PMC:1064895 / 16120-16968 JSONTXT

{"project":"test3","denotations":[{"id":"T11677","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T11676","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T11675","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T11674","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T11673","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T11672","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T11671","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T11670","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T11669","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T11668","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T11667","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T11666","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T11665","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T11664","span":{"begin":321,"end":330},"obj":"Regulation"},{"id":"T11663","span":{"begin":152,"end":160},"obj":"Gene_expression"},{"id":"T11662","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T11661","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T11660","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T11659","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T11658","span":{"begin":10,"end":15},"obj":"Protein"},{"id":"T11657","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T11656","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T11655","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T11654","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T11653","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T11652","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T11651","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T11650","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T11649","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T11648","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T11647","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T11646","span":{"begin":10,"end":15},"obj":"Protein"}],"relations":[{"id":"R6317","pred":"themeOf","subj":"T11658","obj":"T11659"},{"id":"R6318","pred":"themeOf","subj":"T11659","obj":"T11657"},{"id":"R6319","pred":"causeOf","subj":"T11661","obj":"T11657"},{"id":"R6320","pred":"themeOf","subj":"T11662","obj":"T11663"},{"id":"R6321","pred":"themeOf","subj":"T11666","obj":"T11665"},{"id":"R6322","pred":"themeOf","subj":"T11668","obj":"T11669"},{"id":"R6323","pred":"themeOf","subj":"T11669","obj":"T11667"},{"id":"R6324","pred":"themeOf","subj":"T11672","obj":"T11671"},{"id":"R6325","pred":"themeOf","subj":"T11675","obj":"T11676"},{"id":"R6326","pred":"themeOf","subj":"T11676","obj":"T11674"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T12075","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T12074","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T12073","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T12072","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T12071","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T12070","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T12069","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T12068","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T12067","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T12066","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T12065","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12064","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T12063","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T12062","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T12061","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T12060","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T12059","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T12058","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T12057","span":{"begin":10,"end":15},"obj":"Protein"}],"relations":[{"id":"R6511","pred":"themeOf","subj":"T12057","obj":"T12069"},{"id":"R6512","pred":"themeOf","subj":"T12061","obj":"T12070"},{"id":"R6513","pred":"themeOf","subj":"T12062","obj":"T12071"},{"id":"R6514","pred":"themeOf","subj":"T12064","obj":"T12072"},{"id":"R6515","pred":"themeOf","subj":"T12065","obj":"T12075"},{"id":"R6516","pred":"themeOf","subj":"T12069","obj":"T12068"},{"id":"R6517","pred":"themeOf","subj":"T12071","obj":"T12073"},{"id":"R6518","pred":"themeOf","subj":"T12075","obj":"T12074"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T12358","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T12357","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T12356","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T12355","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T12354","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T12353","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T12352","span":{"begin":152,"end":160},"obj":"Gene_expression"},{"id":"T12351","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T12350","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T12349","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T12348","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T12347","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12346","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T12345","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T12344","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T12343","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T12342","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T12341","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T12340","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T12339","span":{"begin":10,"end":15},"obj":"Protein"}],"relations":[{"id":"R6729","pred":"themeOf","subj":"T12339","obj":"T12350"},{"id":"R6730","pred":"themeOf","subj":"T12342","obj":"T12352"},{"id":"R6731","pred":"themeOf","subj":"T12343","obj":"T12353"},{"id":"R6732","pred":"themeOf","subj":"T12344","obj":"T12354"},{"id":"R6733","pred":"themeOf","subj":"T12346","obj":"T12356"},{"id":"R6734","pred":"themeOf","subj":"T12347","obj":"T12357"},{"id":"R6735","pred":"themeOf","subj":"T12350","obj":"T12351"},{"id":"R6736","pred":"themeOf","subj":"T12354","obj":"T12355"},{"id":"R6737","pred":"themeOf","subj":"T12357","obj":"T12358"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"biosemtest","denotations":[{"id":"T11760","span":{"begin":617,"end":630},"obj":"UMLS/C0332232"},{"id":"T11759","span":{"begin":38,"end":46},"obj":"UMLS/C1578479"},{"id":"T11758","span":{"begin":391,"end":395},"obj":"UMLS/C0323983"},{"id":"T11757","span":{"begin":358,"end":362},"obj":"UMLS/C1511726"},{"id":"T11756","span":{"begin":610,"end":615},"obj":"UMLS/C1825592"},{"id":"T11755","span":{"begin":344,"end":349},"obj":"UMLS/C1825592"},{"id":"T11754","span":{"begin":101,"end":106},"obj":"UMLS/C1825592"},{"id":"T11753","span":{"begin":38,"end":46},"obj":"UMLS/C1578483"},{"id":"T11752","span":{"begin":738,"end":754},"obj":"UMLS/C1819444"},{"id":"T11751","span":{"begin":517,"end":533},"obj":"UMLS/C1819444"},{"id":"T11750","span":{"begin":10,"end":26},"obj":"UMLS/C1819444"},{"id":"T11749","span":{"begin":38,"end":46},"obj":"UMLS/C1578480"},{"id":"T11748","span":{"begin":38,"end":46},"obj":"UMLS/C1578481"},{"id":"T11747","span":{"begin":38,"end":46},"obj":"UMLS/C1578486"},{"id":"T11746","span":{"begin":38,"end":46},"obj":"UMLS/C1578484"},{"id":"T11745","span":{"begin":38,"end":46},"obj":"UMLS/C1578485"},{"id":"T11744","span":{"begin":723,"end":726},"obj":"UMLS/C0030779"},{"id":"T11743","span":{"begin":89,"end":92},"obj":"UMLS/C0030779"},{"id":"T11742","span":{"begin":350,"end":356},"obj":"UMLS/C0441889"},{"id":"T11741","span":{"begin":130,"end":137},"obj":"UMLS/C1279919"},{"id":"T11740","span":{"begin":119,"end":124},"obj":"UMLS/C0205309"},{"id":"T11739","span":{"begin":283,"end":300},"obj":"UMLS/C1155065"},{"id":"T11738","span":{"begin":193,"end":205},"obj":"UMLS/C1292732"},{"id":"T11737","span":{"begin":210,"end":216},"obj":"UMLS/C2348382"},{"id":"T11736","span":{"begin":38,"end":46},"obj":"UMLS/C1550655"},{"id":"T11735","span":{"begin":684,"end":693},"obj":"UMLS/C1439852"},{"id":"T11734","span":{"begin":759,"end":763},"obj":"UMLS/C0205172"},{"id":"T11733","span":{"begin":605,"end":609},"obj":"UMLS/C0205172"},{"id":"T11732","span":{"begin":610,"end":615},"obj":"UMLS/C1623218"},{"id":"T11731","span":{"begin":344,"end":349},"obj":"UMLS/C1623218"},{"id":"T11730","span