PMC:1084331 / 32660-33589 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T10766","span":{"begin":0,"end":6},"obj":"NN"},{"id":"T10767","span":{"begin":7,"end":14},"obj":"VBN"},{"id":"T10768","span":{"begin":6,"end":7},"obj":"HYPH"},{"id":"T10769","span":{"begin":15,"end":22},"obj":"NNS"},{"id":"T10770","span":{"begin":23,"end":30},"obj":"VBP"},{"id":"T10771","span":{"begin":31,"end":32},"obj":"DT"},{"id":"T10772","span":{"begin":43,"end":47},"obj":"NN"},{"id":"T10773","span":{"begin":33,"end":42},"obj":"VBN"},{"id":"T10774","span":{"begin":48,"end":50},"obj":"IN"},{"id":"T10775","span":{"begin":51,"end":54},"obj":"DT"},{"id":"T10776","span":{"begin":55,"end":64},"obj":"NN"},{"id":"T10777","span":{"begin":65,"end":67},"obj":"IN"},{"id":"T10778","span":{"begin":68,"end":75},"obj":"VBN"},{"id":"T10779","span":{"begin":76,"end":84},"obj":"NNS"},{"id":"T10780","span":{"begin":85,"end":87},"obj":"IN"},{"id":"T10781","span":{"begin":88,"end":101},"obj":"NN"},{"id":"T10782","span":{"begin":102,"end":108},"obj":"NN"},{"id":"T10783","span":{"begin":109,"end":119},"obj":"NN"},{"id":"T10784","span":{"begin":120,"end":124},"obj":"JJ"},{"id":"T10785","span":{"begin":125,"end":127},"obj":"IN"},{"id":"T10786","span":{"begin":128,"end":140},"obj":"JJ"},{"id":"T10787","span":{"begin":150,"end":165},"obj":"NN"},{"id":"T10788","span":{"begin":141,"end":149},"obj":"JJ"},{"id":"T10789","span":{"begin":166,"end":167},"obj":"-LRB-"},{"id":"T10790","span":{"begin":167,"end":169},"obj":"CD"},{"id":"T10791","span":{"begin":169,"end":170},"obj":"-RRB-"},{"id":"T10792","span":{"begin":170,"end":171},"obj":"."},{"id":"T10793","span":{"begin":171,"end":342},"obj":"sentence"},{"id":"T10794","span":{"begin":172,"end":176},"obj":"DT"},{"id":"T10795","span":{"begin":177,"end":182},"obj":"NN"},{"id":"T10796","span":{"begin":183,"end":191},"obj":"VBZ"},{"id":"T10797","span":{"begin":192,"end":200},"obj":"NN"},{"id":"T10798","span":{"begin":201,"end":205},"obj":"IN"},{"id":"T10799","span":{"begin":256,"end":258},"obj":"VBZ"},{"id":"T10800","span":{"begin":206,"end":209},"obj":"DT"},{"id":"T10801","span":{"begin":215,"end":220},"obj":"NN"},{"id":"T10802","span":{"begin":210,"end":214},"obj":"JJ"},{"id":"T10803","span":{"begin":221,"end":223},"obj":"IN"},{"id":"T10804","span":{"begin":224,"end":237},"obj":"NN"},{"id":"T10805","span":{"begin":238,"end":244},"obj":"NN"},{"id":"T10806","span":{"begin":245,"end":255},"obj":"NN"},{"id":"T10807","span":{"begin":259,"end":268},"obj":"JJ"},{"id":"T10808","span":{"begin":269,"end":272},"obj":"IN"},{"id":"T10809","span":{"begin":273,"end":277},"obj":"JJ"},{"id":"T10810","span":{"begin":284,"end":291},"obj":"NNS"},{"id":"T10811","span":{"begin":278,"end":283},"obj":"JJ"},{"id":"T10812","span":{"begin":292,"end":294},"obj":"IN"},{"id":"T10813","span":{"begin":295,"end":303},"obj":"JJ"},{"id":"T10814","span":{"begin":304,"end":319},"obj":"NN"},{"id":"T10815","span":{"begin":320,"end":323},"obj":"CC"},{"id":"T10816","span":{"begin":324,"end":331},"obj":"NN"},{"id":"T10817","span":{"begin":332,"end":341},"obj":"NN"},{"id":"T10818","span":{"begin":341,"end":342},"obj":"."},{"id":"T10819","span":{"begin":342,"end":554},"obj":"sentence"},{"id":"T10820","span":{"begin":343,"end":346},"obj":"PRP$"},{"id":"T10821","span":{"begin":347,"end":351},"obj":"NNS"},{"id":"T10822","span":{"begin":352,"end":360},"obj":"VBP"},{"id":"T10823","span":{"begin":361,"end":365},"obj":"IN"},{"id":"T10824","span":{"begin":378,"end":385},"obj":"VBP"},{"id":"T10825","span":{"begin":366,"end":369},"obj":"NN"},{"id":"T10826","span":{"begin":370,"end":377},"obj":"NNS"},{"id":"T10827","span":{"begin":386,"end":387},"obj":"DT"},{"id":"T10828","span":{"begin":397,"end":403},"obj":"NN"},{"id":"T10829","span":{"begin":388,"end":396},"obj":"JJ"},{"id":"T10830","span":{"begin":404,"end":406},"obj":"IN"},{"id":"T10831","span":{"begin":407,"end":412},"obj":"PRP$"},{"id":"T10832","span":{"begin":413,"end":423},"obj":"NN"},{"id":"T10833","span":{"begin":424,"end":426},"obj":"TO"},{"id":"T10834","span":{"begin":427,"end":