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test3

Id Subject Object Predicate Lexical cue
T93 10-24 Protein denotes interleukin-17
T94 68-71 Protein denotes Akt
T128 0-9 Positive_regulation denotes Increased
T129 10-24 Protein denotes interleukin-17
T130 25-35 Gene_expression denotes production
T131 68-71 Protein denotes Akt
T22090 28675-28680 Protein denotes IL-17
T22089 28503-28513 Gene_expression denotes production
T22088 28497-28502 Protein denotes IL-17
T22087 28483-28493 Regulation denotes regulation
T22086 28380-28383 Protein denotes Akt
T22085 28286-28291 Protein denotes IL-17
T22084 28270-28282 Positive_regulation denotes upregulation
T22083 28240-28244 Protein denotes CD28
T22082 28194-28199 Protein denotes MCP-1
T22081 28184-28189 Protein denotes IL-15
T22080 28150-28155 Protein denotes IL-17
T22079 28136-28146 Gene_expression denotes production
T22078 28675-28680 Protein denotes IL-17
T22077 28497-28502 Protein denotes IL-17
T22076 28380-28383 Protein denotes Akt
T22075 28286-28291 Protein denotes IL-17
T22074 28240-28244 Protein denotes CD28
T22073 28194-28199 Protein denotes MCP-1
T22072 28184-28189 Protein denotes IL-15
T22071 28150-28155 Protein denotes IL-17
T17221 27996-28001 Protein denotes IL-17
T17220 27915-27920 Protein denotes IL-17
T17219 27808-27816 Entity denotes promoter
T17218 27802-27807 Protein denotes IL-17
T17217 27778-27785 Binding denotes binding
T17216 27694-27699 Protein denotes IL-17
T17215 27678-27690 Positive_regulation denotes upregulation
T17214 27603-27606 Protein denotes Akt
T17213 27554-27561 Negative_regulation denotes lacking
T17212 27544-27549 Protein denotes IL-17
T17211 27535-27543 Positive_regulation denotes inducing
T17210 27420-27431 Binding denotes association
T17209 27413-27416 Protein denotes Akt
T17208 27222-27226 Protein denotes AP-1
T17207 27187-27192 Protein denotes IL-17
T17206 27174-27183 Positive_regulation denotes induction
T17205 27062-27067 Protein denotes IL-15
T17204 27056-27060 Protein denotes CD28
T17203 27029-27038 Positive_regulation denotes activated
T17202 26976-26981 Protein denotes IL-17
T17201 26963-26972 Positive_regulation denotes induction
T17200 26873-26887 Phosphorylation denotes phosphorylated
T17199 26866-26869 Protein denotes Akt
T17198 26823-26827 Negative_regulation denotes loss
T17197 26788-26798 Positive_regulation denotes activation
T17196 26784-26787 Protein denotes Akt
T17195 26649-26659 Gene_expression denotes production
T17194 26643-26648 Protein denotes IL-17
T17193 26487-26496 Negative_regulation denotes decreased
T17192 26466-26473 Binding denotes binding
T17191 26349-26369 Protein denotes CREB-binding protein
T17190 26344-26348 Protein denotes p300
T17189 26236-26245 Positive_regulation denotes activated
T17188 26220-26232 Protein denotes IκB kinase-β
T17187 26110-26119 Negative_regulation denotes inhibitor
T17186 26056-26069 Negative_regulation denotes downregulated
T17185 26041-26051 Gene_expression denotes production
T17184 26035-26040 Protein denotes IL-17
T17183 26027-26034 Positive_regulation denotes induced
T17182 25868-25876 Negative_regulation denotes hampered
T17181 25828-25838 Gene_expression denotes production
T17180 25822-25827 Protein denotes IL-17
T17179 25814-25821 Positive_regulation denotes induced
T17178 25810-25813 Protein denotes CD3
T17177 25768-25773 Protein denotes IL-17
T17176 25755-25764 Positive_regulation denotes induction
T17175 25739-25747 Regulation denotes involved
T17174 25600-25609 Regulation denotes regulated
T17173 25582-25592 Gene_expression denotes production
T17172 25576-25581 Protein denotes IL-17
T17171 25497-25502 Protein denotes IL-17
T17170 25399-25408 Positive_regulation denotes induction
T17169 25393-25398 Protein denotes IL-17
T17168 25383-25392 Positive_regulation denotes increases
T17167 25373-25377 Protein denotes CD28
T17166 25139-25144 Protein denotes MCP-1
T17165 25080-25085 Protein denotes TNF-α
T17164 25056-25066 Gene_expression denotes production
T17163 25050-25055 Protein denotes IL-17
T17162 25031-25040 Positive_regulation denotes triggered
T17161 25025-25030 Protein denotes IL-15
T17160 24962-24972 Gene_expression denotes production
T17159 24956-24961 Protein denotes IL-17
T17158 24949-24955 Regulation denotes affect
T17157 24917-24926 Positive_regulation denotes increased
T17156 24849-24854 Protein denotes TNF-α
T17155 24840-24844 Protein denotes IL-1
T17154 24801-24811 Gene_expression denotes production
T17153 24795-24800 Protein denotes IL-17
T17152 24785-24794 Positive_regulation denotes augmented
T17151 24763-24768 Protein denotes MCP-1
T17150 24754-24759 Protein denotes IL-15
T17149 24729-24734 Protein denotes IL-17
T17148 24715-24725 Gene_expression denotes production
T17147 24701-24710 Positive_regulation denotes increased
T17146 24657-24662 Protein denotes MCP-1
T17145 24647-24652 Protein denotes IL-15
T17144 24611-24615 Protein denotes CD28
T17143 24471-24476 Protein denotes IL-17
T17142 24457-24467 Gene_expression denotes production
T17141 24398-24408 Gene_expression denotes production
T17140 24392-24397 Protein denotes IL-17
T17139 24383-24391 Regulation denotes regulate
T17130 24051-24056 Protein denotes IL-17
T17129 23770-23779 Positive_regulation denotes augmented
T17128 23741-23751 Gene_expression denotes production
T17127 23735-23740 Protein denotes IL-17
T17126 23652-23657 Protein denotes IL-23
T17125 23632-23635 Protein denotes CD8
T17124 23620-23628 Gene_expression denotes produced
T17123 23524-23527 Protein denotes CD4
T17122 23495-23503 Gene_expression denotes produced
T17121 23486-23491 Protein denotes IL-17
T17120 23412-23415 Positive_regulation denotes due
T17119 23397-23402 Protein denotes IL-17
T17118 23381-23393 Positive_regulation denotes upregulation
T17117 23295-23304 Regulation denotes dependent
T17116 23261-23271 Gene_expression denotes production
T17115 23255-23260 Protein denotes IL-17
T17114 23245-23254 Positive_regulation denotes increased
T17113 23197-23201 Protein denotes CD28
T17112 23155-23158 Protein denotes PHA
T17111 23089-23093 Protein denotes CD28
T17110 23045-23055 Gene_expression denotes production
T17109 23039-23044 Protein denotes IL-17
T17108 22991-23001 Gene_expression denotes production
T17107 22985-22990 Protein denotes IL-17
T17106 22975-22984 Positive_regulation denotes stimulate
T17105 22835-22840 Protein denotes IL-17
T17104 22766-22775 Regulation denotes regulated
T17103 22752-22762 Gene_expression denotes production
T17102 22746-22751 Protein denotes IL-17
T17101 22594-22599 Protein denotes IL-17
T17100 22349-22361 Protein denotes interferon-γ
T17099 22340-22344 Protein denotes IL-4
T17098 22248-22253 Protein denotes TNF-α
T17097 22239-22243 Protein denotes IL-1
T17096 22004-22009 Protein denotes IL-17
T17095 27996-28001 Protein denotes IL-17
T17094 27915-27920 Protein denotes IL-17
T17093 27802-27807 Protein denotes IL-17
T17092 27694-27699 Protein denotes IL-17
T17091 27603-27606 Protein denotes Akt
T17090 27544-27549 Protein denotes IL-17
T17089 27413-27416 Protein denotes Akt
T17088 27222-27226 Protein denotes AP-1
T17087 27187-27192 Protein denotes IL-17
T17086 27062-27067 Protein denotes IL-15
T17085 27056-27060 Protein denotes CD28
T17084 26976-26981 Protein denotes IL-17
T17083 26866-26869 Protein denotes Akt
T17082 26784-26787 Protein denotes Akt
T17081 26643-26648 Protein denotes IL-17
T17080 26349-26369 Protein denotes CREB-binding protein
T17079 26344-26348 Protein denotes p300
T17078 26220-26232 Protein denotes IκB kinase-β
T17077 26035-26040 Protein denotes IL-17
T17076 25822-25827 Protein denotes IL-17
T17075 25810-25813 Protein denotes CD3
T17074 25768-25773 Protein denotes IL-17
T17073 25576-25581 Protein denotes IL-17
T17072 25497-25502 Protein denotes IL-17
T17071 25393-25398 Protein denotes IL-17
T17070 25373-25377 Protein denotes CD28
T17069 25139-25144 Protein denotes MCP-1
T17068 25080-25085 Protein denotes TNF-α
T17067 25050-25055 Protein denotes IL-17
T17066 25025-25030 Protein denotes IL-15
T17065 24956-24961 Protein denotes IL-17
T17064 24849-24854 Protein denotes TNF-α
T17063 24840-24844 Protein denotes IL-1
T17062 24795-24800 Protein denotes IL-17
T17061 24763-24768 Protein denotes MCP-1
T17060 24754-24759 Protein denotes IL-15
T17059 24729-24734 Protein denotes IL-17
T17058 24657-24662 Protein denotes MCP-1
T17057 24647-24652 Protein denotes IL-15
T17056 24611-24615 Protein denotes CD28
T17055 24471-24476 Protein denotes IL-17
T17054 24392-24397 Protein denotes IL-17
T17053 24357-24362 Protein denotes IL-23
T17052 24347-24352 Protein denotes IL-15
T17051 24298-24303 Protein denotes IL-17
T17050 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T17049 24135-24139 Protein denotes IL-8
T17048 24129-24133 Protein denotes IL-6
T17047 24051-24056 Protein denotes IL-17
T17046 23735-23740 Protein denotes IL-17
T17045 23652-23657 Protein denotes IL-23
T17044 23632-23635 Protein denotes CD8
T17043 23524-23527 Protein denotes CD4
T17042 23486-23491 Protein denotes IL-17
T17041 23397-23402 Protein denotes IL-17
T17040 23255-23260 Protein denotes IL-17
T17039 23197-23201 Protein denotes CD28
T17038 23155-23158 Protein denotes PHA
T17037 23089-23093 Protein denotes CD28
T17036 23039-23044 Protein denotes IL-17
T17035 22985-22990 Protein denotes IL-17
T17034 22835-22840 Protein denotes IL-17
T17033 22746-22751 Protein denotes IL-17
T17032 22594-22599 Protein denotes IL-17
T17031 22349-22361 Protein denotes interferon-γ
T17030 22340-22344 Protein denotes IL-4
T17029 22248-22253 Protein denotes TNF-α
T17028 22239-22243 Protein denotes IL-1
T17027 22004-22009 Protein denotes IL-17
T17138 24357-24362 Protein denotes IL-23
T17137 24347-24352 Protein denotes IL-15
T17136 24304-24314 Gene_expression denotes production
T17135 24298-24303 Protein denotes IL-17
T17134 24288-24297 Positive_regulation denotes stimulate
T17133 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T17132 24135-24139 Protein denotes IL-8
T17131 24129-24133 Protein denotes IL-6
T15581 21954-21963 Positive_regulation denotes activated
T15580 21940-21950 Gene_expression denotes production
T15579 21934-21939 Protein denotes IL-17
T15578 21839-21843 Protein denotes CD28
T15577 21769-21773 Protein denotes AP-1
T15576 21697-21702 Protein denotes IκB-α
T15575 21682-21693 Protein_catabolism denotes degradation
T15574 21668-21678 Negative_regulation denotes inhibition
T15573 21655-21660 Protein denotes IκB-α
T15572 21608-21613 Protein denotes IL-17
T15571 21584-21591 Binding denotes binding
T15570 21568-21573 Negative_regulation denotes block
T15569 21346-21350 Protein denotes CD28
T15568 21227-21232 Protein denotes c-Rel
T15567 21200-21203 Protein denotes p50
T15566 21192-21195 Protein denotes p65
T15565 21081-21086 Protein denotes IL-17
T15564 21061-21068 Binding denotes binding
T15563 21051-21060 Positive_regulation denotes increased
T15562 21024-21028 Protein denotes CD28
T15561 20931-20936 Protein denotes IL-17
T15560 20812-20822 Gene_expression denotes expression
T15559 20806-20811 Protein denotes IL-17
T15558 20797-20805 Negative_regulation denotes inducing
T15557 20770-20775 Protein denotes IL-15
T15556 20762-20765 Protein denotes PHA
T15555 20740-20744 Protein denotes CD28
T15554 20627-20632 Protein denotes IL-17
T15553 20606-20610 Protein denotes AP-1
T15552 20585-20604 Protein denotes activator protein-1
T15551 21934-21939 Protein denotes IL-17
T15550 21839-21843 Protein denotes CD28
T15549 21769-21773 Protein denotes AP-1
T15548 21697-21702 Protein denotes IκB-α
T15547 21655-21660 Protein denotes IκB-α
T15546 21608-21613 Protein denotes IL-17
T15545 21346-21350 Protein denotes CD28
T15544 21227-21232 Protein denotes c-Rel
T15543 21200-21203 Protein denotes p50
T15542 21192-21195 Protein denotes p65
T15541 21081-21086 Protein denotes IL-17
T15540 21024-21028 Protein denotes CD28
T15539 20931-20936 Protein denotes IL-17
T15538 20806-20811 Protein denotes IL-17
T15537 20770-20775 Protein denotes IL-15
T15536 20762-20765 Protein denotes PHA
T15535 20740-20744 Protein denotes CD28
T15534 20627-20632 Protein denotes IL-17
T15533 20606-20610 Protein denotes AP-1
T15532 20585-20604 Protein denotes activator protein-1
T14750 19786-19796 Gene_expression denotes production
T14749 19780-19785 Protein denotes IL-17
T14748 19745-19748 Protein denotes Akt
T14747 20440-20443 Protein denotes Akt
T14746 20382-20387 Protein denotes IL-15
T14745 20358-20361 Protein denotes PHA
T14744 20300-20307 Protein denotes β-actin
T14743 20292-20295 Protein denotes Akt
T14742 20136-20139 Protein denotes Akt
T14741 20066-20069 Protein denotes Akt
T14740 19904-19907 Protein denotes Akt
T14739 19780-19785 Protein denotes IL-17
T14738 19745-19748 Protein denotes Akt
T14436 19664-19673 Negative_regulation denotes inhibitor
T14766 20481-20491 Negative_regulation denotes inhibition
T14765 20440-20443 Protein denotes Akt
T14764 20425-20439 Phosphorylation denotes phosphorylated
T14763 20415-20421 Regulation denotes effect
T14762 20382-20387 Protein denotes IL-15
T14761 20358-20361 Protein denotes PHA
T14760 20300-20307 Protein denotes β-actin
T14759 20292-20295 Protein denotes Akt
T14758 20277-20291 Phosphorylation denotes phosphorylated
T14757 20140-20149 Positive_regulation denotes increased
T14756 20136-20139 Protein denotes Akt
T14755 20121-20135 Phosphorylation denotes phosphorylated
T14754 20066-20069 Protein denotes Akt
T14753 20051-20065 Phosphorylation denotes phosphorylated
T14752 19904-19907 Protein denotes Akt
T14751 19890-19900 Positive_regulation denotes activation
T14435 19642-19651 Negative_regulation denotes inhibited
T14434 19588-19599 Transcription denotes transcripts
T14433 19583-19587 Transcription denotes mRNA
T14432 19577-19582 Protein denotes IL-17
T14431 19565-19573 Positive_regulation denotes increase
T14430 19555-19564 Regulation denotes dependent
T14429 19417-19426 Regulation denotes regulated
T14428 19397-19407 Gene_expression denotes production
T14427 19391-19396 Protein denotes IL-17
T14426 19382-19390 Positive_regulation denotes enhanced
T14425 19340-19355 Transcription denotes mRNA expression
T14424 19334-19339 Protein denotes IL-17
T14423 19577-19582 Protein denotes IL-17
T14422 19391-19396 Protein denotes IL-17
T14421 19334-19339 Protein denotes IL-17
T13365 19080-19090 Gene_expression denotes production
T13364 19074-19079 Protein denotes IL-17
T13363 19059-19070 Negative_regulation denotes inhibitions
T13362 19049-19058 Regulation denotes dependent
T13361 19013-19023 Gene_expression denotes production
T13360 19007-19012 Protein denotes IL-17
T13359 18993-19003 Negative_regulation denotes inhibition
T13358 18820-18825 Protein denotes IL-17
T13357 18810-18816 Regulation denotes effect
T13356 18680-18689 Localization denotes secretion
T13355 18674-18679 Protein denotes IL-17
T13354 18656-18669 Negative_regulation denotes downregulated
T13353 18604-18615 Protein denotes calcineurin
T13352 18492-18502 Gene_expression denotes production
T13351 18486-18491 Protein denotes IL-17
T13350 18478-18485 Positive_regulation denotes induced
T13349 18455-18464 Negative_regulation denotes inhibited
T13348 18203-18213 Gene_expression denotes production
T13347 18197-18202 Protein denotes IL-17
T13346 18189-18196 Positive_regulation denotes induced
T13345 18168-18176 Negative_regulation denotes decrease
T13344 18029-18039 Gene_expression denotes production
T13343 18023-18028 Protein denotes IL-17
T13342 18013-18022 Positive_regulation denotes increased
T13341 17923-17933 Gene_expression denotes production
T13340 17917-17922 Protein denotes IL-17
T13339 17903-17913 Negative_regulation denotes Inhibition
T13338 19074-19079 Protein denotes IL-17
T13337 19007-19012 Protein denotes IL-17
T13336 18820-18825 Protein denotes IL-17
T13335 18674-18679 Protein denotes IL-17
T13334 18604-18615 Protein denotes calcineurin
T13333 18486-18491 Protein denotes IL-17
T13332 18197-18202 Protein denotes IL-17
T13331 18023-18028 Protein denotes IL-17
T13330 17917-17922 Protein denotes IL-17
T12445 17873-17879 Protein denotes MIP-1β
T12444 17852-17858 Protein denotes MIP-1α
T12443 17835-17839 Protein denotes IL-8
T12442 17707-17712 Protein denotes IL-17
T12441 17661-17665 Protein denotes IL-6
T12440 17641-17646 Protein denotes MCP-1
T12439 17591-17596 Protein denotes IL-17
T12438 17560-17565 Protein denotes TGF-β
T12437 17540-17545 Protein denotes IL-18
T12436 17522-17527 Protein denotes TNF-α
T12435 17504-17509 Protein denotes IL-1β
T12434 17473-17478 Protein denotes IL-15
T12433 17438-17443 Protein denotes IL-17
T12432 17426-17434 Positive_regulation denotes increase
T12431 17399-17409 Gene_expression denotes production
T12430 17393-17398 Protein denotes IL-17
T12429 17234-17239 Protein denotes IL-17
T12428 17220-17230 Gene_expression denotes production
T12427 17207-17215 Regulation denotes affected
T12426 16990-17000 Gene_expression denotes production
T11677 16921-16925 Protein denotes CD28
T11676 16862-16872 Gene_expression denotes production
T11675 16856-16861 Protein denotes IL-17
T11674 16846-16855 Positive_regulation denotes increased
T11673 16841-16844 Protein denotes PHA
T11672 16728-16733 Protein denotes IL-17
T11671 16714-16722 Gene_expression denotes produced
T11670 16696-16700 Protein denotes CD28
T11669 16641-16651 Gene_expression denotes production
T11668 16635-16640 Protein denotes IL-17
T11667 16623-16634 Positive_regulation denotes upregulated
T11666 16463-16468 Protein denotes IL-17
T11665 16451-16459 Positive_regulation denotes increase
T11664 16441-16450 Regulation denotes dependent
T11663 16272-16280 Gene_expression denotes produced
T11662 16221-16226 Protein denotes IL-17
T11661 16209-16212 Protein denotes PHA
T11660 16199-16203 Protein denotes CD28
T11659 16136-16146 Gene_expression denotes production
T11658 16130-16135 Protein denotes IL-17
T11657 16120-16129 Positive_regulation denotes Increased
T11656 16921-16925 Protein denotes CD28
T11655 16856-16861 Protein denotes IL-17
T11654 16841-16844 Protein denotes PHA
T11653 16728-16733 Protein denotes IL-17
T11652 16696-16700 Protein denotes CD28
T11651 16635-16640 Protein denotes IL-17
T11650 16463-16468 Protein denotes IL-17
T11649 16221-16226 Protein denotes IL-17
T11648 16209-16212 Protein denotes PHA
T11647 16199-16203 Protein denotes CD28
T11646 16130-16135 Protein denotes IL-17
T12425 16984-16989 Protein denotes IL-17
T12424 16970-16980 Regulation denotes Regulation
T12423 17873-17879 Protein denotes MIP-1β
T12422 17852-17858 Protein denotes MIP-1α
T12421 17835-17839 Protein denotes IL-8
T12420 17707-17712 Protein denotes IL-17
T12419 17661-17665 Protein denotes IL-6
T12418 17641-17646 Protein denotes MCP-1
T12417 17591-17596 Protein denotes IL-17
T12416 17560-17565 Protein denotes TGF-β
T12415 17540-17545 Protein denotes IL-18
T12414 17522-17527 Protein denotes TNF-α
T12413 17504-17509 Protein denotes IL-1β
T12412 17473-17478 Protein denotes IL-15
T12411 17438-17443 Protein denotes IL-17
T12410 17393-17398 Protein denotes IL-17
T12409 17234-17239 Protein denotes IL-17
T12408 16984-16989 Protein denotes IL-17
T11111 15988-15994 Positive_regulation denotes higher
T11110 15966-15969 Protein denotes PHA
T11109 15952-15962 Positive_regulation denotes stimulated
T11108 15941-15951 Gene_expression denotes production
T11107 15935-15940 Protein denotes IL-17
T11106 15815-15824 Localization denotes secretion
T11105 15809-15814 Protein denotes IL-17
T11104 15707-15712 Protein denotes IL-17
T11103 15619-15622 Protein denotes PHA
T11102 15499-15509 Gene_expression denotes production
T11101 15493-15498 Protein denotes IL-17
T11100 15966-15969 Protein denotes PHA
T11099 15935-15940 Protein denotes IL-17
T11098 15809-15814 Protein denotes IL-17
T11097 15707-15712 Protein denotes IL-17
T11096 15619-15622 Protein denotes PHA
T11095 15493-15498 Protein denotes IL-17
T9989 14837-14842 Protein denotes c-Rel
T9988 14829-14832 Protein denotes p65
T9987 14824-14827 Protein denotes p50
T9986 13930-13935 Protein denotes IL-17
T9985 14837-14842 Protein denotes c-Rel
T9984 14829-14832 Protein denotes p65
T9983 14824-14827 Protein denotes p50
T9982 13930-13935 Protein denotes IL-17
T9217 13304-13309 Protein denotes IκB-α
T9216 13296-13299 Protein denotes Akt
T9215 13281-13295 Phosphorylation denotes phosphorylated
T9214 13276-13279 Protein denotes Akt
T9213 12541-12544 Protein denotes Akt
T9212 12526-12540 Phosphorylation denotes phosphorylated
T9211 12521-12524 Protein denotes Akt
T9210 13304-13309 Protein denotes IκB-α
T9209 13296-13299 Protein denotes Akt
T9208 13276-13279 Protein denotes Akt
T9207 12549-12554 Protein denotes IκB-α
T9206 12541-12544 Protein denotes Akt
T9205 12521-12524 Protein denotes Akt
T8218 12480-12485 Protein denotes GAPDH
T8217 12457-12462 Protein denotes IL-17
T8216 12413-12428 Transcription denotes mRNA expression
T8215 12297-12302 Protein denotes IL-17
T8214 12287-12292 Protein denotes GAPDH
T8213 12186-12191 Protein denotes IL-17
T8212 12176-12181 Protein denotes GAPDH
T8211 11957-11962 Protein denotes GAPDH
T8210 11910-11915 Protein denotes GAPDH
T8209 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8208 11760-11765 Protein denotes IL-17
T8207 11497-11500 Protein denotes Taq
T8206 10920-10925 Protein denotes IL-17
T8205 12480-12485 Protein denotes GAPDH
T8204 12457-12462 Protein denotes IL-17
T8203 12297-12302 Protein denotes IL-17
T8202 12287-12292 Protein denotes GAPDH
T8201 12186-12191 Protein denotes IL-17
T8200 12176-12181 Protein denotes GAPDH
T8199 11957-11962 Protein denotes GAPDH
T8198 11910-11915 Protein denotes GAPDH
T8197 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8196 11760-11765 Protein denotes IL-17
T8195 11497-11500 Protein denotes Taq
T8194 10920-10925 Protein denotes IL-17
T7259 10878-10883 Protein denotes IL-17
T7258 10631-10636 Protein denotes IL-17
T7257 10583-10588 Protein denotes IL-17
T7256 10140-10145 Protein denotes IL-17
T7255 9885-9890 Protein denotes IL-17
T7254 9669-9674 Protein denotes IL-17
T7253 9463-9468 Protein denotes IL-17
T7252 10878-10883 Protein denotes IL-17
T7251 10631-10636 Protein denotes IL-17
T7250 10583-10588 Protein denotes IL-17
T7249 10140-10145 Protein denotes IL-17
T7248 9885-9890 Protein denotes IL-17
T7247 9669-9674 Protein denotes IL-17
T7246 9463-9468 Protein denotes IL-17
T7245 9457-9462 Protein denotes IL-17
T6538 9400-9403 Protein denotes CD4
T6537 9052-9055 Protein denotes CD4
T6536 8506-8509 Protein denotes CD4
T6535 8357-8360 Protein denotes CD4
T6534 8322-8325 Protein denotes CD4
T6533 9400-9403 Protein denotes CD4
T6532 9052-9055 Protein denotes CD4
T6531 8506-8509 Protein denotes CD4
T6530 8357-8360 Protein denotes CD4
T6529 8322-8325 Protein denotes CD4
T5915 7305-7310 Protein denotes IL-17
T5914 7291-7301 Gene_expression denotes Production
T5913 7305-7310 Protein denotes IL-17
T5268 7106-7110 Protein denotes CD28
T5267 6921-6924 Protein denotes PHA
T5266 6901-6919 Protein denotes Phytohemagglutinin
T5261 6593-6597 Protein denotes IL-6
T5260 6585-6591 Protein denotes MIP-1β
T5259 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5258 6535-6540 Protein denotes MCP-1
T5257 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5256 6492-6497 Protein denotes IL-15
T5255 6485-6490 Protein denotes IL-18
T5254 6478-6483 Protein denotes IL-17
T5253 7106-7110 Protein denotes CD28
T5252 6921-6924 Protein denotes PHA
T5251 6901-6919 Protein denotes Phytohemagglutinin
T5250 6777-6781 Protein denotes IL-1
T5249 6767-6772 Protein denotes TNF-α
T5248 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5247 6602-6606 Protein denotes IL-8
T5246 6593-6597 Protein denotes IL-6
T5245 6585-6591 Protein denotes MIP-1β
T5244 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5243 6535-6540 Protein denotes MCP-1
T5242 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5241 6492-6497 Protein denotes IL-15
T5240 6485-6490 Protein denotes IL-18
T5239 6478-6483 Protein denotes IL-17
T5265 6777-6781 Protein denotes IL-1
T5264 6767-6772 Protein denotes TNF-α
T5263 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5262 6602-6606 Protein denotes IL-8
T2227 5145-5150 Protein denotes IL-17
T2226 5010-5015 Protein denotes IL-17
T2225 4962-4965 Protein denotes CD8
T2224 4953-4956 Protein denotes CD4
T2223 4932-4942 Gene_expression denotes production
T2222 4926-4931 Protein denotes IL-17
T2221 4915-4922 Positive_regulation denotes trigger
T2220 4887-4892 Protein denotes IL-23
T2219 4726-4736 Gene_expression denotes production
T2218 4720-4725 Protein denotes IL-17
T2217 4709-4716 Positive_regulation denotes trigger
T2216 4628-4633 Protein denotes IL-15
T2215 4590-4593 Protein denotes CD4
T2214 4578-4586 Gene_expression denotes produced
T2213 4453-4458 Protein denotes IL-17
T2212 4263-4289 Protein denotes leukemia inhibitory factor
T2211 4254-4258 Protein denotes IL-6
T2210 4240-4250 Gene_expression denotes production
T2209 4225-4235 Positive_regulation denotes stimulates
T2208 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2207 4108-4113 Protein denotes RANKL
T2206 4095-4104 Positive_regulation denotes induction
T2205 4035-4040 Protein denotes IL-17
T2204 3972-3980 Gene_expression denotes produced
T2203 3920-3925 Protein denotes IL-17
T2202 3914-3918 Protein denotes IL-1
T2201 3904-3909 Protein denotes TNF-α
T2200 3807-3811 Protein denotes IL-8
T2199 3798-3802 Protein denotes IL-6
T2198 3791-3797 Positive_regulation denotes induce
T2197 3700-3705 Protein denotes IL-17
T2196 3325-3330 Protein denotes TNF-α
T2195 3315-3320 Protein denotes IL-18
T2194 3308-3313 Protein denotes IL-15
T2193 3302-3306 Protein denotes IL-6
T2192 3296-3300 Protein denotes IL-1
T2191 3208-3220 Protein denotes interferon-γ
T2190 3199-3203 Protein denotes IL-2
T2189 2762-2780 Protein denotes interleukin (IL)-1
T2188 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T2187 2713-2723 Negative_regulation denotes inhibitors
T2186 5506-5511 Protein denotes IL-17
T2185 5419-5422 Protein denotes Akt
T2184 5241-5246 Protein denotes IL-17
T2183 5145-5150 Protein denotes IL-17
T2182 5010-5015 Protein denotes IL-17
T2181 4962-4965 Protein denotes CD8
T2180 4953-4956 Protein denotes CD4
T2179 4926-4931 Protein denotes IL-17
T2178 4887-4892 Protein denotes IL-23
T2177 4720-4725 Protein denotes IL-17
T2176 4628-4633 Protein denotes IL-15
T2175 4590-4593 Protein denotes CD4
T2174 4453-4458 Protein denotes IL-17
T2173 4263-4289 Protein denotes leukemia inhibitory factor
T2172 4254-4258 Protein denotes IL-6
T2171 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2170 4108-4113 Protein denotes RANKL
T2169 4035-4040 Protein denotes IL-17
T2168 3920-3925 Protein denotes IL-17
T2167 3914-3918 Protein denotes IL-1
T2166 3904-3909 Protein denotes TNF-α
T2165 3807-3811 Protein denotes IL-8
T2164 3798-3802 Protein denotes IL-6
T2163 3700-3705 Protein denotes IL-17
T2162 3325-3330 Protein denotes TNF-α
T2161 3315-3320 Protein denotes IL-18
T2160 3308-3313 Protein denotes IL-15
T2159 3302-3306 Protein denotes IL-6
T2158 3296-3300 Protein denotes IL-1
T2157 3208-3220 Protein denotes interferon-γ
T2156 3199-3203 Protein denotes IL-2
T2155 2762-2780 Protein denotes interleukin (IL)-1
T2154 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T2232 5506-5511 Protein denotes IL-17
T2231 5419-5422 Protein denotes Akt
T2230 5247-5257 Gene_expression denotes production
T2229 5241-5246 Protein denotes IL-17
T2228 5151-5161 Gene_expression denotes production
T183 2393-2398 Protein denotes IL-17
T182 2311-2314 Protein denotes Akt
T181 2225-2235 Gene_expression denotes production
T180 2219-2224 Protein denotes IL-17
T179 2212-2218 Regulation denotes affect
T178 2202-2203 Protein denotes 2
T177 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T176 2138-2157 Protein denotes activator protein-1
T175 2124-2134 Negative_regulation denotes inhibition
T174 2066-2075 Negative_regulation denotes inhibitor
T173 2062-2065 Protein denotes Akt
T172 1932-1941 Positive_regulation denotes activated
T171 1918-1928 Gene_expression denotes production
T170 1912-1917 Protein denotes IL-17
T169 1894-1901 Binding denotes binding
T168 1823-1831 Positive_regulation denotes resulted
T167 1783-1786 Protein denotes Akt
T166 1689-1699 Gene_expression denotes expression
T165 1610-1615 Protein denotes IL-17
T164 1572-1600 Protein denotes transforming growth factor-β
T163 1563-1568 Protein denotes IL-18
T162 1556-1561 Protein denotes IL-1β
T161 1531-1554 Protein denotes tumor necrosis factor-α
T160 1500-1510 Gene_expression denotes production
T159 1494-1499 Protein denotes IL-17
T158 1482-1493 Positive_regulation denotes upregulated
T157 1477-1481 Protein denotes IL-6
T156 1438-1472 Protein denotes monocyte chemoattractant protein-1
T155 1431-1436 Protein denotes IL-15
T154 1376-1379 Protein denotes PHA
T153 1367-1371 Protein denotes CD28
T152 1296-1305 Positive_regulation denotes increased
T151 1272-1277 Protein denotes IL-17
T150 1258-1268 Gene_expression denotes production
T149 1126-1131 Protein denotes IL-17
T148 1070-1073 Protein denotes PHA
T147 1050-1068 Protein denotes phytohemagglutinin
T146 1044-1048 Protein denotes CD28
T145 876-886 Gene_expression denotes production
T144 870-875 Protein denotes IL-17
T143 856-866 Regulation denotes regulation
T142 837-840 Protein denotes Akt
T141 723-733 Gene_expression denotes production
T140 717-722 Protein denotes IL-17
T139 708-716 Regulation denotes regulate
T138 654-664 Gene_expression denotes production
T137 648-653 Protein denotes IL-17
T136 639-647 Regulation denotes regulate
T135 610-615 Protein denotes IL-23
T134 600-605 Protein denotes IL-15
T133 504-509 Protein denotes IL-17
T132 273-292 Protein denotes Interleukin (IL)-17
T127 2393-2398 Protein denotes IL-17
T126 2311-2314 Protein denotes Akt
T125 2219-2224 Protein denotes IL-17
T124 2202-2203 Protein denotes 2
T123 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T122 2138-2157 Protein denotes activator protein-1
T121 2062-2065 Protein denotes Akt
T120 1912-1917 Protein denotes IL-17
T119 1783-1786 Protein denotes Akt
T118 1610-1615 Protein denotes IL-17
T117 1572-1600 Protein denotes transforming growth factor-β
T116 1563-1568 Protein denotes IL-18
T115 1556-1561 Protein denotes IL-1β
T114 1531-1554 Protein denotes tumor necrosis factor-α
T113 1494-1499 Protein denotes IL-17
T112 1477-1481 Protein denotes IL-6
T111 1438-1472 Protein denotes monocyte chemoattractant protein-1
T110 1431-1436 Protein denotes IL-15
T109 1376-1379 Protein denotes PHA
T108 1367-1371 Protein denotes CD28
T107 1272-1277 Protein denotes IL-17
T106 1126-1131 Protein denotes IL-17
T105 1070-1073 Protein denotes PHA
T104 1050-1068 Protein denotes phytohemagglutinin
T103 1044-1048 Protein denotes CD28
T102 870-875 Protein denotes IL-17
T101 837-840 Protein denotes Akt
T100 717-722 Protein denotes IL-17
T99 648-653 Protein denotes IL-17
T98 610-615 Protein denotes IL-23
T97 600-605 Protein denotes IL-15
T96 504-509 Protein denotes IL-17
T95 273-292 Protein denotes Interleukin (IL)-17
R30 T129 T130 themeOf interleukin-17,production
R31 T130 T128 themeOf production,Increased
R32 T131 T128 causeOf Akt,Increased
R33 T135 T136 causeOf IL-23,regulate
R34 T137 T138 themeOf IL-17,production
R35 T138 T136 themeOf production,regulate
R36 T140 T141 themeOf IL-17,production
R37 T141 T139 themeOf production,regulate
R38 T144 T145 themeOf IL-17,production
R39 T145 T143 themeOf production,regulation
R40 T148 T147 equivalentTo PHA,phytohemagglutinin
R41 T150 T152 themeOf production,increased
R42 T151 T150 themeOf IL-17,production
R43 T154 T152 causeOf PHA,increased
R44 T155 T158 causeOf IL-15,upregulated
R45 T156 T158 causeOf monocyte chemoattractant protein-1,upregulated
R46 T156 T160 themeOf monocyte chemoattractant protein-1,production
R47 T157 T158 causeOf IL-6,upregulated
R48 T159 T160 themeOf IL-17,production
R49 T160 T158 themeOf production,upregulated
R50 T165 T166 themeOf IL-17,expression
R51 T170 T171 themeOf IL-17,production
R52 T173 T174 themeOf Akt,inhibitor
R53 T175 T179 causeOf inhibition,affect
R54 T176 T175 themeOf activator protein-1,inhibition
R55 T177 T179 causeOf extracellular signal-regulated kinase 1,affect
R56 T177 T175 themeOf extracellular signal-regulated kinase 1,inhibition
R57 T178 T175 themeOf 2,inhibition
R58 T180 T181 themeOf IL-17,production
R59 T181 T179 themeOf production,affect
R1090 T2188 T2187 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1091 T2189 T2187 themeOf interleukin (IL)-1,inhibitors
R1092 T2197 T2198 causeOf IL-17,induce
R1093 T2199 T2198 themeOf IL-6,induce
R1094 T2200 T2198 themeOf IL-8,induce
R1095 T2201 T2204 themeOf TNF-α,produced
R1096 T2202 T2204 themeOf IL-1,produced
R1097 T2203 T2204 themeOf IL-17,produced
R1098 T2207 T2206 themeOf RANKL,induction
R1099 T2208 T2207 equivalentTo receptor activator of nuclear factor κB [NF-κB] ligand,RANKL
R1100 T2210 T2209 themeOf production,stimulates
R1101 T2211 T2210 themeOf IL-6,production
R1102 T2213 T2214 themeOf IL-17,produced
R1103 T2218 T2219 themeOf IL-17,production
R1104 T2219 T2217 themeOf production,trigger
R1105 T2220 T2221 causeOf IL-23,trigger
R1106 T2222 T2223 themeOf IL-17,production
R1107 T2223 T2221 themeOf production,trigger
R1108 T2227 T2228 themeOf IL-17,production
R1109 T2229 T2230 themeOf IL-17,production
R2808 T5258 T5257 equivalentTo MCP-1,monocyte chemoattractant protein-1
R2809 T5267 T5266 equivalentTo PHA,Phytohemagglutinin
R3142 T5915 T5914 themeOf IL-17,Production
R4473 T8210 T8209 equivalentTo GAPDH,glyceraldehyde-3-phosphate dehydrogenase
R4474 T8217 T8216 themeOf IL-17,mRNA expression
R4475 T8218 T8216 themeOf GAPDH,mRNA expression
R4826 T9207 T9212 themeOf IκB-α,phosphorylated
R4827 T9213 T9212 themeOf Akt,phosphorylated
R4828 T9216 T9215 themeOf Akt,phosphorylated
R4829 T9217 T9215 themeOf IκB-α,phosphorylated
R5994 T11101 T11102 themeOf IL-17,production
R5995 T11105 T11106 themeOf IL-17,secretion
R5996 T11107 T11108 themeOf IL-17,production
R5997 T11108 T11109 themeOf production,stimulated
R5998 T11108 T11111 themeOf production,higher
R5999 T11109 T11111 themeOf stimulated,higher
R6000 T11110 T11109 causeOf PHA,stimulated
R6317 T11658 T11659 themeOf IL-17,production
R6318 T11659 T11657 themeOf production,Increased
R6319 T11661 T11657 causeOf PHA,Increased
R6320 T11662 T11663 themeOf IL-17,produced
R6321 T11666 T11665 themeOf IL-17,increase
R6322 T11668 T11669 themeOf IL-17,production
R6323 T11669 T11667 themeOf production,upregulated
R6324 T11672 T11671 themeOf IL-17,produced
R6325 T11675 T11676 themeOf IL-17,production
R6326 T11676 T11674 themeOf production,increased
R6750 T12425 T12426 themeOf IL-17,production
R6751 T12426 T12424 themeOf production,Regulation
R6752 T12428 T12427 themeOf production,affected
R6753 T12429 T12428 themeOf IL-17,production
R6754 T12430 T12431 themeOf IL-17,production
R6755 T12433 T12432 themeOf IL-17,increase
R6756 T12434 T12432 causeOf IL-15,increase
R6757 T12435 T12432 causeOf IL-1β,increase
R6758 T12436 T12432 causeOf TNF-α,increase
R6759 T12438 T12432 causeOf TGF-β,increase
R6760 T12439 T12432 causeOf IL-17,increase
R7271 T13340 T13341 themeOf IL-17,production
R7272 T13341 T13339 themeOf production,Inhibition
R7273 T13343 T13344 themeOf IL-17,production
R7274 T13344 T13342 themeOf production,increased
R7275 T13346 T13345 themeOf induced,decrease
R7276 T13347 T13348 themeOf IL-17,production
R7277 T13348 T13346 themeOf production,induced
R7278 T13350 T13349 themeOf induced,inhibited
R7279 T13351 T13352 themeOf IL-17,production
R7280 T13352 T13350 themeOf production,induced
R7281 T13353 T13354 causeOf calcineurin,downregulated
R7282 T13355 T13356 themeOf IL-17,secretion
R7283 T13356 T13354 themeOf secretion,downregulated
R7284 T13360 T13361 themeOf IL-17,production
R7285 T13361 T13359 themeOf production,inhibition
R7286 T13364 T13365 themeOf IL-17,production
R7287 T13365 T13363 themeOf production,inhibitions
R7965 T14424 T14425 themeOf IL-17,mRNA expression
R7966 T14426 T14429 themeOf enhanced,regulated
R7967 T14427 T14428 themeOf IL-17,production
R7968 T14428 T14429 themeOf production,regulated
R7969 T14428 T14426 themeOf production,enhanced
R7970 T14433 T14431 themeOf mRNA,increase
R7971 T14434 T14431 themeOf transcripts,increase
R7972 T14436 T14435 causeOf inhibitor,inhibited
R8142 T14749 T14750 themeOf IL-17,production
R8143 T14752 T14751 themeOf Akt,activation
R8144 T14754 T14753 themeOf Akt,phosphorylated
R8145 T14756 T14755 themeOf Akt,phosphorylated
R8146 T14759 T14758 themeOf Akt,phosphorylated
R8147 T14761 T14763 causeOf PHA,effect
R8148 T14762 T14763 causeOf IL-15,effect
R8149 T14764 T14763 themeOf phosphorylated,effect
R8150 T14765 T14764 themeOf Akt,phosphorylated
R8554 T15553 T15552 equivalentTo AP-1,activator protein-1
R8555 T15556 T15558 causeOf PHA,inducing
R8556 T15559 T15560 themeOf IL-17,expression
R8557 T15560 T15558 themeOf expression,inducing
R8558 T15564 T15563 themeOf binding,increased
R8559 T15571 T15570 themeOf binding,block
R8560 T15575 T15574 themeOf degradation,inhibition
R8561 T15576 T15574 themeOf IκB-α,inhibition
R8562 T15576 T15575 themeOf IκB-α,degradation
R8563 T15579 T15580 themeOf IL-17,production
R9267 T17102 T17103 themeOf IL-17,production
R9268 T17103 T17104 themeOf production,regulated
R9269 T17107 T17108 themeOf IL-17,production
R9270 T17108 T17106 themeOf production,stimulate
R9271 T17109 T17110 themeOf IL-17,production
R9272 T17110 T17106 themeOf production,stimulate
R9273 T17112 T17114 causeOf PHA,increased
R9274 T17114 T17117 themeOf increased,dependent
R9275 T17115 T17116 themeOf IL-17,production
R9276 T17116 T17114 themeOf production,increased
R9277 T17116 T17117 themeOf production,dependent
R9278 T17118 T17120 themeOf upregulation,due
R9279 T17119 T17118 themeOf IL-17,upregulation
R9280 T17121 T17122 themeOf IL-17,produced
R9281 T17127 T17128 themeOf IL-17,production
R9282 T17128 T17129 themeOf production,augmented
R9283 T17135 T17136 themeOf IL-17,production
R9284 T17136 T17134 themeOf production,stimulate
R9285 T17138 T17134 causeOf IL-23,stimulate
R9286 T17140 T17141 themeOf IL-17,production
R9287 T17141 T17139 themeOf production,regulate
R9288 T17143 T17142 themeOf IL-17,production
R9289 T17148 T17147 themeOf production,increased
R9290 T17149 T17148 themeOf IL-17,production
R9291 T17153 T17154 themeOf IL-17,production
R9292 T17154 T17152 themeOf production,augmented
R9293 T17155 T17158 causeOf IL-1,affect
R9294 T17159 T17160 themeOf IL-17,production
R9295 T17160 T17158 themeOf production,affect
R9296 T17161 T17162 causeOf IL-15,triggered
R9297 T17163 T17164 themeOf IL-17,production
R9298 T17164 T17162 themeOf production,triggered
R9299 T17169 T17170 themeOf IL-17,induction
R9300 T17170 T17168 themeOf induction,increases
R9301 T17172 T17173 themeOf IL-17,production
R9302 T17173 T17174 themeOf production,regulated
R9303 T17176 T17175 themeOf induction,involved
R9304 T17177 T17176 themeOf IL-17,induction
R9305 T17178 T17179 causeOf CD3,induced
R9306 T17179 T17182 themeOf induced,hampered
R9307 T17180 T17181 themeOf IL-17,production
R9308 T17181 T17182 themeOf production,hampered
R9309 T17181 T17179 themeOf production,induced
R9310 T17183 T17186 themeOf induced,downregulated
R9311 T17184 T17185 themeOf IL-17,production
R9312 T17185 T17186 themeOf production,downregulated
R9313 T17185 T17183 themeOf production,induced
R9314 T17187 T17186 causeOf inhibitor,downregulated
R9315 T17188 T17189 themeOf IκB kinase-β,activated
R9316 T17192 T17193 themeOf binding,decreased
R9317 T17194 T17195 themeOf IL-17,production
R9318 T17196 T17197 themeOf Akt,activation
R9319 T17199 T17200 themeOf Akt,phosphorylated
R9320 T17202 T17201 themeOf IL-17,induction
R9321 T17207 T17206 themeOf IL-17,induction
R9322 T17209 T17210 themeOf Akt,association
R9323 T17212 T17213 themeOf IL-17,lacking
R9324 T17216 T17215 themeOf IL-17,upregulation
R9325 T17219 T17218 partOf promoter,IL-17
R9326 T17219 T17217 themeOf promoter,binding
R12065 T22080 T22079 themeOf IL-17,production
R12066 T22085 T22084 themeOf IL-17,upregulation
R12067 T22088 T22089 themeOf IL-17,production
R12068 T22089 T22087 themeOf production,regulation

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T1281 10-24 Protein denotes interleukin-17
T1282 68-71 Protein denotes Akt
T1316 25-35 Gene_expression denotes production
T1317 0-9 Positive_regulation denotes Increased
T16333 21934-21939 Protein denotes IL-17
T22407 28286-28291 Protein denotes IL-17
T22406 28240-28244 Protein denotes CD28
T22405 28194-28199 Protein denotes MCP-1
T22404 28184-28189 Protein denotes IL-15
T22403 28150-28155 Protein denotes IL-17
T22415 28483-28493 Regulation denotes regulation
T22414 28503-28513 Gene_expression denotes production
T22413 28270-28282 Positive_regulation denotes upregulation
T22412 28136-28146 Gene_expression denotes production
T22411 28172-28180 Positive_regulation denotes response
T22410 28675-28680 Protein denotes IL-17
T22409 28497-28502 Protein denotes IL-17
T22408 28380-28383 Protein denotes Akt
T20163 27897-27906 Positive_regulation denotes induction
T20162 27678-27690 Positive_regulation denotes upregulation
T20161 27420-27431 Binding denotes association
T20160 27554-27561 Negative_regulation denotes lacking
T20159 27174-27183 Positive_regulation denotes induction
T20158 27158-27166 Regulation denotes involved
T20157 26873-26887 Phosphorylation denotes phosphorylated
T20156 26963-26972 Positive_regulation denotes induction
T20155 26936-26947 Regulation denotes involvement
T20154 26788-26798 Positive_regulation denotes activation
T20153 26772-26780 Regulation denotes response
T20152 26649-26659 Gene_expression denotes production
T20151 26316-26325 Positive_regulation denotes involving
T20150 26236-26245 Positive_regulation denotes activated
T20149 26018-26034 Positive_regulation denotes anti-CD3-induced
T20148 26041-26051 Gene_expression denotes production
T20147 26056-26069 Negative_regulation denotes downregulated
T20146 25814-25821 Positive_regulation denotes induced
T20145 25828-25838 Gene_expression denotes production
T20144 25868-25876 Negative_regulation denotes hampered
T20143 25755-25764 Positive_regulation denotes induction
T20142 25739-25747 Regulation denotes involved
T20132 24917-24926 Positive_regulation denotes increased
T20131 24785-24794 Positive_regulation denotes augmented
T20130 24747-24753 Positive_regulation denotes Adding
T20129 24801-24811 Gene_expression denotes production
T20128 24701-24710 Positive_regulation denotes increased
T20127 24678-24686 Binding denotes ligation
T20126 24715-24725 Gene_expression denotes production
T20125 24457-24467 Gene_expression denotes production
T20124 24383-24391 Regulation denotes regulate
T20123 24288-24297 Positive_regulation denotes stimulate
T20122 24304-24314 Gene_expression denotes production
T20121 24398-24408 Gene_expression denotes production
T20120 24095-24102 Localization denotes secrete
T20119 23770-23779 Positive_regulation denotes augmented
T20118 23741-23751 Gene_expression denotes production
T20117 23495-23503 Gene_expression denotes produced
T20116 23381-23393 Positive_regulation denotes upregulation
T20115 23245-23254 Positive_regulation denotes increased
T20114 23261-23271 Gene_expression denotes production
T20113 23045-23055 Gene_expression denotes production
T20112 22975-22984 Positive_regulation denotes stimulate
T20111 22991-23001 Gene_expression denotes production
T20110 22766-22775 Regulation denotes regulated
T20109 22752-22762 Gene_expression denotes production
T20108 27996-28001 Protein denotes IL-17
T20107 27915-27920 Protein denotes IL-17
T20106 27802-27807 Protein denotes IL-17
T20105 27694-27699 Protein denotes IL-17
T20104 27603-27606 Protein denotes Akt
T20103 27544-27549 Protein denotes IL-17
T20102 27413-27416 Protein denotes Akt
T20101 27222-27226 Protein denotes AP-1
T20100 27187-27192 Protein denotes IL-17
T20099 27062-27067 Protein denotes IL-15
T20098 27056-27060 Protein denotes CD28
T20097 26976-26981 Protein denotes IL-17
T20096 26866-26869 Protein denotes Akt
T20095 26784-26787 Protein denotes Akt
T20094 26643-26648 Protein denotes IL-17
T20093 26349-26369 Protein denotes CREB-binding protein
T20092 26344-26348 Protein denotes p300
T20091 26220-26232 Protein denotes IκB kinase-β
T20090 26035-26040 Protein denotes IL-17
T20089 25822-25827 Protein denotes IL-17
T20088 25810-25813 Protein denotes CD3
T20087 25768-25773 Protein denotes IL-17
T20086 25576-25581 Protein denotes IL-17
T20085 25497-25502 Protein denotes IL-17
T20084 25393-25398 Protein denotes IL-17
T20083 25373-25377 Protein denotes CD28
T20082 25139-25144 Protein denotes MCP-1
T20081 25080-25085 Protein denotes TNF-α
T20080 25050-25055 Protein denotes IL-17
T20079 25025-25030 Protein denotes IL-15
T20078 24956-24961 Protein denotes IL-17
T20077 24849-24854 Protein denotes TNF-α
T20076 24840-24844 Protein denotes IL-1
T20075 24795-24800 Protein denotes IL-17
T20074 24763-24768 Protein denotes MCP-1
T20073 24754-24759 Protein denotes IL-15
T20072 24729-24734 Protein denotes IL-17
T20071 24657-24662 Protein denotes MCP-1
T20070 24647-24652 Protein denotes IL-15
T20069 24611-24615 Protein denotes CD28
T20068 24471-24476 Protein denotes IL-17
T20067 24392-24397 Protein denotes IL-17
T20066 24357-24362 Protein denotes IL-23
T20065 24347-24352 Protein denotes IL-15
T20064 24298-24303 Protein denotes IL-17
T20063 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T20062 24135-24139 Protein denotes IL-8
T20061 24129-24133 Protein denotes IL-6
T20060 24051-24056 Protein denotes IL-17
T20059 23735-23740 Protein denotes IL-17
T20058 23652-23657 Protein denotes IL-23
T20057 23632-23635 Protein denotes CD8
T20056 23524-23527 Protein denotes CD4
T20055 23486-23491 Protein denotes IL-17
T20054 23397-23402 Protein denotes IL-17
T20053 23255-23260 Protein denotes IL-17
T20052 23197-23201 Protein denotes CD28
T20051 23155-23158 Protein denotes PHA
T20050 22985-22990 Protein denotes IL-17
T20049 23089-23093 Protein denotes CD28
T20048 23039-23044 Protein denotes IL-17
T20047 22835-22840 Protein denotes IL-17
T20046 22746-22751 Protein denotes IL-17
T20045 22594-22599 Protein denotes IL-17
T20044 22349-22361 Protein denotes interferon-γ
T20043 22340-22344 Protein denotes IL-4
T20042 22248-22253 Protein denotes TNF-α
T20041 22239-22243 Protein denotes IL-1
T20040 22004-22009 Protein denotes IL-17
T20141 25600-25609 Regulation denotes regulated
T20140 25582-25592 Gene_expression denotes production
T20139 25383-25392 Positive_regulation denotes increases
T20138 25399-25408 Positive_regulation denotes induction
T20137 25154-25161 Positive_regulation denotes induces
T20136 25056-25066 Gene_expression denotes production
T20135 25031-25040 Positive_regulation denotes triggered
T20134 24949-24955 Regulation denotes affect
T20133 24962-24972 Gene_expression denotes production
T16342 21940-21950 Gene_expression denotes production
T16341 21668-21678 Negative_regulation denotes inhibition
T16340 21682-21693 Protein_catabolism denotes degradation
T16339 21061-21068 Binding denotes binding
T16338 21051-21060 Positive_regulation denotes increased
T16337 20797-20805 Positive_regulation denotes inducing
T16336 20708-20717 Positive_regulation denotes activated
T16335 20812-20822 Gene_expression denotes expression
T16334 20557-20567 Positive_regulation denotes Activation
T16332 21839-21843 Protein denotes CD28
T16331 21769-21773 Protein denotes AP-1
T16330 21697-21702 Protein denotes IκB-α
T16329 21655-21660 Protein denotes IκB-α
T16328 21608-21613 Protein denotes IL-17
T16327 21346-21350 Protein denotes CD28
T16326 21227-21232 Protein denotes c-Rel
T16325 21200-21203 Protein denotes p50
T16324 21192-21195 Protein denotes p65
T16323 21024-21028 Protein denotes CD28
T16322 21081-21086 Protein denotes IL-17
T16321 20931-20936 Protein denotes IL-17
T16320 20806-20811 Protein denotes IL-17
T16319 20770-20775 Protein denotes IL-15
T16318 20762-20765 Protein denotes PHA
T16317 20740-20744 Protein denotes CD28
T16316 20627-20632 Protein denotes IL-17
T16315 20606-20610 Protein denotes AP-1
T16314 20585-20604 Protein denotes activator protein-1
T15210 20425-20439 Phosphorylation denotes phosphorylated
T15209 20273-20291 Phosphorylation denotes non-phosphorylated
T15208 20121-20135 Phosphorylation denotes phosphorylated
T15207 20140-20149 Positive_regulation denotes increased
T15206 20022-20032 Regulation denotes difference
T15205 20051-20065 Phosphorylation denotes phosphorylated
T15204 19890-19900 Positive_regulation denotes activation
T15203 19786-19796 Gene_expression denotes production
T15202 19726-19736 Positive_regulation denotes Activation
T15201 20382-20387 Protein denotes IL-15
T15200 20358-20361 Protein denotes PHA
T15199 20440-20443 Protein denotes Akt
T15198 20300-20307 Protein denotes β-actin
T15197 20292-20295 Protein denotes Akt
T15196 20136-20139 Protein denotes Akt
T15195 20066-20069 Protein denotes Akt
T15194 19904-19907 Protein denotes Akt
T15193 19780-19785 Protein denotes IL-17
T15192 19745-19748 Protein denotes Akt
T14596 19565-19573 Positive_regulation denotes increase
T14595 19588-19599 Transcription denotes transcripts
T14594 19382-19390 Positive_regulation denotes enhanced
T14593 19417-19426 Regulation denotes regulated
T14592 19397-19407 Gene_expression denotes production
T14591 19345-19355 Transcription denotes expression
T14590 19577-19582 Protein denotes IL-17
T14589 19391-19396 Protein denotes IL-17
T14588 19334-19339 Protein denotes IL-17
T13974 19080-19090 Gene_expression denotes production
T13973 19059-19070 Negative_regulation denotes inhibitions
T13972 19013-19023 Gene_expression denotes production
T13971 18993-19003 Negative_regulation denotes inhibition
T13970 18616-18626 Negative_regulation denotes inhibitors
T13969 18810-18816 Regulation denotes effect
T13968 18656-18669 Negative_regulation denotes downregulated
T13967 18680-18689 Localization denotes secretion
T13966 18492-18502 Gene_expression denotes production
T13965 18469-18485 Positive_regulation denotes anti-CD3-induced
T13964 18455-18464 Negative_regulation denotes inhibited
T13963 18203-18213 Gene_expression denotes production
T13962 18168-18176 Negative_regulation denotes decrease
T13961 18180-18196 Positive_regulation denotes anti-CD3-induced
T13960 18013-18022 Positive_regulation denotes increased
T13959 18029-18039 Gene_expression denotes production
T13958 17923-17933 Gene_expression denotes production
T13957 17903-17913 Negative_regulation denotes Inhibition
T13956 19074-19079 Protein denotes IL-17
T13955 19007-19012 Protein denotes IL-17
T13954 18820-18825 Protein denotes IL-17
T13953 18674-18679 Protein denotes IL-17
T13952 18604-18615 Protein denotes calcineurin
T13951 18486-18491 Protein denotes IL-17
T13950 18197-18202 Protein denotes IL-17
T13949 18023-18028 Protein denotes IL-17
T13948 17917-17922 Protein denotes IL-17
T12949 17690-17703 Positive_regulation denotes upregulations
T12948 17426-17434 Positive_regulation denotes increase
T12947 17602-17611 Regulation denotes unchanged
T12946 17399-17409 Gene_expression denotes production
T12945 17346-17353 Regulation denotes effects
T12944 17207-17215 Regulation denotes affected
T12943 17220-17230 Gene_expression denotes production
T12942 16970-16980 Regulation denotes Regulation
T12941 16990-17000 Gene_expression denotes production
T12940 17873-17879 Protein denotes MIP-1β
T12939 17852-17858 Protein denotes MIP-1α
T12938 17835-17839 Protein denotes IL-8
T12937 17707-17712 Protein denotes IL-17
T12936 17661-17665 Protein denotes IL-6
T12935 17641-17646 Protein denotes MCP-1
T12934 17560-17565 Protein denotes TGF-β
T12933 17540-17545 Protein denotes IL-18
T12932 17522-17527 Protein denotes TNF-α
T12931 17504-17509 Protein denotes IL-1β
T12930 17473-17478 Protein denotes IL-15
T12929 17438-17443 Protein denotes IL-17
T12928 17591-17596 Protein denotes IL-17
T12927 17393-17398 Protein denotes IL-17
T12926 17234-17239 Protein denotes IL-17
T12925 16984-16989 Protein denotes IL-17
T12075 16862-16872 Gene_expression denotes production
T12074 16846-16855 Positive_regulation denotes increased
T12073 16623-16634 Positive_regulation denotes upregulated
T12072 16714-16722 Gene_expression denotes produced
T12071 16641-16651 Gene_expression denotes production
T12070 16451-16459 Positive_regulation denotes increase
T12069 16136-16146 Gene_expression denotes production
T12068 16120-16129 Positive_regulation denotes Increased
T12067 16841-16844 Protein denotes PHA
T12066 16921-16925 Protein denotes CD28
T12065 16856-16861 Protein denotes IL-17
T12064 16728-16733 Protein denotes IL-17
T12063 16696-16700 Protein denotes CD28
T12062 16635-16640 Protein denotes IL-17
T12061 16463-16468 Protein denotes IL-17
T12060 16221-16226 Protein denotes IL-17
T12059 16209-16212 Protein denotes PHA
T12058 16199-16203 Protein denotes CD28
T12057 16130-16135 Protein denotes IL-17
T11414 15952-15962 Positive_regulation denotes stimulated
T11413 15941-15951 Gene_expression denotes production
T11412 15815-15824 Localization denotes secretion
T11411 15988-15994 Positive_regulation denotes higher
T11410 15499-15509 Gene_expression denotes production
T11409 15966-15969 Protein denotes PHA
T11408 15935-15940 Protein denotes IL-17
T11407 15809-15814 Protein denotes IL-17
T11406 15707-15712 Protein denotes IL-17
T11405 15619-15622 Protein denotes PHA
T11404 15493-15498 Protein denotes IL-17
T10448 14837-14842 Protein denotes c-Rel
T10447 14829-14832 Protein denotes p65
T10446 14824-14827 Protein denotes p50
T10445 13930-13935 Protein denotes IL-17
T9669 13281-13295 Phosphorylation denotes phosphorylated
T9668 12526-12540 Phosphorylation denotes phosphorylated
T9667 13304-13309 Protein denotes IκB-α
T9666 13296-13299 Protein denotes Akt
T9665 13276-13279 Protein denotes Akt
T9664 12549-12554 Protein denotes IκB-α
T9663 12541-12544 Protein denotes Akt
T9662 12521-12524 Protein denotes Akt
T8738 12480-12485 Protein denotes GAPDH
T8737 12457-12462 Protein denotes IL-17
T8736 12287-12292 Protein denotes GAPDH
T8735 12297-12302 Protein denotes IL-17
T8734 12186-12191 Protein denotes IL-17
T8733 12176-12181 Protein denotes GAPDH
T8732 11957-11962 Protein denotes GAPDH
T8731 11910-11915 Protein denotes GAPDH
T8730 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8729 11760-11765 Protein denotes IL-17
T8728 11497-11500 Protein denotes Taq
T8727 10920-10925 Protein denotes IL-17
T7826 10878-10883 Protein denotes IL-17
T7825 10631-10636 Protein denotes IL-17
T7824 10583-10588 Protein denotes IL-17
T7823 10140-10145 Protein denotes IL-17
T7822 9885-9890 Protein denotes IL-17
T7821 9669-9674 Protein denotes IL-17
T7820 9463-9468 Protein denotes IL-17
T7819 9457-9462 Protein denotes IL-17
T6962 9400-9403 Protein denotes CD4
T6961 9052-9055 Protein denotes CD4
T6960 8506-8509 Protein denotes CD4
T6959 8357-8360 Protein denotes CD4
T6958 8322-8325 Protein denotes CD4
T6287 7291-7301 Gene_expression denotes Production
T6286 7305-7310 Protein denotes IL-17
T5619 7106-7110 Protein denotes CD28
T5618 6921-6924 Protein denotes PHA
T5617 6901-6919 Protein denotes Phytohemagglutinin
T5616 6777-6781 Protein denotes IL-1
T5615 6767-6772 Protein denotes TNF-α
T5614 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5613 6602-6606 Protein denotes IL-8
T5612 6593-6597 Protein denotes IL-6
T5611 6585-6591 Protein denotes MIP-1β
T5610 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5609 6535-6540 Protein denotes MCP-1
T5608 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5607 6492-6497 Protein denotes IL-15
T5606 6485-6490 Protein denotes IL-18
T5605 6478-6483 Protein denotes IL-17
T3761 5458-5472 Gene_expression denotes overproduction
T3760 5442-5450 Regulation denotes involved
T3759 5247-5257 Gene_expression denotes production
T3730 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3729 4108-4113 Protein denotes RANKL
T3728 4035-4040 Protein denotes IL-17
T3727 3920-3925 Protein denotes IL-17
T3726 3914-3918 Protein denotes IL-1
T3725 3904-3909 Protein denotes TNF-α
T3724 3807-3811 Protein denotes IL-8
T3723 3798-3802 Protein denotes IL-6
T3722 3700-3705 Protein denotes IL-17
T3721 3325-3330 Protein denotes TNF-α
T3720 3315-3320 Protein denotes IL-18
T3719 3308-3313 Protein denotes IL-15
T3718 3302-3306 Protein denotes IL-6
T3717 3296-3300 Protein denotes IL-1
T3716 3208-3220 Protein denotes interferon-γ
T3715 3199-3203 Protein denotes IL-2
T3714 2762-2780 Protein denotes interleukin (IL)-1
T3713 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T3758 5151-5161 Gene_expression denotes production
T3757 4932-4942 Gene_expression denotes production
T3756 4635-4643 Localization denotes secreted
T3755 4709-4716 Positive_regulation denotes trigger
T3754 4726-4736 Gene_expression denotes production
T3753 4578-4586 Gene_expression denotes produced
T3752 4225-4235 Positive_regulation denotes stimulates
T3751 4240-4250 Gene_expression denotes production
T3750 4181-4189 Regulation denotes involved
T3749 4050-4058 Positive_regulation denotes activate
T3748 4095-4104 Positive_regulation denotes induction
T3747 3791-3797 Positive_regulation denotes induce
T3746 2713-2723 Negative_regulation denotes inhibitors
T3745 5506-5511 Protein denotes IL-17
T3744 5419-5422 Protein denotes Akt
T3743 5241-5246 Protein denotes IL-17
T3742 5145-5150 Protein denotes IL-17
T3741 5010-5015 Protein denotes IL-17
T3740 4962-4965 Protein denotes CD8
T3739 4953-4956 Protein denotes CD4
T3738 4926-4931 Protein denotes IL-17
T3737 4887-4892 Protein denotes IL-23
T3736 4720-4725 Protein denotes IL-17
T3735 4628-4633 Protein denotes IL-15
T3734 4590-4593 Protein denotes CD4
T3733 4453-4458 Protein denotes IL-17
T3732 4263-4289 Protein denotes leukemia inhibitory factor
T3731 4254-4258 Protein denotes IL-6
T1335 2345-2359 Gene_expression denotes overproduction
T1334 2225-2235 Gene_expression denotes production
T1333 2212-2218 Regulation denotes affect
T1332 2124-2134 Negative_regulation denotes inhibition
T1331 2066-2075 Negative_regulation denotes inhibitor
T1330 1918-1928 Gene_expression denotes production
T1329 1974-1981 Negative_regulation denotes blocked
T1328 1482-1493 Positive_regulation denotes upregulated
T1327 1500-1510 Gene_expression denotes production
T1326 1296-1305 Positive_regulation denotes increased
T1325 1258-1268 Gene_expression denotes production
T1324 856-866 Regulation denotes regulation
T1323 876-886 Gene_expression denotes production
T1322 654-664 Gene_expression denotes production
T1321 708-716 Regulation denotes regulate
T1320 639-647 Regulation denotes regulate
T1319 723-733 Gene_expression denotes production
T1318 461-471 Gene_expression denotes expression
T1315 2393-2398 Protein denotes IL-17
T1314 2311-2314 Protein denotes Akt
T1313 2219-2224 Protein denotes IL-17
T1312 2202-2203 Protein denotes 2
T1311 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T1310 2138-2157 Protein denotes activator protein-1
T1309 2062-2065 Protein denotes Akt
T1308 1912-1917 Protein denotes IL-17
T1307 1783-1786 Protein denotes Akt
T1306 1610-1615 Protein denotes IL-17
T1305 1572-1600 Protein denotes transforming growth factor-β
T1304 1563-1568 Protein denotes IL-18
T1303 1556-1561 Protein denotes IL-1β
T1302 1531-1554 Protein denotes tumor necrosis factor-α
T1301 1494-1499 Protein denotes IL-17
T1300 1477-1481 Protein denotes IL-6
T1299 1438-1472 Protein denotes monocyte chemoattractant protein-1
T1298 1431-1436 Protein denotes IL-15
T1297 1376-1379 Protein denotes PHA
T1296 1367-1371 Protein denotes CD28
T1295 1272-1277 Protein denotes IL-17
T1294 1126-1131 Protein denotes IL-17
T1293 1070-1073 Protein denotes PHA
T1292 1050-1068 Protein denotes phytohemagglutinin
T1291 1044-1048 Protein denotes CD28
T1290 837-840 Protein denotes Akt
T1289 870-875 Protein denotes IL-17
T1288 717-722 Protein denotes IL-17
T1287 648-653 Protein denotes IL-17
T1286 610-615 Protein denotes IL-23
T1285 600-605 Protein denotes IL-15
T1284 504-509 Protein denotes IL-17
T1283 273-292 Protein denotes Interleukin (IL)-17
R518 T1281 T1316 themeOf interleukin-17,production
R519 T1284 T1318 themeOf IL-17,expression
R520 T1287 T1322 themeOf IL-17,production
R521 T1288 T1319 themeOf IL-17,production
R522 T1289 T1323 themeOf IL-17,production
R523 T1295 T1325 themeOf IL-17,production
R524 T1297 T1326 causeOf PHA,increased
R525 T1301 T1327 themeOf IL-17,production
R526 T1308 T1330 themeOf IL-17,production
R527 T1309 T1331 themeOf Akt,inhibitor
R528 T1310 T1332 themeOf activator protein-1,inhibition
R529 T1311 T1332 themeOf extracellular signal-regulated kinase 1,inhibition
R530 T1313 T1334 themeOf IL-17,production
R531 T1315 T1335 themeOf IL-17,overproduction
R532 T1316 T1317 themeOf production,Increased
R533 T1319 T1321 themeOf production,regulate
R534 T1322 T1320 themeOf production,regulate
R535 T1323 T1324 themeOf production,regulation
R536 T1325 T1326 themeOf production,increased
R537 T1327 T1328 themeOf production,upregulated
R538 T1330 T1329 themeOf production,blocked
R539 T1332 T1333 causeOf inhibition,affect
R540 T1332 T1333 causeOf inhibition,affect
R541 T1334 T1333 themeOf production,affect
R542 T1334 T1333 themeOf production,affect
R1776 T3713 T3746 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1777 T3714 T3746 themeOf interleukin (IL)-1,inhibitors
R1778 T3723 T3747 themeOf IL-6,induce
R1779 T3724 T3747 themeOf IL-8,induce
R1781 T3728 T3749 causeOf IL-17,activate
R1783 T3729 T3748 themeOf RANKL,induction
R1784 T3731 T3751 themeOf IL-6,production
R1788 T3732 T3751 themeOf leukemia inhibitory factor,production
R1789 T3733 T3753 themeOf IL-17,produced
R1792 T3735 T3756 themeOf IL-15,secreted
R1795 T3736 T3754 themeOf IL-17,production
R1799 T3738 T3757 themeOf IL-17,production
R1801 T3742 T3758 themeOf IL-17,production
R1805 T3743 T3759 themeOf IL-17,production
R1808 T3745 T3761 themeOf IL-17,overproduction
R1812 T3748 T3750 themeOf induction,involved
R1815 T3748 T3749 themeOf induction,activate
R1817 T3751 T3752 themeOf production,stimulates
R1818 T3751 T3752 themeOf production,stimulates
R1819 T3754 T3755 themeOf production,trigger
R1820 T3761 T3760 themeOf overproduction,involved
R3324 T6286 T6287 themeOf IL-17,Production
R5070 T9663 T9668 themeOf Akt,phosphorylated
R5071 T9666 T9669 themeOf Akt,phosphorylated
R5072 T9667 T9669 themeOf IκB-α,phosphorylated
R6147 T11404 T11410 themeOf IL-17,production
R6148 T11407 T11412 themeOf IL-17,secretion
R6149 T11408 T11413 themeOf IL-17,production
R6150 T11409 T11411 themeOf PHA,higher
R6151 T11413 T11414 themeOf production,stimulated
R6511 T12057 T12069 themeOf IL-17,production
R6512 T12061 T12070 themeOf IL-17,increase
R6513 T12062 T12071 themeOf IL-17,production
R6514 T12064 T12072 themeOf IL-17,produced
R6515 T12065 T12075 themeOf IL-17,production
R6516 T12069 T12068 themeOf production,Increased
R6517 T12071 T12073 themeOf production,upregulated
R6518 T12075 T12074 themeOf production,increased
R6995 T12925 T12941 themeOf IL-17,production
R6996 T12926 T12943 themeOf IL-17,production
R6997 T12927 T12946 themeOf IL-17,production
R6998 T12928 T12947 themeOf IL-17,unchanged
R6999 T12929 T12948 themeOf IL-17,increase
R7000 T12931 T12947 themeOf IL-1β,unchanged
R7001 T12932 T12947 themeOf TNF-α,unchanged
R7002 T12937 T12949 themeOf IL-17,upregulations
R7003 T12941 T12942 themeOf production,Regulation
R7004 T12943 T12944 themeOf production,affected
R7005 T12946 T12945 themeOf production,effects
R7589 T13948 T13958 themeOf IL-17,production
R7590 T13949 T13959 themeOf IL-17,production
R7591 T13950 T13963 themeOf IL-17,production
R7592 T13951 T13966 themeOf IL-17,production
R7593 T13952 T13970 themeOf calcineurin,inhibitors
R7594 T13953 T13967 themeOf IL-17,secretion
R7595 T13954 T13969 themeOf IL-17,effect
R7596 T13955 T13972 themeOf IL-17,production
R7597 T13956 T13974 themeOf IL-17,production
R7598 T13958 T13957 themeOf production,Inhibition
R7599 T13959 T13960 themeOf production,increased
R7600 T13963 T13962 themeOf production,decrease
R7601 T13963 T13961 themeOf production,anti-CD3-induced
R7602 T13966 T13964 themeOf production,inhibited
R7603 T13966 T13965 themeOf production,anti-CD3-induced
R7604 T13967 T13968 themeOf secretion,downregulated
R7605 T13972 T13971 themeOf production,inhibition
R7606 T13974 T13973 themeOf production,inhibitions
R8041 T14588 T14591 themeOf IL-17,expression
R8042 T14589 T14592 themeOf IL-17,production
R8043 T14590 T14596 themeOf IL-17,increase
R8044 T14590 T14595 themeOf IL-17,transcripts
R8045 T14592 T14594 themeOf production,enhanced
R8046 T14592 T14593 themeOf production,regulated
R8330 T15193 T15203 themeOf IL-17,production
R8331 T15194 T15204 themeOf Akt,activation
R8332 T15195 T15205 themeOf Akt,phosphorylated
R8333 T15196 T15207 themeOf Akt,increased
R8334 T15196 T15208 themeOf Akt,phosphorylated
R8335 T15197 T15209 themeOf Akt,non-phosphorylated
R8336 T15199 T15210 themeOf Akt,phosphorylated
R8337 T15203 T15202 themeOf production,Activation
R8338 T15205 T15206 themeOf phosphorylated,difference
R8339 T15208 T15207 causeOf phosphorylated,increased
R8861 T16315 T16334 themeOf AP-1,Activation
R8862 T16318 T16336 themeOf PHA,activated
R8863 T16319 T16336 causeOf IL-15,activated
R8864 T16320 T16335 themeOf IL-17,expression
R8865 T16322 T16339 themeOf IL-17,binding
R8866 T16330 T16340 themeOf IκB-α,degradation
R8867 T16333 T16342 themeOf IL-17,production
R8868 T16335 T16337 themeOf expression,inducing
R8869 T16339 T16338 themeOf binding,increased
R8870 T16340 T16341 themeOf degradation,inhibition
R10594 T20046 T20109 themeOf IL-17,production
R10595 T20048 T20113 themeOf IL-17,production
R10596 T20050 T20111 themeOf IL-17,production
R10597 T20051 T20115 causeOf PHA,increased
R10598 T20053 T20114 themeOf IL-17,production
R10599 T20054 T20116 themeOf IL-17,upregulation
R10600 T20055 T20117 themeOf IL-17,produced
R10601 T20059 T20118 themeOf IL-17,production
R10602 T20061 T20120 themeOf IL-6,secrete
R10603 T20062 T20120 themeOf IL-8,secrete
R10604 T20063 T20120 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10605 T20064 T20122 themeOf IL-17,production
R10606 T20067 T20121 themeOf IL-17,production
R10607 T20068 T20125 themeOf IL-17,production
R10608 T20070 T20127 themeOf IL-15,ligation
R10609 T20070 T20128 causeOf IL-15,increased
R10610 T20071 T20127 themeOf MCP-1,ligation
R10611 T20071 T20128 causeOf MCP-1,increased
R10612 T20072 T20126 themeOf IL-17,production
R10613 T20073 T20130 themeOf IL-15,Adding
R10614 T20074 T20130 themeOf MCP-1,Adding
R10615 T20075 T20129 themeOf IL-17,production
R10616 T20076 T20132 themeOf IL-1,increased
R10617 T20076 T20134 causeOf IL-1,affect
R10618 T20078 T20133 themeOf IL-17,production
R10619 T20079 T20135 causeOf IL-15,triggered
R10620 T20080 T20136 themeOf IL-17,production
R10621 T20082 T20137 themeOf MCP-1,induces
R10622 T20084 T20138 themeOf IL-17,induction
R10623 T20086 T20140 themeOf IL-17,production
R10624 T20087 T20143 themeOf IL-17,induction
R10625 T20089 T20145 themeOf IL-17,production
R10626 T20090 T20148 themeOf IL-17,production
R10627 T20091 T20150 themeOf IκB kinase-β,activated
R10628 T20092 T20151 themeOf p300,involving
R10629 T20094 T20152 themeOf IL-17,production
R10630 T20095 T20154 themeOf Akt,activation
R10631 T20096 T20157 themeOf Akt,phosphorylated
R10632 T20097 T20156 themeOf IL-17,induction
R10633 T20100 T20159 themeOf IL-17,induction
R10634 T20102 T20161 themeOf Akt,association
R10635 T20103 T20160 themeOf IL-17,lacking
R10636 T20105 T20162 themeOf IL-17,upregulation
R10637 T20107 T20163 themeOf IL-17,induction
R10638 T20109 T20110 themeOf production,regulated
R10639 T20111 T20112 themeOf production,stimulate
R10640 T20114 T20115 themeOf production,increased
R10641 T20118 T20119 themeOf production,augmented
R10642 T20121 T20124 themeOf production,regulate
R10643 T20122 T20123 themeOf production,stimulate
R10644 T20126 T20128 themeOf production,increased
R10645 T20126 T20128 themeOf production,increased
R10646 T20126 T20128 themeOf production,increased
R10647 T20126 T20128 themeOf production,increased
R10648 T20127 T20128 causeOf ligation,increased
R10649 T20127 T20128 causeOf ligation,increased
R10650 T20129 T20131 themeOf production,augmented
R10651 T20133 T20134 themeOf production,affect
R10652 T20136 T20135 themeOf production,triggered
R10653 T20138 T20139 themeOf induction,increases
R10654 T20140 T20141 themeOf production,regulated
R10655 T20143 T20142 themeOf induction,involved
R10656 T20145 T20144 themeOf production,hampered
R10657 T20145 T20146 themeOf production,induced
R10658 T20148 T20149 themeOf production,anti-CD3-induced
R10659 T20148 T20147 themeOf production,downregulated
R10660 T20154 T20153 themeOf activation,response
R10661 T20156 T20155 themeOf induction,involvement
R10662 T20159 T20158 themeOf induction,involved
R12206 T22403 T22412 themeOf IL-17,production
R12207 T22404 T22411 themeOf IL-15,response
R12208 T22405 T22411 themeOf MCP-1,response
R12209 T22407 T22413 themeOf IL-17,upregulation
R12210 T22409 T22414 themeOf IL-17,production
R12211 T22414 T22415 themeOf production,regulation

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T1985 10-24 Protein denotes interleukin-17
T1986 68-71 Protein denotes Akt
T2020 0-9 Positive_regulation denotes Increased
T2021 25-35 Gene_expression denotes production
T22618 28503-28513 Gene_expression denotes production
T22617 28483-28493 Regulation denotes regulation
T22616 28270-28282 Positive_regulation denotes upregulation
T22615 28136-28146 Gene_expression denotes production
T22614 28172-28180 Positive_regulation denotes response
T22613 28675-28680 Protein denotes IL-17
T22612 28497-28502 Protein denotes IL-17
T22611 28380-28383 Protein denotes Akt
T22610 28286-28291 Protein denotes IL-17
T22609 28240-28244 Protein denotes CD28
T22608 28194-28199 Protein denotes MCP-1
T22607 28184-28189 Protein denotes IL-15
T22606 28150-28155 Protein denotes IL-17
T21980 27897-27906 Positive_regulation denotes induction
T21979 27678-27690 Positive_regulation denotes upregulation
T21978 27760-27768 Negative_regulation denotes blocking
T21977 27554-27561 Negative_regulation denotes lacking
T21976 27174-27183 Positive_regulation denotes induction
T21975 26873-26887 Phosphorylation denotes phosphorylated
T21974 26936-26947 Regulation denotes involvement
T21973 26963-26972 Positive_regulation denotes induction
T21972 26788-26798 Positive_regulation denotes activation
T21971 26649-26659 Gene_expression denotes production
T21970 26236-26245 Positive_regulation denotes activated
T21969 26041-26051 Gene_expression denotes production
T21968 26056-26069 Negative_regulation denotes downregulated
T21967 26018-26034 Positive_regulation denotes anti-CD3-induced
T21966 25814-25821 Positive_regulation denotes induced
T21965 25828-25838 Gene_expression denotes production
T21964 25755-25764 Positive_regulation denotes induction
T21963 25582-25592 Gene_expression denotes production
T21962 25600-25609 Regulation denotes regulated
T21961 25383-25392 Positive_regulation denotes increases
T21960 25399-25408 Positive_regulation denotes induction
T21959 25031-25040 Positive_regulation denotes triggered
T21958 25056-25066 Gene_expression denotes production
T21957 24949-24955 Regulation denotes affect
T21956 24962-24972 Gene_expression denotes production
T21955 24747-24753 Positive_regulation denotes Adding
T21954 24801-24811 Gene_expression denotes production
T21953 24785-24794 Positive_regulation denotes augmented
T21952 24678-24686 Binding denotes ligation
T21951 24701-24710 Positive_regulation denotes increased
T21950 24715-24725 Gene_expression denotes production
T21949 24457-24467 Gene_expression denotes production
T21948 24383-24391 Regulation denotes regulate
T21947 24304-24314 Gene_expression denotes production
T21946 24288-24297 Positive_regulation denotes stimulate
T21945 24398-24408 Gene_expression denotes production
T21944 24095-24102 Localization denotes secrete
T21943 23741-23751 Gene_expression denotes production
T21942 23770-23779 Positive_regulation denotes augmented
T21941 23495-23503 Gene_expression denotes produced
T21940 23381-23393 Positive_regulation denotes upregulation
T21939 23261-23271 Gene_expression denotes production
T21938 23245-23254 Positive_regulation denotes increased
T21937 22975-22984 Positive_regulation denotes stimulate
T21936 23045-23055 Gene_expression denotes production
T21935 22991-23001 Gene_expression denotes production
T21934 22766-22775 Regulation denotes regulated
T21933 22752-22762 Gene_expression denotes production
T21932 27996-28001 Protein denotes IL-17
T21931 27915-27920 Protein denotes IL-17
T21930 27802-27807 Protein denotes IL-17
T21929 27694-27699 Protein denotes IL-17
T21928 27603-27606 Protein denotes Akt
T21927 27544-27549 Protein denotes IL-17
T21926 27413-27416 Protein denotes Akt
T21925 27222-27226 Protein denotes AP-1
T21924 27187-27192 Protein denotes IL-17
T21923 27062-27067 Protein denotes IL-15
T21922 27056-27060 Protein denotes CD28
T21921 26976-26981 Protein denotes IL-17
T21920 26866-26869 Protein denotes Akt
T21919 26784-26787 Protein denotes Akt
T21918 26643-26648 Protein denotes IL-17
T21917 26349-26369 Protein denotes CREB-binding protein
T21916 26344-26348 Protein denotes p300
T21915 26220-26232 Protein denotes IκB kinase-β
T21914 26035-26040 Protein denotes IL-17
T21913 25822-25827 Protein denotes IL-17
T21912 25810-25813 Protein denotes CD3
T21911 25768-25773 Protein denotes IL-17
T21910 25576-25581 Protein denotes IL-17
T21909 25497-25502 Protein denotes IL-17
T21908 25393-25398 Protein denotes IL-17
T21907 25373-25377 Protein denotes CD28
T21906 25139-25144 Protein denotes MCP-1
T21905 25080-25085 Protein denotes TNF-α
T21904 25050-25055 Protein denotes IL-17
T21903 25025-25030 Protein denotes IL-15
T21902 24956-24961 Protein denotes IL-17
T21901 24849-24854 Protein denotes TNF-α
T21900 24840-24844 Protein denotes IL-1
T21899 24795-24800 Protein denotes IL-17
T21898 24763-24768 Protein denotes MCP-1
T21897 24754-24759 Protein denotes IL-15
T21896 24729-24734 Protein denotes IL-17
T21895 24657-24662 Protein denotes MCP-1
T21894 24647-24652 Protein denotes IL-15
T21893 24611-24615 Protein denotes CD28
T21892 24471-24476 Protein denotes IL-17
T21891 24392-24397 Protein denotes IL-17
T21890 24357-24362 Protein denotes IL-23
T21889 24347-24352 Protein denotes IL-15
T21888 24298-24303 Protein denotes IL-17
T21887 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T21886 24135-24139 Protein denotes IL-8
T21885 24129-24133 Protein denotes IL-6
T21884 24051-24056 Protein denotes IL-17
T21883 23735-23740 Protein denotes IL-17
T21882 23652-23657 Protein denotes IL-23
T21881 23632-23635 Protein denotes CD8
T21880 23524-23527 Protein denotes CD4
T21879 23486-23491 Protein denotes IL-17
T21878 23397-23402 Protein denotes IL-17
T21877 23255-23260 Protein denotes IL-17
T21876 23197-23201 Protein denotes CD28
T21875 23155-23158 Protein denotes PHA
T21874 22985-22990 Protein denotes IL-17
T21873 23089-23093 Protein denotes CD28
T21872 23039-23044 Protein denotes IL-17
T21871 22835-22840 Protein denotes IL-17
T21870 22746-22751 Protein denotes IL-17
T21869 22594-22599 Protein denotes IL-17
T21868 22349-22361 Protein denotes interferon-γ
T21867 22340-22344 Protein denotes IL-4
T21866 22248-22253 Protein denotes TNF-α
T21865 22239-22243 Protein denotes IL-1
T21864 22004-22009 Protein denotes IL-17
T16808 21940-21950 Gene_expression denotes production
T16807 21668-21678 Negative_regulation denotes inhibition
T16806 21682-21693 Protein_catabolism denotes degradation
T16805 21568-21573 Negative_regulation denotes block
T16804 21061-21068 Binding denotes binding
T16803 20797-20805 Positive_regulation denotes inducing
T16802 20812-20822 Gene_expression denotes expression
T16801 20557-20567 Positive_regulation denotes Activation
T16800 21934-21939 Protein denotes IL-17
T16799 21839-21843 Protein denotes CD28
T16798 21769-21773 Protein denotes AP-1
T16797 21697-21702 Protein denotes IκB-α
T16796 21655-21660 Protein denotes IκB-α
T16795 21608-21613 Protein denotes IL-17
T16794 21346-21350 Protein denotes CD28
T16793 21227-21232 Protein denotes c-Rel
T16792 21200-21203 Protein denotes p50
T16791 21192-21195 Protein denotes p65
T16790 21024-21028 Protein denotes CD28
T16789 21081-21086 Protein denotes IL-17
T16788 20931-20936 Protein denotes IL-17
T16787 20806-20811 Protein denotes IL-17
T16786 20770-20775 Protein denotes IL-15
T16785 20762-20765 Protein denotes PHA
T16784 20740-20744 Protein denotes CD28
T16783 20627-20632 Protein denotes IL-17
T16782 20606-20610 Protein denotes AP-1
T16781 20585-20604 Protein denotes activator protein-1
T15469 20415-20421 Negative_regulation denotes effect
T15468 20425-20439 Phosphorylation denotes phosphorylated
T15467 20273-20291 Phosphorylation denotes non-phosphorylated
T15466 20317-20326 Regulation denotes unchanged
T15465 20140-20149 Positive_regulation denotes increased
T15464 20121-20135 Phosphorylation denotes phosphorylated
T15463 20051-20065 Phosphorylation denotes phosphorylated
T15462 19890-19900 Positive_regulation denotes activation
T15461 19726-19736 Positive_regulation denotes Activation
T15460 19786-19796 Gene_expression denotes production
T15459 20382-20387 Protein denotes IL-15
T15458 20358-20361 Protein denotes PHA
T15457 20440-20443 Protein denotes Akt
T15456 20300-20307 Protein denotes β-actin
T15455 20292-20295 Protein denotes Akt
T15454 20136-20139 Protein denotes Akt
T15453 20066-20069 Protein denotes Akt
T15452 19904-19907 Protein denotes Akt
T15451 19780-19785 Protein denotes IL-17
T15450 19745-19748 Protein denotes Akt
T14704 19565-19573 Positive_regulation denotes increase
T14703 19588-19599 Transcription denotes transcripts
T14702 19417-19426 Regulation denotes regulated
T14701 19397-19407 Gene_expression denotes production
T14700 19382-19390 Positive_regulation denotes enhanced
T14699 19345-19355 Transcription denotes expression
T14698 19577-19582 Protein denotes IL-17
T14697 19391-19396 Protein denotes IL-17
T14696 19334-19339 Protein denotes IL-17
T14396 19080-19090 Gene_expression denotes production
T14395 19059-19070 Negative_regulation denotes inhibitions
T14394 19013-19023 Gene_expression denotes production
T14393 18993-19003 Negative_regulation denotes inhibition
T14392 18680-18689 Localization denotes secretion
T14391 18616-18626 Negative_regulation denotes inhibitors
T14390 18656-18669 Negative_regulation denotes downregulated
T14389 18810-18816 Regulation denotes effect
T14388 18492-18502 Gene_expression denotes production
T14387 18469-18485 Positive_regulation denotes anti-CD3-induced
T14386 18455-18464 Negative_regulation denotes inhibited
T14385 18203-18213 Gene_expression denotes production
T14384 18180-18196 Positive_regulation denotes anti-CD3-induced
T14383 18168-18176 Negative_regulation denotes decrease
T14382 18029-18039 Gene_expression denotes production
T14381 18013-18022 Positive_regulation denotes increased
T14380 17923-17933 Gene_expression denotes production
T14379 17903-17913 Negative_regulation denotes Inhibition
T14378 19074-19079 Protein denotes IL-17
T14377 19007-19012 Protein denotes IL-17
T14376 18820-18825 Protein denotes IL-17
T14375 18674-18679 Protein denotes IL-17
T14374 18604-18615 Protein denotes calcineurin
T14373 18486-18491 Protein denotes IL-17
T14372 18197-18202 Protein denotes IL-17
T14371 18023-18028 Protein denotes IL-17
T14370 17917-17922 Protein denotes IL-17
T13276 17690-17703 Positive_regulation denotes upregulations
T13275 17426-17434 Positive_regulation denotes increase
T13274 17602-17611 Positive_regulation denotes unchanged
T13273 17346-17353 Regulation denotes effects
T13272 17399-17409 Gene_expression denotes production
T13271 17220-17230 Gene_expression denotes production
T13270 17207-17215 Regulation denotes affected
T13269 16990-17000 Gene_expression denotes production
T13268 16970-16980 Regulation denotes Regulation
T13267 17873-17879 Protein denotes MIP-1β
T13266 17852-17858 Protein denotes MIP-1α
T13265 17835-17839 Protein denotes IL-8
T13264 17707-17712 Protein denotes IL-17
T13263 17661-17665 Protein denotes IL-6
T13262 17641-17646 Protein denotes MCP-1
T13261 17560-17565 Protein denotes TGF-β
T13260 17540-17545 Protein denotes IL-18
T13259 17522-17527 Protein denotes TNF-α
T13258 17504-17509 Protein denotes IL-1β
T13257 17473-17478 Protein denotes IL-15
T13256 17438-17443 Protein denotes IL-17
T13255 17591-17596 Protein denotes IL-17
T13254 17393-17398 Protein denotes IL-17
T13253 17234-17239 Protein denotes IL-17
T13252 16984-16989 Protein denotes IL-17
T12358 16846-16855 Positive_regulation denotes increased
T12357 16862-16872 Gene_expression denotes production
T12356 16714-16722 Gene_expression denotes produced
T12355 16623-16634 Positive_regulation denotes upregulated
T12354 16641-16651 Gene_expression denotes production
T12353 16451-16459 Positive_regulation denotes increase
T12352 16272-16280 Gene_expression denotes produced
T12351 16120-16129 Positive_regulation denotes Increased
T12350 16136-16146 Gene_expression denotes production
T12349 16841-16844 Protein denotes PHA
T12348 16921-16925 Protein denotes CD28
T12347 16856-16861 Protein denotes IL-17
T12346 16728-16733 Protein denotes IL-17
T12345 16696-16700 Protein denotes CD28
T12344 16635-16640 Protein denotes IL-17
T12343 16463-16468 Protein denotes IL-17
T12342 16221-16226 Protein denotes IL-17
T12341 16209-16212 Protein denotes PHA
T12340 16199-16203 Protein denotes CD28
T12339 16130-16135 Protein denotes IL-17
T11608 15815-15824 Localization denotes secretion
T11607 15941-15951 Gene_expression denotes production
T11606 15952-15962 Positive_regulation denotes stimulated
T11605 15499-15509 Gene_expression denotes production
T11604 15966-15969 Protein denotes PHA
T11603 15935-15940 Protein denotes IL-17
T11602 15809-15814 Protein denotes IL-17
T11601 15707-15712 Protein denotes IL-17
T11600 15619-15622 Protein denotes PHA
T11599 15493-15498 Protein denotes IL-17
T10749 14837-14842 Protein denotes c-Rel
T10748 14829-14832 Protein denotes p65
T10747 14824-14827 Protein denotes p50
T10746 13930-13935 Protein denotes IL-17
T9967 13281-13295 Phosphorylation denotes phosphorylated
T9966 12526-12540 Phosphorylation denotes phosphorylated
T9965 13304-13309 Protein denotes IκB-α
T9964 13296-13299 Protein denotes Akt
T9963 13276-13279 Protein denotes Akt
T9962 12549-12554 Protein denotes IκB-α
T9961 12541-12544 Protein denotes Akt
T9960 12521-12524 Protein denotes Akt
T9178 12480-12485 Protein denotes GAPDH
T9177 12457-12462 Protein denotes IL-17
T9176 12287-12292 Protein denotes GAPDH
T9175 12297-12302 Protein denotes IL-17
T9174 12186-12191 Protein denotes IL-17
T9173 12176-12181 Protein denotes GAPDH
T9172 11957-11962 Protein denotes GAPDH
T9171 11910-11915 Protein denotes GAPDH
T9170 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T9169 11760-11765 Protein denotes IL-17
T9168 11497-11500 Protein denotes Taq
T9167 10920-10925 Protein denotes IL-17
T8160 10878-10883 Protein denotes IL-17
T8159 10631-10636 Protein denotes IL-17
T8158 10583-10588 Protein denotes IL-17
T8157 10140-10145 Protein denotes IL-17
T8156 9885-9890 Protein denotes IL-17
T8155 9669-9674 Protein denotes IL-17
T8154 9463-9468 Protein denotes IL-17
T8153 9457-9462 Protein denotes IL-17
T7223 9400-9403 Protein denotes CD4
T7222 9052-9055 Protein denotes CD4
T7221 8506-8509 Protein denotes CD4
T7220 8357-8360 Protein denotes CD4
T7219 8322-8325 Protein denotes CD4
T6517 7291-7301 Gene_expression denotes Production
T6516 7305-7310 Protein denotes IL-17
T5894 7106-7110 Protein denotes CD28
T5893 6921-6924 Protein denotes PHA
T5892 6901-6919 Protein denotes Phytohemagglutinin
T5891 6777-6781 Protein denotes IL-1
T5890 6767-6772 Protein denotes TNF-α
T5889 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5888 6602-6606 Protein denotes IL-8
T5887 6593-6597 Protein denotes IL-6
T5886 6585-6591 Protein denotes MIP-1β
T5885 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5884 6535-6540 Protein denotes MCP-1
T5883 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5882 6492-6497 Protein denotes IL-15
T5881 6485-6490 Protein denotes IL-18
T5880 6478-6483 Protein denotes IL-17
T4648 5458-5472 Gene_expression denotes overproduction
T4647 5247-5257 Gene_expression denotes production
T4646 5151-5161 Gene_expression denotes production
T4645 4915-4922 Positive_regulation denotes trigger
T4644 4932-4942 Gene_expression denotes production
T4643 4635-4643 Localization denotes secreted
T4642 4726-4736 Gene_expression denotes production
T4641 4709-4716 Positive_regulation denotes trigger
T4640 4240-4250 Gene_expression denotes production
T4639 4225-4235 Positive_regulation denotes stimulates
T4638 4095-4104 Positive_regulation denotes induction
T4637 3743-3751 Localization denotes secreted
T4636 3791-3797 Positive_regulation denotes induce
T4635 2713-2723 Negative_regulation denotes inhibitors
T4634 5506-5511 Protein denotes IL-17
T4633 5419-5422 Protein denotes Akt
T4632 5241-5246 Protein denotes IL-17
T4631 5145-5150 Protein denotes IL-17
T4630 5010-5015 Protein denotes IL-17
T4629 4962-4965 Protein denotes CD8
T4628 4953-4956 Protein denotes CD4
T4627 4926-4931 Protein denotes IL-17
T4626 4887-4892 Protein denotes IL-23
T4625 4720-4725 Protein denotes IL-17
T4624 4628-4633 Protein denotes IL-15
T4623 4590-4593 Protein denotes CD4
T4622 4453-4458 Protein denotes IL-17
T4621 4263-4289 Protein denotes leukemia inhibitory factor
T4620 4254-4258 Protein denotes IL-6
T4619 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T4618 4108-4113 Protein denotes RANKL
T4617 4035-4040 Protein denotes IL-17
T4616 3920-3925 Protein denotes IL-17
T4615 3914-3918 Protein denotes IL-1
T4614 3904-3909 Protein denotes TNF-α
T4613 3807-3811 Protein denotes IL-8
T4612 3798-3802 Protein denotes IL-6
T4611 3700-3705 Protein denotes IL-17
T4610 3325-3330 Protein denotes TNF-α
T4609 3315-3320 Protein denotes IL-18
T4608 3308-3313 Protein denotes IL-15
T4607 3302-3306 Protein denotes IL-6
T4606 3296-3300 Protein denotes IL-1
T4605 3208-3220 Protein denotes interferon-γ
T4604 3199-3203 Protein denotes IL-2
T4603 2762-2780 Protein denotes interleukin (IL)-1
T4602 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T2038 2345-2359 Gene_expression denotes overproduction
T2037 2225-2235 Gene_expression denotes production
T2036 2212-2218 Regulation denotes affect
T2035 2124-2134 Negative_regulation denotes inhibition
T2034 1974-1981 Negative_regulation denotes blocked
T2033 1918-1928 Gene_expression denotes production
T2032 1500-1510 Gene_expression denotes production
T2031 1482-1493 Positive_regulation denotes upregulated
T2030 1258-1268 Gene_expression denotes production
T2029 1296-1305 Positive_regulation denotes increased
T2028 856-866 Regulation denotes regulation
T2027 876-886 Gene_expression denotes production
T2026 708-716 Regulation denotes regulate
T2025 654-664 Gene_expression denotes production
T2024 723-733 Gene_expression denotes production
T2023 639-647 Regulation denotes regulate
T2022 461-471 Gene_expression denotes expression
T2019 2393-2398 Protein denotes IL-17
T2018 2311-2314 Protein denotes Akt
T2017 2219-2224 Protein denotes IL-17
T2016 2202-2203 Protein denotes 2
T2015 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T2014 2138-2157 Protein denotes activator protein-1
T2013 2062-2065 Protein denotes Akt
T2012 1912-1917 Protein denotes IL-17
T2011 1783-1786 Protein denotes Akt
T2010 1610-1615 Protein denotes IL-17
T2009 1572-1600 Protein denotes transforming growth factor-β
T2008 1563-1568 Protein denotes IL-18
T2007 1556-1561 Protein denotes IL-1β
T2006 1531-1554 Protein denotes tumor necrosis factor-α
T2005 1494-1499 Protein denotes IL-17
T2004 1477-1481 Protein denotes IL-6
T2003 1438-1472 Protein denotes monocyte chemoattractant protein-1
T2002 1431-1436 Protein denotes IL-15
T2001 1376-1379 Protein denotes PHA
T2000 1367-1371 Protein denotes CD28
T1999 1272-1277 Protein denotes IL-17
T1998 1126-1131 Protein denotes IL-17
T1997 1070-1073 Protein denotes PHA
T1996 1050-1068 Protein denotes phytohemagglutinin
T1995 1044-1048 Protein denotes CD28
T1994 837-840 Protein denotes Akt
T1993 870-875 Protein denotes IL-17
T1992 717-722 Protein denotes IL-17
T1991 648-653 Protein denotes IL-17
T1990 610-615 Protein denotes IL-23
T1989 600-605 Protein denotes IL-15
T1988 504-509 Protein denotes IL-17
T1987 273-292 Protein denotes Interleukin (IL)-17
R1052 T1991 T2025 themeOf IL-17,production
R1053 T1992 T2024 themeOf IL-17,production
R1054 T1993 T2027 themeOf IL-17,production
R1055 T1999 T2030 themeOf IL-17,production
R1056 T2002 T2031 causeOf IL-15,upregulated
R1057 T2003 T2031 causeOf monocyte chemoattractant protein-1,upregulated
R1058 T2004 T2031 causeOf IL-6,upregulated
R1059 T2005 T2032 themeOf IL-17,production
R2458 T4602 T4635 themeOf tumor necrosis factor (TNF)-α,inhibitors
R2459 T4603 T4635 themeOf interleukin (IL)-1,inhibitors
R2463 T4611 T4637 themeOf IL-17,secreted
R2464 T4612 T4636 themeOf IL-6,induce
R2465 T4613 T4636 themeOf IL-8,induce
R2466 T4618 T4638 themeOf RANKL,induction
R2468 T4620 T4640 themeOf IL-6,production
R2469 T4621 T4640 themeOf leukemia inhibitory factor,production
R2470 T4624 T4643 themeOf IL-15,secreted
R2471 T4625 T4642 themeOf IL-17,production
R2472 T4626 T4645 causeOf IL-23,trigger
R2473 T4627 T4644 themeOf IL-17,production
R2475 T4631 T4646 themeOf IL-17,production
R2476 T4632 T4647 themeOf IL-17,production
R2477 T4634 T4648 themeOf IL-17,overproduction
R2479 T4640 T4639 themeOf production,stimulates
R2480 T4640 T4639 themeOf production,stimulates
R2481 T4642 T4641 themeOf production,trigger
R2482 T4644 T4645 themeOf production,trigger
R3526 T6516 T6517 themeOf IL-17,Production
R5319 T9961 T9966 themeOf Akt,phosphorylated
R5320 T9964 T9967 themeOf Akt,phosphorylated
R5321 T9965 T9967 themeOf IκB-α,phosphorylated
R6302 T11599 T11605 themeOf IL-17,production
R6303 T11602 T11608 themeOf IL-17,secretion
R6304 T11603 T11607 themeOf IL-17,production
R6305 T11607 T11606 themeOf production,stimulated
R6729 T12339 T12350 themeOf IL-17,production
R6730 T12342 T12352 themeOf IL-17,produced
R6731 T12343 T12353 themeOf IL-17,increase
R6732 T12344 T12354 themeOf IL-17,production
R6733 T12346 T12356 themeOf IL-17,produced
R6734 T12347 T12357 themeOf IL-17,production
R6735 T12350 T12351 themeOf production,Increased
R6736 T12354 T12355 themeOf production,upregulated
R6737 T12357 T12358 themeOf production,increased
R7240 T13252 T13269 themeOf IL-17,production
R7241 T13253 T13271 themeOf IL-17,production
R7242 T13254 T13272 themeOf IL-17,production
R7243 T13255 T13274 themeOf IL-17,unchanged
R7244 T13256 T13275 themeOf IL-17,increase
R7245 T13258 T13274 themeOf IL-1β,unchanged
R7246 T13259 T13274 themeOf TNF-α,unchanged
R7247 T13261 T13274 themeOf TGF-β,unchanged
R7248 T13264 T13276 themeOf IL-17,upregulations
R7249 T13269 T13268 themeOf production,Regulation
R7250 T13271 T13270 themeOf production,affected
R7251 T13272 T13273 themeOf production,effects
R7937 T14370 T14380 themeOf IL-17,production
R7938 T14371 T14382 themeOf IL-17,production
R7939 T14372 T14385 themeOf IL-17,production
R7940 T14373 T14388 themeOf IL-17,production
R7941 T14374 T14391 themeOf calcineurin,inhibitors
R7942 T14375 T14392 themeOf IL-17,secretion
R7943 T14376 T14389 themeOf IL-17,effect
R7944 T14377 T14394 themeOf IL-17,production
R7945 T14378 T14396 themeOf IL-17,production
R7946 T14380 T14379 themeOf production,Inhibition
R7947 T14382 T14381 themeOf production,increased
R7948 T14385 T14383 themeOf production,decrease
R7949 T14385 T14384 themeOf production,anti-CD3-induced
R7950 T14388 T14386 themeOf production,inhibited
R7951 T14388 T14387 themeOf production,anti-CD3-induced
R7952 T14392 T14390 themeOf secretion,downregulated
R7953 T14394 T14393 themeOf production,inhibition
R7954 T14396 T14395 themeOf production,inhibitions
R8125 T14696 T14699 themeOf IL-17,expression
R8126 T14697 T14701 themeOf IL-17,production
R8127 T14698 T14704 themeOf IL-17,increase
R8128 T14698 T14703 themeOf IL-17,transcripts
R8129 T14701 T14700 themeOf production,enhanced
R8130 T14701 T14702 themeOf production,regulated
R8131 T14703 T14704 themeOf transcripts,increase
R8531 T15451 T15460 themeOf IL-17,production
R8532 T15452 T15462 themeOf Akt,activation
R8533 T15453 T15463 themeOf Akt,phosphorylated
R8534 T15454 T15465 themeOf Akt,increased
R8535 T15454 T15464 themeOf Akt,phosphorylated
R8536 T15455 T15467 themeOf Akt,non-phosphorylated
R8537 T15455 T15466 themeOf Akt,unchanged
R8538 T15456 T15466 themeOf β-actin,unchanged
R8539 T15457 T15469 themeOf Akt,effect
R8540 T15457 T15468 themeOf Akt,phosphorylated
R8541 T15460 T15461 themeOf production,Activation
R9191 T16782 T16801 themeOf AP-1,Activation
R9192 T16787 T16802 themeOf IL-17,expression
R9193 T16789 T16804 themeOf IL-17,binding
R9194 T16795 T16805 themeOf IL-17,block
R9195 T16797 T16806 themeOf IκB-α,degradation
R9196 T16800 T16808 themeOf IL-17,production
R9197 T16802 T16803 themeOf expression,inducing
R9198 T16806 T16807 themeOf degradation,inhibition
R11996 T21935 T21937 themeOf production,stimulate
R11997 T21870 T21933 themeOf IL-17,production
R11998 T21872 T21936 themeOf IL-17,production
R11999 T21939 T21938 themeOf production,increased
R12000 T21874 T21935 themeOf IL-17,production
R12001 T21877 T21939 themeOf IL-17,production
R12002 T21878 T21940 themeOf IL-17,upregulation
R12003 T21943 T21942 themeOf production,augmented
R12004 T21879 T21941 themeOf IL-17,produced
R12005 T21945 T21948 themeOf production,regulate
R12006 T21883 T21943 themeOf IL-17,production
R12007 T21885 T21944 themeOf IL-6,secrete
R12008 T21945 T21948 themeOf production,regulate
R12009 T21886 T21944 themeOf IL-8,secrete
R12010 T21947 T21946 themeOf production,stimulate
R12011 T21887 T21944 themeOf tumor necrosis factor-stimulated gene 6,secrete
R12012 T21888 T21947 themeOf IL-17,production
R12013 T21889 T21948 causeOf IL-15,regulate
R12014 T21950 T21951 themeOf production,increased
R12015 T21890 T21948 causeOf IL-23,regulate
R12016 T21891 T21945 themeOf IL-17,production
R12017 T21892 T21949 themeOf IL-17,production
R12018 T21954 T21953 themeOf production,augmented
R12019 T21895 T21952 themeOf MCP-1,ligation
R12020 T21895 T21951 causeOf MCP-1,increased
R12021 T21896 T21950 themeOf IL-17,production
R12022 T21897 T21955 themeOf IL-15,Adding
R12023 T21898 T21955 themeOf MCP-1,Adding
R12024 T21899 T21954 themeOf IL-17,production
R12025 T21900 T21957 causeOf IL-1,affect
R12026 T21901 T21957 causeOf TNF-α,affect
R12027 T21954 T21953 themeOf production,augmented
R12028 T21902 T21956 themeOf IL-17,production
R12029 T21904 T21958 themeOf IL-17,production
R12030 T21955 T21953 causeOf Adding,augmented
R12031 T21955 T21953 causeOf Adding,augmented
R12032 T21908 T21960 themeOf IL-17,induction
R12033 T21956 T21957 themeOf production,affect
R12034 T21910 T21963 themeOf IL-17,production
R12035 T21911 T21964 themeOf IL-17,induction
R12036 T21956 T21957 themeOf production,affect
R12037 T21913 T21965 themeOf IL-17,production
R12038 T21958 T21959 themeOf production,triggered
R12039 T21914 T21969 themeOf IL-17,production
R12040 T21915 T21970 themeOf IκB kinase-β,activated
R12041 T21960 T21961 themeOf induction,increases
R12042 T21918 T21971 themeOf IL-17,production
R12043 T21919 T21972 themeOf Akt,activation
R12044 T21920 T21975 themeOf Akt,phosphorylated
R12045 T21963 T21962 themeOf production,regulated
R12046 T21921 T21973 themeOf IL-17,induction
R12047 T21924 T21976 themeOf IL-17,induction
R12048 T21965 T21966 themeOf production,induced
R12049 T21927 T21977 themeOf IL-17,lacking
R12050 T21969 T21967 themeOf production,anti-CD3-induced
R12051 T21929 T21979 themeOf IL-17,upregulation
R12052 T21930 T21978 themeOf IL-17,blocking
R12053 T21931 T21980 themeOf IL-17,induction
R12054 T21933 T21934 themeOf production,regulated
R12055 T21969 T21968 themeOf production,downregulated
R12056 T21973 T21974 themeOf induction,involvement
R12362 T22606 T22615 themeOf IL-17,production
R12363 T22608 T22614 themeOf MCP-1,response
R12364 T22610 T22616 themeOf IL-17,upregulation
R12365 T22612 T22618 themeOf IL-17,production
R12366 T22618 T22617 themeOf production,regulation
R1028 T2012 T2033 themeOf IL-17,production
R1030 T2014 T2035 themeOf activator protein-1,inhibition
R1032 T2015 T2035 themeOf extracellular signal-regulated kinase 1,inhibition
R1033 T2016 T2035 themeOf 2,inhibition
R1034 T2017 T2037 themeOf IL-17,production
R1037 T2019 T2038 themeOf IL-17,overproduction
R1038 T1985 T2020 themeOf interleukin-17,Increased
R1039 T2021 T2020 themeOf production,Increased
R1040 T2024 T2026 themeOf production,regulate
R1041 T2025 T2023 themeOf production,regulate
R1042 T2027 T2028 themeOf production,regulation
R1043 T1985 T2021 themeOf interleukin-17,production
R1044 T2030 T2029 themeOf production,increased
R1045 T1988 T2022 themeOf IL-17,expression
R1046 T2032 T2031 themeOf production,upregulated
R1047 T2032 T2031 themeOf production,upregulated
R1048 T2032 T2031 themeOf production,upregulated
R1049 T2033 T2034 themeOf production,blocked
R1050 T1990 T2023 causeOf IL-23,regulate
R1051 T2037 T2036 themeOf production,affect

2_test

Id Subject Object Predicate Lexical cue
15642134-12810425-4202008 2663-2664 12810425 denotes 1
15642134-12810200-4202009 2918-2919 12810200 denotes 2
15642134-9683554-4202010 3444-3445 9683554 denotes 3
15642134-10524679-4202011 3631-3632 10524679 denotes 4
15642134-8676080-4202012 3828-3829 8676080 denotes 5
15642134-12632409-4202013 3993-3994 12632409 denotes 6
15642134-12594294-4202014 4213-4214 12594294 denotes 7
15642134-9182915-4202015 4436-4437 9182915 denotes 8
15642134-11669582-4202015 4436-4437 11669582 denotes 8
15642134-11592370-4202015 4436-4437 11592370 denotes 8
15642134-10225978-4202016 4620-4622 10225978 denotes 11
15642134-10323452-4202017 4623-4625 10323452 denotes 12
15642134-10679127-4202018 4833-4835 10679127 denotes 13
15642134-12707317-4202019 4976-4978 12707317 denotes 14
15642134-10323452-4202020 5084-5086 10323452 denotes 12
15642134-12677240-4202021 5087-5089 12677240 denotes 15
15642134-15022319-4202022 5090-5092 15022319 denotes 16
15642134-3358796-4202023 5885-5887 3358796 denotes 17
15642134-1355500-4202024 7522-7524 1355500 denotes 18
15642134-8576572-4202025 8441-8443 8576572 denotes 19
15642134-10556691-4202026 9577-9579 10556691 denotes 20
15642134-9187742-4202027 15292-15294 9187742 denotes 21
15642134-8676080-4202028 22083-22084 8676080 denotes 5
15642134-7499828-4202029 22085-22087 7499828 denotes 22
15642134-2271017-4202030 22200-22202 2271017 denotes 23
15642134-2109776-4202031 22417-22419 2109776 denotes 24
15642134-12677240-4202032 22913-22915 12677240 denotes 15
15642134-11012616-4202033 23130-23132 11012616 denotes 25
15642134-9973376-4202034 23591-23593 9973376 denotes 26
15642134-12707317-4202035 23717-23719 12707317 denotes 14
15642134-11441109-4202036 23859-23861 11441109 denotes 27
15642134-10323452-4202037 24222-24224 10323452 denotes 12
15642134-11160281-4202038 24225-24227 11160281 denotes 28
15642134-12823853-4202039 24228-24230 12823853 denotes 29
15642134-10679127-4202040 24410-24412 10679127 denotes 13
15642134-12707317-4202041 24413-24415 12707317 denotes 14
15642134-10679127-4202042 25101-25103 10679127 denotes 13
15642134-11012616-4202043 25328-25330 11012616 denotes 25
15642134-9182915-4202044 25531-25532 9182915 denotes 8
15642134-11966773-4202045 25533-25535 11966773 denotes 30
15642134-10817568-4202046 25536-25538 10817568 denotes 31
15642134-10781614-4202047 26254-26256 10781614 denotes 32
15642134-11259436-4202048 26371-26373 11259436 denotes 33
15642134-12810200-4202049 27966-27967 12810200 denotes 2
15642134-12632409-4202050 27968-27969 12632409 denotes 6
15642134-10880256-4202051 27970-27972 10880256 denotes 34
15642134-14872510-4202051 27970-27972 14872510 denotes 34
15642134-11920418-4202051 27970-27972 11920418 denotes 34

