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of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. 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of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T12843","span":{"begin":903,"end":909},"obj":"Protein"},{"id":"T12842","span":{"begin":882,"end":888},"obj":"Protein"},{"id":"T12841","span":{"begin":865,"end":869},"obj":"Protein"},{"id":"T12840","span":{"begin":737,"end":742},"obj":"Protein"},{"id":"T12839","span":{"begin":691,"end":695},"obj":"Protein"},{"id":"T12838","span":{"begin":671,"end":676},"obj":"Protein"},{"id":"T12837","span":{"begin":621,"end":626},"obj":"Protein"},{"id":"T12836","span":{"begin":590,"end":595},"obj":"Protein"},{"id":"T12835","span":{"begin":570,"end":575},"obj":"Protein"},{"id":"T12834","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T12833","span":{"begin":534,"end":539},"obj":"Protein"},{"id":"T12832","span":{"begin":503,"end":508},"obj":"Protein"},{"id":"T12831","span":{"begin":468,"end":473},"obj":"Protein"},{"id":"T12830","span":{"begin":423,"end":428},"obj":"Protein"},{"id":"T12829","span":{"begin":264,"end":269},"obj":"Protein"},{"id":"T12828","span":{"begin":14,"end":19},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T12924","span":{"begin":882,"end":888},"obj":"http://www.uniprot.org/uniprot/P10147"},{"id":"T12923","span":{"begin":865,"end":869},"obj":"http://www.uniprot.org/uniprot/P10145"},{"id":"T12922","span":{"begin":691,"end":695},"obj":"http://www.uniprot.org/uniprot/P05231"},{"id":"T12921","span":{"begin":590,"end":595},"obj":"http://www.uniprot.org/uniprot/P01137"},{"id":"T12920","span":{"begin":552,"end":557},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T12919","span":{"begin":534,"end":539},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T12918","span":{"begin":503,"end":508},"obj":"http://www.uniprot.org/uniprot/P40933"},{"id":"T12917","span":{"begin":737,"end":742},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12916","span":{"begin":621,"end":626},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12915","span":{"begin":468,"end":473},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12914","span":{"begin":423,"end":428},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12913","span":{"begin":264,"end":269},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12912","span":{"begin":14,"end":19},"obj":"http://www.uniprot.org/uniprot/Q16552"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"GO-BP","denotations":[{"id":"T12607","span":{"begin":671,"end":674},"obj":"http://purl.obolibrary.org/obo/GO_0004298"},{"id":"T12606","span":{"begin":423,"end":439},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T12605","span":{"begin":14,"end":30},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T12604","span":{"begin":423,"end":439},"obj":"http://purl.obolibrary.org/obo/GO_0032660"},{"id":"T12603","span":{"begin":14,"end":30},"obj":"http://purl.obolibrary.org/obo/GO_0032660"},{"id":"T12602","span":{"begin":0,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"GO-MF","denotations":[{"id":"T12854","span":{"begin":865,"end":869},"obj":"http://purl.obolibrary.org/obo/GO_0005153"},{"id":"T12853","span":{"begin":691,"end":695},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T12852","span":{"begin":671,"end":674},"obj":"http://purl.obolibrary.org/obo/GO_0004298"},{"id":"T12851","span":{"begin":570,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0045515"},{"id":"T12850","span":{"begin":503,"end":508},"obj":"http://purl.obolibrary.org/obo/GO_0016170"},{"id":"T12849","span":{"begin":737,"end":742},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T12848","span":{"begin":621,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T12847","span":{"begin":468,"end":473},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T12846","span":{"begin":423,"end":428},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T12845","span":{"begin":264,"end":269},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T12844","span":{"begin":14,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0030367"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"GO-CC","denotations":[{"id":"T12857","span":{"begin":277,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12856","span":{"begin":143,"end":148},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12855","span":{"begin":115,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"sentences","denotations":[{"id":"T12601","span":{"begin":653,"end":931},"obj":"Sentence"},{"id":"T12600","span":{"begin":441,"end":652},"obj":"Sentence"},{"id":"T12599","span":{"begin":284,"end":440},"obj":"Sentence"},{"id":"T12598","span":{"begin":83,"end":283},"obj":"Sentence"},{"id":"T12597","span":{"begin":0,"end":82},"obj":"Sentence"},{"id":"T124","span":{"begin":0,"end":82},"obj":"Sentence"},{"id":"T125","span":{"begin":83,"end":283},"obj":"Sentence"},{"id":"T126","span":{"begin":284,"end":440},"obj":"Sentence"},{"id":"T127","span":{"begin":441,"end":652},"obj":"Sentence"},{"id":"T128","span":{"begin":653,"end":931},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

