| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1510 |
13-21 |
JJ |
denotes |
Neuronal |
| T1511 |
22-37 |
NN |
denotes |
differentiation |
| T1512 |
38-40 |
VBZ |
denotes |
is |
| T1513 |
41-42 |
DT |
denotes |
a |
| T1514 |
54-61 |
NN |
denotes |
process |
| T1515 |
43-53 |
JJ |
denotes |
protracted |
| T1516 |
62-68 |
IN |
denotes |
during |
| T1517 |
99-106 |
VBP |
denotes |
express |
| T1518 |
69-74 |
WDT |
denotes |
which |
| T1519 |
75-80 |
RB |
denotes |
newly |
| T1520 |
81-90 |
VBN |
denotes |
generated |
| T1521 |
91-98 |
NNS |
denotes |
neurons |
| T1522 |
107-115 |
JJ |
denotes |
distinct |
| T1523 |
139-147 |
NNS |
denotes |
programs |
| T1524 |
116-124 |
JJ |
denotes |
cellular |
| T1525 |
125-128 |
CC |
denotes |
and |
| T1526 |
129-138 |
JJ |
denotes |
molecular |
| T1527 |
148-150 |
IN |
denotes |
at |
| T1528 |
151-158 |
JJ |
denotes |
precise |
| T1529 |
159-164 |
NNS |
denotes |
times |
| T1530 |
165-171 |
IN |
denotes |
during |
| T1531 |
172-177 |
PRP$ |
denotes |
their |
| T1532 |
178-188 |
NN |
denotes |
maturation |
| T1533 |
188-190 |
: |
denotes |
: |
| T1534 |
190-194 |
JJ |
denotes |
long |
| T1535 |
195-203 |
NN |
denotes |
distance |
| T1536 |
194-195 |
HYPH |
denotes |
- |
| T1537 |
209-218 |
NN |
denotes |
outgrowth |
| T1538 |
204-208 |
NN |
denotes |
axon |
| T1539 |
218-220 |
, |
denotes |
, |
| T1540 |
220-230 |
JJ |
denotes |
subsequent |
| T1541 |
240-249 |
NN |
denotes |
branching |
| T1542 |
231-239 |
JJ |
denotes |
terminal |
| T1543 |
249-251 |
, |
denotes |
, |
| T1544 |
251-254 |
CC |
denotes |
and |
| T1545 |
255-262 |
RB |
denotes |
finally |
| T1546 |
263-277 |
NN |
denotes |
synaptogenesis |
| T1547 |
277-278 |
. |
denotes |
. |
| T1548 |
278-494 |
sentence |
denotes |
Many important aspects of neuronal character appear to be acquired through the expression of transcription factors at progenitor cell stages, whereas others depend on expression immediately upon cell cycle exit [1]. |
| T1549 |
279-283 |
JJ |
denotes |
Many |
| T1550 |
294-301 |
NNS |
denotes |
aspects |
| T1551 |
284-293 |
JJ |
denotes |
important |
| T1552 |
324-330 |
VBP |
denotes |
appear |
| T1553 |
302-304 |
IN |
denotes |
of |
| T1554 |
305-313 |
JJ |
denotes |
neuronal |
| T1555 |
314-323 |
NN |
denotes |
character |
| T1556 |
331-333 |
TO |
denotes |
to |
| T1557 |
337-345 |
VBN |
denotes |
acquired |
| T1558 |
334-336 |
VB |
denotes |
be |
| T1559 |
346-353 |
IN |
denotes |
through |
| T1560 |
354-357 |
DT |
denotes |
the |
| T1561 |
358-368 |
NN |
denotes |
expression |
| T1562 |
369-371 |
IN |
denotes |
of |
| T1563 |
372-385 |
NN |
denotes |
transcription |
| T1564 |
386-393 |
NNS |
denotes |
factors |
| T1565 |
394-396 |
IN |
denotes |
at |
| T1566 |
397-407 |
NN |
denotes |
progenitor |
| T1567 |
413-419 |
NNS |
denotes |
stages |
| T1568 |
408-412 |
NN |
denotes |
cell |
| T1569 |
419-421 |
, |
denotes |
, |
| T1570 |
421-428 |
IN |
denotes |
whereas |
| T1571 |
436-442 |
VBP |
denotes |
depend |
| T1572 |
429-435 |
NNS |
denotes |
others |
| T1573 |
443-445 |
IN |
denotes |
on |
| T1574 |
446-456 |
NN |
denotes |
expression |
| T1575 |
457-468 |
RB |
denotes |
immediately |
| T1576 |
469-473 |
IN |
denotes |
upon |
| T1577 |
474-478 |
NN |
denotes |
cell |
| T1578 |
479-484 |
NN |
denotes |
cycle |
| T1579 |
485-489 |
NN |
denotes |
exit |
| T1580 |
490-491 |
-LRB- |
denotes |
[ |
| T1581 |
491-492 |
CD |
denotes |
1 |
| T1582 |
492-493 |
-RRB- |
denotes |
] |
| T1583 |
493-494 |
. |
denotes |
. |
| T1584 |
494-747 |
sentence |
denotes |
But whether the orderly expression and activity of transcriptional programs at much later developmental stages, well after cell cycle exit, is an essential step in the progression of neuronal differentiation and circuit assembly has yet to be resolved. |
| T1585 |
495-498 |
CC |
denotes |
But |
| T1586 |
724-727 |
VBZ |
denotes |
has |
| T1587 |
499-506 |
IN |
denotes |
whether |
| T1588 |
635-637 |
VBZ |
denotes |
is |
| T1589 |
507-510 |
DT |
denotes |
the |
| T1590 |
519-529 |
NN |
denotes |
expression |
| T1591 |
511-518 |
JJ |
denotes |
orderly |
| T1592 |
530-533 |
CC |
denotes |
and |
| T1593 |
534-542 |
NN |
denotes |
activity |
| T1594 |
543-545 |
IN |
denotes |
of |
| T1595 |
546-561 |
JJ |
denotes |
transcriptional |
| T1596 |
562-570 |
NNS |
denotes |
programs |
| T1597 |
571-573 |
IN |
denotes |
at |
| T1598 |
574-578 |
RB |
denotes |
much |
| T1599 |
579-584 |
JJ |
denotes |
later |
| T1600 |
599-605 |
NNS |
denotes |
stages |
| T1601 |
585-598 |
JJ |
denotes |
developmental |
| T1602 |
605-607 |
, |
denotes |
, |
| T1603 |
607-611 |
RB |
denotes |
well |
| T1604 |
612-617 |
IN |
denotes |
after |
| T1605 |
618-622 |
NN |
denotes |
cell |
| T1606 |
623-628 |
NN |
denotes |
cycle |
| T1607 |
629-633 |
NN |
denotes |
exit |
| T1608 |
633-635 |
, |
denotes |
, |
| T1609 |
638-640 |
DT |
denotes |
an |
| T1610 |
651-655 |
NN |
denotes |
step |
| T1611 |
641-650 |
JJ |
denotes |
essential |
| T1612 |
656-658 |
IN |
denotes |
in |
| T1613 |
659-662 |
DT |
denotes |
the |
| T1614 |
663-674 |
NN |
denotes |
progression |
| T1615 |
675-677 |
IN |
denotes |
of |
| T1616 |
678-686 |
JJ |
denotes |
neuronal |
| T1617 |
687-702 |
NN |
denotes |
differentiation |
| T1618 |
703-706 |
CC |
denotes |
and |
| T1619 |
707-714 |
NN |
denotes |
circuit |
| T1620 |
715-723 |
NN |
denotes |
assembly |
| T1621 |
728-731 |
RB |
denotes |
yet |
| T1622 |
732-734 |
TO |
denotes |
to |
| T1623 |
738-746 |
VBN |
denotes |
resolved |
| T1624 |
735-737 |
VB |
denotes |
be |
| T1625 |
746-747 |
. |
denotes |
. |
| T1626 |
747-1023 |
sentence |
denotes |
The differentiation of sensory neurons of dorsal root ganglia (DRG) has been studied extensively with respect to inductive events that specify neuronal fate [2,3], as well as the involvement of late target-derived neurotrophic factors in the control of neuronal survival [4]. |
| T1627 |
748-751 |
DT |
denotes |
The |
| T1628 |
752-767 |
NN |
denotes |
differentiation |
| T1629 |
825-832 |
VBN |
denotes |
studied |
| T1630 |
768-770 |
IN |
denotes |
of |
| T1631 |
771-778 |
JJ |
denotes |
sensory |
| T1632 |
779-786 |
NNS |
denotes |
neurons |
| T1633 |
787-789 |
IN |
denotes |
of |
| T1634 |
790-796 |
JJ |
denotes |
dorsal |
| T1635 |
802-809 |
NNS |
denotes |
ganglia |
| T1636 |
797-801 |
NN |
denotes |
root |
| T1637 |
810-811 |
-LRB- |
denotes |
( |
| T1638 |
811-814 |
NN |
denotes |
DRG |
| T1639 |
814-815 |
-RRB- |
denotes |
) |
| T1640 |
816-819 |
VBZ |
denotes |
has |
| T1641 |
820-824 |
VBN |
denotes |
been |
| T1642 |
833-844 |
RB |
denotes |
extensively |
| T1643 |
845-849 |
IN |
denotes |
with |
| T1644 |
850-857 |
NN |
denotes |
respect |
| T1645 |
858-860 |
IN |
denotes |
to |
| T1646 |
861-870 |
JJ |
denotes |
inductive |
| T1647 |
871-877 |
NNS |
denotes |
events |
| T1648 |
878-882 |
WDT |
denotes |
that |
| T1649 |
883-890 |
VBP |
denotes |
specify |
| T1650 |
891-899 |
JJ |
denotes |
neuronal |
| T1651 |
900-904 |
NN |
denotes |
fate |
| T1652 |
905-906 |
-LRB- |
denotes |
[ |
| T1653 |
908-909 |
CD |
denotes |
3 |
| T1654 |
906-907 |
CD |
denotes |
2 |
| T1655 |
907-908 |
, |
denotes |
, |
| T1656 |
909-910 |
-RRB- |
denotes |
] |
| T1657 |
910-912 |
, |
denotes |
, |
| T1658 |
912-914 |
RB |
denotes |
as |
| T1659 |
920-922 |
IN |
denotes |
as |
| T1660 |
915-919 |
RB |
denotes |
well |
| T1661 |
923-926 |
DT |
denotes |
the |
| T1662 |
927-938 |
NN |
denotes |
involvement |
| T1663 |
939-941 |
IN |
denotes |
of |
| T1664 |
942-946 |
JJ |
denotes |
late |
| T1665 |
975-982 |
NNS |
denotes |
factors |
| T1666 |
947-953 |
NN |
denotes |
target |
| T1667 |
954-961 |
VBN |
denotes |
derived |
| T1668 |
953-954 |
HYPH |
denotes |
- |
| T1669 |
962-974 |
JJ |
denotes |
neurotrophic |
| T1670 |
983-985 |
IN |
denotes |
in |
| T1671 |
986-989 |
DT |
denotes |
the |
| T1672 |
990-997 |
NN |
denotes |
control |
| T1673 |
998-1000 |
IN |
denotes |
of |
| T1674 |
1001-1009 |
JJ |
denotes |
neuronal |
| T1675 |
1010-1018 |
NN |
denotes |
survival |
| T1676 |
1019-1020 |
-LRB- |
denotes |
[ |
| T1677 |
1020-1021 |
CD |
denotes |
4 |
| T1678 |
1021-1022 |
-RRB- |
denotes |
] |
| T1679 |
1022-1023 |
. |
denotes |
. |
| T1680 |
1023-1170 |
sentence |
denotes |
Recent evidence has begun to emerge that target-derived factors are also involved in regulating later aspects of neuronal differentiation [5,6,7]. |
| T1681 |
1024-1030 |
JJ |
denotes |
Recent |
| T1682 |
1031-1039 |
NN |
denotes |
evidence |
| T1683 |
1044-1049 |
VBN |
denotes |
begun |
| T1684 |
1040-1043 |
VBZ |
denotes |
has |
| T1685 |
1050-1052 |
TO |
denotes |
to |
| T1686 |
1053-1059 |
VB |
denotes |
emerge |
| T1687 |
1060-1064 |
IN |
denotes |
that |
| T1688 |
1097-1105 |
VBN |
denotes |
involved |
| T1689 |
1065-1071 |
NN |
denotes |
target |
| T1690 |
1072-1079 |
VBN |
denotes |
derived |
| T1691 |
1071-1072 |
HYPH |
denotes |
- |
| T1692 |
1080-1087 |
NNS |
denotes |
factors |
| T1693 |
