Id |
Subject |
Object |
Predicate |
Lexical cue |
T11307 |
0-3 |
PRP$ |
denotes |
Our |
T11308 |
4-12 |
NNS |
denotes |
findings |
T11309 |
13-16 |
VBP |
denotes |
are |
T11310 |
17-27 |
JJ |
denotes |
compatible |
T11311 |
28-32 |
IN |
denotes |
with |
T11312 |
33-34 |
DT |
denotes |
a |
T11313 |
35-40 |
NN |
denotes |
model |
T11314 |
41-43 |
IN |
denotes |
in |
T11315 |
62-69 |
VBP |
denotes |
acquire |
T11316 |
44-49 |
WDT |
denotes |
which |
T11317 |
50-53 |
NN |
denotes |
DRG |
T11318 |
54-61 |
NNS |
denotes |
neurons |
T11319 |
70-75 |
PRP$ |
denotes |
their |
T11320 |
83-87 |
NN |
denotes |
fate |
T11321 |
76-82 |
JJ |
denotes |
mature |
T11322 |
88-90 |
IN |
denotes |
by |
T11323 |
91-101 |
JJ |
denotes |
sequential |
T11324 |
128-136 |
NN |
denotes |
addition |
T11325 |
102-105 |
CC |
denotes |
and |
T11326 |
106-116 |
RB |
denotes |
temporally |
T11327 |
117-127 |
VBN |
denotes |
controlled |
T11328 |
137-139 |
IN |
denotes |
of |
T11329 |
140-147 |
NN |
denotes |
lineage |
T11330 |
148-156 |
JJ |
denotes |
specific |
T11331 |
147-148 |
HYPH |
denotes |
- |
T11332 |
157-165 |
NNS |
denotes |
features |
T11333 |
166-167 |
-LRB- |
denotes |
( |
T11334 |
167-173 |
NN |
denotes |
Figure |
T11335 |
174-175 |
CD |
denotes |
9 |
T11336 |
175-176 |
-RRB- |
denotes |
) |
T11337 |
176-177 |
. |
denotes |
. |
T11338 |
177-353 |
sentence |
denotes |
Target-derived factors act on predetermined neuronal lineages to switch their developmental programs to become compatible with processes such as target invasion and branching. |
T11339 |
178-184 |
NN |
denotes |
Target |
T11340 |
185-192 |
VBN |
denotes |
derived |
T11341 |
184-185 |
HYPH |
denotes |
- |
T11342 |
193-200 |
NNS |
denotes |
factors |
T11343 |
201-204 |
VBP |
denotes |
act |
T11344 |
205-207 |
IN |
denotes |
on |
T11345 |
208-221 |
VBN |
denotes |
predetermined |
T11346 |
231-239 |
NNS |
denotes |
lineages |
T11347 |
222-230 |
JJ |
denotes |
neuronal |
T11348 |
240-242 |
TO |
denotes |
to |
T11349 |
243-249 |
VB |
denotes |
switch |
T11350 |
250-255 |
PRP$ |
denotes |
their |
T11351 |
270-278 |
NNS |
denotes |
programs |
T11352 |
256-269 |
JJ |
denotes |
developmental |
T11353 |
279-281 |
TO |
denotes |
to |
T11354 |
282-288 |
VB |
denotes |
become |
T11355 |
289-299 |
JJ |
denotes |
compatible |
T11356 |
300-304 |
IN |
denotes |
with |
T11357 |
305-314 |
NNS |
denotes |
processes |
T11358 |
315-319 |
JJ |
denotes |
such |
T11359 |
320-322 |
IN |
denotes |
as |
T11360 |
323-329 |
NN |
denotes |
target |
T11361 |
330-338 |
NN |
denotes |
invasion |
T11362 |
339-342 |
CC |
denotes |
and |
T11363 |
343-352 |
NN |
denotes |
branching |
T11364 |
352-353 |
. |
denotes |
. |
T11365 |
353-559 |
sentence |
denotes |
Such a transition state in the acquisition of a defined neuronal fate would be accompanied by the induction of appropriate transcriptional programs through the expression of specific transcription factors. |
T11366 |
354-358 |
PDT |
denotes |
Such |
T11367 |
372-377 |
NN |
denotes |
state |
T11368 |
359-360 |
DT |
denotes |
a |
T11369 |
361-371 |
NN |
denotes |
transition |
T11370 |
433-444 |
VBN |
denotes |
accompanied |
T11371 |
378-380 |
IN |
denotes |
in |
T11372 |
381-384 |
DT |
denotes |
the |
T11373 |
385-396 |
NN |
denotes |
acquisition |
T11374 |
397-399 |
IN |
denotes |
of |
T11375 |
400-401 |
DT |
denotes |
a |
T11376 |
419-423 |
NN |
denotes |
fate |
T11377 |
402-409 |
VBN |
denotes |
defined |
T11378 |
