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PMC:1064895 / 26703-28087 JSONTXT

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test3

Id Subject Object Predicate Lexical cue
T17221 1293-1298 Protein denotes IL-17
T17220 1212-1217 Protein denotes IL-17
T17219 1105-1113 Entity denotes promoter
T17218 1099-1104 Protein denotes IL-17
T17217 1075-1082 Binding denotes binding
T17216 991-996 Protein denotes IL-17
T17215 975-987 Positive_regulation denotes upregulation
T17214 900-903 Protein denotes Akt
T17213 851-858 Negative_regulation denotes lacking
T17212 841-846 Protein denotes IL-17
T17211 832-840 Positive_regulation denotes inducing
T17210 717-728 Binding denotes association
T17209 710-713 Protein denotes Akt
T17208 519-523 Protein denotes AP-1
T17207 484-489 Protein denotes IL-17
T17206 471-480 Positive_regulation denotes induction
T17205 359-364 Protein denotes IL-15
T17204 353-357 Protein denotes CD28
T17203 326-335 Positive_regulation denotes activated
T17202 273-278 Protein denotes IL-17
T17201 260-269 Positive_regulation denotes induction
T17200 170-184 Phosphorylation denotes phosphorylated
T17199 163-166 Protein denotes Akt
T17198 120-124 Negative_regulation denotes loss
T17197 85-95 Positive_regulation denotes activation
T17196 81-84 Protein denotes Akt
T17095 1293-1298 Protein denotes IL-17
T17094 1212-1217 Protein denotes IL-17
T17093 1099-1104 Protein denotes IL-17
T17092 991-996 Protein denotes IL-17
T17091 900-903 Protein denotes Akt
T17090 841-846 Protein denotes IL-17
T17089 710-713 Protein denotes Akt
T17088 519-523 Protein denotes AP-1
T17087 484-489 Protein denotes IL-17
T17086 359-364 Protein denotes IL-15
T17085 353-357 Protein denotes CD28
T17084 273-278 Protein denotes IL-17
T17083 163-166 Protein denotes Akt
T17082 81-84 Protein denotes Akt
R9318 T17196 T17197 themeOf Akt,activation
R9319 T17199 T17200 themeOf Akt,phosphorylated
R9320 T17202 T17201 themeOf IL-17,induction
R9321 T17207 T17206 themeOf IL-17,induction
R9322 T17209 T17210 themeOf Akt,association
R9323 T17212 T17213 themeOf IL-17,lacking
R9324 T17216 T17215 themeOf IL-17,upregulation
R9325 T17219 T17218 partOf promoter,IL-17
R9326 T17219 T17217 themeOf promoter,binding

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T20163 1194-1203 Positive_regulation denotes induction
T20162 975-987 Positive_regulation denotes upregulation
T20161 717-728 Binding denotes association
T20160 851-858 Negative_regulation denotes lacking
T20159 471-480 Positive_regulation denotes induction
T20158 455-463 Regulation denotes involved
T20157 170-184 Phosphorylation denotes phosphorylated
T20156 260-269 Positive_regulation denotes induction
T20155 233-244 Regulation denotes involvement
T20154 85-95 Positive_regulation denotes activation
T20153 69-77 Regulation denotes response
T20108 1293-1298 Protein denotes IL-17
T20107 1212-1217 Protein denotes IL-17
T20106 1099-1104 Protein denotes IL-17
T20105 991-996 Protein denotes IL-17
T20104 900-903 Protein denotes Akt
T20103 841-846 Protein denotes IL-17
T20102 710-713 Protein denotes Akt
T20101 519-523 Protein denotes AP-1
T20100 484-489 Protein denotes IL-17
T20099 359-364 Protein denotes IL-15
T20098 353-357 Protein denotes CD28
T20097 273-278 Protein denotes IL-17
T20096 163-166 Protein denotes Akt
T20095 81-84 Protein denotes Akt
R10630 T20095 T20154 themeOf Akt,activation
R10631 T20096 T20157 themeOf Akt,phosphorylated
R10632 T20097 T20156 themeOf IL-17,induction
R10633 T20100 T20159 themeOf IL-17,induction
R10634 T20102 T20161 themeOf Akt,association
R10635 T20103 T20160 themeOf IL-17,lacking
R10636 T20105 T20162 themeOf IL-17,upregulation
R10637 T20107 T20163 themeOf IL-17,induction
R10660 T20154 T20153 themeOf activation,response
R10661 T20156 T20155 themeOf induction,involvement
R10662 T20159 T20158 themeOf induction,involved

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T21980 1194-1203 Positive_regulation denotes induction
T21979 975-987 Positive_regulation denotes upregulation
T21978 1057-1065 Negative_regulation denotes blocking
T21977 851-858 Negative_regulation denotes lacking
T21976 471-480 Positive_regulation denotes induction
T21975 170-184 Phosphorylation denotes phosphorylated
T21974 233-244 Regulation denotes involvement
T21973 260-269 Positive_regulation denotes induction
T21972 85-95 Positive_regulation denotes activation
T21932 1293-1298 Protein denotes IL-17
T21931 1212-1217 Protein denotes IL-17
T21930 1099-1104 Protein denotes IL-17
T21929 991-996 Protein denotes IL-17
T21928 900-903 Protein denotes Akt
T21927 841-846 Protein denotes IL-17
T21926 710-713 Protein denotes Akt
T21925 519-523 Protein denotes AP-1
T21924 484-489 Protein denotes IL-17
T21923 359-364 Protein denotes IL-15
T21922 353-357 Protein denotes CD28
T21921 273-278 Protein denotes IL-17
T21920 163-166 Protein denotes Akt
T21919 81-84 Protein denotes Akt
R12043 T21919 T21972 themeOf Akt,activation
R12044 T21920 T21975 themeOf Akt,phosphorylated
R12046 T21921 T21973 themeOf IL-17,induction
R12047 T21924 T21976 themeOf IL-17,induction
R12049 T21927 T21977 themeOf IL-17,lacking
R12051 T21929 T21979 themeOf IL-17,upregulation
R12052 T21930 T21978 themeOf IL-17,blocking
R12053 T21931 T21980 themeOf IL-17,induction
R12056 T21973 T21974 themeOf induction,involvement

2_test

Id Subject Object Predicate Lexical cue
15642134-12810200-4202049 1263-1264 12810200 denotes 2
15642134-12632409-4202050 1265-1266 12632409 denotes 6
15642134-10880256-4202051 1267-1269 10880256 denotes 34
15642134-14872510-4202051 1267-1269 14872510 denotes 34
15642134-11920418-4202051 1267-1269 11920418 denotes 34

