PMC:1069006 / 9149-10980
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/1069006","sourcedb":"PMC","sourceid":"1069006","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1069006","text":"Genome comparison\nThe overall comparison of S.Choleraesuis SC-B67 genome to two other sequenced Salmonella genomes is shown in Table 1 (9,10). The S.Choleraesuis SC-B67 chromosome is 101 732 bp shorter than S.Typhimurium LT2, and 53 337 bp shorter than S.Typhi CT18; however, S.Typhi CT18 genome contains a unique 134 kb DNA segment coding for Vi capsule (9,10). The overall similarity of SC-B67 genome to those of LT2 and CT18 (see Supplementary Figure S1) is demonstrated by CROSS_MATCH comparison of the genomes (P. Green, unpublished data) with NUCmer (24). They are generally collinear and share \u003e98% homology at the DNA level; however, such co-linearity between SC-B67 and CT18 is in part broken by two major inverted segments. Rearrangements between the rrn operons are common in S.Typhi (25), but are not found in S.Typhimurium LT2 and S.Choleraesuis SC-B67. A comparison of the insertions and deletions (indels) among the three sequenced serovars indicates that such events generally involve a small number of genes (Figure 2). The three Salmonella genomes are similar in size, indicating that the acquisition of genes has been counterbalanced by deletions; however, more deletion events occurred in S.Choleraesuis and S.Typhi (Figure 2). There are three major differences between S.Typhi and the two non-typhoidal Salmonella. S.Typhi contains Vi capsule, many more deletions, and a different profile of adherence- and motility-related genes, for which it lacks sti, stf, lpf, pef and fljA, but harbors genes like sta, stg, sef and pil. Vi is important in the pathogenesis of typhoid fever because of its role in antiphagocytosis and complement evasion. It is, however, difficult to address the relatedness between the different fimbrial patterns and pathogenicity, due to the redundancy of fimbrial operons in Salmonella.","divisions":[{"label":"Title","span":{"begin":0,"end":17}}],"tracks":[{"project":"2_test","denotations":[{"id":"15781495-11677609-76989439","span":{"begin":136,"end":137},"obj":"11677609"},{"id":"15781495-11677608-76989440","span":{"begin":138,"end":140},"obj":"11677608"},{"id":"15781495-11677609-76989441","span":{"begin":356,"end":357},"obj":"11677609"},{"id":"15781495-11677608-76989442","span":{"begin":358,"end":360},"obj":"11677608"},{"id":"15781495-12034836-76989443","span":{"begin":557,"end":559},"obj":"12034836"},{"id":"15781495-8816795-76989444","span":{"begin":796,"end":798},"obj":"8816795"}],"attributes":[{"subj":"15781495-11677609-76989439","pred":"source","obj":"2_test"},{"subj":"15781495-11677608-76989440","pred":"source","obj":"2_test"},{"subj":"15781495-11677609-76989441","pred":"source","obj":"2_test"},{"subj":"15781495-11677608-76989442","pred":"source","obj":"2_test"},{"subj":"15781495-12034836-76989443","pred":"source","obj":"2_test"},{"subj":"15781495-8816795-76989444","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#cdec93","default":true}]}]}}