434},"obj":"VB"},{"id":"T10835","span":{"begin":435,"end":437},"obj":"IN"},{"id":"T10836","span":{"begin":438,"end":441},"obj":"NN"},{"id":"T10837","span":{"begin":463,"end":472},"obj":"NN"},{"id":"T10838","span":{"begin":442,"end":455},"obj":"NN"},{"id":"T10839","span":{"begin":456,"end":462},"obj":"NN"},{"id":"T10840","span":{"begin":472,"end":474},"obj":","},{"id":"T10841","span":{"begin":474,"end":476},"obj":"IN"},{"id":"T10842","span":{"begin":477,"end":485},"obj":"VBN"},{"id":"T10843","span":{"begin":486,"end":488},"obj":"IN"},{"id":"T10844","span":{"begin":489,"end":496},"obj":"NNS"},{"id":"T10845","span":{"begin":497,"end":499},"obj":"IN"},{"id":"T10846","span":{"begin":500,"end":504},"obj":"NN"},{"id":"T10847","span":{"begin":505,"end":515},"obj":"NN"},{"id":"T10848","span":{"begin":516,"end":519},"obj":"CC"},{"id":"T10849","span":{"begin":520,"end":526},"obj":"JJ"},{"id":"T10850","span":{"begin":534,"end":542},"obj":"NN"},{"id":"T10851","span":{"begin":527,"end":533},"obj":"NN"},{"id":"T10852","span":{"begin":543,"end":544},"obj":"-LRB-"},{"id":"T10853","span":{"begin":544,"end":550},"obj":"NN"},{"id":"T10854","span":{"begin":551,"end":552},"obj":"CD"},{"id":"T10855","span":{"begin":552,"end":553},"obj":"-RRB-"},{"id":"T10856","span":{"begin":553,"end":554},"obj":"."},{"id":"T10857","span":{"begin":554,"end":699},"obj":"sentence"},{"id":"T10858","span":{"begin":555,"end":558},"obj":"PRP$"},{"id":"T10859","span":{"begin":559,"end":567},"obj":"NNS"},{"id":"T10860","span":{"begin":568,"end":573},"obj":"VBP"},{"id":"T10861","span":{"begin":574,"end":577},"obj":"IN"},{"id":"T10862","span":{"begin":578,"end":581},"obj":"DT"},{"id":"T10863","span":{"begin":582,"end":591},"obj":"NN"},{"id":"T10864","span":{"begin":592,"end":594},"obj":"IN"},{"id":"T10865","span":{"begin":595,"end":601},"obj":"NN"},{"id":"T10866","span":{"begin":602,"end":609},"obj":"VBN"},{"id":"T10867","span":{"begin":601,"end":602},"obj":"HYPH"},{"id":"T10868","span":{"begin":648,"end":660},"obj":"NN"},{"id":"T10869","span":{"begin":609,"end":611},"obj":","},{"id":"T10870","span":{"begin":611,"end":614},"obj":"CC"},{"id":"T10871","span":{"begin":615,"end":624},"obj":"RB"},{"id":"T10872","span":{"begin":625,"end":635},"obj":"RB"},{"id":"T10873","span":{"begin":636,"end":646},"obj":"VBN"},{"id":"T10874","span":{"begin":646,"end":648},"obj":","},{"id":"T10875","span":{"begin":661,"end":663},"obj":"IN"},{"id":"T10876","span":{"begin":664,"end":667},"obj":"NN"},{"id":"T10877","span":{"begin":689,"end":698},"obj":"NN"},{"id":"T10878","span":{"begin":668,"end":681},"obj":"NN"},{"id":"T10879","span":{"begin":682,"end":688},"obj":"NN"},{"id":"T10880","span":{"begin":698,"end":699},"obj":"."},{"id":"T10881","span":{"begin":699,"end":929},"obj":"sentence"},{"id":"T10882","span":{"begin":700,"end":704},"obj":"RBR"},{"id":"T10883","span":{"begin":705,"end":714},"obj":"RB"},{"id":"T10884","span":{"begin":721,"end":728},"obj":"VBP"},{"id":"T10885","span":{"begin":714,"end":716},"obj":","},{"id":"T10886","span":{"begin":716,"end":720},"obj":"PRP"},{"id":"T10887","span":{"begin":729,"end":733},"obj":"IN"},{"id":"T10888","span":{"begin":872,"end":882},"obj":"VBZ"},{"id":"T10889","span":{"begin":734,"end":744},"obj":"RB"},{"id":"T10890","span":{"begin":745,"end":754},"obj":"VBN"},{"id":"T10891","span":{"begin":755,"end":765},"obj":"NN"},{"id":"T10892","span":{"begin":766,"end":768},"obj":"IN"},{"id":"T10893","span":{"begin":769,"end":784},"obj":"JJ"},{"id":"T10894","span":{"begin":785,"end":793},"obj":"NNS"},{"id":"T10895","span":{"begin":794,"end":801},"obj":"VBN"},{"id":"T10896","span":{"begin":802,"end":804},"obj":"IN"},{"id":"T10897","span":{"begin":805,"end":806},"obj":"DT"},{"id":"T10898","span":{"begin":818,"end":822},"obj":"NN"},{"id":"T10899","span":{"begin":807,"end":817},"obj":"JJ"},{"id":"T10900","span":{"begin":823,"end":830},"obj":"VBN"},{"id":"T10901","span":{"begin":831,"end":833},"obj":"IN"},{"id":"T10902","span":{"begin":834,"end":841},"obj":"NNS"},{"id":"T10903","span":{"begin":842,"end":844},"obj":"IN"},{"id":"T10904","span":{"begin":845,"end":850},"obj":"JJ"},{"id":"T10905","span":{"begin":865,"end":871},"obj":"NNS"},{"id":"T10906","span":{"begin":851,"end":864},"obj":"JJ"},{"id":"T10907","span":{"begin":883,"end":885},"obj":"DT"},{"id":"T10908","span":{"begin":896,"end":905},"obj":"NN"},{"id":"T10909","span":{"begin":886,"end":895},"obj":"JJ"},{"id":"T10910","span":{"begin":906,"end":908},"obj":"IN"},{"id":"T10911","span":{"begin":909,"end":917},"obj":"JJ"},{"id":"T10912","span":{"begin":918,"end":928},"obj":"NN"},{"id":"T10913","span":{"begin":928,"end":929},"obj":"."