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of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T12895","span":{"begin":720,"end":733},"obj":"Positive_regulation"},{"id":"T12894","span":{"begin":903,"end":909},"obj":"Protein"},{"id":"T12893","span":{"begin":882,"end":888},"obj":"Protein"},{"id":"T12892","span":{"begin":865,"end":869},"obj":"Protein"},{"id":"T12891","span":{"begin":737,"end":751},"obj":"Protein"},{"id":"T12890","span":{"begin":691,"end":695},"obj":"Protein"},{"id":"T12889","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12888","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12887","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12886","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12885","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12884","span":{"begin":632,"end":641},"obj":"Positive_regulation"},{"id":"T12883","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T12882","span":{"begin":590,"end":595},"obj":"Protein"},{"id":"T12881","span":{"begin":570,"end":575},"obj":"Protein"},{"id":"T12880","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T12879","span":{"begin":534,"end":539},"obj":"Protein"},{"id":"T12878","span":{"begin":503,"end":508},"obj":"Protein"},{"id":"T12877","span":{"begin":91,"end":98},"obj":"Protein"},{"id":"T12876","span":{"begin":0,"end":10},"obj":"Regulation"},{"id":"T12875","span":{"begin":20,"end":30},"obj":"Gene_expression"},{"id":"T12874","span":{"begin":14,"end":19},"obj":"Protein"}],"relations":[{"id":"R6980","pred":"themeOf","subj":"T12874","obj":"T12875"},{"id":"R6981","pred":"themeOf","subj":"T12875","obj":"T12876"},{"id":"R6982","pred":"themeOf","subj":"T12879","obj":"T12884"},{"id":"R6983","pred":"themeOf","subj":"T12879","obj":"T12886"},{"id":"R6984","pred":"themeOf","subj":"T12879","obj":"T12888"},{"id":"R6985","pred":"causeOf","subj":"T12880","obj":"T12884"},{"id":"R6986","pred":"causeOf","subj":"T12880","obj":"T12885"},{"id":"R6987","pred":"causeOf","subj":"T12881","obj":"T12886"},{"id":"R6988","pred":"causeOf","subj":"T12881","obj":"T12887"},{"id":"R6989","pred":"causeOf","subj":"T12882","obj":"T12888"},{"id":"R6990","pred":"causeOf","subj":"T12882","obj":"T12889"},{"id":"R6991","pred":"themeOf","subj":"T12883","obj":"T12885"},{"id":"R6992","pred":"themeOf","subj":"T12883","obj":"T12887"},{"id":"R6993","pred":"themeOf","subj":"T12883","obj":"T12889"},{"id":"R6994","pred":"themeOf","subj":"T12891","obj":"T12895"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}

{"project":"testone","denotations":[{"id":"T12407","span":{"begin":456,"end":464},"obj":"Positive_regulation"},{"id":"T12406","span":{"begin":429,"end":439},"obj":"Gene_expression"},{"id":"T12405","span":{"begin":250,"end":260},"obj":"Gene_expression"},{"id":"T12404","span":{"begin":237,"end":245},"obj":"Regulation"},{"id":"T12403","span":{"begin":20,"end":30},"obj":"Gene_expression"},{"id":"T12402","span":{"begin":0,"end":10},"obj":"Regulation"},{"id":"T12401","span":{"begin":903,"end":909},"obj":"Protein"},{"id":"T12400","span":{"begin":882,"end":888},"obj":"Protein"},{"id":"T12399","span":{"begin":865,"end":869},"obj":"Protein"},{"id":"T12398","span":{"begin":737,"end":742},"obj":"Protein"},{"id":"T12397","span":{"begin":691,"end":695},"obj":"Protein"},{"id":"T12396","span":{"begin":671,"end":676},"obj":"Protein"},{"id":"T12395","span":{"begin":621,"end":626},"obj":"Protein"},{"id":"T12394","span":{"begin":590,"end":595},"obj":"Protein"},{"id":"T12393","span":{"begin":570,"end":575},"obj":"Protein"},{"id":"T12392","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T12391","span":{"begin":534,"end":539},"obj":"Protein"},{"id":"T12390","span":{"begin":503,"end":508},"obj":"Protein"},{"id":"T12389","span":{"begin":468,"end":473},"obj":"Protein"},{"id":"T12388","span":{"begin":423,"end":428},"obj":"Protein"},{"id":"T12387","span":{"begin":264,"end":269},"obj":"Protein"},{"id":"T12386","span":{"begin":14,"end":19},"obj":"Protein"}],"relations":[{"id":"R6738","pred":"themeOf","subj":"T12386","obj":"T12403"},{"id":"R6739","pred":"themeOf","subj":"T12387","obj":"T12405"},{"id":"R6740","pred":"themeOf","subj":"T12388","obj":"T12406"},{"id":"R6741","pred":"themeOf","subj":"T12389","obj":"T12407"},{"id":"R6742","pred":"causeOf","subj":"T12390","obj":"T12407"},{"id":"R6743","pred":"causeOf","subj":"T12391","obj":"T12407"},{"id":"R6744","pred":"causeOf","subj":"T12392","obj":"T12407"},{"id":"R6745","pred":"causeOf","subj":"T12393","obj":"T12407"},{"id":"R6746","pred":"causeOf","subj":"T12394","obj":"T12407"},{"id":"R6747","pred":"causeOf","subj":"T12395","obj":"T12407"},{"id":"R6748","pred":"themeOf","subj":"T12403","obj":"T12402"},{"id":"R6749","pred":"themeOf","subj":"T12405","obj":"T12404"}],"text":"Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines\nBecause RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells. To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production. We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a). When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P \u003c 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b)."}