":{"begin":101,"end":106},"obj":"UMLS/C1623218"},{"id":"T11729","span":{"begin":317,"end":331},"obj":"UMLS/C1512045"},{"id":"T11728","span":{"begin":706,"end":714},"obj":"UMLS/C0026249"},{"id":"T11727","span":{"begin":171,"end":180},"obj":"UMLS/C1879547"},{"id":"T11726","span":{"begin":363,"end":366},"obj":"UMLS/C1518422"},{"id":"T11725","span":{"begin":723,"end":726},"obj":"UMLS/C0031858"},{"id":"T11724","span":{"begin":89,"end":92},"obj":"UMLS/C0031858"},{"id":"T11723","span":{"begin":400,"end":405},"obj":"UMLS/C1707391"},{"id":"T11722","span":{"begin":38,"end":46},"obj":"UMLS/C1705908"},{"id":"T11721","span":{"begin":659,"end":664},"obj":"UMLS/C0439044"},{"id":"T11720","span":{"begin":210,"end":216},"obj":"UMLS/C1280500"},{"id":"T11719","span":{"begin":558,"end":569},"obj":"UMLS/C1947911"},{"id":"T11718","span":{"begin":759,"end":763},"obj":"UMLS/C0439064"},{"id":"T11717","span":{"begin":605,"end":609},"obj":"UMLS/C0439064"},{"id":"T11716","span":{"begin":706,"end":714},"obj":"UMLS/C0018284"},{"id":"T11715","span":{"begin":146,"end":148},"obj":"UMLS/C0319022"},{"id":"T11714","span":{"begin":138,"end":145},"obj":"UMLS/C1709908"},{"id":"T11713","span":{"begin":433,"end":446},"obj":"UMLS/C0086045"},{"id":"T11712","span":{"begin":230,"end":244},"obj":"UMLS/C0086045"},{"id":"T11711","span":{"begin":421,"end":432},"obj":"UMLS/C1948023"},{"id":"T11710","span":{"begin":835,"end":840},"obj":"UMLS/C0439297"},{"id":"T11709","span":{"begin":728,"end":737},"obj":"UMLS/C0442805"},{"id":"T11708","span":{"begin":332,"end":340},"obj":"UMLS/C0442805"},{"id":"T11707","span":{"begin":0,"end":9},"obj":"UMLS/C0442805"},{"id":"T11706","span":{"begin":534,"end":539},"obj":"UMLS/C0547043"},{"id":"T11705","span":{"begin":699,"end":705},"obj":"UMLS/C0039194"},{"id":"T11704","span":{"begin":181,"end":188},"obj":"UMLS/C0039194"},{"id":"T11703","span":{"begin":728,"end":737},"obj":"UMLS/C0442808"},{"id":"T11702","span":{"begin":332,"end":340},"obj":"UMLS/C0442808"},{"id":"T11701","span":{"begin":0,"end":9},"obj":"UMLS/C0442808"},{"id":"T11700","span":{"begin":138,"end":145},"obj":"UMLS/C0700287"},{"id":"T11699","span":{"begin":382,"end":387},"obj":"UMLS/C1527178"},{"id":"T11698","span":{"begin":473,"end":478},"obj":"UMLS/C0039224"},{"id":"T11697","span":{"begin":610,"end":615},"obj":"UMLS/C1522571"},{"id":"T11696","span":{"begin":344,"end":349},"obj":"UMLS/C1522571"},{"id":"T11695","span":{"begin":101,"end":106},"obj":"UMLS/C1522571"},{"id":"T11694","span":{"begin":38,"end":46},"obj":"UMLS/C0030705"},{"id":"T11693","span":{"begin":728,"end":737},"obj":"UMLS/C0205217"},{"id":"T11692","span":{"begin":332,"end":340},"obj":"UMLS/C0205217"},{"id":"T11691","span":{"begin":0,"end":9},"obj":"UMLS/C0205217"},{"id":"T11690","span":{"begin":421,"end":432},"obj":"UMLS/C1292856"},{"id":"T11689","span":{"begin":350,"end":356},"obj":"UMLS/C0456079"},{"id":"T11688","span":{"begin":558,"end":569},"obj":"UMLS/C0453882"},{"id":"T11687","span":{"begin":558,"end":569},"obj":"UMLS/C0205195"},{"id":"T11686","span":{"begin":220,"end":229},"obj":"UMLS/C1705242"},{"id":"T11685","span":{"begin":30,"end":34},"obj":"UMLS/C1321301"},{"id":"T11684","span":{"begin":433,"end":446},"obj":"UMLS/C1446561"},{"id":"T11683","span":{"begin":230,"end":244},"obj":"UMLS/C1446561"},{"id":"T11682","span":{"begin":473,"end":478},"obj":"UMLS/C1706073"},{"id":"T11681","span":{"begin":473,"end":478},"obj":"UMLS/C1706074"},{"id":"T11680","span":{"begin":610,"end":615},"obj":"UMLS/C0384648"},{"id":"T11679","span":{"begin":344,"end":349},"obj":"UMLS/C0384648"},{"id":"T11678","span":{"begin":101,"end":106},"obj":"UMLS/C0384648"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"pmc-enju-pas","denotations":[{"id":"T11847","span":{"begin":282,"end":283},"obj":"NN"},{"id":"T11846","span":{"begin":280,"end":281},"obj":"DT"},{"id":"T11845","span":{"begin":277,"end":279},"obj":"IN"},{"id":"T11844","span":{"begin":275,"end":276},"obj":"-RRB-"},{"id":"T11843","span":{"begin":270,"end":275},"obj":"NN"},{"id":"T11842","span":{"begin":267,"end":269},"obj":"CD"},{"id":"T11841","span":{"begin":263,"end":266},"obj":"CC"},{"id":"T11840","span":{"begin":261,"end":262},"obj":"CD"},{"id":"T11839","span":{"begin":259,"end":260},"obj":"-COMMA-"},{"id":"T11838","span":{"begin":258,"end":259},"obj":"CD"},{"id":"T11837","span":{"begin":257,"end":258},"obj":"-LRB-"},{"id":"T11836","span":{"begin":248,"end":256},"obj":"NN"},{"id":"T11835","span":{"begin":245,"end":247},"obj":"IN"},{"id":"T11834","span":{"begin":230,"end":244},"obj":"NN"},{"id":"T11833","span":{"begin":220,"end":229},"obj":"JJ"},{"id":"T11832","span":{"begin":217,"end":219},"obj":"IN"},{"id":"T11831","span":{"begin":210,"end":216},"obj":"NN"},{"id":"T11830","span":{"begin":206,"end":209},"obj":"DT"},{"id":"T11829","span":{"begin":193,"end":205},"obj":"VB"},{"id":"T11828","span":{"begin":190,"end":192},"obj":"PRP"},{"id":"T11827","span":{"begin":188,"end":189},"obj":"-COMMA-"},{"id":"T11826","span":{"begin":183,"end":188},"obj":"NN"},{"id":"T11825","span":{"begin":181,"end":182},"obj":"NN"},{"id":"T11824","span":{"begin":171,"end":180},"obj":"VB"},{"id":"T11823","span":{"begin":168,"end":170},"obj":"IN"},{"id":"T11822","span":{"begin":161,"end":167},"obj":"RB"},{"id":"T11821","span":{"begin":152,"end":160},"obj":"VB"},{"id":"T11820","span":{"begin":149,"end":151},"obj":"VB"},{"id":"T11819","span":{"begin":146,"end":148},"obj":"TO"},{"id":"T11818","span":{"begin":138,"end":145},"obj":"NN"},{"id":"T11817","span":{"begin":130,"end":137},"obj":"JJ"},{"id":"T11816","span":{"begin":125,"end":129},"obj":"IN"},{"id":"T11815","span":{"begin":119,"end":124},"obj":"VB"},{"id":"T11814","span":{"begin":111,"end":118},"obj":"RB"},{"id":"T11813","span":{"begin":107,"end":110},"obj":"VB"},{"id":"T11812","span":{"begin":101,"end":106},"obj":"NN"},{"id":"T11811","span":{"begin":93,"end":100},"obj":"IN"},{"id":"T11810","span":{"begin":89,"end":92},"obj":"NN"},{"id":"T11809","span":{"begin":85,"end":88},"obj":"CC"},{"id":"T11808","span":{"begin":83,"end":84},"obj":"-COMMA-"},{"id":"T11807","span":{"begin":74,"end":83},"obj":"NN"},{"id":"T11806","span":{"begin":67,"end":73},"obj":"CC"},{"id":"T11805","span":{"begin":58,"end":66},"obj":"JJ"},{"id":"T11804","span":{"begin":55,"end":57},"obj":"IN"},{"id":"T11803","span":{"begin":52,"end":54},"obj":"NN"},{"id":"T11802","span":{"begin":47,"end":51},"obj":"IN"},{"id":"T11801","span":{"begin":38,"end":46},"obj":"NN"},{"id":"T11800","span":{"begin":35,"end":37},"obj":"IN"},{"id":"T11799","span":{"begin":30,"end":34},"obj":"NN"},{"id":"T11798","span":{"begin":27,"end":29},"obj":"IN"},{"id":"T11797","span":{"begin":16,"end":26},"obj":"NN"},{"id":"T11796","span":{"begin":10,"end":15},"obj":"NN"},{"id":"T11795","span":{"begin":0,"end":9},"obj":"VB"},{"id":"T11948","span":{"begin":846,"end":847},"obj":"-RRB-"},{"id":"T11947","span":{"begin":842,"end":846},"obj":"CD"},{"id":"T11946","span":{"begin":840,"end":841},"obj":"SYM"},{"id":"T11945","span":{"begin":838,"end":839},"obj":"NN"},{"id":"T11944","span":{"begin":836,"end":837},"obj":"-COLON-"},{"id":"T11943","span":{"begin":831,"end":836},"obj":"NN"},{"id":"T11942","span":{"begin":829,"end":830},"obj":"CD"},{"id":"T11941","span":{"begin":827,"end":828},"obj":"SYM"},{"id":"T11940","span":{"begin":823,"end":826},"obj":"CD"},{"id":"T11939","span":{"begin":816,"end":822},"obj":"IN"},{"id":"T11938","span":{"begin":813,"end":815},"obj":"CD"},{"id":"T11937","span":{"begin":811,"end":812},"obj":"SYM"},{"id":"T11936","span":{"begin":807,"end":810},"obj":"CD"},{"id":"T11935","span":{"begin":806,"end":807},"obj":"-LRB-"},{"id":"T11934","span":{"begin":796,"end":805},"obj":"JJ"},{"id":"T11933","span":{"begin":792,"end":795},"obj":"CC"},{"id":"T11932","span":{"begin":783,"end":791},"obj":"JJ"},{"id":"T11931","span":{"begin":778,"end":782},"obj":"IN"},{"id":"T11930","span":{"begin":773,"end":777},"obj":"IN"},{"id":"T11929","span":{"begin":762,"end":772},"obj":"JJ"},{"id":"T11928","span":{"begin":757,"end":761},"obj":"RB"},{"id":"T11927","span":{"begin":753,"end":756},"obj":"VB"},{"id":"T11926","span":{"begin":742,"end":752},"obj":"NN"},{"id":"T11925","span":{"begin":736,"end":741},"obj":"NN"},{"id":"T11924","span":{"begin":726,"end":735},"obj":"VB"},{"id":"T11923","span":{"begin":724,"end":725},"obj":"-COMMA-"},{"id":"T11922","span":{"begin":721,"end":724},"obj":"NN"},{"id":"T11921","span":{"begin":718,"end":720},"obj":"IN"},{"id":"T11920","span":{"begin":713,"end":717},"obj":"JJ"},{"id":"