}],"relations":[{"id":"R4279","pred":"npadvmod","subj":"T10766","obj":"T10767"},{"id":"R4280","pred":"amod","subj":"T10767","obj":"T10769"},{"id":"R4281","pred":"punct","subj":"T10768","obj":"T10767"},{"id":"R4282","pred":"nsubj","subj":"T10769","obj":"T10770"},{"id":"R4283","pred":"det","subj":"T10771","obj":"T10772"},{"id":"R4284","pred":"dobj","subj":"T10772","obj":"T10770"},{"id":"R4285","pred":"amod","subj":"T10773","obj":"T10772"},{"id":"R4286","pred":"prep","subj":"T10774","obj":"T10772"},{"id":"R4287","pred":"det","subj":"T10775","obj":"T10776"},{"id":"R4288","pred":"pobj","subj":"T10776","obj":"T10774"},{"id":"R4289","pred":"prep","subj":"T10777","obj":"T10776"},{"id":"R4290","pred":"amod","subj":"T10778","obj":"T10779"},{"id":"R4291","pred":"pobj","subj":"T10779","obj":"T10777"},{"id":"R4292","pred":"prep","subj":"T10780","obj":"T10779"},{"id":"R4293","pred":"compound","subj":"T10781","obj":"T10782"},{"id":"R4294","pred":"compound","subj":"T10782","obj":"T10783"},{"id":"R4295","pred":"pobj","subj":"T10783","obj":"T10780"},{"id":"R4296","pred":"amod","subj":"T10784","obj":"T10776"},{"id":"R4297","pred":"prep","subj":"T10785","obj":"T10784"},{"id":"R4298","pred":"amod","subj":"T10786","obj":"T10787"},{"id":"R4299","pred":"pobj","subj":"T10787","obj":"T10785"},{"id":"R4300","pred":"amod","subj":"T10788","obj":"T10787"},{"id":"R4301","pred":"punct","subj":"T10789","obj":"T10790"},{"id":"R4302","pred":"parataxis","subj":"T10790","obj":"T10770"},{"id":"R4303","pred":"punct","subj":"T10791","obj":"T10790"},{"id":"R4304","pred":"punct","subj":"T10792","obj":"T10770"},{"id":"R4305","pred":"det","subj":"T10794","obj":"T10795"},{"id":"R4306","pred":"nsubj","subj":"T10795","obj":"T10796"},{"id":"R4307","pred":"dobj","subj":"T10797","obj":"T10796"},{"id":"R4308","pred":"mark","subj":"T10798","obj":"T10799"},{"id":"R4309","pred":"acl","subj":"T10799","obj":"T10797"},{"id":"R4310","pred":"det","subj":"T10800","obj":"T10801"},{"id":"R4311","pred":"nsubj","subj":"T10801","obj":"T10799"},{"id":"R4312","pred":"amod","subj":"T10802","obj":"T10801"},{"id":"R4313","pred":"prep","subj":"T10803","obj":"T10801"},{"id":"R4314","pred":"compound","subj":"T10804","obj":"T10805"},{"id":"R4315","pred":"compound","subj":"T10805","obj":"T10806"},{"id":"R4316","pred":"pobj","subj":"T10806","obj":"T10803"},{"id":"R4317","pred":"acomp","subj":"T10807","obj":"T10799"},{"id":"R4318","pred":"prep","subj":"T10808","obj":"T10807"},{"id":"R4319","pred":"amod","subj":"T10809","obj":"T10810"},{"id":"R4320","pred":"pobj","subj":"T10810","obj":"T10808"},{"id":"R4321","pred":"amod","subj":"T10811","obj":"T10810"},{"id":"R4322","pred":"prep","subj":"T10812","obj":"T10810"},{"id":"R4323","pred":"amod","subj":"T10813","obj":"T10814"},{"id":"R4324","pred":"pobj","subj":"T10814","obj":"T10812"},{"id":"R4325","pred":"cc","subj":"T10815","obj":"T10814"},{"id":"R4326","pred":"compound","subj":"T10816","obj":"T10817"},{"id":"R4327","pred":"conj","subj":"T10817","obj":"T10814"},{"id":"R4328","pred":"punct","subj":"T10818","obj":"T10796"},{"id":"R4329","pred":"poss","subj":"T10820","obj":"T10821"},{"id":"R4330","pred":"nsubj","subj":"T10821","obj":"T10822"},{"id":"R4331","pred":"mark","subj":"T10823","obj":"T10824"},{"id":"R4332","pred":"ccomp","subj":"T10824","obj":"T10822"},{"id":"R4333","pred":"compound","subj":"T10825","obj":"T10826"},{"id":"R4334","pred":"nsubj","subj":"T10826","obj":"T10824"},{"id":"R4335","pred":"det","subj":"T10827","obj":"T10828"},{"id":"R4