410-418 |
JJ |
denotes |
neuronal |
T11379 |
424-429 |
MD |
denotes |
would |
T11380 |
430-432 |
VB |
denotes |
be |
T11381 |
445-447 |
IN |
denotes |
by |
T11382 |
448-451 |
DT |
denotes |
the |
T11383 |
452-461 |
NN |
denotes |
induction |
T11384 |
462-464 |
IN |
denotes |
of |
T11385 |
465-476 |
JJ |
denotes |
appropriate |
T11386 |
493-501 |
NNS |
denotes |
programs |
T11387 |
477-492 |
JJ |
denotes |
transcriptional |
T11388 |
502-509 |
IN |
denotes |
through |
T11389 |
510-513 |
DT |
denotes |
the |
T11390 |
514-524 |
NN |
denotes |
expression |
T11391 |
525-527 |
IN |
denotes |
of |
T11392 |
528-536 |
JJ |
denotes |
specific |
T11393 |
551-558 |
NNS |
denotes |
factors |
T11394 |
537-550 |
NN |
denotes |
transcription |
T11395 |
558-559 |
. |
denotes |
. |
T11396 |
559-963 |
sentence |
denotes |
Mechanisms such as chromosomal remodeling that restrict or expand access to certain target genes [34] or activation by cofactors responsible for changing the action of particular transcription factors [35] could represent possible mechanisms by which the downstream transcriptional profile of a transcription factor could be temporally shifted towards the selection and control of distinct target genes. |
T11397 |
560-570 |
NNS |
denotes |
Mechanisms |
T11398 |
772-781 |
VB |
denotes |
represent |
T11399 |
571-575 |
JJ |
denotes |
such |
T11400 |
576-578 |
IN |
denotes |
as |
T11401 |
579-590 |
JJ |
denotes |
chromosomal |
T11402 |
591-601 |
NN |
denotes |
remodeling |
T11403 |
602-606 |
WDT |
denotes |
that |
T11404 |
607-615 |
VB |
denotes |
restrict |
T11405 |
616-618 |
CC |
denotes |
or |
T11406 |
619-625 |
VB |
denotes |
expand |
T11407 |
626-632 |
NN |
denotes |
access |
T11408 |
633-635 |
IN |
denotes |
to |
T11409 |
636-643 |
JJ |
denotes |
certain |
T11410 |
651-656 |
NNS |
denotes |
genes |
T11411 |
644-650 |
NN |
denotes |
target |
T11412 |
657-658 |
-LRB- |
denotes |
[ |
T11413 |
658-660 |
CD |
denotes |
34 |
T11414 |
660-661 |
-RRB- |
denotes |
] |
T11415 |
662-664 |
CC |
denotes |
or |
T11416 |
665-675 |
NN |
denotes |
activation |
T11417 |
676-678 |
IN |
denotes |
by |
T11418 |
679-688 |
NNS |
denotes |
cofactors |
T11419 |
689-700 |
JJ |
denotes |
responsible |
T11420 |
701-704 |
IN |
denotes |
for |
T11421 |
705-713 |
VBG |
denotes |
changing |
T11422 |
714-717 |
DT |
denotes |
the |
T11423 |
718-724 |
NN |
denotes |
action |
T11424 |
725-727 |
IN |
denotes |
of |
T11425 |
728-738 |
JJ |
denotes |
particular |
T11426 |
753-760 |
NNS |
denotes |
factors |
T11427 |
739-752 |
NN |
denotes |
transcription |
T11428 |
761-762 |
-LRB- |
denotes |
[ |
T11429 |
762-764 |
CD |
denotes |
35 |
T11430 |
764-765 |
-RRB- |
denotes |
] |
T11431 |
766-771 |
MD |
denotes |
could |
T11432 |
782-790 |
JJ |
denotes |
possible |
T11433 |
791-801 |
NNS |
denotes |
mechanisms |
T11434 |
802-804 |
IN |
denotes |
by |
T11435 |
896-903 |
VBN |
denotes |
shifted |
T11436 |
805-810 |
WDT |
denotes |
which |
T11437 |
811-814 |
DT |
denotes |
the |
T11438 |
842-849 |
NN |
denotes |
profile |
T11439 |
815-825 |
JJ |
denotes |
downstream |
T11440 |
826-841 |
JJ |
denotes |
transcriptional |
T11441 |
850-852 |
IN |
denotes |
of |
T11442 |
853-854 |
DT |
denotes |
a |
T11443 |
869-875 |
NN |
denotes |
factor |
T11444 |
855-868 |
NN |
denotes |
transcription |
T11445 |
876-881 |
MD |
denotes |
could |
T11446 |
882-884 |
VB |
denotes |
be |
T11447 |
885-895 |
RB |
denotes |
temporally |
T11448 |
904-911 |