biosemtest

Id Subject Object Predicate Lexical cue
T220 42-58 UMLS/C0031621 denotes phosphoinositide
T245 115-123 UMLS/C1578485 denotes patients
T250 115-123 UMLS/C1578484 denotes patients
T254 115-123 UMLS/C1578486 denotes patients
T258 115-123 UMLS/C1578481 denotes patients
T261 115-123 UMLS/C1578480 denotes patients
T264 115-123 UMLS/C1578483 denotes patients
T276 115-123 UMLS/C1578479 denotes patients
T292 115-123 UMLS/C0030705 denotes patients
T336 129-149 UMLS/C0003873 denotes rheumatoid arthritis
T366 36-39 UMLS/C1550513 denotes via
T394 0-9 UMLS/C0442808 denotes Increased
T397 0-9 UMLS/C0442805 denotes Increased
T402 68-71 UP/Q8INB9 denotes Akt
T431 94-103 UMLS/C1701901 denotes dependent
T434 115-123 UMLS/C1550655 denotes patients
T439 76-83 UMLS/C0521447 denotes nuclear
T447 104-111 UMLS/C1704259 denotes pathway
T461 0-9 UMLS/C0205217 denotes Increased
T469 94-103 UMLS/C0851827 denotes dependent
T484 115-123 UMLS/C1705908 denotes patients
T500 104-111 UMLS/C1705987 denotes pathway
T516 10-35 UMLS/C1819444 denotes interleukin-17 production
T17696 24146-24167 UP/P48094 denotes mor necrosis factor-s
T18051 24146-24167 UP/P23563 denotes mor necrosis factor-s
T22196 28286-28291 UMLS/C1825592 denotes IL-17
T22195 28150-28155 UMLS/C1825592 denotes IL-17
T22194 28136-28146 UMLS/C1548180 denotes production
T22193 28778-28790 UMLS/C1547755 denotes pplications
T22192 28184-28189 UMLS/C1149222 denotes IL-15
T22191 28540-28544 UMLS/C0035820 denotes ole
T22190 28762-28765 UMLS/C0205314 denotes ew
T22189 28184-28189 UMLS/C0254610 denotes IL-15
T22188 28367-28370 UMLS/C1550513 denotes via
T22187 28693-28700 UMLS/C1546471 denotes esults
T22186 28346-28352 UMLS/C1546471 denotes result
T22185 28778-28790 UMLS/C0185125 denotes pplications
T22184 28384-28391 UMLS/C1705987 denotes pathway
T22183 28109-28117 UMLS/C1511790 denotes detected
T22182 28414-28424 UMLS/C1879547 denotes ctivation.
T22181 28356-28366 UMLS/C1879547 denotes activation
T22180 28295-28304 UMLS/C1879547 denotes activated
T22179 28375-28379 UMLS/C1150481 denotes PI3K
T22178 28457-28465 UMLS/C0007634 denotes ellular
T22177 28693-28700 UMLS/C1280519 denotes esults
T22176 28346-28352 UMLS/C1280519 denotes result
T22175 28597-28609 UMLS/C0699748 denotes athogenesis.
T22174 28766-28777 UMLS/C1553525 denotes herapeutic
T22173 28778-28790 UMLS/C0870325 denotes pplications
T22172 28184-28189 UMLS/C1334105 denotes IL-15
T22171 28706-28711 UMLS/C1524062 denotes dded
T22170 28316-28324 UMLS/C1705908 denotes patients
T22169 28457-28465 UMLS/C0178539 denotes ellular
T22168 28732-28738 UMLS/C0016884 denotes uture
T22167 28693-28700 UMLS/C0332294 denotes esults
T22166 28346-28352 UMLS/C0332294 denotes result
T22165 28693-28700 UMLS/C1274040 denotes esults
T22164 28346-28352 UMLS/C1274040 denotes result
T22163 28109-28117 UMLS/C0442726 denotes detected
T22162 28211-28222 UMLS/C1948023 denotes stimulation
T22161 28194-28199 UMLS/C1522558 denotes MCP-1
T22160 28611-28619 UMLS/C1883357 denotes ogether
T22159 28766-28777 UMLS/C0302350 denotes herapeutic
T22158 28655-28667 UMLS/C1293116 denotes ntroduction
T22157 28270-28282 UMLS/C0041904 denotes upregulation
T22156 28712-28723 UMLS/C0870705 denotes nformation
T22155 28375-28379 UP/P42336 denotes PI3K
T22154 28762-28765 UMLS/C1578513 denotes ew
T22153 28286-28291 UMLS/C1522571 denotes IL-17
T22152 28150-28155 UMLS/C1522571 denotes IL-17
T22151 28316-28324 UMLS/C0030705 denotes patients
T22150 28211-28222 UMLS/C1292856 denotes stimulation
T22149 28194-28199 UMLS/C1705079 denotes MCP-1
T22148 28164-28168 UMLS/C1321301 denotes PBMC
T22147 28384-28391 UMLS/C1704259 denotes pathway
T22146 28597-28609 UMLS/C0543483 denotes athogenesis.
T22145 28286-28291 UMLS/C0384648 denotes IL-17
T22144 28150-28155 UMLS/C0384648 denotes IL-17
T22143 28316-28324 UMLS/C1578479 denotes patients
T22142 28375-28379 UMLS/C1368105 denotes PI3K
T22141 28632-28636 UMLS/C1511726 denotes ata
T22140 28430-28434 UMLS/C1511726 denotes ata
T22139 28316-28324 UMLS/C1578483 denotes patients
T22138 28316-28324 UMLS/C1578480 denotes patients
T22137 28316-28324 UMLS/C1578481 denotes patients
T22136 28316-28324 UMLS/C1578486 denotes patients
T22135 28333-28338 UMLS/C0344312 denotes could
T22134 28712-28723 UMLS/C1561528 denotes nformation
T22133 28316-28324 UMLS/C1578484 denotes patients
T22132 28316-28324 UMLS/C1578485 denotes patients
T22131 28172-28180 UMLS/C1706817 denotes response
T22130 28712-28723 UMLS/C1561527 denotes nformation
T22129 28712-28723 UMLS/C1533716 denotes nformation
T22128 28194-28199 UMLS/C1337092 denotes MCP-1
T22127 28172-28180 UMLS/C1704632 denotes response
T22126 28333-28338 UMLS/C0006823 denotes could
T22125 28625-28631 UMLS/C0332185 denotes ecent
T22124 28316-28324 UMLS/C1550655 denotes patients
T22123 28120-28124 UMLS/C0205172 denotes more
T22122 28375-28379 UMLS/C1705325 denotes PI3K
T22121 28203-28207 UMLS/C0205170 denotes well
T22120 28286-28291 UMLS/C1623218 denotes IL-17
T22119 28150-28155 UMLS/C1623218 denotes IL-17
T22118 28706-28711 UMLS/C1720086 denotes dded
T22117 28739-28758 UMLS/C1513403 denotes olecular targeting
T22116 28540-28544 UMLS/C1704326 denotes ole
T22115 28778-28790 UMLS/C1947919 denotes pplications
T22114 28466-28476 UMLS/C0441712 denotes echanisms
T22113 28766-28777 UMLS/C0039796 denotes herapeutic
T22112 28120-28124 UMLS/C0439064 denotes more
T22111 28375-28379 UMLS/C0285761 denotes PI3K
T22110 28181-28183 UMLS/C0319022 denotes to
T22109 28778-28790 UMLS/C2347934 denotes pplications
T22108 28435-28442 UMLS/C0359589 denotes rovide
T22107 28380-28383 UP/Q8INB9 denotes Akt
T22106 28778-28790 UMLS/C1533134 denotes pplications
T22105 28762-28765 UMLS/C1553390 denotes ew
T22104 28563-28566 UMLS/C2348947 denotes as
T22103 28484-28514 UMLS/C1819484 denotes egulation of IL-17 production
T22102 28706-28711 UMLS/C1883712 denotes dded
T22101 28644-28654 UMLS/C1272703 denotes uccessful
T22100 28548-28555 UMLS/C0039194 denotes cells,
T22099 28305-28312 UMLS/C0039194 denotes T cells
T22098 28540-28544 UMLS/C1705809 denotes ole
T22097 28581-28590 UMLS/C0521874 denotes eglected
T22096 28540-28544 UMLS/C1705812 denotes ole
T22095 28766-28777 UMLS/C1547427 denotes herapeutic
T22094 28540-28544 UMLS/C1705810 denotes ole
T22093 28540-28544 UMLS/C1705811 denotes ole
T22092 28466-28476 UMLS/C1706376 denotes echanisms
T22091 28172-28180 UMLS/C0871261 denotes response
T18134 23378-23382 UMLS/C0323983 denotes is u
T18133 22582-22586 UMLS/C0323983 denotes is r
T18132 24936-24942 UMLS/C0444497 denotes nts, d
T18131 24032-24038 UMLS/C0444497 denotes ints.
T18130 23917-23923 UMLS/C0444497 denotes ints m
T18129 26635-26638 UP/Q01552 denotes -κB
T18128 26285-26288 UP/Q01552 denotes sti
T18127 26257-26260 UP/Q01552 denotes , a
T18126 26208-26211 UP/Q01552 denotes n m
T18125 26635-26638 UP/O95433 denotes -κB
T18124 26285-26288 UP/O95433 denotes sti
T18123 26257-26260 UP/O95433 denotes , a
T18122 26208-26211 UP/O95433 denotes n m
T18121 25972-25982 UMLS/C1548180 denotes ction with
T18120 24717-24727 UMLS/C1548180 denotes oduction o
T18119 24459-24469 UMLS/C1548180 denotes oduction o
T18118 26654-26670 UMLS/C1819444 denotes ction needs to b
T18117 26040-26056 UMLS/C1819444 denotes production was
T18116 25826-25842 UMLS/C1819444 denotes 7 production in
T18115 25580-25596 UMLS/C1819444 denotes 7 production can
T18114 25053-25069 UMLS/C1819444 denotes 17 production in
T18113 24959-24975 UMLS/C1819444 denotes 17 production. O
T18112 24797-24813 UMLS/C1819444 denotes -17 production m
T18111 24394-24410 UMLS/C1819444 denotes -17 production [
T18110 24300-24316 UMLS/C1819444 denotes -17 production i
T18109 23737-23753 UMLS/C1819444 denotes -17 production w
T18108 23257-23273 UMLS/C1819444 denotes -17 production f
T18107 23041-23057 UMLS/C1819444 denotes -17 production c
T18106 22987-23003 UMLS/C1819444 denotes -17 production i
T18105 22748-22764 UMLS/C1819444 denotes -17 production i
T18104 24146-24167 UP/P19101 denotes mor necrosis factor-s
T18103 25034-25043 UMLS/C0032930 denotes ggered in
T18102 23660-23670 UMLS/C0032930 denotes iggering m
T18101 24278-24284 UMLS/C1551364 denotes ents t
T18100 22965-22971 UMLS/C1551364 denotes ents t
T18099 23876-23887 UMLS/C1546938 denotes teraction b
T18098 25604-25613 UMLS/C0851285 denotes lated by
T18097 24385-24393 UMLS/C0851285 denotes gulate I
T18096 22768-22777 UMLS/C0851285 denotes gulated i
T18095 24146-24167 UP/O77764 denotes mor necrosis factor-s
T18094 26554-26562 UP/O62618 denotes athway i
T18093 26411-26419 UP/O62618 denotes activati
T18092 26106-26114 UP/O62618 denotes APK inhi
T18091 23854-23859 UMLS/C0026336 denotes del [
T18090 23854-23859 UMLS/C0026339 denotes del [
T18089 23292-23306 UMLS/C1512045 denotes se-dependent m
T18088 26170-26178 UMLS/C0344211 denotes rts cros
T18087 25266-25277 UMLS/C0024432 denotes ophages in
T18086 22587-22594 UMLS/C0679133 denotes spect,
T18085 27083-27091 UMLS/C0026249 denotes our expe
T18084 24542-24550 UMLS/C0026249 denotes togens a
T18083 23164-23172 UMLS/C0026249 denotes togens,
T18082 26635-26638 UP/Q63768 denotes -κB
T18081 26285-26288 UP/Q63768 denotes sti
T18080 26257-26260 UP/Q63768 denotes , a
T18079 26208-26211 UP/Q63768 denotes n m
T18078 27514-27524 UMLS/C0007634 denotes e data on
T18077 23896-23901 UMLS/C0007634 denotes lls i
T18076 23563-23568 UMLS/C0007634 denotes lls,
T18075 23431-23439 UMLS/C0007634 denotes llular a
T18074 27319-27329 UMLS/C0282554 denotes as not act
T18073 25487-25497 UMLS/C0282554 denotes okines by
T18072 24527-24537 UMLS/C0282554 denotes emokines a
T18071 23981-23991 UMLS/C0282554 denotes emokines,
T18070 24899-24909 UMLS/C1705419 denotes perties an
T18069 22695-22705 UMLS/C1705419 denotes operties.
T18068 22071-22081 UMLS/C1705419 denotes properties
T18067 24146-24167 UP/Q8JFG3 denotes mor necrosis factor-s
T18066 22491-22499 UMLS/C1550315 denotes novial i
T18065 24146-24167 UP/P59695 denotes mor necrosis factor-s
T18064 24146-24167 UP/Q06599 denotes mor necrosis factor-s
T18063 26694-26700 UMLS/C0016884 denotes riment
T18062 24146-24167 UP/O35734 denotes mor necrosis factor-s
T18061 27794-27801 UMLS/C0243122 denotes in the
T18060 26476-26483 UMLS/C0243122 denotes tivity
T18059 26671-26676 UMLS/C0027552 denotes stud
T18058 25256-25265 UMLS/C0026473 denotes cytes/mac
T18057 24359-24364 UMLS/C1881122 denotes -23)
T18056 23654-23659 UMLS/C1881122 denotes -23 t
T18055 26012-26017 UMLS/C0243095 denotes that
T18054 23318-23323 UMLS/C0243095 denotes und,
T18053 22848-22853 UMLS/C0243095 denotes und t
T18052 26397-26405 UMLS/C0443289 denotes that p38
T18050 24146-24167 UP/P29553 denotes mor necrosis factor-s
T18049 23684-23688 UMLS/C0439208 denotes am-n
T18048 28078-28086 UMLS/C1521840 denotes es in RA
T18047 24146-24167 UP/P13296 denotes mor necrosis factor-s
T18046 24278-24284 UMLS/C1521826 denotes ents t
T18045 22965-22971 UMLS/C1521826 denotes ents t
T18044 24899-24909 UMLS/C1882134 denotes perties an
T18043 22695-22705 UMLS/C1882134 denotes operties.
T18042 22071-22081 UMLS/C1882134 denotes properties
T18041 23868-23875 UMLS/C1704241 denotes mplex i
T18040 26415-26430 UMLS/C1155551 denotes vation was not
T18039 23349-23354 UMLS/C0005507 denotes say (
T18038 26571-26582 UMLS/C1608386 denotes t of PI3K a
T18037 26834-26838 UMLS/C1517945 denotes ivit
T18036 25312-25318 UMLS/C0439166 denotes al ind
T18035 27212-27216 UMLS/C1321301 denotes rast
T18034 25849-25853 UMLS/C1321301 denotes was
T18033 25784-25788 UMLS/C1321301 denotes . We
T18032 25419-25423 UMLS/C1321301 denotes . Al
T18031 25281-25285 UMLS/C1321301 denotes cul
T18030 25073-25077 UMLS/C1321301 denotes C, b
T18029 24743-24747 UMLS/C1321301 denotes MC.
T18028 24485-24489 UMLS/C1321301 denotes MC r
T18027 23282-23286 UMLS/C1321301 denotes MC i
T18026 22784-22788 UMLS/C1321301 denotes MC,
T18025 27887-27897 UMLS/C0439167 denotes uccessful
T18024 27802-27810 UMLS/C0439167 denotes IL-17 pr
T18023 26842-26850 UMLS/C0439167 denotes 2 hours
T18022 26484-26492 UMLS/C0439167 denotes as decre
T18021 23440-23448 UMLS/C0439167 denotes tivity r
T18020 27146-27153 UMLS/C1704259 denotes so acti
T18019 26742-26749 UMLS/C1704259 denotes PI3K se
T18018 26563-26570 UMLS/C1704259 denotes depende
T17869 23119-23130 UMLS/C1550471 denotes dividuals [
T17868 25772-25777 UMLS/C0384648 denotes 7 in
T17867 25501-25506 UMLS/C0384648 denotes 7 has
T17866 25397-25402 UMLS/C0384648 denotes 7 ind
T17865 24731-24736 UMLS/C0384648 denotes -17 i
T17864 24473-24478 UMLS/C0384648 denotes -17 i
T17863 26854-26861 UMLS/C1292425 denotes e fact
T17862 26170-26178 UMLS/C1317973 denotes rts cros
T17861 24053-24058 UMLS/C0384648 denotes -17 s
T17860 24197-24213 UMLS/C0012472 denotes ostaglandin E2 i
T17859 24146-24167 UP/Q2MH05 denotes mor necrosis factor-s
T17858 23896-23901 UMLS/C1948049 denotes lls i
T17857 23563-23568 UMLS/C1948049 denotes lls,
T17856 25927-25936 UMLS/C1999216 denotes itor PDTC
T17855 25893-25902 UMLS/C1999216 denotes bitor LY2
T17854 22396-22402 UMLS/C1511790 denotes tect i
T17853 23488-23493 UMLS/C0384648 denotes -17 i
T17852 24146-24167 UP/Q539C2 denotes mor necrosis factor-s
T17851 26389-26396 UMLS/C1280519 denotes evealed
T17850 27954-27963 UMLS/C0003864 denotes mal model
T17849 25200-25207 UMLS/C1280500 denotes cts ind
T17848 22555-22562 UMLS/C1549479 denotes mited i
T17847 23698-23717 UMLS/C0876973 denotes lmonary infection [
T17846 27235-27239 UMLS/C0162508 denotes rans
T17845 26635-26638 UMLS/C1833235 denotes -κB
T17844 23399-23404 UMLS/C0384648 denotes -17 m
T17843 26285-26288 UMLS/C1833235 denotes sti
T17842 26257-26260 UMLS/C1833235 denotes , a
T17841 26208-26211 UMLS/C1833235 denotes n m
T17840 26439-26447 UMLS/C0001721 denotes by LY294
T17839 24952-24958 UMLS/C0001721 denotes ect IL
T17838 27235-27239 UMLS/C1333571 denotes rans
T17837 22837-22842 UMLS/C0384648 denotes -17 w
T17836 22596-22601 UMLS/C0384648 denotes -17 i
T17835 22004-22009 UMLS/C0384648 denotes IL-17
T17834 27171-27179 UMLS/C1314939 denotes he induc
T17833 26947-26958 UMLS/C1314939 denotes of PI3K in
T17832 26439-26447 UMLS/C1314939 denotes by LY294
T17831 26325-26334 UMLS/C1314939 denotes histone
T17830 25743-25751 UMLS/C1314939 denotes lved in
T17829 24952-24958 UMLS/C1314939 denotes ect IL
T17828 27433-27444 UMLS/C0004083 denotes ith NF-κB h
T17827 27887-27897 UMLS/C1561536 denotes uccessful
T17826 27802-27810 UMLS/C1561536 denotes IL-17 pr
T17825 26842-26850 UMLS/C1561536 denotes 2 hours
T17824 26484-26492 UMLS/C1561536 denotes as decre
T17823 23440-23448 UMLS/C1561536 denotes tivity r
T17822 26718-26724 UMLS/C1552603 denotes a down
T17821 23896-23901 UMLS/C1704653 denotes lls i
T17820 23563-23568 UMLS/C1704653 denotes lls,
T17819 27775-27783 UMLS/C0332206 denotes κB bindi
T17818 24081-24093 UMLS/C0224522 denotes noviocytes t
T17817 26607-26613 UMLS/C1552596 denotes ations
T17816 24146-24167 UP/O77510 denotes mor necrosis factor-s
T17815 24146-24167 UP/Q75N23 denotes mor necrosis factor-s
T17814 24936-24942 UMLS/C0392905 denotes nts, d
T17813 24032-24038 UMLS/C0392905 denotes ints.
T17812 23917-23923 UMLS/C0392905 denotes ints m
T17811 25464-25486 UMLS/C1621633 denotes ction of cytokines/che
T17810 24936-24942 UMLS/C1269611 denotes nts, d
T17809 24032-24038 UMLS/C1269611 denotes ints.
T17808 23917-23923 UMLS/C1269611 denotes ints m
T17807 27762-27774 UMLS/C0521115 denotes ocking of NF
T17806 24013-24024 UMLS/C1979779 denotes her cells i
T17805 26783-26791 UMLS/C1704632 denotes Akt act
T17804 27433-27444 UMLS/C0596306 denotes ith NF-κB h
T17803 28018-28035 UMLS/C0086982 denotes y is an important
T17802 27287-27304 UMLS/C0086982 denotes hway for cytokine
T17801 27240-27267 UMLS/C0086982 denotes uction pathway, another imp
T17800 25714-25731 UMLS/C0086982 denotes aling pathway was
T17799 25625-25643 UMLS/C0086982 denotes aling pathways. By
T17798 25438-25455 UMLS/C0086982 denotes aling pathway for
T17797 22800-22817 UMLS/C0086982 denotes gnaling pathway i
T17796 23868-23875 UMLS/C0439855 denotes mplex i
T17795 25009-25015 UMLS/C0332185 denotes ent re
T17794 23689-23697 UMLS/C1513916 denotes gative p
T17793 27794-27801 UMLS/C1167622 denotes in the
T17792 26476-26483 UMLS/C1167622 denotes tivity
T17791 23689-23697 UMLS/C0205160 denotes gative p
T17790 22464-22476 UMLS/C1293122 denotes gmentation o
T17789 27171-27179 UMLS/C1947935 denotes he induc
T17788 26325-26334 UMLS/C1947935 denotes histone
T17787 25743-25751 UMLS/C1947935 denotes lved in
T17786 24814-24818 UMLS/C0205172 denotes re m
T17785 26607-26613 UMLS/C0439851 denotes ations
T17784 26607-26613 UMLS/C1947931 denotes ations
T17783 25149-25157 UMLS/C1947931 denotes ctly ind
T17782 28012-28017 UMLS/C1623218 denotes pathw
T17781 27818-27823 UMLS/C1623218 denotes y PDT
T17780 27709-27714 UMLS/C1623218 denotes the
T17779 27558-27563 UMLS/C1623218 denotes ing.
T17778 27200-27205 UMLS/C1623218 denotes BMC.
T17777 26987-26992 UMLS/C1623218 denotes . In
T17776 25772-25777 UMLS/C1623218 denotes 7 in
T17775 25501-25506 UMLS/C1623218 denotes 7 has
T17774 25397-25402 UMLS/C1623218 denotes 7 ind
T17773 24731-24736 UMLS/C1623218 denotes -17 i
T17772 24473-24478 UMLS/C1623218 denotes -17 i
T17771 24053-24058 UMLS/C1623218 denotes -17 s
T17770 23488-23493 UMLS/C1623218 denotes -17 i
T17769 23399-23404 UMLS/C1623218 denotes -17 m
T17768 22837-22842 UMLS/C1623218 denotes -17 w
T17767 22596-22601 UMLS/C1623218 denotes -17 i
T17766 22004-22009 UMLS/C1623218 denotes IL-17
T17765 24668-24672 UMLS/C0205170 denotes ll a
T17764 24554-24558 UMLS/C0205170 denotes ll a
T17763 24189-24193 UMLS/C0205170 denotes ll a
T17762 23177-23181 UMLS/C0205170 denotes ll a
T17761 27433-27444 UMLS/C0439849 denotes ith NF-κB h
T17760 26614-26626 UMLS/C0439849 denotes ip between p
T17759 26635-26638 UP/O97628 denotes -κB
T17758 26285-26288 UP/O97628 denotes sti
T17757 26257-26260 UP/O97628 denotes , a
T17756 26208-26211 UP/O97628 denotes n m
T17755 24137-24141 UMLS/C1705592 denotes -8 a
T17754 22181-22198 UMLS/C0806987 denotes mononuclear cells
T17753 23896-23901 UMLS/C1269647 denotes lls i
T17752 23563-23568 UMLS/C1269647 denotes lls,
T17751 22555-22562 UMLS/C0205189 denotes mited i
T17750 24359-24364 UMLS/C0963088 denotes -23)
T17749 23654-23659 UMLS/C0963088 denotes -23 t
T17748 26826-26833 UMLS/C0439833 denotes s of ac
T17747 26938-26946 UMLS/C0332149 denotes volvemen
T17746 27123-27129 UMLS/C0332148 denotes the NF
T17745 27994-28007 UMLS/C0162340 denotes e IL-17 signa
T17744 26497-26506 UMLS/C0392756 denotes by LY2940
T17743 26925-26933 UMLS/C1705535 denotes e possib
T17742 25312-25318 UMLS/C1704701 denotes al ind
T17741 27083-27091 UMLS/C0018284 denotes our expe
T17740 24542-24550 UMLS/C0018284 denotes togens a
T17739 23164-23172 UMLS/C0018284 denotes togens,
T17738 26439-26447 UMLS/C0392760 denotes by LY294
T17737 24952-24958 UMLS/C0392760 denotes ect IL
T17736 25699-25707 UMLS/C0332128 denotes ined whi
T17735 22605-22614 UMLS/C0680651 denotes pealing b
T17734 27467-27475 UMLS/C1709908 denotes liver ac
T17733 25299-25307 UMLS/C1709908 denotes rted for
T17732 25016-25022 UMLS/C1709908 denotes ort th
T17731 25312-25318 UMLS/C1550457 denotes al ind
T17730 22165-22177 UMLS/C0702249 denotes infiltration
T17729 26161-26169 UMLS/C0332120 denotes nce supp
T17728 24774-24777 UMLS/C0034790 denotes R l
T17727 24676-24679 UMLS/C0034790 denotes R l
T17726 24579-24582 UMLS/C0034790 denotes R)
T17725 24562-24577 UMLS/C0034790 denotes cell receptor (
T17724 23230-23245 UMLS/C0034790 denotes cell receptor,
T17723 27824-27832 UMLS/C0086860 denotes and LY2
T17722 23905-23913 UMLS/C0333348 denotes flamed R
T17721 26635-26638 UP/Q64010 denotes -κB
T17720 26285-26288 UP/Q64010 denotes sti
T17719 26257-26260 UP/Q64010 denotes , a
T17718 26208-26211 UP/Q64010 denotes n m
T17717 25516-25526 UMLS/C1563337 denotes mented wid
T17716 27902-27912 UMLS/C1272703 denotes tion of an
T17715 24146-24167 UP/P51742 denotes mor necrosis factor-s
T17714 27235-27239 UMLS/C0812312 denotes rans
T17713 22128-22149 UMLS/C0808143 denotes synovial lining cells
T17712 25094-25100 UMLS/C1272696 denotes do so
T17711 24819-24827 UMLS/C0522501 denotes rkedly.
T17710 23582-23591 UMLS/C1314763 denotes enotype [
T17709 25966-25971 UMLS/C0205112 denotes prod
T17708 27408-27418 UMLS/C0522506 denotes nase Akt i
T17707 26731-26741 UMLS/C0522506 denotes pathway of
T17706 27419-27425 UMLS/C0031727 denotes assoc
T17705 25312-25318 UMLS/C1551394 denotes al ind
T17704 22157-22164 UMLS/C0522510 denotes intense
T17703 23876-23887 UMLS/C1704675 denotes teraction b
T17702 26783-26791 UMLS/C0871261 denotes Akt act
T17701 25793-25803 UMLS/C1551388 denotes tified tha
T17700 27221-27229 UMLS/C1979874 denotes AP-1 si
T17699 24832-24840 UMLS/C1979874 denotes ntrast,
T17698 25034-25043 UMLS/C1444748 denotes ggered in
T17697 23660-23670 UMLS/C1444748 denotes iggering m
T17695 28012-28017 UMLS/C1825592 denotes pathw
T17694 27818-27823 UMLS/C1825592 denotes y PDT
T17693 27709-27714 UMLS/C1825592 denotes the
T17692 27558-27563 UMLS/C1825592 denotes ing.
T17691 27200-27205 UMLS/C1825592 denotes BMC.
T17690 26987-26992 UMLS/C1825592 denotes . In
T17689 25772-25777 UMLS/C1825592 denotes 7 in
T17688 25501-25506 UMLS/C1825592 denotes 7 has
T17687 25397-25402 UMLS/C1825592 denotes 7 ind
T17686 24731-24736 UMLS/C1825592 denotes -17 i
T17685 24473-24478 UMLS/C1825592 denotes -17 i
T17684 24053-24058 UMLS/C1825592 denotes -17 s
T17683 23488-23493 UMLS/C1825592 denotes -17 i
T17682 23399-23404 UMLS/C1825592 denotes -17 m
T17681 22837-22842 UMLS/C1825592 denotes -17 w
T17680 22596-22601 UMLS/C1825592 denotes -17 i
T17679 22004-22009 UMLS/C1825592 denotes IL-17
T17678 22383-22392 UMLS/C0332218 denotes fficult t
T17677 28074-28077 UMLS/C0205314 denotes rap
T17676 23024-23031 UMLS/C1299351 denotes ghest l
T17675 22860-22866 UMLS/C1299351 denotes gher i
T17674 24869-24874 UMLS/C0205309 denotes wn to
T17673 24376-24381 UMLS/C0205309 denotes own t
T17672 28052-28059 UMLS/C0013879 denotes oping n
T17671 25312-25318 UMLS/C0205307 denotes al ind
T17670 27967-27980 UMLS/C0599779 denotes ,6,34-36], un
T17669 27568-27575 UMLS/C0332268 denotes ata cle
T17668 22518-22522 UMLS/C0332268 denotes ck o
T17667 25188-25193 UMLS/C0337876 denotes t exe
T17666 23924-23929 UMLS/C0337876 denotes ght p
T17665 23405-23410 UMLS/C0337876 denotes ght b
T17664 22441-22444 UMLS/C0337876 denotes y h
T17663 23854-23859 UMLS/C0870071 denotes del [
T17662 25047-25052 UMLS/C0021135 denotes ro IL
T17661 24453-24458 UMLS/C0021135 denotes tro p
T17660 24217-24222 UMLS/C0021135 denotes tro [
T17659 24146-24167 UP/P51435 denotes mor necrosis factor-s
T17658 26775-26782 UMLS/C0205289 denotes ponse o
T17657 26389-26396 UMLS/C1546471 denotes evealed
T17656 22657-22664 UMLS/C1441547 denotes rived c
T17655 22533-22540 UMLS/C1441547 denotes rived c
T17654 22311-22318 UMLS/C1441547 denotes erived
T17579 26358-26378 UP/P45481 denotes ing protein [33]. Ou
T17578 26151-26157 UMLS/C2348044 denotes s of e
T17577 27467-27475 UMLS/C0700287 denotes liver ac
T17576 25299-25307 UMLS/C0700287 denotes rted for
T17575 25016-25022 UMLS/C0700287 denotes ort th
T17574 26497-26506 UMLS/C0205216 denotes by LY2940
T17573 25387-25396 UMLS/C0205217 denotes eases IL-
T17572 24920-24929 UMLS/C0205217 denotes reased in
T17571 24787-24796 UMLS/C0205217 denotes gmented I
T17570 24703-24712 UMLS/C0205217 denotes creased t
T17569 23772-23781 UMLS/C0205217 denotes gmented b
T17568 23421-23430 UMLS/C0205217 denotes creased c
T17567 23247-23256 UMLS/C0205217 denotes creased I
T17566 26683-26690 UMLS/C1705923 denotes future
T17565 24623-24630 UMLS/C1705923 denotes udies d
T17564 22714-22721 UMLS/C1705923 denotes udies,
T17563 26938-26946 UMLS/C2362652 denotes volvemen
T17562 23827-23853 UMLS/C0971858 denotes llagen-induced arthritis m
T17561 24359-24364 UMLS/C1423526 denotes -23)
T17560 23654-23659 UMLS/C1423526 denotes -23 t
T17559 26132-26143 UMLS/C0543488 denotes esting that
T17558 24146-24167 UP/P59694 denotes mor necrosis factor-s
T17557 24899-24909 UMLS/C0871161 denotes perties an
T17556 22695-22705 UMLS/C0871161 denotes operties.
T17555 22071-22081 UMLS/C0871161 denotes properties
T17554 24146-24167 UP/P33620 denotes mor necrosis factor-s
T17553 27581-27585 UMLS/C1511726 denotes emon
T17552 27530-27534 UMLS/C1511726 denotes gnal
T17551 27369-27373 UMLS/C1511726 denotes n).
T17550 24981-24985 UMLS/C1511726 denotes a we
T17549 24256-24260 UMLS/C1511726 denotes ta a
T17548 23356-23360 UMLS/C1511726 denotes ta n
T17547 22943-22947 UMLS/C1511726 denotes ta a
T17546 26783-26791 UMLS/C1706817 denotes Akt act
T17545 26571-26582 UMLS/C1549571 denotes t of PI3K a
T17544 22500-22512 UMLS/C0021368 denotes flammation,
T17543 27479-27486 UMLS/C1705822 denotes ting si
T17542 27653-27658 UMLS/C0006823 denotes ortan
T17541 26289-26292 UMLS/C0006823 denotes ula
T17540 25597-25600 UMLS/C0006823 denotes be
T17539 23610-23613 UMLS/C0006823 denotes n a
T17538 23058-23061 UMLS/C0006823 denotes n b
T17537 22014-22019 UMLS/C0205435 denotes first
T17536 25047-25052 UMLS/C1533691 denotes ro IL
T17535 24453-24458 UMLS/C1533691 denotes tro p
T17534 24217-24222 UMLS/C1533691 denotes tro [
T17533 27235-27239 UP/P21525 denotes rans
T17532 26635-26638 UP/Q04929 denotes -κB
T17531 26285-26288 UP/Q04929 denotes sti
T18017 24146-24167 UP/P36939 denotes mor necrosis factor-s
T18016 23464-23486 UMLS/C0020507 denotes llular proliferation.
T18015 22113-22124 UMLS/C0020507 denotes hyperplasia
T18014 23805-23821 UMLS/C0009331 denotes pe II collagen i
T18013 26854-26861 UMLS/C1547059 denotes e fact
T18012 26012-26017 UMLS/C0037088 denotes that
T18011 23318-23323 UMLS/C0037088 denotes und,
T18010 22848-22853 UMLS/C0037088 denotes und t
T18009 24137-24141 UMLS/C0079633 denotes -8 a
T18008 22014-22019 UMLS/C1279901 denotes first
T18007 27653-27658 UMLS/C0344312 denotes ortan
T18006 26289-26292 UMLS/C0344312 denotes ula
T18005 25597-25600 UMLS/C0344312 denotes be
T18004 23610-23613 UMLS/C0344312 denotes n a
T18003 23058-23061 UMLS/C0344312 denotes n b
T18002 23582-23591 UMLS/C1285572 denotes enotype [
T18001 25516-25526 UMLS/C1301746 denotes mented wid
T18000 28018-28035 UMLS/C0037080 denotes y is an important
T17999 27287-27304 UMLS/C0037080 denotes hway for cytokine
T17998 25714-25731 UMLS/C0037080 denotes aling pathway was
T17997 25625-25643 UMLS/C0037080 denotes aling pathways. By
T17996 25438-25455 UMLS/C0037080 denotes aling pathway for
T17995 22800-22817 UMLS/C0037080 denotes gnaling pathway i
T17994 27542-27548 UMLS/C0037083 denotes g IL-1
T17993 27498-27505 UMLS/C0037083 denotes y cell
T17992 23208-23217 UMLS/C0037083 denotes gnaling t
T17991 26358-26378 UMLS/C0256079 denotes ing protein [33]. Ou
T17990 26094-26102 UMLS/C0297666 denotes 580, a p
T17989 24936-24942 UMLS/C1706309 denotes nts, d
T17988 24032-24038 UMLS/C1706309 denotes ints.
T17987 23917-23923 UMLS/C1706309 denotes ints m
T17986 23684-23688 UMLS/C0331538 denotes am-n
T17985 27612-27616 UMLS/C1705325 denotes esul
T17984 27395-27399 UMLS/C1705325 denotes down
T17983 26962-26966 UMLS/C1705325 denotes ind
T17982 26753-26757 UMLS/C1705325 denotes to
T17981 26586-26590 UMLS/C1705325 denotes atio
T17980 25888-25892 UMLS/C1705325 denotes inh
T17979 27003-27007 UMLS/C0449911 denotes fac
T17978 26614-26626 UMLS/C1706279 denotes ip between p
T17977 22452-22456 UMLS/C1704326 denotes le i
T17976 24490-24503 UMLS/C1553423 denotes sponding to a
T17975 22899-22913 UMLS/C0039097 denotes novial fluid [
T17974 22873-22887 UMLS/C0039097 denotes novial fluid t
T17973 22409-22417 UMLS/C0039099 denotes novium [
T17972 22282-22290 UMLS/C0039099 denotes ynovium,
T17971 25312-25318 UMLS/C1873497 denotes al ind
T17970 27509-27513 UMLS/C0439064 denotes s, t
T17969 24814-24818 UMLS/C0439064 denotes re m
T17968 27319-27329 UMLS/C1527036 denotes as not act
T17967 25487-25497 UMLS/C1527036 denotes okines by
T17966 24527-24537 UMLS/C1527036 denotes emokines a
T17965 23981-23991 UMLS/C1527036 denotes emokines,
T17964 22042-22049 UMLS/C1704444 denotes product
T17963 27742-27753 UMLS/C1706386 denotes wing simult
T17962 27356-27367 UMLS/C1706386 denotes data not sh
T17961 27099-27110 UMLS/C1706386 denotes it is most
T17960 26701-26712 UMLS/C1706386 denotes . The searc
T17959 23144-23155 UMLS/C1706386 denotes periments,
T17958 22096-22109 UMLS/C1880022 denotes characterized
T17957 25507-25510 UMLS/C2348947 denotes bee
T17956 22626-22629 UMLS/C2348947 denotes s b
T17955 22551-22554 UMLS/C2348947 denotes s l
T17954 28074-28077 UMLS/C1553390 denotes rap
T17953 24774-24777 UMLS/C1167203 denotes R l
T17952 24676-24679 UMLS/C1167203 denotes R l
T17951 24579-24582 UMLS/C1167203 denotes R)
T17950 24137-24141 UMLS/C1366571 denotes -8 a
T17949 25222-25229 UMLS/C0039194 denotes lls thr
T17948 23785-23792 UMLS/C0039194 denotes cells r
T17947 23639-23646 UMLS/C0039194 denotes cells v
T17946 23531-23538 UMLS/C0039194 denotes cells,
T17945 22650-22656 UMLS/C0039194 denotes cell-d
T17944 22526-22532 UMLS/C0039194 denotes cell-d
T17943 22433-22440 UMLS/C0039194 denotes cells m
T17942 22304-22310 UMLS/C0039194 denotes cell-
T17941 22035-22041 UMLS/C0039194 denotes T cell
T17940 26913-26924 UMLS/C1948023 denotes suggests t
T17939 26293-26302 UMLS/C1948023 denotes e NF-κB b
T17938 25991-26002 UMLS/C1948023 denotes lation. We
T17937 24290-24299 UMLS/C1948023 denotes imulate I
T17936 24168-24178 UMLS/C1948023 denotes imulated g
T17935 24059-24069 UMLS/C1948023 denotes imulates r
T17934 23096-23107 UMLS/C1948023 denotes imulation i
T17933 22977-22986 UMLS/C1948023 denotes imulate I
T17932 25516-25526 UMLS/C1548385 denotes mented wid
T17931 25286-25294 UMLS/C2242979 denotes ures. As
T17930 26683-26690 UMLS/C2603343 denotes future
T17929 24623-24630 UMLS/C2603343 denotes udies d
T17928 22714-22721 UMLS/C2603343 denotes udies,
T17927 25256-25265 UMLS/C0200637 denotes cytes/mac
T17926 26497-26506 UMLS/C0547047 denotes by LY2940
T17925 26635-26638 UMLS/C1705633 denotes -κB
T17924 26285-26288 UMLS/C1705633 denotes sti
T17923 24097-24104 UMLS/C1327616 denotes crete s
T17922 26257-26260 UMLS/C1705633 denotes , a
T17921 24899-24909 UMLS/C1704391 denotes perties an
T17920 22695-22705 UMLS/C1704391 denotes operties.
T17919 22071-22081 UMLS/C1704391 denotes properties
T17918 26208-26211 UMLS/C1705633 denotes n m
T17917 26614-26626 UMLS/C1705630 denotes ip between p
T17916 27612-27616 UP/P42336 denotes esul
T17915 27395-27399 UP/P42336 denotes down
T17914 26962-26966 UP/P42336 denotes ind
T17913 26753-26757 UP/P42336 denotes to
T17912 26586-26590 UP/P42336 denotes atio
T17911 25888-25892 UP/P42336 denotes inh
T17910 26683-26690 UMLS/C2349977 denotes future
T17909 24623-24630 UMLS/C2349977 denotes udies d
T17908 22714-22721 UMLS/C2349977 denotes udies,
T17907 23464-23486 UMLS/C0596290 denotes llular proliferation.
T17906 23330-23348 UMLS/C0596290 denotes ll proliferation a
T17905 25286-25294 UMLS/C0430400 denotes ures. As
T17904 26571-26582 UMLS/C1299583 denotes t of PI3K a
T17903 25094-25100 UMLS/C1879934 denotes do so
T17902 28012-28017 UMLS/C0384648 denotes pathw
T17901 27818-27823 UMLS/C0384648 denotes y PDT
T17900 27709-27714 UMLS/C0384648 denotes the
T17899 27558-27563 UMLS/C0384648 denotes ing.
T17898 27200-27205 UMLS/C0384648 denotes BMC.
T17897 26315-26324 UMLS/C1706376 denotes involvin
T17896 23671-23680 UMLS/C1706376 denotes chanism i
T17895 26635-26638 UMLS/C1412886 denotes -κB
T17894 26285-26288 UMLS/C1412886 denotes sti
T17893 26257-26260 UMLS/C1412886 denotes , a
T17892 26208-26211 UMLS/C1412886 denotes n m
T17891 24936-24942 UMLS/C0022417 denotes nts, d
T17890 24032-24038 UMLS/C0022417 denotes ints.
T17889 23917-23923 UMLS/C0022417 denotes ints m
T17888 28052-28059 UMLS/C1705248 denotes oping n
T17887 25516-25526 UMLS/C1301725 denotes mented wid
T17886 26335-26357 UMLS/C0390904 denotes cetylase p300/CREB-bin
T17885 26813-26819 UMLS/C1442450 denotes a grad
T17884 27235-27239 UMLS/C0087140 denotes rans
T17883 22042-22049 UMLS/C1550506 denotes product
T17882 25286-25294 UMLS/C0220814 denotes ures. As
T17881 23582-23591 UMLS/C0031437 denotes enotype [
T17880 22735-22743 UMLS/C0220825 denotes aluate h
T17879 23647-23650 UMLS/C1550513 denotes a a
T17878 26987-26992 UMLS/C0384648 denotes . In
T17877 25188-25193 UMLS/C0454788 denotes t exe
T17876 23924-23929 UMLS/C0454788 denotes ght p
T17875 23405-23410 UMLS/C0454788 denotes ght b
T17874 22441-22444 UMLS/C0454788 denotes y h
T17873 23896-23901 UMLS/C1136359 denotes lls i
T17872 23563-23568 UMLS/C1136359 denotes lls,
T17871 25200-25207 UMLS/C2348382 denotes cts ind
T17870 25319-25330 UMLS/C1550471 denotes viduals [25
T17530 26257-26260 UP/Q04929 denotes , a
T17529 26208-26211 UP/Q04929 denotes n m
T17528 25266-25277 UMLS/C1550652 denotes ophages in
T17527 24146-24167 UP/P23383 denotes mor necrosis factor-s
T17526 26947-26958 UMLS/C0205428 denotes of PI3K in
T17525 24506-24513 UMLS/C2346866 denotes riety o
T17524 23940-23947 UMLS/C2346866 denotes riety o
T17523 24146-24167 UP/Q1G1A2 denotes mor necrosis factor-s
T17522 26315-26324 UMLS/C0441712 denotes involvin
T17521 23671-23680 UMLS/C0441712 denotes chanism i
T17520 22165-22177 UMLS/C0332448 denotes infiltration
T17519 26358-26378 UP/Q92793 denotes ing protein [33]. Ou
T17518 25617-25624 UMLS/C0205423 denotes ain sig
T17517 23024-23031 UMLS/C1522410 denotes ghest l
T17516 22860-22866 UMLS/C1522410 denotes gher i
T17515 25793-25803 UMLS/C0205396 denotes tified tha
T17514 27794-27801 UMLS/C1689898 denotes in the
T17513 26476-26483 UMLS/C1689898 denotes tivity
T17512 24146-24167 UP/Q8WNR1 denotes mor necrosis factor-s
T17511 25516-25526 UMLS/C1547673 denotes mented wid
T17510 22555-22562 UMLS/C1549649 denotes mited i
T17509 27887-27897 UMLS/C0441655 denotes uccessful
T17508 27802-27810 UMLS/C0441655 denotes IL-17 pr
T17507 26842-26850 UMLS/C0441655 denotes 2 hours
T17506 26484-26492 UMLS/C0441655 denotes as decre
T17505 23440-23448 UMLS/C0441655 denotes tivity r
T17504 24146-24167 UMLS/C1456820 denotes mor necrosis factor-s
T17503 24146-24167 UP/Q9BEA1 denotes mor necrosis factor-s
T17502 24146-24167 UP/Q19LH4 denotes mor necrosis factor-s
T17501 24252-24255 UMLS/C0205388 denotes w d
T17500 22939-22942 UMLS/C0205388 denotes w d
T17499 22555-22562 UMLS/C0449295 denotes mited i
T17498 27617-27620 UP/Q8INB9 denotes ant
T17497 27426-27429 UP/Q8INB9 denotes ati
T17496 26877-26880 UP/Q8INB9 denotes pho
T17495 26795-26798 UP/Q8INB9 denotes ion
T17494 27235-27239 UP/A8MPH9 denotes rans
T17493 26497-26506 UMLS/C0442797 denotes by LY2940
T17492 26082-26090 UMLS/C1883712 denotes ion of S
T17491 24749-24755 UMLS/C1883712 denotes ding I
T17490 23727-23735 UMLS/C1883712 denotes dition,
T17489 25387-25396 UMLS/C0442805 denotes eases IL-
T17488 24920-24929 UMLS/C0442805 denotes reased in
T17487 24703-24712 UMLS/C0442805 denotes creased t
T17486 23421-23430 UMLS/C0442805 denotes creased c
T17485 23247-23256 UMLS/C0442805 denotes creased I
T17484 26683-26690 UMLS/C0557651 denotes future
T17483 24623-24630 UMLS/C0557651 denotes udies d
T17482 22714-22721 UMLS/C0557651 denotes udies,
T17481 24044-24051 UMLS/C1707959 denotes ample,
T17480 25387-25396 UMLS/C0442808 denotes eases IL-
T17479 24920-24929 UMLS/C0442808 denotes reased in
T17478 24703-24712 UMLS/C0442808 denotes creased t
T17477 23421-23430 UMLS/C0442808 denotes creased c
T17476 23247-23256 UMLS/C0442808 denotes creased I
T17475 22452-22456 UMLS/C1705809 denotes le i
T17474 22452-22456 UMLS/C1705812 denotes le i
T17473 22464-22476 UMLS/C0332509 denotes gmentation o
T17472 22452-22456 UMLS/C1705810 denotes le i
T17471 22452-22456 UMLS/C1705811 denotes le i
T17470 24842-24846 UMLS/C1522428 denotes -1 a
T17469 22239-22243 UMLS/C1522428 denotes IL-1
T17468 26170-26178 UMLS/C0183683 denotes rts cros
T17467 25956-25962 UMLS/C0456079 denotes s of b
T17466 23032-23037 UMLS/C0456079 denotes vel o
T17465 22827-22833 UMLS/C0456079 denotes vels o
T17464 24146-24167 UP/P06804 denotes mor necrosis factor-s
T17463 24278-24284 UMLS/C1254351 denotes ents t
T17462 22965-22971 UMLS/C1254351 denotes ents t
T17461 24842-24846 UMLS/C1149212 denotes -1 a
T17460 22239-22243 UMLS/C1149212 denotes IL-1
T17459 25516-25526 UMLS/C1609436 denotes mented wid
T17458 26635-26638 UP/P46108 denotes -κB
T17457 26285-26288 UP/P46108 denotes sti
T17456 26257-26260 UP/P46108 denotes , a
T17455 26208-26211 UP/P46108 denotes n m
T17454 27074-27079 UMLS/C1149222 denotes ogens
T17453 25028-25033 UMLS/C1149222 denotes 15 tr
T17452 24756-24761 UMLS/C1149222 denotes -15 o
T17451 24649-24654 UMLS/C1149222 denotes -15 a
T17450 24349-24354 UMLS/C1149222 denotes -15 a
T17449 23157-23160 UMLS/C0030779 denotes A a
T17448 24146-24167 UP/Q1WM27 denotes mor necrosis factor-s
T17447 22452-22456 UMLS/C0035820 denotes le i
T17446 25956-25962 UMLS/C0441889 denotes s of b
T17445 23032-23037 UMLS/C0441889 denotes vel o
T17444 22827-22833 UMLS/C0441889 denotes vels o
T17443 24359-24364 UMLS/C1149233 denotes -23)
T17442 23654-23659 UMLS/C1149233 denotes -23 t
T17441 24433-24445 UMLS/C1292732 denotes vestigated t
T17440 27074-27079 UMLS/C0254610 denotes ogens
T17439 25028-25033 UMLS/C0254610 denotes 15 tr
T17438 24756-24761 UMLS/C0254610 denotes -15 o
T17437 24649-24654 UMLS/C0254610 denotes -15 a
T17436 24349-24354 UMLS/C0254610 denotes -15 a
T17435 22341-22345 UMLS/C1149239 denotes L-4
T17434 24131-24135 UMLS/C1149241 denotes -6,
T17433 23349-23354 UMLS/C1510438 denotes say (
T17432 24146-24167 UMLS/C2700093 denotes mor necrosis factor-s
T17431 22657-22664 UMLS/C1711343 denotes rived c
T17430 22533-22540 UMLS/C1711343 denotes rived c
T17429 22311-22318 UMLS/C1711343 denotes erived
T17428 27762-27774 UMLS/C1548968 denotes ocking of NF
T17427 24146-24167 UMLS/C0041368 denotes mor necrosis factor-s
T17426 27642-27652 UMLS/C1879547 denotes d be an im
T17425 27487-27497 UMLS/C1879547 denotes nals in ma
T17424 27339-27348 UMLS/C1879547 denotes our exper
T17423 27041-27050 UMLS/C1879547 denotes anti-CD3
T17422 26799-26809 UMLS/C1879547 denotes at 1 hour
T17421 26591-26601 UMLS/C1879547 denotes . The dire
T17420 26275-26284 UMLS/C1879547 denotes d p38 can
T17419 26244-26253 UMLS/C1879547 denotes d by p38
T17418 25242-25252 UMLS/C1879547 denotes vation of
T17417 24004-24012 UMLS/C1879547 denotes tivate o
T17416 23516-23525 UMLS/C1879547 denotes tivated C
T17415 26216-26224 UMLS/C0596981 denotes es, IκB
T17414 26683-26690 UMLS/C0008972 denotes future
T17413 24623-24630 UMLS/C0008972 denotes udies d
T17412 22714-22721 UMLS/C0008972 denotes udies,
T17411 27433-27444 UMLS/C0699792 denotes ith NF-κB h
T17410 26683-26690 UMLS/C0008976 denotes future
T17409 24623-24630 UMLS/C0008976 denotes udies d
T17408 22714-22721 UMLS/C0008976 denotes udies,
T17407 27074-27079 UMLS/C1334105 denotes ogens
T17406 25028-25033 UMLS/C1334105 denotes 15 tr
T17405 24756-24761 UMLS/C1334105 denotes -15 o
T17404 24649-24654 UMLS/C1334105 denotes -15 a
T17403 24349-24354 UMLS/C1334105 denotes -15 a
T17402 24749-24755 UMLS/C1524062 denotes ding I
T17401 25793-25803 UMLS/C1550043 denotes tified tha
T17400 24131-24135 UMLS/C1527132 denotes -6,
T17399 24991-25006 UMLS/C1524057 denotes sistent with a
T17398 23431-23439 UMLS/C0178539 denotes llular a
T17397 25563-25572 UMLS/C0470187 denotes lable on
T17396 24261-24270 UMLS/C0470187 denotes ailable o
T17395 22948-22957 UMLS/C0470187 denotes ailable o
T17394 22341-22345 UMLS/C1522540 denotes L-4
T17393 25266-25277 UMLS/C1546706 denotes ophages in
T17392 26151-26157 UMLS/C0205549 denotes s of e
T17391 24146-24167 UP/P04924 denotes mor necrosis factor-s
T17390 25143-25148 UMLS/C1522558 denotes 1 dir
T17389 24765-24770 UMLS/C1522558 denotes P-1 t
T17388 24659-24664 UMLS/C1522558 denotes P-1 a
T17387 24146-24167 UP/P01375 denotes mor necrosis factor-s
T17386 24137-24141 UMLS/C1149173 denotes -8 a
T17385 24146-24167 UP/P16599 denotes mor necrosis factor-s
T17384 27309-27318 UMLS/C1524094 denotes mokines,
T17383 24517-24526 UMLS/C1524094 denotes tokines/c
T17382 24338-24347 UMLS/C1524094 denotes tokines (
T17381 24113-24122 UMLS/C1524094 denotes tokines s
T17380 23967-23976 UMLS/C1524094 denotes tokines a
T17379 22665-22673 UMLS/C1524094 denotes tokine w
T17378 22541-22550 UMLS/C1524094 denotes tokines h
T17377 22319-22328 UMLS/C1524094 denotes ytokines,
T17376 22221-22230 UMLS/C1524094 denotes cytokines
T17375 22341-22345 UMLS/C0021758 denotes L-4
T17374 23024-23031 UMLS/C1561957 denotes ghest l
T17373 22860-22866 UMLS/C1561957 denotes gher i
T17372 23024-23031 UMLS/C1561958 denotes ghest l
T17371 22860-22866 UMLS/C1561958 denotes gher i
T17370 28074-28077 UMLS/C1578513 denotes rap
T17369 24131-24135 UMLS/C0021760 denotes -6,
T17368 27729-27734 UMLS/C1527178 denotes perim
T17367 27845-27853 UMLS/C0251991 denotes ering it
T17366 26510-26518 UMLS/C0251991 denotes which pr
T17365 26451-26459 UMLS/C0251991 denotes whereas
T17364 25903-25911 UMLS/C0251991 denotes 4002 and
T17354 24731-24736 UMLS/C1522571 denotes -17 i
T17353 24473-24478 UMLS/C1522571 denotes -17 i
T17352 24053-24058 UMLS/C1522571 denotes -17 s
T17351 23488-23493 UMLS/C1522571 denotes -17 i
T17350 23399-23404 UMLS/C1522571 denotes -17 m
T17349 22837-22842 UMLS/C1522571 denotes -17 w
T17348 22596-22601 UMLS/C1522571 denotes -17 i
T17347 22004-22009 UMLS/C1522571 denotes IL-17
T17346 26913-26924 UMLS/C1292856 denotes suggests t
T17345 25991-26002 UMLS/C1292856 denotes lation. We
T17344 23096-23107 UMLS/C1292856 denotes imulation i
T17343 24131-24135 UMLS/C1334122 denotes -6,
T17342 25143-25148 UMLS/C1705079 denotes 1 dir
T17341 24765-24770 UMLS/C1705079 denotes P-1 t
T17340 24659-24664 UMLS/C1705079 denotes P-1 a
T17339 24842-24846 UMLS/C0021755 denotes -1 a
T17338 22239-22243 UMLS/C0021755 denotes IL-1
T17337 24842-24846 UMLS/C0021753 denotes -1 a
T17336 22239-22243 UMLS/C0021753 denotes IL-1
T17335 22341-22345 UMLS/C1334119 denotes L-4
T17334 26718-26724 UMLS/C1706202 denotes a down
T17333 27836-27840 UMLS/C0084183 denotes 2. C
T17332 25937-25941 UMLS/C0084183 denotes to c
T17331 24146-24167 UP/P51743 denotes mor necrosis factor-s
T17330 24278-24284 UMLS/C0450442 denotes ents t
T17329 22965-22971 UMLS/C0450442 denotes ents t
T17328 27612-27616 UMLS/C1368105 denotes esul
T17327 27395-27399 UMLS/C1368105 denotes down
T17326 26962-26966 UMLS/C1368105 denotes ind
T17325 26753-26757 UMLS/C1368105 denotes to
T17324 26586-26590 UMLS/C1368105 denotes atio
T17323 25888-25892 UMLS/C1368105 denotes inh
T17322 23876-23887 UMLS/C0687133 denotes teraction b
T17321 27742-27753 UMLS/C0681814 denotes wing simult
T17320 27356-27367 UMLS/C0681814 denotes data not sh
T17319 27099-27110 UMLS/C0681814 denotes it is most
T17318 26701-26712 UMLS/C0681814 denotes . The searc
T17317 23144-23155 UMLS/C0681814 denotes periments,
T17316 27775-27783 UMLS/C1706084 denotes κB bindi
T17315 24146-24167 UMLS/C1323304 denotes mor necrosis factor-s
T17314 25337-25354 UMLS/C1155065 denotes ll activation thr
T17313 25166-25183 UMLS/C1155065 denotes ll activation, it
T17312 26358-26378 UMLS/C1337090 denotes ing protein [33]. Ou
T17311 25927-25936 UMLS/C0243077 denotes itor PDTC
T17310 25893-25902 UMLS/C0243077 denotes bitor LY2
T17309 23349-23354 UMLS/C0243073 denotes say (
T17308 25143-25148 UMLS/C1337092 denotes 1 dir
T17307 24765-24770 UMLS/C1337092 denotes P-1 t
T17306 24659-24664 UMLS/C1337092 denotes P-1 a
T17653 22555-22562 UMLS/C0439801 denotes mited i
T17652 27433-27444 UMLS/C1704771 denotes ith NF-κB h
T17651 27433-27444 UMLS/C1704770 denotes ith NF-κB h
T17650 25654-25684 UMLS/C1519313 denotes al transduction inhibitors, we
T17649 27514-27524 UMLS/C0449475 denotes e data on
T17648 24146-24167 UP/Q8MKG8 denotes mor necrosis factor-s
T17647 25286-25294 UMLS/C0010453 denotes ures. As
T17646 27146-27153 UMLS/C1705987 denotes so acti
T17645 26742-26749 UMLS/C1705987 denotes PI3K se
T17644 26563-26570 UMLS/C1705987 denotes depende
T17643 27612-27616 UMLS/C1150481 denotes esul
T17642 27395-27399 UMLS/C1150481 denotes down
T17641 26962-26966 UMLS/C1150481 denotes ind
T17640 26753-26757 UMLS/C1150481 denotes to
T17639 26586-26590 UMLS/C1150481 denotes atio
T17638 25888-25892 UMLS/C1150481 denotes inh
T17637 24146-24167 UP/P59684 denotes mor necrosis factor-s
T17636 27374-27377 UMLS/C1518422 denotes lth
T17635 27335-27338 UMLS/C1518422 denotes in
T17634 26435-26438 UMLS/C1518422 denotes ted
T17633 23570-23573 UMLS/C1518422 denotes t t
T17632 23361-23364 UMLS/C1518422 denotes t s
T17631 23157-23160 UMLS/C0031858 denotes A a
T17630 25617-25624 UMLS/C1704787 denotes ain sig
T17629 22635-22644 UMLS/C1552738 denotes scribed a
T17628 22020-22029 UMLS/C1552738 denotes described
T17627 26938-26946 UMLS/C1705910 denotes volvemen
T17626 28078-28086 UMLS/C0599894 denotes es in RA
T17625 24899-24909 UMLS/C1705912 denotes perties an
T17624 22695-22705 UMLS/C1705912 denotes operties.
T17623 22071-22081 UMLS/C1705912 denotes properties
T17622 27913-27922 UMLS/C0205263 denotes i-IL-17 f
T17621 27549-27557 UMLS/C0205263 denotes are lac
T17620 27187-27196 UMLS/C0205263 denotes IL-17 in
T17619 26974-26983 UMLS/C0205263 denotes f IL-17 i
T17618 26032-26039 UMLS/C0205263 denotes ed IL-1
T17617 25818-25825 UMLS/C0205263 denotes ced IL-
T17616 25759-25768 UMLS/C0205263 denotes ction of
T17615 25403-25412 UMLS/C0205263 denotes ction in
T17614 25158-25165 UMLS/C0205263 denotes ces T c
T17613 24991-25006 UMLS/C0332290 denotes sistent with a
T17612 24146-24167 UP/P79374 denotes mor necrosis factor-s
T17611 25545-25552 UMLS/C1546437 denotes ata hav
T17610 25130-25137 UMLS/C1546437 denotes ata tha
T17609 23024-23031 UMLS/C0205250 denotes ghest l
T17608 22860-22866 UMLS/C0205250 denotes gher i
T17607 24146-24167 UP/P79337 denotes mor necrosis factor-s
T17606 26389-26396 UMLS/C1274040 denotes evealed
T17605 26389-26396 UMLS/C0332294 denotes evealed
T17604 24146-24167 UP/P59693 denotes mor necrosis factor-s
T17603 27542-27548 UMLS/C1710082 denotes g IL-1
T17602 27498-27505 UMLS/C1710082 denotes y cell
T17601 23208-23217 UMLS/C1710082 denotes gnaling t
T17600 26571-26582 UMLS/C0332291 denotes t of PI3K a
T17599 26635-26638 UMLS/C1150588 denotes -κB
T17598 26285-26288 UMLS/C1150588 denotes sti
T17597 26257-26260 UMLS/C1150588 denotes , a
T17596 26208-26211 UMLS/C1150588 denotes n m
T17595 26526-26551 UMLS/C1698593 denotes he evidence for a p38 MAP
T17594 22396-22402 UMLS/C0442726 denotes tect i
T17593 24146-24167 UP/Q8HZD9 denotes mor necrosis factor-s
T17592 25312-25318 UMLS/C2347086 denotes al ind
T17591 28052-28059 UMLS/C0021223 denotes oping n
T17590 27913-27922 UMLS/C1621983 denotes i-IL-17 f
T17589 27187-27196 UMLS/C1621983 denotes IL-17 in
T17588 26974-26983 UMLS/C1621983 denotes f IL-17 i
T17587 25759-25768 UMLS/C1621983 denotes ction of
T17586 25403-25412 UMLS/C1621983 denotes ction in
T17585 27693-27705 UMLS/C0041904 denotes IL-17 in RA
T17584 23383-23395 UMLS/C0041904 denotes regulation o
T17583 24137-24141 UMLS/C1527432 denotes -8 a
T17582 22657-22664 UMLS/C2348040 denotes rived c
T17581 22533-22540 UMLS/C2348040 denotes rived c
T17580 22311-22318 UMLS/C2348040 denotes erived
T17305 26635-26638 UP/Q9NV58 denotes -κB
T17304 26285-26288 UP/Q9NV58 denotes sti
T17303 26257-26260 UP/Q9NV58 denotes , a
T17302 26208-26211 UP/Q9NV58 denotes n m
T17301 23854-23859 UMLS/C0335295 denotes del [
T17300 27775-27783 UMLS/C1533157 denotes κB bindi
T17299 24899-24909 UMLS/C2347695 denotes perties an
T17298 22695-22705 UMLS/C2347695 denotes operties.
T17297 22071-22081 UMLS/C2347695 denotes properties
T17296 26554-26562 UP/Q16539 denotes athway i
T17295 26411-26419 UP/Q16539 denotes activati
T17294 26106-26114 UP/Q16539 denotes APK inhi
T17293 24749-24755 UMLS/C1720086 denotes ding I
T17292 24778-24786 UMLS/C0023690 denotes gation a
T17291 24680-24688 UMLS/C0023690 denotes gation s
T17290 27476-27478 UMLS/C0319022 denotes iv
T17289 26765-26767 UMLS/C0319022 denotes ax
T17288 26677-26679 UMLS/C0319022 denotes ed
T17287 25942-25944 UMLS/C0319022 denotes mp
T17286 24914-24916 UMLS/C0319022 denotes be
T17285 24875-24877 UMLS/C0319022 denotes ha
T17284 24771-24773 UMLS/C0319022 denotes T
T17283 24382-24384 UMLS/C0319022 denotes r
T17282 24094-24096 UMLS/C0319022 denotes s
T17281 24584-24592 UMLS/C0023690 denotes gation u
T17280 26683-26690 UMLS/C1880229 denotes future
T17279 24623-24630 UMLS/C1880229 denotes udies d
T17278 22714-22721 UMLS/C1880229 denotes udies,
T17277 24506-24513 UMLS/C1883525 denotes riety o
T17276 23940-23947 UMLS/C1883525 denotes riety o
T17275 23461-23463 UMLS/C0319022 denotes c
T17274 26554-26562 UMLS/C1120843 denotes athway i
T17273 26411-26419 UMLS/C1120843 denotes activati
T17272 26106-26114 UMLS/C1120843 denotes APK inhi
T17271 22376-22382 UMLS/C0700164 denotes oved d
T17270 24146-24167 UMLS/C1522668 denotes mor necrosis factor-s
T17269 27612-27616 UMLS/C0285761 denotes esul
T17268 27395-27399 UMLS/C0285761 denotes down
T17267 26962-26966 UMLS/C0285761 denotes ind
T17266 26753-26757 UMLS/C0285761 denotes to
T17265 26586-26590 UMLS/C0285761 denotes atio
T17264 25888-25892 UMLS/C0285761 denotes inh
T17263 25079-25082 UMLS/C0005341 denotes TN
T17262 23418-23420 UMLS/C0319022 denotes i
T17261 22854-22856 UMLS/C0319022 denotes b
T17260 22732-22734 UMLS/C0319022 denotes e
T17259 22393-22395 UMLS/C0319022 denotes d
T17258 22259-22267 UMLS/C2346714 denotes bundant
T17257 27775-27783 UMLS/C0028778 denotes κB bindi
T17256 23854-23859 UMLS/C0302143 denotes del [
T17255 27775-27783 UMLS/C0233660 denotes κB bindi
T17254 22376-22382 UMLS/C0456369 denotes oved d
T17253 26683-26690 UMLS/C0947630 denotes future
T17252 24623-24630 UMLS/C0947630 denotes udies d
T17251 22714-22721 UMLS/C0947630 denotes udies,
T17250 22042-22049 UMLS/C1514468 denotes product
T17249 26571-26582 UMLS/C0085862 denotes t of PI3K a
T17248 26554-26562 UP/P41279 denotes athway i
T17247 26411-26419 UP/P41279 denotes activati
T17246 26106-26114 UP/P41279 denotes APK inhi
T17245 27794-27801 UMLS/C1145667 denotes in the
T17244 26476-26483 UMLS/C1145667 denotes tivity
T17243 22165-22177 UMLS/C1523986 denotes infiltration
T17242 27794-27801 UMLS/C2349209 denotes in the
T17241 26476-26483 UMLS/C2349209 denotes tivity
T17240 22555-22562 UMLS/C2349209 denotes mited i
T17239 26110-26124 UMLS/C1513344 denotes inhibitor. It
T17238 27309-27318 UMLS/C0079189 denotes mokines,
T17237 24517-24526 UMLS/C0079189 denotes tokines/c
T17236 24338-24347 UMLS/C0079189 denotes tokines (
T17235 24113-24122 UMLS/C0079189 denotes tokines s
T17234 23967-23976 UMLS/C0079189 denotes tokines a
T17233 22665-22673 UMLS/C0079189 denotes tokine w
T17232 22541-22550 UMLS/C0079189 denotes tokines h
T17231 22319-22328 UMLS/C0079189 denotes ytokines,
T17230 22221-22230 UMLS/C0079189 denotes cytokines
T17229 27235-27239 UMLS/C0085828 denotes rans
T17228 26635-26638 UMLS/C1366876 denotes -κB
T17227 26285-26288 UMLS/C1366876 denotes sti
T17226 26257-26260 UMLS/C1366876 denotes , a
T17225 26208-26211 UMLS/C1366876 denotes n m
T17224 26170-26178 UMLS/C1521721 denotes rts cros
T17363 28012-28017 UMLS/C1522571 denotes pathw
T17362 27818-27823 UMLS/C1522571 denotes y PDT
T17361 27709-27714 UMLS/C1522571 denotes the
T17360 27558-27563 UMLS/C1522571 denotes ing.
T17359 27200-27205 UMLS/C1522571 denotes BMC.
T17358 26987-26992 UMLS/C1522571 denotes . In
T17357 25772-25777 UMLS/C1522571 denotes 7 in
T17356 25501-25506 UMLS/C1522571 denotes 7 has
T17355 25397-25402 UMLS/C1522571 denotes 7 ind
T15816 21615-21620 UMLS/C1825592 denotes romot
T15815 21084-21089 UMLS/C1825592 denotes 17 pr
T15814 20933-20938 UMLS/C1825592 denotes -17.
T15813 20807-20812 UMLS/C1825592 denotes L-17
T15812 20628-20633 UMLS/C1825592 denotes L-17
T15811 21906-21910 UMLS/C0024497 denotes llul
T15788 20961-20977 UMLS/C1518434 denotes clear extracts f
T15787 21127-21135 UMLS/C0332298 denotes trols (l
T15786 21419-21423 UMLS/C1517892 denotes bet
T15785 20798-20806 UMLS/C0205263 denotes nducing
T15784 21840-21844 UMLS/C0332287 denotes D28
T15783 21340-21344 UMLS/C0332287 denotes ant
T15782 21016-21020 UMLS/C0332287 denotes us a
T15781 20731-20735 UMLS/C0332287 denotes lus
T15780 21691-21702 UMLS/C0243125 denotes on of IκB-α
T15779 21195-21198 UMLS/C1335610 denotes an
T15778 21500-21507 UMLS/C0243122 denotes g activ
T15777 21063-21070 UMLS/C0243122 denotes nding o
T15776 21249-21255 UMLS/C2347086 denotes mal PB
T15775 21567-21573 UMLS/C1521826 denotes block
T15774 21906-21910 UMLS/C0205225 denotes llul
T15773 21677-21687 UMLS/C1628982 denotes n of degra
T15772 21053-21062 UMLS/C0205217 denotes creased b
T15771 21742-21746 UMLS/C1692345 denotes Fig.
T15770 21265-21269 UMLS/C1692345 denotes e pa
T15769 21159-21164 UMLS/C0005507 denotes ay de
T15768 20872-20877 UMLS/C0005507 denotes ssay
T15767 21747-21751 UMLS/C1704250 denotes 7c).
T15766 21249-21255 UMLS/C0439166 denotes mal PB
T15765 21976-21980 UMLS/C1321301 denotes tien
T15764 21388-21392 UMLS/C1321301 denotes (Fi
T15763 21256-21260 UMLS/C1321301 denotes C th
T15762 20986-20990 UMLS/C1321301 denotes MC s
T15761 21599-21607 UMLS/C0439167 denotes y in the
T15760 21508-21516 UMLS/C0439167 denotes ty after
T15759 21437-21445 UMLS/C0439167 denotes vity and
T15758 21195-21198 UP/P48018 denotes an
T15757 21785-21792 UMLS/C1704259 denotes not ac
T15756 20613-20620 UMLS/C1704259 denotes athway
T15755 21127-21135 UMLS/C0243148 denotes trols (l
T15754 21856-21860 UMLS/C1511726 denotes own)
T15753 21471-21475 UMLS/C0596608 denotes to d
T15752 20879-20883 UMLS/C0596608 denotes MSA)
T15751 21203-21206 UMLS/C1539081 denotes (l
T15750 21186-21191 UMLS/C0439645 denotes ds in
T15749 21906-21910 UMLS/C1542147 denotes llul
T15748 21195-21198 UMLS/C1420556 denotes an
T15747 21925-21942 UMLS/C0037080 denotes thway in IL-17 pr
T15746 20691-20708 UMLS/C0037080 denotes ignaling pathway
T15745 21230-21235 UMLS/C0035018 denotes el (l
T15744 20895-20906 UMLS/C0524637 denotes cognition s
T15743 21780-21784 UP/P21525 denotes y wa
T15742 20607-20611 UP/P21525 denotes P-1)
T15741 21195-21198 UMLS/C0599933 denotes an
T15740 21432-21436 UMLS/C1705325 denotes act
T15739 21282-21290 UMLS/C1441672 denotes erved, b
T15738 21127-21135 UMLS/C1547100 denotes trols (l
T15737 21419-21423 UMLS/C0208973 denotes bet
T15736 21500-21507 UMLS/C1689898 denotes g activ
T15735 21063-21070 UMLS/C1689898 denotes nding o
T15734 21300-21306 UMLS/C0449286 denotes ree of
T15733 21249-21255 UMLS/C1873497 denotes mal PB
T15732 21195-21198 UP/P21521 denotes an
T15731 21599-21607 UMLS/C0441655 denotes y in the
T15730 21508-21516 UMLS/C0441655 denotes ty after
T15729 21437-21445 UMLS/C0441655 denotes vity and
T15728 21677-21687 UMLS/C0021467 denotes n of degra
T15727 21677-21687 UMLS/C0021469 denotes n of degra
T15726 21911-21924 UMLS/C0178719 denotes r signaling p
T15725 20677-20690 UMLS/C0178719 denotes ntracellular
T15724 21753-21756 UMLS/C0349966 denotes n c
T15723 21631-21634 UMLS/C0349966 denotes ).
T15722 21394-21397 UMLS/C0349966 denotes 7b
T15721 20952-20955 UMLS/C0349966 denotes g.
T15720 21780-21784 UP/A8MPH9 denotes y wa
T15719 20607-20611 UP/A8MPH9 denotes P-1)
T15718 21053-21062 UMLS/C0442805 denotes creased b
T15717 21053-21062 UMLS/C0442808 denotes creased b
T15716 21747-21751 UMLS/C0449243 denotes 7c).
T15715 21471-21475 UMLS/C0949632 denotes to d
T15714 20879-20883 UMLS/C0949632 denotes MSA)
T15713 21103-21113 UMLS/C1707455 denotes parison wi
T15712 21747-21751 UMLS/C0040223 denotes 7c).
T15711 21127-21135 UMLS/C1550141 denotes trols (l
T15710 21186-21191 UMLS/C0185014 denotes ds in
T15709 21178-21185 UMLS/C0333051 denotes fted ba
T15708 21567-21573 UMLS/C1254351 denotes block
T15707 21780-21784 UMLS/C0087140 denotes y wa
T15706 20607-20611 UMLS/C0087140 denotes P-1)
T15705 21300-21306 UMLS/C0542560 denotes ree of
T15704 20907-20912 UMLS/C1546778 denotes tes i
T15703 20771-20776 UMLS/C1149222 denotes L-15,
T15702 20634-20649 UMLS/C0033413 denotes romoter region
T15701 20763-20766 UMLS/C0030779 denotes HA
T15700 21407-21414 UMLS/C1446409 denotes irm the
T15699 21300-21306 UMLS/C0441889 denotes ree of
T15698 21195-21198 UP/P47191 denotes an
T15697 20653-20664 UMLS/C1292732 denotes nvestigate
T15696 20771-20776 UMLS/C0254610 denotes L-15,
T15695 20813-20823 UMLS/C0185117 denotes xpression,
T15694 21159-21164 UMLS/C1510438 denotes ay de
T15693 20872-20877 UMLS/C1510438 denotes ssay
T15692 21270-21277 UMLS/C0449774 denotes tern wa
T15691 21203-21206 UP/P83939 denotes (l
T15690 21966-21975 UMLS/C1879547 denotes MC from p
T15689 21801-21810 UMLS/C1879547 denotes y stimula
T15688 21317-21327 UMLS/C1879547 denotes vation by
T15687 20709-20718 UMLS/C1879547 denotes ctivated
T15686 20557-20567 UMLS/C1879547 denotes Activation
T15685 20771-20776 UMLS/C1334105 denotes L-15,
T15684 20907-20912 UMLS/C2347790 denotes tes i
T15683 21780-21784 UMLS/C0162508 denotes y wa
T15682 20607-20611 UMLS/C0162508 denotes P-1)
T15681 21203-21206 UMLS/C1417708 denotes (l
T15680 21517-21532 UMLS/C0001758 denotes treatment with
T15679 20782-20793 UMLS/C1273518 denotes esponsible
T15678 21780-21784 UMLS/C1333571 denotes y wa
T15677 20607-20611 UMLS/C1333571 denotes P-1)
T15676 21814-21825 UMLS/C1948023 denotes with anti-
T15675 20991-21001 UMLS/C1948023 denotes imulated w
T15674 21641-21657 UMLS/C0005863 denotes blotting for Iκ
T15673 21127-21135 UMLS/C0009932 denotes trols (l
T15672 21432-21436 UP/P42336 denotes act
T15671 21461-21470 UMLS/C0884358 denotes rmed EMSA
T15670 20828-20837 UMLS/C0884358 denotes erformed
T15669 21641-21657 UMLS/C0949466 denotes blotting for Iκ
T15668 21691-21702 UMLS/C0699900 denotes on of IκB-α
T15667 21717-21725 UMLS/C0251991 denotes d PDTC a
T15666 21543-21551 UMLS/C0251991 denotes 02 and P
T15665 21615-21620 UMLS/C1522571 denotes romot
T15664 21084-21089 UMLS/C1522571 denotes 17 pr
T15663 20933-20938 UMLS/C1522571 denotes -17.
T15662 20807-20812 UMLS/C1522571 denotes L-17
T15661 20628-20633 UMLS/C1522571 denotes L-17
T15660 21814-21825 UMLS/C1292856 denotes with anti-
T15659 21730-21734 UMLS/C0084183 denotes sam
T15658 21556-21560 UMLS/C0084183 denotes Both
T15657 21911-21924 UMLS/C0175996 denotes r signaling p
T15656 20677-20690 UMLS/C0175996 denotes ntracellular
T15655 21567-21573 UMLS/C0450442 denotes block
T15654 21615-21620 UMLS/C0384648 denotes romot
T15653 21084-21089 UMLS/C0384648 denotes 17 pr
T15652 20933-20938 UMLS/C0384648 denotes -17.
T15651 20807-20812 UMLS/C0384648 denotes L-17
T15650 20628-20633 UMLS/C0384648 denotes L-17
T15649 21599-21607 UMLS/C1561536 denotes y in the
T15648 21508-21516 UMLS/C1561536 denotes ty after
T15647 21437-21445 UMLS/C1561536 denotes vity and
T15646 20813-20823 UMLS/C0017262 denotes xpression,
T15645 21432-21436 UMLS/C1368105 denotes act
T15644 21461-21470 UMLS/C1550369 denotes rmed EMSA
T15643 20828-20837 UMLS/C1550369 denotes erformed
T15642 21479-21488 UMLS/C0521095 denotes mine the
T15641 21574-21579 UMLS/C0332206 denotes NF-κB
T15640 21407-21414 UMLS/C0521093 denotes irm the
T15639 21574-21579 UMLS/C1706084 denotes NF-κB
T15638 21747-21751 UMLS/C1548318 denotes 7c).
T15637 20907-20912 UMLS/C0205145 denotes tes i
T15636 21159-21164 UMLS/C0243073 denotes ay de
T15635 20872-20877 UMLS/C0243073 denotes ssay
T15634 21407-21414 UMLS/C1456348 denotes irm the
T15633 21925-21942 UMLS/C0086982 denotes thway in IL-17 pr
T15632 20691-20708 UMLS/C0086982 denotes ignaling pathway
T15631 21500-21507 UMLS/C1167622 denotes g activ
T15630 21063-21070 UMLS/C1167622 denotes nding o
T15629 21574-21579 UMLS/C1533157 denotes NF-κB
T15628 21615-21620 UMLS/C1623218 denotes romot
T15627 21084-21089 UMLS/C1623218 denotes 17 pr
T15626 20933-20938 UMLS/C1623218 denotes -17.
T15625 20807-20812 UMLS/C1623218 denotes L-17
T15624 20628-20633 UMLS/C1623218 denotes L-17
T15623 21203-21206 UP/Q05894 denotes (l
T15622 21300-21306 UMLS/C1561545 denotes ree of
T15621 21203-21206 UP/P23061 denotes (l
T15620 20957-20959 UMLS/C1553639 denotes ,
T15619 21747-21751 UMLS/C1547403 denotes 7c).
T15618 21747-21751 UMLS/C1632851 denotes 7c).
T15617 21249-21255 UMLS/C1704701 denotes mal PB
T15616 20747-20761 UMLS/C0009630 denotes oncanavalin A,
T15615 21292-21295 UMLS/C0005341 denotes th
T15614 21432-21436 UMLS/C0285761 denotes act
T15613 21195-21198 UP/P41823 denotes an
T15612 21476-21478 UMLS/C0319022 denotes te
T15611 21404-21406 UMLS/C0319022 denotes on
T15610 21081-21083 UMLS/C0319022 denotes IL
T15609 20650-20652 UMLS/C0319022 denotes o
T15608 21747-21751 UMLS/C0392761 denotes 7c).
T15607 21574-21579 UMLS/C0028778 denotes NF-κB
T15606 21249-21255 UMLS/C1550457 denotes mal PB
T15605 21574-21579 UMLS/C0233660 denotes NF-κB
T15604 21621-21629 UMLS/C0086860 denotes r (Fig.
T15603 21090-21099 UMLS/C0086860 denotes moters in
T15602 20920-20929 UMLS/C0086860 denotes omoters o
T15601 21780-21784 UMLS/C0812312 denotes y wa
T15600 20607-20611 UMLS/C0812312 denotes P-1)
T15599 21407-21414 UMLS/C0750484 denotes irm the
T15598 20907-20912 UMLS/C1515974 denotes tes i
T15597 21500-21507 UMLS/C1145667 denotes g activ
T15596 21063-21070 UMLS/C1145667 denotes nding o
T15595 21742-21746 UMLS/C0445247 denotes Fig.
T15594 21265-21269 UMLS/C0445247 denotes e pa
T15593 21249-21255 UMLS/C1551394 denotes mal PB
T15592 21500-21507 UMLS/C2349209 denotes g activ
T15591 21063-21070 UMLS/C2349209 denotes nding o
T15590 21364-21371 UMLS/C0522510 denotes nse tha
T15589 21780-21784 UMLS/C0085828 denotes y wa
T15588 20607-20611 UMLS/C0085828 denotes P-1)
T15587 20586-20605 UMLS/C0085828 denotes ctivator protein-1
T15586 21203-21206 UMLS/C1705525 denotes (l
T15585 21766-21774 UMLS/C1979874 denotes he AP-1
T15584 21127-21135 UMLS/C1882979 denotes trols (l
T15583 21587-21598 UMLS/C1148673 denotes ding activi
T15582 21419-21423 UMLS/C1704666 denotes bet
T15810 21946-21962 UMLS/C1819444 denotes tion by activate
T15809 21203-21206 UP/Q28618 denotes (l
T15808 21127-21135 UMLS/C2587213 denotes trols (l
T15807 21567-21573 UMLS/C1551364 denotes block
T15806 21178-21185 UMLS/C2347509 denotes fted ba
T15805 21195-21198 UP/P21707 denotes an
T15804 21186-21191 UMLS/C0175723 denotes ds in
T15803 21249-21255 UMLS/C0205307 denotes mal PB
T15802 21195-21198 UP/P46096 denotes an
T15801 21195-21198 UP/P21579 denotes an
T15800 21300-21306 UMLS/C2348088 denotes ree of
T15799 21785-21792 UMLS/C1705987 denotes not ac
T15798 20613-20620 UMLS/C1705987 denotes athway
T15797 21432-21436 UMLS/C1150481 denotes act
T15796 21861-21864 UMLS/C1518422 denotes de
T15795 21797-21800 UMLS/C1518422 denotes ed
T15794 21223-21226 UMLS/C1518422 denotes in
T15793 21237-21241 UMLS/C1708639 denotes e 5)
T15792 21208-21213 UMLS/C1708639 denotes es 3
T15791 21137-21141 UMLS/C1708639 denotes e 1)
T15790 21032-21036 UMLS/C1708639 denotes ne 2
T15789 20763-20766 UMLS/C0031858 denotes HA
T14927 20306-20312 UP/P26183 denotes n rema
T14926 20306-20312 UP/P50138 denotes n rema
T14925 19780-19796 UMLS/C1819444 denotes IL-17 production
T14924 20387-20392 UMLS/C1149222 denotes also
T14923 20222-20226 UMLS/C0444505 denotes ak a
T14922 20101-20107 UMLS/C1442458 denotes min o
T14921 20363-20366 UMLS/C0030779 denotes con
T14920 20306-20312 UP/P24902 denotes n rema
T14919 20306-20312 UP/P30161 denotes n rema
T14918 20259-20262 UMLS/C1552937 denotes In
T14917 20233-20236 UMLS/C1552937 denotes n,
T14916 20306-20312 UP/P11426 denotes n rema
T14915 20306-20312 UP/Q2U7A3 denotes n rema
T14914 20306-20312 UP/Q11212 denotes n rema
T14913 19876-19885 UMLS/C0220825 denotes evaluated
T14912 20387-20392 UMLS/C0254610 denotes also
T14911 20042-20049 UMLS/C1265611 denotes ounts o
T14910 20306-20312 UP/Q92192 denotes n rema
T14909 20306-20312 UP/P91754 denotes n rema
T14908 20095-20100 UMLS/C0231290 denotes ter 3
T14907 20420-20426 UMLS/C2348382 denotes t on p
T14906 20170-20176 UMLS/C2348382 denotes fect o
T14905 20306-20312 UP/P10989 denotes n rema
T14904 20306-20312 UP/Q8SWN8 denotes n rema
T14903 20306-20312 UP/P51775 denotes n rema
T14902 20306-20312 UP/P68555 denotes n rema
T14901 20306-20312 UP/P20904 denotes n rema
T14900 19864-19871 UMLS/C1705987 denotes pathway
T14899 20306-20312 UP/P13363 denotes n rema
T14898 20306-20312 UP/P53500 denotes n rema
T14897 19890-19900 UMLS/C1879547 denotes activation
T14896 19726-19736 UMLS/C1879547 denotes Activation
T14895 19859-19863 UMLS/C1150481 denotes PI3K
T14894 19740-19744 UMLS/C1150481 denotes PI3K
T14893 20306-20312 UP/P53498 denotes n rema
T14892 20306-20312 UP/P60011 denotes n rema
T14891 20306-20312 UP/P26182 denotes n rema
T14890 20549-20552 UMLS/C1518422 denotes how
T14889 20204-20208 UMLS/C1708639 denotes ne 3
T14888 20153-20157 UMLS/C1708639 denotes ne 2
T14887 20363-20366 UMLS/C0031858 denotes con
T14886 20259-20262 UMLS/C0439232 denotes In
T14885 20233-20236 UMLS/C0439232 denotes n,
T14884 20387-20392 UMLS/C1334105 denotes also
T14883 20420-20426 UMLS/C1280500 denotes t on p
T14882 20170-20176 UMLS/C1280500 denotes fect o
T14881 20259-20262 UMLS/C0702093 denotes In
T14880 20233-20236 UMLS/C0702093 denotes n,
T14879 20306-20312 UP/P14235 denotes n rema
T14878 20306-20312 UP/P53476 denotes n rema
T14877 20306-20312 UP/P60010 denotes n rema
T14876 20306-20312 UMLS/C0001271 denotes n rema
T14875 20306-20312 UP/P53502 denotes n rema
T14874 20095-20100 UMLS/C0687676 denotes ter 3
T14873 19911-19927 UMLS/C0005863 denotes western blotting
T14872 20313-20321 UMLS/C1527428 denotes ned unch
T14871 20306-20312 UP/Q8X119 denotes n rema
T14870 20306-20312 UP/P10365 denotes n rema
T14869 19859-19863 UP/P42336 denotes PI3K
T14868 19740-19744 UP/P42336 denotes PI3K
T14867 20306-20312 UP/P53455 denotes n rema
T14866 20306-20312 UP/O81221 denotes n rema
T14865 20486-20496 UMLS/C1628982 denotes ition by w
T14864 20180-20190 UMLS/C1628982 denotes hibition b
T14863 20306-20312 UP/Q9UVF3 denotes n rema
T14862 19911-19927 UMLS/C0949466 denotes western blotting
T14861 20534-20542 UMLS/C0251991 denotes 002 (dat
T14860 20194-20202 UMLS/C0251991 denotes 294002 (
T14859 20002-20010 UMLS/C0251991 denotes Y294002
T14858 20142-20151 UMLS/C0205217 denotes creased (
T14857 20415-20419 UMLS/C1692345 denotes effe
T14856 20357-20361 UMLS/C1704250 denotes PHA
T14855 20306-20312 UP/Q39758 denotes n rema
T14854 20515-20519 UMLS/C0084183 denotes as w
T14484 19579-19584 UMLS/C1825592 denotes -17 m
T14483 19334-19339 UMLS/C1825592 denotes IL-17
T14482 19391-19407 UMLS/C1819444 denotes IL-17 production
T14481 19408-19413 UMLS/C0344312 denotes could
T14480 19527-19536 UMLS/C1550369 denotes rformed.
T14479 19448-19453 UMLS/C0441889 denotes level
T14478 19497-19522 UMLS/C0032520 denotes lymerase chain reaction w
T14477 19432-19447 UMLS/C0040649 denotes transcriptional
T14476 19417-19426 UMLS/C0851285 denotes regulated
T14475 19703-19712 UMLS/C0243077 denotes ibitor PD
T14474 19666-19675 UMLS/C0243077 denotes hibitor L
T14473 19408-19413 UMLS/C0006823 denotes could
T14472 19602-19607 UMLS/C0231290 denotes ter s
T14471 19590-19601 UMLS/C1519595 denotes anscripts a
T14470 19370-19373 UMLS/C0042789 denotes see
T14469 19473-19480 UMLS/C1555029 denotes reverse
T14468 19661-19665 UMLS/C1705325 denotes 3K i
T14467 19579-19584 UMLS/C1623218 denotes -17 m
T14466 19334-19339 UMLS/C1623218 denotes IL-17
T14465 19552-19566 UMLS/C1512045 denotes se-dependent i
T14464 19703-19712 UMLS/C1999216 denotes ibitor PD
T14463 19666-19675 UMLS/C1999216 denotes hibitor L
T14462 19661-19665 UMLS/C1150481 denotes 3K i
T14461 19541-19549 UMLS/C1441672 denotes served a
T14460 19382-19390 UMLS/C1999177 denotes enhanced
T14459 19644-19653 UMLS/C0021469 denotes hibited b
T14458 19661-19665 UMLS/C0285761 denotes 3K i
T14457 19367-19369 UMLS/C0319022 denotes To
T14456 19608-19619 UMLS/C1948023 denotes imulation w
T14455 19602-19607 UMLS/C0687676 denotes ter s
T14454 19585-19589 UMLS/C0035696 denotes NA t
T14453 19719-19722 UMLS/C0349966 denotes . 5
T14452 19382-19390 UMLS/C2349975 denotes enhanced
T14451 19661-19665 UP/P42336 denotes 3K i
T14450 19567-19575 UMLS/C0442805 denotes crease i
T14449 19340-19355 UMLS/C1515670 denotes mRNA expression
T14448 19567-19575 UMLS/C0442808 denotes crease i
T14447 19527-19536 UMLS/C0884358 denotes rformed.
T14446 19676-19684 UMLS/C0251991 denotes 294002 a
T14445 19579-19584 UMLS/C1522571 denotes -17 m
T14444 19334-19339 UMLS/C1522571 denotes IL-17
T14443 19567-19575 UMLS/C0205217 denotes crease i
T14442 19608-19619 UMLS/C1292856 denotes imulation w
T14441 19448-19453 UMLS/C0456079 denotes level
T14440 19713-19717 UMLS/C0084183 denotes C (F
T14439 19362-19366 UMLS/C1321301 denotes PBMC
T14438 19579-19584 UMLS/C0384648 denotes -17 m
T14437 19334-19339 UMLS/C0384648 denotes IL-17
T14853 20306-20312 UP/Q05214 denotes n rema
T14852 20306-20312 UP/Q99023 denotes n rema
T14851 20306-20312 UP/O00937 denotes n rema
T14850 20306-20312 UP/P80709 denotes n rema
T14849 19864-19871 UMLS/C1704259 denotes pathway
T14848 20306-20312 UP/P78711 denotes n rema
T14847 20306-20312 UP/Q75D00 denotes n rema
T14846 19859-19863 UMLS/C1368105 denotes PI3K
T14845 19740-19744 UMLS/C1368105 denotes PI3K
T14844 20544-20548 UMLS/C1511726 denotes not
T14843 19812-19821 UMLS/C0521095 denotes determine
T14842 20306-20312 UP/P53477 denotes n rema
T14841 20306-20312 UP/Q6TCF2 denotes n rema
T14840 20306-20312 UP/Q92193 denotes n rema
T14839 20346-20356 UMLS/C1980044 denotes ation time
T14838 20111-20121 UMLS/C1980044 denotes cubation,
T14837 19962-19972 UMLS/C1980044 denotes incubation
T14836 20357-20361 UMLS/C1548318 denotes PHA
T14835 20306-20312 UP/P53491 denotes n rema
T14834 20322-20331 UMLS/C0442739 denotes nged rega
T14833 19749-19776 UMLS/C0086982 denotes signal transduction pathway
T14832 20306-20312 UP/O65314 denotes n rema
T14831 20042-20049 UMLS/C1561574 denotes ounts o
T14830 20306-20312 UP/Q24733 denotes n rema
T14829 20500-20510 UMLS/C0078517 denotes annin and
T14828 20076-20084 UMLS/C1441672 denotes served.
T14827 20306-20312 UP/Q39596 denotes n rema
T14826 20306-20312 UP/P53689 denotes n rema
T14825 20306-20312 UP/A5DQP9 denotes n rema
T14824 20357-20361 UMLS/C1547403 denotes PHA
T14823 20306-20312 UP/O17320 denotes n rema
T14822 20322-20331 UMLS/C2346711 denotes nged rega
T14821 20306-20312 UP/P81085 denotes n rema
T14820 20306-20312 UP/O65315 denotes n rema
T14819 20486-20496 UMLS/C0021467 denotes ition by w
T14818 20180-20190 UMLS/C0021467 denotes hibition b
T14817 20486-20496 UMLS/C0021469 denotes ition by w
T14816 20180-20190 UMLS/C0021469 denotes hibition b
T14815 20306-20312 UP/O16808 denotes n rema
T14814 20357-20361 UMLS/C1632851 denotes PHA
T14813 20306-20312 UP/Q9UVZ8 denotes n rema
T14812 20306-20312 UP/P45520 denotes n rema
T14811 20368-20382 UMLS/C0009630 denotes navalin A and
T14810 19859-19863 UMLS/C0285761 denotes PI3K
T14809 19740-19744 UMLS/C0285761 denotes PI3K
T14808 20246-20248 UMLS/C0319022 denotes 1
T14807 19809-19811 UMLS/C0319022 denotes To
T14806 20101-20107 UMLS/C0456693 denotes min o
T14805 20357-20361 UMLS/C0392761 denotes PHA
T14804 20306-20312 UP/O65316 denotes n rema
T14803 20306-20312 UP/P60009 denotes n rema
T14802 20445-20448 UP/Q8INB9 denotes s s
T14801 20296-20299 UP/Q8INB9 denotes and
T14800 20357-20361 UMLS/C0040223 denotes PHA
T14799 20267-20275 UMLS/C1979874 denotes rast, no
T14798 20024-20034 UMLS/C1705242 denotes fference i
T14797 19842-19851 UMLS/C0567416 denotes molecules
T14796 20024-20034 UMLS/C1705241 denotes fference i
T14795 20306-20312 UP/P45521 denotes n rema
T14794 20306-20312 UP/P48465 denotes n rema
T14793 20306-20312 UP/O13419 denotes n rema
T14792 20212-20219 UMLS/C0596012 denotes ached a
T14791 20238-20245 UMLS/C1517741 denotes sting t
T14790 20306-20312 UP/P17128 denotes n rema
T14789 19859-19863 UMLS/C1705325 denotes PI3K
T14788 19740-19744 UMLS/C1705325 denotes PI3K
T14787 20523-20527 UMLS/C0205170 denotes as b
T14786 20306-20312 UMLS/C0439681 denotes n rema
T14785 20138-20141 UP/Q8INB9 denotes t i
T14784 20068-20071 UP/Q8INB9 denotes t w
T14783 19904-19907 UP/Q8INB9 denotes Akt
T14782 19745-19748 UP/Q8INB9 denotes Akt
T14781 20346-20356 UMLS/C1979572 denotes ation time
T14780 20111-20121 UMLS/C1979572 denotes cubation,
T14779 19962-19972 UMLS/C1979572 denotes incubation
T14778 19941-19944 UMLS/C0349966 denotes Fig
T14777 20306-20312 UP/P90689 denotes n rema
T14776 20306-20312 UP/Q9UVX4 denotes n rema
T14775 20306-20312 UP/P53499 denotes n rema
T14774 20306-20312 UP/Q9P4D1 denotes n rema
T14773 20306-20312 UP/O74258 denotes n rema
T14772 20142-20151 UMLS/C0442805 denotes creased (
T14771 20142-20151 UMLS/C0442808 denotes creased (
T14770 19952-19958 UMLS/C0456692 denotes 10 min
T14769 20357-20361 UMLS/C0449243 denotes PHA
T14768 19822-19832 UMLS/C0522506 denotes downstream
T14767 20415-20419 UMLS/C0445247 denotes effe
T14486 19661-19665 UMLS/C1368105 denotes 3K i
T14485 19635-19639 UMLS/C0323983 denotes is w
T13527 17972-17992 UMLS/C0003191 denotes anti-rheumatic drugs
T13526 18752-18755 UP/Q01552 denotes ibi
T13525 18827-18832 UMLS/C1825592 denotes evels
T13524 18681-18686 UMLS/C1825592 denotes ecret
T13523 18752-18755 UP/O95433 denotes ibi
T13522 19081-19097 UMLS/C1819444 denotes roduction with c
T13521 19014-19030 UMLS/C1819444 denotes roduction in PBM
T13520 18490-18506 UMLS/C1819444 denotes 7 production in
T13519 18197-18213 UMLS/C1819444 denotes IL-17 production
T13518 18023-18039 UMLS/C1819444 denotes IL-17 production
T13517 17917-17933 UMLS/C1819444 denotes IL-17 production
T13516 18752-18755 UP/P46108 denotes ibi
T13515 18687-18696 UMLS/C1546773 denotes on as wel
T13514 18833-18839 UMLS/C0441889 denotes (Fig.
T13513 18802-18809 UMLS/C0298346 denotes had no
T13512 18920-18924 UMLS/C1299351 denotes ncen
T13511 18072-18076 UMLS/C0205309 denotes know
T13510 18156-18167 UMLS/C1546944 denotes significant
T13509 18788-18797 UMLS/C0072980 denotes in and PD
T13508 18853-18861 UMLS/C0220825 denotes e the po
T13507 18957-18961 UMLS/C0178602 denotes spon
T13506 18746-18750 UMLS/C1370600 denotes 38 i
T13505 19237-19244 UMLS/C2348382 denotes on PBM
T13504 19204-19211 UMLS/C0449774 denotes of inh
T13503 19260-19268 UMLS/C0220806 denotes l inhibi
T13502 19103-19111 UMLS/C0220806 denotes l inhibi
T13501 19283-19295 UMLS/C1517004 denotes ental concen
T13500 17937-17967 UMLS/C1519313 denotes signal transduction inhibitors
T13499 19051-19065 UMLS/C1512045 denotes pendent inhibi
T13498 19269-19279 UMLS/C1999216 denotes ors at exp
T13497 19144-19154 UMLS/C1999216 denotes ors in add
T13496 19112-19122 UMLS/C1999216 denotes ors (Fig.
T13495 18756-18765 UMLS/C1999216 denotes or SB2035
T13494 18426-18435 UMLS/C1999216 denotes bitor of
T13493 18257-18266 UMLS/C1999216 denotes nhibitor,
T13492 18439-18443 UMLS/C1150481 denotes , al
T13491 18752-18755 UP/Q63768 denotes ibi
T13490 19316-19319 UMLS/C1518422 denotes erv
T13489 19129-19131 UMLS/C0450373 denotes e
T13488 19237-19244 UMLS/C1280500 denotes on PBM
T13487 18482-18489 UMLS/C0205263 denotes ced IL-
T13486 18189-18196 UMLS/C0205263 denotes induced
T13485 18277-18290 UMLS/C0011777 denotes examethasone
T13484 18611-18633 UP/O88480 denotes urin inhibitors cyclos
T13483 19158-19169 UMLS/C0332287 denotes n to PDTC a
T13482 18920-18924 UMLS/C0205250 denotes ncen
T13481 18752-18755 UMLS/C1833235 denotes ibi
T13480 18957-18961 UMLS/C1114758 denotes spon
T13479 18752-18755 UMLS/C1150588 denotes ibi
T13478 18652-18657 UMLS/C0729218 denotes lso d
T13477 19296-19310 UMLS/C0086045 denotes rations were n
T13476 18925-18939 UMLS/C0086045 denotes rations, we ob
T13475 18746-18750 UMLS/C1150579 denotes 38 i
T13474 18752-18755 UMLS/C1705633 denotes ibi
T13473 18168-18176 UMLS/C0547047 denotes decrease
T13472 18439-18443 UP/P42336 denotes , al
T13471 18920-18924 UMLS/C1561957 denotes ncen
T13470 18957-18961 UMLS/C0869039 denotes spon
T13469 19215-19225 UMLS/C1628982 denotes ion. Cytot
T13468 19066-19077 UMLS/C1628982 denotes ions of IL-
T13467 19000-19010 UMLS/C1628982 denotes ion of IL-
T13466 18894-18904 UMLS/C1628982 denotes ion by the
T13465 17903-17913 UMLS/C1628982 denotes Inhibition
T13464 18920-18924 UMLS/C1561958 denotes ncen
T13463 19179-19187 UMLS/C0251991 denotes 2 showed
T13462 18983-18991 UMLS/C0251991 denotes 2 for th
T13461 18395-18403 UMLS/C0251991 denotes 4002 and
T13460 18827-18832 UMLS/C1522571 denotes evels
T13459 18681-18686 UMLS/C1522571 denotes ecret
T13458 18168-18176 UMLS/C0205216 denotes decrease
T13457 18013-18022 UMLS/C0205217 denotes increased
T13456 19199-19203 UMLS/C1692345 denotes tter
T13455 18746-18750 UMLS/C1150553 denotes 38 i
T13454 19170-19174 UMLS/C0084183 denotes d LY
T13453 18974-18978 UMLS/C0084183 denotes d LY
T13452 18268-18272 UMLS/C0084183 denotes DTC
T13451 19248-19252 UMLS/C1321301 denotes the
T13450 19034-19038 UMLS/C1321301 denotes here
T13449 18513-18517 UMLS/C1321301 denotes (98
T13448 18046-18050 UMLS/C1321301 denotes PBMC
T13447 18827-18832 UMLS/C0384648 denotes evels
T13446 18681-18686 UMLS/C0384648 denotes ecret
T13445 18117-18125 UMLS/C1314939 denotes involved
T13444 18439-18443 UMLS/C1368105 denotes , al
T13443 19138-19143 UMLS/C1556044 denotes nhibi
T13442 18962-18970 UMLS/C1706817 denotes e of PDT
T13441 18814-18823 UMLS/C1301751 denotes ct on IL-
T13440 19227-19236 UMLS/C0677881 denotes ic effect
T13439 19269-19279 UMLS/C0243077 denotes ors at exp
T13438 19144-19154 UMLS/C0243077 denotes ors in add
T13437 19112-19122 UMLS/C0243077 denotes ors (Fig.
T13436 18756-18765 UMLS/C0243077 denotes or SB2035
T13435 18426-18435 UMLS/C0243077 denotes bitor of
T13434 18257-18266 UMLS/C0243077 denotes nhibitor,
T13433 18712-18744 UP/Q00859 denotes -activated protein kinase (MAPK)
T13432 18611-18633 UP/Q9Y6J0 denotes urin inhibitors cyclos
T13431 18912-18916 UMLS/C0013227 denotes hig
T13430 18962-18970 UMLS/C1704632 denotes e of PDT
T13429 18083-18111 UMLS/C0086982 denotes signal transduction pathways
T13428 19138-19143 UMLS/C1955473 denotes nhibi
T13427 18611-18633 UMLS/C1562036 denotes urin inhibitors cyclos
T13426 18752-18755 UP/Q9NV58 denotes ibi
T13425 18766-18774 UMLS/C0297666 denotes 0 did, w
T13424 18117-18125 UMLS/C1947935 denotes involved
T13423 18752-18755 UP/Q04929 denotes ibi
T13422 18700-18704 UMLS/C0205170 denotes the
T13421 18827-18832 UMLS/C1623218 denotes evels
T13420 18681-18686 UMLS/C1623218 denotes ecret
T13419 18439-18443 UMLS/C1705325 denotes , al
T13418 18408-18418 UMLS/C0078517 denotes mannin, as
T13417 18752-18755 UP/O97628 denotes ibi
T13416 19320-19328 UMLS/C1441672 denotes d (Fig.
T13415 18944-18952 UMLS/C1441672 denotes d the do
T13414 18218-18226 UMLS/C1441672 denotes observed
T13413 18000-18008 UMLS/C1441672 denotes observed
T13412 18746-18750 UMLS/C0752312 denotes 38 i
T13411 18712-18744 UMLS/C0752312 denotes -activated protein kinase (MAPK)
T13410 18920-18924 UMLS/C1522410 denotes ncen
T13409 19129-19131 UMLS/C1553636 denotes e
T13408 18319-18324 UMLS/C0439044 denotes lone
T13407 18168-18176 UMLS/C0392756 denotes decrease
T13406 19215-19225 UMLS/C0021467 denotes ion. Cytot
T13405 19066-19077 UMLS/C0021467 denotes ions of IL-
T13404 19000-19010 UMLS/C0021467 denotes ion of IL-
T13403 18894-18904 UMLS/C0021467 denotes ion by the
T13402 17903-17913 UMLS/C0021467 denotes Inhibition
T13401 19215-19225 UMLS/C0021469 denotes ion. Cytot
T13400 19066-19077 UMLS/C0021469 denotes ions of IL-
T13399 19000-19010 UMLS/C0021469 denotes ion of IL-
T13398 18894-18904 UMLS/C0021469 denotes ion by the
T13397 18459-18468 UMLS/C0021469 denotes bited the
T13396 17903-17913 UMLS/C0021469 denotes Inhibition
T13395 18439-18443 UMLS/C0285761 denotes , al
T13394 18850-18852 UMLS/C0319022 denotes ua
T13393 18069-18071 UMLS/C0319022 denotes to
T13392 18574-18579 UMLS/C0439297 denotes P < 0
T13391 18544-18549 UMLS/C0439297 denotes [P <
T13390 18363-18368 UMLS/C0439297 denotes l, re
T13389 19124-19127 UMLS/C0349966 denotes ).
T13388 18841-18844 UMLS/C0349966 denotes . T
T13387 18145-18148 UMLS/C0349966 denotes Fig
T13386 19227-19236 UMLS/C1511636 denotes ic effect
T13385 18168-18176 UMLS/C0442797 denotes decrease
T13384 18752-18755 UP/Q64010 denotes ibi
T13383 18013-18022 UMLS/C0442805 denotes increased
T13382 18687-18696 UMLS/C1327616 denotes on as wel
T13381 18013-18022 UMLS/C0442808 denotes increased
T13380 18881-18893 UMLS/C0205370 denotes cific inhibi
T13379 18687-18696 UMLS/C0036536 denotes on as wel
T13378 18450-18458 UMLS/C0522501 denotes edly inh
T13377 18156-18167 UMLS/C0750502 denotes significant
T13376 18687-18696 UMLS/C0036537 denotes on as wel
T13375 18752-18755 UMLS/C1412886 denotes ibi
T13374 19199-19203 UMLS/C0445247 denotes tter
T13373 18833-18839 UMLS/C0456079 denotes (Fig.
T13372 18752-18755 UMLS/C1366876 denotes ibi
T13371 18962-18970 UMLS/C0871261 denotes e of PDT
T13370 18294-18304 UMLS/C1707455 denotes omparison
T13369 18634-18647 UMLS/C0010592 denotes orin A and FK
T13368 18912-18916 UMLS/C1254351 denotes hig
T13367 19296-19310 UMLS/C1446561 denotes rations were n
T13366 18925-18939 UMLS/C1446561 denotes rations, we ob
T12596 17710-17715 UMLS/C1825592 denotes 17 pr
T12595 17594-17599 UMLS/C1825592 denotes 17 we
T12594 17438-17443 UMLS/C1825592 denotes IL-17
T12593 17234-17239 UMLS/C1825592 denotes IL-17
T12592 17393-17409 UMLS/C1819444 denotes IL-17 production
T12591 17220-17230 UMLS/C1548180 denotes production
T12590 17621-17623 UMLS/C0450353 denotes .
T12589 17818-17822 UMLS/C1546509 denotes as o
T12588 17473-17478 UMLS/C1149222 denotes IL-15
T12587 17584-17590 UMLS/C0441889 denotes els in
T12586 17444-17449 UMLS/C0441889 denotes level
T12585 17542-17547 UMLS/C1149225 denotes -18 (
T12584 17892-17897 UMLS/C0439275 denotes Fig.
T12583 17870-17875 UMLS/C0439275 denotes or MI
T12582 17850-17855 UMLS/C0439275 denotes , MIP
T12581 17673-17678 UMLS/C0439275 denotes ml),
T12580 17654-17659 UMLS/C0439275 denotes ml) o
T12579 17573-17578 UMLS/C0439275 denotes ml) t
T12578 17552-17557 UMLS/C0439275 denotes /ml)
T12577 17534-17539 UMLS/C0439275 denotes /ml),
T12576 17515-17520 UMLS/C0439275 denotes g/ml)
T12575 17483-17488 UMLS/C0439275 denotes ng/ml
T12574 17818-17822 UMLS/C1547191 denotes as o
T12573 17681-17692 UMLS/C1546944 denotes nificant up
T12572 17473-17478 UMLS/C0254610 denotes IL-15
T12571 17257-17265 UMLS/C0220825 denotes evaluate
T12570 17664-17668 UMLS/C1149241 denotes 6 (1
T12569 17196-17201 UMLS/C0454788 denotes might
T12568 17450-17455 UMLS/C0231290 denotes after
T12567 17196-17201 UMLS/C0337876 denotes might
T12566 17818-17822 UMLS/C1556146 denotes as o
T12565 17346-17353 UMLS/C2348382 denotes effects
T12564 17270-17277 UMLS/C2348382 denotes effects
T12563 17818-17822 UMLS/C1556147 denotes as o
T12562 17818-17822 UMLS/C1556148 denotes as o
T12561 17818-17822 UMLS/C1556150 denotes as o
T12560 17818-17822 UMLS/C1556151 denotes as o
T12559 17818-17822 UMLS/C1556152 denotes as o
T12558 17069-17076 UMLS/C0332257 denotes include
T12557 17085-17095 UMLS/C0449475 denotes cell types
T12556 17162-17173 UMLS/C0024432 denotes macrophages
T12555 17414-17422 UMLS/C1511790 denotes detected
T12554 17316-17325 UMLS/C1879547 denotes activated
T12553 17085-17095 UMLS/C0007634 denotes cell types
T12552 17379-17389 UMLS/C0282554 denotes chemokines
T12551 17042-17052 UMLS/C0282554 denotes chemokines
T12550 17818-17822 UMLS/C1553523 denotes as o
T12549 17473-17478 UMLS/C1334105 denotes IL-15
T12548 17346-17353 UMLS/C1280500 denotes effects
T12547 17270-17277 UMLS/C1280500 denotes effects
T12546 17664-17668 UMLS/C1527132 denotes 6 (1
T12545 17069-17076 UMLS/C2700399 denotes include
T12544 17304-17312 UMLS/C1963578 denotes released
T12543 17148-17156 UMLS/C1963578 denotes released
T12542 17099-17110 UMLS/C0332287 denotes addition to
T12541 17304-17312 UMLS/C0439180 denotes released
T12540 17148-17156 UMLS/C0439180 denotes released
T12539 17631-17643 UMLS/C0332293 denotes ated with MC
T12538 17542-17547 UMLS/C1334109 denotes -18 (
T12537 17304-17312 UMLS/C0680255 denotes released
T12536 17148-17156 UMLS/C0680255 denotes released
T12535 17207-17215 UMLS/C0001721 denotes affected
T12534 17414-17422 UMLS/C0442726 denotes detected
T12533 17162-17173 UMLS/C1546706 denotes macrophages
T12532 17184-17195 UMLS/C1546705 denotes lymphocytes
T12531 17542-17547 UMLS/C1527127 denotes -18 (
T12530 17456-17467 UMLS/C1948023 denotes stimulation
T12529 17450-17455 UMLS/C0687676 denotes after
T12528 17184-17195 UMLS/C2697913 denotes lymphocytes
T12527 17644-17649 UMLS/C1522558 denotes -1 (1
T12526 17841-17845 UMLS/C1149173 denotes 10 n
T12525 17693-17706 UMLS/C0041904 denotes egulations of
T12524 17184-17195 UMLS/C0200635 denotes lymphocytes
T12523 17841-17845 UMLS/C1527432 denotes 10 n
T12522 17365-17374 UMLS/C1524094 denotes cytokines
T12521 17294-17303 UMLS/C1524094 denotes cytokines
T12520 17138-17147 UMLS/C1524094 denotes cytokines
T12519 17028-17037 UMLS/C1524094 denotes cytokines
T12518 17664-17668 UMLS/C0021760 denotes 6 (1
T12517 17710-17715 UMLS/C1522571 denotes 17 pr
T12516 17594-17599 UMLS/C1522571 denotes 17 we
T12515 17438-17443 UMLS/C1522571 denotes IL-17
T12514 17234-17239 UMLS/C1522571 denotes IL-17
T12513 17426-17434 UMLS/C0205217 denotes increase
T12512 17456-17467 UMLS/C1292856 denotes stimulation
T12511 17184-17195 UMLS/C0024264 denotes lymphocytes
T12510 17664-17668 UMLS/C1334122 denotes 6 (1
T12509 17644-17649 UMLS/C1705079 denotes -1 (1
T12508 17326-17330 UMLS/C1321301 denotes PBMC
T12507 17064-17068 UMLS/C1321301 denotes PBMC
T12506 17007-17011 UMLS/C1321301 denotes PBMC
T12505 17710-17715 UMLS/C0384648 denotes 17 pr
T12504 17594-17599 UMLS/C0384648 denotes 17 we
T12503 17438-17443 UMLS/C0384648 denotes IL-17
T12502 17234-17239 UMLS/C0384648 denotes IL-17
T12501 17207-17215 UMLS/C1314939 denotes affected
T12500 17841-17845 UMLS/C0079633 denotes 10 n
T12499 17335-17341 UMLS/C0022885 denotes tested
T12498 17178-17183 UMLS/C1556044 denotes other
T12497 17335-17341 UMLS/C0013702 denotes tested
T12496 17716-17724 UMLS/C0033684 denotes teins we
T12495 17644-17649 UMLS/C1337092 denotes -1 (1
T12494 17605-17614 UMLS/C0442739 denotes hanged (F
T12493 17178-17183 UMLS/C1955473 denotes other
T12492 17818-17822 UMLS/C1550083 denotes as o
T12491 17335-17341 UMLS/C0039593 denotes tested
T12490 17162-17173 UMLS/C1550652 denotes macrophages
T12489 17184-17195 UMLS/C1550651 denotes lymphocytes
T12488 17710-17715 UMLS/C1623218 denotes 17 pr
T12487 17594-17599 UMLS/C1623218 denotes 17 we
T12486 17438-17443 UMLS/C1623218 denotes IL-17
T12485 17234-17239 UMLS/C1623218 denotes IL-17
T12484 17069-17076 UMLS/C1552866 denotes include
T12483 17818-17822 UMLS/C1706277 denotes as o
T12482 17827-17835 UMLS/C1441672 denotes ed with
T12481 17730-17738 UMLS/C1441672 denotes erved (6
T12480 17841-17845 UMLS/C1705592 denotes 10 n
T12479 17335-17341 UMLS/C0392366 denotes tested
T12478 17542-17547 UMLS/C0383327 denotes -18 (
T12477 17605-17614 UMLS/C2346711 denotes hanged (F
T12476 17304-17312 UMLS/C1283071 denotes released
T12475 17148-17156 UMLS/C1283071 denotes released
T12474 17818-17822 UMLS/C1550437 denotes as o
T12473 17254-17256 UMLS/C0319022 denotes To
T12472 17207-17215 UMLS/C0392760 denotes affected
T12471 17335-17341 UMLS/C0183885 denotes tested
T12470 17379-17389 UMLS/C1527036 denotes chemokines
T12469 17042-17052 UMLS/C1527036 denotes chemokines
T12468 17778-17783 UMLS/C0439297 denotes resp
T12467 17616-17619 UMLS/C0349966 denotes . 2
T12466 17621-17623 UMLS/C1553634 denotes .
T12465 16970-17000 UMLS/C1819484 denotes Regulation of IL-17 production
T12464 17281-17293 UMLS/C0333348 denotes inflammatory
T12463 17125-17137 UMLS/C0333348 denotes inflammatory
T12462 17015-17027 UMLS/C0333348 denotes inflammatory
T12461 17426-17434 UMLS/C0442805 denotes increase
T12460 17841-17845 UMLS/C1366571 denotes 10 n
T12459 17245-17252 UMLS/C0039194 denotes T cells
T12458 17111-17118 UMLS/C0039194 denotes T cells
T12457 17426-17434 UMLS/C0442808 denotes increase
T12456 17681-17692 UMLS/C0750502 denotes nificant up
T12455 17584-17590 UMLS/C0456079 denotes els in
T12454 17444-17449 UMLS/C0456079 denotes level
T12453 17304-17312 UMLS/C0391871 denotes released
T12452 17148-17156 UMLS/C0391871 denotes released
T12451 17365-17374 UMLS/C0079189 denotes cytokines
T12450 17294-17303 UMLS/C0079189 denotes cytokines
T12449 17138-17147 UMLS/C0079189 denotes cytokines
T12448 17028-17037 UMLS/C0079189 denotes cytokines
T12447 17818-17822 UMLS/C0549184 denotes as o
T12446 17818-17822 UMLS/C1551387 denotes as o
T11760 16737-16750 UMLS/C0332232 denotes proximately 1
T11759 16158-16166 UMLS/C1578479 denotes patients
T11758 16511-16515 UMLS/C0323983 denotes his,
T11757 16478-16482 UMLS/C1511726 denotes ata
T11756 16730-16735 UMLS/C1825592 denotes -17 (
T11755 16464-16469 UMLS/C1825592 denotes L-17
T11754 16221-16226 UMLS/C1825592 denotes IL-17
T11753 16158-16166 UMLS/C1578483 denotes patients
T11752 16858-16874 UMLS/C1819444 denotes -17 production w
T11751 16637-16653 UMLS/C1819444 denotes -17 production u
T11750 16130-16146 UMLS/C1819444 denotes IL-17 production
T11749 16158-16166 UMLS/C1578480 denotes patients
T11748 16158-16166 UMLS/C1578481 denotes patients
T11747 16158-16166 UMLS/C1578486 denotes patients
T11746 16158-16166 UMLS/C1578484 denotes patients
T11745 16158-16166 UMLS/C1578485 denotes patients
T11744 16843-16846 UMLS/C0030779 denotes A,
T11743 16209-16212 UMLS/C0030779 denotes PHA
T11742 16470-16476 UMLS/C0441889 denotes evels
T11741 16250-16257 UMLS/C1279919 denotes earlier
T11740 16239-16244 UMLS/C0205309 denotes known
T11739 16403-16420 UMLS/C1155065 denotes cell activation,
T11738 16313-16325 UMLS/C1292732 denotes investigated
T11737 16330-16336 UMLS/C2348382 denotes effect
T11736 16158-16166 UMLS/C1550655 denotes patients
T11735 16804-16813 UMLS/C1439852 denotes cubated w
T11734 16879-16883 UMLS/C0205172 denotes re p
T11733 16725-16729 UMLS/C0205172 denotes re I
T11732 16730-16735 UMLS/C1623218 denotes -17 (
T11731 16464-16469 UMLS/C1623218 denotes L-17
T11730 16221-16226 UMLS/C1623218 denotes IL-17
T11729 16437-16451 UMLS/C1512045 denotes ose-dependent
T11728 16826-16834 UMLS/C0026249 denotes togens s
T11727 16291-16300 UMLS/C1879547 denotes activated
T11726 16483-16486 UMLS/C1518422 denotes ot
T11725 16843-16846 UMLS/C0031858 denotes A,
T11724 16209-16212 UMLS/C0031858 denotes PHA
T11723 16520-16525 UMLS/C1707391 denotes hose
T11722 16158-16166 UMLS/C1705908 denotes patients
T11721 16779-16784 UMLS/C0439044 denotes one.
T11720 16330-16336 UMLS/C1280500 denotes effect
T11719 16678-16689 UMLS/C1947911 denotes mbination o
T11718 16879-16883 UMLS/C0439064 denotes re p
T11717 16725-16729 UMLS/C0439064 denotes re I
T11716 16826-16834 UMLS/C0018284 denotes togens s
T11715 16266-16268 UMLS/C0319022 denotes to
T11714 16258-16265 UMLS/C1709908 denotes reports
T11713 16553-16566 UMLS/C0086045 denotes ncentration f
T11712 16350-16364 UMLS/C0086045 denotes concentrations
T11711 16541-16552 UMLS/C1948023 denotes imulation c
T11710 16955-16960 UMLS/C0439297 denotes l; P
T11709 16848-16857 UMLS/C0442805 denotes creased I
T11708 16452-16460 UMLS/C0442805 denotes ncrease
T11707 16120-16129 UMLS/C0442805 denotes Increased
T11706 16654-16659 UMLS/C0547043 denotes to 3
T11705 16819-16825 UMLS/C0039194 denotes cell m
T11704 16301-16308 UMLS/C0039194 denotes T cells
T11703 16848-16857 UMLS/C0442808 denotes creased I
T11702 16452-16460 UMLS/C0442808 denotes ncrease
T11701 16120-16129 UMLS/C0442808 denotes Increased
T11700 16258-16265 UMLS/C0700287 denotes reports
T11699 16502-16507 UMLS/C1527178 denotes asis
T11698 16593-16598 UMLS/C0039224 denotes ble 1
T11697 16730-16735 UMLS/C1522571 denotes -17 (
T11696 16464-16469 UMLS/C1522571 denotes L-17
T11695 16221-16226 UMLS/C1522571 denotes IL-17
T11694 16158-16166 UMLS/C0030705 denotes patients
T11693 16848-16857 UMLS/C0205217 denotes creased I
T11692 16452-16460 UMLS/C0205217 denotes ncrease
T11691 16120-16129 UMLS/C0205217 denotes Increased
T11690 16541-16552 UMLS/C1292856 denotes imulation c
T11689 16470-16476 UMLS/C0456079 denotes evels
T11688 16678-16689 UMLS/C0453882 denotes mbination o
T11687 16678-16689 UMLS/C0205195 denotes mbination o
T11686 16340-16349 UMLS/C1705242 denotes different
T11685 16150-16154 UMLS/C1321301 denotes PBMC
T11684 16553-16566 UMLS/C1446561 denotes ncentration f
T11683 16350-16364 UMLS/C1446561 denotes concentrations
T11682 16593-16598 UMLS/C1706073 denotes ble 1
T11681 16593-16598 UMLS/C1706074 denotes ble 1
T11680 16730-16735 UMLS/C0384648 denotes -17 (
T11679 16464-16469 UMLS/C0384648 denotes L-17
T11678 16221-16226 UMLS/C0384648 denotes IL-17
T11219 15657-15665 UMLS/C1578479 denotes atients
T11218 15639-15647 UMLS/C1578479 denotes atients
T11217 15541-15549 UMLS/C1578479 denotes patients
T11216 15523-15531 UMLS/C1578479 denotes patients
T11215 15810-15815 UMLS/C1825592 denotes L-17
T11214 15708-15713 UMLS/C1825592 denotes L-17
T11213 15657-15665 UMLS/C1578483 denotes atients
T11212 15639-15647 UMLS/C1578483 denotes atients
T11211 15541-15549 UMLS/C1578483 denotes patients
T11210 15523-15531 UMLS/C1578483 denotes patients
T11209 15939-15955 UMLS/C1819444 denotes 7 production sti
T11208 15493-15509 UMLS/C1819444 denotes IL-17 production
T11207 15657-15665 UMLS/C1578480 denotes atients
T11206 15639-15647 UMLS/C1578480 denotes atients
T11205 15541-15549 UMLS/C1578480 denotes patients
T11204 15523-15531 UMLS/C1578480 denotes patients
T11203 15657-15665 UMLS/C1578481 denotes atients
T11202 15639-15647 UMLS/C1578481 denotes atients
T11201 15541-15549 UMLS/C1578481 denotes patients
T11200 15523-15531 UMLS/C1578481 denotes patients
T11199 15657-15665 UMLS/C1578486 denotes atients
T11198 15639-15647 UMLS/C1578486 denotes atients
T11197 15541-15549 UMLS/C1578486 denotes patients
T11196 15523-15531 UMLS/C1578486 denotes patients
T11195 15731-15741 UMLS/C0521095 denotes etermined
T11194 15657-15665 UMLS/C1578484 denotes atients
T11193 15639-15647 UMLS/C1578484 denotes atients
T11192 15541-15549 UMLS/C1578484 denotes patients
T11191 15523-15531 UMLS/C1578484 denotes patients
T11190 15657-15665 UMLS/C1578485 denotes atients
T11189 15639-15647 UMLS/C1578485 denotes atients
T11188 15541-15549 UMLS/C1578485 denotes patients
T11187 15523-15531 UMLS/C1578485 denotes patients
T11186 16036-16044 UMLS/C2587213 denotes rols (76
T11185 15970-15973 UMLS/C0030779 denotes was
T11184 15619-15622 UMLS/C0030779 denotes PHA
T11183 15816-15825 UMLS/C1546773 denotes ecretion
T11182 15714-15720 UMLS/C0441889 denotes evels
T11181 15992-15998 UMLS/C1299351 denotes er in
T11180 15757-15769 UMLS/C1550101 denotes upernatants
T11179 15749-15756 UMLS/C0220814 denotes ulture
T11178 15605-15613 UMLS/C0220814 denotes cultured
T11177 15562-15568 UMLS/C0205307 denotes normal
T11176 15793-15800 UMLS/C1265611 denotes mounts
T11175 15591-15600 UMLS/C0086972 denotes separated
T11174 15793-15800 UMLS/C1561574 denotes mounts
T11173 15569-15580 UMLS/C1550471 denotes individuals
T11172 15657-15665 UMLS/C1550655 denotes atients
T11171 15639-15647 UMLS/C1550655 denotes atients
T11170 15541-15549 UMLS/C1550655 denotes patients
T11169 15523-15531 UMLS/C1550655 denotes patients
T11168 15810-15815 UMLS/C1623218 denotes L-17
T11167 15708-15713 UMLS/C1623218 denotes L-17
T11166 15749-15756 UMLS/C0010453 denotes ulture
T11165 15605-15613 UMLS/C0010453 denotes cultured
T11164 15831-15834 UMLS/C1518422 denotes ot
T11163 15970-15973 UMLS/C0031858 denotes was
T11162 15619-15622 UMLS/C0031858 denotes PHA
T11161 16036-16044 UMLS/C1547100 denotes rols (76
T11160 15591-15600 UMLS/C1881713 denotes separated
T11159 15992-15998 UMLS/C1522410 denotes er in
T11158 16036-16044 UMLS/C0332298 denotes rols (76
T11157 15657-15665 UMLS/C1705908 denotes atients
T11156 15639-15647 UMLS/C1705908 denotes atients
T11155 15541-15549 UMLS/C1705908 denotes patients
T11154 15523-15531 UMLS/C1705908 denotes patients
T11153 15591-15600 UMLS/C0443299 denotes separated
T11152 15562-15568 UMLS/C1873497 denotes normal
T11151 15992-15998 UMLS/C0205250 denotes er in
T11150 15562-15568 UMLS/C1704701 denotes normal
T11149 15562-15568 UMLS/C2347086 denotes normal
T11148 15562-15568 UMLS/C1550457 denotes normal
T11147 15956-15966 UMLS/C1948023 denotes ulated by
T11146 16106-16111 UMLS/C0439297 denotes P < 0
T11145 16075-16080 UMLS/C0439297 denotes [P <
T11144 15913-15918 UMLS/C0439297 denotes l, re
T11143 15771-15774 UMLS/C0349966 denotes ig.
T11142 15749-15756 UMLS/C2242979 denotes ulture
T11141 15605-15613 UMLS/C2242979 denotes cultured
T11140 16036-16044 UMLS/C0009932 denotes rols (76
T11139 15816-15825 UMLS/C1327616 denotes ecretion
T11138 15992-15998 UMLS/C1561957 denotes er in
T11137 15992-15998 UMLS/C1561958 denotes er in
T11136 15864-15879 UMLS/C2705716 denotes ormal controls
T11135 15691-15706 UMLS/C2705716 denotes ormal controls;
T11134 15816-15825 UMLS/C0036536 denotes ecretion
T11133 15810-15815 UMLS/C1522571 denotes L-17
T11132 15708-15713 UMLS/C1522571 denotes L-17
T11131 15657-15665 UMLS/C0030705 denotes atients
T11130 15639-15647 UMLS/C0030705 denotes atients
T11129 15541-15549 UMLS/C0030705 denotes patients
T11128 15523-15531 UMLS/C0030705 denotes patients
T11127 15816-15825 UMLS/C0036537 denotes ecretion
T11126 15804-15809 UMLS/C0205112 denotes asal
T11125 15562-15568 UMLS/C1551394 denotes normal
T11124 15714-15720 UMLS/C0456079 denotes evels
T11123 15749-15756 UMLS/C0430400 denotes ulture
T11122 15605-15613 UMLS/C0430400 denotes cultured
T11121 15835-15844 UMLS/C1705242 denotes ifferent
T11120 16036-16044 UMLS/C1550141 denotes rols (76
T11119 15562-15568 UMLS/C0439166 denotes normal
T11118 16005-16009 UMLS/C1321301 denotes tha
T11117 15581-15585 UMLS/C1321301 denotes PBMC
T11116 15513-15517 UMLS/C1321301 denotes PBMC
T11115 16036-16044 UMLS/C1882979 denotes rols (76
T11114 16036-16044 UMLS/C0243148 denotes rols (76
T11113 15810-15815 UMLS/C0384648 denotes L-17
T11112 15708-15713 UMLS/C0384648 denotes L-17
T11013 15416-15423 UMLS/C0336766 denotes atched
T11012 15328-15337 UMLS/C0017262 denotes expressed
T11011 15367-15375 UMLS/C0002778 denotes nalysis
T11010 15310-15318 UMLS/C0002778 denotes analysis
T11009 15319-15323 UMLS/C1511726 denotes Data
T11008 15341-15346 UMLS/C0444504 denotes means
T11007 15424-15429 UMLS/C1709450 denotes airs.
T11006 15350-15353 UMLS/C0432222 denotes EM.
T11005 15341-15346 UMLS/C2348143 denotes means
T11004 15380-15389 UMLS/C1550369 denotes erformed
T11003 15341-15346 UMLS/C0876919 denotes means
T11002 15431-15439 UMLS/C1709380 denotes values
T11001 15471-15482 UMLS/C1546944 denotes ignificant.
T11000 15367-15375 UMLS/C0936012 denotes nalysis
T10999 15310-15318 UMLS/C0936012 denotes analysis
T10998 15328-15337 UMLS/C1171362 denotes expressed
T10997 15405-15411 UMLS/C0871472 denotes -test
T10996 15328-15337 UMLS/C1515670 denotes expressed
T10995 15380-15389 UMLS/C0884358 denotes erformed
T10994 15416-15423 UMLS/C1708943 denotes atched
T10993 15367-15375 UMLS/C1524024 denotes nalysis
T10992 15310-15318 UMLS/C1524024 denotes analysis
T10991 15341-15346 UMLS/C2347634 denotes means
T10990 15355-15366 UMLS/C0038215 denotes tatistical
T10989 15298-15309 UMLS/C0038215 denotes Statistical
T10988 15471-15482 UMLS/C0750502 denotes ignificant.
T10987 15395-15404 UMLS/C0038492 denotes tudent's
T10986 15350-15353 UMLS/C0262878 denotes EM.
T10985 15341-15346 UMLS/C1704970 denotes means
T10770 15231-15237 UMLS/C0449788 denotes umber
T10769 15122-15130 UMLS/C1442770 denotes 24 hours
T10768 15024-15026 UMLS/C0319022 denotes to
T10767 15122-15130 UMLS/C0456696 denotes 24 hours
T10766 15122-15130 UMLS/C0439584 denotes 24 hours
T10765 15101-15106 UMLS/C0687676 denotes After
T10764 15107-15117 UMLS/C1979572 denotes incubation
T10763 15165-15175 UMLS/C1549488 denotes percentage
T10762 15060-15069 UMLS/C1511636 denotes cytotoxic
T10761 15008-15014 UMLS/C0025664 denotes method
T10760 15008-15014 UMLS/C0025663 denotes method
T10759 15147-15156 UMLS/C1512335 denotes harvested
T10758 15215-15222 UMLS/C1705501 denotes formula
T10757 14970-14976 UMLS/C0005507 denotes assays
T10756 14944-14949 UMLS/C0005507 denotes assay
T10755 15165-15175 UMLS/C0439165 denotes percentage
T10754 15040-15049 UMLS/C0035647 denotes potential
T10821 15285-15290 UMLS/C1704653 denotes ells)
T10820 15136-15141 UMLS/C1704653 denotes cells
T10819 15094-15099 UMLS/C1704653 denotes cells
T10818 15008-15014 UMLS/C0449851 denotes method
T10817 15165-15175 UMLS/C1561533 denotes percentage
T10816 15053-15059 UMLS/C1552596 denotes direct
T10815 15231-15237 UMLS/C1709287 denotes umber
T10814 15241-15253 UMLS/C1441322 denotes iable cells/
T10813 15107-15117 UMLS/C1980044 denotes incubation
T10812 15248-15260 UMLS/C0007584 denotes ells/number
T10811 15060-15069 UMLS/C0677881 denotes cytotoxic
T10810 15080-15090 UMLS/C0243077 denotes inhibitors
T10809 14970-14976 UMLS/C0243073 denotes assays
T10808 14944-14949 UMLS/C0243073 denotes assay
T10807 15269-15275 UMLS/C0443348 denotes iable
T10806 15027-15035 UMLS/C0220825 denotes evaluate
T10805 15195-15205 UMLS/C1443182 denotes calculated
T10804 15285-15290 UMLS/C1136359 denotes ells)
T10803 15136-15141 UMLS/C1136359 denotes cells
T10802 15094-15099 UMLS/C1136359 denotes cells
T10801 14970-14976 UMLS/C1510438 denotes assays
T10800 14944-14949 UMLS/C1510438 denotes assay
T10799 15101-15106 UMLS/C0231290 denotes After
T10798 15070-15076 UMLS/C2348382 denotes effect
T10797 14982-14993 UMLS/C0041213 denotes trypan blue
T10796 14918-14929 UMLS/C0041213 denotes Trypan blue
T10795 14994-14997 UMLS/C0013343 denotes dye
T10794 14930-14933 UMLS/C0013343 denotes dye
T10793 15053-15059 UMLS/C0439851 denotes direct
T10792 15053-15059 UMLS/C1947931 denotes direct
T10791 15285-15290 UMLS/C1948049 denotes ells)
T10790 15136-15141 UMLS/C1948049 denotes cells
T10789 15094-15099 UMLS/C1948049 denotes cells
T10788 15080-15090 UMLS/C1999216 denotes inhibitors
T10787 15231-15237 UMLS/C1554106 denotes umber
T10786 15285-15290 UMLS/C0007634 denotes ells)
T10785 15136-15141 UMLS/C0007634 denotes cells
T10784 15094-15099 UMLS/C0007634 denotes cells
T10783 15285-15290 UMLS/C1269647 denotes ells)
T10782 15136-15141 UMLS/C1269647 denotes cells
T10781 15094-15099 UMLS/C1269647 denotes cells
T10780 15176-15190 UMLS/C0007620 denotes cell viability
T10779 14955-14969 UMLS/C0007620 denotes cell viability
T10778 14902-14916 UMLS/C0007620 denotes Cell viability
T10777 15070-15076 UMLS/C1280500 denotes effect
T10776 15231-15237 UMLS/C0237753 denotes umber
T10775 15195-15205 UMLS/C1441506 denotes calculated
T10774 15195-15205 UMLS/C0444686 denotes calculated
T10773 15215-15222 UMLS/C0489829 denotes formula
T10772 14998-15007 UMLS/C0680251 denotes exclusion
T10771 14934-14943 UMLS/C0680251 denotes exclusion
T10176 14682-14686 UMLS/C0972569 denotes e dr
T10175 13754-13757 UMLS/C0972569 denotes Gel
T10174 13933-13938 UMLS/C1825592 denotes 17 pr
T10173 14834-14837 UP/Q28618 denotes nd
T10172 14547-14554 UMLS/C2347026 denotes were s
T10171 14772-14779 UMLS/C0430054 denotes Rabbit
T10170 14839-14842 UP/P21707 denotes Rel
T10169 14839-14842 UP/P46096 denotes Rel
T10168 14839-14842 UP/P21579 denotes Rel
T10167 14772-14779 UMLS/C1710031 denotes Rabbit
T10166 14547-14554 UMLS/C0870078 denotes were s
T10165 14874-14887 UMLS/C0005574 denotes ogy (Santa Cr
T10164 14573-14588 UMLS/C0013855 denotes phoresis on non
T10163 14480-14488 UMLS/C0017861 denotes ol, 1 mg
T10162 13956-13959 UMLS/C0175754 denotes TG
T10161 14609-14628 UMLS/C0071500 denotes ylamide gels in 0.5
T10160 14527-14529 UMLS/C0439212 denotes po
T10159 14315-14317 UMLS/C0439212 denotes 00
T10158 14013-14021 UMLS/C1708632 denotes eling of
T10157 14085-14087 UMLS/C1235738 denotes ol
T10156 14498-14501 UP/P02769 denotes .2%
T10155 14231-14247 UMLS/C1518434 denotes ear extracts (2
T10154 14516-14519 UMLS/C1419038 denotes d 5
T10153 14171-14176 UMLS/C1442917 denotes e pur
T10152 14177-14189 UMLS/C0243114 denotes fication col
T10151 14013-14021 UMLS/C1705425 denotes eling of
T10150 14839-14842 UMLS/C1335610 denotes Rel
T10149 14013-14021 UMLS/C1705424 denotes eling of
T10148 14379-14386 UMLS/C0243122 denotes g buffe
T10147 14788-14809 UMLS/C0312586 denotes l antibodies against
T10146 14692-14697 UMLS/C1512080 denotes der v
T10145 13927-13932 UMLS/C0020156 denotes an IL
T10144 13802-13818 UMLS/C0028589 denotes uclear proteins
T10143 14692-14697 UMLS/C0011682 denotes der v
T10142 14692-14697 UMLS/C0205222 denotes der v
T10141 13907-13919 UMLS/C0005456 denotes ding site of
T10140 13789-13801 UMLS/C0005456 denotes inding site
T10139 14895-14899 UMLS/C0205203 denotes USA)
T10138 14869-14873 UMLS/C0205203 denotes chno
T10137 13773-13778 UMLS/C0005507 denotes assay
T10136 14135-14146 UMLS/C0028630 denotes eotides wer
T10135 14171-14176 UMLS/C2347609 denotes e pur
T10134 14300-14310 UMLS/C0012893 denotes robes (10
T10133 14704-14710 UMLS/C2712992 denotes nd exp
T10132 14498-14501 UMLS/C0487992 denotes .2%
T10131 13854-13858 UMLS/C1321301 denotes MC.
T10130 14387-14393 UMLS/C0006353 denotes consi
T10129 14839-14842 UP/P48018 denotes Rel
T10128 13824-13833 UMLS/C1705851 denotes xtracted
T10127 14692-14697 UMLS/C1550118 denotes der v
T10126 14152-14159 UMLS/C0849355 denotes ved by
T10125 14480-14488 UMLS/C0768477 denotes ol, 1 mg
T10124 14834-14837 UMLS/C1539081 denotes nd
T10123 13976-13979 UMLS/C0271742 denotes TT
T10122 13964-13967 UMLS/C0271742 denotes TA
T10121 14560-14569 UMLS/C2349001 denotes ed to ele
T10120 14527-14529 UMLS/C0694637 denotes po
T10119 14315-14317 UMLS/C0694637 denotes 00
T10118 14190-14197 UMLS/C1185738 denotes mns (St
T10117 14839-14842 UMLS/C1420556 denotes Rel
T10116 14085-14087 UMLS/C0040165 denotes ol
T10115 14847-14852 UMLS/C0035018 denotes from
T10114 14639-14662 UMLS/C0146923 denotes ate-EDTA buffer (pH 8.0
T10113 14839-14842 UMLS/C0599933 denotes Rel
T10112 14272-14281 UMLS/C1439852 denotes ated with
T10111 14698-14703 UMLS/C0542339 denotes cuum
T10110 14013-14021 UMLS/C1522485 denotes eling of
T10109 14379-14386 UMLS/C1689898 denotes g buffe
T10108 14839-14842 UP/P21521 denotes Rel
T10107 14339-14345 UMLS/C0456693 denotes n at r
T10106 14704-14710 UMLS/C0042221 denotes nd exp
T10105 14171-14176 UMLS/C0419358 denotes e pur
T10104 14211-14219 UMLS/C1555265 denotes olla, CA
T10103 14516-14519 UMLS/C1412528 denotes d 5
T10102 14508-14515 UMLS/C0068940 denotes t P40 a
T10101 13824-13833 UMLS/C1555707 denotes xtracted
T10100 14547-14554 UMLS/C0441621 denotes were s
T10099 14664-14666 UMLS/C0020283 denotes at
T10098 14424-14426 UMLS/C0020283 denotes ,
T10097 14739-14743 UMLS/C0086296 denotes -70°
T10096 14190-14197 UMLS/C1705246 denotes mns (St
T10095 14560-14569 UMLS/C1550501 denotes ed to ele
T10094 14516-14519 UMLS/C0050854 denotes d 5
T10093 14339-14345 UMLS/C1442458 denotes n at r
T10092 13907-13919 UMLS/C0682969 denotes ding site of
T10091 13789-13801 UMLS/C0682969 denotes inding site
T10090 14664-14666 UMLS/C1304686 denotes at
T10089 14424-14426 UMLS/C1304686 denotes ,
T10088 14839-14842 UP/P47191 denotes Rel
T10087 14516-14519 UP/P24653 denotes d 5
T10086 14772-14779 UMLS/C0199230 denotes Rabbit
T10085 14287-14299 UMLS/C2347885 denotes labeled DNA
T10084 13773-13778 UMLS/C1510438 denotes assay
T10083 14471-14475 UMLS/C0558745 denotes 5% g
T10082 13824-13833 UMLS/C0185115 denotes xtracted
T10081 14834-14837 UP/P83939 denotes nd
T10080 14772-14779 UMLS/C1698960 denotes Rabbit
T10079 14516-14519 UP/Q9WU34 denotes d 5
T10078 13860-13882 UMLS/C0028952 denotes igonucleotide probes e
T10077 14013-14021 UMLS/C0181496 denotes eling of
T10076 14498-14501 UMLS/C0005902 denotes .2%
T10075 14772-14779 UMLS/C1305399 denotes Rabbit
T10074 14834-14837 UMLS/C1417708 denotes nd
T10073 14682-14686 UMLS/C1382104 denotes e dr
T10072 13754-13757 UMLS/C1382104 denotes Gel
T10071 14547-14554 UMLS/C0370003 denotes were s
T10070 14664-14666 UMLS/C0031526 denotes at
T10069 14424-14426 UMLS/C0031526 denotes ,
T10068 14772-14779 UMLS/C1705053 denotes Rabbit
T10067 14664-14666 UMLS/C2363150 denotes at
T10066 14424-14426 UMLS/C2363150 denotes ,
T10065 14772-14779 UMLS/C0220908 denotes Rabbit
T10064 13956-13959 UMLS/C0282160 denotes TG
T10063 14772-14779 UMLS/C0220909 denotes Rabbit
T10062 14287-14299 UMLS/C1527121 denotes labeled DNA
T10061 14692-14697 UMLS/C1550582 denotes der v
T10060 14664-14666 UMLS/C0450409 denotes at
T10059 14424-14426 UMLS/C0450409 denotes ,
T10058 14664-14666 UMLS/C0450408 denotes at
T10057 14424-14426 UMLS/C0450408 denotes ,
T10056 14664-14666 UMLS/C0450407 denotes at
T10055 14424-14426 UMLS/C0450407 denotes ,
T10054 13972-13975 UMLS/C1414543 denotes AA
T10053 13968-13971 UMLS/C0040405 denotes CC
T10052 14171-14176 UMLS/C0728863 denotes e pur
T10051 14498-14501 UMLS/C0036774 denotes .2%
T10050 13933-13938 UMLS/C1522571 denotes 17 pr
T10049 14177-14189 UMLS/C1998793 denotes fication col
T10048 14560-14569 UMLS/C1706203 denotes ed to ele
T10047 14516-14519 UMLS/C1334127 denotes d 5
T10046 14498-14501 UMLS/C1511233 denotes .2%
T10045 13933-13938 UMLS/C0384648 denotes 17 pr
T10044 14085-14087 UMLS/C1281902 denotes ol
T10043 14682-14686 UMLS/C0017243 denotes e dr
T10042 13754-13757 UMLS/C0017243 denotes Gel
T10041 14781-14787 UMLS/C1446777 denotes lyclon
T10040 14029-14041 UMLS/C1883001 denotes se strand wi
T10039 13976-13979 UP/P05067 denotes TT
T10038 13964-13967 UP/P05067 denotes TA
T10037 13773-13778 UMLS/C0243073 denotes assay
T10036 14258-14265 UMLS/C0033684 denotes in) wer
T10035 14349-14365 UMLS/C2348236 denotes temperature in 2
T10034 14739-14743 UMLS/C1561571 denotes -70°
T10033 14739-14743 UMLS/C1561570 denotes -70°
T10032 14471-14475 UMLS/C0013618 denotes 5% g
T10031 14560-14569 UMLS/C0681850 denotes ed to ele
T10030 14088-14109 UMLS/C0032545 denotes nucleotide kinase (Ta
T10029 14379-14386 UMLS/C1167622 denotes g buffe
T10028 14739-14743 UMLS/C1561572 denotes -70°
T10027 14013-14021 UMLS/C1167624 denotes eling of
T10026 14225-14228 UMLS/C0041703 denotes . N
T10025 14088-14109 UP/P06855 denotes nucleotide kinase (Ta
T10024 13933-13938 UMLS/C1623218 denotes 17 pr
T10023 14516-14519 UMLS/C1456382 denotes d 5
T10022 14739-14743 UMLS/C1704608 denotes -70°
T10021 14448-14462 UMLS/C0012789 denotes threitol, 0.5
T10020 14379-14386 UMLS/C1145667 denotes g buffe
T10019 14560-14569 UMLS/C2697811 denotes ed to ele
T10018 14013-14021 UMLS/C1548779 denotes eling of
T10017 14781-14787 UMLS/C0034493 denotes lyclon
T10016 14379-14386 UMLS/C2349209 denotes g buffe
T10015 14516-14519 UP/P25695 denotes d 5
T10014 14834-14837 UMLS/C1705525 denotes nd
T10013 14682-14686 UMLS/C1551386 denotes e dr
T10012 13754-13757 UMLS/C1551386 denotes Gel
T10011 14739-14743 UMLS/C1705209 denotes -70°
T10010 13976-13979 UMLS/C1364818 denotes TT
T10009 13964-13967 UMLS/C1364818 denotes TA
T10008 14715-14725 UMLS/C0332157 denotes to Kodak X
T10007 14834-14837 UP/Q05894 denotes nd
T10006 13802-13818 UMLS/C0949374 denotes uclear proteins
T10005 14190-14197 UMLS/C1706132 denotes mns (St
T10004 14834-14837 UP/P23061 denotes nd
T10003 13976-13979 UMLS/C1705543 denotes TT
T10002 13964-13967 UMLS/C1705543 denotes TA
T10001 14013-14021 UMLS/C1947902 denotes eling of
T10000 14839-14842 UP/P41823 denotes Rel
T9999 14570-14572 UMLS/C0319022 denotes tr
T9998 14287-14299 UMLS/C0597354 denotes labeled DNA
T9997 14085-14087 UMLS/C0475751 denotes ol
T9996 13976-13979 UMLS/C0162871 denotes TT
T9995 13964-13967 UMLS/C0162871 denotes TA
T9994 13939-13947 UMLS/C0086860 denotes moter (5
T9993 14810-14817 UMLS/C0521124 denotes F-κB su
T9992 14171-14176 UMLS/C0182400 denotes e pur
T9991 13972-13975 UP/P82859 denotes AA
T9990 14171-14176 UMLS/C1704681 denotes e pur
T9361 13617-13624 UMLS/C1548982 denotes hybridi
T9360 13452-13459 UMLS/C1548982 denotes our tim
T9359 13577-13583 UMLS/C1442450 denotes room
T9358 12673-12679 UMLS/C1442450 denotes ur, wh
T9357 12687-12699 UMLS/C1881488 denotes lysates wer
T9356 13089-13096 UMLS/C1705493 denotes n hybri
T9355 12952-12959 UMLS/C2347026 denotes les wer
T9354 13709-13712 UMLS/C0812225 denotes ype
T9353 13709-13712 UMLS/C1704742 denotes ype
T9352 13183-13191 UMLS/C0041415 denotes 20 in Tr
T9351 12825-12828 UMLS/C1552937 denotes Pr
T9350 13637-13642 UMLS/C0175723 denotes e det
T9349 13527-13537 UMLS/C0003241 denotes s were add
T9348 13263-13273 UMLS/C0003241 denotes dies again
T9347 12729-12734 UMLS/C1136359 denotes s by
T9346 12952-12959 UMLS/C0870078 denotes les wer
T9345 12988-12992 UMLS/C0013862 denotes nd t
T9344 13605-13610 UMLS/C0231290 denotes -T wa
T9343 13446-13451 UMLS/C0231290 denotes hing
T9342 12652-12657 UMLS/C0231290 denotes r inc
T9341 13506-13516 UMLS/C0301869 denotes d secondar
T9340 13148-13160 UMLS/C0349375 denotes d milk in TB
T9339 13241-13248 UMLS/C1292425 denotes s, then
T9338 12997-13008 UMLS/C1547239 denotes erred to a
T9337 12729-12734 UMLS/C1948049 denotes s by
T9336 12830-12852 UMLS/C0427716 denotes ein concentrations in
T9335 13391-13394 UP/P02769 denotes T,
T9334 13699-13708 UMLS/C1511790 denotes kit and
T9333 13648-13656 UMLS/C1511790 denotes with the
T9332 12729-12734 UMLS/C0007634 denotes s by
T9331 13666-13674 UMLS/C1999177 denotes chemilum
T9330 13097-13110 UMLS/C0020202 denotes ization, memb
T9329 12825-12828 UMLS/C0439232 denotes Pr
T9328 12965-12974 UMLS/C1881713 denotes rated by
T9327 13543-13548 UMLS/C1524062 denotes allo
T9326 13407-13412 UMLS/C1524062 denotes d inc
T9325 12965-12974 UMLS/C0443299 denotes rated by
T9324 13391-13394 UMLS/C0005902 denotes T,
T9323 12825-12828 UMLS/C0702093 denotes Pr
T9322 13370-13377 UMLS/C1948037 denotes 1:1000
T9321 12830-12852 UMLS/C1304757 denotes ein concentrations in
T9320 12778-12789 UMLS/C0993864 denotes rifuged at
T9319 12952-12959 UMLS/C0370003 denotes les wer
T9318 13648-13656 UMLS/C0442726 denotes with the
T9317 12760-12765 UMLS/C0024348 denotes s buf
T9316 12997-13008 UMLS/C0348011 denotes erred to a
T9315 13605-13610 UMLS/C0687676 denotes -T wa
T9314 13446-13451 UMLS/C0687676 denotes hing
T9313 12652-12657 UMLS/C0687676 denotes r inc
T9312 13097-13110 UMLS/C0028602 denotes ization, memb
T9311 12997-13008 UMLS/C1555583 denotes erred to a
T9310 13666-13674 UMLS/C2349975 denotes chemilum
T9309 13255-13262 UMLS/C0205225 denotes y antib
T9308 13391-13394 UMLS/C0036774 denotes T,
T9307 12705-12713 UMLS/C1521827 denotes ared fro
T9306 12496-12517 UMLS/C0949466 denotes Western blot analysis
T9305 12633-12641 UMLS/C0251991 denotes 94002 (2
T9304 12610-12618 UMLS/C0392148 denotes sence or
T9303 13014-13028 UMLS/C0600190 denotes ellulose membr
T9302 13465-13470 UMLS/C1704250 denotes h TBS
T9301 13517-13526 UMLS/C0175668 denotes antibodi
T9300 13391-13394 UMLS/C0487992 denotes T,
T9299 12557-12561 UMLS/C1321301 denotes MC w
T9298 13170-13176 UMLS/C0006353 denotes (0.1%
T9297 12766-12772 UMLS/C0006353 denotes er, an
T9296 13391-13394 UMLS/C1511233 denotes T,
T9295 13334-13344 UMLS/C0039421 denotes gy Inc., B
T9294 13255-13262 UMLS/C0439631 denotes y antib
T9293 13506-13516 UMLS/C0522529 denotes d secondar
T9292 12997-13008 UMLS/C1540850 denotes erred to a
T9291 13241-13248 UMLS/C1547059 denotes s, then
T9290 13517-13526 UMLS/C1522484 denotes antibodi
T9289 12729-12734 UMLS/C1704653 denotes s by
T9288 12997-13008 UMLS/C0040671 denotes erred to a
T9287 12878-12888 UMLS/C0521095 denotes rmined wit
T9286 12907-12913 UMLS/C0449851 denotes od (Bi
T9285 13675-13692 UMLS/C0162524 denotes nescence (ECL) de
T9284 13527-13537 UMLS/C0021027 denotes s were add
T9283 13263-13273 UMLS/C0021027 denotes dies again
T9282 13637-13642 UMLS/C0439645 denotes e det
T9281 13209-13215 UMLS/C0036082 denotes ) at r
T9280 13076-13082 UMLS/C0038995 denotes ). For
T9279 12658-12668 UMLS/C1980044 denotes bation for
T9278 13465-13470 UMLS/C1548318 denotes h TBS
T9277 13517-13526 UMLS/C0027627 denotes antibodi
T9276 12622-12629 UMLS/C0424530 denotes ence of
T9275 13364-13367 UMLS/C0041703 denotes lut
T9274 12938-12941 UMLS/C0041703 denotes . P
T9273 13564-13572 UMLS/C1439852 denotes for 1 ho
T9272 13417-13426 UMLS/C1439852 denotes d overnig
T9271 12567-12576 UMLS/C1439852 denotes cubated w
T9270 13543-13548 UMLS/C1720086 denotes allo
T9269 13407-13412 UMLS/C1720086 denotes d inc
T9268 12729-12734 UMLS/C1269647 denotes s by
T9267 12681-12686 UMLS/C0444667 denotes e cel
T9266 13675-13692 UMLS/C1450278 denotes nescence (ECL) de
T9265 13694-13697 UMLS/C1332684 denotes cti
T9264 13465-13470 UMLS/C1547403 denotes h TBS
T9263 13553-13560 UMLS/C0683607 denotes o incub
T9262 13465-13470 UMLS/C1632851 denotes h TBS
T9261 12610-12618 UMLS/C0150312 denotes sence or
T9260 13561-13563 UMLS/C0319022 denotes te
T9259 13009-13011 UMLS/C0319022 denotes it
T9258 13370-13377 UMLS/C1720119 denotes 1:1000
T9257 13427-13436 UMLS/C0439583 denotes t at 4°C.
T9256 13731-13739 UMLS/C0034760 denotes (Amersha
T9255 13465-13470 UMLS/C0392761 denotes h TBS
T9254 13527-13537 UMLS/C1621287 denotes s were add
T9253 13263-13273 UMLS/C1621287 denotes dies again
T9252 12658-12668 UMLS/C1979572 denotes bation for
T9251 13302-13305 UP/Q8INB9 denotes d I
T9250 13282-13285 UP/Q8INB9 denotes hos
T9249 12541-12544 UP/Q8INB9 denotes Akt
T9248 12521-12524 UP/Q8INB9 denotes Akt
T9247 13274-13281 UMLS/C0521124 denotes t Akt,
T9246 13543-13548 UMLS/C1883712 denotes allo
T9245 13407-13412 UMLS/C1883712 denotes d inc
T9244 12952-12959 UMLS/C0441621 denotes les wer
T9243 13694-13697 UP/P83410 denotes cti
T9242 12907-12913 UMLS/C0025664 denotes od (Bi
T9241 12907-12913 UMLS/C0025663 denotes od (Bi
T9240 13465-13470 UMLS/C0449243 denotes h TBS
T9239 13465-13470 UMLS/C0040223 denotes h TBS
T9238 13694-13697 UP/P55797 denotes cti
T9237 13709-13712 UMLS/C1705212 denotes ype
T9236 13637-13642 UMLS/C0185014 denotes e det
T9235 12997-13008 UMLS/C0728827 denotes erred to a
T9234 12622-12629 UMLS/C0332197 denotes ence of
T9233 12860-12872 UMLS/C1550101 denotes rnatants wer
T9232 13709-13712 UMLS/C1690540 denotes ype
T9231 13460-13464 UMLS/C0205450 denotes s wi
T9230 13319-13333 UMLS/C0037083 denotes naling Technol
T9229 12622-12629 UMLS/C1689985 denotes ence of
T9228 13483-13505 UMLS/C0019941 denotes sh peroxidase-conjugat
T9227 12944-12951 UMLS/C0033684 denotes ein sam
T9226 12997-13008 UMLS/C1705822 denotes erred to a
T9225 13709-13712 UMLS/C1553450 denotes ype
T9224 13587-13603 UMLS/C2348236 denotes erature. After T
T9223 13220-13236 UMLS/C2348236 denotes emperature for 2
T9222 13517-13526 UMLS/C0205436 denotes antibodi
T9221 12965-12974 UMLS/C0086972 denotes rated by
T9220 12997-13008 UMLS/C1299988 denotes erred to a
T9219 12760-12765 UMLS/C1536403 denotes s buf
T8582 12016-12025 UMLS/C0443286 denotes s were pr
T8581 11580-11588 UMLS/C0443286 denotes n was pe
T8580 11876-11916 UP/P39460 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8579 11368-11389 UMLS/C0035380 denotes e transcription syste
T8578 11275-11296 UMLS/C0035380 denotes verse transcription o
T8577 11034-11048 UMLS/C0086045 denotes ncentrations o
T8576 11876-11916 UP/Q5JHB5 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8575 11848-11851 UMLS/C1413076 denotes GTG
T8574 11672-11677 UMLS/C0439175 denotes olume
T8573 11309-11314 UMLS/C0439175 denotes al mR
T8572 12459-12464 UMLS/C1547037 denotes -17 P
T8571 11001-11005 UMLS/C1321301 denotes MC w
T8570 11413-11418 UMLS/C0022341 denotes . PCR
T8569 11876-11916 UP/A1RV79 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8568 11876-11916 UP/C3NEV8 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8567 11730-11737 UMLS/C1279901 denotes for eac
T8566 11567-11574 UMLS/C1279901 denotes . The r
T8565 11876-11916 UP/Q92243 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8564 11876-11916 UP/P46713 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8563 11876-11916 UP/Q9Y8E9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8562 11788-11791 UMLS/C1424942 denotes GGG
T8561 11876-11916 UP/O32755 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8560 11876-11916 UP/Q01651 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8559 11876-11916 UP/A4WIW2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8558 11876-11916 UP/A3FKF7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8557 11390-11396 UMLS/C1553451 denotes (Taka
T8556 11876-11916 UP/C4KHW5 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8555 11876-11916 UP/P47543 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8554 11876-11916 UP/Q9UR38 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8553 11876-11916 UP/Q9Y796 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8552 11788-11791 UP/Q64559 denotes GGG
T8551 11876-11916 UP/C3NGT6 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8550 11011-11020 UMLS/C1439852 denotes cubated w
T8549 11876-11916 UP/O59494 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8548 11390-11396 UMLS/C0449913 denotes (Taka
T8547 11503-11521 UMLS/C0075813 denotes A polymerase (Taka
T8546 12378-12391 UMLS/C1521871 denotes on for each m
T8545 11425-11438 UMLS/C1521871 denotes ication of cD
T8544 11129-11134 UMLS/C0564385 denotes urs o
T8543 11876-11916 UP/P51469 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8542 11876-11916 UP/O59841 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8541 11876-11916 UP/P54226 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8540 11876-11916 UP/Q92211 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8539 11876-11916 UP/Q9YFS9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8538 11876-11916 UP/P10618 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8537 11876-11916 UP/P20445 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8536 11876-11916 UP/P20287 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8535 11191-11203 UMLS/C2598148 denotes boratories,
T8534 11788-11791 UMLS/C1865144 denotes GGG
T8533 11390-11396 UMLS/C1704459 denotes (Taka
T8532 11876-11916 UP/P44304 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8531 11876-11916 UP/C6A312 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8530 11876-11916 UP/A6VIW4 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8529 12478-12485 UMLS/C1704444 denotes r GAPDH
T8528 11138-11148 UMLS/C1979572 denotes cubation,
T8527 11876-11916 UP/Q9HGY7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8526 11876-11916 UP/P0CE13 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8525 11159-11168 UMLS/C1555707 denotes tracted w
T8524 11503-11521 UMLS/C2257065 denotes A polymerase (Taka
T8523 11659-11661 UMLS/C0020283 denotes i
T8522 12369-12374 UMLS/C0585064 denotes plifi
T8521 12401-12409 UMLS/C0567416 denotes he level
T8520 11747-11756 UMLS/C0567416 denotes s were us
T8519 11034-11048 UMLS/C1446561 denotes ncentrations o
T8518 12031-12040 UMLS/C1709694 denotes d in a DN
T8517 11876-11916 UP/P26988 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8516 11876-11916 UP/A9A6M9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8515 11876-11916 UP/Q01597 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8514 11876-11916 UP/P51009 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8513 11191-11203 UMLS/C1548427 denotes boratories,
T8512 11876-11916 UP/Q9Z518 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8511 11876-11916 UP/Q4KYY3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8510 11876-11916 UP/Q07234 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8509 11876-11916 UP/P08439 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8508 12478-12485 UMLS/C1550506 denotes r GAPDH
T8507 11876-11916 UP/A3CYG8 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8506 11876-11916 UP/Q92263 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8505 11947-11950 UMLS/C1333664 denotes GTA
T8504 11876-11916 UP/Q00584 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8503 11876-11916 UP/B0R2M2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8502 11788-11791 UMLS/C1412050 denotes GGG
T8501 11876-11916 UP/P15115 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8500 11876-11916 UP/Q8NK47 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8499 11876-11916 UP/B1YD06 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8498 11876-11916 UP/P19314 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8497 11788-11791 UMLS/C1825831 denotes GGG
T8496 11876-11916 UP/Q8TFJ2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8495 12459-12464 UMLS/C1610540 denotes -17 P
T8494 11091-11101 UMLS/C1999216 denotes hibitors (
T8493 11876-11916 UP/P0A1P1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8492 11876-11916 UP/P0C0G6 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8491 11939-11942 UMLS/C1420714 denotes GCG
T8490 12217-12220 UMLS/C0702093 denotes nga
T8489 12156-12159 UMLS/C0702093 denotes nea
T8488 11261-11273 UMLS/C0220931 denotes structions.
T8487 11659-11661 UMLS/C0031526 denotes i
T8486 11876-11916 UP/P0A1P0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8485 11876-11916 UP/P46796 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8484 11804-11807 UMLS/C0282160 denotes TTG
T8483 11876-11916 UP/P04406 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8482 11876-11916 UP/P35143 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8481 11876-11916 UP/P34783 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8480 11876-11916 UP/P24748 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8479 12424-12439 UMLS/C1515670 denotes sion was presen
T8478 11876-11916 UP/A6URW1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8477 11876-11916 UP/P27726 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8476 11876-11916 UP/P24751 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8475 12468-12473 UMLS/C0384648 denotes roduc
T8474 12308-12313 UMLS/C0384648 denotes was
T8473 12196-12201 UMLS/C0384648 denotes lowed
T8472 11820-11825 UMLS/C0384648 denotes tisen
T8471 11768-11773 UMLS/C0384648 denotes nse,
T8470 10920-10925 UMLS/C0384648 denotes IL-17
T8469 11876-11916 UP/P48812 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8468 11876-11916 UP/P32638 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8467 11876-11916 UP/B6YUU0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8466 11191-11203 UMLS/C0022877 denotes boratories,
T8465 11864-11867 UMLS/C2257889 denotes 3';
T8464 11876-11916 UP/P52694 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8463 11876-11916 UP/A5ULT9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8462 11593-11602 UMLS/C1550369 denotes ed in PCR
T8461 11460-11469 UMLS/C1550369 denotes med by ad
T8460 11324-11333 UMLS/C1550369 denotes formed at
T8459 12324-12334 UMLS/C0521095 denotes as falling
T8458 11876-11916 UP/Q3IUT3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8457 11876-11916 UP/Q48335 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8456 11876-11916 UP/A6UUN9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8455 11876-11916 UP/P0C0G7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8454 11876-11916 UP/Q6BMK0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8453 11876-11916 UP/P00355 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8452 12486-12490 UMLS/C0205136 denotes prod
T8451 11080-11087 UMLS/C0332197 denotes sence o
T8450 11876-11916 UP/Q59309 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8449 11876-11916 UP/P00361 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8448 11876-11916 UP/P23722 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8447 11876-11916 UP/Q27652 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8446 11876-11916 UP/Q89AK1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8445 11876-11916 UP/Q12XM4 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8444 11876-11916 UP/O42259 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8443 11876-11916 UP/Q6CCU7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8442 12005-12008 UMLS/C2699751 denotes '.
T8441 11951-11954 UMLS/C2699751 denotes C-3
T8440 11876-11916 UP/Q8PTD3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8439 11080-11087 UMLS/C0424530 denotes sence o
T8438 11876-11916 UP/Q5V061 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8437 11800-11803 UMLS/C0796552 denotes TCA
T8436 11876-11916 UP/Q59800 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8435 11876-11916 UP/Q9UVC0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8434 12468-12473 UMLS/C1623218 denotes roduc
T8433 12308-12313 UMLS/C1623218 denotes was
T8432 12196-12201 UMLS/C1623218 denotes lowed
T8431 11820-11825 UMLS/C1623218 denotes tisen
T8430 11768-11773 UMLS/C1623218 denotes nse,
T8429 10920-10925 UMLS/C1623218 denotes IL-17
T8428 11925-11930 UMLS/C0036658 denotes '-CGA
T8427 11774-11779 UMLS/C0036658 denotes '-ATG
T8426 11710-11715 UMLS/C0036658 denotes d ant
T8425 11547-11552 UMLS/C0036658 denotes nd an
T8424 11876-11916 UP/O28542 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8423 11876-11916 UP/Q9PJN6 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8422 11876-11916 UP/P24750 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8421 12031-12040 UMLS/C1522240 denotes d in a DN
T8420 11876-11916 UP/Q6L125 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8419 11876-11916 UP/Q6M0E6 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8418 11876-11916 UP/Q9HSS7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8417 11876-11916 UP/O52631 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8416 12357-12368 UMLS/C1552645 denotes phase of a
T8415 11876-11916 UP/Q59199 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8414 12338-12345 UMLS/C1272705 denotes hin the
T8413 11447-11455 UMLS/C1510844 denotes ts was p
T8412 11876-11916 UP/P09316 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8411 11876-11916 UP/Q59906 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8410 11876-11916 UP/B0B879 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8409 11730-11737 UMLS/C0206415 denotes for eac
T8408 11567-11574 UMLS/C0206415 denotes . The r
T8407 11876-11916 UP/Q9P8C0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8406 11876-11916 UP/Q4U3L0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8405 11876-11916 UP/P58839 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8404 11876-11916 UP/Q5R2J2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8403 11876-11916 UP/Q12552 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8402 11876-11916 UP/Q28554 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8401 12031-12040 UMLS/C1551390 denotes d in a DN
T8400 11876-11916 UP/P52987 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8399 12468-12473 UMLS/C1825592 denotes roduc
T8398 12308-12313 UMLS/C1825592 denotes was
T8397 12196-12201 UMLS/C1825592 denotes lowed
T8396 11820-11825 UMLS/C1825592 denotes tisen
T8395 11768-11773 UMLS/C1825592 denotes nse,
T8394 10920-10925 UMLS/C1825592 denotes IL-17
T8393 11876-11916 UP/P64179 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8392 11876-11916 UP/P61879 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8391 11788-11791 UMLS/C1550741 denotes GGG
T8390 11876-11916 UP/P17244 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8389 11672-11677 UMLS/C0439810 denotes olume
T8388 11442-11446 UMLS/C0006556 denotes liqu
T8387 11788-11791 UMLS/C0279208 denotes GGG
T8386 12277-12283 UMLS/C1511572 denotes for b
T8385 12112-12118 UMLS/C1511572 denotes or 30
T8384 11309-11314 UMLS/C0439810 denotes al mR
T8383 12050-12064 UMLS/C1611676 denotes cycler (Perkin
T8382 11804-11807 UMLS/C0175754 denotes TTG
T8381 11848-11851 UMLS/C0279290 denotes GTG
T8380 12203-12211 UMLS/C0332283 denotes y 1 min
T8379 11700-11709 UMLS/C0332283 denotes g sense a
T8378 11993-11996 UMLS/C1419183 denotes GGA
T8377 12203-12211 UMLS/C0332282 denotes y 1 min
T8376 11700-11709 UMLS/C0332282 denotes g sense a
T8375 11678-11684 UMLS/C0449468 denotes of 25
T8374 11876-11916 UP/C3MWN0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8373 12261-12269 UMLS/C1705914 denotes r 25 cyc
T8372 12444-12453 UMLS/C0449450 denotes s a ratio
T8371 11876-11916 UP/P00362 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8370 11246-11260 UMLS/C0947322 denotes nufacturer's i
T8369 11876-11916 UP/Q8K8M9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8368 11876-11916 UP/Q9ZKT0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8367 11876-11916 UP/P29497 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8300 11808-11811 UMLS/C0041405 denotes 3';
T8299 11876-11916 UP/Q9Z7T0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8298 11876-11916 UP/Q757I2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8297 11876-11916 UP/A4FZL2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8296 11876-11916 UP/Q9N2D5 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8295 12031-12040 UMLS/C1550044 denotes d in a DN
T8294 11876-11916 UP/A2BLC6 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8293 11473-11479 UMLS/C1524062 denotes 2.5 m
T8292 11876-11916 UP/P53430 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8291 11876-11916 UP/Q9V1P1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8290 11261-11273 UMLS/C1292796 denotes structions.
T8289 11876-11916 UP/Q4J940 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8288 11876-11916 UP/P10096 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8287 11876-11916 UP/O57479 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8286 11659-11661 UMLS/C2363150 denotes i
T8285 11120-11125 UMLS/C0687676 denotes ter 1
T8284 11659-11661 UMLS/C0450409 denotes i
T8283 11659-11661 UMLS/C0450408 denotes i
T8282 11659-11661 UMLS/C0450407 denotes i
T8281 11593-11602 UMLS/C0884358 denotes ed in PCR
T8280 11460-11469 UMLS/C0884358 denotes med by ad
T8279 11324-11333 UMLS/C0884358 denotes formed at
T8278 11678-11684 UMLS/C1705102 denotes of 25
T8277 11103-11111 UMLS/C0251991 denotes 294002,
T8276 12468-12473 UMLS/C1522571 denotes roduc
T8275 12308-12313 UMLS/C1522571 denotes was
T8274 12196-12201 UMLS/C1522571 denotes lowed
T8273 11820-11825 UMLS/C1522571 denotes tisen
T8272 11768-11773 UMLS/C1522571 denotes nse,
T8271 10920-10925 UMLS/C1522571 denotes IL-17
T8270 11068-11076 UMLS/C0392148 denotes esence o
T8269 12338-12345 UMLS/C0085639 denotes hin the
T8268 11113-11117 UMLS/C0084183 denotes TC).
T8267 11191-11203 UMLS/C1619828 denotes boratories,
T8266 11876-11916 UP/Q05025 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8265 12474-12477 UMLS/C0032520 denotes ov
T8264 12245-12248 UMLS/C0032520 denotes wer
T8263 11606-11609 UMLS/C0032520 denotes fer
T8262 11421-11424 UMLS/C0032520 denotes pli
T8261 10975-11000 UMLS/C0032520 denotes lymerase chain reaction P
T8260 11091-11101 UMLS/C0243077 denotes hibitors (
T8259 11876-11916 UP/C3MQN0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8258 11876-11916 UP/A3MTU1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8257 11788-11791 UMLS/C0427611 denotes GGG
T8256 11876-11916 UP/P94915 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8255 11876-11916 UP/P55070 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8254 11876-11916 UP/Q2NEN0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8253 11876-11916 UP/O83816 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8252 11876-11916 UP/P55971 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8622 11876-11916 UP/P24753 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8621 11993-11996 UMLS/C0205851 denotes GGA
T8620 11788-11791 UP/P15318 denotes GGG
T8619 12315-12319 UMLS/C0323983 denotes term
T8618 12131-12143 UMLS/C0301642 denotes tion at 94°C
T8617 11876-11916 UP/P87197 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8616 11800-11803 UMLS/C1417239 denotes TCA
T8615 12016-12025 UMLS/C1114821 denotes s were pr
T8614 11580-11588 UMLS/C1114821 denotes n was pe
T8613 11191-11203 UMLS/C1697786 denotes boratories,
T8612 11792-11795 UMLS/C1413193 denotes AAG
T8611 11261-11273 UMLS/C1442085 denotes structions.
T8610 11876-11916 UP/O67161 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8609 12031-12040 UMLS/C1184743 denotes d in a DN
T8608 11246-11260 UMLS/C1546933 denotes nufacturer's i
T8607 11876-11916 UP/P00356 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8606 11876-11916 UP/P24749 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8605 11625-11630 UMLS/C0024472 denotes 50 mM
T8604 11876-11916 UP/Q58546 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8603 11876-11916 UP/Q01982 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8602 11129-11134 UMLS/C0439227 denotes urs o
T8601 11120-11125 UMLS/C0231290 denotes ter 1
T8600 11852-11855 UMLS/C0003354 denotes GAC
T8599 11876-11916 UP/Q94469 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8598 11876-11916 UP/P57384 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8597 11876-11916 UP/A7IB57 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8596 12459-12464 UMLS/C0456603 denotes -17 P
T8595 11876-11916 UP/P17721 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8594 11876-11916 UP/P04797 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8593 12217-12220 UMLS/C0439232 denotes nga
T8592 12156-12159 UMLS/C0439232 denotes nea
T8591 11876-11916 UP/P19089 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8590 11864-11867 UMLS/C1418544 denotes 3';
T8589 11876-11916 UP/P75358 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8588 12046-12049 UMLS/C0012854 denotes mal
T8587 11876-11916 UP/Q9N655 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8586 11246-11260 UMLS/C1705426 denotes nufacturer's i
T8585 11955-11958 UMLS/C2697657 denotes ; G
T8584 11788-11791 UP/Q57506 denotes GGG
T8583 11852-11855 UMLS/C0003442 denotes GAC
T8251 11876-11916 UP/Q1DTF9 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8250 11876-11916 UP/Q00301 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8249 12099-12102 UMLS/C0041703 denotes oug
T8248 11218-11221 UMLS/C0041703 denotes A)
T8247 11876-11916 UP/P24164 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8246 11876-11916 UP/P54117 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8245 11473-11479 UMLS/C1720086 denotes 2.5 m
T8244 11876-11916 UP/C3N6F0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8243 11876-11916 UP/Q8ZWK7 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8242 11876-11916 UP/Q5XDW3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8241 11876-11916 UP/P16858 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8240 11876-11916 UP/P32637 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8239 11678-11684 UMLS/C2700258 denotes of 25
T8238 11876-11916 UP/P70685 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8237 11876-11916 UP/P55071 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8236 12298-12303 UMLS/C1414968 denotes L-17;
T8235 12186-12191 UMLS/C1414968 denotes IL-17
T8234 11965-11970 UMLS/C1414968 denotes tisen
T8233 11918-11923 UMLS/C1414968 denotes ense,
T8232 11876-11916 UMLS/C1414968 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8231 11876-11916 UP/P24166 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8230 11876-11916 UP/Q8X1X3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8229 11315-11319 UMLS/C0035696 denotes A wa
T8228 11150-11154 UMLS/C0035696 denotes NA w
T8227 10926-10930 UMLS/C0035696 denotes mRNA
T8226 11876-11916 UP/Q2FNA2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8225 11876-11916 UP/Q00640 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8224 11876-11916 UP/P28844 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8223 11876-11916 UP/O57672 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8222 11876-11916 UP/P64178 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8221 12478-12485 UMLS/C1514468 denotes r GAPDH
T8220 11876-11916 UP/P61880 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8219 11876-11916 UP/Q971K2 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8366 11610-11616 UMLS/C0006353 denotes (1.5 m
T8365 11876-11916 UP/Q9UW96 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8364 11876-11916 UP/A4YHA5 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8363 11159-11168 UMLS/C1705851 denotes tracted w
T8362 11848-11851 UMLS/C0280453 denotes GTG
T8361 11993-11996 UMLS/C0220620 denotes GGA
T8360 11989-11992 UMLS/C1415587 denotes CAG
T8359 11808-11811 UMLS/C1415587 denotes 3';
T8358 11246-11260 UMLS/C1548599 denotes nufacturer's i
T8357 11138-11148 UMLS/C1980044 denotes cubation,
T8356 12378-12391 UMLS/C1517480 denotes on for each m
T8355 11425-11438 UMLS/C1517480 denotes ication of cD
T8354 11080-11087 UMLS/C1689985 denotes sence o
T8353 11947-11950 UMLS/C0017687 denotes GTA
T8352 11876-11916 UP/Q5XJ10 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8351 11730-11737 UMLS/C0205435 denotes for eac
T8350 11567-11574 UMLS/C0205435 denotes . The r
T8349 12203-12211 UMLS/C1719822 denotes y 1 min
T8348 11700-11709 UMLS/C1719822 denotes g sense a
T8347 11947-11950 UMLS/C1705879 denotes GTA
T8346 11678-11684 UMLS/C1690016 denotes of 25
T8345 11876-11916 UP/P46406 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8344 11876-11916 UP/Q9HJ69 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8343 11876-11916 UP/P51640 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8342 11876-11916 UP/P83601 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8341 11864-11867 UMLS/C0052586 denotes 3';
T8340 12046-12049 UMLS/C1325786 denotes mal
T8339 11261-11273 UMLS/C0302828 denotes structions.
T8338 12444-12453 UMLS/C0150312 denotes s a ratio
T8337 11068-11076 UMLS/C0150312 denotes esence o
T8336 11876-11916 UMLS/C0017857 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8335 12378-12391 UMLS/C1705759 denotes on for each m
T8334 11425-11438 UMLS/C1705759 denotes ication of cD
T8333 12249-12255 UMLS/C0332490 denotes repea
T8332 12369-12374 UMLS/C0205390 denotes plifi
T8331 11473-11479 UMLS/C1883712 denotes 2.5 m
T8330 11876-11916 UP/Q9HFX1 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8329 12261-12269 UMLS/C0205341 denotes r 25 cyc
T8328 11876-11916 UP/Q28259 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8327 12415-12420 UMLS/C0456079 denotes NA ex
T8326 11876-11916 UP/P24163 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8325 11876-11916 UP/P19315 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8324 11876-11916 UP/P56649 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8323 11876-11916 UP/Q96US8 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8322 11876-11916 UP/Q97BJ8 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8321 11792-11795 UMLS/C1426689 denotes AAG
T8320 11261-11273 UMLS/C0039401 denotes structions.
T8319 11191-11203 UMLS/C1571737 denotes boratories,
T8318 12415-12420 UMLS/C0441889 denotes NA ex
T8317 11659-11661 UMLS/C1304686 denotes i
T8316 11876-11916 UP/P68777 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8315 12261-12269 UMLS/C1547730 denotes r 25 cyc
T8314 11876-11916 UP/Q5RAB4 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8313 11876-11916 UP/O27090 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8312 12217-12220 UMLS/C1552937 denotes nga
T8311 12156-12159 UMLS/C1552937 denotes nea
T8310 11876-11916 UP/P00357 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8309 11876-11916 UP/Q8J1H3 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8308 11876-11916 UP/P46795 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8307 12338-12345 UMLS/C0231174 denotes hin the
T8306 11876-11916 UP/Q8WZN0 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8305 11876-11916 UP/O13507 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8304 11876-11916 UP/P09317 denotes dehyde-3-phosphate dehydrogenase (GAPDH)
T8303 11159-11168 UMLS/C0185115 denotes tracted w
T8302 10951-10958 UMLS/C1555029 denotes reverse
T8301 11989-11992 UMLS/C0041405 denotes CAG
T7491 10324-10330 UMLS/C1548982 denotes ain an
T7490 10206-10213 UMLS/C1548982 denotes ng, str
T7489 10003-10009 UMLS/C1548982 denotes d four
T7488 10887-10892 UMLS/C1825592 denotes test
T7487 10640-10645 UMLS/C1825592 denotes uted
T7486 10592-10597 UMLS/C1825592 denotes ectio
T7485 10145-10150 UMLS/C1825592 denotes (R &
T7484 9890-9895 UMLS/C1825592 denotes (R &
T7483 9670-9675 UMLS/C1825592 denotes L-17
T7482 9463-9468 UMLS/C1825592 denotes IL-17
T7481 9457-9462 UMLS/C1825592 denotes IL-17
T7480 10741-10749 UMLS/C0175675 denotes curve wa
T7479 10698-10706 UMLS/C0175675 denotes ranging
T7478 9869-9877 UMLS/C0175675 denotes ard reco
T7477 10467-10475 UMLS/C1114821 denotes was stop
T7476 10453-10461 UMLS/C1114821 denotes The rea
T7475 10425-10430 UMLS/C1719918 denotes deve
T7474 10389-10394 UMLS/C1719918 denotes ssolv
T7473 10285-10290 UMLS/C1719918 denotes s inc
T7472 9497-9505 UMLS/C1879489 denotes measured
T7471 9853-9860 UMLS/C2347026 denotes es and
T7470 10577-10582 UMLS/C1299352 denotes it of
T7469 10052-10060 UMLS/C0041415 denotes 20, and
T7468 9793-9801 UMLS/C0041415 denotes een 20 f
T7467 10569-10571 UMLS/C0439282 denotes ow
T7466 9472-9479 UMLS/C0220814 denotes culture
T7465 10090-10095 UMLS/C0439275 denotes biot
T7464 10870-10883 UMLS/C0680730 denotes tion of IL-17
T7463 10741-10749 UMLS/C1548173 denotes curve wa
T7462 10698-10706 UMLS/C1548173 denotes ranging
T7461 9869-9877 UMLS/C1548173 denotes ard reco
T7460 9853-9860 UMLS/C0870078 denotes es and
T7459 9640-9661 UMLS/C0003250 denotes onoclonal antibodies
T7458 10200-10205 UMLS/C0231290 denotes wash
T7457 9711-9716 UMLS/C0231290 denotes ter b
T7456 10274-10283 UMLS/C0301869 denotes (Sigma)
T7455 10577-10582 UMLS/C1550472 denotes it of
T7454 10760-10765 UMLS/C0013113 denotes plott
T7453 10310-10317 UMLS/C1292425 denotes then wa
T7452 10171-10178 UMLS/C1292425 denotes rs at r
T7451 9982-9989 UMLS/C1292425 denotes rs. Pla
T7450 9806-9813 UMLS/C1292425 denotes hours a
T7449 10583-10588 UMLS/C0439801 denotes IL-17
T7448 10657-10671 UMLS/C0010454 denotes edium was used
T7447 10622-10633 UMLS/C1514798 denotes nt human IL
T7446 9878-9889 UMLS/C1514798 denotes binant IL-1
T7445 9472-9479 UMLS/C0010453 denotes culture
T7444 9782-9785 UP/P02769 denotes A)/
T7443 10598-10607 UMLS/C1511790 denotes was 10 p
T7442 9619-9625 UMLS/C0453946 denotes coated
T7441 10447-10452 UMLS/C1880121 denotes ction
T7440 9555-9564 UMLS/C1552738 denotes described
T7439 9917-9922 UMLS/C1524062 denotes to t
T7438 9497-9505 UMLS/C0242485 denotes measured
T7437 9782-9785 UMLS/C0005902 denotes A)/
T7436 9585-9590 UMLS/C1879313 denotes brief
T7435 10425-10430 UMLS/C0227391 denotes deve
T7434 10389-10394 UMLS/C0227391 denotes ssolv
T7433 10285-10290 UMLS/C0227391 denotes s inc
T7432 10583-10588 UMLS/C1549479 denotes IL-17
T7431 9640-9661 UMLS/C0520150 denotes onoclonal antibodies
T7430 10646-10653 UMLS/C1948037 denotes n cultu
T7429 10577-10582 UMLS/C1611820 denotes it of
T7428 9853-9860 UMLS/C0370003 denotes es and
T7427 10577-10582 UMLS/C0205251 denotes it of
T7426 10577-10582 UMLS/C0234886 denotes it of
T7425 10741-10749 UMLS/C0038137 denotes curve wa
T7424 10698-10706 UMLS/C0038137 denotes ranging
T7423 9869-9877 UMLS/C0038137 denotes ard reco
T7422 9619-9625 UMLS/C1704806 denotes coated
T7421 10447-10452 UMLS/C0009399 denotes ction
T7378 10870-10883 UMLS/C1148554 denotes tion of IL-17
T7377 10887-10892 UMLS/C0384648 denotes test
T7376 10640-10645 UMLS/C0384648 denotes uted
T7375 10592-10597 UMLS/C0384648 denotes ectio
T7374 10145-10150 UMLS/C0384648 denotes (R &
T7373 9890-9895 UMLS/C0384648 denotes (R &
T7372 9670-9675 UMLS/C0384648 denotes L-17
T7371 9463-9468 UMLS/C0384648 denotes IL-17
T7370 9457-9462 UMLS/C0384648 denotes IL-17
T7369 10447-10452 UMLS/C1552079 denotes ction
T7368 10274-10283 UMLS/C0522529 denotes (Sigma)
T7367 10310-10317 UMLS/C1547059 denotes then wa
T7366 10171-10178 UMLS/C1547059 denotes rs at r
T7365 9982-9989 UMLS/C1547059 denotes rs. Pla
T7364 9806-9813 UMLS/C1547059 denotes hours a
T7363 10548-10556 UMLS/C0031206 denotes read at
T7362 10806-10809 UMLS/C1708728 denotes e c
T7361 9717-9725 UMLS/C0332206 denotes ocking w
T7360 10896-10900 UMLS/C0022885 denotes les.
T7359 9848-9852 UMLS/C0022885 denotes samp
T7358 10750-10755 UMLS/C0205134 denotes draw
T7357 9717-9725 UMLS/C1706084 denotes ocking w
T7356 10045-10051 UMLS/C0036082 denotes e/Twee
T7355 9750-9756 UMLS/C0036082 denotes line/1
T7354 10015-10020 UMLS/C1548318 denotes with
T7353 9480-9492 UMLS/C1550101 denotes supernatants
T7352 10010-10014 UMLS/C0205450 denotes time
T7351 10364-10387 UMLS/C0134796 denotes enyl phosphate (Sigma)
T7350 10896-10900 UMLS/C0013702 denotes les.
T7349 9848-9852 UMLS/C0013702 denotes samp
T7348 10251-10273 UMLS/C0019941 denotes sh peroxidase conjugat
T7347 10158-10165 UMLS/C1553451 denotes ms) for
T7346 9903-9910 UMLS/C1553451 denotes ms) wer
T7345 9683-9690 UMLS/C1553451 denotes ystems)
T7344 10577-10582 UMLS/C0441994 denotes it of
T7343 10182-10198 UMLS/C2348236 denotes temperature. Aft
T7342 9961-9977 UMLS/C2348236 denotes temperature for
T7341 9817-9833 UMLS/C2348236 denotes om temperature (
T7340 10447-10452 UMLS/C1550604 denotes ction
T7339 10447-10452 UMLS/C0009393 denotes ction
T7338 10686-10697 UMLS/C0006751 denotes on standard
T7337 10896-10900 UMLS/C0039593 denotes les.
T7336 9848-9852 UMLS/C0039593 denotes samp
T7335 10341-10350 UMLS/C1439852 denotes with 1 m
T7334 10296-10305 UMLS/C1439852 denotes for 2 ho
T7333 10071-10080 UMLS/C1439852 denotes ated with
T7332 9948-9957 UMLS/C1439852 denotes ated at r
T7331 9717-9725 UMLS/C1533157 denotes ocking w
T7330 10577-10582 UMLS/C1708760 denotes it of
T7329 10447-10452 UMLS/C0013343 denotes ction
T7328 10887-10892 UMLS/C1623218 denotes test
T7327 10640-10645 UMLS/C1623218 denotes uted
T7326 10592-10597 UMLS/C1623218 denotes ectio
T7325 10145-10150 UMLS/C1623218 denotes (R &
T7324 9890-9895 UMLS/C1623218 denotes (R &
T7323 9670-9675 UMLS/C1623218 denotes L-17
T7322 9463-9468 UMLS/C1623218 denotes IL-17
T7321 9457-9462 UMLS/C1623218 denotes IL-17
T7320 10396-10405 UMLS/C1549535 denotes in dieth
T7319 10158-10165 UMLS/C0449913 denotes ms) for
T7318 9903-9910 UMLS/C0449913 denotes ms) wer
T7317 9683-9690 UMLS/C0449913 denotes ystems)
T7316 10109-10136 UMLS/C0359168 denotes monoclonal antibodies agai
T7315 10480-10487 UMLS/C1947925 denotes y the a
T7314 9917-9922 UMLS/C1720086 denotes to t
T7313 10577-10582 UMLS/C1619811 denotes it of
T7312 10896-10900 UMLS/C0392366 denotes les.
T7311 9848-9852 UMLS/C0392366 denotes samp
T7310 10583-10588 UMLS/C0205189 denotes IL-17
T7309 9991-9997 UMLS/C0407295 denotes s were
T7308 9938-9943 UMLS/C0407295 denotes and
T7307 9602-9607 UMLS/C0407295 denotes plate
T7306 9497-9505 UMLS/C0079809 denotes measured
T7305 10577-10582 UMLS/C1548802 denotes it of
T7304 10583-10588 UMLS/C1549649 denotes IL-17
T7303 10015-10020 UMLS/C1547403 denotes with
T7302 10708-10715 UMLS/C2348147 denotes rom 10
T7301 10015-10020 UMLS/C1632851 denotes with
T7300 9619-9625 UMLS/C1522408 denotes coated
T7299 10447-10452 UMLS/C1704457 denotes ction
T7298 10724-10726 UMLS/C0319022 denotes g/
T7297 10432-10434 UMLS/C0319022 denotes p
T7296 9923-9925 UMLS/C0319022 denotes e
T7295 10646-10653 UMLS/C1720119 denotes n cultu
T7294 9991-9997 UMLS/C1139930 denotes s were
T7293 9938-9943 UMLS/C1139930 denotes and
T7292 9602-9607 UMLS/C1139930 denotes plate
T7291 9497-9505 UMLS/C0444706 denotes measured
T7290 9700-9709 UMLS/C0439583 denotes ernight.
T7289 10015-10020 UMLS/C0392761 denotes with
T7288 10158-10165 UMLS/C1704459 denotes ms) for
T7287 9903-9910 UMLS/C1704459 denotes ms) wer
T7286 9683-9690 UMLS/C1704459 denotes ystems)
T7285 9717-9725 UMLS/C0028778 denotes ocking w
T7284 9619-9625 UMLS/C0325028 denotes coated
T7283 10896-10900 UMLS/C0183885 denotes les.
T7282 9848-9852 UMLS/C0183885 denotes samp
T7281 10557-10561 UMLS/C0034754 denotes 05 n
T7280 10583-10588 UMLS/C0449295 denotes IL-17
T7279 10230-10238 UMLS/C1979842 denotes e phosph
T7278 10557-10561 UMLS/C1705179 denotes 05 n
T7277 10732-10737 UMLS/C0439297 denotes stand
T7276 10615-10620 UMLS/C0439297 denotes combi
T7275 9717-9725 UMLS/C0233660 denotes ocking w
T7274 10794-10801 UMLS/C0521124 denotes he log
T7273 10137-10144 UMLS/C0521124 denotes st IL-1
T7272 9662-9669 UMLS/C0521124 denotes gainst
T7271 10495-10503 UMLS/C1883712 denotes of 1 M N
T7270 9917-9922 UMLS/C1883712 denotes to t
T7269 10409-10423 UMLS/C0057919 denotes amine (Sigma)
T7268 10708-10715 UMLS/C1514721 denotes rom 10
T7267 9853-9860 UMLS/C0441621 denotes es and
T7266 9619-9625 UMLS/C0999543 denotes coated
T7265 10015-10020 UMLS/C0449243 denotes with
T7264 10583-10588 UMLS/C2349209 denotes IL-17
T7263 10015-10020 UMLS/C0040223 denotes with
T7262 10447-10452 UMLS/C1705245 denotes ction
T7261 10817-10830 UMLS/C1446561 denotes tion of recom
T6654 9104-9111 UMLS/C1705424 denotes with an
T6653 8703-8706 UMLS/C1426940 denotes tai
T6652 8481-8484 UMLS/C1426940 denotes BS
T6651 8909-8917 UMLS/C1264633 denotes on. Enri
T6650 9322-9329 UMLS/C0038128 denotes on a F
T6649 9040-9047 UMLS/C0038128 denotes d with
T6648 8707-8715 UMLS/C0038128 denotes ing buff
T6647 8485-8493 UMLS/C0038128 denotes taining
T6646 8988-8993 UMLS/C0687676 denotes remov
T6645 9310-9318 UMLS/C0936012 denotes tained c
T6644 8724-8732 UMLS/C1998480 denotes ted, res
T6643 9011-9017 UMLS/C0563532 denotes . Alte
T6642 8808-8814 UMLS/C0563532 denotes fitte
T6641 9341-9345 UMLS/C0598442 denotes sort
T6640 8703-8706 UMLS/C0268150 denotes tai
T6639 8481-8484 UMLS/C0268150 denotes BS
T6638 9390-9398 UMLS/C1546680 denotes s had th
T6637 8416-8428 UMLS/C0947322 denotes manufacturer
T6636 9179-9189 UMLS/C0038960 denotes ; 15 min,
T6635 8815-8821 UMLS/C0009951 denotes with
T6634 8334-8343 UMLS/C0220862 denotes isolation
T6633 8446-8450 UMLS/C1321301 denotes PBMC
T6632 8716-8722 UMLS/C0006353 denotes r, pel
T6631 8494-8500 UMLS/C0006353 denotes uffer.
T6630 8616-8626 UMLS/C0522529 denotes gated anti
T6629 8724-8732 UMLS/C0441436 denotes ted, res
T6628 9399-9404 UMLS/C1704653 denotes CD4
T6627 9330-9335 UMLS/C1704653 denotes CS Va
T6626 9272-9277 UMLS/C1704653 denotes essed
T6625 9174-9178 UMLS/C1704653 denotes nsio
T6624 9034-9039 UMLS/C1704653 denotes stain
T6623 8928-8933 UMLS/C1704653 denotes were
T6622 8671-8676 UMLS/C1704653 denotes were
T6621 8603-8615 UMLS/C0016342 denotes ochrome-conj
T6620 8581-8591 UMLS/C0522534 denotes ating amou
T6619 8627-8637 UMLS/C0021027 denotes odies were
T6618 8981-8987 UMLS/C1185738 denotes after
T6617 8837-8843 UMLS/C1185738 denotes . Flow
T6616 8416-8428 UMLS/C1548599 denotes manufacturer
T6615 9294-9298 UMLS/C0806140 denotes ic a
T6614 8845-8849 UMLS/C0806140 denotes hrou
T6613 8952-8955 UMLS/C0205448 denotes 5 m
T6612 8862-8865 UMLS/C0205448 denotes ml
T6611 9251-9256 UMLS/C1552828 denotes rity
T6610 8724-8732 UMLS/C0993610 denotes ted, res
T6609 9011-9017 UMLS/C1706318 denotes . Alte
T6608 8808-8814 UMLS/C1706318 denotes fitte
T6607 9390-9398 UMLS/C0370215 denotes s had th
T6606 8724-8732 UMLS/C1706128 denotes ted, res
T7420 10467-10475 UMLS/C0443286 denotes was stop
T7419 10453-10461 UMLS/C0443286 denotes The rea
T7418 10634-10639 UMLS/C0020156 denotes 17 di
T7417 10817-10830 UMLS/C0086045 denotes tion of recom
T7416 10200-10205 UMLS/C0687676 denotes wash
T7415 9711-9716 UMLS/C0687676 denotes ter b
T7414 10778-10793 UMLS/C1268822 denotes ensity against
T7413 10524-10539 UMLS/C1268822 denotes ensity of each
T7412 10569-10571 UMLS/C0439202 denotes ow
T7411 9585-9590 UMLS/C0453896 denotes brief
T7410 9472-9479 UMLS/C2242979 denotes culture
T7409 9619-9625 UMLS/C1697272 denotes coated
T7408 10447-10452 UMLS/C1547016 denotes ction
T7407 9991-9997 UMLS/C0005971 denotes s were
T7406 9938-9943 UMLS/C0005971 denotes and
T7405 9602-9607 UMLS/C0005971 denotes plate
T7404 9619-9625 UMLS/C1705944 denotes coated
T7403 10834-10855 UMLS/C1524094 denotes nt cytokines, and use
T7402 9518-9551 UMLS/C0014441 denotes enzyme-linked immunosorbent assay
T7401 9420-9453 UMLS/C0014441 denotes Enzyme-linked immunosorbent assay
T7400 9782-9785 UMLS/C0036774 denotes A)/
T7399 9760-9780 UMLS/C0036774 denotes vine serum albumin (
T7398 10887-10892 UMLS/C1522571 denotes test
T7397 10640-10645 UMLS/C1522571 denotes uted
T7396 10592-10597 UMLS/C1522571 denotes ectio
T7395 10145-10150 UMLS/C1522571 denotes (R &
T7394 9890-9895 UMLS/C1522571 denotes (R &
T7393 9670-9675 UMLS/C1522571 denotes L-17
T7392 9463-9468 UMLS/C1522571 denotes IL-17
T7391 9457-9462 UMLS/C1522571 denotes IL-17
T7390 10480-10487 UMLS/C1522314 denotes y the a
T7389 10741-10749 UMLS/C1442989 denotes curve wa
T7388 10698-10706 UMLS/C1442989 denotes ranging
T7387 9869-9877 UMLS/C1442989 denotes ard reco
T7386 9472-9479 UMLS/C0430400 denotes culture
T7385 10015-10020 UMLS/C1704250 denotes with
T7384 10778-10793 UMLS/C0439164 denotes ensity against
T7383 10524-10539 UMLS/C0439164 denotes ensity of each
T7382 9782-9785 UMLS/C0487992 denotes A)/
T7381 9619-9625 UMLS/C1552080 denotes coated
T7380 9782-9785 UMLS/C1511233 denotes A)/
T7379 10480-10487 UMLS/C0450446 denotes y the a
T6605 9251-9256 UMLS/C1282910 denotes rity
T6604 8900-8908 UMLS/C1513916 denotes ve fract
T6603 9228-9237 UMLS/C0086972 denotes described
T6602 8774-8783 UMLS/C0086972 denotes ted, usua
T6601 8592-8599 UMLS/C1561574 denotes ts of f
T6600 8900-8908 UMLS/C0205160 denotes ve fract
T6599 9104-9111 UMLS/C1167624 denotes with an
T6598 9310-9318 UMLS/C1524024 denotes tained c
T6597 8334-8343 UMLS/C1608300 denotes isolation
T6596 8546-8555 UMLS/C1439852 denotes cubated f
T6595 9322-9329 UMLS/C0487602 denotes on a F
T6594 9040-9047 UMLS/C0487602 denotes d with
T6593 8707-8715 UMLS/C0487602 denotes ing buff
T6592 8485-8493 UMLS/C0487602 denotes taining
T6591 9136-9146 UMLS/C0026032 denotes ds (20 μl
T6590 8511-8521 UMLS/C0026032 denotes icrobeads
T6589 8361-8371 UMLS/C0026032 denotes microbeads
T6588 9368-9372 UMLS/C0205172 denotes ) of
T6587 8334-8343 UMLS/C1608299 denotes isolation
T6586 8334-8343 UMLS/C1548355 denotes isolation
T6585 9155-9160 UMLS/C1720086 denotes 80 μl
T6584 8643-8648 UMLS/C1720086 denotes for
T6583 8536-8541 UMLS/C1720086 denotes ded a
T6582 8909-8917 UMLS/C1554103 denotes on. Enri
T6581 9282-9290 UMLS/C1516048 denotes low cyto
T6580 9399-9404 UMLS/C1269647 denotes CD4
T6579 9330-9335 UMLS/C1269647 denotes CS Va
T6578 9272-9277 UMLS/C1269647 denotes essed
T6577 9174-9178 UMLS/C1269647 denotes nsio
T6576 9034-9039 UMLS/C1269647 denotes stain
T6575 8928-8933 UMLS/C1269647 denotes were
T6574 8671-8676 UMLS/C1269647 denotes were
T6573 8981-8987 UMLS/C1706132 denotes after
T6572 8837-8843 UMLS/C1706132 denotes . Flow
T6571 9104-9111 UMLS/C1522485 denotes with an
T6570 8815-8821 UMLS/C0424576 denotes with
T6569 8829-8833 UMLS/C0599662 denotes S co
T6568 8347-8351 UMLS/C0599662 denotes MACS
T6567 9179-9189 UMLS/C1705537 denotes ; 15 min,
T6566 9104-9111 UMLS/C1947902 denotes with an
T6565 9390-9398 UMLS/C0205409 denotes s had th
T6564 8334-8343 UMLS/C0205409 denotes isolation
T6563 9368-9372 UMLS/C0439064 denotes ) of
T6562 9064-9077 UMLS/C0031789 denotes thrin were wa
T6561 9161-9163 UMLS/C0319022 denotes of
T6560 8682-8689 UMLS/C1720119 denotes ed in 2
T6559 8627-8637 UMLS/C1621287 denotes odies were
T6558 8334-8343 UMLS/C1547129 denotes isolation
T6557 8919-8927 UMLS/C0359583 denotes ed cells
T6556 9413-9416 UMLS/C2698595 denotes rke
T6555 9155-9160 UMLS/C1883712 denotes 80 μl
T6554 8643-8648 UMLS/C1883712 denotes for
T6553 8536-8541 UMLS/C1883712 denotes ded a
T6552 9262-9268 UMLS/C1882508 denotes ls was
T6551 8327-8333 UMLS/C0039194 denotes T-cell
T6550 8963-8971 UMLS/C1510844 denotes ts from
T6549 9322-9329 UMLS/C1704680 denotes on a F
T6548 9040-9047 UMLS/C1704680 denotes d with
T6547 8707-8715 UMLS/C1704680 denotes ing buff
T6546 8485-8493 UMLS/C1704680 denotes taining
T6545 8663-8669 UMLS/C0456692 denotes n. Cel
T6544 8703-8706 UMLS/C1422082 denotes tai
T6543 8481-8484 UMLS/C1422082 denotes BS
T6542 9104-9111 UMLS/C1548779 denotes with an
T6541 8994-9001 UMLS/C0015252 denotes l from
T6540 8981-8987 UMLS/C1705246 denotes after
T6539 8837-8843 UMLS/C1705246 denotes . Flow
T6723 8939-8948 UMLS/C1516698 denotes ted in tw
T6722 8883-8892 UMLS/C1516698 denotes ted as th
T6721 9413-9416 UMLS/C1332714 denotes rke
T6720 9083-9089 UMLS/C1548982 denotes magnet
T6719 8871-8877 UMLS/C1548982 denotes were
T6718 9310-9318 UMLS/C0002778 denotes tained c
T6717 9413-9416 UMLS/C0003323 denotes rke
T6716 8829-8833 UMLS/C1416956 denotes S co
T6715 8347-8351 UMLS/C1416956 denotes MACS
T6714 8724-8732 UMLS/C1705740 denotes ted, res
T6713 8939-8948 UMLS/C1516695 denotes ted in tw
T6712 8883-8892 UMLS/C1516695 denotes ted as th
T6711 9011-9017 UMLS/C0024483 denotes . Alte
T6710 8808-8814 UMLS/C0024483 denotes fitte
T6709 8416-8428 UMLS/C1546933 denotes manufacturer
T6708 9194-9197 UMLS/C1552937 denotes C),
T6707 8563-8566 UMLS/C1552937 denotes n a
T6706 8627-8637 UMLS/C0003241 denotes odies were
T6705 8592-8599 UMLS/C1265611 denotes ts of f
T6704 9399-9404 UMLS/C1136359 denotes CD4
T6703 9330-9335 UMLS/C1136359 denotes CS Va
T6702 9272-9277 UMLS/C1136359 denotes essed
T6701 9174-9178 UMLS/C1136359 denotes nsio
T6700 9034-9039 UMLS/C1136359 denotes stain
T6699 8928-8933 UMLS/C1136359 denotes were
T6698 8671-8676 UMLS/C1136359 denotes were
T6697 8815-8821 UMLS/C0441548 denotes with
T6696 8988-8993 UMLS/C0231290 denotes remov
T6695 8994-9001 UMLS/C0728940 denotes l from
T6694 8397-8408 UMLS/C0034866 denotes recommended
T6693 8616-8626 UMLS/C0301869 denotes gated anti
T6692 9390-9398 UMLS/C1764827 denotes s had th
T6691 8334-8343 UMLS/C0204727 denotes isolation
T6690 9390-9398 UMLS/C1548221 denotes s had th
T6689 8815-8821 UMLS/C2349186 denotes with
T6688 9104-9111 UMLS/C1708632 denotes with an
T6687 9399-9404 UMLS/C1948049 denotes CD4
T6686 9330-9335 UMLS/C1948049 denotes CS Va
T6685 9272-9277 UMLS/C1948049 denotes essed
T6684 9174-9178 UMLS/C1948049 denotes nsio
T6683 9034-9039 UMLS/C1948049 denotes stain
T6682 8928-8933 UMLS/C1948049 denotes were
T6681 8671-8676 UMLS/C1948049 denotes were
T6680 9341-9345 UMLS/C0079366 denotes sort
T6679 9399-9404 UMLS/C0007634 denotes CD4
T6678 9330-9335 UMLS/C0007634 denotes CS Va
T6677 9272-9277 UMLS/C0007634 denotes essed
T6676 9174-9178 UMLS/C0007634 denotes nsio
T6675 9034-9039 UMLS/C0007634 denotes stain
T6674 8928-8933 UMLS/C0007634 denotes were
T6673 8671-8676 UMLS/C0007634 denotes were
T6672 9104-9111 UMLS/C0181496 denotes with an
T6671 9194-9197 UMLS/C0439232 denotes C),
T6670 8563-8566 UMLS/C0439232 denotes n a
T6669 9228-9237 UMLS/C1881713 denotes described
T6668 8774-8783 UMLS/C1881713 denotes ted, usua
T6667 9241-9250 UMLS/C1552738 denotes ve. The p
T6666 9341-9345 UMLS/C1517145 denotes sort
T6665 9228-9237 UMLS/C0443299 denotes described
T6664 8774-8783 UMLS/C0443299 denotes ted, usua
T6663 9155-9160 UMLS/C1524062 denotes 80 μl
T6662 8643-8648 UMLS/C1524062 denotes for
T6661 8536-8541 UMLS/C1524062 denotes ded a
T6660 9194-9197 UMLS/C0702093 denotes C),
T6659 8563-8566 UMLS/C0702093 denotes n a
T6658 9179-9189 UMLS/C1382107 denotes ; 15 min,
T6657 8682-8689 UMLS/C1948037 denotes ed in 2
T6656 8416-8428 UMLS/C1705426 denotes manufacturer
T6655 9104-9111 UMLS/C1705425 denotes with an
T6080 8197-8206 UMLS/C1516698 denotes lected an
T6079 7305-7310 UMLS/C1825592 denotes IL-17
T6078 8312-8317 UMLS/C0444504 denotes s ± S
T6077 7291-7301 UMLS/C1548180 denotes Production
T6076 8261-8264 UMLS/C0542559 denotes up
T6075 8312-8317 UMLS/C2348143 denotes s ± S
T6074 8261-8264 UMLS/C1552685 denotes up
T6073 7654-7659 UMLS/C1546774 denotes serum
T6072 8081-8088 UMLS/C0298346 denotes 8059, d
T6071 8197-8206 UMLS/C1516695 denotes lected an
T6070 7621-7633 UMLS/C2348609 denotes supplemented
T6069 7468-7481 UMLS/C0007585 denotes Cell cultures
T6068 8247-8255 UMLS/C0220814 denotes ures wer
T6067 7933-7938 UMLS/C0439275 denotes ml) w
T6066 7864-7867 UMLS/C0007012 denotes O2.
T6065 8034-8043 UMLS/C0072980 denotes amycin, c
T6064 8261-8264 UMLS/C0036849 denotes up
T6063 8176-8180 UMLS/C1136359 denotes l-fr
T6062 7969-7974 UMLS/C1136359 denotes ls we
T6061 7727-7731 UMLS/C1136359 denotes Cell
T6060 7541-7545 UMLS/C1136359 denotes cell
T6059 7670-7680 UMLS/C0030842 denotes penicillin
T6058 8234-8241 UMLS/C1510438 denotes yed. Al
T6057 7812-7819 UMLS/C0011318 denotes Denmark
T6056 8119-8124 UMLS/C0231290 denotes er in
T6055 8287-8294 UMLS/C1546471 denotes lts are
T6054 7654-7659 UMLS/C1151254 denotes serum
T6053 8176-8180 UMLS/C1948049 denotes l-fr
T6052 7969-7974 UMLS/C1948049 denotes ls we
T6051 7727-7731 UMLS/C1948049 denotes Cell
T6050 7541-7545 UMLS/C1948049 denotes cell
T6049 7958-7964 UMLS/C0439536 denotes ium an
T6048 7614-7620 UMLS/C0439536 denotes medium
T6047 8247-8255 UMLS/C0010453 denotes ures wer
T6046 8261-8264 UMLS/C0001774 denotes up
T6045 8211-8217 UMLS/C1698986 denotes red at
T6044 8176-8180 UMLS/C0007634 denotes l-fr
T6043 7969-7974 UMLS/C0007634 denotes ls we
T6042 7727-7731 UMLS/C0007634 denotes Cell
T6041 7541-7545 UMLS/C0007634 denotes cell
T6040 8287-8294 UMLS/C1280519 denotes lts are
T6039 7754-7763 UMLS/C1880359 denotes dispensed
T6038 8045-8053 UMLS/C0010467 denotes cumin, P
T6037 8261-8264 UMLS/C1442518 denotes up
T6036 7355-7365 UMLS/C0282554 denotes chemokines
T6035 7500-7509 UMLS/C1552738 denotes described
T6034 8021-8026 UMLS/C1524062 denotes ed FK
T6033 7945-7950 UMLS/C1524062 denotes ed to
T6032 8181-8185 UMLS/C0332296 denotes e me
T6031 8167-8173 UMLS/C1552743 denotes ted),
T6030 7530-7535 UMLS/C1879313 denotes brief
T6029 8090-8103 UMLS/C0011777 denotes amethasone or
T6028 7732-7742 UMLS/C1382107 denotes suspension
T6027 7546-7557 UMLS/C1382107 denotes suspensions
T6026 7643-7648 UMLS/C0015965 denotes fetal
T6025 8287-8294 UMLS/C0332294 denotes lts are
T6024 8287-8294 UMLS/C1274040 denotes lts are
T6023 8027-8032 UMLS/C0729218 denotes 06, r
T6022 8312-8317 UMLS/C0876919 denotes s ± S
T6021 7864-7867 UMLS/C0201930 denotes O2.
T6020 7452-7466 UMLS/C0007703 denotes centrifugation
T6019 7891-7905 UMLS/C0086045 denotes oncentrations
T6018 7577-7590 UMLS/C0086045 denotes concentration
T6017 8119-8124 UMLS/C0687676 denotes er in
T6016 7692-7704 UMLS/C0038425 denotes streptomycin
T6015 8299-8308 UMLS/C1171362 denotes essed as
T6014 7530-7535 UMLS/C0453896 denotes brief
T6013 8247-8255 UMLS/C2242979 denotes ures wer
T6012 7788-7794 UMLS/C0005971 denotes plates
T6011 7670-7680 UMLS/C0220892 denotes penicillin
T6010 7342-7351 UMLS/C1524094 denotes cytokines
T6009 8299-8308 UMLS/C1515670 denotes essed as
T6008 8265-8267 UMLS/C0547043 denotes n
T6007 7376-7384 UMLS/C1521827 denotes prepared
T6006 7487-7496 UMLS/C0884358 denotes performed
T6005 8061-8069 UMLS/C0251991 denotes 94002, S
T6004 7305-7310 UMLS/C1522571 denotes IL-17
T6003 7732-7742 UMLS/C0038960 denotes suspension
T6002 7546-7557 UMLS/C0038960 denotes suspensions
T6001 8234-8241 UMLS/C0005507 denotes yed. Al
T6000 8247-8255 UMLS/C0430400 denotes ures wer
T5999 7621-7633 UMLS/C1549514 denotes supplemented
T5998 8055-8059 UMLS/C0084183 denotes C, L
T5997 7366-7370 UMLS/C1321301 denotes PBMC
T5996 7649-7653 UMLS/C1305418 denotes calf
T5995 7305-7310 UMLS/C0384648 denotes IL-17
T5994 7958-7964 UMLS/C0009458 denotes ium an
T5993 7614-7620 UMLS/C0009458 denotes medium
T5992 8299-8308 UMLS/C0017262 denotes essed as
T5945 7572-7574 UMLS/C0319022 denotes to
T5944 7788-7794 UMLS/C1139930 denotes plates
T5943 8140-8148 UMLS/C0456696 denotes hours (u
T5942 7994-8002 UMLS/C0456696 denotes hours. T
T5941 7840-7848 UMLS/C0456696 denotes 24 hours
T5940 8140-8148 UMLS/C0439584 denotes hours (u
T5939 7994-8002 UMLS/C0439584 denotes hours. T
T5938 7840-7848 UMLS/C0439584 denotes 24 hours
T5937 7621-7633 UMLS/C0242295 denotes supplemented
T5936 7355-7365 UMLS/C1527036 denotes chemokines
T5935 8125-8135 UMLS/C1979572 denotes ubation fo
T5934 7321-7340 UMLS/C1514758 denotes receptor activation
T5933 7314-7329 UMLS/C0034790 denotes T cell receptor
T5932 8021-8026 UMLS/C1883712 denotes ed FK
T5931 7945-7950 UMLS/C1883712 denotes ed to
T5930 8167-8173 UMLS/C1442792 denotes ted),
T5929 8312-8317 UMLS/C2347634 denotes s ± S
T5928 8181-8185 UMLS/C1996904 denotes e me
T5927 7402-7407 UMLS/C0229664 denotes blood
T5926 7342-7351 UMLS/C0079189 denotes cytokines
T5925 7958-7964 UMLS/C1705217 denotes ium an
T5924 7614-7620 UMLS/C1705217 denotes medium
T5923 7909-7922 UMLS/C0010592 denotes yclosporin A
T5922 8312-8317 UMLS/C1704970 denotes s ± S
T5921 7654-7659 UMLS/C0229671 denotes serum
T5920 7563-7571 UMLS/C0456081 denotes adjusted
T5919 7891-7905 UMLS/C1446561 denotes oncentrations
T5918 7577-7590 UMLS/C1446561 denotes concentration
T5991 7402-7407 UMLS/C0005767 denotes blood
T5990 7402-7407 UMLS/C0005768 denotes blood
T5989 8176-8180 UMLS/C1704653 denotes l-fr
T5988 7969-7974 UMLS/C1704653 denotes ls we
T5987 7727-7731 UMLS/C1704653 denotes Cell
T5986 7541-7545 UMLS/C1704653 denotes cell
T5985 7487-7496 UMLS/C1550369 denotes performed
T5984 8012-8020 UMLS/C0031206 denotes l was ad
T5983 7402-7407 UMLS/C0392895 denotes blood
T5982 8125-8135 UMLS/C1980044 denotes ubation fo
T5981 7654-7659 UMLS/C1550100 denotes serum
T5980 8234-8241 UMLS/C0243073 denotes yed. Al
T5979 8265-8267 UMLS/C1282911 denotes n
T5978 8265-8267 UMLS/C1282910 denotes n
T5977 7621-7633 UMLS/C1947943 denotes supplemented
T5976 7643-7648 UMLS/C0521457 denotes fetal
T5975 8071-8079 UMLS/C0297666 denotes 03580, P
T5974 8167-8173 UMLS/C1301808 denotes ted),
T5973 8181-8185 UMLS/C1880497 denotes e me
T5972 7980-7989 UMLS/C1439852 denotes ubated fo
T5971 7826-7835 UMLS/C1439852 denotes incubated
T5970 7305-7310 UMLS/C1623218 denotes IL-17
T5969 8228-8233 UMLS/C1720302 denotes l ass
T5968 8271-8281 UMLS/C0205174 denotes licate, an
T5967 8107-8117 UMLS/C0078517 denotes tmannin. A
T5966 8261-8264 UMLS/C1318139 denotes up
T5965 8021-8026 UMLS/C1720086 denotes ed FK
T5964 7945-7950 UMLS/C1720086 denotes ed to
T5963 8176-8180 UMLS/C1269647 denotes l-fr
T5962 7969-7974 UMLS/C1269647 denotes ls we
T5961 7727-7731 UMLS/C1269647 denotes Cell
T5960 7541-7545 UMLS/C1269647 denotes cell
T5959 7958-7964 UMLS/C1561547 denotes ium an
T5958 7614-7620 UMLS/C1561547 denotes medium
T5957 7649-7653 UMLS/C0230445 denotes calf
T5956 7788-7794 UMLS/C0407295 denotes plates
T5955 7732-7742 UMLS/C1705537 denotes suspension
T5954 7546-7557 UMLS/C1705537 denotes suspensions
T5953 8261-8264 UMLS/C1705195 denotes up
T5952 7714-7725 UMLS/C0017797 denotes L-glutamine
T5951 8261-8264 UMLS/C1552652 denotes up
T5950 8140-8148 UMLS/C1442770 denotes hours (u
T5949 7994-8002 UMLS/C1442770 denotes hours. T
T5948 7840-7848 UMLS/C1442770 denotes 24 hours
T5947 8004-8006 UMLS/C0319022 denotes ea
T5946 7951-7953 UMLS/C0319022 denotes th
T5347 6781-6785 UMLS/C1149212 denotes wer
T5346 6478-6483 UMLS/C1825592 denotes IL-17
T5345 6604-6608 UMLS/C0079633 denotes -8 w
T5344 6492-6497 UMLS/C1149222 denotes IL-15
T5343 7032-7037 UMLS/C1719918 denotes a Che
T5342 6925-6928 UMLS/C0030779 denotes , p
T5341 6485-6490 UMLS/C1149225 denotes IL-18
T5340 7233-7240 UMLS/C0298346 denotes 059 wer
T5339 6791-6800 UMLS/C0869011 denotes hased fro
T5338 6719-6728 UMLS/C0869011 denotes chased fr
T5337 6614-6623 UMLS/C0869011 denotes rchased f
T5336 7170-7173 UMLS/C1424214 denotes Die
T5335 6667-6705 UMLS/C1527194 denotes combinant transforming growth factor (
T5334 6499-6533 UMLS/C0128897 denotes monocyte chemoattractant protein-1
T5333 6967-6976 UMLS/C0072980 denotes mycin, de
T5332 6635-6642 UMLS/C1553451 denotes stems (
T5331 6492-6497 UMLS/C0254610 denotes IL-15
T5330 6535-6540 UMLS/C1337092 denotes MCP-1
T5329 6499-6533 UMLS/C1337092 denotes monocyte chemoattractant protein-1
T5328 6595-6599 UMLS/C1149241 denotes -6 a
T5327 6891-6902 UMLS/C0039021 denotes zerland). P
T5326 7246-7254 UMLS/C1706701 denotes ined fro
T5325 7140-7148 UMLS/C1706701 denotes ined fro
T5324 7014-7022 UMLS/C1706701 denotes ined fro
T5323 7115-7134 UMLS/C0003250 denotes clonal antibody wer
T5322 7081-7100 UMLS/C0003250 denotes clonal antibody and
T5321 7201-7209 UMLS/C0297666 denotes 3580, FK
T5320 7185-7188 UMLS/C0041703 denotes . L
T5319 7066-7069 UMLS/C0041703 denotes . A
T5318 6835-6838 UMLS/C0041703 denotes . C
T5317 6661-6664 UMLS/C0041703 denotes A).
T5316 7038-7046 UMLS/C0220806 denotes ical Co.
T5315 7047-7049 UMLS/C0454802 denotes (S
T5314 6478-6483 UMLS/C1623218 denotes IL-17
T5313 6635-6642 UMLS/C0449913 denotes stems (
T5312 6758-6769 UMLS/C1514798 denotes ombinant TN
T5311 6466-6477 UMLS/C1514798 denotes Recombinant
T5310 7218-7228 UMLS/C0078517 denotes mannin and
T5309 6604-6608 UMLS/C1705592 denotes -8 w
T5308 6925-6928 UMLS/C0031858 denotes , p
T5307 6905-6923 UMLS/C0031858 denotes ohemagglutinin (PH
T5306 6996-7004 UMLS/C0010467 denotes umin wer
T5305 6485-6490 UMLS/C0383327 denotes IL-18
T5304 6492-6497 UMLS/C1334105 denotes IL-15
T5303 6595-6599 UMLS/C1527132 denotes -6 a
T5302 7246-7254 UMLS/C1301820 denotes ined fro
T5301 7140-7148 UMLS/C1301820 denotes ined fro
T5300 7014-7022 UMLS/C1301820 denotes ined fro
T5299 7032-7037 UMLS/C0227391 denotes a Che
T5298 6978-6991 UMLS/C0011777 denotes methasone and
T5297 7115-7134 UMLS/C0520150 denotes clonal antibody wer
T5296 7081-7100 UMLS/C0520150 denotes clonal antibody and
T5295 7047-7049 UMLS/C0009148 denotes (S
T5294 6485-6490 UMLS/C1334109 denotes IL-18
T5293 6543-6574 UMLS/C0376579 denotes macrophage inflammatory protein
T5292 7211-7216 UMLS/C0729218 denotes 6, wo
T5291 6457-6465 UMLS/C0034760 denotes Reagents
T5290 6859-6867 UMLS/C0359589 denotes ided by
T5289 6635-6642 UMLS/C1704459 denotes stems (
T5288 6485-6490 UMLS/C1527127 denotes IL-18
T5287 6535-6540 UMLS/C1522558 denotes MCP-1
T4844 6328-6333 UMLS/C0439234 denotes forme
T4843 6307-6312 UMLS/C0439234 denotes ange
T4842 6288-6293 UMLS/C0439234 denotes and 3
T4841 6267-6272 UMLS/C0439234 denotes (ran
T4840 5969-5974 UMLS/C0439234 denotes s). A
T4839 5948-5953 UMLS/C0439234 denotes ars (
T4838 6035-6040 UMLS/C0008972 denotes y. Co
T4837 5871-5882 UMLS/C0699792 denotes Association
T4836 6035-6040 UMLS/C0008976 denotes y. Co
T4835 6200-6204 UMLS/C0001792 denotes of
T4834 5894-5897 UMLS/C0001792 denotes age
T4833 6245-6253 UMLS/C0332298 denotes rols wer
T4832 6130-6138 UMLS/C0332298 denotes rols (3
T4831 6212-6220 UMLS/C1705908 denotes ents wit
T4830 6072-6080 UMLS/C1705908 denotes ents wit
T4829 5905-5913 UMLS/C1705908 denotes patients
T4828 5719-5727 UMLS/C1705908 denotes patients
T4827 5672-5680 UMLS/C1705908 denotes Patients
T4826 6375-6383 UMLS/C0442711 denotes as appro
T4825 6357-6365 UMLS/C1301820 denotes and the
T4824 5702-5710 UMLS/C1301820 denotes obtained
T4823 6375-6383 UMLS/C2348563 denotes as appro
T4822 6388-6396 UMLS/C1549489 denotes y the Ca
T4821 6195-6199 UMLS/C0876919 denotes age
T4820 5935-5939 UMLS/C0876919 denotes ean
T4819 6142-6145 UMLS/C1281583 denotes and
T4818 6092-6095 UMLS/C1281583 denotes and
T4817 5731-5734 UMLS/C1281583 denotes men
T4816 6433-6438 UMLS/C0020156 denotes arch
T4815 6388-6396 UMLS/C0205540 denotes y the Ca
T4814 6388-6396 UMLS/C2346846 denotes y the Ca
T4813 6142-6145 UMLS/C0086418 denotes and
T4812 6092-6095 UMLS/C0086418 denotes and
T4811 5731-5734 UMLS/C0086418 denotes men
T4810 6142-6145 UMLS/C0018563 denotes and
T4809 6092-6095 UMLS/C0018563 denotes and
T4808 5731-5734 UMLS/C0018563 denotes men
T4807 6035-6040 UMLS/C2603343 denotes y. Co
T4806 6245-6253 UMLS/C0009932 denotes rols wer
T4805 6130-6138 UMLS/C0009932 denotes rols (3
T4804 5761-5770 UMLS/C1550543 denotes fulfilled
T4803 6375-6383 UMLS/C2349977 denotes as appro
T4802 6035-6040 UMLS/C2349977 denotes y. Co
T4801 6142-6145 UMLS/C0030736 denotes and
T4800 6092-6095 UMLS/C0030736 denotes and
T4799 5731-5734 UMLS/C0030736 denotes men
T4798 5788-5796 UMLS/C0243161 denotes criteria
T4797 5998-6005 UMLS/C1522314 denotes ped 48
T4796 6212-6220 UMLS/C0030705 denotes ents wit
T4795 6072-6080 UMLS/C0030705 denotes ents wit
T4794 5905-5913 UMLS/C0030705 denotes patients
T4793 5719-5727 UMLS/C0030705 denotes patients
T4792 5672-5680 UMLS/C0030705 denotes Patients
T4791 6035-6040 UMLS/C1705923 denotes y. Co
T4790 6171-6189 UMLS/C0035435 denotes matic diseases. Th
T4789 5860-5870 UMLS/C0035435 denotes Rheumatism
T4788 5813-5820 UMLS/C0557806 denotes College
T4787 5824-5836 UMLS/C0035452 denotes Rheumatology
T4786 6022-6027 UMLS/C1705654 denotes y to
T4785 6022-6027 UMLS/C1550548 denotes y to
T4784 6245-6253 UMLS/C0243148 denotes rols wer
T4783 6130-6138 UMLS/C0243148 denotes rols (3
T4782 5998-6005 UMLS/C0450446 denotes ped 48
T4781 6142-6145 UMLS/C1690528 denotes and
T4780 6092-6095 UMLS/C1690528 denotes and
T4779 5731-5734 UMLS/C1690528 denotes men
T4778 5871-5882 UMLS/C0004083 denotes Association
T4777 6212-6220 UMLS/C1578479 denotes ents wit
T4776 6072-6080 UMLS/C1578479 denotes ents wit
T4775 5905-5913 UMLS/C1578479 denotes patients
T4774 5719-5727 UMLS/C1578479 denotes patients
T4773 5672-5680 UMLS/C1578479 denotes Patients
T4772 5851-5859 UMLS/C0596070 denotes American
T4771 5804-5812 UMLS/C0596070 denotes American
T4770 6212-6220 UMLS/C1578483 denotes ents wit
T4769 6072-6080 UMLS/C1578483 denotes ents wit
T4768 5905-5913 UMLS/C1578483 denotes patients
T4767 5719-5727 UMLS/C1578483 denotes patients
T4766 5672-5680 UMLS/C1578483 denotes Patients
T4765 6328-6333 UMLS/C1561543 denotes forme
T4764 6307-6312 UMLS/C1561543 denotes ange
T4763 6288-6293 UMLS/C1561543 denotes and 3
T4762 6267-6272 UMLS/C1561543 denotes (ran
T4761 5969-5974 UMLS/C1561543 denotes s). A
T4760 5948-5953 UMLS/C1561543 denotes ars (
T4759 6212-6220 UMLS/C1578480 denotes ents wit
T4758 6072-6080 UMLS/C1578480 denotes ents wit
T4757 5905-5913 UMLS/C1578480 denotes patients
T4756 5719-5727 UMLS/C1578480 denotes patients
T4755 5672-5680 UMLS/C1578480 denotes Patients
T4754 6212-6220 UMLS/C1578481 denotes ents wit
T4753 6072-6080 UMLS/C1578481 denotes ents wit
T4752 5905-5913 UMLS/C1578481 denotes patients
T4751 5719-5727 UMLS/C1578481 denotes patients
T4750 5672-5680 UMLS/C1578481 denotes Patients
T4749 6212-6220 UMLS/C1578486 denotes ents wit
T4748 6072-6080 UMLS/C1578486 denotes ents wit
T4747 5905-5913 UMLS/C1578486 denotes patients
T4746 5719-5727 UMLS/C1578486 denotes patients
T4745 5672-5680 UMLS/C1578486 denotes Patients
T4744 6388-6396 UMLS/C1706842 denotes y the Ca
T4743 6212-6220 UMLS/C1578484 denotes ents wit
T4742 6072-6080 UMLS/C1578484 denotes ents wit
T4741 5905-5913 UMLS/C1578484 denotes patients
T4740 5719-5727 UMLS/C1578484 denotes patients
T4739 5672-5680 UMLS/C1578484 denotes Patients
T4738 6212-6220 UMLS/C1578485 denotes ents wit
T4737 6072-6080 UMLS/C1578485 denotes ents wit
T4736 5905-5913 UMLS/C1578485 denotes patients
T4735 5719-5727 UMLS/C1578485 denotes patients
T4734 5672-5680 UMLS/C1578485 denotes Patients
T4733 6413-6423 UMLS/C0041740 denotes of Korea
T4732 5981-5992 UMLS/C0013227 denotes cations wer
T4731 5871-5882 UMLS/C0596306 denotes Association
T4730 6142-6145 UMLS/C0949399 denotes and
T4729 6092-6095 UMLS/C0949399 denotes and
T4728 5731-5734 UMLS/C0949399 denotes men
T4727 6212-6220 UMLS/C1550655 denotes ents wit
T4726 6072-6080 UMLS/C1550655 denotes ents wit
T4725 5905-5913 UMLS/C1550655 denotes patients
T4724 5719-5727 UMLS/C1550655 denotes patients
T4723 5672-5680 UMLS/C1550655 denotes Patients
T4722 5871-5882 UMLS/C0439849 denotes Association
T4721 6336-6352 UMLS/C0021430 denotes onsent was obtai
T4720 5681-5697 UMLS/C0021430 denotes Informed consent
T4719 6427-6432 UMLS/C0022771 denotes n Res
T4718 5998-6005 UMLS/C1947925 denotes ped 48
T4717 6035-6040 UMLS/C1880229 denotes y. Co
T4716 6245-6253 UMLS/C1547100 denotes rols wer
T4715 6130-6138 UMLS/C1547100 denotes rols (3
T4714 6328-6333 UMLS/C1561544 denotes forme
T4713 6307-6312 UMLS/C1561544 denotes ange
T4712 6288-6293 UMLS/C1561544 denotes and 3
T4711 6267-6272 UMLS/C1561544 denotes (ran
T4710 5969-5974 UMLS/C1561544 denotes s). A
T4709 5948-5953 UMLS/C1561544 denotes ars (
T4708 5981-5992 UMLS/C2598133 denotes cations wer
T4707 6314-6319 UMLS/C2348147 denotes –57 y
T4706 6274-6279 UMLS/C2348147 denotes 34–6
T4705 5955-5960 UMLS/C2348147 denotes nge 2
T4704 6006-6014 UMLS/C0439586 denotes ours bef
T4703 6028-6030 UMLS/C0319022 denotes he
T4702 5981-5992 UMLS/C0802604 denotes cations wer
T4701 6375-6383 UMLS/C1507394 denotes as appro
T4700 6035-6040 UMLS/C0557651 denotes y. Co
T4699 6314-6319 UMLS/C1514721 denotes –57 y
T4698 6274-6279 UMLS/C1514721 denotes 34–6
T4697 5955-5960 UMLS/C1514721 denotes nge 2
T4696 6035-6040 UMLS/C0947630 denotes y. Co
T4695 6200-6204 UMLS/C1114365 denotes of
T4694 5894-5897 UMLS/C1114365 denotes age
T4693 6195-6199 UMLS/C2347634 denotes age
T4692 5935-5939 UMLS/C2347634 denotes ean
T4691 5943-5946 UMLS/C0262878 denotes M)
T4690 6375-6383 UMLS/C1522729 denotes as appro
T4689 6042-6053 UMLS/C1707455 denotes arisons wer
T4688 6245-6253 UMLS/C1550141 denotes rols wer
T4687 6130-6138 UMLS/C1550141 denotes rols (3
T4686 6022-6027 UMLS/C1555714 denotes y to
T4685 6195-6199 UMLS/C1704970 denotes age
T4684 5935-5939 UMLS/C1704970 denotes ean
T4683 6245-6253 UMLS/C1882979 denotes rols wer
T4682 6130-6138 UMLS/C1882979 denotes rols (3
T5286 6604-6608 UMLS/C1149173 denotes -8 w
T5285 6745-6751 UMLS/C0023973 denotes don, U
T5284 6604-6608 UMLS/C1527432 denotes -8 w
T5283 6806-6813 UMLS/C0205227 denotes gen Inc
T5282 6604-6608 UMLS/C1366571 denotes -8 w
T5281 6595-6599 UMLS/C0021760 denotes -6 a
T5280 6931-6958 UMLS/C0163305 denotes olidine dithiocarbamate (PD
T5279 7191-7199 UMLS/C0251991 denotes 4002, SB
T5278 6478-6483 UMLS/C1522571 denotes IL-17
T5277 6781-6785 UMLS/C1522428 denotes wer
T5276 6595-6599 UMLS/C1334122 denotes -6 a
T5275 6781-6785 UMLS/C0021755 denotes wer
T5274 6535-6540 UMLS/C1705079 denotes MCP-1
T5273 7170-7173 UMLS/C1826357 denotes Die
T5272 6781-6785 UMLS/C0021753 denotes wer
T5271 6841-6854 UMLS/C0010592 denotes osporin A was
T5270 6960-6964 UMLS/C0084183 denotes ), r
T5269 6478-6483 UMLS/C0384648 denotes IL-17
T4871 6195-6199 UMLS/C0444504 denotes age
T4870 5935-5939 UMLS/C0444504 denotes ean
T4869 5943-5946 UMLS/C0432222 denotes M)
T4868 6195-6199 UMLS/C2348143 denotes age
T4867 5935-5939 UMLS/C2348143 denotes ean
T4866 5780-5787 UMLS/C1527075 denotes revised
T4865 6245-6253 UMLS/C2587213 denotes rols wer
T4864 6130-6138 UMLS/C2587213 denotes rols (3
T4863 5824-5836 UMLS/C0334889 denotes Rheumatology
T4862 6006-6014 UMLS/C1442464 denotes ours bef
T4861 6328-6333 UMLS/C0439508 denotes forme
T4860 6307-6312 UMLS/C0439508 denotes ange
T4859 6288-6293 UMLS/C0439508 denotes and 3
T4858 6267-6272 UMLS/C0439508 denotes (ran
T4857 5969-5974 UMLS/C0439508 denotes s). A
T4856 5948-5953 UMLS/C0439508 denotes ars (
T4855 6142-6145 UMLS/C0338831 denotes and
T4854 6092-6095 UMLS/C0338831 denotes and
T4853 5731-5734 UMLS/C0338831 denotes men
T4852 6357-6365 UMLS/C1706701 denotes and the
T4851 5702-5710 UMLS/C1706701 denotes obtained
T4850 6200-6204 UMLS/C0001811 denotes of
T4849 5894-5897 UMLS/C0001811 denotes age
T4848 5871-5882 UMLS/C1704771 denotes Association
T4847 5871-5882 UMLS/C1704770 denotes Association
T4846 6200-6204 UMLS/C0001779 denotes of
T4845 5894-5897 UMLS/C0001779 denotes age
T2747 3835-3839 UMLS/C0323983 denotes s cy
T2746 3818-3829 UMLS/C0016030 denotes roblasts [5
T2745 3267-3277 UMLS/C0016030 denotes broblast c
T2744 5168-5175 UMLS/C1527428 denotes s uncer
T2743 5194-5201 UMLS/C0449450 denotes t study
T2742 5625-5636 UMLS/C0302350 denotes utic strate
T2741 2893-2904 UMLS/C0302350 denotes herapeutic
T2740 4099-4108 UMLS/C1621983 denotes ction of
T2739 3810-3814 UMLS/C1527432 denotes 8 by
T2738 2727-2748 UP/P13296 denotes tumor necrosis factor
T2737 3174-3181 UMLS/C2348040 denotes erived
T2736 3372-3376 UMLS/C0323983 denotes s pa
T2735 3230-3236 UMLS/C0444497 denotes ints o
T2734 2649-2655 UMLS/C0444497 denotes joints
T2733 2516-2521 UMLS/C0444497 denotes joint
T2732 5513-5518 UMLS/C1825592 denotes n RA.
T2731 5016-5021 UMLS/C1825592 denotes in jo
T2730 3950-3960 UMLS/C1882134 denotes erties; se
T2729 4459-4464 UMLS/C1825592 denotes in sy
T2728 4039-4044 UMLS/C1825592 denotes 7 can
T2727 3924-3929 UMLS/C1825592 denotes 7 has
T2726 3125-3131 UMLS/C2348044 denotes eries
T2725 4687-4695 UMLS/C0700287 denotes ed to be
T2724 3063-3070 UMLS/C1704243 denotes argest
T2723 4819-4828 UMLS/C0332324 denotes ive pathw
T2722 5202-5207 UMLS/C1705923 denotes we us
T2721 5081-5088 UMLS/C1705923 denotes s [12,1
T2720 3135-3142 UMLS/C1705923 denotes tudies
T2719 4552-4566 UMLS/C0029408 denotes rthritis (OA),
T2718 2925-2931 UMLS/C0700321 denotes ittle
T2717 2681-2689 UMLS/C0205210 denotes clinical
T2716 5606-5616 UMLS/C0439755 denotes ons for ne
T2715 4893-4898 UMLS/C1423526 denotes could
T2714 3703-3708 UMLS/C1825592 denotes 17 is
T2713 4008-4020 UMLS/C0700325 denotes rvations dem
T2712 4246-4256 UMLS/C1548180 denotes tion of IL
T2711 2727-2748 UP/P59694 denotes tumor necrosis factor
T2710 5247-5263 UMLS/C1819444 denotes production in PB
T2709 5151-5167 UMLS/C1819444 denotes production remai
T2708 4932-4948 UMLS/C1819444 denotes production from
T2707 4726-4742 UMLS/C1819444 denotes production in RA
T2706 3855-3863 UMLS/C0543488 denotes erest fo
T2705 4811-4818 UMLS/C0038317 denotes d sensi
T2704 2727-2748 UP/P19101 denotes tumor necrosis factor
T2703 4921-4928 UMLS/C0032930 denotes r of IL
T2702 3950-3960 UMLS/C0871161 denotes erties; se
T2701 4715-4722 UMLS/C0032930 denotes r of IL
T2700 3518-3525 UMLS/C0003320 denotes igen sp
T2699 5621-5624 UMLS/C0205314 denotes rap
T2698 5554-5557 UMLS/C0205314 denotes igh
T2697 2889-2892 UMLS/C0205314 denotes ew
T2696 5000-5012 UMLS/C1880177 denotes bution of IL
T2695 4394-4407 UMLS/C0007589 denotes entiate and a
T2694 4503-4509 UMLS/C1299351 denotes in pa
T2693 2605-2610 UMLS/C0205309 denotes known
T2692 2727-2748 UP/O77764 denotes tumor necrosis factor
T2691 2681-2689 UMLS/C1555900 denotes clinical
T2690 5540-5545 UMLS/C0337876 denotes rovid
T2689 5440-5445 UMLS/C0337876 denotes e inv
T2688 2727-2748 UP/P51435 denotes tumor necrosis factor
T2687 3288-3297 UMLS/C0332257 denotes cluding I
T2686 5267-5271 UMLS/C1321301 denotes f pa
T2685 4785-4789 UMLS/C1321301 denotes by c
T2684 4749-4783 UMLS/C1321301 denotes eral blood mononuclear cells (PBMC
T2683 3174-3181 UMLS/C1441547 denotes erived
T2682 4829-4837 UMLS/C1704259 denotes ys [13].
T2681 2997-3015 UMLS/C0004364 denotes utoimmune disease
T2680 5532-5539 UMLS/C1546471 denotes might
T2679 5576-5588 UMLS/C0543483 denotes nesis of RA
T2678 2727-2748 UP/Q8MKG8 denotes tumor necrosis factor
T2677 3252-3262 UMLS/C0024432 denotes crophage a
T2676 2483-2494 UMLS/C0024432 denotes macrophages
T2675 4829-4837 UMLS/C1705987 denotes ys [13].
T2674 5419-5423 UMLS/C1150481 denotes Akt
T2673 3071-3075 UMLS/C0007634 denotes ell
T2672 2595-2600 UMLS/C0007634 denotes cells
T2671 2727-2748 UP/P59684 denotes tumor necrosis factor
T2670 5576-5588 UMLS/C0699748 denotes nesis of RA
T2669 3427-3439 UMLS/C0543483 denotes hogenesis of
T2668 3427-3439 UMLS/C0699748 denotes hogenesis of
T2667 2981-2993 UMLS/C0699748 denotes athogenesis
T2666 2981-2993 UMLS/C0543483 denotes athogenesis
T2665 2905-2917 UMLS/C0870325 denotes pplications
T2664 2681-2689 UMLS/C1611832 denotes clinical
T2663 3526-3534 UMLS/C1552740 denotes cific T
T2662 2925-2931 UMLS/C2700395 denotes ittle
T2661 3950-3960 UMLS/C1705419 denotes erties; se
T2660 5275-5283 UMLS/C1705908 denotes ts with
T2659 4538-4546 UMLS/C1705908 denotes ts with
T2658 4513-4521 UMLS/C1705908 denotes ts with
T2657 2727-2748 UP/P36939 denotes tumor necrosis factor
T2656 2727-2748 UP/Q8JFG3 denotes tumor necrosis factor
T2655 4655-4676 UMLS/C0001280 denotes ted macrophages, has
T2654 3950-3960 UMLS/C1705912 denotes erties; se
T2653 2536-2547 UMLS/C0020507 denotes hyperplasia
T2652 4112-4117 UMLS/C1704863 denotes L (re
T2651 3558-3574 UMLS/C0009331 denotes e II collagen, a
T2650 3063-3070 UMLS/C0443228 denotes argest
T2649 3818-3829 UMLS/C1546634 denotes roblasts [5
T2648 3267-3277 UMLS/C1546634 denotes broblast c
T2647 2727-2748 UP/P33620 denotes tumor necrosis factor
T2646 5335-5340 UMLS/C0037088 denotes that
T2645 3288-3297 UMLS/C2700399 denotes cluding I
T2644 4099-4108 UMLS/C0205263 denotes ction of
T2643 3794-3800 UMLS/C0205263 denotes uce IL
T2642 2727-2748 UP/P79374 denotes tumor necrosis factor
T2641 2527-2535 UMLS/C1550315 denotes synovial
T2640 2575-2583 UMLS/C0439180 denotes released
T2639 3810-3814 UMLS/C0079633 denotes 8 by
T2638 4503-4509 UMLS/C0205250 denotes in pa
T2637 2727-2748 UP/Q06599 denotes tumor necrosis factor
T2636 2727-2748 UP/P59695 denotes tumor necrosis factor
T2635 2727-2748 UP/P79337 denotes tumor necrosis factor
T2634 5599-5605 UMLS/C0016884 denotes direct
T2633 2727-2748 UP/P59693 denotes tumor necrosis factor
T2632 2727-2748 UP/O35734 denotes tumor necrosis factor
T2631 5532-5539 UMLS/C0332294 denotes might
T2630 5532-5539 UMLS/C1274040 denotes might
T2629 5606-5616 UMLS/C0522247 denotes ons for ne
T2628 3658-3663 UMLS/C0027552 denotes ds to
T2627 2575-2583 UMLS/C0680255 denotes released
T2626 4893-4898 UMLS/C1881122 denotes could
T2625 5335-5340 UMLS/C0243095 denotes that
T2624 2681-2689 UMLS/C1608518 denotes clinical
T2623 2727-2748 UP/P29553 denotes tumor necrosis factor
T2622 2727-2748 UP/P23563 denotes tumor necrosis factor
T2621 2727-2748 UP/Q8HZD9 denotes tumor necrosis factor
T2620 3878-3885 UMLS/C0684328 denotes sons: f
T2619 3694-3701 UMLS/C0700364 denotes ects. I
T2618 4169-4175 UMLS/C1749457 denotes ), whi
T2617 3694-3701 UMLS/C1547011 denotes ects. I
T2616 4269-4295 UP/P09056 denotes ia inhibitory factor by sy
T2615 3887-3892 UMLS/C1279901 denotes st, s
T2614 4269-4295 UP/P15018 denotes ia inhibitory factor by sy
T2613 4899-4904 UMLS/C0344312 denotes be an
T2612 4045-4048 UMLS/C0344312 denotes als
T2611 3790-3793 UMLS/C0344312 denotes in
T2610 4204-4211 UMLS/C1959609 denotes n in RA
T2609 4008-4020 UMLS/C0302523 denotes rvations dem
T2608 5073-5080 UMLS/C1279919 denotes r studi
T2607 3868-3871 UMLS/C0205448 denotes ma
T2606 5059-5069 UMLS/C1301746 denotes nted in ea
T2605 5364-5381 UMLS/C0037080 denotes ing pathway invol
T2604 5487-5490 UMLS/C1554080 denotes lam
T2603 2811-2814 UMLS/C1554080 denotes ey
T2602 4899-4904 UMLS/C0006823 denotes be an
T2601 4045-4048 UMLS/C0006823 denotes als
T2600 3790-3793 UMLS/C0006823 denotes in
T2599 3962-3968 UMLS/C0205436 denotes nd, it
T2598 4141-4148 UMLS/C0521447 denotes ear fac
T2597 3887-3892 UMLS/C0205435 denotes st, s
T2596 4341-4353 UMLS/C0028128 denotes oxide by ch
T2595 3712-3715 UMLS/C0205447 denotes of
T2594 3230-3236 UMLS/C1706309 denotes ints o
T2593 2649-2655 UMLS/C1706309 denotes joints
T2592 2516-2521 UMLS/C1706309 denotes joint
T2591 5275-5283 UMLS/C1550655 denotes ts with
T2590 4538-4546 UMLS/C1550655 denotes ts with
T2589 4513-4521 UMLS/C1550655 denotes ts with
T2588 3252-3262 UMLS/C1550652 denotes crophage a
T2587 2483-2494 UMLS/C1550652 denotes macrophages
T2586 3076-3086 UMLS/C1257890 denotes opulation
T2585 5419-5423 UMLS/C1705325 denotes Akt
T2584 2727-2748 UP/P23383 denotes tumor necrosis factor
T2583 3288-3297 UMLS/C1552866 denotes cluding I
T2582 3878-3885 UMLS/C0392360 denotes sons: f
T2581 3087-3099 UMLS/C1549537 denotes nfiltrating
T2580 3642-3646 UMLS/C1704326 denotes e of
T2579 3404-3408 UMLS/C1704326 denotes e of
T2578 4357-4369 UMLS/C0225369 denotes ocytes, and
T2577 3818-3829 UMLS/C1550637 denotes roblasts [5
T2576 3267-3277 UMLS/C1550637 denotes broblast c
T2575 2727-2748 UP/Q1G1A2 denotes tumor necrosis factor
T2574 3087-3099 UMLS/C0332448 denotes nfiltrating
T2573 2466-2479 UMLS/C0332448 denotes infiltrations
T2572 4199-4203 UMLS/C0443157 denotes rosi
T2571 4269-4295 UP/P17777 denotes ia inhibitory factor by sy
T2570 4503-4509 UMLS/C1522410 denotes in pa
T2569 4269-4295 UMLS/C1761537 denotes ia inhibitory factor by sy
T2568 2727-2748 UP/Q8WNR1 denotes tumor necrosis factor
T2567 4468-4483 UMLS/C0039097 denotes al fluids were
T2566 4616-4624 UMLS/C0039099 denotes um [11,1
T2565 3362-3370 UMLS/C0039099 denotes ovium. T
T2564 3104-3112 UMLS/C0039099 denotes ynovium.
T2563 5059-5069 UMLS/C1547673 denotes nted in ea
T2562 3200-3204 UMLS/C1522405 denotes L-2
T2561 2727-2748 UMLS/C1456820 denotes tumor necrosis factor
T2560 5194-5201 UMLS/C0150312 denotes t study
T2559 2727-2748 UP/Q9BEA1 denotes tumor necrosis factor
T2558 2905-2917 UMLS/C2347934 denotes pplications
T2557 3962-3968 UMLS/C0565930 denotes nd, it
T2556 2727-2748 UP/Q19LH4 denotes tumor necrosis factor
T2555 2449-2462 UMLS/C1880022 denotes characterized
T2554 3810-3814 UMLS/C1366571 denotes 8 by
T2553 5202-5207 UMLS/C0557651 denotes we us
T2552 5081-5088 UMLS/C0557651 denotes s [12,1
T2551 3135-3142 UMLS/C0557651 denotes tudies
T2550 4973-4980 UMLS/C0039194 denotes s [14].
T2549 4601-4608 UMLS/C0039194 denotes s in th
T2548 3988-3995 UMLS/C0039194 denotes lls [6]
T2547 3775-3782 UMLS/C0039194 denotes ells, w
T2546 3650-3657 UMLS/C0039194 denotes ells ne
T2545 3535-3542 UMLS/C0039194 denotes ells, e
T2544 5425-5428 UP/Q8INB9 denotes d N
T2543 5621-5624 UMLS/C1553390 denotes rap
T2542 5554-5557 UMLS/C1553390 denotes igh
T2541 2889-2892 UMLS/C1553390 denotes ew
T2540 5050-5053 UMLS/C2348947 denotes en
T2539 3412-3419 UMLS/C0039194 denotes ells in
T2538 3167-3173 UMLS/C0039194 denotes cell-
T2537 4678-4681 UMLS/C2348947 denotes en
T2536 4375-4378 UMLS/C2348947 denotes e a
T2489 4008-4020 UMLS/C1554188 denotes rvations dem
T2488 4893-4898 UMLS/C1149233 denotes could
T2487 5235-5246 UMLS/C1292732 denotes igate IL-17
T2486 4634-4639 UMLS/C0254610 denotes secr
T2485 3310-3315 UMLS/C0254610 denotes -15,
T2484 4260-4264 UMLS/C1149241 denotes nd l
T2483 3801-3805 UMLS/C1149241 denotes 6 an
T2482 3304-3308 UMLS/C1149241 denotes -6,
T2481 4394-4407 UMLS/C0205615 denotes entiate and a
T2480 3071-3075 UMLS/C1136359 denotes ell
T2479 2595-2600 UMLS/C1136359 denotes cells
T2478 5540-5545 UMLS/C0454788 denotes rovid
T2477 5440-5445 UMLS/C0454788 denotes e inv
T2476 3389-3399 UMLS/C1522634 denotes stioned th
T2475 2699-2707 UMLS/C1706701 denotes obtained
T2474 2727-2748 UMLS/C2700093 denotes tumor necrosis factor
T2473 4819-4828 UMLS/C1550474 denotes ive pathw
T2472 2690-2698 UMLS/C0814225 denotes benefits
T2471 3200-3204 UMLS/C0879590 denotes L-2
T2470 2905-2917 UMLS/C0185125 denotes pplications
T2469 4320-4336 UMLS/C0012472 denotes glandin E2 and n
T2468 3174-3181 UMLS/C1711343 denotes erived
T2467 3071-3075 UMLS/C1948049 denotes ell
T2466 2595-2600 UMLS/C1948049 denotes cells
T2465 2727-2748 UP/Q2MH05 denotes tumor necrosis factor
T2464 2713-2723 UMLS/C1999216 denotes inhibitors
T2463 2727-2748 UMLS/C0041368 denotes tumor necrosis factor
T2462 4412-4420 UMLS/C1879547 denotes te the d
T2461 4054-4062 UMLS/C1879547 denotes vate ost
T2460 3765-3774 UMLS/C1879547 denotes ivated T
T2459 3492-3500 UMLS/C1999177 denotes anced pr
T2458 2727-2748 UP/Q539C2 denotes tumor necrosis factor
T2457 5532-5539 UMLS/C1280519 denotes might
T2456 5202-5207 UMLS/C0008972 denotes we us
T2455 5081-5088 UMLS/C0008972 denotes s [12,1
T2454 3135-3142 UMLS/C0008972 denotes tudies
T2453 2420-2440 UMLS/C0003873 denotes Rheumatoid arthritis
T2452 4383-4390 UMLS/C0085732 denotes y to di
T2451 5202-5207 UMLS/C0008976 denotes we us
T2450 5081-5088 UMLS/C0008976 denotes s [12,1
T2449 3135-3142 UMLS/C0008976 denotes tudies
T2448 5625-5636 UMLS/C1553525 denotes utic strate
T2447 2893-2904 UMLS/C1553525 denotes herapeutic
T2446 4215-4220 UMLS/C0072944 denotes . It
T2445 5025-5043 UMLS/C0003864 denotes inflammation in RA
T2444 4634-4639 UMLS/C1334105 denotes secr
T2443 3310-3315 UMLS/C1334105 denotes -15,
T2442 2634-2645 UMLS/C1948029 denotes destruction
T2441 4260-4264 UMLS/C1527132 denotes nd l
T2371 5513-5518 UMLS/C0384648 denotes n RA.
T2440 3801-3805 UMLS/C1527132 denotes 6 an
T2439 3304-3308 UMLS/C1527132 denotes -6,
T2438 2699-2707 UMLS/C1301820 denotes obtained
T2437 2575-2583 UMLS/C1963578 denotes released
T2436 3317-3322 UMLS/C1334109 denotes -18 a
T2435 2874-2885 UMLS/C1527148 denotes evelopment
T2434 3252-3262 UMLS/C1546706 denotes crophage a
T2433 2483-2494 UMLS/C1546706 denotes macrophages
T2432 3125-3131 UMLS/C0205549 denotes eries
T2431 3317-3322 UMLS/C1527127 denotes -18 a
T2430 4231-4241 UMLS/C1948023 denotes ates the p
T2429 4425-4440 UMLS/C0011306 denotes tic cells [8-10
T2428 2727-2748 UP/P04924 denotes tumor necrosis factor
T2427 2727-2748 UP/P01375 denotes tumor necrosis factor
T2426 3810-3814 UMLS/C1149173 denotes 8 by
T2425 5059-5069 UMLS/C1548385 denotes nted in ea
T2424 5202-5207 UMLS/C2603343 denotes we us
T2423 5081-5088 UMLS/C2603343 denotes s [12,1
T2422 3135-3142 UMLS/C2603343 denotes tudies
T2421 4076-4091 UMLS/C0005974 denotes resorption by
T2420 2727-2748 UP/P16599 denotes tumor necrosis factor
T2419 3492-3500 UMLS/C2349975 denotes anced pr
T2418 5504-5512 UMLS/C1524094 denotes e IL-17
T2417 3840-3848 UMLS/C1524094 denotes okine is
T2416 3736-3745 UMLS/C1524094 denotes okines se
T2415 3617-3626 UMLS/C1524094 denotes okines in
T2414 3278-3287 UMLS/C1524094 denotes tokines i
T2413 3182-3191 UMLS/C1524094 denotes ytokines
T2412 2828-2837 UMLS/C1524094 denotes ytokines
T2411 2565-2574 UMLS/C1524094 denotes cytokines
T2410 5419-5423 UP/P42336 denotes Akt
T2409 5202-5207 UMLS/C2349977 denotes we us
T2408 5081-5088 UMLS/C2349977 denotes s [12,1
T2407 3135-3142 UMLS/C2349977 denotes tudies
T2406 4503-4509 UMLS/C1561957 denotes in pa
T2405 5621-5624 UMLS/C1578513 denotes rap
T2404 5554-5557 UMLS/C1578513 denotes igh
T2403 2889-2892 UMLS/C1578513 denotes ew
T2402 4503-4509 UMLS/C1561958 denotes in pa
T2401 4260-4264 UMLS/C0021760 denotes nd l
T2400 3801-3805 UMLS/C0021760 denotes 6 an
T2399 3304-3308 UMLS/C0021760 denotes -6,
T2398 3087-3099 UMLS/C1546677 denotes nfiltrating
T2397 3962-3968 UMLS/C0457385 denotes nd, it
T2396 4112-4117 UMLS/C1367028 denotes L (re
T2395 2763-2774 UMLS/C0021764 denotes nterleukin
T2394 5513-5518 UMLS/C1522571 denotes n RA.
T2393 5016-5021 UMLS/C1522571 denotes in jo
T2392 4459-4464 UMLS/C1522571 denotes in sy
T2391 4039-4044 UMLS/C1522571 denotes 7 can
T2390 3924-3929 UMLS/C1522571 denotes 7 has
T2389 3703-3708 UMLS/C1522571 denotes 17 is
T2388 5275-5283 UMLS/C0030705 denotes ts with
T2387 4538-4546 UMLS/C0030705 denotes ts with
T2386 4513-4521 UMLS/C0030705 denotes ts with
T2385 4260-4264 UMLS/C1334122 denotes nd l
T2384 3801-3805 UMLS/C1334122 denotes 6 an
T2383 3304-3308 UMLS/C1334122 denotes -6,
T2382 5487-5490 UMLS/C1706198 denotes lam
T2381 2811-2814 UMLS/C1706198 denotes ey
T2380 3918-3922 UMLS/C0021755 denotes , IL
T2379 3298-3302 UMLS/C0021755 denotes -1,
T2378 3918-3922 UMLS/C0021753 denotes , IL
T2377 3298-3302 UMLS/C0021753 denotes -1,
T2376 3200-3204 UMLS/C0021756 denotes L-2
T2375 5350-5363 UMLS/C0175996 denotes ellular signa
T2374 5105-5118 UMLS/C0175996 denotes ellular signa
T2373 5382-5391 UMLS/C1314939 denotes ing phosp
T2372 2727-2748 UP/P51743 denotes tumor necrosis factor
T2370 5016-5021 UMLS/C0384648 denotes in jo
T2369 4187-4195 UMLS/C1314939 denotes ed in bo
T2368 4459-4464 UMLS/C0384648 denotes in sy
T2367 4039-4044 UMLS/C0384648 denotes 7 can
T2366 3924-3929 UMLS/C0384648 denotes 7 has
T2365 5275-5283 UMLS/C1578479 denotes ts with
T2364 3703-3708 UMLS/C0384648 denotes 17 is
T2363 5449-5457 UMLS/C1314939 denotes d in the
T2362 4538-4546 UMLS/C1578479 denotes ts with
T2361 4513-4521 UMLS/C1578479 denotes ts with
T2360 5419-5423 UMLS/C1368105 denotes Akt
T2359 3071-3075 UMLS/C1704653 denotes ell
T2358 2595-2600 UMLS/C1704653 denotes cells
T2357 5275-5283 UMLS/C1578483 denotes ts with
T2356 4538-4546 UMLS/C1578483 denotes ts with
T2355 4513-4521 UMLS/C1578483 denotes ts with
T2354 5275-5283 UMLS/C1578480 denotes ts with
T2353 4538-4546 UMLS/C1578480 denotes ts with
T2352 4513-4521 UMLS/C1578480 denotes ts with
T2351 5275-5283 UMLS/C1578481 denotes ts with
T2350 4538-4546 UMLS/C1578481 denotes ts with
T2349 4513-4521 UMLS/C1578481 denotes ts with
T2348 5275-5283 UMLS/C1578486 denotes ts with
T2347 4538-4546 UMLS/C1578486 denotes ts with
T2346 4513-4521 UMLS/C1578486 denotes ts with
T2345 2799-2807 UMLS/C0332206 denotes lockade
T2344 5275-5283 UMLS/C1578484 denotes ts with
T2343 4538-4546 UMLS/C1578484 denotes ts with
T2342 4513-4521 UMLS/C1578484 denotes ts with
T2341 4204-4211 UMLS/C0333307 denotes n in RA
T2340 5275-5283 UMLS/C1578485 denotes ts with
T2339 4538-4546 UMLS/C1578485 denotes ts with
T2338 4513-4521 UMLS/C1578485 denotes ts with
T2337 2932-2936 UMLS/C0205136 denotes ver
T2336 4299-4311 UMLS/C0224522 denotes ocytes, and
T2335 2727-2748 UMLS/C1323304 denotes tumor necrosis factor
T2334 2634-2645 UMLS/C1261381 denotes destruction
T2333 2763-2774 UMLS/C1527200 denotes nterleukin
T2332 2727-2748 UP/O77510 denotes tumor necrosis factor
T2331 3230-3236 UMLS/C0392905 denotes ints o
T2330 2649-2655 UMLS/C0392905 denotes joints
T2329 2516-2521 UMLS/C0392905 denotes joint
T2328 2727-2748 UP/Q75N23 denotes tumor necrosis factor
T2327 3230-3236 UMLS/C1269611 denotes ints o
T2326 2649-2655 UMLS/C1269611 denotes joints
T2325 2516-2521 UMLS/C1269611 denotes joint
T2324 2713-2723 UMLS/C0243077 denotes inhibitors
T2323 5364-5381 UMLS/C0086982 denotes ing pathway invol
T2322 5300-5330 UMLS/C0086982 denotes ing transduction pathway. We f
T2321 5119-5146 UMLS/C0086982 denotes transduction pathway for I
T2320 4844-4852 UMLS/C0332185 denotes ly, Happ
T2319 4001-4007 UMLS/C0332185 denotes nt obs
T2318 4269-4295 UMLS/C0125606 denotes ia inhibitory factor by sy
T2317 3872-3877 UMLS/C0205164 denotes or re
T2316 5449-5457 UMLS/C1947935 denotes d in the
T2315 5382-5391 UMLS/C1947935 denotes ing phosp
T2314 4187-4195 UMLS/C1947935 denotes ed in bo
T2313 4269-4295 UP/Q27956 denotes ia inhibitory factor by sy
T2312 3950-3960 UMLS/C2347695 denotes erties; se
T2311 5513-5518 UMLS/C1623218 denotes n RA.
T2310 5016-5021 UMLS/C1623218 denotes in jo
T2309 4459-4464 UMLS/C1623218 denotes in sy
T2308 4039-4044 UMLS/C1623218 denotes 7 can
T2307 3924-3929 UMLS/C1623218 denotes 7 has
T2306 3703-3708 UMLS/C1623218 denotes 17 is
T2305 4169-4175 UMLS/C0023688 denotes ), whi
T2304 4008-4020 UMLS/C1548358 denotes rvations dem
T2303 5202-5207 UMLS/C1880229 denotes we us
T2302 5081-5088 UMLS/C1880229 denotes s [12,1
T2301 3135-3142 UMLS/C1880229 denotes tudies
T2300 3810-3814 UMLS/C1705592 denotes 8 by
T2299 5392-5408 UMLS/C0031621 denotes oinositide 3-kin
T2298 3071-3075 UMLS/C1269647 denotes ell
T2297 2595-2600 UMLS/C1269647 denotes cells
T2296 4269-4295 UP/O62728 denotes ia inhibitory factor by sy
T2295 2905-2917 UMLS/C1947919 denotes pplications
T2294 3389-3399 UMLS/C0332147 denotes stioned th
T2293 3317-3322 UMLS/C0383327 denotes -18 a
T2292 4893-4898 UMLS/C0963088 denotes could
T2291 4008-4020 UMLS/C0557985 denotes rvations dem
T2290 3694-3701 UMLS/C1879746 denotes ects. I
T2289 5606-5616 UMLS/C0700158 denotes ons for ne
T2288 4008-4020 UMLS/C1964257 denotes rvations dem
T2287 5224-5231 UMLS/C0234402 denotes i to in
T2286 2575-2583 UMLS/C1283071 denotes released
T2285 3501-3514 UMLS/C0334094 denotes liferation of
T2284 5625-5636 UMLS/C0039796 denotes utic strate
T2283 2893-2904 UMLS/C0039796 denotes herapeutic
T2282 2727-2748 UMLS/C1522668 denotes tumor necrosis factor
T2281 2782-2789 UMLS/C1705535 denotes uggest
T2280 3962-3968 UMLS/C1705190 denotes nd, it
T2279 5419-5423 UMLS/C0285761 denotes Akt
T2278 5232-5234 UMLS/C0319022 denotes es
T2277 4696-4698 UMLS/C0319022 denotes an
T2276 4391-4393 UMLS/C0319022 denotes fe
T2275 3904-3906 UMLS/C0319022 denotes TN
T2274 3664-3666 UMLS/C0319022 denotes be
T2535 3930-3933 UMLS/C2348947 denotes pro
T2534 3385-3388 UMLS/C2348947 denotes qu
T2533 2838-2841 UMLS/C2348947 denotes as
T2532 5350-5363 UMLS/C0178719 denotes ellular signa
T2531 2966-2973 UMLS/C0039194 denotes cells
T2530 5105-5118 UMLS/C0178719 denotes ellular signa
T2529 4911-4920 UMLS/C0442799 denotes ent trigg
T2528 2499-2506 UMLS/C0039194 denotes T cells
T2527 4641-4649 UMLS/C1327616 denotes ed from
T2526 3746-3754 UMLS/C1327616 denotes reted ma
T2525 3642-3646 UMLS/C1705809 denotes e of
T2524 3404-3408 UMLS/C1705809 denotes e of
T2523 3526-3534 UMLS/C0205369 denotes cific T
T2522 5606-5616 UMLS/C1550715 denotes ons for ne
T2521 3642-3646 UMLS/C1705812 denotes e of
T2520 3404-3408 UMLS/C1705812 denotes e of
T2519 3642-3646 UMLS/C1705810 denotes e of
T2518 3404-3408 UMLS/C1705810 denotes e of
T2517 3950-3960 UMLS/C1704391 denotes erties; se
T2516 3642-3646 UMLS/C1705811 denotes e of
T2515 3404-3408 UMLS/C1705811 denotes e of
T2514 3918-3922 UMLS/C1522428 denotes , IL
T2513 3298-3302 UMLS/C1522428 denotes -1,
T2512 4449-4455 UMLS/C0456079 denotes of IL
T2511 5637-5647 UMLS/C0679199 denotes ies in RA.
T2510 3230-3236 UMLS/C0022417 denotes ints o
T2509 2649-2655 UMLS/C0022417 denotes joints
T2508 2516-2521 UMLS/C0022417 denotes joint
T2507 3684-3693 UMLS/C1705242 denotes ferent as
T2506 4204-4211 UMLS/C1880549 denotes n in RA
T2505 2727-2748 UP/P06804 denotes tumor necrosis factor
T2504 5059-5069 UMLS/C1301725 denotes nted in ea
T2503 3918-3922 UMLS/C1149212 denotes , IL
T2502 3298-3302 UMLS/C1149212 denotes -1,
T2501 5606-5616 UMLS/C0449738 denotes ons for ne
T2500 5059-5069 UMLS/C1609436 denotes nted in ea
T2499 2905-2917 UMLS/C1547755 denotes pplications
T2498 4634-4639 UMLS/C1149222 denotes secr
T2497 3310-3315 UMLS/C1149222 denotes -15,
T2496 5176-5185 UMLS/C0087130 denotes ain. In t
T2495 3642-3646 UMLS/C0035820 denotes e of
T2494 3404-3408 UMLS/C0035820 denotes e of
T2493 2727-2748 UP/Q1WM27 denotes tumor necrosis factor
T2492 4449-4455 UMLS/C0441889 denotes of IL
T2491 3317-3322 UMLS/C1149225 denotes -18 a
T2490 3200-3204 UMLS/C1149229 denotes L-2
T2273 3555-3557 UMLS/C0319022 denotes ty
T2272 2611-2613 UMLS/C0319022 denotes to
T2271 3076-3086 UMLS/C0032659 denotes opulation
T2270 5546-5553 UMLS/C0359589 denotes new in
T2269 3339-3347 UMLS/C2346714 denotes ndant in
T2268 4687-4695 UMLS/C1709908 denotes ed to be
T2267 3962-3968 UMLS/C2348168 denotes nd, it
T2266 2466-2479 UMLS/C0702249 denotes infiltrations
T2265 2905-2917 UMLS/C1533134 denotes pplications
T2264 4008-4020 UMLS/C0941132 denotes rvations dem
T2263 4112-4117 UMLS/C0666364 denotes L (re
T2262 5491-5503 UMLS/C0333348 denotes atory cytoki
T2261 3723-3735 UMLS/C0333348 denotes lammatory cy
T2260 2815-2827 UMLS/C0333348 denotes nflammatory
T2259 5059-5069 UMLS/C1563337 denotes nted in ea
T2258 2727-2748 UP/P51742 denotes tumor necrosis factor
T2257 5202-5207 UMLS/C0947630 denotes we us
T2256 5081-5088 UMLS/C0947630 denotes s [12,1
T2255 3135-3142 UMLS/C0947630 denotes tudies
T2254 3962-3968 UMLS/C1561503 denotes nd, it
T2253 5625-5636 UMLS/C1547427 denotes utic strate
T2252 2893-2904 UMLS/C1547427 denotes herapeutic
T2251 4119-4127 UMLS/C0597357 denotes ptor act
T2250 2466-2479 UMLS/C1523986 denotes infiltrations
T2249 2575-2583 UMLS/C0391871 denotes released
T2248 5504-5512 UMLS/C0079189 denotes e IL-17
T2247 3840-3848 UMLS/C0079189 denotes okine is
T2246 3736-3745 UMLS/C0079189 denotes okines se
T2245 3617-3626 UMLS/C0079189 denotes okines in
T2244 3278-3287 UMLS/C0079189 denotes tokines i
T2243 3182-3191 UMLS/C0079189 denotes ytokines
T2242 2828-2837 UMLS/C0079189 denotes ytokines
T2241 2565-2574 UMLS/C0079189 denotes cytokines
T2240 4921-4928 UMLS/C1444748 denotes r of IL
T2239 4715-4722 UMLS/C1444748 denotes r of IL
T2238 4794-4806 UMLS/C0010592 denotes porine and s
T2237 4794-4806 UMLS/C0010594 denotes porine and s
T2236 2727-2748 UP/P48094 denotes tumor necrosis factor
T2235 3063-3070 UMLS/C0549177 denotes argest
T527 1815-1819 UMLS/C0323983 denotes path
T526 1615-1620 UMLS/C1825592 denotes was
T525 1274-1279 UMLS/C1825592 denotes -17 w
T524 1126-1131 UMLS/C1825592 denotes IL-17
T523 504-509 UMLS/C1825592 denotes IL-17
T522 1260-1270 UMLS/C1548180 denotes oduction o
T521 2227-2243 UMLS/C1819444 denotes oduction. These
T520 1919-1935 UMLS/C1819444 denotes roduction by act
T519 1496-1512 UMLS/C1819444 denotes -17 production (
T518 717-733 UMLS/C1819444 denotes IL-17 production
T517 648-664 UMLS/C1819444 denotes IL-17 production
T515 309-318 UMLS/C1704734 denotes regulator
T514 309-318 UMLS/C1704735 denotes regulator
T513 1012-1018 UMLS/C1551364 denotes agents
T512 173-182 UMLS/C1363844 denotes mediators
T511 1722-1727 UMLS/C1299352 denotes than
T510 708-716 UMLS/C0851285 denotes regulate
T509 639-647 UMLS/C0851285 denotes regulate
T508 554-567 UMLS/C0599779 denotes animal models
T507 1019-1028 UMLS/C0332257 denotes including
T506 357-366 UMLS/C0332257 denotes including
T505 2251-2258 UMLS/C1546471 denotes suggest
T504 1828-1836 UMLS/C1546471 denotes ted in a
T503 1820-1827 UMLS/C1705987 denotes ay resu
T502 1792-1799 UMLS/C1705987 denotes ay; act
T501 841-848 UMLS/C1705987 denotes pathway
T499 2314-2318 UMLS/C1150481 denotes and
T498 2065-2069 UMLS/C1150481 denotes inh
T497 1783-1787 UMLS/C1150481 denotes Akt
T496 831-835 UMLS/C1150481 denotes PI3K
T495 1311-1316 UMLS/C0007634 denotes lls t
T494 1378-1381 UMLS/C0031858 denotes A (
T493 1070-1073 UMLS/C0031858 denotes PHA
T492 1050-1068 UMLS/C0031858 denotes phytohemagglutinin
T491 230-242 UMLS/C0699748 denotes pathogenesis
T490 1421-1431 UMLS/C0282554 denotes emokines,
T489 1114-1124 UMLS/C0282554 denotes chemokines
T488 972-981 UMLS/C1881713 denotes separated
T487 972-981 UMLS/C0443299 denotes separated
T486 1654-1662 UMLS/C1705908 denotes nts with
T485 941-949 UMLS/C1705908 denotes patients
T483 371-380 UMLS/C0205263 denotes induction
T482 1019-1028 UMLS/C2700399 denotes including
T481 357-366 UMLS/C2700399 denotes including
T480 1722-1727 UMLS/C1611820 denotes than
T479 1722-1727 UMLS/C0205251 denotes than
T478 1317-1329 UMLS/C0332293 denotes eated with a
T477 1722-1727 UMLS/C0234886 denotes than
T476 2251-2258 UMLS/C0332294 denotes suggest
T475 1828-1836 UMLS/C0332294 denotes ted in a
T474 2251-2258 UMLS/C1274040 denotes suggest
T473 1828-1836 UMLS/C1274040 denotes ted in a
T472 610-615 UMLS/C1881122 denotes IL-23
T471 1630-1638 UMLS/C0442726 denotes ted in t
T470 2301-2310 UMLS/C0851827 denotes t on PI3K
T468 757-764 UMLS/C0449450 denotes present
T467 734-740 UMLS/C1527428 denotes remain
T466 371-380 UMLS/C1621983 denotes induction
T465 1012-1018 UMLS/C1521826 denotes agents
T464 2132-2142 UMLS/C1628982 denotes on of acti
T463 627-635 UMLS/C0700287 denotes reported
T462 1298-1307 UMLS/C0205217 denotes creased i
T460 765-770 UMLS/C1705923 denotes study
T459 1668-1682 UMLS/C0029408 denotes arthritis, but
T458 610-615 UMLS/C1423526 denotes IL-23
T457 1952-1956 UMLS/C1321301 denotes com
T456 1745-1749 UMLS/C1321301 denotes Ant
T455 1646-1650 UMLS/C1321301 denotes of p
T454 930-934 UMLS/C1321301 denotes PBMC
T453 894-928 UMLS/C1321301 denotes Peripheral blood mononuclear cells
T452 1909-1917 UMLS/C0439167 denotes y. IL-17
T451 492-500 UMLS/C0439167 denotes activity
T450 1820-1827 UMLS/C1704259 denotes ay resu
T449 1792-1799 UMLS/C1704259 denotes ay; act
T448 841-848 UMLS/C1704259 denotes pathway
T446 230-242 UMLS/C0543483 denotes pathogenesis
T445 1440-1474 UMLS/C0128897 denotes nocyte chemoattractant protein-1 a
T444 684-702 UMLS/C0037080 denotes signaling pathways
T443 2376-2379 UMLS/C1554080 denotes mma
T442 1589-1595 UMLS/C1621966 denotes th fac
T441 322-328 UMLS/C0439662 denotes immune
T440 1869-1876 UMLS/C0521447 denotes ar fact
T438 2170-2209 UMLS/C0082529 denotes lular signal-regulated kinase 1/2 did n
T437 741-748 UMLS/C1549064 denotes unknown
T436 1654-1662 UMLS/C1550655 denotes nts with
T435 941-949 UMLS/C1550655 denotes patients
T433 741-748 UMLS/C0439673 denotes unknown
T432 2301-2310 UMLS/C1701901 denotes t on PI3K
T430 2314-2318 UMLS/C1705325 denotes and
T429 2065-2069 UMLS/C1705325 denotes inh
T428 1783-1787 UMLS/C1705325 denotes Akt
T427 831-835 UMLS/C1705325 denotes PI3K
T426 1019-1028 UMLS/C1552866 denotes including
T425 357-366 UMLS/C1552866 denotes including
T424 2084-2094 UMLS/C0078517 denotes in and LY2
T423 792-796 UMLS/C1704326 denotes role
T422 1400-1406 UMLS/C0392366 denotes sted c
T421 538-546 UMLS/C0039099 denotes synovium
T420 741-748 UMLS/C1548550 denotes unknown
T419 1909-1917 UMLS/C0441655 denotes y. IL-17
T418 492-500 UMLS/C0441655 denotes activity
T417 741-748 UMLS/C1549105 denotes unknown
T416 2132-2142 UMLS/C0021467 denotes on of acti
T415 2132-2142 UMLS/C0021469 denotes on of acti
T414 741-748 UMLS/C1548543 denotes unknown
T413 1996-2004 UMLS/C0150312 denotes e of the
T412 757-764 UMLS/C0150312 denotes present
T411 1717-1721 UMLS/C0439064 denotes lowe
T410 2170-2209 UP/P42525 denotes lular signal-regulated kinase 1/2 did n
T409 1400-1406 UMLS/C0183885 denotes sted c
T408 1421-1431 UMLS/C1527036 denotes emokines,
T407 1114-1124 UMLS/C1527036 denotes chemokines
T406 2319-2322 UP/Q8INB9 denotes NF-
T405 2070-2073 UP/Q8INB9 denotes bit
T404 1788-1791 UP/Q8INB9 denotes ath
T403 837-840 UP/Q8INB9 denotes Akt
T401 510-513 UMLS/C2348947 denotes has
T400 670-683 UMLS/C0178719 denotes intracellular
T399 856-886 UMLS/C1819484 denotes regulation of IL-17 production
T398 1298-1307 UMLS/C0442805 denotes creased i
T396 765-770 UMLS/C0557651 denotes study
T395 1298-1307 UMLS/C0442808 denotes creased i
T393 792-796 UMLS/C1705809 denotes role
T392 792-796 UMLS/C1705812 denotes role
T391 741-748 UMLS/C1549625 denotes unknown
T390 1853-1865 UMLS/C0332509 denotes ntation of n
T389 792-796 UMLS/C1705810 denotes role
T388 792-796 UMLS/C1705811 denotes role
T387 1705-1711 UMLS/C0456079 denotes s were
T386 1132-1138 UMLS/C0456079 denotes levels
T385 741-748 UMLS/C1548502 denotes unknown
T384 741-748 UMLS/C1549115 denotes unknown
T383 1012-1018 UMLS/C1254351 denotes agents
T382 1751-1768 UMLS/C0879551 denotes CD3 antibody acti
T381 1330-1347 UMLS/C0879551 denotes ti-CD3 antibody w
T380 1576-1588 UMLS/C1510411 denotes sforming gro
T379 1433-1438 UMLS/C1149222 denotes -15,
T378 600-605 UMLS/C1149222 denotes IL-15
T377 1378-1381 UMLS/C0030779 denotes A (
T376 1070-1073 UMLS/C0030779 denotes PHA
T375 792-796 UMLS/C0035820 denotes role
T374 1705-1711 UMLS/C0441889 denotes s were
T373 1132-1138 UMLS/C0441889 denotes levels
T372 1567-1572 UMLS/C1149225 denotes 8 or
T371 2170-2209 UP/P21708 denotes lular signal-regulated kinase 1/2 did n
T370 610-615 UMLS/C1149233 denotes IL-23
T369 775-787 UMLS/C1292732 denotes investigated
T368 1433-1438 UMLS/C0254610 denotes -15,
T367 600-605 UMLS/C0254610 denotes IL-15
T365 1479-1483 UMLS/C1149241 denotes -6 u
T364 1311-1316 UMLS/C1136359 denotes lls t
T363 1694-1704 UMLS/C0185117 denotes ssion leve
T362 461-471 UMLS/C0185117 denotes expression
T361 741-748 UMLS/C1609613 denotes unknown
T360 1722-1727 UMLS/C1550472 denotes than
T359 1205-1212 UMLS/C1555029 denotes reverse
T358 741-748 UMLS/C1556128 denotes unknown
T285 1615-1620 UMLS/C0384648 denotes was
T284 1274-1279 UMLS/C0384648 denotes -17 w
T283 1126-1131 UMLS/C0384648 denotes IL-17
T282 504-509 UMLS/C0384648 denotes IL-17
T281 1576-1588 UMLS/C0040682 denotes sforming gro
T280 2338-2346 UMLS/C1314939 denotes in the o
T279 2220-2226 UMLS/C1314939 denotes L-17 p
T278 1654-1662 UMLS/C1578479 denotes nts with
T277 941-949 UMLS/C1578479 denotes patients
T275 1909-1917 UMLS/C1561536 denotes y. IL-17
T274 492-500 UMLS/C1561536 denotes activity
T273 2314-2318 UMLS/C1368105 denotes and
T272 2065-2069 UMLS/C1368105 denotes inh
T271 1783-1787 UMLS/C1368105 denotes Akt
T270 831-835 UMLS/C1368105 denotes PI3K
T269 1694-1704 UMLS/C0017262 denotes ssion leve
T268 461-471 UMLS/C0017262 denotes expression
T267 1311-1316 UMLS/C1704653 denotes lls t
T266 1654-1662 UMLS/C1578483 denotes nts with
T265 941-949 UMLS/C1578483 denotes patients
T263 1654-1662 UMLS/C1578480 denotes nts with
T262 941-949 UMLS/C1578480 denotes patients
T260 1654-1662 UMLS/C1578481 denotes nts with
T259 941-949 UMLS/C1578481 denotes patients
T257 741-748 UMLS/C1561529 denotes unknown
T256 1654-1662 UMLS/C1578486 denotes nts with
T255 941-949 UMLS/C1578486 denotes patients
T253 1144-1154 UMLS/C0521095 denotes determined
T252 1654-1662 UMLS/C1578484 denotes nts with
T251 941-949 UMLS/C1578484 denotes patients
T249 1981-1988 UMLS/C0332206 denotes in the
T248 1400-1406 UMLS/C0022885 denotes sted c
T247 1654-1662 UMLS/C1578485 denotes nts with
T246 941-949 UMLS/C1578485 denotes patients
T244 1981-1988 UMLS/C1706084 denotes in the
T243 273-284 UMLS/C1527200 denotes Interleukin
T242 1229-1254 UMLS/C0032520 denotes lymerase chain reaction.
T241 2074-2083 UMLS/C0243077 denotes r wortman
T240 2019-2028 UMLS/C0243077 denotes r pyrroli
T239 741-748 UMLS/C1547312 denotes unknown
T238 1400-1406 UMLS/C0013702 denotes sted c
T237 1722-1727 UMLS/C0441994 denotes than
T236 1440-1474 UMLS/C1337092 denotes nocyte chemoattractant protein-1 a
T235 2272-2300 UMLS/C0086982 denotes ransduction pathways depende
T234 684-702 UMLS/C0086982 denotes signaling pathways
T233 972-981 UMLS/C0086972 denotes separated
T232 741-748 UMLS/C1548340 denotes unknown
T231 1853-1865 UMLS/C1293122 denotes ntation of n
T230 2338-2346 UMLS/C1947935 denotes in the o
T229 1400-1406 UMLS/C0039593 denotes sted c
T228 1722-1727 UMLS/C1708760 denotes than
T227 1981-1988 UMLS/C1533157 denotes in the
T226 1615-1620 UMLS/C1623218 denotes was
T225 1274-1279 UMLS/C1623218 denotes -17 w
T224 1126-1131 UMLS/C1623218 denotes IL-17
T223 504-509 UMLS/C1623218 denotes IL-17
T222 765-770 UMLS/C1880229 denotes study
T221 804-820 UMLS/C0031621 denotes phosphoinositide
T219 1311-1316 UMLS/C1269647 denotes lls t
T218 1722-1727 UMLS/C1619811 denotes than
T217 1567-1572 UMLS/C0383327 denotes 8 or
T216 610-615 UMLS/C0963088 denotes IL-23
T215 741-748 UMLS/C1546837 denotes unknown
T214 1722-1727 UMLS/C1548802 denotes than
T213 741-748 UMLS/C1546841 denotes unknown
T212 2259-2266 UMLS/C1705535 denotes that si
T211 2170-2209 UP/P28869 denotes lular signal-regulated kinase 1/2 did n
T210 1684-1687 UMLS/C0005341 denotes hei
T209 2314-2318 UMLS/C0285761 denotes and
T208 2065-2069 UMLS/C0285761 denotes inh
T207 1783-1787 UMLS/C0285761 denotes Akt
T206 831-835 UMLS/C0285761 denotes PI3K
T205 173-182 UMLS/C0127400 denotes mediators
T204 636-638 UMLS/C0319022 denotes to
T203 1589-1595 UMLS/C0018270 denotes th fac
T202 2220-2226 UMLS/C0392760 denotes L-17 p
T201 1981-1988 UMLS/C0028778 denotes in the
T200 627-635 UMLS/C1709908 denotes reported
T199 2170-2209 UP/Q63844 denotes lular signal-regulated kinase 1/2 did n
T198 1533-1547 UMLS/C0333516 denotes mor necrosis f
T197 444-456 UMLS/C0332120 denotes Evidence for
T196 1981-1988 UMLS/C0233660 denotes in the
T195 2380-2392 UMLS/C0333348 denotes ory cytokine
T194 1087-1099 UMLS/C0333348 denotes inflammatory
T193 160-172 UMLS/C0333348 denotes Inflammatory
T192 765-770 UMLS/C0947630 denotes study
T191 2393-2401 UMLS/C0079189 denotes IL-17 in
T190 1407-1416 UMLS/C0079189 denotes tokines a
T189 1100-1109 UMLS/C0079189 denotes cytokines
T188 589-598 UMLS/C0079189 denotes cytokines
T187 400-409 UMLS/C0079189 denotes cytokines
T186 2146-2165 UMLS/C0085828 denotes r protein-1 and ext
T185 1897-1908 UMLS/C1148673 denotes ding activi
T357 741-748 UMLS/C1556127 denotes unknown
T356 1311-1316 UMLS/C1948049 denotes lls t
T355 741-748 UMLS/C1556130 denotes unknown
T354 741-748 UMLS/C1556129 denotes unknown
T353 2074-2083 UMLS/C1999216 denotes r wortman
T352 2019-2028 UMLS/C1999216 denotes r pyrroli
T351 1630-1638 UMLS/C1511790 denotes ted in t
T350 741-748 UMLS/C1556132 denotes unknown
T349 741-748 UMLS/C1556131 denotes unknown
T348 1939-1948 UMLS/C1879547 denotes ed RA PBM
T347 1801-1811 UMLS/C1879547 denotes ation of t
T346 1769-1778 UMLS/C1879547 denotes ated the
T345 741-748 UMLS/C1556134 denotes unknown
T344 741-748 UMLS/C1556133 denotes unknown
T343 2251-2258 UMLS/C1280519 denotes suggest
T342 1828-1836 UMLS/C1280519 denotes ted in a
T341 741-748 UMLS/C1556136 denotes unknown
T340 1589-1595 UMLS/C1457898 denotes th fac
T339 741-748 UMLS/C1556135 denotes unknown
T338 765-770 UMLS/C0008972 denotes study
T337 246-266 UMLS/C0003873 denotes rheumatoid arthritis
T335 741-748 UMLS/C1556137 denotes unknown
T334 765-770 UMLS/C0008976 denotes study
T333 1433-1438 UMLS/C1334105 denotes -15,
T332 600-605 UMLS/C1334105 denotes IL-15
T331 1479-1483 UMLS/C1527132 denotes -6 u
T330 741-748 UMLS/C1556125 denotes unknown
T329 741-748 UMLS/C1556126 denotes unknown
T328 741-748 UMLS/C1556123 denotes unknown
T327 2170-2209 UP/P27361 denotes lular signal-regulated kinase 1/2 did n
T326 741-748 UMLS/C1556124 denotes unknown
T325 741-748 UMLS/C1556121 denotes unknown
T324 1567-1572 UMLS/C1334109 denotes 8 or
T323 741-748 UMLS/C1556122 denotes unknown
T322 741-748 UMLS/C1556120 denotes unknown
T321 2220-2226 UMLS/C0001721 denotes L-17 p
T320 1567-1572 UMLS/C1527127 denotes 8 or
T319 988-998 UMLS/C1948023 denotes stimulated
T318 333-355 UMLS/C1155266 denotes inflammatory responses
T317 765-770 UMLS/C2603343 denotes study
T316 427-442 UMLS/C0005974 denotes bone resorption
T315 741-748 UMLS/C1547294 denotes unknown
T314 2393-2401 UMLS/C1524094 denotes IL-17 in
T313 1407-1416 UMLS/C1524094 denotes tokines a
T312 1100-1109 UMLS/C1524094 denotes cytokines
T311 589-598 UMLS/C1524094 denotes cytokines
T310 400-409 UMLS/C1524094 denotes cytokines
T309 2314-2318 UP/P42336 denotes and
T308 2065-2069 UP/P42336 denotes inh
T307 1783-1787 UP/P42336 denotes Akt
T306 831-835 UP/P42336 denotes PI3K
T305 1167-1200 UMLS/C0014441 denotes enzyme-linked immunosorbent assay
T304 765-770 UMLS/C2349977 denotes study
T303 1479-1483 UMLS/C0021760 denotes -6 u
T302 2029-2056 UMLS/C0163305 denotes ine dithiocarbamate and the
T301 2099-2107 UMLS/C0251991 denotes , respec
T300 273-284 UMLS/C0021764 denotes Interleukin
T299 1615-1620 UMLS/C1522571 denotes was
T298 1274-1279 UMLS/C1522571 denotes -17 w
T297 1126-1131 UMLS/C1522571 denotes IL-17
T296 504-509 UMLS/C1522571 denotes IL-17
T295 741-748 UMLS/C1547306 denotes unknown
T294 1654-1662 UMLS/C0030705 denotes nts with
T293 941-949 UMLS/C0030705 denotes patients
T291 1996-2004 UMLS/C0392148 denotes e of the
T290 1479-1483 UMLS/C1334122 denotes -6 u
T289 2376-2379 UMLS/C1706198 denotes mma
T288 670-683 UMLS/C0175996 denotes intracellular
T287 741-748 UMLS/C1547283 denotes unknown
T286 1012-1018 UMLS/C0450442 denotes agents