T11919","span":{"begin":704,"end":712},"obj":"NN"},{"id":"T11918","span":{"begin":699,"end":703},"obj":"NN"},{"id":"T11917","span":{"begin":697,"end":698},"obj":"NN"},{"id":"T11916","span":{"begin":692,"end":696},"obj":"IN"},{"id":"T11915","span":{"begin":682,"end":691},"obj":"VB"},{"id":"T11914","span":{"begin":677,"end":681},"obj":"WRB"},{"id":"T11913","span":{"begin":675,"end":676},"obj":"-COMMA-"},{"id":"T11912","span":{"begin":664,"end":675},"obj":"RB"},{"id":"T11911","span":{"begin":657,"end":662},"obj":"RB"},{"id":"T11910","span":{"begin":648,"end":656},"obj":"NN"},{"id":"T11909","span":{"begin":643,"end":647},"obj":"IN"},{"id":"T11908","span":{"begin":641,"end":642},"obj":"-RRB-"},{"id":"T11907","span":{"begin":629,"end":641},"obj":"RB"},{"id":"T11906","span":{"begin":615,"end":628},"obj":"RB"},{"id":"T11905","span":{"begin":614,"end":615},"obj":"-LRB-"},{"id":"T11904","span":{"begin":608,"end":613},"obj":"NN"},{"id":"T11903","span":{"begin":603,"end":607},"obj":"JJ"},{"id":"T11902","span":{"begin":594,"end":602},"obj":"VB"},{"id":"T11901","span":{"begin":585,"end":593},"obj":"NN"},{"id":"T11900","span":{"begin":581,"end":584},"obj":"CC"},{"id":"T11899","span":{"begin":571,"end":580},"obj":"NN"},{"id":"T11898","span":{"begin":568,"end":570},"obj":"IN"},{"id":"T11897","span":{"begin":556,"end":567},"obj":"NN"},{"id":"T11896","span":{"begin":552,"end":555},"obj":"DT"},{"id":"T11895","span":{"begin":548,"end":551},"obj":"CC"},{"id":"T11894","span":{"begin":546,"end":547},"obj":"-COMMA-"},{"id":"T11893","span":{"begin":538,"end":546},"obj":"RB"},{"id":"T11892","span":{"begin":535,"end":537},"obj":"TO"},{"id":"T11891","span":{"begin":532,"end":534},"obj":"IN"},{"id":"T11890","span":{"begin":521,"end":531},"obj":"NN"},{"id":"T11889","span":{"begin":515,"end":520},"obj":"NN"},{"id":"T11888","span":{"begin":503,"end":514},"obj":"VB"},{"id":"T11887","span":{"begin":489,"end":502},"obj":"RB"},{"id":"T11886","span":{"begin":480,"end":488},"obj":"JJ"},{"id":"T11885","span":{"begin":478,"end":479},"obj":"-COMMA-"},{"id":"T11884","span":{"begin":477,"end":478},"obj":"CD"},{"id":"T11883","span":{"begin":471,"end":476},"obj":"JJ"},{"id":"T11882","span":{"begin":468,"end":470},"obj":"IN"},{"id":"T11881","span":{"begin":462,"end":467},"obj":"VB"},{"id":"T11880","span":{"begin":459,"end":461},"obj":"IN"},{"id":"T11879","span":{"begin":449,"end":457},"obj":"NN"},{"id":"T11878","span":{"begin":445,"end":448},"obj":"IN"},{"id":"T11877","span":{"begin":431,"end":444},"obj":"NN"},{"id":"T11876","span":{"begin":419,"end":430},"obj":"NN"},{"id":"T11875","span":{"begin":417,"end":418},"obj":"DT"},{"id":"T11874","span":{"begin":414,"end":416},"obj":"IN"},{"id":"T11873","span":{"begin":408,"end":413},"obj":"NN"},{"id":"T11872","span":{"begin":405,"end":407},"obj":"CD"},{"id":"T11871","span":{"begin":399,"end":404},"obj":"VB"},{"id":"T11870","span":{"begin":396,"end":398},"obj":"PRP"},{"id":"T11869","span":{"begin":394,"end":395},"obj":"-COMMA-"},{"id":"T11868","span":{"begin":390,"end":394},"obj":"DT"},{"id":"T11867","span":{"begin":387,"end":389},"obj":"IN"},{"id":"T11866","span":{"begin":381,"end":386},"obj":"NN"},{"id":"T11865","span":{"begin":377,"end":380},"obj":"DT"},{"id":"T11864","span":{"begin":374,"end":376},"obj":"IN"},{"id":"T11863","span":{"begin":371,"end":372},"obj":"-RRB-"},{"id":"T11862","span":{"begin":366,"end":371},"obj":"VB"},{"id":"T11861","span":{"begin":362,"end":365},"obj":"RB"},{"id":"T11860","span":{"begin":357,"end":361},"obj":"NN"},{"id":"T11859","span":{"begin":356,"end":357},"obj":"-LRB-"},{"id":"T11858","span":{"begin":349,"end":355},"obj":"NN"},{"id":"T11857","span":{"begin":343,"end":348},"obj":"NN"},{"id":"T11856","span":{"begin":340,"end":342},"obj":"IN"},{"id":"T11855","span":{"begin":331,"end":339},"obj":"NN"},{"id":"T11854","span":{"begin":316,"end":330},"obj":"JJ"},{"id":"T11853","span":{"begin":314,"end":315},"obj":"DT"},{"id":"T11852","span":{"begin":307,"end":313},"obj":"VB"},{"id":"T11851","span":{"begin":301,"end":306},"obj":"WDT"},{"id":"T11850","span":{"begin":299,"end":300},"obj":"-COMMA-"},{"id":"T11849","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T11848","span":{"begin":284,"end":288},"obj":"NN"}],"relations":[{"id":"R6340","pred":"arg2Of","subj":"T11797","obj":"T11795"},{"id":"R6341","pred":"arg1Of","subj":"T11797","obj":"T11796"},{"id":"R6342","pred":"arg1Of","subj":"T11797","obj":"T11798"},{"id":"R6343","pred":"arg1Of","subj":"T11797","obj":"T11804"},{"id":"R6344","pred":"arg2Of","subj":"T11799","obj":"T11798"},{"id":"R6345","pred":"arg1Of","subj":"T11799","obj":"T11800"},{"id":"R6346","pred":"arg2Of","subj":"T11801","obj":"T11800"},{"id":"R6347","pred":"arg1Of","subj":"T11801","obj":"T11802"},{"id":"R6348","pred":"arg2Of","subj":"T11803","obj":"T11802"},{"id":"R6349","pred":"arg1Of","subj":"T11805","obj":"T11806"},{"id":"R6350","pred":"arg1Of","subj":"T11806","obj":"T11809"},{"id":"R6351","pred":"arg2Of","subj":"T11807","obj":"T11806"},{"id":"R6352","pred":"arg2Of","subj":"T11809","obj":"T11804"},{"id":"R6353","pred":"arg1Of","subj":"T11809","obj":"T11808"},{"id":"R6354","pred":"arg2Of","subj":"T11810","obj":"T11809"},{"id":"R6355","pred":"arg1Of","subj":"T11812","obj":"T11813"},{"id":"R6356","pred":"arg2Of","subj":"T11812","obj":"T11815"},{"id":"R6357","pred":"arg2Of","subj":"T11815","obj":"T11811"},{"id":"R6358","pred":"arg2Of","subj":"T11815","obj":"T11813"},{"id":"R6359","pred":"arg1Of","subj":"T11815","obj":"T11814"},{"id":"R6360","pred":"arg1Of","subj":"T11815","obj":"T11816"},{"id":"R6361","pred":"arg2Of","subj":"T11818","obj":"T11816"},{"id":"R6362","pred":"arg1Of","subj":"T11818","obj":"T11817"},{"id":"R6363","pred":"modOf","subj":"T11818","obj":"T11819"},{"id":"R6364","pred":"arg1Of","subj":"T11818","obj":"T11820"},{"id":"R6365","pred":"arg2Of","subj":"T11818","obj":"T11821"},{"id":"R6366","pred":"arg1Of","subj":"T11821","obj":"T11819"},{"id":"R6367","pred":"arg2Of","subj":"T11821","obj":"T11820"},{"id":"R6368","pred":"arg1Of","subj":"T11821","obj":"T11822"},{"id":"R6369","pred":"arg1Of","subj":"T11826","obj":"T11821"},{"id":"R6370","pred":"arg2Of","subj":"T11826","obj":"T11823"},{"id":"R6371","pred":"arg2Of","subj":"T11826","obj":"T11824"},{"id":"R6372","pred":"arg1Of","subj":"T11826","obj":"T11825"},{"id":"R6373","pred":"arg1Of","subj":"T11828","obj":"T11829"},{"id":"R6374","pred":"arg1Of","subj":"T11829","obj":"T11811"},{"id":"R6375","pred":"arg1Of","subj":"T11829","obj":"T11827"},{"id":"R6376","pred":"arg1Of","subj":"T11829","obj":"T11845"},{"id":"R6377","pred":"arg2Of","subj":"T11831","obj":"T11829"},{"id":"R6378","pred":"arg1Of","subj":"T11831","obj":"T11830"},{"id":"R6379","pred":"arg1Of","subj":"T11831","obj":"T11832"},{"id":"R6380","pred":"arg2Of","subj":"T11834","obj":"T11832"},{"id":"R6381","pred":"arg1Of","subj":"T11834","obj":"T11833"},{"id":"R6382","pred":"arg1Of","subj":"T11834","obj":"T11835"},{"id":"R6383","pred":"arg1Of","subj":"T11834","obj":"T11837"},{"id":"R6384","pred":"arg2Of","subj":"T11836","obj":"T11835"},{"id":"R6385","pred":"arg1Of","subj":"T11838","obj":"T11839"},{"id":"R6386","pred":"arg1Of","subj":"T11839","obj":"T11841"},{"id":"R6387","pred":"arg2Of","subj":"T11840","obj":"T11839"},{"id":"R6388","pred":"arg2Of","subj":"T11842","obj":"T11841"},{"id":"R6389","pred":"arg2Of","subj":"T11843","obj":"T11837"},{"id":"R6390","pred":"arg1Of","subj":"T11843","obj":"T11838"},{"id":"R6391","pred":"arg1Of","subj":"T11843","obj":"T11840"},{"id":"R6392","pred":"arg1Of","subj":"T11843","obj":"T11842"},{"id":"R6393","pred":"arg3Of","subj":"T11844","obj":"T11837"},{"id":"R6394","pred":"arg2Of","subj":"T11849","obj":"T11845"},{"id":"R6395","pred":"arg1Of","subj":"T11849","obj":"T11846"},{"id":"R6396","pred":"arg1Of","subj":"T11849","obj":"T11847"},{"id":"R6397","pred":"arg1Of","subj":"T11849","obj":"T11848"},{"id":"R6398","pred":"arg1Of","subj":"T11849","obj":"T11850"},{"id":"R6399","pred":"arg1Of","subj":"T11849","obj":"T11851"},{"id":"R6400","pred":"arg1Of","subj":"T11849","obj":"T11852"},{"id":"R6401","pred":"arg2Of","subj":"T11855","obj":"T11852"},{"id":"R6402","pred":"arg1Of","subj":"T11855","obj":"T11853"},{"id":"R6403","pred":"arg1Of","subj":"T11855","obj":"T11854"},{"id":"R6404","pred":"arg1Of","subj":"T11855","obj":"T11856"},{"id":"R6405","pred":"arg2Of","subj":"T11858","obj":"T11856"},{"id":"R6406","pred":"arg1Of","subj":"T11858","obj":"T11857"},{"id":"R6407","pred":"arg1Of","subj":"T11858","obj":"T11859"},{"id":"R6408","pred":"arg