IN |
denotes |
towards |
T11449 |
912-915 |
DT |
denotes |
the |
T11450 |
916-925 |
NN |
denotes |
selection |
T11451 |
926-929 |
CC |
denotes |
and |
T11452 |
930-937 |
NN |
denotes |
control |
T11453 |
938-940 |
IN |
denotes |
of |
T11454 |
941-949 |
JJ |
denotes |
distinct |
T11455 |
957-962 |
NNS |
denotes |
genes |
T11456 |
950-956 |
NN |
denotes |
target |
T11457 |
962-963 |
. |
denotes |
. |
T11458 |
963-1147 |
sentence |
denotes |
Interestingly, several ETS transcription factors are activated through release of autoinhibition via interaction with cofactors and/or via post-translational modifications [35,36,37]. |
T11459 |
964-977 |
RB |
denotes |
Interestingly |
T11460 |
1017-1026 |
VBN |
denotes |
activated |
T11461 |
977-979 |
, |
denotes |
, |
T11462 |
979-986 |
JJ |
denotes |
several |
T11463 |
1005-1012 |
NNS |
denotes |
factors |
T11464 |
987-990 |
NN |
denotes |
ETS |
T11465 |
991-1004 |
NN |
denotes |
transcription |
T11466 |
1013-1016 |
VBP |
denotes |
are |
T11467 |
1027-1034 |
IN |
denotes |
through |
T11468 |
1035-1042 |
NN |
denotes |
release |
T11469 |
1043-1045 |
IN |
denotes |
of |
T11470 |
1046-1060 |
NN |
denotes |
autoinhibition |
T11471 |
1061-1064 |
IN |
denotes |
via |
T11472 |
1065-1076 |
NN |
denotes |
interaction |
T11473 |
1077-1081 |
IN |
denotes |
with |
T11474 |
1082-1091 |
NNS |
denotes |
cofactors |
T11475 |
1092-1095 |
CC |
denotes |
and |
T11476 |
1095-1096 |
HYPH |
denotes |
/ |
T11477 |
1096-1098 |
CC |
denotes |
or |
T11478 |
1099-1102 |
IN |
denotes |
via |
T11479 |
1103-1121 |
JJ |
denotes |
post-translational |
T11480 |
1122-1135 |
NNS |
denotes |
modifications |
T11481 |
1136-1137 |
-LRB- |
denotes |
[ |
T11482 |
1143-1145 |
CD |
denotes |
37 |
T11483 |
1137-1139 |
CD |
denotes |
35 |
T11484 |
1139-1140 |
, |
denotes |
, |
T11485 |
1140-1142 |
CD |
denotes |
36 |
T11486 |
1142-1143 |
, |
denotes |
, |
T11487 |
1145-1146 |
-RRB- |
denotes |
] |
T11488 |
1146-1147 |
. |
denotes |
. |
T11489 |
1147-1392 |
sentence |
denotes |
The fusion of EWS with Pea3 could circumvent a need for activation through specific cofactors while still maintaining ETS site dependence, thus rendering EWS-Pea3 less sensitive to the cellular context than endogenous ETS transcription factors. |
T11490 |
1148-1151 |
DT |
denotes |
The |
T11491 |
1152-1158 |
NN |
denotes |
fusion |
T11492 |
1182-1192 |
VB |
denotes |
circumvent |
T11493 |
1159-1161 |
IN |
denotes |
of |
T11494 |
1162-1165 |
NN |
denotes |
EWS |
T11495 |
1166-1170 |
IN |
denotes |
with |
T11496 |
1171-1175 |
NN |
denotes |
Pea3 |
T11497 |
1176-1181 |
MD |
denotes |
could |
T11498 |
1193-1194 |
DT |
denotes |
a |
T11499 |
1195-1199 |
NN |
denotes |
need |
T11500 |
1200-1203 |
IN |
denotes |
for |
T11501 |
1204-1214 |
NN |
denotes |
activation |
T11502 |
1215-1222 |
IN |
denotes |
through |
T11503 |
1223-1231 |
JJ |
denotes |
specific |
T11504 |
1232-1241 |
NNS |
denotes |
cofactors |
T11505 |
1242-1247 |
IN |
denotes |
while |
T11506 |
1254-1265 |
VBG |
denotes |
maintaining |
T11507 |
1248-1253 |
RB |
denotes |
still |
T11508 |
1266-1269 |
NN |
denotes |
ETS |
T11509 |
1275-1285 |
NN |
denotes |
dependence |
T11510 |
1270-1274 |
NN |
denotes |
site |
T11511 |
1285-1287 |
, |
denotes |
, |
T11512 |
1287-1291 |
RB |
denotes |
thus |
T11513 |
1292-1301 |
VBG |
denotes |
rendering |
T11514 |
1302-1305 |
NN |
denotes |
EWS |
T11515 |
1306-1310 |
NN |
denotes |
Pea3 |
T11516 |
1305-1306 |
HYPH |