1088-1091 |
VBP |
denotes |
are |
| T1694 |
1092-1096 |
RB |
denotes |
also |
| T1695 |
1106-1108 |
IN |
denotes |
in |
| T1696 |
1109-1119 |
VBG |
denotes |
regulating |
| T1697 |
1120-1125 |
JJ |
denotes |
later |
| T1698 |
1126-1133 |
NNS |
denotes |
aspects |
| T1699 |
1134-1136 |
IN |
denotes |
of |
| T1700 |
1137-1145 |
JJ |
denotes |
neuronal |
| T1701 |
1146-1161 |
NN |
denotes |
differentiation |
| T1702 |
1162-1163 |
-LRB- |
denotes |
[ |
| T1703 |
1167-1168 |
CD |
denotes |
7 |
| T1704 |
1163-1164 |
CD |
denotes |
5 |
| T1705 |
1164-1165 |
, |
denotes |
, |
| T1706 |
1165-1166 |
CD |
denotes |
6 |
| T1707 |
1166-1167 |
, |
denotes |
, |
| T1708 |
1168-1169 |
-RRB- |
denotes |
] |
| T1709 |
1169-1170 |
. |
denotes |
. |
| T1710 |
1170-1420 |
sentence |
denotes |
In particular, genetic experiments have addressed the survival-independent role of neurotrophic factors during development by exploiting strains of mice defective both in neurotrophin signaling and in the function of the proapoptotic gene Bax [8,9]. |
| T1711 |
1171-1173 |
IN |
denotes |
In |
| T1712 |
1211-1220 |
VBN |
denotes |
addressed |
| T1713 |
1174-1184 |
JJ |
denotes |
particular |
| T1714 |
1184-1186 |
, |
denotes |
, |
| T1715 |
1186-1193 |
JJ |
denotes |
genetic |
| T1716 |
1194-1205 |
NNS |
denotes |
experiments |
| T1717 |
1206-1210 |
VBP |
denotes |
have |
| T1718 |
1221-1224 |
DT |
denotes |
the |
| T1719 |
1246-1250 |
NN |
denotes |
role |
| T1720 |
1225-1233 |
NN |
denotes |
survival |
| T1721 |
1234-1245 |
JJ |
denotes |
independent |
| T1722 |
1233-1234 |
HYPH |
denotes |
- |
| T1723 |
1251-1253 |
IN |
denotes |
of |
| T1724 |
1254-1266 |
JJ |
denotes |
neurotrophic |
| T1725 |
1267-1274 |
NNS |
denotes |
factors |
| T1726 |
1275-1281 |
IN |
denotes |
during |
| T1727 |
1282-1293 |
NN |
denotes |
development |
| T1728 |
1294-1296 |
IN |
denotes |
by |
| T1729 |
1297-1307 |
VBG |
denotes |
exploiting |
| T1730 |
1308-1315 |
NNS |
denotes |
strains |
| T1731 |
1316-1318 |
IN |
denotes |
of |
| T1732 |
1319-1323 |
NNS |
denotes |
mice |
| T1733 |
1324-1333 |
JJ |
denotes |
defective |
| T1734 |
1334-1338 |
CC |
denotes |
both |
| T1735 |
1339-1341 |
IN |
denotes |
in |
| T1736 |
1342-1354 |
NN |
denotes |
neurotrophin |
| T1737 |
1355-1364 |
NN |
denotes |
signaling |
| T1738 |
1365-1368 |
CC |
denotes |
and |
| T1739 |
1369-1371 |
IN |
denotes |
in |
| T1740 |
1372-1375 |
DT |
denotes |
the |
| T1741 |
1376-1384 |
NN |
denotes |
function |
| T1742 |
1385-1387 |
IN |
denotes |
of |
| T1743 |
1388-1391 |
DT |
denotes |
the |
| T1744 |
1410-1413 |
NN |
denotes |
Bax |
| T1745 |
1392-1404 |
JJ |
denotes |
proapoptotic |
| T1746 |
1405-1409 |
NN |
denotes |
gene |
| T1747 |
1414-1415 |
-LRB- |
denotes |
[ |
| T1748 |
1417-1418 |
CD |
denotes |
9 |
| T1749 |
1415-1416 |
CD |
denotes |
8 |
| T1750 |
1416-1417 |
, |
denotes |
, |
| T1751 |
1418-1419 |
-RRB- |
denotes |
] |
| T1752 |
1419-1420 |
. |
denotes |
. |
| T1753 |
1420-1609 |
sentence |
denotes |
These studies, for example, have revealed that neurotrophin signaling controls the acquisition of peptidergic traits in nociceptive DRG neurons and the control of target innervation [8,9]. |
| T1754 |
1421-1426 |
DT |
denotes |
These |
| T1755 |
1427-1434 |
NNS |
denotes |
studies |
| T1756 |
1454-1462 |
VBN |
denotes |
revealed |
| T1757 |
1434-1436 |
, |
denotes |
, |
| T1758 |
1436-1439 |
IN |
denotes |
for |
| T1759 |
1440-1447 |
NN |
denotes |
example |
| T1760 |
1447-1449 |
, |
denotes |
, |
| T1761 |
1449-1453 |
VBP |
denotes |
have |
| T1762 |
1463-1467 |
IN |
denotes |
that |
| T1763 |
1491-1499 |
VBZ |
denotes |
controls |
| T1764 |
1468-1480 |
NN |
denotes |
neurotrophin |
| T1765 |
1481-1490 |
NN |
denotes |
signaling |
| T1766 |
1500-1503 |
DT |
denotes |
the |
| T1767 |
1504-1515 |
NN |
denotes |
acquisition |
| T1768 |
1516-1518 |
IN |
denotes |
of |
| T1769 |
1519-1530 |
JJ |
denotes |
peptidergic |
| T1770 |
1531-1537 |
NNS |
denotes |
traits |
| T1771 |
1538-1540 |
IN |
denotes |
in |
| T1772 |
1541-1552 |
JJ |
denotes |
nociceptive |
| T1773 |
1557-1564 |
NNS |
denotes |
neurons |
| T1774 |
1553-1556 |
NN |
denotes |
DRG |
| T1775 |
1565-1568 |
CC |
denotes |
and |
| T1776 |
1569-1572 |
DT |
denotes |
the |
| T1777 |
1573-1580 |
NN |
denotes |
control |
| T1778 |
1581-1583 |
IN |
denotes |
of |
| T1779 |
1584-1590 |
NN |
denotes |
target |
| T1780 |
1591-1602 |
NN |
denotes |
innervation |
| T1781 |
1603-1604 |
-LRB- |
denotes |
[ |
| T1782 |
1606-1607 |
CD |
denotes |
9 |
| T1783 |
1604-1605 |
CD |
denotes |
8 |
| T1784 |
1605-1606 |
, |
denotes |
, |
| T1785 |
1607-1608 |
-RRB- |
denotes |
] |
| T1786 |
1608-1609 |
. |
denotes |
. |
| T1787 |
1609-1742 |
sentence |
denotes |
The onset of some transcriptional programs in neurons, however, has also been shown to occur long after neurons exit the cell cycle. |
| T1788 |
1610-1613 |
DT |
denotes |
The |
| T1789 |
1614-1619 |
NN |
denotes |
onset |
| T1790 |
1688-1693 |
VBN |
denotes |
shown |
| T1791 |
1620-1622 |
IN |
denotes |
of |
| T1792 |
1623-1627 |
DT |
denotes |
some |
| T1793 |
1644-1652 |
NNS |
denotes |
programs |
| T1794 |
1628-1643 |
JJ |
denotes |
transcriptional |
| T1795 |
1653-1655 |
IN |
denotes |
in |
| T1796 |
1656-1663 |
NNS |
denotes |
neurons |
| T1797 |
1663-1665 |
, |
denotes |
, |
| T1798 |
1665-1672 |
RB |
denotes |
however |
| T1799 |
1672-1674 |
, |
denotes |
, |
| T1800 |
1674-1677 |
VBZ |
denotes |
has |
| T1801 |
1678-1682 |
RB |
denotes |
also |
| T1802 |
1683-1687 |
VBN |
denotes |
been |
| T1803 |
1694-1696 |
TO |
denotes |
to |
| T1804 |
1697-1702 |
VB |
denotes |
occur |
| T1805 |
1703-1707 |
RB |
denotes |
long |
| T1806 |
1722-1726 |
VBP |
denotes |
exit |
| T1807 |
1708-1713 |
IN |
denotes |
after |
| T1808 |
1714-1721 |
NNS |
denotes |
neurons |
| T1809 |
1727-1730 |
DT |
denotes |
the |
| T1810 |
1736-1741 |
NN |
denotes |
cycle |
| T1811 |
1731-1735 |
NN |
denotes |
cell |
| T1812 |
1741-1742 |
. |
denotes |
. |
| T1813 |
1742-1912 |
sentence |
denotes |
An emerging principle from work in Drosophila and vertebrates is that target-derived factors play a crucial role in the induction of these transcriptional programs [10]. |
| T1814 |
1743-1745 |
DT |
denotes |
An |
| T1815 |
1755-1764 |
NN |
denotes |
principle |
| T1816 |
1746-1754 |
VBG |
denotes |
emerging |
| T1817 |
1805-1807 |
VBZ |
denotes |
is |
| T1818 |
1765-1769 |
IN |
denotes |
from |
| T1819 |
1770-1774 |
NN |
denotes |
work |
| T1820 |
1775-1777 |
IN |
denotes |
in |
| T1821 |
1778-1788 |
NNP |
denotes |
Drosophila |
| T1822 |
1789-1792 |
CC |
denotes |
and |
| T1823 |
1793-1804 |
NNS |
denotes |
vertebrates |
| T1824 |
1808-1812 |
IN |
denotes |
that |
| T1825 |
1836-1840 |
VBP |
denotes |
play |
| T1826 |
1813-1819 |
NN |
denotes |
target |
| T1827 |
1820-1827 |
VBN |
denotes |
derived |
| T1828 |
1819-1820 |
HYPH |
denotes |
- |
| T1829 |
1828-1835 |
NNS |
denotes |
factors |
| T1830 |
1841-1842 |
DT |
denotes |
a |
| T1831 |
1851-1855 |
NN |
denotes |
role |
| T1832 |
1843-1850 |
JJ |
denotes |
crucial |
| T1833 |
1856-1858 |
IN |
denotes |
in |
| T1834 |
1859-1862 |
DT |
denotes |
the |
| T1835 |
1863-1872 |
NN |
denotes |
induction |
| T1836 |
1873-1875 |
IN |
denotes |
of |
| T1837 |
1876-1881 |
DT |
denotes |
these |
| T1838 |
1898-1906 |
NNS |
denotes |
programs |
| T1839 |
1882-1897 |
JJ |
denotes |
transcriptional |
| T1840 |
1907-1908 |
-LRB- |
denotes |
[ |
| T1841 |
1908-1910 |
CD |
denotes |
10 |
| T1842 |
1910-1911 |
-RRB- |
denotes |
] |
| T1843 |
1911-1912 |
. |
denotes |
. |
| T1844 |
1912-2093 |
sentence |
denotes |
In Drosophila, retrograde BMP signals from the target region control the terminal differentiation of a subpopulation of peptidergic neurons expressing Apterous and Squeeze [11,12]. |
| T1845 |
1913-1915 |
IN |
denotes |
In |
| T1846 |
1974-1981 |
VBP |
denotes |
control |
| T1847 |
1916-1926 |
NNP |
denotes |
Drosophila |
| T1848 |
1926-1928 |
, |
denotes |
, |
| T1849 |
1928-1938 |
JJ |
denotes |
retrograde |
| T1850 |
1943-1950 |
NNS |
denotes |
signals |
| T1851 |
1939-1942 |
NN |
denotes |
BMP |
| T1852 |
1951-1955 |
IN |
denotes |
from |
| T1853 |
1956-1959 |
DT |
denotes |
the |
| T1854 |
1967-1973 |
NN |
denotes |
region |
| T1855 |
1960-1966 |
NN |
denotes |
target |
| T1856 |
1982-1985 |
DT |
denotes |
the |
| T1857 |
1995-2010 |
NN |
denotes |
differentiation |
| T1858 |
1986-1994 |
JJ |
denotes |
terminal |
| T1859 |
2011-2013 |
IN |
denotes |
of |
| T1860 |
2014-2015 |
DT |
denotes |
a |
| T1861 |
2016-2029 |
NN |
denotes |
subpopulation |
| T1862 |
2030-2032 |
IN |
denotes |
of |
| T1863 |
2033-2044 |
JJ |
denotes |
peptidergic |
| T1864 |
2045-2052 |
NNS |
denotes |
neurons |
| T1865 |
2053-2063 |
VBG |
denotes |
expressing |
| T1866 |
2064-2072 |
NN |
denotes |
Apterous |
| T1867 |
2073-2076 |
CC |
denotes |
and |
| T1868 |
2077-2084 |
NN |
denotes |
Squeeze |
| T1869 |
2085-2086 |
-LRB- |
denotes |
[ |
| T1870 |