biosemtest

Id Subject Object Predicate Lexical cue
T18085 380-388 UMLS/C0026249 denotes our expe
T18078 811-821 UMLS/C0007634 denotes e data on
T18074 616-626 UMLS/C0282554 denotes as not act
T18061 1091-1098 UMLS/C0243122 denotes in the
T18048 1375-1383 UMLS/C1521840 denotes es in RA
T18037 131-135 UMLS/C1517945 denotes ivit
T18035 509-513 UMLS/C1321301 denotes rast
T18025 1184-1194 UMLS/C0439167 denotes uccessful
T18024 1099-1107 UMLS/C0439167 denotes IL-17 pr
T18023 139-147 UMLS/C0439167 denotes 2 hours
T18020 443-450 UMLS/C1704259 denotes so acti
T18019 39-46 UMLS/C1704259 denotes PI3K se
T17863 151-158 UMLS/C1292425 denotes e fact
T17850 1251-1260 UMLS/C0003864 denotes mal model
T17846 532-536 UMLS/C0162508 denotes rans
T17838 532-536 UMLS/C1333571 denotes rans
T17834 468-476 UMLS/C1314939 denotes he induc
T17833 244-255 UMLS/C1314939 denotes of PI3K in
T17828 730-741 UMLS/C0004083 denotes ith NF-κB h
T17827 1184-1194 UMLS/C1561536 denotes uccessful
T17826 1099-1107 UMLS/C1561536 denotes IL-17 pr
T17825 139-147 UMLS/C1561536 denotes 2 hours
T17822 15-21 UMLS/C1552603 denotes a down
T17819 1072-1080 UMLS/C0332206 denotes κB bindi
T17807 1059-1071 UMLS/C0521115 denotes ocking of NF
T17805 80-88 UMLS/C1704632 denotes Akt act
T17804 730-741 UMLS/C0596306 denotes ith NF-κB h
T17803 1315-1332 UMLS/C0086982 denotes y is an important
T17802 584-601 UMLS/C0086982 denotes hway for cytokine
T17801 537-564 UMLS/C0086982 denotes uction pathway, another imp
T17793 1091-1098 UMLS/C1167622 denotes in the
T17789 468-476 UMLS/C1947935 denotes he induc
T17782 1309-1314 UMLS/C1623218 denotes pathw
T17781 1115-1120 UMLS/C1623218 denotes y PDT
T17780 1006-1011 UMLS/C1623218 denotes the
T17779 855-860 UMLS/C1623218 denotes ing.
T17778 497-502 UMLS/C1623218 denotes BMC.
T17777 284-289 UMLS/C1623218 denotes . In
T17761 730-741 UMLS/C0439849 denotes ith NF-κB h
T17748 123-130 UMLS/C0439833 denotes s of ac
T17747 235-243 UMLS/C0332149 denotes volvemen
T17746 420-426 UMLS/C0332148 denotes the NF
T17745 1291-1304 UMLS/C0162340 denotes e IL-17 signa
T17743 222-230 UMLS/C1705535 denotes e possib
T17741 380-388 UMLS/C0018284 denotes our expe
T17734 764-772 UMLS/C1709908 denotes liver ac
T17723 1121-1129 UMLS/C0086860 denotes and LY2
T17716 1199-1209 UMLS/C1272703 denotes tion of an
T17714 532-536 UMLS/C0812312 denotes rans
T17708 705-715 UMLS/C0522506 denotes nase Akt i
T17707 28-38 UMLS/C0522506 denotes pathway of
T17706 716-722 UMLS/C0031727 denotes assoc
T17702 80-88 UMLS/C0871261 denotes Akt act
T17700 518-526 UMLS/C1979874 denotes AP-1 si
T17695 1309-1314 UMLS/C1825592 denotes pathw
T17694 1115-1120 UMLS/C1825592 denotes y PDT
T17693 1006-1011 UMLS/C1825592 denotes the
T17692 855-860 UMLS/C1825592 denotes ing.
T17691 497-502 UMLS/C1825592 denotes BMC.
T17690 284-289 UMLS/C1825592 denotes . In
T17677 1371-1374 UMLS/C0205314 denotes rap
T17672 1349-1356 UMLS/C0013879 denotes oping n
T17670 1264-1277 UMLS/C0599779 denotes ,6,34-36], un
T17669 865-872 UMLS/C0332268 denotes ata cle
T17658 72-79 UMLS/C0205289 denotes ponse o
T17577 764-772 UMLS/C0700287 denotes liver ac
T17563 235-243 UMLS/C2362652 denotes volvemen
T17553 878-882 UMLS/C1511726 denotes emon
T17552 827-831 UMLS/C1511726 denotes gnal
T17551 666-670 UMLS/C1511726 denotes n).
T17546 80-88 UMLS/C1706817 denotes Akt act
T17543 776-783 UMLS/C1705822 denotes ting si
T17542 950-955 UMLS/C0006823 denotes ortan
T17533 532-536 UP/P21525 denotes rans
T18013 151-158 UMLS/C1547059 denotes e fact
T18007 950-955 UMLS/C0344312 denotes ortan
T18000 1315-1332 UMLS/C0037080 denotes y is an important
T17999 584-601 UMLS/C0037080 denotes hway for cytokine
T17994 839-845 UMLS/C0037083 denotes g IL-1
T17993 795-802 UMLS/C0037083 denotes y cell
T17985 909-913 UMLS/C1705325 denotes esul
T17984 692-696 UMLS/C1705325 denotes down
T17983 259-263 UMLS/C1705325 denotes ind
T17982 50-54 UMLS/C1705325 denotes to
T17979 300-304 UMLS/C0449911 denotes fac
T17970 806-810 UMLS/C0439064 denotes s, t
T17968 616-626 UMLS/C1527036 denotes as not act
T17963 1039-1050 UMLS/C1706386 denotes wing simult
T17962 653-664 UMLS/C1706386 denotes data not sh
T17961 396-407 UMLS/C1706386 denotes it is most
T17954 1371-1374 UMLS/C1553390 denotes rap
T17940 210-221 UMLS/C1948023 denotes suggests t
T17916 909-913 UP/P42336 denotes esul
T17915 692-696 UP/P42336 denotes down
T17914 259-263 UP/P42336 denotes ind
T17913 50-54 UP/P42336 denotes to
T17902 1309-1314 UMLS/C0384648 denotes pathw
T17901 1115-1120 UMLS/C0384648 denotes y PDT
T17900 1006-1011 UMLS/C0384648 denotes the
T17899 855-860 UMLS/C0384648 denotes ing.
T17898 497-502 UMLS/C0384648 denotes BMC.
T17888 1349-1356 UMLS/C1705248 denotes oping n
T17885 110-116 UMLS/C1442450 denotes a grad
T17884 532-536 UMLS/C0087140 denotes rans
T17878 284-289 UMLS/C0384648 denotes . In
T17526 244-255 UMLS/C0205428 denotes of PI3K in
T17514 1091-1098 UMLS/C1689898 denotes in the
T17509 1184-1194 UMLS/C0441655 denotes uccessful
T17508 1099-1107 UMLS/C0441655 denotes IL-17 pr
T17507 139-147 UMLS/C0441655 denotes 2 hours
T17498 914-917 UP/Q8INB9 denotes ant
T17497 723-726 UP/Q8INB9 denotes ati
T17496 174-177 UP/Q8INB9 denotes pho
T17495 92-95 UP/Q8INB9 denotes ion
T17494 532-536 UP/A8MPH9 denotes rans
T17454 371-376 UMLS/C1149222 denotes ogens
T17440 371-376 UMLS/C0254610 denotes ogens
T17428 1059-1071 UMLS/C1548968 denotes ocking of NF
T17426 939-949 UMLS/C1879547 denotes d be an im
T17425 784-794 UMLS/C1879547 denotes nals in ma
T17424 636-645 UMLS/C1879547 denotes our exper
T17423 338-347 UMLS/C1879547 denotes anti-CD3
T17422 96-106 UMLS/C1879547 denotes at 1 hour
T17411 730-741 UMLS/C0699792 denotes ith NF-κB h
T17407 371-376 UMLS/C1334105 denotes ogens
T17384 606-615 UMLS/C1524094 denotes mokines,
T17370 1371-1374 UMLS/C1578513 denotes rap
T17368 1026-1031 UMLS/C1527178 denotes perim
T17367 1142-1150 UMLS/C0251991 denotes ering it
T17346 210-221 UMLS/C1292856 denotes suggests t
T17334 15-21 UMLS/C1706202 denotes a down
T17333 1133-1137 UMLS/C0084183 denotes 2. C
T17328 909-913 UMLS/C1368105 denotes esul
T17327 692-696 UMLS/C1368105 denotes down
T17326 259-263 UMLS/C1368105 denotes ind
T17325 50-54 UMLS/C1368105 denotes to
T17321 1039-1050 UMLS/C0681814 denotes wing simult
T17320 653-664 UMLS/C0681814 denotes data not sh
T17319 396-407 UMLS/C0681814 denotes it is most
T17316 1072-1080 UMLS/C1706084 denotes κB bindi
T17652 730-741 UMLS/C1704771 denotes ith NF-κB h
T17651 730-741 UMLS/C1704770 denotes ith NF-κB h
T17649 811-821 UMLS/C0449475 denotes e data on
T17646 443-450 UMLS/C1705987 denotes so acti
T17645 39-46 UMLS/C1705987 denotes PI3K se
T17643 909-913 UMLS/C1150481 denotes esul
T17642 692-696 UMLS/C1150481 denotes down
T17641 259-263 UMLS/C1150481 denotes ind
T17640 50-54 UMLS/C1150481 denotes to
T17636 671-674 UMLS/C1518422 denotes lth
T17635 632-635 UMLS/C1518422 denotes in
T17627 235-243 UMLS/C1705910 denotes volvemen
T17626 1375-1383 UMLS/C0599894 denotes es in RA
T17622 1210-1219 UMLS/C0205263 denotes i-IL-17 f
T17621 846-854 UMLS/C0205263 denotes are lac
T17620 484-493 UMLS/C0205263 denotes IL-17 in
T17619 271-280 UMLS/C0205263 denotes f IL-17 i
T17603 839-845 UMLS/C1710082 denotes g IL-1
T17602 795-802 UMLS/C1710082 denotes y cell
T17591 1349-1356 UMLS/C0021223 denotes oping n
T17590 1210-1219 UMLS/C1621983 denotes i-IL-17 f
T17589 484-493 UMLS/C1621983 denotes IL-17 in
T17588 271-280 UMLS/C1621983 denotes f IL-17 i
T17585 990-1002 UMLS/C0041904 denotes IL-17 in RA
T17300 1072-1080 UMLS/C1533157 denotes κB bindi
T17290 773-775 UMLS/C0319022 denotes iv
T17289 62-64 UMLS/C0319022 denotes ax
T17269 909-913 UMLS/C0285761 denotes esul
T17268 692-696 UMLS/C0285761 denotes down
T17267 259-263 UMLS/C0285761 denotes ind
T17266 50-54 UMLS/C0285761 denotes to
T17257 1072-1080 UMLS/C0028778 denotes κB bindi
T17255 1072-1080 UMLS/C0233660 denotes κB bindi
T17245 1091-1098 UMLS/C1145667 denotes in the
T17242 1091-1098 UMLS/C2349209 denotes in the
T17238 606-615 UMLS/C0079189 denotes mokines,
T17229 532-536 UMLS/C0085828 denotes rans
T17363 1309-1314 UMLS/C1522571 denotes pathw
T17362 1115-1120 UMLS/C1522571 denotes y PDT
T17361 1006-1011 UMLS/C1522571 denotes the
T17360 855-860 UMLS/C1522571 denotes ing.
T17359 497-502 UMLS/C1522571 denotes BMC.
T17358 284-289 UMLS/C1522571 denotes . In