denotes |
- |
T11517 |
1311-1315 |
RBR |
denotes |
less |
T11518 |
1316-1325 |
JJ |
denotes |
sensitive |
T11519 |
1326-1328 |
IN |
denotes |
to |
T11520 |
1329-1332 |
DT |
denotes |
the |
T11521 |
1342-1349 |
NN |
denotes |
context |
T11522 |
1333-1341 |
JJ |
denotes |
cellular |
T11523 |
1350-1354 |
IN |
denotes |
than |
T11524 |
1355-1365 |
JJ |
denotes |
endogenous |
T11525 |
1384-1391 |
NNS |
denotes |
factors |
T11526 |
1366-1369 |
NN |
denotes |
ETS |
T11527 |
1370-1383 |
NN |
denotes |
transcription |
T11528 |
1391-1392 |
. |
denotes |
. |
T11529 |
1392-1582 |
sentence |
denotes |
Using this fusion protein, our experiments demonstrate a profound change in the action of ETS signaling at the level of transcriptional regulation within post-mitotic DRG neurons over time. |
T11530 |
1393-1398 |
VBG |
denotes |
Using |
T11531 |
1436-1447 |
VBP |
denotes |
demonstrate |
T11532 |
1399-1403 |
DT |
denotes |
this |
T11533 |
1411-1418 |
NN |
denotes |
protein |
T11534 |
1404-1410 |
NN |
denotes |
fusion |
T11535 |
1418-1420 |
, |
denotes |
, |
T11536 |
1420-1423 |
PRP$ |
denotes |
our |
T11537 |
1424-1435 |
NNS |
denotes |
experiments |
T11538 |
1448-1449 |
DT |
denotes |
a |
T11539 |
1459-1465 |
NN |
denotes |
change |
T11540 |
1450-1458 |
JJ |
denotes |
profound |
T11541 |
1466-1468 |
IN |
denotes |
in |
T11542 |
1469-1472 |
DT |
denotes |
the |
T11543 |
1473-1479 |
NN |
denotes |
action |
T11544 |
1480-1482 |
IN |
denotes |
of |
T11545 |
1483-1486 |
NN |
denotes |
ETS |
T11546 |
1487-1496 |
NN |
denotes |
signaling |
T11547 |
1497-1499 |
IN |
denotes |
at |
T11548 |
1500-1503 |
DT |
denotes |
the |
T11549 |
1504-1509 |
NN |
denotes |
level |
T11550 |
1510-1512 |
IN |
denotes |
of |
T11551 |
1513-1528 |
JJ |
denotes |
transcriptional |
T11552 |
1529-1539 |
NN |
denotes |
regulation |
T11553 |
1540-1546 |
IN |
denotes |
within |
T11554 |
1547-1559 |
JJ |
denotes |
post-mitotic |
T11555 |
1564-1571 |
NNS |
denotes |
neurons |
T11556 |
1560-1563 |
NN |
denotes |
DRG |
T11557 |
1572-1576 |
IN |
denotes |
over |
T11558 |
1577-1581 |
NN |
denotes |
time |
T11559 |
1581-1582 |
. |
denotes |
. |
T11560 |
1582-1791 |
sentence |
denotes |
Moreover, the observed transcriptional shift in ETS signaling is paired with the onset of appropriate regulation of neuronal subtype specification and establishment of axonal projections into the target area. |
T11561 |
1583-1591 |
RB |
denotes |
Moreover |
T11562 |
1648-1654 |
VBN |
denotes |
paired |
T11563 |
1591-1593 |
, |
denotes |
, |
T11564 |
1593-1596 |
DT |
denotes |
the |
T11565 |
1622-1627 |
NN |
denotes |
shift |
T11566 |
1597-1605 |
VBN |
denotes |
observed |
T11567 |
1606-1621 |
JJ |
denotes |
transcriptional |
T11568 |
1628-1630 |
IN |
denotes |
in |
T11569 |
1631-1634 |
NN |
denotes |
ETS |
T11570 |
1635-1644 |
NN |
denotes |
signaling |
T11571 |
1645-1647 |
VBZ |
denotes |
is |
T11572 |
1655-1659 |
IN |
denotes |
with |
T11573 |
1660-1663 |
DT |
denotes |
the |
T11574 |
1664-1669 |
NN |
denotes |
onset |
T11575 |
1670-1672 |
IN |
denotes |
of |
T11576 |
1673-1684 |
JJ |
denotes |
appropriate |
T11577 |
1685-1695 |
NN |
denotes |
regulation |
T11578 |
1696-1698 |
IN |
denotes |
of |
T11579 |
1699-1707 |
JJ |
denotes |
neuronal |
T11580 |
1716-1729 |
NN |
denotes |
specification |
T11581 |
1708-1715 |
NN |
denotes |
subtype |
T11582 |
1730-1733 |
CC |
denotes |
and |
T11583 |
1734-1747 |
NN |
denotes |
establishment |
T11584 |
1748-1750 |