2Of","subj":"T11860","obj":"T11859"},{"id":"R6409","pred":"arg2Of","subj":"T11860","obj":"T11862"},{"id":"R6410","pred":"arg1Of","subj":"T11862","obj":"T11861"},{"id":"R6411","pred":"arg3Of","subj":"T11863","obj":"T11859"},{"id":"R6412","pred":"arg2Of","subj":"T11866","obj":"T11864"},{"id":"R6413","pred":"arg1Of","subj":"T11866","obj":"T11865"},{"id":"R6414","pred":"arg1Of","subj":"T11866","obj":"T11867"},{"id":"R6415","pred":"arg2Of","subj":"T11868","obj":"T11867"},{"id":"R6416","pred":"arg1Of","subj":"T11870","obj":"T11871"},{"id":"R6417","pred":"arg1Of","subj":"T11871","obj":"T11864"},{"id":"R6418","pred":"arg1Of","subj":"T11871","obj":"T11869"},{"id":"R6419","pred":"arg1Of","subj":"T11871","obj":"T11874"},{"id":"R6420","pred":"arg2Of","subj":"T11873","obj":"T11871"},{"id":"R6421","pred":"arg1Of","subj":"T11873","obj":"T11872"},{"id":"R6422","pred":"arg2Of","subj":"T11877","obj":"T11874"},{"id":"R6423","pred":"arg1Of","subj":"T11877","obj":"T11875"},{"id":"R6424","pred":"arg1Of","subj":"T11877","obj":"T11876"},{"id":"R6425","pred":"arg1Of","subj":"T11877","obj":"T11878"},{"id":"R6426","pred":"arg2Of","subj":"T11879","obj":"T11878"},{"id":"R6427","pred":"arg2Of","subj":"T11881","obj":"T11880"},{"id":"R6428","pred":"arg1Of","subj":"T11881","obj":"T11882"},{"id":"R6429","pred":"arg2Of","subj":"T11884","obj":"T11882"},{"id":"R6430","pred":"arg1Of","subj":"T11884","obj":"T11883"},{"id":"R6431","pred":"arg1Of","subj":"T11886","obj":"T11888"},{"id":"R6432","pred":"arg1Of","subj":"T11888","obj":"T11880"},{"id":"R6433","pred":"arg1Of","subj":"T11888","obj":"T11885"},{"id":"R6434","pred":"arg1Of","subj":"T11888","obj":"T11887"},{"id":"R6435","pred":"arg1Of","subj":"T11888","obj":"T11895"},{"id":"R6436","pred":"arg2Of","subj":"T11890","obj":"T11888"},{"id":"R6437","pred":"arg1Of","subj":"T11890","obj":"T11889"},{"id":"R6438","pred":"arg1Of","subj":"T11890","obj":"T11892"},{"id":"R6439","pred":"arg1Of","subj":"T11892","obj":"T11891"},{"id":"R6440","pred":"arg2Of","subj":"T11893","obj":"T11892"},{"id":"R6441","pred":"arg1Of","subj":"T11895","obj":"T11894"},{"id":"R6442","pred":"arg1Of","subj":"T11897","obj":"T11896"},{"id":"R6443","pred":"arg1Of","subj":"T11897","obj":"T11898"},{"id":"R6444","pred":"arg1Of","subj":"T11897","obj":"T11902"},{"id":"R6445","pred":"arg1Of","subj":"T11899","obj":"T11900"},{"id":"R6446","pred":"arg2Of","subj":"T11900","obj":"T11898"},{"id":"R6447","pred":"arg2Of","subj":"T11901","obj":"T11900"},{"id":"R6448","pred":"arg2Of","subj":"T11902","obj":"T11895"},{"id":"R6449","pred":"arg1Of","subj":"T11902","obj":"T11905"},{"id":"R6450","pred":"arg1Of","subj":"T11902","obj":"T11909"},{"id":"R6451","pred":"arg2Of","subj":"T11904","obj":"T11902"},{"id":"R6452","pred":"arg1Of","subj":"T11904","obj":"T11903"},{"id":"R6453","pred":"arg2Of","subj":"T11907","obj":"T11905"},{"id":"R6454","pred":"arg1Of","subj":"T11907","obj":"T11906"},{"id":"R6455","pred":"arg3Of","subj":"T11908","obj":"T11905"},{"id":"R6456","pred":"arg2Of","subj":"T11910","obj":"T11909"},{"id":"R6457","pred":"arg1Of","subj":"T11910","obj":"T11911"},{"id":"R6458","pred":"arg2Of","subj":"T11915","obj":"T11914"},{"id":"R6459","pred":"arg1Of","subj":"T11915","obj":"T11916"},{"id":"R6460","pred":"arg2Of","subj":"T11919","obj":"T11916"},{"id":"R6461","pred":"arg1Of","subj":"T11919","obj":"T11917"},{"id":"R6462","pred":"arg1Of","subj":"T11919","obj":"T11918"},{"id":"R6463","pred":"arg1Of","subj":"T11919","obj":"T11921"},{"id":"R6464","pred":"arg1Of","subj":"T11921","obj":"T11920"},{"id":"R6465","pred":"arg2Of","subj":"T11922","obj":"T11921"},{"id":"R6466","pred":"arg1Of","subj":"T11926","obj":"T11915"},{"id":"R6467","pred":"arg2Of","subj":"T11926","obj":"T11924"},{"id":"R6468","pred":"arg1Of","subj":"T11926","obj":"T11925"},{"id":"R6469","pred":"arg1Of","subj":"T11926","obj":"T11927"},{"id":"R6470","pred":"arg1Of","subj":"T11926","obj":"T11929"},{"id":"R6471","pred":"arg1Of","subj":"T11927","obj":"T11912"},{"id":"R6472","pred":"arg1Of","subj":"T11927","obj":"T11913"},{"id":"R6473","pred":"arg1Of","subj":"T11927","obj":"T11914"},{"id":"R6474","pred":"arg1Of","subj":"T11927","obj":"T11923"},{"id":"R6475","pred":"arg2Of","subj":"T11929","obj":"T11927"},{"id":"R6476","pred":"arg1Of","subj":"T11929","obj":"T11928"},{"id":"R6477","pred":"arg1Of","subj":"T11929","obj":"T11930"},{"id":"R6478","pred":"arg1Of","subj":"T11929","obj":"T11935"},{"id":"R6479","pred":"arg2Of","subj":"T11931","obj":"T11930"},{"id":"R6480","pred":"arg1Of","subj":"T11932","obj":"T11933"},{"id":"R6481","pred":"arg2Of","subj":"T11933","obj":"T11931"},{"id":"R6482","pred":"arg2Of","subj":"T11934","obj":"T11933"},{"id":"R6483","pred":"arg1Of","subj":"T11942","obj":"T11939"},{"id":"R6484","pred":"arg1Of","subj":"T11942","obj":"T11940"},{"id":"R6485","pred":"arg1Of","subj":"T11942","obj":"T11941"},{"id":"R6486","pred":"arg2Of","subj":"T11943","obj":"T11935"},{"id":"R6487","pred":"arg1Of","subj":"T11943","obj":"T11936"},{"id":"R6488","pred":"arg1Of","subj":"T11943","obj":"T11937"},{"id":"R6489","pred":"arg1Of","subj":"T11943","obj":"T11938"},{"id":"R6490","pred":"arg1Of","subj":"T11943","obj":"T11942"},{"id":"R6491","pred":"arg1Of","subj":"T11943","obj":"T11944"},{"id":"R6492","pred":"arg2Of","subj":"T11945","obj":"T11944"},{"id":"R6493","pred":"arg1Of","subj":"T11945","obj":"T11946"},{"id":"R6494","pred":"arg1Of","subj":"T11945","obj":"T11947"},{"id":"R6495","pred":"arg3Of","subj":"T11948","obj":"T11935"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T11959","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T11958","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T11957","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T11956","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T11955","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T11954","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T11953","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T11952","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T11951","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T11950","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T11949","span":{"begin":10,"end":15},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T12056","span":{"begin":801,"end":805},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T12055","span":{"begin":576,"end":580},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T12054","span":{"begin":79,"end":83},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T12053","span":{"begin":788,"end":791},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12052","span":{"begin":653,"end":656},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12051","span":{"begin":590,"end":593},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12050","span":{"begin":485,"end":488},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12049","span":{"begin":454,"end":457},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12048","span":{"begin":253,"end":256},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12047","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T12046","span":{"begin":788,"end":791},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12045","span":{"begin":653,"end":656},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12044","span":{"begin":590,"end":593},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12043","span":{"begin":485,"end":488},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12042","span":{"begin":454,"end":457},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12041","span":{"begin":253,"end":256},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12040","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T12039","span":{"begin":788,"end":791},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12038","span":{"begin":653,"end":656},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12037","span":{"begin":590,"end":593},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12036","span":{"begin":485,"end":488},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12035","span":{"begin":454,"end":457},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12034","span":{"begin":253,"end":256},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12033","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T12032","span":{"begin":788,"end":791},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12031","span":{"begin":653,"end":656},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