336","pred":"dobj","subj":"T10828","obj":"T10824"},{"id":"R4337","pred":"amod","subj":"T10829","obj":"T10828"},{"id":"R4338","pred":"prep","subj":"T10830","obj":"T10828"},{"id":"R4339","pred":"poss","subj":"T10831","obj":"T10832"},{"id":"R4340","pred":"pobj","subj":"T10832","obj":"T10830"},{"id":"R4341","pred":"aux","subj":"T10833","obj":"T10834"},{"id":"R4342","pred":"advcl","subj":"T10834","obj":"T10824"},{"id":"R4343","pred":"prep","subj":"T10835","obj":"T10834"},{"id":"R4344","pred":"compound","subj":"T10836","obj":"T10837"},{"id":"R4345","pred":"pobj","subj":"T10837","obj":"T10835"},{"id":"R4346","pred":"compound","subj":"T10838","obj":"T10839"},{"id":"R4347","pred":"compound","subj":"T10839","obj":"T10837"},{"id":"R4348","pred":"punct","subj":"T10840","obj":"T10824"},{"id":"R4349","pred":"mark","subj":"T10841","obj":"T10842"},{"id":"R4350","pred":"advcl","subj":"T10842","obj":"T10824"},{"id":"R4351","pred":"prep","subj":"T10843","obj":"T10842"},{"id":"R4352","pred":"pobj","subj":"T10844","obj":"T10843"},{"id":"R4353","pred":"prep","subj":"T10845","obj":"T10844"},{"id":"R4354","pred":"compound","subj":"T10846","obj":"T10847"},{"id":"R4355","pred":"pobj","subj":"T10847","obj":"T10845"},{"id":"R4356","pred":"cc","subj":"T10848","obj":"T10847"},{"id":"R4357","pred":"amod","subj":"T10849","obj":"T10850"},{"id":"R4358","pred":"conj","subj":"T10850","obj":"T10847"},{"id":"R4359","pred":"compound","subj":"T10851","obj":"T10850"},{"id":"R4360","pred":"punct","subj":"T10852","obj":"T10853"},{"id":"R4361","pred":"parataxis","subj":"T10853","obj":"T10824"},{"id":"R4362","pred":"nummod","subj":"T10854","obj":"T10853"},{"id":"R4363","pred":"punct","subj":"T10855","obj":"T10853"},{"id":"R4364","pred":"punct","subj":"T10856","obj":"T10822"},{"id":"R4365","pred":"poss","subj":"T10858","obj":"T10859"},{"id":"R4366","pred":"nsubj","subj":"T10859","obj":"T10860"},{"id":"R4367","pred":"prep","subj":"T10861","obj":"T10860"},{"id":"R4368","pred":"det","subj":"T10862","obj":"T10863"},{"id":"R4369","pred":"pobj","subj":"T10863","obj":"T10861"},{"id":"R4370","pred":"prep","subj":"T10864","obj":"T10863"},{"id":"R4371","pred":"npadvmod","subj":"T10865","obj":"T10866"},{"id":"R4372","pred":"amod","subj":"T10866","obj":"T10868"},{"id":"R4373","pred":"punct","subj":"T10867","obj":"T10866"},{"id":"R4374","pred":"pobj","subj":"T10868","obj":"T10864"},{"id":"R4375","pred":"punct","subj":"T10869","obj":"T10866"},{"id":"R4376","pred":"cc","subj":"T10870","obj":"T10866"},{"id":"R4377","pred":"advmod","subj":"T10871","obj":"T10870"},{"id":"R4378","pred":"advmod","subj":"T10872","obj":"T10873"},{"id":"R4379","pred":"conj","subj":"T10873","obj":"T10866"},{"id":"R4380","pred":"punct","subj":"T10874","obj":"T10868"},{"id":"R4381","pred":"prep","subj":"T10875","obj":"T10868"},{"id":"R4382","pred":"compound","subj":"T10876","obj":"T10877"},{"id":"R4383","pred":"pobj","subj":"T10877","obj":"T10875"},{"id":"R4384","pred":"compound","subj":"T10878","obj":"T10879"},{"id":"R4385","pred":"compound","subj":"T10879","obj":"T10877"},{"id":"R4386","pred":"punct","subj":"T10880","obj":"T10860"},{"id":"R4387","pred":"advmod","subj":"T10882","obj":"T10883"},{"id":"R4388","pred":"advmod","subj":"T10883","obj":"T10884"},{"id":"R4389","pred":"punct","subj":"T10885","obj":"T10884"},{"id":"R4390","pred":"nsubj","subj":"T10886","obj":"T10884"},{"id":"R4391","pred":"mark","subj":"T10887","obj":"T10888"},{"id":"R4392","pred":"ccomp","subj":"T10888","obj":"T10884"},{"id":"R4393","pred":"advmod","subj":"T10889","obj":"T10890"},{"id":"R4394","pred":"amod","subj":"T10890","obj":"T10891"},{"id":"R4395","pred":"nsubj","subj":"T10891","obj":"T10888"},{"id":"R4396","pred":"prep","subj":"T10892","obj":"T10891"},{"id":"R4397","pred":"amod","subj":"T10893","obj":"T10894"},{"id":"R4398","pred":"pobj","subj":"T10894","obj":"T10892"},{"id":"R4399","pred":"acl","subj":"T10895","obj":"T10891"},{"id":"R4400","pred":"prep","subj":"T10896","obj":"T10895"},{"id":"R4401","pred":"det","subj":"T10897","obj":"T10898"},{"id":"R4402","pred":"pobj","subj":"T10898","