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T19436 1381-1383 NN denotes RA
T19435 1378-1380 IN denotes in
T19434 1368-1377 NN denotes therapies
T19433 1359-1367 VB denotes targeted
T19432 1355-1358 JJ denotes new
T19431 1344-1354 VB denotes developing
T19430 1341-1343 IN denotes of
T19429 1333-1340 NN denotes element
T19428 1323-1332 JJ denotes important
T19427 1320-1322 DT denotes an
T19426 1317-1319 VB denotes is
T19425 1309-1316 NN denotes pathway
T19424 1299-1308 NN denotes signaling
T19423 1293-1298 NN denotes IL-17
T19422 1289-1292 DT denotes the
T19421 1275-1288 VB denotes understanding
T19420 1273-1274 -COMMA- denotes ,
T19419 1272-1273 -RRB- denotes ]
T19418 1263-1272 CD denotes 2,6,34-36
T19417 1262-1263 -LRB- denotes [
T19416 1255-1261 NN denotes models
T19415 1248-1254 NN denotes animal
T19414 1245-1247 IN denotes in
T19413 1235-1244 NN denotes arthritis
T19412 1222-1234 VB denotes ameliorating
T19411 1218-1221 IN denotes for
T19410 1207-1217 NN denotes anti-IL-17
T19409 1204-1206 IN denotes of
T19408 1194-1203 NN denotes induction
T19407 1183-1193 JJ denotes successful
T19406 1179-1182 CC denotes and
T19405 1168-1178 NN denotes activities
T19404 1152-1167 JJ denotes proinflammatory
T19403 1148-1151 PRP-DOLLAR- denotes its
T19402 1136-1147 VB denotes Considering
T19401 1126-1134 NN denotes LY294002
T19400 1122-1125 CC denotes and
T19395 1095-1098 DT denotes the
T19394 1092-1094 IN denotes in
T19393 1083-1091 NN denotes activity
T19392 1075-1082 NN denotes binding
T19391 1069-1074 NN denotes NF-κB
T19390 1066-1068 IN denotes of
T19389 1057-1065 NN denotes blocking
T19388 1044-1056 JJ denotes simultaneous
T19387 1036-1043 VB denotes showing
T19386 1024-1035 NN denotes experiments
T19385 1020-1023 PRP-DOLLAR- denotes our
T19384 1017-1019 IN denotes of
T19383 1011-1016 NN denotes basis
T19382 1007-1010 DT denotes the
T19381 1004-1006 IN denotes on
T19380 1002-1003 -COMMA- denotes ,
T19379 1000-1002 NN denotes RA
T19378 997-999 IN denotes in
T19377 991-996 NN denotes IL-17
T19376 988-990 IN denotes of
T19375 975-987 NN denotes upregulation
T19374 971-974 DT denotes the
T19373 968-970 IN denotes of
T19372 957-967 NN denotes arbitrator
T19371 947-956 JJ denotes important
T19370 944-946 DT denotes an
T19369 941-943 VB denotes be
T19368 935-940 MD denotes could
T19367 924-934 NN denotes activation
T19366 918-923 NN denotes NF-κB
T19365 908-917 JJ denotes resultant
T19364 904-907 CC denotes and
T19363 895-903 NN denotes PI3K/Akt
T19362 890-894 IN denotes that
T19361 877-889 VB denotes demonstrated
T19360 869-876 RB denotes clearly
T19359 864-868 NN denotes data
T19358 860-863 PRP-DOLLAR- denotes Our
T19357 851-858 VB denotes lacking
T19356 847-850 VB denotes are
T19355 841-846 NN denotes IL-17
T19354 832-840 VB denotes inducing
T19353 825-831 NN denotes signal
T19352 821-824 DT denotes the
T19351 818-820 IN denotes on
T19350 813-817 NN denotes data
T19349 809-812 DT denotes the
T19348 807-808 -COMMA- denotes ,
T19347 802-807 NN denotes types
T19346 797-801 NN denotes cell
T19345 792-796 JJ denotes many
T19344 789-791 IN denotes in
T19343 781-788 NN denotes signals
T19342 770-780 VB denotes activating
T19341 762-769 VB denotes deliver
T19340 759-761 TO denotes to
T19339 750-758 VB denotes reported
T19338 745-749 VB denotes been
T19337 740-744 VB denotes have
T19336 734-739 NN denotes NF-κB
T19335 729-733 IN denotes with
T19334 717-728 NN denotes association
T19333 714-716 IN denotes in
T19332 710-713 NN denotes Akt
T19331 703-709 NN denotes kinase
T19330 692-702 JJ denotes downstream
T19329 688-691 PRP-DOLLAR- denotes its
T19328 684-687 CC denotes and
T19327 679-683 NN denotes PI3K
T19326 670-678 IN denotes Although
T19325 667-668 -RRB- denotes )
T19324 662-667 VB denotes shown
T19323 658-661 RB denotes not
T19322 653-657 NN denotes data
T19321 652-653 -LRB- denotes (
T19320 640-651 NN denotes experiments
T19319 636-639 PRP-DOLLAR- denotes our
T19318 633-635 IN denotes in
T19317 623-632 VB denotes activated
T19316 619-622 RB denotes not
T19315 615-618 VB denotes was
T19314 613-614 -COMMA- denotes ,
T19313 593-613 NN denotes cytokines/chemokines
T19312 589-592 IN denotes for
T19311 581-588 NN denotes pathway
T19310 571-580 NN denotes signaling
T19309 561-570 JJ denotes important
T19308 553-560 DT denotes another
T19307 551-552 -COMMA- denotes ,
T19306 544-551 NN denotes pathway
T19305 531-543 NN denotes transduction
T19304 524-530 NN denotes signal
T19303 519-523 NN denotes AP-1
T19302 515-518 DT denotes the
T19301 513-514 -COMMA- denotes ,
T19300 505-513 NN denotes contrast
T19299 502-504 IN denotes In
T19298 496-500 NN denotes PBMC
T19297 493-495 NN denotes RA
T19296 490-492 IN denotes in
T19295 484-489 NN denotes IL-17
T19294 481-483 IN denotes of
T19293 471-480 NN denotes induction
T19292 467-470 DT denotes the
T19291 464-466 IN denotes in
T19290 455-463 VB denotes involved
T19289 446-454 RB denotes actively
T19288 441-445 RB denotes also
T19287 438-440 VB denotes is
T19286 430-437 NN denotes pathway
T19285 424-429 NN denotes NF-κB
T19284 420-423 DT denotes the
T19283 415-419 IN denotes that
T19282 408-414 JJ denotes likely
T19281 403-407 RB denotes most
T19280 400-402 VB denotes is
T19279 397-399 PRP denotes it
T19278 395-396 -COMMA- denotes ,
T19277 384-395 NN denotes experiments
T19276 380-383 PRP-DOLLAR- denotes our
T19275 377-379 IN denotes in
T19274 368-376 NN denotes mitogens
T19273 365-367 CC denotes or
T19272 359-364 NN denotes IL-15
T19271 357-358 -COMMA- denotes ,
T19270 339-357 JJ denotes anti-CD3/anti-CD28
T19269 336-338 IN denotes by
T19268 326-335 VB denotes activated
T19267 321-325 RB denotes also
T19266 317-320 VB denotes was
T19265 311-316 NN denotes NF-κB
T19264 306-310 IN denotes that
T19263 301-305 NN denotes fact
T19262 297-300 DT denotes the
T19261 294-296 IN denotes of
T19260 289-293 NN denotes view
T19259 286-288 IN denotes In
T19258 282-284 NN denotes RA
T19257 279-281 IN denotes in
T19256 273-278 NN denotes IL-17
T19255 270-272 IN denotes of
T19254 260-269 NN denotes induction
T19253 256-259 DT denotes the
T19252 253-255 IN denotes in
T19251 248-252 NN denotes PI3K
T19250 245-247 IN denotes of
T19249 233-244 NN denotes involvement
T19248 224-232 JJ denotes possible
T19247 220-223 DT denotes the
T19246 211-219 VB denotes suggests
T19245 199-210 NN denotes stimulation
T19244 190-198 JJ denotes anti-CD3
T19243 185-189 IN denotes upon
T19242 170-184 VB denotes phosphorylated
T19241 167-169 VB denotes is
T19240 163-166 NN denotes Akt
T19239 158-162 IN denotes that
T19238 153-157 NN denotes fact
T19237 149-152 DT denotes The
T19236 142-147 NN denotes hours
T19235 140-141 CD denotes 2
T19234 137-139 IN denotes at
T19233 128-136 NN denotes activity
T19232 125-127 IN denotes of
T19231 120-124 NN denotes loss
T19230 112-119 JJ denotes gradual
T19229 110-111 DT denotes a
T19228 106-109 CC denotes and
T19227 101-105 NN denotes hour
T19226 99-100 CD denotes 1
T19225 96-98 IN denotes at
T19224 85-95 NN denotes activation
T19223 81-84 NN denotes Akt
T19222 78-80 IN denotes of
T19221 69-77 NN denotes response
T19220 61-68 JJ denotes maximal
T19219 59-60 DT denotes a
T19218 54-58 VB denotes have
T19217 51-53 TO denotes to
T19216 44-50 VB denotes seemed
T19215 39-43 NN denotes PI3K
T19214 36-38 IN denotes of
T19213 28-35 NN denotes pathway
T19212 17-27 JJ denotes downstream
T19211 15-16 DT denotes a
T19210 11-14 IN denotes for
T19209 4-10 NN denotes search
T19208 0-3 DT denotes The
T19399 1117-1121 NN denotes PDTC
T19398 1114-1116 IN denotes by
T19397 1105-1113 NN denotes promoter
T19396 1099-1104 NN denotes IL-17
R10238 T19209 T19208 arg1Of search,The
R10239 T19209 T19210 arg1Of search,for
R10240 T19209 T19216 arg1Of search,seemed
R10241 T19209 T19218 arg1Of search,have
R10242 T19213 T19210 arg2Of pathway,for
R10243 T19213 T19211 arg1Of pathway,a
R10244 T19213 T19212 arg1Of pathway,downstream
R10245 T19213 T19214 arg1Of pathway,of
R10246 T19215 T19214 arg2Of PI3K,of
R10247 T19218 T19216 arg2Of have,seemed
R10248 T19218 T19217 arg1Of have,to
R10249 T19218 T19234 arg1Of have,at
R10250 T19221 T19219 arg1Of response,a
R10251 T19221 T19220 arg1Of response,maximal
R10252 T19221 T19222 arg1Of response,of
R10253 T19221 T19225 arg1Of response,at
R10254 T19221 T19228 arg1Of response,and
R10255 T19224 T19222 arg2Of activation,of
R10256 T19224 T19223 arg1Of activation,Akt
R10257 T19227 T19225 arg2Of hour,at
R10258 T19227 T19226 arg1Of hour,1
R10259 T19228 T19218 arg2Of and,have
R10260 T19231 T19228 arg2Of loss,and
R10261 T19231 T19229 arg1Of loss,a
R10262 T19231 T19230 arg1Of loss,gradual
R10263 T19231 T19232 arg1Of loss,of
