PMC:1064895 / 25786-26702 JSONTXT

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{"project":"GO-MF","denotations":[{"id":"T19604","span":{"begin":674,"end":687},"obj":"http://purl.obolibrary.org/obo/GO_0051059"},{"id":"T19603","span":{"begin":568,"end":583},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T19601","span":{"begin":680,"end":687},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T19600","span":{"begin":568,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T19599","span":{"begin":563,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0008140"},{"id":"T19598","span":{"begin":762,"end":766},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19597","span":{"begin":620,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19596","span":{"begin":319,"end":323},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19595","span":{"begin":758,"end":761},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19594","span":{"begin":616,"end":619},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19593","span":{"begin":491,"end":494},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19592","span":{"begin":463,"end":466},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19591","span":{"begin":416,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19590","span":{"begin":315,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T19585","span":{"begin":790,"end":794},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T19584","span":{"begin":98,"end":102},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T19548","span":{"begin":857,"end":862},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T19547","span":{"begin":249,"end":254},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T19546","span":{"begin":36,"end":41},"obj":"http://purl.obolibrary.org/obo/GO_0030367"}],"text":"We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation. We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor. It is interesting that a series of evidence supports crosstalk between NF-κB and p38. In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]. Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation. The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments."}

{"project":"sentences","denotations":[{"id":"T18165","span":{"begin":807,"end":916},"obj":"Sentence"},{"id":"T18164","span":{"begin":590,"end":806},"obj":"Sentence"},{"id":"T18163","span":{"begin":421,"end":589},"obj":"Sentence"},{"id":"T18162","span":{"begin":335,"end":420},"obj":"Sentence"},{"id":"T18161","span":{"begin":213,"end":334},"obj":"Sentence"},{"id":"T18160","span":{"begin":0,"end":212},"obj":"Sentence"},{"id":"T182","span":{"begin":0,"end":212},"obj":"Sentence"},{"id":"T183","span":{"begin":213,"end":334},"obj":"Sentence"},{"id":"T184","span":{"begin":335,"end":420},"obj":"Sentence"},{"id":"T185","span":{"begin":421,"end":589},"obj":"Sentence"},{"id":"T186","span":{"begin":590,"end":806},"obj":"Sentence"},{"id":"T187","span":{"begin":807,"end":916},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation. We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor. It is interesting that a series of evidence supports crosstalk between NF-κB and p38. In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]. Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation. The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments."}

{"project":"simple1","denotations":[{"id":"T19916","span":{"begin":857,"end":862},"obj":"Protein"},{"id":"T19915","span":{"begin":563,"end":583},"obj":"Protein"},{"id":"T19914","span":{"begin":558,"end":562},"obj":"Protein"},{"id":"T19913","span":{"begin":434,"end":446},"obj":"Protein"},{"id":"T19912","span":{"begin":249,"end":254},"obj":"Protein"},{"id":"T19911","span":{"begin":36,"end":41},"obj":"Protein"},{"id":"T19910","span":{"begin":24,"end":27},"obj":"Protein"}],"text":"We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation. We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor. It is interesting that a series of evidence supports crosstalk between NF-κB and p38. In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]. Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation. The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments."}

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identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation. We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor. It is interesting that a series of evidence supports crosstalk between NF-κB and p38. In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]. Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation. The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments."}

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