obj":"T10896"},{"id":"R4403","pred":"amod","subj":"T10899","obj":"T10898"},{"id":"R4404","pred":"acl","subj":"T10900","obj":"T10898"},{"id":"R4405","pred":"prep","subj":"T10901","obj":"T10900"},{"id":"R4406","pred":"pobj","subj":"T10902","obj":"T10901"},{"id":"R4407","pred":"prep","subj":"T10903","obj":"T10900"},{"id":"R4408","pred":"amod","subj":"T10904","obj":"T10905"},{"id":"R4409","pred":"pobj","subj":"T10905","obj":"T10903"},{"id":"R4410","pred":"amod","subj":"T10906","obj":"T10905"},{"id":"R4411","pred":"det","subj":"T10907","obj":"T10908"},{"id":"R4412","pred":"dobj","subj":"T10908","obj":"T10888"},{"id":"R4413","pred":"amod","subj":"T10909","obj":"T10908"},{"id":"R4414","pred":"prep","subj":"T10910","obj":"T10908"},{"id":"R4415","pred":"amod","subj":"T10911","obj":"T10912"},{"id":"R4416","pred":"pobj","subj":"T10912","obj":"T10910"},{"id":"R4417","pred":"punct","subj":"T10913","obj":"T10884"}],"text":"Target-derived signals exhibit a conserved role in the induction of defined programs of transcription factor expression late in post-mitotic neuronal differentiation [10]. This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). Our findings argue for the necessity of target-induced, and therefore temporally controlled, upregulation of ETS transcription factor signaling. More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T10559","span":{"begin":33,"end":42},"obj":"SO_EXT:biological_conservation_process_or_quality"},{"id":"T10560","span":{"begin":88,"end":101},"obj":"GO_EXT:transcription"},{"id":"T10561","span":{"begin":88,"end":108},"obj":"GO_EXT:transcription_factor"},{"id":"T10562","span":{"begin":109,"end":119},"obj":"GO:0010467"},{"id":"T10563","span":{"begin":133,"end":140},"obj":"GO:0007067"},{"id":"T10564","span":{"begin":141,"end":149},"obj":"CL:0000540"},{"id":"T10565","span":{"begin":150,"end":165},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T10566","span":{"begin":224,"end":237},"obj":"GO_EXT:transcription"},{"id":"T10567","span":{"begin":224,"end":244},"obj":"GO_EXT:transcription_factor"},{"id":"T10568","span":{"begin":245,"end":255},"obj":"GO:0010467"},{"id":"T10569","span":{"begin":295,"end":303},"obj":"CL:0000540"},{"id":"T10570","span":{"begin":295,"end":303},"obj":"_FRAGMENT"},{"id":"T10571","span":{"begin":324,"end":331},"obj":"UBERON:0024914"},{"id":"T10572","span":{"begin":304,"end":319},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T10573","span":{"begin":366,"end":369},"obj":"UBERON:0000044"},{"id":"T10574","span":{"begin":370,"end":377},"obj":"CL:0000540"},{"id":"T10575","span":{"begin":427,"end":434},"obj":"GO_EXT:reaction_or_response"},{"id":"T10576","span":{"begin":442,"end":455},"obj":"GO_EXT:transcription"},{"id":"T10577","span":{"begin":442,"end":462},"obj":"GO_EXT:transcription_factor"},{"id":"T10578","span":{"begin":463,"end":472},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T10579","span":{"begin":500,"end":504},"obj":"SO_EXT:0000704"},{"id":"T10580","span":{"begin":500,"end":515},"obj":"GO:0010467"},{"id":"T10581","span":{"begin":520,"end":526},"obj":"GO:0030424"},{"id":"T10582","span":{"begin":636,"end":646},"obj":"GO:0065007"},{"id":"T10583","span":{"begin":648,"end":663},"obj":"_FRAGMENT"},{"id":"T10584","span":{"begin":689,"end":698},"obj":"GO:0023056"},{"id":"T10585","span":{"begin":668,"end":681},"obj":"GO_EXT:transcription"},{"id":"T10586","span":{"begin":668,"end":688},"obj":"GO_EXT:transcription_factor"},{"id":"T10587","span":{"begin":745,"end":754},"obj":"GO:0065007"},{"id":"T10588","span":{"begin":769,"end":784},"obj":"GO_EXT:transcription"},{"id":"T10589","span":{"begin":834,"end":841},"obj":"CL:0000540"},{"id":"T10590","span":{"begin":909,"end":917},"obj":"CL:0000540"},{"id":"T10591","span":{"begin":909,"end":928},"obj":"GO:0042551"}],"relations":[{"id":"R4274","pred":"_lexicallyChainedTo","subj":"T10571","obj":"T10570"},{"id":"R4275","pred":"_lexicallyChainedTo","subj":"T10584","obj":"T10583"}],"text":"Target-derived signals exhibit a conserved role in the induction of defined programs of transcription factor expression late in post-mitotic neuronal differentiation [10]. This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). Our findings argue for the necessity of target-induced, and therefore temporally controlled, upregulation of ETS transcription factor signaling. More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation."}