R10264 T19233 T19232 arg2Of activity,of
R10265 T19236 T19234 arg2Of hours,at
R10266 T19236 T19235 arg1Of hours,2
R10267 T19238 T19237 arg1Of fact,The
R10268 T19238 T19246 arg1Of fact,suggests
R10269 T19240 T19241 arg1Of Akt,is
R10270 T19240 T19242 arg2Of Akt,phosphorylated
R10271 T19242 T19238 arg2Of phosphorylated,fact
R10272 T19242 T19239 arg1Of phosphorylated,that
R10273 T19242 T19241 arg2Of phosphorylated,is
R10274 T19242 T19243 arg1Of phosphorylated,upon
R10275 T19245 T19243 arg2Of stimulation,upon
R10276 T19245 T19244 arg1Of stimulation,anti-CD3
R10277 T19249 T19246 arg2Of involvement,suggests
R10278 T19249 T19247 arg1Of involvement,the
R10279 T19249 T19248 arg1Of involvement,possible
R10280 T19249 T19250 arg1Of involvement,of
R10281 T19249 T19252 arg1Of involvement,in
R10282 T19251 T19250 arg2Of PI3K,of
R10283 T19254 T19252 arg2Of induction,in
R10284 T19254 T19253 arg1Of induction,the
R10285 T19254 T19255 arg1Of induction,of
R10286 T19254 T19257 arg1Of induction,in
R10287 T19256 T19255 arg2Of IL-17,of
R10288 T19258 T19257 arg2Of RA,in
R10289 T19260 T19259 arg2Of view,In
R10290 T19260 T19261 arg1Of view,of
R10291 T19263 T19261 arg2Of fact,of
R10292 T19263 T19262 arg1Of fact,the
R10293 T19265 T19266 arg1Of NF-κB,was
R10294 T19265 T19268 arg2Of NF-κB,activated
R10295 T19268 T19263 arg2Of activated,fact
R10296 T19268 T19264 arg1Of activated,that
R10297 T19268 T19266 arg2Of activated,was
R10298 T19268 T19267 arg1Of activated,also
R10299 T19272 T19273 arg1Of IL-15,or
R10300 T19273 T19268 arg1Of or,activated
R10301 T19273 T19269 arg2Of or,by
R10302 T19273 T19270 arg1Of or,anti-CD3/anti-CD28
R10303 T19273 T19271 arg1Of or,","
R10304 T19273 T19275 arg1Of or,in
R10305 T19274 T19273 arg2Of mitogens,or
R10306 T19277 T19275 arg2Of experiments,in
R10307 T19277 T19276 arg1Of experiments,our
R10308 T19280 T19259 arg1Of is,In
R10309 T19280 T19278 arg1Of is,","
R10310 T19282 T19280 arg2Of likely,is
R10311 T19282 T19281 arg1Of likely,most
R10312 T19286 T19284 arg1Of pathway,the
R10313 T19286 T19285 arg1Of pathway,NF-κB
R10314 T19286 T19287 arg1Of pathway,is
R10315 T19286 T19290 arg2Of pathway,involved
R10316 T19290 T19279 arg1Of involved,it
R10317 T19290 T19280 arg1Of involved,is
R10318 T19290 T19282 arg1Of involved,likely
R10319 T19290 T19283 arg1Of involved,that
R10320 T19290 T19287 arg2Of involved,is
R10321 T19290 T19288 arg1Of involved,also
R10322 T19290 T19289 arg1Of involved,actively
R10323 T19290 T19291 arg1Of involved,in
R10324 T19293 T19291 arg2Of induction,in
R10325 T19293 T19292 arg1Of induction,the
R10326 T19293 T19294 arg1Of induction,of
R10327 T19293 T19296 arg1Of induction,in
R10328 T19295 T19294 arg2Of IL-17,of
R10329 T19298 T19296 arg2Of PBMC,in
R10330 T19298 T19297 arg1Of PBMC,RA
R10331 T19300 T19299 arg2Of contrast,In
R10332 T19306 T19302 arg1Of pathway,the
R10333 T19306 T19303 arg1Of pathway,AP-1
R10334 T19306 T19304 arg1Of pathway,signal
R10335 T19306 T19305 arg1Of pathway,transduction
R10336 T19306 T19307 arg1Of pathway,","
R10337 T19306 T19315 arg1Of pathway,was
R10338 T19306 T19317 arg2Of pathway,activated
R10339 T19311 T19307 arg2Of pathway,","
R10340 T19311 T19308 arg1Of pathway,another
R10341 T19311 T19309 arg1Of pathway,important
R10342 T19311 T19310 arg1Of pathway,signaling
R10343 T19311 T19312 arg1Of pathway,for
R10344 T19313 T19312 arg2Of cytokines/chemokines,for
R10345 T19317 T19299 arg1Of activated,In
R10346 T19317 T19301 arg1Of activated,","
R10347 T19317 T19314 arg1Of activated,","
R10348 T19317 T19315 arg2Of activated,was
R10349 T19317 T19316 arg1Of activated,not
R10350 T19317 T19318 arg1Of activated,in
R10351 T19320 T19318 arg2Of experiments,in
R10352 T19320 T19319 arg1Of experiments,our
R10353 T19320 T19321 arg1Of experiments,(
R10354 T19322 T19321 arg2Of data,(
R10355 T19322 T19324 arg2Of data,shown
R10356 T19324 T19323 arg1Of shown,not
R10357 T19325 T19321 arg3Of ),(
R10358 T19327 T19328 arg1Of PI3K,and
R10359 T19328 T19337 arg1Of and,have
R10360 T19328 T19338 arg1Of and,been
R10361 T19328 T19339 arg2Of and,reported
R10362 T19328 T19341 arg1Of and,deliver
R10363 T19332 T19328 arg2Of Akt,and
R10364 T19332 T19329 arg1Of Akt,its
R10365 T19332 T19330 arg1Of Akt,downstream
R10366 T19332 T19331 arg1Of Akt,kinase
R10367 T19332 T19333 arg1Of Akt,in
R10368 T19334 T19333 arg2Of association,in
R10369 T19334 T19335 arg1Of association,with
R10370 T19336 T19335 arg2Of NF-κB,with
R10371 T19339 T19326 arg2Of reported,Although
R10372 T19339 T19337 arg2Of reported,have
R10373 T19339 T19338 arg2Of reported,been
R10374 T19341 T19339 arg3Of deliver,reported
R10375 T19341 T19340 arg1Of deliver,to
R10376 T19341 T19344 arg1Of deliver,in
R10377 T19343 T19341 arg2Of signals,deliver
R10378 T19343 T19342 arg1Of signals,activating
R10379 T19347 T19344 arg2Of types,in
R10380 T19347 T19345 arg1Of types,many
R10381 T19347 T19346 arg1Of types,cell
R10382 T19350 T19349 arg1Of data,the
R10383 T19350 T19351 arg1Of data,on
R10384 T19350 T19356 arg1Of data,are
R10385 T19350 T19357 arg1Of data,lacking
R10386 T19353 T19351 arg2Of signal,on
R10387 T19353 T19352 arg1Of signal,the
R10388 T19353 T19354 arg1Of signal,inducing
R10389 T19355 T19354 arg2Of IL-17,inducing
R10390 T19357 T19326 arg1Of lacking,Although
R10391 T19357 T19348 arg1Of lacking,","
R10392 T19357 T19356 arg2Of lacking,are
R10393 T19359 T19358 arg1Of data,Our
R10394 T19359 T19361 arg1Of data,demonstrated
R10395 T19361 T19360 arg1Of demonstrated,clearly
R10396 T19363 T19364 arg1Of PI3K/Akt,and
R10397 T19364 T19368 arg1Of and,could
R10398 T19364 T19369 arg1Of and,be
R10399 T19367 T19364 arg2Of activation,and
R10400 T19367 T19365 arg1Of activation,resultant
R10401 T19367 T19366 arg1Of activation,NF-κB
R10402 T19369 T19361 arg2Of be,demonstrated
R10403 T19369 T19362 arg1Of be,that
R10404 T19369 T19368 arg2Of be,could
R10405 T19372 T19369 arg2Of arbitrator,be
R10406 T19372 T19370 arg1Of arbitrator,an
R10407 T19372 T19371 arg1Of arbitrator,important
R10408 T19372 T19373 arg1Of arbitrator,of
R10409 T19372 T19380 arg1Of arbitrator,","
R10410 T19372 T19381 arg1Of arbitrator,on
R10411 T19375 T19373 arg2Of upregulation,of
R10412 T19375 T19374 arg1Of upregulation,the
R10413 T19375 T19376 arg1Of upregulation,of
R10414 T19375 T19378 arg1Of upregulation,in
R10415 T19377 T19376 arg2Of IL-17,of
R10416 T19379 T19378 arg2Of RA,in
R10417 T19383 T19381 arg2Of basis,on
R10418 T19383 T19382 arg1Of basis,the
R10419 T19383 T19384 arg1Of basis,of
R10420 T19383 T19387 arg1Of basis,showing
R10421 T19386 T19384 arg2Of experiments,of
R10422 T19386 T19385 arg1Of experiments,our
R10423 T19389 T19387 arg2Of blocking,showing
R10424 T19389 T19388 arg1Of blocking,simultaneous
R10425 T19389 T19390 arg1Of blocking,of
R10426 T19389 T19394 arg1Of blocking,in
R10427 T19389 T19398 arg1Of blocking,by
R10428 T19393 T19390 arg2Of activity,of
R10429 T19393 T19391 arg1Of activity,NF-κB
R10430 T19393 T19392 arg1Of activity,binding
R10431 T19397 T19394 arg2Of promoter,in
R10432 T19397 T19395 arg1Of promoter,the
R10433 T19397 T19396 arg1Of promoter,IL-17
R10434 T19399 T19400 arg1Of PDTC,and
R10435 T19400 T19398 arg2Of and,by
R10436 T19401 T19400 arg2Of LY294002,and
R10437 T19402 T19406 arg1Of Considering,and
R10438 T19405 T19402 arg2Of activities,Considering
R10439 T19405 T19403 arg1Of activities,its
R10440 T19405 T19404 arg1Of activities,proinflammatory
R10441 T19406 T19426 arg1Of and,is
R10442 T19408 T19406 arg2Of induction,and
R10443 T19408 T19407 arg1Of induction,successful
R10444 T19408 T19409 arg1Of induction,of
R10445 T19408 T19411 arg1Of induction,for
R10446 T19410 T19409 arg2Of anti-IL-17,of
R10447 T19412 T19411 arg2Of ameliorating,for
R10448 T19412 T19414 arg1Of ameliorating,in
R10449 T19412 T19420 arg1Of ameliorating,","
R10450 T19412 T19421 modOf ameliorating,understanding
R10451 T19413 T19412 arg2Of arthritis,ameliorating
R10452 T19416 T19414 arg2Of models,in
R10453 T19416 T19415 arg1Of models,animal
R10454 T19416 T19417 arg1Of models,[
R10455 T19418 T19417 arg2Of "2,6,34-36",[
R10456 T19419 T19417 arg3Of ],[
R10457 T19425 T19421 arg2Of pathway,understanding
R10458 T19425 T19422 arg1Of pathway,the
R10459 T19425 T19423 arg1Of pathway,IL-17
R10460 T19425 T19424 arg1Of pathway,signaling
R10461 T19429 T19426 arg2Of element,is
R10462 T19429 T19427 arg1Of element,an
R10463 T19429 T19428 arg1Of element,important
R10464 T19429 T19430 arg1Of element,of
R10465 T19431 T19430 arg2Of developing,of
R10466 T19434 T19431 arg2Of therapies,developing
R10467 T19434 T19432 arg1Of therapies,new
R10468 T19434 T19433 arg2Of therapies,targeted
R10469 T19434 T19435 arg1Of therapies,in
R10470 T19436 T19435 arg2Of RA,in