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T664 0-9 VB denotes Increased
T665 10-24 NN denotes interleukin-17
T666 25-35 NN denotes production
T667 36-39 IN denotes via
T668 40-41 DT denotes a
T669 42-58 NN denotes phosphoinositide
T670 59-71 NN denotes 3-kinase/Akt
T671 72-75 CC denotes and
T672 76-83 JJ denotes nuclear
T673 84-90 NN denotes factor
T674 91-102 JJ denotes κB-dependen
T675 102-109 NN denotes t pathw
T676 109-111 IN denotes ay
T677 112-120 NN denotes in patie
T678 120-124 IN denotes nts
T679 124-134 JJ denotes with rheum
T680 134-143 NN denotes atoid art
T22341 28793-28795 NN denotes RA
T22340 28790-28792 IN denotes in
T22339 28777-28789 NN denotes applications
T22338 28765-28776 JJ denotes therapeutic
T22337 28761-28764 JJ denotes new
T22336 28758-28760 IN denotes of
T22335 28748-28757 NN denotes targeting
T22334 28738-28747 JJ denotes molecular
T22333 28731-28737 JJ denotes future
T22332 28727-28730 DT denotes the
T22331 28723-28726 IN denotes for
T22330 28711-28722 NN denotes information
T22329 28705-28710 VB denotes added
T22328 28700-28704 VB denotes have
T22327 28692-28699 NN denotes results
T22326 28688-28691 PRP-DOLLAR- denotes our
T22325 28686-28687 -COMMA- denotes ,
T22324 28684-28686 NN denotes RA
T22323 28681-28683 IN denotes in
T22322 28670-28680 NN denotes anti-IL-17
T22321 28667-28669 IN denotes of
T22320 28654-28666 NN denotes introduction
T22319 28643-28653 JJ denotes successful
T22318 28639-28642 DT denotes the
T22317 28636-28638 IN denotes on
T22316 28631-28635 NN denotes data
T22315 28624-28630 JJ denotes recent
T22314 28619-28623 IN denotes with
T22313 28610-28618 RB denotes Together
T22312 28596-28608 NN denotes pathogenesis
T22311 28593-28595 NN denotes RA
T22310 28590-28592 IN denotes in
T22309 28580-28589 VB denotes neglected
T22308 28575-28579 VB denotes been
T22307 28566-28574 RB denotes hitherto
T22306 28562-28565 VB denotes has
T22305 28556-28561 WDT denotes which
T22304 28554-28555 -COMMA- denotes ,
T22303 28549-28554 NN denotes cells
T22302 28547-28548 NN denotes T
T22301 28544-28546 IN denotes of
T22300 28539-28543 NN denotes role
T22299 28535-28538 DT denotes the
T22298 28525-28534 VB denotes highlight
T22297 28521-28524 CC denotes and
T22296 28519-28520 -COMMA- denotes ,
T22295 28517-28519 NN denotes RA
T22294 28514-28516 IN denotes in
T22293 28503-28513 NN denotes production
T22292 28497-28502 NN denotes IL-17
T22291 28494-28496 IN denotes of
T22290 28483-28493 NN denotes regulation
T22289 28479-28482 DT denotes the
T22288 28476-28478 IN denotes of
T22287 28465-28475 NN denotes mechanisms
T22286 28456-28464 JJ denotes cellular
T22285 28451-28455 IN denotes into
T22284 28442-28450 NN denotes insights
T22283 28434-28441 VB denotes provide
T22282 28429-28433 NN denotes data
T22281 28425-28428 PRP-DOLLAR- denotes Our
T22280 28413-28423 NN denotes activation
T22279 28407-28412 NN denotes NF-κB
T22278 28397-28406 JJ denotes resultant
T22277 28392-28396 IN denotes with
T22276 28384-28391 NN denotes pathway
T22275 28375-28383 NN denotes PI3K/Akt
T22274 28371-28374 DT denotes the
T22273 28367-28370 IN denotes via
T22272 28356-28366 NN denotes activation
T22271 28353-28355 IN denotes of
T22270 28346-28352 NN denotes result
T22269 28342-28345 DT denotes the
T22268 28339-28341 VB denotes be
T22267 28333-28338 MD denotes could
T22266 28330-28332 NN denotes RA
T22265 28325-28329 IN denotes with
T22264 28316-28324 NN denotes patients
T22263 28313-28315 IN denotes in
T22262 28307-28312 NN denotes cells
T22261 28305-28306 NN denotes T
T22260 28295-28304 VB denotes activated
T22259 28292-28294 IN denotes by
T22258 28286-28291 NN denotes IL-17
T22257 28283-28285 IN denotes of
T22256 28270-28282 NN denotes upregulation
T22255 28265-28269 IN denotes that
T22254 28259-28264 VB denotes shown
T22253 28254-28258 RB denotes also
T22252 28249-28253 VB denotes have
T22251 28246-28248 PRP denotes We
T22250 28226-28244 JJ denotes anti-CD3/anti-CD28
T22249 28223-28225 IN denotes by
T22248 28211-28222 NN denotes stimulation
T22247 28208-28210 IN denotes as
T22246 28203-28207 RB denotes well
T22245 28200-28202 RB denotes as
T22244 28194-28199 NN denotes MCP-1
T22243 28190-28193 CC denotes and
T22242 28184-28189 NN denotes IL-15
T22241 28181-28183 TO denotes to
T22240 28172-28180 NN denotes response
T22239 28169-28171 IN denotes in
T22238 28164-28168 NN denotes PBMC
T22237 28161-28163 NN denotes RA
T22236 28156-28160 IN denotes from
T22235 28150-28155 NN denotes IL-17
T22234 28147-28149 IN denotes of
T22233 28136-28146 NN denotes production
T22232 28125-28135 JJ denotes pronounced
T22231 28120-28124 RB denotes more
T15054 20175-20177 IN denotes of
T19436 28084-28086 NN denotes RA
T19435 28081-28083 IN denotes in
T19434 28071-28080 NN denotes therapies
T19433 28062-28070 VB denotes targeted
T19432 28058-28061 JJ denotes new
T19431 28047-28057 VB denotes developing
T19430 28044-28046 IN denotes of
T19429 28036-28043 NN denotes element
T19428 28026-28035 JJ denotes important
T19427 28023-28025 DT denotes an
T19426 28020-28022 VB denotes is
T19425 28012-28019 NN denotes pathway
T19424 28002-28011 NN denotes signaling
T19423 27996-28001 NN denotes IL-17
T19422 27992-27995 DT denotes the
T19421 27978-27991 VB denotes understanding
T19420 27976-27977 -COMMA- denotes ,
T19419 27975-27976 -RRB- denotes ]
T19418 27966-27975 CD denotes 2,6,34-36
T19417 27965-27966 -LRB- denotes [
T19416 27958-27964 NN denotes models
T19415 27951-27957 NN denotes animal
T19414 27948-27950 IN denotes in
T19413 27938-27947 NN denotes arthritis
T19412 27925-27937 VB denotes ameliorating
T19411 27921-27924 IN denotes for
T19410 27910-27920 NN denotes anti-IL-17
T19409 27907-27909 IN denotes of
T19408 27897-27906 NN denotes induction
T19407 27886-27896 JJ denotes successful
T19406 27882-27885 CC denotes and
T19405 27871-27881 NN denotes activities
T19404 27855-27870 JJ denotes proinflammatory
T19403 27851-27854 PRP-DOLLAR- denotes its
T19402 27839-27850 VB denotes Considering
T19401 27829-27837 NN denotes LY294002
T19400 27825-27828 CC denotes and
T19395 27798-27801 DT denotes the
T19394 27795-27797 IN denotes in
T19393 27786-27794 NN denotes activity
T19392 27778-27785 NN denotes binding
T19391 27772-27777 NN denotes NF-κB
T19390 27769-27771 IN denotes of
T19389 27760-27768 NN denotes blocking
T19388 27747-27759 JJ denotes simultaneous
T19387 27739-27746 VB denotes showing
T19386 27727-27738 NN denotes experiments
T19385 27723-27726 PRP-DOLLAR- denotes our
T19384 27720-27722 IN denotes of
T19383 27714-27719 NN denotes basis
T19382 27710-27713 DT denotes the
T19381 27707-27709 IN denotes on
T19380 27705-27706 -COMMA- denotes ,
T19379 27703-27705 NN denotes RA
T19378 27700-27702 IN denotes in
T19377 27694-27699 NN denotes IL-17
T19376 27691-27693 IN denotes of
T19375 27678-27690 NN denotes upregulation
T19374 27674-27677 DT denotes the
T19373 27671-27673 IN denotes of
T19372 27660-27670 NN denotes arbitrator
T19371 27650-27659 JJ denotes important
T19370 27647-27649 DT denotes an
T19369 27644-27646 VB denotes be
T19368 27638-27643 MD denotes could
T19367 27627-27637 NN denotes activation
T19366 27621-27626 NN denotes NF-κB
T19365 27611-27620 JJ denotes resultant
T19364 27607-27610 CC denotes and
T19363 27598-27606 NN denotes PI3K/Akt
T19362 27593-27597 IN denotes that
T19361 27580-27592 VB denotes demonstrated
T19360 27572-27579 RB denotes clearly
T19359 27567-27571 NN denotes data
T19358 27563-27566 PRP-DOLLAR- denotes Our
T19357 27554-27561 VB denotes lacking
T19356 27550-27553 VB denotes are
T19355 27544-27549 NN denotes IL-17
T19354 27535-27543 VB denotes inducing
T19353 27528-27534 NN denotes signal
T19352 27524-27527 DT denotes the
T19351 27521-27523 IN denotes on
T19350 27516-27520 NN denotes data
T19349 27512-27515 DT denotes the
T19348 27510-27511 -COMMA- denotes ,
T19347 27505-27510 NN denotes types
T19346 27500-27504 NN denotes cell
T19345 27495-27499 JJ denotes many
T19344 27492-27494 IN denotes in
T19343 27484-27491 NN denotes signals
T19342 27473-27483 VB denotes activating
T19341 27465-27472 VB denotes deliver
T19340 27462-27464 TO denotes to
T19339 27453-27461 VB denotes reported
T19338 27448-27452 VB denotes been
T19337 27443-27447 VB denotes have
T19336 27437-27442 NN denotes NF-κB
T19335 27432-27436 IN denotes with
T19334 27420-27431 NN denotes association
T19333 27417-27419 IN denotes in
T19332 27413-27416 NN denotes Akt
T19331 27406-27412 NN denotes kinase
T19330 27395-27405 JJ denotes downstream
T19329 27391-27394 PRP-DOLLAR- denotes its
T19328 27387-27390 CC denotes and
T19327 27382-27386 NN denotes PI3K
T19326 27373-27381 IN denotes Although
T19325 27370-27371 -RRB- denotes )
T19324 27365-27370 VB denotes shown
T19323 27361-27364 RB denotes not
T19322 27356-27360 NN denotes data
T19321 27355-27356 -LRB- denotes (
T19320 27343-27354 NN denotes experiments
T19319 27339-27342 PRP-DOLLAR- denotes our
T19318 27336-27338 IN denotes in
T19317 27326-27335 VB denotes activated
T19316 27322-27325 RB denotes not
T19315 27318-27321 VB denotes was
T19314 27316-27317 -COMMA- denotes ,
T19313 27296-27316 NN denotes cytokines/chemokines
T19312 27292-27295 IN denotes for
T19311 27284-27291 NN denotes pathway
T19310 27274-27283 NN denotes signaling
T19309 27264-27273 JJ denotes important
T19308 27256-27263 DT denotes another
T19307 27254-27255 -COMMA- denotes ,
T19306 27247-27254 NN denotes pathway
T19305 27234-27246 NN denotes transduction
T19304 27227-27233 NN denotes signal
T19303 27222-27226 NN denotes AP-1
T19302 27218-27221 DT denotes the
T19301 27216-27217 -COMMA- denotes ,
T19300 27208-27216 NN denotes contrast
T19299 27205-27207 IN denotes In
T19298 27199-27203 NN denotes PBMC
T19297 27196-27198 NN denotes RA
T19296 27193-27195 IN denotes in
T19295 27187-27192 NN denotes IL-17
T19294 27184-27186 IN denotes of
T19293 27174-27183 NN denotes induction
T19292 27170-27173 DT denotes the
T19291 27167-27169 IN denotes in
T19290 27158-27166 VB denotes involved
T19289 27149-27157 RB denotes actively
T19288 27144-27148 RB denotes also
T19287 27141-27143 VB denotes is
T19286 27133-27140 NN denotes pathway
T19285 27127-27132 NN denotes NF-κB
T19284 27123-27126 DT denotes the
T19283 27118-27122 IN denotes that
T19282 27111-27117 JJ denotes likely
T19281 27106-27110 RB denotes most
T19280 27103-27105 VB denotes is
T19279 27100-27102 PRP denotes it
T19278 27098-27099 -COMMA- denotes ,
T19277 27087-27098 NN denotes experiments
T19276 27083-27086 PRP-DOLLAR- denotes our
T19275 27080-27082 IN denotes in
T19274 27071-27079 NN denotes mitogens
T19273 27068-27070 CC denotes or
T19272 27062-27067 NN denotes IL-15
T19271 27060-27061 -COMMA- denotes ,
T19270 27042-27060 JJ denotes anti-CD3/anti-CD28
T19269 27039-27041 IN denotes by
T19268 27029-27038 VB denotes activated
T19267 27024-27028 RB denotes also
T19266 27020-27023 VB denotes was
T19265 27014-27019 NN denotes NF-κB
T19264 27009-27013 IN denotes that
T19263 27004-27008 NN denotes fact
T19262 27000-27003 DT denotes the
T19261 26997-26999 IN denotes of
T19260 26992-26996 NN denotes view
T19259 26989-26991 IN denotes In
T19258 26985-26987 NN denotes RA
T19257 26982-26984 IN denotes in
T19256 26976-26981 NN denotes IL-17
T19255 26973-26975 IN denotes of
T19254 26963-26972 NN denotes induction
T19253 26959-26962 DT denotes the
T19252 26956-26958 IN denotes in
T19251 26951-26955 NN denotes PI3K
T19250 26948-26950 IN denotes of
T19249 26936-26947 NN denotes involvement
T19248 26927-26935 JJ denotes possible
T19247 26923-26926 DT denotes the
T19246 26914-26922 VB denotes suggests
T19245 26902-26913 NN denotes stimulation
T19244 26893-26901 JJ denotes anti-CD3
T19243 26888-26892 IN denotes upon
T19242 26873-26887 VB denotes phosphorylated
T19241 26870-26872 VB denotes is
T19240 26866-26869 NN denotes Akt
T19239 26861-26865 IN denotes that
T19238 26856-26860 NN denotes fact
T19237 26852-26855 DT denotes The
T19236 26845-26850 NN denotes hours
T19235 26843-26844 CD denotes 2
T19234 26840-26842 IN denotes at
T19233 26831-26839 NN denotes activity
T19232 26828-26830 IN denotes of
T19231 26823-26827 NN denotes loss
T19230 26815-26822 JJ denotes gradual
T19229 26813-26814 DT denotes a
T19228 26809-26812 CC denotes and
T19227 26804-26808 NN denotes hour
T19226 26802-26803 CD denotes 1
T19225 26799-26801 IN denotes at
T19224 26788-26798 NN denotes activation
T19223 26784-26787 NN denotes Akt
T19222 26781-26783 IN denotes of
T19221 26772-26780 NN denotes response
T19220 26764-26771 JJ denotes maximal
T19219 26762-26763 DT denotes a
T19218 26757-26761 VB denotes have
T19217 26754-26756 TO denotes to
T19216 26747-26753 VB denotes seemed
T19215 26742-26746 NN denotes PI3K
T19214 26739-26741 IN denotes of
T19213 26731-26738 NN denotes pathway
T19212 26720-26730 JJ denotes downstream
T19211 26718-26719 DT denotes a
T19210 26714-26717 IN denotes for
T19209 26707-26713 NN denotes search
T19208 26703-26706 DT denotes The
T19207 26690-26701 NN denotes experiments
T19206 26683-26689 JJ denotes future
T19205 26680-26682 IN denotes in
T19204 26672-26679 VB denotes studied
T19203 26669-26671 VB denotes be
T19202 26666-26668 TO denotes to
T19201 26660-26665 VB denotes needs
T19200 26649-26659 NN denotes production
T19199 26643-26648 NN denotes IL-17
T19198 26639-26642 IN denotes for
T19197 26633-26638 NN denotes NF-κB
T19196 26629-26632 CC denotes and
T19195 26625-26628 NN denotes p38
T19194 26617-26624 IN denotes between
T19193 26604-26616 NN denotes relationship
T19192 26597-26603 JJ denotes direct
T19191 26593-26596 DT denotes The
T19190 26581-26591 NN denotes activation
T19189 26576-26580 NN denotes PI3K
T19188 26573-26575 IN denotes of
T19187 26561-26572 JJ denotes independent
T19186 26553-26560 NN denotes pathway
T19185 26548-26552 NN denotes MAPK
T19184 26544-26547 NN denotes p38
T19183 26542-26543 DT denotes a
T19182 26538-26541 IN denotes for
T19181 26529-26537 NN denotes evidence
T19180 26525-26528 DT denotes the
T19157 26380-26387 NN denotes results
T19156 26376-26379 PRP-DOLLAR- denotes Our
T19155 26373-26374 -RRB- denotes ]
T19154 26371-26373 CD denotes 33
T19153 26370-26371 -LRB- denotes [
T19152 26362-26369 NN denotes protein
T19151 26344-26361 JJ denotes p300/CREB-binding
T19150 26334-26343 NN denotes acetylase
T19149 26326-26333 NN denotes histone
T19148 26316-26325 VB denotes involving
T19147 26306-26315 NN denotes mechanism
T19146 26304-26305 DT denotes a
T19145 26301-26303 IN denotes by
T19144 26295-26300 NN denotes NF-κB
T19143 26285-26294 VB denotes stimulate
T19142 26281-26284 MD denotes can
T19141 26277-26280 NN denotes p38
T19140 26267-26276 VB denotes activated
T19139 26263-26266 DT denotes the
T19138 26259-26262 CC denotes and
T19137 26257-26258 -COMMA- denotes ,
T19136 26256-26257 -RRB- denotes ]
T19135 26254-26256 CD denotes 32
T19134 26253-26254 -LRB- denotes [
T19133 26249-26252 NN denotes p38
T19132 26246-26248 IN denotes by
T19131 26236-26245 VB denotes activated
T19130 26233-26235 VB denotes is
T19129 26224-26232 NN denotes kinase-β
T19128 26220-26223 NN denotes IκB
T19127 26218-26219 -COMMA- denotes ,
T19126 26210-26218 NN denotes myocytes
T19125 26207-26209 IN denotes In
T19124 26202-26205 NN denotes p38
T19123 26198-26201 CC denotes and
T19122 26192-26197 NN denotes NF-κB
T19121 26184-26191 IN denotes between
T19120 26174-26183 NN denotes crosstalk
T19119 26165-26173 VB denotes supports
T19118 26156-26164 NN denotes evidence
T19117 26153-26155 IN denotes of
T19116 26146-26152 NN denotes series
T19115 26144-26145 DT denotes a
T19114 26139-26143 IN denotes that
T19113 26127-26138 JJ denotes interesting
T19112 26124-26126 VB denotes is
T19111 26121-26123 PRP denotes It
T19110 26110-26119 NN denotes inhibitor
T19109 26105-26109 NN denotes MAPK
T19399 27820-27824 NN denotes PDTC
T19398 27817-27819 IN denotes by
T19397 27808-27816 NN denotes promoter
T19396 27802-27807 NN denotes IL-17
T19108 26101-26104 NN denotes p38
T19107 26099-26100 DT denotes a
T19106 26097-26098 -COMMA- denotes ,
T19105 26089-26097 NN denotes SB203580
T19104 26086-26088 IN denotes of
T19103 26077-26085 NN denotes addition
T19102 26073-26076 DT denotes the
T19101 26070-26072 IN denotes by
T19100 26056-26069 VB denotes downregulated
T19099 26052-26055 VB denotes was
T19098 26041-26051 NN denotes production
T19097 26035-26040 NN denotes IL-17
T19096 26018-26034 JJ denotes anti-CD3-induced
T19095 26013-26017 IN denotes that
T19094 26007-26012 VB denotes found
T19093 26002-26006 RB denotes also
T19092 25999-26001 PRP denotes We
T19091 25986-25997 NN denotes stimulation
T19090 25978-25985 IN denotes without
T19089 25967-25977 NN denotes production
T19088 25961-25966 JJ denotes basal
T19087 25958-25960 IN denotes of
T19086 25951-25957 NN denotes levels
T19085 25940-25950 JJ denotes comparable
T19084 25937-25939 TO denotes to
T19083 25932-25936 NN denotes PDTC
T19082 25922-25931 NN denotes inhibitor
T19081 25916-25921 NN denotes NF-κB
T19080 25912-25915 DT denotes the
T19079 25908-25911 CC denotes and
T19078 25899-25907 NN denotes LY294002
T19077 25889-25898 NN denotes inhibitor
T19076 25884-25888 NN denotes PI3K
T19075 25880-25883 DT denotes the
T19074 25877-25879 IN denotes by
T19073 25868-25876 VB denotes hampered
T19072 25854-25867 RB denotes significantly
T19071 25850-25853 VB denotes was
T19070 25845-25849 NN denotes PBMC
T19069 25842-25844 NN denotes RA
T19068 25839-25841 IN denotes in
T19067 25828-25838 NN denotes production
T19066 25822-25827 NN denotes IL-17
T19065 25805-25821 JJ denotes anti-CD3-induced
T19064 25800-25804 IN denotes that
T19063 25789-25799 VB denotes identified
T19062 25786-25788 PRP denotes We
T19061 25780-25784 NN denotes PBMC
T19060 25777-25779 NN denotes RA
T19059 25774-25776 IN denotes in
T19058 25768-25773 NN denotes IL-17
T19057 25765-25767 IN denotes of
T19056 25755-25764 NN denotes induction
T19055 25751-25754 DT denotes the
T19054 25748-25750 IN denotes in
T19053 25739-25747 VB denotes involved
T19052 25732-25738 RB denotes mainly
T19051 25728-25731 VB denotes was
T19050 25720-25727 NN denotes pathway
T19049 25710-25719 NN denotes signaling
T19048 25704-25709 WDT denotes which
T19047 25695-25703 VB denotes examined
T19046 25685-25694 RB denotes therefore
T19045 25682-25684 PRP denotes we
T19044 25680-25681 -COMMA- denotes ,
T19043 25670-25680 NN denotes inhibitors
T19042 25657-25669 NN denotes transduction
T19041 25650-25656 NN denotes signal
T19040 25644-25649 VB denotes using
T19039 25641-25643 IN denotes By
T19038 25631-25639 NN denotes pathways
T19037 25621-25630 NN denotes signaling
T19036 25613-25620 JJ denotes certain
T19035 25610-25612 IN denotes by
T19034 25600-25609 VB denotes regulated
T19033 25597-25599 VB denotes be
T19032 25593-25596 MD denotes can
T19031 25582-25592 NN denotes production
T19030 25576-25581 NN denotes IL-17
T19029 25572-25575 WRB denotes how
T19028 25569-25571 IN denotes on
T19027 25559-25568 JJ denotes available
T19026 25554-25558 VB denotes been
T19025 25549-25553 VB denotes have
T19024 25544-25548 NN denotes data
T19023 25541-25543 DT denotes no
T19022 25539-25540 -COMMA- denotes ,
T19021 25538-25539 -RRB- denotes ]
T19020 25531-25538 CD denotes 8,30,31
T19019 25530-25531 -LRB- denotes [
T19018 25523-25529 RB denotes widely
T19017 25512-25522 VB denotes documented
T19016 25507-25511 VB denotes been
T19015 25503-25506 VB denotes has
T19014 25497-25502 NN denotes IL-17
T19013 25494-25496 IN denotes by
T19012 25473-25493 NN denotes cytokines/chemokines
T19011 25470-25472 IN denotes of
T19010 25460-25469 NN denotes induction
T19009 25456-25459 DT denotes the
T19008 25452-25455 IN denotes for
T19007 25444-25451 NN denotes pathway
T19006 25434-25443 NN denotes signaling
T19005 25430-25433 DT denotes the
T19004 25421-25429 IN denotes Although
T19003 25415-25419 NN denotes PBMC
T19002 25412-25414 NN denotes RA
T19001 25409-25411 IN denotes in
T19000 25399-25408 NN denotes induction
T18999 25393-25398 NN denotes IL-17
T18998 25383-25392 VB denotes increases
T18997 25378-25382 RB denotes also
T18996 25359-25377 JJ denotes anti-CD3/anti-CD28
T18995 25351-25358 IN denotes through
T18994 25340-25350 NN denotes activation
T18993 25335-25339 NN denotes cell
T18992 25333-25334 NN denotes T
T18991 25331-25332 -COMMA- denotes ,
T18990 25330-25331 -RRB- denotes ]
T18989 25328-25330 CD denotes 25
T18988 25327-25328 -LRB- denotes [
T18987 25315-25326 NN denotes individuals
T18986 25308-25314 JJ denotes normal
T18985 25304-25307 IN denotes for
T18984 25295-25303 VB denotes reported
T18983 25292-25294 IN denotes As
T18982 25282-25290 NN denotes cultures
T18981 25277-25281 NN denotes PBMC
T18980 25274-25276 IN denotes in
T18979 25252-25273 NN denotes monocytes/macrophages
T18978 25249-25251 IN denotes of
T18977 25238-25248 NN denotes activation
T18976 25234-25237 DT denotes the
T18975 25226-25233 IN denotes through
T18974 25220-25225 NN denotes cells
T18973 25218-25219 NN denotes T
T18972 25215-25217 IN denotes on
T18971 25204-25214 RB denotes indirectly
T18970 25196-25203 NN denotes effects
T18969 25190-25195 VB denotes exert
T18968 25184-25189 MD denotes might
T18967 25181-25183 PRP denotes it
T18966 25179-25180 -COMMA- denotes ,
T18965 25169-25179 NN denotes activation
T18964 25164-25168 NN denotes cell
T18963 25162-25163 NN denotes T
T18962 25154-25161 VB denotes induces
T18961 25145-25153 RB denotes directly
T18960 25139-25144 NN denotes MCP-1
T18959 25134-25138 IN denotes that
T18958 25129-25133 NN denotes data
T18957 25126-25128 DT denotes no
T18956 25121-25125 VB denotes were
T18955 25115-25120 EX denotes there
T18954 25106-25114 IN denotes Although
T18953 25103-25104 -RRB- denotes ]
T18952 25101-25103 CD denotes 13
T18951 25100-25101 -LRB- denotes [
T18950 25097-25099 RB denotes so
T18949 25094-25096 VB denotes do
T18948 25090-25093 RB denotes not
T18947 25086-25089 VB denotes did
T18946 25080-25085 NN denotes TNF-α
T18945 25076-25079 CC denotes but
T18944 25074-25075 -COMMA- denotes ,
T18943 25070-25074 NN denotes PBMC
T18942 25067-25069 IN denotes in
T18836 24421-24430 RB denotes therefore
T18835 24418-24420 PRP denotes We
T18834 24415-24416 -RRB- denotes ]
T18833 24410-24415 CD denotes 13,14
T18832 24409-24410 -LRB- denotes [
T18831 24398-24408 NN denotes production
T18830 24392-24397 NN denotes IL-17
T18829 24383-24391 VB denotes regulate
T18828 24380-24382 TO denotes to
T18827 24374-24379 VB denotes known
T18826 24369-24373 VB denotes been
T18825 24364-24368 VB denotes have
T18824 24362-24363 -RRB- denotes )
T18823 24357-24362 NN denotes IL-23
T18822 24353-24356 CC denotes and
T18821 24347-24352 NN denotes IL-15
T18820 24346-24347 -LRB- denotes (
T18819 24336-24345 NN denotes cytokines
T18818 24331-24335 DT denotes some
T18817 24322-24330 IN denotes although
T18816 24320-24321 -COMMA- denotes ,
T18815 24318-24320 NN denotes RA
T18814 24315-24317 IN denotes in
T18813 24304-24314 NN denotes production
T18812 24298-24303 NN denotes IL-17
T18811 24288-24297 VB denotes stimulate
T18810 24283-24287 WDT denotes that
T18809 24276-24282 NN denotes agents
T18808 24272-24275 DT denotes the
T18807 24269-24271 IN denotes on
T18806 24259-24268 JJ denotes available
T18805 24254-24258 NN denotes data
T18804 24250-24253 JJ denotes few
T18803 24246-24249 RB denotes yet
T18802 24243-24245 RB denotes as
T18801 24239-24242 VB denotes are
T18800 24233-24238 EX denotes There
T18799 24230-24231 -RRB- denotes ]
T18798 24222-24230 CD denotes 12,28,29
T18797 24221-24222 -LRB- denotes [
T18796 24215-24220 FW denotes vitro
T18795 24212-24214 FW denotes in
T18794 24209-24211 NN denotes E2
T18793 24195-24208 NN denotes prostaglandin
T18792 24192-24194 IN denotes as
T18791 24187-24191 RB denotes well
T18790 24184-24186 RB denotes as
T18789 24182-24183 CD denotes 6
T18788 24177-24181 NN denotes gene
T19179 26516-26524 VB denotes provided
T19178 26510-26515 WDT denotes which
T19177 26508-26509 -COMMA- denotes ,
T19176 26500-26508 NN denotes LY294002
T19175 26497-26499 IN denotes by
T19174 26487-26496 VB denotes decreased
T19173 26483-26486 VB denotes was
T19172 26474-26482 NN denotes activity
T19171 26466-26473 NN denotes binding
T19170 26460-26465 NN denotes NF-κB
T19169 26452-26459 IN denotes whereas
T19168 26450-26451 -COMMA- denotes ,
T19167 26442-26450 NN denotes LY294002
T19166 26439-26441 IN denotes by
T19165 26430-26438 VB denotes affected
T19164 26426-26429 RB denotes not
T19163 26422-26425 VB denotes was
T19162 26411-26421 NN denotes activation
T19161 26406-26410 NN denotes MAPK
T19160 26402-26405 NN denotes p38
T19159 26397-26401 IN denotes that
T19158 26388-26396 VB denotes revealed
T18787 24159-24176 JJ denotes factor-stimulated
T18786 24150-24158 NN denotes necrosis
T18785 24144-24149 NN denotes tumor
T18784 24140-24143 CC denotes and
T18783 24135-24139 NN denotes IL-8
T18782 24133-24134 -COMMA- denotes ,
T18781 24129-24133 NN denotes IL-6
T18780 24126-24128 IN denotes as
T18779 24121-24125 JJ denotes such
T18778 24111-24120 NN denotes cytokines
T18777 24103-24110 JJ denotes several
T18776 24095-24102 VB denotes secrete
T18775 24092-24094 TO denotes to
T18774 24079-24091 NN denotes synoviocytes
T18773 24068-24078 JJ denotes rheumatoid
T18772 24057-24067 VB denotes stimulates
T18771 24051-24056 NN denotes IL-17
T18770 24049-24050 -COMMA- denotes ,
T18769 24042-24049 NN denotes example
T18768 24038-24041 IN denotes For
T18767 24030-24036 NN denotes joints
T18766 24026-24029 DT denotes the
T18765 24023-24025 IN denotes in
T18764 24017-24022 NN denotes cells
T18763 24011-24016 JJ denotes other
T18762 24002-24010 VB denotes activate
T18761 23997-24001 RB denotes also
T18760 23991-23996 WDT denotes which
T18759 23989-23990 -COMMA- denotes ,
T18758 23979-23989 NN denotes chemokines
T18757 23975-23978 CC denotes and
T18756 23965-23974 NN denotes cytokines
T18755 23949-23964 JJ denotes proinflammatory
T18754 23946-23948 IN denotes of
T18753 23938-23945 NN denotes variety
T18752 23936-23937 DT denotes a
T18751 23928-23935 VB denotes produce
T18750 23922-23927 MD denotes might
T18749 23915-23921 NN denotes joints
T18748 23912-23914 NN denotes RA
T18747 23903-23911 JJ denotes inflamed
T18746 23900-23902 IN denotes in
T18745 23894-23899 NN denotes cells
T18744 23886-23893 IN denotes between
T18743 23874-23885 NN denotes interaction
T18742 23866-23873 JJ denotes complex
T18741 23864-23865 DT denotes A
T18740 23861-23862 -RRB- denotes ]
T18739 23859-23861 CD denotes 27
T18738 23858-23859 -LRB- denotes [
T18737 23852-23857 NN denotes model
T18736 23842-23851 NN denotes arthritis
T18735 23825-23841 JJ denotes collagen-induced
T18734 23823-23824 DT denotes a
T18733 23820-23822 IN denotes in
T18732 23811-23819 NN denotes collagen
T18731 23808-23810 CD denotes II
T18730 23803-23807 NN denotes type
T18729 23791-23802 VB denotes recognizing
T18728 23785-23790 NN denotes cells
T18727 23783-23784 NN denotes T
T18726 23780-23782 IN denotes by
T18725 23770-23779 VB denotes augmented
T18724 23756-23769 RB denotes significantly
T18723 23752-23755 VB denotes was
T18722 23741-23751 NN denotes production
T18721 23735-23740 NN denotes IL-17
T18720 23733-23734 -COMMA- denotes ,
T18719 23725-23733 NN denotes addition
T18718 23722-23724 IN denotes In
T18717 23719-23720 -RRB- denotes ]
T18716 23717-23719 CD denotes 14
T18715 23716-23717 -LRB- denotes [
T18714 23706-23715 NN denotes infection
T18713 23696-23705 JJ denotes pulmonary
T18712 23682-23695 JJ denotes Gram-negative
T18711 23679-23681 IN denotes in
T18710 23669-23678 NN denotes mechanism
T18709 23658-23668 NN denotes triggering
T18708 23652-23657 NN denotes IL-23
T18707 23649-23651 DT denotes an
T18706 23645-23648 IN denotes via
T18705 23639-23644 NN denotes cells
T18704 23637-23638 NN denotes T
T18703 23632-23636 JJ denotes CD8+
T18702 23629-23631 IN denotes by
T18701 23620-23628 VB denotes produced
T18700 23617-23619 VB denotes be
T18699 23612-23616 RB denotes also
T18698 23608-23611 MD denotes can
T18697 23605-23607 PRP denotes it
T18696 23603-23604 -COMMA- denotes ,
T18695 23596-23603 RB denotes However
T18694 23593-23594 -RRB- denotes ]
T18693 23591-23593 CD denotes 26
T18692 23590-23591 -LRB- denotes [
T18691 23580-23589 NN denotes phenotype
T18690 23576-23579 NN denotes Th2
T18689 23572-23575 DT denotes the
T18688 23568-23571 RB denotes not
T18687 23566-23567 -COMMA- denotes ,
T18686 23561-23566 NN denotes cells
T18685 23553-23560 NN denotes Th1/Th0
T18684 23549-23552 IN denotes for
T18683 23538-23548 RB denotes especially
T18682 23536-23537 -COMMA- denotes ,
T18681 23531-23536 NN denotes cells
T18680 23529-23530 NN denotes T
T18679 23524-23528 JJ denotes CD4+
T18678 23514-23523 VB denotes activated
T18677 23511-23513 IN denotes by
T18676 23504-23510 RB denotes mainly
T18675 23495-23503 VB denotes produced
T18674 23492-23494 VB denotes is
T18673 23486-23491 NN denotes IL-17
T18672 23471-23484 NN denotes proliferation
T18671 23462-23470 JJ denotes cellular
T18670 23459-23461 TO denotes to
T18669 23454-23458 IN denotes than
T18668 23447-23453 RB denotes rather
T18667 23438-23446 NN denotes activity
T18666 23429-23437 JJ denotes cellular
T18665 23419-23428 VB denotes increased
T18664 23416-23418 TO denotes to
T18663 23412-23415 JJ denotes due
T18662 23409-23411 VB denotes be
T18661 23403-23408 MD denotes might
T18660 23397-23402 NN denotes IL-17
T18659 23394-23396 IN denotes of
T18658 23381-23393 NN denotes upregulation
T18657 23376-23380 DT denotes this
T18656 23371-23375 IN denotes that
T18655 23369-23370 -COMMA- denotes ,
T18654 23368-23369 -RRB- denotes )
T18653 23363-23368 VB denotes shown
T18652 23359-23362 RB denotes not
T18651 23354-23358 NN denotes data
T18650 23353-23354 -LRB- denotes (
T18649 23347-23352 NN denotes assay
T18648 23333-23346 NN denotes proliferation
T18647 23328-23332 NN denotes cell
T18646 23326-23327 DT denotes a
T18645 23323-23325 IN denotes by
T18644 23321-23322 -COMMA- denotes ,
T18643 23316-23321 VB denotes found
T18642 23313-23315 PRP denotes We
T18641 23305-23311 NN denotes manner
T18640 23290-23304 JJ denotes dose-dependent
T18639 23288-23289 DT denotes a
T18638 23285-23287 IN denotes in
T18637 23280-23284 NN denotes PBMC
T18636 23277-23279 NN denotes RA
T18635 23272-23276 IN denotes from
T18634 23261-23271 NN denotes production
T18633 23255-23260 NN denotes IL-17
T18632 23245-23254 VB denotes increased
T18631 23243-23244 -COMMA- denotes ,
T18630 23235-23243 NN denotes receptor
T18629 23230-23234 NN denotes cell
T18628 23228-23229 NN denotes T
T18627 23224-23227 DT denotes the
T18626 23216-23223 IN denotes through
T18625 23206-23215 NN denotes signaling
T18624 23202-23205 IN denotes for
T18623 23183-23201 JJ denotes anti-CD3/anti-CD28
T18622 23180-23182 IN denotes as
T18621 23175-23179 RB denotes well
T18576 22918-22925 RB denotes However
T18575 22915-22916 -RRB- denotes ]
T18574 22913-22915 CD denotes 15
T18573 22912-22913 -LRB- denotes [
T18572 22906-22911 NN denotes fluid
T18571 22897-22905 JJ denotes synovial
T18570 22894-22896 NN denotes OA
T18569 22891-22893 IN denotes in
T18568 22886-22890 IN denotes than
T18567 22880-22885 NN denotes fluid
T18566 22871-22879 JJ denotes synovial
T18565 22868-22870 NN denotes RA
T18564 22865-22867 IN denotes in
T18563 22858-22864 JJ denotes higher
T18562 22855-22857 VB denotes be
T18561 22852-22854 TO denotes to
T18560 22846-22851 VB denotes found
T18559 22841-22845 VB denotes were
T18558 22835-22840 NN denotes IL-17
T18557 22832-22834 IN denotes of
T18556 22825-22831 NN denotes Levels
T18555 22819-22823 VB denotes used
T18554 22816-22818 PRP denotes it
T18553 22808-22815 NN denotes pathway
T18552 22798-22807 NN denotes signaling
T18551 22792-22797 WDT denotes which
T18550 22788-22791 CC denotes and
T18549 22786-22787 -COMMA- denotes ,
T18548 22782-22786 NN denotes PBMC
T18547 22779-22781 NN denotes RA
T18546 22776-22778 IN denotes in
T18545 22766-22775 VB denotes regulated
T18544 22763-22765 VB denotes is
T18543 22752-22762 NN denotes production
T18542 22746-22751 NN denotes IL-17
T18541 22742-22745 WRB denotes how
T18540 22733-22741 VB denotes evaluate
T18539 22730-22732 TO denotes to
T18538 22724-22729 VB denotes tried
T18537 22721-22723 PRP denotes we
T18536 22719-22720 -COMMA- denotes ,
T18535 22712-22719 NN denotes studies
T18534 22708-22711 PRP-DOLLAR- denotes our
T18533 22705-22707 IN denotes In
T18532 22693-22703 NN denotes properties
T18531 22677-22692 JJ denotes proinflammatory
T18530 22672-22676 IN denotes with
T18529 22663-22671 NN denotes cytokine
T18528 22650-22662 JJ denotes cell-derived
T18941 25056-25066 NN denotes production
T18940 25050-25055 NN denotes IL-17
T18939 25044-25049 FW denotes vitro
T18938 25041-25043 FW denotes in
T18937 25031-25040 VB denotes triggered
T18936 25025-25030 NN denotes IL-15
T18935 25020-25024 IN denotes that
T18934 25013-25019 NN denotes report
T18933 25006-25012 JJ denotes recent
T18932 25004-25005 DT denotes a
T18931 24999-25003 IN denotes with
T18930 24988-24998 JJ denotes consistent
T18929 24983-24987 VB denotes were
T18928 24978-24982 NN denotes data
T18927 24974-24977 PRP-DOLLAR- denotes Our
T18926 24962-24972 NN denotes production
T18925 24956-24961 NN denotes IL-17
T18924 24949-24955 VB denotes affect
T18923 24945-24948 RB denotes not
T18922 24941-24944 VB denotes did
T18921 24939-24940 -COMMA- denotes ,
T18920 24933-24939 NN denotes joints
T18919 24930-24932 NN denotes RA
T18918 24927-24929 IN denotes in
T18917 24917-24926 VB denotes increased
T18916 24914-24916 VB denotes be
T18915 24911-24913 TO denotes to
T18914 24907-24910 CC denotes and
T18913 24896-24906 NN denotes properties
T18912 24880-24895 JJ denotes proinflammatory
T18911 24875-24879 VB denotes have
T18910 24872-24874 TO denotes to
T18909 24866-24871 VB denotes known
T18908 24862-24865 VB denotes are
T18907 24856-24861 WDT denotes which
T18906 24854-24855 -COMMA- denotes ,
T18905 24849-24854 NN denotes TNF-α
T18904 24845-24848 CC denotes and
T18903 24840-24844 NN denotes IL-1
T18902 24838-24839 -COMMA- denotes ,
T18901 24830-24838 NN denotes contrast
T18900 24827-24829 IN denotes In
T18899 24817-24825 RB denotes markedly
T18898 24812-24816 RB denotes more
T18897 24801-24811 NN denotes production
T18896 24795-24800 NN denotes IL-17
T18895 24785-24794 VB denotes augmented
T18894 24776-24784 NN denotes ligation
T18893 24772-24775 NN denotes TCR
T18892 24769-24771 TO denotes to
T18891 24763-24768 NN denotes MCP-1
T18890 24760-24762 CC denotes or
T18889 24754-24759 NN denotes IL-15
T18888 24747-24753 VB denotes Adding
T18887 24741-24745 NN denotes PBMC
T18886 24738-24740 NN denotes RA
T18885 24735-24737 IN denotes in
T18884 24729-24734 NN denotes IL-17
T18883 24726-24728 IN denotes of
T18882 24715-24725 NN denotes production
T18881 24711-24714 DT denotes the
T18880 24701-24710 VB denotes increased
T18879 24687-24700 RB denotes significantly
T18878 24678-24686 NN denotes ligation
T18877 24674-24677 NN denotes TCR
T18876 24671-24673 IN denotes as
T18875 24666-24670 RB denotes well
T18874 24663-24665 RB denotes as
T18873 24657-24662 NN denotes MCP-1
T18872 24653-24656 CC denotes and
T18871 24647-24652 NN denotes IL-15
T18870 24642-24646 IN denotes that
T18869 24629-24641 VB denotes demonstrated
T18868 24621-24628 NN denotes studies
T18867 24617-24620 PRP-DOLLAR- denotes Our
T18866 24597-24615 JJ denotes anti-CD3/anti-CD28
T18865 24591-24596 VB denotes using
T18864 24582-24590 NN denotes ligation
T18863 24580-24581 -RRB- denotes )
T18862 24577-24580 NN denotes TCR
T18861 24576-24577 -LRB- denotes (
T18860 24567-24575 NN denotes receptor
T18859 24562-24566 NN denotes cell
T18858 24560-24561 NN denotes T
T18857 24557-24559 IN denotes as
T18856 24552-24556 RB denotes well
T18855 24549-24551 RB denotes as
T18854 24540-24548 NN denotes mitogens
T18853 24536-24539 CC denotes and
T18852 24515-24535 NN denotes cytokines/chemokines
T18851 24512-24514 IN denotes of
T18850 24504-24511 NN denotes variety
T18849 24502-24503 DT denotes a
T18848 24499-24501 TO denotes to
T18847 24488-24498 VB denotes responding
T18846 24483-24487 NN denotes PBMC
T18845 24480-24482 NN denotes RA
T18844 24477-24479 IN denotes in
T18843 24471-24476 NN denotes IL-17
T18842 24468-24470 IN denotes of
T18841 24457-24467 NN denotes production
T18840 24451-24456 FW denotes vitro
T18839 24448-24450 FW denotes in
T18838 24444-24447 DT denotes the
T18837 24431-24443 VB denotes investigated
T18527 22648-22649 NN denotes T
T18526 22646-22647 DT denotes a
T18525 22643-22645 IN denotes as
T18524 22633-22642 VB denotes described
T18523 22628-22632 VB denotes been
T18522 22624-22627 VB denotes has
T18521 22621-22623 PRP denotes it
T18520 22613-22620 IN denotes because
T18519 22603-22612 VB denotes appealing
T18518 22600-22602 VB denotes is
T18517 22594-22599 NN denotes IL-17
T18516 22592-22593 -COMMA- denotes ,
T18515 22585-22592 NN denotes respect
T18514 22580-22584 DT denotes this
T18513 22577-22579 IN denotes In
T18512 22565-22575 NN denotes importance
T18511 22561-22564 PRP-DOLLAR- denotes its
T18510 22553-22560 VB denotes limited
T18509 22549-22552 VB denotes has
T18508 22539-22548 NN denotes cytokines
T18507 22526-22538 JJ denotes cell-derived
T18506 22524-22525 NN denotes T
T18505 22521-22523 IN denotes of
T18504 22516-22520 NN denotes lack
T18503 22512-22515 DT denotes the
T18502 22510-22511 -COMMA- denotes ,
T18501 22498-22510 NN denotes inflammation
T18500 22489-22497 JJ denotes synovial
T18499 22478-22488 JJ denotes rheumatoid
T18498 22475-22477 IN denotes of
T18497 22462-22474 NN denotes augmentation
T18496 22458-22461 DT denotes the
T18495 22455-22457 IN denotes in
T18494 22450-22454 NN denotes role
T18493 22448-22449 DT denotes a
T18492 22443-22447 VB denotes have
T18491 22439-22442 MD denotes may
T18490 22433-22438 NN denotes cells
T18489 22431-22432 NN denotes T
T18488 22422-22430 IN denotes Although
T18487 22419-22420 -RRB- denotes ]
T18486 22417-22419 CD denotes 24
T18485 22416-22417 -LRB- denotes [
T18484 22407-22415 NN denotes synovium
T18483 22404-22406 NN denotes RA
T18482 22401-22403 IN denotes in
T18481 22394-22400 VB denotes detect
T18480 22391-22393 TO denotes to
T18479 22381-22390 JJ denotes difficult
T18478 22374-22380 VB denotes proved
T18477 22368-22373 RB denotes often
T18476 22363-22367 VB denotes have
T18475 22361-22362 -COMMA- denotes ,
T18474 22349-22361 NN denotes interferon-γ
T18473 22345-22348 CC denotes and
T18472 22340-22344 NN denotes IL-4
T18471 22329-22339 RB denotes especially
T18470 22327-22328 -COMMA- denotes ,
T18469 22318-22327 NN denotes cytokines
T18468 22305-22317 JJ denotes cell-derived
T18467 22303-22304 NN denotes T
T18466 22299-22302 DT denotes the
T18465 22291-22298 IN denotes whereas
T18464 22289-22290 -COMMA- denotes ,
T18463 22281-22289 NN denotes synovium
T18462 22270-22280 JJ denotes rheumatoid
T18461 22267-22269 IN denotes in
T18460 22258-22266 JJ denotes abundant
T18459 22254-22257 VB denotes are
T18458 22248-22253 NN denotes TNF-α
T18457 22244-22247 CC denotes and
T18456 22239-22243 NN denotes IL-1
T18455 22236-22238 IN denotes as
T18454 22231-22235 JJ denotes such
T18453 22221-22230 NN denotes cytokines
T18452 22205-22220 JJ denotes Proinflammatory
T18451 22202-22203 -RRB- denotes ]
T18450 22200-22202 CD denotes 23
T18449 22199-22200 -LRB- denotes [
T18448 22193-22198 NN denotes cells
T18447 22181-22192 JJ denotes mononuclear
T18446 22178-22180 IN denotes by
T18445 22165-22177 NN denotes infiltration
T18444 22157-22164 JJ denotes intense
T18443 22154-22156 DT denotes an
T18442 22150-22153 CC denotes and
T18441 22144-22149 NN denotes cells
T18440 22137-22143 JJ denotes lining
T18439 22128-22136 JJ denotes synovial
T18438 22125-22127 IN denotes of
T18437 22113-22124 NN denotes hyperplasia
T18436 22110-22112 IN denotes by
T18435 22096-22109 VB denotes characterized
T18434 22093-22095 VB denotes is
T18433 22090-22092 NN denotes RA
T18432 22087-22088 -RRB- denotes ]
T18431 22083-22087 CD denotes 5,22
T18430 22082-22083 -LRB- denotes [
T18429 22071-22081 NN denotes properties
T18428 22055-22070 JJ denotes proinflammatory
T18427 22050-22054 IN denotes with
T18426 22042-22049 NN denotes product
T18425 22037-22041 NN denotes cell
T18424 22035-22036 NN denotes T
T18423 22033-22034 DT denotes a
T18422 22030-22032 IN denotes as
T18421 22020-22029 VB denotes described
T18420 22014-22019 RB denotes first
T18419 22010-22013 VB denotes was
T18418 22004-22009 NN denotes IL-17
T18620 23172-23174 RB denotes as
T18619 23170-23171 -COMMA- denotes ,
T18618 23162-23170 NN denotes mitogens
T18617 23159-23161 IN denotes as
T18616 23155-23158 NN denotes PHA
T18615 23153-23154 -COMMA- denotes ,
T18614 23142-23153 NN denotes experiments
T18613 23138-23141 PRP-DOLLAR- denotes our
T18612 23135-23137 IN denotes In
T18611 23132-23133 -RRB- denotes ]
T18610 23130-23132 CD denotes 25
T18609 23129-23130 -LRB- denotes [
T18608 23117-23128 NN denotes individuals
T18607 23109-23116 JJ denotes healthy
T18606 23106-23108 IN denotes in
T18605 23094-23105 NN denotes stimulation
T18604 23075-23093 JJ denotes anti-CD3/anti-CD28
T18603 23072-23074 IN denotes by
T18602 23063-23071 VB denotes achieved
T18601 23060-23062 VB denotes be
T18600 23056-23059 MD denotes can
T18599 23045-23055 NN denotes production
T18598 23039-23044 NN denotes IL-17
T18597 23036-23038 IN denotes of
T18596 23030-23035 NN denotes level
T18595 23022-23029 JJ denotes highest
T18594 23018-23021 DT denotes the
T18593 23009-23017 IN denotes although
T18592 23007-23008 -COMMA- denotes ,
T18591 23005-23007 NN denotes RA
T18590 23002-23004 IN denotes in
T18589 22991-23001 NN denotes production
T18588 22985-22990 NN denotes IL-17
T18587 22975-22984 VB denotes stimulate
T18586 22970-22974 WDT denotes that
T18585 22963-22969 NN denotes agents
T18584 22959-22962 DT denotes the
T18583 22956-22958 IN denotes on
T18582 22946-22955 JJ denotes available
T18581 22941-22945 NN denotes data
T18580 22937-22940 JJ denotes few
T18579 22933-22936 VB denotes are
T18578 22927-22932 EX denotes there
T18577 22925-22926 -COMMA- denotes ,
T16026 21297-21303 NN denotes degree
T16025 21293-21296 DT denotes the
T16024 21289-21292 CC denotes but
T16023 21287-21288 -COMMA- denotes ,
T16022 21279-21287 VB denotes observed
T16021 21275-21278 VB denotes was
T16020 21267-21274 NN denotes pattern
T16019 21262-21266 JJ denotes same
T16018 21258-21261 DT denotes the
T16017 21253-21257 NN denotes PBMC
T16016 21246-21252 JJ denotes normal
T16015 21243-21245 IN denotes In
T16014 21240-21241 -RRB- denotes )
T16013 21239-21240 CD denotes 5
T16012 21234-21238 NN denotes lane
T16011 21233-21234 -LRB- denotes (
T16010 21227-21232 NN denotes c-Rel
T16009 21224-21226 IN denotes in
T16008 21220-21223 RB denotes not
T16007 21218-21219 -RRB- denotes )
T16006 21217-21218 CD denotes 4
T16005 21213-21216 CC denotes and
T16004 21211-21212 CD denotes 3
T16003 21205-21210 NN denotes lanes
T16002 21204-21205 -LRB- denotes (
T16001 21200-21203 NN denotes p50
T16000 21196-21199 CC denotes and
T15999 21192-21195 NN denotes p65
T15998 21189-21191 IN denotes in
T15997 21183-21188 NN denotes bands
T15996 21175-21182 VB denotes shifted
T15995 21162-21174 VB denotes demonstrated
T15994 21156-21161 NN denotes assay
T15993 21145-21155 NN denotes supershift
T15992 21143-21144 DT denotes A
T15991 21140-21141 -RRB- denotes )
T15990 21139-21140 CD denotes 1
T15989 21134-21138 NN denotes lane
T15988 21133-21134 -LRB- denotes (
T15987 21124-21132 NN denotes controls
T15986 21121-21123 IN denotes of
T15985 21116-21120 DT denotes that
T15984 21111-21115 IN denotes with
T15983 21100-21110 NN denotes comparison
T15982 21097-21099 IN denotes in
T15981 21087-21096 NN denotes promoters
T15980 21081-21086 NN denotes IL-17
T15979 21078-21080 TO denotes to
T15978 21072-21077 NN denotes NF-κB
T15977 21069-21071 IN denotes of
T15976 21061-21068 NN denotes binding
T15975 21051-21060 VB denotes increased
T15974 21038-21050 VB denotes demonstrated
T15973 21036-21037 -RRB- denotes )
T15972 21035-21036 CD denotes 2
T15971 21030-21034 NN denotes lane
T15970 21029-21030 -LRB- denotes (
T15969 21019-21028 NN denotes anti-CD28
T15968 21014-21018 CC denotes plus
T15967 21005-21013 JJ denotes anti-CD3
T15966 21000-21004 IN denotes with
T15965 20989-20999 VB denotes stimulated
T15964 20984-20988 NN denotes PBMC
T15963 20981-20983 NN denotes RA
T15962 20976-20980 IN denotes from
T15961 20967-20975 NN denotes extracts
T15960 20959-20966 JJ denotes nuclear
T15959 20957-20958 -COMMA- denotes ,
T15958 20955-20957 NNP denotes 7a
T15957 20950-20954 NNP denotes Fig.
T15956 20947-20949 IN denotes in
T15955 20941-20946 VB denotes shown
T15954 20938-20940 IN denotes As
T15953 20931-20936 NN denotes IL-17
T15952 20928-20930 IN denotes of
T15951 20918-20927 NN denotes promoters
T15950 20914-20917 DT denotes the
T15949 20911-20913 IN denotes in
T15948 20905-20910 NN denotes sites
T15947 20893-20904 NN denotes recognition
T15946 20887-20892 NN denotes NF-κB
T15945 20884-20886 IN denotes of
T15944 20882-20883 -RRB- denotes )
T15943 20878-20882 NN denotes EMSA
T15942 20877-20878 -LRB- denotes (
T15941 20871-20876 NN denotes assay
T15940 20856-20870 NN denotes mobility-shift
T15939 20840-20855 JJ denotes electrophoretic
T15938 20837-20839 DT denotes an
T15937 20827-20836 VB denotes performed
T15936 20824-20826 PRP denotes we
T15935 20822-20823 -COMMA- denotes ,
T15934 20812-20822 NN denotes expression
T15933 20806-20811 NN denotes IL-17
T15932 20797-20805 VB denotes inducing
T15931 20793-20796 IN denotes for
T15930 20781-20792 JJ denotes responsible
T15929 20777-20780 CC denotes and
T15928 20775-20776 -COMMA- denotes ,
T15927 20770-20775 NN denotes IL-15
T15926 20766-20769 CC denotes and
T15925 20762-20765 NN denotes PHA
T15924 20760-20761 -COMMA- denotes ,
T15923 20759-20760 NN denotes A
T15922 20746-20758 NN denotes concanavalin
T15921 20744-20745 -COMMA- denotes ,
T15920 20735-20744 NN denotes anti-CD28
T15919 20730-20734 CC denotes plus
T15918 20721-20729 JJ denotes anti-CD3
T15917 20718-20720 IN denotes by
T15916 20708-20717 VB denotes activated
T15915 20700-20707 NN denotes pathway
T15914 20690-20699 NN denotes signaling
T15913 20676-20689 JJ denotes intracellular
T15912 20672-20675 DT denotes the
T15911 20664-20671 RB denotes further
T15910 20652-20663 VB denotes investigate
T15909 20649-20651 TO denotes To
T15908 20642-20648 NN denotes region
T15907 20633-20641 NN denotes promoter
T15906 20627-20632 NN denotes IL-17
T15905 20623-20626 DT denotes the
T15904 20620-20622 IN denotes in
T15903 20612-20619 NN denotes pathway
T15902 20610-20611 -RRB- denotes )
T15901 20606-20610 NN denotes AP-1
T15900 20605-20606 -LRB- denotes (
T15899 20595-20604 NN denotes protein-1
T15898 20585-20594 NN denotes activator
T15897 20581-20584 CC denotes and
T15896 20575-20580 NN denotes NF-κB
T15895 20571-20574 DT denotes the
T15894 20568-20570 IN denotes of
T15893 20557-20567 NN denotes Activation
T16086 21634-21641 NN denotes Western
T16085 21631-21632 -RRB- denotes )
T16147 21988-21990 NN denotes RA
T16146 21983-21987 IN denotes with
T16145 21974-21982 NN denotes patients
T16144 21969-21973 IN denotes from
T16143 21964-21968 NN denotes PBMC
T16142 21954-21963 VB denotes activated
T16141 21951-21953 IN denotes by
T16140 21940-21950 NN denotes production
T16139 21934-21939 NN denotes IL-17
T16138 21931-21933 IN denotes in
T16137 21923-21930 NN denotes pathway
T16136 21913-21922 NN denotes signaling
T16135 21899-21912 JJ denotes intracellular
T16134 21894-21898 JJ denotes main
T16133 21890-21893 DT denotes the
T16132 21887-21889 VB denotes is
T16131 21881-21886 NN denotes NF-κB
T16130 21876-21880 IN denotes that
T16129 21862-21875 VB denotes demonstrating
T16128 21860-21861 -COMMA- denotes ,
T16127 21859-21860 -RRB- denotes )
T16126 21854-21859 VB denotes shown
T16125 21850-21853 RB denotes not
T16124 21845-21849 NN denotes data
T16123 21844-21845 -LRB- denotes (
T16122 21834-21843 JJ denotes anti-CD28
T16121 21829-21833 CC denotes plus
T16120 21820-21828 JJ denotes anti-CD3
T16119 21815-21819 IN denotes with
T16118 21803-21814 NN denotes stimulation
T16117 21800-21802 IN denotes by
T16116 21790-21799 VB denotes activated
T16115 21786-21789 RB denotes not
T16114 21782-21785 VB denotes was
T16113 21774-21781 NN denotes pathway
T16112 21769-21773 NN denotes AP-1
T16111 21765-21768 DT denotes the
T16110 21763-21764 -COMMA- denotes ,
T16109 21755-21763 NN denotes contrast
T16108 21752-21754 IN denotes In
T16107 21749-21750 -RRB- denotes )
T16106 21747-21749 NN denotes 7c
T16105 21742-21746 NN denotes Fig.
T16104 21741-21742 -LRB- denotes (
T16103 21736-21740 NN denotes time
T16102 21731-21735 JJ denotes same
T16101 21727-21730 DT denotes the
T16100 21724-21726 IN denotes at
T16099 21719-21723 NN denotes PDTC
T16098 21715-21718 CC denotes and
T16097 21706-21714 NN denotes LY294002
T16096 21703-21705 IN denotes by
T16095 21697-21702 NN denotes IκB-α
T16094 21694-21696 IN denotes of
T16093 21682-21693 NN denotes degradation
T16092 21679-21681 IN denotes of
T16091 21668-21678 NN denotes inhibition
T16090 21661-21667 VB denotes showed
T16089 21655-21660 NN denotes IκB-α
T16088 21651-21654 IN denotes for
T16087 21642-21650 NN denotes blotting
T16084 21629-21631 NN denotes 7c
T16083 21624-21628 NN denotes Fig.
T16082 21623-21624 -LRB- denotes (
T16081 21614-21622 NN denotes promoter
T16080 21608-21613 NN denotes IL-17
T16079 21604-21607 DT denotes the
T16078 21601-21603 IN denotes in
T16077 21592-21600 NN denotes activity
T16076 21580-21591 JJ denotes DNA-binding
T16075 21574-21579 NN denotes NF-κB
T16074 21568-21573 VB denotes block
T16073 21561-21567 NN denotes agents
T16072 21556-21560 DT denotes Both
T16071 21550-21554 NN denotes PDTC
T16070 21546-21549 CC denotes and
T16069 21537-21545 NN denotes LY294002
T16068 21532-21536 CC denotes both
T16067 21527-21531 IN denotes with
T16066 21517-21526 NN denotes treatment
T16065 21511-21516 IN denotes after
T16064 21502-21510 NN denotes activity
T16063 21494-21501 NN denotes binding
T16062 21488-21493 NN denotes NF-κB
T16061 21484-21487 DT denotes the
T16060 21474-21483 VB denotes determine
T16059 21471-21473 TO denotes to
T16058 21466-21470 NN denotes EMSA
T16057 21456-21465 VB denotes performed
T16056 21453-21455 PRP denotes we
T16055 21451-21452 -COMMA- denotes ,
T16054 21446-21451 NN denotes NF-κB
T16053 21442-21445 CC denotes and
T16052 21433-21441 NN denotes activity
T16051 21428-21432 NN denotes PI3K
T16050 21420-21427 IN denotes between
T16049 21415-21419 NN denotes link
T16048 21411-21414 DT denotes the
T16047 21403-21410 VB denotes confirm
T16046 21400-21402 TO denotes To
T16045 21397-21398 -RRB- denotes )
T16044 21395-21397 NN denotes 7b
T16043 21390-21394 NN denotes Fig.
T16042 21389-21390 -LRB- denotes (
T16041 21384-21388 NN denotes PBMC
T16040 21381-21383 NN denotes RA
T16039 21378-21380 IN denotes in
T16038 21373-21377 DT denotes that
T16037 21368-21372 IN denotes than
T16036 21360-21367 JJ denotes intense
T16035 21355-21359 RB denotes less
T16034 21351-21354 VB denotes was
T16033 21341-21350 NN denotes anti-CD28
T16032 21336-21340 CC denotes plus
T16031 21327-21335 NN denotes anti-CD3
T16030 21324-21326 IN denotes by
T16029 21313-21323 NN denotes activation
T16028 21307-21312 NN denotes NF-κB
T16027 21304-21306 IN denotes of
T15069 20236-20243 VB denotes lasting
T15068 20234-20235 -COMMA- denotes ,
T15067 20231-20234 NN denotes min
T15066 20228-20230 CD denotes 60
T15065 20225-20227 IN denotes at
T15064 20220-20224 NN denotes peak
T15063 20218-20219 DT denotes a
T15062 20210-20217 VB denotes reached
T15061 20208-20209 -RRB- denotes )
T15060 20207-20208 CD denotes 3
T15059 20202-20206 NN denotes lane
T15058 20201-20202 -LRB- denotes (
T15057 20192-20200 NN denotes LY294002
T15056 20189-20191 IN denotes by
T15055 20178-20188 NN denotes inhibition
T15053 20168-20174 NN denotes effect
T15052 20164-20167 DT denotes the
T15051 20160-20163 CC denotes and
T15050 20158-20159 -COMMA- denotes ,
T15049 20157-20158 -RRB- denotes )
T15048 20156-20157 CD denotes 2
T15047 20151-20155 NN denotes lane
T15046 20150-20151 -LRB- denotes (
T15045 20140-20149 VB denotes increased
T15044 20136-20139 NN denotes Akt
T15043 20121-20135 VB denotes phosphorylated
T15042 20119-20120 -COMMA- denotes ,
T15041 20109-20119 NN denotes incubation
T15040 20106-20108 IN denotes of
T15039 20102-20105 NN denotes min
T15038 20099-20101 CD denotes 30
T15037 20093-20098 IN denotes after
T15036 20091-20092 -COMMA- denotes ,
T15035 20084-20091 RB denotes However
T15034 20074-20082 VB denotes observed
T15033 20070-20073 VB denotes was
T15032 20066-20069 NN denotes Akt
T15031 20051-20065 VB denotes phosphorylated
T15030 20048-20050 IN denotes of
T15029 20040-20047 NN denotes amounts
T15028 20036-20039 DT denotes the
T15027 20033-20035 IN denotes in
T15026 20022-20032 NN denotes difference
T15025 20019-20021 DT denotes no
T15024 20017-20018 -COMMA- denotes ,
T15023 20016-20017 -RRB- denotes )
T15022 20014-20016 NN denotes μM
T15021 20011-20013 CD denotes 20
T15020 20010-20011 -LRB- denotes (
T15019 20001-20009 NN denotes LY294002
T15018 19998-20000 CC denotes or
T15017 19996-19997 -RRB- denotes )
T15016 19991-19996 NN denotes μg/ml
T15015 19988-19990 CD denotes 10
T15014 19987-19988 -LRB- denotes (
T15013 19978-19986 NN denotes anti-CD3
T15012 19973-19977 IN denotes with
T15011 19962-19972 NN denotes incubation
T15010 19959-19961 IN denotes of
T15009 19955-19958 NN denotes min
T15008 19952-19954 CD denotes 10
T15007 19949-19951 IN denotes at
T15006 19947-19948 -COMMA- denotes ,
T15005 19946-19947 CD denotes 6
T15004 19941-19945 NNP denotes Fig.
T15003 19938-19940 IN denotes in
T15002 19932-19937 VB denotes shown
T15001 19929-19931 IN denotes As
T15000 19919-19927 NN denotes blotting
T14999 19911-19918 JJ denotes western
T14998 19908-19910 IN denotes by
T14997 19904-19907 NN denotes Akt
T14996 19901-19903 IN denotes of
T14995 19890-19900 NN denotes activation
T14994 19886-19889 DT denotes the
T14993 19876-19885 VB denotes evaluated
T14992 19873-19875 PRP denotes we
T14991 19871-19872 -COMMA- denotes ,
T14990 19864-19871 NN denotes pathway
T14989 19859-19863 NN denotes PI3K
T14988 19855-19858 DT denotes the
T14987 19852-19854 IN denotes of
T14986 19842-19851 NN denotes molecules
T14985 19833-19841 NN denotes effector
T14984 19822-19832 JJ denotes downstream
T14983 19812-19821 VB denotes determine
T14982 19809-19811 TO denotes To
T14981 19800-19808 JJ denotes anti-CD3
T14980 19797-19799 IN denotes by
T14979 19786-19796 NN denotes production
T14978 19780-19785 NN denotes IL-17
T14977 19777-19779 IN denotes on
T14976 19769-19776 NN denotes pathway
T14975 19756-19768 NN denotes transduction
T14974 19749-19755 NN denotes signal
T14973 19740-19748 NN denotes PI3K/Akt
T14972 19737-19739 IN denotes of
T14971 19726-19736 NN denotes Activation
T15122 20553-20554 -RRB- denotes )
T15121 20548-20553 VB denotes shown
T15120 20544-20547 RB denotes not
T15119 20539-20543 NN denotes data
T15118 20538-20539 -LRB- denotes (
T15117 20529-20537 NN denotes LY294002
T15116 20526-20528 IN denotes by
T15115 20523-20525 IN denotes as
T15114 20518-20522 RB denotes well
T15113 20515-20517 RB denotes as
T15112 20510-20514 NN denotes PDTC
T15111 20506-20509 CC denotes and
T15110 20495-20505 NN denotes wortmannin
T15109 20492-20494 IN denotes by
T15108 20481-20491 NN denotes inhibition
T15107 20478-20480 DT denotes an
T15106 20474-20477 VB denotes was
T15105 20468-20473 WDT denotes which
T15104 20466-20467 -COMMA- denotes ,
T15103 20458-20466 NN denotes anti-CD3
T15102 20453-20457 IN denotes with
T15101 20447-20452 VB denotes shown
T15100 20444-20446 IN denotes as
T15099 20440-20443 NN denotes Akt
T15098 20425-20439 VB denotes phosphorylated
T15097 20422-20424 IN denotes on
T15096 20415-20421 NN denotes effect
T15095 20410-20414 JJ denotes same
T15094 20406-20409 DT denotes the
T15093 20393-20405 VB denotes demonstrated
T15092 20388-20392 RB denotes also
T15091 20382-20387 NN denotes IL-15
T15090 20378-20381 CC denotes and
T15089 20376-20377 NN denotes A
T15088 20363-20375 NN denotes concanavalin
T15087 20361-20362 -COMMA- denotes ,
T15086 20358-20361 NN denotes PHA
T15085 20352-20356 NN denotes time
T15084 20341-20351 NN denotes incubation
T15083 20338-20340 IN denotes of
T15082 20327-20337 RB denotes regardless
T15081 20317-20326 JJ denotes unchanged
T15080 20308-20316 VB denotes remained
T15079 20300-20307 NN denotes β-actin
T15078 20296-20299 CC denotes and
T15077 20292-20295 NN denotes Akt
T15076 20273-20291 JJ denotes non-phosphorylated
T15075 20271-20272 -COMMA- denotes ,
T15074 20263-20271 NN denotes contrast
T15073 20260-20262 IN denotes In
T15072 20255-20258 NN denotes min
T15071 20247-20254 CD denotes 120–240
T15070 20244-20246 TO denotes to
T14564 19722-19723 -RRB- denotes )
T14563 19721-19722 CD denotes 5
T14562 19716-19720 NNP denotes Fig.
T14561 19715-19716 -LRB- denotes (
T14560 19710-19714 NN denotes PDTC
T14559 19700-19709 NN denotes inhibitor
T14558 19694-19699 NN denotes NF-κB
T14557 19690-19693 DT denotes the
T14556 19687-19689 IN denotes by
T14555 19683-19686 CC denotes and
T14554 19674-19682 NN denotes LY294002
T14553 19664-19673 NN denotes inhibitor
T14552 19659-19663 NN denotes PI3K
T14551 19655-19658 DT denotes the
T14550 19652-19654 IN denotes by
T14549 19642-19651 VB denotes inhibited
T14548 19638-19641 VB denotes was
T14547 19633-19637 DT denotes this
T14546 19631-19632 -COLON- denotes ;
T14545 19623-19631 NN denotes anti-CD3
T14544 19618-19622 IN denotes with
T14543 19606-19617 NN denotes stimulation
T14542 19600-19605 IN denotes after
T14541 19588-19599 NN denotes transcripts
T14540 19583-19587 NN denotes mRNA
T14539 19577-19582 NN denotes IL-17
T14538 19574-19576 IN denotes in
T14537 19565-19573 NN denotes increase
T14536 19550-19564 JJ denotes dose-dependent
T14535 19548-19549 DT denotes a
T14534 19539-19547 VB denotes observed
T14533 19536-19538 PRP denotes We
T14532 19525-19534 VB denotes performed
T14531 19521-19524 VB denotes was
T14530 19512-19520 NN denotes reaction
T14529 19506-19511 NN denotes chain
T14528 19481-19505 NN denotes transcription–polymerase
T14527 19473-19480 JJ denotes reverse
T14526 19455-19472 JJ denotes semi-quantatitive
T14525 19453-19454 -COMMA- denotes ,
T14524 19448-19453 NN denotes level
T14523 19432-19447 JJ denotes transcriptional
T14522 19430-19431 DT denotes a
T14521 19427-19429 IN denotes at
T14520 19417-19426 VB denotes regulated
T14519 19414-19416 VB denotes be
T14518 19408-19413 MD denotes could
T14517 19397-19407 NN denotes production
T14516 19391-19396 NN denotes IL-17
T14515 19382-19390 VB denotes enhanced
T14514 19374-19381 IN denotes whether
T14513 19370-19373 VB denotes see
T14512 19367-19369 TO denotes To
T14511 19362-19366 NN denotes PBMC
T14510 19359-19361 NN denotes RA
T14509 19356-19358 IN denotes in
T14508 19345-19355 NN denotes expression
T14507 19340-19344 NN denotes mRNA
T14506 19334-19339 NN denotes IL-17
T13824 19197-19204 NN denotes pattern
T13844 19330-19331 -RRB- denotes )
T13843 19328-19330 NN denotes 4b
T13842 19323-19327 NNP denotes Fig.
T13841 19322-19323 -LRB- denotes (
T13840 19313-19321 VB denotes observed
T13839 19309-19312 RB denotes not
T13838 19304-19308 VB denotes were
T13837 19289-19303 NN denotes concentrations
T13836 19276-19288 JJ denotes experimental
T13835 19273-19275 IN denotes at
T13834 19262-19272 NN denotes inhibitors
T13833 19253-19261 JJ denotes chemical
T13832 19249-19252 DT denotes the
T13831 19246-19248 IN denotes by
T13830 19241-19245 NN denotes PBMC
T13829 19238-19240 IN denotes on
T13828 19230-19237 NN denotes effects
T13827 19220-19229 JJ denotes Cytotoxic
T13826 19208-19218 NN denotes inhibition
T13825 19205-19207 IN denotes of
T13823 19192-19196 JJ denotes same
T13822 19188-19191 DT denotes the
T13821 19181-19187 VB denotes showed
T13820 19172-19180 NN denotes LY294002
T13819 19168-19171 CC denotes and
T13818 19163-19167 NN denotes PDTC
T13817 19160-19162 TO denotes to
T13816 19151-19159 NN denotes addition
T13815 19148-19150 IN denotes in
T13814 19137-19147 NN denotes inhibitors
T13813 19131-19136 JJ denotes other
T13812 19127-19130 DT denotes The
T13622 18069-18071 TO denotes to
T13621 18059-18068 JJ denotes important
T13620 18055-18058 VB denotes was
T13619 18052-18054 PRP denotes it
T13618 18050-18051 -COMMA- denotes ,
T13617 18046-18050 NN denotes PBMC
T13616 18043-18045 NN denotes RA
T13615 18040-18042 IN denotes in
T13614 18029-18039 NN denotes production
T13613 18023-18028 NN denotes IL-17
T13612 18013-18022 VB denotes increased
T13611 18009-18012 DT denotes the
T13610 18000-18008 VB denotes observed
T13609 17993-17999 VB denotes Having
T13608 17987-17992 NN denotes drugs
T13607 17972-17986 JJ denotes anti-rheumatic
T13606 17968-17971 CC denotes and
T13605 17957-17967 NN denotes inhibitors
T13604 17944-17956 NN denotes transduction
T13603 17937-17943 NN denotes signal
T13602 17934-17936 IN denotes by
T13601 17923-17933 NN denotes production
T13600 17917-17922 NN denotes IL-17
T13599 17914-17916 IN denotes of
T13598 17903-17913 NN denotes Inhibition
T13811 19124-19125 -RRB- denotes )
T13810 19122-19124 NN denotes 4a
T13809 19117-19121 NN denotes Fig.
T13808 19116-19117 -LRB- denotes (
T13807 19105-19115 NN denotes inhibitors
T13806 19096-19104 JJ denotes chemical
T13805 19091-19095 IN denotes with
T13804 19080-19090 NN denotes production
T13803 19074-19079 NN denotes IL-17
T13802 19071-19073 IN denotes of
T13801 19059-19070 NN denotes inhibitions
T13800 19044-19058 JJ denotes dose-dependent
T13799 19039-19043 VB denotes were
T13798 19033-19038 EX denotes There
T13797 19027-19031 NN denotes PBMC
T13796 19024-19026 IN denotes in
T13795 19013-19023 NN denotes production
T13794 19007-19012 NN denotes IL-17
T13793 19004-19006 IN denotes of
T13792 18993-19003 NN denotes inhibition
T13791 18989-18992 DT denotes the
T13790 18985-18988 IN denotes for
T13789 18976-18984 NN denotes LY294002
T13788 18972-18975 CC denotes and
T13787 18967-18971 NN denotes PDTC
T13786 18964-18966 IN denotes of
T13785 18955-18963 NN denotes response
T13784 18950-18954 NN denotes dose
T13783 18946-18949 DT denotes the
T13782 18937-18945 VB denotes observed
T13781 18934-18936 PRP denotes we
T13780 18932-18933 -COMMA- denotes ,
T13779 18918-18932 NN denotes concentrations
T13778 18913-18917 JJ denotes high
T13777 18910-18912 IN denotes at
T13776 18905-18909 NN denotes drug
T13775 18901-18904 DT denotes the
T13774 18898-18900 IN denotes by
T13773 18887-18897 NN denotes inhibition
T13772 18874-18886 JJ denotes non-specific
T13771 18871-18873 IN denotes of
T13770 18859-18870 NN denotes possibility
T13769 18855-18858 DT denotes the
T13768 18846-18854 VB denotes evaluate
T13767 18843-18845 TO denotes To
T13766 18840-18841 -RRB- denotes )
T13765 18839-18840 CD denotes 3
T13764 18834-18838 NN denotes Fig.
T13763 18833-18834 -LRB- denotes (
T13762 18826-18832 NN denotes levels
T13761 18820-18825 NN denotes IL-17
T13760 18817-18819 IN denotes on
T13759 18810-18816 NN denotes effect
T13758 18807-18809 DT denotes no
T13757 18803-18806 VB denotes had
T13756 18795-18802 NN denotes PD98059
T13755 18791-18794 CC denotes and
T13754 18781-18790 NN denotes rapamycin
T13753 18773-18780 IN denotes whereas
T13752 18771-18772 -COMMA- denotes ,
T13751 18768-18771 VB denotes did
T13750 18759-18767 NN denotes SB203580
T13749 18749-18758 NN denotes inhibitor
T13748 18745-18748 NN denotes p38
T13747 18743-18744 -RRB- denotes )
T13746 18739-18743 NN denotes MAPK
T13745 18738-18739 -LRB- denotes (
T13744 18731-18737 NN denotes kinase
T13743 18723-18730 NN denotes protein
T13742 18705-18722 JJ denotes mitogen-activated
T13741 18701-18704 DT denotes the
T13740 18698-18700 IN denotes as
T13739 18693-18697 RB denotes well
T13738 18690-18692 RB denotes as
T13737 18680-18689 NN denotes secretion
T13736 18674-18679 NN denotes IL-17
T13735 18670-18673 DT denotes the
T13734 18656-18669 VB denotes downregulated
T13733 18651-18655 RB denotes also
T13732 18645-18650 NN denotes FK506
T13731 18641-18644 CC denotes and
T13730 18639-18640 NN denotes A
T13729 18627-18638 NN denotes cyclosporin
T13728 18616-18626 NN denotes inhibitors
T13727 18604-18615 NN denotes calcineurin
T13726 18600-18603 DT denotes The
T13725 18597-18598 -RRB- denotes )
T13724 18585-18597 RB denotes respectively
T13723 18583-18584 -COMMA- denotes ,
T13722 18582-18583 -RRB- denotes ]
T13721 18578-18582 CD denotes 0.05
T13720 18576-18577 SYM denotes <
T13719 18574-18575 NN denotes P
T13718 18573-18574 -LRB- denotes [
T13717 18567-18572 NN denotes pg/ml
T13716 18565-18566 CD denotes 4
T13715 18563-18564 CC denotes ±
T13714 18560-18562 CD denotes 48
T13713 18556-18559 CC denotes and
T13712 18554-18555 -RRB- denotes ]
T13711 18549-18554 CD denotes 0.005
T13710 18547-18548 SYM denotes <
T13709 18545-18546 NN denotes P
T13708 18544-18545 -LRB- denotes [
T13707 18538-18543 NN denotes pg/ml
T13706 18535-18537 CD denotes 10
T13705 18533-18534 SYM denotes ±
T13704 18530-18532 CD denotes 38
T13703 18523-18529 IN denotes versus
T13702 18520-18522 CD denotes 19
T13701 18518-18519 SYM denotes ±
T13700 18515-18517 CD denotes 98
T13699 18514-18515 -LRB- denotes (
T13698 18509-18513 NN denotes PBMC
T13697 18506-18508 NN denotes RA
T13696 18503-18505 IN denotes in
T13695 18492-18502 NN denotes production
T13694 18486-18491 NN denotes IL-17
T13693 18469-18485 JJ denotes anti-CD3-induced
T13692 18465-18468 DT denotes the
T13691 18455-18464 VB denotes inhibited
T13690 18446-18454 RB denotes markedly
T13689 18441-18445 RB denotes also
T13688 18439-18440 -COMMA- denotes ,
T13687 18435-18439 NN denotes PI3K
T13686 18432-18434 IN denotes of
T13685 18422-18431 NN denotes inhibitor
T13684 18419-18421 DT denotes an
T13683 18416-18418 IN denotes as
T13682 18414-18415 -COMMA- denotes ,
T13681 18404-18414 NN denotes wortmannin
T13680 18400-18403 CC denotes and
T13679 18391-18399 NN denotes LY294002
T13678 18388-18389 -RRB- denotes )
T13677 18384-18388 CD denotes 0.05
T13676 18382-18383 SYM denotes <
T13675 18380-18381 NN denotes P
T13674 18378-18379 -COLON- denotes ;
T13673 18366-18378 RB denotes respectively
T13672 18364-18365 -COMMA- denotes ,
T13671 18359-18364 NN denotes pg/ml
T13670 18356-18358 CD denotes 19
T13669 18354-18355 SYM denotes ±
T13668 18351-18353 CD denotes 98
T13667 18344-18350 IN denotes versus
T13666 18341-18343 CD denotes 11
T13665 18339-18340 CC denotes ±
T13664 18336-18338 CD denotes 54
T13663 18332-18335 CC denotes and
T13662 18330-18331 CD denotes 5
T13661 18328-18329 CC denotes ±
T13660 18325-18327 CD denotes 38
T13659 18324-18325 -LRB- denotes (
T13658 18318-18323 RB denotes alone
T13657 18309-18317 NN denotes anti-CD3
T13656 18304-18308 IN denotes with
T13655 18293-18303 NN denotes comparison
T13654 18290-18292 IN denotes in
T13653 18276-18289 NN denotes dexamethasone
T13652 18272-18275 CC denotes and
T13651 18267-18271 NN denotes PDTC
T13650 18265-18266 -COMMA- denotes ,
T13649 18256-18265 NN denotes inhibitor
T13648 18250-18255 NN denotes NF-κB
T13647 18245-18249 IN denotes with
T13646 18232-18244 VB denotes co-incubated
T13645 18227-18231 WRB denotes when
T13644 18218-18226 VB denotes observed
T13643 18214-18217 VB denotes was
T13642 18203-18213 NN denotes production
T13641 18197-18202 NN denotes IL-17
T13640 18180-18196 JJ denotes anti-CD3-induced
T13639 18177-18179 IN denotes in
T13638 18168-18176 NN denotes decrease
T13637 18156-18167 JJ denotes significant
T13636 18153-18155 DT denotes an
T13635 18151-18152 -COMMA- denotes ,
T13634 18150-18151 CD denotes 3
T13633 18145-18149 NNP denotes Fig.
T13632 18142-18144 IN denotes in
T13631 18130-18141 VB denotes illustrated
T13630 18127-18129 IN denotes As
T13629 18117-18125 VB denotes involved
T13628 18112-18116 VB denotes were
T13627 18103-18111 NN denotes pathways
T13626 18090-18102 NN denotes transduction
T13625 18083-18089 NN denotes signal
T13624 18077-18082 WDT denotes which
T13623 18072-18076 VB denotes know
T12809 17841-17843 CD denotes 10
T12808 17840-17841 -LRB- denotes (
T12807 17835-17839 NN denotes IL-8
T12806 17830-17834 IN denotes with
T12805 17821-17829 VB denotes observed
T12804 17817-17820 VB denotes was
T12803 17812-17816 NN denotes none
T12802 17804-17811 IN denotes whereas
T12801 17802-17803 -COMMA- denotes ,
T12800 17801-17802 -RRB- denotes )
T12799 17797-17801 CD denotes 0.05
T12798 17795-17796 SYM denotes <
T12797 17793-17794 NN denotes P
T12796 17791-17792 -COLON- denotes ;
T12795 17779-17791 RB denotes respectively
T12794 17777-17778 -COMMA- denotes ,
T12793 17772-17777 NN denotes pg/ml
T12792 17769-17771 CD denotes 11
T12791 17767-17768 SYM denotes ±
T12790 17764-17766 CD denotes 31
T12789 17757-17763 IN denotes versus
T12788 17754-17756 CD denotes 10
T12787 17752-17753 SYM denotes ±
T12786 17749-17751 CD denotes 50
T12785 17745-17748 CC denotes and
T12784 17742-17744 CD denotes 42
T12783 17740-17741 CC denotes ±
T12782 17737-17739 CD denotes 62
T12781 17736-17737 -LRB- denotes (
T12780 17727-17735 VB denotes observed
T12779 17722-17726 VB denotes were
T12778 17713-17721 NN denotes proteins
T12777 17707-17712 NN denotes IL-17
T12776 17704-17706 IN denotes of
T12775 17690-17703 NN denotes upregulations
T12774 17678-17689 JJ denotes significant
T12773 17676-17677 -COMMA- denotes ,
T12772 17675-17676 -RRB- denotes )
T12771 17670-17675 NN denotes ng/ml
T12770 17667-17669 CD denotes 10
T12769 17666-17667 -LRB- denotes (
T12768 17661-17665 NN denotes IL-6
T12767 17658-17660 CC denotes or
T12766 17656-17657 -RRB- denotes )
T12765 17651-17656 NN denotes ng/ml
T12764 17648-17650 CD denotes 10
T12763 17647-17648 -LRB- denotes (
T12762 17641-17646 NN denotes MCP-1
T12761 17636-17640 IN denotes with
T12760 17628-17635 VB denotes treated
T12759 17623-17627 WRB denotes When
T12758 17620-17621 -RRB- denotes )
T12757 17618-17620 NN denotes 2a
T12756 17613-17617 NN denotes Fig.
T12755 17612-17613 -LRB- denotes (
T12754 17602-17611 JJ denotes unchanged
T12753 17597-17601 VB denotes were
T12752 17591-17596 NN denotes IL-17
T12751 17588-17590 IN denotes in
T12750 17581-17587 NN denotes levels
T12749 17577-17580 DT denotes the
T12748 17575-17576 -RRB- denotes )
T12747 17570-17575 NN denotes ng/ml
T12746 17567-17569 CD denotes 10
T12745 17566-17567 -LRB- denotes (
T12744 17560-17565 NN denotes TGF-β
T12743 17557-17559 CC denotes or
T12742 17555-17556 -RRB- denotes )
T12741 17550-17555 NN denotes ng/ml
T12740 17547-17549 CD denotes 10
T12739 17546-17547 -LRB- denotes (
T12738 17540-17545 NN denotes IL-18
T12737 17538-17539 -COMMA- denotes ,
T12736 17537-17538 -RRB- denotes )
T12735 17532-17537 NN denotes ng/ml
T12734 17529-17531 CD denotes 10
T12733 17528-17529 -LRB- denotes (
T12732 17522-17527 NN denotes TNF-α
T12731 17520-17521 -COMMA- denotes ,
T12730 17519-17520 -RRB- denotes )
T12729 17514-17519 NN denotes ng/ml
T12728 17511-17513 CD denotes 10
T12727 17510-17511 -LRB- denotes (
T12726 17504-17509 NN denotes IL-1β
T12725 17499-17503 IN denotes with
T12724 17491-17498 IN denotes whereas
T12723 17489-17490 -COMMA- denotes ,
T12722 17488-17489 -RRB- denotes )
T12721 17483-17488 NN denotes ng/ml
T12720 17480-17482 CD denotes 10
T12719 17479-17480 -LRB- denotes (
T12718 17473-17478 NN denotes IL-15
T12717 17468-17472 IN denotes with
T12716 17456-17467 NN denotes stimulation
T12715 17450-17455 IN denotes after
T12714 17444-17449 NN denotes level
T12713 17438-17443 NN denotes IL-17
T12712 17435-17437 IN denotes in
T12711 17426-17434 NN denotes increase
T12710 17423-17425 DT denotes an
T12709 17414-17422 VB denotes detected
T12708 17411-17413 PRP denotes We
T12707 17399-17409 NN denotes production
T12706 17393-17398 NN denotes IL-17
T12705 17390-17392 IN denotes on
T12704 17379-17389 NN denotes chemokines
T12703 17375-17378 CC denotes and
T12702 17365-17374 NN denotes cytokines
T12701 17357-17364 JJ denotes several
T12700 17354-17356 IN denotes of
T12699 17346-17353 NN denotes effects
T12698 17342-17345 DT denotes the
T12697 17335-17341 VB denotes tested
T12696 17332-17334 PRP denotes we
T12695 17330-17331 -COMMA- denotes ,
T12694 17326-17330 NN denotes PBMC
T12693 17316-17325 VB denotes activated
T12692 17313-17315 IN denotes by
T12691 17304-17312 VB denotes released
T12690 17294-17303 NN denotes cytokines
T12689 17281-17293 JJ denotes inflammatory
T12688 17278-17280 IN denotes of
T12687 17270-17277 NN denotes effects
T12686 17266-17269 DT denotes the
T12685 17257-17265 VB denotes evaluate
T12684 17254-17256 TO denotes To
T12683 17247-17252 NN denotes cells
T12682 17245-17246 NN denotes T
T12681 17240-17244 IN denotes from
T12680 17234-17239 NN denotes IL-17
T12679 17231-17233 IN denotes of
T12678 17220-17230 NN denotes production
T12677 17216-17219 DT denotes the
T12676 17207-17215 VB denotes affected
T12675 17202-17206 VB denotes have
T12674 17196-17201 MD denotes might
T12673 17184-17195 NN denotes lymphocytes
T12672 17178-17183 JJ denotes other
T12671 17174-17177 CC denotes and
T12670 17162-17173 NN denotes macrophages
T12669 17157-17161 IN denotes from
T12668 17148-17156 VB denotes released
T12667 17138-17147 NN denotes cytokines
T12666 17125-17137 JJ denotes inflammatory
T12665 17120-17124 DT denotes some
T12664 17118-17119 -COMMA- denotes ,
T12663 17113-17118 NN denotes cells
T12662 17111-17112 NN denotes T
T12661 17108-17110 TO denotes to
T12660 17099-17107 NN denotes addition
T12659 17096-17098 IN denotes in
T12658 17090-17095 NN denotes types
T12657 17085-17089 NN denotes cell
T12656 17077-17084 JJ denotes several
T12655 17069-17076 VB denotes include
T12654 17064-17068 NN denotes PBMC
T12653 17061-17063 NN denotes RA
T12652 17053-17060 IN denotes Because
T12651 17042-17052 NN denotes chemokines
T12650 17038-17041 CC denotes and
T12649 17028-17037 NN denotes cytokines
T12648 17015-17027 JJ denotes inflammatory
T12647 17012-17014 IN denotes by
T12646 17007-17011 NN denotes PBMC
T12645 17004-17006 NN denotes RA
T12644 17001-17003 IN denotes in
T12643 16990-17000 NN denotes production
T12642 16984-16989 NN denotes IL-17
T12641 16981-16983 IN denotes of
T12640 16970-16980 NN denotes Regulation
T12827 17899-17900 -RRB- denotes )
T12826 17897-17899 NN denotes 2b
T12825 17892-17896 NN denotes Fig.
T12824 17891-17892 -LRB- denotes (
T12823 17889-17890 -RRB- denotes )
T12822 17884-17889 NN denotes ng/ml
T12821 17881-17883 CD denotes 10
T12820 17880-17881 -LRB- denotes (
T12819 17873-17879 NN denotes MIP-1β
T12818 17870-17872 CC denotes or
T12817 17868-17869 -RRB- denotes )
T12816 17863-17868 NN denotes ng/ml
T12815 17860-17862 CD denotes 10
T12814 17859-17860 -LRB- denotes (
T12813 17852-17858 NN denotes MIP-1α
T12812 17850-17851 -COMMA- denotes ,
T12811 17849-17850 -RRB- denotes )
T12810 17844-17849 NN denotes ng/ml
T11847 16402-16403 NN denotes T
T11846 16400-16401 DT denotes a
T11845 16397-16399 IN denotes as
T11844 16395-16396 -RRB- denotes )
T11843 16390-16395 NN denotes μg/ml
T11842 16387-16389 CD denotes 10
T11841 16383-16386 CC denotes and
T11840 16381-16382 CD denotes 5
T11839 16379-16380 -COMMA- denotes ,
T11838 16378-16379 CD denotes 1
T11837 16377-16378 -LRB- denotes (
T11836 16368-16376 NN denotes anti-CD3
T11835 16365-16367 IN denotes of
T11834 16350-16364 NN denotes concentrations
T11833 16340-16349 JJ denotes different
T11832 16337-16339 IN denotes of
T11831 16330-16336 NN denotes effect
T11830 16326-16329 DT denotes the
T11829 16313-16325 VB denotes investigated
T11828 16310-16312 PRP denotes we
T11827 16308-16309 -COMMA- denotes ,
T11826 16303-16308 NN denotes cells
T11825 16301-16302 NN denotes T
T11824 16291-16300 VB denotes activated
T11823 16288-16290 IN denotes by
T11822 16281-16287 RB denotes mainly
T11821 16272-16280 VB denotes produced
T11820 16269-16271 VB denotes be
T11819 16266-16268 TO denotes to
T11818 16258-16265 NN denotes reports
T11817 16250-16257 JJ denotes earlier
T11816 16245-16249 IN denotes from
T11815 16239-16244 VB denotes known
T11814 16231-16238 RB denotes already
T11813 16227-16230 VB denotes was
T11812 16221-16226 NN denotes IL-17
T11811 16213-16220 IN denotes Because
T11810 16209-16212 NN denotes PHA
T11809 16205-16208 CC denotes and
T11808 16203-16204 -COMMA- denotes ,
T11807 16194-16203 NN denotes anti-CD28
T11806 16187-16193 CC denotes and/or
T11805 16178-16186 JJ denotes anti-CD3
T11804 16175-16177 IN denotes by
T11803 16172-16174 NN denotes RA
T11802 16167-16171 IN denotes with
T11801 16158-16166 NN denotes patients
T11800 16155-16157 IN denotes of
T11799 16150-16154 NN denotes PBMC
T11798 16147-16149 IN denotes in
T11797 16136-16146 NN denotes production
T11796 16130-16135 NN denotes IL-17
T11795 16120-16129 VB denotes Increased
T11948 16966-16967 -RRB- denotes )
T11947 16962-16966 CD denotes 0.05
T11946 16960-16961 SYM denotes <
T11945 16958-16959 NN denotes P
T11944 16956-16957 -COLON- denotes ;
T11943 16951-16956 NN denotes pg/ml
T11942 16949-16950 CD denotes 1
T11941 16947-16948 SYM denotes ±
T11940 16943-16946 CD denotes 211
T11939 16936-16942 IN denotes versus
T11938 16933-16935 CD denotes 85
T11937 16931-16932 SYM denotes ±
T11936 16927-16930 CD denotes 588
T11935 16926-16927 -LRB- denotes (
T11934 16916-16925 JJ denotes anti-CD28
T11933 16912-16915 CC denotes and
T11932 16903-16911 JJ denotes anti-CD3
T11931 16898-16902 IN denotes with
T11930 16893-16897 IN denotes than
T11929 16882-16892 JJ denotes pronounced
T11928 16877-16881 RB denotes more
T11927 16873-16876 VB denotes was
T11926 16862-16872 NN denotes production
T11925 16856-16861 NN denotes IL-17
T11924 16846-16855 VB denotes increased
T11923 16844-16845 -COMMA- denotes ,
T11922 16841-16844 NN denotes PHA
T11921 16838-16840 IN denotes as
T11920 16833-16837 JJ denotes such
T11919 16824-16832 NN denotes mitogens
T11918 16819-16823 NN denotes cell
T11917 16817-16818 NN denotes T
T11916 16812-16816 IN denotes with
T11915 16802-16811 VB denotes incubated
T11914 16797-16801 WRB denotes when
T11913 16795-16796 -COMMA- denotes ,
T11912 16784-16795 RB denotes Furthermore
T11911 16777-16782 RB denotes alone
T11910 16768-16776 NN denotes anti-CD3
T11909 16763-16767 IN denotes than
T11908 16761-16762 -RRB- denotes )
T11907 16749-16761 RB denotes 1.3-1.5-fold
T11906 16735-16748 RB denotes approximately
T11905 16734-16735 -LRB- denotes (
T11904 16728-16733 NN denotes IL-17
T11903 16723-16727 JJ denotes more
T11902 16714-16722 VB denotes produced
T11901 16705-16713 NN denotes anti-CD3
T11900 16701-16704 CC denotes and
T11899 16691-16700 NN denotes anti-CD28
T11898 16688-16690 IN denotes of
T11897 16676-16687 NN denotes combination
T11896 16672-16675 DT denotes the
T11895 16668-16671 CC denotes and
T11894 16666-16667 -COMMA- denotes ,
T11893 16658-16666 RB denotes 3.7-fold
T11892 16655-16657 TO denotes to
T11891 16652-16654 IN denotes up
T11890 16641-16651 NN denotes production
T11889 16635-16640 NN denotes IL-17
T11888 16623-16634 VB denotes upregulated
T11887 16609-16622 RB denotes significantly
T11886 16600-16608 JJ denotes anti-CD3
T11885 16598-16599 -COMMA- denotes ,
T11884 16597-16598 CD denotes 1
T11883 16591-16596 JJ denotes Table
T11882 16588-16590 IN denotes in
T11881 16582-16587 VB denotes shown
T11880 16579-16581 IN denotes As
T11879 16569-16577 NN denotes anti-CD3
T11878 16565-16568 IN denotes for
T11877 16551-16564 NN denotes concentration
T11876 16539-16550 NN denotes stimulation
T11875 16537-16538 DT denotes a
T11874 16534-16536 IN denotes as
T11873 16528-16533 NN denotes μg/ml
T11872 16525-16527 CD denotes 10
T11871 16519-16524 VB denotes chose
T11870 16516-16518 PRP denotes we
T11869 16514-16515 -COMMA- denotes ,
T11868 16510-16514 DT denotes this
T11867 16507-16509 IN denotes of
T11866 16501-16506 NN denotes basis
T11865 16497-16500 DT denotes the
T11864 16494-16496 IN denotes On
T11863 16491-16492 -RRB- denotes )
T11862 16486-16491 VB denotes shown
T11861 16482-16485 RB denotes not
T11860 16477-16481 NN denotes data
T11859 16476-16477 -LRB- denotes (
T11858 16469-16475 NN denotes levels
T11857 16463-16468 NN denotes IL-17
T11856 16460-16462 IN denotes in
T11855 16451-16459 NN denotes increase
T11854 16436-16450 JJ denotes dose-dependent
T11853 16434-16435 DT denotes a
T11852 16427-16433 VB denotes showed
T11851 16421-16426 WDT denotes which
T11850 16419-16420 -COMMA- denotes ,
T11849 16409-16419 NN denotes activation
T11848 16404-16408 NN denotes cell
T11372 16116-16117 -RRB- denotes )
T11371 16115-16116 -RRB- denotes ]
T11370 16110-16115 CD denotes 0.001
T11369 16108-16109 SYM denotes <
T11368 16106-16107 NN denotes P
T11367 16105-16106 -LRB- denotes [
T11366 16099-16104 NN denotes pg/ml
T11365 16096-16098 CD denotes 29
T11364 16094-16095 SYM denotes ±
T11363 16090-16093 CD denotes 241
T11362 16086-16089 CC denotes and
T11361 16084-16085 -RRB- denotes ]
T11360 16080-16084 CD denotes 0.05
T11359 16078-16079 SYM denotes <
T11358 16076-16077 NN denotes P
T11357 16075-16076 -LRB- denotes [
T11356 16069-16074 NN denotes pg/ml
T11355 16065-16068 CD denotes 211
T11354 16063-16064 SYM denotes ±
T11353 16059-16062 CD denotes 463
T11352 16052-16058 IN denotes versus
T11351 16048-16051 CD denotes 295
T11350 16046-16047 SYM denotes ±
T11349 16042-16045 CD denotes 768
T11348 16041-16042 -LRB- denotes (
T11347 16032-16040 NN denotes controls
T11346 16028-16031 CC denotes and
T11345 16025-16027 NN denotes OA
T11344 16020-16024 IN denotes from
T11343 16014-16019 DT denotes those
T11342 16011-16013 IN denotes in
T11341 16006-16010 IN denotes than
T11340 16001-16005 NN denotes PBMC
T11339 15998-16000 NN denotes RA
T11338 15995-15997 IN denotes in
T11337 15988-15994 JJ denotes higher
T11336 15974-15987 RB denotes significantly
T11335 15970-15973 VB denotes was
T11334 15966-15969 NN denotes PHA
T11333 15963-15965 IN denotes by
T11332 15952-15962 VB denotes stimulated
T11331 15941-15951 NN denotes production
T11330 15935-15940 NN denotes IL-17
T11329 15931-15934 DT denotes the
T11328 15929-15930 -COMMA- denotes ,
T11327 15928-15929 -RRB- denotes )
T11326 15916-15928 RB denotes respectively
T11325 15914-15915 -COMMA- denotes ,
T11324 15909-15914 NN denotes pg/ml
T11292 15770-15774 NN denotes Fig.
T11291 15769-15770 -LRB- denotes (
T11290 15756-15768 NN denotes supernatants
T11289 15748-15755 NN denotes culture
T11288 15744-15747 DT denotes the
T11287 15741-15743 IN denotes in
T11286 15730-15740 VB denotes determined
T11285 15725-15729 RB denotes then
T11284 15720-15724 VB denotes were
T11283 15713-15719 NN denotes levels
T11282 15707-15712 NN denotes IL-17
T11281 15705-15706 -COLON- denotes ;
T11280 15697-15705 NN denotes controls
T11279 15690-15696 JJ denotes normal
T11278 15678-15689 JJ denotes age-matched
T11277 15674-15677 CC denotes and
T11276 15672-15673 -COMMA- denotes ,
T11275 15670-15672 NN denotes OA
T11274 15665-15669 IN denotes with
T11273 15656-15664 NN denotes patients
T11272 15654-15655 -COMMA- denotes ,
T11271 15652-15654 NN denotes RA
T11270 15647-15651 IN denotes with
T11269 15638-15646 NN denotes patients
T11268 15633-15637 IN denotes from
T11267 15631-15632 -RRB- denotes )
T11266 15626-15631 NN denotes μg/ml
T11265 15624-15625 CD denotes 5
T11264 15623-15624 -LRB- denotes (
T11263 15619-15622 NN denotes PHA
T11262 15614-15618 IN denotes with
T11261 15605-15613 VB denotes cultured
T11260 15601-15604 CC denotes and
T11259 15591-15600 VB denotes separated
T11258 15586-15590 VB denotes were
T11257 15581-15585 NN denotes PBMC
T11256 15569-15580 NN denotes individuals
T11255 15562-15568 JJ denotes normal
T11254 15558-15561 CC denotes and
T11253 15555-15557 NN denotes OA
T11252 15550-15554 IN denotes with
T11251 15541-15549 NN denotes patients
T11250 15539-15540 -COMMA- denotes ,
T11249 15537-15539 NN denotes RA
T11248 15532-15536 IN denotes with
T11247 15523-15531 NN denotes patients
T11246 15518-15522 IN denotes from
T11245 15513-15517 NN denotes PBMC
T11244 15510-15512 IN denotes in
T11243 15499-15509 NN denotes production
T11242 15493-15498 NN denotes IL-17
T11044 15459-15469 VB denotes considered
T11043 15454-15458 VB denotes were
T11042 15449-15453 CD denotes 0.05
T11041 15444-15448 IN denotes than
T11040 15439-15443 JJ denotes less
T11039 15432-15438 NN denotes values
T11038 15430-15431 NN denotes P
T11037 15423-15428 NN denotes pairs
T11036 15415-15422 JJ denotes matched
T11035 15411-15414 IN denotes for
T11034 15404-15410 NN denotes t-test
T11033 15401-15403 POS denotes 's
T11032 15394-15401 NN denotes Student
T11031 15389-15393 IN denotes with
T11030 15379-15388 VB denotes performed
T11029 15375-15378 VB denotes was
T11028 15366-15374 NN denotes analysis
T11027 15354-15365 JJ denotes Statistical
T11026 15349-15352 NN denotes SEM
T11025 15347-15348 CC denotes ±
T11024 15341-15346 NN denotes means
T11023 15338-15340 IN denotes as
T11022 15328-15337 VB denotes expressed
T11021 15324-15327 VB denotes are
T11020 15319-15323 NN denotes Data
T11019 15310-15318 NN denotes analysis
T11018 15298-15309 JJ denotes Statistical
T11323 15906-15908 CD denotes 10
T11322 15904-15905 SYM denotes ±
T11321 15901-15903 CD denotes 43
T11320 15897-15900 CC denotes and
T11319 15894-15896 CD denotes 19
T11318 15892-15893 SYM denotes ±
T11317 15889-15891 CD denotes 43
T11316 15887-15888 -COMMA- denotes ,
T11315 15885-15887 CD denotes 31
T11314 15883-15884 SYM denotes ±
T11313 15880-15882 CD denotes 62
T11312 15879-15880 -LRB- denotes (
T11311 15870-15878 NN denotes controls
T11310 15863-15869 JJ denotes normal
T11309 15859-15862 CC denotes and
T11308 15856-15858 NN denotes OA
T11307 15854-15855 -COMMA- denotes ,
T11306 15852-15854 NN denotes RA
T11305 15844-15851 IN denotes between
T11304 15834-15843 JJ denotes different
T11303 15830-15833 RB denotes not
T11302 15825-15829 VB denotes were
T11301 15815-15824 NN denotes secretion
T11300 15809-15814 NN denotes IL-17
T11299 15803-15808 JJ denotes basal
T11298 15800-15802 IN denotes of
T11297 15792-15799 NN denotes amounts
T11296 15788-15791 DT denotes the
T11295 15779-15787 IN denotes Although
T11294 15776-15777 -RRB- denotes )
T11293 15775-15776 CD denotes 1
T10895 15294-15295 -RRB- denotes ]
T10894 15292-15294 CD denotes 21
T10893 15291-15292 -LRB- denotes [
T10892 15289-15290 -RRB- denotes )
T10891 15284-15289 NN denotes cells
T10890 15279-15283 JJ denotes dead
T10889 15275-15278 CC denotes and
T10888 15268-15274 JJ denotes viable
T10887 15263-15267 CC denotes both
T10886 15260-15262 IN denotes of
T10885 15247-15259 NN denotes cells/number
T10884 15240-15246 JJ denotes viable
T10883 15237-15239 IN denotes of
T10882 15230-15236 NN denotes number
T10881 15229-15230 -LRB- denotes (
T10880 15227-15228 NN denotes ×
T10879 15223-15226 CD denotes 100
T10878 15215-15222 NN denotes formula
T10877 15211-15214 DT denotes the
T10876 15206-15210 IN denotes with
T10875 15195-15205 VB denotes calculated
T10874 15191-15194 VB denotes was
T10873 15181-15190 NN denotes viability
T10872 15176-15180 NN denotes cell
T10871 15165-15175 NN denotes percentage
T10870 15161-15164 DT denotes the
T10869 15157-15160 CC denotes and
T10868 15147-15156 VB denotes harvested
T10867 15142-15146 VB denotes were
T10866 15136-15141 NN denotes cells
T10865 15132-15135 DT denotes the
T10864 15130-15131 -COMMA- denotes ,
T10863 15125-15130 NN denotes hours
T10862 15122-15124 CD denotes 24
T10861 15118-15121 IN denotes for
T10860 15107-15117 NN denotes incubation
T10859 15101-15106 IN denotes After
T10858 15094-15099 NN denotes cells
T10857 15091-15093 IN denotes on
T10856 15080-15090 NN denotes inhibitors
T10855 15077-15079 IN denotes of
T10854 15070-15076 NN denotes effect
T10853 15060-15069 JJ denotes cytotoxic
T10852 15053-15059 JJ denotes direct
T10851 15050-15052 IN denotes of
T10850 15040-15049 NN denotes potential
T10849 15036-15039 DT denotes the
T10848 15027-15035 VB denotes evaluate
T10847 15024-15026 TO denotes to
T10846 15019-15023 VB denotes used
T10845 15015-15018 VB denotes was
T10844 15008-15014 NN denotes method
T10843 14998-15007 NN denotes exclusion
T10842 14994-14997 NN denotes dye
T10841 14989-14993 JJ denotes blue
T10840 14982-14988 NN denotes trypan
T10839 14978-14981 DT denotes the
T10838 14976-14977 -COMMA- denotes ,
T10837 14970-14976 NN denotes assays
T10836 14960-14969 NN denotes viability
T10835 14955-14959 NN denotes cell
T10834 14951-14954 IN denotes For
T10833 14949-14950 -RRB- denotes )
T10832 14944-14949 NN denotes assay
T10831 14934-14943 NN denotes exclusion
T10830 14930-14933 NN denotes dye
T10829 14925-14929 JJ denotes blue
T11045 15470-15481 JJ denotes significant
T10828 14918-14924 NN denotes Trypan
T10827 14917-14918 -LRB- denotes (
T10826 14907-14916 NN denotes viability
T10825 14902-14906 NN denotes Cell
T10409 14898-14899 -RRB- denotes )
T10408 14895-14898 NNP denotes USA
T10407 14893-14894 -COMMA- denotes ,
T10406 14891-14893 NNP denotes CA
T10405 14889-14890 -COMMA- denotes ,
T10404 14885-14889 NNP denotes Cruz
T10403 14879-14884 NNP denotes Santa
T10402 14878-14879 -LRB- denotes (
T10401 14864-14877 NNP denotes Biotechnology
T10400 14859-14863 NNP denotes Cruz
T10399 14853-14858 NNP denotes Santa
T10398 14848-14852 IN denotes from
T10397 14843-14847 VB denotes were
T10396 14837-14842 NN denotes c-Rel
T10395 14833-14836 CC denotes and
T10394 14829-14832 NN denotes p65
T10393 14827-14828 -COMMA- denotes ,
T10392 14824-14827 NN denotes p50
T10391 14815-14823 NN denotes subunits
T10390 14809-14814 NN denotes NF-κB
T10389 14801-14808 IN denotes against
T10388 14790-14800 NN denotes antibodies
T10387 14779-14789 JJ denotes polyclonal
T10386 14772-14778 NN denotes Rabbit
T10385 14763-14770 NN denotes screens
T10384 14750-14762 VB denotes intensifying
T10383 14745-14749 IN denotes with
T10382 14739-14744 NN denotes -70°C
T10381 14736-14738 IN denotes at
T10380 14731-14735 NN denotes film
T10379 14724-14730 NN denotes X-OMAT
T10378 14718-14723 VB denotes Kodak
T10377 14715-14717 TO denotes to
T10376 14707-14714 VB denotes exposed
T10375 14703-14706 CC denotes and
T10374 14696-14702 NN denotes vacuum
T10373 14690-14695 IN denotes under
T10372 14684-14689 VB denotes dried
T10371 14679-14683 VB denotes were
T10370 14674-14678 NNP denotes Gels
T10369 14671-14673 NNP denotes V.
T10368 14667-14670 CD denotes 100
T10367 14664-14666 IN denotes at
T10366 14662-14663 -RRB- denotes )
T10365 14659-14662 CD denotes 8.0
T10364 14656-14658 NN denotes pH
T10363 14655-14656 -LRB- denotes (
T10362 14648-14654 NN denotes buffer
T10361 14631-14647 NN denotes Tris-borate-EDTA
T10360 14629-14630 SYM denotes ×
T10359 14625-14628 CD denotes 0.5
T10358 14622-14624 IN denotes in
T10357 14617-14621 NN denotes gels
T10356 14602-14616 NN denotes polyacrylamide
T10355 14600-14601 NN denotes %
T10354 14599-14600 CD denotes 5
T10353 14585-14598 JJ denotes nondenaturing
T10352 14582-14584 IN denotes on
T10351 14566-14581 NN denotes electrophoresis
T10350 14563-14565 TO denotes to
T10349 14553-14562 VB denotes subjected
T10348 14548-14552 VB denotes were
T10347 14540-14547 NN denotes Samples
T10346 14537-14538 -RRB- denotes )
T10345 14532-14537 NN denotes dI-dC
T10344 14531-14532 -LRB- denotes (
T10343 14527-14531 NN denotes poly
T10342 14521-14526 NN denotes ng/μl
T10341 14518-14520 CD denotes 50
T10340 14514-14517 CC denotes and
T10339 14510-14513 NN denotes P40
T10338 14502-14509 NN denotes Nonidet
T10337 14500-14501 NN denotes %
T10336 14497-14500 CD denotes 0.2
T10335 14495-14496 -COMMA- denotes ,
T10334 14492-14495 NN denotes BSA
T10333 14486-14491 NN denotes mg/ml
T10332 14484-14485 CD denotes 1
T10331 14482-14483 -COMMA- denotes ,
T10330 14474-14482 NN denotes glycerol
T10329 14472-14473 NN denotes %
T10328 14471-14472 CD denotes 5
T10327 14469-14470 -COMMA- denotes ,
T10326 14465-14469 NN denotes EDTA
T10325 14462-14464 NN denotes mM
T10324 14458-14461 CD denotes 0.5
T10323 14456-14457 -COMMA- denotes ,
T10322 14442-14456 NN denotes dithiothreitol
T10321 14439-14441 NN denotes mM
T10320 14437-14438 CD denotes 1
T10319 14435-14436 -COMMA- denotes ,
T10318 14432-14435 NN denotes KCl
T10317 14429-14431 NN denotes mM
T10316 14426-14428 CD denotes 50
T10315 14424-14425 -COMMA- denotes ,
T10314 14421-14424 CD denotes 7.9
T10313 14418-14420 NN denotes pH
T10312 14416-14417 -COMMA- denotes ,
T10311 14408-14416 NN denotes Tris-HCl
T10310 14405-14407 NN denotes mM
T10309 14402-14404 CD denotes 20
T10308 14399-14401 IN denotes of
T10307 14388-14398 VB denotes consisting
T10306 14381-14387 NN denotes buffer
T10305 14373-14380 NN denotes binding
T10304 14370-14372 IN denotes of
T10303 14367-14369 NN denotes μl
T10302 14364-14366 CD denotes 20
T10301 14361-14363 IN denotes in
T10300 14349-14360 NN denotes temperature
T10299 14344-14348 NN denotes room
T10298 14341-14343 IN denotes at
T10297 14337-14340 NN denotes min
T10296 14334-14336 CD denotes 30
T10295 14330-14333 IN denotes for
T10294 14328-14329 -RRB- denotes )
T10293 14322-14328 NN denotes c.p.m.
T10292 14314-14321 CD denotes 100,000
T10291 14312-14313 -COLON- denotes ;
T10290 14310-14312 NN denotes ng
T10289 14307-14309 CD denotes 10
T10288 14306-14307 -LRB- denotes (
T10287 14299-14305 NN denotes probes
T10286 14295-14298 NN denotes DNA
T10285 14282-14294 VB denotes radiolabeled
T10284 14277-14281 IN denotes with
T10283 14267-14276 VB denotes incubated
T10282 14262-14266 VB denotes were
T10281 14260-14261 -RRB- denotes )
T10280 14253-14260 NN denotes protein
T10279 14250-14252 IN denotes of
T10278 14247-14249 NN denotes μg
T10277 14245-14246 CD denotes 2
T10276 14244-14245 -LRB- denotes (
T10275 14235-14243 NN denotes extracts
T10274 14227-14234 JJ denotes Nuclear
T10273 14224-14225 -RRB- denotes )
T10272 14221-14224 NNP denotes USA
T10271 14219-14220 -COMMA- denotes ,
T10270 14217-14219 NNP denotes CA
T10269 14215-14216 -COMMA- denotes ,
T10268 14210-14215 NNP denotes Jolla
T10267 14207-14209 NNP denotes La
T10266 14205-14206 -COMMA- denotes ,
T10265 14195-14205 NNP denotes Stratagene
T10264 14194-14195 -LRB- denotes (
T10263 14186-14193 NN denotes columns
T10262 14173-14185 NN denotes purification
T10261 14167-14172 NN denotes probe
T10260 14159-14166 NN denotes NucTrap
T10259 14156-14158 IN denotes by
T10258 14148-14155 VB denotes removed
T10257 14143-14147 VB denotes were
T10256 14131-14142 NN denotes nucleotides
T10255 14116-14130 JJ denotes Unincorporated
T10254 14113-14114 -RRB- denotes )
T10253 14107-14113 NN denotes TaKaRa
T10252 14106-14107 -LRB- denotes (
T10251 14099-14105 NN denotes kinase
T10250 14084-14098 NN denotes polynucleotide
T10249 14081-14083 NN denotes T4
T10248 14077-14080 CC denotes and
T10247 14075-14076 -RRB- denotes )
T10246 14066-14075 NNP denotes Pharmacia
T10245 14057-14065 NNP denotes Amersham
T10244 14056-14057 -LRB- denotes (
T10243 14051-14055 NN denotes dATP
T10242 14050-14051 -RRB- denotes ]
T10241 14045-14050 NN denotes γ-32P
T10240 14044-14045 -LRB- denotes [
T10239 14039-14043 IN denotes with
T10238 14032-14038 NN denotes strand
T10237 14026-14031 NN denotes sense
T10236 14022-14025 DT denotes the
T10235 14019-14021 IN denotes of
T10234 14010-14018 NN denotes labeling
T10233 14003-14009 JJ denotes 5'-end
T10232 14000-14002 IN denotes by
T10231 13990-13999 VB denotes generated
T10230 13985-13989 VB denotes were
T10229 13983-13984 -RRB- denotes )
T10228 13982-13983 -DQE- denotes '
T10227 13977-13982 NN denotes TTC-3
T10226 13973-13976 NN denotes AAA
T10225 13969-13972 NN denotes CCA
T10224 13965-13968 NN denotes TAC
T10223 13961-13964 NN denotes AAA
T10222 13957-13960 NN denotes TGG
T10221 13953-13956 NN denotes ACC
T10220 13946-13952 NN denotes 5'-ATG
T10219 13945-13946 -LRB- denotes (
T10218 13936-13944 NN denotes promoter
T10217 13930-13935 NN denotes IL-17
T10216 13924-13929 JJ denotes human
T10215 13920-13923 DT denotes the
T10214 13917-13919 IN denotes of
T10213 13912-13916 NN denotes site
T10212 13904-13911 NN denotes binding
T10211 13898-13903 NN denotes NF-κB
T10210 13894-13897 DT denotes the
T10209 13881-13893 VB denotes encompassing
T10208 13874-13880 NN denotes probes
T10207 13858-13873 NN denotes Oligonucleotide
T10206 13852-13856 NN denotes PBMC
T10205 13848-13851 CD denotes 106
T10204 13846-13847 SYM denotes ×
T10203 13844-13845 CD denotes 5
T10202 13838-13843 IN denotes about
T10201 13833-13837 IN denotes from
T10200 13823-13832 VB denotes extracted
T10199 13818-13822 VB denotes were
T10198 13809-13817 NN denotes proteins
T10197 13801-13808 JJ denotes Nuclear
T10196 13796-13800 NN denotes site
T10195 13788-13795 NN denotes binding
T10194 13782-13787 NN denotes NF-κB
T10193 13779-13781 IN denotes of
T10192 13773-13778 NN denotes assay
T10191 13758-13772 JJ|NN denotes mobility-shift
T10190 13754-13757 NN denotes Gel
T9604 13750-13751 -RRB- denotes )
T9603 13741-13750 NNP denotes Pharmacia
T9602 13732-13740 NNP denotes Amersham
T9601 13731-13732 -LRB- denotes (
T9600 13722-13730 NN denotes reagents
T9599 13708-13721 NN denotes Hyperfilm-ECL
T9598 13704-13707 CC denotes and
T9597 13700-13703 NN denotes kit
T9596 13690-13699 NN denotes detection
T9595 13688-13689 -RRB- denotes )
T9594 13685-13688 NN denotes ECL
T9593 13684-13685 -LRB- denotes (
T9592 13666-13683 NN denotes chemiluminescence
T9591 13657-13665 VB denotes enhanced
T9590 13653-13656 DT denotes the
T9589 13648-13652 IN denotes with
T9588 13639-13647 VB denotes detected
T9587 13634-13638 VB denotes were
T9586 13628-13633 NN denotes bands
T9585 13617-13627 VB denotes hybridized
T9584 13615-13616 -COMMA- denotes ,
T9583 13608-13615 NN denotes washing
T9582 13602-13607 NN denotes TBS-T
T9581 13596-13601 IN denotes After
T9580 13583-13594 NN denotes temperature
T9579 13578-13582 NN denotes room
T9578 13575-13577 IN denotes at
T9577 13570-13574 NN denotes hour
T9576 13568-13569 CD denotes 1
T9575 13564-13567 IN denotes for
T9574 13555-13563 VB denotes incubate
T9573 13552-13554 TO denotes to
T9572 13544-13551 VB denotes allowed
T9571 13540-13543 CC denotes and
T9570 13534-13539 VB denotes added
T9569 13529-13533 VB denotes were
T9568 13518-13528 NN denotes antibodies
T9567 13508-13517 JJ denotes secondary
T9566 13486-13507 JJ denotes peroxidase-conjugated
T9565 13474-13485 JJ denotes horseradish
T9564 13472-13473 -COMMA- denotes ,
T9563 13467-13472 NN denotes TBS-T
T9562 13462-13466 IN denotes with
T9561 13456-13461 NN denotes times
T9560 13451-13455 CD denotes four
T9559 13443-13450 VB denotes washing
T9558 13437-13442 IN denotes After
T9557 13432-13435 NN denotes 4°C
T9556 13429-13431 IN denotes at
T9555 13419-13428 RB denotes overnight
T9554 13409-13418 VB denotes incubated
T9553 13405-13408 CC denotes and
T9552 13399-13404 VB denotes added
T9551 13394-13398 VB denotes were
T9550 13392-13393 -COMMA- denotes ,
T9549 13383-13392 NN denotes BSA/TBS-T
T9548 13381-13382 NN denotes %
T9547 13380-13381 CD denotes 5
T9546 13377-13379 IN denotes in
T9545 13372-13376 CD denotes 1000
T9544 13371-13372 -COLON- denotes :
T9543 13370-13371 CD denotes 1
T9542 13362-13369 VB denotes diluted
T9541 13360-13361 -COMMA- denotes ,
T9540 13359-13360 -RRB- denotes )
T9539 13356-13359 NNP denotes USA
T9538 13354-13355 -COMMA- denotes ,
T9537 13352-13354 NNP denotes MA
T9536 13350-13351 -COMMA- denotes ,
T9535 13343-13350 NNP denotes Beverly
T9534 13341-13342 -COMMA- denotes ,
T9533 13337-13341 NNP denotes Inc.
T9532 13326-13336 NNP denotes Technology
T9531 13316-13325 NNP denotes Signaling
T9530 13311-13315 NNP denotes Cell
T9529 13310-13311 -LRB- denotes (
T9528 13304-13309 NN denotes IκB-α
T9527 13300-13303 CC denotes and
T9526 13296-13299 NN denotes Akt
T9525 13281-13295 VB denotes phosphorylated
T9524 13279-13280 -COMMA- denotes ,
T9523 13276-13279 NNP denotes Akt
T9522 13268-13275 IN denotes against
T9521 13257-13267 NN denotes antibodies
T9520 13249-13256 JJ denotes primary
T9519 13244-13248 RB denotes then
T9518 13242-13243 -COMMA- denotes ,
T9517 13237-13242 NN denotes hours
T9516 13235-13236 CD denotes 2
T9515 13231-13234 IN denotes for
T9514 13219-13230 NN denotes temperature
T9513 13214-13218 NN denotes room
T9512 13211-13213 IN denotes at
T9511 13209-13210 -RRB- denotes )
T9510 13203-13209 NN denotes saline
T9509 13189-13202 JJ denotes Tris-buffered
T9508 13186-13188 IN denotes in
T9507 13183-13185 CD denotes 20
T9506 13177-13182 CD denotes Tween
T9505 13175-13176 NN denotes %
T9504 13172-13175 CD denotes 0.1
T9503 13171-13172 -LRB- denotes (
T9502 13164-13170 NN denotes buffer
T9501 13158-13163 NN denotes TBS-T
T9500 13155-13157 IN denotes in
T9499 13150-13154 NN denotes milk
T9498 13142-13149 VB denotes skimmed
T9497 13140-13141 NN denotes %
T9496 13137-13140 CD denotes 0.1
T9495 13132-13136 IN denotes with
T9494 13119-13131 VB denotes preincubated
T9493 13115-13118 VB denotes was
T9492 13106-13114 NN denotes membrane
T9491 13104-13105 -COMMA- denotes ,
T9490 13091-13104 NN denotes hybridization
T9489 13083-13090 JJ denotes western
T9488 13079-13082 IN denotes For
T9487 13076-13077 -RRB- denotes )
T9486 13070-13076 NNP denotes Sweden
T9485 13068-13069 -COMMA- denotes ,
T9484 13061-13068 NNP denotes Uppsala
T9483 13059-13060 -COMMA- denotes ,
T9482 13052-13059 NNP denotes Biotech
T9481 13042-13051 NNP denotes Pharmacia
T9480 13033-13041 NNP denotes Amersham
T9479 13032-13033 -LRB- denotes (
T9478 13023-13031 NN denotes membrane
T9477 13008-13022 NN denotes nitrocellulose
T9476 13006-13007 DT denotes a
T9475 13003-13005 TO denotes to
T9474 12991-13002 VB denotes transferred
T9473 12987-12990 CC denotes and
T9472 12978-12986 NN denotes SDS–PAGE
T9471 12976-12977 NN denotes %
T9470 12974-12976 CD denotes 10
T9469 12971-12973 IN denotes by
T9468 12961-12970 VB denotes separated
T9467 12956-12960 VB denotes were
T9466 12948-12955 NN denotes samples
T9465 12940-12947 NN denotes Protein
T9464 12937-12938 -RRB- denotes )
T9463 12934-12937 NNP denotes USA
T9462 12932-12933 -COMMA- denotes ,
T9461 12930-12932 NNP denotes CA
T9460 12928-12929 -COMMA- denotes ,
T9459 12920-12928 NNP denotes Hercules
T9458 12918-12919 -COMMA- denotes ,
T9457 12911-12918 NNP denotes Bio-Rad
T9456 12910-12911 -LRB- denotes (
T9455 12903-12909 NN denotes method
T9454 12894-12902 NNP denotes Bradford
T9453 12890-12893 DT denotes the
T9452 12885-12889 IN denotes with
T9451 12874-12884 VB denotes determined
T9450 12869-12873 VB denotes were
T9449 12856-12868 NN denotes supernatants
T9448 12852-12855 DT denotes the
T9447 12849-12851 IN denotes in
T9446 12834-12848 NN denotes concentrations
T9445 12826-12833 NN denotes Protein
T9444 12821-12824 NN denotes min
T9443 12818-12820 CD denotes 15
T9442 12814-12817 IN denotes for
T9441 12812-12813 -RRB- denotes )
T9440 12811-12812 NN denotes g
T9439 12804-12810 CD denotes 19,000
T9438 12803-12804 -LRB- denotes (
T9437 12796-12802 NN denotes r.p.m.
T9436 12789-12795 CD denotes 14,000
T9435 12786-12788 IN denotes at
T9434 12774-12785 VB denotes centrifuged
T9433 12770-12773 CC denotes and
T9432 12768-12769 -COMMA- denotes ,
T9431 12762-12768 NN denotes buffer
T9430 12756-12761 NN denotes lysis
T9429 12752-12755 DT denotes the
T9428 12749-12751 IN denotes in
T9427 12734-12748 NN denotes homogenization
T9426 12731-12733 IN denotes by
T9425 12725-12730 NN denotes cells
T9424 12721-12724 CD denotes 107
T9423 12715-12720 IN denotes about
T9422 12710-12714 IN denotes from
T9421 12701-12709 VB denotes prepared
T9420 12696-12700 VB denotes were
T9419 12688-12695 NN denotes lysates
T9418 12683-12687 NN denotes cell
T9417 12677-12682 JJ denotes whole
T9403 12616-12618 CC denotes or
T9402 12607-12615 NN denotes presence
T9401 12603-12606 DT denotes the
T9400 12600-12602 IN denotes in
T9399 12598-12599 -RRB- denotes )
T9398 12593-12598 NN denotes μg/ml
T9397 12590-12592 CD denotes 10
T9396 12589-12590 -LRB- denotes (
T9395 12580-12588 NN denotes anti-CD3
T9394 12575-12579 IN denotes with
T9393 12565-12574 VB denotes incubated
T9392 12560-12564 VB denotes were
T9391 12555-12559 NN denotes PBMC
T9390 12549-12554 NN denotes IκB-α
T9389 12545-12548 CC denotes and
T9388 12541-12544 NN denotes Akt
T9387 12526-12540 VB denotes phosphorylated
T9386 12524-12525 -COMMA- denotes ,
T9385 12521-12524 NN denotes Akt
T9384 12518-12520 IN denotes of
T9383 12509-12517 NN denotes analysis
T9382 12504-12508 NN denotes blot
T9381 12496-12503 NN denotes Western
T9416 12675-12676 -COMMA- denotes ,
T9415 12671-12675 NN denotes hour
T9414 12669-12670 CD denotes 1
T9413 12665-12668 IN denotes for
T9412 12654-12664 NN denotes incubation
T9411 12648-12653 IN denotes After
T9410 12645-12646 -RRB- denotes )
T9409 12643-12645 NN denotes μM
T9408 12640-12642 CD denotes 20
T9407 12639-12640 -LRB- denotes (
T9406 12630-12638 NN denotes LY294002
T9405 12627-12629 IN denotes of
T9404 12619-12626 NN denotes absence
T7744 10760-10768 VB denotes plotting
T7743 10757-10759 IN denotes by
T7742 10751-10756 VB denotes drawn
T7741 10747-10750 VB denotes was
T7740 10741-10746 NN denotes curve
T7739 10732-10740 JJ denotes standard
T7738 10730-10731 DT denotes A
T7737 10723-10728 NN denotes pg/ml
T7736 10718-10722 CD denotes 2000
T7735 10715-10717 TO denotes to
T7734 10712-10714 CD denotes 10
T7733 10707-10711 IN denotes from
T7732 10699-10706 VB denotes ranging
T7731 10697-10698 -COMMA- denotes ,
T7730 10689-10697 NN denotes standard
T7729 10677-10688 NN denotes calibration
T7728 10675-10676 DT denotes a
T7727 10672-10674 IN denotes as
T7726 10667-10671 VB denotes used
T7725 10663-10666 VB denotes was
T7724 10656-10662 NN denotes medium
T7723 10648-10655 NN denotes culture
T7722 10645-10647 IN denotes in
T7721 10637-10644 VB denotes diluted
T7720 10631-10636 NN denotes IL-17
T7719 10625-10630 JJ denotes human
T7718 10613-10624 JJ denotes Recombinant
T7717 10606-10611 NN denotes pg/ml
T7716 10603-10605 CD denotes 10
T7715 10599-10602 VB denotes was
T7714 10589-10598 NN denotes detection
T7713 10583-10588 NN denotes IL-17
T7712 10580-10582 IN denotes of
T7711 10574-10579 NN denotes limit
T7710 10568-10573 JJ denotes lower
T7709 10564-10567 DT denotes The
T7708 10560-10562 NN denotes nm
T7707 10556-10559 CD denotes 405
T7706 10553-10555 IN denotes at
T7705 10548-10552 VB denotes read
T7704 10544-10547 VB denotes was
T7703 10539-10543 NN denotes well
T7702 10534-10538 DT denotes each
T7701 10531-10533 IN denotes of
T7700 10523-10530 NN denotes density
T7699 10515-10522 JJ denotes optical
T7698 10511-10514 DT denotes the
T7697 10507-10510 CC denotes and
T7696 10502-10506 NN denotes NaOH
T7695 10500-10501 NN denotes M
T7694 10498-10499 CD denotes 1
T7693 10495-10497 IN denotes of
T7692 10486-10494 NN denotes addition
T7691 10482-10485 DT denotes the
T7690 10479-10481 IN denotes by
T7689 10471-10478 VB denotes stopped
T7688 10467-10470 VB denotes was
T7687 10458-10466 NN denotes reaction
T7686 10454-10457 DT denotes The
T7685 10444-10452 NN denotes reaction
T7684 10438-10443 NN denotes color
T7683 10434-10437 DT denotes the
T7682 10426-10433 VB denotes develop
T7681 10423-10425 TO denotes to
T7680 10421-10422 -RRB- denotes )
T7679 10416-10421 NN denotes Sigma
T7678 10415-10416 -LRB- denotes (
T7677 10400-10414 NN denotes diethanolamine
T7676 10397-10399 IN denotes in
T7675 10387-10396 VB denotes dissolved
T7674 10385-10386 -RRB- denotes )
T7673 10380-10385 NN denotes Sigma
T7672 10379-10380 -LRB- denotes (
T7671 10369-10378 NN denotes phosphate
T7670 10355-10368 NN denotes p-nitrophenyl
T7669 10349-10354 NN denotes mg/ml
T7668 10347-10348 CD denotes 1
T7667 10342-10346 IN denotes with
T7666 10332-10341 VB denotes incubated
T7665 10328-10331 CC denotes and
T7664 10322-10327 RB denotes again
T7663 10315-10321 VB denotes washed
T7662 10310-10314 RB denotes then
T7661 10308-10309 -COMMA- denotes ,
T7660 10303-10308 NN denotes hours
T7659 10301-10302 CD denotes 2
T7658 10297-10300 IN denotes for
T7657 10287-10296 VB denotes incubated
T7656 10283-10286 VB denotes was
T7655 10281-10282 -RRB- denotes )
T7654 10276-10281 NN denotes Sigma
T7653 10275-10276 -LRB- denotes (
T7652 10265-10274 NN denotes conjugate
T7651 10254-10264 NN denotes peroxidase
T7650 10232-10253 JJ denotes phosphate–horseradish
T7649 10210-10231 JJ denotes streptavidin–alkaline
T7648 10208-10209 -COMMA- denotes ,
T7647 10201-10208 VB denotes washing
T7646 10195-10200 IN denotes After
T7645 10182-10193 NN denotes temperature
T7644 10177-10181 NN denotes room
T7643 10174-10176 IN denotes at
T7642 10168-10173 NN denotes hours
T7641 10166-10167 CD denotes 2
T7640 10162-10165 IN denotes for
T7639 10160-10161 -RRB- denotes )
T7638 10153-10160 NNP denotes Systems
T7637 10151-10152 NNP denotes D
T7636 10149-10150 CC denotes &
T7635 10147-10148 NN denotes R
T7634 10146-10147 -LRB- denotes (
T7633 10140-10145 NN denotes IL-17
T7632 10132-10139 IN denotes against
T7631 10121-10131 NN denotes antibodies
T7630 10110-10120 JJ denotes monoclonal
T7629 10104-10109 NN denotes mouse
T7628 10091-10103 VB denotes biotinylated
T7627 10085-10090 NN denotes ng/ml
T7626 10081-10084 CD denotes 500
T7625 10076-10080 IN denotes with
T7624 10066-10075 VB denotes incubated
T7623 10061-10065 RB denotes then
T7622 10057-10060 CC denotes and
T7621 10055-10056 -COMMA- denotes ,
T7620 10053-10055 CD denotes 20
T7619 10040-10052 NN denotes saline/Tween
T7618 10021-10039 JJ denotes phosphate-buffered
T7617 10016-10020 IN denotes with
T7616 10010-10015 NN denotes times
T7615 10005-10009 CD denotes four
T7614 9998-10004 VB denotes washed
T7613 9993-9997 VB denotes were
T7612 9986-9992 NN denotes Plates
T7611 9979-9984 NN denotes hours
T7610 9977-9978 CD denotes 2
T7609 9973-9976 IN denotes for
T7608 9961-9972 NN denotes temperature
T7607 9956-9960 NN denotes room
T7606 9953-9955 IN denotes at
T7605 9943-9952 VB denotes incubated
T7604 9939-9942 CC denotes and
T7603 9933-9938 NN denotes plate
T7602 9925-9932 JJ denotes 96-well
T7601 9921-9924 DT denotes the
T7600 9918-9920 TO denotes to
T7599 9912-9917 VB denotes added
T7598 9907-9911 VB denotes were
T7597 9905-9906 -RRB- denotes )
T7596 9898-9905 NNP denotes Systems
T7595 9896-9897 NNP denotes D
T7594 9894-9895 CC denotes &
T7593 9892-9893 NN denotes R
T7592 9891-9892 -LRB- denotes (
T7591 9885-9890 NN denotes IL-17
T7590 9873-9884 JJ denotes recombinant
T7589 9864-9872 JJ denotes standard
T7588 9860-9863 DT denotes the
T7587 9856-9859 CC denotes and
T7586 9848-9855 NN denotes samples
T7585 9843-9847 NN denotes test
T7584 9841-9842 -COMMA- denotes ,
T7583 9840-9841 -RRB- denotes )
T7582 9833-9840 NN denotes 22–25°C
T7581 9832-9833 -LRB- denotes (
T7580 9820-9831 NN denotes temperature
T7579 9815-9819 NN denotes room
T7578 9812-9814 IN denotes at
T7577 9806-9811 NN denotes hours
T7576 9804-9805 CD denotes 2
T7575 9800-9803 IN denotes for
T7574 9797-9799 CD denotes 20
T7573 9791-9796 CD denotes Tween
T7572 9789-9790 NN denotes %
T7571 9784-9789 CD denotes /0.05
T7570 9783-9784 -RRB- denotes )
T7569 9780-9783 NN denotes BSA
T7568 9779-9780 -LRB- denotes (
T7567 9771-9778 NN denotes albumin
T7566 9765-9770 NN denotes serum
T7565 9758-9764 JJ denotes bovine
T7564 9756-9757 NN denotes %
T7563 9748-9756 NN denotes saline/1
T7562 9729-9747 JJ denotes phosphate-buffered
T7561 9724-9728 IN denotes with
T7560 9715-9723 VB denotes blocking
T7559 9709-9714 IN denotes After
T7558 9698-9707 RB denotes overnight
T7557 9694-9697 NN denotes 4°C
T7556 9691-9693 IN denotes at
T7555 9689-9690 -RRB- denotes )
T7554 9682-9689 NNP denotes Systems
T7553 9680-9681 NNP denotes D
T7552 9678-9679 CC denotes &
T7551 9676-9677 NN denotes R
T7550 9675-9676 -LRB- denotes (
T7549 9669-9674 NN denotes IL-17
T7548 9661-9668 IN denotes against
T7547 9650-9660 NN denotes antibodies
T7546 9639-9649 JJ denotes monoclonal
T7545 9633-9638 NN denotes μg/ml
T7544 9631-9632 CD denotes 4
T7543 9626-9630 IN denotes with
T7542 9619-9625 VB denotes coated
T7541 9615-9618 VB denotes was
T7540 9613-9614 -RRB- denotes )
T7539 9609-9613 NN denotes Nunc
T7538 9608-9609 -LRB- denotes (
T7537 9602-9607 NN denotes plate
T7536 9594-9601 JJ denotes 96-well
T7535 9592-9593 DT denotes a
T7534 9590-9591 -COMMA- denotes ,
T7533 9585-9590 NN denotes brief
T7532 9582-9584 IN denotes In
T7531 9579-9580 -RRB- denotes ]
T7530 9577-9579 CD denotes 20
T7529 9576-9577 -LRB- denotes [
T7765 10892-10899 NN denotes samples
T7764 10887-10891 NN denotes test
T7763 10884-10886 IN denotes in
T7762 10878-10883 NN denotes IL-17
T7761 10875-10877 IN denotes of
T7760 10861-10874 NN denotes determination
T7759 10857-10860 IN denotes for
T7758 10852-10856 VB denotes used
T7757 10848-10851 CC denotes and
T7756 10846-10847 -COMMA- denotes ,
T7755 10837-10846 NN denotes cytokines
T7754 10825-10836 JJ denotes recombinant
T7753 10822-10824 IN denotes of
T7752 10808-10821 NN denotes concentration
T7751 10804-10807 DT denotes the
T7750 10801-10803 IN denotes of
T7749 10797-10800 NN denotes log
T7748 10793-10796 DT denotes the
T7747 10785-10792 IN denotes against
T7746 10777-10784 NN denotes density
T7745 10769-10776 JJ denotes optical
T6929 9411-9417 NN denotes marker
T6928 9406-9410 NN denotes cell
T6927 9404-9405 NN denotes T
T6926 9400-9403 NN denotes CD4
T6925 9396-9399 DT denotes the
T6924 9392-9395 VB denotes had
T7528 9565-9575 RB denotes previously
T7527 9555-9564 VB denotes described
T7526 9552-9554 IN denotes as
T7525 9546-9551 NN denotes assay
T7524 9532-9545 JJ denotes immunosorbent
T7523 9518-9531 JJ denotes enzyme-linked
T7522 9509-9517 JJ denotes sandwich
T7521 9506-9508 IN denotes by
T7520 9497-9505 VB denotes measured
T7519 9493-9496 VB denotes was
T7518 9480-9492 NN denotes supernatants
T7517 9472-9479 NN denotes culture
T7516 9469-9471 IN denotes in
T7515 9463-9468 NN denotes IL-17
T7514 9457-9462 NN denotes IL-17
T7513 9454-9456 IN denotes of
T7512 9448-9453 NN denotes assay
T7511 9434-9447 JJ denotes immunosorbent
T7510 9420-9433 JJ denotes Enzyme-linked
T6923 9386-9391 NN denotes cells
T6922 9377-9385 VB denotes isolated
T6921 9373-9376 DT denotes the
T6920 9370-9372 IN denotes of
T6919 9368-9369 -RRB- denotes )
T6918 9367-9368 NN denotes %
T6917 9365-9367 CD denotes 97
T6916 9360-9364 IN denotes than
T6915 9355-9359 JJ denotes more
T6914 9354-9355 -LRB- denotes (
T6913 9349-9353 JJ denotes Most
T6912 9341-9347 NN denotes sorter
T6911 9333-9340 NNP denotes Vantage
T6910 9328-9332 NNP denotes FACS
T6909 9326-9327 DT denotes a
T6908 9323-9325 IN denotes on
T6907 9317-9322 NN denotes cells
T6906 9309-9316 VB denotes stained
T6905 9306-9308 IN denotes of
T6904 9297-9305 NN denotes analysis
T6903 9286-9296 JJ denotes cytometric
T6902 9281-9285 NN denotes flow
T6901 9278-9280 IN denotes by
T6900 9269-9277 VB denotes assessed
T6899 9265-9268 VB denotes was
T6898 9259-9264 NN denotes cells
T6897 9256-9258 IN denotes of
T6896 9249-9255 NN denotes purity
T6895 9245-9248 DT denotes The
T6894 9238-9243 RB denotes above
T6893 9228-9237 VB denotes described
T6892 9225-9227 IN denotes as
T6891 9215-9224 VB denotes separated
T6890 9202-9214 RB denotes magnetically
T6889 9198-9201 CC denotes and
T6888 9196-9197 -COMMA- denotes ,
T6887 9195-9196 -RRB- denotes )
T6886 9189-9195 NN denotes 6–12°C
T6885 9187-9188 -COMMA- denotes ,
T6884 9184-9187 NN denotes min
T6883 9181-9183 CD denotes 15
T6882 9179-9180 -COLON- denotes ;
T6881 9169-9179 NN denotes suspension
T6880 9164-9168 NN denotes cell
T6879 9161-9163 IN denotes of
T6878 9158-9160 NN denotes μl
T6877 9155-9157 CD denotes 80
T6876 9152-9154 TO denotes to
T6875 9146-9151 VB denotes added
T6874 9143-9145 NN denotes μl
T6873 9140-9142 CD denotes 20
T6872 9139-9140 -LRB- denotes (
T6871 9128-9138 NN denotes microbeads
T6870 9109-9127 JJ denotes anti-phycoerythrin
T6869 9104-9108 IN denotes with
T6868 9096-9103 VB denotes labeled
T6867 9083-9095 RB denotes magnetically
T6866 9081-9082 -COMMA- denotes ,
T6865 9075-9081 VB denotes washed
T6864 9070-9074 VB denotes were
T6863 9047-9069 NN denotes anti-CD4–phycoerythrin
T6862 9042-9046 IN denotes with
T6861 9034-9041 VB denotes stained
T6860 9028-9033 NN denotes cells
T6859 9026-9027 -COMMA- denotes ,
T6858 9013-9026 RB denotes Alternatively
T6857 9005-9011 NN denotes magnet
T6856 9001-9004 DT denotes the
T6855 8996-9000 IN denotes from
T6854 8988-8995 NN denotes removal
T6853 8982-8987 IN denotes after
T6852 8975-8981 NN denotes column
T6851 8971-8974 DT denotes the
T6850 8966-8970 IN denotes from
T6849 8957-8965 NN denotes aliquots
T6848 8954-8956 NN denotes ml
T6847 8950-8953 CD denotes 0.5
T6846 8946-8949 CD denotes two
T6845 8943-8945 IN denotes in
T6844 8933-8942 VB denotes collected
T6843 8928-8932 VB denotes were
T6842 8922-8927 NN denotes cells
T6841 8913-8921 VB denotes Enriched
T6840 8903-8911 NN denotes fraction
T6839 8894-8902 JJ denotes negative
T6838 8890-8893 DT denotes the
T6837 8887-8889 IN denotes as
T6836 8877-8886 VB denotes collected
T6835 8872-8876 VB denotes were
T6834 8865-8871 NN denotes washes
T6833 8862-8864 NN denotes ml
T6832 8860-8861 CD denotes 1
T6831 8856-8859 CD denotes two
T6830 8852-8855 CC denotes and
T6829 8839-8851 JJ denotes Flow-through
T6828 8831-8837 NN denotes column
T6827 8828-8830 NN denotes MS
T6826 8823-8827 NN denotes MACS
T6825 8821-8822 DT denotes a
T6824 8816-8820 IN denotes with
T6823 8809-8815 VB denotes fitted
T6822 8802-8808 NN denotes magnet
T6821 8793-8801 NN denotes AutoMACS
T6820 8790-8792 DT denotes an
T6819 8787-8789 IN denotes on
T6818 8779-8786 RB denotes usually
T6817 8777-8778 -COMMA- denotes ,
T6816 8768-8777 VB denotes separated
T6815 8755-8767 RB denotes magnetically
T6814 8751-8754 CC denotes and
T6813 8748-8750 NN denotes μl
T6812 8744-8747 CD denotes 500
T6811 8741-8743 IN denotes in
T6810 8729-8740 VB denotes resuspended
T6809 8727-8728 -COMMA- denotes ,
T6808 8719-8727 VB denotes pelleted
T6807 8717-8718 -COMMA- denotes ,
T6806 8711-8717 NN denotes buffer
T6805 8702-8710 NN denotes staining
T6804 8698-8701 NNP denotes FBS
T6803 8695-8697 IN denotes of
T6802 8692-8694 NN denotes ml
T6801 8688-8691 CD denotes 2.5
T6800 8685-8687 IN denotes in
T6799 8677-8684 VB denotes diluted
T6798 8672-8676 VB denotes were
T6797 8666-8671 NN denotes Cells
T6796 8661-8664 NN denotes min
T6795 8658-8660 CD denotes 10
T6794 8650-8657 JJ denotes further
T6793 8648-8649 DT denotes a
T6792 8644-8647 IN denotes for
T6791 8638-8643 VB denotes added
T6790 8633-8637 VB denotes were
T6789 8622-8632 NN denotes antibodies
T6788 8598-8621 JJ denotes fluorochrome-conjugated
T6787 8595-8597 IN denotes of
T6786 8587-8594 NN denotes amounts
T6785 8576-8586 VB denotes Saturating
T6784 8568-8574 NN denotes 6–12°C
T6783 8565-8567 IN denotes at
T6782 8561-8564 NN denotes min
T6781 8558-8560 CD denotes 15
T6780 8554-8557 IN denotes for
T6779 8544-8553 VB denotes incubated
T6778 8540-8543 CC denotes and
T6777 8534-8539 VB denotes added
T6776 8529-8533 VB denotes were
T6775 8527-8528 -RRB- denotes )
T6774 8525-8527 NN denotes μl
T6773 8522-8524 CD denotes 20
T6772 8521-8522 -LRB- denotes (
T6771 8510-8520 NN denotes microbeads
T6770 8501-8509 JJ denotes Anti-CD4
T6769 8493-8499 NN denotes buffer
T6768 8484-8492 NN denotes staining
T6767 8480-8483 NNP denotes FBS
T6766 8477-8479 IN denotes of
T6765 8474-8476 NN denotes μl
T6764 8471-8473 CD denotes 80
T6763 8468-8470 IN denotes in
T6762 8456-8467 VB denotes resuspended
T6761 8451-8455 VB denotes were
T6760 8446-8450 NN denotes PBMC
T6759 8443-8444 -RRB- denotes ]
T6758 8441-8443 CD denotes 19
T6757 8440-8441 -LRB- denotes [
T6756 8438-8439 -RRB- denotes )
T6755 8430-8438 NNP denotes Miltenyi
T6754 8429-8430 -LRB- denotes (
T6753 8416-8428 NN denotes manufacturer
T6752 8412-8415 DT denotes the
T6751 8409-8411 IN denotes by
T6750 8397-8408 VB denotes recommended
T6749 8394-8396 IN denotes as
T6748 8382-8393 RB denotes essentially
T6747 8377-8381 VB denotes used
T6746 8372-8376 VB denotes were
T6745 8361-8371 NN denotes microbeads
T6744 8352-8360 NN denotes Anti-CD4
T6743 8347-8351 NN denotes MACS
T6742 8344-8346 IN denotes by
T6741 8334-8343 NN denotes isolation
T6740 8327-8333 NN denotes T-cell
T6739 8322-8326 JJ denotes CD4+
T6278 8316-8319 NN denotes SEM
T6277 8314-8315 CC denotes ±
T6276 8308-8313 NN denotes means
T6275 8305-8307 IN denotes as
T6274 8295-8304 VB denotes expressed
T6273 8291-8294 VB denotes are
T6272 8283-8290 NN denotes results
T6271 8279-8282 CC denotes and
T6270 8277-8278 -COMMA- denotes ,
T6269 8267-8277 NN denotes triplicate
T6268 8264-8266 IN denotes in
T6267 8261-8263 RP denotes up
T6266 8257-8260 VB denotes set
T6265 8252-8256 VB denotes were
T6264 8243-8251 NN denotes cultures
T6263 8239-8242 DT denotes All
T6262 8230-8237 VB denotes assayed
T6261 8224-8229 IN denotes until
T6260 8218-8223 NN denotes -20°C
T6259 8215-8217 IN denotes at
T6258 8208-8214 VB denotes stored
T6257 8204-8207 CC denotes and
T6256 8194-8203 VB denotes collected
T6255 8189-8193 VB denotes were
T6254 8183-8188 NN denotes media
T6253 8173-8182 JJ denotes cell-free
T6252 8171-8172 -COMMA- denotes ,
T6251 8170-8171 -RRB- denotes )
T6250 8164-8170 VB denotes stated
T6249 8154-8163 RB denotes otherwise
T6248 8147-8153 IN denotes unless
T6247 8146-8147 -LRB- denotes (
T6246 8140-8145 NN denotes hours
T6245 8137-8139 CD denotes 24
T6244 8133-8136 IN denotes for
T6243 8122-8132 NN denotes incubation
T6242 8116-8121 IN denotes After
T6241 8104-8114 NN denotes wortmannin
T6240 8101-8103 CC denotes or
T6239 8087-8100 NN denotes dexamethasone
T6238 8085-8086 -COMMA- denotes ,
T6237 8078-8085 NN denotes PD98059
T6236 8076-8077 -COMMA- denotes ,
T6235 8068-8076 NN denotes SB203580
T6234 8066-8067 -COMMA- denotes ,
T6233 8058-8066 NN denotes LY294002
T6232 8056-8057 -COMMA- denotes ,
T6231 8052-8056 NN denotes PDTC
T6230 8050-8051 -COMMA- denotes ,
T6229 8042-8050 NN denotes curcumin
T6228 8040-8041 -COMMA- denotes ,
T6227 8031-8040 NN denotes rapamycin
T6226 8029-8030 -COMMA- denotes ,
T6225 8024-8029 NN denotes FK506
T6224 8018-8023 VB denotes added
T6223 8014-8017 VB denotes was
T6222 8009-8013 NN denotes well
T6221 8004-8008 DT denotes each
T6220 8001-8003 TO denotes To
T6219 7994-7999 NN denotes hours
T6207 7935-7936 -RRB- denotes )
T6206 7930-7935 NN denotes ng/ml
T6205 7923-7929 CD denotes 10–500
T6204 7922-7923 -LRB- denotes (
T6203 7920-7921 NN denotes A
T6202 7908-7919 NN denotes cyclosporin
T6201 7905-7907 IN denotes of
T6200 7890-7904 NN denotes concentrations
T6199 7882-7889 JJ denotes various
T6198 7880-7881 -COMMA- denotes ,
T6197 7868-7880 RB denotes Subsequently
T6196 7863-7866 NN denotes CO2
T6195 7861-7862 NN denotes %
T6194 7860-7861 CD denotes 5
T6193 7857-7859 IN denotes in
T6192 7852-7856 NN denotes 37°C
T6191 7849-7851 IN denotes at
T6190 7843-7848 NN denotes hours
T6189 7840-7842 CD denotes 24
T6188 7836-7839 IN denotes for
T6187 7826-7835 VB denotes incubated
T6186 7822-7825 CC denotes and
T6185 7820-7821 -COMMA- denotes ,
T6184 7819-7820 -RRB- denotes )
T6183 7812-7819 NNP denotes Denmark
T6182 7810-7811 -COMMA- denotes ,
T6181 7802-7810 NNP denotes Roskilde
T6180 7800-7801 -COMMA- denotes ,
T6179 7796-7800 NNP denotes Nunc
T6178 7795-7796 -LRB- denotes (
T6177 7788-7794 NN denotes plates
T6176 7777-7787 JJ denotes multi-well
T6175 7769-7776 JJ denotes 24-well
T6174 7764-7768 IN denotes into
T6173 7754-7763 VB denotes dispensed
T6172 7750-7753 VB denotes was
T6171 7748-7749 -RRB- denotes )
T6170 7746-7748 NN denotes ml
T6169 7744-7745 CD denotes 1
T6168 7743-7744 -LRB- denotes (
T6167 7732-7742 NN denotes suspension
T6166 7727-7731 NN denotes Cell
T6165 7714-7725 NN denotes L-glutamine
T6164 7711-7713 NN denotes mM
T6163 7709-7710 CD denotes 2
T6162 7705-7708 CC denotes and
T6161 7692-7704 NN denotes streptomycin
T6160 7686-7691 NN denotes mg/ml
T6159 7682-7685 CD denotes 100
T6158 7680-7681 -COMMA- denotes ,
T6157 7670-7680 NN denotes penicillin
T6156 7665-7669 NN denotes U/ml
T6155 7661-7664 CD denotes 100
T6154 7659-7660 -COMMA- denotes ,
T6153 7654-7659 NN denotes serum
T6152 7649-7653 NN denotes calf
T6151 7643-7648 JJ denotes fetal
T6150 7641-7642 NN denotes %
T6149 7639-7641 CD denotes 10
T6148 7634-7638 IN denotes with
T6147 7621-7633 VB denotes supplemented
T6146 7614-7620 NN denotes medium
T6145 7609-7613 CD denotes 1640
T6144 7604-7608 NN denotes RPMI
T6143 7601-7603 IN denotes in
T6142 7594-7600 NN denotes 106/ml
T6141 7591-7593 IN denotes of
T6140 7577-7590 NN denotes concentration
T6139 7575-7576 DT denotes a
T6138 7572-7574 TO denotes to
T6137 7563-7571 VB denotes adjusted
T6136 7558-7562 VB denotes were
T6135 7546-7557 NN denotes suspensions
T6134 7541-7545 NN denotes cell
T6133 7537-7540 DT denotes the
T6132 7535-7536 -COMMA- denotes ,
T6131 7530-7535 NN denotes brief
T6130 7527-7529 IN denotes In
T6129 7524-7525 -RRB- denotes ]
T6128 7522-7524 CD denotes 18
T6127 7521-7522 -LRB- denotes [
T6126 7510-7520 RB denotes previously
T6125 7500-7509 VB denotes described
T6124 7497-7499 IN denotes as
T6123 7487-7496 VB denotes performed
T6122 7482-7486 VB denotes were
T6121 7473-7481 NN denotes cultures
T6120 7468-7472 NN denotes Cell
T6119 7452-7466 NN denotes centrifugation
T6118 7435-7451 JJ denotes density-gradient
T6117 7433-7434 -RRB- denotes )
T6116 7427-7433 NN denotes SG1077
T6115 7426-7427 -LRB- denotes (
T6114 7411-7425 JJ denotes Ficoll-Hypaque
T6113 7408-7410 IN denotes by
T6112 7402-7407 NN denotes blood
T6111 7390-7401 VB denotes heparinized
T6110 7385-7389 IN denotes from
T6109 7376-7384 VB denotes prepared
T6108 7371-7375 VB denotes were
T6107 7366-7370 NN denotes PBMC
T6106 7355-7365 NN denotes chemokines
T6105 7352-7354 CC denotes or
T6104 7342-7351 NN denotes cytokines
T6103 7340-7341 -COMMA- denotes ,
T6102 7330-7340 NN denotes activation
T6101 7321-7329 NN denotes receptor
T6100 7316-7320 NN denotes cell
T6099 7314-7315 NN denotes T
T6098 7311-7313 IN denotes by
T6097 7305-7310 NN denotes IL-17
T6096 7302-7304 IN denotes of
T6095 7291-7301 NN denotes Production
T6218 7991-7993 CD denotes 24
T6217 7987-7990 IN denotes for
T6216 7977-7986 VB denotes incubated
T6215 7972-7976 VB denotes were
T6214 7966-7971 NN denotes cells
T6213 7962-7965 CC denotes and
T6212 7955-7961 NN denotes medium
T6211 7951-7954 DT denotes the
T6210 7948-7950 TO denotes to
T6209 7942-7947 VB denotes added
T6208 7937-7941 VB denotes were
T5530 7287-7288 -RRB- denotes )
T5529 7280-7287 NNP denotes Germany
T5528 7278-7279 -COMMA- denotes ,
T5527 7268-7278 NNP denotes Schwalbach
T5526 7267-7268 -LRB- denotes (
T5525 7256-7266 NN denotes Calbiochem
T5524 7251-7255 IN denotes from
T5523 7242-7250 VB denotes obtained
T5522 7237-7241 VB denotes were
T5521 7229-7236 NN denotes PD98059
T5520 7225-7228 CC denotes and
T5519 7214-7224 NN denotes wortmannin
T5518 7212-7213 -COMMA- denotes ,
T5517 7207-7212 NN denotes FK506
T5516 7205-7206 -COMMA- denotes ,
T5515 7197-7205 NN denotes SB203580
T5514 7195-7196 -COMMA- denotes ,
T5513 7187-7195 NN denotes LY294002
T5512 7184-7185 -RRB- denotes )
T5511 7181-7184 NNP denotes USA
T5510 7179-7180 -COMMA- denotes ,
T5509 7177-7179 NNP denotes CA
T5508 7175-7176 -COMMA- denotes ,
T5507 7170-7175 NNP denotes Diego
T5506 7166-7169 NNP denotes San
T5505 7165-7166 -LRB- denotes (
T5504 7153-7164 NNP denotes Biosciences
T5502 7145-7149 IN denotes from
T5501 7136-7144 VB denotes obtained
T5500 7131-7135 VB denotes were
T5499 7122-7130 NN denotes antibody
T5498 7111-7121 JJ denotes monoclonal
T5497 7101-7110 JJ denotes anti-CD28
T5496 7097-7100 CC denotes and
T5495 7088-7096 NN denotes antibody
T5494 7077-7087 JJ denotes monoclonal
T5493 7068-7076 JJ denotes Anti-CD3
T5492 7065-7066 -RRB- denotes )
T5491 7062-7065 NNP denotes USA
T5490 7060-7061 -COMMA- denotes ,
T5489 7058-7060 NNP denotes MA
T5488 7056-7057 -COMMA- denotes ,
T5487 7051-7056 NNP denotes Louis
T5486 7048-7050 NNP denotes St
T5485 7047-7048 -LRB- denotes (
T5484 7043-7046 NNP denotes Co.
T5483 7034-7042 NNP denotes Chemical
T5482 7028-7033 NNP denotes Sigma
T5481 7024-7027 DT denotes the
T5480 7019-7023 IN denotes from
T5479 7010-7018 VB denotes obtained
T5478 7006-7009 DT denotes all
T5477 7001-7005 VB denotes were
T5476 6992-7000 NN denotes curcumin
T5475 6988-6991 CC denotes and
T5474 6974-6987 NN denotes dexamethasone
T5473 6972-6973 -COMMA- denotes ,
T5472 6963-6972 NN denotes rapamycin
T5471 6961-6962 -COMMA- denotes ,
T5470 6960-6961 -RRB- denotes )
T5469 6956-6960 NN denotes PDTC
T5468 6955-6956 -LRB- denotes (
T5467 6939-6954 NN denotes dithiocarbamate
T5466 6927-6938 NN denotes pyrrolidine
T5465 6925-6926 -COMMA- denotes ,
T5464 6924-6925 -RRB- denotes )
T5463 6921-6924 NN denotes PHA
T5462 6920-6921 -LRB- denotes (
T5461 6901-6919 NN denotes Phytohemagglutinin
T5460 6898-6899 -RRB- denotes )
T5459 6887-6898 NNP denotes Switzerland
T5458 6885-6886 -COMMA- denotes ,
T5457 6880-6885 NNP denotes Basel
T5456 6879-6880 -LRB- denotes (
T5455 6874-6878 NNP denotes Ltd.
T5454 6867-6873 NNP denotes Sandos
T5453 6864-6866 IN denotes by
T5452 6855-6863 VB denotes provided
T5451 6851-6854 VB denotes was
T5450 6849-6850 NN denotes A
T5449 6837-6848 NN denotes Cyclosporin
T5448 6834-6835 -RRB- denotes )
T5447 6831-6834 NNP denotes USA
T5446 6829-6830 -COMMA- denotes ,
T5445 6827-6829 NNP denotes MA
T5444 6825-6826 -COMMA- denotes ,
T5443 6816-6825 NNP denotes Cambridge
T5442 6815-6816 -LRB- denotes (
T5441 6810-6814 NNP denotes Inc.
T5440 6802-6809 NNP denotes Endogen
T5439 6797-6801 IN denotes from
T5438 6787-6796 VB denotes purchased
T5437 6782-6786 VB denotes were
T5436 6777-6781 NN denotes IL-1
T5435 6773-6776 CC denotes and
T5434 6767-6772 NN denotes TNF-α
T5433 6755-6766 JJ denotes Recombinant
T5432 6752-6753 -RRB- denotes )
T5431 6750-6752 NNP denotes UK
T5430 6748-6749 -COMMA- denotes ,
T5429 6742-6748 NNP denotes London
T5428 6741-6742 -LRB- denotes (
T5427 6731-6740 NNP denotes Peprotech
T5426 6726-6730 IN denotes from
T5425 6716-6725 VB denotes purchased
T5424 6712-6715 VB denotes was
T5423 6709-6711 NN denotes -β
T5422 6708-6709 -RRB- denotes )
T5421 6705-6708 NN denotes TGF
T5420 6704-6705 -LRB- denotes (
T5419 6697-6703 NN denotes factor
T5418 6690-6696 NN denotes growth
T5417 6677-6689 VB denotes transforming
T5416 6665-6676 JJ denotes Recombinant
T5415 6662-6663 -RRB- denotes )
T5414 6659-6662 NNP denotes USA
T5413 6657-6658 -COMMA- denotes ,
T5412 6655-6657 NNP denotes MN
T5411 6653-6654 -COMMA- denotes ,
T5410 6642-6653 NNP denotes Minneapolis
T5409 6641-6642 -LRB- denotes (
T5408 6633-6640 NN denotes systems
T5407 6631-6632 NN denotes D
T5406 6629-6630 CC denotes &
T5405 6627-6628 NN denotes R
T5404 6622-6626 IN denotes from
T5403 6612-6621 VB denotes purchased
T5402 6607-6611 VB denotes were
T5401 6602-6606 NN denotes IL-8
T5400 6598-6601 CC denotes and
T5399 6593-6597 NN denotes IL-6
T5398 6591-6592 -COMMA- denotes ,
T5397 6585-6591 NN denotes MIP-1β
T5396 6583-6584 -COMMA- denotes ,
T5395 6580-6583 NN denotes -1α
T5394 6579-6580 -RRB- denotes )
T5393 6576-6579 NN denotes MIP
T5392 6575-6576 -LRB- denotes (
T5391 6567-6574 NN denotes protein
T5390 6554-6566 JJ denotes inflammatory
T5389 6543-6553 NN denotes macrophage
T5388 6541-6542 -COMMA- denotes ,
T5387 6540-6541 -RRB- denotes )
T5386 6535-6540 NN denotes MCP-1
T5385 6534-6535 -LRB- denotes (
T5384 6524-6533 NN denotes protein-1
T5383 6508-6523 NN denotes chemoattractant
T5382 6499-6507 NN denotes monocyte
T5381 6497-6498 -COMMA- denotes ,
T5380 6492-6497 NN denotes IL-15
T5379 6490-6491 -COMMA- denotes ,
T5378 6485-6490 NN denotes IL-18
T5377 6483-6484 -COMMA- denotes ,
T5376 6478-6483 NN denotes IL-17
T5375 6466-6477 JJ denotes Recombinant
T5503 7150-7152 NN denotes BD
T5034 6429-6437 NNP denotes Research
T5033 6423-6428 NNP denotes Human
T5032 6417-6422 NNP denotes Korea
T5031 6414-6416 IN denotes of
T5030 6403-6413 NNP denotes University
T5029 6394-6402 NNP denotes Catholic
T5028 6390-6393 DT denotes the
T5027 6387-6389 IN denotes by
T5026 6378-6386 VB denotes approved
T5025 6374-6377 VB denotes was
T5024 6365-6373 NN denotes protocol
T5023 6361-6364 DT denotes the
T5022 6357-6360 CC denotes and
T5021 6355-6356 -COMMA- denotes ,
T5020 6347-6355 VB denotes obtained
T5019 6343-6346 VB denotes was
T5018 6335-6342 NN denotes consent
T5017 6326-6334 VB denotes Informed
T5016 6323-6324 -RRB- denotes )
T5015 6318-6323 NN denotes years
T5014 6312-6317 CD denotes 24–57
T5013 6306-6311 NN denotes range
T5012 6305-6306 -LRB- denotes (
T5011 6299-6304 NN denotes years
T5010 6297-6298 CD denotes 6
T5009 6295-6296 CC denotes ±
T5008 6292-6294 CD denotes 30
T5007 6288-6291 CC denotes and
T5006 6286-6287 -RRB- denotes )
T5005 6281-6286 NN denotes years
T5004 6275-6280 CD denotes 34–68
T5003 6269-6274 NN denotes range
T5002 6268-6269 -LRB- denotes (
T5001 6262-6267 NN denotes years
T5000 6260-6261 CD denotes 8
T4999 6258-6259 CC denotes ±
T4998 6255-6257 CD denotes 50
T4997 6250-6254 VB denotes were
T4996 6241-6249 NN denotes controls
T4995 6233-6240 JJ denotes healthy
T4994 6229-6232 DT denotes the
T4993 6225-6228 CC denotes and
T4992 6222-6224 NN denotes OA
T4991 6217-6221 IN denotes with
T4990 6208-6216 NN denotes patients
T4989 6204-6207 DT denotes the
T4988 6201-6203 IN denotes of
T4987 6196-6200 NN denotes ages
T4986 6191-6195 JJ denotes mean
T4985 6187-6190 DT denotes The
T4984 6177-6185 NN denotes diseases
T4983 6167-6176 JJ denotes rheumatic
T4982 6164-6166 DT denotes no
T4981 6160-6163 VB denotes had
T4980 6156-6159 WP denotes who
T4979 6154-6155 -RRB- denotes )
T4978 6149-6154 NN denotes women
T4977 6146-6148 CD denotes 11
T4976 6142-6145 CC denotes and
T4975 6138-6141 NN denotes men
T4974 6136-6137 CD denotes 3
T4973 6135-6136 -LRB- denotes (
T4972 6126-6134 NN denotes controls
T4971 6118-6125 JJ denotes healthy
T4970 6115-6117 CD denotes 14
T4969 6110-6114 IN denotes with
T4968 6106-6109 CC denotes and
T4967 6104-6105 -RRB- denotes )
T4966 6099-6104 NN denotes women
T4965 6096-6098 CD denotes 11
T4964 6092-6095 CC denotes and
T4963 6088-6091 NN denotes men
T4962 6086-6087 CD denotes 3
T4961 6085-6086 -LRB- denotes (
T4960 6082-6084 NN denotes OA
T4959 6077-6081 IN denotes with
T4958 6068-6076 NN denotes patients
T4957 6065-6067 CD denotes 14
T4956 6060-6064 IN denotes with
T4955 6055-6059 VB denotes made
T4954 6050-6054 VB denotes were
T4953 6038-6049 NN denotes Comparisons
T4952 6031-6036 NN denotes study
T4951 6027-6030 DT denotes the
T4950 6024-6026 TO denotes to
T4949 6018-6023 NN denotes entry
T4948 6011-6017 IN denotes before
T4947 6005-6010 NN denotes hours
T4946 6002-6004 CD denotes 48
T4945 5994-6001 VB denotes stopped
T4944 5989-5993 VB denotes were
T4943 5977-5988 NN denotes medications
T4942 5973-5976 DT denotes All
T4941 5970-5971 -RRB- denotes )
T4940 5965-5970 NN denotes years
T4939 5959-5964 CD denotes 23–71
T4938 5953-5958 NN denotes range
T4937 5952-5953 -LRB- denotes (
T4936 5946-5951 NN denotes years
T4935 5944-5945 -RRB- denotes )
T4934 5941-5944 NN denotes SEM
T4933 5939-5940 CC denotes ±
T4932 5934-5938 NN denotes mean
T4931 5933-5934 -LRB- denotes (
T4930 5931-5932 CD denotes 8
T4929 5929-5930 SYM denotes ±
T4928 5926-5928 CD denotes 50
T4927 5922-5925 VB denotes was
T4926 5919-5921 NN denotes RA
T4925 5914-5918 IN denotes with
T4924 5905-5913 NN denotes patients
T4923 5901-5904 DT denotes the
T4922 5898-5900 IN denotes of
T4921 5894-5897 NN denotes age
T4920 5890-5893 DT denotes The
T4919 5887-5888 -RRB- denotes ]
T4918 5885-5887 CD denotes 17
T4917 5884-5885 -LRB- denotes [
T4916 5882-5883 -RRB- denotes )
T4915 5871-5882 NNP denotes Association
T4914 5860-5870 NNP denotes Rheumatism
T4913 5851-5859 NNP denotes American
T4912 5847-5850 DT denotes the
T4911 5838-5846 RB denotes formerly
T4910 5837-5838 -LRB- denotes (
T4909 5824-5836 NNP denotes Rheumatology
T4908 5821-5823 IN denotes of
T4907 5813-5820 NNP denotes College
T4906 5804-5812 NNP denotes American
T4905 5800-5803 DT denotes the
T4904 5797-5799 IN denotes of
T4903 5788-5796 NN denotes criteria
T4902 5780-5787 VB denotes revised
T4901 5775-5779 CD denotes 1987
T4900 5771-5774 DT denotes the
T4899 5761-5770 VB denotes fulfilled
T4898 5757-5760 WP denotes who
T4897 5754-5756 NN denotes RA
T4896 5749-5753 IN denotes with
T4895 5747-5748 -RRB- denotes )
T4894 5742-5747 NN denotes women
T4893 5739-5741 CD denotes 19
T4892 5735-5738 CC denotes and
T4891 5731-5734 NN denotes men
T4890 5729-5730 CD denotes 5
T4889 5728-5729 -LRB- denotes (
T4888 5719-5727 NN denotes patients
T4887 5716-5718 CD denotes 24
T4886 5711-5715 IN denotes from
T4885 5702-5710 VB denotes obtained
T4884 5698-5701 VB denotes was
T4883 5690-5697 NN denotes consent
T4882 5681-5689 VB denotes Informed
T4881 5672-5680 NN denotes Patients
T5036 6445-6454 NNP denotes Committee
T5035 6438-6444 NNP denotes Ethics
T3461 5644-5646 NN denotes RA
T3460 5641-5643 IN denotes in
T3459 5630-5640 NN denotes strategies
T3458 5618-5629 JJ denotes therapeutic
T3457 5614-5617 JJ denotes new
T3456 5610-5613 IN denotes for
T3455 5599-5609 NN denotes directions
T3454 5592-5598 JJ denotes future
T3453 5588-5591 CC denotes and
T3452 5585-5587 NN denotes RA
T3451 5582-5584 IN denotes of
T3450 5569-5581 NN denotes pathogenesis
T3449 5565-5568 DT denotes the
T3448 5560-5564 IN denotes into
T3447 5551-5559 NN denotes insights
T3446 5547-5550 JJ denotes new
T3445 5539-5546 VB denotes provide
T3444 5533-5538 MD denotes might
T3443 5525-5532 NN denotes results
T3442 5519-5524 DT denotes These
T3441 5515-5517 NN denotes RA
T3440 5512-5514 IN denotes in
T3439 5506-5511 NN denotes IL-17
T3438 5497-5505 NN denotes cytokine
T3437 5484-5496 JJ denotes inflammatory
T3436 5480-5483 JJ denotes key
T3435 5476-5479 DT denotes the
T3434 5473-5475 IN denotes of
T3433 5458-5472 NN denotes overproduction
T3432 5454-5457 DT denotes the
T3431 5451-5453 IN denotes in
T3430 5442-5450 VB denotes involved
T3429 5439-5441 VB denotes be
T3428 5433-5438 MD denotes might
T3427 5427-5432 NN denotes NF-κB
T3426 5423-5426 CC denotes and
T3425 5418-5422 NN denotes /Akt
T3424 5417-5418 -RRB- denotes )
T3423 5413-5417 NN denotes PI3K
T3422 5412-5413 -LRB- denotes (
T3421 5403-5411 NN denotes 3-kinase
T3420 5386-5402 NN denotes phosphoinositide
T3419 5376-5385 VB denotes involving
T3418 5368-5375 NN denotes pathway
T3417 5358-5367 NN denotes signaling
T3416 5344-5357 JJ denotes intracellular
T3415 5340-5343 DT denotes the
T3414 5335-5339 IN denotes that
T3413 5329-5334 VB denotes found
T3412 5326-5328 PRP denotes We
T3411 5317-5324 NN denotes pathway
T3410 5304-5316 NN denotes transduction
T3409 5294-5303 NN denotes signaling
T3408 5290-5293 PRP-DOLLAR- denotes its
T3407 5286-5289 CC denotes and
T3406 5283-5285 NN denotes RA
T3405 5278-5282 IN denotes with
T3404 5269-5277 NN denotes patients
T3403 5266-5268 IN denotes of
T3402 5261-5265 NN denotes PBMC
T3401 5258-5260 IN denotes in
T3400 5247-5257 NN denotes production
T3399 5241-5246 NN denotes IL-17
T3397 5226-5228 TO denotes to
T3396 5218-5225 NN denotes stimuli
T3395 5210-5217 JJ denotes various
T3394 5205-5209 VB denotes used
T3393 5202-5204 PRP denotes we
T3392 5196-5201 NN denotes study
T3391 5188-5195 JJ denotes present
T3390 5184-5187 DT denotes the
T3389 5181-5183 IN denotes In
T3388 5170-5179 JJ denotes uncertain
T3387 5162-5169 VB denotes remains
T3386 5151-5161 NN denotes production
T3385 5145-5150 NN denotes IL-17
T3384 5141-5144 IN denotes for
T3383 5133-5140 NN denotes pathway
T3382 5120-5132 NN denotes transduction
T3381 5113-5119 NN denotes signal
T3380 5099-5112 JJ denotes intracellular
T3379 5095-5098 DT denotes the
T3378 5093-5094 -COMMA- denotes ,
T3377 5092-5093 -RRB- denotes ]
T3376 5084-5092 CD denotes 12,15,16
T3375 5083-5084 -LRB- denotes [
T3374 5075-5082 NN denotes studies
T3373 5067-5074 JJ denotes earlier
T3372 5064-5066 IN denotes in
T3371 5053-5063 VB denotes documented
T3370 5048-5052 VB denotes been
T3369 5044-5047 VB denotes has
T3368 5041-5043 NN denotes RA
T3367 5038-5040 IN denotes in
T3366 5025-5037 NN denotes inflammation
T3365 5019-5024 JJ denotes joint
T3364 5016-5018 IN denotes in
T3363 5010-5015 NN denotes IL-17
T3362 5007-5009 IN denotes of
T3361 4994-5006 NN denotes contribution
T3360 4990-4993 DT denotes the
T3359 4981-4989 IN denotes Although
T3358 4978-4979 -RRB- denotes ]
T3357 4976-4978 CD denotes 14
T3356 4975-4976 -LRB- denotes [
T3355 4969-4974 NN denotes cells
T3354 4967-4968 NN denotes T
T3353 4962-4966 JJ denotes CD8+
T3352 4958-4961 CC denotes and
T3351 4953-4957 JJ denotes CD4+
T3350 4948-4952 CC denotes both
T3349 4943-4947 IN denotes from
T3348 4932-4942 NN denotes production
T3347 4926-4931 NN denotes IL-17
T3346 4923-4925 IN denotes of
T3345 4915-4922 NN denotes trigger
T3344 4905-4914 JJ denotes efficient
T3343 4902-4904 DT denotes an
T3342 4899-4901 VB denotes be
T3341 4893-4898 MD denotes could
T3340 4887-4892 NN denotes IL-23
T3339 4882-4886 IN denotes that
T3338 4875-4881 VB denotes showed
T3337 4870-4874 RB denotes also
T3336 4859-4869 NN denotes colleagues
T3335 4855-4858 CC denotes and
T3334 4848-4854 NNP denotes Happel
T3333 4846-4847 -COMMA- denotes ,
T3332 4838-4846 RB denotes Recently
T3331 4835-4836 -RRB- denotes ]
T3330 4833-4835 CD denotes 13
T3329 4832-4833 -LRB- denotes [
T3328 4823-4831 NN denotes pathways
T3327 4813-4822 JJ denotes sensitive
T3326 4805-4812 NN denotes steroid
T3325 4801-4804 CC denotes and
T3324 4788-4800 NN denotes cyclosporine
T3323 4785-4787 IN denotes by
T3322 4783-4784 -RRB- denotes )
T3321 4779-4783 NN denotes PBMC
T3320 4778-4779 -LRB- denotes (
T3319 4772-4777 NN denotes cells
T3318 4760-4771 JJ denotes mononuclear
T3317 4754-4759 NN denotes blood
T3316 4743-4753 JJ denotes peripheral
T3315 4740-4742 NN denotes RA
T3314 4737-4739 IN denotes in
T3313 4726-4736 NN denotes production
T3312 4720-4725 NN denotes IL-17
T3311 4717-4719 IN denotes of
T3310 4709-4716 NN denotes trigger
T3309 4699-4708 JJ denotes important
T3308 4696-4698 DT denotes an
T3307 4693-4695 VB denotes be
T3306 4690-4692 TO denotes to
T3305 4681-4689 VB denotes reported
T3304 4676-4680 VB denotes been
T3303 4672-4675 VB denotes has
T3302 4670-4671 -COMMA- denotes ,
T3301 4659-4670 NN denotes macrophages
T3300 4649-4658 VB denotes activated
T3299 4644-4648 IN denotes from
T3298 4635-4643 VB denotes secreted
T3297 4633-4634 -COMMA- denotes ,
T3296 4628-4633 NN denotes IL-15
T3295 4625-4626 -RRB- denotes ]
T3294 4620-4625 CD denotes 11,12
T3293 4619-4620 -LRB- denotes [
T3292 4610-4618 NN denotes synovium
T3291 4606-4609 DT denotes the
T3290 4603-4605 IN denotes in
T3289 4597-4602 NN denotes cells
T3288 4595-4596 NN denotes T
T3287 4590-4594 JJ denotes CD4+
T3286 4587-4589 IN denotes by
T3285 4578-4586 VB denotes produced
T3284 4574-4577 VB denotes was
T3283 4571-4573 PRP denotes it
T3282 4567-4570 CC denotes and
T3281 4565-4566 -COMMA- denotes ,
T3280 4564-4565 -RRB- denotes )
T3279 4562-4564 NN denotes OA
T3278 4561-4562 -LRB- denotes (
T3277 4546-4560 NN denotes osteoarthritis
T3276 4541-4545 IN denotes with
T3275 4532-4540 NN denotes patients
T3274 4529-4531 IN denotes in
T3273 4524-4528 IN denotes than
T3272 4521-4523 NN denotes RA
T3271 4516-4520 IN denotes with
T3270 4507-4515 NN denotes patients
T3269 4504-4506 IN denotes in
T3258 4436-4440 CD denotes 8-10
T3257 4435-4436 -LRB- denotes [
T3256 4429-4434 NN denotes cells
T3255 4419-4428 JJ denotes dendritic
T3254 4415-4418 DT denotes the
T3253 4406-4414 VB denotes activate
T3252 4402-4405 CC denotes and
T3251 4388-4401 VB denotes differentiate
T3250 4385-4387 TO denotes to
T3249 4377-4384 NN denotes ability
T3248 4373-4376 DT denotes the
T3247 4369-4372 VB denotes has
T3246 4365-4368 CC denotes and
T3245 4363-4364 -COMMA- denotes ,
T3244 4351-4363 NN denotes chondrocytes
T3243 4348-4350 IN denotes by
T3242 4342-4347 NN denotes oxide
T3241 4335-4341 JJ denotes nitric
T3240 4331-4334 CC denotes and
T3239 4328-4330 NN denotes E2
T3238 4314-4327 NN denotes prostaglandin
T3237 4311-4313 IN denotes of
T3236 4307-4310 CC denotes and
T3235 4305-4306 -COMMA- denotes ,
T3234 4293-4305 NN denotes synoviocytes
T3233 4290-4292 IN denotes by
T3232 4283-4289 NN denotes factor
T3231 4272-4282 JJ denotes inhibitory
T3230 4263-4271 NN denotes leukemia
T3229 4259-4262 CC denotes and
T3228 4254-4258 NN denotes IL-6
T3227 4251-4253 IN denotes of
T3226 4240-4250 NN denotes production
T3225 4236-4239 DT denotes the
T3224 4225-4235 VB denotes stimulates
T3223 4220-4224 RB denotes also
T3222 4217-4219 PRP denotes It
T3221 4214-4215 -RRB- denotes ]
T3220 4213-4214 CD denotes 7
T3219 4212-4213 -LRB- denotes [
T3218 4209-4211 NN denotes RA
T3217 4206-4208 IN denotes in
T3216 4198-4205 NN denotes erosion
T3215 4193-4197 JJ denotes bony
T3214 4190-4192 IN denotes in
T3213 4181-4189 VB denotes involved
T3212 4178-4180 VB denotes is
T3211 4172-4177 WDT denotes which
T3210 4170-4171 -COMMA- denotes ,
T3209 4169-4170 -RRB- denotes )
T3208 4163-4169 NN denotes ligand
T3207 4161-4162 -RRB- denotes ]
T3206 4156-4161 NN denotes NF-κB
T3205 4155-4156 -LRB- denotes [
T3204 4152-4154 NN denotes κB
T3203 4145-4151 NN denotes factor
T3202 4137-4144 JJ denotes nuclear
T3201 4134-4136 IN denotes of
T3200 4124-4133 NN denotes activator
T3199 4115-4123 NN denotes receptor
T3198 4114-4115 -LRB- denotes (
T3197 4108-4113 NN denotes RANKL
T3196 4105-4107 IN denotes of
T3195 4095-4104 NN denotes induction
T3194 4091-4094 DT denotes the
T3193 4088-4090 IN denotes by
T3192 4077-4087 NN denotes resorption
T3191 4072-4076 NN denotes bone
T3190 4059-4071 JJ denotes osteoclastic
T3189 4050-4058 VB denotes activate
T3188 4045-4049 RB denotes also
T3187 4041-4044 MD denotes can
T3186 4035-4040 NN denotes IL-17
T3185 4030-4034 IN denotes that
T3184 4017-4029 VB denotes demonstrated
T3183 4004-4016 NN denotes observations
T3182 3997-4003 JJ denotes Recent
T3181 3994-3995 -RRB- denotes ]
T3180 3993-3994 CD denotes 6
T3179 3992-3993 -LRB- denotes [
T3178 3986-3991 NN denotes cells
T3177 3984-3985 NN denotes T
T3176 3981-3983 IN denotes by
T3175 3972-3980 VB denotes produced
T3174 3969-3971 VB denotes is
T3173 3966-3968 PRP denotes it
T3172 3964-3965 -COMMA- denotes ,
T3171 3958-3964 RB denotes second
T3170 3956-3957 -COLON- denotes ;
T3169 3946-3956 NN denotes properties
T3168 3930-3945 JJ denotes proinflammatory
T3167 3926-3929 VB denotes has
T3166 3920-3925 NN denotes IL-17
T3165 3918-3919 -COMMA- denotes ,
T3164 3914-3918 NN denotes IL-1
T3163 3910-3913 CC denotes and
T3162 3904-3909 NN denotes TNF-α
T3161 3901-3903 TO denotes to
T3160 3891-3900 RB denotes similarly
T3159 3889-3890 -COMMA- denotes ,
T3158 3884-3889 RB denotes first
T3157 3882-3883 -COLON- denotes :
T3156 3875-3882 NN denotes reasons
T3155 3869-3874 JJ denotes major
T3154 3865-3868 CD denotes two
T3153 3861-3864 IN denotes for
T3152 3852-3860 NN denotes interest
T3151 3849-3851 IN denotes of
T3150 3846-3848 VB denotes is
T3149 3837-3845 NN denotes cytokine
T3148 3832-3836 DT denotes This
T3147 3829-3830 -RRB- denotes ]
T3146 3828-3829 CD denotes 5
T3145 3827-3828 -LRB- denotes [
T3144 3815-3826 NN denotes fibroblasts
T3143 3812-3814 IN denotes by
T3142 3807-3811 NN denotes IL-8
T3141 3803-3806 CC denotes and
T3140 3798-3802 NN denotes IL-6
T3139 3791-3797 VB denotes induce
T3138 3787-3790 MD denotes can
T3137 3781-3786 WDT denotes which
T3136 3779-3780 -COMMA- denotes ,
T3135 3774-3779 NN denotes cells
T3134 3772-3773 NN denotes T
T3133 3762-3771 VB denotes activated
T3132 3759-3761 IN denotes by
T3131 3752-3758 RB denotes mainly
T3130 3743-3751 VB denotes secreted
T3129 3733-3742 NN denotes cytokines
T3128 3720-3732 JJ denotes inflammatory
T3127 3716-3719 DT denotes the
T3126 3713-3715 IN denotes of
T3125 3709-3712 CD denotes one
T3124 3706-3708 VB denotes is
T3123 3700-3705 NN denotes IL-17
T3122 3691-3698 NN denotes aspects
T3121 3681-3690 JJ denotes different
T3120 3678-3680 IN denotes in
T3119 3667-3677 VB denotes elucidated
T3118 3664-3666 VB denotes be
T3117 3661-3663 TO denotes to
T3116 3655-3660 VB denotes needs
T3115 3649-3654 NN denotes cells
T3114 3647-3648 NN denotes T
T3113 3644-3646 IN denotes of
T3112 3639-3643 NN denotes role
T3111 3635-3638 DT denotes the
T3110 3633-3634 -COMMA- denotes ,
T3109 3632-3633 -RRB- denotes ]
T3108 3631-3632 CD denotes 4
T3107 3630-3631 -LRB- denotes [
T3106 3627-3629 NN denotes RA
T3105 3624-3626 IN denotes in
T3104 3614-3623 NN denotes cytokines
T3103 3612-3613 -RRB- denotes )
T3102 3609-3612 NN denotes Th1
T3101 3608-3609 -LRB- denotes (
T3100 3606-3607 CD denotes 1
T3099 3601-3605 NN denotes type
T3098 3594-3600 NN denotes helper
T3097 3592-3593 NN denotes T
T3096 3589-3591 IN denotes of
T3095 3581-3588 NN denotes skewing
T3094 3577-3580 DT denotes the
T3093 3573-3576 CC denotes and
T3092 3571-3572 -COMMA- denotes ,
T3091 3563-3571 NN denotes collagen
T3090 3560-3562 CD denotes II
T3089 3555-3559 NN denotes type
T3088 3552-3554 TO denotes to
T3087 3541-3551 RB denotes especially
T3086 3539-3540 -COMMA- denotes ,
T3085 3534-3539 NN denotes cells
T3084 3532-3533 NN denotes T
T3083 3523-3531 JJ denotes specific
T3082 3515-3522 NN denotes antigen
T3081 3512-3514 IN denotes of
T3080 3498-3511 NN denotes proliferation
T3079 3489-3497 VB denotes enhanced
T3078 3485-3488 DT denotes the
T3077 3472-3484 VB denotes demonstrated
T3076 3464-3471 RB denotes already
T3075 3459-3463 VB denotes have
T3074 3456-3458 PRP denotes we
T3073 3448-3455 IN denotes Because
T3072 3445-3446 -RRB- denotes ]
T3071 3444-3445 CD denotes 3
T3070 3443-3444 -LRB- denotes [
T3069 3440-3442 NN denotes RA
T3068 3437-3439 IN denotes of
T3067 3424-3436 NN denotes pathogenesis
T3066 3420-3423 DT denotes the
T3065 3417-3419 IN denotes in
T3064 3411-3416 NN denotes cells
T3063 3409-3410 NN denotes T
T3062 3406-3408 IN denotes of
T3061 3401-3405 NN denotes role
T3060 3397-3400 DT denotes the
T3059 3386-3396 VB denotes questioned
T3058 3382-3385 VB denotes has
T3057 3374-3381 NN denotes paradox
T3056 3369-3373 DT denotes This
T3055 3359-3367 NN denotes synovium
T3054 3348-3358 JJ denotes rheumatoid
T3053 3345-3347 IN denotes in
T3052 3336-3344 JJ denotes abundant
T3051 3331-3335 VB denotes were
T3050 3325-3330 NN denotes TNF-α
T3049 3321-3324 CC denotes and
T3048 3315-3320 NN denotes IL-18
T3047 3313-3314 -COMMA- denotes ,
T3046 3308-3313 NN denotes IL-15
T3045 3306-3307 -COMMA- denotes ,
T3044 3302-3306 NN denotes IL-6
T3043 3300-3301 -COMMA- denotes ,
T3022 3166-3167 NN denotes T
T3021 3163-3165 IN denotes of
T3020 3155-3162 NN denotes paucity
T3019 3142-3154 VB denotes demonstrated
T3018 3134-3141 NN denotes studies
T3017 3131-3133 IN denotes of
T3016 3124-3130 NN denotes series
T3015 3122-3123 DT denotes a
T3014 3120-3121 -COMMA- denotes ,
T3013 3113-3120 RB denotes However
T3012 3103-3111 NN denotes synovium
T3011 3099-3102 DT denotes the
T3010 3086-3098 VB denotes infiltrating
T3009 3075-3085 NN denotes population
T3008 3070-3074 NN denotes cell
T3007 3062-3069 JJ denotes largest
T3006 3058-3061 DT denotes the
T3005 3054-3057 VB denotes are
T3004 3049-3053 PRP denotes they
T3003 3041-3048 IN denotes because
T3002 3030-3040 JJ denotes undisputed
T3001 3026-3029 VB denotes was
T3000 3023-3025 NN denotes RA
T2999 3020-3022 IN denotes as
T2998 3015-3019 JJ denotes such
T2997 3007-3014 NN denotes disease
T2996 2996-3006 JJ denotes autoimmune
T2995 2993-2995 IN denotes of
T2994 2980-2992 NN denotes pathogenesis
T2993 2976-2979 DT denotes the
T2992 2973-2975 IN denotes in
T2991 2967-2972 NN denotes cells
T2990 2965-2966 NN denotes T
T2989 2962-2964 IN denotes of
T2988 2954-2961 NN denotes primacy
T2987 2950-2953 DT denotes the
T2986 2948-2949 -COMMA- denotes ,
T2985 2945-2948 RB denotes ago
T2984 2938-2944 NN denotes decade
T2983 2936-2937 DT denotes a
T2982 2931-2935 IN denotes over
T2981 2924-2930 JJ denotes little
T2980 2922-2923 DT denotes A
T2979 2919-2920 -RRB- denotes ]
T2978 2918-2919 CD denotes 2
T2977 2917-2918 -LRB- denotes [
T2976 2904-2916 NN denotes applications
T2975 2892-2903 JJ denotes therapeutic
T2974 2888-2891 JJ denotes new
T3268 4497-4503 JJ denotes higher
T3267 4483-4496 RB denotes significantly
T3266 4478-4482 VB denotes were
T3265 4471-4477 NN denotes fluids
T3264 4462-4470 JJ denotes synovial
T3263 4459-4461 IN denotes in
T3262 4453-4458 NN denotes IL-17
T3261 4450-4452 IN denotes of
T3260 4443-4449 NN denotes Levels
T3259 4440-4441 -RRB- denotes ]
T2973 2885-2887 IN denotes of
T2972 2873-2884 NN denotes development
T2971 2869-2872 DT denotes the
T2970 2866-2868 IN denotes in
T2969 2860-2865 NN denotes issue
T2968 2850-2859 JJ denotes important
T2967 2846-2849 DT denotes the
T2966 2841-2845 VB denotes been
T2965 2837-2840 VB denotes has
T2964 2827-2836 NN denotes cytokines
T2963 2814-2826 JJ denotes inflammatory
T2962 2810-2813 JJ denotes key
T2961 2807-2809 IN denotes of
T2960 2798-2806 NN denotes blockade
T2959 2794-2797 DT denotes the
T2958 2789-2793 IN denotes that
T2957 2781-2788 VB denotes suggest
T2956 2778-2780 CD denotes -1
T2955 2777-2778 -RRB- denotes )
T2954 2775-2777 NN denotes IL
T2953 2774-2775 -LRB- denotes (
T2952 2762-2773 NN denotes interleukin
T2951 2758-2761 CC denotes and
T2950 2756-2757 -RRB- denotes )
T2949 2754-2756 NN denotes -α
T2948 2753-2754 -RRB- denotes )
T2947 2750-2753 NN denotes TNF
T2946 2749-2750 -LRB- denotes (
T2945 2742-2748 NN denotes factor
T2944 2733-2741 NN denotes necrosis
T2943 2727-2732 NN denotes tumor
T2942 2724-2726 IN denotes of
T2941 2713-2723 NN denotes inhibitors
T2940 2708-2712 IN denotes with
T2939 2699-2707 VB denotes obtained
T2938 2690-2698 NN denotes benefits
T2937 2681-2689 JJ denotes clinical
T2936 2671-2680 JJ denotes favorable
T2935 2667-2670 DT denotes The
T2934 2664-2665 -RRB- denotes ]
T2933 2663-2664 CD denotes 1
T2932 2662-2663 -LRB- denotes [
T2931 2659-2661 NN denotes RA
T2930 2656-2658 IN denotes in
T2929 2649-2655 NN denotes joints
T2928 2646-2648 IN denotes of
T2927 2634-2645 NN denotes destruction
T2926 2630-2633 DT denotes the
T2925 2627-2629 IN denotes in
T2924 2617-2626 JJ denotes important
T2923 2614-2616 VB denotes be
T2922 2611-2613 TO denotes to
T2921 2605-2610 VB denotes known
T2920 2601-2604 VB denotes are
T2919 2595-2600 NN denotes cells
T2918 2589-2594 DT denotes these
T2917 2584-2588 IN denotes from
T2916 2575-2583 VB denotes released
T2915 2565-2574 NN denotes cytokines
T2914 2549-2564 JJ denotes Proinflammatory
T2913 2536-2547 NN denotes hyperplasia
T2912 2527-2535 JJ denotes synovial
T2911 2523-2526 CC denotes and
T2910 2521-2522 -COMMA- denotes ,
T2909 2516-2521 NN denotes joint
T2908 2512-2515 DT denotes the
T2907 2507-2511 IN denotes into
T2906 2501-2506 NN denotes cells
T2905 2499-2500 NN denotes T
T2904 2495-2498 CC denotes and
T2903 2483-2494 NN denotes macrophages
T2902 2480-2482 IN denotes of
T2901 2466-2479 NN denotes infiltrations
T2900 2463-2465 IN denotes by
T2899 2449-2462 VB denotes characterized
T2898 2446-2448 VB denotes is
T2897 2444-2445 -RRB- denotes )
T2896 2442-2444 NN denotes RA
T2895 2441-2442 -LRB- denotes (
T2894 2431-2440 NN denotes arthritis
T2893 2420-2430 JJ denotes Rheumatoid
T3042 3296-3300 NN denotes IL-1
T3041 3286-3295 VB denotes including
T3040 3276-3285 NN denotes cytokines
T3039 3265-3275 NN denotes fibroblast
T3038 3261-3264 CC denotes and
T3037 3250-3260 NN denotes macrophage
T3036 3242-3249 IN denotes whereas
T3035 3240-3241 -COMMA- denotes ,
T3034 3238-3240 NN denotes RA
T3033 3235-3237 IN denotes of
T3032 3228-3234 NN denotes joints
T3031 3224-3227 DT denotes the
T3030 3221-3223 IN denotes in
T3029 3208-3220 NN denotes interferon-γ
T3028 3204-3207 CC denotes and
T3027 3199-3203 NN denotes IL-2
T3026 3196-3198 IN denotes as
T3025 3191-3195 JJ denotes such
T3024 3181-3190 NN denotes cytokines
T3023 3168-3180 JJ denotes cell-derived
T1027 2402-2404 NN denotes RA
T1026 2399-2401 IN denotes in
T1025 2393-2398 NN denotes IL-17
T1024 2384-2392 NN denotes cytokine
T1023 2371-2383 JJ denotes inflammatory
T1022 2367-2370 JJ denotes key
T1021 2363-2366 DT denotes the
T1020 2360-2362 IN denotes of
T1019 2345-2359 NN denotes overproduction
T1018 2341-2344 DT denotes the
T1017 2338-2340 IN denotes in
T1016 2329-2337 VB denotes involved
T1015 2325-2328 VB denotes are
T1014 2319-2324 NN denotes NF-κB
T1013 2315-2318 CC denotes and
T1012 2306-2314 NN denotes PI3K/Akt
T1011 2303-2305 IN denotes on
T1010 2293-2302 JJ denotes dependent
T1009 2284-2292 NN denotes pathways
T1008 2271-2283 NN denotes transduction
T1007 2264-2270 NN denotes signal
T1006 2259-2263 IN denotes that
T1005 2251-2258 VB denotes suggest
T1004 2243-2250 NN denotes results
T1003 2237-2242 DT denotes These
T1002 2225-2235 NN denotes production
T1001 2219-2224 NN denotes IL-17
T1000 2212-2218 VB denotes affect
T999 2208-2211 RB denotes not
T998 2204-2207 VB denotes did
T997 2200-2203 CD denotes 1/2
T996 2193-2199 NN denotes kinase
T995 2176-2192 JJ denotes signal-regulated
T994 2162-2175 JJ denotes extracellular
T993 2158-2161 CC denotes and
T992 2148-2157 NN denotes protein-1
T991 2138-2147 NN denotes activator
T990 2135-2137 IN denotes of
T989 2124-2134 NN denotes inhibition
T988 2122-2123 -COMMA- denotes ,
T987 2115-2122 RB denotes However
T986 2101-2113 RB denotes respectively
T985 2099-2100 -COMMA- denotes ,
T984 2091-2099 NN denotes LY294002
T983 2087-2090 CC denotes and
T982 2076-2086 NN denotes wortmannin
T981 2066-2075 NN denotes inhibitor
T980 2057-2065 NN denotes PI3K/Akt
T979 2053-2056 DT denotes the
T978 2049-2052 CC denotes and
T977 2033-2048 NN denotes dithiocarbamate
T976 2021-2032 NN denotes pyrrolidine
T975 2011-2020 NN denotes inhibitor
T974 2005-2010 NN denotes NF-κB
T973 2001-2004 DT denotes the
T972 1998-2000 IN denotes of
T971 1989-1997 NN denotes presence
T970 1985-1988 DT denotes the
T969 1982-1984 IN denotes in
T968 1974-1981 VB denotes blocked
T967 1967-1973 RB denotes partly
T966 1964-1966 CC denotes or
T965 1953-1963 RB denotes completely
T964 1950-1952 VB denotes is
T963 1945-1949 NN denotes PBMC
T962 1942-1944 NN denotes RA
T961 1932-1941 VB denotes activated
T960 1929-1931 IN denotes by
T959 1918-1928 NN denotes production
T958 1912-1917 NN denotes IL-17
T957 1902-1910 NN denotes activity
T956 1890-1901 JJ denotes DNA-binding
T955 1888-1889 -RRB- denotes )
T954 1883-1888 NN denotes NF-κB
T953 1882-1883 -LRB- denotes (
T952 1879-1881 NN denotes κB
T951 1872-1878 NN denotes factor
T950 1864-1871 JJ denotes nuclear
T949 1861-1863 IN denotes of
T948 1848-1860 NN denotes augmentation
T947 1837-1847 JJ denotes pronounced
T946 1835-1836 DT denotes a
T945 1832-1834 IN denotes in
T944 1823-1831 VB denotes resulted
T943 1815-1822 NN denotes pathway
T942 1810-1814 DT denotes this
T941 1807-1809 IN denotes of
T940 1796-1806 NN denotes activation
T939 1794-1795 -COLON- denotes ;
T938 1787-1794 NN denotes pathway
T937 1778-1786 NN denotes PI3K/Akt
T936 1774-1777 DT denotes the
T935 1764-1773 VB denotes activated
T934 1755-1763 NN denotes antibody
T933 1746-1754 JJ denotes Anti-CD3
T932 1740-1744 NN denotes PBMC
T931 1737-1739 NN denotes RA
T930 1734-1736 IN denotes of
T929 1728-1733 DT denotes those
T928 1723-1727 IN denotes than
T927 1717-1722 JJ denotes lower
T926 1712-1716 RB denotes much
T925 1707-1711 VB denotes were
T924 1700-1706 NN denotes levels
T923 1689-1699 NN denotes expression
T922 1683-1688 PRP-DOLLAR- denotes their
T921 1679-1682 CC denotes but
T920 1677-1678 -COMMA- denotes ,
T919 1663-1677 NN denotes osteoarthritis
T918 1658-1662 IN denotes with
T917 1649-1657 NN denotes patients
T916 1646-1648 IN denotes of
T915 1641-1645 NN denotes PBMC
T914 1637-1640 DT denotes the
T913 1634-1636 IN denotes in
T912 1625-1633 VB denotes detected
T911 1620-1624 RB denotes also
T910 1616-1619 VB denotes was
T909 1610-1615 NN denotes IL-17
T908 1605-1608 RB denotes not
T907 1601-1604 VB denotes did
T906 1592-1600 NN denotes factor-β
T905 1585-1591 NN denotes growth
T904 1572-1584 VB denotes transforming
T903 1569-1571 CC denotes or
T902 1563-1568 NN denotes IL-18
T901 1561-1562 -COMMA- denotes ,
T900 1556-1561 NN denotes IL-1β
T899 1554-1555 -COMMA- denotes ,
T898 1546-1554 NN denotes factor-α
T897 1537-1545 NN denotes necrosis
T896 1531-1536 NN denotes tumor
T895 1523-1530 IN denotes whereas
T894 1521-1522 -COMMA- denotes ,
T893 1520-1521 -RRB- denotes )
T892 1516-1520 CD denotes 0.05
T891 1514-1515 SYM denotes <
T890 1512-1513 NN denotes P
T889 1511-1512 -LRB- denotes (
T888 1500-1510 NN denotes production
T887 1494-1499 NN denotes IL-17
T886 1482-1493 VB denotes upregulated
T885 1477-1481 NN denotes IL-6
T884 1473-1476 CC denotes and
T883 1463-1472 NN denotes protein-1
T882 1447-1462 NN denotes chemoattractant
T881 1438-1446 NN denotes monocyte
T880 1436-1437 -COMMA- denotes ,
T879 1431-1436 NN denotes IL-15
T878 1429-1430 -COMMA- denotes ,
T877 1419-1429 NN denotes chemokines
T876 1415-1418 CC denotes and
T875 1405-1414 NN denotes cytokines
T874 1398-1404 VB denotes tested
T873 1392-1397 IN denotes Among
T872 1389-1390 -RRB- denotes )
T871 1385-1389 CD denotes 0.05
T870 1383-1384 SYM denotes <
T869 1381-1382 NN denotes P
T868 1380-1381 -LRB- denotes (
T867 1376-1379 NN denotes PHA
T866 1372-1375 CC denotes and
T865 1362-1371 NN denotes anti-CD28
T864 1354-1361 IN denotes without
T863 1351-1353 CC denotes or
T862 1346-1350 IN denotes with
T861 1337-1345 NN denotes antibody
T860 1328-1336 JJ denotes anti-CD3
T859 1323-1327 IN denotes with
T858 1315-1322 VB denotes treated
T857 1309-1314 NN denotes cells
T856 1306-1308 IN denotes in
T855 1296-1305 VB denotes increased
T854 1282-1295 RB denotes significantly
T853 1278-1281 VB denotes was
T852 1272-1277 NN denotes IL-17
T851 1269-1271 IN denotes of
T850 1258-1268 NN denotes production
T849 1254-1257 DT denotes The
T848 1244-1252 NN denotes reaction
T847 1238-1243 NN denotes chain
T846 1213-1237 NN denotes transcription–polymerase
T845 1205-1212 JJ denotes reverse
T844 1201-1204 CC denotes and
T843 1195-1200 NN denotes assay
T842 1181-1194 JJ denotes immunosorbent
T841 1167-1180 JJ denotes enzyme-linked
T840 1158-1166 JJ denotes sandwich
T839 1155-1157 IN denotes by
T838 1144-1154 VB denotes determined
T837 1139-1143 VB denotes were
T836 1132-1138 NN denotes levels
T835 1126-1131 NN denotes IL-17
T834 1114-1124 NN denotes chemokines
T833 1110-1113 CC denotes and
T832 1100-1109 NN denotes cytokines
T831 1087-1099 JJ denotes inflammatory
T830 1079-1086 JJ denotes several
T829 1075-1078 CC denotes and
T828 1073-1074 -RRB- denotes )
T827 1070-1073 NN denotes PHA
T826 1069-1070 -LRB- denotes (
T825 1050-1068 NN denotes phytohemagglutinin
T824 1048-1049 -COMMA- denotes ,
T823 1039-1048 NN denotes anti-CD28
T822 1037-1038 -COMMA- denotes ,
T821 1029-1037 NN denotes anti-CD3
T820 1019-1028 VB denotes including
T819 1012-1018 NN denotes agents
T818 1004-1011 JJ denotes various
T817 999-1003 IN denotes with
T816 988-998 VB denotes stimulated
T815 983-987 RB denotes then
T814 981-982 -COMMA- denotes ,
T813 972-981 VB denotes separated
T812 967-971 VB denotes were
T811 965-966 -RRB- denotes )
T810 963-965 CD denotes 24
T809 961-962 SYM denotes =
T808 959-960 NN denotes n
T807 958-959 -LRB- denotes (
T806 955-957 NN denotes RA
T805 950-954 IN denotes with
T804 941-949 NN denotes patients
T803 936-940 IN denotes from
T763 694-702 NN denotes pathways
T762 684-693 NN denotes signaling
T761 670-683 JJ denotes intracellular
T760 666-669 DT denotes the
T759 664-665 -COMMA- denotes ,
T758 654-664 NN denotes production
T757 648-653 NN denotes IL-17
T756 639-647 VB denotes regulate
T755 636-638 TO denotes to
T754 627-635 VB denotes reported
T753 622-626 VB denotes been
T752 617-621 VB denotes have
T751 615-616 -RRB- denotes )
T750 610-615 NN denotes IL-23
T749 606-609 CC denotes and
T748 600-605 NN denotes IL-15
T747 599-600 -LRB- denotes (
T746 589-598 NN denotes cytokines
T745 584-588 DT denotes some
T744 575-583 IN denotes Although
T743 571-573 NN denotes RA
T742 568-570 IN denotes of
T741 561-567 NN denotes models
T740 554-560 NN denotes animal
T739 551-553 IN denotes in
T738 547-550 CC denotes and
T737 538-546 NN denotes synovium
T736 535-537 NN denotes RA
T735 532-534 IN denotes in
T734 519-531 VB denotes demonstrated
T733 514-518 VB denotes been
T732 510-513 VB denotes has
T731 504-509 NN denotes IL-17
T730 501-503 IN denotes of
T729 492-500 NN denotes activity
T728 476-491 JJ denotes proinflammatory
T727 472-475 CC denotes and
T726 461-471 NN denotes expression
T725 457-460 DT denotes the
T724 453-456 IN denotes for
T723 444-452 NN denotes Evidence
T722 432-442 NN denotes resorption
T721 427-431 NN denotes bone
T720 414-426 JJ denotes osteoclastic
T719 410-413 CC denotes and
T718 400-409 NN denotes cytokines
T717 384-399 JJ denotes proinflammatory
T716 381-383 IN denotes of
T715 371-380 NN denotes induction
T714 367-370 DT denotes the
T713 357-366 VB denotes including
T712 355-356 -COMMA- denotes ,
T711 346-355 NN denotes responses
T710 333-345 JJ denotes inflammatory
T709 329-332 CC denotes and
T708 322-328 JJ denotes immune
T707 319-321 IN denotes of
T706 309-318 NN denotes regulator
T705 299-308 JJ denotes important
T704 296-298 DT denotes an
T703 293-295 VB denotes is
T702 289-292 CD denotes -17
T701 288-289 -RRB- denotes )
T700 286-288 NN denotes IL
T699 285-286 -LRB- denotes (
T698 273-284 NN denotes Interleukin
T697 270-271 -RRB- denotes )
T696 268-270 NN denotes RA
T695 267-268 -LRB- denotes (
T694 257-266 NN denotes arthritis
T693 246-256 JJ denotes rheumatoid
T692 243-245 IN denotes of
T691 230-242 NN denotes pathogenesis
T690 226-229 DT denotes the
T689 223-225 IN denotes in
T688 213-222 JJ denotes important
T687 207-212 VB denotes being
T686 204-206 IN denotes as
T685 193-203 VB denotes recognized
T684 188-192 VB denotes been
T683 183-187 VB denotes have
T682 173-182 NN denotes mediators
T681 160-172 JJ denotes Inflammatory
T802 934-935 -RRB- denotes )
T801 930-934 NN denotes PBMC
T800 929-930 -LRB- denotes (
T799 923-928 NN denotes cells
T798 911-922 JJ denotes mononuclear
T797 905-910 NN denotes blood
T796 894-904 JJ denotes Peripheral
T795 890-892 NN denotes RA
T794 887-889 IN denotes in
T793 876-886 NN denotes production
T792 870-875 NN denotes IL-17
T791 867-869 IN denotes of
T790 856-866 NN denotes regulation
T789 852-855 DT denotes the
T788 849-851 IN denotes in
T787 841-848 NN denotes pathway
T786 836-840 NN denotes /Akt
T785 835-836 -RRB- denotes )
T784 831-835 NN denotes PI3K
T783 830-831 -LRB- denotes (
T782 821-829 NN denotes 3-kinase
T781 804-820 NN denotes phosphoinositide
T780 800-803 DT denotes the
T779 797-799 IN denotes of
T778 792-796 NN denotes role
T777 788-791 DT denotes the
T776 775-787 VB denotes investigated
T775 772-774 PRP denotes we
T774 770-771 -COMMA- denotes ,
T773 765-770 NN denotes study
T772 757-764 JJ denotes present
T771 753-756 DT denotes the
T770 750-752 IN denotes In
T769 741-748 JJ denotes unknown
T768 734-740 VB denotes remain
T767 723-733 NN denotes production
T766 717-722 NN denotes IL-17
T765 708-716 VB denotes regulate
T764 703-707 WDT denotes that
T22230 28118-28119 DT denotes a
T22229 28109-28117 VB denotes detected
T22228 28104-28108 VB denotes have
T22227 28101-28103 PRP denotes We
T5374 6457-6465 NN denotes Reagents
T3398 5229-5240 VB denotes investigate
R108 T666 T664 arg2Of production,Increased
R109 T666 T665 arg1Of production,interleukin-17
R110 T666 T667 arg1Of production,via
R111 T666 T671 arg1Of production,and
R112 T670 T667 arg2Of 3-kinase/Akt,via
R113 T670 T668 arg1Of 3-kinase/Akt,a
R114 T670 T669 arg1Of 3-kinase/Akt,phosphoinositide
R115 T671 T676 arg1Of and,ay
R116 T675 T671 arg2Of t pathw,and
R117 T675 T672 arg1Of t pathw,nuclear
R118 T675 T673 arg1Of t pathw,factor
R119 T675 T674 arg1Of t pathw,κB-dependen
R120 T677 T676 arg2Of in patie,ay
R121 T677 T678 arg1Of in patie,nts
R122 T680 T678 arg2Of atoid art,nts
R123 T680 T679 arg1Of atoid art,with rheum
R124 T682 T681 arg1Of mediators,Inflammatory
R125 T682 T683 arg1Of mediators,have
R126 T682 T684 arg1Of mediators,been
R127 T682 T685 arg2Of mediators,recognized
R128 T685 T683 arg2Of recognized,have
R129 T685 T684 arg2Of recognized,been
R130 T685 T686 arg1Of recognized,as
R131 T687 T686 arg2Of being,as
R132 T687 T689 arg1Of being,in
R133 T688 T687 arg2Of important,being
R134 T691 T689 arg2Of pathogenesis,in
R135 T691 T690 arg1Of pathogenesis,the
R136 T691 T692 arg1Of pathogenesis,of
R137 T694 T692 arg2Of arthritis,of
R138 T694 T693 arg1Of arthritis,rheumatoid
R139 T694 T695 arg1Of arthritis,(
R140 T696 T695 arg2Of RA,(
R141 T697 T695 arg3Of ),(
R142 T698 T699 arg1Of Interleukin,(
R143 T698 T702 arg1Of Interleukin,-17
R144 T698 T703 arg1Of Interleukin,is
R145 T700 T699 arg2Of IL,(
R146 T701 T699 arg3Of ),(
R147 T706 T703 arg2Of regulator,is
R148 T706 T704 arg1Of regulator,an
R149 T706 T705 arg1Of regulator,important
R150 T706 T707 arg1Of regulator,of
R151 T708 T709 arg1Of immune,and
R152 T710 T709 arg2Of inflammatory,and
R153 T711 T707 arg2Of responses,of
R154 T711 T708 arg1Of responses,immune
R155 T711 T710 arg1Of responses,inflammatory
R156 T711 T712 arg1Of responses,","
R157 T711 T713 arg1Of responses,including
R158 T715 T713 arg2Of induction,including
R159 T715 T714 arg1Of induction,the
R160 T715 T716 arg1Of induction,of
R161 T718 T717 arg1Of cytokines,proinflammatory
R162 T718 T719 arg1Of cytokines,and
R163 T719 T716 arg2Of and,of
R164 T722 T719 arg2Of resorption,and
R165 T722 T720 arg1Of resorption,osteoclastic
R166 T722 T721 arg1Of resorption,bone
R167 T723 T724 arg1Of Evidence,for
R168 T723 T727 arg1Of Evidence,and
R169 T726 T724 arg2Of expression,for
R170 T726 T725 arg1Of expression,the
R171 T727 T732 arg1Of and,has
R172 T727 T733 arg1Of and,been
R173 T727 T734 arg2Of and,demonstrated
R174 T729 T727 arg2Of activity,and
R175 T729 T728 arg1Of activity,proinflammatory
R176 T729 T730 arg1Of activity,of
R177 T731 T730 arg2Of IL-17,of
R178 T734 T732 arg2Of demonstrated,has
R179 T734 T733 arg2Of demonstrated,been
R180 T734 T735 arg1Of demonstrated,in
R181 T734 T739 arg1Of demonstrated,in
R182 T735 T738 arg1Of in,and
R183 T737 T735 arg2Of synovium,in
R184 T737 T736 arg1Of synovium,RA
R185 T739 T738 arg2Of in,and
R186 T741 T739 arg2Of models,in
R187 T741 T740 arg1Of models,animal
R188 T741 T742 arg1Of models,of
R189 T743 T742 arg2Of RA,of
R190 T746 T745 arg1Of cytokines,some
R191 T746 T747 arg1Of cytokines,(
R192 T746 T752 arg1Of cytokines,have
R193 T746 T753 arg1Of cytokines,been
R194 T746 T754 arg2Of cytokines,reported
R195 T746 T756 arg1Of cytokines,regulate
R196 T748 T749 arg1Of IL-15,and
R197 T749 T747 arg2Of and,(
R198 T750 T749 arg2Of IL-23,and
R199 T751 T747 arg3Of ),(
R200 T754 T744 arg2Of reported,Although
R201 T754 T752 arg2Of reported,have
R202 T754 T753 arg2Of reported,been
R203 T756 T754 arg3Of regulate,reported
R204 T756 T755 arg1Of regulate,to
R205 T758 T756 arg2Of production,regulate
R206 T758 T757 arg1Of production,IL-17
R207 T763 T760 arg1Of pathways,the
R208 T763 T761 arg1Of pathways,intracellular
R209 T763 T762 arg1Of pathways,signaling
R210 T763 T764 arg1Of pathways,that
R211 T763 T765 arg1Of pathways,regulate
R212 T763 T768 arg1Of pathways,remain
R213 T763 T769 arg1Of pathways,unknown
R214 T767 T765 arg2Of production,regulate
R215 T767 T766 arg1Of production,IL-17
R216 T768 T744 arg1Of remain,Although
R217 T768 T759 arg1Of remain,","
R218 T769 T768 arg2Of unknown,remain
R219 T773 T770 arg2Of study,In
R220 T773 T771 arg1Of study,the
R221 T773 T772 arg1Of study,present
R222 T775 T776 arg1Of we,investigated
R223 T776 T770 arg1Of investigated,In
R224 T776 T774 arg1Of investigated,","
R225 T778 T776 arg2Of role,investigated
R226 T778 T777 arg1Of role,the
R227 T778 T779 arg1Of role,of
R228 T778 T788 arg1Of role,in
R229 T784 T783 arg2Of PI3K,(
R230 T785 T783 arg3Of ),(
R231 T787 T779 arg2Of pathway,of
R232 T787 T780 arg1Of pathway,the
R233 T787 T781 arg1Of pathway,phosphoinositide
R234 T787 T782 arg1Of pathway,3-kinase
R235 T787 T783 arg1Of pathway,(
R236 T787 T786 arg1Of pathway,/Akt
R237 T790 T788 arg2Of regulation,in
R238 T790 T789 arg1Of regulation,the
R239 T790 T791 arg1Of regulation,of
R240 T793 T791 arg2Of production,of
R241 T793 T792 arg1Of production,IL-17
R242 T793 T794 arg1Of production,in
R243 T795 T794 arg2Of RA,in
R244 T799 T796 arg1Of cells,Peripheral
R245 T799 T797 arg1Of cells,blood
R246 T799 T798 arg1Of cells,mononuclear
R247 T799 T800 arg1Of cells,(
R248 T799 T803 arg1Of cells,from
R249 T799 T812 arg1Of cells,were
R250 T799 T813 arg2Of cells,separated
R251 T799 T816 arg2Of cells,stimulated
R252 T801 T800 arg2Of PBMC,(
R253 T802 T800 arg3Of ),(
R254 T804 T803 arg2Of patients,from
R255 T804 T805 arg1Of patients,with
R256 T806 T805 arg2Of RA,with
R257 T806 T807 arg1Of RA,(
R258 T808 T807 arg2Of n,(
R259 T808 T809 arg1Of n,=
R260 T809 T810 arg1Of =,24
R261 T811 T807 arg3Of ),(
R262 T813 T814 arg1Of separated,","
R263 T814 T812 arg2Of ",",were
R264 T816 T814 arg2Of stimulated,","
R265 T816 T815 arg1Of stimulated,then
R266 T816 T817 arg1Of stimulated,with
R267 T819 T817 arg2Of agents,with
R268 T819 T818 arg1Of agents,various
R269 T819 T820 arg1Of agents,including
R270 T821 T822 arg1Of anti-CD3,","
R271 T822 T824 arg1Of ",",","
R272 T823 T822 arg2Of anti-CD28,","
R273 T824 T829 arg1Of ",",and
R274 T825 T824 arg2Of phytohemagglutinin,","
R275 T825 T826 arg1Of phytohemagglutinin,(
R276 T827 T826 arg2Of PHA,(
R277 T828 T826 arg3Of ),(
R278 T829 T833 arg1Of and,and
R279 T832 T829 arg2Of cytokines,and
R280 T832 T830 arg1Of cytokines,several
R281 T832 T831 arg1Of cytokines,inflammatory
R282 T833 T820 arg2Of and,including
R283 T834 T833 arg2Of chemokines,and
R284 T836 T835 arg1Of levels,IL-17
R285 T836 T837 arg1Of levels,were
R286 T836 T838 arg2Of levels,determined
R287 T838 T837 arg2Of determined,were
R288 T843 T840 arg1Of assay,sandwich
R289 T843 T841 arg1Of assay,enzyme-linked
R290 T843 T842 arg1Of assay,immunosorbent
R291 T843 T844 arg1Of assay,and
R292 T844 T838 arg1Of and,determined
R293 T844 T839 arg2Of and,by
R294 T848 T844 arg2Of reaction,and
R295 T848 T845 arg1Of reaction,reverse
R296 T848 T846 arg1Of reaction,transcription–polymerase
R297 T848 T847 arg1Of reaction,chain
R298 T850 T849 arg1Of production,The
R299 T850 T851 arg1Of production,of
R300 T850 T853 arg1Of production,was
R301 T850 T855 arg2Of production,increased
R302 T852 T851 arg2Of IL-17,of
R303 T855 T853 arg2Of increased,was
R304 T855 T854 arg1Of increased,significantly
R305 T855 T856 arg1Of increased,in
R306 T857 T856 arg2Of cells,in
R307 T857 T858 arg2Of cells,treated
R308 T858 T859 arg1Of treated,with
R309 T861 T859 arg2Of antibody,with
R310 T861 T860 arg1Of antibody,anti-CD3
R311 T861 T862 arg1Of antibody,with
R312 T861 T864 arg1Of antibody,without
R313 T862 T863 arg1Of with,or
R314 T864 T863 arg2Of without,or
R315 T865 T866 arg1Of anti-CD28,and
R316 T866 T862 arg2Of and,with
R317 T866 T864 arg2Of and,without
R318 T866 T868 arg1Of and,(
R319 T867 T866 arg2Of PHA,and
R320 T869 T868 arg2Of P,(
R321 T869 T870 arg1Of P,<
R322 T869 T871 arg1Of P,0.05
R323 T872 T868 arg3Of ),(
R324 T875 T876 arg1Of cytokines,and
R325 T876 T873 arg2Of and,Among
R326 T876 T874 arg2Of and,tested
R327 T877 T876 arg2Of chemokines,and
R328 T879 T880 arg1Of IL-15,","
R329 T880 T884 arg1Of ",",and
R330 T883 T880 arg2Of protein-1,","
R331 T883 T881 arg1Of protein-1,monocyte
R332 T883 T882 arg1Of protein-1,chemoattractant
R333 T884 T886 arg1Of and,upregulated
R334 T885 T884 arg2Of IL-6,and
R335 T886 T873 arg1Of upregulated,Among
R336 T886 T878 arg1Of upregulated,","
R337 T886 T894 arg1Of upregulated,","
R338 T886 T895 arg1Of upregulated,whereas
R339 T888 T886 arg2Of production,upregulated
R340 T888 T887 arg1Of production,IL-17
R341 T888 T889 arg1Of production,(
R342 T890 T889 arg2Of P,(
R343 T890 T891 arg1Of P,<
R344 T890 T892 arg1Of P,0.05
R345 T893 T889 arg3Of ),(
R346 T898 T896 arg1Of factor-α,tumor
R347 T898 T897 arg1Of factor-α,necrosis
R348 T898 T899 arg1Of factor-α,","
R349 T899 T901 arg1Of ",",","
R350 T900 T899 arg2Of IL-1β,","
R351 T901 T903 arg1Of ",",or
R352 T902 T901 arg2Of IL-18,","
R353 T903 T907 arg1Of or,did
R354 T906 T903 arg2Of factor-β,or
R355 T906 T904 arg1Of factor-β,transforming
R356 T906 T905 arg1Of factor-β,growth
R357 T907 T895 arg2Of did,whereas
R358 T907 T908 arg1Of did,not
R359 T909 T910 arg1Of IL-17,was
R360 T909 T912 arg2Of IL-17,detected
R361 T912 T910 arg2Of detected,was
R362 T912 T911 arg1Of detected,also
R363 T912 T913 arg1Of detected,in
R364 T912 T921 arg1Of detected,but
R365 T915 T913 arg2Of PBMC,in
R366 T915 T914 arg1Of PBMC,the
R367 T915 T916 arg1Of PBMC,of
R368 T917 T916 arg2Of patients,of
R369 T917 T918 arg1Of patients,with
R370 T919 T918 arg2Of osteoarthritis,with
R371 T921 T920 arg1Of but,","
R372 T924 T922 arg1Of levels,their
R373 T924 T923 arg1Of levels,expression
R374 T924 T925 arg1Of levels,were
R375 T924 T927 arg1Of levels,lower
R376 T925 T921 arg2Of were,but
R377 T927 T925 arg2Of lower,were
R378 T927 T926 arg1Of lower,much
R379 T927 T928 arg1Of lower,than
R380 T929 T928 arg2Of those,than
R381 T929 T930 arg1Of those,of
R382 T932 T930 arg2Of PBMC,of
R383 T932 T931 arg1Of PBMC,RA
R384 T934 T933 arg1Of antibody,Anti-CD3
R385 T934 T935 arg1Of antibody,activated
R386 T935 T939 arg1Of activated,;
R387 T938 T935 arg2Of pathway,activated
R388 T938 T936 arg1Of pathway,the
R389 T938 T937 arg1Of pathway,PI3K/Akt
R390 T940 T941 arg1Of activation,of
R391 T940 T944 arg1Of activation,resulted
R392 T943 T941 arg2Of pathway,of
R393 T943 T942 arg1Of pathway,this
R394 T944 T939 arg2Of resulted,;
R395 T944 T945 arg1Of resulted,in
R396 T948 T945 arg2Of augmentation,in
R397 T948 T946 arg1Of augmentation,a
R398 T948 T947 arg1Of augmentation,pronounced
R399 T948 T949 arg1Of augmentation,of
R400 T954 T953 arg2Of NF-κB,(
R401 T955 T953 arg3Of ),(
R402 T957 T949 arg2Of activity,of
R403 T957 T950 arg1Of activity,nuclear
R404 T957 T951 arg1Of activity,factor
R405 T957 T952 arg1Of activity,κB
R406 T957 T953 arg1Of activity,(
R407 T957 T956 arg1Of activity,DNA-binding
R408 T959 T958 arg1Of production,IL-17
R409 T959 T960 arg1Of production,by
R410 T959 T964 arg1Of production,is
R411 T959 T968 arg2Of production,blocked
R412 T963 T960 arg2Of PBMC,by
R413 T963 T961 arg2Of PBMC,activated
R414 T963 T962 arg1Of PBMC,RA
R415 T965 T966 arg1Of completely,or
R416 T967 T966 arg2Of partly,or
R417 T968 T964 arg2Of blocked,is
R418 T968 T965 arg1Of blocked,completely
R419 T968 T967 arg1Of blocked,partly
R420 T968 T969 arg1Of blocked,in
R421 T968 T985 arg1Of blocked,","
R422 T968 T986 arg1Of blocked,respectively
R423 T971 T970 arg1Of presence,the
R424 T971 T972 arg1Of presence,of
R425 T971 T978 arg1Of presence,and
R426 T977 T972 arg2Of dithiocarbamate,of
R427 T977 T973 arg1Of dithiocarbamate,the
R428 T977 T974 arg1Of dithiocarbamate,NF-κB
R429 T977 T975 arg1Of dithiocarbamate,inhibitor
R430 T977 T976 arg1Of dithiocarbamate,pyrrolidine
R431 T978 T969 arg2Of and,in
R432 T982 T983 arg1Of wortmannin,and
R433 T983 T978 arg2Of and,and
R434 T983 T979 arg1Of and,the
R435 T983 T980 arg1Of and,PI3K/Akt
R436 T983 T981 arg1Of and,inhibitor
R437 T984 T983 arg2Of LY294002,and
R438 T989 T990 arg1Of inhibition,of
R439 T989 T993 arg1Of inhibition,and
R440 T992 T990 arg2Of protein-1,of
R441 T992 T991 arg1Of protein-1,activator
R442 T993 T998 arg1Of and,did
R443 T993 T1000 arg1Of and,affect
R444 T996 T993 arg2Of kinase,and
R445 T996 T994 arg1Of kinase,extracellular
R446 T996 T995 arg1Of kinase,signal-regulated
R447 T996 T997 arg1Of kinase,1/2
R448 T1000 T987 arg1Of affect,However
R449 T1000 T988 arg1Of affect,","
R450 T1000 T998 arg2Of affect,did
R451 T1000 T999 arg1Of affect,not
R452 T1002 T1000 arg2Of production,affect
R453 T1002 T1001 arg1Of production,IL-17
R454 T1004 T1003 arg1Of results,These
R455 T1004 T1005 arg1Of results,suggest
R456 T1009 T1007 arg1Of pathways,signal
R457 T1009 T1008 arg1Of pathways,transduction
R458 T1009 T1010 arg1Of pathways,dependent
R459 T1009 T1015 arg1Of pathways,are
R460 T1009 T1016 arg2Of pathways,involved
R461 T1010 T1011 arg1Of dependent,on
R462 T1012 T1013 arg1Of PI3K/Akt,and
R463 T1013 T1011 arg2Of and,on
R464 T1014 T1013 arg2Of NF-κB,and
R465 T1016 T1005 arg2Of involved,suggest
R466 T1016 T1006 arg1Of involved,that
R467 T1016 T1015 arg2Of involved,are
R468 T1016 T1017 arg1Of involved,in
R469 T1019 T1017 arg2Of overproduction,in
R470 T1019 T1018 arg1Of overproduction,the
R471 T1019 T1020 arg1Of overproduction,of
R472 T1025 T1020 arg2Of IL-17,of
R473 T1025 T1021 arg1Of IL-17,the
R474 T1025 T1022 arg1Of IL-17,key
R475 T1025 T1023 arg1Of IL-17,inflammatory
R476 T1025 T1024 arg1Of IL-17,cytokine
R477 T1025 T1026 arg1Of IL-17,in
R478 T1027 T1026 arg2Of RA,in
R1151 T2894 T2893 arg1Of arthritis,Rheumatoid
R1152 T2894 T2895 arg1Of arthritis,(
R1153 T2894 T2898 arg1Of arthritis,is
R1154 T2894 T2899 arg2Of arthritis,characterized
R1155 T2896 T2895 arg2Of RA,(
R1156 T2897 T2895 arg3Of ),(
R1157 T2899 T2898 arg2Of characterized,is
R1158 T2901 T2899 arg1Of infiltrations,characterized
R1159 T2901 T2900 arg2Of infiltrations,by
R1160 T2901 T2902 arg1Of infiltrations,of
R1161 T2903 T2904 arg1Of macrophages,and
R1162 T2904 T2907 arg1Of and,into
R1163 T2904 T2911 arg1Of and,and
R1164 T2906 T2904 arg2Of cells,and
R1165 T2906 T2905 arg1Of cells,T
R1166 T2909 T2907 arg2Of joint,into
R1167 T2909 T2908 arg1Of joint,the
R1168 T2911 T2902 arg2Of and,of
R1169 T2911 T2910 arg1Of and,","
R1170 T2913 T2911 arg2Of hyperplasia,and
R1171 T2913 T2912 arg1Of hyperplasia,synovial
R1172 T2915 T2914 arg1Of cytokines,Proinflammatory
R1173 T2915 T2916 arg2Of cytokines,released
R1174 T2915 T2920 arg1Of cytokines,are
R1175 T2915 T2921 arg2Of cytokines,known
R1176 T2915 T2923 arg1Of cytokines,be
R1177 T2915 T2924 arg1Of cytokines,important
R1178 T2916 T2917 arg1Of released,from
R1179 T2919 T2917 arg2Of cells,from
R1180 T2919 T2918 arg1Of cells,these
R1181 T2921 T2920 arg2Of known,are
R1182 T2921 T2932 arg1Of known,[
R1183 T2923 T2921 arg3Of be,known
R1184 T2923 T2922 arg1Of be,to
R1185 T2924 T2923 arg2Of important,be
R1186 T2924 T2925 arg1Of important,in
R1187 T2927 T2925 arg2Of destruction,in
R1188 T2927 T2926 arg1Of destruction,the
R1189 T2927 T2928 arg1Of destruction,of
R1190 T2927 T2930 arg1Of destruction,in
R1191 T2929 T2928 arg2Of joints,of
R1192 T2931 T2930 arg2Of RA,in
R1193 T2933 T2932 arg2Of 1,[
R1194 T2934 T2932 arg3Of ],[
R1195 T2938 T2935 arg1Of benefits,The
R1196 T2938 T2936 arg1Of benefits,favorable
R1197 T2938 T2937 arg1Of benefits,clinical
R1198 T2938 T2939 arg2Of benefits,obtained
R1199 T2938 T2950 arg1Of benefits,)
R1200 T2938 T2951 arg1Of benefits,and
R1201 T2939 T2940 arg1Of obtained,with
R1202 T2941 T2940 arg2Of inhibitors,with
R1203 T2941 T2942 arg1Of inhibitors,of
R1204 T2945 T2943 arg1Of factor,tumor
R1205 T2945 T2944 arg1Of factor,necrosis
R1206 T2945 T2946 arg1Of factor,(
R1207 T2947 T2946 arg2Of TNF,(
R1208 T2948 T2946 arg3Of ),(
R1209 T2949 T2942 arg2Of -α,of
R1210 T2949 T2945 arg1Of -α,factor
R1211 T2951 T2957 arg1Of and,suggest
R1212 T2952 T2951 arg2Of interleukin,and
R1213 T2952 T2953 arg1Of interleukin,(
R1214 T2952 T2956 arg1Of interleukin,-1
R1215 T2954 T2953 arg2Of IL,(
R1216 T2955 T2953 arg3Of ),(
R1217 T2960 T2959 arg1Of blockade,the
R1218 T2960 T2961 arg1Of blockade,of
R1219 T2960 T2965 arg1Of blockade,has
R1220 T2960 T2966 arg1Of blockade,been
R1221 T2964 T2961 arg2Of cytokines,of
R1222 T2964 T2962 arg1Of cytokines,key
R1223 T2964 T2963 arg1Of cytokines,inflammatory
R1224 T2966 T2957 arg2Of been,suggest
R1225 T2966 T2958 arg1Of been,that
R1226 T2966 T2965 arg2Of been,has
R1227 T2966 T2970 arg1Of been,in
R1228 T2966 T2977 arg1Of been,[
R1229 T2969 T2966 arg2Of issue,been
R1230 T2969 T2967 arg1Of issue,the
R1231 T2969 T2968 arg1Of issue,important
R1232 T2972 T2970 arg2Of development,in
R1233 T2972 T2971 arg1Of development,the
R1234 T2972 T2973 arg1Of development,of
R1235 T2976 T2973 arg2Of applications,of
R1236 T2976 T2974 arg1Of applications,new
R1237 T2976 T2975 arg1Of applications,therapeutic
R1238 T2978 T2977 arg2Of 2,[
R1239 T2979 T2977 arg3Of ],[
R1240 T2981 T2980 arg1Of little,A
R1241 T2983 T2982 arg1Of a,over
R1242 T2984 T2983 arg1Of decade,a
R1243 T2985 T2981 arg1Of ago,little
R1244 T2985 T2984 arg1Of ago,decade
R1245 T2988 T2987 arg1Of primacy,the
R1246 T2988 T2989 arg1Of primacy,of
R1247 T2988 T2992 arg1Of primacy,in
R1248 T2988 T2999 arg1Of primacy,as
R1249 T2988 T3001 arg1Of primacy,was
R1250 T2988 T3002 arg1Of primacy,undisputed
R1251 T2991 T2989 arg2Of cells,of
R1252 T2991 T2990 arg1Of cells,T
R1253 T2994 T2992 arg2Of pathogenesis,in
R1254 T2994 T2993 arg1Of pathogenesis,the
R1255 T2994 T2995 arg1Of pathogenesis,of
R1256 T2997 T2995 arg2Of disease,of
R1257 T2997 T2996 arg1Of disease,autoimmune
R1258 T2999 T2998 arg1Of as,such
R1259 T3000 T2999 arg2Of RA,as
R1260 T3001 T2985 arg1Of was,ago
R1261 T3001 T2986 arg1Of was,","
R1262 T3001 T3003 arg1Of was,because
R1263 T3002 T3001 arg2Of undisputed,was
R1264 T3004 T3005 arg1Of they,are
R1265 T3005 T3003 arg2Of are,because
R1266 T3009 T3005 arg2Of population,are
R1267 T3009 T3006 arg1Of population,the
R1268 T3009 T3007 arg1Of population,largest
R1269 T3009 T3008 arg1Of population,cell
R1270 T3009 T3010 arg1Of population,infiltrating
R1271 T3012 T3010 arg2Of synovium,infiltrating
R1272 T3012 T3011 arg1Of synovium,the
R1273 T3016 T3015 arg1Of series,a
R1274 T3016 T3017 arg1Of series,of
R1275 T3016 T3019 arg1Of series,demonstrated
R1276 T3018 T3017 arg2Of studies,of
R1277 T3019 T3013 arg1Of demonstrated,However
R1278 T3019 T3014 arg1Of demonstrated,","
R1279 T3019 T3035 arg1Of demonstrated,","
R1280 T3019 T3036 arg1Of demonstrated,whereas
R1281 T3020 T3019 arg2Of paucity,demonstrated
R1282 T3020 T3021 arg1Of paucity,of
R1283 T3024 T3021 arg2Of cytokines,of
R1284 T3024 T3022 arg1Of cytokines,T
R1285 T3024 T3023 arg1Of cytokines,cell-derived
R1286 T3024 T3026 arg1Of cytokines,as
R1287 T3026 T3025 arg1Of as,such
R1288 T3027 T3028 arg1Of IL-2,and
R1289 T3028 T3026 arg2Of and,as
R1290 T3028 T3030 arg1Of and,in
R1291 T3029 T3028 arg2Of interferon-γ,and
R1292 T3032 T3030 arg2Of joints,in
R1293 T3032 T3031 arg1Of joints,the
R1294 T3032 T3033 arg1Of joints,of
R1295 T3034 T3033 arg2Of RA,of
R1296 T3037 T3038 arg1Of macrophage,and
R1297 T3039 T3038 arg2Of fibroblast,and
R1298 T3040 T3037 arg1Of cytokines,macrophage
R1299 T3040 T3039 arg1Of cytokines,fibroblast
R1300 T3040 T3041 arg1Of cytokines,including
R1301 T3040 T3051 arg1Of cytokines,were
R1302 T3040 T3052 arg1Of cytokines,abundant
R1303 T3042 T3043 arg1Of IL-1,","
R1304 T3043 T3045 arg1Of ",",","
R1305 T3044 T3043 arg2Of IL-6,","
R1306 T3045 T3047 arg1Of ",",","
R1307 T3046 T3045 arg2Of IL-15,","
R1308 T3047 T3049 arg1Of ",",and
R1309 T3048 T3047 arg2Of IL-18,","
R1310 T3049 T3041 arg2Of and,including
R1311 T3050 T3049 arg2Of TNF-α,and
R1312 T3051 T3036 arg2Of were,whereas
R1313 T3051 T3053 arg1Of were,in
R1314 T3052 T3051 arg2Of abundant,were
R1315 T3055 T3053 arg2Of synovium,in
R1316 T3055 T3054 arg1Of synovium,rheumatoid
R1317 T3057 T3056 arg1Of paradox,This
R1318 T3057 T3058 arg1Of paradox,has
R1319 T3057 T3059 arg1Of paradox,questioned
R1320 T3059 T3058 arg2Of questioned,has
R1321 T3061 T3059 arg2Of role,questioned
R1322 T3061 T3060 arg1Of role,the
R1323 T3061 T3062 arg1Of role,of
R1324 T3061 T3065 arg1Of role,in
R1325 T3064 T3062 arg2Of cells,of
R1326 T3064 T3063 arg1Of cells,T
R1327 T3067 T3065 arg2Of pathogenesis,in
R1328 T3067 T3066 arg1Of pathogenesis,the
R1329 T3067 T3068 arg1Of pathogenesis,of
R1330 T3069 T3068 arg2Of RA,of
R1331 T3069 T3070 arg1Of RA,[
R1332 T3071 T3070 arg2Of 3,[
R1333 T3072 T3070 arg3Of ],[
R1334 T3074 T3075 arg1Of we,have
R1335 T3074 T3077 arg1Of we,demonstrated
R1336 T3077 T3073 arg2Of demonstrated,Because
R1337 T3077 T3075 arg2Of demonstrated,have
R1338 T3077 T3076 arg1Of demonstrated,already
R1339 T3077 T3105 arg1Of demonstrated,in
R1340 T3080 T3078 arg1Of proliferation,the
R1341 T3080 T3079 arg2Of proliferation,enhanced
R1342 T3080 T3081 arg1Of proliferation,of
R1343 T3080 T3086 arg1Of proliferation,","
R1344 T3080 T3088 arg1Of proliferation,to
R1345 T3080 T3093 arg1Of proliferation,and
R1346 T3085 T3081 arg2Of cells,of
R1347 T3085 T3082 arg1Of cells,antigen
R1348 T3085 T3083 arg1Of cells,specific
R1349 T3085 T3084 arg1Of cells,T
R1350 T3088 T3087 arg1Of to,especially
R1351 T3091 T3088 arg2Of collagen,to
R1352 T3091 T3089 arg1Of collagen,type
R1353 T3091 T3090 arg1Of collagen,II
R1354 T3093 T3077 arg2Of and,demonstrated
R1355 T3093 T3092 arg1Of and,","
R1356 T3095 T3093 arg2Of skewing,and
R1357 T3095 T3094 arg1Of skewing,the
R1358 T3095 T3096 arg1Of skewing,of
R1359 T3102 T3101 arg2Of Th1,(
R1360 T3103 T3101 arg3Of ),(
R1361 T3104 T3096 arg2Of cytokines,of
R1362 T3104 T3097 arg1Of cytokines,T
R1363 T3104 T3098 arg1Of cytokines,helper
R1364 T3104 T3099 arg1Of cytokines,type
R1365 T3104 T3100 arg1Of cytokines,1
R1366 T3104 T3101 arg1Of cytokines,(
R1367 T3106 T3105 arg2Of RA,in
R1368 T3106 T3107 arg1Of RA,[
R1369 T3108 T3107 arg2Of 4,[
R1370 T3109 T3107 arg3Of ],[
R1371 T3112 T3111 arg1Of role,the
R1372 T3112 T3113 arg1Of role,of
R1373 T3112 T3116 arg1Of role,needs
R1374 T3112 T3118 arg1Of role,be
R1375 T3112 T3119 arg2Of role,elucidated
R1376 T3115 T3113 arg2Of cells,of
R1377 T3115 T3114 arg1Of cells,T
R1378 T3116 T3073 arg1Of needs,Because
R1379 T3116 T3110 arg1Of needs,","
R1380 T3119 T3116 arg2Of elucidated,needs
R1381 T3119 T3117 arg1Of elucidated,to
R1382 T3119 T3118 arg2Of elucidated,be
R1383 T3119 T3120 arg1Of elucidated,in
R1384 T3122 T3120 arg2Of aspects,in
R1385 T3122 T3121 arg1Of aspects,different
R1386 T3123 T3124 arg1Of IL-17,is
R1387 T3125 T3124 arg2Of one,is
R1388 T3125 T3126 arg1Of one,of
R1389 T3129 T3126 arg2Of cytokines,of
R1390 T3129 T3127 arg1Of cytokines,the
R1391 T3129 T3128 arg1Of cytokines,inflammatory
R1392 T3129 T3130 arg2Of cytokines,secreted
R1393 T3135 T3130 arg1Of cells,secreted
R1394 T3135 T3131 arg1Of cells,mainly
R1395 T3135 T3132 arg2Of cells,by
R1396 T3135 T3133 arg2Of cells,activated
R1397 T3135 T3134 arg1Of cells,T
R1398 T3135 T3136 arg1Of cells,","
R1399 T3135 T3137 arg1Of cells,which
R1400 T3135 T3138 arg1Of cells,can
R1401 T3135 T3139 arg1Of cells,induce
R1402 T3139 T3138 arg2Of induce,can
R1403 T3139 T3145 arg1Of induce,[
R1404 T3140 T3141 arg1Of IL-6,and
R1405 T3141 T3139 arg2Of and,induce
R1406 T3141 T3143 arg1Of and,by
R1407 T3142 T3141 arg2Of IL-8,and
R1408 T3144 T3143 arg2Of fibroblasts,by
R1409 T3146 T3145 arg2Of 5,[
R1410 T3147 T3145 arg3Of ],[
R1411 T3149 T3148 arg1Of cytokine,This
R1412 T3149 T3150 arg1Of cytokine,is
R1413 T3149 T3151 arg1Of cytokine,of
R1414 T3150 T3153 arg1Of is,for
R1415 T3150 T3157 arg1Of is,:
R1416 T3151 T3150 arg2Of of,is
R1417 T3152 T3151 arg2Of interest,of
R1418 T3156 T3153 arg2Of reasons,for
R1419 T3156 T3154 arg1Of reasons,two
R1420 T3156 T3155 arg1Of reasons,major
R1421 T3158 T3159 arg1Of first,","
R1422 T3160 T3159 arg2Of similarly,","
R1423 T3160 T3161 arg1Of similarly,to
R1424 T3162 T3163 arg1Of TNF-α,and
R1425 T3163 T3161 arg2Of and,to
R1426 T3164 T3163 arg2Of IL-1,and
R1427 T3166 T3167 arg1Of IL-17,has
R1428 T3167 T3157 arg2Of has,:
R1429 T3167 T3158 arg1Of has,first
R1430 T3167 T3160 arg1Of has,similarly
R1431 T3167 T3165 arg1Of has,","
R1432 T3167 T3170 arg1Of has,;
R1433 T3169 T3167 arg2Of properties,has
R1434 T3169 T3168 arg1Of properties,proinflammatory
R1435 T3173 T3174 arg1Of it,is
R1436 T3173 T3175 arg2Of it,produced
R1437 T3175 T3170 arg2Of produced,;
R1438 T3175 T3171 arg1Of produced,second
R1439 T3175 T3172 arg1Of produced,","
R1440 T3175 T3174 arg2Of produced,is
R1441 T3175 T3179 arg1Of produced,[
R1442 T3178 T3175 arg1Of cells,produced
R1443 T3178 T3176 arg2Of cells,by
R1444 T3178 T3177 arg1Of cells,T
R1445 T3180 T3179 arg2Of 6,[
R1446 T3181 T3179 arg3Of ],[
R1447 T3183 T3182 arg1Of observations,Recent
R1448 T3183 T3184 arg1Of observations,demonstrated
R1449 T3186 T3187 arg1Of IL-17,can
R1450 T3186 T3189 arg1Of IL-17,activate
R1451 T3189 T3184 arg2Of activate,demonstrated
R1452 T3189 T3185 arg1Of activate,that
R1453 T3189 T3187 arg2Of activate,can
R1454 T3189 T3188 arg1Of activate,also
R1455 T3189 T3193 arg1Of activate,by
R1456 T3192 T3189 arg2Of resorption,activate
R1457 T3192 T3190 arg1Of resorption,osteoclastic
R1458 T3192 T3191 arg1Of resorption,bone
R1459 T3195 T3193 arg2Of induction,by
R1460 T3195 T3194 arg1Of induction,the
R1461 T3195 T3196 arg1Of induction,of
R1462 T3195 T3198 arg1Of induction,(
R1463 T3195 T3210 arg1Of induction,","
R1464 T3195 T3211 arg1Of induction,which
R1465 T3195 T3212 arg1Of induction,is
R1466 T3195 T3213 arg2Of induction,involved
R1467 T3197 T3196 arg2Of RANKL,of
R1468 T3200 T3198 arg2Of activator,(
R1469 T3200 T3199 arg1Of activator,receptor
R1470 T3200 T3201 arg1Of activator,of
R1471 T3206 T3205 arg2Of NF-κB,[
R1472 T3207 T3205 arg3Of ],[
R1473 T3208 T3201 arg2Of ligand,of
R1474 T3208 T3202 arg1Of ligand,nuclear
R1475 T3208 T3203 arg1Of ligand,factor
R1476 T3208 T3204 arg1Of ligand,κB
R1477 T3208 T3205 arg1Of ligand,[
R1478 T3209 T3198 arg3Of ),(
R1479 T3213 T3212 arg2Of involved,is
R1480 T3213 T3214 arg1Of involved,in
R1481 T3216 T3214 arg2Of erosion,in
R1482 T3216 T3215 arg1Of erosion,bony
R1483 T3216 T3217 arg1Of erosion,in
R1484 T3218 T3217 arg2Of RA,in
R1485 T3218 T3219 arg1Of RA,[
R1486 T3220 T3219 arg2Of 7,[
R1487 T3221 T3219 arg3Of ],[
R1488 T3222 T3224 arg1Of It,stimulates
R1489 T3222 T3247 arg1Of It,has
R1490 T3224 T3246 arg1Of stimulates,and
R1491 T3226 T3224 arg2Of production,stimulates
R1492 T3226 T3225 arg1Of production,the
R1493 T3226 T3227 arg1Of production,of
R1494 T3226 T3237 arg1Of production,of
R1495 T3227 T3236 arg1Of of,and
R1496 T3228 T3229 arg1Of IL-6,and
R1497 T3229 T3227 arg2Of and,of
R1498 T3229 T3233 arg1Of and,by
R1499 T3232 T3229 arg2Of factor,and
R1500 T3232 T3230 arg1Of factor,leukemia
R1501 T3232 T3231 arg1Of factor,inhibitory
R1502 T3234 T3233 arg2Of synoviocytes,by
R1503 T3236 T3235 arg1Of and,","
R1504 T3237 T3236 arg2Of of,and
R1505 T3239 T3238 arg1Of E2,prostaglandin
R1506 T3239 T3240 arg1Of E2,and
R1507 T3240 T3237 arg2Of and,of
R1508 T3240 T3243 arg1Of and,by
R1509 T3242 T3240 arg2Of oxide,and
R1510 T3242 T3241 arg1Of oxide,nitric
R1511 T3244 T3243 arg2Of chondrocytes,by
R1512 T3246 T3223 arg1Of and,also
R1513 T3246 T3245 arg1Of and,","
R1514 T3247 T3246 arg2Of has,and
R1515 T3249 T3247 arg2Of ability,has
R1516 T3249 T3248 arg1Of ability,the
R1517 T3249 T3250 modOf ability,to
R1518 T3251 T3252 arg1Of differentiate,and
R1519 T3252 T3250 arg1Of and,to
R1520 T3252 T3257 arg1Of and,[
R1521 T3253 T3252 arg2Of activate,and
R1522 T3256 T3251 arg2Of cells,differentiate
R1523 T3256 T3253 arg2Of cells,activate
R1524 T3256 T3254 arg1Of cells,the
R1525 T3256 T3255 arg1Of cells,dendritic
R1526 T3258 T3257 arg2Of 8-10,[
R1527 T3259 T3257 arg3Of ],[
R1528 T3260 T3261 arg1Of Levels,of
R1529 T3260 T3263 arg1Of Levels,in
R1530 T3260 T3266 arg1Of Levels,were
R1531 T3260 T3268 arg1Of Levels,higher
R1532 T3262 T3261 arg2Of IL-17,of
R1533 T3265 T3263 arg2Of fluids,in
R1534 T3265 T3264 arg1Of fluids,synovial
R1535 T3266 T3282 arg1Of were,and
R1536 T3268 T3266 arg2Of higher,were
R1537 T3268 T3267 arg1Of higher,significantly
R1538 T3268 T3269 arg1Of higher,in
R1539 T3268 T3273 arg1Of higher,than
R1540 T3270 T3269 arg2Of patients,in
R1541 T3270 T3271 arg1Of patients,with
R1542 T3272 T3271 arg2Of RA,with
R1543 T3274 T3273 arg2Of in,than
R1544 T3275 T3274 arg2Of patients,in
R1545 T3275 T3276 arg1Of patients,with
R1546 T3277 T3276 arg2Of osteoarthritis,with
R1547 T3277 T3278 arg1Of osteoarthritis,(
R1548 T3279 T3278 arg2Of OA,(
R1549 T3280 T3278 arg3Of ),(
R1550 T3282 T3281 arg1Of and,","
R1551 T3282 T3293 arg1Of and,[
R1552 T3283 T3284 arg1Of it,was
R1553 T3283 T3285 arg2Of it,produced
R1554 T3285 T3282 arg2Of produced,and
R1555 T3285 T3284 arg2Of produced,was
R1556 T3285 T3290 arg1Of produced,in
R1557 T3289 T3285 arg1Of cells,produced
R1558 T3289 T3286 arg2Of cells,by
R1559 T3289 T3287 arg1Of cells,CD4+
R1560 T3289 T3288 arg1Of cells,T
R1561 T3292 T3290 arg2Of synovium,in
R1562 T3292 T3291 arg1Of synovium,the
R1563 T3294 T3293 arg2Of "11,12",[
R1564 T3295 T3293 arg3Of ],[
R1565 T3296 T3297 arg1Of IL-15,","
R1566 T3296 T3298 arg2Of IL-15,secreted
R1567 T3296 T3303 arg1Of IL-15,has
R1568 T3296 T3304 arg1Of IL-15,been
R1569 T3296 T3305 arg2Of IL-15,reported
R1570 T3296 T3307 arg1Of IL-15,be
R1571 T3298 T3299 arg1Of secreted,from
R1572 T3301 T3299 arg2Of macrophages,from
R1573 T3301 T3300 arg2Of macrophages,activated
R1574 T3305 T3302 arg1Of reported,","
R1575 T3305 T3303 arg2Of reported,has
R1576 T3305 T3304 arg2Of reported,been
R1577 T3307 T3305 arg3Of be,reported
R1578 T3307 T3306 arg1Of be,to
R1579 T3307 T3314 arg1Of be,in
R1580 T3307 T3323 arg1Of be,by
R1581 T3307 T3329 arg1Of be,[
R1582 T3310 T3307 arg2Of trigger,be
R1583 T3310 T3308 arg1Of trigger,an
R1584 T3310 T3309 arg1Of trigger,important
R1585 T3310 T3311 arg1Of trigger,of
R1586 T3313 T3311 arg2Of production,of
R1587 T3313 T3312 arg1Of production,IL-17
R1588 T3319 T3314 arg2Of cells,in
R1589 T3319 T3315 arg1Of cells,RA
R1590 T3319 T3316 arg1Of cells,peripheral
R1591 T3319 T3317 arg1Of cells,blood
R1592 T3319 T3318 arg1Of cells,mononuclear
R1593 T3319 T3320 arg1Of cells,(
R1594 T3321 T3320 arg2Of PBMC,(
R1595 T3322 T3320 arg3Of ),(
R1596 T3324 T3325 arg1Of cyclosporine,and
R1597 T3325 T3323 arg2Of and,by
R1598 T3328 T3325 arg2Of pathways,and
R1599 T3328 T3326 arg1Of pathways,steroid
R1600 T3328 T3327 arg1Of pathways,sensitive
R1601 T3330 T3329 arg2Of 13,[
R1602 T3331 T3329 arg3Of ],[
R1603 T3334 T3335 arg1Of Happel,and
R1604 T3335 T3338 arg1Of and,showed
R1605 T3336 T3335 arg2Of colleagues,and
R1606 T3338 T3332 arg1Of showed,Recently
R1607 T3338 T3333 arg1Of showed,","
R1608 T3338 T3337 arg1Of showed,also
R1609 T3340 T3341 arg1Of IL-23,could
R1610 T3340 T3342 arg1Of IL-23,be
R1611 T3342 T3338 arg2Of be,showed
R1612 T3342 T3339 arg1Of be,that
R1613 T3342 T3341 arg2Of be,could
R1614 T3345 T3342 arg2Of trigger,be
R1615 T3345 T3343 arg1Of trigger,an
R1616 T3345 T3344 arg1Of trigger,efficient
R1617 T3345 T3346 arg1Of trigger,of
R1618 T3345 T3349 arg1Of trigger,from
R1619 T3348 T3346 arg2Of production,of
R1620 T3348 T3347 arg1Of production,IL-17
R1621 T3351 T3352 arg1Of CD4+,and
R1622 T3353 T3352 arg2Of CD8+,and
R1623 T3355 T3349 arg2Of cells,from
R1624 T3355 T3350 arg1Of cells,both
R1625 T3355 T3351 arg1Of cells,CD4+
R1626 T3355 T3353 arg1Of cells,CD8+
R1627 T3355 T3354 arg1Of cells,T
R1628 T3355 T3356 arg1Of cells,[
R1629 T3357 T3356 arg2Of 14,[
R1630 T3358 T3356 arg3Of ],[
R1631 T3361 T3360 arg1Of contribution,the
R1632 T3361 T3362 arg1Of contribution,of
R1633 T3361 T3364 arg1Of contribution,in
R1634 T3361 T3369 arg1Of contribution,has
R1635 T3361 T3370 arg1Of contribution,been
R1636 T3361 T3371 arg2Of contribution,documented
R1637 T3363 T3362 arg2Of IL-17,of
R1638 T3366 T3364 arg2Of inflammation,in
R1639 T3366 T3365 arg1Of inflammation,joint
R1640 T3366 T3367 arg1Of inflammation,in
R1641 T3368 T3367 arg2Of RA,in
R1642 T3371 T3359 arg2Of documented,Although
R1643 T3371 T3369 arg2Of documented,has
R1644 T3371 T3370 arg2Of documented,been
R1645 T3371 T3372 arg1Of documented,in
R1646 T3374 T3372 arg2Of studies,in
R1647 T3374 T3373 arg1Of studies,earlier
R1648 T3374 T3375 arg1Of studies,[
R1649 T3376 T3375 arg2Of "12,15,16",[
R1650 T3377 T3375 arg3Of ],[
R1651 T3383 T3379 arg1Of pathway,the
R1652 T3383 T3380 arg1Of pathway,intracellular
R1653 T3383 T3381 arg1Of pathway,signal
R1654 T3383 T3382 arg1Of pathway,transduction
R1655 T3383 T3384 arg1Of pathway,for
R1656 T3383 T3387 arg1Of pathway,remains
R1657 T3383 T3388 arg1Of pathway,uncertain
R1658 T3386 T3384 arg2Of production,for
R1659 T3386 T3385 arg1Of production,IL-17
R1660 T3387 T3359 arg1Of remains,Although
R1661 T3387 T3378 arg1Of remains,","
R1662 T3388 T3387 arg2Of uncertain,remains
R1663 T3392 T3389 arg2Of study,In
R1664 T3392 T3390 arg1Of study,the
R1665 T3392 T3391 arg1Of study,present
R1666 T3393 T3394 arg1Of we,used
R1667 T3393 T3398 arg1Of we,investigate
R1668 T3394 T3389 arg1Of used,In
R1669 T3396 T3394 arg2Of stimuli,used
R1670 T3396 T3395 arg1Of stimuli,various
R1671 T3398 T3394 arg3Of investigate,used
R1672 T3398 T3397 arg1Of investigate,to
R1673 T3400 T3398 arg2Of production,investigate
R1674 T3400 T3399 arg1Of production,IL-17
R1675 T3400 T3401 arg1Of production,in
R1676 T3402 T3403 arg1Of PBMC,of
R1677 T3402 T3407 arg1Of PBMC,and
R1678 T3404 T3403 arg2Of patients,of
R1679 T3404 T3405 arg1Of patients,with
R1680 T3406 T3405 arg2Of RA,with
R1681 T3407 T3401 arg2Of and,in
R1682 T3411 T3407 arg2Of pathway,and
R1683 T3411 T3408 arg1Of pathway,its
R1684 T3411 T3409 arg1Of pathway,signaling
R1685 T3411 T3410 arg1Of pathway,transduction
R1686 T3412 T3413 arg1Of We,found
R1687 T3418 T3415 arg1Of pathway,the
R1688 T3418 T3416 arg1Of pathway,intracellular
R1689 T3418 T3417 arg1Of pathway,signaling
R1690 T3418 T3419 arg1Of pathway,involving
R1691 T3418 T3428 arg1Of pathway,might
R1692 T3418 T3429 arg1Of pathway,be
R1693 T3418 T3430 arg2Of pathway,involved
R1694 T3423 T3422 arg2Of PI3K,(
R1695 T3424 T3422 arg3Of ),(
R1696 T3425 T3426 arg1Of /Akt,and
R1697 T3426 T3419 arg2Of and,involving
R1698 T3426 T3420 arg1Of and,phosphoinositide
R1699 T3426 T3421 arg1Of and,3-kinase
R1700 T3426 T3422 arg1Of and,(
R1701 T3427 T3426 arg2Of NF-κB,and
R1702 T3430 T3413 arg2Of involved,found
R1703 T3430 T3414 arg1Of involved,that
R1704 T3430 T3428 arg2Of involved,might
R1705 T3430 T3429 arg2Of involved,be
R1706 T3430 T3431 arg1Of involved,in
R1707 T3433 T3431 arg2Of overproduction,in
R1708 T3433 T3432 arg1Of overproduction,the
R1709 T3433 T3434 arg1Of overproduction,of
R1710 T3439 T3434 arg2Of IL-17,of
R1711 T3439 T3435 arg1Of IL-17,the
R1712 T3439 T3436 arg1Of IL-17,key
R1713 T3439 T3437 arg1Of IL-17,inflammatory
R1714 T3439 T3438 arg1Of IL-17,cytokine
R1715 T3439 T3440 arg1Of IL-17,in
R1716 T3441 T3440 arg2Of RA,in
R1717 T3443 T3442 arg1Of results,These
R1718 T3443 T3444 arg1Of results,might
R1719 T3443 T3445 arg1Of results,provide
R1720 T3445 T3444 arg2Of provide,might
R1721 T3445 T3448 arg1Of provide,into
R1722 T3447 T3445 arg2Of insights,provide
R1723 T3447 T3446 arg1Of insights,new
R1724 T3450 T3448 arg2Of pathogenesis,into
R1725 T3450 T3449 arg1Of pathogenesis,the
R1727 T3450 T3451 arg1Of pathogenesis,of
R1729 T3450 T3456 arg1Of pathogenesis,for
R1730 T3452 T3453 arg1Of RA,and
R1733 T3453 T3451 arg2Of and,of
R1734 T3455 T3453 arg2Of directions,and
R1735 T3455 T3454 arg1Of directions,future
R1740 T3458 T3457 arg1Of therapeutic,new
R1742 T3459 T3456 arg2Of strategies,for
R1745 T3459 T3458 arg1Of strategies,therapeutic
R1747 T3459 T3460 arg1Of strategies,in
R1748 T3461 T3460 arg2Of RA,in
R2483 T4883 T4882 arg2Of consent,Informed
R2484 T4883 T4884 arg1Of consent,was
R2485 T4883 T4885 arg2Of consent,obtained
R2486 T4885 T4884 arg2Of obtained,was
R2487 T4885 T4886 arg1Of obtained,from
R2488 T4888 T4886 arg2Of patients,from
R2489 T4888 T4887 arg1Of patients,24
R2490 T4888 T4889 arg1Of patients,(
R2491 T4888 T4896 arg1Of patients,with
R2492 T4891 T4890 arg1Of men,5
R2493 T4891 T4892 arg1Of men,and
R2494 T4892 T4889 arg2Of and,(
R2495 T4894 T4892 arg2Of women,and
R2496 T4894 T4893 arg1Of women,19
R2497 T4895 T4889 arg3Of ),(
R2498 T4897 T4896 arg2Of RA,with
R2499 T4897 T4898 arg1Of RA,who
R2500 T4897 T4899 arg1Of RA,fulfilled
R2501 T4899 T4917 arg1Of fulfilled,[
R2502 T4903 T4899 arg2Of criteria,fulfilled
R2503 T4903 T4900 arg1Of criteria,the
R2504 T4903 T4901 arg1Of criteria,1987
R2505 T4903 T4902 arg2Of criteria,revised
R2506 T4903 T4904 arg1Of criteria,of
R2507 T4903 T4910 arg1Of criteria,(
R2508 T4907 T4904 arg2Of College,of
R2509 T4907 T4905 arg1Of College,the
R2510 T4907 T4906 arg1Of College,American
R2511 T4907 T4908 arg1Of College,of
R2512 T4909 T4908 arg2Of Rheumatology,of
R2513 T4915 T4910 arg2Of Association,(
R2514 T4915 T4911 arg1Of Association,formerly
R2515 T4915 T4912 arg1Of Association,the
R2516 T4915 T4913 arg1Of Association,American
R2517 T4915 T4914 arg1Of Association,Rheumatism
R2518 T4916 T4910 arg3Of ),(
R2519 T4918 T4917 arg2Of 17,[
R2520 T4919 T4917 arg3Of ],[
R2521 T4921 T4920 arg1Of age,The
R2522 T4921 T4922 arg1Of age,of
R2523 T4921 T4927 arg1Of age,was
R2524 T4924 T4922 arg2Of patients,of
R2525 T4924 T4923 arg1Of patients,the
R2526 T4924 T4925 arg1Of patients,with
R2527 T4926 T4925 arg2Of RA,with
R2528 T4932 T4933 arg1Of mean,±
R2529 T4933 T4931 arg2Of ±,(
R2530 T4934 T4933 arg2Of SEM,±
R2531 T4935 T4931 arg3Of ),(
R2532 T4936 T4927 arg2Of years,was
R2533 T4936 T4928 arg1Of years,50
R2534 T4936 T4929 arg1Of years,±
R2535 T4936 T4930 arg1Of years,8
R2536 T4936 T4931 arg1Of years,(
R2537 T4936 T4937 arg1Of years,(
R2538 T4940 T4937 arg2Of years,(
R2539 T4940 T4938 arg1Of years,range
R2540 T4940 T4939 arg1Of years,23–71
R2541 T4941 T4937 arg3Of ),(
R2542 T4943 T4942 arg1Of medications,All
R2543 T4943 T4944 arg1Of medications,were
R2544 T4943 T4945 arg2Of medications,stopped
R2545 T4945 T4944 arg2Of stopped,were
R2546 T4945 T4948 arg1Of stopped,before
R2547 T4947 T4946 arg1Of hours,48
R2548 T4948 T4947 arg1Of before,hours
R2549 T4949 T4948 arg2Of entry,before
R2550 T4949 T4950 arg1Of entry,to
R2551 T4952 T4950 arg2Of study,to
R2552 T4952 T4951 arg1Of study,the
R2553 T4953 T4954 arg1Of Comparisons,were
R2554 T4953 T4955 arg2Of Comparisons,made
R2555 T4955 T4954 arg2Of made,were
R2556 T4955 T4956 arg1Of made,with
R2557 T4955 T4969 arg1Of made,with
R2558 T4956 T4968 arg1Of with,and
R2559 T4958 T4956 arg2Of patients,with
R2560 T4958 T4957 arg1Of patients,14
R2561 T4958 T4959 arg1Of patients,with
R2562 T4958 T4961 arg1Of patients,(
R2563 T4960 T4959 arg2Of OA,with
R2564 T4963 T4962 arg1Of men,3
R2565 T4963 T4964 arg1Of men,and
R2566 T4964 T4961 arg2Of and,(
R2567 T4966 T4964 arg2Of women,and
R2568 T4966 T4965 arg1Of women,11
R2569 T4967 T4961 arg3Of ),(
R2570 T4969 T4968 arg2Of with,and
R2571 T4972 T4969 arg2Of controls,with
R2572 T4972 T4970 arg1Of controls,14
R2573 T4972 T4971 arg1Of controls,healthy
R2574 T4972 T4973 arg1Of controls,(
R2575 T4972 T4980 arg1Of controls,who
R2576 T4972 T4981 arg1Of controls,had
R2577 T4975 T4974 arg1Of men,3
R2578 T4975 T4976 arg1Of men,and
R2579 T4976 T4973 arg2Of and,(
R2580 T4978 T4976 arg2Of women,and
R2581 T4978 T4977 arg1Of women,11
R2582 T4979 T4973 arg3Of ),(
R2583 T4984 T4981 arg2Of diseases,had
R2584 T4984 T4982 arg1Of diseases,no
R2585 T4984 T4983 arg1Of diseases,rheumatic
R2586 T4987 T4985 arg1Of ages,The
R2587 T4987 T4986 arg1Of ages,mean
R2588 T4987 T4988 arg1Of ages,of
R2589 T4987 T4997 arg1Of ages,were
R2590 T4990 T4989 arg1Of patients,the
R2591 T4990 T4991 arg1Of patients,with
R2592 T4990 T4993 arg1Of patients,and
R2593 T4992 T4991 arg2Of OA,with
R2594 T4993 T4988 arg2Of and,of
R2595 T4996 T4993 arg2Of controls,and
R2596 T4996 T4994 arg1Of controls,the
R2597 T4996 T4995 arg1Of controls,healthy
R2598 T4998 T4999 arg1Of 50,±
R2599 T5000 T4999 arg2Of 8,±
R2600 T5001 T4998 arg1Of years,50
R2601 T5001 T5000 arg1Of years,8
R2602 T5001 T5002 arg1Of years,(
R2603 T5001 T5007 arg1Of years,and
R2604 T5005 T5002 arg2Of years,(
R2605 T5005 T5003 arg1Of years,range
R2606 T5005 T5004 arg1Of years,34–68
R2607 T5006 T5002 arg3Of ),(
R2608 T5007 T4997 arg2Of and,were
R2609 T5008 T5009 arg1Of 30,±
R2610 T5010 T5009 arg2Of 6,±
R2611 T5011 T5007 arg2Of years,and
R2612 T5011 T5008 arg1Of years,30
R2613 T5011 T5010 arg1Of years,6
R2614 T5011 T5012 arg1Of years,(
R2615 T5015 T5012 arg2Of years,(
R2616 T5015 T5013 arg1Of years,range
R2617 T5015 T5014 arg1Of years,24–57
R2618 T5016 T5012 arg3Of ),(
R2619 T5018 T5017 arg2Of consent,Informed
R2620 T5018 T5019 arg1Of consent,was
R2621 T5018 T5020 arg2Of consent,obtained
R2622 T5020 T5019 arg2Of obtained,was
R2623 T5020 T5022 arg1Of obtained,and
R2624 T5022 T5021 arg1Of and,","
R2625 T5024 T5023 arg1Of protocol,the
R2626 T5024 T5025 arg1Of protocol,was
R2627 T5024 T5026 arg2Of protocol,approved
R2628 T5026 T5022 arg2Of approved,and
R2629 T5026 T5025 arg2Of approved,was
R2630 T5030 T5026 arg1Of University,approved
R2631 T5030 T5027 arg2Of University,by
R2632 T5030 T5028 arg1Of University,the
R2633 T5030 T5029 arg1Of University,Catholic
R2634 T5030 T5031 arg1Of University,of
R2635 T5036 T5031 arg2Of Committee,of
R2636 T5036 T5032 arg1Of Committee,Korea
R2637 T5036 T5033 arg1Of Committee,Human
R2638 T5036 T5034 arg1Of Committee,Research
R2639 T5036 T5035 arg1Of Committee,Ethics
R2810 T5376 T5375 arg1Of IL-17,Recombinant
R2811 T5376 T5377 arg1Of IL-17,","
R2812 T5377 T5379 arg1Of ",",","
R2813 T5378 T5377 arg2Of IL-18,","
R2814 T5379 T5381 arg1Of ",",","
R2815 T5380 T5379 arg2Of IL-15,","
R2816 T5381 T5388 arg1Of ",",","
R2817 T5384 T5381 arg2Of protein-1,","
R2818 T5384 T5382 arg1Of protein-1,monocyte
R2819 T5384 T5383 arg1Of protein-1,chemoattractant
R2820 T5384 T5385 arg1Of protein-1,(
R2821 T5386 T5385 arg2Of MCP-1,(
R2822 T5387 T5385 arg3Of ),(
R2823 T5388 T5402 arg1Of ",",were
R2824 T5388 T5403 arg2Of ",",purchased
R2825 T5391 T5389 arg1Of protein,macrophage
R2826 T5391 T5390 arg1Of protein,inflammatory
R2827 T5391 T5392 arg1Of protein,(
R2828 T5393 T5392 arg2Of MIP,(
R2829 T5394 T5392 arg3Of ),(
R2830 T5395 T5396 arg1Of -1α,","
R2831 T5396 T5398 arg1Of ",",","
R2832 T5397 T5396 arg2Of MIP-1β,","
R2833 T5398 T5400 arg1Of ",",and
R2834 T5399 T5398 arg2Of IL-6,","
R2835 T5400 T5388 arg2Of and,","
R2836 T5400 T5391 arg1Of and,protein
R2837 T5401 T5400 arg2Of IL-8,and
R2838 T5403 T5402 arg2Of purchased,were
R2839 T5403 T5404 arg1Of purchased,from
R2840 T5403 T5409 arg1Of purchased,(
R2841 T5408 T5404 arg2Of systems,from
R2842 T5408 T5405 arg1Of systems,R
R2843 T5408 T5406 arg1Of systems,&
R2844 T5408 T5407 arg1Of systems,D
R2845 T5410 T5411 arg1Of Minneapolis,","
R2846 T5411 T5409 arg2Of ",",(
R2847 T5411 T5413 arg1Of ",",","
R2848 T5412 T5411 arg2Of MN,","
R2849 T5414 T5413 arg2Of USA,","
R2850 T5415 T5409 arg3Of ),(
R2851 T5421 T5420 arg2Of TGF,(
R2852 T5422 T5420 arg3Of ),(
R2853 T5423 T5416 arg1Of -β,Recombinant
R2854 T5423 T5417 arg1Of -β,transforming
R2855 T5423 T5418 arg1Of -β,growth
R2856 T5423 T5419 arg1Of -β,factor
R2857 T5423 T5420 arg1Of -β,(
R2858 T5423 T5424 arg1Of -β,was
R2859 T5423 T5425 arg2Of -β,purchased
R2860 T5425 T5424 arg2Of purchased,was
R2861 T5425 T5426 arg1Of purchased,from
R2862 T5427 T5426 arg2Of Peprotech,from
R2863 T5427 T5428 arg1Of Peprotech,(
R2864 T5429 T5428 arg2Of London,(
R2865 T5429 T5430 arg1Of London,","
R2866 T5429 T5431 arg1Of London,UK
R2867 T5432 T5428 arg3Of ),(
R2868 T5434 T5435 arg1Of TNF-α,and
R2869 T5435 T5433 arg1Of and,Recombinant
R2870 T5435 T5437 arg1Of and,were
R2871 T5435 T5438 arg2Of and,purchased
R2872 T5436 T5435 arg2Of IL-1,and
R2873 T5438 T5437 arg2Of purchased,were
R2874 T5438 T5439 arg1Of purchased,from
R2875 T5441 T5439 arg2Of Inc.,from
R2876 T5441 T5440 arg1Of Inc.,Endogen
R2877 T5441 T5442 arg1Of Inc.,(
R2878 T5443 T5442 arg2Of Cambridge,(
R2879 T5443 T5444 arg1Of Cambridge,","
R2880 T5443 T5446 arg1Of Cambridge,","
R2881 T5445 T5444 arg2Of MA,","
R2882 T5447 T5446 arg2Of USA,","
R2883 T5448 T5442 arg3Of ),(
R2884 T5450 T5449 arg1Of A,Cyclosporin
R2885 T5450 T5451 arg1Of A,was
R2886 T5450 T5452 arg2Of A,provided
R2887 T5452 T5451 arg2Of provided,was
R2888 T5455 T5452 arg1Of Ltd.,provided
R2889 T5455 T5453 arg2Of Ltd.,by
R2890 T5455 T5454 arg1Of Ltd.,Sandos
R2891 T5455 T5456 arg1Of Ltd.,(
R2892 T5457 T5456 arg2Of Basel,(
R2893 T5457 T5458 arg1Of Basel,","
R2894 T5459 T5458 arg2Of Switzerland,","
R2895 T5460 T5456 arg3Of ),(
R2896 T5461 T5462 arg1Of Phytohemagglutinin,(
R2897 T5461 T5465 arg1Of Phytohemagglutinin,","
R2898 T5463 T5462 arg2Of PHA,(
R2899 T5464 T5462 arg3Of ),(
R2900 T5465 T5471 arg1Of ",",","
R2901 T5467 T5465 arg2Of dithiocarbamate,","
R2902 T5467 T5466 arg1Of dithiocarbamate,pyrrolidine
R2903 T5467 T5468 arg1Of dithiocarbamate,(
R2904 T5469 T5468 arg2Of PDTC,(
R2905 T5470 T5468 arg3Of ),(
R2906 T5471 T5473 arg1Of ",",","
R2907 T5472 T5471 arg2Of rapamycin,","
R2908 T5473 T5475 arg1Of ",",and
R2909 T5474 T5473 arg2Of dexamethasone,","
R2910 T5475 T5477 arg1Of and,were
R2911 T5475 T5479 arg2Of and,obtained
R2912 T5476 T5475 arg2Of curcumin,and
R2913 T5479 T5477 arg2Of obtained,were
R2914 T5479 T5478 arg1Of obtained,all
R2915 T5479 T5480 arg1Of obtained,from
R2916 T5484 T5480 arg2Of Co.,from
R2917 T5484 T5481 arg1Of Co.,the
R2918 T5484 T5482 arg1Of Co.,Sigma
R2919 T5484 T5483 arg1Of Co.,Chemical
R2920 T5484 T5485 arg1Of Co.,(
R2921 T5487 T5485 arg2Of Louis,(
R2922 T5487 T5486 arg1Of Louis,St
R2923 T5487 T5488 arg1Of Louis,","
R2924 T5489 T5488 arg2Of MA,","
R2925 T5489 T5490 arg1Of MA,","
R2926 T5491 T5490 arg2Of USA,","
R2927 T5492 T5485 arg3Of ),(
R2928 T5495 T5493 arg1Of antibody,Anti-CD3
R2929 T5495 T5494 arg1Of antibody,monoclonal
R2930 T5495 T5496 arg1Of antibody,and
R2931 T5496 T5500 arg1Of and,were
R2932 T5496 T5501 arg2Of and,obtained
R2933 T5499 T5496 arg2Of antibody,and
R2934 T5499 T5497 arg1Of antibody,anti-CD28
R2935 T5499 T5498 arg1Of antibody,monoclonal
R2936 T5501 T5500 arg2Of obtained,were
R2937 T5501 T5502 arg1Of obtained,from
R2938 T5504 T5502 arg2Of Biosciences,from
R2939 T5504 T5503 arg1Of Biosciences,BD
R2940 T5504 T5505 arg1Of Biosciences,(
R2941 T5507 T5505 arg2Of Diego,(
R2942 T5507 T5506 arg1Of Diego,San
R2943 T5507 T5508 arg1Of Diego,","
R2944 T5509 T5508 arg2Of CA,","
R2945 T5509 T5510 arg1Of CA,","
R2946 T5511 T5510 arg2Of USA,","
R2947 T5512 T5505 arg3Of ),(
R2948 T5513 T5514 arg1Of LY294002,","
R2949 T5514 T5516 arg1Of ",",","
R2950 T5515 T5514 arg2Of SB203580,","
R2951 T5516 T5518 arg1Of ",",","
R2952 T5517 T5516 arg2Of FK506,","
R2953 T5518 T5520 arg1Of ",",and
R2954 T5519 T5518 arg2Of wortmannin,","
R2955 T5520 T5522 arg1Of and,were
R2956 T5520 T5523 arg2Of and,obtained
R2957 T5521 T5520 arg2Of PD98059,and
R2958 T5523 T5522 arg2Of obtained,were
R2959 T5523 T5524 arg1Of obtained,from
R2960 T5523 T5526 arg1Of obtained,(
R2961 T5525 T5524 arg2Of Calbiochem,from
R2962 T5527 T5526 arg2Of Schwalbach,(
R2963 T5527 T5528 arg1Of Schwalbach,","
R2964 T5529 T5528 arg2Of Germany,","
R2965 T5530 T5526 arg3Of ),(
R3144 T6095 T6096 arg1Of Production,of
R3145 T6095 T6098 arg1Of Production,by
R3146 T6097 T6096 arg2Of IL-17,of
R3147 T6102 T6099 arg1Of activation,T
R3148 T6102 T6100 arg1Of activation,cell
R3149 T6102 T6101 arg1Of activation,receptor
R3150 T6102 T6103 arg1Of activation,","
R3151 T6103 T6105 arg1Of ",",or
R3152 T6104 T6103 arg2Of cytokines,","
R3153 T6105 T6098 arg2Of or,by
R3154 T6106 T6105 arg2Of chemokines,or
R3155 T6107 T6108 arg1Of PBMC,were
R3156 T6107 T6109 arg2Of PBMC,prepared
R3157 T6109 T6108 arg2Of prepared,were
R3158 T6109 T6110 arg1Of prepared,from
R3159 T6112 T6110 arg2Of blood,from
R3160 T6112 T6111 arg2Of blood,heparinized
R3161 T6116 T6115 arg2Of SG1077,(
R3162 T6117 T6115 arg3Of ),(
R3163 T6119 T6109 arg1Of centrifugation,prepared
R3164 T6119 T6113 arg2Of centrifugation,by
R3165 T6119 T6114 arg1Of centrifugation,Ficoll-Hypaque
R3166 T6119 T6115 arg1Of centrifugation,(
R3167 T6119 T6118 arg1Of centrifugation,density-gradient
R3168 T6121 T6120 arg1Of cultures,Cell
R3169 T6121 T6122 arg1Of cultures,were
R3170 T6121 T6123 arg2Of cultures,performed
R3171 T6123 T6122 arg2Of performed,were
R3172 T6123 T6124 arg1Of performed,as
R3173 T6123 T6127 arg1Of performed,[
R3174 T6125 T6124 arg2Of described,as
R3175 T6125 T6126 arg1Of described,previously
R3176 T6128 T6127 arg2Of 18,[
R3177 T6129 T6127 arg3Of ],[
R3178 T6131 T6130 arg2Of brief,In
R3179 T6135 T6133 arg1Of suspensions,the
R3180 T6135 T6134 arg1Of suspensions,cell
R3181 T6135 T6136 arg1Of suspensions,were
R3182 T6135 T6137 arg2Of suspensions,adjusted
R3183 T6137 T6130 arg1Of adjusted,In
R3184 T6137 T6132 arg1Of adjusted,","
R3185 T6137 T6136 arg2Of adjusted,were
R3186 T6137 T6138 arg1Of adjusted,to
R3187 T6140 T6138 arg2Of concentration,to
R3188 T6140 T6139 arg1Of concentration,a
R3189 T6140 T6141 arg1Of concentration,of
R3190 T6140 T6143 arg1Of concentration,in
R3191 T6142 T6141 arg2Of 106/ml,of
R3192 T6146 T6143 arg2Of medium,in
R3193 T6146 T6144 arg1Of medium,RPMI
R3194 T6146 T6145 arg1Of medium,1640
R3195 T6146 T6147 arg2Of medium,supplemented
R3196 T6147 T6148 arg1Of supplemented,with
R3197 T6149 T6150 arg1Of 10,%
R3198 T6153 T6149 arg1Of serum,10
R3199 T6153 T6151 arg1Of serum,fetal
R3200 T6153 T6152 arg1Of serum,calf
R3201 T6153 T6154 arg1Of serum,","
R3202 T6154 T6158 arg1Of ",",","
R3203 T6157 T6154 arg2Of penicillin,","
R3204 T6157 T6155 arg1Of penicillin,100
R3205 T6157 T6156 arg1Of penicillin,U/ml
R3206 T6158 T6162 arg1Of ",",and
R3207 T6159 T6160 arg1Of 100,mg/ml
R3208 T6161 T6158 arg2Of streptomycin,","
R3209 T6161 T6159 arg1Of streptomycin,100
R3210 T6162 T6148 arg2Of and,with
R3211 T6163 T6164 arg1Of 2,mM
R3212 T6165 T6162 arg2Of L-glutamine,and
R3213 T6165 T6163 arg1Of L-glutamine,2
R3214 T6167 T6166 arg1Of suspension,Cell
R3215 T6167 T6168 arg1Of suspension,(
R3216 T6167 T6172 arg1Of suspension,was
R3217 T6167 T6173 arg2Of suspension,dispensed
R3218 T6167 T6187 arg2Of suspension,incubated
R3219 T6170 T6168 arg2Of ml,(
R3220 T6170 T6169 arg1Of ml,1
R3221 T6171 T6168 arg3Of ),(
R3222 T6173 T6174 arg1Of dispensed,into
R3223 T6173 T6178 arg1Of dispensed,(
R3224 T6173 T6186 arg1Of dispensed,and
R3225 T6177 T6174 arg2Of plates,into
R3226 T6177 T6175 arg1Of plates,24-well
R3227 T6177 T6176 arg1Of plates,multi-well
R3228 T6179 T6180 arg1Of Nunc,","
R3229 T6180 T6182 arg1Of ",",","
R3230 T6181 T6180 arg2Of Roskilde,","
R3231 T6182 T6178 arg2Of ",",(
R3232 T6183 T6182 arg2Of Denmark,","
R3233 T6184 T6178 arg3Of ),(
R3234 T6186 T6172 arg2Of and,was
R3235 T6186 T6185 arg1Of and,","
R3236 T6187 T6186 arg2Of incubated,and
R3237 T6187 T6188 arg1Of incubated,for
R3238 T6187 T6191 arg1Of incubated,at
R3239 T6190 T6188 arg2Of hours,for
R3240 T6190 T6189 arg1Of hours,24
R3241 T6192 T6191 arg2Of 37°C,at
R3242 T6192 T6193 arg1Of 37°C,in
R3243 T6194 T6195 arg1Of 5,%
R3244 T6196 T6193 arg2Of CO2,in
R3245 T6196 T6194 arg1Of CO2,5
R3246 T6200 T6199 arg1Of concentrations,various
R3247 T6200 T6201 arg1Of concentrations,of
R3248 T6200 T6208 arg1Of concentrations,were
R3249 T6200 T6209 arg2Of concentrations,added
R3250 T6203 T6201 arg2Of A,of
R3251 T6203 T6202 arg1Of A,cyclosporin
R3252 T6203 T6204 arg1Of A,(
R3253 T6206 T6204 arg2Of ng/ml,(
R3254 T6206 T6205 arg1Of ng/ml,10–500
R3255 T6207 T6204 arg3Of ),(
R3256 T6209 T6208 arg2Of added,were
R3257 T6209 T6210 arg1Of added,to
R3258 T6209 T6213 arg1Of added,and
R3259 T6212 T6210 arg2Of medium,to
R3260 T6212 T6211 arg1Of medium,the
R3261 T6213 T6197 arg1Of and,Subsequently
R3262 T6213 T6198 arg1Of and,","
R3263 T6214 T6215 arg1Of cells,were
R3264 T6214 T6216 arg2Of cells,incubated
R3265 T6216 T6213 arg2Of incubated,and
R3266 T6216 T6215 arg2Of incubated,were
R3267 T6216 T6217 arg1Of incubated,for
R3268 T6219 T6217 arg2Of hours,for
R3269 T6219 T6218 arg1Of hours,24
R3270 T6222 T6220 arg1Of well,To
R3271 T6222 T6221 arg1Of well,each
R3272 T6222 T6223 arg1Of well,was
R3273 T6222 T6224 arg2Of well,added
R3274 T6224 T6223 arg2Of added,was
R3275 T6225 T6226 arg1Of FK506,","
R3276 T6226 T6228 arg1Of ",",","
R3277 T6227 T6226 arg2Of rapamycin,","
R3278 T6228 T6230 arg1Of ",",","
R3279 T6229 T6228 arg2Of curcumin,","
R3280 T6230 T6232 arg1Of ",",","
R3281 T6231 T6230 arg2Of PDTC,","
R3282 T6232 T6234 arg1Of ",",","
R3283 T6233 T6232 arg2Of LY294002,","
R3284 T6234 T6224 arg3Of ",",added
R3285 T6235 T6236 arg1Of SB203580,","
R3286 T6236 T6238 arg1Of ",",","
R3287 T6237 T6236 arg2Of PD98059,","
R3288 T6238 T6240 arg1Of ",",or
R3289 T6239 T6238 arg2Of dexamethasone,","
R3290 T6240 T6234 arg2Of or,","
R3291 T6241 T6240 arg2Of wortmannin,or
R3292 T6243 T6242 arg2Of incubation,After
R3293 T6246 T6244 arg2Of hours,for
R3294 T6246 T6245 arg1Of hours,24
R3295 T6254 T6253 arg1Of media,cell-free
R3296 T6254 T6255 arg1Of media,were
R3297 T6254 T6256 arg2Of media,collected
R3298 T6254 T6258 arg2Of media,stored
R3299 T6256 T6257 arg1Of collected,and
R3300 T6257 T6252 arg1Of and,","
R3301 T6257 T6255 arg2Of and,were
R3302 T6257 T6261 arg1Of and,until
R3303 T6258 T6257 arg2Of stored,and
R3304 T6258 T6259 arg1Of stored,at
R3305 T6260 T6259 arg2Of -20°C,at
R3306 T6262 T6261 arg2Of assayed,until
R3307 T6264 T6263 arg1Of cultures,All
R3308 T6264 T6265 arg1Of cultures,were
R3309 T6264 T6266 arg2Of cultures,set
R3310 T6266 T6265 arg2Of set,were
R3311 T6266 T6267 arg1Of set,up
R3312 T6266 T6268 arg1Of set,in
R3313 T6266 T6271 arg1Of set,and
R3314 T6269 T6268 arg2Of triplicate,in
R3315 T6271 T6270 arg1Of and,","
R3316 T6272 T6273 arg1Of results,are
R3317 T6272 T6274 arg2Of results,expressed
R3318 T6274 T6271 arg2Of expressed,and
R3319 T6274 T6273 arg2Of expressed,are
R3320 T6274 T6275 arg1Of expressed,as
R3321 T6276 T6277 arg1Of means,±
R3322 T6277 T6275 arg2Of ±,as
R3323 T6278 T6277 arg2Of SEM,±
R3527 T6741 T6739 arg1Of isolation,CD4+
R3528 T6741 T6740 arg1Of isolation,T-cell
R3529 T6741 T6742 arg1Of isolation,by
R3530 T6743 T6742 arg2Of MACS,by
R3531 T6745 T6744 arg1Of microbeads,Anti-CD4
R3532 T6745 T6746 arg1Of microbeads,were
R3533 T6745 T6747 arg2Of microbeads,used
R3534 T6747 T6746 arg2Of used,were
R3535 T6747 T6748 arg1Of used,essentially
R3536 T6747 T6749 arg1Of used,as
R3537 T6747 T6757 arg1Of used,[
R3538 T6750 T6749 arg2Of recommended,as
R3539 T6750 T6754 arg1Of recommended,(
R3540 T6753 T6750 arg1Of manufacturer,recommended
R3541 T6753 T6751 arg2Of manufacturer,by
R3542 T6753 T6752 arg1Of manufacturer,the
R3543 T6755 T6754 arg2Of Miltenyi,(
R3544 T6756 T6754 arg3Of ),(
R3545 T6758 T6757 arg2Of 19,[
R3546 T6759 T6757 arg3Of ],[
R3547 T6760 T6761 arg1Of PBMC,were
R3548 T6760 T6762 arg2Of PBMC,resuspended
R3549 T6762 T6761 arg2Of resuspended,were
R3550 T6762 T6763 arg1Of resuspended,in
R3551 T6765 T6763 arg2Of μl,in
R3552 T6765 T6764 arg1Of μl,80
R3553 T6765 T6766 arg1Of μl,of
R3554 T6769 T6766 arg2Of buffer,of
R3555 T6769 T6767 arg1Of buffer,FBS
R3556 T6769 T6768 arg1Of buffer,staining
R3557 T6771 T6770 arg1Of microbeads,Anti-CD4
R3558 T6771 T6772 arg1Of microbeads,(
R3559 T6771 T6776 arg1Of microbeads,were
R3560 T6771 T6777 arg2Of microbeads,added
R3561 T6771 T6779 arg2Of microbeads,incubated
R3562 T6774 T6772 arg2Of μl,(
R3563 T6774 T6773 arg1Of μl,20
R3564 T6775 T6772 arg3Of ),(
R3565 T6777 T6778 arg1Of added,and
R3566 T6778 T6776 arg2Of and,were
R3567 T6779 T6778 arg2Of incubated,and
R3568 T6779 T6780 arg1Of incubated,for
R3569 T6779 T6783 arg1Of incubated,at
R3570 T6782 T6780 arg2Of min,for
R3571 T6782 T6781 arg1Of min,15
R3572 T6784 T6783 arg2Of 6–12°C,at
R3573 T6786 T6785 arg1Of amounts,Saturating
R3574 T6786 T6787 arg1Of amounts,of
R3575 T6786 T6790 arg1Of amounts,were
R3576 T6786 T6791 arg2Of amounts,added
R3577 T6789 T6787 arg2Of antibodies,of
R3578 T6789 T6788 arg1Of antibodies,fluorochrome-conjugated
R3579 T6791 T6790 arg2Of added,were
R3580 T6791 T6792 arg1Of added,for
R3581 T6796 T6792 arg2Of min,for
R3582 T6796 T6793 arg1Of min,a
R3583 T6796 T6794 arg1Of min,further
R3584 T6796 T6795 arg1Of min,10
R3585 T6797 T6798 arg1Of Cells,were
R3586 T6797 T6799 arg2Of Cells,diluted
R3587 T6797 T6810 arg2Of Cells,resuspended
R3588 T6797 T6816 arg2Of Cells,separated
R3589 T6799 T6800 arg1Of diluted,in
R3590 T6799 T6809 arg1Of diluted,","
R3591 T6802 T6800 arg2Of ml,in
R3592 T6802 T6801 arg1Of ml,2.5
R3593 T6802 T6803 arg1Of ml,of
R3594 T6802 T6807 arg1Of ml,","
R3595 T6802 T6808 arg2Of ml,pelleted
R3596 T6806 T6803 arg2Of buffer,of
R3597 T6806 T6804 arg1Of buffer,FBS
R3598 T6806 T6805 arg1Of buffer,staining
R3599 T6809 T6798 arg2Of ",",were
R3600 T6809 T6817 arg1Of ",",","
R3601 T6809 T6819 arg1Of ",",on
R3602 T6810 T6811 arg1Of resuspended,in
R3603 T6810 T6814 arg1Of resuspended,and
R3604 T6813 T6811 arg2Of μl,in
R3605 T6813 T6812 arg1Of μl,500
R3606 T6814 T6809 arg2Of and,","
R3607 T6816 T6814 arg2Of separated,and
R3608 T6816 T6815 arg1Of separated,magnetically
R3609 T6819 T6818 arg1Of on,usually
R3610 T6822 T6819 arg2Of magnet,on
R3611 T6822 T6820 arg1Of magnet,an
R3612 T6822 T6821 arg1Of magnet,AutoMACS
R3613 T6822 T6823 arg2Of magnet,fitted
R3614 T6823 T6824 arg1Of fitted,with
R3615 T6828 T6824 arg2Of column,with
R3616 T6828 T6825 arg1Of column,a
R3617 T6828 T6826 arg1Of column,MACS
R3618 T6828 T6827 arg1Of column,MS
R3619 T6829 T6830 arg1Of Flow-through,and
R3620 T6831 T6830 arg2Of two,and
R3621 T6832 T6829 arg1Of 1,Flow-through
R3622 T6832 T6831 arg1Of 1,two
R3623 T6834 T6832 arg1Of washes,1
R3624 T6834 T6833 arg1Of washes,ml
R3625 T6834 T6835 arg1Of washes,were
R3626 T6834 T6836 arg2Of washes,collected
R3627 T6836 T6835 arg2Of collected,were
R3628 T6836 T6837 arg1Of collected,as
R3629 T6840 T6837 arg2Of fraction,as
R3630 T6840 T6838 arg1Of fraction,the
R3631 T6840 T6839 arg1Of fraction,negative
R3632 T6842 T6841 arg2Of cells,Enriched
R3633 T6842 T6843 arg1Of cells,were
R3634 T6842 T6844 arg2Of cells,collected
R3635 T6844 T6843 arg2Of collected,were
R3636 T6844 T6845 arg1Of collected,in
R3637 T6847 T6846 arg1Of 0.5,two
R3638 T6849 T6845 arg2Of aliquots,in
R3639 T6849 T6847 arg1Of aliquots,0.5
R3640 T6849 T6848 arg1Of aliquots,ml
R3641 T6849 T6850 arg1Of aliquots,from
R3642 T6852 T6850 arg2Of column,from
R3643 T6852 T6851 arg1Of column,the
R3644 T6852 T6853 arg1Of column,after
R3645 T6854 T6853 arg2Of removal,after
R3646 T6854 T6855 arg1Of removal,from
R3647 T6857 T6855 arg2Of magnet,from
R3648 T6857 T6856 arg1Of magnet,the
R3649 T6860 T6861 arg2Of cells,stained
R3650 T6860 T6864 arg1Of cells,were
R3651 T6860 T6865 arg2Of cells,washed
R3652 T6861 T6862 arg1Of stained,with
R3653 T6863 T6862 arg2Of anti-CD4–phycoerythrin,with
R3654 T6865 T6858 arg1Of washed,Alternatively
R3655 T6865 T6859 arg1Of washed,","
R3656 T6865 T6864 arg2Of washed,were
R3657 T6865 T6866 arg1Of washed,","
R3658 T6867 T6865 arg3Of magnetically,washed
R3659 T6867 T6868 arg2Of magnetically,labeled
R3660 T6867 T6891 arg2Of magnetically,separated
R3661 T6868 T6869 arg1Of labeled,with
R3662 T6868 T6889 arg1Of labeled,and
R3663 T6871 T6869 arg2Of microbeads,with
R3664 T6871 T6870 arg1Of microbeads,anti-phycoerythrin
R3665 T6871 T6872 arg1Of microbeads,(
R3666 T6874 T6873 arg1Of μl,20
R3667 T6874 T6875 arg1Of μl,added
R3668 T6875 T6872 arg2Of added,(
R3669 T6875 T6876 arg1Of added,to
R3670 T6878 T6877 arg1Of μl,80
R3671 T6878 T6879 arg1Of μl,of
R3672 T6878 T6882 arg1Of μl,;
R3673 T6881 T6879 arg2Of suspension,of
R3674 T6881 T6880 arg1Of suspension,cell
R3675 T6882 T6876 arg2Of ;,to
R3676 T6884 T6882 arg2Of min,;
R3677 T6884 T6883 arg1Of min,15
R3678 T6884 T6885 arg1Of min,","
R3679 T6886 T6885 arg2Of 6–12°C,","
R3680 T6887 T6872 arg3Of ),(
R3681 T6889 T6888 arg1Of and,","
R3682 T6891 T6889 arg2Of separated,and
R3683 T6891 T6890 arg1Of separated,magnetically
R3684 T6891 T6892 arg1Of separated,as
R3685 T6893 T6892 arg2Of described,as
R3686 T6893 T6894 arg1Of described,above
R3687 T6896 T6895 arg1Of purity,The
R3688 T6896 T6897 arg1Of purity,of
R3689 T6896 T6899 arg1Of purity,was
R3690 T6896 T6900 arg2Of purity,assessed
R3691 T6898 T6897 arg2Of cells,of
R3692 T6900 T6899 arg2Of assessed,was
R3693 T6904 T6900 arg1Of analysis,assessed
R3694 T6904 T6901 arg2Of analysis,by
R3695 T6904 T6902 arg1Of analysis,flow
R3696 T6904 T6903 arg1Of analysis,cytometric
R3697 T6904 T6905 arg1Of analysis,of
R3698 T6907 T6905 arg2Of cells,of
R3699 T6907 T6906 arg2Of cells,stained
R3700 T6907 T6908 arg1Of cells,on
R3701 T6911 T6910 arg1Of Vantage,FACS
R3702 T6912 T6908 arg2Of sorter,on
R3703 T6912 T6909 arg1Of sorter,a
R3704 T6912 T6911 arg1Of sorter,Vantage
R3705 T6915 T6916 arg1Of more,than
R3706 T6917 T6916 arg2Of 97,than
R3707 T6918 T6913 arg1Of %,Most
R3708 T6918 T6914 arg2Of %,(
R3709 T6918 T6915 arg1Of %,more
R3710 T6918 T6920 arg1Of %,of
R3711 T6918 T6924 arg1Of %,had
R3712 T6919 T6914 arg3Of ),(
R3713 T6923 T6920 arg2Of cells,of
R3714 T6923 T6921 arg1Of cells,the
R3715 T6923 T6922 arg2Of cells,isolated
R3716 T6929 T6924 arg2Of marker,had
R3717 T6929 T6925 arg1Of marker,the
R3718 T6929 T6926 arg1Of marker,CD4
R3719 T6929 T6927 arg1Of marker,T
R3720 T6929 T6928 arg1Of marker,cell
R3930 T7512 T7510 arg1Of assay,Enzyme-linked
R3931 T7512 T7511 arg1Of assay,immunosorbent
R3932 T7512 T7513 arg1Of assay,of
R3933 T7514 T7513 arg2Of IL-17,of
R3934 T7515 T7516 arg1Of IL-17,in
R3935 T7515 T7519 arg1Of IL-17,was
R3936 T7515 T7520 arg2Of IL-17,measured
R3937 T7518 T7516 arg2Of supernatants,in
R3938 T7518 T7517 arg1Of supernatants,culture
R3939 T7520 T7519 arg2Of measured,was
R3940 T7520 T7526 arg1Of measured,as
R3941 T7525 T7520 arg1Of assay,measured
R3942 T7525 T7521 arg2Of assay,by
R3943 T7525 T7522 arg1Of assay,sandwich
R3944 T7525 T7523 arg1Of assay,enzyme-linked
R3945 T7525 T7524 arg1Of assay,immunosorbent
R3946 T7527 T7526 arg2Of described,as
R3947 T7527 T7528 arg1Of described,previously
R3948 T7527 T7529 arg1Of described,[
R3949 T7530 T7529 arg2Of 20,[
R3950 T7531 T7529 arg3Of ],[
R3951 T7533 T7532 arg2Of brief,In
R3952 T7537 T7535 arg1Of plate,a
R3953 T7537 T7536 arg1Of plate,96-well
R3954 T7537 T7538 arg1Of plate,(
R3955 T7537 T7541 arg1Of plate,was
R3956 T7537 T7542 arg2Of plate,coated
R3957 T7539 T7538 arg2Of Nunc,(
R3958 T7540 T7538 arg3Of ),(
R3959 T7542 T7532 arg1Of coated,In
R3960 T7542 T7534 arg1Of coated,","
R3961 T7542 T7541 arg2Of coated,was
R3962 T7542 T7543 arg1Of coated,with
R3963 T7547 T7543 arg2Of antibodies,with
R3964 T7547 T7544 arg1Of antibodies,4
R3965 T7547 T7545 arg1Of antibodies,μg/ml
R3966 T7547 T7546 arg1Of antibodies,monoclonal
R3967 T7547 T7548 arg1Of antibodies,against
R3968 T7549 T7548 arg2Of IL-17,against
R3969 T7549 T7550 arg1Of IL-17,(
R3970 T7549 T7556 arg1Of IL-17,at
R3971 T7554 T7550 arg2Of Systems,(
R3972 T7554 T7551 arg1Of Systems,R
R3973 T7554 T7552 arg1Of Systems,&
R3974 T7554 T7553 arg1Of Systems,D
R3975 T7555 T7550 arg3Of ),(
R3976 T7557 T7556 arg2Of 4°C,at
R3977 T7557 T7558 arg1Of 4°C,overnight
R3978 T7560 T7559 arg2Of blocking,After
R3979 T7560 T7561 arg1Of blocking,with
R3980 T7564 T7563 arg1Of %,saline/1
R3981 T7567 T7561 arg2Of albumin,with
R3982 T7567 T7562 arg1Of albumin,phosphate-buffered
R3983 T7567 T7564 arg1Of albumin,%
R3984 T7567 T7565 arg1Of albumin,bovine
R3985 T7567 T7566 arg1Of albumin,serum
R3986 T7567 T7568 arg1Of albumin,(
R3987 T7569 T7568 arg2Of BSA,(
R3988 T7570 T7568 arg3Of ),(
R3989 T7572 T7571 arg1Of %,/0.05
R3990 T7572 T7573 arg1Of %,Tween
R3991 T7572 T7574 arg1Of %,20
R3992 T7572 T7575 arg1Of %,for
R3993 T7572 T7578 arg1Of %,at
R3994 T7572 T7584 arg1Of %,","
R3995 T7577 T7575 arg2Of hours,for
R3996 T7577 T7576 arg1Of hours,2
R3997 T7580 T7578 arg2Of temperature,at
R3998 T7580 T7579 arg1Of temperature,room
R3999 T7580 T7581 arg1Of temperature,(
R4000 T7582 T7581 arg2Of 22–25°C,(
R4001 T7583 T7581 arg3Of ),(
R4002 T7585 T7584 arg2Of test,","
R4003 T7586 T7572 arg1Of samples,%
R4004 T7586 T7585 arg1Of samples,test
R4005 T7586 T7587 arg1Of samples,and
R4006 T7587 T7560 arg1Of and,blocking
R4007 T7587 T7598 arg1Of and,were
R4008 T7587 T7599 arg2Of and,added
R4009 T7587 T7605 arg2Of and,incubated
R4010 T7591 T7587 arg2Of IL-17,and
R4011 T7591 T7588 arg1Of IL-17,the
R4012 T7591 T7589 arg1Of IL-17,standard
R4013 T7591 T7590 arg1Of IL-17,recombinant
R4014 T7591 T7592 arg1Of IL-17,(
R4015 T7596 T7592 arg2Of Systems,(
R4016 T7596 T7593 arg1Of Systems,R
R4017 T7596 T7594 arg1Of Systems,&
R4018 T7596 T7595 arg1Of Systems,D
R4019 T7597 T7592 arg3Of ),(
R4020 T7599 T7600 arg1Of added,to
R4021 T7599 T7604 arg1Of added,and
R4022 T7603 T7600 arg2Of plate,to
R4023 T7603 T7601 arg1Of plate,the
R4024 T7603 T7602 arg1Of plate,96-well
R4025 T7604 T7559 arg1Of and,After
R4026 T7604 T7598 arg2Of and,were
R4027 T7605 T7604 arg2Of incubated,and
R4028 T7605 T7606 arg1Of incubated,at
R4029 T7605 T7609 arg1Of incubated,for
R4030 T7608 T7606 arg2Of temperature,at
R4031 T7608 T7607 arg1Of temperature,room
R4032 T7611 T7609 arg2Of hours,for
R4033 T7611 T7610 arg1Of hours,2
R4034 T7612 T7613 arg1Of Plates,were
R4035 T7612 T7614 arg2Of Plates,washed
R4036 T7612 T7624 arg2Of Plates,incubated
R4037 T7614 T7616 arg1Of washed,times
R4038 T7614 T7622 arg1Of washed,and
R4039 T7616 T7615 arg1Of times,four
R4040 T7616 T7617 arg1Of times,with
R4041 T7619 T7617 arg2Of saline/Tween,with
R4042 T7619 T7618 arg1Of saline/Tween,phosphate-buffered
R4043 T7619 T7620 arg1Of saline/Tween,20
R4044 T7622 T7613 arg2Of and,were
R4045 T7622 T7621 arg1Of and,","
R4046 T7624 T7622 arg2Of incubated,and
R4047 T7624 T7623 arg1Of incubated,then
R4048 T7624 T7625 arg1Of incubated,with
R4049 T7627 T7625 arg2Of ng/ml,with
R4050 T7627 T7626 arg1Of ng/ml,500
R4051 T7627 T7628 arg2Of ng/ml,biotinylated
R4052 T7628 T7640 arg1Of biotinylated,for
R4053 T7631 T7628 arg3Of antibodies,biotinylated
R4054 T7631 T7629 arg1Of antibodies,mouse
R4055 T7631 T7630 arg1Of antibodies,monoclonal
R4056 T7631 T7632 arg1Of antibodies,against
R4057 T7631 T7634 arg1Of antibodies,(
R4058 T7633 T7632 arg2Of IL-17,against
R4059 T7638 T7634 arg2Of Systems,(
R4060 T7638 T7635 arg1Of Systems,R
R4061 T7638 T7636 arg1Of Systems,&
R4062 T7638 T7637 arg1Of Systems,D
R4063 T7639 T7634 arg3Of ),(
R4064 T7642 T7640 arg2Of hours,for
R4065 T7642 T7641 arg1Of hours,2
R4066 T7642 T7643 arg1Of hours,at
R4067 T7645 T7643 arg2Of temperature,at
R4068 T7645 T7644 arg1Of temperature,room
R4069 T7647 T7646 arg2Of washing,After
R4070 T7652 T7649 arg1Of conjugate,streptavidin–alkaline
R4071 T7652 T7650 arg1Of conjugate,phosphate–horseradish
R4072 T7652 T7651 arg1Of conjugate,peroxidase
R4073 T7652 T7653 arg1Of conjugate,(
R4074 T7652 T7656 arg1Of conjugate,was
R4075 T7652 T7657 arg2Of conjugate,incubated
R4076 T7652 T7663 arg1Of conjugate,washed
R4077 T7652 T7666 arg2Of conjugate,incubated
R4078 T7654 T7653 arg2Of Sigma,(
R4079 T7655 T7653 arg3Of ),(
R4080 T7657 T7656 arg2Of incubated,was
R4081 T7657 T7658 arg1Of incubated,for
R4082 T7657 T7661 arg1Of incubated,","
R4083 T7660 T7658 arg2Of hours,for
R4084 T7660 T7659 arg1Of hours,2
R4085 T7661 T7665 arg1Of ",",and
R4086 T7663 T7661 arg2Of washed,","
R4087 T7663 T7662 arg1Of washed,then
R4088 T7663 T7664 arg1Of washed,again
R4089 T7665 T7647 arg2Of and,washing
R4090 T7665 T7648 arg1Of and,","
R4091 T7666 T7665 arg2Of incubated,and
R4092 T7666 T7667 arg1Of incubated,with
R4093 T7669 T7667 arg2Of mg/ml,with
R4094 T7669 T7668 arg1Of mg/ml,1
R4095 T7671 T7647 arg1Of phosphate,washing
R4096 T7671 T7670 arg1Of phosphate,p-nitrophenyl
R4097 T7671 T7672 arg1Of phosphate,(
R4098 T7671 T7675 arg2Of phosphate,dissolved
R4099 T7673 T7672 arg2Of Sigma,(
R4100 T7674 T7672 arg3Of ),(
R4101 T7675 T7646 arg1Of dissolved,After
R4102 T7675 T7676 arg1Of dissolved,in
R4103 T7675 T7681 modOf dissolved,to
R4104 T7677 T7676 arg2Of diethanolamine,in
R4105 T7677 T7678 arg1Of diethanolamine,(
R4106 T7679 T7678 arg2Of Sigma,(
R4107 T7680 T7678 arg3Of ),(
R4108 T7682 T7681 arg1Of develop,to
R4109 T7685 T7682 arg2Of reaction,develop
R4110 T7685 T7683 arg1Of reaction,the
R4111 T7685 T7684 arg1Of reaction,color
R4112 T7687 T7686 arg1Of reaction,The
R4113 T7687 T7688 arg1Of reaction,was
R4114 T7687 T7689 arg2Of reaction,stopped
R4115 T7689 T7688 arg2Of stopped,was
R4116 T7689 T7690 arg1Of stopped,by
R4117 T7689 T7697 arg1Of stopped,and
R4118 T7692 T7690 arg2Of addition,by
R4119 T7692 T7691 arg1Of addition,the
R4120 T7692 T7693 arg1Of addition,of
R4121 T7694 T7695 arg1Of 1,M
R4122 T7696 T7693 arg2Of NaOH,of
R4123 T7696 T7694 arg1Of NaOH,1
R4124 T7700 T7698 arg1Of density,the
R4125 T7700 T7699 arg1Of density,optical
R4126 T7700 T7701 arg1Of density,of
R4127 T7700 T7704 arg1Of density,was
R4128 T7700 T7705 arg2Of density,read
R4129 T7703 T7701 arg2Of well,of
R4130 T7703 T7702 arg1Of well,each
R4131 T7705 T7697 arg2Of read,and
R4132 T7705 T7704 arg2Of read,was
R4133 T7705 T7706 arg1Of read,at
R4134 T7708 T7706 arg2Of nm,at
R4135 T7708 T7707 arg1Of nm,405
R4136 T7711 T7709 arg1Of limit,The
R4137 T7711 T7710 arg1Of limit,lower
R4138 T7711 T7712 arg1Of limit,of
R4139 T7711 T7715 arg1Of limit,was
R4140 T7714 T7712 arg2Of detection,of
R4141 T7714 T7713 arg1Of detection,IL-17
R4142 T7717 T7715 arg2Of pg/ml,was
R4143 T7717 T7716 arg1Of pg/ml,10
R4144 T7720 T7718 arg1Of IL-17,Recombinant
R4145 T7720 T7719 arg1Of IL-17,human
R4146 T7720 T7721 arg2Of IL-17,diluted
R4147 T7720 T7725 arg1Of IL-17,was
R4148 T7720 T7726 arg2Of IL-17,used
R4149 T7720 T7732 arg1Of IL-17,ranging
R4150 T7721 T7722 arg1Of diluted,in
R4151 T7724 T7722 arg2Of medium,in
R4152 T7724 T7723 arg1Of medium,culture
R4153 T7726 T7725 arg2Of used,was
R4154 T7726 T7727 arg1Of used,as
R4155 T7726 T7731 arg1Of used,","
R4156 T7726 T7732 modOf used,ranging
R4157 T7730 T7727 arg2Of standard,as
R4158 T7730 T7728 arg1Of standard,a
R4159 T7730 T7729 arg1Of standard,calibration
R4160 T7732 T7733 arg1Of ranging,from
R4161 T7734 T7733 arg2Of 10,from
R4162 T7737 T7732 arg2Of pg/ml,ranging
R4163 T7737 T7735 arg1Of pg/ml,to
R4164 T7737 T7736 arg1Of pg/ml,2000
R4165 T7740 T7738 arg1Of curve,A
R4166 T7740 T7739 arg1Of curve,standard
R4167 T7740 T7741 arg1Of curve,was
R4168 T7740 T7742 arg2Of curve,drawn
R4169 T7740 T7758 arg2Of curve,used
R4170 T7742 T7743 arg1Of drawn,by
R4171 T7742 T7757 arg1Of drawn,and
R4172 T7744 T7743 arg2Of plotting,by
R4173 T7746 T7744 arg2Of density,plotting
R4174 T7746 T7745 arg1Of density,optical
R4175 T7746 T7747 arg1Of density,against
R4176 T7749 T7747 arg2Of log,against
R4177 T7749 T7748 arg1Of log,the
R4178 T7749 T7750 arg1Of log,of
R4179 T7752 T7750 arg2Of concentration,of
R4180 T7752 T7751 arg1Of concentration,the
R4181 T7752 T7753 arg1Of concentration,of
R4182 T7755 T7753 arg2Of cytokines,of
R4183 T7755 T7754 arg1Of cytokines,recombinant
R4184 T7757 T7741 arg2Of and,was
R4185 T7757 T7756 arg1Of and,","
R4186 T7758 T7757 arg2Of used,and
R4187 T7758 T7759 arg1Of used,for
R4188 T7760 T7759 arg2Of determination,for
R4189 T7760 T7761 arg1Of determination,of
R4190 T7760 T7763 arg1Of determination,in
R4191 T7762 T7761 arg2Of IL-17,of
R4192 T7765 T7763 arg2Of samples,in
R4193 T7765 T7764 arg1Of samples,test
R4834 T9383 T9381 arg1Of analysis,Western
R4835 T9383 T9382 arg1Of analysis,blot
R4836 T9383 T9384 arg1Of analysis,of
R4837 T9385 T9386 arg1Of Akt,","
R4838 T9386 T9389 arg1Of ",",and
R4839 T9388 T9386 arg2Of Akt,","
R4840 T9388 T9387 arg2Of Akt,phosphorylated
R4841 T9389 T9384 arg2Of and,of
R4842 T9390 T9389 arg2Of IκB-α,and
R4843 T9391 T9392 arg1Of PBMC,were
R4844 T9391 T9393 arg2Of PBMC,incubated
R4845 T9393 T9392 arg2Of incubated,were
R4846 T9393 T9394 arg1Of incubated,with
R4847 T9393 T9400 arg1Of incubated,in
R4848 T9395 T9394 arg2Of anti-CD3,with
R4849 T9395 T9396 arg1Of anti-CD3,(
R4850 T9398 T9396 arg2Of μg/ml,(
R4851 T9398 T9397 arg1Of μg/ml,10
R4852 T9399 T9396 arg3Of ),(
R4853 T9402 T9403 arg1Of presence,or
R4854 T9403 T9400 arg2Of or,in
R4855 T9403 T9401 arg1Of or,the
R4856 T9403 T9405 arg1Of or,of
R4857 T9404 T9403 arg2Of absence,or
R4858 T9406 T9405 arg2Of LY294002,of
R4859 T9406 T9407 arg1Of LY294002,(
R4860 T9409 T9407 arg2Of μM,(
R4861 T9409 T9408 arg1Of μM,20
R4862 T9410 T9407 arg3Of ),(
R4863 T9412 T9411 arg2Of incubation,After
R4864 T9412 T9413 arg1Of incubation,for
R4865 T9415 T9413 arg2Of hour,for
R4866 T9415 T9414 arg1Of hour,1
R4867 T9419 T9417 arg1Of lysates,whole
R4868 T9419 T9418 arg1Of lysates,cell
R4869 T9419 T9420 arg1Of lysates,were
R4870 T9419 T9421 arg2Of lysates,prepared
R4871 T9419 T9434 arg2Of lysates,centrifuged
R4872 T9421 T9422 arg1Of prepared,from
R4873 T9421 T9433 arg1Of prepared,and
R4874 T9424 T9423 arg1Of 107,about
R4875 T9425 T9422 arg2Of cells,from
R4876 T9425 T9424 arg1Of cells,107
R4877 T9427 T9421 arg1Of homogenization,prepared
R4878 T9427 T9426 arg2Of homogenization,by
R4879 T9427 T9428 arg1Of homogenization,in
R4880 T9431 T9428 arg2Of buffer,in
R4881 T9431 T9429 arg1Of buffer,the
R4882 T9431 T9430 arg1Of buffer,lysis
R4883 T9433 T9411 arg1Of and,After
R4884 T9433 T9416 arg1Of and,","
R4885 T9433 T9420 arg2Of and,were
R4886 T9433 T9432 arg1Of and,","
R4887 T9434 T9433 arg2Of centrifuged,and
R4888 T9434 T9435 arg1Of centrifuged,at
R4889 T9434 T9442 arg1Of centrifuged,for
R4890 T9437 T9435 arg2Of r.p.m.,at
R4891 T9437 T9436 arg1Of r.p.m.,"14,000"
R4892 T9437 T9438 arg1Of r.p.m.,(
R4893 T9440 T9438 arg2Of g,(
R4894 T9440 T9439 arg1Of g,"19,000"
R4895 T9441 T9438 arg3Of ),(
R4896 T9444 T9442 arg2Of min,for
R4897 T9444 T9443 arg1Of min,15
R4898 T9446 T9445 arg1Of concentrations,Protein
R4899 T9446 T9447 arg1Of concentrations,in
R4900 T9446 T9450 arg1Of concentrations,were
R4901 T9446 T9451 arg2Of concentrations,determined
R4902 T9449 T9447 arg2Of supernatants,in
R4903 T9449 T9448 arg1Of supernatants,the
R4904 T9451 T9450 arg2Of determined,were
R4905 T9451 T9452 arg1Of determined,with
R4906 T9451 T9456 arg1Of determined,(
R4907 T9455 T9452 arg2Of method,with
R4908 T9455 T9453 arg1Of method,the
R4909 T9455 T9454 arg1Of method,Bradford
R4910 T9457 T9458 arg1Of Bio-Rad,","
R4911 T9458 T9460 arg1Of ",",","
R4912 T9459 T9458 arg2Of Hercules,","
R4913 T9460 T9456 arg2Of ",",(
R4914 T9460 T9462 arg1Of ",",","
R4915 T9460 T9463 arg1Of ",",USA
R4916 T9461 T9460 arg2Of CA,","
R4917 T9464 T9456 arg3Of ),(
R4918 T9466 T9465 arg1Of samples,Protein
R4919 T9466 T9467 arg1Of samples,were
R4920 T9466 T9468 arg2Of samples,separated
R4921 T9466 T9474 arg2Of samples,transferred
R4922 T9468 T9473 arg1Of separated,and
R4923 T9470 T9471 arg1Of 10,%
R4924 T9472 T9468 arg1Of SDS–PAGE,separated
R4925 T9472 T9469 arg2Of SDS–PAGE,by
R4926 T9472 T9470 arg1Of SDS–PAGE,10
R4927 T9473 T9467 arg2Of and,were
R4928 T9473 T9479 arg1Of and,(
R4929 T9474 T9473 arg2Of transferred,and
R4930 T9474 T9475 arg1Of transferred,to
R4931 T9478 T9475 arg2Of membrane,to
R4932 T9478 T9476 arg1Of membrane,a
R4933 T9478 T9477 arg1Of membrane,nitrocellulose
R4934 T9482 T9479 arg2Of Biotech,(
R4935 T9482 T9480 arg1Of Biotech,Amersham
R4936 T9482 T9481 arg1Of Biotech,Pharmacia
R4937 T9482 T9483 arg1Of Biotech,","
R4938 T9484 T9483 arg2Of Uppsala,","
R4939 T9484 T9485 arg1Of Uppsala,","
R4940 T9486 T9485 arg2Of Sweden,","
R4941 T9487 T9479 arg3Of ),(
R4942 T9490 T9488 arg2Of hybridization,For
R4943 T9490 T9489 arg1Of hybridization,western
R4944 T9492 T9493 arg1Of membrane,was
R4945 T9492 T9494 arg2Of membrane,preincubated
R4946 T9494 T9493 arg2Of preincubated,was
R4947 T9494 T9495 arg1Of preincubated,with
R4948 T9494 T9515 arg1Of preincubated,for
R4949 T9494 T9524 arg1Of preincubated,","
R4950 T9497 T9496 arg1Of %,0.1
R4951 T9499 T9495 arg2Of milk,with
R4952 T9499 T9497 arg1Of milk,%
R4953 T9499 T9498 arg2Of milk,skimmed
R4954 T9499 T9500 arg1Of milk,in
R4955 T9502 T9500 arg2Of buffer,in
R4956 T9502 T9501 arg1Of buffer,TBS-T
R4957 T9502 T9503 arg1Of buffer,(
R4958 T9502 T9512 arg1Of buffer,at
R4959 T9505 T9504 arg1Of %,0.1
R4960 T9507 T9503 arg2Of 20,(
R4961 T9507 T9505 arg1Of 20,%
R4962 T9507 T9506 arg1Of 20,Tween
R4963 T9507 T9508 arg1Of 20,in
R4964 T9510 T9508 arg2Of saline,in
R4965 T9510 T9509 arg1Of saline,Tris-buffered
R4966 T9511 T9503 arg3Of ),(
R4967 T9514 T9512 arg2Of temperature,at
R4968 T9514 T9513 arg1Of temperature,room
R4969 T9517 T9515 arg2Of hours,for
R4970 T9517 T9516 arg1Of hours,2
R4971 T9517 T9518 arg1Of hours,","
R4972 T9521 T9518 arg2Of antibodies,","
R4973 T9521 T9519 arg1Of antibodies,then
R4974 T9521 T9520 arg1Of antibodies,primary
R4975 T9521 T9522 arg1Of antibodies,against
R4976 T9523 T9522 arg2Of Akt,against
R4977 T9524 T9488 arg1Of ",",For
R4978 T9524 T9491 arg1Of ",",","
R4979 T9524 T9544 arg1Of ",",:
R4980 T9526 T9527 arg1Of Akt,and
R4981 T9527 T9525 arg2Of and,phosphorylated
R4982 T9527 T9529 arg1Of and,(
R4983 T9527 T9542 arg1Of and,diluted
R4984 T9528 T9527 arg2Of IκB-α,and
R4985 T9533 T9529 arg2Of Inc.,(
R4986 T9533 T9530 arg1Of Inc.,Cell
R4987 T9533 T9531 arg1Of Inc.,Signaling
R4988 T9533 T9532 arg1Of Inc.,Technology
R4989 T9533 T9534 arg1Of Inc.,","
R4990 T9533 T9538 arg1Of Inc.,","
R4991 T9533 T9539 arg1Of Inc.,USA
R4992 T9535 T9536 arg1Of Beverly,","
R4993 T9536 T9534 arg2Of ",",","
R4994 T9537 T9536 arg2Of MA,","
R4995 T9540 T9529 arg3Of ),(
R4996 T9542 T9524 arg2Of diluted,","
R4997 T9542 T9541 arg1Of diluted,","
R4998 T9543 T9542 arg2Of 1,diluted
R4999 T9545 T9546 arg1Of 1000,in
R5000 T9545 T9551 arg1Of 1000,were
R5001 T9545 T9552 arg2Of 1000,added
R5002 T9545 T9554 arg2Of 1000,incubated
R5003 T9547 T9548 arg1Of 5,%
R5004 T9549 T9546 arg2Of BSA/TBS-T,in
R5005 T9549 T9547 arg1Of BSA/TBS-T,5
R5006 T9552 T9553 arg1Of added,and
R5007 T9553 T9544 arg2Of and,:
R5008 T9553 T9550 arg1Of and,","
R5009 T9553 T9551 arg2Of and,were
R5010 T9553 T9556 arg1Of and,at
R5011 T9554 T9553 arg2Of incubated,and
R5012 T9554 T9555 arg1Of incubated,overnight
R5013 T9557 T9556 arg2Of 4°C,at
R5014 T9559 T9558 arg2Of washing,After
R5015 T9559 T9562 arg1Of washing,with
R5016 T9561 T9559 arg2Of times,washing
R5017 T9561 T9560 arg1Of times,four
R5018 T9563 T9562 arg2Of TBS-T,with
R5019 T9568 T9559 arg1Of antibodies,washing
R5020 T9568 T9565 arg1Of antibodies,horseradish
R5021 T9568 T9566 arg1Of antibodies,peroxidase-conjugated
R5022 T9568 T9567 arg1Of antibodies,secondary
R5023 T9568 T9569 arg1Of antibodies,were
R5024 T9568 T9570 arg2Of antibodies,added
R5025 T9568 T9572 arg2Of antibodies,allowed
R5026 T9568 T9574 arg1Of antibodies,incubate
R5027 T9570 T9571 arg1Of added,and
R5028 T9571 T9558 arg1Of and,After
R5029 T9571 T9564 arg1Of and,","
R5030 T9571 T9569 arg2Of and,were
R5031 T9572 T9571 arg2Of allowed,and
R5032 T9574 T9572 arg3Of incubate,allowed
R5033 T9574 T9573 arg1Of incubate,to
R5034 T9574 T9575 arg1Of incubate,for
R5035 T9574 T9578 arg1Of incubate,at
R5036 T9577 T9575 arg2Of hour,for
R5037 T9577 T9576 arg1Of hour,1
R5038 T9580 T9578 arg2Of temperature,at
R5039 T9580 T9579 arg1Of temperature,room
R5040 T9583 T9581 arg2Of washing,After
R5041 T9583 T9582 arg1Of washing,TBS-T
R5042 T9586 T9585 arg2Of bands,hybridized
R5043 T9586 T9587 arg1Of bands,were
R5044 T9586 T9588 arg2Of bands,detected
R5045 T9588 T9581 arg1Of detected,After
R5046 T9588 T9584 arg1Of detected,","
R5047 T9588 T9587 arg2Of detected,were
R5048 T9588 T9589 arg1Of detected,with
R5049 T9594 T9593 arg2Of ECL,(
R5050 T9595 T9593 arg3Of ),(
R5051 T9597 T9592 arg1Of kit,chemiluminescence
R5052 T9597 T9593 arg1Of kit,(
R5053 T9597 T9596 arg1Of kit,detection
R5054 T9597 T9598 arg1Of kit,and
R5055 T9598 T9589 arg2Of and,with
R5056 T9598 T9590 arg1Of and,the
R5057 T9598 T9591 arg2Of and,enhanced
R5058 T9600 T9598 arg2Of reagents,and
R5059 T9600 T9599 arg1Of reagents,Hyperfilm-ECL
R5060 T9600 T9601 arg1Of reagents,(
R5061 T9603 T9601 arg2Of Pharmacia,(
R5062 T9603 T9602 arg1Of Pharmacia,Amersham
R5063 T9604 T9601 arg3Of ),(
R5322 T10192 T10190 arg1Of assay,Gel
R5323 T10192 T10191 arg1Of assay,mobility-shift
R5324 T10192 T10193 arg1Of assay,of
R5325 T10196 T10193 arg2Of site,of
R5326 T10196 T10194 arg1Of site,NF-κB
R5327 T10196 T10195 arg1Of site,binding
R5328 T10198 T10197 arg1Of proteins,Nuclear
R5329 T10198 T10199 arg1Of proteins,were
R5330 T10198 T10200 arg2Of proteins,extracted
R5331 T10200 T10199 arg2Of extracted,were
R5332 T10200 T10201 arg1Of extracted,from
R5333 T10203 T10202 arg1Of 5,about
R5334 T10205 T10204 arg1Of 106,×
R5335 T10206 T10201 arg2Of PBMC,from
R5336 T10206 T10203 arg1Of PBMC,5
R5337 T10206 T10205 arg1Of PBMC,106
R5338 T10208 T10207 arg1Of probes,Oligonucleotide
R5339 T10208 T10209 arg1Of probes,encompassing
R5340 T10208 T10230 arg1Of probes,were
R5341 T10208 T10231 arg2Of probes,generated
R5342 T10213 T10209 arg2Of site,encompassing
R5343 T10213 T10210 arg1Of site,the
R5344 T10213 T10211 arg1Of site,NF-κB
R5345 T10213 T10212 arg1Of site,binding
R5346 T10213 T10214 arg1Of site,of
R5347 T10218 T10214 arg2Of promoter,of
R5348 T10218 T10215 arg1Of promoter,the
R5349 T10218 T10216 arg1Of promoter,human
R5350 T10218 T10217 arg1Of promoter,IL-17
R5351 T10218 T10219 arg1Of promoter,(
R5352 T10227 T10219 arg2Of TTC-3,(
R5353 T10227 T10220 arg1Of TTC-3,5'-ATG
R5354 T10227 T10221 arg1Of TTC-3,ACC
R5355 T10227 T10222 arg1Of TTC-3,TGG
R5356 T10227 T10223 arg1Of TTC-3,AAA
R5357 T10227 T10224 arg1Of TTC-3,TAC
R5358 T10227 T10225 arg1Of TTC-3,CCA
R5359 T10227 T10226 arg1Of TTC-3,AAA
R5360 T10227 T10228 arg1Of TTC-3,'
R5361 T10229 T10219 arg3Of ),(
R5362 T10231 T10230 arg2Of generated,were
R5363 T10231 T10232 arg1Of generated,by
R5364 T10231 T10239 arg1Of generated,with
R5365 T10234 T10232 arg2Of labeling,by
R5366 T10234 T10233 arg1Of labeling,5'-end
R5367 T10234 T10235 arg1Of labeling,of
R5368 T10238 T10235 arg2Of strand,of
R5369 T10238 T10236 arg1Of strand,the
R5370 T10238 T10237 arg1Of strand,sense
R5371 T10241 T10240 arg2Of γ-32P,[
R5372 T10242 T10240 arg3Of ],[
R5373 T10243 T10240 arg1Of dATP,[
R5374 T10243 T10244 arg1Of dATP,(
R5375 T10243 T10248 arg1Of dATP,and
R5376 T10246 T10244 arg2Of Pharmacia,(
R5377 T10246 T10245 arg1Of Pharmacia,Amersham
R5378 T10247 T10244 arg3Of ),(
R5379 T10248 T10239 arg2Of and,with
R5380 T10251 T10248 arg2Of kinase,and
R5381 T10251 T10249 arg1Of kinase,T4
R5382 T10251 T10250 arg1Of kinase,polynucleotide
R5383 T10251 T10252 arg1Of kinase,(
R5384 T10253 T10252 arg2Of TaKaRa,(
R5385 T10254 T10252 arg3Of ),(
R5386 T10256 T10255 arg1Of nucleotides,Unincorporated
R5387 T10256 T10257 arg1Of nucleotides,were
R5388 T10256 T10258 arg2Of nucleotides,removed
R5389 T10258 T10257 arg2Of removed,were
R5390 T10263 T10258 arg1Of columns,removed
R5391 T10263 T10259 arg2Of columns,by
R5392 T10263 T10260 arg1Of columns,NucTrap
R5393 T10263 T10261 arg1Of columns,probe
R5394 T10263 T10262 arg1Of columns,purification
R5395 T10263 T10264 arg1Of columns,(
R5396 T10265 T10266 arg1Of Stratagene,","
R5397 T10266 T10269 arg1Of ",",","
R5398 T10268 T10266 arg2Of Jolla,","
R5399 T10268 T10267 arg1Of Jolla,La
R5400 T10269 T10264 arg2Of ",",(
R5401 T10269 T10271 arg1Of ",",","
R5402 T10270 T10269 arg2Of CA,","
R5403 T10272 T10271 arg2Of USA,","
R5404 T10273 T10264 arg3Of ),(
R5405 T10275 T10274 arg1Of extracts,Nuclear
R5406 T10275 T10276 arg1Of extracts,(
R5407 T10275 T10282 arg1Of extracts,were
R5408 T10275 T10283 arg2Of extracts,incubated
R5409 T10278 T10276 arg2Of μg,(
R5410 T10278 T10277 arg1Of μg,2
R5411 T10278 T10279 arg1Of μg,of
R5412 T10280 T10279 arg2Of protein,of
R5413 T10281 T10276 arg3Of ),(
R5414 T10283 T10282 arg2Of incubated,were
R5415 T10283 T10284 arg1Of incubated,with
R5416 T10283 T10295 arg1Of incubated,for
R5417 T10287 T10284 arg2Of probes,with
R5418 T10287 T10285 arg2Of probes,radiolabeled
R5419 T10287 T10286 arg1Of probes,DNA
R5420 T10287 T10288 arg1Of probes,(
R5421 T10290 T10289 arg1Of ng,10
R5422 T10290 T10291 arg1Of ng,;
R5423 T10291 T10288 arg2Of ;,(
R5424 T10293 T10291 arg2Of c.p.m.,;
R5425 T10293 T10292 arg1Of c.p.m.,"100,000"
R5426 T10294 T10288 arg3Of ),(
R5427 T10297 T10295 arg2Of min,for
R5428 T10297 T10296 arg1Of min,30
R5429 T10297 T10298 arg1Of min,at
R5430 T10297 T10301 arg1Of min,in
R5431 T10297 T10307 arg1Of min,consisting
R5432 T10297 T10323 arg1Of min,","
R5433 T10300 T10298 arg2Of temperature,at
R5434 T10300 T10299 arg1Of temperature,room
R5435 T10303 T10301 arg2Of μl,in
R5436 T10303 T10302 arg1Of μl,20
R5437 T10303 T10304 arg1Of μl,of
R5438 T10306 T10304 arg2Of buffer,of
R5439 T10306 T10305 arg1Of buffer,binding
R5440 T10307 T10308 arg1Of consisting,of
R5441 T10309 T10310 arg1Of 20,mM
R5442 T10311 T10309 arg1Of Tris-HCl,20
R5443 T10311 T10312 arg1Of Tris-HCl,","
R5444 T10312 T10315 arg1Of ",",","
R5445 T10313 T10312 arg2Of pH,","
R5446 T10313 T10314 arg1Of pH,7.9
R5447 T10315 T10319 arg1Of ",",","
R5448 T10316 T10317 arg1Of 50,mM
R5449 T10318 T10315 arg2Of KCl,","
R5450 T10318 T10316 arg1Of KCl,50
R5451 T10319 T10308 arg2Of ",",of
R5452 T10320 T10321 arg1Of 1,mM
R5453 T10322 T10319 arg2Of dithiothreitol,","
R5454 T10322 T10320 arg1Of dithiothreitol,1
R5455 T10324 T10325 arg1Of 0.5,mM
R5456 T10326 T10324 arg1Of EDTA,0.5
R5457 T10326 T10327 arg1Of EDTA,","
R5458 T10327 T10331 arg1Of ",",","
R5459 T10328 T10329 arg1Of 5,%
R5460 T10330 T10327 arg2Of glycerol,","
R5461 T10330 T10328 arg1Of glycerol,5
R5462 T10331 T10335 arg1Of ",",","
R5463 T10334 T10331 arg2Of BSA,","
R5464 T10334 T10332 arg1Of BSA,1
R5465 T10334 T10333 arg1Of BSA,mg/ml
R5466 T10335 T10340 arg1Of ",",and
R5467 T10336 T10337 arg1Of 0.2,%
R5468 T10339 T10335 arg2Of P40,","
R5469 T10339 T10336 arg1Of P40,0.2
R5470 T10339 T10338 arg1Of P40,Nonidet
R5471 T10340 T10323 arg2Of and,","
R5472 T10343 T10340 arg2Of poly,and
R5473 T10343 T10341 arg1Of poly,50
R5474 T10343 T10342 arg1Of poly,ng/μl
R5475 T10343 T10344 arg1Of poly,(
R5476 T10345 T10344 arg2Of dI-dC,(
R5477 T10346 T10344 arg3Of ),(
R5478 T10347 T10348 arg1Of Samples,were
R5479 T10347 T10349 arg2Of Samples,subjected
R5480 T10349 T10348 arg2Of subjected,were
R5481 T10349 T10350 arg1Of subjected,to
R5482 T10349 T10352 arg1Of subjected,on
R5483 T10351 T10350 arg2Of electrophoresis,to
R5484 T10354 T10355 arg1Of 5,%
R5485 T10357 T10353 arg1Of gels,nondenaturing
R5486 T10357 T10354 arg1Of gels,5
R5487 T10357 T10356 arg1Of gels,polyacrylamide
R5488 T10357 T10358 arg1Of gels,in
R5489 T10357 T10371 arg1Of gels,were
R5490 T10357 T10372 arg2Of gels,dried
R5491 T10357 T10376 arg2Of gels,exposed
R5492 T10362 T10358 arg2Of buffer,in
R5493 T10362 T10359 arg1Of buffer,0.5
R5494 T10362 T10360 arg1Of buffer,×
R5495 T10362 T10361 arg1Of buffer,Tris-borate-EDTA
R5496 T10362 T10363 arg1Of buffer,(
R5497 T10362 T10367 arg1Of buffer,at
R5498 T10364 T10363 arg2Of pH,(
R5499 T10364 T10365 arg1Of pH,8.0
R5500 T10366 T10363 arg3Of ),(
R5501 T10370 T10367 arg2Of Gels,at
R5502 T10370 T10368 arg1Of Gels,100
R5503 T10370 T10369 arg1Of Gels,V.
R5504 T10372 T10373 arg1Of dried,under
R5505 T10372 T10375 arg1Of dried,and
R5506 T10374 T10373 arg2Of vacuum,under
R5507 T10375 T10352 arg2Of and,on
R5508 T10375 T10371 arg2Of and,were
R5509 T10376 T10375 arg2Of exposed,and
R5510 T10376 T10377 modOf exposed,to
R5511 T10378 T10377 arg1Of Kodak,to
R5512 T10378 T10381 arg1Of Kodak,at
R5513 T10380 T10378 arg2Of film,Kodak
R5514 T10380 T10379 arg1Of film,X-OMAT
R5515 T10382 T10381 arg2Of -70°C,at
R5516 T10382 T10383 arg1Of -70°C,with
R5517 T10385 T10383 arg2Of screens,with
R5518 T10385 T10384 arg1Of screens,intensifying
R5519 T10388 T10386 arg1Of antibodies,Rabbit
R5520 T10388 T10387 arg1Of antibodies,polyclonal
R5521 T10388 T10389 arg1Of antibodies,against
R5522 T10388 T10397 arg1Of antibodies,were
R5523 T10388 T10398 arg1Of antibodies,from
R5524 T10391 T10390 arg1Of subunits,NF-κB
R5525 T10392 T10393 arg1Of p50,","
R5526 T10393 T10395 arg1Of ",",and
R5527 T10394 T10393 arg2Of p65,","
R5528 T10395 T10389 arg2Of and,against
R5529 T10395 T10391 arg1Of and,subunits
R5530 T10396 T10395 arg2Of c-Rel,and
R5531 T10398 T10397 arg2Of from,were
R5532 T10401 T10398 arg2Of Biotechnology,from
R5533 T10401 T10399 arg1Of Biotechnology,Santa
R5534 T10401 T10400 arg1Of Biotechnology,Cruz
R5535 T10401 T10402 arg1Of Biotechnology,(
R5536 T10404 T10402 arg2Of Cruz,(
R5537 T10404 T10403 arg1Of Cruz,Santa
R5538 T10404 T10405 arg1Of Cruz,","
R5539 T10406 T10405 arg2Of CA,","
R5540 T10406 T10407 arg1Of CA,","
R5541 T10408 T10407 arg2Of USA,","
R5542 T10409 T10402 arg3Of ),(
R5784 T10826 T10825 arg1Of viability,Cell
R5785 T10826 T10827 arg1Of viability,(
R5786 T10832 T10827 arg2Of assay,(
R5787 T10832 T10828 arg1Of assay,Trypan
R5788 T10832 T10829 arg1Of assay,blue
R5789 T10832 T10830 arg1Of assay,dye
R5790 T10832 T10831 arg1Of assay,exclusion
R5791 T10833 T10827 arg3Of ),(
R5792 T10837 T10834 arg2Of assays,For
R5793 T10837 T10835 arg1Of assays,cell
R5794 T10837 T10836 arg1Of assays,viability
R5795 T10844 T10839 arg1Of method,the
R5796 T10844 T10840 arg1Of method,trypan
R5797 T10844 T10841 arg1Of method,blue
R5798 T10844 T10842 arg1Of method,dye
R5799 T10844 T10843 arg1Of method,exclusion
R5800 T10844 T10845 arg1Of method,was
R5801 T10844 T10846 arg2Of method,used
R5802 T10846 T10834 arg1Of used,For
R5803 T10846 T10838 arg1Of used,","
R5804 T10846 T10845 arg2Of used,was
R5805 T10848 T10846 arg3Of evaluate,used
R5806 T10848 T10847 arg1Of evaluate,to
R5807 T10850 T10848 arg2Of potential,evaluate
R5808 T10850 T10849 arg1Of potential,the
R5809 T10850 T10851 arg1Of potential,of
R5810 T10854 T10851 arg2Of effect,of
R5811 T10854 T10852 arg1Of effect,direct
R5812 T10854 T10853 arg1Of effect,cytotoxic
R5813 T10854 T10855 arg1Of effect,of
R5814 T10854 T10857 arg1Of effect,on
R5815 T10856 T10855 arg2Of inhibitors,of
R5816 T10858 T10857 arg2Of cells,on
R5817 T10860 T10859 arg2Of incubation,After
R5818 T10860 T10861 arg1Of incubation,for
R5819 T10863 T10861 arg2Of hours,for
R5820 T10863 T10862 arg1Of hours,24
R5821 T10866 T10865 arg1Of cells,the
R5822 T10866 T10867 arg1Of cells,were
R5823 T10866 T10868 arg2Of cells,harvested
R5824 T10868 T10867 arg2Of harvested,were
R5825 T10868 T10869 arg1Of harvested,and
R5826 T10869 T10859 arg1Of and,After
R5827 T10869 T10864 arg1Of and,","
R5828 T10873 T10870 arg1Of viability,the
R5829 T10873 T10871 arg1Of viability,percentage
R5830 T10873 T10872 arg1Of viability,cell
R5831 T10873 T10874 arg1Of viability,was
R5832 T10873 T10875 arg2Of viability,calculated
R5833 T10875 T10869 arg2Of calculated,and
R5834 T10875 T10874 arg2Of calculated,was
R5835 T10875 T10876 arg1Of calculated,with
R5836 T10875 T10893 arg1Of calculated,[
R5837 T10880 T10876 arg2Of ×,with
R5838 T10880 T10877 arg1Of ×,the
R5839 T10880 T10878 arg1Of ×,formula
R5840 T10880 T10879 arg1Of ×,100
R5841 T10880 T10881 arg1Of ×,(
R5842 T10882 T10881 arg2Of number,(
R5843 T10882 T10883 arg1Of number,of
R5844 T10885 T10883 arg2Of cells/number,of
R5845 T10885 T10884 arg1Of cells/number,viable
R5846 T10885 T10886 arg1Of cells/number,of
R5847 T10888 T10889 arg1Of viable,and
R5848 T10889 T10887 arg1Of and,both
R5849 T10890 T10889 arg2Of dead,and
R5850 T10891 T10886 arg2Of cells,of
R5851 T10891 T10888 arg1Of cells,viable
R5852 T10891 T10890 arg1Of cells,dead
R5853 T10892 T10881 arg3Of ),(
R5854 T10894 T10893 arg2Of 21,[
R5855 T10895 T10893 arg3Of ],[
R5929 T11019 T11018 arg1Of analysis,Statistical
R5930 T11020 T11021 arg1Of Data,are
R5931 T11020 T11022 arg2Of Data,expressed
R5932 T11022 T11021 arg2Of expressed,are
R5933 T11022 T11023 arg1Of expressed,as
R5934 T11024 T11025 arg1Of means,±
R5935 T11025 T11023 arg2Of ±,as
R5936 T11026 T11025 arg2Of SEM,±
R5937 T11028 T11027 arg1Of analysis,Statistical
R5938 T11028 T11029 arg1Of analysis,was
R5939 T11028 T11030 arg2Of analysis,performed
R5940 T11030 T11029 arg2Of performed,was
R5941 T11030 T11031 arg1Of performed,with
R5942 T11032 T11033 arg2Of Student,'s
R5943 T11034 T11031 arg2Of t-test,with
R5944 T11034 T11033 arg1Of t-test,'s
R5945 T11034 T11035 arg1Of t-test,for
R5946 T11037 T11035 arg2Of pairs,for
R5947 T11037 T11036 arg1Of pairs,matched
R5948 T11039 T11038 arg1Of values,P
R5949 T11039 T11040 arg1Of values,less
R5950 T11039 T11043 arg1Of values,were
R5951 T11039 T11044 arg2Of values,considered
R5952 T11039 T11045 arg1Of values,significant
R5953 T11040 T11041 arg1Of less,than
R5954 T11042 T11041 arg2Of 0.05,than
R5955 T11044 T11043 arg2Of considered,were
R5956 T11045 T11044 arg3Of significant,considered
R6007 T11243 T11242 arg1Of production,IL-17
R6008 T11243 T11244 arg1Of production,in
R6009 T11243 T11246 arg1Of production,from
R6010 T11245 T11244 arg2Of PBMC,in
R6011 T11247 T11246 arg2Of patients,from
R6012 T11247 T11248 arg1Of patients,with
R6013 T11249 T11250 arg1Of RA,","
R6014 T11250 T11254 arg1Of ",",and
R6015 T11251 T11250 arg2Of patients,","
R6016 T11251 T11252 arg1Of patients,with
R6017 T11253 T11252 arg2Of OA,with
R6018 T11254 T11248 arg2Of and,with
R6019 T11256 T11254 arg2Of individuals,and
R6020 T11256 T11255 arg1Of individuals,normal
R6021 T11257 T11258 arg1Of PBMC,were
R6022 T11257 T11259 arg2Of PBMC,separated
R6023 T11257 T11261 arg2Of PBMC,cultured
R6024 T11259 T11260 arg1Of separated,and
R6025 T11260 T11258 arg2Of and,were
R6026 T11260 T11262 arg1Of and,with
R6027 T11260 T11281 arg1Of and,;
R6028 T11261 T11260 arg2Of cultured,and
R6029 T11263 T11262 arg2Of PHA,with
R6030 T11263 T11264 arg1Of PHA,(
R6031 T11263 T11268 arg1Of PHA,from
R6032 T11266 T11264 arg2Of μg/ml,(
R6033 T11266 T11265 arg1Of μg/ml,5
R6034 T11267 T11264 arg3Of ),(
R6035 T11269 T11270 arg1Of patients,with
R6036 T11269 T11272 arg1Of patients,","
R6037 T11271 T11270 arg2Of RA,with
R6038 T11272 T11277 arg1Of ",",and
R6039 T11273 T11272 arg2Of patients,","
R6040 T11273 T11274 arg1Of patients,with
R6041 T11275 T11274 arg2Of OA,with
R6042 T11277 T11268 arg2Of and,from
R6043 T11277 T11276 arg1Of and,","
R6044 T11280 T11277 arg2Of controls,and
R6045 T11280 T11278 arg1Of controls,age-matched
R6046 T11280 T11279 arg1Of controls,normal
R6047 T11283 T11282 arg1Of levels,IL-17
R6048 T11283 T11284 arg1Of levels,were
R6049 T11283 T11286 arg2Of levels,determined
R6050 T11286 T11281 arg2Of determined,;
R6051 T11286 T11284 arg2Of determined,were
R6052 T11286 T11285 arg1Of determined,then
R6053 T11286 T11287 arg1Of determined,in
R6054 T11290 T11287 arg2Of supernatants,in
R6055 T11290 T11288 arg1Of supernatants,the
R6056 T11290 T11289 arg1Of supernatants,culture
R6057 T11290 T11291 arg1Of supernatants,(
R6058 T11292 T11291 arg2Of Fig.,(
R6059 T11292 T11293 arg1Of Fig.,1
R6060 T11294 T11291 arg3Of ),(
R6061 T11297 T11296 arg1Of amounts,the
R6062 T11297 T11298 arg1Of amounts,of
R6063 T11297 T11302 arg1Of amounts,were
R6064 T11297 T11304 arg1Of amounts,different
R6065 T11301 T11298 arg2Of secretion,of
R6066 T11301 T11299 arg1Of secretion,basal
R6067 T11301 T11300 arg1Of secretion,IL-17
R6068 T11302 T11295 arg2Of were,Although
R6069 T11302 T11303 arg1Of were,not
R6070 T11304 T11302 arg2Of different,were
R6071 T11304 T11305 arg1Of different,between
R6072 T11306 T11307 arg1Of RA,","
R6073 T11307 T11309 arg1Of ",",and
R6074 T11308 T11307 arg2Of OA,","
R6075 T11309 T11305 arg2Of and,between
R6076 T11309 T11312 arg1Of and,(
R6077 T11311 T11309 arg2Of controls,and
R6078 T11311 T11310 arg1Of controls,normal
R6079 T11314 T11313 arg1Of ±,62
R6080 T11315 T11316 arg1Of 31,","
R6081 T11317 T11316 arg2Of 43,","
R6082 T11319 T11320 arg1Of 19,and
R6083 T11321 T11320 arg2Of 43,and
R6084 T11323 T11322 arg1Of 10,±
R6085 T11324 T11312 arg2Of pg/ml,(
R6086 T11324 T11314 arg1Of pg/ml,±
R6087 T11324 T11315 arg1Of pg/ml,31
R6088 T11324 T11317 arg1Of pg/ml,43
R6089 T11324 T11318 arg1Of pg/ml,±
R6090 T11324 T11319 arg1Of pg/ml,19
R6091 T11324 T11321 arg1Of pg/ml,43
R6092 T11324 T11323 arg1Of pg/ml,10
R6093 T11324 T11325 arg1Of pg/ml,","
R6094 T11324 T11326 arg1Of pg/ml,respectively
R6095 T11327 T11312 arg3Of ),(
R6096 T11331 T11329 arg1Of production,the
R6097 T11331 T11330 arg1Of production,IL-17
R6098 T11331 T11332 arg2Of production,stimulated
R6099 T11331 T11335 arg1Of production,was
R6100 T11331 T11337 arg1Of production,higher
R6101 T11334 T11332 arg1Of PHA,stimulated
R6102 T11334 T11333 arg2Of PHA,by
R6103 T11335 T11295 arg1Of was,Although
R6104 T11335 T11328 arg1Of was,","
R6105 T11337 T11335 arg2Of higher,was
R6106 T11337 T11336 arg1Of higher,significantly
R6107 T11337 T11338 arg1Of higher,in
R6108 T11337 T11341 arg1Of higher,than
R6109 T11340 T11338 arg2Of PBMC,in
R6110 T11340 T11339 arg1Of PBMC,RA
R6111 T11342 T11341 arg2Of in,than
R6112 T11343 T11342 arg2Of those,in
R6113 T11343 T11344 arg1Of those,from
R6114 T11345 T11346 arg1Of OA,and
R6115 T11346 T11344 arg2Of and,from
R6116 T11347 T11346 arg2Of controls,and
R6117 T11347 T11348 arg1Of controls,(
R6118 T11355 T11352 arg1Of 211,versus
R6119 T11355 T11353 arg1Of 211,463
R6120 T11355 T11354 arg1Of 211,±
R6121 T11356 T11349 arg1Of pg/ml,768
R6122 T11356 T11350 arg1Of pg/ml,±
R6123 T11356 T11351 arg1Of pg/ml,295
R6124 T11356 T11355 arg1Of pg/ml,211
R6125 T11356 T11357 arg1Of pg/ml,[
R6126 T11356 T11362 arg1Of pg/ml,and
R6127 T11358 T11357 arg2Of P,[
R6128 T11358 T11359 arg1Of P,<
R6129 T11358 T11360 arg1Of P,0.05
R6130 T11361 T11357 arg3Of ],[
R6131 T11362 T11348 arg2Of and,(
R6132 T11365 T11364 arg1Of 29,±
R6133 T11366 T11362 arg2Of pg/ml,and
R6134 T11366 T11363 arg1Of pg/ml,241
R6135 T11366 T11365 arg1Of pg/ml,29
R6136 T11366 T11367 arg1Of pg/ml,[
R6137 T11368 T11367 arg2Of P,[
R6138 T11368 T11369 arg1Of P,<
R6139 T11368 T11370 arg1Of P,0.001
R6140 T11371 T11367 arg3Of ],[
R6141 T11372 T11348 arg3Of ),(
R6340 T11797 T11795 arg2Of production,Increased
R6341 T11797 T11796 arg1Of production,IL-17
R6342 T11797 T11798 arg1Of production,in
R6343 T11797 T11804 arg1Of production,by
R6344 T11799 T11798 arg2Of PBMC,in
R6345 T11799 T11800 arg1Of PBMC,of
R6346 T11801 T11800 arg2Of patients,of
R6347 T11801 T11802 arg1Of patients,with
R6348 T11803 T11802 arg2Of RA,with
R6349 T11805 T11806 arg1Of anti-CD3,and/or
R6350 T11806 T11809 arg1Of and/or,and
R6351 T11807 T11806 arg2Of anti-CD28,and/or
R6352 T11809 T11804 arg2Of and,by
R6353 T11809 T11808 arg1Of and,","
R6354 T11810 T11809 arg2Of PHA,and
R6355 T11812 T11813 arg1Of IL-17,was
R6356 T11812 T11815 arg2Of IL-17,known
R6357 T11815 T11811 arg2Of known,Because
R6358 T11815 T11813 arg2Of known,was
R6359 T11815 T11814 arg1Of known,already
R6360 T11815 T11816 arg1Of known,from
R6361 T11818 T11816 arg2Of reports,from
R6362 T11818 T11817 arg1Of reports,earlier
R6363 T11818 T11819 modOf reports,to
R6364 T11818 T11820 arg1Of reports,be
R6365 T11818 T11821 arg2Of reports,produced
R6366 T11821 T11819 arg1Of produced,to
R6367 T11821 T11820 arg2Of produced,be
R6368 T11821 T11822 arg1Of produced,mainly
R6369 T11826 T11821 arg1Of cells,produced
R6370 T11826 T11823 arg2Of cells,by
R6371 T11826 T11824 arg2Of cells,activated
R6372 T11826 T11825 arg1Of cells,T
R6373 T11828 T11829 arg1Of we,investigated
R6374 T11829 T11811 arg1Of investigated,Because
R6375 T11829 T11827 arg1Of investigated,","
R6376 T11829 T11845 arg1Of investigated,as
R6377 T11831 T11829 arg2Of effect,investigated
R6378 T11831 T11830 arg1Of effect,the
R6379 T11831 T11832 arg1Of effect,of
R6380 T11834 T11832 arg2Of concentrations,of
R6381 T11834 T11833 arg1Of concentrations,different
R6382 T11834 T11835 arg1Of concentrations,of
R6383 T11834 T11837 arg1Of concentrations,(
R6384 T11836 T11835 arg2Of anti-CD3,of
R6385 T11838 T11839 arg1Of 1,","
R6386 T11839 T11841 arg1Of ",",and
R6387 T11840 T11839 arg2Of 5,","
R6388 T11842 T11841 arg2Of 10,and
R6389 T11843 T11837 arg2Of μg/ml,(
R6390 T11843 T11838 arg1Of μg/ml,1
R6391 T11843 T11840 arg1Of μg/ml,5
R6392 T11843 T11842 arg1Of μg/ml,10
R6393 T11844 T11837 arg3Of ),(
R6394 T11849 T11845 arg2Of activation,as
R6395 T11849 T11846 arg1Of activation,a
R6396 T11849 T11847 arg1Of activation,T
R6397 T11849 T11848 arg1Of activation,cell
R6398 T11849 T11850 arg1Of activation,","
R6399 T11849 T11851 arg1Of activation,which
R6400 T11849 T11852 arg1Of activation,showed
R6401 T11855 T11852 arg2Of increase,showed
R6402 T11855 T11853 arg1Of increase,a
R6403 T11855 T11854 arg1Of increase,dose-dependent
R6404 T11855 T11856 arg1Of increase,in
R6405 T11858 T11856 arg2Of levels,in
R6406 T11858 T11857 arg1Of levels,IL-17
R6407 T11858 T11859 arg1Of levels,(
R6408 T11860 T11859 arg2Of data,(
R6409 T11860 T11862 arg2Of data,shown
R6410 T11862 T11861 arg1Of shown,not
R6411 T11863 T11859 arg3Of ),(
R6412 T11866 T11864 arg2Of basis,On
R6413 T11866 T11865 arg1Of basis,the
R6414 T11866 T11867 arg1Of basis,of
R6415 T11868 T11867 arg2Of this,of
R6416 T11870 T11871 arg1Of we,chose
R6417 T11871 T11864 arg1Of chose,On
R6418 T11871 T11869 arg1Of chose,","
R6419 T11871 T11874 arg1Of chose,as
R6420 T11873 T11871 arg2Of μg/ml,chose
R6421 T11873 T11872 arg1Of μg/ml,10
R6422 T11877 T11874 arg2Of concentration,as
R6423 T11877 T11875 arg1Of concentration,a
R6424 T11877 T11876 arg1Of concentration,stimulation
R6425 T11877 T11878 arg1Of concentration,for
R6426 T11879 T11878 arg2Of anti-CD3,for
R6427 T11881 T11880 arg2Of shown,As
R6428 T11881 T11882 arg1Of shown,in
R6429 T11884 T11882 arg2Of 1,in
R6430 T11884 T11883 arg1Of 1,Table
R6431 T11886 T11888 arg1Of anti-CD3,upregulated
R6432 T11888 T11880 arg1Of upregulated,As
R6433 T11888 T11885 arg1Of upregulated,","
R6434 T11888 T11887 arg1Of upregulated,significantly
R6435 T11888 T11895 arg1Of upregulated,and
R6436 T11890 T11888 arg2Of production,upregulated
R6437 T11890 T11889 arg1Of production,IL-17
R6438 T11890 T11892 arg1Of production,to
R6439 T11892 T11891 arg1Of to,up
R6440 T11893 T11892 arg2Of 3.7-fold,to
R6441 T11895 T11894 arg1Of and,","
R6442 T11897 T11896 arg1Of combination,the
R6443 T11897 T11898 arg1Of combination,of
R6444 T11897 T11902 arg1Of combination,produced
R6445 T11899 T11900 arg1Of anti-CD28,and
R6446 T11900 T11898 arg2Of and,of
R6447 T11901 T11900 arg2Of anti-CD3,and
R6448 T11902 T11895 arg2Of produced,and
R6449 T11902 T11905 arg1Of produced,(
R6450 T11902 T11909 arg1Of produced,than
R6451 T11904 T11902 arg2Of IL-17,produced
R6452 T11904 T11903 arg1Of IL-17,more
R6453 T11907 T11905 arg2Of 1.3-1.5-fold,(
R6454 T11907 T11906 arg1Of 1.3-1.5-fold,approximately
R6455 T11908 T11905 arg3Of ),(
R6456 T11910 T11909 arg2Of anti-CD3,than
R6457 T11910 T11911 arg1Of anti-CD3,alone
R6458 T11915 T11914 arg2Of incubated,when
R6459 T11915 T11916 arg1Of incubated,with
R6460 T11919 T11916 arg2Of mitogens,with
R6461 T11919 T11917 arg1Of mitogens,T
R6462 T11919 T11918 arg1Of mitogens,cell
R6463 T11919 T11921 arg1Of mitogens,as
R6464 T11921 T11920 arg1Of as,such
R6465 T11922 T11921 arg2Of PHA,as
R6466 T11926 T11915 arg1Of production,incubated
R6467 T11926 T11924 arg2Of production,increased
R6468 T11926 T11925 arg1Of production,IL-17
R6469 T11926 T11927 arg1Of production,was
R6470 T11926 T11929 arg1Of production,pronounced
R6471 T11927 T11912 arg1Of was,Furthermore
R6472 T11927 T11913 arg1Of was,","
R6473 T11927 T11914 arg1Of was,when
R6474 T11927 T11923 arg1Of was,","
R6475 T11929 T11927 arg2Of pronounced,was
R6476 T11929 T11928 arg1Of pronounced,more
R6477 T11929 T11930 arg1Of pronounced,than
R6478 T11929 T11935 arg1Of pronounced,(
R6479 T11931 T11930 arg2Of with,than
R6480 T11932 T11933 arg1Of anti-CD3,and
R6481 T11933 T11931 arg2Of and,with
R6482 T11934 T11933 arg2Of anti-CD28,and
R6483 T11942 T11939 arg1Of 1,versus
R6484 T11942 T11940 arg1Of 1,211
R6485 T11942 T11941 arg1Of 1,±
R6486 T11943 T11935 arg2Of pg/ml,(
R6487 T11943 T11936 arg1Of pg/ml,588
R6488 T11943 T11937 arg1Of pg/ml,±
R6489 T11943 T11938 arg1Of pg/ml,85
R6490 T11943 T11942 arg1Of pg/ml,1
R6491 T11943 T11944 arg1Of pg/ml,;
R6492 T11945 T11944 arg2Of P,;
R6493 T11945 T11946 arg1Of P,<
R6494 T11945 T11947 arg1Of P,0.05
R6495 T11948 T11935 arg3Of ),(
R6787 T12640 T12641 arg1Of Regulation,of
R6788 T12640 T12647 arg1Of Regulation,by
R6789 T12643 T12641 arg2Of production,of
R6790 T12643 T12642 arg1Of production,IL-17
R6791 T12643 T12644 arg1Of production,in
R6792 T12646 T12644 arg2Of PBMC,in
R6793 T12646 T12645 arg1Of PBMC,RA
R6794 T12649 T12648 arg1Of cytokines,inflammatory
R6795 T12649 T12650 arg1Of cytokines,and
R6796 T12650 T12647 arg2Of and,by
R6797 T12651 T12650 arg2Of chemokines,and
R6798 T12654 T12653 arg1Of PBMC,RA
R6799 T12654 T12655 arg1Of PBMC,include
R6800 T12655 T12652 arg2Of include,Because
R6801 T12655 T12659 arg1Of include,in
R6802 T12658 T12655 arg2Of types,include
R6803 T12658 T12656 arg1Of types,several
R6804 T12658 T12657 arg1Of types,cell
R6805 T12660 T12659 arg2Of addition,in
R6806 T12660 T12661 arg1Of addition,to
R6807 T12663 T12661 arg2Of cells,to
R6808 T12663 T12662 arg1Of cells,T
R6809 T12667 T12665 arg1Of cytokines,some
R6810 T12667 T12666 arg1Of cytokines,inflammatory
R6811 T12667 T12668 arg2Of cytokines,released
R6812 T12667 T12674 arg1Of cytokines,might
R6813 T12667 T12675 arg1Of cytokines,have
R6814 T12667 T12676 arg1Of cytokines,affected
R6815 T12668 T12669 arg1Of released,from
R6816 T12670 T12671 arg1Of macrophages,and
R6817 T12671 T12669 arg2Of and,from
R6818 T12673 T12671 arg2Of lymphocytes,and
R6819 T12673 T12672 arg1Of lymphocytes,other
R6820 T12676 T12652 arg1Of affected,Because
R6821 T12676 T12664 arg1Of affected,","
R6822 T12676 T12674 arg2Of affected,might
R6823 T12676 T12675 arg2Of affected,have
R6824 T12678 T12676 arg2Of production,affected
R6825 T12678 T12677 arg1Of production,the
R6826 T12678 T12679 arg1Of production,of
R6827 T12680 T12679 arg2Of IL-17,of
R6828 T12680 T12681 arg1Of IL-17,from
R6829 T12683 T12681 arg2Of cells,from
R6830 T12683 T12682 arg1Of cells,T
R6831 T12685 T12684 arg1Of evaluate,To
R6832 T12687 T12685 arg2Of effects,evaluate
R6833 T12687 T12686 arg1Of effects,the
R6834 T12687 T12688 arg1Of effects,of
R6835 T12690 T12688 arg2Of cytokines,of
R6836 T12690 T12689 arg1Of cytokines,inflammatory
R6837 T12690 T12691 arg2Of cytokines,released
R6838 T12694 T12691 arg1Of PBMC,released
R6839 T12694 T12692 arg2Of PBMC,by
R6840 T12694 T12693 arg2Of PBMC,activated
R6841 T12696 T12685 arg1Of we,evaluate
R6842 T12696 T12697 arg1Of we,tested
R6843 T12697 T12684 modOf tested,To
R6844 T12697 T12695 arg1Of tested,","
R6845 T12699 T12697 arg2Of effects,tested
R6846 T12699 T12698 arg1Of effects,the
R6847 T12699 T12700 arg1Of effects,of
R6848 T12702 T12701 arg1Of cytokines,several
R6849 T12702 T12703 arg1Of cytokines,and
R6850 T12703 T12700 arg2Of and,of
R6851 T12703 T12705 arg1Of and,on
R6852 T12704 T12703 arg2Of chemokines,and
R6853 T12707 T12705 arg2Of production,on
R6854 T12707 T12706 arg1Of production,IL-17
R6855 T12708 T12709 arg1Of We,detected
R6856 T12709 T12715 arg1Of detected,after
R6857 T12709 T12723 arg1Of detected,","
R6858 T12709 T12724 arg1Of detected,whereas
R6859 T12711 T12709 arg2Of increase,detected
R6860 T12711 T12710 arg1Of increase,an
R6861 T12711 T12712 arg1Of increase,in
R6862 T12714 T12712 arg2Of level,in
R6863 T12714 T12713 arg1Of level,IL-17
R6864 T12716 T12715 arg2Of stimulation,after
R6865 T12716 T12717 arg1Of stimulation,with
R6866 T12718 T12717 arg2Of IL-15,with
R6867 T12718 T12719 arg1Of IL-15,(
R6868 T12721 T12719 arg2Of ng/ml,(
R6869 T12721 T12720 arg1Of ng/ml,10
R6870 T12722 T12719 arg3Of ),(
R6871 T12726 T12727 arg1Of IL-1β,(
R6872 T12726 T12731 arg1Of IL-1β,","
R6873 T12729 T12727 arg2Of ng/ml,(
R6874 T12729 T12728 arg1Of ng/ml,10
R6875 T12730 T12727 arg3Of ),(
R6876 T12731 T12737 arg1Of ",",","
R6877 T12732 T12731 arg2Of TNF-α,","
R6878 T12732 T12733 arg1Of TNF-α,(
R6879 T12735 T12733 arg2Of ng/ml,(
R6880 T12735 T12734 arg1Of ng/ml,10
R6881 T12736 T12733 arg3Of ),(
R6882 T12737 T12743 arg1Of ",",or
R6883 T12738 T12737 arg2Of IL-18,","
R6884 T12738 T12739 arg1Of IL-18,(
R6885 T12741 T12739 arg2Of ng/ml,(
R6886 T12741 T12740 arg1Of ng/ml,10
R6887 T12742 T12739 arg3Of ),(
R6888 T12743 T12725 arg2Of or,with
R6889 T12744 T12743 arg2Of TGF-β,or
R6890 T12744 T12745 arg1Of TGF-β,(
R6891 T12747 T12745 arg2Of ng/ml,(
R6892 T12747 T12746 arg1Of ng/ml,10
R6893 T12748 T12745 arg3Of ),(
R6894 T12750 T12749 arg1Of levels,the
R6895 T12750 T12751 arg1Of levels,in
R6896 T12750 T12753 arg1Of levels,were
R6897 T12750 T12754 arg1Of levels,unchanged
R6898 T12752 T12751 arg2Of IL-17,in
R6899 T12753 T12724 arg2Of were,whereas
R6900 T12753 T12725 arg1Of were,with
R6901 T12754 T12753 arg2Of unchanged,were
R6902 T12754 T12755 arg1Of unchanged,(
R6903 T12757 T12755 arg2Of 2a,(
R6904 T12757 T12756 arg1Of 2a,Fig.
R6905 T12758 T12755 arg3Of ),(
R6906 T12760 T12759 arg2Of treated,When
R6907 T12760 T12761 arg1Of treated,with
R6908 T12762 T12763 arg1Of MCP-1,(
R6909 T12762 T12767 arg1Of MCP-1,or
R6910 T12765 T12763 arg2Of ng/ml,(
R6911 T12765 T12764 arg1Of ng/ml,10
R6912 T12766 T12763 arg3Of ),(
R6913 T12767 T12761 arg2Of or,with
R6914 T12768 T12767 arg2Of IL-6,or
R6915 T12768 T12769 arg1Of IL-6,(
R6916 T12771 T12769 arg2Of ng/ml,(
R6917 T12771 T12770 arg1Of ng/ml,10
R6918 T12772 T12769 arg3Of ),(
R6919 T12775 T12774 arg1Of upregulations,significant
R6920 T12775 T12776 arg1Of upregulations,of
R6921 T12775 T12779 arg1Of upregulations,were
R6922 T12775 T12780 arg2Of upregulations,observed
R6923 T12778 T12776 arg2Of proteins,of
R6924 T12778 T12777 arg1Of proteins,IL-17
R6925 T12780 T12759 arg1Of observed,When
R6926 T12780 T12773 arg1Of observed,","
R6927 T12780 T12779 arg2Of observed,were
R6928 T12780 T12781 arg1Of observed,(
R6929 T12780 T12801 arg1Of observed,","
R6930 T12780 T12802 arg1Of observed,whereas
R6931 T12782 T12783 arg1Of 62,±
R6932 T12783 T12785 arg1Of ±,and
R6933 T12784 T12783 arg2Of 42,±
R6934 T12785 T12787 arg1Of and,±
R6935 T12786 T12785 arg2Of 50,and
R6936 T12788 T12782 arg1Of 10,62
R6937 T12788 T12784 arg1Of 10,42
R6938 T12788 T12786 arg1Of 10,50
R6939 T12792 T12789 arg1Of 11,versus
R6940 T12792 T12790 arg1Of 11,31
R6941 T12792 T12791 arg1Of 11,±
R6942 T12793 T12781 arg2Of pg/ml,(
R6943 T12793 T12788 arg1Of pg/ml,10
R6944 T12793 T12792 arg1Of pg/ml,11
R6945 T12793 T12794 arg1Of pg/ml,","
R6946 T12793 T12795 arg1Of pg/ml,respectively
R6947 T12793 T12796 arg1Of pg/ml,;
R6948 T12797 T12796 arg2Of P,;
R6949 T12797 T12798 arg1Of P,<
R6950 T12797 T12799 arg1Of P,0.05
R6951 T12800 T12781 arg3Of ),(
R6952 T12803 T12804 arg1Of none,was
R6953 T12803 T12805 arg2Of none,observed
R6954 T12805 T12802 arg2Of observed,whereas
R6955 T12805 T12804 arg2Of observed,was
R6956 T12805 T12806 arg1Of observed,with
R6957 T12807 T12808 arg1Of IL-8,(
R6958 T12807 T12812 arg1Of IL-8,","
R6959 T12810 T12808 arg2Of ng/ml,(
R6960 T12810 T12809 arg1Of ng/ml,10
R6961 T12811 T12808 arg3Of ),(
R6962 T12812 T12818 arg1Of ",",or
R6963 T12813 T12812 arg2Of MIP-1α,","
R6964 T12813 T12814 arg1Of MIP-1α,(
R6965 T12816 T12814 arg2Of ng/ml,(
R6966 T12816 T12815 arg1Of ng/ml,10
R6967 T12817 T12814 arg3Of ),(
R6968 T12818 T12806 arg2Of or,with
R6969 T12819 T12818 arg2Of MIP-1β,or
R6970 T12819 T12820 arg1Of MIP-1β,(
R6971 T12819 T12824 arg1Of MIP-1β,(
R6972 T12822 T12820 arg2Of ng/ml,(
R6973 T12822 T12821 arg1Of ng/ml,10
R6974 T12823 T12820 arg3Of ),(
R6975 T12826 T12824 arg2Of 2b,(
R6976 T12826 T12825 arg1Of 2b,Fig.
R6977 T12827 T12824 arg3Of ),(
R7308 T13598 T13599 arg1Of Inhibition,of
R7309 T13598 T13602 arg1Of Inhibition,by
R7310 T13601 T13599 arg2Of production,of
R7311 T13601 T13600 arg1Of production,IL-17
R7312 T13605 T13603 arg1Of inhibitors,signal
R7313 T13605 T13604 arg1Of inhibitors,transduction
R7314 T13605 T13606 arg1Of inhibitors,and
R7315 T13606 T13602 arg2Of and,by
R7316 T13608 T13606 arg2Of drugs,and
R7317 T13608 T13607 arg1Of drugs,anti-rheumatic
R7318 T13610 T13609 arg2Of observed,Having
R7319 T13614 T13610 arg2Of production,observed
R7320 T13614 T13611 arg1Of production,the
R7321 T13614 T13612 arg2Of production,increased
R7322 T13614 T13613 arg1Of production,IL-17
R7323 T13614 T13615 arg1Of production,in
R7324 T13617 T13615 arg2Of PBMC,in
R7325 T13617 T13616 arg1Of PBMC,RA
R7326 T13620 T13609 modOf was,Having
R7327 T13620 T13618 arg1Of was,","
R7328 T13621 T13620 arg2Of important,was
R7329 T13623 T13609 arg1Of know,Having
R7330 T13623 T13610 arg1Of know,observed
R7331 T13623 T13619 arg1Of know,it
R7332 T13623 T13620 arg1Of know,was
R7333 T13623 T13621 arg1Of know,important
R7334 T13623 T13622 arg1Of know,to
R7335 T13624 T13623 arg2Of which,know
R7336 T13627 T13624 arg1Of pathways,which
R7337 T13627 T13625 arg1Of pathways,signal
R7338 T13627 T13626 arg1Of pathways,transduction
R7339 T13627 T13628 arg1Of pathways,were
R7340 T13627 T13629 arg2Of pathways,involved
R7341 T13629 T13628 arg2Of involved,were
R7342 T13631 T13630 arg2Of illustrated,As
R7343 T13631 T13632 arg1Of illustrated,in
R7344 T13633 T13632 arg2Of Fig.,in
R7345 T13633 T13634 arg1Of Fig.,3
R7346 T13638 T13636 arg1Of decrease,an
R7347 T13638 T13637 arg1Of decrease,significant
R7348 T13638 T13639 arg1Of decrease,in
R7349 T13638 T13643 arg1Of decrease,was
R7350 T13638 T13644 arg2Of decrease,observed
R7351 T13642 T13639 arg2Of production,in
R7352 T13642 T13640 arg1Of production,anti-CD3-induced
R7353 T13642 T13641 arg1Of production,IL-17
R7354 T13644 T13630 arg1Of observed,As
R7355 T13644 T13635 arg1Of observed,","
R7356 T13644 T13643 arg2Of observed,was
R7357 T13644 T13645 arg1Of observed,when
R7358 T13644 T13659 arg1Of observed,(
R7359 T13646 T13645 arg2Of co-incubated,when
R7360 T13646 T13647 arg1Of co-incubated,with
R7361 T13646 T13654 arg1Of co-incubated,in
R7362 T13649 T13648 arg1Of inhibitor,NF-κB
R7363 T13649 T13650 arg1Of inhibitor,","
R7364 T13650 T13652 arg1Of ",",and
R7365 T13651 T13650 arg2Of PDTC,","
R7366 T13652 T13647 arg2Of and,with
R7367 T13653 T13652 arg2Of dexamethasone,and
R7368 T13654 T13656 arg1Of in,with
R7369 T13655 T13654 arg2Of comparison,in
R7370 T13657 T13654 arg3Of anti-CD3,in
R7371 T13657 T13658 arg1Of anti-CD3,alone
R7372 T13660 T13661 arg1Of 38,±
R7373 T13661 T13663 arg1Of ±,and
R7374 T13662 T13661 arg2Of 5,±
R7375 T13664 T13665 arg1Of 54,±
R7376 T13665 T13663 arg2Of ±,and
R7377 T13666 T13665 arg2Of 11,±
R7378 T13670 T13660 arg1Of 19,38
R7379 T13670 T13662 arg1Of 19,5
R7380 T13670 T13664 arg1Of 19,54
R7381 T13670 T13666 arg1Of 19,11
R7382 T13670 T13667 arg1Of 19,versus
R7383 T13670 T13668 arg1Of 19,98
R7384 T13670 T13669 arg1Of 19,±
R7385 T13671 T13659 arg2Of pg/ml,(
R7386 T13671 T13670 arg1Of pg/ml,19
R7387 T13671 T13672 arg1Of pg/ml,","
R7388 T13671 T13673 arg1Of pg/ml,respectively
R7389 T13671 T13674 arg1Of pg/ml,;
R7390 T13675 T13674 arg2Of P,;
R7391 T13675 T13676 arg1Of P,<
R7392 T13675 T13677 arg1Of P,0.05
R7393 T13678 T13659 arg3Of ),(
R7394 T13679 T13680 arg1Of LY294002,and
R7395 T13680 T13691 arg1Of and,inhibited
R7396 T13681 T13680 arg2Of wortmannin,and
R7397 T13685 T13683 arg2Of inhibitor,as
R7398 T13685 T13684 arg1Of inhibitor,an
R7399 T13685 T13686 arg1Of inhibitor,of
R7400 T13687 T13686 arg2Of PI3K,of
R7401 T13691 T13682 arg1Of inhibited,","
R7402 T13691 T13683 arg1Of inhibited,as
R7403 T13691 T13688 arg1Of inhibited,","
R7404 T13691 T13689 arg1Of inhibited,also
R7405 T13691 T13690 arg1Of inhibited,markedly
R7406 T13695 T13691 arg2Of production,inhibited
R7407 T13695 T13692 arg1Of production,the
R7408 T13695 T13693 arg1Of production,anti-CD3-induced
R7409 T13695 T13694 arg1Of production,IL-17
R7410 T13695 T13696 arg1Of production,in
R7411 T13695 T13699 arg1Of production,(
R7412 T13698 T13696 arg2Of PBMC,in
R7413 T13698 T13697 arg1Of PBMC,RA
R7414 T13706 T13700 arg1Of 10,98
R7415 T13706 T13701 arg1Of 10,±
R7416 T13706 T13702 arg1Of 10,19
R7417 T13706 T13703 arg1Of 10,versus
R7418 T13706 T13704 arg1Of 10,38
R7419 T13706 T13705 arg1Of 10,±
R7420 T13707 T13708 arg1Of pg/ml,[
R7421 T13707 T13713 arg1Of pg/ml,and
R7422 T13709 T13708 arg2Of P,[
R7423 T13709 T13710 arg1Of P,<
R7424 T13709 T13711 arg1Of P,0.005
R7425 T13712 T13708 arg3Of ],[
R7426 T13713 T13699 arg2Of and,(
R7427 T13713 T13706 arg1Of and,10
R7428 T13713 T13723 arg1Of and,","
R7429 T13713 T13724 arg1Of and,respectively
R7430 T13714 T13715 arg1Of 48,±
R7431 T13716 T13715 arg2Of 4,±
R7432 T13717 T13713 arg2Of pg/ml,and
R7433 T13717 T13714 arg1Of pg/ml,48
R7434 T13717 T13716 arg1Of pg/ml,4
R7435 T13717 T13718 arg1Of pg/ml,[
R7436 T13719 T13718 arg2Of P,[
R7437 T13719 T13720 arg1Of P,<
R7438 T13719 T13721 arg1Of P,0.05
R7439 T13722 T13718 arg3Of ],[
R7440 T13725 T13699 arg3Of ),(
R7441 T13728 T13726 arg1Of inhibitors,The
R7442 T13728 T13727 arg1Of inhibitors,calcineurin
R7443 T13730 T13729 arg1Of A,cyclosporin
R7444 T13730 T13731 arg1Of A,and
R7445 T13731 T13728 arg1Of and,inhibitors
R7446 T13731 T13734 arg1Of and,downregulated
R7447 T13732 T13731 arg2Of FK506,and
R7448 T13734 T13733 arg1Of downregulated,also
R7449 T13734 T13739 arg1Of downregulated,well
R7450 T13734 T13752 arg1Of downregulated,","
R7451 T13734 T13753 arg1Of downregulated,whereas
R7452 T13737 T13734 arg2Of secretion,downregulated
R7453 T13737 T13735 arg1Of secretion,the
R7454 T13737 T13736 arg1Of secretion,IL-17
R7455 T13739 T13738 arg1Of well,as
R7456 T13740 T13739 arg2Of as,well
R7457 T13744 T13742 arg1Of kinase,mitogen-activated
R7458 T13744 T13743 arg1Of kinase,protein
R7459 T13744 T13745 arg1Of kinase,(
R7460 T13746 T13745 arg2Of MAPK,(
R7461 T13747 T13745 arg3Of ),(
R7462 T13750 T13741 arg1Of SB203580,the
R7463 T13750 T13744 arg1Of SB203580,kinase
R7464 T13750 T13748 arg1Of SB203580,p38
R7465 T13750 T13749 arg1Of SB203580,inhibitor
R7466 T13750 T13751 arg1Of SB203580,did
R7467 T13751 T13740 arg2Of did,as
R7468 T13754 T13755 arg1Of rapamycin,and
R7469 T13755 T13757 arg1Of and,had
R7470 T13756 T13755 arg2Of PD98059,and
R7471 T13757 T13753 arg2Of had,whereas
R7472 T13757 T13760 arg1Of had,on
R7473 T13759 T13757 arg2Of effect,had
R7474 T13759 T13758 arg1Of effect,no
R7475 T13762 T13760 arg2Of levels,on
R7476 T13762 T13761 arg1Of levels,IL-17
R7477 T13762 T13763 arg1Of levels,(
R7478 T13764 T13763 arg2Of Fig.,(
R7479 T13764 T13765 arg1Of Fig.,3
R7480 T13766 T13763 arg3Of ),(
R7481 T13768 T13767 arg1Of evaluate,To
R7482 T13768 T13777 arg1Of evaluate,at
R7483 T13770 T13768 arg2Of possibility,evaluate
R7484 T13770 T13769 arg1Of possibility,the
R7485 T13770 T13771 arg1Of possibility,of
R7486 T13770 T13774 arg1Of possibility,by
R7487 T13773 T13771 arg2Of inhibition,of
R7488 T13773 T13772 arg1Of inhibition,non-specific
R7489 T13776 T13774 arg2Of drug,by
R7490 T13776 T13775 arg1Of drug,the
R7491 T13779 T13777 arg2Of concentrations,at
R7492 T13779 T13778 arg1Of concentrations,high
R7493 T13781 T13768 arg1Of we,evaluate
R7494 T13781 T13782 arg1Of we,observed
R7495 T13782 T13767 modOf observed,To
R7496 T13782 T13780 arg1Of observed,","
R7497 T13785 T13782 arg2Of response,observed
R7498 T13785 T13783 arg1Of response,the
R7499 T13785 T13784 arg1Of response,dose
R7500 T13785 T13786 arg1Of response,of
R7501 T13785 T13790 arg1Of response,for
R7502 T13787 T13788 arg1Of PDTC,and
R7503 T13788 T13786 arg2Of and,of
R7504 T13789 T13788 arg2Of LY294002,and
R7505 T13792 T13790 arg2Of inhibition,for
R7506 T13792 T13791 arg1Of inhibition,the
R7507 T13792 T13793 arg1Of inhibition,of
R7508 T13795 T13793 arg2Of production,of
R7509 T13795 T13794 arg1Of production,IL-17
R7510 T13795 T13796 arg1Of production,in
R7511 T13797 T13796 arg2Of PBMC,in
R7512 T13798 T13799 arg1Of There,were
R7513 T13801 T13799 arg2Of inhibitions,were
R7514 T13801 T13800 arg1Of inhibitions,dose-dependent
R7515 T13801 T13802 arg1Of inhibitions,of
R7516 T13804 T13802 arg2Of production,of
R7517 T13804 T13803 arg1Of production,IL-17
R7518 T13804 T13805 arg1Of production,with
R7519 T13807 T13805 arg2Of inhibitors,with
R7520 T13807 T13806 arg1Of inhibitors,chemical
R7521 T13807 T13808 arg1Of inhibitors,(
R7522 T13810 T13808 arg2Of 4a,(
R7523 T13810 T13809 arg1Of 4a,Fig.
R7524 T13811 T13808 arg3Of ),(
R7525 T13814 T13812 arg1Of inhibitors,The
R7526 T13814 T13813 arg1Of inhibitors,other
R7527 T13814 T13815 arg1Of inhibitors,in
R7528 T13814 T13821 arg1Of inhibitors,showed
R7529 T13816 T13815 arg2Of addition,in
R7530 T13816 T13817 arg1Of addition,to
R7531 T13818 T13819 arg1Of PDTC,and
R7532 T13819 T13817 arg2Of and,to
R7533 T13820 T13819 arg2Of LY294002,and
R7534 T13824 T13821 arg2Of pattern,showed
R7535 T13824 T13822 arg1Of pattern,the
R7536 T13824 T13823 arg1Of pattern,same
R7537 T13824 T13825 arg1Of pattern,of
R7538 T13826 T13825 arg2Of inhibition,of
R7539 T13828 T13827 arg1Of effects,Cytotoxic
R7540 T13828 T13829 arg1Of effects,on
R7541 T13828 T13838 arg1Of effects,were
R7542 T13828 T13840 arg2Of effects,observed
R7543 T13830 T13829 arg2Of PBMC,on
R7544 T13830 T13831 arg1Of PBMC,by
R7545 T13830 T13835 arg1Of PBMC,at
R7546 T13834 T13831 arg2Of inhibitors,by
R7547 T13834 T13832 arg1Of inhibitors,the
R7548 T13834 T13833 arg1Of inhibitors,chemical
R7549 T13837 T13835 arg2Of concentrations,at
R7550 T13837 T13836 arg1Of concentrations,experimental
R7551 T13840 T13838 arg2Of observed,were
R7552 T13840 T13839 arg1Of observed,not
R7553 T13840 T13841 arg1Of observed,(
R7554 T13843 T13841 arg2Of 4b,(
R7555 T13843 T13842 arg1Of 4b,Fig.
R7556 T13844 T13841 arg3Of ),(
R7980 T14508 T14506 arg1Of expression,IL-17
R7981 T14508 T14507 arg1Of expression,mRNA
R7982 T14508 T14509 arg1Of expression,in
R7983 T14511 T14509 arg2Of PBMC,in
R7984 T14511 T14510 arg1Of PBMC,RA
R7985 T14513 T14512 arg1Of see,To
R7986 T14517 T14515 arg2Of production,enhanced
R7987 T14517 T14516 arg1Of production,IL-17
R7988 T14517 T14518 arg1Of production,could
R7989 T14517 T14519 arg1Of production,be
R7990 T14517 T14520 arg2Of production,regulated
R7991 T14520 T14513 arg2Of regulated,see
R7992 T14520 T14514 arg1Of regulated,whether
R7993 T14520 T14518 arg2Of regulated,could
R7994 T14520 T14519 arg2Of regulated,be
R7995 T14520 T14521 arg1Of regulated,at
R7996 T14524 T14521 arg2Of level,at
R7997 T14524 T14522 arg1Of level,a
R7998 T14524 T14523 arg1Of level,transcriptional
R7999 T14530 T14526 arg1Of reaction,semi-quantatitive
R8000 T14530 T14527 arg1Of reaction,reverse
R8001 T14530 T14528 arg1Of reaction,transcription–polymerase
R8002 T14530 T14529 arg1Of reaction,chain
R8003 T14530 T14531 arg1Of reaction,was
R8004 T14530 T14532 arg2Of reaction,performed
R8005 T14532 T14512 modOf performed,To
R8006 T14532 T14525 arg1Of performed,","
R8007 T14532 T14531 arg2Of performed,was
R8008 T14533 T14534 arg1Of We,observed
R8009 T14534 T14542 arg1Of observed,after
R8010 T14534 T14546 arg1Of observed,;
R8011 T14537 T14534 arg2Of increase,observed
R8012 T14537 T14535 arg1Of increase,a
R8013 T14537 T14536 arg1Of increase,dose-dependent
R8014 T14537 T14538 arg1Of increase,in
R8015 T14541 T14538 arg2Of transcripts,in
R8016 T14541 T14539 arg1Of transcripts,IL-17
R8017 T14541 T14540 arg1Of transcripts,mRNA
R8018 T14543 T14542 arg2Of stimulation,after
R8019 T14543 T14544 arg1Of stimulation,with
R8020 T14545 T14544 arg2Of anti-CD3,with
R8021 T14547 T14548 arg1Of this,was
R8022 T14547 T14549 arg2Of this,inhibited
R8023 T14549 T14546 arg2Of inhibited,;
R8024 T14549 T14548 arg2Of inhibited,was
R8025 T14549 T14550 arg1Of inhibited,by
R8026 T14549 T14556 arg1Of inhibited,by
R8027 T14549 T14561 arg1Of inhibited,(
R8028 T14550 T14555 arg1Of by,and
R8029 T14554 T14550 arg2Of LY294002,by
R8030 T14554 T14551 arg1Of LY294002,the
R8031 T14554 T14552 arg1Of LY294002,PI3K
R8032 T14554 T14553 arg1Of LY294002,inhibitor
R8033 T14556 T14555 arg2Of by,and
R8034 T14560 T14556 arg2Of PDTC,by
R8035 T14560 T14557 arg1Of PDTC,the
R8036 T14560 T14558 arg1Of PDTC,NF-κB
R8037 T14560 T14559 arg1Of PDTC,inhibitor
R8038 T14562 T14561 arg2Of Fig.,(
R8039 T14562 T14563 arg1Of Fig.,5
R8040 T14564 T14561 arg3Of ),(
R8171 T14971 T14972 arg1Of Activation,of
R8172 T14971 T14977 arg1Of Activation,on
R8173 T14971 T14980 arg1Of Activation,by
R8174 T14976 T14972 arg2Of pathway,of
R8175 T14976 T14973 arg1Of pathway,PI3K/Akt
R8176 T14976 T14974 arg1Of pathway,signal
R8177 T14976 T14975 arg1Of pathway,transduction
R8178 T14979 T14977 arg2Of production,on
R8179 T14979 T14978 arg1Of production,IL-17
R8180 T14981 T14980 arg2Of anti-CD3,by
R8181 T14983 T14982 arg1Of determine,To
R8182 T14986 T14983 arg2Of molecules,determine
R8183 T14986 T14984 arg1Of molecules,downstream
R8184 T14986 T14985 arg1Of molecules,effector
R8185 T14986 T14987 arg1Of molecules,of
R8186 T14990 T14987 arg2Of pathway,of
R8187 T14990 T14988 arg1Of pathway,the
R8188 T14990 T14989 arg1Of pathway,PI3K
R8189 T14992 T14983 arg1Of we,determine
R8190 T14992 T14993 arg1Of we,evaluated
R8191 T14993 T14982 modOf evaluated,To
R8192 T14993 T14991 arg1Of evaluated,","
R8193 T14995 T14993 arg2Of activation,evaluated
R8194 T14995 T14994 arg1Of activation,the
R8195 T14995 T14996 arg1Of activation,of
R8196 T14995 T14998 arg1Of activation,by
R8197 T14997 T14996 arg2Of Akt,of
R8198 T15000 T14998 arg2Of blotting,by
R8199 T15000 T14999 arg1Of blotting,western
R8200 T15002 T15001 arg2Of shown,As
R8201 T15002 T15003 arg1Of shown,in
R8202 T15002 T15006 arg1Of shown,","
R8203 T15002 T15007 arg1Of shown,at
R8204 T15004 T15003 arg2Of Fig.,in
R8205 T15004 T15005 arg1Of Fig.,6
R8206 T15009 T15007 arg2Of min,at
R8207 T15009 T15008 arg1Of min,10
R8208 T15009 T15010 arg1Of min,of
R8209 T15009 T15012 arg1Of min,with
R8210 T15011 T15010 arg2Of incubation,of
R8211 T15013 T15014 arg1Of anti-CD3,(
R8212 T15013 T15018 arg1Of anti-CD3,or
R8213 T15016 T15014 arg2Of μg/ml,(
R8214 T15016 T15015 arg1Of μg/ml,10
R8215 T15017 T15014 arg3Of ),(
R8216 T15018 T15012 arg2Of or,with
R8217 T15019 T15018 arg2Of LY294002,or
R8218 T15019 T15020 arg1Of LY294002,(
R8219 T15022 T15020 arg2Of μM,(
R8220 T15022 T15021 arg1Of μM,20
R8221 T15023 T15020 arg3Of ),(
R8222 T15026 T15025 arg1Of difference,no
R8223 T15026 T15027 arg1Of difference,in
R8224 T15026 T15033 arg1Of difference,was
R8225 T15026 T15034 arg2Of difference,observed
R8226 T15029 T15027 arg2Of amounts,in
R8227 T15029 T15028 arg1Of amounts,the
R8228 T15029 T15030 arg1Of amounts,of
R8229 T15032 T15030 arg2Of Akt,of
R8230 T15032 T15031 arg2Of Akt,phosphorylated
R8231 T15034 T15001 arg1Of observed,As
R8232 T15034 T15024 arg1Of observed,","
R8233 T15034 T15033 arg2Of observed,was
R8234 T15039 T15037 arg2Of min,after
R8235 T15039 T15038 arg1Of min,30
R8236 T15039 T15040 arg1Of min,of
R8237 T15041 T15040 arg2Of incubation,of
R8238 T15044 T15043 arg2Of Akt,phosphorylated
R8239 T15044 T15045 arg1Of Akt,increased
R8240 T15045 T15046 arg1Of increased,(
R8241 T15045 T15051 arg1Of increased,and
R8242 T15047 T15046 arg2Of lane,(
R8243 T15047 T15048 arg1Of lane,2
R8244 T15049 T15046 arg3Of ),(
R8245 T15051 T15035 arg1Of and,However
R8246 T15051 T15036 arg1Of and,","
R8247 T15051 T15037 arg1Of and,after
R8248 T15051 T15042 arg1Of and,","
R8249 T15051 T15050 arg1Of and,","
R8250 T15053 T15052 arg1Of effect,the
R8251 T15053 T15054 arg1Of effect,of
R8252 T15053 T15056 arg1Of effect,by
R8253 T15053 T15062 arg1Of effect,reached
R8254 T15053 T15069 arg1Of effect,lasting
R8255 T15055 T15054 arg2Of inhibition,of
R8256 T15057 T15056 arg2Of LY294002,by
R8257 T15057 T15058 arg1Of LY294002,(
R8258 T15059 T15058 arg2Of lane,(
R8259 T15059 T15060 arg1Of lane,3
R8260 T15061 T15058 arg3Of ),(
R8261 T15062 T15051 arg2Of reached,and
R8262 T15062 T15065 arg1Of reached,at
R8263 T15062 T15068 arg1Of reached,","
R8264 T15062 T15069 modOf reached,lasting
R8265 T15064 T15062 arg2Of peak,reached
R8266 T15064 T15063 arg1Of peak,a
R8267 T15067 T15065 arg2Of min,at
R8268 T15067 T15066 arg1Of min,60
R8269 T15069 T15070 arg1Of lasting,to
R8270 T15072 T15070 arg2Of min,to
R8271 T15072 T15071 arg1Of min,120–240
R8272 T15074 T15073 arg2Of contrast,In
R8273 T15077 T15078 arg1Of Akt,and
R8274 T15078 T15076 arg1Of and,non-phosphorylated
R8275 T15078 T15080 arg1Of and,remained
R8276 T15078 T15081 arg1Of and,unchanged
R8277 T15079 T15078 arg2Of β-actin,and
R8278 T15080 T15073 arg1Of remained,In
R8279 T15080 T15075 arg1Of remained,","
R8280 T15080 T15082 arg1Of remained,regardless
R8281 T15081 T15080 arg2Of unchanged,remained
R8282 T15082 T15083 arg1Of regardless,of
R8283 T15085 T15083 arg2Of time,of
R8284 T15085 T15084 arg1Of time,incubation
R8285 T15086 T15087 arg1Of PHA,","
R8286 T15087 T15090 arg1Of ",",and
R8287 T15089 T15087 arg2Of A,","
R8288 T15089 T15088 arg1Of A,concanavalin
R8289 T15090 T15093 arg1Of and,demonstrated
R8290 T15091 T15090 arg2Of IL-15,and
R8291 T15093 T15092 arg1Of demonstrated,also
R8292 T15093 T15097 arg1Of demonstrated,on
R8293 T15093 T15100 arg1Of demonstrated,as
R8294 T15093 T15104 arg1Of demonstrated,","
R8295 T15093 T15105 arg1Of demonstrated,which
R8296 T15093 T15106 arg1Of demonstrated,was
R8297 T15096 T15093 arg2Of effect,demonstrated
R8298 T15096 T15094 arg1Of effect,the
R8299 T15096 T15095 arg1Of effect,same
R8300 T15099 T15097 arg2Of Akt,on
R8301 T15099 T15098 arg2Of Akt,phosphorylated
R8302 T15101 T15100 arg2Of shown,as
R8303 T15101 T15102 arg1Of shown,with
R8304 T15103 T15102 arg2Of anti-CD3,with
R8305 T15106 T15109 arg1Of was,by
R8306 T15106 T15116 arg1Of was,by
R8307 T15108 T15106 arg2Of inhibition,was
R8308 T15108 T15107 arg1Of inhibition,an
R8309 T15109 T15115 arg1Of by,as
R8310 T15110 T15111 arg1Of wortmannin,and
R8311 T15111 T15109 arg2Of and,by
R8312 T15112 T15111 arg2Of PDTC,and
R8313 T15115 T15113 arg1Of as,as
R8314 T15115 T15114 arg1Of as,well
R8315 T15116 T15115 arg2Of by,as
R8316 T15117 T15116 arg2Of LY294002,by
R8317 T15117 T15118 arg1Of LY294002,(
R8318 T15119 T15118 arg2Of data,(
R8319 T15119 T15121 arg2Of data,shown
R8320 T15121 T15120 arg1Of shown,not
R8321 T15122 T15118 arg3Of ),(
R8583 T15893 T15894 arg1Of Activation,of
R8584 T15893 T15904 arg1Of Activation,in
R8585 T15896 T15897 arg1Of NF-κB,and
R8586 T15899 T15897 arg2Of protein-1,and
R8587 T15899 T15898 arg1Of protein-1,activator
R8588 T15899 T15900 arg1Of protein-1,(
R8589 T15901 T15900 arg2Of AP-1,(
R8590 T15902 T15900 arg3Of ),(
R8591 T15903 T15894 arg2Of pathway,of
R8592 T15903 T15895 arg1Of pathway,the
R8593 T15903 T15896 arg1Of pathway,NF-κB
R8594 T15903 T15899 arg1Of pathway,protein-1
R8595 T15908 T15904 arg2Of region,in
R8596 T15908 T15905 arg1Of region,the
R8597 T15908 T15906 arg1Of region,IL-17
R8598 T15908 T15907 arg1Of region,promoter
R8599 T15910 T15909 arg1Of investigate,To
R8600 T15910 T15911 arg1Of investigate,further
R8601 T15915 T15910 arg2Of pathway,investigate
R8602 T15915 T15912 arg1Of pathway,the
R8603 T15915 T15913 arg1Of pathway,intracellular
R8604 T15915 T15914 arg1Of pathway,signaling
R8605 T15915 T15916 arg2Of pathway,activated
R8606 T15915 T15930 arg1Of pathway,responsible
R8607 T15916 T15929 arg1Of activated,and
R8608 T15918 T15919 arg1Of anti-CD3,plus
R8609 T15919 T15921 arg1Of plus,","
R8610 T15920 T15919 arg2Of anti-CD28,plus
R8611 T15921 T15924 arg1Of ",",","
R8612 T15923 T15921 arg2Of A,","
R8613 T15923 T15922 arg1Of A,concanavalin
R8614 T15924 T15926 arg1Of ",",and
R8615 T15925 T15924 arg2Of PHA,","
R8616 T15926 T15916 arg1Of and,activated
R8617 T15926 T15917 arg2Of and,by
R8618 T15927 T15926 arg2Of IL-15,and
R8619 T15929 T15928 arg1Of and,","
R8620 T15930 T15929 arg2Of responsible,and
R8621 T15930 T15931 arg1Of responsible,for
R8622 T15932 T15931 arg2Of inducing,for
R8623 T15934 T15932 arg2Of expression,inducing
R8624 T15934 T15933 arg1Of expression,IL-17
R8625 T15936 T15937 arg1Of we,performed
R8626 T15937 T15909 modOf performed,To
R8627 T15937 T15935 arg1Of performed,","
R8628 T15941 T15937 arg2Of assay,performed
R8629 T15941 T15938 arg1Of assay,an
R8630 T15941 T15939 arg1Of assay,electrophoretic
R8631 T15941 T15940 arg1Of assay,mobility-shift
R8632 T15941 T15942 arg1Of assay,(
R8633 T15941 T15945 arg1Of assay,of
R8634 T15943 T15942 arg2Of EMSA,(
R8635 T15944 T15942 arg3Of ),(
R8636 T15948 T15945 arg2Of sites,of
R8637 T15948 T15946 arg1Of sites,NF-κB
R8638 T15948 T15947 arg1Of sites,recognition
R8639 T15948 T15949 arg1Of sites,in
R8640 T15951 T15949 arg2Of promoters,in
R8641 T15951 T15950 arg1Of promoters,the
R8642 T15951 T15952 arg1Of promoters,of
R8643 T15953 T15952 arg2Of IL-17,of
R8644 T15955 T15954 arg2Of shown,As
R8645 T15955 T15956 arg1Of shown,in
R8646 T15958 T15956 arg2Of 7a,in
R8647 T15958 T15957 arg1Of 7a,Fig.
R8648 T15961 T15960 arg1Of extracts,nuclear
R8649 T15961 T15962 arg1Of extracts,from
R8650 T15961 T15974 arg1Of extracts,demonstrated
R8651 T15964 T15962 arg2Of PBMC,from
R8652 T15964 T15963 arg1Of PBMC,RA
R8653 T15964 T15965 arg2Of PBMC,stimulated
R8654 T15965 T15966 arg1Of stimulated,with
R8655 T15967 T15968 arg1Of anti-CD3,plus
R8656 T15968 T15966 arg2Of plus,with
R8657 T15968 T15970 arg1Of plus,(
R8658 T15969 T15968 arg2Of anti-CD28,plus
R8659 T15971 T15970 arg2Of lane,(
R8660 T15971 T15972 arg1Of lane,2
R8661 T15973 T15970 arg3Of ),(
R8662 T15974 T15954 arg1Of demonstrated,As
R8663 T15974 T15959 arg1Of demonstrated,","
R8664 T15974 T15982 arg1Of demonstrated,in
R8665 T15976 T15974 arg2Of binding,demonstrated
R8666 T15976 T15975 arg2Of binding,increased
R8667 T15976 T15977 arg1Of binding,of
R8668 T15976 T15979 arg1Of binding,to
R8669 T15978 T15977 arg2Of NF-κB,of
R8670 T15981 T15979 arg2Of promoters,to
R8671 T15981 T15980 arg1Of promoters,IL-17
R8672 T15983 T15982 arg2Of comparison,in
R8673 T15983 T15984 arg1Of comparison,with
R8674 T15985 T15984 arg2Of that,with
R8675 T15985 T15986 arg1Of that,of
R8676 T15987 T15986 arg2Of controls,of
R8677 T15987 T15988 arg1Of controls,(
R8678 T15989 T15988 arg2Of lane,(
R8679 T15989 T15990 arg1Of lane,1
R8680 T15991 T15988 arg3Of ),(
R8681 T15994 T15992 arg1Of assay,A
R8682 T15994 T15993 arg1Of assay,supershift
R8683 T15994 T15995 arg1Of assay,demonstrated
R8684 T15995 T16009 arg1Of demonstrated,in
R8685 T15997 T15995 arg2Of bands,demonstrated
R8686 T15997 T15996 arg2Of bands,shifted
R8687 T15997 T15998 arg1Of bands,in
R8688 T15999 T16000 arg1Of p65,and
R8689 T16000 T15998 arg2Of and,in
R8690 T16000 T16002 arg1Of and,(
R8691 T16001 T16000 arg2Of p50,and
R8692 T16004 T16005 arg1Of 3,and
R8693 T16005 T16002 arg2Of and,(
R8694 T16005 T16003 arg1Of and,lanes
R8695 T16006 T16005 arg2Of 4,and
R8696 T16007 T16002 arg3Of ),(
R8697 T16009 T16008 arg1Of in,not
R8698 T16010 T16009 arg2Of c-Rel,in
R8699 T16010 T16011 arg1Of c-Rel,(
R8700 T16012 T16011 arg2Of lane,(
R8701 T16012 T16013 arg1Of lane,5
R8702 T16014 T16011 arg3Of ),(
R8703 T16017 T16015 arg2Of PBMC,In
R8704 T16017 T16016 arg1Of PBMC,normal
R8705 T16020 T16018 arg1Of pattern,the
R8706 T16020 T16019 arg1Of pattern,same
R8707 T16020 T16021 arg1Of pattern,was
R8708 T16020 T16022 arg2Of pattern,observed
R8709 T16022 T16015 arg1Of observed,In
R8710 T16022 T16021 arg2Of observed,was
R8711 T16022 T16024 arg1Of observed,but
R8712 T16024 T16023 arg1Of but,","
R8713 T16026 T16025 arg1Of degree,the
R8714 T16026 T16027 arg1Of degree,of
R8715 T16026 T16030 arg1Of degree,by
R8716 T16026 T16034 arg1Of degree,was
R8717 T16026 T16036 arg1Of degree,intense
R8718 T16029 T16027 arg2Of activation,of
R8719 T16029 T16028 arg1Of activation,NF-κB
R8720 T16031 T16032 arg1Of anti-CD3,plus
R8721 T16032 T16030 arg2Of plus,by
R8722 T16033 T16032 arg2Of anti-CD28,plus
R8723 T16034 T16024 arg2Of was,but
R8724 T16036 T16034 arg2Of intense,was
R8725 T16036 T16035 arg1Of intense,less
R8726 T16036 T16037 arg1Of intense,than
R8727 T16038 T16037 arg2Of that,than
R8728 T16038 T16039 arg1Of that,in
R8729 T16041 T16039 arg2Of PBMC,in
R8730 T16041 T16040 arg1Of PBMC,RA
R8731 T16041 T16042 arg1Of PBMC,(
R8732 T16044 T16042 arg2Of 7b,(
R8733 T16044 T16043 arg1Of 7b,Fig.
R8734 T16045 T16042 arg3Of ),(
R8735 T16047 T16046 arg1Of confirm,To
R8736 T16049 T16047 arg2Of link,confirm
R8737 T16049 T16048 arg1Of link,the
R8738 T16049 T16050 arg1Of link,between
R8739 T16052 T16051 arg1Of activity,PI3K
R8740 T16052 T16053 arg1Of activity,and
R8741 T16053 T16050 arg2Of and,between
R8742 T16054 T16053 arg2Of NF-κB,and
R8743 T16056 T16047 arg1Of we,confirm
R8744 T16056 T16057 arg1Of we,performed
R8745 T16057 T16046 modOf performed,To
R8746 T16057 T16055 arg1Of performed,","
R8747 T16058 T16057 arg2Of EMSA,performed
R8748 T16058 T16059 modOf EMSA,to
R8749 T16060 T16059 arg1Of determine,to
R8750 T16060 T16065 arg1Of determine,after
R8751 T16064 T16060 arg2Of activity,determine
R8752 T16064 T16061 arg1Of activity,the
R8753 T16064 T16062 arg1Of activity,NF-κB
R8754 T16064 T16063 arg1Of activity,binding
R8755 T16066 T16065 arg2Of treatment,after
R8756 T16066 T16067 arg1Of treatment,with
R8757 T16069 T16070 arg1Of LY294002,and
R8758 T16070 T16067 arg2Of and,with
R8759 T16070 T16068 arg1Of and,both
R8760 T16071 T16070 arg2Of PDTC,and
R8761 T16073 T16072 arg1Of agents,Both
R8762 T16073 T16074 arg1Of agents,block
R8763 T16077 T16074 arg2Of activity,block
R8764 T16077 T16075 arg1Of activity,NF-κB
R8765 T16077 T16076 arg1Of activity,DNA-binding
R8766 T16077 T16078 arg1Of activity,in
R8767 T16081 T16078 arg2Of promoter,in
R8768 T16081 T16079 arg1Of promoter,the
R8769 T16081 T16080 arg1Of promoter,IL-17
R8770 T16081 T16082 arg1Of promoter,(
R8771 T16084 T16082 arg2Of 7c,(
R8772 T16084 T16083 arg1Of 7c,Fig.
R8773 T16085 T16082 arg3Of ),(
R8774 T16087 T16086 arg1Of blotting,Western
R8775 T16087 T16088 arg1Of blotting,for
R8776 T16087 T16090 arg1Of blotting,showed
R8777 T16089 T16088 arg2Of IκB-α,for
R8778 T16091 T16090 arg2Of inhibition,showed
R8779 T16091 T16092 arg1Of inhibition,of
R8780 T16093 T16092 arg2Of degradation,of
R8781 T16093 T16094 arg1Of degradation,of
R8782 T16093 T16096 arg1Of degradation,by
R8783 T16093 T16100 arg1Of degradation,at
R8784 T16095 T16094 arg2Of IκB-α,of
R8785 T16097 T16098 arg1Of LY294002,and
R8786 T16098 T16096 arg2Of and,by
R8787 T16099 T16098 arg2Of PDTC,and
R8788 T16103 T16100 arg2Of time,at
R8789 T16103 T16101 arg1Of time,the
R8790 T16103 T16102 arg1Of time,same
R8791 T16103 T16104 arg1Of time,(
R8792 T16106 T16104 arg2Of 7c,(
R8793 T16106 T16105 arg1Of 7c,Fig.
R8794 T16107 T16104 arg3Of ),(
R8795 T16109 T16108 arg2Of contrast,In
R8796 T16113 T16111 arg1Of pathway,the
R8797 T16113 T16112 arg1Of pathway,AP-1
R8798 T16113 T16114 arg1Of pathway,was
R8799 T16113 T16116 arg2Of pathway,activated
R8800 T16116 T16108 arg1Of activated,In
R8801 T16116 T16110 arg1Of activated,","
R8802 T16116 T16114 arg2Of activated,was
R8803 T16116 T16115 arg1Of activated,not
R8804 T16116 T16128 arg1Of activated,","
R8805 T16116 T16129 modOf activated,demonstrating
R8806 T16118 T16116 arg1Of stimulation,activated
R8807 T16118 T16117 arg2Of stimulation,by
R8808 T16118 T16119 arg1Of stimulation,with
R8809 T16120 T16121 arg1Of anti-CD3,plus
R8810 T16122 T16121 arg2Of anti-CD28,plus
R8811 T16124 T16119 arg2Of data,with
R8812 T16124 T16120 arg1Of data,anti-CD3
R8813 T16124 T16122 arg1Of data,anti-CD28
R8814 T16124 T16123 arg2Of data,(
R8815 T16124 T16126 arg2Of data,shown
R8816 T16126 T16125 arg1Of shown,not
R8817 T16127 T16123 arg3Of ),(
R8818 T16131 T16132 arg1Of NF-κB,is
R8819 T16132 T16129 arg2Of is,demonstrating
R8820 T16132 T16130 arg1Of is,that
R8821 T16137 T16132 arg2Of pathway,is
R8822 T16137 T16133 arg1Of pathway,the
R8823 T16137 T16134 arg1Of pathway,main
R8824 T16137 T16135 arg1Of pathway,intracellular
R8825 T16137 T16136 arg1Of pathway,signaling
R8826 T16137 T16138 arg1Of pathway,in
R8827 T16137 T16141 arg1Of pathway,by
R8828 T16140 T16138 arg2Of production,in
R8829 T16140 T16139 arg1Of production,IL-17
R8830 T16143 T16141 arg2Of PBMC,by
R8831 T16143 T16142 arg2Of PBMC,activated
R8832 T16143 T16144 arg1Of PBMC,from
R8833 T16145 T16144 arg2Of patients,from
R8834 T16145 T16146 arg1Of patients,with
R8835 T16147 T16146 arg2Of RA,with
R9423 T18418 T18419 arg1Of IL-17,was
R9424 T18418 T18421 arg2Of IL-17,described
R9425 T18421 T18419 arg2Of described,was
R9426 T18421 T18420 arg1Of described,first
R9427 T18421 T18422 arg1Of described,as
R9428 T18426 T18422 arg2Of product,as
R9429 T18426 T18423 arg1Of product,a
R9430 T18426 T18424 arg1Of product,T
R9431 T18426 T18425 arg1Of product,cell
R9432 T18426 T18427 arg1Of product,with
R9433 T18429 T18427 arg2Of properties,with
R9434 T18429 T18428 arg1Of properties,proinflammatory
R9435 T18429 T18430 arg1Of properties,[
R9436 T18431 T18430 arg2Of "5,22",[
R9437 T18432 T18430 arg3Of ],[
R9438 T18433 T18434 arg1Of RA,is
R9439 T18433 T18435 arg2Of RA,characterized
R9440 T18435 T18434 arg2Of characterized,is
R9441 T18435 T18449 arg1Of characterized,[
R9442 T18437 T18438 arg1Of hyperplasia,of
R9443 T18437 T18442 arg1Of hyperplasia,and
R9444 T18441 T18438 arg2Of cells,of
R9445 T18441 T18439 arg1Of cells,synovial
R9446 T18441 T18440 arg1Of cells,lining
R9447 T18442 T18435 arg1Of and,characterized
R9448 T18442 T18436 arg2Of and,by
R9449 T18445 T18442 arg2Of infiltration,and
R9450 T18445 T18443 arg1Of infiltration,an
R9451 T18445 T18444 arg1Of infiltration,intense
R9452 T18445 T18446 arg1Of infiltration,by
R9453 T18448 T18446 arg2Of cells,by
R9454 T18448 T18447 arg1Of cells,mononuclear
R9455 T18450 T18449 arg2Of 23,[
R9456 T18451 T18449 arg3Of ],[
R9457 T18453 T18452 arg1Of cytokines,Proinflammatory
R9458 T18453 T18455 arg1Of cytokines,as
R9459 T18453 T18459 arg1Of cytokines,are
R9460 T18453 T18460 arg1Of cytokines,abundant
R9461 T18455 T18454 arg1Of as,such
R9462 T18456 T18457 arg1Of IL-1,and
R9463 T18457 T18455 arg2Of and,as
R9464 T18458 T18457 arg2Of TNF-α,and
R9465 T18459 T18465 arg1Of are,whereas
R9466 T18460 T18459 arg2Of abundant,are
R9467 T18460 T18461 arg1Of abundant,in
R9468 T18463 T18461 arg2Of synovium,in
R9469 T18463 T18462 arg1Of synovium,rheumatoid
R9470 T18465 T18464 arg1Of whereas,","
R9471 T18468 T18467 arg1Of cell-derived,T
R9472 T18469 T18466 arg1Of cytokines,the
R9473 T18469 T18468 arg1Of cytokines,cell-derived
R9474 T18469 T18470 arg1Of cytokines,","
R9475 T18469 T18476 arg1Of cytokines,have
R9476 T18469 T18478 arg1Of cytokines,proved
R9477 T18469 T18479 arg1Of cytokines,difficult
R9478 T18469 T18481 arg2Of cytokines,detect
R9479 T18472 T18473 arg1Of IL-4,and
R9480 T18473 T18470 arg2Of and,","
R9481 T18473 T18471 arg1Of and,especially
R9482 T18474 T18473 arg2Of interferon-γ,and
R9483 T18478 T18465 arg2Of proved,whereas
R9484 T18478 T18475 arg1Of proved,","
R9485 T18478 T18476 arg2Of proved,have
R9486 T18478 T18477 arg1Of proved,often
R9487 T18479 T18478 arg2Of difficult,proved
R9488 T18481 T18479 arg2Of detect,difficult
R9489 T18481 T18480 arg1Of detect,to
R9490 T18481 T18482 arg1Of detect,in
R9491 T18481 T18485 arg1Of detect,[
R9492 T18484 T18482 arg2Of synovium,in
R9493 T18484 T18483 arg1Of synovium,RA
R9494 T18486 T18485 arg2Of 24,[
R9495 T18487 T18485 arg3Of ],[
R9496 T18490 T18489 arg1Of cells,T
R9497 T18490 T18491 arg1Of cells,may
R9498 T18490 T18492 arg1Of cells,have
R9499 T18492 T18488 arg2Of have,Although
R9500 T18492 T18491 arg2Of have,may
R9501 T18492 T18495 arg1Of have,in
R9502 T18494 T18492 arg2Of role,have
R9503 T18494 T18493 arg1Of role,a
R9504 T18497 T18495 arg2Of augmentation,in
R9505 T18497 T18496 arg1Of augmentation,the
R9506 T18497 T18498 arg1Of augmentation,of
R9507 T18501 T18498 arg2Of inflammation,of
R9508 T18501 T18499 arg1Of inflammation,rheumatoid
R9509 T18501 T18500 arg1Of inflammation,synovial
R9510 T18504 T18503 arg1Of lack,the
R9511 T18504 T18505 arg1Of lack,of
R9512 T18504 T18509 arg1Of lack,has
R9513 T18504 T18510 arg1Of lack,limited
R9514 T18508 T18505 arg2Of cytokines,of
R9515 T18508 T18506 arg1Of cytokines,T
R9516 T18508 T18507 arg1Of cytokines,cell-derived
R9517 T18510 T18488 arg1Of limited,Although
R9518 T18510 T18502 arg1Of limited,","
R9519 T18510 T18509 arg2Of limited,has
R9520 T18512 T18510 arg2Of importance,limited
R9521 T18512 T18511 arg1Of importance,its
R9522 T18515 T18513 arg2Of respect,In
R9523 T18515 T18514 arg1Of respect,this
R9524 T18517 T18518 arg1Of IL-17,is
R9525 T18517 T18519 arg1Of IL-17,appealing
R9526 T18519 T18513 arg1Of appealing,In
R9527 T18519 T18516 arg1Of appealing,","
R9528 T18519 T18518 arg2Of appealing,is
R9529 T18519 T18520 arg1Of appealing,because
R9530 T18521 T18522 arg1Of it,has
R9531 T18521 T18523 arg1Of it,been
R9532 T18521 T18524 arg2Of it,described
R9533 T18524 T18520 arg2Of described,because
R9534 T18524 T18522 arg2Of described,has
R9535 T18524 T18523 arg2Of described,been
R9536 T18524 T18525 arg1Of described,as
R9537 T18529 T18525 arg2Of cytokine,as
R9538 T18529 T18526 arg1Of cytokine,a
R9539 T18529 T18527 arg1Of cytokine,T
R9540 T18529 T18528 arg1Of cytokine,cell-derived
R9541 T18529 T18530 arg1Of cytokine,with
R9542 T18532 T18530 arg2Of properties,with
R9543 T18532 T18531 arg1Of properties,proinflammatory
R9544 T18535 T18533 arg2Of studies,In
R9545 T18535 T18534 arg1Of studies,our
R9546 T18537 T18538 arg1Of we,tried
R9547 T18537 T18540 arg1Of we,evaluate
R9548 T18538 T18533 arg1Of tried,In
R9549 T18538 T18536 arg1Of tried,","
R9550 T18538 T18550 arg1Of tried,and
R9551 T18540 T18538 arg2Of evaluate,tried
R9552 T18540 T18539 arg1Of evaluate,to
R9553 T18541 T18540 arg2Of how,evaluate
R9554 T18543 T18542 arg1Of production,IL-17
R9555 T18543 T18544 arg1Of production,is
R9556 T18543 T18545 arg2Of production,regulated
R9557 T18545 T18541 arg1Of regulated,how
R9558 T18545 T18544 arg2Of regulated,is
R9559 T18545 T18546 arg1Of regulated,in
R9560 T18548 T18546 arg2Of PBMC,in
R9561 T18548 T18547 arg1Of PBMC,RA
R9562 T18550 T18549 arg1Of and,","
R9563 T18553 T18551 arg1Of pathway,which
R9564 T18553 T18552 arg1Of pathway,signaling
R9565 T18553 T18555 arg2Of pathway,used
R9566 T18554 T18555 arg1Of it,used
R9567 T18555 T18550 arg2Of used,and
R9568 T18556 T18557 arg1Of Levels,of
R9569 T18556 T18559 arg1Of Levels,were
R9570 T18556 T18560 arg2Of Levels,found
R9571 T18556 T18562 arg1Of Levels,be
R9572 T18556 T18563 arg1Of Levels,higher
R9573 T18558 T18557 arg2Of IL-17,of
R9574 T18560 T18559 arg2Of found,were
R9575 T18562 T18560 arg3Of be,found
R9576 T18562 T18561 arg1Of be,to
R9577 T18563 T18562 arg2Of higher,be
R9578 T18563 T18564 arg1Of higher,in
R9579 T18563 T18568 arg1Of higher,than
R9580 T18567 T18564 arg2Of fluid,in
R9581 T18567 T18565 arg1Of fluid,RA
R9582 T18567 T18566 arg1Of fluid,synovial
R9583 T18569 T18568 arg2Of in,than
R9584 T18572 T18569 arg2Of fluid,in
R9585 T18572 T18570 arg1Of fluid,OA
R9586 T18572 T18571 arg1Of fluid,synovial
R9587 T18572 T18573 arg1Of fluid,[
R9588 T18574 T18573 arg2Of 15,[
R9589 T18575 T18573 arg3Of ],[
R9590 T18578 T18579 arg1Of there,are
R9591 T18579 T18576 arg1Of are,However
R9592 T18579 T18577 arg1Of are,","
R9593 T18581 T18579 arg2Of data,are
R9594 T18581 T18580 arg1Of data,few
R9595 T18581 T18582 arg1Of data,available
R9596 T18581 T18586 arg1Of data,that
R9597 T18581 T18587 arg1Of data,stimulate
R9598 T18582 T18583 arg1Of available,on
R9599 T18585 T18583 arg2Of agents,on
R9600 T18585 T18584 arg1Of agents,the
R9601 T18587 T18592 arg1Of stimulate,","
R9602 T18587 T18593 arg1Of stimulate,although
R9603 T18589 T18587 arg2Of production,stimulate
R9604 T18589 T18588 arg1Of production,IL-17
R9605 T18589 T18590 arg1Of production,in
R9606 T18591 T18590 arg2Of RA,in
R9607 T18596 T18594 arg1Of level,the
R9608 T18596 T18595 arg1Of level,highest
R9609 T18596 T18597 arg1Of level,of
R9610 T18596 T18600 arg1Of level,can
R9611 T18596 T18601 arg1Of level,be
R9612 T18596 T18602 arg2Of level,achieved
R9613 T18599 T18597 arg2Of production,of
R9614 T18599 T18598 arg1Of production,IL-17
R9615 T18602 T18593 arg2Of achieved,although
R9616 T18602 T18600 arg2Of achieved,can
R9617 T18602 T18601 arg2Of achieved,be
R9618 T18602 T18609 arg1Of achieved,[
R9619 T18605 T18602 arg1Of stimulation,achieved
R9620 T18605 T18603 arg2Of stimulation,by
R9621 T18605 T18604 arg1Of stimulation,anti-CD3/anti-CD28
R9622 T18605 T18606 arg1Of stimulation,in
R9623 T18608 T18606 arg2Of individuals,in
R9624 T18608 T18607 arg1Of individuals,healthy
R9625 T18610 T18609 arg2Of 25,[
R9626 T18611 T18609 arg3Of ],[
R9627 T18614 T18612 arg2Of experiments,In
R9628 T18614 T18613 arg1Of experiments,our
R9629 T18616 T18617 arg1Of PHA,as
R9630 T18616 T18632 arg1Of PHA,increased
R9631 T18618 T18622 arg1Of mitogens,as
R9632 T18622 T18617 arg2Of as,as
R9633 T18622 T18619 arg1Of as,","
R9634 T18622 T18620 arg1Of as,as
R9635 T18622 T18621 arg1Of as,well
R9636 T18622 T18624 arg1Of as,for
R9637 T18623 T18622 arg2Of anti-CD3/anti-CD28,as
R9638 T18625 T18624 arg2Of signaling,for
R9639 T18625 T18626 arg1Of signaling,through
R9640 T18630 T18626 arg2Of receptor,through
R9641 T18630 T18627 arg1Of receptor,the
R9642 T18630 T18628 arg1Of receptor,T
R9643 T18630 T18629 arg1Of receptor,cell
R9644 T18632 T18612 arg1Of increased,In
R9645 T18632 T18615 arg1Of increased,","
R9646 T18632 T18631 arg1Of increased,","
R9647 T18632 T18638 arg1Of increased,in
R9648 T18634 T18632 arg2Of production,increased
R9649 T18634 T18633 arg1Of production,IL-17
R9650 T18634 T18635 arg1Of production,from
R9651 T18637 T18635 arg2Of PBMC,from
R9652 T18637 T18636 arg1Of PBMC,RA
R9653 T18641 T18638 arg2Of manner,in
R9654 T18641 T18639 arg1Of manner,a
R9655 T18641 T18640 arg1Of manner,dose-dependent
R9656 T18642 T18643 arg1Of We,found
R9657 T18643 T18644 arg1Of found,","
R9658 T18643 T18645 arg1Of found,by
R9659 T18643 T18655 arg1Of found,","
R9660 T18649 T18645 arg2Of assay,by
R9661 T18649 T18646 arg1Of assay,a
R9662 T18649 T18647 arg1Of assay,cell
R9663 T18649 T18648 arg1Of assay,proliferation
R9664 T18649 T18650 arg1Of assay,(
R9665 T18651 T18650 arg2Of data,(
R9666 T18651 T18653 arg2Of data,shown
R9667 T18653 T18652 arg1Of shown,not
R9668 T18654 T18650 arg3Of ),(
R9669 T18658 T18657 arg1Of upregulation,this
R9670 T18658 T18659 arg1Of upregulation,of
R9671 T18658 T18661 arg1Of upregulation,might
R9672 T18658 T18662 arg1Of upregulation,be
R9673 T18658 T18664 arg1Of upregulation,to
R9674 T18658 T18670 arg1Of upregulation,to
R9675 T18660 T18659 arg2Of IL-17,of
R9676 T18662 T18643 arg2Of be,found
R9677 T18662 T18656 arg1Of be,that
R9678 T18662 T18661 arg2Of be,might
R9679 T18664 T18663 arg1Of to,due
R9680 T18664 T18669 arg1Of to,than
R9681 T18667 T18664 arg2Of activity,to
R9682 T18667 T18665 arg2Of activity,increased
R9683 T18667 T18666 arg1Of activity,cellular
R9684 T18669 T18662 arg2Of than,be
R9685 T18669 T18668 arg1Of than,rather
R9686 T18670 T18669 arg2Of to,than
R9687 T18672 T18670 arg2Of proliferation,to
R9688 T18672 T18671 arg1Of proliferation,cellular
R9689 T18673 T18674 arg1Of IL-17,is
R9690 T18673 T18675 arg2Of IL-17,produced
R9691 T18675 T18674 arg2Of produced,is
R9692 T18675 T18676 arg1Of produced,mainly
R9693 T18675 T18692 arg1Of produced,[
R9694 T18681 T18678 arg2Of cells,activated
R9695 T18681 T18679 arg1Of cells,CD4+
R9696 T18681 T18680 arg1Of cells,T
R9697 T18681 T18682 arg1Of cells,","
R9698 T18681 T18684 arg1Of cells,for
R9699 T18681 T18687 arg1Of cells,","
R9700 T18684 T18683 arg1Of for,especially
R9701 T18686 T18684 arg2Of cells,for
R9702 T18686 T18685 arg1Of cells,Th1/Th0
R9703 T18687 T18675 arg1Of ",",produced
R9704 T18687 T18677 arg2Of ",",by
R9705 T18691 T18687 arg2Of phenotype,","
R9706 T18691 T18688 arg1Of phenotype,not
R9707 T18691 T18689 arg1Of phenotype,the
R9708 T18691 T18690 arg1Of phenotype,Th2
R9709 T18693 T18692 arg2Of 26,[
R9710 T18694 T18692 arg3Of ],[
R9711 T18697 T18698 arg1Of it,can
R9712 T18697 T18700 arg1Of it,be
R9713 T18697 T18701 arg2Of it,produced
R9714 T18701 T18695 arg1Of produced,However
R9715 T18701 T18696 arg1Of produced,","
R9716 T18701 T18698 arg2Of produced,can
R9717 T18701 T18699 arg1Of produced,also
R9718 T18701 T18700 arg2Of produced,be
R9719 T18701 T18706 arg1Of produced,via
R9720 T18705 T18701 arg1Of cells,produced
R9721 T18705 T18702 arg2Of cells,by
R9722 T18705 T18703 arg1Of cells,CD8+
R9723 T18705 T18704 arg1Of cells,T
R9724 T18710 T18706 arg2Of mechanism,via
R9725 T18710 T18707 arg1Of mechanism,an
R9726 T18710 T18708 arg1Of mechanism,IL-23
R9727 T18710 T18709 arg1Of mechanism,triggering
R9728 T18710 T18711 arg1Of mechanism,in
R9729 T18714 T18711 arg2Of infection,in
R9730 T18714 T18712 arg1Of infection,Gram-negative
R9731 T18714 T18713 arg1Of infection,pulmonary
R9732 T18714 T18715 arg1Of infection,[
R9733 T18716 T18715 arg2Of 14,[
R9734 T18717 T18715 arg3Of ],[
R9735 T18719 T18718 arg2Of addition,In
R9736 T18722 T18721 arg1Of production,IL-17
R9737 T18722 T18723 arg1Of production,was
R9738 T18722 T18725 arg2Of production,augmented
R9739 T18725 T18718 arg1Of augmented,In
R9740 T18725 T18720 arg1Of augmented,","
R9741 T18725 T18723 arg2Of augmented,was
R9742 T18725 T18724 arg1Of augmented,significantly
R9743 T18728 T18725 arg1Of cells,augmented
R9744 T18728 T18726 arg2Of cells,by
R9745 T18728 T18727 arg1Of cells,T
R9746 T18728 T18729 arg1Of cells,recognizing
R9747 T18729 T18733 arg1Of recognizing,in
R9748 T18729 T18738 arg1Of recognizing,[
R9749 T18732 T18729 arg2Of collagen,recognizing
R9750 T18732 T18730 arg1Of collagen,type
R9751 T18732 T18731 arg1Of collagen,II
R9752 T18737 T18733 arg2Of model,in
R9753 T18737 T18734 arg1Of model,a
R9754 T18737 T18735 arg1Of model,collagen-induced
R9755 T18737 T18736 arg1Of model,arthritis
R9756 T18739 T18738 arg2Of 27,[
R9757 T18740 T18738 arg3Of ],[
R9758 T18743 T18741 arg1Of interaction,A
R9759 T18743 T18742 arg1Of interaction,complex
R9760 T18743 T18744 arg1Of interaction,between
R9761 T18743 T18750 arg1Of interaction,might
R9762 T18743 T18751 arg1Of interaction,produce
R9763 T18745 T18744 arg2Of cells,between
R9764 T18745 T18746 arg1Of cells,in
R9765 T18749 T18746 arg2Of joints,in
R9766 T18749 T18747 arg1Of joints,inflamed
R9767 T18749 T18748 arg1Of joints,RA
R9768 T18751 T18750 arg2Of produce,might
R9769 T18753 T18751 arg2Of variety,produce
R9770 T18753 T18752 arg1Of variety,a
R9771 T18753 T18754 arg1Of variety,of
R9772 T18756 T18757 arg1Of cytokines,and
R9773 T18757 T18754 arg2Of and,of
R9774 T18757 T18755 arg1Of and,proinflammatory
R9775 T18757 T18759 arg1Of and,","
R9776 T18757 T18760 arg1Of and,which
R9777 T18757 T18762 arg1Of and,activate
R9778 T18758 T18757 arg2Of chemokines,and
R9779 T18762 T18761 arg1Of activate,also
R9780 T18762 T18765 arg1Of activate,in
R9781 T18764 T18762 arg2Of cells,activate
R9782 T18764 T18763 arg1Of cells,other
R9783 T18767 T18765 arg2Of joints,in
R9784 T18767 T18766 arg1Of joints,the
R9785 T18769 T18768 arg2Of example,For
R9786 T18771 T18772 arg1Of IL-17,stimulates
R9787 T18772 T18768 arg1Of stimulates,For
R9788 T18772 T18770 arg1Of stimulates,","
R9789 T18774 T18772 arg2Of synoviocytes,stimulates
R9790 T18774 T18773 arg1Of synoviocytes,rheumatoid
R9791 T18774 T18776 arg1Of synoviocytes,secrete
R9792 T18776 T18772 arg3Of secrete,stimulates
R9793 T18776 T18775 arg1Of secrete,to
R9794 T18778 T18776 arg2Of cytokines,secrete
R9795 T18778 T18777 arg1Of cytokines,several
R9796 T18778 T18780 arg1Of cytokines,as
R9797 T18780 T18779 arg1Of as,such
R9798 T18781 T18782 arg1Of IL-6,","
R9799 T18782 T18784 arg1Of ",",and
R9800 T18783 T18782 arg2Of IL-8,","
R9801 T18784 T18792 arg1Of and,as
R9802 T18788 T18784 arg2Of gene,and
R9803 T18788 T18785 arg1Of gene,tumor
R9804 T18788 T18786 arg1Of gene,necrosis
R9805 T18788 T18787 arg1Of gene,factor-stimulated
R9806 T18788 T18789 arg1Of gene,6
R9807 T18792 T18780 arg2Of as,as
R9808 T18792 T18790 arg1Of as,as
R9809 T18792 T18791 arg1Of as,well
R9810 T18794 T18792 arg2Of E2,as
R9811 T18794 T18793 arg1Of E2,prostaglandin
R9812 T18794 T18796 arg1Of E2,vitro
R9813 T18794 T18797 arg1Of E2,[
R9814 T18796 T18795 arg1Of vitro,in
R9815 T18798 T18797 arg2Of "12,28,29",[
R9816 T18799 T18797 arg3Of ],[
R9817 T18800 T18801 arg1Of There,are
R9818 T18804 T18802 arg1Of few,as
R9819 T18804 T18803 arg1Of few,yet
R9820 T18805 T18801 arg2Of data,are
R9821 T18805 T18804 arg1Of data,few
R9822 T18805 T18806 arg1Of data,available
R9823 T18806 T18807 arg1Of available,on
R9824 T18809 T18807 arg2Of agents,on
R9825 T18809 T18808 arg1Of agents,the
R9826 T18809 T18810 arg1Of agents,that
R9827 T18809 T18811 arg1Of agents,stimulate
R9828 T18811 T18816 arg1Of stimulate,","
R9829 T18811 T18817 arg1Of stimulate,although
R9830 T18813 T18811 arg2Of production,stimulate
R9831 T18813 T18812 arg1Of production,IL-17
R9832 T18813 T18814 arg1Of production,in
R9833 T18815 T18814 arg2Of RA,in
R9834 T18819 T18818 arg1Of cytokines,some
R9835 T18819 T18820 arg1Of cytokines,(
R9836 T18819 T18825 arg1Of cytokines,have
R9837 T18819 T18826 arg1Of cytokines,been
R9838 T18819 T18827 arg2Of cytokines,known
R9839 T18819 T18829 arg1Of cytokines,regulate
R9840 T18821 T18822 arg1Of IL-15,and
R9841 T18822 T18820 arg2Of and,(
R9842 T18823 T18822 arg2Of IL-23,and
R9843 T18824 T18820 arg3Of ),(
R9844 T18827 T18817 arg2Of known,although
R9845 T18827 T18825 arg2Of known,have
R9846 T18827 T18826 arg2Of known,been
R9847 T18829 T18827 arg3Of regulate,known
R9848 T18829 T18828 arg1Of regulate,to
R9849 T18829 T18832 arg1Of regulate,[
R9850 T18831 T18829 arg2Of production,regulate
R9851 T18831 T18830 arg1Of production,IL-17
R9852 T18833 T18832 arg2Of "13,14",[
R9853 T18834 T18832 arg3Of ],[
R9854 T18835 T18837 arg1Of We,investigated
R9855 T18837 T18836 arg1Of investigated,therefore
R9856 T18837 T18865 modOf investigated,using
R9857 T18840 T18839 arg1Of vitro,in
R9858 T18841 T18840 arg1Of production,vitro
R9859 T18841 T18842 arg1Of production,of
R9860 T18841 T18844 arg1Of production,in
R9861 T18841 T18857 arg1Of production,as
R9862 T18843 T18842 arg2Of IL-17,of
R9863 T18846 T18844 arg2Of PBMC,in
R9864 T18846 T18845 arg1Of PBMC,RA
R9865 T18846 T18847 arg1Of PBMC,responding
R9866 T18847 T18848 arg1Of responding,to
R9867 T18850 T18848 arg2Of variety,to
R9868 T18850 T18849 arg1Of variety,a
R9869 T18850 T18851 arg1Of variety,of
R9870 T18852 T18853 arg1Of cytokines/chemokines,and
R9871 T18853 T18851 arg2Of and,of
R9872 T18854 T18853 arg2Of mitogens,and
R9873 T18857 T18837 arg2Of as,investigated
R9874 T18857 T18838 arg1Of as,the
R9875 T18857 T18855 arg1Of as,as
R9876 T18857 T18856 arg1Of as,well
R9877 T18860 T18858 arg1Of receptor,T
R9878 T18860 T18859 arg1Of receptor,cell
R9879 T18860 T18861 arg1Of receptor,(
R9880 T18862 T18861 arg2Of TCR,(
R9881 T18863 T18861 arg3Of ),(
R9882 T18864 T18857 arg2Of ligation,as
R9883 T18864 T18860 arg1Of ligation,receptor
R9884 T18866 T18865 arg2Of anti-CD3/anti-CD28,using
R9885 T18868 T18867 arg1Of studies,Our
R9886 T18868 T18869 arg1Of studies,demonstrated
R9887 T18871 T18872 arg1Of IL-15,and
R9888 T18872 T18876 arg1Of and,as
R9889 T18873 T18872 arg2Of MCP-1,and
R9890 T18876 T18874 arg1Of as,as
R9891 T18876 T18875 arg1Of as,well
R9892 T18876 T18880 arg1Of as,increased
R9893 T18878 T18876 arg2Of ligation,as
R9894 T18878 T18877 arg1Of ligation,TCR
R9895 T18880 T18869 arg2Of increased,demonstrated
R9896 T18880 T18870 arg1Of increased,that
R9897 T18880 T18879 arg1Of increased,significantly
R9898 T18882 T18880 arg2Of production,increased
R9899 T18882 T18881 arg1Of production,the
R9900 T18882 T18883 arg1Of production,of
R9901 T18882 T18885 arg1Of production,in
R9902 T18884 T18883 arg2Of IL-17,of
R9903 T18887 T18885 arg2Of PBMC,in
R9904 T18887 T18886 arg1Of PBMC,RA
R9905 T18889 T18890 arg1Of IL-15,or
R9906 T18890 T18888 arg1Of or,Adding
R9907 T18890 T18892 arg1Of or,to
R9908 T18890 T18895 arg1Of or,augmented
R9909 T18891 T18890 arg2Of MCP-1,or
R9910 T18894 T18892 arg2Of ligation,to
R9911 T18894 T18893 arg1Of ligation,TCR
R9912 T18895 T18899 arg1Of augmented,markedly
R9913 T18897 T18895 arg2Of production,augmented
R9914 T18897 T18896 arg1Of production,IL-17
R9915 T18899 T18898 arg1Of markedly,more
R9916 T18901 T18900 arg2Of contrast,In
R9917 T18903 T18904 arg1Of IL-1,and
R9918 T18904 T18906 arg1Of and,","
R9919 T18904 T18907 arg1Of and,which
R9920 T18904 T18908 arg1Of and,are
R9921 T18904 T18909 arg2Of and,known
R9922 T18904 T18911 arg1Of and,have
R9923 T18904 T18916 arg1Of and,be
R9924 T18904 T18917 arg2Of and,increased
R9925 T18904 T18922 arg1Of and,did
R9926 T18904 T18924 arg1Of and,affect
R9927 T18905 T18904 arg2Of TNF-α,and
R9928 T18909 T18908 arg2Of known,are
R9929 T18911 T18910 arg1Of have,to
R9930 T18911 T18914 arg1Of have,and
R9931 T18913 T18911 arg2Of properties,have
R9932 T18913 T18912 arg1Of properties,proinflammatory
R9933 T18914 T18909 arg3Of and,known
R9934 T18917 T18914 arg2Of increased,and
R9935 T18917 T18915 arg1Of increased,to
R9936 T18917 T18916 arg2Of increased,be
R9937 T18917 T18918 arg1Of increased,in
R9938 T18920 T18918 arg2Of joints,in
R9939 T18920 T18919 arg1Of joints,RA
R9940 T18924 T18900 arg1Of affect,In
R9941 T18924 T18902 arg1Of affect,","
R9942 T18924 T18921 arg1Of affect,","
R9943 T18924 T18922 arg2Of affect,did
R9944 T18924 T18923 arg1Of affect,not
R9945 T18926 T18924 arg2Of production,affect
R9946 T18926 T18925 arg1Of production,IL-17
R9947 T18928 T18927 arg1Of data,Our
R9948 T18928 T18929 arg1Of data,were
R9949 T18928 T18930 arg1Of data,consistent
R9950 T18930 T18929 arg2Of consistent,were
R9951 T18930 T18931 arg1Of consistent,with
R9952 T18934 T18931 arg2Of report,with
R9953 T18934 T18932 arg1Of report,a
R9954 T18934 T18933 arg1Of report,recent
R9955 T18936 T18937 arg1Of IL-15,triggered
R9956 T18937 T18945 arg1Of triggered,but
R9957 T18939 T18938 arg1Of vitro,in
R9958 T18941 T18937 arg2Of production,triggered
R9959 T18941 T18939 arg1Of production,vitro
R9960 T18941 T18940 arg1Of production,IL-17
R9961 T18941 T18942 arg1Of production,in
R9962 T18943 T18942 arg2Of PBMC,in
R9963 T18945 T18934 arg2Of but,report
R9964 T18945 T18935 arg1Of but,that
R9965 T18945 T18944 arg1Of but,","
R9966 T18946 T18947 arg1Of TNF-α,did
R9967 T18946 T18949 arg1Of TNF-α,do
R9968 T18946 T18950 arg1Of TNF-α,so
R9969 T18949 T18945 arg2Of do,but
R9970 T18949 T18947 arg2Of do,did
R9971 T18949 T18948 arg1Of do,not
R9972 T18949 T18951 arg1Of do,[
R9973 T18950 T18949 arg2Of so,do
R9974 T18952 T18951 arg2Of 13,[
R9975 T18953 T18951 arg3Of ],[
R9976 T18955 T18956 arg1Of there,were
R9977 T18956 T18954 arg2Of were,Although
R9978 T18958 T18956 arg2Of data,were
R9979 T18958 T18957 arg1Of data,no
R9980 T18958 T18959 arg1Of data,that
R9981 T18960 T18962 arg1Of MCP-1,induces
R9982 T18962 T18959 arg2Of induces,that
R9983 T18962 T18961 arg1Of induces,directly
R9984 T18965 T18962 arg2Of activation,induces
R9985 T18965 T18963 arg1Of activation,T
R9986 T18965 T18964 arg1Of activation,cell
R9987 T18967 T18968 arg1Of it,might
R9988 T18967 T18969 arg1Of it,exert
R9989 T18969 T18954 arg1Of exert,Although
R9990 T18969 T18966 arg1Of exert,","
R9991 T18969 T18968 arg2Of exert,might
R9992 T18969 T18971 arg1Of exert,indirectly
R9993 T18969 T18972 arg1Of exert,on
R9994 T18969 T18975 arg1Of exert,through
R9995 T18970 T18969 arg2Of effects,exert
R9996 T18974 T18972 arg2Of cells,on
R9997 T18974 T18973 arg1Of cells,T
R9998 T18977 T18975 arg2Of activation,through
R9999 T18977 T18976 arg1Of activation,the
R10000 T18977 T18978 arg1Of activation,of
R10001 T18977 T18980 arg1Of activation,in
R10002 T18979 T18978 arg2Of monocytes/macrophages,of
R10003 T18982 T18980 arg2Of cultures,in
R10004 T18982 T18981 arg1Of cultures,PBMC
R10005 T18984 T18983 arg2Of reported,As
R10006 T18984 T18985 arg1Of reported,for
R10007 T18987 T18985 arg2Of individuals,for
R10008 T18987 T18986 arg1Of individuals,normal
R10009 T18987 T18988 arg1Of individuals,[
R10010 T18989 T18988 arg2Of 25,[
R10011 T18990 T18988 arg3Of ],[
R10012 T18994 T18992 arg1Of activation,T
R10013 T18994 T18993 arg1Of activation,cell
R10014 T18994 T18995 arg1Of activation,through
R10015 T18994 T18998 arg1Of activation,increases
R10016 T18996 T18995 arg2Of anti-CD3/anti-CD28,through
R10017 T18998 T18983 arg1Of increases,As
R10018 T18998 T18991 arg1Of increases,","
R10019 T18998 T18997 arg1Of increases,also
R10020 T19000 T18998 arg2Of induction,increases
R10021 T19000 T18999 arg1Of induction,IL-17
R10022 T19000 T19001 arg1Of induction,in
R10023 T19003 T19001 arg2Of PBMC,in
R10024 T19003 T19002 arg1Of PBMC,RA
R10025 T19007 T19005 arg1Of pathway,the
R10026 T19007 T19006 arg1Of pathway,signaling
R10027 T19007 T19008 arg1Of pathway,for
R10028 T19007 T19015 arg1Of pathway,has
R10029 T19007 T19016 arg1Of pathway,been
R10030 T19007 T19017 arg2Of pathway,documented
R10031 T19010 T19008 arg2Of induction,for
R10032 T19010 T19009 arg1Of induction,the
R10033 T19010 T19011 arg1Of induction,of
R10034 T19010 T19013 arg1Of induction,by
R10035 T19012 T19011 arg2Of cytokines/chemokines,of
R10036 T19014 T19013 arg2Of IL-17,by
R10037 T19017 T19004 arg2Of documented,Although
R10038 T19017 T19015 arg2Of documented,has
R10039 T19017 T19016 arg2Of documented,been
R10040 T19017 T19018 arg1Of documented,widely
R10041 T19017 T19019 arg1Of documented,[
R10042 T19020 T19019 arg2Of "8,30,31",[
R10043 T19021 T19019 arg3Of ],[
R10044 T19024 T19023 arg1Of data,no
R10045 T19024 T19025 arg1Of data,have
R10046 T19024 T19026 arg1Of data,been
R10047 T19024 T19027 arg1Of data,available
R10048 T19026 T19004 arg1Of been,Although
R10049 T19026 T19022 arg1Of been,","
R10050 T19026 T19025 arg2Of been,have
R10051 T19027 T19026 arg2Of available,been
R10052 T19027 T19028 arg1Of available,on
R10053 T19029 T19028 arg2Of how,on
R10054 T19031 T19030 arg1Of production,IL-17
R10055 T19031 T19032 arg1Of production,can
R10056 T19031 T19033 arg1Of production,be
R10057 T19031 T19034 arg2Of production,regulated
R10058 T19034 T19029 arg1Of regulated,how
R10059 T19034 T19032 arg2Of regulated,can
R10060 T19034 T19033 arg2Of regulated,be
R10061 T19038 T19034 arg1Of pathways,regulated
R10062 T19038 T19035 arg2Of pathways,by
R10063 T19038 T19036 arg1Of pathways,certain
R10064 T19038 T19037 arg1Of pathways,signaling
R10065 T19040 T19039 arg2Of using,By
R10066 T19043 T19040 arg2Of inhibitors,using
R10067 T19043 T19041 arg1Of inhibitors,signal
R10068 T19043 T19042 arg1Of inhibitors,transduction
R10069 T19045 T19040 arg1Of we,using
R10070 T19045 T19047 arg1Of we,examined
R10071 T19047 T19039 arg1Of examined,By
R10072 T19047 T19044 arg1Of examined,","
R10073 T19047 T19046 arg1Of examined,therefore
R10074 T19048 T19047 arg2Of which,examined
R10075 T19050 T19048 arg1Of pathway,which
R10076 T19050 T19049 arg1Of pathway,signaling
R10077 T19050 T19051 arg1Of pathway,was
R10078 T19050 T19053 arg2Of pathway,involved
R10079 T19053 T19051 arg2Of involved,was
R10080 T19053 T19052 arg1Of involved,mainly
R10081 T19053 T19054 arg1Of involved,in
R10082 T19056 T19054 arg2Of induction,in
R10083 T19056 T19055 arg1Of induction,the
R10084 T19056 T19057 arg1Of induction,of
R10085 T19056 T19059 arg1Of induction,in
R10086 T19058 T19057 arg2Of IL-17,of
R10087 T19061 T19059 arg2Of PBMC,in
R10088 T19061 T19060 arg1Of PBMC,RA
R10089 T19062 T19063 arg1Of We,identified
R10090 T19067 T19065 arg1Of production,anti-CD3-induced
R10091 T19067 T19066 arg1Of production,IL-17
R10092 T19067 T19068 arg1Of production,in
R10093 T19067 T19071 arg1Of production,was
R10094 T19067 T19073 arg2Of production,hampered
R10095 T19070 T19068 arg2Of PBMC,in
R10096 T19070 T19069 arg1Of PBMC,RA
R10097 T19073 T19063 arg2Of hampered,identified
R10098 T19073 T19064 arg1Of hampered,that
R10099 T19073 T19071 arg2Of hampered,was
R10100 T19073 T19072 arg1Of hampered,significantly
R10101 T19077 T19075 arg1Of inhibitor,the
R10102 T19077 T19076 arg1Of inhibitor,PI3K
R10103 T19078 T19077 arg1Of LY294002,inhibitor
R10104 T19078 T19079 arg1Of LY294002,and
R10105 T19079 T19073 arg1Of and,hampered
R10106 T19079 T19074 arg2Of and,by
R10107 T19079 T19084 arg1Of and,to
R10108 T19082 T19080 arg1Of inhibitor,the
R10109 T19082 T19081 arg1Of inhibitor,NF-κB
R10110 T19083 T19079 arg2Of PDTC,and
R10111 T19083 T19082 arg1Of PDTC,inhibitor
R10112 T19086 T19084 arg2Of levels,to
R10113 T19086 T19085 arg1Of levels,comparable
R10114 T19086 T19087 arg1Of levels,of
R10115 T19089 T19087 arg2Of production,of
R10116 T19089 T19088 arg1Of production,basal
R10117 T19089 T19090 arg1Of production,without
R10118 T19091 T19090 arg2Of stimulation,without
R10119 T19092 T19094 arg1Of We,found
R10120 T19094 T19093 arg1Of found,also
R10121 T19098 T19096 arg1Of production,anti-CD3-induced
R10122 T19098 T19097 arg1Of production,IL-17
R10123 T19098 T19099 arg1Of production,was
R10124 T19098 T19100 arg2Of production,downregulated
R10125 T19100 T19094 arg2Of downregulated,found
R10126 T19100 T19095 arg1Of downregulated,that
R10127 T19100 T19099 arg2Of downregulated,was
R10128 T19103 T19100 arg1Of addition,downregulated
R10129 T19103 T19101 arg2Of addition,by
R10130 T19103 T19102 arg1Of addition,the
R10131 T19103 T19104 arg1Of addition,of
R10132 T19105 T19104 arg2Of SB203580,of
R10133 T19105 T19106 arg1Of SB203580,","
R10134 T19110 T19106 arg2Of inhibitor,","
R10135 T19110 T19107 arg1Of inhibitor,a
R10136 T19110 T19108 arg1Of inhibitor,p38
R10137 T19110 T19109 arg1Of inhibitor,MAPK
R10138 T19113 T19112 arg2Of interesting,is
R10139 T19116 T19115 arg1Of series,a
R10140 T19116 T19117 arg1Of series,of
R10141 T19116 T19119 arg1Of series,supports
R10142 T19118 T19117 arg2Of evidence,of
R10143 T19119 T19111 arg1Of supports,It
R10144 T19119 T19112 arg1Of supports,is
R10145 T19119 T19113 arg1Of supports,interesting
R10146 T19119 T19114 arg1Of supports,that
R10147 T19120 T19119 arg2Of crosstalk,supports
R10148 T19120 T19121 arg1Of crosstalk,between
R10149 T19122 T19123 arg1Of NF-κB,and
R10150 T19123 T19121 arg2Of and,between
R10151 T19124 T19123 arg2Of p38,and
R10152 T19126 T19125 arg2Of myocytes,In
R10153 T19129 T19128 arg1Of kinase-β,IκB
R10154 T19129 T19130 arg1Of kinase-β,is
R10155 T19129 T19131 arg2Of kinase-β,activated
R10156 T19131 T19130 arg2Of activated,is
R10157 T19131 T19134 arg1Of activated,[
R10158 T19131 T19138 arg1Of activated,and
R10159 T19133 T19131 arg1Of p38,activated
R10160 T19133 T19132 arg2Of p38,by
R10161 T19135 T19134 arg2Of 32,[
R10162 T19136 T19134 arg3Of ],[
R10163 T19138 T19125 arg1Of and,In
R10164 T19138 T19127 arg1Of and,","
R10165 T19138 T19137 arg1Of and,","
R10166 T19141 T19139 arg1Of p38,the
R10167 T19141 T19140 arg2Of p38,activated
R10168 T19141 T19142 arg1Of p38,can
R10169 T19141 T19143 arg1Of p38,stimulate
R10170 T19143 T19138 arg2Of stimulate,and
R10171 T19143 T19142 arg2Of stimulate,can
R10172 T19143 T19145 arg1Of stimulate,by
R10173 T19144 T19143 arg2Of NF-κB,stimulate
R10174 T19147 T19145 arg2Of mechanism,by
R10175 T19147 T19146 arg1Of mechanism,a
R10176 T19147 T19148 arg1Of mechanism,involving
R10177 T19152 T19148 arg2Of protein,involving
R10178 T19152 T19149 arg1Of protein,histone
R10179 T19152 T19150 arg1Of protein,acetylase
R10180 T19152 T19151 arg1Of protein,p300/CREB-binding
R10181 T19152 T19153 arg1Of protein,[
R10182 T19154 T19153 arg2Of 33,[
R10183 T19155 T19153 arg3Of ],[
R10184 T19157 T19156 arg1Of results,Our
R10185 T19157 T19158 arg1Of results,revealed
R10186 T19162 T19160 arg1Of activation,p38
R10187 T19162 T19161 arg1Of activation,MAPK
R10188 T19162 T19163 arg1Of activation,was
R10189 T19162 T19165 arg2Of activation,affected
R10190 T19165 T19158 arg2Of affected,revealed
R10191 T19165 T19159 arg1Of affected,that
R10192 T19165 T19163 arg2Of affected,was
R10193 T19165 T19164 arg1Of affected,not
R10194 T19165 T19168 arg1Of affected,","
R10195 T19165 T19169 arg1Of affected,whereas
R10196 T19165 T19177 arg1Of affected,","
R10197 T19165 T19178 arg1Of affected,which
R10198 T19165 T19179 arg1Of affected,provided
R10199 T19167 T19165 arg1Of LY294002,affected
R10200 T19167 T19166 arg2Of LY294002,by
R10201 T19172 T19170 arg1Of activity,NF-κB
R10202 T19172 T19171 arg1Of activity,binding
R10203 T19172 T19173 arg1Of activity,was
R10204 T19172 T19174 arg2Of activity,decreased
R10205 T19174 T19169 arg2Of decreased,whereas
R10206 T19174 T19173 arg2Of decreased,was
R10207 T19176 T19174 arg1Of LY294002,decreased
R10208 T19176 T19175 arg2Of LY294002,by
R10209 T19181 T19179 arg2Of evidence,provided
R10210 T19181 T19180 arg1Of evidence,the
R10211 T19181 T19182 arg1Of evidence,for
R10212 T19186 T19182 arg2Of pathway,for
R10213 T19186 T19183 arg1Of pathway,a
R10214 T19186 T19184 arg1Of pathway,p38
R10215 T19186 T19185 arg1Of pathway,MAPK
R10216 T19186 T19187 arg1Of pathway,independent
R10217 T19187 T19188 arg1Of independent,of
R10218 T19190 T19188 arg2Of activation,of
R10219 T19190 T19189 arg1Of activation,PI3K
R10220 T19193 T19191 arg1Of relationship,The
R10221 T19193 T19192 arg1Of relationship,direct
R10222 T19193 T19194 arg1Of relationship,between
R10223 T19193 T19201 arg1Of relationship,needs
R10224 T19193 T19203 arg1Of relationship,be
R10225 T19193 T19204 arg2Of relationship,studied
R10226 T19195 T19196 arg1Of p38,and
R10227 T19196 T19194 arg2Of and,between
R10228 T19196 T19198 arg1Of and,for
R10229 T19197 T19196 arg2Of NF-κB,and
R10230 T19200 T19198 arg2Of production,for
R10231 T19200 T19199 arg1Of production,IL-17
R10232 T19204 T19201 arg2Of studied,needs
R10233 T19204 T19202 arg1Of studied,to
R10234 T19204 T19203 arg2Of studied,be
R10235 T19204 T19205 arg1Of studied,in
R10236 T19207 T19205 arg2Of experiments,in
R10237 T19207 T19206 arg1Of experiments,future
R10238 T19209 T19208 arg1Of search,The
R10239 T19209 T19210 arg1Of search,for
R10240 T19209 T19216 arg1Of search,seemed
R10241 T19209 T19218 arg1Of search,have
R10242 T19213 T19210 arg2Of pathway,for
R10243 T19213 T19211 arg1Of pathway,a
R10244 T19213 T19212 arg1Of pathway,downstream
R10245 T19213 T19214 arg1Of pathway,of
R10246 T19215 T19214 arg2Of PI3K,of
R10247 T19218 T19216 arg2Of have,seemed
R10248 T19218 T19217 arg1Of have,to
R10249 T19218 T19234 arg1Of have,at
R10250 T19221 T19219 arg1Of response,a
R10251 T19221 T19220 arg1Of response,maximal
R10252 T19221 T19222 arg1Of response,of
R10253 T19221 T19225 arg1Of response,at
R10254 T19221 T19228 arg1Of response,and
R10255 T19224 T19222 arg2Of activation,of
R10256 T19224 T19223 arg1Of activation,Akt
R10257 T19227 T19225 arg2Of hour,at
R10258 T19227 T19226 arg1Of hour,1
R10259 T19228 T19218 arg2Of and,have
R10260 T19231 T19228 arg2Of loss,and
R10261 T19231 T19229 arg1Of loss,a
R10262 T19231 T19230 arg1Of loss,gradual
R10263 T19231 T19232 arg1Of loss,of
R10264 T19233 T19232 arg2Of activity,of
R10265 T19236 T19234 arg2Of hours,at
R10266 T19236 T19235 arg1Of hours,2
R10267 T19238 T19237 arg1Of fact,The
R10268 T19238 T19246 arg1Of fact,suggests
R10269 T19240 T19241 arg1Of Akt,is
R10270 T19240 T19242 arg2Of Akt,phosphorylated
R10271 T19242 T19238 arg2Of phosphorylated,fact
R10272 T19242 T19239 arg1Of phosphorylated,that
R10273 T19242 T19241 arg2Of phosphorylated,is
R10274 T19242 T19243 arg1Of phosphorylated,upon
R10275 T19245 T19243 arg2Of stimulation,upon
R10276 T19245 T19244 arg1Of stimulation,anti-CD3
R10277 T19249 T19246 arg2Of involvement,suggests
R10278 T19249 T19247 arg1Of involvement,the
R10279 T19249 T19248 arg1Of involvement,possible
R10280 T19249 T19250 arg1Of involvement,of
R10281 T19249 T19252 arg1Of involvement,in
R10282 T19251 T19250 arg2Of PI3K,of
R10283 T19254 T19252 arg2Of induction,in
R10284 T19254 T19253 arg1Of induction,the
R10285 T19254 T19255 arg1Of induction,of
R10286 T19254 T19257 arg1Of induction,in
R10287 T19256 T19255 arg2Of IL-17,of
R10288 T19258 T19257 arg2Of RA,in
R10289 T19260 T19259 arg2Of view,In
R10290 T19260 T19261 arg1Of view,of
R10291 T19263 T19261 arg2Of fact,of
R10292 T19263 T19262 arg1Of fact,the
R10293 T19265 T19266 arg1Of NF-κB,was
R10294 T19265 T19268 arg2Of NF-κB,activated
R10295 T19268 T19263 arg2Of activated,fact
R10296 T19268 T19264 arg1Of activated,that
R10297 T19268 T19266 arg2Of activated,was
R10298 T19268 T19267 arg1Of activated,also
R10299 T19272 T19273 arg1Of IL-15,or
R10300 T19273 T19268 arg1Of or,activated
R10301 T19273 T19269 arg2Of or,by
R10302 T19273 T19270 arg1Of or,anti-CD3/anti-CD28
R10303 T19273 T19271 arg1Of or,","
R10304 T19273 T19275 arg1Of or,in
R10305 T19274 T19273 arg2Of mitogens,or
R10306 T19277 T19275 arg2Of experiments,in
R10307 T19277 T19276 arg1Of experiments,our
R10308 T19280 T19259 arg1Of is,In
R10309 T19280 T19278 arg1Of is,","
R10310 T19282 T19280 arg2Of likely,is
R10311 T19282 T19281 arg1Of likely,most
R10312 T19286 T19284 arg1Of pathway,the
R10313 T19286 T19285 arg1Of pathway,NF-κB
R10314 T19286 T19287 arg1Of pathway,is
R10315 T19286 T19290 arg2Of pathway,involved
R10316 T19290 T19279 arg1Of involved,it
R10317 T19290 T19280 arg1Of involved,is
R10318 T19290 T19282 arg1Of involved,likely
R10319 T19290 T19283 arg1Of involved,that
R10320 T19290 T19287 arg2Of involved,is
R10321 T19290 T19288 arg1Of involved,also
R10322 T19290 T19289 arg1Of involved,actively
R10323 T19290 T19291 arg1Of involved,in
R10324 T19293 T19291 arg2Of induction,in
R10325 T19293 T19292 arg1Of induction,the
R10326 T19293 T19294 arg1Of induction,of
R10327 T19293 T19296 arg1Of induction,in
R10328 T19295 T19294 arg2Of IL-17,of
R10329 T19298 T19296 arg2Of PBMC,in
R10330 T19298 T19297 arg1Of PBMC,RA
R10331 T19300 T19299 arg2Of contrast,In
R10332 T19306 T19302 arg1Of pathway,the
R10333 T19306 T19303 arg1Of pathway,AP-1
R10334 T19306 T19304 arg1Of pathway,signal
R10335 T19306 T19305 arg1Of pathway,transduction
R10336 T19306 T19307 arg1Of pathway,","
R10337 T19306 T19315 arg1Of pathway,was
R10338 T19306 T19317 arg2Of pathway,activated
R10339 T19311 T19307 arg2Of pathway,","
R10340 T19311 T19308 arg1Of pathway,another
R10341 T19311 T19309 arg1Of pathway,important
R10342 T19311 T19310 arg1Of pathway,signaling
R10343 T19311 T19312 arg1Of pathway,for
R10344 T19313 T19312 arg2Of cytokines/chemokines,for
R10345 T19317 T19299 arg1Of activated,In
R10346 T19317 T19301 arg1Of activated,","
R10347 T19317 T19314 arg1Of activated,","
R10348 T19317 T19315 arg2Of activated,was
R10349 T19317 T19316 arg1Of activated,not
R10350 T19317 T19318 arg1Of activated,in
R10351 T19320 T19318 arg2Of experiments,in
R10352 T19320 T19319 arg1Of experiments,our
R10353 T19320 T19321 arg1Of experiments,(
R10354 T19322 T19321 arg2Of data,(
R10355 T19322 T19324 arg2Of data,shown
R10356 T19324 T19323 arg1Of shown,not
R10357 T19325 T19321 arg3Of ),(
R10358 T19327 T19328 arg1Of PI3K,and
R10359 T19328 T19337 arg1Of and,have
R10360 T19328 T19338 arg1Of and,been
R10361 T19328 T19339 arg2Of and,reported
R10362 T19328 T19341 arg1Of and,deliver
R10363 T19332 T19328 arg2Of Akt,and
R10364 T19332 T19329 arg1Of Akt,its
R10365 T19332 T19330 arg1Of Akt,downstream
R10366 T19332 T19331 arg1Of Akt,kinase
R10367 T19332 T19333 arg1Of Akt,in
R10368 T19334 T19333 arg2Of association,in
R10369 T19334 T19335 arg1Of association,with
R10370 T19336 T19335 arg2Of NF-κB,with
R10371 T19339 T19326 arg2Of reported,Although
R10372 T19339 T19337 arg2Of reported,have
R10373 T19339 T19338 arg2Of reported,been
R10374 T19341 T19339 arg3Of deliver,reported
R10375 T19341 T19340 arg1Of deliver,to
R10376 T19341 T19344 arg1Of deliver,in
R10377 T19343 T19341 arg2Of signals,deliver
R10378 T19343 T19342 arg1Of signals,activating
R10379 T19347 T19344 arg2Of types,in
R10380 T19347 T19345 arg1Of types,many
R10381 T19347 T19346 arg1Of types,cell
R10382 T19350 T19349 arg1Of data,the
R10383 T19350 T19351 arg1Of data,on
R10384 T19350 T19356 arg1Of data,are
R10385 T19350 T19357 arg1Of data,lacking
R10386 T19353 T19351 arg2Of signal,on
R10387 T19353 T19352 arg1Of signal,the
R10388 T19353 T19354 arg1Of signal,inducing
R10389 T19355 T19354 arg2Of IL-17,inducing
R10390 T19357 T19326 arg1Of lacking,Although
R10391 T19357 T19348 arg1Of lacking,","
R10392 T19357 T19356 arg2Of lacking,are
R10393 T19359 T19358 arg1Of data,Our
R10394 T19359 T19361 arg1Of data,demonstrated
R10395 T19361 T19360 arg1Of demonstrated,clearly
R10396 T19363 T19364 arg1Of PI3K/Akt,and
R10397 T19364 T19368 arg1Of and,could
R10398 T19364 T19369 arg1Of and,be
R10399 T19367 T19364 arg2Of activation,and
R10400 T19367 T19365 arg1Of activation,resultant
R10401 T19367 T19366 arg1Of activation,NF-κB
R10402 T19369 T19361 arg2Of be,demonstrated
R10403 T19369 T19362 arg1Of be,that
R10404 T19369 T19368 arg2Of be,could
R10405 T19372 T19369 arg2Of arbitrator,be
R10406 T19372 T19370 arg1Of arbitrator,an
R10407 T19372 T19371 arg1Of arbitrator,important
R10408 T19372 T19373 arg1Of arbitrator,of
R10409 T19372 T19380 arg1Of arbitrator,","
R10410 T19372 T19381 arg1Of arbitrator,on
R10411 T19375 T19373 arg2Of upregulation,of
R10412 T19375 T19374 arg1Of upregulation,the
R10413 T19375 T19376 arg1Of upregulation,of
R10414 T19375 T19378 arg1Of upregulation,in
R10415 T19377 T19376 arg2Of IL-17,of
R10416 T19379 T19378 arg2Of RA,in
R10417 T19383 T19381 arg2Of basis,on
R10418 T19383 T19382 arg1Of basis,the
R10419 T19383 T19384 arg1Of basis,of
R10420 T19383 T19387 arg1Of basis,showing
R10421 T19386 T19384 arg2Of experiments,of
R10422 T19386 T19385 arg1Of experiments,our
R10423 T19389 T19387 arg2Of blocking,showing
R10424 T19389 T19388 arg1Of blocking,simultaneous
R10425 T19389 T19390 arg1Of blocking,of
R10426 T19389 T19394 arg1Of blocking,in
R10427 T19389 T19398 arg1Of blocking,by
R10428 T19393 T19390 arg2Of activity,of
R10429 T19393 T19391 arg1Of activity,NF-κB
R10430 T19393 T19392 arg1Of activity,binding
R10431 T19397 T19394 arg2Of promoter,in
R10432 T19397 T19395 arg1Of promoter,the
R10433 T19397 T19396 arg1Of promoter,IL-17
R10434 T19399 T19400 arg1Of PDTC,and
R10435 T19400 T19398 arg2Of and,by
R10436 T19401 T19400 arg2Of LY294002,and
R10437 T19402 T19406 arg1Of Considering,and
R10438 T19405 T19402 arg2Of activities,Considering
R10439 T19405 T19403 arg1Of activities,its
R10440 T19405 T19404 arg1Of activities,proinflammatory
R10441 T19406 T19426 arg1Of and,is
R10442 T19408 T19406 arg2Of induction,and
R10443 T19408 T19407 arg1Of induction,successful
R10444 T19408 T19409 arg1Of induction,of
R10445 T19408 T19411 arg1Of induction,for
R10446 T19410 T19409 arg2Of anti-IL-17,of
R10447 T19412 T19411 arg2Of ameliorating,for
R10448 T19412 T19414 arg1Of ameliorating,in
R10449 T19412 T19420 arg1Of ameliorating,","
R10450 T19412 T19421 modOf ameliorating,understanding
R10451 T19413 T19412 arg2Of arthritis,ameliorating
R10452 T19416 T19414 arg2Of models,in
R10453 T19416 T19415 arg1Of models,animal
R10454 T19416 T19417 arg1Of models,[
R10455 T19418 T19417 arg2Of "2,6,34-36",[
R10456 T19419 T19417 arg3Of ],[
R10457 T19425 T19421 arg2Of pathway,understanding
R10458 T19425 T19422 arg1Of pathway,the
R10459 T19425 T19423 arg1Of pathway,IL-17
R10460 T19425 T19424 arg1Of pathway,signaling
R10461 T19429 T19426 arg2Of element,is
R10462 T19429 T19427 arg1Of element,an
R10463 T19429 T19428 arg1Of element,important
R10464 T19429 T19430 arg1Of element,of
R10465 T19431 T19430 arg2Of developing,of
R10466 T19434 T19431 arg2Of therapies,developing
R10467 T19434 T19432 arg1Of therapies,new
R10468 T19434 T19433 arg2Of therapies,targeted
R10469 T19434 T19435 arg1Of therapies,in
R10470 T19436 T19435 arg2Of RA,in
R12078 T22227 T22228 arg1Of We,have
R12079 T22227 T22229 arg1Of We,detected
R12080 T22229 T22228 arg2Of detected,have
R12081 T22229 T22239 arg1Of detected,in
R12082 T22232 T22231 arg1Of pronounced,more
R12083 T22233 T22229 arg2Of production,detected
R12084 T22233 T22230 arg1Of production,a
R12085 T22233 T22232 arg1Of production,pronounced
R12086 T22233 T22234 arg1Of production,of
R12087 T22233 T22236 arg1Of production,from
R12088 T22235 T22234 arg2Of IL-17,of
R12089 T22238 T22236 arg2Of PBMC,from
R12090 T22238 T22237 arg1Of PBMC,RA
R12091 T22240 T22239 arg2Of response,in
R12092 T22240 T22241 arg1Of response,to
R12093 T22242 T22243 arg1Of IL-15,and
R12094 T22243 T22247 arg1Of and,as
R12095 T22244 T22243 arg2Of MCP-1,and
R12096 T22247 T22241 arg2Of as,to
R12097 T22247 T22245 arg1Of as,as
R12098 T22247 T22246 arg1Of as,well
R12099 T22248 T22247 arg2Of stimulation,as
R12100 T22248 T22249 arg1Of stimulation,by
R12101 T22250 T22249 arg2Of anti-CD3/anti-CD28,by
R12102 T22251 T22252 arg1Of We,have
R12103 T22251 T22254 arg1Of We,shown
R12104 T22254 T22252 arg2Of shown,have
R12105 T22254 T22253 arg1Of shown,also
R12106 T22256 T22257 arg1Of upregulation,of
R12107 T22256 T22259 arg1Of upregulation,by
R12108 T22256 T22263 arg1Of upregulation,in
R12109 T22256 T22267 arg1Of upregulation,could
R12110 T22256 T22268 arg1Of upregulation,be
R12111 T22258 T22257 arg2Of IL-17,of
R12112 T22262 T22259 arg2Of cells,by
R12113 T22262 T22260 arg2Of cells,activated
R12114 T22262 T22261 arg1Of cells,T
R12115 T22264 T22263 arg2Of patients,in
R12116 T22264 T22265 arg1Of patients,with
R12117 T22266 T22265 arg2Of RA,with
R12118 T22268 T22254 arg2Of be,shown
R12119 T22268 T22255 arg1Of be,that
R12120 T22268 T22267 arg2Of be,could
R12121 T22270 T22268 arg2Of result,be
R12122 T22270 T22269 arg1Of result,the
R12123 T22270 T22271 arg1Of result,of
R12124 T22270 T22273 arg1Of result,via
R12125 T22272 T22271 arg2Of activation,of
R12126 T22276 T22273 arg2Of pathway,via
R12127 T22276 T22274 arg1Of pathway,the
R12128 T22276 T22275 arg1Of pathway,PI3K/Akt
R12129 T22276 T22277 arg1Of pathway,with
R12130 T22280 T22277 arg2Of activation,with
R12131 T22280 T22278 arg1Of activation,resultant
R12132 T22280 T22279 arg1Of activation,NF-κB
R12133 T22282 T22281 arg1Of data,Our
R12134 T22282 T22283 arg1Of data,provide
R12135 T22282 T22298 arg1Of data,highlight
R12136 T22283 T22285 arg1Of provide,into
R12137 T22283 T22297 arg1Of provide,and
R12138 T22284 T22283 arg2Of insights,provide
R12139 T22287 T22285 arg2Of mechanisms,into
R12140 T22287 T22286 arg1Of mechanisms,cellular
R12141 T22287 T22288 arg1Of mechanisms,of
R12142 T22290 T22288 arg2Of regulation,of
R12143 T22290 T22289 arg1Of regulation,the
R12144 T22290 T22291 arg1Of regulation,of
R12145 T22293 T22291 arg2Of production,of
R12146 T22293 T22292 arg1Of production,IL-17
R12147 T22293 T22294 arg1Of production,in
R12148 T22295 T22294 arg2Of RA,in
R12149 T22297 T22296 arg1Of and,","
R12150 T22298 T22297 arg2Of highlight,and
R12151 T22300 T22298 arg2Of role,highlight
R12152 T22300 T22299 arg1Of role,the
R12153 T22300 T22301 arg1Of role,of
R12154 T22300 T22304 arg1Of role,","
R12155 T22300 T22305 arg1Of role,which
R12156 T22300 T22306 arg1Of role,has
R12157 T22300 T22308 arg1Of role,been
R12158 T22300 T22309 arg2Of role,neglected
R12159 T22303 T22301 arg2Of cells,of
R12160 T22303 T22302 arg1Of cells,T
R12161 T22309 T22306 arg2Of neglected,has
R12162 T22309 T22307 arg1Of neglected,hitherto
R12163 T22309 T22308 arg2Of neglected,been
R12164 T22309 T22310 arg1Of neglected,in
R12165 T22312 T22310 arg2Of pathogenesis,in
R12166 T22312 T22311 arg1Of pathogenesis,RA
R12167 T22316 T22314 arg2Of data,with
R12168 T22316 T22315 arg1Of data,recent
R12169 T22316 T22317 arg1Of data,on
R12170 T22320 T22317 arg2Of introduction,on
R12171 T22320 T22318 arg1Of introduction,the
R12172 T22320 T22319 arg1Of introduction,successful
R12173 T22320 T22321 arg1Of introduction,of
R12174 T22320 T22323 arg1Of introduction,in
R12175 T22322 T22321 arg2Of anti-IL-17,of
R12176 T22324 T22323 arg2Of RA,in
R12177 T22327 T22326 arg1Of results,our
R12178 T22327 T22328 arg1Of results,have
R12179 T22327 T22329 arg1Of results,added
R12180 T22329 T22313 arg1Of added,Together
R12181 T22329 T22314 arg1Of added,with
R12182 T22329 T22325 arg1Of added,","
R12183 T22329 T22328 arg2Of added,have
R12184 T22330 T22329 arg2Of information,added
R12185 T22330 T22331 arg1Of information,for
R12186 T22335 T22331 arg2Of targeting,for
R12187 T22335 T22332 arg1Of targeting,the
R12188 T22335 T22333 arg1Of targeting,future
R12189 T22335 T22334 arg1Of targeting,molecular
R12190 T22335 T22336 arg1Of targeting,of
R12191 T22338 T22337 arg1Of therapeutic,new
R12192 T22339 T22336 arg2Of applications,of
R12193 T22339 T22338 arg1Of applications,therapeutic
R12194 T22339 T22340 arg1Of applications,in
R12195 T22341 T22340 arg2Of RA,in

