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experiments addressing the temporal constraints of transcription factor action in proliferating neural progenitor cells adds to the idea that defined temporal windows, during which transcription factors act to control distinct downstream target genes, are of key importance to neuronal fate acquisition. During Drosophila neuroblast generation, the transcription factor Hunchback controls specification and differentiation of early-born neuroblasts [38]. Over time, however, neuroblasts progressively lose their competence to generate cells of an early fate in response to Hunchback expression [39]. These findings thus also argue for a change in cellular competence to respond to a specific transcription factor over time albeit in an early precursor context. More generally, during the differentiation of hematopoietic lineages, several transcription factors have also been shown to exhibit distinct functions at progressive steps of lineage specification [40]. Analysis of the mechanisms by which transcription factor programs can be shifted over time to control different complements of downstream genes and thus different aspects of neuronal and cellular fates in progenitor cells or post-mitotic neurons may provide further insight into the way in which transcription factors act to control the assembly of neuronal circuits."}

    craft-ca-core-ex-dev

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    2_test

    {"project":"2_test","denotations":[{"id":"15836427-11525736-84719661","span":{"begin":457,"end":459},"obj":"11525736"},{"id":"15836427-14534589-84719662","span":{"begin":602,"end":604},"obj":"14534589"},{"id":"15836427-11262875-84719663","span":{"begin":966,"end":968},"obj":"11262875"},{"id":"T71973","span":{"begin":457,"end":459},"obj":"11525736"},{"id":"T3379","span":{"begin":602,"end":604},"obj":"14534589"},{"id":"T7415","span":{"begin":966,"end":968},"obj":"11262875"}],"text":"Recent experiments addressing the temporal constraints of transcription factor action in proliferating neural progenitor cells adds to the idea that defined temporal windows, during which transcription factors act to control distinct downstream target genes, are of key importance to neuronal fate acquisition. During Drosophila neuroblast generation, the transcription factor Hunchback controls specification and differentiation of early-born neuroblasts [38]. Over time, however, neuroblasts progressively lose their competence to generate cells of an early fate in response to Hunchback expression [39]. These findings thus also argue for a change in cellular competence to respond to a specific transcription factor over time albeit in an early precursor context. More generally, during the differentiation of hematopoietic lineages, several transcription factors have also been shown to exhibit distinct functions at progressive steps of lineage specification [40]. Analysis of the mechanisms by which transcription factor programs can be shifted over time to control different complements of downstream genes and thus different aspects of neuronal and cellular fates in progenitor cells or post-mitotic neurons may provide further insight into the way in which transcription factors act to control the assembly of neuronal circuits."}

    biosemtest

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experiments addressing the temporal constraints of transcription factor action in proliferating neural progenitor cells adds to the idea that defined temporal windows, during which transcription factors act to control distinct downstream target genes, are of key importance to neuronal fate acquisition. During Drosophila neuroblast generation, the transcription factor Hunchback controls specification and differentiation of early-born neuroblasts [38]. Over time, however, neuroblasts progressively lose their competence to generate cells of an early fate in response to Hunchback expression [39]. These findings thus also argue for a change in cellular competence to respond to a specific transcription factor over time albeit in an early precursor context. More generally, during the differentiation of hematopoietic lineages, several transcription factors have also been shown to exhibit distinct functions at progressive steps of lineage specification [40]. Analysis of the mechanisms by which transcription factor programs can be shifted over time to control different complements of downstream genes and thus different aspects of neuronal and cellular fates in progenitor cells or post-mitotic neurons may provide further insight into the way in which transcription factors act to control the assembly of neuronal circuits."}

    craft-ca-core-dev

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