PMC:1069006 / 15219-16034 JSONTXT

{"project":"2_test","denotations":[{"id":"15781495-10830113-76989458","span":{"begin":266,"end":268},"obj":"10830113"}],"text":"von Willebrand factor\nThe genome of S.Choleraesuis encodes a protein bearing homology to von Willebrand factor type A domain of humans (SC2319, vwa). The von Willebrand factor is a multimeric glycoprotein that is synthesized in megakaryocytes and endothelial cells (30). During normal hemostasis, it adheres to the subendothelial matrix following vascular damage. This vwa gene was also found in S.Typhimurium, but not in S.Typhi. Because a gene (SC1603) encoding microbial collagenase has been identified, it is reasonable to propose that collagenase-mediated vascular injury during infection and subsequent combined effect of the Vwa could lead to the development of septic vascular thrombi. This may explain the observed severe vascular sequelae of non-typhoidal Salmonella infections, namely infective aneurysm."}