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T19454 24849-24854 Antecedent denotes TNF-α
T3466 3199-3203 Antecedent denotes IL-2
T3465 3166-3190 Anaphor denotes T cell-derived cytokines
T19453 24840-24844 Antecedent denotes IL-1
T19452 24856-24861 Anaphor denotes which
T19451 24357-24362 Antecedent denotes IL-23
T19450 24347-24352 Antecedent denotes IL-15
T19449 24331-24345 Anaphor denotes some cytokines
T19448 24144-24183 Antecedent denotes tumor necrosis factor-stimulated gene 6
T19447 24135-24139 Antecedent denotes IL-8
T19446 24129-24133 Antecedent denotes IL-6
T19445 24103-24120 Anaphor denotes several cytokines
T19444 23486-23491 Antecedent denotes IL-17
T19443 23605-23607 Anaphor denotes it
T19442 22349-22361 Antecedent denotes interferon-γ
T19441 22340-22344 Antecedent denotes IL-4
T19440 22303-22327 Anaphor denotes T cell-derived cytokines
T19439 22248-22253 Antecedent denotes TNF-α
T19438 22239-22243 Antecedent denotes IL-1
T19437 22205-22230 Anaphor denotes Proinflammatory cytokines
T3464 2762-2780 Antecedent denotes interleukin (IL)-1
T3463 2727-2756 Antecedent denotes tumor necrosis factor (TNF)-α
T3462 2810-2836 Anaphor denotes key inflammatory cytokines
T1028 584-598 Anaphor denotes some cytokines
T1029 600-605 Antecedent denotes IL-15
T1030 610-615 Antecedent denotes IL-23
T1031 1683-1688 Anaphor denotes their
T1032 1610-1615 Antecedent denotes IL-17
T3481 4453-4458 Antecedent denotes IL-17
T3480 4571-4573 Anaphor denotes it
T3479 4035-4040 Antecedent denotes IL-17
T3478 4217-4219 Anaphor denotes It
T3477 3920-3925 Antecedent denotes IL-17
T3476 3966-3968 Anaphor denotes it
T3475 3781-3786 Anaphor denotes which
T3474 3700-3705 Antecedent denotes IL-17
T3473 3720-3742 Anaphor denotes inflammatory cytokines
T3472 3325-3330 Antecedent denotes TNF-α
T3471 3315-3320 Antecedent denotes IL-18
T3470 3302-3306 Antecedent denotes IL-6
T3469 3296-3300 Antecedent denotes IL-1
T3468 3250-3285 Anaphor denotes macrophage and fibroblast cytokines
T3467 3208-3220 Antecedent denotes interferon-γ
R1749 T3480 T3481 boundBy it,IL-17
R10481 T19452 T19453 boundBy which,IL-1
R10482 T19452 T19454 boundBy which,TNF-α
R1060 T1028 T1029 boundBy some cytokines,IL-15
R1061 T1028 T1030 boundBy some cytokines,IL-23
R1062 T1031 T1032 boundBy their,IL-17
R1726 T3462 T3463 boundBy key inflammatory cytokines,tumor necrosis factor (TNF)-α
R1728 T3462 T3464 boundBy key inflammatory cytokines,interleukin (IL)-1
R1731 T3465 T3466 boundBy T cell-derived cytokines,IL-2
R1732 T3465 T3467 boundBy T cell-derived cytokines,interferon-γ
R1736 T3468 T3469 boundBy macrophage and fibroblast cytokines,IL-1
R1737 T3468 T3470 boundBy macrophage and fibroblast cytokines,IL-6
R1738 T3468 T3471 boundBy macrophage and fibroblast cytokines,IL-18
R1739 T3468 T3472 boundBy macrophage and fibroblast cytokines,TNF-α
R1741 T3473 T3474 boundBy inflammatory cytokines,IL-17
R1743 T3475 T3474 boundBy which,IL-17
R1744 T3476 T3477 boundBy it,IL-17
R1746 T3478 T3479 boundBy It,IL-17
R10471 T19437 T19438 boundBy Proinflammatory cytokines,IL-1
R10472 T19437 T19439 boundBy Proinflammatory cytokines,TNF-α
R10473 T19440 T19441 boundBy T cell-derived cytokines,IL-4
R10474 T19440 T19442 boundBy T cell-derived cytokines,interferon-γ
R10475 T19443 T19444 boundBy it,IL-17
R10476 T19445 T19446 boundBy several cytokines,IL-6
R10477 T19445 T19447 boundBy several cytokines,IL-8
R10478 T19445 T19448 boundBy several cytokines,tumor necrosis factor-stimulated gene 6
R10479 T19449 T19450 boundBy some cytokines,IL-15
R10480 T19449 T19451 boundBy some cytokines,IL-23

