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Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling\nETS Transcription Factor Signaling in DRG Neurons\n\nAbstract\nTwo ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.\n\nBy expressing ETS transcription factors at different developmental stages of dorsal root ganglion development, the authors show that late onset of ETS expression is essential for normal sensory neuron differentiation\n\nIntroduction\nNeuronal differentiation is a protracted process during which newly generated neurons express distinct cellular and molecular programs at precise times during their maturation: long-distance axon outgrowth, subsequent terminal branching, and finally synaptogenesis. Many important aspects of neuronal character appear to be acquired through the expression of transcription factors at progenitor cell stages, whereas others depend on expression immediately upon cell cycle exit [1]. But whether the orderly expression and activity of transcriptional programs at much later developmental stages, well after cell cycle exit, is an essential step in the progression of neuronal differentiation and circuit assembly has yet to be resolved.\nThe differentiation of"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T187","span":{"begin":42,"end":45},"obj":"UBERON:0000044"},{"id":"T188","span":{"begin":46,"end":53},"obj":"CL:0000540"},{"id":"T189","span":{"begin":189,"end":193},"obj":"PR:000007227"},{"id":"T190","span":{"begin":237,"end":257},"obj":"UBERON:0000044"},{"id":"T191","span":{"begin":237,"end":257},"obj":"_FRAGMENT"},{"id":"T192","span":{"begin":264,"end":271},"obj":"_FRAGMENT"},{"id":"T193","span":{"begin":289,"end":296},"obj":"CL:1001451"},{"id":"T194","span":{"begin":259,"end":262},"obj":"UBERON:0000044"},{"id":"T195","span":{"begin":259,"end":262},"obj":"_FRAGMENT"},{"id":"T196","span":{"begin":276,"end":282},"obj":"UBERON:0001130"},{"id":"T197","span":{"begin":276,"end":296},"obj":"CL:0011001"},{"id":"T198","span":{"begin":330,"end":340},"obj":"GO:0010467"},{"id":"T199","span":{"begin":341,"end":349},"obj":"GO:0065007"},{"id":"T200","span":{"begin":366,"end":374},"obj":"CL:0000540"},{"id":"T201","span":{"begin":471,"end":475},"obj":"SO:0000704"},{"id":"T202","span":{"begin":471,"end":486},"obj":"GO:0010467"},{"id":"T203","span":{"begin":526,"end":540},"obj":"CL:0000101"},{"id":"T204","span":{"begin":569,"end":576},"obj":"SO:0000704"},{"id":"T205","span":{"begin":593,"end":598},"obj":"NCBITaxon:10088"},{"id":"T206","span":{"begin":619,"end":629},"obj":"GO:0010467"},{"id":"T207","span":{"begin":633,"end":636},"obj":"UBERON:0000044"},{"id":"T208","span":{"begin":633,"end":652},"obj":"CL:1001451"},{"id":"T209","span":{"begin":662,"end":680},"obj":"GO:0030424"},{"id":"T210","span":{"begin":818,"end":821},"obj":"UBERON:0000044"},{"id":"T211","span":{"begin":818,"end":837},"obj":"CL:1001451"},{"id":"T212","span":{"begin":982,"end":990},"obj":"CL:0000540"},{"id":"T213","span":{"begin":982,"end":1001},"obj":"GO:0042551"},{"id":"T1230","span":{"begin":1235,"end":1243},"obj":"CL:0000540"},{"id":"T1231","span":{"begin":1313,"end":1320},"obj":"CL:0000540"},{"id":"T1232","span":{"begin":1321,"end":1328},"obj":"GO:0010467"},{"id":"T1233","span":{"begin":1412,"end":1440},"obj":"GO:0007409"},{"id":"T1234","span":{"begin":1426,"end":1430},"obj":"GO:0030424"},{"id":"T1235","span":{"begin":1485,"end":1499},"obj":"GO:0007416"},{"id":"T1236","span":{"begin":1527,"end":1535},"obj":"CL:0000540"},{"id":"T1237","span":{"begin":1580,"end":1590},"obj":"GO:0010467"},{"id":"T1238","span":{"begin":1668,"end":1678},"obj":"GO:0010467"},{"id":"T1239","span":{"begin":1696,"end":1706},"obj":"GO:0007049"},{"id":"T1240","span":{"begin":1741,"end":1751},"obj":"GO:0010467"},{"id":"T1241","span":{"begin":1840,"end":1850},"obj":"GO:0007049"},{"id":"T1242","span":{"begin":1900,"end":1908},"obj":"CL:0000540"},{"id":"T1243","span":{"begin":1900,"end":1908},"obj":"_FRAGMENT"},{"id":"T1244","span":{"begin":1929,"end":1936},"obj":"UBERON:0024914"}],"relations":[{"id":"R2","pred":"_lexicallyChainedTo","subj":"T192","obj":"T195"},{"id":"R3","pred":"_lexicallyChainedTo","subj":"T193","obj":"T192"},{"id":"R148","pred":"_lexicallyChainedTo","subj":"T1244","obj":"T1243"},{"id":"R1","pred":"_lexicallyChainedTo","subj":"T192","obj":"T191"}],"text":"A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling\nETS Transcription Factor Signaling in DRG Neurons\n\nAbstract\nTwo ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.\n\nBy expressing ETS transcription factors at different developmental stages of dorsal root ganglion development, the authors show that late onset of ETS expression is essential for normal sensory neuron differentiation\n\nIntroduction\nNeuronal differentiation is a protracted process during which newly generated neurons express distinct cellular and molecular programs at precise times during their maturation: long-distance axon outgrowth, subsequent terminal branching, and finally synaptogenesis. Many important aspects of neuronal character appear to be acquired through the expression of transcription factors at progenitor cell stages, whereas others depend on expression immediately upon cell cycle exit [1]. But whether the orderly expression and activity of transcriptional programs at much later developmental stages, well after cell cycle exit, is an essential step in the progression of neuronal differentiation and circuit assembly has yet to be resolved.\nThe differentiation of"}