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PMC:1064895 / 2407-5647 JSONTXT

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test3

Id Subject Object Predicate Lexical cue
T2227 2738-2743 Protein denotes IL-17
T2226 2603-2608 Protein denotes IL-17
T2225 2555-2558 Protein denotes CD8
T2224 2546-2549 Protein denotes CD4
T2223 2525-2535 Gene_expression denotes production
T2222 2519-2524 Protein denotes IL-17
T2221 2508-2515 Positive_regulation denotes trigger
T2220 2480-2485 Protein denotes IL-23
T2219 2319-2329 Gene_expression denotes production
T2218 2313-2318 Protein denotes IL-17
T2217 2302-2309 Positive_regulation denotes trigger
T2216 2221-2226 Protein denotes IL-15
T2215 2183-2186 Protein denotes CD4
T2214 2171-2179 Gene_expression denotes produced
T2213 2046-2051 Protein denotes IL-17
T2212 1856-1882 Protein denotes leukemia inhibitory factor
T2211 1847-1851 Protein denotes IL-6
T2210 1833-1843 Gene_expression denotes production
T2209 1818-1828 Positive_regulation denotes stimulates
T2208 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2207 1701-1706 Protein denotes RANKL
T2206 1688-1697 Positive_regulation denotes induction
T2205 1628-1633 Protein denotes IL-17
T2204 1565-1573 Gene_expression denotes produced
T2203 1513-1518 Protein denotes IL-17
T2202 1507-1511 Protein denotes IL-1
T2201 1497-1502 Protein denotes TNF-α
T2200 1400-1404 Protein denotes IL-8
T2199 1391-1395 Protein denotes IL-6
T2198 1384-1390 Positive_regulation denotes induce
T2197 1293-1298 Protein denotes IL-17
T2196 918-923 Protein denotes TNF-α
T2195 908-913 Protein denotes IL-18
T2194 901-906 Protein denotes IL-15
T2193 895-899 Protein denotes IL-6
T2192 889-893 Protein denotes IL-1
T2191 801-813 Protein denotes interferon-γ
T2190 792-796 Protein denotes IL-2
T2189 355-373 Protein denotes interleukin (IL)-1
T2188 320-349 Protein denotes tumor necrosis factor (TNF)-α
T2187 306-316 Negative_regulation denotes inhibitors
T2186 3099-3104 Protein denotes IL-17
T2185 3012-3015 Protein denotes Akt
T2184 2834-2839 Protein denotes IL-17
T2183 2738-2743 Protein denotes IL-17
T2182 2603-2608 Protein denotes IL-17
T2181 2555-2558 Protein denotes CD8
T2180 2546-2549 Protein denotes CD4
T2179 2519-2524 Protein denotes IL-17
T2178 2480-2485 Protein denotes IL-23
T2177 2313-2318 Protein denotes IL-17
T2176 2221-2226 Protein denotes IL-15
T2175 2183-2186 Protein denotes CD4
T2174 2046-2051 Protein denotes IL-17
T2173 1856-1882 Protein denotes leukemia inhibitory factor
T2172 1847-1851 Protein denotes IL-6
T2171 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2170 1701-1706 Protein denotes RANKL
T2169 1628-1633 Protein denotes IL-17
T2168 1513-1518 Protein denotes IL-17
T2167 1507-1511 Protein denotes IL-1
T2166 1497-1502 Protein denotes TNF-α
T2165 1400-1404 Protein denotes IL-8
T2164 1391-1395 Protein denotes IL-6
T2163 1293-1298 Protein denotes IL-17
T2162 918-923 Protein denotes TNF-α
T2161 908-913 Protein denotes IL-18
T2160 901-906 Protein denotes IL-15
T2159 895-899 Protein denotes IL-6
T2158 889-893 Protein denotes IL-1
T2157 801-813 Protein denotes interferon-γ
T2156 792-796 Protein denotes IL-2
T2155 355-373 Protein denotes interleukin (IL)-1
T2154 320-349 Protein denotes tumor necrosis factor (TNF)-α
T2232 3099-3104 Protein denotes IL-17
T2231 3012-3015 Protein denotes Akt
T2230 2840-2850 Gene_expression denotes production
T2229 2834-2839 Protein denotes IL-17
T2228 2744-2754 Gene_expression denotes production
R1090 T2188 T2187 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1091 T2189 T2187 themeOf interleukin (IL)-1,inhibitors
R1092 T2197 T2198 causeOf IL-17,induce
R1093 T2199 T2198 themeOf IL-6,induce
R1094 T2200 T2198 themeOf IL-8,induce
R1095 T2201 T2204 themeOf TNF-α,produced
R1096 T2202 T2204 themeOf IL-1,produced
R1097 T2203 T2204 themeOf IL-17,produced
R1098 T2207 T2206 themeOf RANKL,induction
R1099 T2208 T2207 equivalentTo receptor activator of nuclear factor κB [NF-κB] ligand,RANKL
R1100 T2210 T2209 themeOf production,stimulates
R1101 T2211 T2210 themeOf IL-6,production
R1102 T2213 T2214 themeOf IL-17,produced
R1103 T2218 T2219 themeOf IL-17,production
R1104 T2219 T2217 themeOf production,trigger
R1105 T2220 T2221 causeOf IL-23,trigger
R1106 T2222 T2223 themeOf IL-17,production
R1107 T2223 T2221 themeOf production,trigger
R1108 T2227 T2228 themeOf IL-17,production
R1109 T2229 T2230 themeOf IL-17,production

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T3761 3051-3065 Gene_expression denotes overproduction
T3760 3035-3043 Regulation denotes involved
T3759 2840-2850 Gene_expression denotes production
T3730 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3729 1701-1706 Protein denotes RANKL
T3728 1628-1633 Protein denotes IL-17
T3727 1513-1518 Protein denotes IL-17
T3726 1507-1511 Protein denotes IL-1
T3725 1497-1502 Protein denotes TNF-α
T3724 1400-1404 Protein denotes IL-8
T3723 1391-1395 Protein denotes IL-6
T3722 1293-1298 Protein denotes IL-17
T3721 918-923 Protein denotes TNF-α
T3720 908-913 Protein denotes IL-18
T3719 901-906 Protein denotes IL-15
T3718 895-899 Protein denotes IL-6
T3717 889-893 Protein denotes IL-1
T3716 801-813 Protein denotes interferon-γ
T3715 792-796 Protein denotes IL-2
T3714 355-373 Protein denotes interleukin (IL)-1
T3713 320-349 Protein denotes tumor necrosis factor (TNF)-α
T3758 2744-2754 Gene_expression denotes production
T3757 2525-2535 Gene_expression denotes production
T3756 2228-2236 Localization denotes secreted
T3755 2302-2309 Positive_regulation denotes trigger
T3754 2319-2329 Gene_expression denotes production
T3753 2171-2179 Gene_expression denotes produced
T3752 1818-1828 Positive_regulation denotes stimulates
T3751 1833-1843 Gene_expression denotes production
T3750 1774-1782 Regulation denotes involved
T3749 1643-1651 Positive_regulation denotes activate
T3748 1688-1697 Positive_regulation denotes induction
T3747 1384-1390 Positive_regulation denotes induce
T3746 306-316 Negative_regulation denotes inhibitors
T3745 3099-3104 Protein denotes IL-17
T3744 3012-3015 Protein denotes Akt
T3743 2834-2839 Protein denotes IL-17
T3742 2738-2743 Protein denotes IL-17
T3741 2603-2608 Protein denotes IL-17
T3740 2555-2558 Protein denotes CD8
T3739 2546-2549 Protein denotes CD4
T3738 2519-2524 Protein denotes IL-17
T3737 2480-2485 Protein denotes IL-23
T3736 2313-2318 Protein denotes IL-17
T3735 2221-2226 Protein denotes IL-15
T3734 2183-2186 Protein denotes CD4
T3733 2046-2051 Protein denotes IL-17
T3732 1856-1882 Protein denotes leukemia inhibitory factor
T3731 1847-1851 Protein denotes IL-6
R1776 T3713 T3746 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1777 T3714 T3746 themeOf interleukin (IL)-1,inhibitors
R1778 T3723 T3747 themeOf IL-6,induce
R1779 T3724 T3747 themeOf IL-8,induce
R1781 T3728 T3749 causeOf IL-17,activate
R1783 T3729 T3748 themeOf RANKL,induction
R1784 T3731 T3751 themeOf IL-6,production
R1788 T3732 T3751 themeOf leukemia inhibitory factor,production
R1789 T3733 T3753 themeOf IL-17,produced
R1792 T3735 T3756 themeOf IL-15,secreted
R1795 T3736 T3754 themeOf IL-17,production
R1799 T3738 T3757 themeOf IL-17,production
R1801 T3742 T3758 themeOf IL-17,production
R1805 T3743 T3759 themeOf IL-17,production
R1808 T3745 T3761 themeOf IL-17,overproduction
R1812 T3748 T3750 themeOf induction,involved
R1815 T3748 T3749 themeOf induction,activate
R1817 T3751 T3752 themeOf production,stimulates
R1818 T3751 T3752 themeOf production,stimulates
R1819 T3754 T3755 themeOf production,trigger
R1820 T3761 T3760 themeOf overproduction,involved

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T4648 3051-3065 Gene_expression denotes overproduction
T4647 2840-2850 Gene_expression denotes production
T4646 2744-2754 Gene_expression denotes production
T4645 2508-2515 Positive_regulation denotes trigger
T4644 2525-2535 Gene_expression denotes production
T4643 2228-2236 Localization denotes secreted
T4642 2319-2329 Gene_expression denotes production
T4641 2302-2309 Positive_regulation denotes trigger
T4640 1833-1843 Gene_expression denotes production
T4639 1818-1828 Positive_regulation denotes stimulates
T4638 1688-1697 Positive_regulation denotes induction
T4637 1336-1344 Localization denotes secreted
T4636 1384-1390 Positive_regulation denotes induce
T4635 306-316 Negative_regulation denotes inhibitors
T4634 3099-3104 Protein denotes IL-17
T4633 3012-3015 Protein denotes Akt
T4632 2834-2839 Protein denotes IL-17
T4631 2738-2743 Protein denotes IL-17
T4630 2603-2608 Protein denotes IL-17
T4629 2555-2558 Protein denotes CD8
T4628 2546-2549 Protein denotes CD4
T4627 2519-2524 Protein denotes IL-17
T4626 2480-2485 Protein denotes IL-23
T4625 2313-2318 Protein denotes IL-17
T4624 2221-2226 Protein denotes IL-15
T4623 2183-2186 Protein denotes CD4
T4622 2046-2051 Protein denotes IL-17
T4621 1856-1882 Protein denotes leukemia inhibitory factor
T4620 1847-1851 Protein denotes IL-6
T4619 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T4618 1701-1706 Protein denotes RANKL
T4617 1628-1633 Protein denotes IL-17
T4616 1513-1518 Protein denotes IL-17
T4615 1507-1511 Protein denotes IL-1
T4614 1497-1502 Protein denotes TNF-α
T4613 1400-1404 Protein denotes IL-8
T4612 1391-1395 Protein denotes IL-6
T4611 1293-1298 Protein denotes IL-17
T4610 918-923 Protein denotes TNF-α
T4609 908-913 Protein denotes IL-18
T4608 901-906 Protein denotes IL-15
T4607 895-899 Protein denotes IL-6
T4606 889-893 Protein denotes IL-1
T4605 801-813 Protein denotes interferon-γ
T4604 792-796 Protein denotes IL-2
T4603 355-373 Protein denotes interleukin (IL)-1
T4602 320-349 Protein denotes tumor necrosis factor (TNF)-α
R2458 T4602 T4635 themeOf tumor necrosis factor (TNF)-α,inhibitors
R2459 T4603 T4635 themeOf interleukin (IL)-1,inhibitors
R2463 T4611 T4637 themeOf IL-17,secreted
R2464 T4612 T4636 themeOf IL-6,induce
R2465 T4613 T4636 themeOf IL-8,induce
R2466 T4618 T4638 themeOf RANKL,induction
R2468 T4620 T4640 themeOf IL-6,production
R2469 T4621 T4640 themeOf leukemia inhibitory factor,production
R2470 T4624 T4643 themeOf IL-15,secreted
R2471 T4625 T4642 themeOf IL-17,production
R2472 T4626 T4645 causeOf IL-23,trigger
R2473 T4627 T4644 themeOf IL-17,production
R2475 T4631 T4646 themeOf IL-17,production
R2476 T4632 T4647 themeOf IL-17,production
R2477 T4634 T4648 themeOf IL-17,overproduction
R2479 T4640 T4639 themeOf production,stimulates
R2480 T4640 T4639 themeOf production,stimulates
R2481 T4642 T4641 themeOf production,trigger
R2482 T4644 T4645 themeOf production,trigger

2_test

Id Subject Object Predicate Lexical cue
15642134-12810425-4202008 256-257 12810425 denotes 1
15642134-12810200-4202009 511-512 12810200 denotes 2
15642134-9683554-4202010 1037-1038 9683554 denotes 3
15642134-10524679-4202011 1224-1225 10524679 denotes 4
15642134-8676080-4202012 1421-1422 8676080 denotes 5
15642134-12632409-4202013 1586-1587 12632409 denotes 6
15642134-12594294-4202014 1806-1807 12594294 denotes 7
15642134-9182915-4202015 2029-2030 9182915 denotes 8
15642134-11669582-4202015 2029-2030 11669582 denotes 8
15642134-11592370-4202015 2029-2030 11592370 denotes 8
15642134-10225978-4202016 2213-2215 10225978 denotes 11
15642134-10323452-4202017 2216-2218 10323452 denotes 12
15642134-10679127-4202018 2426-2428 10679127 denotes 13
15642134-12707317-4202019 2569-2571 12707317 denotes 14
15642134-10323452-4202020 2677-2679 10323452 denotes 12
15642134-12677240-4202021 2680-2682 12677240 denotes 15
15642134-15022319-4202022 2683-2685 15022319 denotes 16