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T1033 10-24 Protein denotes interleukin-17
T1034 68-71 Protein denotes Akt
T22349 28675-28680 Protein denotes IL-17
T22348 28497-28502 Protein denotes IL-17
T22347 28380-28383 Protein denotes Akt
T22346 28286-28291 Protein denotes IL-17
T22345 28240-28244 Protein denotes CD28
T22344 28194-28199 Protein denotes MCP-1
T22343 28184-28189 Protein denotes IL-15
T22342 28150-28155 Protein denotes IL-17
T19476 24129-24133 Protein denotes IL-6
T19523 27996-28001 Protein denotes IL-17
T19522 27915-27920 Protein denotes IL-17
T19521 27802-27807 Protein denotes IL-17
T19520 27694-27699 Protein denotes IL-17
T19519 27603-27606 Protein denotes Akt
T19518 27544-27549 Protein denotes IL-17
T19517 27413-27416 Protein denotes Akt
T19516 27222-27226 Protein denotes AP-1
T19515 27187-27192 Protein denotes IL-17
T19514 27062-27067 Protein denotes IL-15
T19513 27056-27060 Protein denotes CD28
T19512 26976-26981 Protein denotes IL-17
T19511 26866-26869 Protein denotes Akt
T19510 26784-26787 Protein denotes Akt
T19509 26643-26648 Protein denotes IL-17
T19508 26349-26369 Protein denotes CREB-binding protein
T19507 26344-26348 Protein denotes p300
T19506 26220-26232 Protein denotes IκB kinase-β
T19505 26035-26040 Protein denotes IL-17
T19504 25822-25827 Protein denotes IL-17
T19503 25810-25813 Protein denotes CD3
T19502 25768-25773 Protein denotes IL-17
T19501 25576-25581 Protein denotes IL-17
T19500 25497-25502 Protein denotes IL-17
T19499 25393-25398 Protein denotes IL-17
T19498 25373-25377 Protein denotes CD28
T19497 25139-25144 Protein denotes MCP-1
T19496 25080-25085 Protein denotes TNF-α
T19495 25050-25055 Protein denotes IL-17
T19494 25025-25030 Protein denotes IL-15
T19493 24956-24961 Protein denotes IL-17
T19492 24849-24854 Protein denotes TNF-α
T19491 24840-24844 Protein denotes IL-1
T19490 24795-24800 Protein denotes IL-17
T19489 24763-24768 Protein denotes MCP-1
T19488 24754-24759 Protein denotes IL-15
T19487 24729-24734 Protein denotes IL-17
T19486 24657-24662 Protein denotes MCP-1
T19485 24647-24652 Protein denotes IL-15
T19484 24611-24615 Protein denotes CD28
T19483 24471-24476 Protein denotes IL-17
T19482 24392-24397 Protein denotes IL-17
T19481 24357-24362 Protein denotes IL-23
T19480 24347-24352 Protein denotes IL-15
T19479 24298-24303 Protein denotes IL-17
T19478 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T19477 24135-24139 Protein denotes IL-8
T19475 24051-24056 Protein denotes IL-17
T19474 23735-23740 Protein denotes IL-17
T19473 23652-23657 Protein denotes IL-23
T19472 23632-23635 Protein denotes CD8
T19471 23524-23527 Protein denotes CD4
T19470 23486-23491 Protein denotes IL-17
T19469 23397-23402 Protein denotes IL-17
T19468 23255-23260 Protein denotes IL-17
T19467 23197-23201 Protein denotes CD28
T19466 23155-23158 Protein denotes PHA
T19465 23089-23093 Protein denotes CD28
T19464 23039-23044 Protein denotes IL-17
T19463 22985-22990 Protein denotes IL-17
T19462 22835-22840 Protein denotes IL-17
T19461 22746-22751 Protein denotes IL-17
T19460 22594-22599 Protein denotes IL-17
T19459 22349-22361 Protein denotes interferon-γ
T19458 22340-22344 Protein denotes IL-4
T19457 22248-22253 Protein denotes TNF-α
T19456 22239-22243 Protein denotes IL-1
T19455 22004-22009 Protein denotes IL-17
T16167 21934-21939 Protein denotes IL-17
T16166 21839-21843 Protein denotes CD28
T16165 21769-21773 Protein denotes AP-1
T16164 21697-21702 Protein denotes IκB-α
T16163 21655-21660 Protein denotes IκB-α
T16162 21608-21613 Protein denotes IL-17
T16161 21346-21350 Protein denotes CD28
T16160 21227-21232 Protein denotes c-Rel
T16159 21200-21203 Protein denotes p50
T16158 21192-21195 Protein denotes p65
T16157 21081-21086 Protein denotes IL-17
T16156 21024-21028 Protein denotes CD28
T16155 20931-20936 Protein denotes IL-17
T16154 20806-20811 Protein denotes IL-17
T16153 20770-20775 Protein denotes IL-15
T16152 20762-20765 Protein denotes PHA
T16151 20740-20744 Protein denotes CD28
T16150 20627-20632 Protein denotes IL-17
T16149 20606-20610 Protein denotes AP-1
T16148 20585-20604 Protein denotes activator protein-1
T15132 20440-20443 Protein denotes Akt
T15131 20382-20387 Protein denotes IL-15
T15130 20358-20361 Protein denotes PHA
T15129 20300-20307 Protein denotes β-actin
T15128 20292-20295 Protein denotes Akt
T15127 20136-20139 Protein denotes Akt
T15126 20066-20069 Protein denotes Akt
T15125 19904-19907 Protein denotes Akt
T15124 19780-19785 Protein denotes IL-17
T15123 19745-19748 Protein denotes Akt
T14567 19577-19582 Protein denotes IL-17
T14566 19391-19396 Protein denotes IL-17
T14565 19334-19339 Protein denotes IL-17
T13853 19074-19079 Protein denotes IL-17
T13852 19007-19012 Protein denotes IL-17
T13851 18820-18825 Protein denotes IL-17
T13850 18674-18679 Protein denotes IL-17
T13849 18604-18615 Protein denotes calcineurin
T13848 18486-18491 Protein denotes IL-17
T13847 18197-18202 Protein denotes IL-17
T13846 18023-18028 Protein denotes IL-17
T13845 17917-17922 Protein denotes IL-17
T12843 17873-17879 Protein denotes MIP-1β
T12842 17852-17858 Protein denotes MIP-1α
T12841 17835-17839 Protein denotes IL-8
T12840 17707-17712 Protein denotes IL-17
T12839 17661-17665 Protein denotes IL-6
T12838 17641-17646 Protein denotes MCP-1
T12837 17591-17596 Protein denotes IL-17
T12836 17560-17565 Protein denotes TGF-β
T12835 17540-17545 Protein denotes IL-18
T12834 17522-17527 Protein denotes TNF-α
T12833 17504-17509 Protein denotes IL-1β
T12832 17473-17478 Protein denotes IL-15
T12831 17438-17443 Protein denotes IL-17
T12830 17393-17398 Protein denotes IL-17
T12829 17234-17239 Protein denotes IL-17
T12828 16984-16989 Protein denotes IL-17
T11959 16921-16925 Protein denotes CD28
T11958 16856-16861 Protein denotes IL-17
T11957 16841-16844 Protein denotes PHA
T11956 16728-16733 Protein denotes IL-17
T11955 16696-16700 Protein denotes CD28
T11954 16635-16640 Protein denotes IL-17
T11953 16463-16468 Protein denotes IL-17
T11952 16221-16226 Protein denotes IL-17
T11951 16209-16212 Protein denotes PHA
T11950 16199-16203 Protein denotes CD28
T11949 16130-16135 Protein denotes IL-17
T11378 15966-15969 Protein denotes PHA
T11377 15935-15940 Protein denotes IL-17
T11376 15809-15814 Protein denotes IL-17
T11375 15707-15712 Protein denotes IL-17
T11374 15619-15622 Protein denotes PHA
T11373 15493-15498 Protein denotes IL-17
T10413 14837-14842 Protein denotes c-Rel
T10412 14829-14832 Protein denotes p65
T10411 14824-14827 Protein denotes p50
T10410 13930-13935 Protein denotes IL-17
T9610 13304-13309 Protein denotes IκB-α
T9609 13296-13299 Protein denotes Akt
T9608 13276-13279 Protein denotes Akt
T9607 12549-12554 Protein denotes IκB-α
T9606 12541-12544 Protein denotes Akt
T9605 12521-12524 Protein denotes Akt
T8664 12480-12485 Protein denotes GAPDH
T8663 12457-12462 Protein denotes IL-17
T8662 12297-12302 Protein denotes IL-17
T8661 12287-12292 Protein denotes GAPDH
T8660 12186-12191 Protein denotes IL-17
T8659 12176-12181 Protein denotes GAPDH
T8658 11957-11962 Protein denotes GAPDH
T8657 11910-11915 Protein denotes GAPDH
T8656 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8655 11760-11765 Protein denotes IL-17
T8654 11497-11500 Protein denotes Taq
T8653 10920-10925 Protein denotes IL-17
T7773 10878-10883 Protein denotes IL-17
T7772 10631-10636 Protein denotes IL-17
T7771 10583-10588 Protein denotes IL-17
T7770 10140-10145 Protein denotes IL-17
T7769 9885-9890 Protein denotes IL-17
T7768 9669-9674 Protein denotes IL-17
T7767 9463-9468 Protein denotes IL-17
T7766 9457-9462 Protein denotes IL-17
T6934 9400-9403 Protein denotes CD4
T6933 9052-9055 Protein denotes CD4
T6932 8506-8509 Protein denotes CD4
T6931 8357-8360 Protein denotes CD4
T6930 8322-8325 Protein denotes CD4
T6279 7305-7310 Protein denotes IL-17
T5545 7106-7110 Protein denotes CD28
T5544 6921-6924 Protein denotes PHA
T5543 6901-6919 Protein denotes Phytohemagglutinin
T5542 6777-6781 Protein denotes IL-1
T5541 6767-6772 Protein denotes TNF-α
T5540 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5539 6602-6606 Protein denotes IL-8
T5538 6593-6597 Protein denotes IL-6
T5537 6585-6591 Protein denotes MIP-1β
T5536 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5535 6535-6540 Protein denotes MCP-1
T5534 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5533 6492-6497 Protein denotes IL-15
T5532 6485-6490 Protein denotes IL-18
T5531 6478-6483 Protein denotes IL-17
T3484 3199-3203 Protein denotes IL-2
T3483 2762-2780 Protein denotes interleukin (IL)-1
T3482 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T3514 5506-5511 Protein denotes IL-17
T3513 5419-5422 Protein denotes Akt
T3512 5241-5246 Protein denotes IL-17
T3511 5145-5150 Protein denotes IL-17
T3510 5010-5015 Protein denotes IL-17
T3509 4962-4965 Protein denotes CD8
T3508 4953-4956 Protein denotes CD4
T3507 4926-4931 Protein denotes IL-17
T3506 4887-4892 Protein denotes IL-23
T3505 4720-4725 Protein denotes IL-17
T3504 4628-4633 Protein denotes IL-15
T3503 4590-4593 Protein denotes CD4
T3502 4453-4458 Protein denotes IL-17
T3501 4263-4289 Protein denotes leukemia inhibitory factor
T3500 4254-4258 Protein denotes IL-6
T3499 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3498 4108-4113 Protein denotes RANKL
T3497 4035-4040 Protein denotes IL-17
T3496 3920-3925 Protein denotes IL-17
T3495 3914-3918 Protein denotes IL-1
T3494 3904-3909 Protein denotes TNF-α
T3493 3807-3811 Protein denotes IL-8
T3492 3798-3802 Protein denotes IL-6
T3491 3700-3705 Protein denotes IL-17
T3490 3325-3330 Protein denotes TNF-α
T3489 3315-3320 Protein denotes IL-18
T3488 3308-3313 Protein denotes IL-15
T3487 3302-3306 Protein denotes IL-6
T3486 3296-3300 Protein denotes IL-1
T3485 3208-3220 Protein denotes interferon-γ
T1067 2393-2398 Protein denotes IL-17
T1066 2311-2314 Protein denotes Akt
T1065 2219-2224 Protein denotes IL-17
T1064 2202-2203 Protein denotes 2
T1063 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T1062 2138-2157 Protein denotes activator protein-1
T1061 2062-2065 Protein denotes Akt
T1060 1912-1917 Protein denotes IL-17
T1059 1783-1786 Protein denotes Akt
T1058 1610-1615 Protein denotes IL-17
T1057 1572-1600 Protein denotes transforming growth factor-β
T1056 1563-1568 Protein denotes IL-18
T1055 1556-1561 Protein denotes IL-1β
T1054 1531-1554 Protein denotes tumor necrosis factor-α
T1053 1494-1499 Protein denotes IL-17
T1052 1477-1481 Protein denotes IL-6
T1051 1438-1472 Protein denotes monocyte chemoattractant protein-1
T1050 1431-1436 Protein denotes IL-15
T1049 1376-1379 Protein denotes PHA
T1048 1367-1371 Protein denotes CD28
T1047 1272-1277 Protein denotes IL-17
T1046 1126-1131 Protein denotes IL-17
T1045 1070-1073 Protein denotes PHA
T1044 1050-1068 Protein denotes phytohemagglutinin
T1043 1044-1048 Protein denotes CD28
T1042 870-875 Protein denotes IL-17
T1041 837-840 Protein denotes Akt
T1040 717-722 Protein denotes IL-17
T1039 648-653 Protein denotes IL-17
T1038 610-615 Protein denotes IL-23
T1037 600-605 Protein denotes IL-15
T1036 504-509 Protein denotes IL-17
T1035 273-292 Protein denotes Interleukin (IL)-17

