PMC:1084331 / 12156-13156 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1084331","sourcedb":"PMC","sourceid":"1084331","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1084331","text":"Rescue of Ia Proprioceptive Afferent Projections into the Ventral Spinal Cord in Er81EWS-Pea3 Mutants\n(A–F) Morphological analysis of central projections at lumbar level L3 of PV+ DRG neurons (A–C) or all DRG sensory afferents after application of fluorescently labeled dextran to individual dorsal roots (D–F) in P0.5 (A–C) or P5 (D–F) wild-type (A and D), Er81−/− (B and E), and Er81EWS-Pea3/− (C and F) mice. Red dotted line indicates intermediate level of spinal cord.\n(G–I) Analysis of vGlut1 immunocytochemistry in the ventral horn of P0.5 wild-type (G), Er81−/− (H), and Er81EWS-Pea3/− (I) mice. Yellow dotted box in (A) indicates size of images shown in (G–I).\n(J–L) Schematic summary diagrams of the morphological rescue of Ia proprioceptive afferent projections (blue) into the ventral spinal cord observed in wild-type (J), Er81−/− (K), and Er81EWS-Pea3/− (L) mice. DRG indicated by dotted grey line; motor neurons are shown in black.\nScale bar: (A–C), 150 μm; (D–F), 160 μm; (G–I), 70 μm.","divisions":[{"label":"title","span":{"begin":0,"end":101}},{"label":"p","span":{"begin":102,"end":472}},{"label":"p","span":{"begin":473,"end":668}},{"label":"p","span":{"begin":669,"end":945}}],"tracks":[]}