PMC:1079843 / 15893-17210 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1079843","sourcedb":"PMC","sourceid":"1079843","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1079843","text":"Statistical analysis\nThe chi-squared test for allelic and genotypic distributions between patients and controls was performed using the CROSSTAB program implemented by SPSS. The Hardy-Weinberg equilibrium was analyzed using the HWE program, version 2.33 [37]. Pairwise LD coefficients D' [38] among the 10 SNPs were estimated and statistical significances were determined by using the SNP Alyze® program (SNP and Disease Association Analysis software; Dynacom Co., Ltd. Kanagawa, Japan). In addition, the PHASE 2.0 program [39,40] was used to construct haplotypes and perform a case-control permutation test, then the Fisher's exact test was applied to test differences in haplotype frequencies between cases and controls. All Fisher's exact tests (two tails) and estimation of the odds ratio of BPD associated with a particular haplotype were performed using the PROC FREQ program implemented by SAS package (SAS Institute Inc., Cary, NC, USA). Haplotype-tag SNPs were selected using SNPtagger software [41]. To consider the multiple comparisons, a Bonferroni correction was applied in this study thus the p value for reaching significance is 0.005 for 10 SNPs. 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