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T22402 28240-28244 http://www.uniprot.org/uniprot/P10747 denotes CD28
T22401 28231-28234 http://www.uniprot.org/uniprot/P09693 denotes CD3
T22400 28231-28234 http://www.uniprot.org/uniprot/P07766 denotes CD3
T22399 28231-28234 http://www.uniprot.org/uniprot/P04234 denotes CD3
T22398 28231-28234 http://www.uniprot.org/uniprot/P20963 denotes CD3
T22397 28184-28189 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T22396 28675-28680 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T22395 28497-28502 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T22394 28286-28291 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T22393 28150-28155 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T20039 27222-27226 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T20038 27603-27606 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20037 27413-27416 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20036 26866-26869 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20035 26784-26787 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20034 27603-27606 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20033 27413-27416 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20008 23632-23635 http://www.uniprot.org/uniprot/P01732 denotes CD8
T20007 23524-23527 http://www.uniprot.org/uniprot/P01730 denotes CD4
T20006 27056-27060 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20005 25373-25377 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20004 24611-24615 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20003 23197-23201 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20002 23089-23093 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20001 27047-27050 http://www.uniprot.org/uniprot/P09693 denotes CD3
T20000 26898-26901 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19999 26023-26026 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19998 25810-25813 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19997 25364-25367 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19996 24602-24605 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19995 23188-23191 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19994 23080-23083 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19993 27047-27050 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19992 26898-26901 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19991 26023-26026 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19990 25810-25813 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19989 25364-25367 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19988 24602-24605 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19987 23188-23191 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19986 23080-23083 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19985 27047-27050 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19984 26898-26901 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19983 26023-26026 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19982 25810-25813 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19974 25810-25813 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19971 23188-23191 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19970 23080-23083 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19969 22349-22361 http://www.uniprot.org/uniprot/P01579 denotes interferon-γ
T19968 22340-22344 http://www.uniprot.org/uniprot/P05112 denotes IL-4
T19967 25080-25085 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19966 24849-24854 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19965 22248-22253 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19964 24849-24852 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19963 22248-22251 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19962 27996-28001 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19961 27915-27920 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19960 27802-27807 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19959 27694-27699 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19958 27544-27549 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19957 27187-27192 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19956 26976-26981 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19955 26643-26648 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19954 26035-26040 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19953 25822-25827 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19952 25768-25773 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19951 25576-25581 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19950 25497-25502 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19949 25393-25398 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19948 25050-25055 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19947 24956-24961 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19946 24795-24800 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19945 24729-24734 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19944 24471-24476 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19943 24392-24397 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19942 24298-24303 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19941 24051-24056 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19940 23735-23740 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19939 23486-23491 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19938 23397-23402 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19937 23255-23260 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19936 23039-23044 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19935 22985-22990 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19934 22835-22840 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19933 22746-22751 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19932 22594-22599 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19931 22004-22009 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16313 21227-21232 http://www.uniprot.org/uniprot/Q04864 denotes c-Rel
T16312 21200-21203 http://www.uniprot.org/uniprot/P19838 denotes p50
T16311 21192-21195 http://www.uniprot.org/uniprot/P21579 denotes p65
T16310 21192-21195 http://www.uniprot.org/uniprot/Q04206 denotes p65
T16309 20770-20775 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T16308 21839-21843 http://www.uniprot.org/uniprot/P10747 denotes CD28
T16307 21346-21350 http://www.uniprot.org/uniprot/P10747 denotes CD28
T16306 21024-21028 http://www.uniprot.org/uniprot/P10747 denotes CD28
T16305 20740-20744 http://www.uniprot.org/uniprot/P10747 denotes CD28
T16304 21825-21828 http://www.uniprot.org/uniprot/P09693 denotes CD3
T16303 21332-21335 http://www.uniprot.org/uniprot/P09693 denotes CD3
T16302 21010-21013 http://www.uniprot.org/uniprot/P09693 denotes CD3
T16301 20726-20729 http://www.uniprot.org/uniprot/P09693 denotes CD3
T16300 21825-21828 http://www.uniprot.org/uniprot/P07766 denotes CD3
T16299 21332-21335 http://www.uniprot.org/uniprot/P07766 denotes CD3
T16298 21010-21013 http://www.uniprot.org/uniprot/P07766 denotes CD3
T16297 20726-20729 http://www.uniprot.org/uniprot/P07766 denotes CD3
T16296 21825-21828 http://www.uniprot.org/uniprot/P04234 denotes CD3
T16295 21332-21335 http://www.uniprot.org/uniprot/P04234 denotes CD3
T16294 21010-21013 http://www.uniprot.org/uniprot/P04234 denotes CD3
T16293 20726-20729 http://www.uniprot.org/uniprot/P04234 denotes CD3
T16292 21825-21828 http://www.uniprot.org/uniprot/P20963 denotes CD3
T16291 21332-21335 http://www.uniprot.org/uniprot/P20963 denotes CD3
T16290 21010-21013 http://www.uniprot.org/uniprot/P20963 denotes CD3
T16289 20726-20729 http://www.uniprot.org/uniprot/P20963 denotes CD3
T16288 21934-21939 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16287 21608-21613 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16286 21081-21086 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16285 20931-20936 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16284 20806-20811 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16283 20627-20632 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T16282 21769-21773 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T16281 20603-20608 http://www.uniprot.org/uniprot/P05412 denotes 1 (AP
T15191 20382-20387 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T15190 20300-20307 http://www.uniprot.org/uniprot/P60709 denotes β-actin
T15189 20463-20466 http://www.uniprot.org/uniprot/P09693 denotes CD3
T15188 19983-19986 http://www.uniprot.org/uniprot/P09693 denotes CD3
T15187 19805-19808 http://www.uniprot.org/uniprot/P09693 denotes CD3
T15186 20463-20466 http://www.uniprot.org/uniprot/P07766 denotes CD3
T15185 19983-19986 http://www.uniprot.org/uniprot/P07766 denotes CD3
T15184 19805-19808 http://www.uniprot.org/uniprot/P07766 denotes CD3
T15183 20463-20466 http://www.uniprot.org/uniprot/P04234 denotes CD3
T15182 19983-19986 http://www.uniprot.org/uniprot/P04234 denotes CD3
T15181 19805-19808 http://www.uniprot.org/uniprot/P04234 denotes CD3
T15180 20463-20466 http://www.uniprot.org/uniprot/P20963 denotes CD3
T15179 19983-19986 http://www.uniprot.org/uniprot/P20963 denotes CD3
T15178 19805-19808 http://www.uniprot.org/uniprot/P20963 denotes CD3
T15177 19780-19785 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T14587 19628-19631 http://www.uniprot.org/uniprot/P09693 denotes CD3
T14586 19628-19631 http://www.uniprot.org/uniprot/P07766 denotes CD3
T14585 19628-19631 http://www.uniprot.org/uniprot/P04234 denotes CD3
T14584 19628-19631 http://www.uniprot.org/uniprot/P20963 denotes CD3
T14583 19577-19582 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T14582 19391-19396 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T14581 19334-19339 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13947 18474-18477 http://www.uniprot.org/uniprot/P09693 denotes CD3
T13946 18314-18317 http://www.uniprot.org/uniprot/P09693 denotes CD3
T13945 18185-18188 http://www.uniprot.org/uniprot/P09693 denotes CD3
T13944 18474-18477 http://www.uniprot.org/uniprot/P07766 denotes CD3
T13943 18314-18317 http://www.uniprot.org/uniprot/P07766 denotes CD3
T13942 18185-18188 http://www.uniprot.org/uniprot/P07766 denotes CD3
T13941 18474-18477 http://www.uniprot.org/uniprot/P04234 denotes CD3
T13940 18314-18317 http://www.uniprot.org/uniprot/P04234 denotes CD3
T13939 18185-18188 http://www.uniprot.org/uniprot/P04234 denotes CD3
T13938 18474-18477 http://www.uniprot.org/uniprot/P20963 denotes CD3
T13937 18314-18317 http://www.uniprot.org/uniprot/P20963 denotes CD3
T13936 18185-18188 http://www.uniprot.org/uniprot/P20963 denotes CD3
T13935 19074-19079 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13934 19007-19012 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13933 18820-18825 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13932 18674-18679 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13931 18486-18491 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13930 18197-18202 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13929 18023-18028 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T13928 17917-17922 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12924 17852-17858 http://www.uniprot.org/uniprot/P10147 denotes MIP-1α
T12923 17835-17839 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T12922 17661-17665 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T12921 17560-17565 http://www.uniprot.org/uniprot/P01137 denotes TGF-β
T12920 17522-17527 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T12919 17504-17509 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T12918 17473-17478 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T12917 17707-17712 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12916 17591-17596 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12915 17438-17443 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12914 17393-17398 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12913 17234-17239 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12912 16984-16989 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12056 16921-16925 http://www.uniprot.org/uniprot/P10747 denotes CD28
T12055 16696-16700 http://www.uniprot.org/uniprot/P10747 denotes CD28
T12054 16199-16203 http://www.uniprot.org/uniprot/P10747 denotes CD28
T12053 16908-16911 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12052 16773-16776 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12051 16710-16713 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12050 16605-16608 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12049 16574-16577 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12048 16373-16376 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12047 16183-16186 http://www.uniprot.org/uniprot/P09693 denotes CD3
T12046 16908-16911 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12045 16773-16776 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12044 16710-16713 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12043 16605-16608 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12042 16574-16577 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12041 16373-16376 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12040 16183-16186 http://www.uniprot.org/uniprot/P07766 denotes CD3
T12039 16908-16911 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12038 16773-16776 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12037 16710-16713 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12036 16605-16608 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12035 16574-16577 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12034 16373-16376 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12033 16183-16186 http://www.uniprot.org/uniprot/P04234 denotes CD3
T12032 16908-16911 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12031 16773-16776 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12030 16710-16713 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12029 16605-16608 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12028 16574-16577 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12027 16373-16376 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12026 16183-16186 http://www.uniprot.org/uniprot/P20963 denotes CD3
T12025 16856-16861 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12024 16728-16733 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12023 16635-16640 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12022 16463-16468 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12021 16221-16226 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T12020 16130-16135 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T11403 15935-15940 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T11402 15809-15814 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T11401 15707-15712 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T11400 15493-15498 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T10444 14837-14842 http://www.uniprot.org/uniprot/Q04864 denotes c-Rel
T10443 14829-14832 http://www.uniprot.org/uniprot/P21579 denotes p65
T10442 14829-14832 http://www.uniprot.org/uniprot/Q04206 denotes p65
T10441 14824-14827 http://www.uniprot.org/uniprot/P19838 denotes p50
T10440 13930-13935 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8726 11931-11934 http://www.uniprot.org/uniprot/P21980 denotes TGC
T8725 12480-12485 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T8724 12287-12292 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T8723 12176-12181 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T8722 11957-11962 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T8721 11910-11915 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T8720 11883-11908 http://www.uniprot.org/uniprot/P04406 denotes 3-phosphate dehydrogenase
T8719 11055-11058 http://www.uniprot.org/uniprot/P09693 denotes CD3
T8718 11055-11058 http://www.uniprot.org/uniprot/P07766 denotes CD3
T8717 11055-11058 http://www.uniprot.org/uniprot/P04234 denotes CD3
T8716 11055-11058 http://www.uniprot.org/uniprot/P20963 denotes CD3
T8715 12457-12462 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8714 12297-12302 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8713 12186-12191 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8712 11812-11817 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8711 11760-11765 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T8710 10920-10925 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7818 10878-10883 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7817 10631-10636 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7816 10583-10588 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7815 10140-10145 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7814 9885-9890 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7813 9669-9674 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7812 9463-9468 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T7811 9457-9462 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T6957 9400-9403 http://www.uniprot.org/uniprot/P01730 denotes CD4
T6956 9052-9055 http://www.uniprot.org/uniprot/P01730 denotes CD4
T6955 8506-8509 http://www.uniprot.org/uniprot/P01730 denotes CD4
T6954 8357-8360 http://www.uniprot.org/uniprot/P01730 denotes CD4
T6953 8322-8325 http://www.uniprot.org/uniprot/P01730 denotes CD4
T6285 7305-7310 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T5604 7106-7110 http://www.uniprot.org/uniprot/P10747 denotes CD28
T5603 7073-7076 http://www.uniprot.org/uniprot/P09693 denotes CD3
T5602 7073-7076 http://www.uniprot.org/uniprot/P07766 denotes CD3
T5601 7073-7076 http://www.uniprot.org/uniprot/P04234 denotes CD3
T5600 7073-7076 http://www.uniprot.org/uniprot/P20963 denotes CD3
T5599 6767-6772 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T5598 6705-6711 http://www.uniprot.org/uniprot/P01137 denotes TGF)-β
T5597 6602-6606 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T5596 6593-6597 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T5595 6589-6595 http://www.uniprot.org/uniprot/P01584 denotes 1β, IL
T5594 6576-6583 http://www.uniprot.org/uniprot/P10147 denotes MIP)-1α
T5593 6524-6538 http://www.uniprot.org/uniprot/Q5D1E8 denotes protein-1 (MCP
T5592 6524-6538 http://www.uniprot.org/uniprot/Q5D1E7 denotes protein-1 (MCP
T5591 6492-6497 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T5590 6478-6483 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3712 4962-4965 http://www.uniprot.org/uniprot/P10966 denotes CD8
T3711 4962-4965 http://www.uniprot.org/uniprot/P01732 denotes CD8
T3710 4953-4956 http://www.uniprot.org/uniprot/P01730 denotes CD4
T3709 4590-4593 http://www.uniprot.org/uniprot/P01730 denotes CD4
T3708 3807-3811 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T3707 5506-5511 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3706 5241-5246 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3705 5145-5150 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3704 5010-5015 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3703 4926-4931 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3702 4720-4725 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3701 4453-4458 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3700 4035-4040 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3699 3920-3925 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3698 3700-3705 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T3697 4628-4633 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T3696 3308-3313 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T3695 4254-4258 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3694 3798-3802 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3693 3302-3306 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3692 3208-3220 http://www.uniprot.org/uniprot/P01579 denotes interferon-γ
T3691 3199-3203 http://www.uniprot.org/uniprot/P60568 denotes IL-2
T3690 3904-3909 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T3689 3325-3330 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T3688 2750-2756 http://www.uniprot.org/uniprot/P01375 denotes TNF)-α
T3687 3325-3328 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3686 2750-2753 http://www.uniprot.org/uniprot/P01375 denotes TNF
T1273 1751-1754 http://www.uniprot.org/uniprot/P07766 denotes CD3
T1272 1333-1336 http://www.uniprot.org/uniprot/P07766 denotes CD3
T1271 1034-1037 http://www.uniprot.org/uniprot/P07766 denotes CD3
T1270 1751-1754 http://www.uniprot.org/uniprot/P04234 denotes CD3
T1269 1333-1336 http://www.uniprot.org/uniprot/P04234 denotes CD3
T1268 1034-1037 http://www.uniprot.org/uniprot/P04234 denotes CD3
T1267 1751-1754 http://www.uniprot.org/uniprot/P20963 denotes CD3
T1266 1333-1336 http://www.uniprot.org/uniprot/P20963 denotes CD3
T1265 1034-1037 http://www.uniprot.org/uniprot/P20963 denotes CD3
T1264 1431-1436 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T1263 600-605 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T1262 2393-2398 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1261 2219-2224 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1260 1912-1917 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1259 1610-1615 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1258 1494-1499 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1257 1272-1277 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1256 1126-1131 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1255 870-875 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1254 717-722 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1253 648-653 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1252 504-509 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T1251 286-292 http://www.uniprot.org/uniprot/Q16552 denotes IL)-17
T9650 12521-12524 http://www.uniprot.org/uniprot/P31751 denotes Akt
T9649 13296-13299 http://www.uniprot.org/uniprot/P31749 denotes Akt
T9648 13276-13279 http://www.uniprot.org/uniprot/P31749 denotes Akt
T9647 12541-12544 http://www.uniprot.org/uniprot/P31749 denotes Akt
T9646 12521-12524 http://www.uniprot.org/uniprot/P31749 denotes Akt
T1274 1034-1037 http://www.uniprot.org/uniprot/P09693 denotes CD3
T1275 1333-1336 http://www.uniprot.org/uniprot/P09693 denotes CD3
T1276 1751-1754 http://www.uniprot.org/uniprot/P09693 denotes CD3
T1277 1044-1048 http://www.uniprot.org/uniprot/P10747 denotes CD28
T1278 1367-1371 http://www.uniprot.org/uniprot/P10747 denotes CD28
T1279 1477-1481 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T1280 1556-1561 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T9661 12585-12588 http://www.uniprot.org/uniprot/P09693 denotes CD3
T9660 12585-12588 http://www.uniprot.org/uniprot/P07766 denotes CD3
T9659 12585-12588 http://www.uniprot.org/uniprot/P04234 denotes CD3
T9658 12585-12588 http://www.uniprot.org/uniprot/P20963 denotes CD3
T9657 13296-13299 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T9656 13276-13279 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T9655 12541-12544 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T9654 12521-12524 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T9653 13296-13299 http://www.uniprot.org/uniprot/P31751 denotes Akt
T9652 13276-13279 http://www.uniprot.org/uniprot/P31751 denotes Akt
T9651 12541-12544 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19973 25364-25367 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19972 24602-24605 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19977 27047-27050 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19976 26898-26901 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19975 26023-26026 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19981 25364-25367 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19980 24602-24605 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19979 23188-23191 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19978 23080-23083 http://www.uniprot.org/uniprot/P04234 denotes CD3
T20032 26866-26869 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20031 26784-26787 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20030 27603-27606 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20029 27413-27416 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20028 26866-26869 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20027 26784-26787 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20026 26349-26369 http://www.uniprot.org/uniprot/Q92793 denotes CREB-binding protein
T20025 26349-26353 http://www.uniprot.org/uniprot/Q02930 denotes CREB
T20024 26349-26353 http://www.uniprot.org/uniprot/P15336 denotes CREB
T20023 26349-26353 http://www.uniprot.org/uniprot/O43889 denotes CREB
T20022 26349-26353 http://www.uniprot.org/uniprot/P16220 denotes CREB
T20021 26349-26353 http://www.uniprot.org/uniprot/Q8TEY5 denotes CREB
T20020 26349-26353 http://www.uniprot.org/uniprot/P18848 denotes CREB
T20019 26344-26348 http://www.uniprot.org/uniprot/Q09472 denotes p300
T20018 26220-26230 http://www.uniprot.org/uniprot/Q60680-2 denotes IκB kinase
T20017 26220-26230 http://www.uniprot.org/uniprot/O15111 denotes IκB kinase
T20016 27062-27067 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20015 25025-25030 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20014 24754-24759 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20013 24647-24652 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20012 24347-24352 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20011 24135-24139 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T20010 24129-24133 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T20009 23632-23635 http://www.uniprot.org/uniprot/P10966 denotes CD8