2089-2091 |
CD |
denotes |
12 |
| T1871 |
2086-2088 |
CD |
denotes |
11 |
| T1872 |
2088-2089 |
, |
denotes |
, |
| T1873 |
2091-2092 |
-RRB- |
denotes |
] |
| T1874 |
2092-2093 |
. |
denotes |
. |
| T1875 |
2093-2359 |
sentence |
denotes |
In vertebrates, peripheral neurotrophic signals have been shown to direct the onset of expression of the ETS transcription factors Er81 and Pea3 in DRG sensory neurons and motor neuron pools several days after these neurons have become post-mitotic [9,13,14,15,16]. |
| T1876 |
2094-2096 |
IN |
denotes |
In |
| T1877 |
2152-2157 |
VBN |
denotes |
shown |
| T1878 |
2097-2108 |
NNS |
denotes |
vertebrates |
| T1879 |
2108-2110 |
, |
denotes |
, |
| T1880 |
2110-2120 |
JJ |
denotes |
peripheral |
| T1881 |
2134-2141 |
NNS |
denotes |
signals |
| T1882 |
2121-2133 |
JJ |
denotes |
neurotrophic |
| T1883 |
2142-2146 |
VBP |
denotes |
have |
| T1884 |
2147-2151 |
VBN |
denotes |
been |
| T1885 |
2158-2160 |
TO |
denotes |
to |
| T1886 |
2161-2167 |
VB |
denotes |
direct |
| T1887 |
2168-2171 |
DT |
denotes |
the |
| T1888 |
2172-2177 |
NN |
denotes |
onset |
| T1889 |
2178-2180 |
IN |
denotes |
of |
| T1890 |
2181-2191 |
NN |
denotes |
expression |
| T1891 |
2192-2194 |
IN |
denotes |
of |
| T1892 |
2195-2198 |
DT |
denotes |
the |
| T1893 |
2217-2224 |
NNS |
denotes |
factors |
| T1894 |
2199-2202 |
NN |
denotes |
ETS |
| T1895 |
2203-2216 |
NN |
denotes |
transcription |
| T1896 |
2225-2229 |
NN |
denotes |
Er81 |
| T1897 |
2230-2233 |
CC |
denotes |
and |
| T1898 |
2234-2238 |
NN |
denotes |
Pea3 |
| T1899 |
2239-2241 |
IN |
denotes |
in |
| T1900 |
2242-2245 |
NN |
denotes |
DRG |
| T1901 |
2254-2261 |
NNS |
denotes |
neurons |
| T1902 |
2246-2253 |
JJ |
denotes |
sensory |
| T1903 |
2262-2265 |
CC |
denotes |
and |
| T1904 |
2266-2271 |
NN |
denotes |
motor |
| T1905 |
2279-2284 |
NNS |
denotes |
pools |
| T1906 |
2272-2278 |
NN |
denotes |
neuron |
| T1907 |
2285-2292 |
JJ |
denotes |
several |
| T1908 |
2293-2297 |
NNS |
denotes |
days |
| T1909 |
2323-2329 |
VBN |
denotes |
become |
| T1910 |
2298-2303 |
IN |
denotes |
after |
| T1911 |
2304-2309 |
DT |
denotes |
these |
| T1912 |
2310-2317 |
NNS |
denotes |
neurons |
| T1913 |
2318-2322 |
VBP |
denotes |
have |
| T1914 |
2330-2342 |
JJ |
denotes |
post-mitotic |
| T1915 |
2343-2344 |
-LRB- |
denotes |
[ |
| T1916 |
2355-2357 |
CD |
denotes |
16 |
| T1917 |
2344-2345 |
CD |
denotes |
9 |
| T1918 |
2345-2346 |
, |
denotes |
, |
| T1919 |
2346-2348 |
CD |
denotes |
13 |
| T1920 |
2348-2349 |
, |
denotes |
, |
| T1921 |
2349-2351 |
CD |
denotes |
14 |
| T1922 |
2351-2352 |
, |
denotes |
, |
| T1923 |
2352-2354 |
CD |
denotes |
15 |
| T1924 |
2354-2355 |
, |
denotes |
, |
| T1925 |
2357-2358 |
-RRB- |
denotes |
] |
| T1926 |
2358-2359 |
. |
denotes |
. |
| T1927 |
2359-2495 |
sentence |
denotes |
Moreover, the induction of Er81 expression in proprioceptive afferents is known to be mediated by peripheral neurotrophin 3 (NT-3) [9]. |
| T1928 |
2360-2368 |
RB |
denotes |
Moreover |
| T1929 |
2434-2439 |
VBN |
denotes |
known |
| T1930 |
2368-2370 |
, |
denotes |
, |
| T1931 |
2370-2373 |
DT |
denotes |
the |
| T1932 |
2374-2383 |
NN |
denotes |
induction |
| T1933 |
2384-2386 |
IN |
denotes |
of |
| T1934 |
2387-2391 |
NN |
denotes |
Er81 |
| T1935 |
2392-2402 |
NN |
denotes |
expression |
| T1936 |
2403-2405 |
IN |
denotes |
in |
| T1937 |
2406-2420 |
JJ |
denotes |
proprioceptive |
| T1938 |
2421-2430 |
NNS |
denotes |
afferents |
| T1939 |
2431-2433 |
VBZ |
denotes |
is |
| T1940 |
2440-2442 |
TO |
denotes |
to |
| T1941 |
2446-2454 |
VBN |
denotes |
mediated |
| T1942 |
2443-2445 |
VB |
denotes |
be |
| T1943 |
2455-2457 |
IN |
denotes |
by |
| T1944 |
2458-2468 |
JJ |
denotes |
peripheral |
| T1945 |
2469-2481 |
NN |
denotes |
neurotrophin |
| T1946 |
2482-2483 |
CD |
denotes |
3 |
| T1947 |
2484-2485 |
-LRB- |
denotes |
( |
| T1948 |
2485-2487 |
NN |
denotes |
NT |
| T1949 |
2487-2488 |
HYPH |
denotes |
- |
| T1950 |
2488-2489 |
CD |
denotes |
3 |
| T1951 |
2489-2490 |
-RRB- |
denotes |
) |
| T1952 |
2491-2492 |
-LRB- |
denotes |
[ |
| T1953 |
2492-2493 |
CD |
denotes |
9 |
| T1954 |
2493-2494 |
-RRB- |
denotes |
] |
| T1955 |
2494-2495 |
. |
denotes |
. |
| T1956 |
2495-2722 |
sentence |
denotes |
These two ETS proteins control late aspects of spinal monosynaptic circuit assembly, with Er81 directing proprioceptive sensory neuron differentiation and Pea3 directing motor neuron pool differentiation, respectively [14,15]. |
| T1957 |
2496-2501 |
DT |
denotes |
These |
| T1958 |
2510-2518 |
NN |
denotes |
proteins |
| T1959 |
2502-2505 |
CD |
denotes |
two |
| T1960 |
2506-2509 |
NN |
denotes |
ETS |
| T1961 |
2519-2526 |
VBP |
denotes |
control |
| T1962 |
2527-2531 |
JJ |
denotes |
late |
| T1963 |
2532-2539 |
NNS |
denotes |
aspects |
| T1964 |
2540-2542 |
IN |
denotes |
of |
| T1965 |
2543-2549 |
JJ |
denotes |
spinal |
| T1966 |
2563-2570 |
NN |
denotes |
circuit |
| T1967 |
2550-2562 |
JJ |
denotes |
monosynaptic |
| T1968 |
2571-2579 |
NN |
denotes |
assembly |
| T1969 |
2579-2581 |
, |
denotes |
, |
| T1970 |
2581-2585 |
IN |
denotes |
with |
| T1971 |
2586-2590 |
NN |
denotes |
Er81 |
| T1972 |
2591-2600 |
VBG |
denotes |
directing |
| T1973 |
2601-2615 |
JJ |
denotes |
proprioceptive |
| T1974 |
2624-2630 |
NN |
denotes |
neuron |
| T1975 |
2616-2623 |
JJ |
denotes |
sensory |
| T1976 |
2631-2646 |
NN |
denotes |
differentiation |
| T1977 |
2647-2650 |
CC |
denotes |
and |
| T1978 |
2651-2655 |
NN |
denotes |
Pea3 |
| T1979 |
2656-2665 |
VBG |
denotes |
directing |
| T1980 |
2666-2671 |
NN |
denotes |
motor |
| T1981 |
2679-2683 |
NN |
denotes |
pool |
| T1982 |
2672-2678 |
NN |
denotes |
neuron |
| T1983 |
2684-2699 |
NN |
denotes |
differentiation |
| T1984 |
2699-2701 |
, |
denotes |
, |
| T1985 |
2701-2713 |
RB |
denotes |
respectively |
| T1986 |
2714-2715 |
-LRB- |
denotes |
[ |
| T1987 |
2718-2720 |
CD |
denotes |
15 |
| T1988 |
2715-2717 |
CD |
denotes |
14 |
| T1989 |
2717-2718 |
, |
denotes |
, |
| T1990 |
2720-2721 |
-RRB- |
denotes |
] |
| T1991 |
2721-2722 |
. |
denotes |
. |
| T1992 |
2722-2993 |
sentence |
denotes |
In particular, in the absence of Er81, achieved by mutation in the gene or by deprivation of peripheral neurotrophin signaling, group Ia proprioceptive afferents fail to invade the ventral spinal cord and to make effective synaptic connections with motor neurons [9,14]. |
| T1993 |
2723-2725 |
IN |
denotes |
In |
| T1994 |
2885-2889 |
VBP |
denotes |
fail |
| T1995 |
2726-2736 |
JJ |
denotes |
particular |
| T1996 |
2736-2738 |
, |
denotes |
, |
| T1997 |
2738-2740 |
IN |
denotes |
in |
| T1998 |
2741-2744 |
DT |
denotes |
the |
| T1999 |
2745-2752 |
NN |
denotes |
absence |
| T2000 |
2753-2755 |
IN |
denotes |
of |
| T2001 |
2756-2760 |
NN |
denotes |
Er81 |
| T2002 |
2760-2762 |
, |
denotes |
, |
| T2003 |
2762-2770 |
VBN |
denotes |
achieved |
| T2004 |
2771-2773 |
IN |
denotes |
by |
| T2005 |
2774-2782 |
NN |
denotes |
mutation |
| T2006 |
2783-2785 |
IN |
denotes |
in |
| T2007 |
2786-2789 |
DT |
denotes |
the |
| T2008 |
2790-2794 |
NN |
denotes |
gene |
| T2009 |
2795-2797 |
CC |
denotes |
or |
| T2010 |
2798-2800 |
IN |
denotes |
by |
| T2011 |
2801-2812 |
NN |
denotes |
deprivation |
| T2012 |
2813-2815 |
IN |
denotes |
of |
| T2013 |
2816-2826 |
JJ |
denotes |
peripheral |
| T2014 |
2840-2849 |
NN |
denotes |
signaling |
| T2015 |
2827-2839 |
NN |
denotes |
neurotrophin |
| T2016 |
2849-2851 |
, |
denotes |
, |
| T2017 |
2851-2856 |
NN |
denotes |
group |
| T2018 |
2857-2859 |
NN |
denotes |
Ia |
| T2019 |
2875-2884 |
NNS |
denotes |
afferents |
| T2020 |
2860-2874 |
JJ |
denotes |
proprioceptive |
| T2021 |
2890-2892 |
TO |
denotes |
to |
| T2022 |
2893-2899 |
VB |
denotes |
invade |
| T2023 |
2900-2903 |
DT |
denotes |
the |
| T2024 |
2919-2923 |
NN |
denotes |
cord |
| T2025 |
2904-2911 |
JJ |
denotes |
ventral |
| T2026 |
2912-2918 |
JJ |
denotes |
spinal |
| T2027 |
2924-2927 |
CC |
denotes |
and |
| T2028 |
2928-2930 |
TO |
denotes |
to |
| T2029 |
2931-2935 |
VB |
denotes |
make |
| T2030 |
2936-2945 |
JJ |
denotes |
effective |
| T2031 |
2955-2966 |
NNS |
denotes |
connections |
| T2032 |
2946-2954 |
JJ |
denotes |
synaptic |
| T2033 |
2967-2971 |
IN |
denotes |
with |
| T2034 |
2972-2977 |
NN |
denotes |
motor |
| T2035 |
2978-2985 |
NNS |
denotes |
neurons |
| T2036 |
2986-2987 |
-LRB- |
denotes |
[ |
| T2037 |
2989-2991 |
CD |
denotes |
14 |
| T2038 |
2987-2988 |
CD |
denotes |
9 |
| T2039 |
2988-2989 |
, |
denotes |
, |
| T2040 |
2991-2992 |
-RRB- |
denotes |
] |
| T2041 |
2992-2993 |
. |
denotes |
. |
| T2042 |
2993-3202 |
sentence |
denotes |
The involvement of target-derived signals in induction of ETS transcription factor expression raises the question of the necessity for the observed delay in the onset of ETS signaling for neuronal maturation. |
| T2043 |
2994-2997 |
DT |
denotes |
The |
| T2044 |
2998-3009 |
NN |