12030","span":{"begin":590,"end":593},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12029","span":{"begin":485,"end":488},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12028","span":{"begin":454,"end":457},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12027","span":{"begin":253,"end":256},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12026","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T12025","span":{"begin":736,"end":741},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12024","span":{"begin":608,"end":613},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12023","span":{"begin":515,"end":520},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12022","span":{"begin":343,"end":348},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12021","span":{"begin":101,"end":106},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T12020","span":{"begin":10,"end":15},"obj":"http://www.uniprot.org/uniprot/Q16552"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"GO-BP","denotations":[{"id":"T11772","span":{"begin":284,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T11771","span":{"begin":736,"end":752},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T11770","span":{"begin":515,"end":531},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T11769","span":{"begin":10,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T11768","span":{"begin":736,"end":752},"obj":"http://purl.obolibrary.org/obo/GO_0032660"},{"id":"T11767","span":{"begin":515,"end":531},"obj":"http://purl.obolibrary.org/obo/GO_0032660"},{"id":"T11766","span":{"begin":10,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0032660"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"GO-MF","denotations":[{"id":"T11965","span":{"begin":736,"end":741},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T11964","span":{"begin":608,"end":613},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T11963","span":{"begin":515,"end":520},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T11962","span":{"begin":343,"end":348},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T11961","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T11960","span":{"begin":10,"end":15},"obj":"http://purl.obolibrary.org/obo/GO_0030367"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"GO-CC","denotations":[{"id":"T11968","span":{"begin":699,"end":703},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11967","span":{"begin":284,"end":288},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11966","span":{"begin":183,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"sentences","denotations":[{"id":"T11765","span":{"begin":664,"end":848},"obj":"Sentence"},{"id":"T11764","span":{"begin":459,"end":663},"obj":"Sentence"},{"id":"T11763","span":{"begin":374,"end":458},"obj":"Sentence"},{"id":"T11762","span":{"begin":93,"end":373},"obj":"Sentence"},{"id":"T11761","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T119","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T120","span":{"begin":93,"end":373},"obj":"Sentence"},{"id":"T121","span":{"begin":374,"end":458},"obj":"Sentence"},{"id":"T122","span":{"begin":459,"end":663},"obj":"Sentence"},{"id":"T123","span":{"begin":664,"end":848},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"simple1","denotations":[{"id":"T12019","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T12018","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12017","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T12016","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T12015","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T12014","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T12013","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T12012","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T12011","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T12010","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T12009","span":{"begin":10,"end":15},"obj":"Protein"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"DLUT931","denotations":[{"id":"T12097","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T12096","span":{"begin":762,"end":772},"obj":"Positive_regulation"},{"id":"T12095","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T12094","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T12093","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T12092","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T12091","span":{"begin":316,"end":330},"obj":"Regulation"},{"id":"T12090","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T12089","span":{"begin":152,"end":160},"obj":"Gene_expression"},{"id":"T12088","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T12087","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T12086","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T12085","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T12084","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12083","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T12082","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T12081","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T12080","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T12079","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T12078","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T12077","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T12076","span":{"begin":10,"end":15},"obj":"Protein"}],"relations":[{"id":"R6519","pred":"themeOf","subj":"T12076","obj":"T12087"},{"id":"R6520","pred":"themeOf","subj":"T12078","obj":"T12087"},{"id":"R6521","pred":"themeOf","subj":"T12079","obj":"T12089"},{"id":"R6522","pred":"themeOf","subj":"T12080","obj":"T12090"},{"id":"R6523","pred":"themeOf","subj":"T12081","obj":"T12092"},{"id":"R6524","pred":"themeOf","subj":"T12083","obj":"T12093"},{"id":"R6525","pred":"themeOf","subj":"T12084","obj":"T12095"},{"id":"R6526","pred":"themeOf","subj":"T12087","obj":"T12088"},{"id":"R6527","pred":"themeOf","subj":"T12087","obj":"T12088"},{"id":"R6528","pred":"themeOf","subj":"T12090","obj":"T12091"},{"id":"R6529","pred":"themeOf","subj":"T12091","obj":"T12090"},{"id":"R6530","pred":"themeOf","subj":"T12092","obj":"T12094"},{"id":"R6531","pred":"themeOf","subj":"T12095","obj":"T12096"},{"id":"R6532","pred":"themeOf","subj":"T12095","obj":"T12097"},{"id":"R6533","pred":"themeOf","subj":"T12097","obj":"T12096"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T12338","span":{"begin":726,"end":752},"obj":"Gene_expression"},{"id":"T12337","span":{"begin":10,"end":34},"obj":"Gene_expression"},{"id":"T12336","span":{"begin":515,"end":537},"obj":"Gene_expression"},{"id":"T12335","span":{"begin":0,"end":66},"obj":"Positive_regulation"},{"id":"T12334","span":{"begin":552,"end":642},"obj":"Gene_expression"},{"id":"T12333","span":{"begin":468,"end":546},"obj":"Positive_regulation"},{"id":"T12332","span":{"begin":726,"end":752},"obj":"Positive_regulation"},{"id":"T12331","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T12330","span":{"begin":697,"end":725},"obj":"Protein"},{"id":"T12329","span":{"begin":171,"end":188},"obj":"Entity"},{"id":"T12328","span":{"begin":52,"end":54},"obj":"Protein"},{"id":"T12327","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T12326","span":{"begin":245,"end":276},"obj":"Protein"},{"id":"T12325","span":{"begin":643,"end":656},"obj":"Protein"},{"id":"T12324","span":{"begin":585,"end":593},"obj":"Protein"},{"id":"T12323","span":{"begin":30,"end":34},"obj":"Entity"},{"id":"T12322","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12321","span":{"begin":603,"end":642},"obj":"Protein"},{"id":"T12320","span":{"begin":449,"end":457},"obj":"Protein"},{"id":"T12319","span":{"begin":480,"end":488},"obj":"Protein"},{"id":"T12318","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T12317","span":{"begin":783,"end":791},"obj":"Protein"},{"id":"T12316","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T12315","span":{"begin":10,"end":15},"obj":"Protein"},{"id":"T12314","span":{"begin":74,"end":84},"obj":"Protein"},{"id":"T12313","span":{"begin":796,"end":805},"obj":"Protein"},{"id":"T12312","span":{"begin":571,"end":580},"obj":"Protein"},{"id":"T12311","span":{"begin":697,"end":720},"obj":"Entity"},{"id":"T12310","span":{"begin":58,"end":66},"obj":"Protein"},{"id":"T12309","span":{"begin":282,"end":288},"obj":"Entity"},{"id":"T12308","span":{"begin":697,"end":703},"obj":"Entity"}],"relations":[{"id":"R6721","pred":"themeOf","subj":"T12315","obj":"T12337"},{"id":"R6722","pred":"themeOf","subj":"T12316","obj":"T12336"},{"id":"R6723","pred":"causeOf","subj":"T12319","obj":"T12333"},{"id":"R6724","pred":"themeOf","subj":"T12321","obj":"T12334"},{"id":"R6725","pred":"themeOf","subj":"T12322","obj":"T12338"},{"id":"R6726","pred":"themeOf","subj":"T12336","obj":"T12333"},{"id":"R6727","pred":"themeOf","subj":"T12337","obj":"T12335"},{"id":"R6728","pred":"themeOf","subj":"T12338","obj":"T12332"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T12190","span":{"begin":390,"end":394},"obj":"DT"},{"id":"T12189","span":{"begin":387,"end":389},"obj":"IN"},{"id":"T12188","span":{"begin":381,"end":386},"obj":"NN"},{"id":"T12187","span":{"begin":377,"end":380},"obj":"DT"},{"id":"T12186","span":{"begin":374,"end":376},"obj":"IN"},{"id":"T12185","span":{"begin":372,"end":373},"obj":"."