IN |
denotes |
of |
T11585 |
1751-1757 |
JJ |
denotes |
axonal |
T11586 |
1758-1769 |
NNS |
denotes |
projections |
T11587 |
1770-1774 |
IN |
denotes |
into |
T11588 |
1775-1778 |
DT |
denotes |
the |
T11589 |
1786-1790 |
NN |
denotes |
area |
T11590 |
1779-1785 |
NN |
denotes |
target |
T11591 |
1790-1791 |
. |
denotes |
. |
R4788 |
T11307 |
T11308 |
poss |
Our,findings |
R4789 |
T11308 |
T11309 |
nsubj |
findings,are |
R4790 |
T11310 |
T11309 |
acomp |
compatible,are |
R4791 |
T11311 |
T11310 |
prep |
with,compatible |
R4792 |
T11312 |
T11313 |
det |
a,model |
R4793 |
T11313 |
T11311 |
pobj |
model,with |
R4794 |
T11314 |
T11315 |
prep |
in,acquire |
R4795 |
T11315 |
T11313 |
relcl |
acquire,model |
R4796 |
T11316 |
T11314 |
pobj |
which,in |
R4797 |
T11317 |
T11318 |
compound |
DRG,neurons |
R4798 |
T11318 |
T11315 |
nsubj |
neurons,acquire |
R4799 |
T11319 |
T11320 |
poss |
their,fate |
R4800 |
T11320 |
T11315 |
dobj |
fate,acquire |
R4801 |
T11321 |
T11320 |
amod |
mature,fate |
R4802 |
T11322 |
T11315 |
prep |
by,acquire |
R4803 |
T11323 |
T11324 |
amod |
sequential,addition |
R4804 |
T11324 |
T11322 |
pobj |
addition,by |
R4805 |
T11325 |
T11323 |
cc |
and,sequential |
R4806 |
T11326 |
T11327 |
advmod |
temporally,controlled |
R4807 |
T11327 |
T11323 |
conj |
controlled,sequential |
R4808 |
T11328 |
T11324 |
prep |
of,addition |
R4809 |
T11329 |
T11330 |
npadvmod |
lineage,specific |
R4810 |
T11330 |
T11332 |
amod |
specific,features |
R4811 |
T11331 |
T11330 |
punct |
-,specific |
R4812 |
T11332 |
T11328 |
pobj |
features,of |
R4813 |
T11333 |
T11334 |
punct |
(,Figure |
R4814 |
T11334 |
T11315 |
parataxis |
Figure,acquire |
R4815 |
T11335 |
T11334 |
nummod |
9,Figure |
R4816 |
T11336 |
T11334 |
punct |
),Figure |
R4817 |
T11337 |
T11309 |
punct |
.,are |
R4818 |
T11339 |
T11340 |
npadvmod |
Target,derived |
R4819 |
T11340 |
T11342 |
amod |
derived,factors |
R4820 |
T11341 |
T11340 |
punct |
-,derived |
R4821 |
T11342 |
T11343 |
nsubj |
factors,act |
R4822 |
T11344 |
T11343 |
prep |
on,act |
R4823 |
T11345 |
T11346 |
amod |
predetermined,lineages |
R4824 |
T11346 |
T11344 |
pobj |
lineages,on |
R4825 |
T11347 |
T11346 |
amod |
neuronal,lineages |
R4826 |
T11348 |
T11349 |
aux |
to,switch |
R4827 |
T11349 |
T11343 |
advcl |
switch,act |
R4828 |
T11350 |
T11351 |
poss |
their,programs |
R4829 |
T11351 |
T11349 |
dobj |
programs,switch |
R4830 |
T11352 |
T11351 |
amod |
developmental,programs |
R4831 |
T11353 |
T11354 |
aux |
to,become |
R4832 |
T11354 |
T11349 |
advcl |
become,switch |
R4833 |
T11355 |
T11354 |
acomp |
compatible,become |
R4834 |
T11356 |
T11355 |
prep |
with,compatible |
R4835 |
T11357 |
T11356 |
pobj |
processes,with |
R4836 |
T11358 |
T11359 |
amod |
such,as |
R4837 |
T11359 |
T11357 |
prep |
as,processes |
R4838 |
T11360 |
T11361 |
compound |
target,invasion |
R4839 |
T11361 |
T11359 |
pobj |
invasion,as |
R4840 |
T11362 |
T11361 |
cc |
and,invasion |
R4841 |
T11363 |
T11361 |
conj |
branching,invasion |
R4842 |
T11364 |
T11343 |
punct |
.,act |
R4843 |
T11366 |
T11367 |
predet |
Such,state |
R4844 |
T11367 |
T11370 |
nsubjpass |
state,accompanied |
R4845 |
T11368 |
T11367 |
det |
a,state |
R4846 |
T11369 |
T11367 |
compound |
transition,state |
R4847 |
T11371 |
T11367 |
prep |
in,state |
R4848 |
T11372 |
T11373 |
det |
the,acquisition |
R4849 |
T11373 |
T11371 |
pobj |
acquisition,in |
R4850 |
T11374 |
T11373 |
prep |
of,acquisition |
R4851 |
T11375 |