denotes |
involvement |
| T2045 |
3088-3094 |
VBZ |
denotes |
raises |
| T2046 |
3010-3012 |
IN |
denotes |
of |
| T2047 |
3013-3019 |
NN |
denotes |
target |
| T2048 |
3020-3027 |
VBN |
denotes |
derived |
| T2049 |
3019-3020 |
HYPH |
denotes |
- |
| T2050 |
3028-3035 |
NNS |
denotes |
signals |
| T2051 |
3036-3038 |
IN |
denotes |
in |
| T2052 |
3039-3048 |
NN |
denotes |
induction |
| T2053 |
3049-3051 |
IN |
denotes |
of |
| T2054 |
3052-3055 |
NN |
denotes |
ETS |
| T2055 |
3077-3087 |
NN |
denotes |
expression |
| T2056 |
3056-3069 |
NN |
denotes |
transcription |
| T2057 |
3070-3076 |
NN |
denotes |
factor |
| T2058 |
3095-3098 |
DT |
denotes |
the |
| T2059 |
3099-3107 |
NN |
denotes |
question |
| T2060 |
3108-3110 |
IN |
denotes |
of |
| T2061 |
3111-3114 |
DT |
denotes |
the |
| T2062 |
3115-3124 |
NN |
denotes |
necessity |
| T2063 |
3125-3128 |
IN |
denotes |
for |
| T2064 |
3129-3132 |
DT |
denotes |
the |
| T2065 |
3142-3147 |
NN |
denotes |
delay |
| T2066 |
3133-3141 |
VBN |
denotes |
observed |
| T2067 |
3148-3150 |
IN |
denotes |
in |
| T2068 |
3151-3154 |
DT |
denotes |
the |
| T2069 |
3155-3160 |
NN |
denotes |
onset |
| T2070 |
3161-3163 |
IN |
denotes |
of |
| T2071 |
3164-3167 |
NN |
denotes |
ETS |
| T2072 |
3168-3177 |
NN |
denotes |
signaling |
| T2073 |
3178-3181 |
IN |
denotes |
for |
| T2074 |
3182-3190 |
JJ |
denotes |
neuronal |
| T2075 |
3191-3201 |
NN |
denotes |
maturation |
| T2076 |
3201-3202 |
. |
denotes |
. |
| T2077 |
3202-3337 |
sentence |
denotes |
Would precocious expression of ETS proteins in post-mitotic neurons also direct the appropriate sensory neuron developmental programs? |
| T2078 |
3203-3208 |
MD |
denotes |
Would |
| T2079 |
3276-3282 |
VB |
denotes |
direct |
| T2080 |
3209-3219 |
JJ |
denotes |
precocious |
| T2081 |
3220-3230 |
NN |
denotes |
expression |
| T2082 |
3231-3233 |
IN |
denotes |
of |
| T2083 |
3234-3237 |
NN |
denotes |
ETS |
| T2084 |
3238-3246 |
NN |
denotes |
proteins |
| T2085 |
3247-3249 |
IN |
denotes |
in |
| T2086 |
3250-3262 |
JJ |
denotes |
post-mitotic |
| T2087 |
3263-3270 |
NNS |
denotes |
neurons |
| T2088 |
3271-3275 |
RB |
denotes |
also |
| T2089 |
3283-3286 |
DT |
denotes |
the |
| T2090 |
3328-3336 |
NNS |
denotes |
programs |
| T2091 |
3287-3298 |
JJ |
denotes |
appropriate |
| T2092 |
3299-3306 |
JJ |
denotes |
sensory |
| T2093 |
3307-3313 |
NN |
denotes |
neuron |
| T2094 |
3314-3327 |
JJ |
denotes |
developmental |
| T2095 |
3336-3337 |
. |
denotes |
? |
| T2096 |
3337-3550 |
sentence |
denotes |
In this study, we have used mouse genetics to test this general idea, by investigating whether the precise timing of onset of ETS transcription factor signaling is essential for normal sensory neuron development. |
| T2097 |
3338-3340 |
IN |
denotes |
In |
| T2098 |
3361-3365 |
VBN |
denotes |
used |
| T2099 |
3341-3345 |
DT |
denotes |
this |
| T2100 |
3346-3351 |
NN |
denotes |
study |
| T2101 |
3351-3353 |
, |
denotes |
, |
| T2102 |
3353-3355 |
PRP |
denotes |
we |
| T2103 |
3356-3360 |
VBP |
denotes |
have |
| T2104 |
3366-3371 |
NN |
denotes |
mouse |
| T2105 |
3372-3380 |
NN |
denotes |
genetics |
| T2106 |
3381-3383 |
TO |
denotes |
to |
| T2107 |
3384-3388 |
VB |
denotes |
test |
| T2108 |
3389-3393 |
DT |
denotes |
this |
| T2109 |
3402-3406 |
NN |
denotes |
idea |
| T2110 |
3394-3401 |
JJ |
denotes |
general |
| T2111 |
3406-3408 |
, |
denotes |
, |
| T2112 |
3408-3410 |
IN |
denotes |
by |
| T2113 |
3411-3424 |
VBG |
denotes |
investigating |
| T2114 |
3425-3432 |
IN |
denotes |
whether |
| T2115 |
3499-3501 |
VBZ |
denotes |
is |
| T2116 |
3433-3436 |
DT |
denotes |
the |
| T2117 |
3445-3451 |
NN |
denotes |
timing |
| T2118 |
3437-3444 |
JJ |
denotes |
precise |
| T2119 |
3452-3454 |
IN |
denotes |
of |
| T2120 |
3455-3460 |
NN |
denotes |
onset |
| T2121 |
3461-3463 |
IN |
denotes |
of |
| T2122 |
3464-3467 |
NN |
denotes |
ETS |
| T2123 |
3489-3498 |
NN |
denotes |
signaling |
| T2124 |
3468-3481 |
NN |
denotes |
transcription |
| T2125 |
3482-3488 |
NN |
denotes |
factor |
| T2126 |
3502-3511 |
JJ |
denotes |
essential |
| T2127 |
3512-3515 |
IN |
denotes |
for |
| T2128 |
3516-3522 |
JJ |
denotes |
normal |
| T2129 |
3538-3549 |
NN |
denotes |
development |
| T2130 |
3523-3530 |
JJ |
denotes |
sensory |
| T2131 |
3531-3537 |
NN |
denotes |
neuron |
| T2132 |
3549-3550 |
. |
denotes |
. |
| T2133 |
3550-3675 |
sentence |
denotes |
We have assessed the biological effects of inducing ETS signaling either at the correct developmental time, or precociously. |
| T2134 |
3551-3553 |
PRP |
denotes |
We |
| T2135 |
3559-3567 |
VBN |
denotes |
assessed |
| T2136 |
3554-3558 |
VBP |
denotes |
have |
| T2137 |
3568-3571 |
DT |
denotes |
the |
| T2138 |
3583-3590 |
NNS |
denotes |
effects |
| T2139 |
3572-3582 |
JJ |
denotes |
biological |
| T2140 |
3591-3593 |
IN |
denotes |
of |
| T2141 |
3594-3602 |
VBG |
denotes |
inducing |
| T2142 |
3603-3606 |
NN |
denotes |
ETS |
| T2143 |
3607-3616 |
NN |
denotes |
signaling |
| T2144 |
3617-3623 |
CC |
denotes |
either |
| T2145 |
3624-3626 |
IN |
denotes |
at |
| T2146 |
3627-3630 |
DT |
denotes |
the |
| T2147 |
3653-3657 |
NN |
denotes |
time |
| T2148 |
3631-3638 |
JJ |
denotes |
correct |
| T2149 |
3639-3652 |
JJ |
denotes |
developmental |
| T2150 |
3657-3659 |
, |
denotes |
, |
| T2151 |
3659-3661 |
CC |
denotes |
or |
| T2152 |
3662-3674 |
RB |
denotes |
precociously |
| T2153 |
3674-3675 |
. |
denotes |
. |
| T2154 |
3675-3853 |
sentence |
denotes |
We find that within proprioceptive sensory neurons, the late onset of ETS signaling is essential for the establishment of normal sensory afferent projections in the spinal cord. |
| T2155 |
3676-3678 |
PRP |
denotes |
We |
| T2156 |
3679-3683 |
VBP |
denotes |
find |
| T2157 |
3684-3688 |
IN |
denotes |
that |
| T2158 |
3760-3762 |
VBZ |
denotes |
is |
| T2159 |
3689-3695 |
IN |
denotes |
within |
| T2160 |
3696-3710 |
JJ |
denotes |
proprioceptive |
| T2161 |
3719-3726 |
NNS |
denotes |
neurons |
| T2162 |
3711-3718 |
JJ |
denotes |
sensory |
| T2163 |
3726-3728 |
, |
denotes |
, |
| T2164 |
3728-3731 |
DT |
denotes |
the |
| T2165 |
3737-3742 |
NN |
denotes |
onset |
| T2166 |
3732-3736 |
JJ |
denotes |
late |
| T2167 |
3743-3745 |
IN |
denotes |
of |
| T2168 |
3746-3749 |
NN |
denotes |
ETS |
| T2169 |
3750-3759 |
NN |
denotes |
signaling |
| T2170 |
3763-3772 |
JJ |
denotes |
essential |
| T2171 |
3773-3776 |
IN |
denotes |
for |
| T2172 |
3777-3780 |
DT |
denotes |
the |
| T2173 |
3781-3794 |
NN |
denotes |
establishment |
| T2174 |
3795-3797 |
IN |
denotes |
of |
| T2175 |
3798-3804 |
JJ |
denotes |
normal |
| T2176 |
3822-3833 |
NNS |
denotes |
projections |
| T2177 |
3805-3812 |
JJ |
denotes |
sensory |
| T2178 |
3813-3821 |
JJ |
denotes |
afferent |
| T2179 |
3834-3836 |
IN |
denotes |
in |
| T2180 |
3837-3840 |
DT |
denotes |
the |
| T2181 |
3848-3852 |
NN |
denotes |
cord |
| T2182 |
3841-3847 |
JJ |
denotes |
spinal |
| T2183 |
3852-3853 |
. |
denotes |
. |
| T2184 |
3853-4072 |
sentence |
denotes |
Precocious initiation of ETS signaling in post-mitotic DRG neurons leads to abnormal DRG neuron differentiation characterized by neurotrophin-independent neurite outgrowth and inappropriate profiles of gene expression. |
| T2185 |
3854-3864 |
JJ |
denotes |
Precocious |
| T2186 |
3865-3875 |
NN |
denotes |
initiation |
| T2187 |
3921-3926 |
VBZ |
denotes |
leads |
| T2188 |
3876-3878 |
IN |
denotes |
of |
| T2189 |
3879-3882 |
NN |
denotes |
ETS |
| T2190 |
3883-3892 |
NN |
denotes |
signaling |
| T2191 |
3893-3895 |
IN |
denotes |
in |
| T2192 |
3896-3908 |
JJ |
denotes |
post-mitotic |
| T2193 |
3913-3920 |
NNS |
denotes |
neurons |
| T2194 |
3909-3912 |
NN |
denotes |
DRG |
| T2195 |
3927-3929 |
IN |
denotes |
to |
| T2196 |
3930-3938 |
JJ |
denotes |
abnormal |
| T2197 |
3950-3965 |
NN |
denotes |
differentiation |
| T2198 |
3939-3942 |
NN |
denotes |
DRG |
| T2199 |
3943-3949 |
NN |
denotes |
neuron |
| T2200 |
3966-3979 |
VBN |
denotes |
characterized |
| T2201 |
3980-3982 |
IN |
denotes |
by |
| T2202 |
3983-3995 |
NN |
denotes |
neurotrophin |
| T2203 |
3996-4007 |
JJ |
denotes |
independent |
| T2204 |
3995-3996 |
HYPH |
denotes |
- |
| T2205 |
4016-4025 |
NN |
denotes |
outgrowth |
| T2206 |
4008-4015 |
NN |
denotes |
neurite |
| T2207 |
4026-4029 |
CC |
denotes |
and |
| T2208 |
4030-4043 |
JJ |
denotes |
inappropriate |
| T2209 |
4044-4052 |
NNS |
denotes |
profiles |
| T2210 |
4053-4055 |
IN |
denotes |
of |
| T2211 |
4056-4060 |
NN |
denotes |
gene |
| T2212 |
4061-4071 |
NN |
denotes |
expression |
| T2213 |
4071-4072 |
. |
denotes |
. |
| T2214 |
4072-4342 |
sentence |
denotes |
Our findings reveal that target-triggered inductive signals provide an effective means of ensuring the late onset of expression of transcription factors, and thus an orderly temporal transcriptional sequence that is crucial for neuronal maturation and circuit assembly. |