biosemtest

Id Subject Object Predicate Lexical cue
T2747 1428-1432 UMLS/C0323983 denotes s cy
T2746 1411-1422 UMLS/C0016030 denotes roblasts [5
T2745 860-870 UMLS/C0016030 denotes broblast c
T2744 2761-2768 UMLS/C1527428 denotes s uncer
T2743 2787-2794 UMLS/C0449450 denotes t study
T2742 3218-3229 UMLS/C0302350 denotes utic strate
T2741 486-497 UMLS/C0302350 denotes herapeutic
T2740 1692-1701 UMLS/C1621983 denotes ction of
T2739 1403-1407 UMLS/C1527432 denotes 8 by
T2738 320-341 UP/P13296 denotes tumor necrosis factor
T2737 767-774 UMLS/C2348040 denotes erived
T2736 965-969 UMLS/C0323983 denotes s pa
T2735 823-829 UMLS/C0444497 denotes ints o
T2734 242-248 UMLS/C0444497 denotes joints
T2733 109-114 UMLS/C0444497 denotes joint
T2732 3106-3111 UMLS/C1825592 denotes n RA.
T2731 2609-2614 UMLS/C1825592 denotes in jo
T2730 1543-1553 UMLS/C1882134 denotes erties; se
T2729 2052-2057 UMLS/C1825592 denotes in sy
T2728 1632-1637 UMLS/C1825592 denotes 7 can
T2727 1517-1522 UMLS/C1825592 denotes 7 has
T2726 718-724 UMLS/C2348044 denotes eries
T2725 2280-2288 UMLS/C0700287 denotes ed to be
T2724 656-663 UMLS/C1704243 denotes argest
T2723 2412-2421 UMLS/C0332324 denotes ive pathw
T2722 2795-2800 UMLS/C1705923 denotes we us
T2721 2674-2681 UMLS/C1705923 denotes s [12,1
T2720 728-735 UMLS/C1705923 denotes tudies
T2719 2145-2159 UMLS/C0029408 denotes rthritis (OA),
T2718 518-524 UMLS/C0700321 denotes ittle
T2717 274-282 UMLS/C0205210 denotes clinical
T2716 3199-3209 UMLS/C0439755 denotes ons for ne
T2715 2486-2491 UMLS/C1423526 denotes could
T2714 1296-1301 UMLS/C1825592 denotes 17 is
T2713 1601-1613 UMLS/C0700325 denotes rvations dem
T2712 1839-1849 UMLS/C1548180 denotes tion of IL
T2711 320-341 UP/P59694 denotes tumor necrosis factor
T2710 2840-2856 UMLS/C1819444 denotes production in PB
T2709 2744-2760 UMLS/C1819444 denotes production remai
T2708 2525-2541 UMLS/C1819444 denotes production from
T2707 2319-2335 UMLS/C1819444 denotes production in RA
T2706 1448-1456 UMLS/C0543488 denotes erest fo
T2705 2404-2411 UMLS/C0038317 denotes d sensi
T2704 320-341 UP/P19101 denotes tumor necrosis factor
T2703 2514-2521 UMLS/C0032930 denotes r of IL
T2702 1543-1553 UMLS/C0871161 denotes erties; se
T2701 2308-2315 UMLS/C0032930 denotes r of IL
T2700 1111-1118 UMLS/C0003320 denotes igen sp
T2699 3214-3217 UMLS/C0205314 denotes rap
T2698 3147-3150 UMLS/C0205314 denotes igh
T2697 482-485 UMLS/C0205314 denotes ew
T2696 2593-2605 UMLS/C1880177 denotes bution of IL
T2695 1987-2000 UMLS/C0007589 denotes entiate and a
T2694 2096-2102 UMLS/C1299351 denotes in pa
T2693 198-203 UMLS/C0205309 denotes known
T2692 320-341 UP/O77764 denotes tumor necrosis factor
T2691 274-282 UMLS/C1555900 denotes clinical
T2690 3133-3138 UMLS/C0337876 denotes rovid
T2689 3033-3038 UMLS/C0337876 denotes e inv
T2688 320-341 UP/P51435 denotes tumor necrosis factor
T2687 881-890 UMLS/C0332257 denotes cluding I
T2686 2860-2864 UMLS/C1321301 denotes f pa
T2685 2378-2382 UMLS/C1321301 denotes by c
T2684 2342-2376 UMLS/C1321301 denotes eral blood mononuclear cells (PBMC
T2683 767-774 UMLS/C1441547 denotes erived
T2682 2422-2430 UMLS/C1704259 denotes ys [13].
T2681 590-608 UMLS/C0004364 denotes utoimmune disease
T2680 3125-3132 UMLS/C1546471 denotes might
T2679 3169-3181 UMLS/C0543483 denotes nesis of RA
T2678 320-341 UP/Q8MKG8 denotes tumor necrosis factor
T2677 845-855 UMLS/C0024432 denotes crophage a
T2676 76-87 UMLS/C0024432 denotes macrophages
T2675 2422-2430 UMLS/C1705987 denotes ys [13].
T2674 3012-3016 UMLS/C1150481 denotes Akt
T2673 664-668 UMLS/C0007634 denotes ell
T2672 188-193 UMLS/C0007634 denotes cells
T2671 320-341 UP/P59684 denotes tumor necrosis factor
T2670 3169-3181 UMLS/C0699748 denotes nesis of RA
T2669 1020-1032 UMLS/C0543483 denotes hogenesis of
T2668 1020-1032 UMLS/C0699748 denotes hogenesis of
T2667 574-586 UMLS/C0699748 denotes athogenesis
T2666 574-586 UMLS/C0543483 denotes athogenesis
T2665 498-510 UMLS/C0870325 denotes pplications
T2664 274-282 UMLS/C1611832 denotes clinical
T2663 1119-1127 UMLS/C1552740 denotes cific T
T2662 518-524 UMLS/C2700395 denotes ittle
T2661 1543-1553 UMLS/C1705419 denotes erties; se
T2660 2868-2876 UMLS/C1705908 denotes ts with
T2659 2131-2139 UMLS/C1705908 denotes ts with
T2658 2106-2114 UMLS/C1705908 denotes ts with
T2657 320-341 UP/P36939 denotes tumor necrosis factor
T2656 320-341 UP/Q8JFG3 denotes tumor necrosis factor
T2655 2248-2269 UMLS/C0001280 denotes ted macrophages, has
T2654 1543-1553 UMLS/C1705912 denotes erties; se
T2653 129-140 UMLS/C0020507 denotes hyperplasia
T2652 1705-1710 UMLS/C1704863 denotes L (re
T2651 1151-1167 UMLS/C0009331 denotes e II collagen, a
T2650 656-663 UMLS/C0443228 denotes argest
T2649 1411-1422 UMLS/C1546634 denotes roblasts [5
T2648 860-870 UMLS/C1546634 denotes broblast c
T2647 320-341 UP/P33620 denotes tumor necrosis factor
T2646 2928-2933 UMLS/C0037088 denotes that
T2645 881-890 UMLS/C2700399 denotes cluding I
T2644 1692-1701 UMLS/C0205263 denotes ction of
T2643 1387-1393 UMLS/C0205263 denotes uce IL
T2642 320-341 UP/P79374 denotes tumor necrosis factor
T2641 120-128 UMLS/C1550315 denotes synovial
T2640 168-176 UMLS/C0439180 denotes released
T2639 1403-1407 UMLS/C0079633 denotes 8 by
T2638 2096-2102 UMLS/C0205250 denotes in pa
T2637 320-341 UP/Q06599 denotes tumor necrosis factor
T2636 320-341 UP/P59695 denotes tumor necrosis factor
T2635 320-341 UP/P79337 denotes tumor necrosis factor
T2634 3192-3198 UMLS/C0016884 denotes direct
T2633 320-341 UP/P59693 denotes tumor necrosis factor
T2632 320-341 UP/O35734 denotes tumor necrosis factor
T2631 3125-3132 UMLS/C0332294 denotes might
T2630 3125-3132 UMLS/C1274040 denotes might
T2629 3199-3209 UMLS/C0522247 denotes ons for ne
T2628 1251-1256 UMLS/C0027552 denotes ds to
T2627 168-176 UMLS/C0680255 denotes released
T2626 2486-2491 UMLS/C1881122 denotes could
T2625 2928-2933 UMLS/C0243095 denotes that
T2624 274-282 UMLS/C1608518 denotes clinical
T2623 320-341 UP/P29553 denotes tumor necrosis factor
T2622 320-341 UP/P23563 denotes tumor necrosis factor
T2621 320-341 UP/Q8HZD9 denotes tumor necrosis factor
T2620 1471-1478 UMLS/C0684328 denotes sons: f
T2619 1287-1294 UMLS/C0700364 denotes ects. I
T2618 1762-1768 UMLS/C1749457 denotes ), whi
T2617 1287-1294 UMLS/C1547011 denotes ects. I
T2616 1862-1888 UP/P09056 denotes ia inhibitory factor by sy
T2615 1480-1485 UMLS/C1279901 denotes st, s
T2614 1862-1888 UP/P15018 denotes ia inhibitory factor by sy
T2613 2492-2497 UMLS/C0344312 denotes be an
T2612 1638-1641 UMLS/C0344312 denotes als
T2611 1383-1386 UMLS/C0344312 denotes in
T2610 1797-1804 UMLS/C1959609 denotes n in RA
T2609 1601-1613 UMLS/C0302523 denotes rvations dem
T2608 2666-2673 UMLS/C1279919 denotes r studi
T2607 1461-1464 UMLS/C0205448 denotes ma
T2606 2652-2662 UMLS/C1301746 denotes nted in ea
T2605 2957-2974 UMLS/C0037080 denotes ing pathway invol
T2604 3080-3083 UMLS/C1554080 denotes lam
T2603 404-407 UMLS/C1554080 denotes ey
T2602 2492-2497 UMLS/C0006823 denotes be an
T2601 1638-1641 UMLS/C0006823 denotes als
T2600 1383-1386 UMLS/C0006823 denotes in
T2599 1555-1561 UMLS/C0205436 denotes nd, it
T2598 1734-1741 UMLS/C0521447 denotes ear fac
T2597 1480-1485 UMLS/C0205435 denotes st, s
T2596 1934-1946 UMLS/C0028128 denotes oxide by ch
T2595 1305-1308 UMLS/C0205447 denotes of
T2594 823-829 UMLS/C1706309 denotes ints o
T2593 242-248 UMLS/C1706309 denotes joints
T2592 109-114 UMLS/C1706309 denotes joint
T2591 2868-2876 UMLS/C1550655 denotes ts with
T2590 2131-2139 UMLS/C1550655 denotes ts with
T2589 2106-2114 UMLS/C1550655 denotes ts with
T2588 845-855 UMLS/C1550652 denotes crophage a
T2587 76-87 UMLS/C1550652 denotes macrophages
T2586 669-679 UMLS/C1257890 denotes opulation
T2585 3012-3016 UMLS/C1705325 denotes Akt
T2584 320-341 UP/P23383 denotes tumor necrosis factor
T2583 881-890 UMLS/C1552866 denotes cluding I
T2582 1471-1478 UMLS/C0392360 denotes sons: f
T2581 680-692 UMLS/C1549537 denotes nfiltrating
T2580 1235-1239 UMLS/C1704326 denotes e of
T2579 997-1001 UMLS/C1704326 denotes e of
T2578 1950-1962 UMLS/C0225369 denotes ocytes, and
T2577 1411-1422 UMLS/C1550637 denotes roblasts [5
T2576 860-870 UMLS/C1550637 denotes broblast c
T2575 320-341 UP/Q1G1A2 denotes tumor necrosis factor
T2574 680-692 UMLS/C0332448 denotes nfiltrating
T2573 59-72 UMLS/C0332448 denotes infiltrations
T2572 1792-1796 UMLS/C0443157 denotes rosi
T2571 1862-1888 UP/P17777 denotes ia inhibitory factor by sy
T2570 2096-2102 UMLS/C1522410 denotes in pa
T2569 1862-1888 UMLS/C1761537 denotes ia inhibitory factor by sy
T2568 320-341 UP/Q8WNR1 denotes tumor necrosis factor
T2567 2061-2076 UMLS/C0039097 denotes al fluids were
T2566 2209-2217 UMLS/C0039099 denotes um [11,1
T2565 955-963 UMLS/C0039099 denotes ovium. T
T2564 697-705 UMLS/C0039099 denotes ynovium.
T2563 2652-2662 UMLS/C1547673 denotes nted in ea
T2562 793-797 UMLS/C1522405 denotes L-2
T2561 320-341 UMLS/C1456820 denotes tumor necrosis factor
T2560 2787-2794 UMLS/C0150312 denotes t study
T2559 320-341 UP/Q9BEA1 denotes tumor necrosis factor
T2558 498-510 UMLS/C2347934 denotes pplications
T2557 1555-1561 UMLS/C0565930 denotes nd, it
T2556 320-341 UP/Q19LH4 denotes tumor necrosis factor
T2555 42-55 UMLS/C1880022 denotes characterized
T2554 1403-1407 UMLS/C1366571 denotes 8 by
T2553 2795-2800 UMLS/C0557651 denotes we us
T2552 2674-2681 UMLS/C0557651 denotes s [12,1
T2551 728-735 UMLS/C0557651 denotes tudies
T2550 2566-2573 UMLS/C0039194 denotes s [14].
T2549 2194-2201 UMLS/C0039194 denotes s in th
T2548 1581-1588 UMLS/C0039194 denotes lls [6]
T2547 1368-1375 UMLS/C0039194 denotes ells, w
T2546 1243-1250 UMLS/C0039194 denotes ells ne
T2545 1128-1135 UMLS/C0039194 denotes ells, e
T2544 3018-3021 UP/Q8INB9 denotes d N
T2543 3214-3217 UMLS/C1553390 denotes rap
T2542 3147-3150 UMLS/C1553390 denotes igh
T2541 482-485 UMLS/C1553390 denotes ew
T2540 2643-2646 UMLS/C2348947 denotes en
T2539 1005-1012 UMLS/C0039194 denotes ells in
T2538 760-766 UMLS/C0039194 denotes cell-
T2537 2271-2274 UMLS/C2348947 denotes en
T2536 1968-1971 UMLS/C2348947 denotes e a
T2489 1601-1613 UMLS/C1554188 denotes rvations dem
T2488 2486-2491 UMLS/C1149233 denotes could
T2487 2828-2839 UMLS/C1292732 denotes igate IL-17
T2486 2227-2232 UMLS/C0254610 denotes secr
T2485 903-908 UMLS/C0254610 denotes -15,
T2484 1853-1857 UMLS/C1149241 denotes nd l
T2483 1394-1398 UMLS/C1149241 denotes 6 an
T2482 897-901 UMLS/C1149241 denotes -6,
T2481 1987-2000 UMLS/C0205615 denotes entiate and a
T2480 664-668 UMLS/C1136359 denotes ell
T2479 188-193 UMLS/C1136359 denotes cells
T2478 3133-3138 UMLS/C0454788 denotes rovid
T2477 3033-3038 UMLS/C0454788 denotes e inv
T2476 982-992 UMLS/C1522634 denotes stioned th
T2475 292-300 UMLS/C1706701 denotes obtained
T2474 320-341 UMLS/C2700093 denotes tumor necrosis factor
T2473 2412-2421 UMLS/C1550474 denotes ive pathw
T2472 283-291 UMLS/C0814225 denotes benefits
T2471 793-797 UMLS/C0879590 denotes L-2
T2470 498-510 UMLS/C0185125 denotes pplications
T2469 1913-1929 UMLS/C0012472 denotes glandin E2 and n
T2468 767-774 UMLS/C1711343 denotes erived
T2467 664-668 UMLS/C1948049 denotes ell
T2466 188-193 UMLS/C1948049 denotes cells
T2465 320-341 UP/Q2MH05 denotes tumor necrosis factor
T2464 306-316 UMLS/C1999216 denotes inhibitors
T2463 320-341 UMLS/C0041368 denotes tumor necrosis factor
T2462 2005-2013 UMLS/C1879547 denotes te the d
T2461 1647-1655 UMLS/C1879547 denotes vate ost
T2460 1358-1367 UMLS/C1879547 denotes ivated T
T2459 1085-1093 UMLS/C1999177 denotes anced pr
T2458 320-341 UP/Q539C2 denotes tumor necrosis factor
T2457 3125-3132 UMLS/C1280519 denotes might
T2456 2795-2800 UMLS/C0008972 denotes we us
T2455 2674-2681 UMLS/C0008972 denotes s [12,1
T2454 728-735 UMLS/C0008972 denotes tudies
T2453 13-33 UMLS/C0003873 denotes Rheumatoid arthritis
T2452 1976-1983 UMLS/C0085732 denotes y to di
T2451 2795-2800 UMLS/C0008976 denotes we us
T2450 2674-2681 UMLS/C0008976 denotes s [12,1
T2449 728-735 UMLS/C0008976 denotes tudies
T2448 3218-3229 UMLS/C1553525 denotes utic strate
T2447 486-497 UMLS/C1553525 denotes herapeutic
T2446 1808-1813 UMLS/C0072944 denotes . It
T2445 2618-2636 UMLS/C0003864 denotes inflammation in RA
T2444 2227-2232 UMLS/C1334105 denotes secr
T2443 903-908 UMLS/C1334105 denotes -15,
T2442 227-238 UMLS/C1948029 denotes destruction
T2441 1853-1857 UMLS/C1527132 denotes nd l
T2371 3106-3111 UMLS/C0384648 denotes n RA.
T2440 1394-1398 UMLS/C1527132 denotes 6 an
T2439 897-901 UMLS/C1527132 denotes -6,
T2438 292-300 UMLS/C1301820 denotes obtained
T2437 168-176 UMLS/C1963578 denotes released
T2436 910-915 UMLS/C1334109 denotes -18 a
T2435 467-478 UMLS/C1527148 denotes evelopment
T2434 845-855 UMLS/C1546706 denotes crophage a
T2433 76-87 UMLS/C1546706 denotes macrophages
T2432 718-724 UMLS/C0205549 denotes eries
T2431 910-915 UMLS/C1527127 denotes -18 a
T2430 1824-1834 UMLS/C1948023 denotes ates the p
T2429 2018-2033 UMLS/C0011306 denotes tic cells [8-10
T2428 320-341 UP/P04924 denotes tumor necrosis factor
T2427 320-341 UP/P01375 denotes tumor necrosis factor
T2426 1403-1407 UMLS/C1149173 denotes 8 by
T2425 2652-2662 UMLS/C1548385 denotes nted in ea
T2424 2795-2800 UMLS/C2603343 denotes we us
T2423 2674-2681 UMLS/C2603343 denotes s [12,1
T2422 728-735 UMLS/C2603343 denotes tudies
T2421 1669-1684 UMLS/C0005974 denotes resorption by
T2420 320-341 UP/P16599 denotes tumor necrosis factor
T2419 1085-1093 UMLS/C2349975 denotes anced pr
T2418 3097-3105 UMLS/C1524094 denotes e IL-17
T2417 1433-1441 UMLS/C1524094 denotes okine is
T2416 1329-1338 UMLS/C1524094 denotes okines se
T2415 1210-1219 UMLS/C1524094 denotes okines in
T2414 871-880 UMLS/C1524094 denotes tokines i
T2413 775-784 UMLS/C1524094 denotes ytokines
T2412 421-430 UMLS/C1524094 denotes ytokines
T2411 158-167 UMLS/C1524094 denotes cytokines
T2410 3012-3016 UP/P42336 denotes Akt
T2409 2795-2800 UMLS/C2349977 denotes we us
T2408 2674-2681 UMLS/C2349977 denotes s [12,1
T2407 728-735 UMLS/C2349977 denotes tudies
T2406 2096-2102 UMLS/C1561957 denotes in pa
T2405 3214-3217 UMLS/C1578513 denotes rap
T2404 3147-3150 UMLS/C1578513 denotes igh
T2403 482-485 UMLS/C1578513 denotes ew
T2402 2096-2102 UMLS/C1561958 denotes in pa
T2401 1853-1857 UMLS/C0021760 denotes nd l
T2400 1394-1398 UMLS/C0021760 denotes 6 an
T2399 897-901 UMLS/C0021760 denotes -6,
T2398 680-692 UMLS/C1546677 denotes nfiltrating
T2397 1555-1561 UMLS/C0457385 denotes nd, it
T2396 1705-1710 UMLS/C1367028 denotes L (re
T2395 356-367 UMLS/C0021764 denotes nterleukin
T2394 3106-3111 UMLS/C1522571 denotes n RA.
T2393 2609-2614 UMLS/C1522571 denotes in jo
T2392 2052-2057 UMLS/C1522571 denotes in sy
T2391 1632-1637 UMLS/C1522571 denotes 7 can
T2390 1517-1522 UMLS/C1522571 denotes 7 has
T2389 1296-1301 UMLS/C1522571 denotes 17 is
T2388 2868-2876 UMLS/C0030705 denotes ts with
T2387 2131-2139 UMLS/C0030705 denotes ts with
T2386 2106-2114 UMLS/C0030705 denotes ts with
T2385 1853-1857 UMLS/C1334122 denotes nd l
T2384 1394-1398 UMLS/C1334122 denotes 6 an
T2383 897-901 UMLS/C1334122 denotes -6,
T2382 3080-3083 UMLS/C1706198 denotes lam
T2381 404-407 UMLS/C1706198 denotes ey
T2380 1511-1515 UMLS/C0021755 denotes , IL
T2379 891-895 UMLS/C0021755 denotes -1,
T2378 1511-1515 UMLS/C0021753 denotes , IL
T2377 891-895 UMLS/C0021753 denotes -1,
T2376 793-797 UMLS/C0021756 denotes L-2
T2375 2943-2956 UMLS/C0175996 denotes ellular signa
T2374 2698-2711 UMLS/C0175996 denotes ellular signa
T2373 2975-2984 UMLS/C1314939 denotes ing phosp
T2372 320-341 UP/P51743 denotes tumor necrosis factor
T2370 2609-2614 UMLS/C0384648 denotes in jo
T2369 1780-1788 UMLS/C1314939 denotes ed in bo
T2368 2052-2057 UMLS/C0384648 denotes in sy
T2367 1632-1637 UMLS/C0384648 denotes 7 can
T2366 1517-1522 UMLS/C0384648 denotes 7 has
T2365 2868-2876 UMLS/C1578479 denotes ts with
T2364 1296-1301 UMLS/C0384648 denotes 17 is
T2363 3042-3050 UMLS/C1314939 denotes d in the
T2362 2131-2139 UMLS/C1578479 denotes ts with
T2361 2106-2114 UMLS/C1578479 denotes ts with
T2360 3012-3016 UMLS/C1368105 denotes Akt
T2359 664-668 UMLS/C1704653 denotes ell
T2358 188-193 UMLS/C1704653 denotes cells
T2357 2868-2876 UMLS/C1578483 denotes ts with
T2356 2131-2139 UMLS/C1578483 denotes ts with
T2355 2106-2114 UMLS/C1578483 denotes ts with
T2354 2868-2876 UMLS/C1578480 denotes ts with
T2353 2131-2139 UMLS/C1578480 denotes ts with
T2352 2106-2114 UMLS/C1578480 denotes ts with
T2351 2868-2876 UMLS/C1578481 denotes ts with
T2350 2131-2139 UMLS/C1578481 denotes ts with
T2349 2106-2114 UMLS/C1578481 denotes ts with
T2348 2868-2876 UMLS/C1578486 denotes ts with
T2347 2131-2139 UMLS/C1578486 denotes ts with
T2346 2106-2114 UMLS/C1578486 denotes ts with
T2345 392-400 UMLS/C0332206 denotes lockade
T2344 2868-2876 UMLS/C1578484 denotes ts with
T2343 2131-2139 UMLS/C1578484 denotes ts with
T2342 2106-2114 UMLS/C1578484 denotes ts with
T2341 1797-1804 UMLS/C0333307 denotes n in RA
T2340 2868-2876 UMLS/C1578485 denotes ts with
T2339 2131-2139 UMLS/C1578485 denotes ts with
T2338 2106-2114 UMLS/C1578485 denotes ts with
T2337 525-529 UMLS/C0205136 denotes ver
T2336 1892-1904 UMLS/C0224522 denotes ocytes, and
T2335 320-341 UMLS/C1323304 denotes tumor necrosis factor
T2334 227-238 UMLS/C1261381 denotes destruction
T2333 356-367 UMLS/C1527200 denotes nterleukin
T2332 320-341 UP/O77510 denotes tumor necrosis factor
T2331 823-829 UMLS/C0392905 denotes ints o
T2330 242-248 UMLS/C0392905 denotes joints
T2329 109-114 UMLS/C0392905 denotes joint
T2328 320-341 UP/Q75N23 denotes tumor necrosis factor
T2327 823-829 UMLS/C1269611 denotes ints o
T2326 242-248 UMLS/C1269611 denotes joints
T2325 109-114 UMLS/C1269611 denotes joint
T2324 306-316 UMLS/C0243077 denotes inhibitors
T2323 2957-2974 UMLS/C0086982 denotes ing pathway invol
T2322 2893-2923 UMLS/C0086982 denotes ing transduction pathway. We f
T2321 2712-2739 UMLS/C0086982 denotes transduction pathway for I
T2320 2437-2445 UMLS/C0332185 denotes ly, Happ
T2319 1594-1600 UMLS/C0332185 denotes nt obs
T2318 1862-1888 UMLS/C0125606 denotes ia inhibitory factor by sy
T2317 1465-1470 UMLS/C0205164 denotes or re
T2316 3042-3050 UMLS/C1947935 denotes d in the
T2315 2975-2984 UMLS/C1947935 denotes ing phosp
T2314 1780-1788 UMLS/C1947935 denotes ed in bo
T2313 1862-1888 UP/Q27956 denotes ia inhibitory factor by sy
T2312 1543-1553 UMLS/C2347695 denotes erties; se
T2311 3106-3111 UMLS/C1623218 denotes n RA.
T2310 2609-2614 UMLS/C1623218 denotes in jo
T2309 2052-2057 UMLS/C1623218 denotes in sy
T2308 1632-1637 UMLS/C1623218 denotes 7 can
T2307 1517-1522 UMLS/C1623218 denotes 7 has
T2306 1296-1301 UMLS/C1623218 denotes 17 is
T2305 1762-1768 UMLS/C0023688 denotes ), whi
T2304 1601-1613 UMLS/C1548358 denotes rvations dem
T2303 2795-2800 UMLS/C1880229 denotes we us
T2302 2674-2681 UMLS/C1880229 denotes s [12,1
T2301 728-735 UMLS/C1880229 denotes tudies
T2300 1403-1407 UMLS/C1705592 denotes 8 by
T2299 2985-3001 UMLS/C0031621 denotes oinositide 3-kin
T2298 664-668 UMLS/C1269647 denotes ell
T2297 188-193 UMLS/C1269647 denotes cells
T2296 1862-1888 UP/O62728 denotes ia inhibitory factor by sy
T2295 498-510 UMLS/C1947919 denotes pplications
T2294 982-992 UMLS/C0332147 denotes stioned th
T2293 910-915 UMLS/C0383327 denotes -18 a
T2292 2486-2491 UMLS/C0963088 denotes could
T2291 1601-1613 UMLS/C0557985 denotes rvations dem
T2290 1287-1294 UMLS/C1879746 denotes ects. I
T2289 3199-3209 UMLS/C0700158 denotes ons for ne
T2288 1601-1613 UMLS/C1964257 denotes rvations dem
T2287 2817-2824 UMLS/C0234402 denotes i to in
T2286 168-176 UMLS/C1283071 denotes released
T2285 1094-1107 UMLS/C0334094 denotes liferation of
T2284 3218-3229 UMLS/C0039796 denotes utic strate
T2283 486-497 UMLS/C0039796 denotes herapeutic
T2282 320-341 UMLS/C1522668 denotes tumor necrosis factor
T2281 375-382 UMLS/C1705535 denotes uggest
T2280 1555-1561 UMLS/C1705190 denotes nd, it
T2279 3012-3016 UMLS/C0285761 denotes Akt
T2278 2825-2827 UMLS/C0319022 denotes es
T2277 2289-2291 UMLS/C0319022 denotes an
T2276 1984-1986 UMLS/C0319022 denotes fe
T2275 1497-1499 UMLS/C0319022 denotes TN
T2274 1257-1259 UMLS/C0319022 denotes be
T2535 1523-1526 UMLS/C2348947 denotes pro
T2534 978-981 UMLS/C2348947 denotes qu
T2533 431-434 UMLS/C2348947 denotes as
T2532 2943-2956 UMLS/C0178719 denotes ellular signa
T2531 559-566 UMLS/C0039194 denotes cells
T2530 2698-2711 UMLS/C0178719 denotes ellular signa
T2529 2504-2513 UMLS/C0442799 denotes ent trigg
T2528 92-99 UMLS/C0039194 denotes T cells
T2527 2234-2242 UMLS/C1327616 denotes ed from
T2526 1339-1347 UMLS/C1327616 denotes reted ma
T2525 1235-1239 UMLS/C1705809 denotes e of
T2524 997-1001 UMLS/C1705809 denotes e of
T2523 1119-1127 UMLS/C0205369 denotes cific T
T2522 3199-3209 UMLS/C1550715 denotes ons for ne
T2521 1235-1239 UMLS/C1705812 denotes e of
T2520 997-1001 UMLS/C1705812 denotes e of
T2519 1235-1239 UMLS/C1705810 denotes e of
T2518 997-1001 UMLS/C1705810 denotes e of
T2517 1543-1553 UMLS/C1704391 denotes erties; se
T2516 1235-1239 UMLS/C1705811 denotes e of
T2515 997-1001 UMLS/C1705811 denotes e of
T2514 1511-1515 UMLS/C1522428 denotes , IL
T2513 891-895 UMLS/C1522428 denotes -1,
T2512 2042-2048 UMLS/C0456079 denotes of IL
T2511 3230-3240 UMLS/C0679199 denotes ies in RA.
T2510 823-829 UMLS/C0022417 denotes ints o
T2509 242-248 UMLS/C0022417 denotes joints
T2508 109-114 UMLS/C0022417 denotes joint
T2507 1277-1286 UMLS/C1705242 denotes ferent as
T2506 1797-1804 UMLS/C1880549 denotes n in RA
T2505 320-341 UP/P06804 denotes tumor necrosis factor
T2504 2652-2662 UMLS/C1301725 denotes nted in ea
T2503 1511-1515 UMLS/C1149212 denotes , IL
T2502 891-895 UMLS/C1149212 denotes -1,
T2501 3199-3209 UMLS/C0449738 denotes ons for ne
T2500 2652-2662 UMLS/C1609436 denotes nted in ea
T2499 498-510 UMLS/C1547755 denotes pplications
T2498 2227-2232 UMLS/C1149222 denotes secr
T2497 903-908 UMLS/C1149222 denotes -15,
T2496 2769-2778 UMLS/C0087130 denotes ain. In t
T2495 1235-1239 UMLS/C0035820 denotes e of
T2494 997-1001 UMLS/C0035820 denotes e of
T2493 320-341 UP/Q1WM27 denotes tumor necrosis factor
T2492 2042-2048 UMLS/C0441889 denotes of IL
T2491 910-915 UMLS/C1149225 denotes -18 a
T2490 793-797 UMLS/C1149229 denotes L-2
T2273 1148-1150 UMLS/C0319022 denotes ty
T2272 204-206 UMLS/C0319022 denotes to
T2271 669-679 UMLS/C0032659 denotes opulation
T2270 3139-3146 UMLS/C0359589 denotes new in
T2269 932-940 UMLS/C2346714 denotes ndant in
T2268 2280-2288 UMLS/C1709908 denotes ed to be
T2267 1555-1561 UMLS/C2348168 denotes nd, it
T2266 59-72 UMLS/C0702249 denotes infiltrations
T2265 498-510 UMLS/C1533134 denotes pplications
T2264 1601-1613 UMLS/C0941132 denotes rvations dem
T2263 1705-1710 UMLS/C0666364 denotes L (re
T2262 3084-3096 UMLS/C0333348 denotes atory cytoki
T2261 1316-1328 UMLS/C0333348 denotes lammatory cy
T2260 408-420 UMLS/C0333348 denotes nflammatory
T2259 2652-2662 UMLS/C1563337 denotes nted in ea
T2258 320-341 UP/P51742 denotes tumor necrosis factor
T2257 2795-2800 UMLS/C0947630 denotes we us
T2256 2674-2681 UMLS/C0947630 denotes s [12,1
T2255 728-735 UMLS/C0947630 denotes tudies
T2254 1555-1561 UMLS/C1561503 denotes nd, it
T2253 3218-3229 UMLS/C1547427 denotes utic strate
T2252 486-497 UMLS/C1547427 denotes herapeutic
T2251 1712-1720 UMLS/C0597357 denotes ptor act
T2250 59-72 UMLS/C1523986 denotes infiltrations
T2249 168-176 UMLS/C0391871 denotes released
T2248 3097-3105 UMLS/C0079189 denotes e IL-17
T2247 1433-1441 UMLS/C0079189 denotes okine is
T2246 1329-1338 UMLS/C0079189 denotes okines se
T2245 1210-1219 UMLS/C0079189 denotes okines in
T2244 871-880 UMLS/C0079189 denotes tokines i
T2243 775-784 UMLS/C0079189 denotes ytokines
T2242 421-430 UMLS/C0079189 denotes ytokines
T2241 158-167 UMLS/C0079189 denotes cytokines
T2240 2514-2521 UMLS/C1444748 denotes r of IL
T2239 2308-2315 UMLS/C1444748 denotes r of IL
T2238 2387-2399 UMLS/C0010592 denotes porine and s
T2237 2387-2399 UMLS/C0010594 denotes porine and s
T2236 320-341 UP/P48094 denotes tumor necrosis factor
T2235 656-663 UMLS/C0549177 denotes argest