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T19523 1293-1298 Protein denotes IL-17
T19522 1212-1217 Protein denotes IL-17
T19521 1099-1104 Protein denotes IL-17
T19520 991-996 Protein denotes IL-17
T19519 900-903 Protein denotes Akt
T19518 841-846 Protein denotes IL-17
T19517 710-713 Protein denotes Akt
T19516 519-523 Protein denotes AP-1
T19515 484-489 Protein denotes IL-17
T19514 359-364 Protein denotes IL-15
T19513 353-357 Protein denotes CD28
T19512 273-278 Protein denotes IL-17
T19511 163-166 Protein denotes Akt
T19510 81-84 Protein denotes Akt

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T20039 519-523 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T20038 900-903 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20037 710-713 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20036 163-166 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20035 81-84 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20034 900-903 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20033 710-713 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20006 353-357 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20001 344-347 http://www.uniprot.org/uniprot/P09693 denotes CD3
T20000 195-198 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19993 344-347 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19992 195-198 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19985 344-347 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19984 195-198 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19962 1293-1298 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19961 1212-1217 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19960 1099-1104 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19959 991-996 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19958 841-846 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19957 484-489 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19956 273-278 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19977 344-347 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19976 195-198 http://www.uniprot.org/uniprot/P20963 denotes CD3
T20032 163-166 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20031 81-84 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20030 900-903 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20029 710-713 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20028 163-166 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20027 81-84 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20016 359-364 http://www.uniprot.org/uniprot/P40933 denotes IL-15

GO-BP

Id Subject Object Predicate Lexical cue
T18214 524-543 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T18212 571-588 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18208 1299-1308 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18207 571-580 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18268 918-934 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18267 571-613 http://purl.obolibrary.org/obo/GO_0019221 denotes signaling pathway for cytokines/chemokines
T18266 524-551 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathway
T18265 524-551 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T18264 524-551 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T18263 524-551 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T18251 895-899 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18250 679-683 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18249 248-252 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18248 39-43 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18245 531-543 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

GO-MF

Id Subject Object Predicate Lexical cue
T19605 1069-1082 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T19602 1075-1082 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19589 895-899 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19588 679-683 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19587 248-252 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19586 39-43 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19580 359-364 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19555 1293-1298 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19554 1212-1217 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19553 1099-1104 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19552 991-996 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19551 841-846 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19550 484-489 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19549 273-278 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17

GO-CC

Id Subject Object Predicate Lexical cue
T19615 797-801 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T18172 1136-1384 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.
T18171 860-1135 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T18170 670-859 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T18169 502-669 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T18168 286-501 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T18167 149-285 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T18166 0-148 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T188 0-148 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T189 149-285 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T190 286-501 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T191 502-669 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T192 670-859 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T193 860-1135 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T194 1136-1384 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.

ICD10

Id Subject Object Predicate Lexical cue
T19620 1235-1244 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

simple1

Id Subject Object Predicate Lexical cue
T19930 1293-1298 Protein denotes IL-17
T19929 1212-1217 Protein denotes IL-17
T19928 1099-1104 Protein denotes IL-17
T19927 991-996 Protein denotes IL-17
T19926 900-903 Protein denotes Akt
T19925 841-846 Protein denotes IL-17
T19924 710-713 Protein denotes Akt
T19923 519-523 Protein denotes AP-1
T19922 484-489 Protein denotes IL-17
T19921 359-364 Protein denotes IL-15
T19920 353-357 Protein denotes CD28
T19919 273-278 Protein denotes IL-17
T19918 163-166 Protein denotes Akt
T19917 81-84 Protein denotes Akt

DLUT931

Id Subject Object Predicate Lexical cue
T20286 1194-1203 Positive_regulation denotes induction
T20285 975-987 Positive_regulation denotes upregulation
T20284 851-858 Negative_regulation denotes lacking
T20283 832-840 Positive_regulation denotes inducing
T20282 717-728 Binding denotes association
T20281 623-632 Positive_regulation denotes activated
T20280 455-463 Regulation denotes involved
T20279 471-480 Positive_regulation denotes induction
T20278 233-244 Regulation denotes involvement
T20274 85-95 Positive_regulation denotes activation
T20232 1293-1298 Protein denotes IL-17
T20231 1212-1217 Protein denotes IL-17
T20230 1099-1104 Protein denotes IL-17
T20229 991-996 Protein denotes IL-17
T20228 900-903 Protein denotes Akt
T20227 841-846 Protein denotes IL-17
T20226 710-713 Protein denotes Akt
T20225 519-523 Protein denotes AP-1
T20224 484-489 Protein denotes IL-17
T20223 359-364 Protein denotes IL-15
T20222 353-357 Protein denotes CD28
T20221 273-278 Protein denotes IL-17
T20220 163-166 Protein denotes Akt
T20219 81-84 Protein denotes Akt
T20276 170-184 Phosphorylation denotes phosphorylated
T20275 69-77 Regulation denotes response
T20277 260-269 Positive_regulation denotes induction
R10699 T20219 T20274 themeOf Akt,activation
R10700 T20220 T20276 themeOf Akt,phosphorylated
R10701 T20221 T20277 themeOf IL-17,induction
R10702 T20224 T20279 themeOf IL-17,induction
R10703 T20225 T20281 themeOf AP-1,activated
R10704 T20226 T20282 themeOf Akt,association
R10705 T20227 T20283 themeOf IL-17,inducing
R10706 T20229 T20285 themeOf IL-17,upregulation
R10707 T20231 T20286 themeOf IL-17,induction
R10726 T20274 T20275 themeOf activation,response
R10727 T20277 T20278 themeOf induction,involvement
R10728 T20279 T20280 themeOf induction,involved
R10729 T20283 T20284 themeOf inducing,lacking

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T21863 717-739 Binding denotes association with NF-κB
T21859 256-284 Gene_expression denotes the induction of IL-17 in RA
T21858 256-284 Positive_regulation denotes the induction of IL-17 in RA
T21856 163-184 Phosphorylation denotes Akt is phosphorylated
T21851 81-95 Positive_regulation denotes Akt activation
T21850 971-1003 Positive_regulation denotes the upregulation of IL-17 in RA,
T21839 1183-1273 Gene_expression denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21838 1183-1273 Positive_regulation denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21837 464-500 Positive_regulation denotes in the induction of IL-17 in RA PBMC
T21836 464-500 Gene_expression denotes in the induction of IL-17 in RA PBMC
T21832 190-210 Positive_regulation denotes anti-CD3 stimulation
T21828 908-934 Positive_regulation denotes resultant NF-κB activation
T21826 821-846 Positive_regulation denotes the signal inducing IL-17
T21825 821-846 Gene_expression denotes the signal inducing IL-17
T21806 39-43 Protein denotes PI3K
T21801 895-903 Protein denotes PI3K/Akt
T21796 270-278 Protein denotes of IL-17
T21795 306-316 Protein denotes that NF-κB
T21788 1099-1104 Protein denotes IL-17
T21786 493-500 Entity denotes RA PBMC
T21783 918-923 Protein denotes NF-κB
T21780 841-846 Protein denotes IL-17
T21772 348-357 Protein denotes anti-CD28
T21764 195-198 Protein denotes CD3
T21759 729-739 Protein denotes with NF-κB
T21754 603-613 Protein denotes chemokines
T21751 679-683 Protein denotes PI3K
T21749 688-713 Protein denotes its downstream kinase Akt
T21739 420-437 Protein denotes the NF-κB pathway
T21736 792-807 Entity denotes many cell types
T21719 988-996 Protein denotes of IL-17
T21716 900-903 Protein denotes Akt
T21712 368-376 Entity denotes mitogens
T21708 515-614 Protein denotes the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines,
T21703 1095-1113 Entity denotes the IL-17 promoter
T21695 493-495 Protein denotes RA
T21684 1126-1134 Entity denotes LY294002
T21676 321-347 Protein denotes also activated by anti-CD3
T21674 163-166 Protein denotes Akt
T21672 553-613 Protein denotes another important signaling pathway for cytokines/chemokines
T21670 688-713 Protein denotes its downstream kinase Akt
T21665 245-252 Protein denotes of PI3K
T21663 895-903 Protein denotes PI3K/Akt
T21659 688-713 Protein denotes its downstream kinase Akt
T21656 282-284 Protein denotes RA
T21638 81-84 Protein denotes Akt
T21634 1293-1298 Protein denotes IL-17
T21625 1000-1002 Protein denotes RA
T21621 1204-1217 Protein denotes of anti-IL-17
T21618 359-364 Protein denotes IL-15
T21651 481-489 Protein denotes of IL-17
T21650 1381-1383 Protein denotes RA
R11924 T21621 T21838 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11925 T21621 T21839 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11931 T21651 T21836 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11933 T21638 T21851 themeOf Akt,Akt activation
R11935 T21651 T21837 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11944 T21674 T21856 themeOf Akt,Akt is phosphorylated
R11945 T21759 T21863 themeOf with NF-κB,association with NF-κB
R11948 T21764 T21832 themeOf CD3,anti-CD3 stimulation
R11956 T21780 T21825 themeOf IL-17,the signal inducing IL-17
R11957 T21780 T21826 themeOf IL-17,the signal inducing IL-17
R11960 T21783 T21828 themeOf NF-κB,resultant NF-κB activation
R11967 T21796 T21858 themeOf of IL-17,the induction of IL-17 in RA
R11968 T21796 T21859 themeOf of IL-17,the induction of IL-17 in RA
R11980 T21703 T21788 partOf the IL-17 promoter,IL-17
R11986 T21719 T21850 themeOf of IL-17,"the upregulation of IL-17 in RA,"