UBERON-AE

Id Subject Object Predicate Lexical cue
T17223 22897-22911 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluid
T17222 22871-22885 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluid
T9218 13150-13154 http://purl.obolibrary.org/obo/UBERON_0001913 denotes milk
T7260 9765-9770 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T5917 7654-7659 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T5916 7402-7407 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2234 4754-4759 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2233 4462-4477 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluids
T184 905-910 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T543 10-35 http://purl.obolibrary.org/obo/GO_0032740 denotes interleukin-17 production
T545 10-35 http://purl.obolibrary.org/obo/GO_0032620 denotes interleukin-17 production
T552 10-35 http://purl.obolibrary.org/obo/GO_0032700 denotes interleukin-17 production
T553 10-35 http://purl.obolibrary.org/obo/GO_0032660 denotes interleukin-17 production
T22211 28596-28608 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T22210 28483-28493 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22209 28456-28464 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T22208 28375-28379 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T22207 28194-28197 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T22206 28172-28189 http://purl.obolibrary.org/obo/GO_0071350 denotes response to IL-15
T22205 28172-28189 http://purl.obolibrary.org/obo/GO_0070672 denotes response to IL-15
T22204 28497-28513 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T22203 28136-28155 http://purl.obolibrary.org/obo/GO_0032620 denotes production of IL-17
T22202 28497-28513 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T22201 28136-28155 http://purl.obolibrary.org/obo/GO_0032660 denotes production of IL-17
T18233 24209-24211 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T18232 24209-24211 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T18231 24209-24211 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T18230 24209-24211 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T18229 24209-24211 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T18228 24209-24211 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T18227 24209-24211 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T18226 24209-24211 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T18225 24209-24211 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T18224 24209-24211 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T18223 24209-24211 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T18222 24209-24211 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T18221 24150-24158 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T18220 24150-24158 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T18219 24150-24158 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T18218 24150-24158 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T18217 23462-23470 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T18216 23429-23437 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T18215 23328-23346 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T18214 27227-27246 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T18213 25650-25669 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T18212 27274-27291 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18211 25710-25727 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18210 25434-25451 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18209 22798-22815 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18208 28002-28011 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18207 27274-27283 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18206 25710-25719 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18205 25621-25630 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18204 25434-25443 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18203 23206-23215 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18202 22798-22807 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18201 26643-26659 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18200 26035-26051 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18199 25822-25838 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18198 25576-25592 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18197 25050-25066 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18196 24956-24972 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18195 24795-24811 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18194 24392-24408 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18193 24298-24314 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18192 23735-23751 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18191 23255-23271 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18190 23039-23055 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18189 22985-23001 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18188 22746-22762 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18187 26643-26659 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18186 26035-26051 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18185 25822-25838 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18184 25576-25592 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18183 25050-25066 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18182 24956-24972 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18181 24795-24811 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18180 24392-24408 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18179 24298-24314 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18178 23735-23751 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18177 23255-23271 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18176 23039-23055 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18175 22985-23001 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18174 22746-22762 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18173 22498-22510 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18268 27621-27637 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18267 27274-27316 http://purl.obolibrary.org/obo/GO_0019221 denotes signaling pathway for cytokines/chemokines
T18266 27227-27254 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathway
T18265 27227-27254 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T18264 27227-27254 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T18263 27227-27254 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T18262 26406-26421 http://purl.obolibrary.org/obo/GO_0000187 denotes MAPK activation
T18261 26402-26421 http://purl.obolibrary.org/obo/GO_1900745 denotes p38 MAPK activation
T18260 26548-26552 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18259 26406-26410 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18258 26105-26109 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18257 26544-26547 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18256 26402-26405 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18255 26277-26280 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18254 26249-26252 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18253 26202-26205 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18252 26101-26104 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18251 27598-27602 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18250 27382-27386 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18249 26951-26955 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18248 26742-26746 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18247 26576-26580 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18246 25884-25888 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18245 27234-27246 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T18244 25657-25669 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T18243 25460-25482 http://purl.obolibrary.org/obo/GO_0042089 denotes induction of cytokines
T18242 25238-25261 http://purl.obolibrary.org/obo/GO_0042117 denotes activation of monocytes
T18241 25335-25350 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T18240 25164-25179 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T18239 25139-25142 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18238 24763-24766 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18237 24657-24660 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18236 24772-24775 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T18235 24674-24677 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T18234 24577-24580 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T15854 21937-21963 http://purl.obolibrary.org/obo/GO_0032740 denotes 17 production by activated
T15853 21934-21950 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T15852 21934-21950 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T15851 21682-21693 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T15850 21428-21432 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T15849 21307-21323 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15848 20690-20717 http://purl.obolibrary.org/obo/GO_1903265 denotes signaling pathway activated
T15847 20690-20717 http://purl.obolibrary.org/obo/GO_1902843 denotes signaling pathway activated
T15846 20690-20717 http://purl.obolibrary.org/obo/GO_1902046 denotes signaling pathway activated
T15845 20690-20717 http://purl.obolibrary.org/obo/GO_1900236 denotes signaling pathway activated
T15844 20690-20717 http://purl.obolibrary.org/obo/GO_0038084 denotes signaling pathway activated
T15843 20690-20717 http://purl.obolibrary.org/obo/GO_0009873 denotes signaling pathway activated
T15842 20690-20717 http://purl.obolibrary.org/obo/GO_1902204 denotes signaling pathway activated
T15841 20690-20717 http://purl.obolibrary.org/obo/GO_1901186 denotes signaling pathway activated
T15840 20690-20717 http://purl.obolibrary.org/obo/GO_0033211 denotes signaling pathway activated
T15839 20690-20717 http://purl.obolibrary.org/obo/GO_0009736 denotes signaling pathway activated
T15838 21913-21930 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T15837 20690-20707 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T15836 21913-21922 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15835 20690-20699 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15834 20676-20717 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signaling pathway activated
T15833 21899-21930 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signaling pathway
T15832 20676-20707 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signaling pathway
T15831 21899-21930 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signaling pathway
T15830 20676-20707 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signaling pathway
T15829 21899-21930 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathway
T15828 20676-20707 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathway
T15827 21899-21930 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signaling pathway
T15826 20676-20707 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signaling pathway
T14944 19780-19796 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T14943 19780-19796 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T14942 19756-19768 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T14941 19749-19776 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathway
T14940 19749-19776 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T14939 19749-19776 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T14938 19749-19776 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T14937 19749-19768 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T14936 19749-19755 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T14935 19859-19863 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14934 19740-19744 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14495 19659-19663 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14494 19473-19494 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T14493 19481-19494 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T14492 19432-19447 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T14491 19391-19407 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T14490 19391-19407 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13569 18745-18748 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13568 18739-18743 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13567 18713-18737 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T13566 18713-18737 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T13565 18713-18737 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T13564 18713-18737 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T13563 18680-18689 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T13562 18674-18689 http://purl.obolibrary.org/obo/GO_0072615 denotes IL-17 secretion
T13561 18604-18615 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T13560 18604-18615 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin
T13559 18435-18439 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T13558 18083-18111 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathways
T13557 18083-18111 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathways
T13556 18083-18111 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathways
T13555 18083-18111 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathways
T13554 18090-18102 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T13553 17944-17956 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T13552 18083-18102 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T13551 17937-17956 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T13550 18083-18089 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T13549 17937-17943 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T13548 19074-19090 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13547 19007-19023 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13546 18486-18502 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13545 18197-18213 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13544 18023-18039 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13543 17917-17933 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T13542 19074-19090 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13541 19007-19023 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13540 18486-18502 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13539 18197-18213 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13538 18023-18039 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T13537 17917-17933 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T12607 17641-17644 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T12606 17393-17409 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T12605 16984-17000 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T12604 17393-17409 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T12603 16984-17000 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T12602 16970-16980 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T11772 16404-16419 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T11771 16856-16872 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T11770 16635-16651 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T11769 16130-16146 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T11768 16856-16872 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T11767 16635-16651 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T11766 16130-16146 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T11230 15938-15962 http://purl.obolibrary.org/obo/GO_0032740 denotes 17 production stimulated
T11229 15815-15824 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T11228 15809-15824 http://purl.obolibrary.org/obo/GO_0072615 denotes IL-17 secretion
T11227 15678-15681 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T11226 15935-15951 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T11225 15493-15509 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T11224 15935-15951 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T11223 15493-15509 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T10185 14891-14893 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T10184 14217-14219 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T9370 12930-12932 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T9369 12756-12761 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T8638 11977-11980 http://purl.obolibrary.org/obo/GO_0047801 denotes CGT
T8637 11856-11859 http://purl.obolibrary.org/obo/GO_0004069 denotes AAT
T8636 11370-11383 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T8635 11281-11294 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T8634 10959-10972 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T8633 11362-11383 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T8632 10951-10972 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T6092 7714-7731 http://purl.obolibrary.org/obo/GO_1903803 denotes L-glutamine. Cell
T6091 7291-7310 http://purl.obolibrary.org/obo/GO_0032620 denotes Production of IL-17
T6090 7291-7310 http://purl.obolibrary.org/obo/GO_0032660 denotes Production of IL-17
T5358 7177-7179 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5357 6690-6696 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T5356 6535-6538 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T4880 6196-6200 http://purl.obolibrary.org/obo/GO_0007568 denotes ages
T4879 5894-5897 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T2826 5413-5417 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2825 5344-5375 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signaling pathway
T2824 5304-5316 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T2823 5120-5132 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T2822 5294-5324 http://purl.obolibrary.org/obo/GO_0036499 denotes signaling transduction pathway
T2821 5113-5140 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T2820 5294-5324 http://purl.obolibrary.org/obo/GO_0036500 denotes signaling transduction pathway
T2819 5113-5140 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T2818 5294-5324 http://purl.obolibrary.org/obo/GO_0036498 denotes signaling transduction pathway
T2817 5113-5140 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T2816 5358-5375 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T2815 5294-5316 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T2814 5113-5132 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T2813 5358-5367 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2812 5294-5303 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2811 5113-5119 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T2810 5344-5375 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signaling pathway
T2809 5099-5140 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signal transduction pathway
T2808 5344-5375 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signaling pathway
T2807 5099-5140 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signal transduction pathway
T2806 5344-5375 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathway
T2805 5294-5324 http://purl.obolibrary.org/obo/GO_0035556 denotes signaling transduction pathway
T2804 5099-5140 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signal transduction pathway
T2803 5344-5375 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signaling pathway
T2802 5099-5140 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signal transduction pathway
T2801 5025-5037 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2800 5241-5257 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2799 5145-5161 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2798 4926-4942 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2797 4720-4736 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T2777 4328-4330 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T2776 4240-4258 http://purl.obolibrary.org/obo/GO_0032675 denotes production of IL-6
T2775 4240-4258 http://purl.obolibrary.org/obo/GO_0032635 denotes production of IL-6
T2774 4072-4087 http://purl.obolibrary.org/obo/GO_0045453 denotes bone resorption
T2773 5569-5581 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2772 3424-3436 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2771 2980-2992 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2770 2873-2884 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2769 2733-2741 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T2768 2733-2741 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T2767 2733-2741 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T2766 2733-2741 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T573 2264-2283 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T572 684-702 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T571 2264-2270 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T570 2176-2182 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T569 684-693 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T568 670-702 http://purl.obolibrary.org/obo/GO_1902533 denotes intracellular signaling pathways
T567 670-702 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signaling pathways
T566 670-702 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signaling pathways
T565 2264-2292 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathways
T564 670-702 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signaling pathways
T563 670-702 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signaling pathways
T562 427-442 http://purl.obolibrary.org/obo/GO_0045453 denotes bone resorption
T561 333-355 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T560 230-242 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T559 2219-2235 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T558 1912-1928 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T557 1494-1510 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T556 870-886 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T555 717-733 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T554 648-664 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T551 2219-2235 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T550 1912-1928 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T549 1494-1510 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T548 870-886 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T547 717-733 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T546 648-664 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T544 1915-1941 http://purl.obolibrary.org/obo/GO_0032740 denotes 17 production by activated
T592 2271-2283 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T591 2264-2292 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathways
T590 2264-2292 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathways
T589 2264-2292 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathways
T588 2124-2155 http://purl.obolibrary.org/obo/GO_1902569 denotes inhibition of activator protein
T587 2005-2020 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB inhibitor
T586 2005-2020 http://purl.obolibrary.org/obo/GO_0032088 denotes NF-κB inhibitor
T585 1585-1591 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T584 1537-1545 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T583 1537-1545 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T582 1537-1545 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T581 1537-1545 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T580 1213-1226 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T579 1205-1226 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T578 856-866 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T577 2306-2310 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T576 2057-2061 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T575 1778-1782 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T574 831-835 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T2796 5241-5257 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2795 5145-5161 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2794 4926-4942 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2793 4720-4736 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T2792 4649-4670 http://purl.obolibrary.org/obo/GO_0042116 denotes activated macrophages
T2791 4406-4434 http://purl.obolibrary.org/obo/GO_0001773 denotes activate the dendritic cells
T2790 4406-4434 http://purl.obolibrary.org/obo/GO_0002270 denotes activate the dendritic cells
T2789 4406-4434 http://purl.obolibrary.org/obo/GO_0002266 denotes activate the dendritic cells
T2788 4328-4330 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T2787 4328-4330 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T2786 4328-4330 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T2785 4328-4330 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T2784 4328-4330 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T2783 4328-4330 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T2782 4328-4330 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T2781 4328-4330 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T2780 4328-4330 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T2779 4328-4330 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T2778 4328-4330 http://purl.obolibrary.org/obo/GO_0019787 denotes E2

GO-MF

Id Subject Object Predicate Lexical cue
T22356 28375-28379 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T22355 28194-28197 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T22354 28184-28189 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T22353 28675-28680 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T22352 28497-28502 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T22351 28286-28291 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T22350 28150-28155 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19605 27772-27785 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T19604 26460-26473 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T19603 26354-26369 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T19602 27778-27785 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19601 26466-26473 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19600 26354-26361 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19599 26349-26361 http://purl.obolibrary.org/obo/GO_0008140 denotes CREB-binding
T19598 26548-26552 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19597 26406-26410 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19596 26105-26109 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19595 26544-26547 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19594 26402-26405 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19593 26277-26280 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19592 26249-26252 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19591 26202-26205 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19590 26101-26104 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19589 27598-27602 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19588 27382-27386 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19587 26951-26955 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19586 26742-26746 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19585 26576-26580 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19584 25884-25888 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19583 25139-25142 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19582 24763-24766 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19581 24657-24660 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19580 27062-27067 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19579 25025-25030 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19578 24754-24759 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19577 24647-24652 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19576 24347-24352 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19575 24209-24211 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T19574 24209-24211 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T19573 24209-24211 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T19572 24209-24211 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T19571 24209-24211 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T19570 24209-24211 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T19569 24209-24211 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T19568 24209-24211 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T19567 24209-24211 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T19566 24209-24211 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T19565 24209-24211 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T19564 24209-24211 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T19563 24135-24139 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T19562 24129-24133 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T19561 24357-24362 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T19560 23652-23657 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T19559 22349-22361 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T19558 22340-22344 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T19557 24840-24844 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T19556 22239-22243 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T19555 27996-28001 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19554 27915-27920 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19553 27802-27807 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19552 27694-27699 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19551 27544-27549 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19550 27187-27192 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19549 26976-26981 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19548 26643-26648 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19547 26035-26040 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19546 25822-25827 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19545 25768-25773 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19544 25576-25581 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19543 25497-25502 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19542 25393-25398 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19541 25050-25055 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19540 24956-24961 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19539 24795-24800 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19538 24729-24734 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19537 24471-24476 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19536 24392-24397 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19535 24298-24303 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19534 24051-24056 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19533 23735-23740 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19532 23486-23491 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19531 23397-23402 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19530 23255-23260 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19529 23039-23044 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19528 22985-22990 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19527 22835-22840 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19526 22746-22751 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19525 22594-22599 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19524 22004-22009 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16181 21580-21591 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T16180 21428-21432 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T16179 21488-21501 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T16178 21061-21077 http://purl.obolibrary.org/obo/GO_0051059 denotes binding of NF-κB
T16177 21584-21591 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16176 21494-21501 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16175 21061-21068 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16174 20770-20775 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T16173 21934-21939 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16172 21608-21613 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16171 21081-21086 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16170 20931-20936 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16169 20806-20811 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16168 20627-20632 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T15136 20382-20387 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T15135 19780-19785 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T15134 19859-19863 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T15133 19740-19744 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T13867 18745-18748 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T13866 18739-18743 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T13865 18713-18737 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T13864 18604-18615 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T13863 18604-18615 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin
T13862 18435-18439 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T13861 19074-19079 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13860 19007-19012 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13859 18820-18825 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13858 18674-18679 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13857 18486-18491 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13856 18197-18202 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13855 18023-18028 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T13854 17917-17922 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11965 16856-16861 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11964 16728-16733 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11963 16635-16640 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11962 16463-16468 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11961 16221-16226 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11960 16130-16135 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11382 15935-15940 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11381 15809-15814 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11380 15707-15712 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T11379 15493-15498 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T10420 14790-14800 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T10419 14891-14893 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T10418 14217-14219 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T10417 13930-13935 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T10416 14373-14380 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10415 13904-13911 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10414 13788-13795 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T9613 13518-13528 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T9612 13257-13267 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T9611 12930-12932 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T8673 11977-11980 http://purl.obolibrary.org/obo/GO_0047801 denotes CGT
T8672 11856-11859 http://purl.obolibrary.org/obo/GO_0004069 denotes AAT
T8671 11808-11814 http://purl.obolibrary.org/obo/GO_0005135 denotes 3'; IL
T8670 12457-12462 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T8669 12297-12302 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T8668 12186-12191 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T8667 11812-11817 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T8666 11760-11765 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T8665 10920-10925 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7783 10121-10131 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T7782 9650-9660 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T7781 10878-10883 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7780 10631-10636 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7779 10583-10588 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7778 10140-10145 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7777 9885-9890 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7776 9669-9674 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7775 9463-9468 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T7774 9457-9462 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T6935 8622-8632 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6280 7305-7310 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T5555 7177-7179 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5554 7122-7130 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5553 7088-7096 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5552 6777-6781 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T5551 6602-6606 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T3551 5413-5417 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T3550 4887-4892 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T3549 4328-4330 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T3548 4328-4330 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T3547 4328-4330 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T3546 4328-4330 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T3545 4328-4330 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T3544 4328-4330 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T3543 4328-4330 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T3542 4328-4330 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T3541 4328-4330 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T3540 4328-4330 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T3539 4328-4330 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T3538 4328-4330 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T3537 4163-4169 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T3536 3807-3811 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T3535 5506-5511 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3534 5241-5246 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3533 5145-5150 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3532 5010-5015 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3531 4926-4931 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3530 4720-4725 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3529 4453-4458 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3528 4035-4040 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3527 3920-3925 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3526 3700-3705 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T3525 3315-3320 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T3524 4628-4633 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T3523 3308-3313 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T3522 4254-4258 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3521 3798-3802 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3520 3302-3306 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T3519 3208-3220 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T3518 3199-3203 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T3517 3914-3918 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T3516 3296-3300 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T3515 2775-2780 http://purl.obolibrary.org/obo/GO_0005149 denotes IL)-1
T1074 1272-1277 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1073 1126-1131 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1072 870-875 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1071 717-722 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1070 648-653 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1069 504-509 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1068 286-292 http://purl.obolibrary.org/obo/GO_0030367 denotes IL)-17
T1094 1894-1901 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1093 1890-1901 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T1092 1585-1600 http://purl.obolibrary.org/obo/GO_0005160 denotes growth factor-β
T1091 1563-1568 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T1090 1477-1481 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1089 1471-1479 http://purl.obolibrary.org/obo/GO_0005149 denotes 1 and IL
T1088 1755-1763 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T1087 1337-1345 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T1086 2306-2310 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T1085 2057-2061 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T1084 1778-1782 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T1083 831-835 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T1082 610-615 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T1081 1431-1436 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T1080 600-605 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T1079 2393-2398 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1078 2219-2224 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1077 1912-1917 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1076 1610-1615 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T1075 1494-1499 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T5550 6593-6597 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5549 6535-6538 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T5548 6492-6497 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T5547 6485-6490 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T5546 6478-6483 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T14571 19659-19663 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T14570 19577-19582 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T14569 19391-19396 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T14568 19334-19339 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12854 17835-17839 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T12853 17661-17665 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T12852 17641-17644 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T12851 17540-17545 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T12850 17473-17478 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T12849 17707-17712 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12848 17591-17596 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12847 17438-17443 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12846 17393-17398 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12845 17234-17239 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T12844 16984-16989 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17