T11376 |
det |
a,fate |
R4852 |
T11376 |
T11374 |
pobj |
fate,of |
R4853 |
T11377 |
T11376 |
amod |
defined,fate |
R4854 |
T11378 |
T11376 |
amod |
neuronal,fate |
R4855 |
T11379 |
T11370 |
aux |
would,accompanied |
R4856 |
T11380 |
T11370 |
auxpass |
be,accompanied |
R4857 |
T11381 |
T11370 |
agent |
by,accompanied |
R4858 |
T11382 |
T11383 |
det |
the,induction |
R4859 |
T11383 |
T11381 |
pobj |
induction,by |
R4860 |
T11384 |
T11383 |
prep |
of,induction |
R4861 |
T11385 |
T11386 |
amod |
appropriate,programs |
R4862 |
T11386 |
T11384 |
pobj |
programs,of |
R4863 |
T11387 |
T11386 |
amod |
transcriptional,programs |
R4864 |
T11388 |
T11383 |
prep |
through,induction |
R4865 |
T11389 |
T11390 |
det |
the,expression |
R4866 |
T11390 |
T11388 |
pobj |
expression,through |
R4867 |
T11391 |
T11390 |
prep |
of,expression |
R4868 |
T11392 |
T11393 |
amod |
specific,factors |
R4869 |
T11393 |
T11391 |
pobj |
factors,of |
R4870 |
T11394 |
T11393 |
compound |
transcription,factors |
R4871 |
T11395 |
T11370 |
punct |
.,accompanied |
R4872 |
T11397 |
T11398 |
nsubj |
Mechanisms,represent |
R4873 |
T11399 |
T11400 |
amod |
such,as |
R4874 |
T11400 |
T11397 |
prep |
as,Mechanisms |
R4875 |
T11401 |
T11402 |
amod |
chromosomal,remodeling |
R4876 |
T11402 |
T11400 |
pobj |
remodeling,as |
R4877 |
T11403 |
T11404 |
dep |
that,restrict |
R4878 |
T11404 |
T11397 |
relcl |
restrict,Mechanisms |
R4879 |
T11405 |
T11404 |
cc |
or,restrict |
R4880 |
T11406 |
T11404 |
conj |
expand,restrict |
R4881 |
T11407 |
T11406 |
dobj |
access,expand |
R4882 |
T11408 |
T11407 |
prep |
to,access |
R4883 |
T11409 |
T11410 |
amod |
certain,genes |
R4884 |
T11410 |
T11408 |
pobj |
genes,to |
R4885 |
T11411 |
T11410 |
compound |
target,genes |
R4886 |
T11412 |
T11413 |
punct |
[,34 |
R4887 |
T11413 |
T11407 |
parataxis |
34,access |
R4888 |
T11414 |
T11413 |
punct |
],34 |
R4889 |
T11415 |
T11407 |
cc |
or,access |
R4890 |
T11416 |
T11407 |
conj |
activation,access |
R4891 |
T11417 |
T11416 |
prep |
by,activation |
R4892 |
T11418 |
T11417 |
pobj |
cofactors,by |
R4893 |
T11419 |
T11418 |
amod |
responsible,cofactors |
R4894 |
T11420 |
T11419 |
prep |
for,responsible |
R4895 |
T11421 |
T11420 |
pcomp |
changing,for |
R4896 |
T11422 |
T11423 |
det |
the,action |
R4897 |
T11423 |
T11421 |
dobj |
action,changing |
R4898 |
T11424 |
T11423 |
prep |
of,action |
R4899 |
T11425 |
T11426 |
amod |
particular,factors |
R4900 |
T11426 |
T11424 |
pobj |
factors,of |
R4901 |
T11427 |
T11426 |
compound |
transcription,factors |
R4902 |
T11428 |
T11429 |
punct |
[,35 |
R4903 |
T11429 |
T11406 |
parataxis |
35,expand |
R4904 |
T11430 |
T11429 |
punct |
],35 |
R4905 |
T11431 |
T11398 |
aux |
could,represent |
R4906 |
T11432 |
T11433 |
amod |
possible,mechanisms |
R4907 |
T11433 |
T11398 |
dobj |
mechanisms,represent |
R4908 |
T11434 |
T11435 |
prep |
by,shifted |
R4909 |
T11435 |
T11398 |
ccomp |
shifted,represent |
R4910 |
T11436 |
T11434 |
pobj |
which,by |
R4911 |
T11437 |
T11438 |
det |
the,profile |
R4912 |
T11438 |
T11435 |
nsubjpass |
profile,shifted |
R4913 |
T11439 |
T11438 |
amod |
downstream,profile |
R4914 |
T11440 |
T11438 |
amod |
transcriptional,profile |
R4915 |
T11441 |
T11438 |
prep |
of,profile |
R4916 |
T11442 |
T11443 |
det |
a,factor |
R4917 |
T11443 |
T11441 |
pobj |
factor,of |
R4918 |
T11444 |
T11443 |
compound |
transcription,factor |
R4919 |
T11445 |
T11435 |
aux |
could,shifted |
R4920 |
T11446 |
T11435 |