{"project":"2_test","denotations":[{"id":"15836427-15271496-84719648","span":{"begin":167,"end":169},"obj":"15271496"},{"id":"T15332","span":{"begin":167,"end":169},"obj":"15271496"}],"text":"Target-derived signals exhibit a conserved role in the induction of defined programs of transcription factor expression late in post-mitotic neuronal differentiation [10]. This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). Our findings argue for the necessity of target-induced, and therefore temporally controlled, upregulation of ETS transcription factor signaling. More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation."}

{"project":"biosemtest","denotations":[{"id":"T9551","span":{"begin":177,"end":182},"obj":"UMLS/C0947630"},{"id":"T9553","span":{"begin":23,"end":30},"obj":"UMLS/C0015272"},{"id":"T9559","span":{"begin":918,"end":928},"obj":"UMLS/C1254042"},{"id":"T9563","span":{"begin":424,"end":426},"obj":"UMLS/C0319022"},{"id":"T9564","span":{"begin":802,"end":804},"obj":"UMLS/C0319022"},{"id":"T9587","span":{"begin":366,"end":369},"obj":"UMLS/C1537672"},{"id":"T9598","span":{"begin":477,"end":485},"obj":"UMLS/C1516048"},{"id":"T9600","span":{"begin":177,"end":182},"obj":"UMLS/C1880229"},{"id":"T9605","span":{"begin":141,"end":165},"obj":"UMLS/C1518294"},{"id":"T9606","span":{"begin":295,"end":319},"obj":"UMLS/C1518294"},{"id":"T9608","span":{"begin":215,"end":220},"obj":"UMLS/C1299997"},{"id":"T9619","span":{"begin":109,"end":119},"obj":"UMLS/C0017262"},{"id":"T9620","span":{"begin":245,"end":255},"obj":"UMLS/C0017262"},{"id":"T9621","span":{"begin":500,"end":515},"obj":"UMLS/C0017262"},{"id":"T9645","span":{"begin":76,"end":84},"obj":"UMLS/C0205539"},{"id":"T9646","span":{"begin":785,"end":793},"obj":"UMLS/C0205539"},{"id":"T9668","span":{"begin":177,"end":182},"obj":"UMLS/C0008976"},{"id":"T9670","span":{"begin":534,"end":542},"obj":"UMLS/C2699153"},{"id":"T9673","span":{"begin":177,"end":182},"obj":"UMLS/C0008972"},{"id":"T9677","span":{"begin":755,"end":765},"obj":"UMLS/C1879547"},{"id":"T9682","span":{"begin":7,"end":14},"obj":"UMLS/C1711343"},{"id":"T9689","span":{"begin":109,"end":119},"obj":"UMLS/C0185117"},{"id":"T9690","span":{"begin":245,"end":255},"obj":"UMLS/C0185117"},{"id":"T9706","span":{"begin":43,"end":47},"obj":"UMLS/C0035820"},{"id":"T9725","span":{"begin":43,"end":47},"obj":"UMLS/C1705811"},{"id":"T9726","span":{"begin":388,"end":396},"obj":"UMLS/C0205374"},{"id":"T9729","span":{"begin":43,"end":47},"obj":"UMLS/C1705810"},{"id":"T9732","span":{"begin":43,"end":47},"obj":"UMLS/C1705812"},{"id":"T9738","span":{"begin":43,"end":47},"obj":"UMLS/C1705809"},{"id":"T9739","span":{"begin":177,"end":182},"obj":"UMLS/C0557651"},{"id":"T9752","span":{"begin":794,"end":801},"obj":"UMLS/C0010222"},{"id":"T9753","span":{"begin":896,"end":905},"obj":"UMLS/C0441712"},{"id":"T9758","span":{"begin":332,"end":341},"obj":"UMLS/C1522492"},{"id":"T9790","span":{"begin":347,"end":351},"obj":"UMLS/C1511726"},{"id":"T9791","span":{"begin":332,"end":341},"obj":"UMLS/C0439634"},{"id":"T9799","span":{"begin":177,"end":182},"obj":"UMLS/C1705923"},{"id":"T9805","span":{"begin":7,"end":14},"obj":"UMLS/C2348040"},{"id":"T9814","span":{"begin":55,"end":64},"obj":"UMLS/C1621983"},{"id":"T9821","span":{"begin":648,"end":660},"obj":"UMLS/C0041904"},{"id":"T9824","span":{"begin":259,"end":268},"obj":"UMLS/C0205224"},{"id":"T9827","span":{"begin":284,"end":291},"obj":"UMLS/C0700364"},{"id":"T9835","span":{"begin":15,"end":22},"obj":"UMLS/C1710082"},{"id":"T9836","span":{"begin":463,"end":472},"obj":"UMLS/C1710082"},{"id":"T9837","span":{"begin":689,"end":698},"obj":"UMLS/C1710082"},{"id":"T9848","span":{"begin":851,"end":871},"obj":"UMLS/C0870411