| T2215 |
4073-4076 |
PRP$ |
denotes |
Our |
| T2216 |
4077-4085 |
NNS |
denotes |
findings |
| T2217 |
4086-4092 |
VBP |
denotes |
reveal |
| T2218 |
4093-4097 |
IN |
denotes |
that |
| T2219 |
4133-4140 |
VBP |
denotes |
provide |
| T2220 |
4098-4104 |
NN |
denotes |
target |
| T2221 |
4105-4114 |
VBN |
denotes |
triggered |
| T2222 |
4104-4105 |
HYPH |
denotes |
- |
| T2223 |
4125-4132 |
NNS |
denotes |
signals |
| T2224 |
4115-4124 |
JJ |
denotes |
inductive |
| T2225 |
4141-4143 |
DT |
denotes |
an |
| T2226 |
4154-4159 |
NNS |
denotes |
means |
| T2227 |
4144-4153 |
JJ |
denotes |
effective |
| T2228 |
4160-4162 |
IN |
denotes |
of |
| T2229 |
4163-4171 |
VBG |
denotes |
ensuring |
| T2230 |
4172-4175 |
DT |
denotes |
the |
| T2231 |
4181-4186 |
NN |
denotes |
onset |
| T2232 |
4176-4180 |
JJ |
denotes |
late |
| T2233 |
4187-4189 |
IN |
denotes |
of |
| T2234 |
4190-4200 |
NN |
denotes |
expression |
| T2235 |
4201-4203 |
IN |
denotes |
of |
| T2236 |
4204-4217 |
NN |
denotes |
transcription |
| T2237 |
4218-4225 |
NNS |
denotes |
factors |
| T2238 |
4225-4227 |
, |
denotes |
, |
| T2239 |
4227-4230 |
CC |
denotes |
and |
| T2240 |
4231-4235 |
RB |
denotes |
thus |
| T2241 |
4272-4280 |
NN |
denotes |
sequence |
| T2242 |
4236-4238 |
DT |
denotes |
an |
| T2243 |
4239-4246 |
JJ |
denotes |
orderly |
| T2244 |
4247-4255 |
JJ |
denotes |
temporal |
| T2245 |
4256-4271 |
JJ |
denotes |
transcriptional |
| T2246 |
4281-4285 |
WDT |
denotes |
that |
| T2247 |
4286-4288 |
VBZ |
denotes |
is |
| T2248 |
4289-4296 |
JJ |
denotes |
crucial |
| T2249 |
4297-4300 |
IN |
denotes |
for |
| T2250 |
4301-4309 |
JJ |
denotes |
neuronal |
| T2251 |
4310-4320 |
NN |
denotes |
maturation |
| T2252 |
4321-4324 |
CC |
denotes |
and |
| T2253 |
4325-4332 |
NN |
denotes |
circuit |
| T2254 |
4333-4341 |
NN |
denotes |
assembly |
| T2255 |
4341-4342 |
. |
denotes |
. |
| R156 |
T1510 |
T1511 |
amod |
Neuronal,differentiation |
| R157 |
T1511 |
T1512 |
nsubj |
differentiation,is |
| R158 |
T1513 |
T1514 |
det |
a,process |
| R159 |
T1514 |
T1512 |
attr |
process,is |
| R160 |
T1515 |
T1514 |
amod |
protracted,process |
| R161 |
T1516 |
T1517 |
prep |
during,express |
| R162 |
T1517 |
T1514 |
relcl |
express,process |
| R163 |
T1518 |
T1516 |
pobj |
which,during |
| R164 |
T1519 |
T1520 |
advmod |
newly,generated |
| R165 |
T1520 |
T1521 |
amod |
generated,neurons |
| R166 |
T1521 |
T1517 |
nsubj |
neurons,express |
| R167 |
T1522 |
T1523 |
amod |
distinct,programs |
| R168 |
T1523 |
T1517 |
dative |
programs,express |
| R169 |
T1524 |
T1523 |
amod |
cellular,programs |
| R170 |
T1525 |
T1524 |
cc |
and,cellular |
| R171 |
T1526 |
T1524 |
conj |
molecular,cellular |
| R172 |
T1527 |
T1517 |
prep |
at,express |
| R173 |
T1528 |
T1529 |
amod |
precise,times |
| R174 |
T1529 |
T1527 |
pobj |
times,at |
| R175 |
T1530 |
T1517 |
prep |
during,express |
| R176 |
T1531 |
T1532 |
poss |
their,maturation |
| R177 |
T1532 |
T1530 |
pobj |
maturation,during |
| R178 |
T1533 |
T1517 |
punct |
: ,express |
| R179 |
T1534 |
T1535 |
amod |
long,distance |
| R180 |
T1535 |
T1537 |
compound |
distance,outgrowth |
| R181 |
T1536 |
T1535 |
punct |
-,distance |
| R182 |
T1537 |
T1517 |
dobj |
outgrowth,express |
| R183 |
T1538 |
T1537 |
compound |
axon,outgrowth |
| R184 |
T1539 |
T1537 |
punct |
", ",outgrowth |
| R185 |
T1540 |
T1541 |
amod |
subsequent,branching |
| R186 |
T1541 |
T1537 |
conj |
branching,outgrowth |
| R187 |
T1542 |
T1541 |
amod |
terminal,branching |
| R188 |
T1543 |
T1541 |
punct |
", ",branching |
| R189 |
T1544 |
T1541 |
cc |
and,branching |
| R190 |
T1545 |
T1546 |
advmod |
finally,synaptogenesis |
| R191 |
T1546 |
T1541 |
conj |
synaptogenesis,branching |
| R192 |
T1547 |
T1512 |
punct |
.,is |
| R193 |
T1549 |
T1550 |
amod |
Many,aspects |
| R194 |
T1550 |
T1552 |
nsubj |
aspects,appear |
| R195 |
T1551 |
T1550 |
amod |
important,aspects |
| R196 |
T1553 |
T1550 |
prep |
of,aspects |
| R197 |
T1554 |
T1555 |
amod |
neuronal,character |
| R198 |
T1555 |
T1553 |
pobj |
character,of |
| R199 |
T1556 |
T1557 |
aux |
to,acquired |
| R200 |
T1557 |
T1552 |
xcomp |
acquired,appear |
| R201 |
T1558 |
T1557 |
auxpass |
be,acquired |
| R202 |
T1559 |
T1557 |
prep |
through,acquired |
| R203 |
T1560 |
T1561 |
det |
the,expression |
| R204 |
T1561 |
T1559 |
pobj |
expression,through |
| R205 |
T1562 |
T1561 |
prep |
of,expression |
| R206 |
T1563 |
T1564 |
compound |
transcription,factors |
| R207 |
T1564 |
T1562 |
pobj |
factors,of |
| R208 |
T1565 |
T1561 |
prep |
at,expression |
| R209 |
T1566 |
T1567 |
compound |
progenitor,stages |
| R210 |
T1567 |
T1565 |
pobj |
stages,at |
| R211 |
T1568 |
T1567 |
compound |
cell,stages |
| R212 |
T1569 |
T1552 |
punct |
", ",appear |
| R213 |
T1570 |
T1571 |
mark |
whereas,depend |
| R214 |
T1571 |
T1552 |
advcl |
depend,appear |
| R215 |
T1572 |
T1571 |
nsubj |
others,depend |
| R216 |
T1573 |
T1571 |
prep |
on,depend |
| R217 |
T1574 |
T1573 |
pobj |
expression,on |
| R218 |
T1575 |
T1576 |
advmod |
immediately,upon |
| R219 |
T1576 |
T1571 |
prep |
upon,depend |
| R220 |
T1577 |
T1578 |
compound |
cell,cycle |
| R221 |
T1578 |
T1579 |
compound |
cycle,exit |
| R222 |
T1579 |
T1576 |
pobj |
exit,upon |
| R223 |
T1580 |
T1581 |
punct |
[,1 |
| R224 |
T1581 |
T1571 |
parataxis |
1,depend |
| R225 |
T1582 |
T1581 |
punct |
],1 |
| R226 |
T1583 |
T1552 |
punct |
.,appear |
| R227 |
T1585 |
T1586 |
cc |
But,has |
| R228 |
T1587 |
T1588 |
mark |
whether,is |
| R229 |
T1588 |
T1586 |
csubj |
is,has |
| R230 |
T1589 |
T1590 |
det |
the,expression |
| R231 |
T1590 |
T1588 |
nsubj |
expression,is |
| R232 |
T1591 |
T1590 |
amod |
orderly,expression |
| R233 |
T1592 |
T1590 |
cc |
and,expression |
| R234 |
T1593 |
T1590 |
conj |
activity,expression |
| R235 |
T1594 |
T1590 |
prep |
of,expression |
| R236 |
T1595 |
T1596 |
amod |
transcriptional,programs |
| R237 |
T1596 |
T1594 |
pobj |
programs,of |
| R238 |
T1597 |
T1590 |
prep |
at,expression |
| R239 |
T1598 |
T1599 |
advmod |
much,later |
| R240 |
T1599 |
T1600 |
amod |
later,stages |
| R241 |
T1600 |
T1597 |
pobj |
stages,at |
| R242 |
T1601 |
T1600 |
amod |
developmental,stages |
| R243 |
T1602 |
T1590 |
punct |
", ",expression |
| R244 |
T1603 |
T1604 |
advmod |
well,after |
| R245 |
T1604 |
T1590 |
prep |
after,expression |
| R246 |
T1605 |
T1606 |
compound |
cell,cycle |
| R247 |
T1606 |
T1607 |
compound |
cycle,exit |
| R248 |
T1607 |
T1604 |
pobj |
exit,after |
| R249 |
T1608 |
T1588 |
punct |
", ",is |
| R250 |
T1609 |
T1610 |
det |
an,step |
| R251 |
T1610 |
T1588 |
attr |
step,is |
| R252 |
T1611 |
T1610 |
amod |
essential,step |
| R253 |
T1612 |
T1610 |
prep |
in,step |
| R254 |
T1613 |
T1614 |
det |
the,progression |
| R255 |
T1614 |
T1612 |
pobj |
progression,in |
| R256 |
T1615 |
T1614 |
prep |
of,progression |
| R257 |
T1616 |
T1617 |
amod |
neuronal,differentiation |
| R258 |
T1617 |
T1615 |
pobj |
differentiation,of |
| R259 |
T1618 |
T1617 |
cc |
and,differentiation |
| R260 |
T1619 |
T1620 |
compound |
circuit,assembly |
| R261 |
T1620 |
T1617 |
conj |
assembly,differentiation |
| R262 |
T1621 |
T1586 |
advmod |
yet,has |
| R263 |
T1622 |
T1623 |
aux |
to,resolved |
| R264 |
T1623 |
T1586 |
xcomp |
resolved,has |
| R265 |
T1624 |
T1623 |
auxpass |
be,resolved |
| R266 |
T1625 |
T1586 |
punct |
.,has |
| R267 |
T1627 |
T1628 |
det |
The,differentiation |
| R268 |
T1628 |
T1629 |
nsubjpass |
differentiation,studied |
| R269 |
T1630 |
T1628 |
prep |
of,differentiation |
| R270 |
T1631 |
T1632 |
amod |
sensory,neurons |
| R271 |
T1632 |
T1630 |
pobj |
neurons,of |
| R272 |
T1633 |
T1628 |
prep |
of,differentiation |
| R273 |
T1634 |
T1635 |
amod |
dorsal,ganglia |
| R274 |
T1635 |
T1633 |
pobj |
ganglia,of |
| R275 |
T1636 |
T1635 |
compound |
root,ganglia |
| R276 |
T1637 |
T1635 |
punct |
(,ganglia |
| R277 |
T1638 |
T1635 |
appos |
DRG,ganglia |
| R278 |
T1639 |
T1629 |
punct |
),studied |
| R279 |
T1640 |
T1629 |
aux |
has,studied |
| R280 |
T1641 |
T1629 |
auxpass |
been,studied |
| R281 |
T1642 |
T1629 |
advmod |
extensively,studied |
| R282 |
T1643 |
T1629 |
prep |
with,studied |
| R283 |
T1644 |
T1643 |
pobj |
respect,with |
| R284 |
T1645 |
T1644 |
prep |
to,respect |
| R285 |
T1646 |
T1647 |
amod |
inductive,events |
| R286 |
T1647 |
T1645 |
pobj |
events,to |
| R287 |
T1648 |
T1649 |
dep |
that,specify |
| R288 |
T1649 |
T1647 |
relcl |
specify,events |
| R289 |
T1650 |
T1651 |
amod |
neuronal,fate |
| R290 |
T1651 |
T1649 |
dobj |
fate,specify |
| R291 |
T1652 |
T1653 |
punct |
[,3 |
| R292 |
T1653 |
T1651 |
parataxis |
3,fate |
| R293 |
T1654 |
T1653 |
nummod |
2,3 |
| R294 |
T1655 |
T1653 |
punct |
",",3 |
| R295 |
T1656 |
T1653 |
punct |
],3 |
| R296 |
T1657 |
T1651 |
punct |
", ",fate |
| R297 |
T1658 |
T1659 |
advmod |
as,as |
| R298 |
T1659 |
T1651 |
cc |
as,fate |
| R299 |
T1660 |
T1659 |
advmod |
well,as |
| R300 |
T1661 |
T1662 |
det |
the,involvement |
| R301 |