auxpass |
be,shifted |
R4921 |
T11447 |
T11435 |
advmod |
temporally,shifted |
R4922 |
T11448 |
T11435 |
prep |
towards,shifted |
R4923 |
T11449 |
T11450 |
det |
the,selection |
R4924 |
T11450 |
T11448 |
pobj |
selection,towards |
R4925 |
T11451 |
T11450 |
cc |
and,selection |
R4926 |
T11452 |
T11450 |
conj |
control,selection |
R4927 |
T11453 |
T11450 |
prep |
of,selection |
R4928 |
T11454 |
T11455 |
amod |
distinct,genes |
R4929 |
T11455 |
T11453 |
pobj |
genes,of |
R4930 |
T11456 |
T11455 |
compound |
target,genes |
R4931 |
T11457 |
T11398 |
punct |
.,represent |
R4932 |
T11459 |
T11460 |
advmod |
Interestingly,activated |
R4933 |
T11461 |
T11460 |
punct |
", ",activated |
R4934 |
T11462 |
T11463 |
amod |
several,factors |
R4935 |
T11463 |
T11460 |
nsubjpass |
factors,activated |
R4936 |
T11464 |
T11463 |
compound |
ETS,factors |
R4937 |
T11465 |
T11463 |
compound |
transcription,factors |
R4938 |
T11466 |
T11460 |
auxpass |
are,activated |
R4939 |
T11467 |
T11460 |
prep |
through,activated |
R4940 |
T11468 |
T11467 |
pobj |
release,through |
R4941 |
T11469 |
T11468 |
prep |
of,release |
R4942 |
T11470 |
T11469 |
pobj |
autoinhibition,of |
R4943 |
T11471 |
T11460 |
prep |
via,activated |
R4944 |
T11472 |
T11471 |
pobj |
interaction,via |
R4945 |
T11473 |
T11472 |
prep |
with,interaction |
R4946 |
T11474 |
T11473 |
pobj |
cofactors,with |
R4947 |
T11475 |
T11471 |
cc |
and,via |
R4948 |
T11476 |
T11475 |
punct |
/,and |
R4949 |
T11477 |
T11475 |
cc |
or,and |
R4950 |
T11478 |
T11471 |
conj |
via,via |
R4951 |
T11479 |
T11480 |
amod |
post-translational,modifications |
R4952 |
T11480 |
T11478 |
pobj |
modifications,via |
R4953 |
T11481 |
T11482 |
punct |
[,37 |
R4954 |
T11482 |
T11460 |
parataxis |
37,activated |
R4955 |
T11483 |
T11482 |
nummod |
35,37 |
R4956 |
T11484 |
T11482 |
punct |
",",37 |
R4957 |
T11485 |
T11482 |
nummod |
36,37 |
R4958 |
T11486 |
T11482 |
punct |
",",37 |
R4959 |
T11487 |
T11482 |
punct |
],37 |
R4960 |
T11488 |
T11460 |
punct |
.,activated |
R4961 |
T11490 |
T11491 |
det |
The,fusion |
R4962 |
T11491 |
T11492 |
nsubj |
fusion,circumvent |
R4963 |
T11493 |
T11491 |
prep |
of,fusion |
R4964 |
T11494 |
T11493 |
pobj |
EWS,of |
R4965 |
T11495 |
T11491 |
prep |
with,fusion |
R4966 |
T11496 |
T11495 |
pobj |
Pea3,with |
R4967 |
T11497 |
T11492 |
aux |
could,circumvent |
R4968 |
T11498 |
T11499 |
det |
a,need |
R4969 |
T11499 |
T11492 |
dobj |
need,circumvent |
R4970 |
T11500 |
T11499 |
prep |
for,need |
R4971 |
T11501 |
T11500 |
pobj |
activation,for |
R4972 |
T11502 |
T11492 |
prep |
through,circumvent |
R4973 |
T11503 |
T11504 |
amod |
specific,cofactors |
R4974 |
T11504 |
T11502 |
pobj |
cofactors,through |
R4975 |
T11505 |
T11506 |
mark |
while,maintaining |
R4976 |
T11506 |
T11492 |
advcl |
maintaining,circumvent |
R4977 |
T11507 |
T11506 |
advmod |
still,maintaining |
R4978 |
T11508 |
T11509 |
compound |
ETS,dependence |
R4979 |
T11509 |
T11506 |
dobj |
dependence,maintaining |
R4980 |
T11510 |
T11509 |
compound |
site,dependence |
R4981 |
T11511 |
T11492 |
punct |
", ",circumvent |
R4982 |
T11512 |
T11513 |
advmod |
thus,rendering |
R4983 |
T11513 |
T11492 |
advcl |
rendering,circumvent |
R4984 |
T11514 |
T11515 |
compound |
EWS,Pea3 |
R4985 |
T11515 |
T11513 |
dobj |
Pea3,rendering |
R4986 |
T11516 |
T11515 |
punct |
-,Pea3 |
R4987 |
T11517 |
T11518 |
advmod |
less,sensitive |
R4988 |
T11518 |
T11513 |
oprd |
sensitive,rendering |
R4989 |
T11519 |