"},{"id":"T9849","span":{"begin":55,"end":64},"obj":"UMLS/C0205263"},{"id":"T9850","span":{"begin":602,"end":609},"obj":"UMLS/C0205263"},{"id":"T9851","span":{"begin":823,"end":830},"obj":"UMLS/C0205263"},{"id":"T9861","span":{"begin":0,"end":6},"obj":"UMLS/C0599894"},{"id":"T9862","span":{"begin":527,"end":533},"obj":"UMLS/C0599894"},{"id":"T9863","span":{"begin":595,"end":601},"obj":"UMLS/C0599894"},{"id":"T9879","span":{"begin":636,"end":646},"obj":"UMLS/C0332298"},{"id":"T9889","span":{"begin":68,"end":75},"obj":"UMLS/C1704788"},{"id":"T9894","span":{"begin":397,"end":403},"obj":"UMLS/C0025320"},{"id":"T9895","span":{"begin":489,"end":496},"obj":"UMLS/C0025320"},{"id":"T9901","span":{"begin":7,"end":14},"obj":"UMLS/C1441547"},{"id":"T9914","span":{"begin":366,"end":369},"obj":"UMLS/C0011928"},{"id":"T9929","span":{"begin":636,"end":646},"obj":"UMLS/C1882979"},{"id":"T9965","span":{"begin":192,"end":200},"obj":"UMLS/C0332120"},{"id":"T9968","span":{"begin":120,"end":124},"obj":"UMLS/C0205087"},{"id":"T9969","span":{"begin":210,"end":214},"obj":"UMLS/C0205087"},{"id":"T9970","span":{"begin":278,"end":283},"obj":"UMLS/C0205087"},{"id":"T9975","span":{"begin":183,"end":191},"obj":"UMLS/C0359589"},{"id":"T9984","span":{"begin":721,"end":728},"obj":"UMLS/C1705535"},{"id":"T9985","span":{"begin":438,"end":441},"obj":"UMLS/C0812380"},{"id":"T9986","span":{"begin":664,"end":667},"obj":"UMLS/C0812380"},{"id":"T9997","span":{"begin":388,"end":396},"obj":"UMLS/C2362314"},{"id":"T10008","span":{"begin":284,"end":291},"obj":"UMLS/C1879746"},{"id":"T10010","span":{"begin":397,"end":403},"obj":"UMLS/C0392747"},{"id":"T10011","span":{"begin":489,"end":496},"obj":"UMLS/C0392747"},{"id":"T10021","span":{"begin":215,"end":220},"obj":"UMLS/C0332162"},{"id":"T10029","span":{"begin":700,"end":704},"obj":"UMLS/C0205172"},{"id":"T10048","span":{"begin":352,"end":360},"obj":"UMLS/C1444656"},{"id":"T10052","span":{"begin":88,"end":108},"obj":"UMLS/C0040648"},{"id":"T10053","span":{"begin":224,"end":244},"obj":"UMLS/C0040648"},{"id":"T10054","span":{"begin":442,"end":462},"obj":"UMLS/C0040648"},{"id":"T10055","span":{"begin":668,"end":688},"obj":"UMLS/C0040648"},{"id":"T10075","span":{"begin":769,"end":784},"obj":"UMLS/C0040649"},{"id":"T10096","span":{"begin":177,"end":182},"obj":"UMLS/C2349977"},{"id":"T10099","span":{"begin":636,"end":646},"obj":"UMLS/C0009932"},{"id":"T10108","span":{"begin":177,"end":182},"obj":"UMLS/C2603343"},{"id":"T10110","span":{"begin":794,"end":801},"obj":"UMLS/C1948027"},{"id":"T10111","span":{"begin":438,"end":441},"obj":"UMLS/C1705691"},{"id":"T10112","span":{"begin":664,"end":667},"obj":"UMLS/C1705691"},{"id":"T10148","span":{"begin":332,"end":341},"obj":"UMLS/C0220781"},{"id":"T10163","span":{"begin":559,"end":567},"obj":"UMLS/C2607943"},{"id":"T10178","span":{"begin":370,"end":377},"obj":"UMLS/C0027882"},{"id":"T10179","span":{"begin":834,"end":841},"obj":"UMLS/C0027882"},{"id":"T10188","span":{"begin":397,"end":403},"obj":"UMLS/C1705241"},{"id":"T10189","span":{"begin":489,"end":496},"obj":"UMLS/C1705241"},{"id":"T10202","span":{"begin":636,"end":646},"obj":"UMLS/C1550141"},{"id":"T10211","span":{"begin":76,"end":84},"obj":"UMLS/C1709697"},{"id":"T10212","span":{"begin":785,"end":793},"obj":"UMLS/C1709697"},{"id":"T10219","span":{"begin":397,"end":403},"obj":"UMLS/C0443172"},{"id":"T10220","span":{"begin":489,"end":496},"obj":"UMLS/C0443172"},{"id":"T10224","span":{"begin":896,"end":905},"obj":"UMLS/C1706376"},{"id":"T10233","span":{"begin":366,"end":369},"obj":"UMLS/C1414151"},{"id":"T10239","span":{"begin":273,"end":277},"obj":"UMLS/C0439064"},{"id":"T10240","span":{"begin":700,"end":704},"obj":"UMLS/C0439064"},{"id":"T10249","span":{"begin":427,"end":437},"obj":"UMLS/C1553423"},{"id":"T10251","span":{"begin":43,"end":47},"obj":"UMLS/C1704326"},{"id":"T10252","span":{"begin":636,"end":646},"obj":"UMLS/C1547100"},{"id":"T10270","span":{"begin":15,"end":22},"obj":"UMLS/C0037083"},{"id":"T10271","span":{"begin":463,"end":472},"obj":"UMLS/C0037083"},{"id":"T10272","span":