T1662 |
T1651 |
conj |
involvement,fate |
| R302 |
T1663 |
T1662 |
prep |
of,involvement |
| R303 |
T1664 |
T1665 |
amod |
late,factors |
| R304 |
T1665 |
T1663 |
pobj |
factors,of |
| R305 |
T1666 |
T1667 |
npadvmod |
target,derived |
| R306 |
T1667 |
T1665 |
amod |
derived,factors |
| R307 |
T1668 |
T1667 |
punct |
-,derived |
| R308 |
T1669 |
T1665 |
amod |
neurotrophic,factors |
| R309 |
T1670 |
T1662 |
prep |
in,involvement |
| R310 |
T1671 |
T1672 |
det |
the,control |
| R311 |
T1672 |
T1670 |
pobj |
control,in |
| R312 |
T1673 |
T1672 |
prep |
of,control |
| R313 |
T1674 |
T1675 |
amod |
neuronal,survival |
| R314 |
T1675 |
T1673 |
pobj |
survival,of |
| R315 |
T1676 |
T1677 |
punct |
[,4 |
| R316 |
T1677 |
T1662 |
parataxis |
4,involvement |
| R317 |
T1678 |
T1677 |
punct |
],4 |
| R318 |
T1679 |
T1629 |
punct |
.,studied |
| R319 |
T1681 |
T1682 |
amod |
Recent,evidence |
| R320 |
T1682 |
T1683 |
nsubj |
evidence,begun |
| R321 |
T1684 |
T1683 |
aux |
has,begun |
| R322 |
T1685 |
T1686 |
aux |
to,emerge |
| R323 |
T1686 |
T1683 |
xcomp |
emerge,begun |
| R324 |
T1687 |
T1688 |
mark |
that,involved |
| R325 |
T1688 |
T1683 |
ccomp |
involved,begun |
| R326 |
T1689 |
T1690 |
npadvmod |
target,derived |
| R327 |
T1690 |
T1692 |
amod |
derived,factors |
| R328 |
T1691 |
T1690 |
punct |
-,derived |
| R329 |
T1692 |
T1688 |
nsubjpass |
factors,involved |
| R330 |
T1693 |
T1688 |
auxpass |
are,involved |
| R331 |
T1694 |
T1688 |
advmod |
also,involved |
| R332 |
T1695 |
T1688 |
prep |
in,involved |
| R333 |
T1696 |
T1695 |
pcomp |
regulating,in |
| R334 |
T1697 |
T1698 |
amod |
later,aspects |
| R335 |
T1698 |
T1696 |
dobj |
aspects,regulating |
| R336 |
T1699 |
T1698 |
prep |
of,aspects |
| R337 |
T1700 |
T1701 |
amod |
neuronal,differentiation |
| R338 |
T1701 |
T1699 |
pobj |
differentiation,of |
| R339 |
T1702 |
T1703 |
punct |
[,7 |
| R340 |
T1703 |
T1683 |
parataxis |
7,begun |
| R341 |
T1704 |
T1703 |
nummod |
5,7 |
| R342 |
T1705 |
T1703 |
punct |
",",7 |
| R343 |
T1706 |
T1703 |
nummod |
6,7 |
| R344 |
T1707 |
T1703 |
punct |
",",7 |
| R345 |
T1708 |
T1703 |
punct |
],7 |
| R346 |
T1709 |
T1683 |
punct |
.,begun |
| R347 |
T1711 |
T1712 |
prep |
In,addressed |
| R348 |
T1713 |
T1711 |
amod |
particular,In |
| R349 |
T1714 |
T1712 |
punct |
", ",addressed |
| R350 |
T1715 |
T1716 |
amod |
genetic,experiments |
| R351 |
T1716 |
T1712 |
nsubj |
experiments,addressed |
| R352 |
T1717 |
T1712 |
aux |
have,addressed |
| R353 |
T1718 |
T1719 |
det |
the,role |
| R354 |
T1719 |
T1712 |
dobj |
role,addressed |
| R355 |
T1720 |
T1721 |
npadvmod |
survival,independent |
| R356 |
T1721 |
T1719 |
amod |
independent,role |
| R357 |
T1722 |
T1721 |
punct |
-,independent |
| R358 |
T1723 |
T1719 |
prep |
of,role |
| R359 |
T1724 |
T1725 |
amod |
neurotrophic,factors |
| R360 |
T1725 |
T1723 |
pobj |
factors,of |
| R361 |
T1726 |
T1719 |
prep |
during,role |
| R362 |
T1727 |
T1726 |
pobj |
development,during |
| R363 |
T1728 |
T1712 |
prep |
by,addressed |
| R364 |
T1729 |
T1728 |
pcomp |
exploiting,by |
| R365 |
T1730 |
T1729 |
dobj |
strains,exploiting |
| R366 |
T1731 |
T1730 |
prep |
of,strains |
| R367 |
T1732 |
T1731 |
pobj |
mice,of |
| R368 |
T1733 |
T1730 |
amod |
defective,strains |
| R369 |
T1734 |
T1735 |
preconj |
both,in |
| R370 |
T1735 |
T1733 |
prep |
in,defective |
| R371 |
T1736 |
T1737 |
compound |
neurotrophin,signaling |
| R372 |
T1737 |
T1735 |
pobj |
signaling,in |
| R373 |
T1738 |
T1735 |
cc |
and,in |
| R374 |
T1739 |
T1735 |
conj |
in,in |
| R375 |
T1740 |
T1741 |
det |
the,function |
| R376 |
T1741 |
T1739 |
pobj |
function,in |
| R377 |
T1742 |
T1741 |
prep |
of,function |
| R378 |
T1743 |
T1744 |
det |
the,Bax |
| R379 |
T1744 |
T1742 |
pobj |
Bax,of |
| R380 |
T1745 |
T1744 |
amod |
proapoptotic,Bax |
| R381 |
T1746 |
T1744 |
compound |
gene,Bax |
| R382 |
T1747 |
T1748 |
punct |
[,9 |
| R383 |
T1748 |
T1729 |
parataxis |
9,exploiting |
| R384 |
T1749 |
T1748 |
nummod |
8,9 |
| R385 |
T1750 |
T1748 |
punct |
",",9 |
| R386 |
T1751 |
T1748 |
punct |
],9 |
| R387 |
T1752 |
T1712 |
punct |
.,addressed |
| R388 |
T1754 |
T1755 |
det |
These,studies |
| R389 |
T1755 |
T1756 |
nsubj |
studies,revealed |
| R390 |
T1863 |
T1864 |
amod |
peptidergic,neurons |
| R391 |
T1864 |
T1862 |
pobj |
neurons,of |
| R392 |
T1865 |
T1861 |
acl |
expressing,subpopulation |
| R393 |
T1866 |
T1865 |
dobj |
Apterous,expressing |
| R394 |
T1867 |
T1866 |
cc |
and,Apterous |
| R395 |
T1757 |
T1756 |
punct |
", ",revealed |
| R396 |
T1868 |
T1866 |
conj |
Squeeze,Apterous |
| R397 |
T1758 |
T1756 |
prep |
for,revealed |
| R398 |
T1869 |
T1870 |
punct |
[,12 |
| R399 |
T1759 |
T1758 |
pobj |
example,for |
| R400 |
T1760 |
T1756 |
punct |
", ",revealed |
| R401 |
T1870 |
T1846 |
parataxis |
12,control |
| R402 |
T1761 |
T1756 |
aux |
have,revealed |
| R403 |
T1762 |
T1763 |
mark |
that,controls |
| R404 |
T1871 |
T1870 |
nummod |
11,12 |
| R405 |
T1763 |
T1756 |
ccomp |
controls,revealed |
| R406 |
T1764 |
T1765 |
compound |
neurotrophin,signaling |
| R407 |
T1872 |
T1870 |
punct |
",",12 |
| R408 |
T1765 |
T1763 |
nsubj |
signaling,controls |
| R409 |
T1766 |
T1767 |
det |
the,acquisition |
| R410 |
T1767 |
T1763 |
dobj |
acquisition,controls |
| R411 |
T1768 |
T1767 |
prep |
of,acquisition |
| R412 |
T1769 |
T1770 |
amod |
peptidergic,traits |
| R413 |
T1770 |
T1768 |
pobj |
traits,of |
| R414 |
T1873 |
T1870 |
punct |
],12 |
| R415 |
T1771 |
T1767 |
prep |
in,acquisition |
| R416 |
T1772 |
T1773 |
amod |
nociceptive,neurons |
| R417 |
T1773 |
T1771 |
pobj |
neurons,in |
| R418 |
T1774 |
T1773 |
compound |
DRG,neurons |
| R419 |
T1874 |
T1846 |
punct |
.,control |
| R420 |
T1775 |
T1767 |
cc |
and,acquisition |
| R421 |
T1776 |
T1777 |
det |
the,control |
| R422 |
T1876 |
T1877 |
prep |
In,shown |
| R423 |
T1777 |
T1767 |
conj |
control,acquisition |
| R424 |
T1778 |
T1777 |
prep |
of,control |
| R425 |
T1779 |
T1780 |
compound |
target,innervation |
| R426 |
T1780 |
T1778 |
pobj |
innervation,of |
| R427 |
T1878 |
T1876 |
pobj |
vertebrates,In |
| R428 |
T1781 |
T1782 |
punct |
[,9 |
| R429 |
T1782 |
T1763 |
parataxis |
9,controls |
| R430 |
T1783 |
T1782 |
nummod |
8,9 |
| R431 |
T1879 |
T1877 |
punct |
", ",shown |
| R432 |
T1784 |
T1782 |
punct |
",",9 |
| R433 |
T1785 |
T1782 |
punct |
],9 |
| R434 |
T1786 |
T1756 |
punct |
.,revealed |
| R435 |
T1880 |
T1881 |
amod |
peripheral,signals |
| R436 |
T1881 |
T1877 |
nsubjpass |
signals,shown |
| R437 |
T1882 |
T1881 |
amod |
neurotrophic,signals |
| R438 |
T1883 |
T1877 |
aux |
have,shown |
| R439 |
T1788 |
T1789 |
det |
The,onset |
| R440 |
T1789 |
T1790 |
nsubjpass |
onset,shown |
| R441 |
T1884 |
T1877 |
auxpass |
been,shown |
| R442 |
T1791 |
T1789 |
prep |
of,onset |
| R443 |
T1792 |
T1793 |
det |
some,programs |
| R444 |
T1885 |
T1886 |
aux |
to,direct |
| R445 |
T1793 |
T1791 |
pobj |
programs,of |
| R446 |
T1794 |
T1793 |
amod |
transcriptional,programs |
| R447 |
T1795 |
T1789 |
prep |
in,onset |
| R448 |
T1886 |
T1877 |
xcomp |
direct,shown |
| R449 |
T1796 |
T1795 |
pobj |
neurons,in |
| R450 |
T1797 |
T1790 |
punct |
", ",shown |
| R451 |
T1887 |
T1888 |
det |
the,onset |
| R452 |
T1798 |
T1790 |
advmod |
however,shown |
| R453 |
T1799 |
T1790 |
punct |
", ",shown |
| R454 |
T1888 |
T1886 |
dobj |
onset,direct |
| R455 |
T1800 |
T1790 |
aux |
has,shown |
| R456 |
T1801 |
T1790 |
advmod |
also,shown |
| R457 |
T1889 |
T1888 |
prep |
of,onset |
| R458 |
T1802 |
T1790 |
auxpass |
been,shown |
| R459 |
T1803 |
T1804 |
aux |
to,occur |
| R460 |
T1804 |
T1790 |
xcomp |
occur,shown |
| R461 |
T1805 |
T1806 |
advmod |
long,exit |
| R462 |
T1806 |
T1804 |
advcl |
exit,occur |
| R463 |
T1890 |
T1889 |
pobj |
expression,of |
| R464 |
T1807 |
T1806 |
mark |
after,exit |
| R465 |
T1808 |
T1806 |
nsubj |
neurons,exit |
| R466 |
T1809 |
T1810 |
det |
the,cycle |
| R467 |
T1810 |
T1806 |
dobj |
cycle,exit |
| R468 |
T1891 |
T1890 |
prep |
of,expression |
| R469 |
T1811 |
T1810 |
compound |
cell,cycle |
| R470 |
T1812 |
T1790 |
punct |
.,shown |
| R471 |
T1892 |
T1893 |
det |
the,factors |
| R472 |
T1814 |
T1815 |
det |
An,principle |
| R473 |
T1893 |
T1891 |
pobj |
factors,of |
| R474 |
T1815 |
T1817 |
nsubj |
principle,is |
| R475 |
T1816 |
T1815 |
amod |
emerging,principle |
| R476 |
T1894 |
T1893 |
compound |
ETS,factors |
| R477 |
T1818 |
T1815 |
prep |
from,principle |
| R478 |
T1819 |
T1818 |
pobj |
work,from |
| R479 |
T1820 |
T1819 |
prep |
in,work |
| R480 |
T1895 |
T1893 |
compound |
transcription,factors |
| R481 |
T1821 |
T1820 |
pobj |
Drosophila,in |
| R482 |
T1822 |
T1821 |
cc |
and,Drosophila |
| R483 |
T1823 |
T1821 |
conj |
vertebrates,Drosophila |
| R484 |
T1896 |
T1893 |
appos |
Er81,factors |
| R485 |
T1824 |
T1825 |
mark |
that,play |
| R486 |
T1825 |
T1817 |
ccomp |
play,is |
| R487 |
T1826 |
T1827 |
npadvmod |
target,derived |
| R488 |
T1897 |
T1896 |
cc |
and,Er81 |
| R489 |
T1827 |
T1829 |