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T3461 3237-3239 NN denotes RA
T3460 3234-3236 IN denotes in
T3459 3223-3233 NN denotes strategies
T3458 3211-3222 JJ denotes therapeutic
T3457 3207-3210 JJ denotes new
T3456 3203-3206 IN denotes for
T3455 3192-3202 NN denotes directions
T3454 3185-3191 JJ denotes future
T3453 3181-3184 CC denotes and
T3452 3178-3180 NN denotes RA
T3451 3175-3177 IN denotes of
T3450 3162-3174 NN denotes pathogenesis
T3449 3158-3161 DT denotes the
T3448 3153-3157 IN denotes into
T3447 3144-3152 NN denotes insights
T3446 3140-3143 JJ denotes new
T3445 3132-3139 VB denotes provide
T3444 3126-3131 MD denotes might
T3443 3118-3125 NN denotes results
T3442 3112-3117 DT denotes These
T3441 3108-3110 NN denotes RA
T3440 3105-3107 IN denotes in
T3439 3099-3104 NN denotes IL-17
T3438 3090-3098 NN denotes cytokine
T3437 3077-3089 JJ denotes inflammatory
T3436 3073-3076 JJ denotes key
T3435 3069-3072 DT denotes the
T3434 3066-3068 IN denotes of
T3433 3051-3065 NN denotes overproduction
T3432 3047-3050 DT denotes the
T3431 3044-3046 IN denotes in
T3430 3035-3043 VB denotes involved
T3429 3032-3034 VB denotes be
T3428 3026-3031 MD denotes might
T3427 3020-3025 NN denotes NF-κB
T3426 3016-3019 CC denotes and
T3425 3011-3015 NN denotes /Akt
T3424 3010-3011 -RRB- denotes )
T3423 3006-3010 NN denotes PI3K
T3422 3005-3006 -LRB- denotes (
T3421 2996-3004 NN denotes 3-kinase
T3420 2979-2995 NN denotes phosphoinositide
T3419 2969-2978 VB denotes involving
T3418 2961-2968 NN denotes pathway
T3417 2951-2960 NN denotes signaling
T3416 2937-2950 JJ denotes intracellular
T3415 2933-2936 DT denotes the
T3414 2928-2932 IN denotes that
T3413 2922-2927 VB denotes found
T3412 2919-2921 PRP denotes We
T3411 2910-2917 NN denotes pathway
T3410 2897-2909 NN denotes transduction
T3409 2887-2896 NN denotes signaling
T3408 2883-2886 PRP-DOLLAR- denotes its
T3407 2879-2882 CC denotes and
T3406 2876-2878 NN denotes RA
T3405 2871-2875 IN denotes with
T3404 2862-2870 NN denotes patients
T3403 2859-2861 IN denotes of
T3402 2854-2858 NN denotes PBMC
T3401 2851-2853 IN denotes in
T3400 2840-2850 NN denotes production
T3399 2834-2839 NN denotes IL-17
T3397 2819-2821 TO denotes to
T3396 2811-2818 NN denotes stimuli
T3395 2803-2810 JJ denotes various
T3394 2798-2802 VB denotes used
T3393 2795-2797 PRP denotes we
T3392 2789-2794 NN denotes study
T3391 2781-2788 JJ denotes present
T3390 2777-2780 DT denotes the
T3389 2774-2776 IN denotes In
T3388 2763-2772 JJ denotes uncertain
T3387 2755-2762 VB denotes remains
T3386 2744-2754 NN denotes production
T3385 2738-2743 NN denotes IL-17
T3384 2734-2737 IN denotes for
T3383 2726-2733 NN denotes pathway
T3382 2713-2725 NN denotes transduction
T3381 2706-2712 NN denotes signal
T3380 2692-2705 JJ denotes intracellular
T3379 2688-2691 DT denotes the
T3378 2686-2687 -COMMA- denotes ,
T3377 2685-2686 -RRB- denotes ]
T3376 2677-2685 CD denotes 12,15,16
T3375 2676-2677 -LRB- denotes [
T3374 2668-2675 NN denotes studies
T3373 2660-2667 JJ denotes earlier
T3372 2657-2659 IN denotes in
T3371 2646-2656 VB denotes documented
T3370 2641-2645 VB denotes been
T3369 2637-2640 VB denotes has
T3368 2634-2636 NN denotes RA
T3367 2631-2633 IN denotes in
T3366 2618-2630 NN denotes inflammation
T3365 2612-2617 JJ denotes joint
T3364 2609-2611 IN denotes in
T3363 2603-2608 NN denotes IL-17
T3362 2600-2602 IN denotes of
T3361 2587-2599 NN denotes contribution
T3360 2583-2586 DT denotes the
T3359 2574-2582 IN denotes Although
T3358 2571-2572 -RRB- denotes ]
T3357 2569-2571 CD denotes 14
T3356 2568-2569 -LRB- denotes [
T3355 2562-2567 NN denotes cells
T3354 2560-2561 NN denotes T
T3353 2555-2559 JJ denotes CD8+
T3352 2551-2554 CC denotes and
T3351 2546-2550 JJ denotes CD4+
T3350 2541-2545 CC denotes both
T3349 2536-2540 IN denotes from
T3348 2525-2535 NN denotes production
T3347 2519-2524 NN denotes IL-17
T3346 2516-2518 IN denotes of
T3345 2508-2515 NN denotes trigger
T3344 2498-2507 JJ denotes efficient
T3343 2495-2497 DT denotes an
T3342 2492-2494 VB denotes be
T3341 2486-2491 MD denotes could
T3340 2480-2485 NN denotes IL-23
T3339 2475-2479 IN denotes that
T3338 2468-2474 VB denotes showed
T3337 2463-2467 RB denotes also
T3336 2452-2462 NN denotes colleagues
T3335 2448-2451 CC denotes and
T3334 2441-2447 NNP denotes Happel
T3333 2439-2440 -COMMA- denotes ,
T3332 2431-2439 RB denotes Recently
T3331 2428-2429 -RRB- denotes ]
T3330 2426-2428 CD denotes 13
T3329 2425-2426 -LRB- denotes [
T3328 2416-2424 NN denotes pathways
T3327 2406-2415 JJ denotes sensitive
T3326 2398-2405 NN denotes steroid
T3325 2394-2397 CC denotes and
T3324 2381-2393 NN denotes cyclosporine
T3323 2378-2380 IN denotes by
T3322 2376-2377 -RRB- denotes )
T3321 2372-2376 NN denotes PBMC
T3320 2371-2372 -LRB- denotes (
T3319 2365-2370 NN denotes cells
T3318 2353-2364 JJ denotes mononuclear
T3317 2347-2352 NN denotes blood
T3316 2336-2346 JJ denotes peripheral
T3315 2333-2335 NN denotes RA
T3314 2330-2332 IN denotes in
T3313 2319-2329 NN denotes production
T3312 2313-2318 NN denotes IL-17
T3311 2310-2312 IN denotes of
T3310 2302-2309 NN denotes trigger
T3309 2292-2301 JJ denotes important
T3308 2289-2291 DT denotes an
T3307 2286-2288 VB denotes be
T3306 2283-2285 TO denotes to
T3305 2274-2282 VB denotes reported
T3304 2269-2273 VB denotes been
T3303 2265-2268 VB denotes has
T3302 2263-2264 -COMMA- denotes ,
T3301 2252-2263 NN denotes macrophages
T3300 2242-2251 VB denotes activated
T3299 2237-2241 IN denotes from
T3298 2228-2236 VB denotes secreted
T3297 2226-2227 -COMMA- denotes ,
T3296 2221-2226 NN denotes IL-15
T3295 2218-2219 -RRB- denotes ]
T3294 2213-2218 CD denotes 11,12
T3293 2212-2213 -LRB- denotes [
T3292 2203-2211 NN denotes synovium
T3291 2199-2202 DT denotes the
T3290 2196-2198 IN denotes in
T3289 2190-2195 NN denotes cells
T3288 2188-2189 NN denotes T
T3287 2183-2187 JJ denotes CD4+
T3286 2180-2182 IN denotes by
T3285 2171-2179 VB denotes produced
T3284 2167-2170 VB denotes was
T3283 2164-2166 PRP denotes it
T3282 2160-2163 CC denotes and
T3281 2158-2159 -COMMA- denotes ,
T3280 2157-2158 -RRB- denotes )
T3279 2155-2157 NN denotes OA
T3278 2154-2155 -LRB- denotes (
T3277 2139-2153 NN denotes osteoarthritis
T3276 2134-2138 IN denotes with
T3275 2125-2133 NN denotes patients
T3274 2122-2124 IN denotes in
T3273 2117-2121 IN denotes than
T3272 2114-2116 NN denotes RA
T3271 2109-2113 IN denotes with
T3270 2100-2108 NN denotes patients
T3269 2097-2099 IN denotes in
T3258 2029-2033 CD denotes 8-10
T3257 2028-2029 -LRB- denotes [
T3256 2022-2027 NN denotes cells
T3255 2012-2021 JJ denotes dendritic
T3254 2008-2011 DT denotes the
T3253 1999-2007 VB denotes activate
T3252 1995-1998 CC denotes and
T3251 1981-1994 VB denotes differentiate
T3250 1978-1980 TO denotes to
T3249 1970-1977 NN denotes ability
T3248 1966-1969 DT denotes the
T3247 1962-1965 VB denotes has
T3246 1958-1961 CC denotes and
T3245 1956-1957 -COMMA- denotes ,
T3244 1944-1956 NN denotes chondrocytes
T3243 1941-1943 IN denotes by
T3242 1935-1940 NN denotes oxide
T3241 1928-1934 JJ denotes nitric
T3240 1924-1927 CC denotes and
T3239 1921-1923 NN denotes E2
T3238 1907-1920 NN denotes prostaglandin
T3237 1904-1906 IN denotes of
T3236 1900-1903 CC denotes and
T3235 1898-1899 -COMMA- denotes ,
T3234 1886-1898 NN denotes synoviocytes
T3233 1883-1885 IN denotes by
T3232 1876-1882 NN denotes factor
T3231 1865-1875 JJ denotes inhibitory
T3230 1856-1864 NN denotes leukemia
T3229 1852-1855 CC denotes and
T3228 1847-1851 NN denotes IL-6
T3227 1844-1846 IN denotes of
T3226 1833-1843 NN denotes production
T3225 1829-1832 DT denotes the
T3224 1818-1828 VB denotes stimulates
T3223 1813-1817 RB denotes also
T3222 1810-1812 PRP denotes It
T3221 1807-1808 -RRB- denotes ]
T3220 1806-1807 CD denotes 7
T3219 1805-1806 -LRB- denotes [
T3218 1802-1804 NN denotes RA
T3217 1799-1801 IN denotes in
T3216 1791-1798 NN denotes erosion
T3215 1786-1790 JJ denotes bony
T3214 1783-1785 IN denotes in
T3213 1774-1782 VB denotes involved
T3212 1771-1773 VB denotes is
T3211 1765-1770 WDT denotes which
T3210 1763-1764 -COMMA- denotes ,
T3209 1762-1763 -RRB- denotes )
T3208 1756-1762 NN denotes ligand
T3207 1754-1755 -RRB- denotes ]
T3206 1749-1754 NN denotes NF-κB
T3205 1748-1749 -LRB- denotes [
T3204 1745-1747 NN denotes κB
T3203 1738-1744 NN denotes factor
T3202 1730-1737 JJ denotes nuclear
T3201 1727-1729 IN denotes of
T3200 1717-1726 NN denotes activator
T3199 1708-1716 NN denotes receptor
T3198 1707-1708 -LRB- denotes (
T3197 1701-1706 NN denotes RANKL
T3196 1698-1700 IN denotes of
T3195 1688-1697 NN denotes induction
T3194 1684-1687 DT denotes the
T3193 1681-1683 IN denotes by
T3192 1670-1680 NN denotes resorption
T3191 1665-1669 NN denotes bone
T3190 1652-1664 JJ denotes osteoclastic
T3189 1643-1651 VB denotes activate
T3188 1638-1642 RB denotes also
T3187 1634-1637 MD denotes can
T3186 1628-1633 NN denotes IL-17
T3185 1623-1627 IN denotes that
T3184 1610-1622 VB denotes demonstrated
T3183 1597-1609 NN denotes observations
T3182 1590-1596 JJ denotes Recent
T3181 1587-1588 -RRB- denotes ]
T3180 1586-1587 CD denotes 6
T3179 1585-1586 -LRB- denotes [
T3178 1579-1584 NN denotes cells
T3177 1577-1578 NN denotes T
T3176 1574-1576 IN denotes by
T3175 1565-1573 VB denotes produced
T3174 1562-1564 VB denotes is
T3173 1559-1561 PRP denotes it
T3172 1557-1558 -COMMA- denotes ,
T3171 1551-1557 RB denotes second
T3170 1549-1550 -COLON- denotes ;
T3169 1539-1549 NN denotes properties
T3168 1523-1538 JJ denotes proinflammatory
T3167 1519-1522 VB denotes has
T3166 1513-1518 NN denotes IL-17
T3165 1511-1512 -COMMA- denotes ,
T3164 1507-1511 NN denotes IL-1
T3163 1503-1506 CC denotes and
T3162 1497-1502 NN denotes TNF-α
T3161 1494-1496 TO denotes to
T3160 1484-1493 RB denotes similarly
T3159 1482-1483 -COMMA- denotes ,
T3158 1477-1482 RB denotes first
T3157 1475-1476 -COLON- denotes :
T3156 1468-1475 NN denotes reasons
T3155 1462-1467 JJ denotes major
T3154 1458-1461 CD denotes two
T3153 1454-1457 IN denotes for
T3152 1445-1453 NN denotes interest
T3151 1442-1444 IN denotes of
T3150 1439-1441 VB denotes is
T3149 1430-1438 NN denotes cytokine
T3148 1425-1429 DT denotes This
T3147 1422-1423 -RRB- denotes ]
T3146 1421-1422 CD denotes 5
T3145 1420-1421 -LRB- denotes [
T3144 1408-1419 NN denotes fibroblasts
T3143 1405-1407 IN denotes by
T3142 1400-1404 NN denotes IL-8
T3141 1396-1399 CC denotes and
T3140 1391-1395 NN denotes IL-6
T3139 1384-1390 VB denotes induce
T3138 1380-1383 MD denotes can
T3137 1374-1379 WDT denotes which
T3136 1372-1373 -COMMA- denotes ,
T3135 1367-1372 NN denotes cells
T3134 1365-1366 NN denotes T
T3133 1355-1364 VB denotes activated
T3132 1352-1354 IN denotes by
T3131 1345-1351 RB denotes mainly
T3130 1336-1344 VB denotes secreted
T3129 1326-1335 NN denotes cytokines
T3128 1313-1325 JJ denotes inflammatory
T3127 1309-1312 DT denotes the
T3126 1306-1308 IN denotes of
T3125 1302-1305 CD denotes one
T3124 1299-1301 VB denotes is
T3123 1293-1298 NN denotes IL-17
T3122 1284-1291 NN denotes aspects
T3121 1274-1283 JJ denotes different
T3120 1271-1273 IN denotes in
T3119 1260-1270 VB denotes elucidated
T3118 1257-1259 VB denotes be
T3117 1254-1256 TO denotes to
T3116 1248-1253 VB denotes needs
T3115 1242-1247 NN denotes cells
T3114 1240-1241 NN denotes T
T3113 1237-1239 IN denotes of
T3112 1232-1236 NN denotes role
T3111 1228-1231 DT denotes the
T3110 1226-1227 -COMMA- denotes ,
T3109 1225-1226 -RRB- denotes ]
T3108 1224-1225 CD denotes 4
T3107 1223-1224 -LRB- denotes [
T3106 1220-1222 NN denotes RA
T3105 1217-1219 IN denotes in
T3104 1207-1216 NN denotes cytokines
T3103 1205-1206 -RRB- denotes )
T3102 1202-1205 NN denotes Th1
T3101 1201-1202 -LRB- denotes (
T3100 1199-1200 CD denotes 1
T3099 1194-1198 NN denotes type
T3098 1187-1193 NN denotes helper
T3097 1185-1186 NN denotes T
T3096 1182-1184 IN denotes of
T3095 1174-1181 NN denotes skewing
T3094 1170-1173 DT denotes the
T3093 1166-1169 CC denotes and
T3092 1164-1165 -COMMA- denotes ,
T3091 1156-1164 NN denotes collagen
T3090 1153-1155 CD denotes II
T3089 1148-1152 NN denotes type
T3088 1145-1147 TO denotes to
T3087 1134-1144 RB denotes especially
T3086 1132-1133 -COMMA- denotes ,
T3085 1127-1132 NN denotes cells
T3084 1125-1126 NN denotes T
T3083 1116-1124 JJ denotes specific
T3082 1108-1115 NN denotes antigen
T3081 1105-1107 IN denotes of
T3080 1091-1104 NN denotes proliferation
T3079 1082-1090 VB denotes enhanced
T3078 1078-1081 DT denotes the
T3077 1065-1077 VB denotes demonstrated
T3076 1057-1064 RB denotes already
T3075 1052-1056 VB denotes have
T3074 1049-1051 PRP denotes we
T3073 1041-1048 IN denotes Because
T3072 1038-1039 -RRB- denotes ]
T3071 1037-1038 CD denotes 3
T3070 1036-1037 -LRB- denotes [
T3069 1033-1035 NN denotes RA
T3068 1030-1032 IN denotes of
T3067 1017-1029 NN denotes pathogenesis
T3066 1013-1016 DT denotes the
T3065 1010-1012 IN denotes in
T3064 1004-1009 NN denotes cells
T3063 1002-1003 NN denotes T
T3062 999-1001 IN denotes of
T3061 994-998 NN denotes role
T3060 990-993 DT denotes the
T3059 979-989 VB denotes questioned
T3058 975-978 VB denotes has
T3057 967-974 NN denotes paradox
T3056 962-966 DT denotes This
T3055 952-960 NN denotes synovium
T3054 941-951 JJ denotes rheumatoid
T3053 938-940 IN denotes in
T3052 929-937 JJ denotes abundant
T3051 924-928 VB denotes were
T3050 918-923 NN denotes TNF-α
T3049 914-917 CC denotes and
T3048 908-913 NN denotes IL-18
T3047 906-907 -COMMA- denotes ,
T3046 901-906 NN denotes IL-15
T3045 899-900 -COMMA- denotes ,
T3044 895-899 NN denotes IL-6
T3043 893-894 -COMMA- denotes ,
T3022 759-760 NN denotes T
T3021 756-758 IN denotes of
T3020 748-755 NN denotes paucity
T3019 735-747 VB denotes demonstrated
T3018 727-734 NN denotes studies
T3017 724-726 IN denotes of
T3016 717-723 NN denotes series
T3015 715-716 DT denotes a
T3014 713-714 -COMMA- denotes ,
T3013 706-713 RB denotes However
T3012 696-704 NN denotes synovium
T3011 692-695 DT denotes the
T3010 679-691 VB denotes infiltrating
T3009 668-678 NN denotes population
T3008 663-667 NN denotes cell
T3007 655-662 JJ denotes largest
T3006 651-654 DT denotes the
T3005 647-650 VB denotes are
T3004 642-646 PRP denotes they
T3003 634-641 IN denotes because
T3002 623-633 JJ denotes undisputed
T3001 619-622 VB denotes was
T3000 616-618 NN denotes RA
T2999 613-615 IN denotes as
T2998 608-612 JJ denotes such
T2997 600-607 NN denotes disease
T2996 589-599 JJ denotes autoimmune
T2995 586-588 IN denotes of
T2994 573-585 NN denotes pathogenesis
T2993 569-572 DT denotes the
T2992 566-568 IN denotes in
T2991 560-565 NN denotes cells
T2990 558-559 NN denotes T
T2989 555-557 IN denotes of
T2988 547-554 NN denotes primacy
T2987 543-546 DT denotes the
T2986 541-542 -COMMA- denotes ,
T2985 538-541 RB denotes ago
T2984 531-537 NN denotes decade
T2983 529-530 DT denotes a
T2982 524-528 IN denotes over
T2981 517-523 JJ denotes little
T2980 515-516 DT denotes A
T2979 512-513 -RRB- denotes ]
T2978 511-512 CD denotes 2
T2977 510-511 -LRB- denotes [
T2976 497-509 NN denotes applications
T2975 485-496 JJ denotes therapeutic
T2974 481-484 JJ denotes new
T3268 2090-2096 JJ denotes higher
T3267 2076-2089 RB denotes significantly
T3266 2071-2075 VB denotes were
T3265 2064-2070 NN denotes fluids
T3264 2055-2063 JJ denotes synovial
T3263 2052-2054 IN denotes in
T3262 2046-2051 NN denotes IL-17
T3261 2043-2045 IN denotes of
T3260 2036-2042 NN denotes Levels
T3259 2033-2034 -RRB- denotes ]
T2973 478-480 IN denotes of
T2972 466-477 NN denotes development
T2971 462-465 DT denotes the
T2970 459-461 IN denotes in
T2969 453-458 NN denotes issue
T2968 443-452 JJ denotes important
T2967 439-442 DT denotes the
T2966 434-438 VB denotes been
T2965 430-433 VB denotes has
T2964 420-429 NN denotes cytokines
T2963 407-419 JJ denotes inflammatory
T2962 403-406 JJ denotes key
T2961 400-402 IN denotes of
T2960 391-399 NN denotes blockade
T2959 387-390 DT denotes the
T2958 382-386 IN denotes that
T2957 374-381 VB denotes suggest
T2956 371-373 CD denotes -1
T2955 370-371 -RRB- denotes )
T2954 368-370 NN denotes IL
T2953 367-368 -LRB- denotes (
T2952 355-366 NN denotes interleukin
T2951 351-354 CC denotes and
T2950 349-350 -RRB- denotes )
T2949 347-349 NN denotes -α
T2948 346-347 -RRB- denotes )
T2947 343-346 NN denotes TNF
T2946 342-343 -LRB- denotes (
T2945 335-341 NN denotes factor
T2944 326-334 NN denotes necrosis
T2943 320-325 NN denotes tumor
T2942 317-319 IN denotes of
T2941 306-316 NN denotes inhibitors
T2940 301-305 IN denotes with
T2939 292-300 VB denotes obtained
T2938 283-291 NN denotes benefits
T2937 274-282 JJ denotes clinical
T2936 264-273 JJ denotes favorable
T2935 260-263 DT denotes The
T2934 257-258 -RRB- denotes ]
T2933 256-257 CD denotes 1
T2932 255-256 -LRB- denotes [
T2931 252-254 NN denotes RA
T2930 249-251 IN denotes in
T2929 242-248 NN denotes joints
T2928 239-241 IN denotes of
T2927 227-238 NN denotes destruction
T2926 223-226 DT denotes the
T2925 220-222 IN denotes in
T2924 210-219 JJ denotes important
T2923 207-209 VB denotes be
T2922 204-206 TO denotes to
T2921 198-203 VB denotes known
T2920 194-197 VB denotes are
T2919 188-193 NN denotes cells
T2918 182-187 DT denotes these
T2917 177-181 IN denotes from
T2916 168-176 VB denotes released
T2915 158-167 NN denotes cytokines
T2914 142-157 JJ denotes Proinflammatory
T2913 129-140 NN denotes hyperplasia
T2912 120-128 JJ denotes synovial
T2911 116-119 CC denotes and
T2910 114-115 -COMMA- denotes ,
T2909 109-114 NN denotes joint
T2908 105-108 DT denotes the
T2907 100-104 IN denotes into
T2906 94-99 NN denotes cells
T2905 92-93 NN denotes T
T2904 88-91 CC denotes and
T2903 76-87 NN denotes macrophages
T2902 73-75 IN denotes of
T2901 59-72 NN denotes infiltrations
T2900 56-58 IN denotes by
T2899 42-55 VB denotes characterized
T2898 39-41 VB denotes is
T2897 37-38 -RRB- denotes )
T2896 35-37 NN denotes RA
T2895 34-35 -LRB- denotes (
T2894 24-33 NN denotes arthritis
T2893 13-23 JJ denotes Rheumatoid
T3042 889-893 NN denotes IL-1
T3041 879-888 VB denotes including
T3040 869-878 NN denotes cytokines
T3039 858-868 NN denotes fibroblast
T3038 854-857 CC denotes and
T3037 843-853 NN denotes macrophage
T3036 835-842 IN denotes whereas
T3035 833-834 -COMMA- denotes ,
T3034 831-833 NN denotes RA
T3033 828-830 IN denotes of
T3032 821-827 NN denotes joints
T3031 817-820 DT denotes the
T3030 814-816 IN denotes in
T3029 801-813 NN denotes interferon-γ
T3028 797-800 CC denotes and
T3027 792-796 NN denotes IL-2
T3026 789-791 IN denotes as
T3025 784-788 JJ denotes such
T3024 774-783 NN denotes cytokines
T3023 761-773 JJ denotes cell-derived
T3398 2822-2833 VB denotes investigate
R1151 T2894 T2893 arg1Of arthritis,Rheumatoid
R1152 T2894 T2895 arg1Of arthritis,(
R1153 T2894 T2898 arg1Of arthritis,is
R1154 T2894 T2899 arg2Of arthritis,characterized
R1155 T2896 T2895 arg2Of RA,(
R1156 T2897 T2895 arg3Of ),(
R1157 T2899 T2898 arg2Of characterized,is
R1158 T2901 T2899 arg1Of infiltrations,characterized
R1159 T2901 T2900 arg2Of infiltrations,by
R1160 T2901 T2902 arg1Of infiltrations,of
R1161 T2903 T2904 arg1Of macrophages,and
R1162 T2904 T2907 arg1Of and,into
R1163 T2904 T2911 arg1Of and,and
R1164 T2906 T2904 arg2Of cells,and
R1165 T2906 T2905 arg1Of cells,T
R1166 T2909 T2907 arg2Of joint,into
R1167 T2909 T2908 arg1Of joint,the
R1168 T2911 T2902 arg2Of and,of
R1169 T2911 T2910 arg1Of and,","
R1170 T2913 T2911 arg2Of hyperplasia,and
R1171 T2913 T2912 arg1Of hyperplasia,synovial
R1172 T2915 T2914 arg1Of cytokines,Proinflammatory
R1173 T2915 T2916 arg2Of cytokines,released
R1174 T2915 T2920 arg1Of cytokines,are
R1175 T2915 T2921 arg2Of cytokines,known
R1176 T2915 T2923 arg1Of cytokines,be
R1177 T2915 T2924 arg1Of cytokines,important
R1178 T2916 T2917 arg1Of released,from
R1179 T2919 T2917 arg2Of cells,from
R1180 T2919 T2918 arg1Of cells,these
R1181 T2921 T2920 arg2Of known,are
R1182 T2921 T2932 arg1Of known,[
R1183 T2923 T2921 arg3Of be,known
R1184 T2923 T2922 arg1Of be,to
R1185 T2924 T2923 arg2Of important,be
R1186 T2924 T2925 arg1Of important,in
R1187 T2927 T2925 arg2Of destruction,in
R1188 T2927 T2926 arg1Of destruction,the
R1189 T2927 T2928 arg1Of destruction,of
R1190 T2927 T2930 arg1Of destruction,in
R1191 T2929 T2928 arg2Of joints,of
R1192 T2931 T2930 arg2Of RA,in
R1193 T2933 T2932 arg2Of 1,[
R1194 T2934 T2932 arg3Of ],[
R1195 T2938 T2935 arg1Of benefits,The
R1196 T2938 T2936 arg1Of benefits,favorable
R1197 T2938 T2937 arg1Of benefits,clinical
R1198 T2938 T2939 arg2Of benefits,obtained
R1199 T2938 T2950 arg1Of benefits,)
R1200 T2938 T2951 arg1Of benefits,and
R1201 T2939 T2940 arg1Of obtained,with
R1202 T2941 T2940 arg2Of inhibitors,with
R1203 T2941 T2942 arg1Of inhibitors,of
R1204 T2945 T2943 arg1Of factor,tumor
R1205 T2945 T2944 arg1Of factor,necrosis
R1206 T2945 T2946 arg1Of factor,(
R1207 T2947 T2946 arg2Of TNF,(
R1208 T2948 T2946 arg3Of ),(
R1209 T2949 T2942 arg2Of -α,of
R1210 T2949 T2945 arg1Of -α,factor
R1211 T2951 T2957 arg1Of and,suggest
R1212 T2952 T2951 arg2Of interleukin,and
R1213 T2952 T2953 arg1Of interleukin,(
R1214 T2952 T2956 arg1Of interleukin,-1
R1215 T2954 T2953 arg2Of IL,(
R1216 T2955 T2953 arg3Of ),(
R1217 T2960 T2959 arg1Of blockade,the
R1218 T2960 T2961 arg1Of blockade,of
R1219 T2960 T2965 arg1Of blockade,has
R1220 T2960 T2966 arg1Of blockade,been
R1221 T2964 T2961 arg2Of cytokines,of
R1222 T2964 T2962 arg1Of cytokines,key
R1223 T2964 T2963 arg1Of cytokines,inflammatory
R1224 T2966 T2957 arg2Of been,suggest
R1225 T2966 T2958 arg1Of been,that
R1226 T2966 T2965 arg2Of been,has
R1227 T2966 T2970 arg1Of been,in
R1228 T2966 T2977 arg1Of been,[
R1229 T2969 T2966 arg2Of issue,been
R1230 T2969 T2967 arg1Of issue,the
R1231 T2969 T2968 arg1Of issue,important
R1232 T2972 T2970 arg2Of development,in
R1233 T2972 T2971 arg1Of development,the
R1234 T2972 T2973 arg1Of development,of
R1235 T2976 T2973 arg2Of applications,of
R1236 T2976 T2974 arg1Of applications,new
R1237 T2976 T2975 arg1Of applications,therapeutic
R1238 T2978 T2977 arg2Of 2,[
R1239 T2979 T2977 arg3Of ],[
R1240 T2981 T2980 arg1Of little,A
R1241 T2983 T2982 arg1Of a,over
R1242 T2984 T2983 arg1Of decade,a
R1243 T2985 T2981 arg1Of ago,little
R1244 T2985 T2984 arg1Of ago,decade
R1245 T2988 T2987 arg1Of primacy,the
R1246 T2988 T2989 arg1Of primacy,of
R1247 T2988 T2992 arg1Of primacy,in
R1248 T2988 T2999 arg1Of primacy,as
R1249 T2988 T3001 arg1Of primacy,was
R1250 T2988 T3002 arg1Of primacy,undisputed
R1251 T2991 T2989 arg2Of cells,of
R1252 T2991 T2990 arg1Of cells,T
R1253 T2994 T2992 arg2Of pathogenesis,in
R1254 T2994 T2993 arg1Of pathogenesis,the
R1255 T2994 T2995 arg1Of pathogenesis,of
R1256 T2997 T2995 arg2Of disease,of
R1257 T2997 T2996 arg1Of disease,autoimmune
R1258 T2999 T2998 arg1Of as,such
R1259 T3000 T2999 arg2Of RA,as
R1260 T3001 T2985 arg1Of was,ago
R1261 T3001 T2986 arg1Of was,","
R1262 T3001 T3003 arg1Of was,because
R1263 T3002 T3001 arg2Of undisputed,was
R1264 T3004 T3005 arg1Of they,are
R1265 T3005 T3003 arg2Of are,because
R1266 T3009 T3005 arg2Of population,are
R1267 T3009 T3006 arg1Of population,the
R1268 T3009 T3007 arg1Of population,largest
R1269 T3009 T3008 arg1Of population,cell
R1270 T3009 T3010 arg1Of population,infiltrating
R1271 T3012 T3010 arg2Of synovium,infiltrating
R1272 T3012 T3011 arg1Of synovium,the
R1273 T3016 T3015 arg1Of series,a
R1274 T3016 T3017 arg1Of series,of
R1275 T3016 T3019 arg1Of series,demonstrated
R1276 T3018 T3017 arg2Of studies,of
R1277 T3019 T3013 arg1Of demonstrated,However
R1278 T3019 T3014 arg1Of demonstrated,","
R1279 T3019 T3035 arg1Of demonstrated,","
R1280 T3019 T3036 arg1Of demonstrated,whereas
R1281 T3020 T3019 arg2Of paucity,demonstrated
R1282 T3020 T3021 arg1Of paucity,of
R1283 T3024 T3021 arg2Of cytokines,of
R1284 T3024 T3022 arg1Of cytokines,T
R1285 T3024 T3023 arg1Of cytokines,cell-derived
R1286 T3024 T3026 arg1Of cytokines,as
R1287 T3026 T3025 arg1Of as,such
R1288 T3027 T3028 arg1Of IL-2,and
R1289 T3028 T3026 arg2Of and,as
R1290 T3028 T3030 arg1Of and,in
R1291 T3029 T3028 arg2Of interferon-γ,and
R1292 T3032 T3030 arg2Of joints,in
R1293 T3032 T3031 arg1Of joints,the
R1294 T3032 T3033 arg1Of joints,of
R1295 T3034 T3033 arg2Of RA,of
R1296 T3037 T3038 arg1Of macrophage,and
R1297 T3039 T3038 arg2Of fibroblast,and
R1298 T3040 T3037 arg1Of cytokines,macrophage
R1299 T3040 T3039 arg1Of cytokines,fibroblast
R1300 T3040 T3041 arg1Of cytokines,including
R1301 T3040 T3051 arg1Of cytokines,were
R1302 T3040 T3052 arg1Of cytokines,abundant
R1303 T3042 T3043 arg1Of IL-1,","
R1304 T3043 T3045 arg1Of ",",","
R1305 T3044 T3043 arg2Of IL-6,","
R1306 T3045 T3047 arg1Of ",",","
R1307 T3046 T3045 arg2Of IL-15,","
R1308 T3047 T3049 arg1Of ",",and
R1309 T3048 T3047 arg2Of IL-18,","
R1310 T3049 T3041 arg2Of and,including
R1311 T3050 T3049 arg2Of TNF-α,and
R1312 T3051 T3036 arg2Of were,whereas
R1313 T3051 T3053 arg1Of were,in
R1314 T3052 T3051 arg2Of abundant,were
R1315 T3055 T3053 arg2Of synovium,in
R1316 T3055 T3054 arg1Of synovium,rheumatoid
R1317 T3057 T3056 arg1Of paradox,This
R1318 T3057 T3058 arg1Of paradox,has
R1319 T3057 T3059 arg1Of paradox,questioned
R1320 T3059 T3058 arg2Of questioned,has
R1321 T3061 T3059 arg2Of role,questioned
R1322 T3061 T3060 arg1Of role,the
R1323 T3061 T3062 arg1Of role,of
R1324 T3061 T3065 arg1Of role,in
R1325 T3064 T3062 arg2Of cells,of
R1326 T3064 T3063 arg1Of cells,T
R1327 T3067 T3065 arg2Of pathogenesis,in
R1328 T3067 T3066 arg1Of pathogenesis,the
R1329 T3067 T3068 arg1Of pathogenesis,of
R1330 T3069 T3068 arg2Of RA,of
R1331 T3069 T3070 arg1Of RA,[
R1332 T3071 T3070 arg2Of 3,[
R1333 T3072 T3070 arg3Of ],[
R1334 T3074 T3075 arg1Of we,have
R1335 T3074 T3077 arg1Of we,demonstrated
R1336 T3077 T3073 arg2Of demonstrated,Because
R1337 T3077 T3075 arg2Of demonstrated,have
R1338 T3077 T3076 arg1Of demonstrated,already
R1339 T3077 T3105 arg1Of demonstrated,in
R1340 T3080 T3078 arg1Of proliferation,the
R1341 T3080 T3079 arg2Of proliferation,enhanced
R1342 T3080 T3081 arg1Of proliferation,of
R1343 T3080 T3086 arg1Of proliferation,","
R1344 T3080 T3088 arg1Of proliferation,to
R1345 T3080 T3093 arg1Of proliferation,and
R1346 T3085 T3081 arg2Of cells,of
R1347 T3085 T3082 arg1Of cells,antigen
R1348 T3085 T3083 arg1Of cells,specific
R1349 T3085 T3084 arg1Of cells,T
R1350 T3088 T3087 arg1Of to,especially
R1351 T3091 T3088 arg2Of collagen,to
R1352 T3091 T3089 arg1Of collagen,type
R1353 T3091 T3090 arg1Of collagen,II
R1354 T3093 T3077 arg2Of and,demonstrated
R1355 T3093 T3092 arg1Of and,","
R1356 T3095 T3093 arg2Of skewing,and
R1357 T3095 T3094 arg1Of skewing,the
R1358 T3095 T3096 arg1Of skewing,of
R1359 T3102 T3101 arg2Of Th1,(
R1360 T3103 T3101 arg3Of ),(
R1361 T3104 T3096 arg2Of cytokines,of
R1362 T3104 T3097 arg1Of cytokines,T
R1363 T3104 T3098 arg1Of cytokines,helper
R1364 T3104 T3099 arg1Of cytokines,type
R1365 T3104 T3100 arg1Of cytokines,1
R1366 T3104 T3101 arg1Of cytokines,(
R1367 T3106 T3105 arg2Of RA,in
R1368 T3106 T3107 arg1Of RA,[
R1369 T3108 T3107 arg2Of 4,[
R1370 T3109 T3107 arg3Of ],[
R1371 T3112 T3111 arg1Of role,the
R1372 T3112 T3113 arg1Of role,of
R1373 T3112 T3116 arg1Of role,needs
R1374 T3112 T3118 arg1Of role,be
R1375 T3112 T3119 arg2Of role,elucidated
R1376 T3115 T3113 arg2Of cells,of
R1377 T3115 T3114 arg1Of cells,T
R1378 T3116 T3073 arg1Of needs,Because
R1379 T3116 T3110 arg1Of needs,","
R1380 T3119 T3116 arg2Of elucidated,needs
R1381 T3119 T3117 arg1Of elucidated,to
R1382 T3119 T3118 arg2Of elucidated,be
R1383 T3119 T3120 arg1Of elucidated,in
R1384 T3122 T3120 arg2Of aspects,in
R1385 T3122 T3121 arg1Of aspects,different
R1386 T3123 T3124 arg1Of IL-17,is
R1387 T3125 T3124 arg2Of one,is
R1388 T3125 T3126 arg1Of one,of
R1389 T3129 T3126 arg2Of cytokines,of
R1390 T3129 T3127 arg1Of cytokines,the
R1391 T3129 T3128 arg1Of cytokines,inflammatory
R1392 T3129 T3130 arg2Of cytokines,secreted
R1393 T3135 T3130 arg1Of cells,secreted
R1394 T3135 T3131 arg1Of cells,mainly
R1395 T3135 T3132 arg2Of cells,by
R1396 T3135 T3133 arg2Of cells,activated
R1397 T3135 T3134 arg1Of cells,T
R1398 T3135 T3136 arg1Of cells,","
R1399 T3135 T3137 arg1Of cells,which
R1400 T3135 T3138 arg1Of cells,can
R1401 T3135 T3139 arg1Of cells,induce
R1402 T3139 T3138 arg2Of induce,can
R1403 T3139 T3145 arg1Of induce,[
R1404 T3140 T3141 arg1Of IL-6,and
R1405 T3141 T3139 arg2Of and,induce
R1406 T3141 T3143 arg1Of and,by
R1407 T3142 T3141 arg2Of IL-8,and
R1408 T3144 T3143 arg2Of fibroblasts,by
R1409 T3146 T3145 arg2Of 5,[
R1410 T3147 T3145 arg3Of ],[
R1411 T3149 T3148 arg1Of cytokine,This
R1412 T3149 T3150 arg1Of cytokine,is
R1413 T3149 T3151 arg1Of cytokine,of
R1414 T3150 T3153 arg1Of is,for
R1415 T3150 T3157 arg1Of is,:
R1416 T3151 T3150 arg2Of of,is
R1417 T3152 T3151 arg2Of interest,of
R1418 T3156 T3153 arg2Of reasons,for
R1419 T3156 T3154 arg1Of reasons,two
R1420 T3156 T3155 arg1Of reasons,major
R1421 T3158 T3159 arg1Of first,","
R1422 T3160 T3159 arg2Of similarly,","
R1423 T3160 T3161 arg1Of similarly,to
R1424 T3162 T3163 arg1Of TNF-α,and
R1425 T3163 T3161 arg2Of and,to
R1426 T3164 T3163 arg2Of IL-1,and
R1427 T3166 T3167 arg1Of IL-17,has
R1428 T3167 T3157 arg2Of has,:
R1429 T3167 T3158 arg1Of has,first
R1430 T3167 T3160 arg1Of has,similarly
R1431 T3167 T3165 arg1Of has,","
R1432 T3167 T3170 arg1Of has,;
R1433 T3169 T3167 arg2Of properties,has
R1434 T3169 T3168 arg1Of properties,proinflammatory
R1435 T3173 T3174 arg1Of it,is
R1436 T3173 T3175 arg2Of it,produced
R1437 T3175 T3170 arg2Of produced,;
R1438 T3175 T3171 arg1Of produced,second
R1439 T3175 T3172 arg1Of produced,","
R1440 T3175 T3174 arg2Of produced,is
R1441 T3175 T3179 arg1Of produced,[
R1442 T3178 T3175 arg1Of cells,produced
R1443 T3178 T3176 arg2Of cells,by
R1444 T3178 T3177 arg1Of cells,T
R1445 T3180 T3179 arg2Of 6,[
R1446 T3181 T3179 arg3Of ],[
R1447 T3183 T3182 arg1Of observations,Recent
R1448 T3183 T3184 arg1Of observations,demonstrated
R1449 T3186 T3187 arg1Of IL-17,can
R1450 T3186 T3189 arg1Of IL-17,activate
R1451 T3189 T3184 arg2Of activate,demonstrated
R1452 T3189 T3185 arg1Of activate,that
R1453 T3189 T3187 arg2Of activate,can
R1454 T3189 T3188 arg1Of activate,also
R1455 T3189 T3193 arg1Of activate,by
R1456 T3192 T3189 arg2Of resorption,activate
R1457 T3192 T3190 arg1Of resorption,osteoclastic
R1458 T3192 T3191 arg1Of resorption,bone
R1459 T3195 T3193 arg2Of induction,by
R1460 T3195 T3194 arg1Of induction,the
R1461 T3195 T3196 arg1Of induction,of
R1462 T3195 T3198 arg1Of induction,(
R1463 T3195 T3210 arg1Of induction,","
R1464 T3195 T3211 arg1Of induction,which
R1465 T3195 T3212 arg1Of induction,is
R1466 T3195 T3213 arg2Of induction,involved
R1467 T3197 T3196 arg2Of RANKL,of
R1468 T3200 T3198 arg2Of activator,(
R1469 T3200 T3199 arg1Of activator,receptor
R1470 T3200 T3201 arg1Of activator,of
R1471 T3206 T3205 arg2Of NF-κB,[
R1472 T3207 T3205 arg3Of ],[
R1473 T3208 T3201 arg2Of ligand,of
R1474 T3208 T3202 arg1Of ligand,nuclear
R1475 T3208 T3203 arg1Of ligand,factor
R1476 T3208 T3204 arg1Of ligand,κB
R1477 T3208 T3205 arg1Of ligand,[
R1478 T3209 T3198 arg3Of ),(
R1479 T3213 T3212 arg2Of involved,is
R1480 T3213 T3214 arg1Of involved,in
R1481 T3216 T3214 arg2Of erosion,in
R1482 T3216 T3215 arg1Of erosion,bony
R1483 T3216 T3217 arg1Of erosion,in
R1484 T3218 T3217 arg2Of RA,in
R1485 T3218 T3219 arg1Of RA,[
R1486 T3220 T3219 arg2Of 7,[
R1487 T3221 T3219 arg3Of ],[
R1488 T3222 T3224 arg1Of It,stimulates
R1489 T3222 T3247 arg1Of It,has
R1490 T3224 T3246 arg1Of stimulates,and
R1491 T3226 T3224 arg2Of production,stimulates
R1492 T3226 T3225 arg1Of production,the
R1493 T3226 T3227 arg1Of production,of
R1494 T3226 T3237 arg1Of production,of
R1495 T3227 T3236 arg1Of of,and
R1496 T3228 T3229 arg1Of IL-6,and
R1497 T3229 T3227 arg2Of and,of
R1498 T3229 T3233 arg1Of and,by
R1499 T3232 T3229 arg2Of factor,and
R1500 T3232 T3230 arg1Of factor,leukemia
R1501 T3232 T3231 arg1Of factor,inhibitory
R1502 T3234 T3233 arg2Of synoviocytes,by
R1503 T3236 T3235 arg1Of and,","
R1504 T3237 T3236 arg2Of of,and
R1505 T3239 T3238 arg1Of E2,prostaglandin
R1506 T3239 T3240 arg1Of E2,and
R1507 T3240 T3237 arg2Of and,of
R1508 T3240 T3243 arg1Of and,by
R1509 T3242 T3240 arg2Of oxide,and
R1510 T3242 T3241 arg1Of oxide,nitric
R1511 T3244 T3243 arg2Of chondrocytes,by
R1512 T3246 T3223 arg1Of and,also
R1513 T3246 T3245 arg1Of and,","
R1514 T3247 T3246 arg2Of has,and
R1515 T3249 T3247 arg2Of ability,has
R1516 T3249 T3248 arg1Of ability,the
R1517 T3249 T3250 modOf ability,to
R1518 T3251 T3252 arg1Of differentiate,and
R1519 T3252 T3250 arg1Of and,to
R1520 T3252 T3257 arg1Of and,[
R1521 T3253 T3252 arg2Of activate,and
R1522 T3256 T3251 arg2Of cells,differentiate
R1523 T3256 T3253 arg2Of cells,activate
R1524 T3256 T3254 arg1Of cells,the
R1525 T3256 T3255 arg1Of cells,dendritic
R1526 T3258 T3257 arg2Of 8-10,[
R1527 T3259 T3257 arg3Of ],[
R1528 T3260 T3261 arg1Of Levels,of
R1529 T3260 T3263 arg1Of Levels,in
R1530 T3260 T3266 arg1Of Levels,were
R1531 T3260 T3268 arg1Of Levels,higher
R1532 T3262 T3261 arg2Of IL-17,of
R1533 T3265 T3263 arg2Of fluids,in
R1534 T3265 T3264 arg1Of fluids,synovial
R1535 T3266 T3282 arg1Of were,and
R1536 T3268 T3266 arg2Of higher,were
R1537 T3268 T3267 arg1Of higher,significantly
R1538 T3268 T3269 arg1Of higher,in
R1539 T3268 T3273 arg1Of higher,than
R1540 T3270 T3269 arg2Of patients,in
R1541 T3270 T3271 arg1Of patients,with
R1542 T3272 T3271 arg2Of RA,with
R1543 T3274 T3273 arg2Of in,than
R1544 T3275 T3274 arg2Of patients,in
R1545 T3275 T3276 arg1Of patients,with
R1546 T3277 T3276 arg2Of osteoarthritis,with
R1547 T3277 T3278 arg1Of osteoarthritis,(
R1548 T3279 T3278 arg2Of OA,(
R1549 T3280 T3278 arg3Of ),(
R1550 T3282 T3281 arg1Of and,","
R1551 T3282 T3293 arg1Of and,[
R1552 T3283 T3284 arg1Of it,was
R1553 T3283 T3285 arg2Of it,produced
R1554 T3285 T3282 arg2Of produced,and
R1555 T3285 T3284 arg2Of produced,was
R1556 T3285 T3290 arg1Of produced,in
R1557 T3289 T3285 arg1Of cells,produced
R1558 T3289 T3286 arg2Of cells,by
R1559 T3289 T3287 arg1Of cells,CD4+
R1560 T3289 T3288 arg1Of cells,T
R1561 T3292 T3290 arg2Of synovium,in
R1562 T3292 T3291 arg1Of synovium,the
R1563 T3294 T3293 arg2Of "11,12",[
R1564 T3295 T3293 arg3Of ],[
R1565 T3296 T3297 arg1Of IL-15,","
R1566 T3296 T3298 arg2Of IL-15,secreted
R1567 T3296 T3303 arg1Of IL-15,has
R1568 T3296 T3304 arg1Of IL-15,been
R1569 T3296 T3305 arg2Of IL-15,reported
R1570 T3296 T3307 arg1Of IL-15,be
R1571 T3298 T3299 arg1Of secreted,from
R1572 T3301 T3299 arg2Of macrophages,from
R1573 T3301 T3300 arg2Of macrophages,activated
R1574 T3305 T3302 arg1Of reported,","
R1575 T3305 T3303 arg2Of reported,has
R1576 T3305 T3304 arg2Of reported,been
R1577 T3307 T3305 arg3Of be,reported
R1578 T3307 T3306 arg1Of be,to
R1579 T3307 T3314 arg1Of be,in
R1580 T3307 T3323 arg1Of be,by
R1581 T3307 T3329 arg1Of be,[
R1582 T3310 T3307 arg2Of trigger,be
R1583 T3310 T3308 arg1Of trigger,an
R1584 T3310 T3309 arg1Of trigger,important
R1585 T3310 T3311 arg1Of trigger,of
R1586 T3313 T3311 arg2Of production,of
R1587 T3313 T3312 arg1Of production,IL-17
R1588 T3319 T3314 arg2Of cells,in
R1589 T3319 T3315 arg1Of cells,RA
R1590 T3319 T3316 arg1Of cells,peripheral
R1591 T3319 T3317 arg1Of cells,blood
R1592 T3319 T3318 arg1Of cells,mononuclear
R1593 T3319 T3320 arg1Of cells,(
R1594 T3321 T3320 arg2Of PBMC,(
R1595 T3322 T3320 arg3Of ),(
R1596 T3324 T3325 arg1Of cyclosporine,and
R1597 T3325 T3323 arg2Of and,by
R1598 T3328 T3325 arg2Of pathways,and
R1599 T3328 T3326 arg1Of pathways,steroid
R1600 T3328 T3327 arg1Of pathways,sensitive
R1601 T3330 T3329 arg2Of 13,[
R1602 T3331 T3329 arg3Of ],[
R1603 T3334 T3335 arg1Of Happel,and
R1604 T3335 T3338 arg1Of and,showed
R1605 T3336 T3335 arg2Of colleagues,and
R1606 T3338 T3332 arg1Of showed,Recently
R1607 T3338 T3333 arg1Of showed,","
R1608 T3338 T3337 arg1Of showed,also
R1609 T3340 T3341 arg1Of IL-23,could
R1610 T3340 T3342 arg1Of IL-23,be
R1611 T3342 T3338 arg2Of be,showed
R1612 T3342 T3339 arg1Of be,that
R1613 T3342 T3341 arg2Of be,could
R1614 T3345 T3342 arg2Of trigger,be
R1615 T3345 T3343 arg1Of trigger,an
R1616 T3345 T3344 arg1Of trigger,efficient
R1617 T3345 T3346 arg1Of trigger,of
R1618 T3345 T3349 arg1Of trigger,from
R1619 T3348 T3346 arg2Of production,of
R1620 T3348 T3347 arg1Of production,IL-17
R1621 T3351 T3352 arg1Of CD4+,and
R1622 T3353 T3352 arg2Of CD8+,and
R1623 T3355 T3349 arg2Of cells,from
R1624 T3355 T3350 arg1Of cells,both
R1625 T3355 T3351 arg1Of cells,CD4+
R1626 T3355 T3353 arg1Of cells,CD8+
R1627 T3355 T3354 arg1Of cells,T
R1628 T3355 T3356 arg1Of cells,[
R1629 T3357 T3356 arg2Of 14,[
R1630 T3358 T3356 arg3Of ],[
R1631 T3361 T3360 arg1Of contribution,the
R1632 T3361 T3362 arg1Of contribution,of
R1633 T3361 T3364 arg1Of contribution,in
R1634 T3361 T3369 arg1Of contribution,has
R1635 T3361 T3370 arg1Of contribution,been
R1636 T3361 T3371 arg2Of contribution,documented
R1637 T3363 T3362 arg2Of IL-17,of
R1638 T3366 T3364 arg2Of inflammation,in
R1639 T3366 T3365 arg1Of inflammation,joint
R1640 T3366 T3367 arg1Of inflammation,in
R1641 T3368 T3367 arg2Of RA,in
R1642 T3371 T3359 arg2Of documented,Although
R1643 T3371 T3369 arg2Of documented,has
R1644 T3371 T3370 arg2Of documented,been
R1645 T3371 T3372 arg1Of documented,in
R1646 T3374 T3372 arg2Of studies,in
R1647 T3374 T3373 arg1Of studies,earlier
R1648 T3374 T3375 arg1Of studies,[
R1649 T3376 T3375 arg2Of "12,15,16",[
R1650 T3377 T3375 arg3Of ],[
R1651 T3383 T3379 arg1Of pathway,the
R1652 T3383 T3380 arg1Of pathway,intracellular
R1653 T3383 T3381 arg1Of pathway,signal
R1654 T3383 T3382 arg1Of pathway,transduction
R1655 T3383 T3384 arg1Of pathway,for
R1656 T3383 T3387 arg1Of pathway,remains
R1657 T3383 T3388 arg1Of pathway,uncertain
R1658 T3386 T3384 arg2Of production,for
R1659 T3386 T3385 arg1Of production,IL-17
R1660 T3387 T3359 arg1Of remains,Although
R1661 T3387 T3378 arg1Of remains,","
R1662 T3388 T3387 arg2Of uncertain,remains
R1663 T3392 T3389 arg2Of study,In
R1664 T3392 T3390 arg1Of study,the
R1665 T3392 T3391 arg1Of study,present
R1666 T3393 T3394 arg1Of we,used
R1667 T3393 T3398 arg1Of we,investigate
R1668 T3394 T3389 arg1Of used,In
R1669 T3396 T3394 arg2Of stimuli,used
R1670 T3396 T3395 arg1Of stimuli,various
R1671 T3398 T3394 arg3Of investigate,used
R1672 T3398 T3397 arg1Of investigate,to
R1673 T3400 T3398 arg2Of production,investigate
R1674 T3400 T3399 arg1Of production,IL-17
R1675 T3400 T3401 arg1Of production,in
R1676 T3402 T3403 arg1Of PBMC,of
R1677 T3402 T3407 arg1Of PBMC,and
R1678 T3404 T3403 arg2Of patients,of
R1679 T3404 T3405 arg1Of patients,with
R1680 T3406 T3405 arg2Of RA,with
R1681 T3407 T3401 arg2Of and,in
R1682 T3411 T3407 arg2Of pathway,and
R1683 T3411 T3408 arg1Of pathway,its
R1684 T3411 T3409 arg1Of pathway,signaling
R1685 T3411 T3410 arg1Of pathway,transduction
R1686 T3412 T3413 arg1Of We,found
R1687 T3418 T3415 arg1Of pathway,the
R1688 T3418 T3416 arg1Of pathway,intracellular
R1689 T3418 T3417 arg1Of pathway,signaling
R1690 T3418 T3419 arg1Of pathway,involving
R1691 T3418 T3428 arg1Of pathway,might
R1692 T3418 T3429 arg1Of pathway,be
R1693 T3418 T3430 arg2Of pathway,involved
R1694 T3423 T3422 arg2Of PI3K,(
R1695 T3424 T3422 arg3Of ),(
R1696 T3425 T3426 arg1Of /Akt,and
R1697 T3426 T3419 arg2Of and,involving
R1698 T3426 T3420 arg1Of and,phosphoinositide
R1699 T3426 T3421 arg1Of and,3-kinase
R1700 T3426 T3422 arg1Of and,(
R1701 T3427 T3426 arg2Of NF-κB,and
R1702 T3430 T3413 arg2Of involved,found
R1703 T3430 T3414 arg1Of involved,that
R1704 T3430 T3428 arg2Of involved,might
R1705 T3430 T3429 arg2Of involved,be
R1706 T3430 T3431 arg1Of involved,in
R1707 T3433 T3431 arg2Of overproduction,in
R1708 T3433 T3432 arg1Of overproduction,the
R1709 T3433 T3434 arg1Of overproduction,of
R1710 T3439 T3434 arg2Of IL-17,of
R1711 T3439 T3435 arg1Of IL-17,the
R1712 T3439 T3436 arg1Of IL-17,key
R1713 T3439 T3437 arg1Of IL-17,inflammatory
R1714 T3439 T3438 arg1Of IL-17,cytokine
R1715 T3439 T3440 arg1Of IL-17,in
R1716 T3441 T3440 arg2Of RA,in
R1717 T3443 T3442 arg1Of results,These
R1718 T3443 T3444 arg1Of results,might
R1719 T3443 T3445 arg1Of results,provide
R1720 T3445 T3444 arg2Of provide,might
R1721 T3445 T3448 arg1Of provide,into
R1722 T3447 T3445 arg2Of insights,provide
R1723 T3447 T3446 arg1Of insights,new
R1724 T3450 T3448 arg2Of pathogenesis,into
R1725 T3450 T3449 arg1Of pathogenesis,the
R1727 T3450 T3451 arg1Of pathogenesis,of
R1729 T3450 T3456 arg1Of pathogenesis,for
R1730 T3452 T3453 arg1Of RA,and
R1733 T3453 T3451 arg2Of and,of
R1734 T3455 T3453 arg2Of directions,and
R1735 T3455 T3454 arg1Of directions,future
R1740 T3458 T3457 arg1Of therapeutic,new
R1742 T3459 T3456 arg2Of strategies,for
R1745 T3459 T3458 arg1Of strategies,therapeutic
R1747 T3459 T3460 arg1Of strategies,in
R1748 T3461 T3460 arg2Of RA,in