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T21445 1383-1384 . denotes .
T21444 1381-1383 NNP denotes RA
T21443 1378-1380 IN denotes in
T21442 1368-1377 NNS denotes therapies
T21441 1359-1367 JJ denotes targeted
T21440 1355-1358 JJ denotes new
T21439 1344-1354 VBG denotes developing
T21438 1341-1343 IN denotes of
T21437 1333-1340 NN denotes element
T21436 1323-1332 JJ denotes important
T21435 1320-1322 DT denotes an
T21434 1317-1319 VBZ denotes is
T21433 1309-1316 NN denotes pathway
T21432 1299-1308 VBG denotes signaling
T21431 1293-1298 NNP denotes IL-17
T21430 1289-1292 DT denotes the
T21429 1275-1288 VBG denotes understanding
T21428 1273-1274 , denotes ,
T21427 1272-1273 NNP denotes ]
T21426 1263-1272 CD denotes 2,6,34-36
T21425 1262-1263 NNP denotes [
T21424 1255-1261 NNS denotes models
T21423 1248-1254 NN denotes animal
T21422 1245-1247 IN denotes in
T21421 1235-1244 NNS denotes arthritis
T21420 1222-1234 VBG denotes ameliorating
T21419 1218-1221 IN denotes for
T21418 1207-1217 JJ denotes anti-IL-17
T21417 1204-1206 IN denotes of
T21416 1194-1203 NN denotes induction
T21415 1183-1193 JJ denotes successful
T21414 1179-1182 CC denotes and
T21413 1168-1178 NNS denotes activities
T21412 1152-1167 JJ denotes proinflammatory
T21411 1148-1151 PRP$ denotes its
T21410 1136-1147 VBG denotes Considering
T21409 1134-1135 . denotes .
T21408 1126-1134 NNP denotes LY294002
T21407 1122-1125 CC denotes and
T21406 1117-1121 NNP denotes PDTC
T21405 1114-1116 IN denotes by
T21404 1105-1113 NN denotes promoter
T21403 1099-1104 NNP denotes IL-17
T21402 1095-1098 DT denotes the
T21401 1092-1094 IN denotes in
T21400 1083-1091 NN denotes activity
T21399 1075-1082 JJ denotes binding
T21398 1069-1074 JJ denotes NF-κB
T21397 1066-1068 IN denotes of
T21396 1057-1065 VBG denotes blocking
T21395 1044-1056 JJ denotes simultaneous
T21394 1036-1043 VBG denotes showing
T21393 1024-1035 NNS denotes experiments
T21392 1020-1023 PRP$ denotes our
T21391 1017-1019 IN denotes of
T21390 1011-1016 NN denotes basis
T21389 1007-1010 DT denotes the
T21388 1004-1006 IN denotes on
T21387 1002-1003 , denotes ,
T21386 1000-1002 NNP denotes RA
T21385 997-999 IN denotes in
T21384 991-996 NNP denotes IL-17
T21383 988-990 IN denotes of
T21382 975-987 NN denotes upregulation
T21381 971-974 DT denotes the
T21380 968-970 IN denotes of
T21379 957-967 NN denotes arbitrator
T21378 947-956 JJ denotes important
T21377 944-946 DT denotes an
T21376 941-943 VB denotes be
T21375 935-940 MD denotes could
T21374 924-934 NN denotes activation
T21373 918-923 NN denotes NF-κB
T21372 908-917 JJ denotes resultant
T21371 904-907 CC denotes and
T21370 895-903 NNP denotes PI3K/Akt
T21369 890-894 IN denotes that
T21368 877-889 VBD denotes demonstrated
T21367 869-876 RB denotes clearly
T21366 864-868 NNS denotes data
T21365 860-863 PRP$ denotes Our
T21364 858-859 . denotes .
T21363 851-858 VBG denotes lacking
T21362 847-850 VBP denotes are
T21361 841-846 NNP denotes IL-17
T21360 832-840 VBG denotes inducing
T21359 825-831 NN denotes signal
T21358 821-824 DT denotes the
T21357 818-820 IN denotes on
T21356 813-817 NNS denotes data
T21355 809-812 DT denotes the
T21354 807-808 , denotes ,
T21353 802-807 NNS denotes types
T21352 797-801 NN denotes cell
T21351 792-796 JJ denotes many
T21350 789-791 IN denotes in
T21349 781-788 NNS denotes signals
T21348 770-780 VBG denotes activating
T21347 762-769 VB denotes deliver
T21346 759-761 TO denotes to
T21345 750-758 VBN denotes reported
T21344 745-749 VBN denotes been
T21343 740-744 VBP denotes have
T21342 734-739 NNP denotes NF-κB
T21341 729-733 IN denotes with
T21340 717-728 NN denotes association
T21339 714-716 IN denotes in
T21338 710-713 NNP denotes Akt
T21337 703-709 NN denotes kinase
T21336 692-702 JJ denotes downstream
T21335 688-691 PRP$ denotes its
T21334 684-687 CC denotes and
T21333 679-683 NNP denotes PI3K
T21332 670-678 IN denotes Although
T21331 668-669 . denotes .
T21330 667-668 -RRB- denotes )
T21329 662-667 VBN denotes shown
T21328 658-661 RB denotes not
T21327 653-657 NNS denotes data
T21326 652-653 -LRB- denotes (
T21325 640-651 NNS denotes experiments
T21324 636-639 PRP$ denotes our
T21323 633-635 IN denotes in
T21322 623-632 VBN denotes activated
T21321 619-622 RB denotes not
T21320 615-618 VBD denotes was
T21319 613-614 , denotes ,
T21318 593-613 NNS denotes cytokines/chemokines
T21317 589-592 IN denotes for
T21316 581-588 NN denotes pathway
T21315 571-580 VBG denotes signaling
T21314 561-570 JJ denotes important
T21313 553-560 DT denotes another
T21312 551-552 , denotes ,
T21311 544-551 NN denotes pathway
T21310 531-543 NN denotes transduction
T21309 524-530 NN denotes signal
T21308 519-523 NNP denotes AP-1
T21307 515-518 DT denotes the
T21306 513-514 , denotes ,
T21305 505-513 NN denotes contrast
T21304 502-504 IN denotes In
T21303 500-501 . denotes .
T21302 496-500 NNP denotes PBMC
T21301 493-495 NNP denotes RA
T21300 490-492 IN denotes in
T21299 484-489 NNP denotes IL-17
T21298 481-483 IN denotes of
T21297 471-480 NN denotes induction
T21296 467-470 DT denotes the
T21295 464-466 IN denotes in
T21294 455-463 VBN denotes involved
T21293 446-454 RB denotes actively
T21292 441-445 RB denotes also
T21291 438-440 VBZ denotes is
T21290 430-437 NN denotes pathway
T21289 424-429 NNP denotes NF-κB
T21288 420-423 DT denotes the
T21287 415-419 IN denotes that
T21286 408-414 JJ denotes likely
T21285 403-407 RBS denotes most
T21284 400-402 VBZ denotes is
T21283 397-399 PRP denotes it
T21282 395-396 , denotes ,
T21281 384-395 NNS denotes experiments
T21280 380-383 PRP$ denotes our
T21279 377-379 IN denotes in
T21278 368-376 NNS denotes mitogens
T21277 365-367 CC denotes or
T21276 359-364 NN denotes IL-15
T21275 357-358 , denotes ,
T21274 348-357 NN denotes anti-CD28
T21273 347-348 NN denotes /
T21272 339-347 JJ denotes anti-CD3
T21271 336-338 IN denotes by
T21270 326-335 VBN denotes activated
T21269 321-325 RB denotes also
T21268 317-320 VBD denotes was
T21267 311-316 NNP denotes NF-κB
T21266 306-310 IN denotes that
T21265 301-305 NN denotes fact
T21264 297-300 DT denotes the
T21263 294-296 IN denotes of
T21262 289-293 NN denotes view
T21261 286-288 IN denotes In
T21260 284-285 . denotes .
T21259 282-284 NNP denotes RA
T21258 279-281 IN denotes in
T21257 273-278 NNP denotes IL-17
T21256 270-272 IN denotes of
T21255 260-269 NN denotes induction
T21254 256-259 DT denotes the
T21253 253-255 IN denotes in
T21252 248-252 NNP denotes PI3K
T21251 245-247 IN denotes of
T21250 233-244 NN denotes involvement
T21249 224-232 JJ denotes possible
T21248 220-223 DT denotes the
T21247 211-219 VBZ denotes suggests
T21246 199-210 NN denotes stimulation
T21245 190-198 JJ denotes anti-CD3
T21244 185-189 IN denotes upon
T21243 170-184 VBN denotes phosphorylated
T21242 167-169 VBZ denotes is
T21236 142-147 NNS denotes hours
T21235 140-141 CD denotes 2
T21234 137-139 IN denotes at
T21233 128-136 NN denotes activity
T21232 125-127 IN denotes of
T21231 120-124 NN denotes loss
T21230 112-119 JJ denotes gradual
T21229 110-111 DT denotes a
T21228 106-109 CC denotes and
T21227 101-105 NN denotes hour
T21226 99-100 CD denotes 1
T21225 96-98 IN denotes at
T21224 85-95 NN denotes activation
T21223 81-84 NNP denotes Akt
T21222 78-80 IN denotes of
T21221 69-77 NN denotes response
T21220 61-68 JJ denotes maximal
T21219 59-60 DT denotes a
T21218 54-58 VB denotes have
T21217 51-53 TO denotes to
T21216 44-50 VBD denotes seemed
T21215 39-43 NNP denotes PI3K
T21214 36-38 IN denotes of
T21213 28-35 NN denotes pathway
T21212 17-27 JJ denotes downstream
T21211 15-16 DT denotes a
T21210 11-14 IN denotes for
T21209 4-10 NN denotes search
T21208 0-3 DT denotes The
T21241 163-166 NNP denotes Akt
T21240 158-162 IN denotes that
T21239 153-157 NN denotes fact
T21238 149-152 DT denotes The
T21237 147-148 . denotes .
R11542 T21208 T21209 det The,search
R11543 T21209 T21216 nsubj search,seemed
R11544 T21210 T21209 prep for,search
R11546 T21211 T21213 det a,pathway
R11547 T21212 T21213 amod downstream,pathway
R11548 T21213 T21210 pobj pathway,for
R11550 T21214 T21213 prep of,pathway
R11551 T21215 T21214 pobj PI3K,of
R11552 T21216 T21216 ROOT seemed,seemed
R11554 T21217 T21218 aux to,have
R11555 T21218 T21216 xcomp have,seemed
R11557 T21219 T21221 det a,response
R11558 T21220 T21221 amod maximal,response
R11559 T21221 T21218 dobj response,have
R11561 T21222 T21221 prep of,response
R11562 T21223 T21224 compound Akt,activation
R11564 T21224 T21222 pobj activation,of
R11565 T21225 T21218 prep at,have
R11566 T21226 T21227 nummod 1,hour
R11567 T21227 T21225 pobj hour,at
R11569 T21228 T21227 cc and,hour
R11570 T21229 T21231 det a,loss
R11572 T21230 T21231 amod gradual,loss
R11573 T21231 T21227 conj loss,hour
R11574 T21232 T21231 prep of,loss
R11575 T21233 T21232 pobj activity,of
R11576 T21234 T21231 prep at,loss
R11577 T21235 T21236 nummod 2,hours
R11579 T21236 T21234 pobj hours,at
R11583 T21237 T21216 punct .,seemed
R11584 T21238 T21239 det The,fact
R11586 T21239 T21239 ROOT fact,fact
R11588 T21240 T21242 mark that,is
R11589 T21241 T21242 nsubj Akt,is
R11593 T21242 T21239 acl is,fact
R11595 T21243 T21242 acomp phosphorylated,is
R11596 T21244 T21243 prep upon,phosphorylated
R11597 T21245 T21246 amod anti-CD3,stimulation
R11599 T21246 T21244 pobj stimulation,upon
R11600 T21247 T21243 auxpass suggests,phosphorylated
R11601 T21248 T21250 det the,involvement
R11603 T21249 T21250 amod possible,involvement
R11604 T21250 T21247 dobj involvement,suggests
R11606 T21251 T21250 prep of,involvement
R11607 T21252 T21251 pobj PI3K,of
R11608 T21253 T21250 prep in,involvement
R11609 T21254 T21255 det the,induction
R11611 T21255 T21253 pobj induction,in
R11612 T21256 T21255 prep of,induction
R11613 T21257 T21256 pobj IL-17,of
R11615 T21258 T21255 prep in,induction
R11616 T21259 T21258 pobj RA,in
R11617 T21260 T21239 punct .,fact
R11619 T21261 T21284 prep In,is
R11620 T21262 T21261 pobj view,In
R11621 T21263 T21262 prep of,view
R11623 T21264 T21265 det the,fact
R11624 T21265 T21263 pobj fact,of
R11626 T21266 T21270 mark that,activated
R11627 T21267 T21270 nsubjpass NF-κB,activated
R11628 T21268 T21270 auxpass was,activated
R11629 T21269 T21270 advmod also,activated
R11630 T21270 T21265 acl activated,fact
R11631 T21271 T21270 agent by,activated
R11632 T21272 T21274 amod anti-CD3,anti-CD28
R11634 T21273 T21274 compound /,anti-CD28
R11635 T21274 T21271 pobj anti-CD28,by
R11636 T21275 T21274 punct ",",anti-CD28
R11637 T21276 T21274 conj IL-15,anti-CD28
R11639 T21277 T21276 cc or,IL-15
R11643 T21278 T21276 conj mitogens,IL-15
R11644 T21279 T21278 prep in,mitogens
R11645 T21280 T21281 poss our,experiments
R11646 T21281 T21279 pobj experiments,in
R11648 T21282 T21284 punct ",",is
R11649 T21283 T21284 nsubj it,is
R11651 T21284 T21284 ROOT is,is
R11652 T21285 T21286 advmod most,likely
R11653 T21286 T21284 acomp likely,is
R11655 T21287 T21294 mark that,involved
R11656 T21288 T21290 det the,pathway
R11657 T21289 T21290 compound NF-κB,pathway
R11658 T21290 T21294 nsubjpass pathway,involved
R11660 T21291 T21294 auxpass is,involved
R11661 T21292 T21294 advmod also,involved
R11662 T21293 T21294 advmod actively,involved
R11664 T21294 T21286 ccomp involved,likely
R11665 T21295 T21294 prep in,involved
R11666 T21296 T21297 det the,induction
R11668 T21297 T21295 pobj induction,in
R11669 T21298 T21297 prep of,induction
R11670 T21299 T21298 pobj IL-17,of
R11672 T21300 T21297 prep in,induction
R11673 T21301 T21302 compound RA,PBMC
R11674 T21302 T21300 pobj PBMC,in
R11676 T21303 T21284 punct .,is
R11677 T21304 T21322 prep In,activated
R11678 T21305 T21304 pobj contrast,In
R11679 T21306 T21322 punct ",",activated
R11680 T21307 T21311 det the,pathway
R11681 T21308 T21311 compound AP-1,pathway
R11683 T21309 T21311 compound signal,pathway
R11684 T21310 T21311 compound transduction,pathway
R11685 T21311 T21322 nsubjpass pathway,activated
R11686 T21312 T21311 punct ",",pathway
R11688 T21313 T21316 det another,pathway
R11689 T21314 T21316 amod important,pathway
R11691 T21315 T21316 amod signaling,pathway
R11692 T21316 T21311 conj pathway,pathway
R11693 T21317 T21316 prep for,pathway
R11695 T21318 T21317 pobj cytokines/chemokines,for
R11698 T21319 T21322 punct ",",activated
R11699 T21320 T21322 auxpass was,activated
R11701 T21321 T21322 neg not,activated
R11702 T21322 T21322 ROOT activated,activated
R11703 T21323 T21322 prep in,activated
R11705 T21324 T21325 poss our,experiments
R11706 T21325 T21323 pobj experiments,in
R11707 T21326 T21325 punct (,experiments
R11709 T21327 T21329 nsubj data,shown
R11710 T21328 T21329 neg not,shown
R11712 T21329 T21322 conj shown,activated
R11713 T21330 T21329 punct ),shown
R11714 T21331 T21322 punct .,activated
R11715 T21332 T21345 mark Although,reported
R11716 T21334 T21333 cc and,PI3K
R11717 T21333 T21345 nsubjpass PI3K,reported
R11718 T21335 T21337 poss its,kinase
R11719 T21431 T21432 nsubj IL-17,signaling
R11720 T21432 T21434 nsubj signaling,is
R11721 T21433 T21434 nsubj pathway,is
R11722 T21336 T21337 amod downstream,kinase
R11723 T21434 T21429 ccomp is,understanding
R11724 T21435 T21437 det an,element
R11725 T21436 T21437 amod important,element
R11726 T21437 T21434 attr element,is
R11727 T21438 T21437 prep of,element
R11728 T21439 T21438 pcomp developing,of
R11729 T21440 T21442 amod new,therapies
R11730 T21337 T21338 compound kinase,Akt
R11731 T21441 T21442 amod targeted,therapies
R11732 T21442 T21439 dobj therapies,developing
R11733 T21443 T21439 prep in,developing
R11734 T21444 T21443 pobj RA,in
R11735 T21338 T21333 conj Akt,PI3K
R11736 T21445 T21410 punct .,Considering
R11737 T21339 T21333 prep in,PI3K
R11738 T21340 T21339 pobj association,in
R11739 T21341 T21340 prep with,association
R11740 T21342 T21341 pobj NF-κB,with
R11741 T21343 T21345 aux have,reported
R11742 T21344 T21345 auxpass been,reported
R11743 T21345 T21363 advcl reported,lacking
R11744 T21346 T21347 aux to,deliver
R11745 T21347 T21345 xcomp deliver,reported
R11746 T21348 T21349 amod activating,signals
R11747 T21349 T21347 dobj signals,deliver
R11750 T21350 T21347 prep in,deliver
R11752 T21351 T21353 amod many,types
R11753 T21352 T21353 compound cell,types
R11754 T21353 T21350 pobj types,in
R11755 T21354 T21363 punct ",",lacking
R11756 T21355 T21356 det the,data
R11757 T21356 T21363 nsubj data,lacking
R11759 T21357 T21356 prep on,data
R11761 T21358 T21359 det the,signal
R11762 T21359 T21357 pobj signal,on
R11764 T21360 T21359 acl inducing,signal
R11766 T21361 T21360 dobj IL-17,inducing
R11767 T21362 T21363 aux are,lacking
R11770 T21363 T21363 ROOT lacking,lacking
R11772 T21364 T21363 punct .,lacking
R11775 T21365 T21366 poss Our,data
R11780 T21366 T21368 nsubj data,demonstrated
R11781 T21367 T21368 advmod clearly,demonstrated
R11783 T21368 T21368 ROOT demonstrated,demonstrated
R11786 T21369 T21376 mark that,be
R11789 T21370 T21376 nsubj PI3K/Akt,be
R11793 T21371 T21370 cc and,PI3K/Akt
R11794 T21372 T21374 amod resultant,activation
R11795 T21373 T21374 compound NF-κB,activation
R11797 T21374 T21370 conj activation,PI3K/Akt
R11800 T21375 T21376 aux could,be
R11811 T21376 T21368 ccomp be,demonstrated
R11813 T21377 T21379 det an,arbitrator
R11814 T21378 T21379 amod important,arbitrator
R11817 T21379 T21376 attr arbitrator,be
R11821 T21380 T21379 prep of,arbitrator
R11822 T21381 T21382 det the,upregulation
R11823 T21382 T21380 pobj upregulation,of
R11828 T21383 T21382 prep of,upregulation
R11831 T21384 T21383 pobj IL-17,of
R11833 T21385 T21382 prep in,upregulation
R11835 T21386 T21385 pobj RA,in
R11840 T21387 T21379 punct ",",arbitrator
R11841 T21388 T21379 prep on,arbitrator
R11843 T21389 T21390 det the,basis
R11844 T21390 T21388 pobj basis,on
R11845 T21391 T21390 prep of,basis
R11846 T21392 T21393 poss our,experiments
R11848 T21393 T21391 pobj experiments,of
R11849 T21394 T21393 acl showing,experiments
R11853 T21395 T21396 amod simultaneous,blocking
R11855 T21396 T21394 dobj blocking,showing
R11858 T21397 T21396 prep of,blocking
R11860 T21398 T21400 amod NF-κB,activity
R11862 T21399 T21400 amod binding,activity
R11864 T21400 T21397 pobj activity,of
R11866 T21401 T21400 prep in,activity
R11868 T21402 T21404 det the,promoter
R11871 T21403 T21404 compound IL-17,promoter
R11872 T21404 T21401 pobj promoter,in
R11874 T21405 T21396 prep by,blocking
R11883 T21406 T21405 pobj PDTC,by
R11884 T21407 T21406 cc and,PDTC
R11887 T21408 T21406 conj LY294002,PDTC
R11890 T21409 T21368 punct .,demonstrated
R11893 T21410 T21410 ROOT Considering,Considering
R11895 T21411 T21413 poss its,activities
R11898 T21412 T21413 amod proinflammatory,activities
R11900 T21413 T21410 dobj activities,Considering
R11902 T21414 T21413 cc and,activities
R11903 T21415 T21416 amod successful,induction
R11908 T21416 T21413 conj induction,activities
R11914 T21417 T21416 prep of,induction
R11916 T21418 T21417 pobj anti-IL-17,of
R11917 T21419 T21418 prep for,anti-IL-17
R11918 T21420 T21419 pcomp ameliorating,for
R11919 T21421 T21420 dobj arthritis,ameliorating
R11920 T21422 T21420 prep in,ameliorating
R11921 T21423 T21424 compound animal,models
R11922 T21424 T21422 pobj models,in
R11923 T21425 T21427 compound [,]
R11926 T21426 T21427 compound "2,6,34-36",]
R11927 T21427 T21424 appos ],models
R11928 T21428 T21427 punct ",",]
R11929 T21429 T21420 conj understanding,ameliorating
R11930 T21430 T21431 det the,IL-17