T11518 |
prep |
to,sensitive |
R4990 |
T11520 |
T11521 |
det |
the,context |
R4991 |
T11521 |
T11519 |
pobj |
context,to |
R4992 |
T11522 |
T11521 |
amod |
cellular,context |
R4993 |
T11523 |
T11518 |
prep |
than,sensitive |
R4994 |
T11524 |
T11525 |
amod |
endogenous,factors |
R4995 |
T11525 |
T11523 |
pobj |
factors,than |
R4996 |
T11526 |
T11525 |
compound |
ETS,factors |
R4997 |
T11527 |
T11525 |
compound |
transcription,factors |
R4998 |
T11528 |
T11492 |
punct |
.,circumvent |
R4999 |
T11530 |
T11531 |
advcl |
Using,demonstrate |
R5000 |
T11532 |
T11533 |
det |
this,protein |
R5001 |
T11533 |
T11530 |
dobj |
protein,Using |
R5002 |
T11534 |
T11533 |
compound |
fusion,protein |
R5003 |
T11535 |
T11531 |
punct |
", ",demonstrate |
R5004 |
T11536 |
T11537 |
poss |
our,experiments |
R5005 |
T11537 |
T11531 |
nsubj |
experiments,demonstrate |
R5006 |
T11538 |
T11539 |
det |
a,change |
R5007 |
T11539 |
T11531 |
dobj |
change,demonstrate |
R5008 |
T11540 |
T11539 |
amod |
profound,change |
R5009 |
T11541 |
T11539 |
prep |
in,change |
R5010 |
T11542 |
T11543 |
det |
the,action |
R5011 |
T11543 |
T11541 |
pobj |
action,in |
R5012 |
T11544 |
T11543 |
prep |
of,action |
R5013 |
T11545 |
T11546 |
compound |
ETS,signaling |
R5014 |
T11546 |
T11544 |
pobj |
signaling,of |
R5015 |
T11547 |
T11531 |
prep |
at,demonstrate |
R5016 |
T11548 |
T11549 |
det |
the,level |
R5017 |
T11549 |
T11547 |
pobj |
level,at |
R5018 |
T11550 |
T11549 |
prep |
of,level |
R5019 |
T11551 |
T11552 |
amod |
transcriptional,regulation |
R5020 |
T11552 |
T11550 |
pobj |
regulation,of |
R5021 |
T11553 |
T11549 |
prep |
within,level |
R5022 |
T11554 |
T11555 |
amod |
post-mitotic,neurons |
R5023 |
T11555 |
T11553 |
pobj |
neurons,within |
R5024 |
T11556 |
T11555 |
compound |
DRG,neurons |
R5025 |
T11557 |
T11531 |
prep |
over,demonstrate |
R5026 |
T11558 |
T11557 |
pobj |
time,over |
R5027 |
T11559 |
T11531 |
punct |
.,demonstrate |
R5028 |
T11561 |
T11562 |
advmod |
Moreover,paired |
R5029 |
T11563 |
T11562 |
punct |
", ",paired |
R5030 |
T11564 |
T11565 |
det |
the,shift |
R5031 |
T11565 |
T11562 |
nsubjpass |
shift,paired |
R5032 |
T11566 |
T11565 |
amod |
observed,shift |
R5033 |
T11567 |
T11565 |
amod |
transcriptional,shift |
R5034 |
T11568 |
T11565 |
prep |
in,shift |
R5035 |
T11569 |
T11570 |
compound |
ETS,signaling |
R5036 |
T11570 |
T11568 |
pobj |
signaling,in |
R5037 |
T11571 |
T11562 |
auxpass |
is,paired |
R5038 |
T11572 |
T11562 |
prep |
with,paired |
R5039 |
T11573 |
T11574 |
det |
the,onset |
R5040 |
T11574 |
T11572 |
pobj |
onset,with |
R5041 |
T11575 |
T11574 |
prep |
of,onset |
R5042 |
T11576 |
T11577 |
amod |
appropriate,regulation |
R5043 |
T11577 |
T11575 |
pobj |
regulation,of |
R5044 |
T11578 |
T11577 |
prep |
of,regulation |
R5045 |
T11579 |
T11580 |
amod |
neuronal,specification |
R5046 |
T11580 |
T11578 |
pobj |
specification,of |
R5047 |
T11581 |
T11580 |
compound |
subtype,specification |
R5048 |
T11582 |
T11577 |
cc |
and,regulation |
R5049 |
T11583 |
T11577 |
conj |
establishment,regulation |
R5050 |
T11584 |
T11583 |
prep |
of,establishment |
R5051 |
T11585 |
T11586 |
amod |
axonal,projections |
R5052 |
T11586 |
T11584 |
pobj |
projections,of |
R5053 |
T11587 |
T11586 |
prep |
into,projections |
R5054 |
T11588 |
T11589 |
det |
the,area |
R5055 |
T11589 |
T11587 |
pobj |
area,into |
R5056 |
T11590 |
T11589 |
compound |
target,area |
R5057 |
T11591 |
T11562 |
punct |
.,paired |