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T3466 792-796 Antecedent denotes IL-2
T3465 759-783 Anaphor denotes T cell-derived cytokines
T3464 355-373 Antecedent denotes interleukin (IL)-1
T3463 320-349 Antecedent denotes tumor necrosis factor (TNF)-α
T3462 403-429 Anaphor denotes key inflammatory cytokines
T3481 2046-2051 Antecedent denotes IL-17
T3480 2164-2166 Anaphor denotes it
T3479 1628-1633 Antecedent denotes IL-17
T3478 1810-1812 Anaphor denotes It
T3477 1513-1518 Antecedent denotes IL-17
T3476 1559-1561 Anaphor denotes it
T3475 1374-1379 Anaphor denotes which
T3474 1293-1298 Antecedent denotes IL-17
T3473 1313-1335 Anaphor denotes inflammatory cytokines
T3472 918-923 Antecedent denotes TNF-α
T3471 908-913 Antecedent denotes IL-18
T3470 895-899 Antecedent denotes IL-6
T3469 889-893 Antecedent denotes IL-1
T3468 843-878 Anaphor denotes macrophage and fibroblast cytokines
T3467 801-813 Antecedent denotes interferon-γ
R1749 T3480 T3481 boundBy it,IL-17
R1726 T3462 T3463 boundBy key inflammatory cytokines,tumor necrosis factor (TNF)-α
R1728 T3462 T3464 boundBy key inflammatory cytokines,interleukin (IL)-1
R1731 T3465 T3466 boundBy T cell-derived cytokines,IL-2
R1732 T3465 T3467 boundBy T cell-derived cytokines,interferon-γ
R1736 T3468 T3469 boundBy macrophage and fibroblast cytokines,IL-1
R1737 T3468 T3470 boundBy macrophage and fibroblast cytokines,IL-6
R1738 T3468 T3471 boundBy macrophage and fibroblast cytokines,IL-18
R1739 T3468 T3472 boundBy macrophage and fibroblast cytokines,TNF-α
R1741 T3473 T3474 boundBy inflammatory cytokines,IL-17
R1743 T3475 T3474 boundBy which,IL-17
R1744 T3476 T3477 boundBy it,IL-17
R1746 T3478 T3479 boundBy It,IL-17