{"begin":689,"end":698},"obj":"UMLS/C0037083"},{"id":"T10284","span":{"begin":845,"end":850},"obj":"UMLS/C1279919"},{"id":"T10297","span":{"begin":636,"end":646},"obj":"UMLS/C0243148"},{"id":"T10314","span":{"begin":120,"end":124},"obj":"UMLS/C1279941"},{"id":"T10315","span":{"begin":210,"end":214},"obj":"UMLS/C1279941"},{"id":"T10316","span":{"begin":278,"end":283},"obj":"UMLS/C1279941"},{"id":"T10323","span":{"begin":284,"end":291},"obj":"UMLS/C1547011"},{"id":"T10326","span":{"begin":534,"end":542},"obj":"UMLS/C1269955"},{"id":"T10328","span":{"begin":0,"end":6},"obj":"UMLS/C1521840"},{"id":"T10329","span":{"begin":527,"end":533},"obj":"UMLS/C1521840"},{"id":"T10330","span":{"begin":595,"end":601},"obj":"UMLS/C1521840"},{"id":"T10347","span":{"begin":909,"end":917},"obj":"UMLS/C0521390"},{"id":"T10361","span":{"begin":413,"end":423},"obj":"UMLS/C0086035"},{"id":"T10375","span":{"begin":76,"end":84},"obj":"UMLS/C0376691"},{"id":"T10376","span":{"begin":785,"end":793},"obj":"UMLS/C0376691"},{"id":"T10385","span":{"begin":438,"end":441},"obj":"UMLS/C0813971"},{"id":"T10386","span":{"begin":664,"end":667},"obj":"UMLS/C0813971"},{"id":"T10405","span":{"begin":745,"end":754},"obj":"UMLS/C0851285"},{"id":"T10411","span":{"begin":388,"end":396},"obj":"UMLS/C0442043"},{"id":"T10414","span":{"begin":636,"end":646},"obj":"UMLS/C2587213"},{"id":"T10427","span":{"begin":172,"end":176},"obj":"UMLS/C0323983"}],"text":"Target-derived signals exhibit a conserved role in the induction of defined programs of transcription factor expression late in post-mitotic neuronal differentiation [10]. This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). Our findings argue for the necessity of target-induced, and therefore temporally controlled, upregulation of ETS transcription factor signaling. More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T10431","span":{"begin":109,"end":119},"obj":"GO:0010467"},{"id":"T10432","span":{"begin":133,"end":140},"obj":"GO:0007067"},{"id":"T10433","span":{"begin":141,"end":149},"obj":"CL:0000540"},{"id":"T10434","span":{"begin":245,"end":255},"obj":"GO:0010467"},{"id":"T10435","span":{"begin":295,"end":303},"obj":"CL:0000540"},{"id":"T10436","span":{"begin":295,"end":303},"obj":"_FRAGMENT"},{"id":"T10437","span":{"begin":324,"end":331},"obj":"UBERON:0024914"},{"id":"T10438","span":{"begin":366,"end":369},"obj":"UBERON:0000044"},{"id":"T10439","span":{"begin":370,"end":377},"obj":"CL:0000540"},{"id":"T10440","span":{"begin":500,"end":504},"obj":"SO:0000704"},{"id":"T10441","span":{"begin":500,"end":515},"obj":"GO:0010467"},{"id":"T10442","span":{"begin":520,"end":526},"obj":"GO:0030424"},{"id":"T10443","span":{"begin":636,"end":646},"obj":"GO:0065007"},{"id":"T10444","span":{"begin":648,"end":663},"obj":"_FRAGMENT"},{"id":"T10445","span":{"begin":689,"end":698},"obj":"GO:0023056"},{"id":"T10446","span":{"begin":745,"end":754},"obj":"GO:0065007"},{"id":"T10447","span":{"begin":834,"end":841},"obj":"CL:0000540"},{"id":"T10448","span":{"begin":909,"end":917},"obj":"CL:0000540"},{"id":"T10449","span":{"begin":909,"end":928},"obj":"GO:0042551"}],"relations":[{"id":"R4267","pred":"_lexicallyChainedTo","subj":"T10437","obj":"T10436"},{"id":"R4268","pred":"_lexicallyChainedTo","subj":"T10445","obj":"T10444"}],"text":"Target-derived signals exhibit a conserved role in the induction of defined programs of transcription factor expression late in post-mitotic neuronal differentiation [10]. This study provides evidence that the late onset of transcription factor expression is essential for many later aspects of neuronal differentiation and circuit formation. Our data indicate that DRG neurons undergo a temporal change in their competence to respond to ETS transcription factor signaling, as assessed by changes in gene expression and axonal target invasion (Figure 9). Our findings argue for the necessity of target-induced, and therefore temporally controlled, upregulation of ETS transcription factor signaling. More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation."}