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T19792 1194-1203 Positive_regulation denotes induction
T19791 1293-1298 Protein denotes IL-17
T19790 1207-1217 Protein denotes anti-IL-17
T19789 1057-1065 Negative_regulation denotes blocking
T19788 1057-1065 Negative_regulation denotes blocking
T19787 1057-1065 Negative_regulation denotes blocking
T19786 1057-1065 Negative_regulation denotes blocking
T19785 1075-1082 Binding denotes binding
T19784 1075-1082 Binding denotes binding
T19783 1075-1082 Binding denotes binding
T19782 1075-1082 Binding denotes binding
T19781 924-934 Positive_regulation denotes activation
T19780 1099-1113 Protein denotes IL-17 promoter
T19779 1069-1074 Protein denotes NF-κB
T19778 918-923 Protein denotes NF-κB
T19777 900-903 Protein denotes Akt
T19776 895-899 Protein denotes PI3K
T19775 717-728 Binding denotes association
T19774 717-728 Binding denotes association
T19773 841-846 Protein denotes IL-17
T19772 734-739 Protein denotes NF-κB
T19771 710-713 Protein denotes Akt
T19770 679-683 Protein denotes PI3K
T19769 519-523 Protein denotes AP-1
T19768 455-463 Regulation denotes involved
T19767 455-463 Regulation denotes involved
T19766 471-480 Positive_regulation denotes induction
T19765 471-480 Positive_regulation denotes induction
T19764 326-335 Positive_regulation denotes activated
T19763 326-335 Positive_regulation denotes activated
T19762 326-335 Positive_regulation denotes activated
T19761 493-500 Protein denotes RA PBMC
T19760 484-489 Protein denotes IL-17
T19759 424-429 Protein denotes NF-κB
T19758 359-364 Protein denotes IL-15
T19757 348-357 Protein denotes anti-CD28
T19756 339-347 Protein denotes anti-CD3
T19755 311-316 Protein denotes NF-κB
T19754 233-244 Regulation denotes involvement
T19753 260-269 Positive_regulation denotes induction
T19752 170-184 Phosphorylation denotes phosphorylated
T19751 273-278 Protein denotes IL-17
T19750 248-252 Protein denotes PI3K
T19749 195-198 Protein denotes CD3
T19748 163-166 Protein denotes Akt
T19747 120-124 Negative_regulation denotes loss
T19746 85-95 Positive_regulation denotes activation
T19745 81-84 Protein denotes Akt
T19744 39-43 Protein denotes PI3K
R10550 T19745 T19746 themeOf Akt,activation
R10551 T19746 T19747 themeOf activation,loss
R10552 T19748 T19752 themeOf Akt,phosphorylated
R10553 T19750 T19754 causeOf PI3K,involvement
R10554 T19751 T19753 themeOf IL-17,induction
R10555 T19753 T19754 themeOf induction,involvement
R10556 T19755 T19762 themeOf NF-κB,activated
R10557 T19755 T19763 themeOf NF-κB,activated
R10558 T19755 T19764 themeOf NF-κB,activated
R10559 T19756 T19762 causeOf anti-CD3,activated
R10560 T19757 T19763 causeOf anti-CD28,activated
R10561 T19758 T19764 causeOf IL-15,activated
R10562 T19759 T19767 causeOf NF-κB,involved
R10563 T19759 T19768 causeOf NF-κB,involved
R10564 T19760 T19765 themeOf IL-17,induction
R10565 T19761 T19766 themeOf RA PBMC,induction
R10566 T19765 T19767 themeOf induction,involved
R10567 T19766 T19768 themeOf induction,involved
R10568 T19771 T19775 themeOf Akt,association
R10569 T19772 T19774 themeOf NF-κB,association
R10570 T19772 T19775 themeOf NF-κB,association
R10571 T19777 T19784 themeOf Akt,binding
R10572 T19778 T19781 themeOf NF-κB,activation
R10573 T19779 T19782 themeOf NF-κB,binding
R10574 T19779 T19784 themeOf NF-κB,binding
R10575 T19779 T19785 themeOf NF-κB,binding
R10576 T19780 T19783 themeOf IL-17 promoter,binding
R10577 T19780 T19785 themeOf IL-17 promoter,binding
R10578 T19782 T19786 themeOf binding,blocking
R10579 T19783 T19787 themeOf binding,blocking
R10580 T19784 T19788 themeOf binding,blocking
R10581 T19785 T19789 themeOf binding,blocking
R10582 T19790 T19792 themeOf anti-IL-17,induction