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T3484 792-796 Protein denotes IL-2
T3483 355-373 Protein denotes interleukin (IL)-1
T3482 320-349 Protein denotes tumor necrosis factor (TNF)-α
T3514 3099-3104 Protein denotes IL-17
T3513 3012-3015 Protein denotes Akt
T3512 2834-2839 Protein denotes IL-17
T3511 2738-2743 Protein denotes IL-17
T3510 2603-2608 Protein denotes IL-17
T3509 2555-2558 Protein denotes CD8
T3508 2546-2549 Protein denotes CD4
T3507 2519-2524 Protein denotes IL-17
T3506 2480-2485 Protein denotes IL-23
T3505 2313-2318 Protein denotes IL-17
T3504 2221-2226 Protein denotes IL-15
T3503 2183-2186 Protein denotes CD4
T3502 2046-2051 Protein denotes IL-17
T3501 1856-1882 Protein denotes leukemia inhibitory factor
T3500 1847-1851 Protein denotes IL-6
T3499 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3498 1701-1706 Protein denotes RANKL
T3497 1628-1633 Protein denotes IL-17
T3496 1513-1518 Protein denotes IL-17
T3495 1507-1511 Protein denotes IL-1
T3494 1497-1502 Protein denotes TNF-α
T3493 1400-1404 Protein denotes IL-8
T3492 1391-1395 Protein denotes IL-6
T3491 1293-1298 Protein denotes IL-17
T3490 918-923 Protein denotes TNF-α
T3489 908-913 Protein denotes IL-18
T3488 901-906 Protein denotes IL-15
T3487 895-899 Protein denotes IL-6
T3486 889-893 Protein denotes IL-1
T3485 801-813 Protein denotes interferon-γ

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T3712 2555-2558 http://www.uniprot.org/uniprot/P10966 denotes CD8
T3711 2555-2558 http://www.uniprot.org/uniprot/P01732 denotes CD8
T3710 2546-2549 http://www.uniprot.org/uniprot/P01730 denotes CD4
T3709 2183-2186 http://www.uniprot.org/uniprot/P01730 denotes CD4
T3708 1400-1404 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T3707 3099-3104 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3706 2834-2839 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3705 2738-2743 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3704 2603-2608 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3703 2519-2524 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3702 2313-2318 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3701 2046-2051 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3700 1628-1633 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3699 1513-1518 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3698 1293-1298 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3697 2221-2226 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T3696 901-906 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T3695 1847-1851 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3694 1391-1395 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3693 895-899 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3692 801-813 http://www.uniprot.org/uniprot/P01579 denotes interferon-γ
T3691 792-796 http://www.uniprot.org/uniprot/P60568 denotes IL-2
T3690 1497-1502 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T3689 918-923 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T3688 343-349 http://www.uniprot.org/uniprot/P01375 denotes TNF)-α
T3687 918-921 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3686 343-346 http://www.uniprot.org/uniprot/P01375 denotes TNF

UBERON-AE

Id Subject Object Predicate Lexical cue
T2234 2347-2352 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2233 2055-2070 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluids

GO-BP

Id Subject Object Predicate Lexical cue
T2826 3006-3010 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2825 2937-2968 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signaling pathway
T2824 2897-2909 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T2823 2713-2725 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T2822 2887-2917 http://purl.obolibrary.org/obo/GO_0036499 denotes signaling transduction pathway
T2821 2706-2733 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T2820 2887-2917 http://purl.obolibrary.org/obo/GO_0036500 denotes signaling transduction pathway
T2819 2706-2733 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T2818 2887-2917 http://purl.obolibrary.org/obo/GO_0036498 denotes signaling transduction pathway
T2817 2706-2733 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T2816 2951-2968 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T2815 2887-2909 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T2814 2706-2725 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T2813 2951-2960 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2812 2887-2896 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2811 2706-2712 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T2810 2937-2968 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signaling pathway
T2809 2692-2733 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signal transduction pathway
T2808 2937-2968 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signaling pathway
T2807 2692-2733 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signal transduction pathway
T2806 2937-2968 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathway
T2805 2887-2917 http://purl.obolibrary.org/obo/GO_0035556 denotes signaling transduction pathway
T2804 2692-2733 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signal transduction pathway
T2803 2937-2968 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signaling pathway
T2802 2692-2733 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signal transduction pathway
T2801 2618-2630 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2800 2834-2850 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2799 2738-2754 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2798 2519-2535 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2797 2313-2329 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2777 1921-1923 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T2776 1833-1851 http://purl.obolibrary.org/obo/GO_0032675 denotes production of IL-6
T2775 1833-1851 http://purl.obolibrary.org/obo/GO_0032635 denotes production of IL-6
T2774 1665-1680 http://purl.obolibrary.org/obo/GO_0045453 denotes bone resorption
T2773 3162-3174 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2772 1017-1029 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2771 573-585 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2770 466-477 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2769 326-334 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T2768 326-334 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T2767 326-334 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T2766 326-334 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T2796 2834-2850 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2795 2738-2754 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2794 2519-2535 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2793 2313-2329 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2792 2242-2263 http://purl.obolibrary.org/obo/GO_0042116 denotes activated macrophages
T2791 1999-2027 http://purl.obolibrary.org/obo/GO_0001773 denotes activate the dendritic cells
T2790 1999-2027 http://purl.obolibrary.org/obo/GO_0002270 denotes activate the dendritic cells
T2789 1999-2027 http://purl.obolibrary.org/obo/GO_0002266 denotes activate the dendritic cells
T2788 1921-1923 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T2787 1921-1923 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T2786 1921-1923 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T2785 1921-1923 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T2784 1921-1923 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T2783 1921-1923 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T2782 1921-1923 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T2781 1921-1923 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T2780 1921-1923 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T2779 1921-1923 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T2778 1921-1923 http://purl.obolibrary.org/obo/GO_0019787 denotes E2

GO-MF

Id Subject Object Predicate Lexical cue
T3551 3006-3010 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T3550 2480-2485 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T3549 1921-1923 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T3548 1921-1923 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T3547 1921-1923 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T3546 1921-1923 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T3545 1921-1923 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T3544 1921-1923 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T3543 1921-1923 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T3542 1921-1923 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T3541 1921-1923 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T3540 1921-1923 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T3539 1921-1923 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T3538 1921-1923 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T3537 1756-1762 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T3536 1400-1404 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T3535 3099-3104 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3534 2834-2839 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3533 2738-2743 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3532 2603-2608 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3531 2519-2524 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3530 2313-2318 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3529 2046-2051 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3528 1628-1633 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3527 1513-1518 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3526 1293-1298 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3525 908-913 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T3524 2221-2226 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T3523 901-906 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T3522 1847-1851 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3521 1391-1395 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3520 895-899 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3519 801-813 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T3518 792-796 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T3517 1507-1511 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T3516 889-893 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T3515 368-373 http://purl.obolibrary.org/obo/GO_0005149 denotes IL)-1

GO-CC

Id Subject Object Predicate Lexical cue
T3565 2937-2950 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T3564 2692-2705 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T3563 2562-2567 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3562 2365-2370 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3561 2190-2195 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3560 2022-2027 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3559 1579-1584 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3558 1367-1372 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3557 1242-1247 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3556 1127-1132 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3555 1004-1009 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3554 560-565 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3553 188-193 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3552 94-99 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T2751 515-705 Sentence denotes A little over a decade ago, the primacy of T cells in the pathogenesis of autoimmune disease such as RA was undisputed because they are the largest cell population infiltrating the synovium.
T2750 260-514 Sentence denotes The favorable clinical benefits obtained with inhibitors of tumor necrosis factor (TNF)-α) and interleukin (IL)-1 suggest that the blockade of key inflammatory cytokines has been the important issue in the development of new therapeutic applications [2].
T2749 142-259 Sentence denotes Proinflammatory cytokines released from these cells are known to be important in the destruction of joints in RA [1].
T2748 13-141 Sentence denotes Rheumatoid arthritis (RA) is characterized by infiltrations of macrophages and T cells into the joint, and synovial hyperplasia.
T2765 3112-3240 Sentence denotes These results might provide new insights into the pathogenesis of RA and future directions for new therapeutic strategies in RA.
T2764 2919-3111 Sentence denotes We found that the intracellular signaling pathway involving phosphoinositide 3-kinase (PI3K)/Akt and NF-κB might be involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T2763 2774-2918 Sentence denotes In the present study we used various stimuli to investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway.
T2762 2574-2773 Sentence denotes Although the contribution of IL-17 in joint inflammation in RA has been documented in earlier studies [12,15,16], the intracellular signal transduction pathway for IL-17 production remains uncertain.
T2761 2431-2573 Sentence denotes Recently, Happel and colleagues also showed that IL-23 could be an efficient trigger of IL-17 production from both CD4+ and CD8+ T cells [14].
T2760 2221-2430 Sentence denotes IL-15, secreted from activated macrophages, has been reported to be an important trigger of IL-17 production in RA peripheral blood mononuclear cells (PBMC) by cyclosporine and steroid sensitive pathways [13].
T2759 2036-2220 Sentence denotes Levels of IL-17 in synovial fluids were significantly higher in patients with RA than in patients with osteoarthritis (OA), and it was produced by CD4+ T cells in the synovium [11,12].
T2758 1810-2035 Sentence denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes, and has the ability to differentiate and activate the dendritic cells [8-10].
T2757 1590-1809 Sentence denotes Recent observations demonstrated that IL-17 can also activate osteoclastic bone resorption by the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand), which is involved in bony erosion in RA [7].
T2756 1425-1589 Sentence denotes This cytokine is of interest for two major reasons: first, similarly to TNF-α and IL-1, IL-17 has proinflammatory properties; second, it is produced by T cells [6].
T2755 1293-1424 Sentence denotes IL-17 is one of the inflammatory cytokines secreted mainly by activated T cells, which can induce IL-6 and IL-8 by fibroblasts [5].
T2754 1041-1292 Sentence denotes Because we have already demonstrated the enhanced proliferation of antigen specific T cells, especially to type II collagen, and the skewing of T helper type 1 (Th1) cytokines in RA [4], the role of T cells needs to be elucidated in different aspects.
T2753 962-1040 Sentence denotes This paradox has questioned the role of T cells in the pathogenesis of RA [3].
T2752 706-961 Sentence denotes However, a series of studies demonstrated paucity of T cell-derived cytokines such as IL-2 and interferon-γ in the joints of RA, whereas macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α were abundant in rheumatoid synovium.
T17 0-12 Sentence denotes Introduction
T18 13-141 Sentence denotes Rheumatoid arthritis (RA) is characterized by infiltrations of macrophages and T cells into the joint, and synovial hyperplasia.
T19 142-259 Sentence denotes Proinflammatory cytokines released from these cells are known to be important in the destruction of joints in RA [1].
T20 260-514 Sentence denotes The favorable clinical benefits obtained with inhibitors of tumor necrosis factor (TNF)-α) and interleukin (IL)-1 suggest that the blockade of key inflammatory cytokines has been the important issue in the development of new therapeutic applications [2].
T21 515-705 Sentence denotes A little over a decade ago, the primacy of T cells in the pathogenesis of autoimmune disease such as RA was undisputed because they are the largest cell population infiltrating the synovium.
T22 706-961 Sentence denotes However, a series of studies demonstrated paucity of T cell-derived cytokines such as IL-2 and interferon-γ in the joints of RA, whereas macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α were abundant in rheumatoid synovium.
T23 962-1040 Sentence denotes This paradox has questioned the role of T cells in the pathogenesis of RA [3].
T24 1041-1292 Sentence denotes Because we have already demonstrated the enhanced proliferation of antigen specific T cells, especially to type II collagen, and the skewing of T helper type 1 (Th1) cytokines in RA [4], the role of T cells needs to be elucidated in different aspects.
T25 1293-1424 Sentence denotes IL-17 is one of the inflammatory cytokines secreted mainly by activated T cells, which can induce IL-6 and IL-8 by fibroblasts [5].
T26 1425-1589 Sentence denotes This cytokine is of interest for two major reasons: first, similarly to TNF-α and IL-1, IL-17 has proinflammatory properties; second, it is produced by T cells [6].
T27 1590-1809 Sentence denotes Recent observations demonstrated that IL-17 can also activate osteoclastic bone resorption by the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand), which is involved in bony erosion in RA [7].
T28 1810-2035 Sentence denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes, and has the ability to differentiate and activate the dendritic cells [8-10].
T29 2036-2220 Sentence denotes Levels of IL-17 in synovial fluids were significantly higher in patients with RA than in patients with osteoarthritis (OA), and it was produced by CD4+ T cells in the synovium [11,12].
T30 2221-2430 Sentence denotes IL-15, secreted from activated macrophages, has been reported to be an important trigger of IL-17 production in RA peripheral blood mononuclear cells (PBMC) by cyclosporine and steroid sensitive pathways [13].
T31 2431-2573 Sentence denotes Recently, Happel and colleagues also showed that IL-23 could be an efficient trigger of IL-17 production from both CD4+ and CD8+ T cells [14].
T32 2574-2773 Sentence denotes Although the contribution of IL-17 in joint inflammation in RA has been documented in earlier studies [12,15,16], the intracellular signal transduction pathway for IL-17 production remains uncertain.
T33 2774-2918 Sentence denotes In the present study we used various stimuli to investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway.
T34 2919-3111 Sentence denotes We found that the intracellular signaling pathway involving phosphoinositide 3-kinase (PI3K)/Akt and NF-κB might be involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T35 3112-3240 Sentence denotes These results might provide new insights into the pathogenesis of RA and future directions for new therapeutic strategies in RA.