},{"id":"T12184","span":{"begin":371,"end":372},"obj":"-RRB-"},{"id":"T12183","span":{"begin":366,"end":371},"obj":"VBN"},{"id":"T12182","span":{"begin":362,"end":365},"obj":"RB"},{"id":"T12181","span":{"begin":357,"end":361},"obj":"NNS"},{"id":"T12180","span":{"begin":356,"end":357},"obj":"-LRB-"},{"id":"T12179","span":{"begin":349,"end":355},"obj":"NNS"},{"id":"T12178","span":{"begin":343,"end":348},"obj":"NNP"},{"id":"T12177","span":{"begin":340,"end":342},"obj":"IN"},{"id":"T12176","span":{"begin":331,"end":339},"obj":"NN"},{"id":"T12175","span":{"begin":316,"end":330},"obj":"JJ"},{"id":"T12174","span":{"begin":314,"end":315},"obj":"DT"},{"id":"T12173","span":{"begin":307,"end":313},"obj":"VBD"},{"id":"T12172","span":{"begin":301,"end":306},"obj":"WDT"},{"id":"T12171","span":{"begin":299,"end":300},"obj":","},{"id":"T12170","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T12169","span":{"begin":284,"end":288},"obj":"NN"},{"id":"T12168","span":{"begin":282,"end":283},"obj":"NNP"},{"id":"T12167","span":{"begin":280,"end":281},"obj":"DT"},{"id":"T12166","span":{"begin":277,"end":279},"obj":"IN"},{"id":"T12165","span":{"begin":275,"end":276},"obj":"-RRB-"},{"id":"T12164","span":{"begin":273,"end":275},"obj":"NN"},{"id":"T12163","span":{"begin":272,"end":273},"obj":"NN"},{"id":"T12162","span":{"begin":270,"end":272},"obj":"NN"},{"id":"T12161","span":{"begin":267,"end":269},"obj":"CD"},{"id":"T12160","span":{"begin":263,"end":266},"obj":"CC"},{"id":"T12159","span":{"begin":261,"end":262},"obj":"CD"},{"id":"T12158","span":{"begin":259,"end":260},"obj":","},{"id":"T12157","span":{"begin":258,"end":259},"obj":"CD"},{"id":"T12156","span":{"begin":257,"end":258},"obj":"-LRB-"},{"id":"T12155","span":{"begin":248,"end":256},"obj":"JJ"},{"id":"T12154","span":{"begin":245,"end":247},"obj":"IN"},{"id":"T12153","span":{"begin":230,"end":244},"obj":"NNS"},{"id":"T12152","span":{"begin":220,"end":229},"obj":"JJ"},{"id":"T12151","span":{"begin":217,"end":219},"obj":"IN"},{"id":"T12150","span":{"begin":210,"end":216},"obj":"NN"},{"id":"T12149","span":{"begin":206,"end":209},"obj":"DT"},{"id":"T12148","span":{"begin":193,"end":205},"obj":"VBD"},{"id":"T12147","span":{"begin":190,"end":192},"obj":"PRP"},{"id":"T12146","span":{"begin":188,"end":189},"obj":","},{"id":"T12145","span":{"begin":183,"end":188},"obj":"NNS"},{"id":"T12144","span":{"begin":181,"end":182},"obj":"NNP"},{"id":"T12143","span":{"begin":171,"end":180},"obj":"VBN"},{"id":"T12142","span":{"begin":168,"end":170},"obj":"IN"},{"id":"T12141","span":{"begin":161,"end":167},"obj":"RB"},{"id":"T12140","span":{"begin":152,"end":160},"obj":"VBN"},{"id":"T12139","span":{"begin":149,"end":151},"obj":"VB"},{"id":"T12138","span":{"begin":146,"end":148},"obj":"TO"},{"id":"T12137","span":{"begin":138,"end":145},"obj":"NNS"},{"id":"T12136","span":{"begin":130,"end":137},"obj":"JJR"},{"id":"T12135","span":{"begin":125,"end":129},"obj":"IN"},{"id":"T12134","span":{"begin":119,"end":124},"obj":"VBN"},{"id":"T12133","span":{"begin":111,"end":118},"obj":"RB"},{"id":"T12132","span":{"begin":107,"end":110},"obj":"VBD"},{"id":"T12131","span":{"begin":101,"end":106},"obj":"NNP"},{"id":"T12130","span":{"begin":93,"end":100},"obj":"IN"},{"id":"T12129","span":{"begin":89,"end":92},"obj":"NNP"},{"id":"T12128","span":{"begin":85,"end":88},"obj":"CC"},{"id":"T12127","span":{"begin":83,"end":84},"obj":","},{"id":"T12126","span":{"begin":74,"end":83},"obj":"JJ"},{"id":"T12125","span":{"begin":67,"end":73},"obj":"CC"},{"id":"T12124","span":{"begin":58,"end":66},"obj":"JJ"},{"id":"T12123","span":{"begin":55,"end":57},"obj":"IN"},{"id":"T12122","span":{"begin":52,"end":54},"obj":"NNP"},{"id":"T12121","span":{"begin":47,"end":51},"obj":"IN"},{"id":"T12120","span":{"begin":38,"end":46},"obj":"NNS"},{"id":"T12119","span":{"begin":35,"end":37},"obj":"IN"},{"id":"T12118","span":{"begin":30,"end":34},"obj":"NNP"},{"id":"T12117","span":{"begin":27,"end":29},"obj":"IN"},{"id":"T12116","span":{"begin":16,"end":26},"obj":"NN"},{"id":"T12115","span":{"begin":10,"end":15},"obj":"JJ"},{"id":"T12114","span":{"begin":0,"end":9},"obj":"VBN"},{"id":"T12278","span":{"begin":847,"end":848},"obj":"."},{"id":"T12277","span":{"begin":846,"end":847},"obj":"-RRB-"},{"id":"T12276","span":{"begin":842,"end":846},"obj":"CD"},{"id":"T12275","span":{"begin":840,"end":841},"obj":"NNP"},{"id":"T12274","span":{"begin":838,"end":839},"obj":"NNP"},{"id":"T12273","span":{"begin":836,"end":837},"obj":":"},{"id":"T12272","span":{"begin":831,"end":836},"obj":"NN"},{"id":"T12271","span":{"begin":829,"end":830},"obj":"CD"},{"id":"T12270","span":{"begin":827,"end":828},"obj":"CD"},{"id":"T12269","span":{"begin":823,"end":826},"obj":"CD"},{"id":"T12268","span":{"begin":816,"end":822},"obj":"IN"},{"id":"T12267","span":{"begin":813,"end":815},"obj":"CD"},{"id":"T12266","span":{"begin":811,"end":812},"obj":"CD"},{"id":"T12265","span":{"begin":807,"end":810},"obj":"CD"},{"id":"T12264","span":{"begin":806,"end":807},"obj":"-LRB-"},{"id":"T12263","span":{"begin":796,"end":805},"obj":"JJ"},{"id":"T12262","span":{"begin":792,"end":795},"obj":"CC"},{"id":"T12261","span":{"begin":783,"end":791},"obj":"JJ"},{"id":"T12260","span":{"begin":778,"end":782},"obj":"IN"},{"id":"T12259","span":{"begin":773,"end":777},"obj":"IN"},{"id":"T12258","span":{"begin":762,"end":772},"obj":"JJ"},{"id":"T12257","span":{"begin":757,"end":761},"obj":"RBR"},{"id":"T12256","span":{"begin":753,"end":756},"obj":"VBD"},{"id":"T12255","span":{"begin":742,"end":752},"obj":"NN"},{"id":"T12254","span":{"begin":736,"end":741},"obj":"NNP"},{"id":"T12253","span":{"begin":726,"end":735},"obj":"VBD"},{"id":"T12252","span":{"begin":724,"end":725},"obj":","},{"id":"T12251","span":{"begin":721,"end":724},"obj":"NNP"},{"id":"T12250","span":{"begin":718,"end":720},"obj":"IN"},{"id":"T12249","span":{"begin":713,"end":717},"obj":"JJ"},{"id":"T12248","span":{"begin":704,"end":712},"obj":"NNS"},{"id":"T12247","span":{"begin":699,"end":703},"obj":"NN"},{"id":"T12246","span":{"begin":697,"end":698},"obj":"NNP"},{"id":"T12245","span":{"begin":692,"end":696},"obj":"IN"},{"id":"T12244","span":{"begin":682,"end":691},"obj":"VBN"},{"id":"T12243","span":{"begin":677,"end":681},"obj":"WRB"},{"id":"T12242","span":{"begin":675,"end":676},"obj":","},{"id":"T12241","span":{"begin":664,"end":675},"obj":"RB"},{"id":"T12240","span":{"begin":662,"end":663},"obj":"."},{"id":"T12239","span":{"begin":657,"end":662},"obj":"RB"},{"id":"T12238","span":{"begin":648,"end":656},"obj":"JJ"},{"id":"T12237","span":{"begin":643,"end":647},"obj":"IN"},{"id":"T12236","span":{"begin":641,"end":642},"obj":"-RRB-"},{"id":"T12235","span":{"begin":637,"end":641},"obj":"VB"},{"id":"T12234","span":{"begin":636,"end":637},"obj":":"},{"id":"T12233","span":{"begin":634,"end":636},"obj":"SYM"},{"id":"T12232","span":{"begin":629,"end":634},"obj":"CD"},{"id":"T12231","span":{"begin":615,"end":628},"obj":"RB"},{"id":"T12230","span":{"begin":614,"end":615},"obj":"-LRB-"},{"id":"T12229","span":{"begin":608,"end":613},"obj":"JJ"},{"id":"T12228","span":{"begin":603,"end":607},"obj":"RBR"},{"id":"T12227","span":{"begin":594,"end":602},"obj":"VBN"},{"id":"T12226","span":{"begin":585,"end":593},"obj":"JJ"},{"id":"T12225","span":{"begin":581,"end":584},"obj":"CC"},{"id":"T12224","span":{"begin":571,"end":580},"obj":"JJ"},{"id":"T12223","span":{"begin":568,"end":570},"obj":"IN"},{"id":"T12222","span":{"begin":556,"end":567},"obj":"NN"},{"id":"T12221","span":{"begin":552,"end":555},"obj":"DT"},{"id":"T12220","span":{"begin":548,"end":551},"obj":"CC"},{"id":"T12219","span":{"begin":546,"end":547},"obj":","},{"id":"T12218","span":{"begin":538,"end":546},"obj":"CD"},{"id":"T12217","span":{"begin":535,"end":537},"obj":"TO"},{"id":"T12216","span":{"begin":532,"end":534},"obj":"IN"},{"id":"T12215","span":{"begin":521,"end":531},"obj":"NN"},{"id":"T12214","span":{"begin":515,"end":520},"obj":"NN"},{"id":"T12213","span":{"begin":503,"end":514},"obj":"JJ"},{"id":"T12212","span":{"begin":489,"end":502},"obj":"RB"},{"id":"T12211","span":{"begin":480,"end":488},"obj":"JJ"},{"id":"T12210","span":{"begin":478,"end":479},"obj":","},{"id":"T12209","span":{"begin":477,"end":478},"obj":"CD"},{"id":"T12208","span":{"begin":471,"end":476},"obj":"NNP"},{"id":"T12207","span":{"begin":468,"end":470},"obj":"IN"},{"id":"T12206","span":{"begin":462,"end":467},"obj":"VBN"},{"id":"T12205","span":{"begin":459,"end":461},"obj":"IN"},{"id":"T12204","span":{"begin":457,"end":458},"obj":"."