PMC:1079843 / 17221-18017 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1079843","sourcedb":"PMC","sourceid":"1079843","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1079843","text":"Detection of TPH1 gene polymorphisms in the Taiwanese Han population\nTo detect SNPs in the human TPH1 gene, we used the enzymatic cleavage approach to screen all 11 exons, parts of neighboring introns, and the promoter of the gene in 30 unrelated healthy and 20 BPD probands from a previously recruited population [31]. No sequence variation in the coding region of the TPH1 gene was identified. However, screening for nucleotide variants up to -1,151 bases in the promoter region and down to 1,572 bases in the 3'UTR identified five SNPs. Two, A-1067G (5'flankingSNP2) and G-347T (5'flankingSNP3), were found in the promoter region. Of the remaining 3 SNPs, T3804A (in1SNP1) was located in intron 1/exon 1c, while C27224T (3'UTRSNP1) and A27237G (3'UTRSNP2) were located in the 3'UTR of exon 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