ICD10

Id Subject Object Predicate Lexical cue
T3567 24-33 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T3566 13-33 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes Rheumatoid arthritis

simple1

Id Subject Object Predicate Lexical cue
T3685 3099-3104 Protein denotes IL-17
T3684 3012-3015 Protein denotes Akt
T3683 2834-2839 Protein denotes IL-17
T3682 2738-2743 Protein denotes IL-17
T3681 2603-2608 Protein denotes IL-17
T3680 2555-2558 Protein denotes CD8
T3679 2546-2549 Protein denotes CD4
T3678 2519-2524 Protein denotes IL-17
T3677 2480-2485 Protein denotes IL-23
T3676 2313-2318 Protein denotes IL-17
T3675 2221-2226 Protein denotes IL-15
T3674 2183-2186 Protein denotes CD4
T3673 2046-2051 Protein denotes IL-17
T3672 1856-1882 Protein denotes leukemia inhibitory factor
T3671 1847-1851 Protein denotes IL-6
T3670 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3669 1701-1706 Protein denotes RANKL
T3668 1628-1633 Protein denotes IL-17
T3667 1513-1518 Protein denotes IL-17
T3666 1507-1511 Protein denotes IL-1
T3665 1497-1502 Protein denotes TNF-α
T3664 1400-1404 Protein denotes IL-8
T3663 1391-1395 Protein denotes IL-6
T3662 1293-1298 Protein denotes IL-17
T3661 918-923 Protein denotes TNF-α
T3660 908-913 Protein denotes IL-18
T3659 901-906 Protein denotes IL-15
T3658 895-899 Protein denotes IL-6
T3657 889-893 Protein denotes IL-1
T3656 801-813 Protein denotes interferon-γ
T3655 792-796 Protein denotes IL-2
T3654 355-373 Protein denotes interleukin (IL)-1
T3653 320-349 Protein denotes tumor necrosis factor (TNF)-α

DLUT931

Id Subject Object Predicate Lexical cue
T3812 3035-3043 Regulation denotes involved
T3811 3051-3065 Gene_expression denotes overproduction
T3810 2840-2850 Gene_expression denotes production
T3809 2744-2754 Gene_expression denotes production
T3808 2508-2515 Positive_regulation denotes trigger
T3807 2525-2535 Gene_expression denotes production
T3806 2302-2309 Positive_regulation denotes trigger
T3805 2319-2329 Gene_expression denotes production
T3804 2242-2251 Positive_regulation denotes activated
T3803 2228-2236 Localization denotes secreted
T3802 1818-1828 Positive_regulation denotes stimulates
T3801 1833-1843 Gene_expression denotes production
T3800 1643-1651 Positive_regulation denotes activate
T3799 1774-1782 Regulation denotes involved
T3798 1688-1697 Positive_regulation denotes induction
T3797 1384-1390 Positive_regulation denotes induce
T3796 1336-1344 Localization denotes secreted
T3795 306-316 Negative_regulation denotes inhibitors
T3794 3099-3104 Protein denotes IL-17
T3793 3012-3015 Protein denotes Akt
T3792 2834-2839 Protein denotes IL-17
T3791 2738-2743 Protein denotes IL-17
T3790 2603-2608 Protein denotes IL-17
T3789 2555-2558 Protein denotes CD8
T3788 2546-2549 Protein denotes CD4
T3787 2519-2524 Protein denotes IL-17
T3786 2480-2485 Protein denotes IL-23
T3785 2313-2318 Protein denotes IL-17
T3784 2221-2226 Protein denotes IL-15
T3783 2183-2186 Protein denotes CD4
T3782 2046-2051 Protein denotes IL-17
T3781 1856-1882 Protein denotes leukemia inhibitory factor
T3780 1847-1851 Protein denotes IL-6
T3779 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3778 1701-1706 Protein denotes RANKL
T3777 1628-1633 Protein denotes IL-17
T3776 1513-1518 Protein denotes IL-17
T3775 1507-1511 Protein denotes IL-1
T3774 1497-1502 Protein denotes TNF-α
T3773 1400-1404 Protein denotes IL-8
T3772 1391-1395 Protein denotes IL-6
T3771 1293-1298 Protein denotes IL-17
T3770 918-923 Protein denotes TNF-α
T3769 908-913 Protein denotes IL-18
T3768 901-906 Protein denotes IL-15
T3767 895-899 Protein denotes IL-6
T3766 889-893 Protein denotes IL-1
T3765 801-813 Protein denotes interferon-γ
T3764 792-796 Protein denotes IL-2
T3763 355-373 Protein denotes interleukin (IL)-1
T3762 320-349 Protein denotes tumor necrosis factor (TNF)-α
R1802 T3791 T3809 themeOf IL-17,production
R1803 T3792 T3810 themeOf IL-17,production
R1804 T3794 T3811 themeOf IL-17,overproduction
R1806 T3798 T3799 themeOf induction,involved
R1807 T3798 T3800 themeOf induction,activate
R1809 T3801 T3802 themeOf production,stimulates
R1810 T3801 T3802 themeOf production,stimulates
R1811 T3803 T3804 themeOf secreted,activated
R1813 T3805 T3806 themeOf production,trigger
R1814 T3807 T3808 themeOf production,trigger
R1816 T3811 T3812 themeOf overproduction,involved
R1780 T3762 T3795 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1782 T3763 T3795 themeOf interleukin (IL)-1,inhibitors
R1785 T3771 T3796 themeOf IL-17,secreted
R1786 T3772 T3797 themeOf IL-6,induce
R1787 T3773 T3797 themeOf IL-8,induce
R1790 T3777 T3800 causeOf IL-17,activate
R1791 T3778 T3798 themeOf RANKL,induction
R1793 T3780 T3801 themeOf IL-6,production
R1794 T3781 T3801 themeOf leukemia inhibitory factor,production
R1796 T3784 T3803 themeOf IL-15,secreted
R1797 T3785 T3805 themeOf IL-17,production
R1798 T3786 T3808 causeOf IL-23,trigger
R1800 T3787 T3807 themeOf IL-17,production