},{"id":"T12203","span":{"begin":449,"end":457},"obj":"JJ"},{"id":"T12202","span":{"begin":445,"end":448},"obj":"IN"},{"id":"T12201","span":{"begin":431,"end":444},"obj":"NN"},{"id":"T12200","span":{"begin":419,"end":430},"obj":"NN"},{"id":"T12199","span":{"begin":417,"end":418},"obj":"DT"},{"id":"T12198","span":{"begin":414,"end":416},"obj":"IN"},{"id":"T12197","span":{"begin":411,"end":413},"obj":"NN"},{"id":"T12196","span":{"begin":410,"end":411},"obj":"NN"},{"id":"T12195","span":{"begin":408,"end":410},"obj":"NN"},{"id":"T12194","span":{"begin":405,"end":407},"obj":"CD"},{"id":"T12193","span":{"begin":399,"end":404},"obj":"VBD"},{"id":"T12192","span":{"begin":396,"end":398},"obj":"PRP"},{"id":"T12191","span":{"begin":394,"end":395},"obj":","}],"relations":[{"id":"R6542","pred":"amod","subj":"T12114","obj":"T12116"},{"id":"R6543","pred":"amod","subj":"T12115","obj":"T12116"},{"id":"R6544","pred":"nsubj","subj":"T12116","obj":"T12148"},{"id":"R6545","pred":"prep","subj":"T12117","obj":"T12116"},{"id":"R6546","pred":"pobj","subj":"T12118","obj":"T12117"},{"id":"R6547","pred":"prep","subj":"T12119","obj":"T12118"},{"id":"R6548","pred":"pobj","subj":"T12120","obj":"T12119"},{"id":"R6549","pred":"prep","subj":"T12121","obj":"T12120"},{"id":"R6550","pred":"pobj","subj":"T12122","obj":"T12121"},{"id":"R6551","pred":"prep","subj":"T12123","obj":"T12116"},{"id":"R6552","pred":"advcl","subj":"T12124","obj":"T12148"},{"id":"R6553","pred":"cc","subj":"T12125","obj":"T12124"},{"id":"R6554","pred":"conj","subj":"T12126","obj":"T12124"},{"id":"R6555","pred":"punct","subj":"T12127","obj":"T12126"},{"id":"R6556","pred":"cc","subj":"T12128","obj":"T12124"},{"id":"R6557","pred":"conj","subj":"T12129","obj":"T12124"},{"id":"R6558","pred":"mark","subj":"T12130","obj":"T12134"},{"id":"R6559","pred":"nsubjpass","subj":"T12131","obj":"T12134"},{"id":"R6560","pred":"auxpass","subj":"T12132","obj":"T12134"},{"id":"R6561","pred":"advmod","subj":"T12133","obj":"T12134"},{"id":"R6562","pred":"advcl","subj":"T12134","obj":"T12148"},{"id":"R6563","pred":"prep","subj":"T12135","obj":"T12134"},{"id":"R6564","pred":"amod","subj":"T12136","obj":"T12137"},{"id":"R6565","pred":"pobj","subj":"T12137","obj":"T12135"},{"id":"R6566","pred":"aux","subj":"T12138","obj":"T12140"},{"id":"R6567","pred":"auxpass","subj":"T12139","obj":"T12140"},{"id":"R6568","pred":"acl","subj":"T12140","obj":"T12137"},{"id":"R6569","pred":"advmod","subj":"T12141","obj":"T12140"},{"id":"R6570","pred":"agent","subj":"T12142","obj":"T12140"},{"id":"R6571","pred":"amod","subj":"T12143","obj":"T12145"},{"id":"R6572","pred":"compound","subj":"T12144","obj":"T12145"},{"id":"R6573","pred":"pobj","subj":"T12145","obj":"T12142"},{"id":"R6574","pred":"punct","subj":"T12146","obj":"T12148"},{"id":"R6575","pred":"nsubj","subj":"T12147","obj":"T12148"},{"id":"R6576","pred":"ROOT","subj":"T12148","obj":"T12148"},{"id":"R6577","pred":"det","subj":"T12149","obj":"T12150"},{"id":"R6578","pred":"dobj","subj":"T12150","obj":"T12148"},{"id":"R6579","pred":"prep","subj":"T12151","obj":"T12150"},{"id":"R6580","pred":"amod","subj":"T12152","obj":"T12153"},{"id":"R6581","pred":"pobj","subj":"T12153","obj":"T12151"},{"id":"R6582","pred":"prep","subj":"T12154","obj":"T12153"},{"id":"R6583","pred":"pobj","subj":"T12155","obj":"T12154"},{"id":"R6584","pred":"punct","subj":"T12156","obj":"T12164"},{"id":"R6585","pred":"nummod","subj":"T12157","obj":"T12162"},{"id":"R6586","pred":"punct","subj":"T12158","obj":"T12159"},{"id":"R6587","pred":"prep","subj":"T12159","obj":"T12157"},{"id":"R6588","pred":"cc","subj":"T12160","obj":"T12157"},{"id":"R6589","pred":"conj","subj":"T12161","obj":"T12157"},{"id":"R6590","pred":"nmod","subj":"T12162","obj":"T12164"},{"id":"R6591","pred":"compound","subj":"T12163","obj":"T12164"},{"id":"R6592","pred":"appos","subj":"T12164","obj":"T12155"},{"id":"R6593","pred":"punct","subj":"T12165","obj":"T12164"},{"id":"R6594","pred":"prep","subj":"T12166","obj":"T12148"},{"id":"R6595","pred":"det","subj":"T12167","obj":"T12170"},{"id":"R6596","pred":"compound","subj":"T12168","obj":"T12170"},{"id":"R6597","pred":"compound","subj":"T12169","obj":"T12170"},{"id":"R6598","pred":"pobj","subj":"T12170","obj":"T12166"},{"id":"R6599","pred":"punct","subj":"T12171","obj":"T12170"},{"id":"R6600","pred":"nsubj","subj":"T12172","obj":"T12173"},{"id":"R6601","pred":"relcl","subj":"T12173","obj":"T12170"},{"id":"R6602","pred":"det","subj":"T12174","obj":"T12176"},{"id":"R6603","pred":"amod","subj":"T12175","obj":"T12176"},{"id":"R6604","pred":"dobj","subj":"T12176","obj":"T12173"},{"id":"R6605","pred":"prep","subj":"T12177","obj":"T12176"},{"id":"R6606","pred":"compound","subj":"T12178","obj":"T12179"},{"id":"R6607","pred":"pobj","subj":"T12179","obj":"T12177"},{"id":"R6608","pred":"punct","subj":"T12180","obj":"T12179"},{"id":"R6609","pred":"appos","subj":"T12181","obj":"T12179"},{"id":"R6610","pred":"neg","subj":"T12182","obj":"T12183"},{"id":"R6611","pred":"acl","subj":"T12183","obj":"T12181"},{"id":"R6612","pred":"punct","subj":"T12184","obj":"T12181"},{"id":"R6613","pred":"punct","subj":"T12185","obj":"T12148"},{"id":"R6614","pred":"prep","subj":"T12186","obj":"T12193"},{"id":"R6615","pred":"det","subj":"T12187","obj":"T12188"},{"id":"R6616","pred":"pobj","subj":"T12188","obj":"T12186"},{"id":"R6617","pred":"prep","subj":"T12189","obj":"T12188"},{"id":"R6618","pred":"pobj","subj":"T12190","obj":"T12189"},{"id":"R6619","pred":"punct","subj":"T12191","obj":"T12193"},{"id":"R6620","pred":"nsubj","subj":"T12192","obj":"T12193"},{"id":"R6621","pred":"ROOT","subj":"T12193","obj":"T12193"},{"id":"R6622","pred":"nummod","subj":"T12194","obj":"T12195"},{"id":"R6623","pred":"compound","subj":"T12195","obj":"T12197"},{"id":"R6624","pred":"compound","subj":"T12196","obj":"T12197"},{"id":"R6625","pred":"dobj","subj":"T12197","obj":"T12193"},{"id":"R6626","pred":"prep","subj":"T12198","obj":"T12193"},{"id":"R6627","pred":"det","subj":"T12199","obj":"T12201"},{"id":"R6628","pred":"compound","subj":"T12200","obj":"T12201"},{"id":"R6629","pred":"pobj","subj":"T12201","obj":"T12198"},{"id":"R6630","pred":"prep","subj":"T12202","obj":"T12201"},{"id":"R6631","pred":"pobj","subj":"T12203","obj":"T12202"},{"id":"R6632","pred":"punct","subj":"T12204","obj":"T12193"},{"id":"R6633","pred":"mark","subj":"T12205","obj":"T12206"},{"id":"R6634","pred":"advcl","subj":"T12206","obj":"T12227"},{"id":"R6635","pred":"prep","subj":"T12207","obj":"T12206"},{"id":"R6636","pred":"pobj","subj":"T12208","obj":"T12207"},{"id":"R6637","pred":"nummod","subj":"T12209","obj":"T12208"},{"id":"R6638","pred":"punct","subj":"T12210","obj":"T12227"},{"id":"R6639","pred":"nmod","subj":"T12211","obj":"T12215"},{"id":"R6640","pred":"advmod","subj":"T12212","obj":"T12213"},{"id":"R6641","pred":"nmod","subj":"T12213","obj":"T12215"},{"id":"R6642","pred":"compound","subj":"T12214","obj":"T12215"},{"id":"R6643","pred":"nsubj","subj":"T12215","obj":"T12227"},{"id":"R6644","pred":"prep","subj":"T12216","obj":"T12215"},{"id":"R6645","pred":"prep","subj":"T12217","obj":"T12216"},{"id":"R6646","pred":"pobj","subj":"T12218","obj":"T12217"},{"id":"R6647","pred":"punct","subj":"T12219","obj":"T12215"},{"id":"R6648","pred":"cc","subj":"T12220","obj":"T12215"},{"id":"R6649","pred":"det","subj":"T12221","obj":"T12222"},{"id":"R6650","pred":"conj","subj":"T12222","obj":"T12215"},{"id":"R6651","pred":"prep","subj":"T12223","obj":"T12222"},{"id":"R6652","pred":"amod","subj":"T12224","obj":"T12227"},{"id":"R6653","pred":"cc","subj