amod |
derived,factors |
| R490 |
T1828 |
T1827 |
punct |
-,derived |
| R491 |
T1829 |
T1825 |
nsubj |
factors,play |
| R492 |
T1898 |
T1896 |
conj |
Pea3,Er81 |
| R493 |
T1830 |
T1831 |
det |
a,role |
| R494 |
T1831 |
T1825 |
dobj |
role,play |
| R495 |
T1899 |
T1886 |
prep |
in,direct |
| R496 |
T1832 |
T1831 |
amod |
crucial,role |
| R497 |
T1833 |
T1825 |
prep |
in,play |
| R498 |
T1900 |
T1901 |
nmod |
DRG,neurons |
| R499 |
T1834 |
T1835 |
det |
the,induction |
| R500 |
T1835 |
T1833 |
pobj |
induction,in |
| R501 |
T1836 |
T1835 |
prep |
of,induction |
| R502 |
T1901 |
T1899 |
pobj |
neurons,in |
| R503 |
T1837 |
T1838 |
det |
these,programs |
| R504 |
T1838 |
T1836 |
pobj |
programs,of |
| R505 |
T1902 |
T1901 |
amod |
sensory,neurons |
| R506 |
T1839 |
T1838 |
amod |
transcriptional,programs |
| R507 |
T1840 |
T1841 |
punct |
[,10 |
| R508 |
T1841 |
T1825 |
parataxis |
10,play |
| R509 |
T1903 |
T1901 |
cc |
and,neurons |
| R510 |
T1842 |
T1841 |
punct |
],10 |
| R511 |
T1843 |
T1817 |
punct |
.,is |
| R512 |
T1845 |
T1846 |
prep |
In,control |
| R513 |
T1904 |
T1905 |
compound |
motor,pools |
| R514 |
T1847 |
T1845 |
pobj |
Drosophila,In |
| R515 |
T1848 |
T1846 |
punct |
", ",control |
| R516 |
T1849 |
T1850 |
amod |
retrograde,signals |
| R518 |
T1850 |
T1846 |
nsubj |
signals,control |
| R519 |
T1851 |
T1850 |
compound |
BMP,signals |
| R520 |
T1852 |
T1850 |
prep |
from,signals |
| R521 |
T1906 |
T1905 |
compound |
neuron,pools |
| R522 |
T1853 |
T1854 |
det |
the,region |
| R523 |
T1907 |
T1908 |
amod |
several,days |
| R524 |
T1854 |
T1852 |
pobj |
region,from |
| R525 |
T1855 |
T1854 |
compound |
target,region |
| R526 |
T1908 |
T1909 |
npadvmod |
days,become |
| R527 |
T1856 |
T1857 |
det |
the,differentiation |
| R528 |
T1857 |
T1846 |
dobj |
differentiation,control |
| R529 |
T1858 |
T1857 |
amod |
terminal,differentiation |
| R530 |
T1909 |
T1886 |
advcl |
become,direct |
| R531 |
T1859 |
T1857 |
prep |
of,differentiation |
| R532 |
T1860 |
T1861 |
det |
a,subpopulation |
| R533 |
T1861 |
T1859 |
pobj |
subpopulation,of |
| R534 |
T1910 |
T1909 |
mark |
after,become |
| R535 |
T1862 |
T1861 |
prep |
of,subpopulation |
| R536 |
T1911 |
T1912 |
det |
these,neurons |
| R537 |
T1912 |
T1909 |
nsubj |
neurons,become |
| R538 |
T1913 |
T1909 |
aux |
have,become |
| R539 |
T1914 |
T1909 |
acomp |
post-mitotic,become |
| R540 |
T1915 |
T1916 |
punct |
[,16 |
| R541 |
T1969 |
T1961 |
punct |
", ",control |
| R542 |
T1970 |
T1961 |
prep |
with,control |
| R543 |
T1916 |
T1877 |
parataxis |
16,shown |
| R544 |
T1971 |
T1972 |
nsubj |
Er81,directing |
| R545 |
T1972 |
T1970 |
pobj |
directing,with |
| R546 |
T1917 |
T1916 |
nummod |
9,16 |
| R547 |
T1973 |
T1974 |
amod |
proprioceptive,neuron |
| R548 |
T1974 |
T1976 |
compound |
neuron,differentiation |
| R549 |
T1975 |
T1974 |
amod |
sensory,neuron |
| R550 |
T1918 |
T1916 |
punct |
",",16 |
| R551 |
T1976 |
T1972 |
dobj |
differentiation,directing |
| R552 |
T1977 |
T1972 |
cc |
and,directing |
| R553 |
T1919 |
T1916 |
nummod |
13,16 |
| R554 |
T1978 |
T1979 |
nsubj |
Pea3,directing |
| R555 |
T1979 |
T1972 |
conj |
directing,directing |
| R556 |
T1920 |
T1916 |
punct |
",",16 |
| R557 |
T1980 |
T1981 |
compound |
motor,pool |
| R558 |
T1981 |
T1983 |
compound |
pool,differentiation |
| R559 |
T1982 |
T1981 |
compound |
neuron,pool |
| R560 |
T1921 |
T1916 |
nummod |
14,16 |
| R561 |
T1983 |
T1979 |
dobj |
differentiation,directing |
| R562 |
T1984 |
T1972 |
punct |
", ",directing |
| R563 |
T1922 |
T1916 |
punct |
",",16 |
| R564 |
T1985 |
T1972 |
advmod |
respectively,directing |
| R565 |
T1986 |
T1987 |
punct |
[,15 |
| R566 |
T1987 |
T1961 |
parataxis |
15,control |
| R567 |
T1988 |
T1987 |
nummod |
14,15 |
| R568 |
T1989 |
T1987 |
punct |
",",15 |
| R569 |
T1990 |
T1987 |
punct |
],15 |
| R570 |
T1923 |
T1916 |
nummod |
15,16 |
| R571 |
T1991 |
T1961 |
punct |
.,control |
| R572 |
T1993 |
T1994 |
prep |
In,fail |
| R573 |
T1924 |
T1916 |
punct |
",",16 |
| R574 |
T1995 |
T1993 |
amod |
particular,In |
| R575 |
T1996 |
T1994 |
punct |
", ",fail |
| R576 |
T1925 |
T1916 |
punct |
],16 |
| R577 |
T1997 |
T1994 |
prep |
in,fail |
| R578 |
T1998 |
T1999 |
det |
the,absence |
| R579 |
T1926 |
T1877 |
punct |
.,shown |
| R580 |
T1999 |
T1997 |
pobj |
absence,in |
| R581 |
T2000 |
T1999 |
prep |
of,absence |
| R582 |
T2001 |
T2000 |
pobj |
Er81,of |
| R583 |
T1928 |
T1929 |
advmod |
Moreover,known |
| R584 |
T2002 |
T1999 |
punct |
", ",absence |
| R585 |
T2003 |
T1999 |
acl |
achieved,absence |
| R586 |
T2004 |
T2003 |
prep |
by,achieved |
| R587 |
T2005 |
T2004 |
pobj |
mutation,by |
| R588 |
T1930 |
T1929 |
punct |
", ",known |
| R589 |
T2006 |
T2005 |
prep |
in,mutation |
| R590 |
T2007 |
T2008 |
det |
the,gene |
| R591 |
T2008 |
T2006 |
pobj |
gene,in |
| R592 |
T2009 |
T2004 |
cc |
or,by |
| R593 |
T1931 |
T1932 |
det |
the,induction |
| R594 |
T2010 |
T2004 |
conj |
by,by |
| R595 |
T2011 |
T2010 |
pobj |
deprivation,by |
| R596 |
T1932 |
T1929 |
nsubjpass |
induction,known |
| R597 |
T2012 |
T2011 |
prep |
of,deprivation |
| R598 |
T2013 |
T2014 |
amod |
peripheral,signaling |
| R599 |
T1933 |
T1932 |
prep |
of,induction |
| R600 |
T2014 |
T2012 |
pobj |
signaling,of |
| R601 |
T2015 |
T2014 |
compound |
neurotrophin,signaling |
| R602 |
T1934 |
T1935 |
compound |
Er81,expression |
| R603 |
T2016 |
T1994 |
punct |
", ",fail |
| R604 |
T2017 |
T2018 |
nmod |
group,Ia |
| R605 |
T2018 |
T2019 |
nmod |
Ia,afferents |
| R606 |
T1935 |
T1933 |
pobj |
expression,of |
| R607 |
T2019 |
T1994 |
nsubj |
afferents,fail |
| R608 |
T2020 |
T2019 |
amod |
proprioceptive,afferents |
| R609 |
T1936 |
T1932 |
prep |
in,induction |
| R610 |
T2021 |
T2022 |
aux |
to,invade |
| R611 |
T2022 |
T1994 |
xcomp |
invade,fail |
| R612 |
T2023 |
T2024 |
det |
the,cord |
| R613 |
T1937 |
T1938 |
amod |
proprioceptive,afferents |
| R614 |
T2024 |
T2022 |
dobj |
cord,invade |
| R615 |
T2025 |
T2024 |
amod |
ventral,cord |
| R616 |
T1938 |
T1936 |
pobj |
afferents,in |
| R617 |
T2026 |
T2024 |
amod |
spinal,cord |
| R618 |
T2027 |
T2022 |
cc |
and,invade |
| R619 |
T2028 |
T2029 |
aux |
to,make |
| R620 |
T2029 |
T2022 |
conj |
make,invade |
| R621 |
T1939 |
T1929 |
auxpass |
is,known |
| R622 |
T1940 |
T1941 |
aux |
to,mediated |
| R623 |
T2030 |
T2031 |
amod |
effective,connections |
| R624 |
T1941 |
T1929 |
xcomp |
mediated,known |
| R625 |
T2031 |
T2029 |
dobj |
connections,make |
| R626 |
T2032 |
T2031 |
amod |
synaptic,connections |
| R627 |
T2033 |
T2031 |
prep |
with,connections |
| R628 |
T1942 |
T1941 |
auxpass |
be,mediated |
| R629 |
T2034 |
T2035 |
compound |
motor,neurons |
| R630 |
T2035 |
T2033 |
pobj |
neurons,with |
| R631 |
T2036 |
T2037 |
punct |
[,14 |
| R632 |
T1943 |
T1941 |
agent |
by,mediated |
| R633 |
T2037 |
T1994 |
parataxis |
14,fail |
| R634 |
T2038 |
T2037 |
nummod |
9,14 |
| R635 |
T1944 |
T1945 |
amod |
peripheral,neurotrophin |
| R636 |
T2039 |
T2037 |
punct |
",",14 |
| R637 |
T2040 |
T2037 |
punct |
],14 |
| R638 |
T1945 |
T1943 |
pobj |
neurotrophin,by |
| R639 |
T2041 |
T1994 |
punct |
.,fail |
| R640 |
T1946 |
T1945 |
nummod |
3,neurotrophin |
| R641 |
T2043 |
T2044 |
det |
The,involvement |
| R642 |
T1947 |
T1945 |
punct |
(,neurotrophin |
| R643 |
T2044 |
T2045 |
nsubj |
involvement,raises |
| R644 |
T1948 |
T1945 |
appos |
NT,neurotrophin |
| R645 |
T2046 |
T2044 |
prep |
of,involvement |
| R646 |
T2047 |
T2048 |
npadvmod |
target,derived |
| R647 |
T2048 |
T2050 |
amod |
derived,signals |
| R648 |
T1949 |
T1948 |
punct |
-,NT |
| R649 |
T2049 |
T2048 |
punct |
-,derived |
| R650 |
T2050 |
T2046 |
pobj |
signals,of |
| R651 |
T1950 |
T1948 |
nummod |
3,NT |
| R652 |
T2051 |
T2044 |
prep |
in,involvement |
| R653 |
T2052 |
T2051 |
pobj |
induction,in |
| R654 |
T2053 |
T2052 |
prep |
of,induction |
| R655 |
T1951 |
T1941 |
punct |
),mediated |
| R656 |
T2054 |
T2055 |
compound |
ETS,expression |
| R657 |
T2055 |
T2053 |
pobj |
expression,of |
| R658 |
T1952 |
T1953 |
punct |
[,9 |
| R659 |
T2056 |
T2055 |
compound |
transcription,expression |
| R660 |
T1953 |
T1941 |
parataxis |
9,mediated |
| R661 |
T2057 |
T2055 |
compound |
factor,expression |
| R662 |
T2058 |
T2059 |
det |
the,question |
| R663 |
T1954 |
T1953 |
punct |
],9 |
| R664 |
T2059 |
T2045 |
dobj |
question,raises |
| R665 |
T1955 |
T1929 |
punct |
.,known |
| R666 |
T2060 |
T2059 |
prep |
of,question |
| R667 |
T2061 |
T2062 |
det |
the,necessity |
| R668 |
T2062 |
T2060 |
pobj |
necessity,of |
| R669 |
T2063 |
T2062 |
prep |
for,necessity |
| R670 |
T2064 |
T2065 |
det |
the,delay |
| R671 |
T2065 |
T2063 |
pobj |
delay,for |
| R672 |
T1957 |
T1958 |
det |
These,proteins |
| R673 |
T2066 |
T2065 |
amod |
observed,delay |
| R674 |
T2067 |
T2065 |
prep |
in,delay |
| R675 |
T2068 |
T2069 |
det |
the,onset |
| R676 |
T2069 |
T2067 |
pobj |
onset,in |
| R677 |
T1958 |
T1961 |
nsubj |
proteins,control |
| R678 |
T2070 |