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T4513 2313-2318 Protein denotes IL-17
T4512 558-565 Entity denotes T cells
T4511 2221-2263 Protein denotes IL-15, secreted from activated macrophages
T4510 1400-1423 Protein denotes IL-8 by fibroblasts [5]
T4509 651-678 Entity denotes the largest cell population
T4508 2854-2858 Entity denotes PBMC
T4507 2634-2636 Protein denotes RA
T4506 3069-3110 Protein denotes the key inflammatory cytokine IL-17 in RA
T4505 1153-1164 Entity denotes II collagen
T4504 1237-1247 Entity denotes of T cells
T4503 1306-1335 Protein denotes of the inflammatory cytokines
T4502 843-853 Entity denotes macrophage
T4501 918-923 Protein denotes TNF-α
T4500 1033-1039 Protein denotes RA [3]
T4499 801-834 Protein denotes interferon-γ in the joints of RA,
T4498 999-1009 Entity denotes of T cells
T4497 2008-2034 Entity denotes the dendritic cells [8-10]
T4496 2333-2335 Protein denotes RA
T4601 1810-1956 Positive_regulation denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4600 1810-1956 Positive_regulation denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4599 1829-1956 Gene_expression denotes the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4598 1829-1956 Gene_expression denotes the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4597 634-704 Binding denotes because they are the largest cell population infiltrating the synovium
T4596 1684-1764 Gene_expression denotes the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),
T4595 1684-1764 Positive_regulation denotes the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),
T4594 801-834 Localization denotes interferon-γ in the joints of RA,
T4593 843-924 Localization denotes macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α
T4592 158-193 Regulation denotes cytokines released from these cells
T4591 759-791 Gene_expression denotes T cell-derived cytokines such as
T4590 2221-2263 Gene_expression denotes IL-15, secreted from activated macrophages
T4589 2516-2545 Gene_expression denotes of IL-17 production from both
T4588 2310-2329 Gene_expression denotes of IL-17 production
T4587 2822-2917 Gene_expression denotes investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway
T4586 2738-2754 Gene_expression denotes IL-17 production
T4585 1220-1227 Protein denotes RA [4],
T4584 3237-3239 Protein denotes RA
T4583 1408-1423 Entity denotes fibroblasts [5]
T4582 92-99 Entity denotes T cells
T4581 306-349 Entity denotes inhibitors of tumor necrosis factor (TNF)-α
T4580 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T4579 1302-1335 Protein denotes one of the inflammatory cytokines
T4578 2242-2263 Entity denotes activated macrophages
T4577 1928-1956 Entity denotes nitric oxide by chondrocytes
T4576 1425-1438 Protein denotes This cytokine
T4575 1944-1956 Entity denotes chondrocytes
T4574 3020-3025 Protein denotes NF-κB
T4573 908-913 Protein denotes IL-18
T4572 895-899 Protein denotes IL-6
T4571 889-893 Protein denotes IL-1
T4570 2398-2415 Entity denotes steroid sensitive
T4569 1105-1132 Entity denotes of antigen specific T cells
T4568 1907-1923 Entity denotes prostaglandin E2
T4567 320-349 Protein denotes tumor necrosis factor (TNF)-α
T4566 2180-2195 Entity denotes by CD4+ T cells
T4565 1856-1882 Protein denotes leukemia inhibitory factor
T4564 1182-1227 Protein denotes of T helper type 1 (Th1) cytokines in RA [4],
T4563 1391-1395 Protein denotes IL-6
T4562 589-618 Protein denotes autoimmune disease such as RA
T4561 1847-1851 Protein denotes IL-6
T4560 2546-2549 Protein denotes CD4
T4559 3178-3180 Protein denotes RA
T4558 407-429 Protein denotes inflammatory cytokines
T4557 2555-2572 Entity denotes CD8+ T cells [14]
T4556 1507-1512 Protein denotes IL-1,
T4555 2834-2839 Protein denotes IL-17
T4554 2114-2116 Protein denotes RA
T4553 1108-1115 Entity denotes antigen
T4552 1628-1633 Protein denotes IL-17
T4551 76-87 Entity denotes macrophages
T4550 1182-1227 Entity denotes of T helper type 1 (Th1) cytokines in RA [4],
T4549 901-906 Protein denotes IL-15
T4548 2519-2524 Protein denotes IL-17
T4547 2876-2878 Protein denotes RA
T4546 759-796 Protein denotes T cell-derived cytokines such as IL-2
T4545 1194-1206 Protein denotes type 1 (Th1)
T4544 1153-1164 Entity denotes II collagen
T4543 2937-2950 Entity denotes intracellular
T4542 2600-2608 Protein denotes of IL-17
T4541 2979-3011 Protein denotes phosphoinositide 3-kinase (PI3K)
T4540 1293-1298 Protein denotes IL-17
T4539 2155-2157 Entity denotes OA
T4538 759-791 Protein denotes T cell-derived cytokines such as
T4537 182-193 Entity denotes these cells
T4536 828-833 Protein denotes of RA
T4535 3006-3010 Protein denotes PI3K
T4534 858-868 Entity denotes fibroblast
T4533 843-923 Protein denotes macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α
T4532 1574-1588 Entity denotes by T cells [6]
T4531 759-773 Entity denotes T cell-derived
T4530 1802-1808 Protein denotes RA [7]
T4529 2738-2743 Protein denotes IL-17
T4528 1497-1502 Protein denotes TNF-α
T4527 158-193 Protein denotes cytokines released from these cells
T4526 2333-2377 Entity denotes RA peripheral blood mononuclear cells (PBMC)
T4525 355-373 Protein denotes interleukin (IL)-1
T4524 1698-1706 Protein denotes of RANKL
T4523 2046-2051 Protein denotes IL-17
T4522 2372-2376 Entity denotes PBMC
T4521 252-254 Protein denotes RA
T4520 1886-1899 Entity denotes synoviocytes,
T4519 1907-1920 Entity denotes prostaglandin
T4518 35-37 Protein denotes RA
T4517 3069-3110 Protein denotes the key inflammatory cytokine IL-17 in RA
T4516 3108-3110 Protein denotes RA
T4515 2480-2485 Protein denotes IL-23
T4514 1513-1518 Protein denotes IL-17
R2445 T4499 T4594 themeOf "interferon-γ in the joints of RA,","interferon-γ in the joints of RA,"
R2447 T4502 T4593 locationOf macrophage,"macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2449 T4511 T4590 themeOf "IL-15, secreted from activated macrophages","IL-15, secreted from activated macrophages"
R2450 T4513 T4588 themeOf IL-17,of IL-17 production
R2451 T4524 T4595 themeOf of RANKL,"the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),"
R2452 T4598 T4601 themeOf "the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes","It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2453 T4599 T4600 themeOf "the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes","It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2454 T4524 T4596 themeOf of RANKL,"the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),"
R2455 T4527 T4592 themeOf cytokines released from these cells,cytokines released from these cells
R2456 T4529 T4586 themeOf IL-17,IL-17 production
R2457 T4533 T4593 themeOf "macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α","macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2460 T4534 T4593 locationOf fibroblast,"macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2461 T4538 T4591 themeOf T cell-derived cytokines such as,T cell-derived cytokines such as
R2462 T4548 T4589 themeOf IL-17,of IL-17 production from both
R2467 T4555 T4587 themeOf IL-17,investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway
R2474 T4561 T4599 themeOf IL-6,"the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2478 T4565 T4598 themeOf leukemia inhibitory factor,"the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T4443 3239-3240 . denotes .
T4442 3237-3239 NNP denotes RA
T4441 3234-3236 IN denotes in
T4440 3223-3233 NNS denotes strategies
T4439 3211-3222 JJ denotes therapeutic
T4438 3207-3210 JJ denotes new
T4437 3203-3206 IN denotes for
T4436 3192-3202 NNS denotes directions
T4435 3185-3191 JJ denotes future
T4434 3181-3184 CC denotes and
T4433 3178-3180 NNP denotes RA
T4432 3175-3177 IN denotes of
T4431 3162-3174 NN denotes pathogenesis
T4430 3158-3161 DT denotes the
T4429 3153-3157 IN denotes into
T4428 3144-3152 NNS denotes insights
T4427 3140-3143 JJ denotes new
T4426 3132-3139 VB denotes provide
T4425 3126-3131 MD denotes might
T4424 3118-3125 NNS denotes results
T4423 3112-3117 DT denotes These
T4422 3110-3111 . denotes .
T4421 3108-3110 NNP denotes RA
T4420 3105-3107 IN denotes in
T4419 3099-3104 NNP denotes IL-17
T4418 3090-3098 NN denotes cytokine
T4417 3077-3089 JJ denotes inflammatory
T4416 3073-3076 JJ denotes key
T4415 3069-3072 DT denotes the
T4414 3066-3068 IN denotes of
T4413 3051-3065 NN denotes overproduction
T4412 3047-3050 DT denotes the
T4411 3044-3046 IN denotes in
T4410 3035-3043 VBN denotes involved
T4409 3032-3034 VB denotes be
T4408 3026-3031 MD denotes might
T4407 3020-3025 NNP denotes NF-κB
T4406 3016-3019 CC denotes and
T4405 3012-3015 NNP denotes Akt
T4404 3011-3012 VBP denotes /
T4403 3010-3011 -RRB- denotes )
T4402 3006-3010 NNP denotes PI3K
T4401 3005-3006 -LRB- denotes (
T4400 2996-3004 JJ denotes 3-kinase
T4399 2979-2995 NN denotes phosphoinositide
T4398 2969-2978 VBG denotes involving
T4397 2961-2968 NN denotes pathway
T4396 2951-2960 VBG denotes signaling
T4395 2937-2950 JJ denotes intracellular
T4394 2933-2936 DT denotes the
T4393 2928-2932 IN denotes that
T4392 2922-2927 VBD denotes found
T4391 2919-2921 PRP denotes We
T4390 2917-2918 . denotes .
T4389 2910-2917 NN denotes pathway
T4388 2897-2909 NN denotes transduction
T4387 2887-2896 VBG denotes signaling
T4386 2883-2886 PRP$ denotes its
T4385 2879-2882 CC denotes and
T4384 2876-2878 NNP denotes RA
T4383 2871-2875 IN denotes with
T4382 2862-2870 NNS denotes patients
T4381 2859-2861 IN denotes of
T4380 2854-2858 NNP denotes PBMC
T4379 2851-2853 IN denotes in
T4378 2840-2850 NN denotes production
T4377 2834-2839 JJ denotes IL-17
T4376 2822-2833 VB denotes investigate
T4375 2819-2821 TO denotes to
T4374 2811-2818 NNS denotes stimuli
T4373 2803-2810 JJ denotes various
T4372 2798-2802 VBD denotes used
T4371 2795-2797 PRP denotes we
T4370 2789-2794 NN denotes study
T4369 2781-2788 JJ denotes present
T4368 2777-2780 DT denotes the
T4367 2774-2776 IN denotes In
T4366 2772-2773 . denotes .
T4365 2763-2772 JJ denotes uncertain
T4364 2755-2762 VBZ denotes remains
T4363 2744-2754 NN denotes production
T4362 2738-2743 JJ denotes IL-17
T4361 2734-2737 IN denotes for
T4360 2726-2733 NN denotes pathway
T4359 2713-2725 NN denotes transduction
T4358 2706-2712 NN denotes signal
T4357 2692-2705 JJ denotes intracellular
T4356 2688-2691 DT denotes the
T4355 2686-2687 , denotes ,
T4354 2685-2686 NNP denotes ]
T4353 2677-2685 CD denotes 12,15,16
T4352 2676-2677 NNP denotes [
T4351 2668-2675 NNS denotes studies
T4350 2660-2667 JJR denotes earlier
T4349 2657-2659 IN denotes in
T4348 2646-2656 VBN denotes documented
T4347 2641-2645 VBN denotes been
T4346 2637-2640 VBZ denotes has
T4345 2634-2636 NNP denotes RA
T4344 2631-2633 IN denotes in
T4343 2618-2630 NN denotes inflammation
T4342 2612-2617 JJ denotes joint
T4341 2609-2611 IN denotes in
T4340 2603-2608 NNP denotes IL-17
T4339 2600-2602 IN denotes of
T4338 2587-2599 NN denotes contribution
T4337 2583-2586 DT denotes the
T4336 2574-2582 IN denotes Although
T4335 2572-2573 . denotes .
T4334 2571-2572 NNP denotes ]
T4333 2569-2571 CD denotes 14
T4332 2568-2569 NNP denotes [
T4331 2562-2567 NNS denotes cells
T4330 2560-2561 NNP denotes T
T4329 2558-2559 CD denotes +
T4328 2555-2558 CD denotes CD8
T4327 2551-2554 CC denotes and
T4326 2549-2550 NN denotes +
T4325 2546-2549 CD denotes CD4
T4324 2541-2545 DT denotes both
T4323 2536-2540 IN denotes from
T4322 2525-2535 NN denotes production
T4321 2519-2524 JJ denotes IL-17
T4320 2516-2518 IN denotes of
T4319 2508-2515 NN denotes trigger
T4318 2498-2507 JJ denotes efficient
T4317 2495-2497 DT denotes an
T4316 2492-2494 VB denotes be
T4315 2486-2491 MD denotes could
T4314 2480-2485 NN denotes IL-23
T4313 2475-2479 IN denotes that
T4312 2468-2474 VBD denotes showed
T4311 2463-2467 RB denotes also
T4310 2452-2462 NNS denotes colleagues
T4309 2448-2451 CC denotes and
T4308 2441-2447 NNP denotes Happel
T4307 2439-2440 , denotes ,
T4306 2431-2439 RB denotes Recently
T4305 2429-2430 . denotes .
T4304 2428-2429 NNP denotes ]
T4303 2426-2428 CD denotes 13
T4302 2425-2426 NNP denotes [
T4301 2416-2424 NNS denotes pathways
T4300 2406-2415 JJ denotes sensitive
T4299 2398-2405 JJ denotes steroid
T4298 2394-2397 CC denotes and
T3974 692-695 DT denotes the
T3973 679-691 VBG denotes infiltrating
T3972 668-678 NN denotes population
T3971 663-667 NN denotes cell
T3970 655-662 JJS denotes largest
T3969 651-654 DT denotes the
T3968 647-650 VBP denotes are
T3967 642-646 PRP denotes they
T3966 634-641 IN denotes because
T3965 623-633 JJ denotes undisputed
T3964 619-622 VBD denotes was
T3963 616-618 NNP denotes RA
T3962 613-615 IN denotes as
T3961 608-612 JJ denotes such
T3960 600-607 NN denotes disease
T3959 589-599 JJ denotes autoimmune
T3958 586-588 IN denotes of
T3957 573-585 NN denotes pathogenesis
T3956 569-572 DT denotes the
T3955 566-568 IN denotes in
T3954 560-565 NNS denotes cells
T3953 558-559 NNP denotes T
T3952 555-557 IN denotes of
T3951 547-554 NN denotes primacy
T3950 543-546 DT denotes the
T3949 541-542 , denotes ,
T3948 538-541 RB denotes ago
T3947 531-537 NN denotes decade
T3946 529-530 DT denotes a
T3945 524-528 IN denotes over
T3944 517-523 JJ denotes little
T3943 515-516 DT denotes A
T3942 513-514 . denotes .
T3941 512-513 NN denotes ]
T3940 511-512 CD denotes 2
T3939 510-511 JJ denotes [
T3938 497-509 NNS denotes applications
T3937 485-496 JJ denotes therapeutic
T3936 481-484 JJ denotes new
T3935 478-480 IN denotes of
T3934 466-477 NN denotes development
T3933 462-465 DT denotes the
T3932 459-461 IN denotes in
T3931 453-458 NN denotes issue
T3930 443-452 JJ denotes important
T3929 439-442 DT denotes the
T3928 434-438 VBN denotes been
T3927 430-433 VBZ denotes has
T3926 420-429 NNS denotes cytokines
T3925 407-419 JJ denotes inflammatory
T3924 403-406 JJ denotes key
T3923 400-402 IN denotes of
T3922 391-399 NN denotes blockade
T3921 387-390 DT denotes the
T3920 382-386 IN denotes that
T3919 374-381 VBP denotes suggest
T3918 371-373 CD denotes -1
T3917 370-371 -RRB- denotes )
T3916 368-370 NNP denotes IL
T3915 367-368 -LRB- denotes (
T3914 355-366 NN denotes interleukin
T3913 351-354 CC denotes and
T3912 349-350 -RRB- denotes )
T3911 348-349 VBN denotes α
T3910 347-348 : denotes -
T3909 346-347 -RRB- denotes )
T3908 343-346 NNP denotes TNF
T3907 342-343 -LRB- denotes (
T3906 335-341 NN denotes factor
T3905 326-334 NN denotes necrosis
T3904 320-325 NN denotes tumor
T3903 317-319 IN denotes of
T3902 306-316 NNS denotes inhibitors
T3901 301-305 IN denotes with
T3900 292-300 VBN denotes obtained
T3899 283-291 NNS denotes benefits
T3898 274-282 JJ denotes clinical
T3897 264-273 JJ denotes favorable
T3896 260-263 DT denotes The
T3895 258-259 . denotes .
T3894 257-258 NNP denotes ]
T3893 256-257 CD denotes 1
T3892 255-256 NNP denotes [
T3891 252-254 NNP denotes RA
T3890 249-251 IN denotes in
T3889 242-248 NNS denotes joints
T3888 239-241 IN denotes of
T3887 227-238 NN denotes destruction
T3886 223-226 DT denotes the
T3885 220-222 IN denotes in
T3884 210-219 JJ denotes important
T3883 207-209 VB denotes be
T3882 204-206 TO denotes to
T3881 198-203 VBN denotes known
T3880 194-197 VBP denotes are
T3879 188-193 NNS denotes cells
T3878 182-187 DT denotes these
T3877 177-181 IN denotes from
T3876 168-176 VBN denotes released
T3875 158-167 NNS denotes cytokines
T3874 142-157 JJ denotes Proinflammatory
T3873 140-141 . denotes .
T3872 129-140 NN denotes hyperplasia
T3871 120-128 JJ denotes synovial
T3870 116-119 CC denotes and
T3869 114-115 , denotes ,
T3868 109-114 JJ denotes joint
T3867 105-108 DT denotes the
T3866 100-104 IN denotes into
T3865 94-99 NNS denotes cells
T3864 92-93 NNP denotes T
T3863 88-91 CC denotes and
T3862 76-87 NNS denotes macrophages
T3861 73-75 IN denotes of
T3860 59-72 NNS denotes infiltrations
T3859 56-58 IN denotes by
T3858 42-55 VBN denotes characterized
T3857 39-41 VBZ denotes is
T3856 37-38 -RRB- denotes )
T3855 35-37 NNP denotes RA
T3854 34-35 -LRB- denotes (
T3853 24-33 NNS denotes arthritis
T3852 13-23 JJ denotes Rheumatoid
T4164 1688-1697 NN denotes induction
T4163 1684-1687 DT denotes the
T4162 1681-1683 IN denotes by
T4161 1670-1680 NN denotes resorption
T4160 1665-1669 NN denotes bone
T4159 1652-1664 JJ denotes osteoclastic
T4158 1643-1651 VB denotes activate
T4157 1638-1642 RB denotes also
T4156 1634-1637 MD denotes can
T4155 1628-1633 NNP denotes IL-17
T4154 1623-1627 IN denotes that
T4153 1610-1622 VBD denotes demonstrated
T4152 1597-1609 NNS denotes observations
T4151 1590-1596 JJ denotes Recent
T4150 1588-1589 . denotes .
T4149 1587-1588 NNP denotes ]
T4148 1586-1587 CD denotes 6
T4147 1585-1586 NNP denotes [
T4146 1579-1584 NNS denotes cells
T4145 1577-1578 NNP denotes T
T4144 1574-1576 IN denotes by
T4143 1565-1573 VBN denotes produced
T4142 1562-1564 VBZ denotes is
T4141 1559-1561 PRP denotes it
T4140 1557-1558 , denotes ,
T4139 1551-1557 JJ denotes second
T4138 1549-1550 : denotes ;
T4137 1539-1549 NNS denotes properties
T4136 1523-1538 JJ denotes proinflammatory
T4135 1519-1522 VBZ denotes has
T4134 1513-1518 NNP denotes IL-17
T4133 1511-1512 , denotes ,
T4132 1507-1511 NNP denotes IL-1
T4131 1503-1506 CC denotes and
T4130 1497-1502 NNP denotes TNF-α
T4129 1494-1496 TO denotes to
T4128 1484-1493 RB denotes similarly
T4127 1482-1483 , denotes ,
T4126 1477-1482 RB denotes first
T4125 1475-1476 : denotes :
T4124 1468-1475 NNS denotes reasons
T4123 1462-1467 JJ denotes major
T4122 1458-1461 CD denotes two
T4121 1454-1457 IN denotes for
T4120 1445-1453 NN denotes interest
T4119 1442-1444 IN denotes of
T4118 1439-1441 VBZ denotes is
T4117 1430-1438 NN denotes cytokine
T4116 1425-1429 DT denotes This
T4115 1423-1424 . denotes .
T4114 1422-1423 NNP denotes ]
T4113 1421-1422 CD denotes 5
T4112 1420-1421 VBP denotes [
T4111 1408-1419 NNS denotes fibroblasts
T4110 1405-1407 IN denotes by
T4109 1400-1404 NNP denotes IL-8
T4108 1396-1399 CC denotes and
T4107 1391-1395 NNP denotes IL-6
T4106 1384-1390 VB denotes induce
T4105 1380-1383 MD denotes can
T4104 1374-1379 WDT denotes which
T4103 1372-1373 , denotes ,
T4102 1367-1372 NNS denotes cells
T4101 1365-1366 NNP denotes T
T4100 1355-1364 VBN denotes activated
T4099 1352-1354 IN denotes by
T4098 1345-1351 RB denotes mainly
T4097 1336-1344 VBD denotes secreted
T4096 1326-1335 NNS denotes cytokines
T4095 1313-1325 JJ denotes inflammatory
T4094 1309-1312 DT denotes the
T4093 1306-1308 IN denotes of
T4092 1302-1305 CD denotes one
T4091 1299-1301 VBZ denotes is
T4090 1293-1298 NNP denotes IL-17
T4089 1291-1292 . denotes .
T4088 1284-1291 NNS denotes aspects
T4087 1274-1283 JJ denotes different
T4086 1271-1273 IN denotes in
T4085 1260-1270 VBN denotes elucidated
T4084 1257-1259 VB denotes be
T4083 1254-1256 TO denotes to
T4082 1248-1253 VBZ denotes needs
T4081 1242-1247 NNS denotes cells
T4080 1240-1241 NNP denotes T
T4079 1237-1239 IN denotes of
T4078 1232-1236 NN denotes role
T4077 1228-1231 DT denotes the
T4076 1226-1227 , denotes ,
T4075 1225-1226 NNP denotes ]
T4074 1224-1225 CD denotes 4
T4073 1223-1224 NNP denotes [
T4072 1220-1222 NNP denotes RA
T4071 1217-1219 IN denotes in
T4070 1207-1216 NNS denotes cytokines
T4069 1205-1206 -RRB- denotes )
T4068 1202-1205 NN denotes Th1
T4067 1201-1202 -LRB- denotes (
T4066 1199-1200 CD denotes 1
T4065 1194-1198 NN denotes type
T4064 1187-1193 NN denotes helper
T4063 1185-1186 NNP denotes T
T4062 1182-1184 IN denotes of
T4061 1174-1181 NN denotes skewing
T4060 1170-1173 DT denotes the
T4059 1166-1169 CC denotes and
T4058 1164-1165 , denotes ,
T4057 1156-1164 NN denotes collagen
T4056 1153-1155 NNP denotes II
T4055 1148-1152 NN denotes type
T4054 1145-1147 TO denotes to
T4053 1134-1144 RB denotes especially
T4052 1132-1133 , denotes ,
T4051 1127-1132 NNS denotes cells
T4050 1125-1126 NNP denotes T
T4049 1116-1124 JJ denotes specific
T4048 1108-1115 NN denotes antigen
T4047 1105-1107 IN denotes of
T4046 1091-1104 NN denotes proliferation
T4045 1082-1090 JJ denotes enhanced
T4044 1078-1081 DT denotes the
T4043 1065-1077 VBN denotes demonstrated
T4042 1057-1064 RB denotes already
T4041 1052-1056 VBP denotes have
T4040 1049-1051 PRP denotes we
T4039 1041-1048 IN denotes Because
T4038 1039-1040 . denotes .
T4037 1038-1039 NNP denotes ]
T4036 1037-1038 CD denotes 3
T4035 1036-1037 NNP denotes [
T4034 1033-1035 NNP denotes RA
T4033 1030-1032 IN denotes of
T4032 1017-1029 NN denotes pathogenesis
T4031 1013-1016 DT denotes the
T4030 1010-1012 IN denotes in
T4029 1004-1009 NNS denotes cells
T4028 1002-1003 NNP denotes T
T4027 999-1001 IN denotes of
T4026 994-998 NN denotes role
T4025 990-993 DT denotes the
T4024 979-989 VBN denotes questioned
T4023 975-978 VBZ denotes has
T4022 967-974 NN denotes paradox
T4021 962-966 DT denotes This
T4020 960-961 . denotes .
T4019 952-960 NN denotes synovium
T4018 941-951 JJ denotes rheumatoid
T4017 938-940 IN denotes in
T4016 929-937 JJ denotes abundant
T4015 924-928 VBD denotes were
T4014 918-923 NNP denotes TNF-α
T4013 914-917 CC denotes and
T4012 908-913 NNP denotes IL-18
T4011 906-907 , denotes ,
T4010 901-906 NNP denotes IL-15
T4009 899-900 , denotes ,
T4008 895-899 NNP denotes IL-6
T4007 893-894 , denotes ,
T4006 889-893 NNP denotes IL-1
T4005 879-888 VBG denotes including
T4004 869-878 NNS denotes cytokines
T4003 858-868 NN denotes fibroblast
T4002 854-857 CC denotes and
T4001 843-853 NN denotes macrophage
T4000 835-842 IN denotes whereas
T3999 833-834 , denotes ,
T3998 831-833 NNP denotes RA
T3997 828-830 IN denotes of
T3996 821-827 NNS denotes joints
T3995 817-820 DT denotes the
T3994 814-816 IN denotes in
T3993 801-813 NN denotes interferon-γ
T3992 797-800 CC denotes and
T3991 792-796 NN denotes IL-2
T3990 789-791 IN denotes as
T3989 784-788 JJ denotes such
T3988 774-783 NNS denotes cytokines
T3987 761-773 JJ denotes cell-derived
T3986 759-760 NNP denotes T
T3985 756-758 IN denotes of
T3984 748-755 NN denotes paucity
T3983 735-747 VBD denotes demonstrated
T3982 727-734 NNS denotes studies
T3981 724-726 IN denotes of
T3980 717-723 NN denotes series
T3979 715-716 DT denotes a
T3978 713-714 , denotes ,
T3977 706-713 RB denotes However
T3976 704-705 . denotes .
T3975 696-704 NN denotes synovium
T4297 2381-2393 NN denotes cyclosporine
T4296 2378-2380 IN denotes by
T4295 2376-2377 -RRB- denotes )
T4294 2372-2376 NNP denotes PBMC
T4293 2371-2372 -LRB- denotes (
T4292 2365-2370 NNS denotes cells
T4291 2353-2364 NN denotes mononuclear
T4290 2347-2352 NN denotes blood
T4289 2336-2346 JJ denotes peripheral
T4288 2333-2335 NNP denotes RA
T4287 2330-2332 IN denotes in
T4286 2319-2329 NN denotes production
T4285 2313-2318 JJ denotes IL-17
T4284 2310-2312 IN denotes of
T4283 2302-2309 NN denotes trigger
T4282 2292-2301 JJ denotes important
T4281 2289-2291 DT denotes an
T4280 2286-2288 VB denotes be
T4279 2283-2285 TO denotes to
T4278 2274-2282 VBN denotes reported
T4277 2269-2273 VBN denotes been
T4276 2265-2268 VBZ denotes has
T4275 2263-2264 , denotes ,
T4274 2252-2263 NNS denotes macrophages
T4273 2242-2251 VBN denotes activated
T4272 2237-2241 IN denotes from
T4271 2228-2236 VBN denotes secreted
T4270 2226-2227 , denotes ,
T4269 2221-2226 CD denotes IL-15
T4268 2219-2220 . denotes .
T4267 2218-2219 NNP denotes ]
T4266 2213-2218 CD denotes 11,12
T4265 2212-2213 NNP denotes [
T4264 2203-2211 NN denotes synovium
T4263 2199-2202 DT denotes the
T4262 2196-2198 IN denotes in
T4261 2190-2195 NNS denotes cells
T4260 2188-2189 NNP denotes T
T4259 2186-2187 NNP denotes +
T4258 2183-2186 NNP denotes CD4
T4257 2180-2182 IN denotes by
T4256 2171-2179 VBN denotes produced
T4255 2167-2170 VBD denotes was
T4254 2164-2166 PRP denotes it
T4253 2160-2163 CC denotes and
T4252 2158-2159 , denotes ,
T4251 2157-2158 -RRB- denotes )
T4250 2155-2157 NNP denotes OA
T4249 2154-2155 -LRB- denotes (
T4248 2139-2153 NNS denotes osteoarthritis
T4247 2134-2138 IN denotes with
T4246 2125-2133 NNS denotes patients
T4245 2122-2124 IN denotes in
T4244 2117-2121 IN denotes than
T4243 2114-2116 NNP denotes RA
T4242 2109-2113 IN denotes with
T4241 2100-2108 NNS denotes patients
T4240 2097-2099 IN denotes in
T4239 2090-2096 JJR denotes higher
T4238 2076-2089 RB denotes significantly
T4237 2071-2075 VBD denotes were
T4236 2064-2070 NNS denotes fluids
T4235 2055-2063 JJ denotes synovial
T4234 2052-2054 IN denotes in
T4233 2046-2051 NNP denotes IL-17
T4232 2043-2045 IN denotes of
T4231 2036-2042 NNS denotes Levels
T4230 2034-2035 . denotes .
T4229 2033-2034 NNP denotes ]
T4228 2029-2033 CD denotes 8-10
T4227 2028-2029 NNP denotes [
T4226 2022-2027 NNS denotes cells
T4225 2012-2021 JJ denotes dendritic
T4224 2008-2011 DT denotes the
T4223 1999-2007 VB denotes activate
T4222 1995-1998 CC denotes and
T4221 1981-1994 VB denotes differentiate
T4220 1978-1980 TO denotes to
T4219 1970-1977 NN denotes ability
T4218 1966-1969 DT denotes the
T4217 1962-1965 VBZ denotes has
T4216 1958-1961 CC denotes and
T4215 1956-1957 , denotes ,
T4214 1944-1956 NNS denotes chondrocytes
T4213 1941-1943 IN denotes by
T4212 1935-1940 NN denotes oxide
T4211 1928-1934 JJ denotes nitric
T4210 1924-1927 CC denotes and
T4209 1921-1923 CD denotes E2
T4208 1907-1920 NN denotes prostaglandin
T4207 1904-1906 IN denotes of
T4206 1900-1903 CC denotes and
T4205 1898-1899 , denotes ,
T4204 1886-1898 NNS denotes synoviocytes
T4203 1883-1885 IN denotes by
T4202 1876-1882 NN denotes factor
T4201 1865-1875 JJ denotes inhibitory
T4200 1856-1864 NN denotes leukemia
T4199 1852-1855 CC denotes and
T4198 1847-1851 NN denotes IL-6
T4197 1844-1846 IN denotes of
T4196 1833-1843 NN denotes production
T4195 1829-1832 DT denotes the
T4194 1818-1828 VBZ denotes stimulates
T4193 1813-1817 RB denotes also
T4192 1810-1812 PRP denotes It
T4191 1808-1809 . denotes .
T4190 1807-1808 NNP denotes ]
T4189 1806-1807 CD denotes 7
T4188 1805-1806 NNP denotes [
T4187 1802-1804 NNP denotes RA
T4186 1799-1801 IN denotes in
T4185 1791-1798 NN denotes erosion
T4184 1786-1790 NN denotes bony
T4183 1783-1785 IN denotes in
T4182 1774-1782 VBN denotes involved
T4181 1771-1773 VBZ denotes is
T4180 1765-1770 WDT denotes which
T4179 1763-1764 , denotes ,
T4178 1762-1763 -RRB- denotes )
T4177 1756-1762 NN denotes ligand
T4176 1754-1755 NNP denotes ]
T4175 1749-1754 NNP denotes NF-κB
T4174 1748-1749 NNP denotes [
T4173 1745-1747 NNP denotes κB
T4172 1738-1744 NN denotes factor
T4171 1730-1737 JJ denotes nuclear
T4170 1727-1729 IN denotes of
T4169 1717-1726 NN denotes activator
T4168 1708-1716 NN denotes receptor
T4167 1707-1708 -LRB- denotes (
T4166 1701-1706 NNP denotes RANKL
T4165 1698-1700 IN denotes of
R1821 T3852 T3853 amod Rheumatoid,arthritis
R1822 T3853 T3858 nsubjpass arthritis,characterized
R1823 T3854 T3853 punct (,arthritis
R1824 T3855 T3853 appos RA,arthritis
R1828 T3856 T3853 punct ),arthritis
R1829 T3857 T3858 auxpass is,characterized
R1832 T3858 T3858 ROOT characterized,characterized
R1833 T3859 T3858 agent by,characterized
R1836 T3860 T3859 pobj infiltrations,by
R1838 T3861 T3860 prep of,infiltrations
R1841 T3862 T3861 pobj macrophages,of
R1843 T3863 T3862 cc and,macrophages
R1845 T3864 T3865 compound T,cells
R1846 T3865 T3862 conj cells,macrophages
R1847 T3866 T3858 prep into,characterized
R1848 T3867 T3868 det the,joint
R1849 T3868 T3872 amod joint,hyperplasia
R1850 T3869 T3868 punct ",",joint
R1851 T3948 T3964 advmod ago,was
R1852 T3870 T3868 cc and,joint
R1853 T3949 T3964 punct ",",was
R1854 T3950 T3951 det the,primacy
R1855 T3871 T3868 conj synovial,joint
R1856 T3951 T3964 nsubj primacy,was
R1857 T3952 T3951 prep of,primacy
R1858 T3872 T3866 pobj hyperplasia,into
R1859 T3953 T3954 compound T,cells
R1860 T3954 T3952 pobj cells,of
R1861 T3873 T3858 punct .,characterized
R1862 T3955 T3951 prep in,primacy
R1863 T3956 T3957 det the,pathogenesis
R1864 T3957 T3955 pobj pathogenesis,in
R1865 T3874 T3875 amod Proinflammatory,cytokines
R1866 T3958 T3957 prep of,pathogenesis
R1867 T3959 T3960 amod autoimmune,disease
R1868 T3960 T3958 pobj disease,of
R1869 T3875 T3881 nsubjpass cytokines,known
R1870 T3961 T3962 amod such,as
R1871 T3962 T3957 prep as,pathogenesis
R1872 T3963 T3964 nsubj RA,was
R1873 T3876 T3875 acl released,cytokines
R1874 T3964 T3964 ROOT was,was
R1875 T3965 T3964 acomp undisputed,was
R1876 T3966 T3968 mark because,are
R1877 T3967 T3968 nsubj they,are
R1878 T3877 T3876 prep from,released
R1879 T3968 T3964 advcl are,was
R1880 T3878 T3879 det these,cells
R1881 T3969 T3972 det the,population
R1882 T3970 T3972 amod largest,population
R1883 T3879 T3877 pobj cells,from
R1884 T3971 T3972 compound cell,population
R1885 T3972 T3968 attr population,are
R1886 T3973 T3972 acl infiltrating,population
R1887 T3880 T3881 auxpass are,known
R1888 T3974 T3975 det the,synovium
R1889 T3975 T3973 dobj synovium,infiltrating
R1890 T3976 T3964 punct .,was
R1891 T3881 T3881 ROOT known,known
R1892 T3977 T3983 advmod However,demonstrated
R1893 T3978 T3983 punct ",",demonstrated
R1894 T3882 T3883 aux to,be
R1895 T3979 T3980 det a,series
R1896 T3980 T3983 nsubj series,demonstrated
R1897 T3981 T3980 prep of,series
R1898 T3883 T3881 xcomp be,known
R1899 T3982 T3981 pobj studies,of
R1900 T3983 T3983 ROOT demonstrated,demonstrated
R1901 T3884 T3883 acomp important,be
R1902 T3984 T3983 dobj paucity,demonstrated
R1903 T3985 T3984 prep of,paucity
R1904 T3986 T3988 nmod T,cytokines
R1905 T3885 T3883 prep in,be
R1906 T3987 T3988 amod cell-derived,cytokines
R1907 T3988 T3985 pobj cytokines,of
R1908 T3989 T3990 amod such,as
R1909 T3886 T3887 det the,destruction
R1910 T3990 T3988 prep as,cytokines
R1911 T3991 T3990 pobj IL-2,as
R1912 T3992 T3991 cc and,IL-2
R1913 T3887 T3885 pobj destruction,in
R1914 T3993 T3991 conj interferon-γ,IL-2
R1915 T3994 T3983 prep in,demonstrated
R1916 T3995 T3996 det the,joints
R1917 T3996 T3994 pobj joints,in
R1918 T3888 T3887 prep of,destruction
R1919 T3997 T3996 prep of,joints
R1920 T3998 T3997 pobj RA,of
R1921 T3999 T3983 punct ",",demonstrated
R1922 T3889 T3888 pobj joints,of
R1923 T3890 T3887 prep in,destruction
R1924 T4000 T4015 mark whereas,were
R1925 T3891 T3892 compound RA,[
R1926 T4001 T4015 nsubj macrophage,were
R1927 T4002 T4001 cc and,macrophage
R1928 T4003 T4001 conj fibroblast,macrophage
R1929 T3892 T3890 pobj [,in
R1930 T4004 T4001 conj cytokines,macrophage
R1931 T4005 T4004 prep including,cytokines
R1932 T4006 T4005 pobj IL-1,including
R1933 T4007 T4006 punct ",",IL-1
R1934 T3893 T3894 nummod 1,]
R1935 T4008 T4006 conj IL-6,IL-1
R1936 T4009 T4008 punct ",",IL-6
R1937 T4010 T4008 conj IL-15,IL-6
R1938 T4011 T4010 punct ",",IL-15
R1939 T3894 T3892 appos ],[
R1940 T4012 T4010 conj IL-18,IL-15
R1941 T4013 T4012 cc and,IL-18
R1942 T3895 T3881 punct .,known
R1943 T4014 T4012 conj TNF-α,IL-18
R1944 T4015 T3983 advcl were,demonstrated
R1945 T4016 T4015 acomp abundant,were
R1946 T4017 T4016 prep in,abundant
R1947 T3896 T3899 det The,benefits
R1948 T4018 T4019 amod rheumatoid,synovium
R1949 T4019 T4017 pobj synovium,in
R1950 T4020 T3983 punct .,demonstrated
R1951 T3897 T3899 amod favorable,benefits
R1952 T4021 T4022 det This,paradox
R1953 T4022 T4024 nsubj paradox,questioned
R1954 T4023 T4024 aux has,questioned
R1955 T3898 T3899 amod clinical,benefits
R1956 T4024 T4024 ROOT questioned,questioned
R1957 T4025 T4026 det the,role
R1958 T3899 T3911 nsubj benefits,α
R1959 T4026 T4024 dobj role,questioned
R1960 T4027 T4026 prep of,role
R1961 T4028 T4029 compound T,cells
R1962 T3900 T3899 acl obtained,benefits
R1963 T4029 T4027 pobj cells,of
R1964 T4030 T4026 prep in,role
R1965 T4031 T4032 det the,pathogenesis
R1966 T3901 T3900 prep with,obtained
R1967 T4032 T4030 pobj pathogenesis,in
R1968 T4033 T4032 prep of,pathogenesis
R1969 T3902 T3901 pobj inhibitors,with
R1970 T4034 T4035 compound RA,[
R1971 T4035 T4033 pobj [,of
R1972 T4036 T4037 nummod 3,]
R1973 T3903 T3902 prep of,inhibitors
R1974 T4037 T4032 appos ],pathogenesis
R1975 T4038 T4024 punct .,questioned
R1976 T4039 T4043 mark Because,demonstrated
R1977 T3904 T3905 compound tumor,necrosis
R1978 T4040 T4043 nsubj we,demonstrated
R1979 T4041 T4043 aux have,demonstrated
R1980 T4042 T4043 advmod already,demonstrated
R1981 T4043 T4043 ROOT demonstrated,demonstrated
R1982 T4044 T4046 det the,proliferation
R1983 T3905 T3906 compound necrosis,factor
R1984 T3906 T3903 pobj factor,of
R1985 T3907 T3908 punct (,TNF
R1986 T4045 T4046 amod enhanced,proliferation
R1987 T4046 T4043 dobj proliferation,demonstrated
R1988 T3908 T3906 appos TNF,factor
R1989 T4047 T4046 prep of,proliferation
R1990 T3909 T3900 punct ),obtained
R1991 T4048 T4047 pobj antigen,of
R1992 T4049 T4051 amod specific,cells
R1993 T3910 T3899 punct -,benefits
R1994 T4050 T4051 compound T,cells
R1995 T4051 T4047 pobj cells,of
R1996 T4052 T4046 punct ",",proliferation
R1997 T3911 T3911 ROOT α,α
R1998 T4053 T4055 advmod especially,type
R1999 T4054 T4055 aux to,type
R2000 T3912 T3911 punct ),α
R2001 T4055 T4082 advcl type,needs
R2002 T4056 T4057 compound II,collagen
R2003 T4057 T4055 dobj collagen,type
R2004 T3913 T3911 cc and,α
R2005 T4058 T4055 punct ",",type
R2006 T4059 T4055 cc and,type
R2007 T4060 T4061 det the,skewing
R2008 T3914 T3919 nsubj interleukin,suggest
R2009 T4061 T4055 conj skewing,type
R2010 T4062 T4061 prep of,skewing
R2011 T4063 T4064 compound T,helper
R2012 T3915 T3916 punct (,IL
R2013 T4064 T4065 compound helper,type
R2014 T4065 T4061 conj type,skewing
R2015 T3916 T3914 appos IL,interleukin
R2016 T4066 T4065 nummod 1,type
R2017 T4067 T4068 punct (,Th1
R2018 T4068 T4065 appos Th1,type
R2019 T3917 T3918 punct ),-1
R2020 T4069 T4068 punct ),Th1
R2021 T4070 T4065 conj cytokines,type
R2022 T4071 T4070 prep in,cytokines
R2023 T3918 T3919 nsubj -1,suggest
R2024 T4072 T4073 compound RA,[
R2025 T4073 T4071 pobj [,in
R2026 T3919 T3911 conj suggest,α
R2027 T4074 T4075 nummod 4,]
R2028 T4075 T4082 nsubj ],needs
R2029 T4076 T4075 punct ",",]
R2030 T4077 T4078 det the,role
R2031 T4078 T4075 appos role,]
R2032 T4079 T4078 prep of,role
R2033 T3920 T3928 mark that,been
R2034 T4080 T4081 compound T,cells
R2035 T4081 T4079 pobj cells,of
R2036 T4082 T4043 conj needs,demonstrated
R2037 T3921 T3922 det the,blockade
R2038 T4083 T4085 aux to,elucidated
R2039 T4084 T4085 auxpass be,elucidated
R2040 T4085 T4082 xcomp elucidated,needs
R2041 T3922 T3928 nsubj blockade,been
R2042 T4086 T4085 prep in,elucidated
R2043 T4087 T4088 amod different,aspects
R2044 T4088 T4086 pobj aspects,in
R2045 T3923 T3922 prep of,blockade
R2046 T4089 T4082 punct .,needs
R2047 T4090 T4091 nsubj IL-17,is
R2048 T3924 T3926 amod key,cytokines
R2049 T4091 T4091 ROOT is,is
R2050 T4092 T4091 attr one,is
R2051 T4093 T4092 prep of,one
R2052 T3925 T3926 amod inflammatory,cytokines
R2053 T4094 T4096 det the,cytokines
R2054 T4095 T4096 amod inflammatory,cytokines
R2055 T4096 T4093 pobj cytokines,of
R2056 T3926 T3923 pobj cytokines,of
R2057 T4097 T4092 acl secreted,one
R2058 T4098 T4099 advmod mainly,by
R2059 T4099 T4097 agent by,secreted
R2060 T3927 T3928 aux has,been
R2061 T4100 T4102 amod activated,cells
R2062 T4101 T4102 compound T,cells
R2063 T4102 T4099 pobj cells,by
R2064 T3928 T3919 ccomp been,suggest
R2065 T4103 T4102 punct ",",cells
R2066 T4104 T4106 nsubj which,induce
R2067 T4105 T4106 aux can,induce
R2068 T3929 T3931 det the,issue
R2069 T4106 T4102 relcl induce,cells
R2070 T4107 T4106 dobj IL-6,induce
R2071 T3930 T3931 amod important,issue
R2072 T4108 T4107 cc and,IL-6
R2073 T4109 T4107 conj IL-8,IL-6
R2074 T4110 T4106 prep by,induce
R2075 T3931 T3928 attr issue,been
R2076 T4111 T4110 pobj fibroblasts,by
R2077 T4112 T4114 nmod [,]
R2078 T4113 T4114 nummod 5,]
R2079 T3932 T3931 prep in,issue
R2080 T4114 T4106 npadvmod ],induce
R2081 T3933 T3934 det the,development
R2082 T4115 T4091 punct .,is
R2083 T4116 T4117 det This,cytokine
R2084 T3934 T3932 pobj development,in
R2085 T4117 T4118 nsubj cytokine,is
R2086 T4118 T4143 ccomp is,produced
R2087 T3935 T3934 prep of,development
R2088 T4119 T4118 prep of,is
R2089 T4120 T4119 pobj interest,of
R2090 T4121 T4118 prep for,is
R2091 T3936 T3938 amod new,applications
R2092 T4122 T4124 nummod two,reasons
R2093 T4123 T4124 amod major,reasons
R2094 T4124 T4121 pobj reasons,for
R2095 T3937 T3938 amod therapeutic,applications
R2096 T4125 T4124 punct :,reasons
R2097 T3938 T3935 pobj applications,of
R2098 T4126 T4129 advmod first,to
R2099 T4127 T4129 punct ",",to
R2100 T3939 T3941 amod [,]
R2101 T4128 T4129 advmod similarly,to
R2102 T4129 T4118 prep to,is
R2103 T4130 T4129 pobj TNF-α,to
R2104 T3940 T3941 nummod 2,]
R2105 T4131 T4130 cc and,TNF-α
R2106 T4132 T4130 conj IL-1,TNF-α
R2107 T3941 T3931 conj ],issue
R2108 T4133 T4135 punct ",",has
R2109 T4134 T4135 nsubj IL-17,has
R2110 T4135 T4143 ccomp has,produced
R2111 T3942 T3919 punct .,suggest
R2112 T4136 T4137 amod proinflammatory,properties
R2113 T4137 T4135 dobj properties,has
R2114 T4138 T4143 punct ;,produced
R2115 T3943 T3944 det A,little
R2116 T4139 T4143 advmod second,produced
R2117 T4140 T4143 punct ",",produced
R2118 T4141 T4143 nsubjpass it,produced
R2119 T3944 T3948 npadvmod little,ago
R2120 T3945 T3946 quantmod over,a
R2121 T3946 T3947 nummod a,decade
R2122 T3947 T3948 npadvmod decade,ago
R2123 T4142 T4143 auxpass is,produced
R2124 T4143 T4143 ROOT produced,produced
R2125 T4239 T4237 acomp higher,were
R2126 T4144 T4143 agent by,produced
R2127 T4145 T4146 compound T,cells
R2128 T4146 T4144 pobj cells,by
R2129 T4147 T4149 nmod [,]
R2130 T4148 T4149 nummod 6,]
R2131 T4149 T4146 appos ],cells
R2132 T4150 T4143 punct .,produced
R2133 T4151 T4152 amod Recent,observations
R2134 T4240 T4237 prep in,were
R2135 T4152 T4153 nsubj observations,demonstrated
R2136 T4153 T4153 ROOT demonstrated,demonstrated
R2137 T4154 T4158 mark that,activate
R2138 T4241 T4240 pobj patients,in
R2139 T4155 T4158 nsubj IL-17,activate
R2140 T4242 T4241 prep with,patients
R2141 T4156 T4158 aux can,activate
R2142 T4157 T4158 advmod also,activate
R2143 T4158 T4153 ccomp activate,demonstrated
R2144 T4159 T4161 amod osteoclastic,resorption
R2145 T4243 T4242 pobj RA,with
R2146 T4160 T4161 compound bone,resorption
R2147 T4161 T4158 dobj resorption,activate
R2148 T4162 T4158 prep by,activate
R2149 T4244 T4237 prep than,were
R2150 T4163 T4164 det the,induction
R2151 T4164 T4162 pobj induction,by
R2152 T4165 T4164 prep of,induction
R2153 T4245 T4244 prep in,than
R2154 T4166 T4165 pobj RANKL,of
R2155 T4167 T4169 punct (,activator
R2156 T4168 T4169 compound receptor,activator
R2157 T4246 T4245 pobj patients,in
R2158 T4169 T4166 appos activator,RANKL
R2159 T4170 T4169 prep of,activator
R2160 T4171 T4172 amod nuclear,factor
R2161 T4247 T4246 prep with,patients
R2162 T4172 T4170 pobj factor,of
R2163 T4173 T4177 compound κB,ligand
R2164 T4174 T4177 compound [,ligand
R2165 T4248 T4247 pobj osteoarthritis,with
R2166 T4175 T4177 compound NF-κB,ligand
R2167 T4176 T4177 compound ],ligand
R2168 T4177 T4172 appos ligand,factor
R2169 T4249 T4248 punct (,osteoarthritis
R2170 T4178 T4177 punct ),ligand
R2171 T4179 T4172 punct ",",factor
R2172 T4180 T4182 nsubjpass which,involved
R2173 T4250 T4248 appos OA,osteoarthritis
R2174 T4181 T4182 auxpass is,involved
R2175 T4182 T4172 relcl involved,factor
R2176 T4183 T4182 prep in,involved
R2177 T4251 T4248 punct ),osteoarthritis
R2178 T4184 T4185 amod bony,erosion
R2179 T4185 T4183 pobj erosion,in
R2180 T4252 T4237 punct ",",were
R2181 T4186 T4185 prep in,erosion
R2182 T4187 T4188 compound RA,[
R2183 T4188 T4186 pobj [,in
R2184 T4189 T4190 nummod 7,]
R2185 T4190 T4166 conj ],RANKL
R2186 T4191 T4153 punct .,demonstrated
R2187 T4253 T4237 cc and,were
R2188 T4192 T4194 nsubj It,stimulates
R2189 T4193 T4194 advmod also,stimulates
R2190 T4194 T4194 ROOT stimulates,stimulates
R2191 T4195 T4196 det the,production
R2192 T4254 T4256 nsubjpass it,produced
R2193 T4196 T4194 dobj production,stimulates
R2194 T4197 T4196 prep of,production
R2195 T4198 T4197 pobj IL-6,of
R2196 T4255 T4256 auxpass was,produced
R2197 T4199 T4198 cc and,IL-6
R2198 T4200 T4202 nmod leukemia,factor
R2199 T4201 T4202 amod inhibitory,factor
R2200 T4256 T4237 conj produced,were
R2201 T4202 T4196 conj factor,production
R2202 T4257 T4256 agent by,produced
R2203 T4203 T4196 prep by,production
R2204 T4258 T4261 compound CD4,cells
R2205 T4204 T4203 pobj synoviocytes,by
R2206 T4205 T4194 punct ",",stimulates
R2207 T4259 T4261 compound +,cells
R2208 T4206 T4194 cc and,stimulates
R2209 T4207 T4194 conj of,stimulates
R2210 T4208 T4207 pobj prostaglandin,of
R2211 T4260 T4261 compound T,cells
R2212 T4209 T4208 nummod E2,prostaglandin
R2213 T4210 T4208 cc and,prostaglandin
R2214 T4211 T4212 amod nitric,oxide
R2215 T4261 T4257 pobj cells,by
R2216 T4212 T4208 conj oxide,prostaglandin
R2217 T4213 T4194 prep by,stimulates
R2218 T4262 T4261 prep in,cells
R2219 T4214 T4213 pobj chondrocytes,by
R2220 T4215 T4194 punct ",",stimulates
R2221 T4216 T4194 cc and,stimulates
R2222 T4263 T4267 det the,]
R2223 T4217 T4194 conj has,stimulates
R2224 T4218 T4219 det the,ability
R2225 T4219 T4217 dobj ability,has
R2226 T4264 T4265 compound synovium,[
R2227 T4220 T4221 aux to,differentiate
R2228 T4221 T4219 acl differentiate,ability
R2229 T4222 T4221 cc and,differentiate
R2230 T4265 T4267 compound [,]
R2231 T4223 T4221 conj activate,differentiate
R2232 T4224 T4226 det the,cells
R2233 T4225 T4226 amod dendritic,cells
R2234 T4226 T4223 dobj cells,activate
R2235 T4227 T4229 compound [,]
R2236 T4228 T4229 compound 8-10,]
R2237 T4266 T4267 compound "11,12",]
R2238 T4229 T4226 appos ],cells
R2239 T4230 T4194 punct .,stimulates
R2240 T4231 T4237 nsubj Levels,were
R2241 T4267 T4262 pobj ],in
R2242 T4232 T4231 prep of,Levels
R2243 T4233 T4232 pobj IL-17,of
R2244 T4234 T4231 prep in,Levels
R2245 T4268 T4256 punct .,produced
R2246 T4235 T4236 amod synovial,fluids
R2247 T4236 T4234 pobj fluids,in
R2248 T4237 T4237 ROOT were,were
R2249 T4269 T4271 nsubj IL-15,secreted
R2250 T4238 T4239 advmod significantly,higher
R2251 T4270 T4269 punct ",",IL-15
R2252 T4271 T4271 ROOT secreted,secreted
R2253 T4272 T4271 prep from,secreted
R2254 T4336 T4348 mark Although,documented
R2255 T4273 T4274 amod activated,macrophages
R2256 T4337 T4338 det the,contribution
R2257 T4338 T4348 nsubjpass contribution,documented
R2258 T4274 T4272 pobj macrophages,from
R2259 T4339 T4338 prep of,contribution
R2260 T4340 T4339 pobj IL-17,of
R2261 T4341 T4338 prep in,contribution
R2262 T4275 T4278 punct ",",reported
R2263 T4342 T4343 amod joint,inflammation
R2264 T4343 T4341 pobj inflammation,in
R2265 T4276 T4278 aux has,reported
R2266 T4344 T4343 prep in,inflammation
R2267 T4345 T4344 pobj RA,in
R2268 T4346 T4348 aux has,documented
R2269 T4277 T4278 auxpass been,reported
R2270 T4347 T4348 auxpass been,documented
R2271 T4348 T4364 advcl documented,remains
R2272 T4349 T4348 prep in,documented
R2273 T4278 T4271 conj reported,secreted
R2274 T4350 T4351 amod earlier,studies
R2275 T4351 T4349 pobj studies,in
R2276 T4352 T4354 compound [,]
R2277 T4279 T4280 aux to,be
R2278 T4353 T4354 compound "12,15,16",]
R2279 T4354 T4364 nsubj ],remains
R2280 T4355 T4354 punct ",",]
R2281 T4356 T4360 det the,pathway
R2282 T4357 T4360 amod intracellular,pathway
R2283 T4358 T4360 nmod signal,pathway
R2284 T4280 T4278 xcomp be,reported
R2285 T4359 T4360 compound transduction,pathway
R2286 T4360 T4354 appos pathway,]
R2287 T4281 T4283 det an,trigger
R2288 T4361 T4360 prep for,pathway
R2289 T4282 T4283 amod important,trigger
R2290 T4362 T4363 amod IL-17,production
R2291 T4363 T4361 pobj production,for
R2292 T4283 T4280 attr trigger,be
R2293 T4364 T4364 ROOT remains,remains
R2294 T4365 T4364 acomp uncertain,remains
R2295 T4366 T4364 punct .,remains
R2296 T4284 T4283 prep of,trigger
R2297 T4367 T4367 ROOT In,In
R2298 T4368 T4370 det the,study
R2299 T4369 T4370 amod present,study
R2300 T4285 T4286 amod IL-17,production
R2301 T4370 T4367 pobj study,In
R2302 T4286 T4284 pobj production,of
R2303 T4371 T4372 nsubj we,used
R2304 T4372 T4370 relcl used,study
R2305 T4373 T4374 amod various,stimuli
R2306 T4287 T4286 prep in,production
R2307 T4374 T4372 dobj stimuli,used
R2308 T4375 T4376 aux to,investigate
R2309 T4376 T4372 xcomp investigate,used
R2310 T4377 T4378 amod IL-17,production
R2311 T4288 T4292 compound RA,cells
R2312 T4378 T4376 dobj production,investigate
R2313 T4379 T4378 prep in,production
R2314 T4289 T4290 compound peripheral,blood
R2315 T4380 T4379 pobj PBMC,in
R2316 T4381 T4380 prep of,PBMC
R2317 T4382 T4381 pobj patients,of
R2318 T4290 T4291 compound blood,mononuclear
R2319 T4383 T4382 prep with,patients
R2320 T4384 T4383 pobj RA,with
R2321 T4385 T4384 cc and,RA
R2322 T4291 T4292 compound mononuclear,cells
R2323 T4386 T4389 poss its,pathway
R2324 T4387 T4389 amod signaling,pathway
R2325 T4292 T4287 pobj cells,in
R2326 T4388 T4389 compound transduction,pathway
R2327 T4389 T4384 conj pathway,RA
R2328 T4390 T4367 punct .,In
R2329 T4293 T4286 punct (,production
R2330 T4391 T4392 nsubj We,found
R2331 T4392 T4392 ROOT found,found
R2332 T4393 T4404 mark that,/
R2333 T4394 T4397 det the,pathway
R2334 T4395 T4397 amod intracellular,pathway
R2335 T4396 T4397 amod signaling,pathway
R2336 T4294 T4283 appos PBMC,trigger
R2337 T4397 T4404 nsubj pathway,/
R2338 T4398 T4397 acl involving,pathway
R2339 T4399 T4398 dobj phosphoinositide,involving
R2340 T4400 T4403 nmod 3-kinase,)
R2341 T4295 T4283 punct ),trigger
R2342 T4401 T4402 punct (,PI3K
R2343 T4402 T4400 appos PI3K,3-kinase
R2344 T4403 T4397 punct ),pathway
R2345 T4296 T4278 agent by,reported
R2346 T4404 T4392 ccomp /,found
R2347 T4405 T4404 dobj Akt,/
R2348 T4297 T4296 pobj cyclosporine,by
R2349 T4406 T4405 cc and,Akt
R2350 T4407 T4405 conj NF-κB,Akt
R2351 T4298 T4297 cc and,cyclosporine
R2352 T4408 T4410 aux might,involved
R2353 T4409 T4410 auxpass be,involved
R2354 T4410 T4392 conj involved,found
R2355 T4411 T4410 prep in,involved
R2356 T4299 T4301 amod steroid,pathways
R2357 T4412 T4413 det the,overproduction
R2358 T4413 T4411 pobj overproduction,in
R2359 T4414 T4413 prep of,overproduction
R2360 T4300 T4301 amod sensitive,pathways
R2361 T4415 T4419 det the,IL-17
R2362 T4416 T4419 amod key,IL-17
R2363 T4301 T4297 conj pathways,cyclosporine
R2364 T4417 T4418 amod inflammatory,cytokine
R2365 T4418 T4419 compound cytokine,IL-17
R2366 T4419 T4414 pobj IL-17,of
R2367 T4420 T4419 prep in,IL-17
R2368 T4302 T4304 nmod [,]
R2369 T4421 T4420 pobj RA,in
R2370 T4422 T4392 punct .,found
R2371 T4303 T4304 nummod 13,]
R2372 T4423 T4424 det These,results
R2373 T4424 T4426 nsubj results,provide
R2374 T4425 T4426 aux might,provide
R2375 T4304 T4278 conj ],reported
R2376 T4426 T4426 ROOT provide,provide
R2377 T4427 T4428 amod new,insights
R2378 T4428 T4426 dobj insights,provide
R2379 T4305 T4278 punct .,reported
R2380 T4429 T4426 prep into,provide
R2381 T4430 T4431 det the,pathogenesis
R2382 T4431 T4429 pobj pathogenesis,into
R2383 T4432 T4431 prep of,pathogenesis
R2384 T4306 T4312 advmod Recently,showed
R2385 T4307 T4312 punct ",",showed
R2386 T4433 T4432 pobj RA,of
R2387 T4434 T4431 cc and,pathogenesis
R2388 T4435 T4436 amod future,directions
R2389 T4308 T4312 nsubj Happel,showed
R2390 T4436 T4431 conj directions,pathogenesis
R2391 T4437 T4436 prep for,directions
R2392 T4438 T4440 amod new,strategies
R2393 T4309 T4308 cc and,Happel
R2394 T4439 T4440 amod therapeutic,strategies
R2395 T4440 T4437 pobj strategies,for
R2396 T4310 T4308 conj colleagues,Happel
R2397 T4441 T4440 prep in,strategies
R2398 T4311 T4312 advmod also,showed
R2399 T4442 T4441 pobj RA,in
R2400 T4443 T4426 punct .,provide
R2401 T4312 T4312 ROOT showed,showed
R2402 T4313 T4316 mark that,be
R2403 T4314 T4316 nsubj IL-23,be
R2404 T4315 T4316 aux could,be
R2405 T4316 T4312 ccomp be,showed
R2406 T4317 T4319 det an,trigger
R2407 T4318 T4319 amod efficient,trigger
R2408 T4319 T4316 attr trigger,be
R2409 T4320 T4319 prep of,trigger
R2410 T4321 T4322 amod IL-17,production
R2412 T4322 T4320 pobj production,of
R2414 T4323 T4319 prep from,trigger
R2416 T4324 T4326 preconj both,+
R2419 T4325 T4326 nummod CD4,+
R2422 T4326 T4323 pobj +,from
R2423 T4327 T4326 cc and,+
R2424 T4328 T4331 nummod CD8,cells
R2426 T4329 T4331 nummod +,cells
R2428 T4330 T4331 compound T,cells
R2430 T4331 T4326 conj cells,+
R2436 T4332 T4334 nmod [,]
R2437 T4333 T4334 nummod 14,]
R2440 T4334 T4331 appos ],cells
R2443 T4335 T4312 punct .,showed