":"T12225","obj":"T12224"},{"id":"R6654","pred":"conj","subj":"T12226","obj":"T12224"},{"id":"R6655","pred":"ROOT","subj":"T12227","obj":"T12227"},{"id":"R6656","pred":"advmod","subj":"T12228","obj":"T12229"},{"id":"R6657","pred":"dobj","subj":"T12229","obj":"T12227"},{"id":"R6658","pred":"punct","subj":"T12230","obj":"T12235"},{"id":"R6659","pred":"advmod","subj":"T12231","obj":"T12232"},{"id":"R6660","pred":"nummod","subj":"T12232","obj":"T12235"},{"id":"R6661","pred":"punct","subj":"T12233","obj":"T12235"},{"id":"R6662","pred":"punct","subj":"T12234","obj":"T12235"},{"id":"R6663","pred":"appos","subj":"T12235","obj":"T12229"},{"id":"R6664","pred":"punct","subj":"T12236","obj":"T12235"},{"id":"R6665","pred":"prep","subj":"T12237","obj":"T12229"},{"id":"R6666","pred":"pobj","subj":"T12238","obj":"T12237"},{"id":"R6667","pred":"advmod","subj":"T12239","obj":"T12238"},{"id":"R6668","pred":"punct","subj":"T12240","obj":"T12227"},{"id":"R6669","pred":"advmod","subj":"T12241","obj":"T12253"},{"id":"R6670","pred":"punct","subj":"T12242","obj":"T12253"},{"id":"R6671","pred":"advmod","subj":"T12243","obj":"T12244"},{"id":"R6672","pred":"advcl","subj":"T12244","obj":"T12253"},{"id":"R6673","pred":"prep","subj":"T12245","obj":"T12244"},{"id":"R6674","pred":"compound","subj":"T12246","obj":"T12247"},{"id":"R6675","pred":"compound","subj":"T12247","obj":"T12248"},{"id":"R6676","pred":"pobj","subj":"T12248","obj":"T12245"},{"id":"R6677","pred":"amod","subj":"T12249","obj":"T12250"},{"id":"R6678","pred":"prep","subj":"T12250","obj":"T12248"},{"id":"R6679","pred":"pobj","subj":"T12251","obj":"T12250"},{"id":"R6680","pred":"punct","subj":"T12252","obj":"T12253"},{"id":"R6681","pred":"amod","subj":"T12253","obj":"T12255"},{"id":"R6682","pred":"compound","subj":"T12254","obj":"T12255"},{"id":"R6683","pred":"nsubj","subj":"T12255","obj":"T12256"},{"id":"R6684","pred":"ROOT","subj":"T12256","obj":"T12256"},{"id":"R6685","pred":"advmod","subj":"T12257","obj":"T12258"},{"id":"R6686","pred":"acomp","subj":"T12258","obj":"T12256"},{"id":"R6687","pred":"prep","subj":"T12259","obj":"T12258"},{"id":"R6688","pred":"prep","subj":"T12260","obj":"T12259"},{"id":"R6689","pred":"pobj","subj":"T12261","obj":"T12260"},{"id":"R6690","pred":"cc","subj":"T12262","obj":"T12261"},{"id":"R6691","pred":"conj","subj":"T12263","obj":"T12261"},{"id":"R6692","pred":"punct","subj":"T12264","obj":"T12263"},{"id":"R6693","pred":"nummod","subj":"T12265","obj":"T12266"},{"id":"R6694","pred":"appos","subj":"T12266","obj":"T12263"},{"id":"R6695","pred":"nummod","subj":"T12267","obj":"T12266"},{"id":"R6696","pred":"prep","subj":"T12268","obj":"T12267"},{"id":"R6697","pred":"nummod","subj":"T12269","obj":"T12272"},{"id":"R6698","pred":"nmod","subj":"T12270","obj":"T12272"},{"id":"R6699","pred":"nummod","subj":"T12271","obj":"T12272"},{"id":"R6700","pred":"pobj","subj":"T12272","obj":"T12268"},{"id":"R6701","pred":"punct","subj":"T12273","obj":"T12276"},{"id":"R6702","pred":"compound","subj":"T12274","obj":"T12275"},{"id":"R6703","pred":"compound","subj":"T12275","obj":"T12276"},{"id":"R6704","pred":"npadvmod","subj":"T12276","obj":"T12256"},{"id":"R6705","pred":"punct","subj":"T12277","obj":"T12276"},{"id":"R6706","pred":"punct","subj":"T12278","obj":"T12256"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T12008","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T12007","span":{"begin":773,"end":777},"obj":"Binding"},{"id":"T12006","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T12005","span":{"begin":796,"end":805},"obj":"Protein"},{"id":"T12004","span":{"begin":783,"end":791},"obj":"Protein"},{"id":"T12003","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T12002","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T12001","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T12000","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T11999","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T11998","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T11997","span":{"begin":653,"end":656},"obj":"Protein"},{"id":"T11996","span":{"begin":603,"end":613},"obj":"Protein"},{"id":"T11995","span":{"begin":585,"end":593},"obj":"Protein"},{"id":"T11994","span":{"begin":571,"end":580},"obj":"Protein"},{"id":"T11993","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T11992","span":{"begin":480,"end":488},"obj":"Protein"},{"id":"T11991","span":{"begin":471,"end":478},"obj":"Protein"},{"id":"T11990","span":{"begin":449,"end":457},"obj":"Protein"},{"id":"T11989","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T11988","span":{"begin":152,"end":160},"obj":"Gene_expression"},{"id":"T11987","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T11986","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T11985","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T11984","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T11983","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T11982","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T11981","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T11980","span":{"begin":63,"end":66},"obj":"Protein"}],"relations":[{"id":"R6497","pred":"themeOf","subj":"T11980","obj":"T11982"},{"id":"R6498","pred":"themeOf","subj":"T11981","obj":"T11983"},{"id":"R6499","pred":"themeOf","subj":"T11982","obj":"T11984"},{"id":"R6500","pred":"themeOf","subj":"T11983","obj":"T11985"},{"id":"R6501","pred":"themeOf","subj":"T11986","obj":"T11988"},{"id":"R6502","pred":"themeOf","subj":"T11987","obj":"T11989"},{"id":"R6503","pred":"causeOf","subj":"T11992","obj":"T12001"},{"id":"R6504","pred":"themeOf","subj":"T11993","obj":"T11998"},{"id":"R6505","pred":"themeOf","subj":"T11996","obj":"T11999"},{"id":"R6506","pred":"themeOf","subj":"T11997","obj":"T12000"},{"id":"R6507","pred":"themeOf","subj":"T11998","obj":"T12001"},{"id":"R6508","pred":"themeOf","subj":"T12003","obj":"T12006"},{"id":"R6509","pred":"themeOf","subj":"T12004","obj":"T12007"},{"id":"R6510","pred":"themeOf","subj":"T12006","obj":"T12008"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}

{"project":"testone","denotations":[{"id":"T11645","span":{"begin":742,"end":752},"obj":"Gene_expression"},{"id":"T11644","span":{"begin":726,"end":735},"obj":"Positive_regulation"},{"id":"T11643","span":{"begin":594,"end":602},"obj":"Gene_expression"},{"id":"T11642","span":{"begin":521,"end":531},"obj":"Gene_expression"},{"id":"T11641","span":{"begin":503,"end":514},"obj":"Positive_regulation"},{"id":"T11640","span":{"begin":331,"end":339},"obj":"Positive_regulation"},{"id":"T11639","span":{"begin":152,"end":160},"obj":"Gene_expression"},{"id":"T11638","span":{"begin":16,"end":26},"obj":"Gene_expression"},{"id":"T11637","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T11636","span":{"begin":801,"end":805},"obj":"Protein"},{"id":"T11635","span":{"begin":736,"end":741},"obj":"Protein"},{"id":"T11634","span":{"begin":721,"end":724},"obj":"Protein"},{"id":"T11633","span":{"begin":608,"end":613},"obj":"Protein"},{"id":"T11632","span":{"begin":576,"end":580},"obj":"Protein"},{"id":"T11631","span":{"begin":515,"end":520},"obj":"Protein"},{"id":"T11630","span":{"begin":343,"end":348},"obj":"Protein"},{"id":"T11629","span":{"begin":101,"end":106},"obj":"Protein"},{"id":"T11628","span":{"begin":89,"end":92},"obj":"Protein"},{"id":"T11627","span":{"begin":79,"end":83},"obj":"Protein"},{"id":"T11626","span":{"begin":10,"end":15},"obj":"Protein"}],"relations":[{"id":"R6306","pred":"themeOf","subj":"T11626","obj":"T11638"},{"id":"R6307","pred":"causeOf","subj":"T11628","obj":"T11637"},{"id":"R6308","pred":"themeOf","subj":"T11629","obj":"T11639"},{"id":"R6309","pred":"themeOf","subj":"T11630","obj":"T11640"},{"id":"R6310","pred":"themeOf","subj":"T11631","obj":"T11642"},{"id":"R6311","pred":"themeOf","subj":"T11633","obj":"T11643"},{"id":"R6312","pred":"causeOf","subj":"T11634","obj":"T11644"},{"id":"R6313","pred":"themeOf","subj":"T11635","obj":"T11645"},{"id":"R6314","pred":"themeOf","subj":"T11638","obj":"T11637"},{"id":"R6315","pred":"themeOf","subj":"T11642","obj":"T11641"},{"id":"R6316","pred":"themeOf","subj":"T11645","obj":"T11644"}],"text":"Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA\nBecause IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown). On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3. As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone. Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P \u003c 0.05)."}