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We have also shown that upregulation of IL-17 by activated T cells in patients with RA could be the result of activation via the PI3K/Akt pathway with resultant NF-κB activation. Our data provide insights into cellular mechanisms of the regulation of IL-17 production in RA, and highlight the role of T cells, which has hitherto been neglected in RA pathogenesis. Together with recent data on the successful introduction of anti-IL-17 in RA, our results have added information for the future molecular targeting of new therapeutic applications in RA."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T22349","span":{"begin":574,"end":579},"obj":"Protein"},{"id":"T22348","span":{"begin":396,"end":401},"obj":"Protein"},{"id":"T22347","span":{"begin":279,"end":282},"obj":"Protein"},{"id":"T22346","span":{"begin":185,"end":190},"obj":"Protein"},{"id":"T22345","span":{"begin":139,"end":143},"obj":"Protein"},{"id":"T22344","span":{"begin":93,"end":98},"obj":"Protein"},{"id":"T22343","span":{"begin":83,"end":88},"obj":"Protein"},{"id":"T22342","span":{"begin":49,"end":54},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation by anti-CD3/anti-CD28. We have also shown that upregulation of IL-17 by activated T cells in patients with RA could be the result of activation via the PI3K/Akt pathway with resultant NF-κB activation. Our data provide insights into cellular mechanisms of the regulation of IL-17 production in RA, and highlight the role of T cells, which has hitherto been neglected in RA pathogenesis. Together with recent data on the successful introduction of anti-IL-17 in RA, our results have added information for the future molecular targeting of new therapeutic applications in RA."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T22402","span":{"begin":139,"end":143},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T22401","span":{"begin":130,"end":133},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T22400","span":{"begin":130,"end":133},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T22399","span":{"begin":130,"end":133},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T22398","span":{"begin":130,"end":133},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T22397","span":{"begin":83,"end":88},"obj":"http://www.uniprot.org/uniprot/P40933"},{"id":"T22396","span":{"begin":574,"end":579},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T22395","span":{"begin":396,"end":401},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T22394","span":{"begin":185,"end":190},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T22393","span":{"begin":49,"end":54},"obj":"http://www.uniprot.org/uniprot/Q16552"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation by anti-CD3/anti-CD28. We have also shown that upregulation of IL-17 by activated T cells in patients with RA could be the result of activation via the PI3K/Akt pathway with resultant NF-κB activation. Our data provide insights into cellular mechanisms of the regulation of IL-17 production in RA, and highlight the role of T cells, which has hitherto been neglected in RA pathogenesis. Together with recent data on the successful introduction of anti-IL-17 in RA, our results have added information for the future molecular targeting of new therapeutic applications in RA."}

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