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T3652 3051-3065 Gene_expression denotes overproduction
T3651 3090-3104 Protein denotes cytokine IL-17
T3650 3020-3025 Protein denotes NF-κB
T3649 3012-3015 Protein denotes Akt
T3648 3006-3010 Protein denotes PI3K
T3647 2979-3004 Protein denotes phosphoinositide 3-kinase
T3646 2840-2850 Gene_expression denotes production
T3645 2834-2839 Protein denotes IL-17
T3644 2603-2608 Protein denotes IL-17
T3643 2555-2559 Protein denotes CD8+
T3642 2546-2550 Protein denotes CD4+
T3641 2228-2236 Localization denotes secreted
T3640 2221-2226 Protein denotes IL-15
T3639 2090-2096 Positive_regulation denotes higher
T3638 2036-2042 Gene_expression denotes Levels
T3637 2183-2187 Protein denotes CD4+
T3636 2046-2051 Protein denotes IL-17
T3635 1818-1828 Positive_regulation denotes stimulates
T3634 1833-1843 Gene_expression denotes production
T3633 1847-1851 Protein denotes IL-6
T3632 1730-1747 Protein denotes nuclear factor κB
T3631 1628-1633 Protein denotes IL-17
T3630 1513-1518 Protein denotes IL-17
T3629 1507-1511 Protein denotes IL-1
T3628 1497-1502 Protein denotes TNF-α
T3627 1384-1390 Positive_regulation denotes induce
T3626 1384-1390 Positive_regulation denotes induce
T3625 1336-1344 Localization denotes secreted
T3624 1336-1344 Localization denotes secreted
T3623 1336-1344 Localization denotes secreted
T3622 1400-1404 Protein denotes IL-8
T3621 1391-1395 Protein denotes IL-6
T3620 1293-1298 Protein denotes IL-17
T3619 1148-1164 Protein denotes type II collagen
T3618 929-937 Gene_expression denotes abundant
T3617 929-937 Gene_expression denotes abundant
T3616 929-937 Gene_expression denotes abundant
T3615 929-937 Gene_expression denotes abundant
T3614 929-937 Gene_expression denotes abundant
T3613 929-937 Gene_expression denotes abundant
T3612 941-960 Protein denotes rheumatoid synovium
T3611 918-923 Protein denotes TNF-α
T3610 908-913 Protein denotes IL-18
T3609 901-906 Protein denotes IL-15
T3608 895-899 Protein denotes IL-6
T3607 889-893 Protein denotes IL-1
T3606 801-813 Protein denotes interferon-γ
T3605 792-796 Protein denotes IL-2
T3604 306-316 Negative_regulation denotes inhibitors
T3603 306-316 Negative_regulation denotes inhibitors
T3602 355-373 Protein denotes interleukin (IL)-1
T3601 320-349 Protein denotes tumor necrosis factor (TNF)-α
R1751 T3601 T3603 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1753 T3602 T3604 themeOf interleukin (IL)-1,inhibitors
R1754 T3607 T3613 themeOf IL-1,abundant
R1757 T3608 T3614 themeOf IL-6,abundant
R1758 T3609 T3615 themeOf IL-15,abundant
R1759 T3610 T3616 themeOf IL-18,abundant
R1760 T3611 T3617 themeOf TNF-α,abundant
R1761 T3612 T3618 themeOf rheumatoid synovium,abundant
R1762 T3620 T3623 themeOf IL-17,secreted
R1763 T3620 T3626 causeOf IL-17,induce
R1764 T3620 T3627 causeOf IL-17,induce
R1765 T3621 T3624 themeOf IL-6,secreted
R1766 T3621 T3626 themeOf IL-6,induce
R1767 T3622 T3625 themeOf IL-8,secreted
R1768 T3622 T3627 themeOf IL-8,induce
R1769 T3633 T3634 themeOf IL-6,production
R1770 T3634 T3635 themeOf production,stimulates
R1771 T3636 T3638 themeOf IL-17,Levels
R1772 T3638 T3639 themeOf Levels,higher
R1773 T3640 T3641 themeOf IL-15,secreted
R1774 T3645 T3646 themeOf IL-17,production
R1775 T3651 T3652 themeOf cytokine IL-17,overproduction

testone

Id Subject Object Predicate Lexical cue
T2153 3051-3065 Gene_expression denotes overproduction
T2152 3035-3043 Regulation denotes involved
T2151 2840-2850 Gene_expression denotes production
T2150 2744-2754 Gene_expression denotes production
T2149 2525-2535 Gene_expression denotes production
T2148 2508-2515 Positive_regulation denotes trigger
T2147 2319-2329 Gene_expression denotes production
T2146 2302-2309 Positive_regulation denotes trigger
T2145 2171-2179 Gene_expression denotes produced
T2144 1833-1843 Gene_expression denotes production
T2143 1818-1828 Positive_regulation denotes stimulates
T2142 1688-1697 Positive_regulation denotes induction
T2141 1565-1573 Gene_expression denotes produced
T2140 1384-1390 Positive_regulation denotes induce
T2139 3099-3104 Protein denotes IL-17
T2138 3012-3015 Protein denotes Akt
T2137 2834-2839 Protein denotes IL-17
T2136 2738-2743 Protein denotes IL-17
T2135 2603-2608 Protein denotes IL-17
T2134 2555-2558 Protein denotes CD8
T2133 2546-2549 Protein denotes CD4
T2132 2519-2524 Protein denotes IL-17
T2131 2480-2485 Protein denotes IL-23
T2130 2313-2318 Protein denotes IL-17
T2129 2221-2226 Protein denotes IL-15
T2128 2183-2186 Protein denotes CD4
T2127 2046-2051 Protein denotes IL-17
T2126 1856-1882 Protein denotes leukemia inhibitory factor
T2125 1847-1851 Protein denotes IL-6
T2124 1708-1762 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2123 1701-1706 Protein denotes RANKL
T2122 1628-1633 Protein denotes IL-17
T2121 1513-1518 Protein denotes IL-17
T2120 1507-1511 Protein denotes IL-1
T2119 1497-1502 Protein denotes TNF-α
T2118 1400-1404 Protein denotes IL-8
T2117 1391-1395 Protein denotes IL-6
T2116 1293-1298 Protein denotes IL-17
T2115 918-923 Protein denotes TNF-α
T2114 908-913 Protein denotes IL-18
T2113 901-906 Protein denotes IL-15
T2112 895-899 Protein denotes IL-6
T2111 889-893 Protein denotes IL-1
T2110 801-813 Protein denotes interferon-γ
T2109 792-796 Protein denotes IL-2
T2108 355-373 Protein denotes interleukin (IL)-1
T2107 320-349 Protein denotes tumor necrosis factor (TNF)-α
R1068 T2116 T2140 causeOf IL-17,induce
R1069 T2117 T2140 themeOf IL-6,induce
R1070 T2118 T2140 themeOf IL-8,induce
R1071 T2119 T2141 themeOf TNF-α,produced
R1072 T2120 T2141 themeOf IL-1,produced
R1073 T2121 T2141 themeOf IL-17,produced
R1074 T2123 T2142 themeOf RANKL,induction
R1075 T2124 T2142 themeOf receptor activator of nuclear factor κB [NF-κB] ligand,induction
R1076 T2124 T2123 equivalentTo receptor activator of nuclear factor κB [NF-κB] ligand,RANKL
R1077 T2125 T2144 themeOf IL-6,production
R1078 T2126 T2144 themeOf leukemia inhibitory factor,production
R1079 T2127 T2145 themeOf IL-17,produced
R1080 T2130 T2147 themeOf IL-17,production
R1081 T2131 T2148 causeOf IL-23,trigger
R1082 T2132 T2149 themeOf IL-17,production
R1083 T2136 T2150 themeOf IL-17,production
R1084 T2137 T2151 themeOf IL-17,production
R1085 T2139 T2153 themeOf IL-17,overproduction
R1086 T2144 T2143 themeOf production,stimulates
R1087 T2147 T2146 themeOf production,trigger
R1088 T2149 T2148 themeOf production,trigger
R1089 T2153 T2152 themeOf overproduction,involved