T2069 |
prep |
of,onset |
| R679 |
T2071 |
T2072 |
compound |
ETS,signaling |
| R680 |
T2072 |
T2070 |
pobj |
signaling,of |
| R681 |
T1959 |
T1958 |
nummod |
two,proteins |
| R682 |
T2073 |
T2072 |
prep |
for,signaling |
| R683 |
T2074 |
T2075 |
amod |
neuronal,maturation |
| R684 |
T1960 |
T1958 |
compound |
ETS,proteins |
| R685 |
T1962 |
T1963 |
amod |
late,aspects |
| R686 |
T1963 |
T1961 |
dobj |
aspects,control |
| R687 |
T1964 |
T1963 |
prep |
of,aspects |
| R688 |
T1965 |
T1966 |
amod |
spinal,circuit |
| R689 |
T2075 |
T2073 |
pobj |
maturation,for |
| R690 |
T1966 |
T1968 |
compound |
circuit,assembly |
| R691 |
T2076 |
T2045 |
punct |
.,raises |
| R692 |
T2078 |
T2079 |
aux |
Would,direct |
| R693 |
T1967 |
T1966 |
amod |
monosynaptic,circuit |
| R694 |
T2080 |
T2081 |
amod |
precocious,expression |
| R695 |
T1968 |
T1964 |
pobj |
assembly,of |
| R696 |
T2081 |
T2079 |
nsubj |
expression,direct |
| R697 |
T2082 |
T2081 |
prep |
of,expression |
| R698 |
T2182 |
T2181 |
amod |
spinal,cord |
| R699 |
T2083 |
T2084 |
compound |
ETS,proteins |
| R700 |
T2084 |
T2082 |
pobj |
proteins,of |
| R701 |
T2085 |
T2081 |
prep |
in,expression |
| R702 |
T2086 |
T2087 |
amod |
post-mitotic,neurons |
| R703 |
T2087 |
T2085 |
pobj |
neurons,in |
| R704 |
T2088 |
T2079 |
advmod |
also,direct |
| R705 |
T2089 |
T2090 |
det |
the,programs |
| R706 |
T2090 |
T2079 |
dobj |
programs,direct |
| R707 |
T2183 |
T2156 |
punct |
.,find |
| R708 |
T2091 |
T2090 |
amod |
appropriate,programs |
| R709 |
T2092 |
T2093 |
amod |
sensory,neuron |
| R710 |
T2185 |
T2186 |
amod |
Precocious,initiation |
| R711 |
T2093 |
T2090 |
nmod |
neuron,programs |
| R712 |
T2094 |
T2090 |
amod |
developmental,programs |
| R713 |
T2095 |
T2079 |
punct |
?,direct |
| R714 |
T2186 |
T2187 |
nsubj |
initiation,leads |
| R715 |
T2097 |
T2098 |
prep |
In,used |
| R716 |
T2188 |
T2186 |
prep |
of,initiation |
| R717 |
T2099 |
T2100 |
det |
this,study |
| R718 |
T2100 |
T2097 |
pobj |
study,In |
| R719 |
T2101 |
T2098 |
punct |
", ",used |
| R720 |
T2102 |
T2098 |
nsubj |
we,used |
| R721 |
T2103 |
T2098 |
aux |
have,used |
| R722 |
T2189 |
T2190 |
compound |
ETS,signaling |
| R723 |
T2104 |
T2105 |
compound |
mouse,genetics |
| R724 |
T2105 |
T2098 |
dobj |
genetics,used |
| R725 |
T2106 |
T2107 |
aux |
to,test |
| R726 |
T2190 |
T2188 |
pobj |
signaling,of |
| R727 |
T2107 |
T2098 |
advcl |
test,used |
| R728 |
T2108 |
T2109 |
det |
this,idea |
| R729 |
T2109 |
T2107 |
dobj |
idea,test |
| R730 |
T2191 |
T2190 |
prep |
in,signaling |
| R731 |
T2110 |
T2109 |
amod |
general,idea |
| R732 |
T2111 |
T2107 |
punct |
", ",test |
| R733 |
T2192 |
T2193 |
amod |
post-mitotic,neurons |
| R734 |
T2112 |
T2107 |
prep |
by,test |
| R735 |
T2113 |
T2112 |
pcomp |
investigating,by |
| R736 |
T2114 |
T2115 |
mark |
whether,is |
| R737 |
T2193 |
T2191 |
pobj |
neurons,in |
| R738 |
T2115 |
T2113 |
ccomp |
is,investigating |
| R739 |
T2116 |
T2117 |
det |
the,timing |
| R740 |
T2117 |
T2115 |
nsubj |
timing,is |
| R741 |
T2194 |
T2193 |
compound |
DRG,neurons |
| R742 |
T2118 |
T2117 |
amod |
precise,timing |
| R743 |
T2119 |
T2117 |
prep |
of,timing |
| R744 |
T2120 |
T2119 |
pobj |
onset,of |
| R745 |
T2195 |
T2187 |
prep |
to,leads |
| R746 |
T2121 |
T2120 |
prep |
of,onset |
| R747 |
T2122 |
T2123 |
compound |
ETS,signaling |
| R748 |
T2196 |
T2197 |
amod |
abnormal,differentiation |
| R749 |
T2123 |
T2121 |
pobj |
signaling,of |
| R750 |
T2124 |
T2125 |
compound |
transcription,factor |
| R751 |
T2125 |
T2123 |
compound |
factor,signaling |
| R752 |
T2197 |
T2195 |
pobj |
differentiation,to |
| R753 |
T2126 |
T2115 |
acomp |
essential,is |
| R754 |
T2127 |
T2126 |
prep |
for,essential |
| R755 |
T2198 |
T2197 |
compound |
DRG,differentiation |
| R756 |
T2199 |
T2197 |
compound |
neuron,differentiation |
| R757 |
T2128 |
T2129 |
amod |
normal,development |
| R758 |
T2129 |
T2127 |
pobj |
development,for |
| R759 |
T2200 |
T2197 |
acl |
characterized,differentiation |
| R760 |
T2130 |
T2131 |
amod |
sensory,neuron |
| R761 |
T2131 |
T2129 |
compound |
neuron,development |
| R762 |
T2201 |
T2200 |
agent |
by,characterized |
| R763 |
T2132 |
T2098 |
punct |
.,used |
| R764 |
T2134 |
T2135 |
nsubj |
We,assessed |
| R765 |
T2202 |
T2203 |
npadvmod |
neurotrophin,independent |
| R766 |
T2136 |
T2135 |
aux |
have,assessed |
| R767 |
T2203 |
T2205 |
amod |
independent,outgrowth |
| R768 |
T2137 |
T2138 |
det |
the,effects |
| R769 |
T2138 |
T2135 |
dobj |
effects,assessed |
| R770 |
T2204 |
T2203 |
punct |
-,independent |
| R771 |
T2139 |
T2138 |
amod |
biological,effects |
| R772 |
T2140 |
T2138 |
prep |
of,effects |
| R773 |
T2141 |
T2140 |
pcomp |
inducing,of |
| R774 |
T2142 |
T2143 |
compound |
ETS,signaling |
| R775 |
T2143 |
T2141 |
dobj |
signaling,inducing |
| R776 |
T2205 |
T2201 |
pobj |
outgrowth,by |
| R777 |
T2144 |
T2145 |
preconj |
either,at |
| R778 |
T2206 |
T2205 |
compound |
neurite,outgrowth |
| R779 |
T2145 |
T2141 |
prep |
at,inducing |
| R780 |
T2146 |
T2147 |
det |
the,time |
| R781 |
T2147 |
T2145 |
pobj |
time,at |
| R782 |
T2207 |
T2205 |
cc |
and,outgrowth |
| R783 |
T2148 |
T2147 |
amod |
correct,time |
| R784 |
T2149 |
T2147 |
amod |
developmental,time |
| R785 |
T2150 |
T2145 |
punct |
", ",at |
| R786 |
T2208 |
T2209 |
amod |
inappropriate,profiles |
| R787 |
T2151 |
T2145 |
cc |
or,at |
| R788 |
T2152 |
T2145 |
conj |
precociously,at |
| R789 |
T2153 |
T2135 |
punct |
.,assessed |
| R790 |
T2209 |
T2205 |
conj |
profiles,outgrowth |
| R791 |
T2155 |
T2156 |
nsubj |
We,find |
| R792 |
T2210 |
T2209 |
prep |
of,profiles |
| R793 |
T2157 |
T2158 |
mark |
that,is |
| R794 |
T2158 |
T2156 |
ccomp |
is,find |
| R795 |
T2211 |
T2212 |
compound |
gene,expression |
| R796 |
T2159 |
T2158 |
prep |
within,is |
| R797 |
T2160 |
T2161 |
amod |
proprioceptive,neurons |
| R798 |
T2161 |
T2159 |
pobj |
neurons,within |
| R799 |
T2212 |
T2210 |
pobj |
expression,of |
| R800 |
T2162 |
T2161 |
amod |
sensory,neurons |
| R801 |
T2163 |
T2158 |
punct |
", ",is |
| R802 |
T2164 |
T2165 |
det |
the,onset |
| R803 |
T2213 |
T2187 |
punct |
.,leads |
| R804 |
T2165 |
T2158 |
nsubj |
onset,is |
| R805 |
T2166 |
T2165 |
amod |
late,onset |
| R806 |
T2215 |
T2216 |
poss |
Our,findings |
| R807 |
T2167 |
T2165 |
prep |
of,onset |
| R808 |
T2168 |
T2169 |
compound |
ETS,signaling |
| R809 |
T2169 |
T2167 |
pobj |
signaling,of |
| R810 |
T2170 |
T2158 |
acomp |
essential,is |
| R811 |
T2171 |
T2170 |
prep |
for,essential |
| R812 |
T2172 |
T2173 |
det |
the,establishment |
| R813 |
T2173 |
T2171 |
pobj |
establishment,for |
| R814 |
T2216 |
T2217 |
nsubj |
findings,reveal |
| R815 |
T2174 |
T2173 |
prep |
of,establishment |
| R816 |
T2175 |
T2176 |
amod |
normal,projections |
| R817 |
T2176 |
T2174 |
pobj |
projections,of |
| R818 |
T2218 |
T2219 |
mark |
that,provide |
| R819 |
T2177 |
T2178 |
amod |
sensory,afferent |
| R820 |
T2178 |
T2176 |
nmod |
afferent,projections |
| R821 |
T2179 |
T2173 |
prep |
in,establishment |
| R822 |
T2180 |
T2181 |
det |
the,cord |
| R823 |
T2219 |
T2217 |
ccomp |
provide,reveal |
| R824 |
T2181 |
T2179 |
pobj |
cord,in |
| R825 |
T2220 |
T2221 |
npadvmod |
target,triggered |
| R826 |
T2221 |
T2223 |
amod |
triggered,signals |
| R827 |
T2222 |
T2221 |
punct |
-,triggered |
| R828 |
T2223 |
T2219 |
nsubj |
signals,provide |
| R829 |
T2224 |
T2223 |
amod |
inductive,signals |
| R830 |
T2225 |
T2226 |
det |
an,means |
| R831 |
T2226 |
T2219 |
dobj |
means,provide |
| R832 |
T2227 |
T2226 |
amod |
effective,means |
| R833 |
T2228 |
T2226 |
prep |
of,means |
| R834 |
T2229 |
T2228 |
pcomp |
ensuring,of |
| R835 |
T2230 |
T2231 |
det |
the,onset |
| R836 |
T2231 |
T2229 |
dobj |
onset,ensuring |
| R837 |
T2232 |
T2231 |
amod |
late,onset |
| R838 |
T2233 |
T2231 |
prep |
of,onset |
| R839 |
T2234 |
T2233 |
pobj |
expression,of |
| R840 |
T2235 |
T2234 |
prep |
of,expression |
| R841 |
T2236 |
T2237 |
compound |
transcription,factors |
| R842 |
T2237 |
T2235 |
pobj |
factors,of |
| R843 |
T2238 |
T2219 |
punct |
", ",provide |
| R844 |
T2239 |
T2219 |
cc |
and,provide |
| R845 |
T2240 |
T2241 |
advmod |
thus,sequence |
| R846 |
T2241 |
T2219 |
conj |
sequence,provide |
| R847 |
T2242 |
T2241 |
det |
an,sequence |
| R848 |
T2243 |
T2241 |
amod |
orderly,sequence |
| R849 |
T2244 |
T2241 |
amod |
temporal,sequence |
| R850 |
T2245 |
T2241 |
amod |
transcriptional,sequence |
| R851 |
T2246 |
T2247 |
dep |
that,is |
| R852 |
T2247 |
T2241 |
relcl |
is,sequence |
| R853 |
T2248 |
T2247 |
acomp |
crucial,is |
| R854 |
T2249 |
T2248 |
prep |
for,crucial |
| R855 |
T2250 |
T2251 |
amod |
neuronal,maturation |
| R856 |
T2251 |
T2249 |
pobj |
maturation,for |
| R857 |
T2252 |
T2251 |
cc |
and,maturation |
| R858 |
T2253 |
T2254 |
compound |
circuit,assembly |
| R859 |
T2254 |
T2251 |
conj |
assembly,maturation |
| R860 |
T2255 |
T2217 |
punct |
.,reveal |
| R517 |
T1905 |
T1901 |
conj |
pools,neurons |