testone

Id Subject Object Predicate Lexical cue
T17026 1105-1113 Entity denotes promoter
T17025 1075-1082 Binding denotes binding
T17024 1057-1065 Negative_regulation denotes blocking
T17023 975-987 Positive_regulation denotes upregulation
T17022 851-858 Negative_regulation denotes lacking
T17021 832-840 Positive_regulation denotes inducing
T17020 717-728 Binding denotes association
T17019 471-480 Positive_regulation denotes induction
T17018 455-463 Regulation denotes involved
T17017 260-269 Positive_regulation denotes induction
T17016 233-244 Regulation denotes involvement
T17015 170-184 Phosphorylation denotes phosphorylated
T17014 85-95 Positive_regulation denotes activation
T16966 1293-1298 Protein denotes IL-17
T16965 1212-1217 Protein denotes IL-17
T16964 1099-1104 Protein denotes IL-17
T16963 991-996 Protein denotes IL-17
T16962 900-903 Protein denotes Akt
T16961 841-846 Protein denotes IL-17
T16960 710-713 Protein denotes Akt
T16959 519-523 Protein denotes AP-1
T16958 484-489 Protein denotes IL-17
T16957 359-364 Protein denotes IL-15
T16956 353-357 Protein denotes CD28
T16955 273-278 Protein denotes IL-17
T16954 163-166 Protein denotes Akt
T16953 81-84 Protein denotes Akt
R9230 T16953 T17014 themeOf Akt,activation
R9231 T16954 T17015 themeOf Akt,phosphorylated
R9232 T16955 T17017 themeOf IL-17,induction
R9233 T16958 T17019 themeOf IL-17,induction
R9234 T16960 T17020 themeOf Akt,association
R9235 T16961 T17021 themeOf IL-17,inducing
R9236 T16961 T17022 themeOf IL-17,lacking
R9237 T16963 T17023 themeOf IL-17,upregulation
R9262 T17017 T17016 themeOf induction,involvement
R9263 T17019 T17018 themeOf induction,involved
R9264 T17025 T17024 themeOf binding,blocking
R9265 T17026 T16964 partOf promoter,IL-17
R9266 T17026 T17025 themeOf promoter,binding