GO-CC

Id Subject Object Predicate Lexical cue
T22358 28549-28554 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22357 28307-28312 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19615 27500-27504 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19618 24772-24775 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T19617 24674-24677 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T19616 24577-24580 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T12857 17247-17252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12856 17113-17118 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12855 17085-17089 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11968 16819-16823 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11967 16404-16408 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11966 16303-16308 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10896 14902-14906 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T10421 14790-14800 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T9621 13518-13528 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T9620 13257-13267 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T9619 13518-13528 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T9618 13257-13267 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T9617 13106-13114 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T9616 13023-13031 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T9615 12725-12730 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9614 12683-12687 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7787 10121-10131 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T7786 9650-9660 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T7785 10121-10131 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T7784 9650-9660 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6940 8622-8632 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6939 8622-8632 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6938 9406-9410 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6937 9164-9168 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6936 8329-8333 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6283 8173-8177 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6282 7541-7545 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6281 7316-7320 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3565 5344-5357 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T3564 5099-5112 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T3563 4969-4974 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3562 4772-4777 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3561 4597-4602 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3560 4429-4434 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3559 3986-3991 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3558 3774-3779 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3557 3649-3654 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3556 3534-3539 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3555 3411-3416 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19614 25335-25339 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19613 25164-25168 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19612 24562-24566 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19611 23328-23332 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19610 23230-23234 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19609 22650-22654 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19608 22526-22530 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19607 22305-22309 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19606 22037-22041 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T16183 21899-21912 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T16182 20676-20689 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T10422 14790-14800 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T5559 7122-7130 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5558 7088-7096 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5557 7122-7130 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5556 7088-7096 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T3554 2967-2972 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3553 2595-2600 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3552 2501-2506 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1095 670-683 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T1096 923-928 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1097 1309-1314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1098 1337-1345 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T1099 1755-1763 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T1100 1337-1345 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T1101 1755-1763 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T1102 2162-2175 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T10900 15284-15289 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10899 15247-15252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10898 15176-15180 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10897 14955-14959 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T528 0-149 Sentence denotes Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis
T22200 28610-28796 Sentence denotes Together with recent data on the successful introduction of anti-IL-17 in RA, our results have added information for the future molecular targeting of new therapeutic applications in RA.
T22199 28425-28609 Sentence denotes Our data provide insights into cellular mechanisms of the regulation of IL-17 production in RA, and highlight the role of T cells, which has hitherto been neglected in RA pathogenesis.
T22198 28246-28424 Sentence denotes We have also shown that upregulation of IL-17 by activated T cells in patients with RA could be the result of activation via the PI3K/Akt pathway with resultant NF-κB activation.
T22197 28101-28245 Sentence denotes We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation by anti-CD3/anti-CD28.
T18172 27839-28087 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.
T18171 27563-27838 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T18170 27373-27562 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T18169 27205-27372 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T18168 26989-27204 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T18167 26852-26988 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T18166 26703-26851 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T18165 26593-26702 Sentence denotes The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments.
T18164 26376-26592 Sentence denotes Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation.
T18163 26207-26375 Sentence denotes In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33].
T18162 26121-26206 Sentence denotes It is interesting that a series of evidence supports crosstalk between NF-κB and p38.
T18161 25999-26120 Sentence denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor.
T18160 25786-25998 Sentence denotes We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation.
T18159 25641-25785 Sentence denotes By using signal transduction inhibitors, we therefore examined which signaling pathway was mainly involved in the induction of IL-17 in RA PBMC.
T18158 25421-25640 Sentence denotes Although the signaling pathway for the induction of cytokines/chemokines by IL-17 has been documented widely [8,30,31], no data have been available on how IL-17 production can be regulated by certain signaling pathways.
T18157 25292-25420 Sentence denotes As reported for normal individuals [25], T cell activation through anti-CD3/anti-CD28 also increases IL-17 induction in RA PBMC.
T18156 25106-25291 Sentence denotes Although there were no data that MCP-1 directly induces T cell activation, it might exert effects indirectly on T cells through the activation of monocytes/macrophages in PBMC cultures.
T18155 24974-25105 Sentence denotes Our data were consistent with a recent report that IL-15 triggered in vitro IL-17 production in PBMC, but TNF-α did not do so [13].
T18154 24827-24973 Sentence denotes In contrast, IL-1 and TNF-α, which are known to have proinflammatory properties and to be increased in RA joints, did not affect IL-17 production.
T18153 24747-24826 Sentence denotes Adding IL-15 or MCP-1 to TCR ligation augmented IL-17 production more markedly.
T18152 24617-24746 Sentence denotes Our studies demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC.
T18151 24418-24616 Sentence denotes We therefore investigated the in vitro production of IL-17 in RA PBMC responding to a variety of cytokines/chemokines and mitogens as well as T cell receptor (TCR) ligation using anti-CD3/anti-CD28.
T18150 24233-24417 Sentence denotes There are as yet few data available on the agents that stimulate IL-17 production in RA, although some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14].
T18149 24038-24232 Sentence denotes For example, IL-17 stimulates rheumatoid synoviocytes to secrete several cytokines such as IL-6, IL-8 and tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,28,29].
T18148 23864-24037 Sentence denotes A complex interaction between cells in inflamed RA joints might produce a variety of proinflammatory cytokines and chemokines, which also activate other cells in the joints.
T18147 23722-23863 Sentence denotes In addition, IL-17 production was significantly augmented by T cells recognizing type II collagen in a collagen-induced arthritis model [27].
T18146 23596-23721 Sentence denotes However, it can also be produced by CD8+ T cells via an IL-23 triggering mechanism in Gram-negative pulmonary infection [14].
T18145 23486-23595 Sentence denotes IL-17 is produced mainly by activated CD4+ T cells, especially for Th1/Th0 cells, not the Th2 phenotype [26].
T18144 23313-23485 Sentence denotes We found, by a cell proliferation assay (data not shown), that this upregulation of IL-17 might be due to increased cellular activity rather than to cellular proliferation.
T18143 23135-23312 Sentence denotes In our experiments, PHA as mitogens, as well as anti-CD3/anti-CD28 for signaling through the T cell receptor, increased IL-17 production from RA PBMC in a dose-dependent manner.
T18142 22918-23134 Sentence denotes However, there are few data available on the agents that stimulate IL-17 production in RA, although the highest level of IL-17 production can be achieved by anti-CD3/anti-CD28 stimulation in healthy individuals [25].
T18141 22825-22917 Sentence denotes Levels of IL-17 were found to be higher in RA synovial fluid than in OA synovial fluid [15].
T18140 22705-22824 Sentence denotes In our studies, we tried to evaluate how IL-17 production is regulated in RA PBMC, and which signaling pathway it used.
T18139 22577-22704 Sentence denotes In this respect, IL-17 is appealing because it has been described as a T cell-derived cytokine with proinflammatory properties.
T18138 22422-22576 Sentence denotes Although T cells may have a role in the augmentation of rheumatoid synovial inflammation, the lack of T cell-derived cytokines has limited its importance.
T18137 22205-22421 Sentence denotes Proinflammatory cytokines such as IL-1 and TNF-α are abundant in rheumatoid synovium, whereas the T cell-derived cytokines, especially IL-4 and interferon-γ, have often proved difficult to detect in RA synovium [24].
T18136 22090-22204 Sentence denotes RA is characterized by hyperplasia of synovial lining cells and an intense infiltration by mononuclear cells [23].
T18135 22004-22089 Sentence denotes IL-17 was first described as a T cell product with proinflammatory properties [5,22].
T15825 21752-21991 Sentence denotes In contrast, the AP-1 pathway was not activated by stimulation with anti-CD3 plus anti-CD28 (data not shown), demonstrating that NF-κB is the main intracellular signaling pathway in IL-17 production by activated PBMC from patients with RA.
T15824 21634-21751 Sentence denotes Western blotting for IκB-α showed inhibition of degradation of IκB-α by LY294002 and PDTC at the same time (Fig. 7c).
T15823 21556-21633 Sentence denotes Both agents block NF-κB DNA-binding activity in the IL-17 promoter (Fig. 7c).
T15822 21400-21555 Sentence denotes To confirm the link between PI3K activity and NF-κB, we performed EMSA to determine the NF-κB binding activity after treatment with both LY294002 and PDTC.
T15821 21243-21399 Sentence denotes In normal PBMC the same pattern was observed, but the degree of NF-κB activation by anti-CD3 plus anti-CD28 was less intense than that in RA PBMC (Fig. 7b).
T15820 21143-21242 Sentence denotes A supershift assay demonstrated shifted bands in p65 and p50 (lanes 3 and 4) not in c-Rel (lane 5).
T15819 20938-21142 Sentence denotes As shown in Fig. 7a, nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters in comparison with that of controls (lane 1).
T15818 20649-20937 Sentence denotes To investigate further the intracellular signaling pathway activated by anti-CD3 plus anti-CD28, concanavalin A, PHA and IL-15, and responsible for inducing IL-17 expression, we performed an electrophoretic mobility-shift assay (EMSA) of NF-κB recognition sites in the promoters of IL-17.
T15817 20557-20648 Sentence denotes Activation of the NF-κB and activator protein-1 (AP-1) pathway in the IL-17 promoter region
T14933 20358-20555 Sentence denotes PHA, concanavalin A and IL-15 also demonstrated the same effect on phosphorylated Akt as shown with anti-CD3, which was an inhibition by wortmannin and PDTC as well as by LY294002 (data not shown).
T14932 20260-20357 Sentence denotes In contrast, non-phosphorylated Akt and β-actin remained unchanged regardless of incubation time.
T14931 20084-20259 Sentence denotes However, after 30 min of incubation, phosphorylated Akt increased (lane 2), and the effect of inhibition by LY294002 (lane 3) reached a peak at 60 min, lasting to 120–240 min.
T14930 19929-20083 Sentence denotes As shown in Fig. 6, at 10 min of incubation with anti-CD3 (10 μg/ml) or LY294002 (20 μM), no difference in the amounts of phosphorylated Akt was observed.
T14929 19809-19928 Sentence denotes To determine downstream effector molecules of the PI3K pathway, we evaluated the activation of Akt by western blotting.
T14928 19726-19808 Sentence denotes Activation of PI3K/Akt signal transduction pathway on IL-17 production by anti-CD3
T14489 19536-19724 Sentence denotes We observed a dose-dependent increase in IL-17 mRNA transcripts after stimulation with anti-CD3; this was inhibited by the PI3K inhibitor LY294002 and by the NF-κB inhibitor PDTC (Fig. 5).
T14488 19367-19535 Sentence denotes To see whether enhanced IL-17 production could be regulated at a transcriptional level, semi-quantatitive reverse transcription–polymerase chain reaction was performed.
T14487 19334-19366 Sentence denotes IL-17 mRNA expression in RA PBMC
T13536 19220-19332 Sentence denotes Cytotoxic effects on PBMC by the chemical inhibitors at experimental concentrations were not observed (Fig. 4b).
T13535 19127-19219 Sentence denotes The other inhibitors in addition to PDTC and LY294002 showed the same pattern of inhibition.
T13534 19033-19126 Sentence denotes There were dose-dependent inhibitions of IL-17 production with chemical inhibitors (Fig. 4a).
T13533 18843-19032 Sentence denotes To evaluate the possibility of non-specific inhibition by the drug at high concentrations, we observed the dose response of PDTC and LY294002 for the inhibition of IL-17 production in PBMC.
T13532 18600-18842 Sentence denotes The calcineurin inhibitors cyclosporin A and FK506 also downregulated the IL-17 secretion as well as the mitogen-activated protein kinase (MAPK) p38 inhibitor SB203580 did, whereas rapamycin and PD98059 had no effect on IL-17 levels (Fig. 3).
T13531 18391-18599 Sentence denotes LY294002 and wortmannin, as an inhibitor of PI3K, also markedly inhibited the anti-CD3-induced IL-17 production in RA PBMC (98 ± 19 versus 38 ± 10 pg/ml [P < 0.005] and 48 ± 4 pg/ml [P < 0.05], respectively).
T13530 18127-18390 Sentence denotes As illustrated in Fig. 3, an significant decrease in anti-CD3-induced IL-17 production was observed when co-incubated with NF-κB inhibitor, PDTC and dexamethasone in comparison with anti-CD3 alone (38 ± 5 and 54 ± 11 versus 98 ± 19 pg/ml, respectively; P < 0.05).
T13529 17993-18126 Sentence denotes Having observed the increased IL-17 production in RA PBMC, it was important to know which signal transduction pathways were involved.
T13528 17903-17992 Sentence denotes Inhibition of IL-17 production by signal transduction inhibitors and anti-rheumatic drugs
T12601 17623-17901 Sentence denotes When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P < 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b).
T12600 17411-17622 Sentence denotes We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a).
T12599 17254-17410 Sentence denotes To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production.
T12598 17053-17253 Sentence denotes Because RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells.
T12597 16970-17052 Sentence denotes Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
T11765 16784-16968 Sentence denotes Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P < 0.05).
T11764 16579-16783 Sentence denotes As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone.
T11763 16494-16578 Sentence denotes On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3.
T11762 16213-16493 Sentence denotes Because IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown).
T11761 16120-16212 Sentence denotes Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA
T11222 15779-16118 Sentence denotes Although the amounts of basal IL-17 secretion were not different between RA, OA and normal controls (62 ± 31, 43 ± 19 and 43 ± 10 pg/ml, respectively), the IL-17 production stimulated by PHA was significantly higher in RA PBMC than in those from OA and controls (768 ± 295 versus 463 ± 211 pg/ml [P < 0.05] and 241 ± 29 pg/ml [P < 0.001]).
T11221 15581-15778 Sentence denotes PBMC were separated and cultured with PHA (5 μg/ml) from patients with RA, patients with OA, and age-matched normal controls; IL-17 levels were then determined in the culture supernatants (Fig. 1).
T11220 15493-15580 Sentence denotes IL-17 production in PBMC from patients with RA, patients with OA and normal individuals
T11017 15430-15482 Sentence denotes P values less than 0.05 were considered significant.
T11016 15354-15429 Sentence denotes Statistical analysis was performed with Student's t-test for matched pairs.
T11015 15319-15353 Sentence denotes Data are expressed as means ± SEM.
T11014 15298-15318 Sentence denotes Statistical analysis
T10824 15101-15296 Sentence denotes After incubation for 24 hours, the cells were harvested and the percentage cell viability was calculated with the formula 100 × (number of viable cells/number of both viable and dead cells) [21].
T10823 14951-15100 Sentence denotes For cell viability assays, the trypan blue dye exclusion method was used to evaluate the potential of direct cytotoxic effect of inhibitors on cells.
T10822 14902-14950 Sentence denotes Cell viability (Trypan blue dye exclusion assay)
T10180 14116-14226 Sentence denotes Unincorporated nucleotides were removed by NucTrap probe purification columns (Stratagene, La Jolla, CA, USA).
T10179 13858-14115 Sentence denotes Oligonucleotide probes encompassing the NF-κB binding site of the human IL-17 promoter (5'-ATG ACC TGG AAA TAC CCA AAA TTC-3') were generated by 5'-end labeling of the sense strand with [γ-32P]dATP (Amersham Pharmacia) and T4 polynucleotide kinase (TaKaRa).
T10178 13801-13857 Sentence denotes Nuclear proteins were extracted from about 5 × 106 PBMC.
T10177 13754-13800 Sentence denotes Gel mobility-shift assay of NF-κB binding site
T10183 14772-14900 Sentence denotes Rabbit polyclonal antibodies against NF-κB subunits p50, p65 and c-Rel were from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
T10182 14540-14771 Sentence denotes Samples were subjected to electrophoresis on nondenaturing 5% polyacrylamide gels in 0.5 × Tris-borate-EDTA buffer (pH 8.0) at 100 V. Gels were dried under vacuum and exposed to Kodak X-OMAT film at -70°C with intensifying screens.
T10181 14227-14539 Sentence denotes Nuclear extracts (2 μg of protein) were incubated with radiolabeled DNA probes (10 ng; 100,000 c.p.m.) for 30 min at room temperature in 20 μl of binding buffer consisting of 20 mM Tris-HCl, pH 7.9, 50 mM KCl, 1 mM dithiothreitol, 0.5 mM EDTA, 5% glycerol, 1 mg/ml BSA, 0.2% Nonidet P40 and 50 ng/μl poly(dI-dC).
T9368 13596-13752 Sentence denotes After TBS-T washing, hybridized bands were detected with the enhanced chemiluminescence (ECL) detection kit and Hyperfilm-ECL reagents (Amersham Pharmacia).
T9367 13079-13595 Sentence denotes For western hybridization, membrane was preincubated with 0.1% skimmed milk in TBS-T buffer (0.1% Tween 20 in Tris-buffered saline) at room temperature for 2 hours, then primary antibodies against Akt, phosphorylated Akt and IκB-α (Cell Signaling Technology Inc., Beverly, MA, USA), diluted 1:1000 in 5% BSA/TBS-T, were added and incubated overnight at 4°C. After washing four times with TBS-T, horseradish peroxidase-conjugated secondary antibodies were added and allowed to incubate for 1 hour at room temperature.
T9366 12940-13078 Sentence denotes Protein samples were separated by 10% SDS–PAGE and transferred to a nitrocellulose membrane (Amersham Pharmacia Biotech, Uppsala, Sweden).
T9365 12826-12939 Sentence denotes Protein concentrations in the supernatants were determined with the Bradford method (Bio-Rad, Hercules, CA, USA).
T9364 12648-12825 Sentence denotes After incubation for 1 hour, whole cell lysates were prepared from about 107 cells by homogenization in the lysis buffer, and centrifuged at 14,000 r.p.m. (19,000 g) for 15 min.
T9363 12555-12647 Sentence denotes PBMC were incubated with anti-CD3 (10 μg/ml) in the presence or absence of LY294002 (20 μM).
T9362 12496-12554 Sentence denotes Western blot analysis of Akt, phosphorylated Akt and IκB-α
T8631 12400-12494 Sentence denotes The level of mRNA expression was presented as a ratio of IL-17 PCR product over GAPDH product.
T8630 12008-12399 Sentence denotes Reactions were processed in a DNA thermal cycler (Perkin-Elmer Cetus, Norwalk, CT, USA) through cycles for 30 s of denaturation at 94°C, 1 min of annealing at 56°C for GAPDH and IL-17, followed by 1 min of elongation at 72°C. PCR rounds were repeated for 25 cycles each for both GAPDH and IL-17; this was determined as falling within the exponential phase of amplification for each molecule.
T8629 11688-12007 Sentence denotes The following sense and antisense primers for each molecules were used: IL-17 sense, 5'-ATG ACT CCT GGG AAG ACC TCA TTG-3'; IL-17 antisense, 5'-TTA GGC CAC ATG GTG GAC AAT CGG-3'; glyceraldehyde-3-phosphate dehydrogenase (GAPDH) sense, 5'-CGA TGC TGG GCG TGA GTA C-3'; GAPDH antisense, 5'-CGT TCA GCT CAG GGA TGA CC-3'.
T8628 11569-11687 Sentence denotes The reaction was performed in PCR buffer (1.5 mM MgCl2, 50 mM KCl, 10 mM Tris-HCl, pH 8.3) in a total volume of 25 μl.
T8627 11415-11568 Sentence denotes PCR amplification of cDNA aliquots was performed by adding 2.5 mM dNTPs, 2.5 U of Taq DNA polymerase (Takara) and 0.25 μM of sense and antisense primers.
T8626 11273-11414 Sentence denotes Reverse transcription of 2 μg of total mRNA was performed at 42°C using the Superscript™ reverse transcription system (Takara, Shiga, Japan).
T8625 11118-11272 Sentence denotes After 16 hours of incubation, mRNA was extracted with RNAzol B (Biotex Laboratories, Houston, TX, USA) in accordance with the manufacturer's instructions.
T8624 10999-11117 Sentence denotes PBMC were incubated with various concentrations of anti-CD3 in the presence or absence of inhibitors (LY294002, PDTC).
T8623 10902-10998 Sentence denotes Quantification of IL-17 mRNA by semiquantitative reverse transcription–polymerase chain reaction
T7501 10730-10900 Sentence denotes A standard curve was drawn by plotting optical density against the log of the concentration of recombinant cytokines, and used for determination of IL-17 in test samples.
T7500 10613-10729 Sentence denotes Recombinant human IL-17 diluted in culture medium was used as a calibration standard, ranging from 10 to 2000 pg/ml.
T7499 10564-10612 Sentence denotes The lower limit of IL-17 detection was 10 pg/ml.
T7498 10454-10563 Sentence denotes The reaction was stopped by the addition of 1 M NaOH and the optical density of each well was read at 405 nm.
T7497 10195-10453 Sentence denotes After washing, streptavidin–alkaline phosphate–horseradish peroxidase conjugate (Sigma) was incubated for 2 hours, then washed again and incubated with 1 mg/ml p-nitrophenyl phosphate (Sigma) dissolved in diethanolamine (Sigma) to develop the color reaction.
T7496 9986-10194 Sentence denotes Plates were washed four times with phosphate-buffered saline/Tween 20, and then incubated with 500 ng/ml biotinylated mouse monoclonal antibodies against IL-17 (R & D Systems) for 2 hours at room temperature.
T7495 9709-9985 Sentence denotes After blocking with phosphate-buffered saline/1% bovine serum albumin (BSA)/0.05% Tween 20 for 2 hours at room temperature (22–25°C), test samples and the standard recombinant IL-17 (R & D Systems) were added to the 96-well plate and incubated at room temperature for 2 hours.
T7494 9582-9708 Sentence denotes In brief, a 96-well plate (Nunc) was coated with 4 μg/ml monoclonal antibodies against IL-17 (R & D Systems) at 4°C overnight.
T7493 9463-9581 Sentence denotes IL-17 in culture supernatants was measured by sandwich enzyme-linked immunosorbent assay as described previously [20].
T7492 9420-9462 Sentence denotes Enzyme-linked immunosorbent assay of IL-17
T6733 9349-9418 Sentence denotes Most (more than 97%) of the isolated cells had the CD4 T cell marker.
T6732 9245-9348 Sentence denotes The purity of cells was assessed by flow cytometric analysis of stained cells on a FACS Vantage sorter.
T6731 9013-9244 Sentence denotes Alternatively, cells stained with anti-CD4–phycoerythrin were washed, magnetically labeled with anti-phycoerythrin microbeads (20 μl added to 80 μl of cell suspension; 15 min, 6–12°C), and magnetically separated as described above.
T6730 8913-9012 Sentence denotes Enriched cells were collected in two 0.5 ml aliquots from the column after removal from the magnet.
T6729 8839-8912 Sentence denotes Flow-through and two 1 ml washes were collected as the negative fraction.
T6728 8666-8838 Sentence denotes Cells were diluted in 2.5 ml of FBS staining buffer, pelleted, resuspended in 500 μl and magnetically separated, usually on an AutoMACS magnet fitted with a MACS MS column.
T6727 8501-8665 Sentence denotes Anti-CD4 microbeads (20 μl) were added and incubated for 15 min at 6–12°C. Saturating amounts of fluorochrome-conjugated antibodies were added for a further 10 min.
T6726 8446-8500 Sentence denotes PBMC were resuspended in 80 μl of FBS staining buffer.
T6725 8352-8445 Sentence denotes Anti-CD4 microbeads were used essentially as recommended by the manufacturer (Miltenyi) [19].
T6724 8322-8351 Sentence denotes CD4+ T-cell isolation by MACS
T6089 8239-8320 Sentence denotes All cultures were set up in triplicate, and results are expressed as means ± SEM.
T6088 8116-8238 Sentence denotes After incubation for 24 hours (unless otherwise stated), cell-free media were collected and stored at -20°C until assayed.
T6087 8001-8115 Sentence denotes To each well was added FK506, rapamycin, curcumin, PDTC, LY294002, SB203580, PD98059, dexamethasone or wortmannin.
T6086 7868-8000 Sentence denotes Subsequently, various concentrations of cyclosporin A (10–500 ng/ml) were added to the medium and cells were incubated for 24 hours.
T6085 7727-7867 Sentence denotes Cell suspension (1 ml) was dispensed into 24-well multi-well plates (Nunc, Roskilde, Denmark), and incubated for 24 hours at 37°C in 5% CO2.
T6084 7527-7726 Sentence denotes In brief, the cell suspensions were adjusted to a concentration of 106/ml in RPMI 1640 medium supplemented with 10% fetal calf serum, 100 U/ml penicillin, 100 mg/ml streptomycin and 2 mM L-glutamine.
T6083 7468-7526 Sentence denotes Cell cultures were performed as described previously [18].
T6082 7366-7467 Sentence denotes PBMC were prepared from heparinized blood by Ficoll-Hypaque (SG1077) density-gradient centrifugation.
T6081 7291-7365 Sentence denotes Production of IL-17 by T cell receptor activation, cytokines or chemokines
T5355 7187-7289 Sentence denotes LY294002, SB203580, FK506, wortmannin and PD98059 were obtained from Calbiochem (Schwalbach, Germany).
T5354 7068-7186 Sentence denotes Anti-CD3 monoclonal antibody and anti-CD28 monoclonal antibody were obtained from BD Biosciences (San Diego, CA, USA).
T5353 6901-7067 Sentence denotes Phytohemagglutinin (PHA), pyrrolidine dithiocarbamate (PDTC), rapamycin, dexamethasone and curcumin were all obtained from the Sigma Chemical Co. (St Louis, MA, USA).
T5352 6837-6900 Sentence denotes Cyclosporin A was provided by Sandos Ltd. (Basel, Switzerland).
T5351 6755-6836 Sentence denotes Recombinant TNF-α and IL-1 were purchased from Endogen Inc. (Cambridge, MA, USA).
T5350 6665-6754 Sentence denotes Recombinant transforming growth factor (TGF)-β was purchased from Peprotech (London, UK).
T5349 6466-6664 Sentence denotes Recombinant IL-17, IL-18, IL-15, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β, IL-6 and IL-8 were purchased from R & D systems (Minneapolis, MN, USA).
T542 2237-2405 Sentence denotes These results suggest that signal transduction pathways dependent on PI3K/Akt and NF-κB are involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T541 2115-2236 Sentence denotes However, inhibition of activator protein-1 and extracellular signal-regulated kinase 1/2 did not affect IL-17 production.
T540 1912-2114 Sentence denotes IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-κB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively.
T539 1746-1911 Sentence denotes Anti-CD3 antibody activated the PI3K/Akt pathway; activation of this pathway resulted in a pronounced augmentation of nuclear factor κB (NF-κB) DNA-binding activity.
T538 1610-1745 Sentence denotes IL-17 was also detected in the PBMC of patients with osteoarthritis, but their expression levels were much lower than those of RA PBMC.
T537 1392-1609 Sentence denotes Among tested cytokines and chemokines, IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production (P < 0.05), whereas tumor necrosis factor-α, IL-1β, IL-18 or transforming growth factor-β did not.
T536 1254-1391 Sentence denotes The production of IL-17 was significantly increased in cells treated with anti-CD3 antibody with or without anti-CD28 and PHA (P < 0.05).
T535 1126-1253 Sentence denotes IL-17 levels were determined by sandwich enzyme-linked immunosorbent assay and reverse transcription–polymerase chain reaction.
T534 894-1125 Sentence denotes Peripheral blood mononuclear cells (PBMC) from patients with RA (n = 24) were separated, then stimulated with various agents including anti-CD3, anti-CD28, phytohemagglutinin (PHA) and several inflammatory cytokines and chemokines.
T533 750-893 Sentence denotes In the present study, we investigated the role of the phosphoinositide 3-kinase (PI3K)/Akt pathway in the regulation of IL-17 production in RA.
T532 575-749 Sentence denotes Although some cytokines (IL-15 and IL-23) have been reported to regulate IL-17 production, the intracellular signaling pathways that regulate IL-17 production remain unknown.
T531 444-574 Sentence denotes Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA.
T530 273-443 Sentence denotes Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption.
T529 160-272 Sentence denotes Inflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA).
T5348 6457-6465 Sentence denotes Reagents
T4878 6326-6455 Sentence denotes Informed consent was obtained, and the protocol was approved by the Catholic University of Korea Human Research Ethics Committee.
T4877 6187-6325 Sentence denotes The mean ages of the patients with OA and the healthy controls were 50 ± 8 years (range 34–68 years) and 30 ± 6 years (range 24–57 years).
T4876 6038-6186 Sentence denotes Comparisons were made with 14 patients with OA (3 men and 11 women) and with 14 healthy controls (3 men and 11 women) who had no rheumatic diseases.
T4875 5973-6037 Sentence denotes All medications were stopped 48 hours before entry to the study.
T4874 5890-5972 Sentence denotes The age of the patients with RA was 50 ± 8 (mean ± SEM) years (range 23–71 years).
T4873 5681-5889 Sentence denotes Informed consent was obtained from 24 patients (5 men and 19 women) with RA who fulfilled the 1987 revised criteria of the American College of Rheumatology (formerly the American Rheumatism Association) [17].
T4872 5672-5680 Sentence denotes Patients
T2751 2922-3112 Sentence denotes A little over a decade ago, the primacy of T cells in the pathogenesis of autoimmune disease such as RA was undisputed because they are the largest cell population infiltrating the synovium.
T2750 2667-2921 Sentence denotes The favorable clinical benefits obtained with inhibitors of tumor necrosis factor (TNF)-α) and interleukin (IL)-1 suggest that the blockade of key inflammatory cytokines has been the important issue in the development of new therapeutic applications [2].
T2749 2549-2666 Sentence denotes Proinflammatory cytokines released from these cells are known to be important in the destruction of joints in RA [1].
T2748 2420-2548 Sentence denotes Rheumatoid arthritis (RA) is characterized by infiltrations of macrophages and T cells into the joint, and synovial hyperplasia.
T2765 5519-5647 Sentence denotes These results might provide new insights into the pathogenesis of RA and future directions for new therapeutic strategies in RA.
T2764 5326-5518 Sentence denotes We found that the intracellular signaling pathway involving phosphoinositide 3-kinase (PI3K)/Akt and NF-κB might be involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T2763 5181-5325 Sentence denotes In the present study we used various stimuli to investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway.
T2762 4981-5180 Sentence denotes Although the contribution of IL-17 in joint inflammation in RA has been documented in earlier studies [12,15,16], the intracellular signal transduction pathway for IL-17 production remains uncertain.
T2761 4838-4980 Sentence denotes Recently, Happel and colleagues also showed that IL-23 could be an efficient trigger of IL-17 production from both CD4+ and CD8+ T cells [14].
T2760 4628-4837 Sentence denotes IL-15, secreted from activated macrophages, has been reported to be an important trigger of IL-17 production in RA peripheral blood mononuclear cells (PBMC) by cyclosporine and steroid sensitive pathways [13].
T2759 4443-4627 Sentence denotes Levels of IL-17 in synovial fluids were significantly higher in patients with RA than in patients with osteoarthritis (OA), and it was produced by CD4+ T cells in the synovium [11,12].
T2758 4217-4442 Sentence denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes, and has the ability to differentiate and activate the dendritic cells [8-10].
T2757 3997-4216 Sentence denotes Recent observations demonstrated that IL-17 can also activate osteoclastic bone resorption by the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand), which is involved in bony erosion in RA [7].
T2756 3832-3996 Sentence denotes This cytokine is of interest for two major reasons: first, similarly to TNF-α and IL-1, IL-17 has proinflammatory properties; second, it is produced by T cells [6].
T2755 3700-3831 Sentence denotes IL-17 is one of the inflammatory cytokines secreted mainly by activated T cells, which can induce IL-6 and IL-8 by fibroblasts [5].
T2754 3448-3699 Sentence denotes Because we have already demonstrated the enhanced proliferation of antigen specific T cells, especially to type II collagen, and the skewing of T helper type 1 (Th1) cytokines in RA [4], the role of T cells needs to be elucidated in different aspects.
T2753 3369-3447 Sentence denotes This paradox has questioned the role of T cells in the pathogenesis of RA [3].
T2752 3113-3368 Sentence denotes However, a series of studies demonstrated paucity of T cell-derived cytokines such as IL-2 and interferon-γ in the joints of RA, whereas macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α were abundant in rheumatoid synovium.
T1 0-149 Sentence denotes Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis
T2 151-159 Sentence denotes Abstract
T3 160-272 Sentence denotes Inflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA).
T4 273-443 Sentence denotes Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption.
T5 444-574 Sentence denotes Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA.
T6 575-749 Sentence denotes Although some cytokines (IL-15 and IL-23) have been reported to regulate IL-17 production, the intracellular signaling pathways that regulate IL-17 production remain unknown.
T7 750-893 Sentence denotes In the present study, we investigated the role of the phosphoinositide 3-kinase (PI3K)/Akt pathway in the regulation of IL-17 production in RA.
T8 894-1125 Sentence denotes Peripheral blood mononuclear cells (PBMC) from patients with RA (n = 24) were separated, then stimulated with various agents including anti-CD3, anti-CD28, phytohemagglutinin (PHA) and several inflammatory cytokines and chemokines.
T9 1126-1253 Sentence denotes IL-17 levels were determined by sandwich enzyme-linked immunosorbent assay and reverse transcription–polymerase chain reaction.
T10 1254-1391 Sentence denotes The production of IL-17 was significantly increased in cells treated with anti-CD3 antibody with or without anti-CD28 and PHA (P < 0.05).
T11 1392-1609 Sentence denotes Among tested cytokines and chemokines, IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production (P < 0.05), whereas tumor necrosis factor-α, IL-1β, IL-18 or transforming growth factor-β did not.
T12 1610-1745 Sentence denotes IL-17 was also detected in the PBMC of patients with osteoarthritis, but their expression levels were much lower than those of RA PBMC.
T13 1746-1911 Sentence denotes Anti-CD3 antibody activated the PI3K/Akt pathway; activation of this pathway resulted in a pronounced augmentation of nuclear factor κB (NF-κB) DNA-binding activity.
T14 1912-2114 Sentence denotes IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-κB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively.
T15 2115-2236 Sentence denotes However, inhibition of activator protein-1 and extracellular signal-regulated kinase 1/2 did not affect IL-17 production.
T16 2237-2405 Sentence denotes These results suggest that signal transduction pathways dependent on PI3K/Akt and NF-κB are involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T17 2407-2419 Sentence denotes Introduction
T18 2420-2548 Sentence denotes Rheumatoid arthritis (RA) is characterized by infiltrations of macrophages and T cells into the joint, and synovial hyperplasia.
T19 2549-2666 Sentence denotes Proinflammatory cytokines released from these cells are known to be important in the destruction of joints in RA [1].
T20 2667-2921 Sentence denotes The favorable clinical benefits obtained with inhibitors of tumor necrosis factor (TNF)-α) and interleukin (IL)-1 suggest that the blockade of key inflammatory cytokines has been the important issue in the development of new therapeutic applications [2].
T21 2922-3112 Sentence denotes A little over a decade ago, the primacy of T cells in the pathogenesis of autoimmune disease such as RA was undisputed because they are the largest cell population infiltrating the synovium.
T22 3113-3368 Sentence denotes However, a series of studies demonstrated paucity of T cell-derived cytokines such as IL-2 and interferon-γ in the joints of RA, whereas macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α were abundant in rheumatoid synovium.
T23 3369-3447 Sentence denotes This paradox has questioned the role of T cells in the pathogenesis of RA [3].
T24 3448-3699 Sentence denotes Because we have already demonstrated the enhanced proliferation of antigen specific T cells, especially to type II collagen, and the skewing of T helper type 1 (Th1) cytokines in RA [4], the role of T cells needs to be elucidated in different aspects.
T25 3700-3831 Sentence denotes IL-17 is one of the inflammatory cytokines secreted mainly by activated T cells, which can induce IL-6 and IL-8 by fibroblasts [5].
T26 3832-3996 Sentence denotes This cytokine is of interest for two major reasons: first, similarly to TNF-α and IL-1, IL-17 has proinflammatory properties; second, it is produced by T cells [6].
T27 3997-4216 Sentence denotes Recent observations demonstrated that IL-17 can also activate osteoclastic bone resorption by the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand), which is involved in bony erosion in RA [7].
T28 4217-4442 Sentence denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes, and has the ability to differentiate and activate the dendritic cells [8-10].
T29 4443-4627 Sentence denotes Levels of IL-17 in synovial fluids were significantly higher in patients with RA than in patients with osteoarthritis (OA), and it was produced by CD4+ T cells in the synovium [11,12].
T30 4628-4837 Sentence denotes IL-15, secreted from activated macrophages, has been reported to be an important trigger of IL-17 production in RA peripheral blood mononuclear cells (PBMC) by cyclosporine and steroid sensitive pathways [13].
T31 4838-4980 Sentence denotes Recently, Happel and colleagues also showed that IL-23 could be an efficient trigger of IL-17 production from both CD4+ and CD8+ T cells [14].
T32 4981-5180 Sentence denotes Although the contribution of IL-17 in joint inflammation in RA has been documented in earlier studies [12,15,16], the intracellular signal transduction pathway for IL-17 production remains uncertain.
T33 5181-5325 Sentence denotes In the present study we used various stimuli to investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway.
T34 5326-5518 Sentence denotes We found that the intracellular signaling pathway involving phosphoinositide 3-kinase (PI3K)/Akt and NF-κB might be involved in the overproduction of the key inflammatory cytokine IL-17 in RA.
T35 5519-5647 Sentence denotes These results might provide new insights into the pathogenesis of RA and future directions for new therapeutic strategies in RA.
T36 5649-5670 Sentence denotes Materials and methods
T37 5672-5680 Sentence denotes Patients
T38 5681-5889 Sentence denotes Informed consent was obtained from 24 patients (5 men and 19 women) with RA who fulfilled the 1987 revised criteria of the American College of Rheumatology (formerly the American Rheumatism Association) [17].
T39 5890-5972 Sentence denotes The age of the patients with RA was 50 ± 8 (mean ± SEM) years (range 23–71 years).
T40 5973-6037 Sentence denotes All medications were stopped 48 hours before entry to the study.
T41 6038-6186 Sentence denotes Comparisons were made with 14 patients with OA (3 men and 11 women) and with 14 healthy controls (3 men and 11 women) who had no rheumatic diseases.
T42 6187-6325 Sentence denotes The mean ages of the patients with OA and the healthy controls were 50 ± 8 years (range 34–68 years) and 30 ± 6 years (range 24–57 years).
T43 6326-6455 Sentence denotes Informed consent was obtained, and the protocol was approved by the Catholic University of Korea Human Research Ethics Committee.
T44 6457-6465 Sentence denotes Reagents
T45 6466-6664 Sentence denotes Recombinant IL-17, IL-18, IL-15, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β, IL-6 and IL-8 were purchased from R & D systems (Minneapolis, MN, USA).
T46 6665-6754 Sentence denotes Recombinant transforming growth factor (TGF)-β was purchased from Peprotech (London, UK).
T47 6755-6836 Sentence denotes Recombinant TNF-α and IL-1 were purchased from Endogen Inc. (Cambridge, MA, USA).
T48 6837-6900 Sentence denotes Cyclosporin A was provided by Sandos Ltd. (Basel, Switzerland).
T49 6901-7067 Sentence denotes Phytohemagglutinin (PHA), pyrrolidine dithiocarbamate (PDTC), rapamycin, dexamethasone and curcumin were all obtained from the Sigma Chemical Co. (St Louis, MA, USA).
T50 7068-7186 Sentence denotes Anti-CD3 monoclonal antibody and anti-CD28 monoclonal antibody were obtained from BD Biosciences (San Diego, CA, USA).
T51 7187-7289 Sentence denotes LY294002, SB203580, FK506, wortmannin and PD98059 were obtained from Calbiochem (Schwalbach, Germany).
T52 7291-7365 Sentence denotes Production of IL-17 by T cell receptor activation, cytokines or chemokines
T53 7366-7467 Sentence denotes PBMC were prepared from heparinized blood by Ficoll-Hypaque (SG1077) density-gradient centrifugation.
T54 7468-7526 Sentence denotes Cell cultures were performed as described previously [18].
T55 7527-7726 Sentence denotes In brief, the cell suspensions were adjusted to a concentration of 106/ml in RPMI 1640 medium supplemented with 10% fetal calf serum, 100 U/ml penicillin, 100 mg/ml streptomycin and 2 mM L-glutamine.
T56 7727-7867 Sentence denotes Cell suspension (1 ml) was dispensed into 24-well multi-well plates (Nunc, Roskilde, Denmark), and incubated for 24 hours at 37°C in 5% CO2.
T57 7868-8000 Sentence denotes Subsequently, various concentrations of cyclosporin A (10–500 ng/ml) were added to the medium and cells were incubated for 24 hours.
T58 8001-8115 Sentence denotes To each well was added FK506, rapamycin, curcumin, PDTC, LY294002, SB203580, PD98059, dexamethasone or wortmannin.
T59 8116-8238 Sentence denotes After incubation for 24 hours (unless otherwise stated), cell-free media were collected and stored at -20°C until assayed.
T60 8239-8320 Sentence denotes All cultures were set up in triplicate, and results are expressed as means ± SEM.
T61 8322-8351 Sentence denotes CD4+ T-cell isolation by MACS
T62 8352-8445 Sentence denotes Anti-CD4 microbeads were used essentially as recommended by the manufacturer (Miltenyi) [19].
T63 8446-8500 Sentence denotes PBMC were resuspended in 80 μl of FBS staining buffer.
T64 8501-8575 Sentence denotes Anti-CD4 microbeads (20 μl) were added and incubated for 15 min at 6–12°C.
T65 8576-8665 Sentence denotes Saturating amounts of fluorochrome-conjugated antibodies were added for a further 10 min.
T66 8666-8838 Sentence denotes Cells were diluted in 2.5 ml of FBS staining buffer, pelleted, resuspended in 500 μl and magnetically separated, usually on an AutoMACS magnet fitted with a MACS MS column.
T67 8839-8912 Sentence denotes Flow-through and two 1 ml washes were collected as the negative fraction.
T68 8913-9012 Sentence denotes Enriched cells were collected in two 0.5 ml aliquots from the column after removal from the magnet.
T69 9013-9244 Sentence denotes Alternatively, cells stained with anti-CD4–phycoerythrin were washed, magnetically labeled with anti-phycoerythrin microbeads (20 μl added to 80 μl of cell suspension; 15 min, 6–12°C), and magnetically separated as described above.
T70 9245-9348 Sentence denotes The purity of cells was assessed by flow cytometric analysis of stained cells on a FACS Vantage sorter.
T71 9349-9418 Sentence denotes Most (more than 97%) of the isolated cells had the CD4 T cell marker.
T72 9420-9462 Sentence denotes Enzyme-linked immunosorbent assay of IL-17
T73 9463-9581 Sentence denotes IL-17 in culture supernatants was measured by sandwich enzyme-linked immunosorbent assay as described previously [20].
T74 9582-9708 Sentence denotes In brief, a 96-well plate (Nunc) was coated with 4 μg/ml monoclonal antibodies against IL-17 (R & D Systems) at 4°C overnight.
T75 9709-9985 Sentence denotes After blocking with phosphate-buffered saline/1% bovine serum albumin (BSA)/0.05% Tween 20 for 2 hours at room temperature (22–25°C), test samples and the standard recombinant IL-17 (R & D Systems) were added to the 96-well plate and incubated at room temperature for 2 hours.
T76 9986-10194 Sentence denotes Plates were washed four times with phosphate-buffered saline/Tween 20, and then incubated with 500 ng/ml biotinylated mouse monoclonal antibodies against IL-17 (R & D Systems) for 2 hours at room temperature.
T77 10195-10453 Sentence denotes After washing, streptavidin–alkaline phosphate–horseradish peroxidase conjugate (Sigma) was incubated for 2 hours, then washed again and incubated with 1 mg/ml p-nitrophenyl phosphate (Sigma) dissolved in diethanolamine (Sigma) to develop the color reaction.
T78 10454-10563 Sentence denotes The reaction was stopped by the addition of 1 M NaOH and the optical density of each well was read at 405 nm.
T79 10564-10612 Sentence denotes The lower limit of IL-17 detection was 10 pg/ml.
T80 10613-10729 Sentence denotes Recombinant human IL-17 diluted in culture medium was used as a calibration standard, ranging from 10 to 2000 pg/ml.
T81 10730-10900 Sentence denotes A standard curve was drawn by plotting optical density against the log of the concentration of recombinant cytokines, and used for determination of IL-17 in test samples.
T82 10902-10998 Sentence denotes Quantification of IL-17 mRNA by semiquantitative reverse transcription–polymerase chain reaction
T83 10999-11117 Sentence denotes PBMC were incubated with various concentrations of anti-CD3 in the presence or absence of inhibitors (LY294002, PDTC).
T84 11118-11272 Sentence denotes After 16 hours of incubation, mRNA was extracted with RNAzol B (Biotex Laboratories, Houston, TX, USA) in accordance with the manufacturer's instructions.
T85 11273-11414 Sentence denotes Reverse transcription of 2 μg of total mRNA was performed at 42°C using the Superscript™ reverse transcription system (Takara, Shiga, Japan).
T86 11415-11568 Sentence denotes PCR amplification of cDNA aliquots was performed by adding 2.5 mM dNTPs, 2.5 U of Taq DNA polymerase (Takara) and 0.25 μM of sense and antisense primers.
T87 11569-11687 Sentence denotes The reaction was performed in PCR buffer (1.5 mM MgCl2, 50 mM KCl, 10 mM Tris-HCl, pH 8.3) in a total volume of 25 μl.
T88 11688-12007 Sentence denotes The following sense and antisense primers for each molecules were used: IL-17 sense, 5'-ATG ACT CCT GGG AAG ACC TCA TTG-3'; IL-17 antisense, 5'-TTA GGC CAC ATG GTG GAC AAT CGG-3'; glyceraldehyde-3-phosphate dehydrogenase (GAPDH) sense, 5'-CGA TGC TGG GCG TGA GTA C-3'; GAPDH antisense, 5'-CGT TCA GCT CAG GGA TGA CC-3'.
T89 12008-12233 Sentence denotes Reactions were processed in a DNA thermal cycler (Perkin-Elmer Cetus, Norwalk, CT, USA) through cycles for 30 s of denaturation at 94°C, 1 min of annealing at 56°C for GAPDH and IL-17, followed by 1 min of elongation at 72°C.
T90 12234-12399 Sentence denotes PCR rounds were repeated for 25 cycles each for both GAPDH and IL-17; this was determined as falling within the exponential phase of amplification for each molecule.
T91 12400-12494 Sentence denotes The level of mRNA expression was presented as a ratio of IL-17 PCR product over GAPDH product.
T92 12496-12554 Sentence denotes Western blot analysis of Akt, phosphorylated Akt and IκB-α
T93 12555-12647 Sentence denotes PBMC were incubated with anti-CD3 (10 μg/ml) in the presence or absence of LY294002 (20 μM).
T94 12648-12825 Sentence denotes After incubation for 1 hour, whole cell lysates were prepared from about 107 cells by homogenization in the lysis buffer, and centrifuged at 14,000 r.p.m. (19,000 g) for 15 min.
T95 12826-12939 Sentence denotes Protein concentrations in the supernatants were determined with the Bradford method (Bio-Rad, Hercules, CA, USA).
T96 12940-13078 Sentence denotes Protein samples were separated by 10% SDS–PAGE and transferred to a nitrocellulose membrane (Amersham Pharmacia Biotech, Uppsala, Sweden).
T97 13079-13436 Sentence denotes For western hybridization, membrane was preincubated with 0.1% skimmed milk in TBS-T buffer (0.1% Tween 20 in Tris-buffered saline) at room temperature for 2 hours, then primary antibodies against Akt, phosphorylated Akt and IκB-α (Cell Signaling Technology Inc., Beverly, MA, USA), diluted 1:1000 in 5% BSA/TBS-T, were added and incubated overnight at 4°C.
T98 13437-13595 Sentence denotes After washing four times with TBS-T, horseradish peroxidase-conjugated secondary antibodies were added and allowed to incubate for 1 hour at room temperature.
T99 13596-13752 Sentence denotes After TBS-T washing, hybridized bands were detected with the enhanced chemiluminescence (ECL) detection kit and Hyperfilm-ECL reagents (Amersham Pharmacia).
T100 13754-13800 Sentence denotes Gel mobility-shift assay of NF-κB binding site
T101 13801-13857 Sentence denotes Nuclear proteins were extracted from about 5 × 106 PBMC.
T102 13858-14115 Sentence denotes Oligonucleotide probes encompassing the NF-κB binding site of the human IL-17 promoter (5'-ATG ACC TGG AAA TAC CCA AAA TTC-3') were generated by 5'-end labeling of the sense strand with [γ-32P]dATP (Amersham Pharmacia) and T4 polynucleotide kinase (TaKaRa).
T103 14116-14226 Sentence denotes Unincorporated nucleotides were removed by NucTrap probe purification columns (Stratagene, La Jolla, CA, USA).
T104 14227-14539 Sentence denotes Nuclear extracts (2 μg of protein) were incubated with radiolabeled DNA probes (10 ng; 100,000 c.p.m.) for 30 min at room temperature in 20 μl of binding buffer consisting of 20 mM Tris-HCl, pH 7.9, 50 mM KCl, 1 mM dithiothreitol, 0.5 mM EDTA, 5% glycerol, 1 mg/ml BSA, 0.2% Nonidet P40 and 50 ng/μl poly(dI-dC).
T105 14540-14673 Sentence denotes Samples were subjected to electrophoresis on nondenaturing 5% polyacrylamide gels in 0.5 × Tris-borate-EDTA buffer (pH 8.0) at 100 V.
T106 14674-14771 Sentence denotes Gels were dried under vacuum and exposed to Kodak X-OMAT film at -70°C with intensifying screens.
T107 14772-14900 Sentence denotes Rabbit polyclonal antibodies against NF-κB subunits p50, p65 and c-Rel were from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
T108 14902-14950 Sentence denotes Cell viability (Trypan blue dye exclusion assay)
T109 14951-15100 Sentence denotes For cell viability assays, the trypan blue dye exclusion method was used to evaluate the potential of direct cytotoxic effect of inhibitors on cells.
T110 15101-15296 Sentence denotes After incubation for 24 hours, the cells were harvested and the percentage cell viability was calculated with the formula 100 × (number of viable cells/number of both viable and dead cells) [21].
T111 15298-15318 Sentence denotes Statistical analysis
T112 15319-15353 Sentence denotes Data are expressed as means ± SEM.
T113 15354-15429 Sentence denotes Statistical analysis was performed with Student's t-test for matched pairs.
T114 15430-15482 Sentence denotes P values less than 0.05 were considered significant.
T115 15484-15491 Sentence denotes Results
T116 15493-15580 Sentence denotes IL-17 production in PBMC from patients with RA, patients with OA and normal individuals
T117 15581-15778 Sentence denotes PBMC were separated and cultured with PHA (5 μg/ml) from patients with RA, patients with OA, and age-matched normal controls; IL-17 levels were then determined in the culture supernatants (Fig. 1).
T118 15779-16118 Sentence denotes Although the amounts of basal IL-17 secretion were not different between RA, OA and normal controls (62 ± 31, 43 ± 19 and 43 ± 10 pg/ml, respectively), the IL-17 production stimulated by PHA was significantly higher in RA PBMC than in those from OA and controls (768 ± 295 versus 463 ± 211 pg/ml [P < 0.05] and 241 ± 29 pg/ml [P < 0.001]).
T119 16120-16212 Sentence denotes Increased IL-17 production in PBMC of patients with RA by anti-CD3 and/or anti-CD28, and PHA
T120 16213-16493 Sentence denotes Because IL-17 was already known from earlier reports to be produced mainly by activated T cells, we investigated the effect of different concentrations of anti-CD3 (1, 5 and 10 μg/ml) as a T cell activation, which showed a dose-dependent increase in IL-17 levels (data not shown).
T121 16494-16578 Sentence denotes On the basis of this, we chose 10 μg/ml as a stimulation concentration for anti-CD3.
T122 16579-16783 Sentence denotes As shown in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold, and the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold) than anti-CD3 alone.
T123 16784-16968 Sentence denotes Furthermore, when incubated with T cell mitogens such as PHA, increased IL-17 production was more pronounced than with anti-CD3 and anti-CD28 (588 ± 85 versus 211 ± 1 pg/ml; P < 0.05).
T124 16970-17052 Sentence denotes Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
T125 17053-17253 Sentence denotes Because RA PBMC include several cell types in addition to T cells, some inflammatory cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells.
T126 17254-17410 Sentence denotes To evaluate the effects of inflammatory cytokines released by activated PBMC, we tested the effects of several cytokines and chemokines on IL-17 production.
T127 17411-17622 Sentence denotes We detected an increase in IL-17 level after stimulation with IL-15 (10 ng/ml), whereas with IL-1β (10 ng/ml), TNF-α (10 ng/ml), IL-18 (10 ng/ml) or TGF-β (10 ng/ml) the levels in IL-17 were unchanged (Fig. 2a).
T128 17623-17901 Sentence denotes When treated with MCP-1 (10 ng/ml) or IL-6 (10 ng/ml), significant upregulations of IL-17 proteins were observed (62 ± 42 and 50 ± 10 versus 31 ± 11 pg/ml, respectively; P < 0.05), whereas none was observed with IL-8 (10 ng/ml), MIP-1α (10 ng/ml) or MIP-1β (10 ng/ml) (Fig. 2b).
T129 17903-17992 Sentence denotes Inhibition of IL-17 production by signal transduction inhibitors and anti-rheumatic drugs
T130 17993-18126 Sentence denotes Having observed the increased IL-17 production in RA PBMC, it was important to know which signal transduction pathways were involved.
T131 18127-18390 Sentence denotes As illustrated in Fig. 3, an significant decrease in anti-CD3-induced IL-17 production was observed when co-incubated with NF-κB inhibitor, PDTC and dexamethasone in comparison with anti-CD3 alone (38 ± 5 and 54 ± 11 versus 98 ± 19 pg/ml, respectively; P < 0.05).
T132 18391-18599 Sentence denotes LY294002 and wortmannin, as an inhibitor of PI3K, also markedly inhibited the anti-CD3-induced IL-17 production in RA PBMC (98 ± 19 versus 38 ± 10 pg/ml [P < 0.005] and 48 ± 4 pg/ml [P < 0.05], respectively).
T133 18600-18842 Sentence denotes The calcineurin inhibitors cyclosporin A and FK506 also downregulated the IL-17 secretion as well as the mitogen-activated protein kinase (MAPK) p38 inhibitor SB203580 did, whereas rapamycin and PD98059 had no effect on IL-17 levels (Fig. 3).
T134 18843-19032 Sentence denotes To evaluate the possibility of non-specific inhibition by the drug at high concentrations, we observed the dose response of PDTC and LY294002 for the inhibition of IL-17 production in PBMC.
T135 19033-19126 Sentence denotes There were dose-dependent inhibitions of IL-17 production with chemical inhibitors (Fig. 4a).
T136 19127-19219 Sentence denotes The other inhibitors in addition to PDTC and LY294002 showed the same pattern of inhibition.
T137 19220-19332 Sentence denotes Cytotoxic effects on PBMC by the chemical inhibitors at experimental concentrations were not observed (Fig. 4b).
T138 19334-19366 Sentence denotes IL-17 mRNA expression in RA PBMC
T139 19367-19535 Sentence denotes To see whether enhanced IL-17 production could be regulated at a transcriptional level, semi-quantatitive reverse transcription–polymerase chain reaction was performed.
T140 19536-19724 Sentence denotes We observed a dose-dependent increase in IL-17 mRNA transcripts after stimulation with anti-CD3; this was inhibited by the PI3K inhibitor LY294002 and by the NF-κB inhibitor PDTC (Fig. 5).
T141 19726-19808 Sentence denotes Activation of PI3K/Akt signal transduction pathway on IL-17 production by anti-CD3
T142 19809-19928 Sentence denotes To determine downstream effector molecules of the PI3K pathway, we evaluated the activation of Akt by western blotting.
T143 19929-20083 Sentence denotes As shown in Fig. 6, at 10 min of incubation with anti-CD3 (10 μg/ml) or LY294002 (20 μM), no difference in the amounts of phosphorylated Akt was observed.
T144 20084-20259 Sentence denotes However, after 30 min of incubation, phosphorylated Akt increased (lane 2), and the effect of inhibition by LY294002 (lane 3) reached a peak at 60 min, lasting to 120–240 min.
T145 20260-20357 Sentence denotes In contrast, non-phosphorylated Akt and β-actin remained unchanged regardless of incubation time.
T146 20358-20555 Sentence denotes PHA, concanavalin A and IL-15 also demonstrated the same effect on phosphorylated Akt as shown with anti-CD3, which was an inhibition by wortmannin and PDTC as well as by LY294002 (data not shown).
T147 20557-20648 Sentence denotes Activation of the NF-κB and activator protein-1 (AP-1) pathway in the IL-17 promoter region
T148 20649-20937 Sentence denotes To investigate further the intracellular signaling pathway activated by anti-CD3 plus anti-CD28, concanavalin A, PHA and IL-15, and responsible for inducing IL-17 expression, we performed an electrophoretic mobility-shift assay (EMSA) of NF-κB recognition sites in the promoters of IL-17.
T149 20938-21142 Sentence denotes As shown in Fig. 7a, nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters in comparison with that of controls (lane 1).
T150 21143-21242 Sentence denotes A supershift assay demonstrated shifted bands in p65 and p50 (lanes 3 and 4) not in c-Rel (lane 5).
T151 21243-21399 Sentence denotes In normal PBMC the same pattern was observed, but the degree of NF-κB activation by anti-CD3 plus anti-CD28 was less intense than that in RA PBMC (Fig. 7b).
T152 21400-21555 Sentence denotes To confirm the link between PI3K activity and NF-κB, we performed EMSA to determine the NF-κB binding activity after treatment with both LY294002 and PDTC.
T153 21556-21633 Sentence denotes Both agents block NF-κB DNA-binding activity in the IL-17 promoter (Fig. 7c).
T154 21634-21751 Sentence denotes Western blotting for IκB-α showed inhibition of degradation of IκB-α by LY294002 and PDTC at the same time (Fig. 7c).
T155 21752-21991 Sentence denotes In contrast, the AP-1 pathway was not activated by stimulation with anti-CD3 plus anti-CD28 (data not shown), demonstrating that NF-κB is the main intracellular signaling pathway in IL-17 production by activated PBMC from patients with RA.
T156 21993-22003 Sentence denotes Discussion
T157 22004-22089 Sentence denotes IL-17 was first described as a T cell product with proinflammatory properties [5,22].
T158 22090-22204 Sentence denotes RA is characterized by hyperplasia of synovial lining cells and an intense infiltration by mononuclear cells [23].
T159 22205-22421 Sentence denotes Proinflammatory cytokines such as IL-1 and TNF-α are abundant in rheumatoid synovium, whereas the T cell-derived cytokines, especially IL-4 and interferon-γ, have often proved difficult to detect in RA synovium [24].
T160 22422-22576 Sentence denotes Although T cells may have a role in the augmentation of rheumatoid synovial inflammation, the lack of T cell-derived cytokines has limited its importance.
T161 22577-22704 Sentence denotes In this respect, IL-17 is appealing because it has been described as a T cell-derived cytokine with proinflammatory properties.
T162 22705-22824 Sentence denotes In our studies, we tried to evaluate how IL-17 production is regulated in RA PBMC, and which signaling pathway it used.
T163 22825-22917 Sentence denotes Levels of IL-17 were found to be higher in RA synovial fluid than in OA synovial fluid [15].
T164 22918-23134 Sentence denotes However, there are few data available on the agents that stimulate IL-17 production in RA, although the highest level of IL-17 production can be achieved by anti-CD3/anti-CD28 stimulation in healthy individuals [25].
T165 23135-23312 Sentence denotes In our experiments, PHA as mitogens, as well as anti-CD3/anti-CD28 for signaling through the T cell receptor, increased IL-17 production from RA PBMC in a dose-dependent manner.
T166 23313-23485 Sentence denotes We found, by a cell proliferation assay (data not shown), that this upregulation of IL-17 might be due to increased cellular activity rather than to cellular proliferation.
T167 23486-23595 Sentence denotes IL-17 is produced mainly by activated CD4+ T cells, especially for Th1/Th0 cells, not the Th2 phenotype [26].
T168 23596-23721 Sentence denotes However, it can also be produced by CD8+ T cells via an IL-23 triggering mechanism in Gram-negative pulmonary infection [14].
T169 23722-23863 Sentence denotes In addition, IL-17 production was significantly augmented by T cells recognizing type II collagen in a collagen-induced arthritis model [27].
T170 23864-24037 Sentence denotes A complex interaction between cells in inflamed RA joints might produce a variety of proinflammatory cytokines and chemokines, which also activate other cells in the joints.
T171 24038-24232 Sentence denotes For example, IL-17 stimulates rheumatoid synoviocytes to secrete several cytokines such as IL-6, IL-8 and tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,28,29].
T172 24233-24417 Sentence denotes There are as yet few data available on the agents that stimulate IL-17 production in RA, although some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14].
T173 24418-24616 Sentence denotes We therefore investigated the in vitro production of IL-17 in RA PBMC responding to a variety of cytokines/chemokines and mitogens as well as T cell receptor (TCR) ligation using anti-CD3/anti-CD28.
T174 24617-24746 Sentence denotes Our studies demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC.
T175 24747-24826 Sentence denotes Adding IL-15 or MCP-1 to TCR ligation augmented IL-17 production more markedly.
T176 24827-24973 Sentence denotes In contrast, IL-1 and TNF-α, which are known to have proinflammatory properties and to be increased in RA joints, did not affect IL-17 production.
T177 24974-25105 Sentence denotes Our data were consistent with a recent report that IL-15 triggered in vitro IL-17 production in PBMC, but TNF-α did not do so [13].
T178 25106-25291 Sentence denotes Although there were no data that MCP-1 directly induces T cell activation, it might exert effects indirectly on T cells through the activation of monocytes/macrophages in PBMC cultures.
T179 25292-25420 Sentence denotes As reported for normal individuals [25], T cell activation through anti-CD3/anti-CD28 also increases IL-17 induction in RA PBMC.
T180 25421-25640 Sentence denotes Although the signaling pathway for the induction of cytokines/chemokines by IL-17 has been documented widely [8,30,31], no data have been available on how IL-17 production can be regulated by certain signaling pathways.
T181 25641-25785 Sentence denotes By using signal transduction inhibitors, we therefore examined which signaling pathway was mainly involved in the induction of IL-17 in RA PBMC.
T182 25786-25998 Sentence denotes We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation.
T183 25999-26120 Sentence denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor.
T184 26121-26206 Sentence denotes It is interesting that a series of evidence supports crosstalk between NF-κB and p38.
T185 26207-26375 Sentence denotes In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33].
T186 26376-26592 Sentence denotes Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation.
T187 26593-26702 Sentence denotes The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments.
T188 26703-26851 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T189 26852-26988 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T190 26989-27204 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T191 27205-27372 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T192 27373-27562 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T193 27563-27838 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T194 27839-28087 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.
T195 28089-28100 Sentence denotes Conclusions
T196 28101-28245 Sentence denotes We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation by anti-CD3/anti-CD28.
T197 28246-28424 Sentence denotes We have also shown that upregulation of IL-17 by activated T cells in patients with RA could be the result of activation via the PI3K/Akt pathway with resultant NF-κB activation.
T198 28425-28609 Sentence denotes Our data provide insights into cellular mechanisms of the regulation of IL-17 production in RA, and highlight the role of T cells, which has hitherto been neglected in RA pathogenesis.
T199 28610-28796 Sentence denotes Together with recent data on the successful introduction of anti-IL-17 in RA, our results have added information for the future molecular targeting of new therapeutic applications in RA.
T200 28798-28811 Sentence denotes Abbreviations
T201 28812-29395 Sentence denotes AP-1, activator protein-1; BSA = bovine serum albumin; EMSA = electrophoretic mobility-shift assay; GAPDH = glyceraldehyde-3-phosphate dehydrogenase; IL = interleukin; MAPK = mitogen-activated protein kinase; MCP-1 = monocyte chemoattractant protein-1; MIP = macrophage inflammatory protein; NF-κB = nuclear factor κB; OA = osteoarthritis; PBMC = peripheral blood mononuclear cells; PDTC = pyrrolidine dithiocarbamate; PHA = phytohemagglutinin; PI3K = phosphoinositide 3-kinase; RA = rheumatoid arthritis; TGF = transforming growth factor; Th = T helper; TNF = tumor necrosis factor.
T202 29397-29416 Sentence denotes Competing interests
T203 29417-29477 Sentence denotes The author(s) declare that they have no competing interests.
T204 29479-29501 Sentence denotes Authors' contributions
T205 29502-29590 Sentence denotes KWK performed the cellular immune response studies and participated in the immunoassays.
T206 29591-29674 Sentence denotes MLC participated in the design of the study and performed the statistical analysis.
T207 29675-29722 Sentence denotes MKP participated in the isolation of the cells.
T208 29723-29750 Sentence denotes CHY drafted the manuscript.
T209 29751-29808 Sentence denotes SHP participated in the molecular biology and in the PCR.
T210 29809-29913 Sentence denotes SHL conceived the study, participated in its design and coordination and helped to draft the manuscript.
T211 29914-29949 Sentence denotes HYK helped to draft the manuscript.
T212 29950-30001 Sentence denotes All authors read and approved the final manuscript.

ICD10

Id Subject Object Predicate Lexical cue
T1103 129-149 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T1105 140-149 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T19620 27938-27947 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T19619 23842-23851 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T5037 5860-5870 http://purl.bioontology.org/ontology/ICD10/M79.0 denotes Rheumatism
T3567 2431-2440 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T3566 2420-2440 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes Rheumatoid arthritis
T1104 246-266 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T1106 257-266 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

simple1

Id Subject Object Predicate Lexical cue
T1216 10-24 Protein denotes interleukin-17
T1217 68-71 Protein denotes Akt
T8709 12480-12485 Protein denotes GAPDH
T22392 28675-28680 Protein denotes IL-17
T22391 28497-28502 Protein denotes IL-17
T22390 28380-28383 Protein denotes Akt
T22389 28286-28291 Protein denotes IL-17
T22388 28240-28244 Protein denotes CD28
T22387 28194-28199 Protein denotes MCP-1
T22386 28184-28189 Protein denotes IL-15
T22385 28150-28155 Protein denotes IL-17
T19930 27996-28001 Protein denotes IL-17
T19929 27915-27920 Protein denotes IL-17
T19928 27802-27807 Protein denotes IL-17
T19927 27694-27699 Protein denotes IL-17
T19926 27603-27606 Protein denotes Akt
T19925 27544-27549 Protein denotes IL-17
T19924 27413-27416 Protein denotes Akt
T19923 27222-27226 Protein denotes AP-1
T19922 27187-27192 Protein denotes IL-17
T19921 27062-27067 Protein denotes IL-15
T19920 27056-27060 Protein denotes CD28
T19919 26976-26981 Protein denotes IL-17
T19918 26866-26869 Protein denotes Akt
T19917 26784-26787 Protein denotes Akt
T19916 26643-26648 Protein denotes IL-17
T19915 26349-26369 Protein denotes CREB-binding protein
T19914 26344-26348 Protein denotes p300
T19913 26220-26232 Protein denotes IκB kinase-β
T19912 26035-26040 Protein denotes IL-17
T19911 25822-25827 Protein denotes IL-17
T19910 25810-25813 Protein denotes CD3
T19909 25768-25773 Protein denotes IL-17
T19908 25576-25581 Protein denotes IL-17
T19907 25497-25502 Protein denotes IL-17
T19906 25393-25398 Protein denotes IL-17
T19905 25373-25377 Protein denotes CD28
T19904 25139-25144 Protein denotes MCP-1
T19903 25080-25085 Protein denotes TNF-α
T19902 25050-25055 Protein denotes IL-17
T19901 25025-25030 Protein denotes IL-15
T19900 24956-24961 Protein denotes IL-17
T19899 24849-24854 Protein denotes TNF-α
T19898 24840-24844 Protein denotes IL-1
T19897 24795-24800 Protein denotes IL-17
T19896 24763-24768 Protein denotes MCP-1
T19895 24754-24759 Protein denotes IL-15
T19894 24729-24734 Protein denotes IL-17
T19893 24657-24662 Protein denotes MCP-1
T19892 24647-24652 Protein denotes IL-15
T19891 24611-24615 Protein denotes CD28
T19890 24471-24476 Protein denotes IL-17
T19889 24392-24397 Protein denotes IL-17
T19888 24357-24362 Protein denotes IL-23
T19887 24347-24352 Protein denotes IL-15
T19886 24298-24303 Protein denotes IL-17
T19885 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T19884 24135-24139 Protein denotes IL-8
T19883 24129-24133 Protein denotes IL-6
T19882 24051-24056 Protein denotes IL-17
T19881 23735-23740 Protein denotes IL-17
T19880 23652-23657 Protein denotes IL-23
T19879 23632-23635 Protein denotes CD8
T19878 23524-23527 Protein denotes CD4
T19877 23486-23491 Protein denotes IL-17
T19876 23397-23402 Protein denotes IL-17
T19875 23255-23260 Protein denotes IL-17
T19874 23197-23201 Protein denotes CD28
T19873 23155-23158 Protein denotes PHA
T19872 23089-23093 Protein denotes CD28
T19871 23039-23044 Protein denotes IL-17
T19870 22985-22990 Protein denotes IL-17
T19869 22835-22840 Protein denotes IL-17
T19868 22746-22751 Protein denotes IL-17
T19867 22594-22599 Protein denotes IL-17
T19866 22349-22361 Protein denotes interferon-γ
T19865 22340-22344 Protein denotes IL-4
T19864 22248-22253 Protein denotes TNF-α
T19863 22239-22243 Protein denotes IL-1
T19862 22004-22009 Protein denotes IL-17
T16280 21934-21939 Protein denotes IL-17
T16279 21839-21843 Protein denotes CD28
T16278 21769-21773 Protein denotes AP-1
T16277 21697-21702 Protein denotes IκB-α
T16276 21655-21660 Protein denotes IκB-α
T16275 21608-21613 Protein denotes IL-17
T16274 21346-21350 Protein denotes CD28
T16273 21227-21232 Protein denotes c-Rel
T16272 21200-21203 Protein denotes p50
T16271 21192-21195 Protein denotes p65
T16270 21081-21086 Protein denotes IL-17
T16269 21024-21028 Protein denotes CD28
T16268 20931-20936 Protein denotes IL-17
T16267 20806-20811 Protein denotes IL-17
T16266 20770-20775 Protein denotes IL-15
T16265 20762-20765 Protein denotes PHA
T16264 20740-20744 Protein denotes CD28
T16263 20627-20632 Protein denotes IL-17
T16262 20606-20610 Protein denotes AP-1
T16261 20585-20604 Protein denotes activator protein-1
T15176 20440-20443 Protein denotes Akt
T15175 20382-20387 Protein denotes IL-15
T15174 20358-20361 Protein denotes PHA
T15173 20300-20307 Protein denotes β-actin
T15172 20292-20295 Protein denotes Akt
T15171 20136-20139 Protein denotes Akt
T15170 20066-20069 Protein denotes Akt
T15169 19904-19907 Protein denotes Akt
T15168 19780-19785 Protein denotes IL-17
T15167 19745-19748 Protein denotes Akt
T14577 19577-19582 Protein denotes IL-17
T14576 19391-19396 Protein denotes IL-17
T14575 19334-19339 Protein denotes IL-17
T13927 19074-19079 Protein denotes IL-17
T13926 19007-19012 Protein denotes IL-17
T13925 18820-18825 Protein denotes IL-17
T13924 18674-18679 Protein denotes IL-17
T13923 18604-18615 Protein denotes calcineurin
T13922 18486-18491 Protein denotes IL-17
T13921 18197-18202 Protein denotes IL-17
T13920 18023-18028 Protein denotes IL-17
T13919 17917-17922 Protein denotes IL-17
T12911 17873-17879 Protein denotes MIP-1β
T12910 17852-17858 Protein denotes MIP-1α
T12909 17835-17839 Protein denotes IL-8
T12908 17707-17712 Protein denotes IL-17
T12907 17661-17665 Protein denotes IL-6
T12906 17641-17646 Protein denotes MCP-1
T12905 17591-17596 Protein denotes IL-17
T12904 17560-17565 Protein denotes TGF-β
T12903 17540-17545 Protein denotes IL-18
T12902 17522-17527 Protein denotes TNF-α
T12901 17504-17509 Protein denotes IL-1β
T12900 17473-17478 Protein denotes IL-15
T12899 17438-17443 Protein denotes IL-17
T12898 17393-17398 Protein denotes IL-17
T12897 17234-17239 Protein denotes IL-17
T12896 16984-16989 Protein denotes IL-17
T12019 16921-16925 Protein denotes CD28
T12018 16856-16861 Protein denotes IL-17
T12017 16841-16844 Protein denotes PHA
T12016 16728-16733 Protein denotes IL-17
T12015 16696-16700 Protein denotes CD28
T12014 16635-16640 Protein denotes IL-17
T12013 16463-16468 Protein denotes IL-17
T12012 16221-16226 Protein denotes IL-17
T12011 16209-16212 Protein denotes PHA
T12010 16199-16203 Protein denotes CD28
T12009 16130-16135 Protein denotes IL-17
T11399 15966-15969 Protein denotes PHA
T11398 15935-15940 Protein denotes IL-17
T11397 15809-15814 Protein denotes IL-17
T11396 15707-15712 Protein denotes IL-17
T11395 15619-15622 Protein denotes PHA
T11394 15493-15498 Protein denotes IL-17
T10439 14837-14842 Protein denotes c-Rel
T10438 14829-14832 Protein denotes p65
T10437 14824-14827 Protein denotes p50
T10436 13930-13935 Protein denotes IL-17
T9645 13304-13309 Protein denotes IκB-α
T9644 13296-13299 Protein denotes Akt
T9643 13276-13279 Protein denotes Akt
T9642 12549-12554 Protein denotes IκB-α
T9641 12541-12544 Protein denotes Akt
T9640 12521-12524 Protein denotes Akt
T8708 12457-12462 Protein denotes IL-17
T8707 12297-12302 Protein denotes IL-17
T8706 12287-12292 Protein denotes GAPDH
T8705 12186-12191 Protein denotes IL-17
T8704 12176-12181 Protein denotes GAPDH
T8703 11957-11962 Protein denotes GAPDH
T8702 11910-11915 Protein denotes GAPDH
T8701 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8700 11760-11765 Protein denotes IL-17
T8699 11497-11500 Protein denotes Taq
T8698 10920-10925 Protein denotes IL-17
T7810 10878-10883 Protein denotes IL-17
T7809 10631-10636 Protein denotes IL-17
T7808 10583-10588 Protein denotes IL-17
T7807 10140-10145 Protein denotes IL-17
T7806 9885-9890 Protein denotes IL-17
T7805 9669-9674 Protein denotes IL-17
T7804 9463-9468 Protein denotes IL-17
T7803 9457-9462 Protein denotes IL-17
T6952 9400-9403 Protein denotes CD4
T6951 9052-9055 Protein denotes CD4
T6950 8506-8509 Protein denotes CD4
T6949 8357-8360 Protein denotes CD4
T6948 8322-8325 Protein denotes CD4
T6284 7305-7310 Protein denotes IL-17
T5589 7106-7110 Protein denotes CD28
T5588 6921-6924 Protein denotes PHA
T5587 6901-6919 Protein denotes Phytohemagglutinin
T5586 6777-6781 Protein denotes IL-1
T5585 6767-6772 Protein denotes TNF-α
T5584 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5583 6602-6606 Protein denotes IL-8
T5582 6593-6597 Protein denotes IL-6
T5581 6585-6591 Protein denotes MIP-1β
T5580 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5579 6535-6540 Protein denotes MCP-1
T5578 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5577 6492-6497 Protein denotes IL-15
T5576 6485-6490 Protein denotes IL-18
T5575 6478-6483 Protein denotes IL-17
T3685 5506-5511 Protein denotes IL-17
T3684 5419-5422 Protein denotes Akt
T3683 5241-5246 Protein denotes IL-17
T3682 5145-5150 Protein denotes IL-17
T3681 5010-5015 Protein denotes IL-17
T3680 4962-4965 Protein denotes CD8
T3679 4953-4956 Protein denotes CD4
T3678 4926-4931 Protein denotes IL-17
T3677 4887-4892 Protein denotes IL-23
T3676 4720-4725 Protein denotes IL-17
T3675 4628-4633 Protein denotes IL-15
T3674 4590-4593 Protein denotes CD4
T3673 4453-4458 Protein denotes IL-17
T3672 4263-4289 Protein denotes leukemia inhibitory factor
T3671 4254-4258 Protein denotes IL-6
T3670 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3669 4108-4113 Protein denotes RANKL
T3668 4035-4040 Protein denotes IL-17
T3667 3920-3925 Protein denotes IL-17
T3666 3914-3918 Protein denotes IL-1
T3665 3904-3909 Protein denotes TNF-α
T3664 3807-3811 Protein denotes IL-8
T3663 3798-3802 Protein denotes IL-6
T3662 3700-3705 Protein denotes IL-17
T3661 3325-3330 Protein denotes TNF-α
T3660 3315-3320 Protein denotes IL-18
T3659 3308-3313 Protein denotes IL-15
T3658 3302-3306 Protein denotes IL-6
T3657 3296-3300 Protein denotes IL-1
T3656 3208-3220 Protein denotes interferon-γ
T3655 3199-3203 Protein denotes IL-2
T3654 2762-2780 Protein denotes interleukin (IL)-1
T3653 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T1250 2393-2398 Protein denotes IL-17
T1249 2311-2314 Protein denotes Akt
T1248 2219-2224 Protein denotes IL-17
T1247 2202-2203 Protein denotes 2
T1246 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T1245 2138-2157 Protein denotes activator protein-1
T1244 2062-2065 Protein denotes Akt
T1243 1912-1917 Protein denotes IL-17
T1242 1783-1786 Protein denotes Akt
T1241 1610-1615 Protein denotes IL-17
T1240 1572-1600 Protein denotes transforming growth factor-β
T1239 1563-1568 Protein denotes IL-18
T1238 1556-1561 Protein denotes IL-1β
T1237 1531-1554 Protein denotes tumor necrosis factor-α
T1236 1494-1499 Protein denotes IL-17
T1235 1477-1481 Protein denotes IL-6
T1234 1438-1472 Protein denotes monocyte chemoattractant protein-1
T1233 1431-1436 Protein denotes IL-15
T1232 1376-1379 Protein denotes PHA
T1231 1367-1371 Protein denotes CD28
T1230 1272-1277 Protein denotes IL-17
T1229 1126-1131 Protein denotes IL-17
T1228 1070-1073 Protein denotes PHA
T1227 1050-1068 Protein denotes phytohemagglutinin
T1226 1044-1048 Protein denotes CD28
T1225 870-875 Protein denotes IL-17
T1224 837-840 Protein denotes Akt
T1223 717-722 Protein denotes IL-17
T1222 648-653 Protein denotes IL-17
T1221 610-615 Protein denotes IL-23
T1220 600-605 Protein denotes IL-15
T1219 504-509 Protein denotes IL-17
T1218 273-292 Protein denotes Interleukin (IL)-17

DLUT931

Id Subject Object Predicate Lexical cue
T1336 10-24 Protein denotes interleukin-17
T1337 68-71 Protein denotes Akt
T1371 25-35 Gene_expression denotes production
T1372 0-9 Positive_regulation denotes Increased
T22430 28654-28666 Gene_expression denotes introduction
T22429 28483-28493 Regulation denotes regulation
T22428 28503-28513 Gene_expression denotes production
T22427 28270-28282 Positive_regulation denotes upregulation
T22426 28125-28135 Positive_regulation denotes pronounced
T22425 28172-28180 Positive_regulation denotes response
T22424 28136-28146 Gene_expression denotes production
T22423 28675-28680 Protein denotes IL-17
T22422 28497-28502 Protein denotes IL-17
T22421 28380-28383 Protein denotes Akt
T22420 28286-28291 Protein denotes IL-17
T22419 28240-28244 Protein denotes CD28
T22418 28194-28199 Protein denotes MCP-1
T22417 28184-28189 Protein denotes IL-15
T22416 28150-28155 Protein denotes IL-17
T20286 27897-27906 Positive_regulation denotes induction
T20285 27678-27690 Positive_regulation denotes upregulation
T20284 27554-27561 Negative_regulation denotes lacking
T20283 27535-27543 Positive_regulation denotes inducing
T20282 27420-27431 Binding denotes association
T20281 27326-27335 Positive_regulation denotes activated
T20280 27158-27166 Regulation denotes involved
T20279 27174-27183 Positive_regulation denotes induction
T20278 26936-26947 Regulation denotes involvement
T20274 26788-26798 Positive_regulation denotes activation
T20273 26649-26659 Gene_expression denotes production
T20272 26236-26245 Positive_regulation denotes activated
T20271 26056-26069 Negative_regulation denotes downregulated
T20270 26018-26034 Positive_regulation denotes anti-CD3-induced
T20269 26041-26051 Gene_expression denotes production
T20268 25868-25876 Negative_regulation denotes hampered
T20267 25814-25821 Positive_regulation denotes induced
T20266 25828-25838 Gene_expression denotes production
T20265 25739-25747 Regulation denotes involved
T20264 25755-25764 Positive_regulation denotes induction
T20263 25600-25609 Regulation denotes regulated
T20262 25582-25592 Gene_expression denotes production
T20261 25460-25469 Positive_regulation denotes induction
T20260 25399-25408 Positive_regulation denotes induction
T20259 25031-25040 Positive_regulation denotes triggered
T20258 25056-25066 Gene_expression denotes production
T20257 24949-24955 Regulation denotes affect
T20256 24962-24972 Gene_expression denotes production
T20255 24785-24794 Positive_regulation denotes augmented
T20254 24801-24811 Gene_expression denotes production
T20253 24747-24753 Positive_regulation denotes Adding
T20252 24701-24710 Positive_regulation denotes increased
T20251 24715-24725 Gene_expression denotes production
T20250 24457-24467 Gene_expression denotes production
T20249 24383-24391 Regulation denotes regulate
T20248 24288-24297 Positive_regulation denotes stimulate
T20247 24398-24408 Gene_expression denotes production
T20246 24304-24314 Gene_expression denotes production
T20245 24095-24102 Localization denotes secrete
T20244 23770-23779 Positive_regulation denotes augmented
T20243 23741-23751 Gene_expression denotes production
T20242 23620-23628 Gene_expression denotes produced
T20241 23495-23503 Gene_expression denotes produced
T20240 23381-23393 Positive_regulation denotes upregulation
T20239 23245-23254 Positive_regulation denotes increased
T20238 23261-23271 Gene_expression denotes production
T20237 22975-22984 Positive_regulation denotes stimulate
T20236 23045-23055 Gene_expression denotes production
T20235 22991-23001 Gene_expression denotes production
T20234 22766-22775 Regulation denotes regulated
T20233 22752-22762 Gene_expression denotes production
T20232 27996-28001 Protein denotes IL-17
T20231 27915-27920 Protein denotes IL-17
T20230 27802-27807 Protein denotes IL-17
T20229 27694-27699 Protein denotes IL-17
T20228 27603-27606 Protein denotes Akt
T20227 27544-27549 Protein denotes IL-17
T20226 27413-27416 Protein denotes Akt
T20225 27222-27226 Protein denotes AP-1
T20224 27187-27192 Protein denotes IL-17
T20223 27062-27067 Protein denotes IL-15
T20222 27056-27060 Protein denotes CD28
T20221 26976-26981 Protein denotes IL-17
T20220 26866-26869 Protein denotes Akt
T20219 26784-26787 Protein denotes Akt
T20218 26643-26648 Protein denotes IL-17
T20217 26349-26369 Protein denotes CREB-binding protein
T20216 26344-26348 Protein denotes p300
T20215 26220-26232 Protein denotes IκB kinase-β
T20214 26035-26040 Protein denotes IL-17
T20213 25822-25827 Protein denotes IL-17
T20212 25810-25813 Protein denotes CD3
T20211 25768-25773 Protein denotes IL-17
T20210 25576-25581 Protein denotes IL-17
T20209 25497-25502 Protein denotes IL-17
T20208 25393-25398 Protein denotes IL-17
T20207 25373-25377 Protein denotes CD28
T20206 25139-25144 Protein denotes MCP-1
T20205 25080-25085 Protein denotes TNF-α
T20204 25050-25055 Protein denotes IL-17
T20203 25025-25030 Protein denotes IL-15
T20202 24956-24961 Protein denotes IL-17
T20201 24849-24854 Protein denotes TNF-α
T20200 24840-24844 Protein denotes IL-1
T20199 24795-24800 Protein denotes IL-17
T20198 24763-24768 Protein denotes MCP-1
T20197 24754-24759 Protein denotes IL-15
T20196 24729-24734 Protein denotes IL-17
T20195 24657-24662 Protein denotes MCP-1
T20194 24647-24652 Protein denotes IL-15
T20193 24611-24615 Protein denotes CD28
T20192 24471-24476 Protein denotes IL-17
T20191 24392-24397 Protein denotes IL-17
T20190 24357-24362 Protein denotes IL-23
T20189 24347-24352 Protein denotes IL-15
T20188 24298-24303 Protein denotes IL-17
T20187 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T20186 24135-24139 Protein denotes IL-8
T20185 24129-24133 Protein denotes IL-6
T20184 24051-24056 Protein denotes IL-17
T20183 23735-23740 Protein denotes IL-17
T20182 23652-23657 Protein denotes IL-23
T20181 23632-23635 Protein denotes CD8
T20180 23524-23527 Protein denotes CD4
T20179 23486-23491 Protein denotes IL-17
T20178 23397-23402 Protein denotes IL-17
T20177 23255-23260 Protein denotes IL-17
T20176 23197-23201 Protein denotes CD28
T20175 23155-23158 Protein denotes PHA
T20174 22985-22990 Protein denotes IL-17
T20173 23089-23093 Protein denotes CD28
T20172 23039-23044 Protein denotes IL-17
T20171 22835-22840 Protein denotes IL-17
T20170 22746-22751 Protein denotes IL-17
T20169 22594-22599 Protein denotes IL-17
T20168 22349-22361 Protein denotes interferon-γ
T20167 22340-22344 Protein denotes IL-4
T20166 22248-22253 Protein denotes TNF-α
T20165 22239-22243 Protein denotes IL-1
T20164 22004-22009 Protein denotes IL-17
T16373 21954-21963 Positive_regulation denotes activated
T16372 21940-21950 Gene_expression denotes production
T16371 21790-21799 Positive_regulation denotes activated
T16370 21668-21678 Negative_regulation denotes inhibition
T16369 21682-21693 Protein_catabolism denotes degradation
T16368 21580-21591 Binding denotes DNA-binding
T16367 21051-21060 Positive_regulation denotes increased
T16366 21061-21068 Binding denotes binding
T16365 20797-20805 Positive_regulation denotes inducing
T16364 20812-20822 Gene_expression denotes expression
T16363 20557-20567 Positive_regulation denotes Activation
T16362 21934-21939 Protein denotes IL-17
T16361 21839-21843 Protein denotes CD28
T16360 21769-21773 Protein denotes AP-1
T16359 21697-21702 Protein denotes IκB-α
T16358 21655-21660 Protein denotes IκB-α
T16357 21608-21613 Protein denotes IL-17
T16356 21346-21350 Protein denotes CD28
T16355 21227-21232 Protein denotes c-Rel
T16354 21200-21203 Protein denotes p50
T16353 21192-21195 Protein denotes p65
T16352 21024-21028 Protein denotes CD28
T16351 21081-21086 Protein denotes IL-17
T16350 20931-20936 Protein denotes IL-17
T16349 20806-20811 Protein denotes IL-17
T16348 20770-20775 Protein denotes IL-15
T16347 20762-20765 Protein denotes PHA
T16346 20740-20744 Protein denotes CD28
T16345 20627-20632 Protein denotes IL-17
T16344 20606-20610 Protein denotes AP-1
T16343 20585-20604 Protein denotes activator protein-1
T15230 20415-20421 Regulation denotes effect
T15229 20425-20439 Phosphorylation denotes phosphorylated
T15228 20273-20291 Phosphorylation denotes non-phosphorylated
T15227 20140-20149 Positive_regulation denotes increased
T15226 20121-20135 Phosphorylation denotes phosphorylated
T15225 20051-20065 Phosphorylation denotes phosphorylated
T15224 20022-20032 Regulation denotes difference
T15223 19890-19900 Positive_regulation denotes activation
T15222 19726-19736 Positive_regulation denotes Activation
T15221 19786-19796 Gene_expression denotes production
T15220 20382-20387 Protein denotes IL-15
T15219 20358-20361 Protein denotes PHA
T15218 20440-20443 Protein denotes Akt
T15217 20300-20307 Protein denotes β-actin
T15216 20292-20295 Protein denotes Akt
T15215 20136-20139 Protein denotes Akt
T15214 20066-20069 Protein denotes Akt
T15213 19904-19907 Protein denotes Akt
T15212 19780-19785 Protein denotes IL-17
T15211 19745-19748 Protein denotes Akt
T14606 19550-19564 Regulation denotes dose-dependent
T14605 19565-19573 Positive_regulation denotes increase
T14604 19588-19599 Transcription denotes transcripts
T14603 19417-19426 Regulation denotes regulated
T14602 19382-19390 Positive_regulation denotes enhanced
T14601 19397-19407 Gene_expression denotes production
T14600 19345-19355 Gene_expression denotes expression
T14599 19577-19582 Protein denotes IL-17
T14598 19391-19396 Protein denotes IL-17
T14597 19334-19339 Protein denotes IL-17
T14000 19059-19070 Negative_regulation denotes inhibitions
T13999 19080-19090 Gene_expression denotes production
T13998 18993-19003 Negative_regulation denotes inhibition
T13997 19013-19023 Gene_expression denotes production
T13996 18656-18669 Negative_regulation denotes downregulated
T13995 18680-18689 Localization denotes secretion
T13994 18616-18626 Negative_regulation denotes inhibitors
T13993 18469-18485 Positive_regulation denotes anti-CD3-induced
T13992 18455-18464 Negative_regulation denotes inhibited
T13991 18492-18502 Gene_expression denotes production
T13990 18168-18176 Negative_regulation denotes decrease
T13989 18180-18196 Positive_regulation denotes anti-CD3-induced
T13988 18203-18213 Gene_expression denotes production
T13987 18013-18022 Positive_regulation denotes increased
T13986 18029-18039 Gene_expression denotes production
T13985 17903-17913 Negative_regulation denotes Inhibition
T13984 17923-17933 Gene_expression denotes production
T13983 19074-19079 Protein denotes IL-17
T13982 19007-19012 Protein denotes IL-17
T13981 18820-18825 Protein denotes IL-17
T13980 18674-18679 Protein denotes IL-17
T13979 18604-18615 Protein denotes calcineurin
T13978 18486-18491 Protein denotes IL-17
T13977 18197-18202 Protein denotes IL-17
T13976 18023-18028 Protein denotes IL-17
T13975 17917-17922 Protein denotes IL-17
T12974 17690-17703 Positive_regulation denotes upregulations
T12973 17456-17467 Positive_regulation denotes stimulation
T12972 17426-17434 Positive_regulation denotes increase
T12971 17346-17353 Regulation denotes effects
T12970 17399-17409 Gene_expression denotes production
T12969 17207-17215 Regulation denotes affected
T12968 17220-17230 Gene_expression denotes production
T12967 16970-16980 Regulation denotes Regulation
T12966 16990-17000 Gene_expression denotes production
T12965 17873-17879 Protein denotes MIP-1β
T12964 17852-17858 Protein denotes MIP-1α
T12963 17835-17839 Protein denotes IL-8
T12962 17707-17712 Protein denotes IL-17
T12961 17661-17665 Protein denotes IL-6
T12960 17641-17646 Protein denotes MCP-1
T12959 17560-17565 Protein denotes TGF-β
T12958 17540-17545 Protein denotes IL-18
T12957 17522-17527 Protein denotes TNF-α
T12956 17504-17509 Protein denotes IL-1β
T12955 17473-17478 Protein denotes IL-15
T12954 17438-17443 Protein denotes IL-17
T12953 17591-17596 Protein denotes IL-17
T12952 17393-17398 Protein denotes IL-17
T12951 17234-17239 Protein denotes IL-17
T12950 16984-16989 Protein denotes IL-17
T12097 16846-16855 Positive_regulation denotes increased
T12096 16882-16892 Positive_regulation denotes pronounced
T12095 16862-16872 Gene_expression denotes production
T12094 16623-16634 Positive_regulation denotes upregulated
T12093 16714-16722 Gene_expression denotes produced
T12092 16641-16651 Gene_expression denotes production
T12091 16436-16450 Regulation denotes dose-dependent
T12090 16451-16459 Positive_regulation denotes increase
T12089 16272-16280 Gene_expression denotes produced
T12088 16120-16129 Positive_regulation denotes Increased
T12087 16136-16146 Gene_expression denotes production
T12086 16841-16844 Protein denotes PHA
T12085 16921-16925 Protein denotes CD28
T12084 16856-16861 Protein denotes IL-17
T12083 16728-16733 Protein denotes IL-17
T12082 16696-16700 Protein denotes CD28
T12081 16635-16640 Protein denotes IL-17
T12080 16463-16468 Protein denotes IL-17
T12079 16221-16226 Protein denotes IL-17
T12078 16209-16212 Protein denotes PHA
T12077 16199-16203 Protein denotes CD28
T12076 16130-16135 Protein denotes IL-17
T11425 15988-15994 Positive_regulation denotes higher
T11424 15952-15962 Positive_regulation denotes stimulated
T11423 15941-15951 Gene_expression denotes production
T11422 15815-15824 Localization denotes secretion
T11421 15499-15509 Gene_expression denotes production
T11420 15966-15969 Protein denotes PHA
T11419 15935-15940 Protein denotes IL-17
T11418 15809-15814 Protein denotes IL-17
T11417 15707-15712 Protein denotes IL-17
T11416 15619-15622 Protein denotes PHA
T11415 15493-15498 Protein denotes IL-17
T10452 14837-14842 Protein denotes c-Rel
T10451 14829-14832 Protein denotes p65
T10450 14824-14827 Protein denotes p50
T10449 13930-13935 Protein denotes IL-17
T9677 13281-13295 Phosphorylation denotes phosphorylated
T9676 12526-12540 Phosphorylation denotes phosphorylated
T9675 13304-13309 Protein denotes IκB-α
T9674 13296-13299 Protein denotes Akt
T9673 13276-13279 Protein denotes Akt
T9672 12549-12554 Protein denotes IκB-α
T9671 12541-12544 Protein denotes Akt
T9670 12521-12524 Protein denotes Akt
T8753 12486-12493 Gene_expression denotes product
T8752 11963-11972 Negative_regulation denotes antisense
T8751 10902-10916 Positive_regulation denotes Quantification
T8750 12480-12485 Protein denotes GAPDH
T8749 12457-12462 Protein denotes IL-17
T8748 12287-12292 Protein denotes GAPDH
T8747 12297-12302 Protein denotes IL-17
T6971 9052-9055 Protein denotes CD4
T6970 8506-8509 Protein denotes CD4
T6969 8357-8360 Protein denotes CD4
T6968 8322-8325 Protein denotes CD4
T6291 7330-7340 Positive_regulation denotes activation
T6290 7291-7301 Gene_expression denotes Production
T6289 7305-7310 Protein denotes IL-17
T5649 7106-7110 Protein denotes CD28
T5648 6921-6924 Protein denotes PHA
T5647 6901-6919 Protein denotes Phytohemagglutinin
T5646 6777-6781 Protein denotes IL-1
T5645 6767-6772 Protein denotes TNF-α
T5644 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5643 6602-6606 Protein denotes IL-8
T5642 6593-6597 Protein denotes IL-6
T5641 6585-6591 Protein denotes MIP-1β
T5640 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5639 6535-6540 Protein denotes MCP-1
T5638 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5637 6492-6497 Protein denotes IL-15
T5636 6485-6490 Protein denotes IL-18
T5635 6478-6483 Protein denotes IL-17
T3812 5442-5450 Regulation denotes involved
T3811 5458-5472 Gene_expression denotes overproduction
T3810 5247-5257 Gene_expression denotes production
T3809 5151-5161 Gene_expression denotes production
T3808 4915-4922 Positive_regulation denotes trigger
T3807 4932-4942 Gene_expression denotes production
T3806 4709-4716 Positive_regulation denotes trigger
T3805 4726-4736 Gene_expression denotes production
T3804 4649-4658 Positive_regulation denotes activated
T3803 4635-4643 Localization denotes secreted
T3802 4225-4235 Positive_regulation denotes stimulates
T3801 4240-4250 Gene_expression denotes production
T3800 4050-4058 Positive_regulation denotes activate
T3799 4181-4189 Regulation denotes involved
T3798 4095-4104 Positive_regulation denotes induction
T3797 3791-3797 Positive_regulation denotes induce
T3796 3743-3751 Localization denotes secreted
T3795 2713-2723 Negative_regulation denotes inhibitors
T3794 5506-5511 Protein denotes IL-17
T3793 5419-5422 Protein denotes Akt
T3792 5241-5246 Protein denotes IL-17
T3791 5145-5150 Protein denotes IL-17
T3790 5010-5015 Protein denotes IL-17
T3789 4962-4965 Protein denotes CD8
T3788 4953-4956 Protein denotes CD4
T3787 4926-4931 Protein denotes IL-17
T3786 4887-4892 Protein denotes IL-23
T3785 4720-4725 Protein denotes IL-17
T3784 4628-4633 Protein denotes IL-15
T3783 4590-4593 Protein denotes CD4
T3782 4453-4458 Protein denotes IL-17
T3781 4263-4289 Protein denotes leukemia inhibitory factor
T3780 4254-4258 Protein denotes IL-6
T3779 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T3778 4108-4113 Protein denotes RANKL
T3777 4035-4040 Protein denotes IL-17
T3776 3920-3925 Protein denotes IL-17
T3775 3914-3918 Protein denotes IL-1
T3774 3904-3909 Protein denotes TNF-α
T3773 3807-3811 Protein denotes IL-8
T3772 3798-3802 Protein denotes IL-6
T3771 3700-3705 Protein denotes IL-17
T3770 3325-3330 Protein denotes TNF-α
T3769 3315-3320 Protein denotes IL-18
T3768 3308-3313 Protein denotes IL-15
T3767 3302-3306 Protein denotes IL-6
T3766 3296-3300 Protein denotes IL-1
T3765 3208-3220 Protein denotes interferon-γ
T3764 3199-3203 Protein denotes IL-2
T3763 2762-2780 Protein denotes interleukin (IL)-1
T3762 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T1392 2345-2359 Gene_expression denotes overproduction
T1391 2212-2218 Regulation denotes affect
T1390 2225-2235 Gene_expression denotes production
T1389 2124-2134 Negative_regulation denotes inhibition
T1388 1974-1981 Negative_regulation denotes blocked
T1387 1932-1941 Positive_regulation denotes activated
T1386 1918-1928 Gene_expression denotes production
T1385 1689-1699 Gene_expression denotes expression
T1384 1482-1493 Positive_regulation denotes upregulated
T1383 1500-1510 Gene_expression denotes production
T1382 1296-1305 Positive_regulation denotes increased
T1381 1258-1268 Gene_expression denotes production
T1380 792-796 Regulation denotes role
T1379 856-866 Regulation denotes regulation
T1378 876-886 Gene_expression denotes production
T1377 708-716 Regulation denotes regulate
T1376 639-647 Regulation denotes regulate
T1375 723-733 Gene_expression denotes production
T1374 654-664 Gene_expression denotes production
T1373 461-471 Gene_expression denotes expression
T1370 2393-2398 Protein denotes IL-17
T1369 2311-2314 Protein denotes Akt
T1368 2219-2224 Protein denotes IL-17
T1367 2202-2203 Protein denotes 2
T1366 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T1365 2138-2157 Protein denotes activator protein-1
T1364 2062-2065 Protein denotes Akt
T1363 1912-1917 Protein denotes IL-17
T1362 1783-1786 Protein denotes Akt
T1361 1610-1615 Protein denotes IL-17
T1360 1572-1600 Protein denotes transforming growth factor-β
T1359 1563-1568 Protein denotes IL-18
T1358 1556-1561 Protein denotes IL-1β
T1357 1531-1554 Protein denotes tumor necrosis factor-α
T1356 1494-1499 Protein denotes IL-17
T1355 1477-1481 Protein denotes IL-6
T1354 1438-1472 Protein denotes monocyte chemoattractant protein-1
T1353 1431-1436 Protein denotes IL-15
T1352 1376-1379 Protein denotes PHA
T1351 1367-1371 Protein denotes CD28
T1350 1272-1277 Protein denotes IL-17
T1349 1126-1131 Protein denotes IL-17
T1348 1070-1073 Protein denotes PHA
T1347 1050-1068 Protein denotes phytohemagglutinin
T1346 1044-1048 Protein denotes CD28
T1345 837-840 Protein denotes Akt
T1344 870-875 Protein denotes IL-17
T1343 717-722 Protein denotes IL-17
T1342 648-653 Protein denotes IL-17
T1341 610-615 Protein denotes IL-23
T1340 600-605 Protein denotes IL-15
T1339 504-509 Protein denotes IL-17
T1338 273-292 Protein denotes Interleukin (IL)-17
T7828 9463-9468 Protein denotes IL-17
T7827 9457-9462 Protein denotes IL-17
T6972 9400-9403 Protein denotes CD4
T8746 12186-12191 Protein denotes IL-17
T8745 12176-12181 Protein denotes GAPDH
T8744 11957-11962 Protein denotes GAPDH
T8743 11910-11915 Protein denotes GAPDH
T8742 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8741 11760-11765 Protein denotes IL-17
T8740 11497-11500 Protein denotes Taq
T8739 10920-10925 Protein denotes IL-17
T7834 10878-10883 Protein denotes IL-17
T7833 10631-10636 Protein denotes IL-17
T7832 10583-10588 Protein denotes IL-17
T7831 10140-10145 Protein denotes IL-17
T7830 9885-9890 Protein denotes IL-17
T7829 9669-9674 Protein denotes IL-17
T20276 26873-26887 Phosphorylation denotes phosphorylated
T20275 26772-26780 Regulation denotes response
T20277 26963-26972 Positive_regulation denotes induction
R543 T1336 T1371 themeOf interleukin-17,production
R544 T1339 T1373 themeOf IL-17,expression
R545 T1342 T1374 themeOf IL-17,production
R546 T1343 T1375 themeOf IL-17,production
R547 T1344 T1378 themeOf IL-17,production
R548 T1350 T1381 themeOf IL-17,production
R559 T1371 T1372 themeOf production,Increased
R560 T1374 T1376 themeOf production,regulate
R561 T1375 T1377 themeOf production,regulate
R562 T1378 T1379 themeOf production,regulation
R563 T1379 T1380 themeOf regulation,role
R1802 T3791 T3809 themeOf IL-17,production
R1803 T3792 T3810 themeOf IL-17,production
R1804 T3794 T3811 themeOf IL-17,overproduction
R1806 T3798 T3799 themeOf induction,involved
R1807 T3798 T3800 themeOf induction,activate
R1809 T3801 T3802 themeOf production,stimulates
R1810 T3801 T3802 themeOf production,stimulates
R1811 T3803 T3804 themeOf secreted,activated
R1813 T3805 T3806 themeOf production,trigger
R1814 T3807 T3808 themeOf production,trigger
R1816 T3811 T3812 themeOf overproduction,involved
R3325 T6289 T6290 themeOf IL-17,Production
R3326 T6290 T6291 themeOf Production,activation
R4482 T8739 T8751 themeOf IL-17,Quantification
R4483 T8741 T8752 themeOf IL-17,antisense
R4484 T8744 T8752 themeOf GAPDH,antisense
R4485 T8750 T8753 themeOf GAPDH,product
R5073 T9671 T9676 themeOf Akt,phosphorylated
R5074 T9673 T9677 themeOf Akt,phosphorylated
R5075 T9674 T9677 themeOf Akt,phosphorylated
R5076 T9675 T9677 themeOf IκB-α,phosphorylated
R6152 T11415 T11421 themeOf IL-17,production
R6153 T11418 T11422 themeOf IL-17,secretion
R6154 T11419 T11423 themeOf IL-17,production
R6155 T11420 T11425 themeOf PHA,higher
R6156 T11423 T11424 themeOf production,stimulated
R6519 T12076 T12087 themeOf IL-17,production
R6520 T12078 T12087 themeOf PHA,production
R6521 T12079 T12089 themeOf IL-17,produced
R6522 T12080 T12090 themeOf IL-17,increase
R6523 T12081 T12092 themeOf IL-17,production
R6524 T12083 T12093 themeOf IL-17,produced
R6525 T12084 T12095 themeOf IL-17,production
R6526 T12087 T12088 themeOf production,Increased
R6527 T12087 T12088 themeOf production,Increased
R6528 T12090 T12091 themeOf increase,dose-dependent
R6529 T12091 T12090 themeOf dose-dependent,increase
R6530 T12092 T12094 themeOf production,upregulated
R6531 T12095 T12096 themeOf production,pronounced
R6532 T12095 T12097 themeOf production,increased
R6533 T12097 T12096 themeOf increased,pronounced
R7006 T12950 T12966 themeOf IL-17,production
R7007 T12951 T12968 themeOf IL-17,production
R7008 T12952 T12970 themeOf IL-17,production
R7009 T12954 T12972 themeOf IL-17,increase
R7010 T12955 T12973 themeOf IL-15,stimulation
R7011 T12962 T12974 themeOf IL-17,upregulations
R7012 T12966 T12967 themeOf production,Regulation
R7013 T12968 T12969 themeOf production,affected
R7014 T12970 T12971 themeOf production,effects
R7607 T13975 T13984 themeOf IL-17,production
R7608 T13976 T13986 themeOf IL-17,production
R7609 T13977 T13988 themeOf IL-17,production
R7610 T13978 T13991 themeOf IL-17,production
R7611 T13979 T13994 themeOf calcineurin,inhibitors
R7612 T13980 T13995 themeOf IL-17,secretion
R7613 T13982 T13997 themeOf IL-17,production
R7614 T13983 T13999 themeOf IL-17,production
R7615 T13984 T13985 themeOf production,Inhibition
R7616 T13986 T13987 themeOf production,increased
R7617 T13988 T13989 themeOf production,anti-CD3-induced
R7618 T13989 T13990 themeOf anti-CD3-induced,decrease
R7619 T13991 T13992 themeOf production,inhibited
R7620 T13991 T13993 themeOf production,anti-CD3-induced
R7621 T13993 T13992 themeOf anti-CD3-induced,inhibited
R7622 T13994 T13996 causeOf inhibitors,downregulated
R7623 T13995 T13996 themeOf secretion,downregulated
R7624 T13997 T13998 themeOf production,inhibition
R7625 T13999 T14000 themeOf production,inhibitions
R8047 T14597 T14600 themeOf IL-17,expression
R8048 T14598 T14601 themeOf IL-17,production
R8049 T14599 T14604 themeOf IL-17,transcripts
R8050 T14601 T14602 themeOf production,enhanced
R8051 T14602 T14603 themeOf enhanced,regulated
R8052 T14604 T14605 themeOf transcripts,increase
R8053 T14605 T14606 themeOf increase,dose-dependent
R8054 T14606 T14605 themeOf dose-dependent,increase
R8340 T15212 T15221 themeOf IL-17,production
R8341 T15213 T15223 themeOf Akt,activation
R8342 T15214 T15224 themeOf Akt,difference
R8343 T15214 T15225 themeOf Akt,phosphorylated
R8344 T15215 T15226 themeOf Akt,phosphorylated
R8345 T15215 T15227 themeOf Akt,increased
R8346 T15216 T15228 themeOf Akt,non-phosphorylated
R8347 T15217 T15228 themeOf β-actin,non-phosphorylated
R8348 T15218 T15229 themeOf Akt,phosphorylated
R8349 T15219 T15230 causeOf PHA,effect
R8350 T15220 T15230 causeOf IL-15,effect
R8351 T15221 T15222 themeOf production,Activation
R8352 T15225 T15224 themeOf phosphorylated,difference
R8353 T15226 T15227 themeOf phosphorylated,increased
R8354 T15229 T15230 themeOf phosphorylated,effect
R8355 T15229 T15230 themeOf phosphorylated,effect
R8871 T16343 T16363 themeOf activator protein-1,Activation
R8872 T16349 T16364 themeOf IL-17,expression
R8873 T16351 T16366 themeOf IL-17,binding
R8874 T16357 T16368 themeOf IL-17,DNA-binding
R8875 T16359 T16369 themeOf IκB-α,degradation
R8876 T16360 T16371 themeOf AP-1,activated
R8877 T16362 T16372 themeOf IL-17,production
R8878 T16364 T16365 themeOf expression,inducing
R8879 T16366 T16367 themeOf binding,increased
R8880 T16369 T16370 themeOf degradation,inhibition
R8881 T16372 T16373 themeOf production,activated
R10663 T20170 T20233 themeOf IL-17,production
R10664 T20172 T20236 themeOf IL-17,production
R10665 T20174 T20235 themeOf IL-17,production
R10666 T20175 T20239 causeOf PHA,increased
R10667 T20177 T20238 themeOf IL-17,production
R10668 T20178 T20240 themeOf IL-17,upregulation
R10669 T20179 T20241 themeOf IL-17,produced
R10670 T20182 T20242 themeOf IL-23,produced
R10671 T20183 T20243 themeOf IL-17,production
R10672 T20184 T20245 themeOf IL-17,secrete
R10673 T20185 T20245 themeOf IL-6,secrete
R10674 T20186 T20245 themeOf IL-8,secrete
R10675 T20187 T20245 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10676 T20188 T20246 themeOf IL-17,production
R10677 T20191 T20247 themeOf IL-17,production
R10678 T20192 T20250 themeOf IL-17,production
R10679 T20194 T20252 causeOf IL-15,increased
R10680 T20195 T20252 causeOf MCP-1,increased
R10681 T20196 T20251 themeOf IL-17,production
R10682 T20197 T20253 themeOf IL-15,Adding
R10683 T20198 T20253 themeOf MCP-1,Adding
R10684 T20199 T20254 themeOf IL-17,production
R10685 T20200 T20257 causeOf IL-1,affect
R10686 T20201 T20257 causeOf TNF-α,affect
R10687 T20202 T20256 themeOf IL-17,production
R10688 T20203 T20259 causeOf IL-15,triggered
R10689 T20204 T20258 themeOf IL-17,production
R10690 T20208 T20260 themeOf IL-17,induction
R10691 T20209 T20261 themeOf IL-17,induction
R10692 T20210 T20262 themeOf IL-17,production
R10693 T20211 T20264 themeOf IL-17,induction
R10694 T20212 T20267 causeOf CD3,induced
R10695 T20213 T20266 themeOf IL-17,production
R10696 T20214 T20269 themeOf IL-17,production
R10697 T20215 T20272 themeOf IκB kinase-β,activated
R10698 T20218 T20273 themeOf IL-17,production
R10699 T20219 T20274 themeOf Akt,activation
R10700 T20220 T20276 themeOf Akt,phosphorylated
R10701 T20221 T20277 themeOf IL-17,induction
R10702 T20224 T20279 themeOf IL-17,induction
R10703 T20225 T20281 themeOf AP-1,activated
R10704 T20226 T20282 themeOf Akt,association
R10705 T20227 T20283 themeOf IL-17,inducing
R10706 T20229 T20285 themeOf IL-17,upregulation
R10707 T20231 T20286 themeOf IL-17,induction
R10708 T20233 T20234 themeOf production,regulated
R10709 T20235 T20237 themeOf production,stimulate
R10710 T20238 T20239 themeOf production,increased
R10711 T20243 T20244 themeOf production,augmented
R10712 T20246 T20248 themeOf production,stimulate
R10713 T20247 T20249 themeOf production,regulate
R10714 T20251 T20252 themeOf production,increased
R10715 T20251 T20252 themeOf production,increased
R10716 T20254 T20255 themeOf production,augmented
R10717 T20256 T20257 themeOf production,affect
R10718 T20256 T20257 themeOf production,affect
R10719 T20258 T20259 themeOf production,triggered
R10720 T20262 T20263 themeOf production,regulated
R10721 T20264 T20265 themeOf induction,involved
R10722 T20266 T20267 themeOf production,induced
R10723 T20267 T20268 themeOf induced,hampered
R10724 T20269 T20270 themeOf production,anti-CD3-induced
R10725 T20270 T20271 themeOf anti-CD3-induced,downregulated
R10726 T20274 T20275 themeOf activation,response
R10727 T20277 T20278 themeOf induction,involvement
R10728 T20279 T20280 themeOf induction,involved
R10729 T20283 T20284 themeOf inducing,lacking
R12212 T22416 T22424 themeOf IL-17,production
R12213 T22417 T22425 themeOf IL-15,response
R12214 T22418 T22425 themeOf MCP-1,response
R12215 T22420 T22427 themeOf IL-17,upregulation
R12216 T22422 T22428 themeOf IL-17,production
R12217 T22423 T22430 themeOf IL-17,introduction
R12218 T22424 T22426 themeOf production,pronounced
R12219 T22428 T22429 themeOf production,regulation
R549 T1353 T1384 causeOf IL-15,upregulated
R550 T1354 T1384 causeOf monocyte chemoattractant protein-1,upregulated
R552 T1356 T1383 themeOf IL-17,production
R553 T1361 T1385 themeOf IL-17,expression
R554 T1363 T1386 themeOf IL-17,production
R555 T1365 T1389 themeOf activator protein-1,inhibition
R557 T1368 T1390 themeOf IL-17,production
R558 T1370 T1392 themeOf IL-17,overproduction
R564 T1381 T1382 themeOf production,increased
R565 T1383 T1384 themeOf production,upregulated
R566 T1383 T1384 themeOf production,upregulated
R567 T1383 T1384 themeOf production,upregulated
R568 T1386 T1387 themeOf production,activated
R569 T1386 T1388 themeOf production,blocked
R570 T1389 T1391 causeOf inhibition,affect
R572 T1390 T1391 themeOf production,affect
R551 T1355 T1384 causeOf IL-6,upregulated
R556 T1366 T1389 themeOf extracellular signal-regulated kinase 1,inhibition
R571 T1389 T1391 causeOf inhibition,affect
R573 T1390 T1391 themeOf production,affect
R1780 T3762 T3795 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1782 T3763 T3795 themeOf interleukin (IL)-1,inhibitors
R1785 T3771 T3796 themeOf IL-17,secreted
R1786 T3772 T3797 themeOf IL-6,induce
R1787 T3773 T3797 themeOf IL-8,induce
R1790 T3777 T3800 causeOf IL-17,activate
R1791 T3778 T3798 themeOf RANKL,induction
R1793 T3780 T3801 themeOf IL-6,production
R1794 T3781 T3801 themeOf leukemia inhibitory factor,production
R1796 T3784 T3803 themeOf IL-15,secreted
R1797 T3785 T3805 themeOf IL-17,production
R1798 T3786 T3808 causeOf IL-23,trigger
R1800 T3787 T3807 themeOf IL-17,production

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Speculation
T1928 40-71 Entity denotes a phosphoinositide 3-kinase/Akt
T1963 10-35 Protein denotes interleukin-17 production
T13249 17281-17331 Regulation denotes inflammatory cytokines released by activated PBMC,
T22605 28494-28519 Gene_expression denotes of IL-17 production in RA
T22604 28479-28519 Regulation denotes the regulation of IL-17 production in RA
T22603 28639-28687 Gene_expression denotes the successful introduction of anti-IL-17 in RA,
T22602 28101-28222 Gene_expression denotes We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation
T22601 28270-28332 Positive_regulation denotes upregulation of IL-17 by activated T cells in patients with RA
T22600 28544-28554 Entity denotes of T cells
T22599 28375-28383 Protein denotes PI3K/Akt
T22598 28593-28608 Protein denotes RA pathogenesis
T22597 28517-28519 Protein denotes RA
T22596 28283-28291 Protein denotes of IL-17
T22595 28684-28686 Protein denotes RA
T22594 28407-28423 Protein denotes NF-κB activation
T22593 28380-28383 Protein denotes Akt
T22592 28147-28155 Protein denotes of IL-17
T22591 28194-28199 Protein denotes MCP-1
T22590 28375-28383 Protein denotes PI3K/Akt
T22589 28793-28795 Protein denotes RA
T22588 28330-28332 Protein denotes RA
T22587 28497-28502 Protein denotes IL-17
T22586 28292-28312 Entity denotes by activated T cells
T22585 28161-28163 Protein denotes RA
T22584 28667-28680 Protein denotes of anti-IL-17
T22583 28161-28168 Entity denotes RA PBMC
T22582 28184-28189 Protein denotes IL-15
T21863 27420-27442 Binding denotes association with NF-κB
T21862 25050-25066 Gene_expression denotes IL-17 production
T21861 26643-26659 Gene_expression denotes IL-17 production
T21860 26263-26374 Positive_regulation denotes the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33] true
T21859 26959-26987 Gene_expression denotes the induction of IL-17 in RA
T21858 26959-26987 Positive_regulation denotes the induction of IL-17 in RA
T21857 23255-23284 Gene_expression denotes IL-17 production from RA PBMC
T21856 26866-26887 Phosphorylation denotes Akt is phosphorylated
T21855 23735-23751 Gene_expression denotes IL-17 production
T21854 25805-25838 Gene_expression denotes anti-CD3-induced IL-17 production
T21853 24795-24811 Gene_expression denotes IL-17 production
T21852 22646-22703 Gene_expression denotes a T cell-derived cytokine with proinflammatory properties
T21851 26784-26798 Positive_regulation denotes Akt activation
T21850 27674-27706 Positive_regulation denotes the upregulation of IL-17 in RA,
T21849 25368-25419 Positive_regulation denotes anti-CD28 also increases IL-17 induction in RA PBMC
T21848 25368-25419 Positive_regulation denotes anti-CD28 also increases IL-17 induction in RA PBMC
T21847 24392-24416 Gene_expression denotes IL-17 production [13,14]
T21846 22746-22762 Gene_expression denotes IL-17 production
T21845 23245-23311 Positive_regulation denotes increased IL-17 production from RA PBMC in a dose-dependent manner
T21844 26207-26257 Positive_regulation denotes In myocytes, IκB kinase-β is activated by p38 [32]
T21843 24629-24745 Positive_regulation denotes demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
T21842 24629-24745 Positive_regulation denotes demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
T21841 22985-23008 Gene_expression denotes IL-17 production in RA,
T21840 26013-26085 Positive_regulation denotes that anti-CD3-induced IL-17 production was downregulated by the addition
T21839 27886-27976 Gene_expression denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21838 27886-27976 Positive_regulation denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21837 27167-27203 Positive_regulation denotes in the induction of IL-17 in RA PBMC
T21836 27167-27203 Gene_expression denotes in the induction of IL-17 in RA PBMC
T21835 26018-26051 Gene_expression denotes anti-CD3-induced IL-17 production
T21834 24560-24582 Localization denotes T cell receptor (TCR)
T21833 23039-23055 Gene_expression denotes IL-17 production
T21832 26893-26913 Positive_regulation denotes anti-CD3 stimulation
T21831 22299-22328 Gene_expression denotes the T cell-derived cytokines,
T21830 25576-25639 Regulation denotes IL-17 production can be regulated by certain signaling pathways
T21829 23224-23243 Localization denotes the T cell receptor
T21828 27611-27637 Positive_regulation denotes resultant NF-κB activation
T21827 23486-23536 Gene_expression denotes IL-17 is produced mainly by activated CD4+ T cells
T21826 27524-27549 Positive_regulation denotes the signal inducing IL-17
T21825 27524-27549 Gene_expression denotes the signal inducing IL-17
T21824 24457-24487 Gene_expression denotes production of IL-17 in RA PBMC
T21823 26402-26451 Regulation denotes p38 MAPK activation was not affected by LY294002,
T21822 25393-25419 Gene_expression denotes IL-17 induction in RA PBMC
T21821 25393-25419 Positive_regulation denotes IL-17 induction in RA PBMC
T21820 25748-25773 Gene_expression denotes in the induction of IL-17
T21819 25748-25773 Positive_regulation denotes in the induction of IL-17
T21818 24331-24416 Regulation denotes some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]
T21817 24711-24745 Gene_expression denotes the production of IL-17 in RA PBMC
T21816 24298-24321 Gene_expression denotes IL-17 production in RA,
T21815 26263-26280 Positive_regulation denotes the activated p38
T21814 25999-26085 Negative_regulation denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition
T21813 26573-26591 Positive_regulation denotes of PI3K activation
T21812 23376-23402 Positive_regulation denotes this upregulation of IL-17
T21811 22521-22548 Gene_expression denotes of T cell-derived cytokines
T21810 24956-24972 Gene_expression denotes IL-17 production
T21809 25456-25502 Gene_expression denotes the induction of cytokines/chemokines by IL-17
T21808 25456-25502 Positive_regulation denotes the induction of cytokines/chemokines by IL-17
T21807 25576-25592 Gene_expression denotes IL-17 production
T21806 26742-26746 Protein denotes PI3K
T21805 26344-26369 Protein denotes p300/CREB-binding protein
T21804 24657-24686 Protein denotes MCP-1 as well as TCR ligation
T21803 24347-24352 Protein denotes IL-15
T21802 26202-26205 Protein denotes p38
T21801 27598-27606 Protein denotes PI3K/Akt
T21800 23514-23536 Entity denotes activated CD4+ T cells
T21799 23138-23191 Protein denotes our experiments, PHA as mitogens, as well as anti-CD3
T21798 22646-22703 Protein denotes a T cell-derived cytokine with proinflammatory properties
T21797 25277-25281 Entity denotes PBMC
T21796 26973-26981 Protein denotes of IL-17
T21795 27009-27019 Protein denotes that NF-κB
T21794 26192-26197 Protein denotes NF-κB
T21793 26035-26040 Protein denotes IL-17
T21792 24298-24303 Protein denotes IL-17
T21791 26402-26421 Protein denotes p38 MAPK activation
T21790 26101-26104 Protein denotes p38
T21789 26246-26257 Protein denotes by p38 [32]
T21788 27802-27807 Protein denotes IL-17
T21787 24357-24362 Protein denotes IL-23
T21786 27196-27203 Entity denotes RA PBMC
T21785 22835-22840 Protein denotes IL-17
T21784 22648-22662 Entity denotes T cell-derived
T21783 27621-27626 Protein denotes NF-κB
T21782 24515-24535 Protein denotes cytokines/chemokines
T21781 22985-22990 Protein denotes IL-17
T21780 27544-27549 Protein denotes IL-17
T21779 25842-25844 Protein denotes RA
T21778 22404-22406 Protein denotes RA
T21777 23394-23402 Protein denotes of IL-17
T21776 25080-25085 Protein denotes TNF-α
T21775 22248-22253 Protein denotes TNF-α
T21774 24606-24615 Protein denotes anti-CD28
T21773 23183-23191 Protein denotes anti-CD3
T21772 27051-27060 Protein denotes anti-CD28
T21771 24111-24128 Protein denotes cytokines such as
T21770 24647-24652 Protein denotes IL-15
T21769 22128-22149 Entity denotes synovial lining cells
T21768 24540-24605 Entity denotes mitogens as well as T cell receptor (TCR) ligation using anti-CD3
T21767 23912-23914 Protein denotes RA
T21766 23486-23491 Protein denotes IL-17
T21765 24577-24580 Protein denotes TCR
T21764 26898-26901 Protein denotes CD3
T21763 22524-22538 Entity denotes T cell-derived
T21762 26101-26119 Entity denotes p38 MAPK inhibitor
T21761 25393-25398 Protein denotes IL-17
T21760 25884-25888 Protein denotes PI3K
T21759 27432-27442 Protein denotes with NF-κB
T21758 22521-22548 Protein denotes of T cell-derived cytokines
T21757 24195-24225 Entity denotes prostaglandin E2 in vitro [12,
T21756 22779-22786 Entity denotes RA PBMC
T21755 26542-26591 Protein denotes a p38 MAPK pathway independent of PI3K activation
T21754 27306-27316 Protein denotes chemokines
T21753 24051-24056 Protein denotes IL-17
T21752 22431-22438 Entity denotes T cells
T21751 27382-27386 Protein denotes PI3K
T21750 25134-25144 Protein denotes that MCP-1
T21749 27391-27416 Protein denotes its downstream kinase Akt
T21748 25483-25493 Protein denotes chemokines
T21747 23808-23819 Entity denotes II collagen
T21746 24468-24476 Protein denotes of IL-17
T21745 23228-23234 Entity denotes T cell
T21744 23039-23044 Protein denotes IL-17
T21743 24763-24768 Protein denotes MCP-1
T21742 23162-23171 Entity denotes mitogens,
T21741 24392-24397 Protein denotes IL-17
T21740 26497-26509 Entity denotes by LY294002,
T21739 27123-27140 Protein denotes the NF-κB pathway
T21738 23886-23921 Entity denotes between cells in inflamed RA joints
T21737 24840-24844 Protein denotes IL-1
T21736 27495-27510 Entity denotes many cell types
T21735 26344-26369 Protein denotes p300/CREB-binding protein
T21734 25473-25493 Protein denotes cytokines/chemokines
T21733 23277-23284 Entity denotes RA PBMC
T21732 23825-23841 Entity denotes collagen-induced
T21731 24738-24740 Protein denotes RA
T21730 26295-26374 Protein denotes NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]
T21729 25412-25419 Entity denotes RA PBMC
T21728 24480-24482 Protein denotes RA
T21727 26101-26119 Protein denotes p38 MAPK inhibitor
T21726 25880-25907 Entity denotes the PI3K inhibitor LY294002
T21725 24726-24734 Protein denotes of IL-17
T21724 24011-24022 Entity denotes other cells
T21723 24560-24581 Protein denotes T cell receptor (TCR)
T21722 24849-24854 Protein denotes TNF-α
T21721 24480-24487 Entity denotes RA PBMC
T21720 24144-24225 Protein denotes tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,
T21719 27691-27699 Protein denotes of IL-17
T21718 24079-24091 Entity denotes synoviocytes
T21717 22340-22344 Protein denotes IL-4
T21716 27603-27606 Protein denotes Akt
T21715 26542-26591 Protein denotes a p38 MAPK pathway independent of PI3K activation
T21714 22894-22896 Entity denotes OA
T21713 25050-25055 Protein denotes IL-17
T21712 27071-27079 Entity denotes mitogens
T21711 24795-24800 Protein denotes IL-17
T21710 23553-23567 Entity denotes Th1/Th0 cells,
T21709 24515-24535 Protein denotes cytokines/chemokines
T21708 27218-27317 Protein denotes the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines,
T21707 24738-24745 Entity denotes RA PBMC
T21706 22004-22009 Protein denotes IL-17
T21705 23965-23974 Protein denotes cytokines
T21704 22318-22328 Protein denotes cytokines,
T21703 27798-27816 Entity denotes the IL-17 promoter
T21702 25650-25681 Entity denotes signal transduction inhibitors,
T21701 23255-23260 Protein denotes IL-17
T21700 26018-26034 Protein denotes anti-CD3-induced
T21699 22594-22599 Protein denotes IL-17
T21698 23979-23990 Protein denotes chemokines,
T21697 22035-22041 Entity denotes T cell
T21696 23224-23243 Protein denotes the T cell receptor
T21695 27196-27198 Protein denotes RA
T21694 26349-26369 Protein denotes CREB-binding protein
T21693 23192-23244 Protein denotes anti-CD28 for signaling through the T cell receptor,
T21692 25359-25367 Protein denotes anti-CD3
T21691 26326-26333 Entity denotes histone
T21690 24331-24363 Protein denotes some cytokines (IL-15 and IL-23)
T21689 26220-26232 Protein denotes IκB kinase-β
T21688 22868-22870 Protein denotes RA
T21687 24560-24566 Entity denotes T cell
T21686 26402-26405 Protein denotes p38
T21685 23652-23657 Protein denotes IL-23
T21684 27829-27837 Entity denotes LY294002
T21683 25765-25773 Protein denotes of IL-17
T21682 24135-24139 Protein denotes IL-8
T21681 26643-26648 Protein denotes IL-17
T21680 25494-25502 Protein denotes by IL-17
T21679 26576-26580 Protein denotes PI3K
T21678 22779-22781 Protein denotes RA
T21677 25473-25493 Protein denotes cytokines/chemokines
T21676 27024-27050 Protein denotes also activated by anti-CD3
T21675 24318-24320 Protein denotes RA
T21674 26866-26869 Protein denotes Akt
T21673 25020-25030 Protein denotes that IL-15
T21672 27256-27316 Protein denotes another important signaling pathway for cytokines/chemokines
T21671 24195-24208 Entity denotes prostaglandin
T21670 27391-27416 Protein denotes its downstream kinase Akt
T21669 24525-24535 Protein denotes chemokines
T21668 25880-25907 Entity denotes the PI3K inhibitor LY294002
T21667 26326-26374 Protein denotes histone acetylase p300/CREB-binding protein [33]
T21666 25822-25827 Protein denotes IL-17
T21665 26948-26955 Protein denotes of PI3K
T21664 25218-25225 Entity denotes T cells
T21663 27598-27606 Protein denotes PI3K/Akt
T21662 24930-24932 Protein denotes RA
T21661 26439-26451 Entity denotes by LY294002,
T21660 24129-24133 Protein denotes IL-6
T21659 27391-27416 Protein denotes its downstream kinase Akt
T21658 22299-22309 Entity denotes the T cell
T21657 25368-25377 Protein denotes anti-CD28
T21656 26985-26987 Protein denotes RA
T21655 25777-25779 Protein denotes RA
T21654 24674-24677 Protein denotes TCR
T21653 25576-25581 Protein denotes IL-17
T21652 25842-25849 Entity denotes RA PBMC
T21645 26263-26280 Protein denotes the activated p38
T21644 23629-23644 Entity denotes by CD8+ T cells
T21643 24754-24759 Protein denotes IL-15
T21642 23005-23007 Protein denotes RA
T21641 24597-24605 Protein denotes anti-CD3
T21640 22746-22751 Protein denotes IL-17
T21639 25912-25931 Entity denotes the NF-κB inhibitor
T21638 26784-26787 Protein denotes Akt
T21637 23864-23948 Entity denotes A complex interaction between cells in inflamed RA joints might produce a variety of
T21636 23735-23740 Protein denotes IL-17
T21635 22205-22238 Protein denotes Proinflammatory cytokines such as
T21634 27996-28001 Protein denotes IL-17
T21633 26633-26638 Protein denotes NF-κB
T21632 25070-25074 Entity denotes PBMC
T21631 25249-25290 Entity denotes of monocytes/macrophages in PBMC cultures
T21630 23277-23279 Protein denotes RA
T21629 24772-24775 Protein denotes TCR
T21628 22090-22092 Protein denotes RA
T21627 25777-25784 Entity denotes RA PBMC
T21626 22178-22203 Entity denotes by mononuclear cells [23]
T21625 27703-27705 Protein denotes RA
T21624 23808-23819 Entity denotes II collagen
T21623 26625-26628 Protein denotes p38
T21622 26210-26218 Entity denotes myocytes
T21621 27907-27920 Protein denotes of anti-IL-17
T21620 25412-25414 Protein denotes RA
T21619 23783-23790 Entity denotes T cells
T21618 27062-27067 Protein denotes IL-15
T21651 27184-27192 Protein denotes of IL-17
T21650 28084-28086 Protein denotes RA
T21649 22205-22243 Protein denotes Proinflammatory cytokines such as IL-1
T21648 22349-22362 Entity denotes interferon-γ,
T21647 24956-24961 Protein denotes IL-17
T21646 23557-23560 Entity denotes Th0
T16780 21307-21350 Positive_regulation denotes NF-κB activation by anti-CD3 plus anti-CD28
T16779 21307-21350 Positive_regulation denotes NF-κB activation by anti-CD3 plus anti-CD28
T16778 21934-21990 Gene_expression denotes IL-17 production by activated PBMC from patients with RA
T16777 21679-21702 Protein_catabolism denotes of degradation of IκB-α
T16776 20557-20611 Positive_regulation denotes Activation of the NF-κB and activator protein-1 (AP-1)
T16775 20557-20611 Positive_regulation denotes Activation of the NF-κB and activator protein-1 (AP-1)
T16774 21661-21714 Negative_regulation denotes showed inhibition of degradation of IκB-α by LY294002
T16773 20806-20823 Gene_expression denotes IL-17 expression,
T16772 21051-21096 Positive_regulation denotes increased binding of NF-κB to IL-17 promoters
T16771 20959-21096 Binding denotes nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters
T16770 21081-21086 Protein denotes IL-17
T16769 21608-21613 Protein denotes IL-17
T16768 20887-20892 Protein denotes NF-κB
T16767 21604-21632 Entity denotes the IL-17 promoter (Fig. 7c)
T16766 20770-20775 Protein denotes IL-15
T16765 20887-20910 Entity denotes NF-κB recognition sites
T16764 20806-20811 Protein denotes IL-17
T15436 20458-20467 Protein denotes anti-CD3,
T15435 19833-19841 Entity denotes effector
T15434 20273-20295 Protein denotes non-phosphorylated Akt
T15433 19855-19871 Protein denotes the PI3K pathway
T15432 20036-20069 Protein denotes the amounts of phosphorylated Akt
T15431 19737-19808 Protein denotes of PI3K/Akt signal transduction pathway on IL-17 production by anti-CD3
T15430 20358-20361 Protein denotes PHA
T15429 19901-19907 Protein denotes of Akt
T15428 20001-20009 Entity denotes LY294002
T15427 20136-20159 Protein denotes Akt increased (lane 2),
T15426 19797-19808 Protein denotes by anti-CD3
T15425 20189-20209 Entity denotes by LY294002 (lane 3)
T14695 19334-19366 Gene_expression denotes IL-17 mRNA expression in RA PBMC
T14694 19382-19407 Positive_regulation denotes enhanced IL-17 production
T14693 19382-19453 Regulation denotes enhanced IL-17 production could be regulated at a transcriptional level true
T14692 19382-19407 Gene_expression denotes enhanced IL-17 production
T14691 19577-19582 Protein denotes IL-17
T14690 19716-19719 Protein denotes Fig
T14689 19623-19631 Protein denotes anti-CD3
T14688 19655-19682 Entity denotes the PI3K inhibitor LY294002
T14687 19659-19663 Protein denotes PI3K
T14686 19574-19599 Protein denotes in IL-17 mRNA transcripts
T14685 19694-19709 Entity denotes NF-κB inhibitor
T14684 19574-19599 Protein denotes in IL-17 mRNA transcripts
T14683 19334-19344 Protein denotes IL-17 mRNA
T14682 19655-19682 Entity denotes the PI3K inhibitor LY294002
T14681 19359-19361 Protein denotes RA
T14680 19359-19366 Entity denotes RA PBMC
T14679 19334-19339 Protein denotes IL-17
T14678 19391-19396 Protein denotes IL-17
T14369 17903-17967 Negative_regulation denotes Inhibition of IL-17 production by signal transduction inhibitors
T14368 18422-18513 Negative_regulation denotes inhibitor of PI3K, also markedly inhibited the anti-CD3-induced IL-17 production in RA PBMC
T14367 18009-18051 Positive_regulation denotes the increased IL-17 production in RA PBMC,
T14366 18651-18758 Negative_regulation denotes also downregulated the IL-17 secretion as well as the mitogen-activated protein kinase (MAPK) p38 inhibitor
T14365 17914-17933 Gene_expression denotes of IL-17 production
T14364 18989-19031 Negative_regulation denotes the inhibition of IL-17 production in PBMC
T14363 19074-19125 Gene_expression denotes IL-17 production with chemical inhibitors (Fig. 4a)
T14362 18670-18689 Gene_expression denotes the IL-17 secretion
T14361 18148-18226 Negative_regulation denotes . 3, an significant decrease in anti-CD3-induced IL-17 production was observed
T14360 18465-18502 Gene_expression denotes the anti-CD3-induced IL-17 production
T14359 17993-18051 Gene_expression denotes Having observed the increased IL-17 production in RA PBMC,
T14358 18177-18213 Gene_expression denotes in anti-CD3-induced IL-17 production
T14357 19004-19023 Gene_expression denotes of IL-17 production
T14356 18705-18744 Protein denotes mitogen-activated protein kinase (MAPK)
T14355 19249-19272 Entity denotes the chemical inhibitors
T14354 18197-18202 Protein denotes IL-17
T14353 19074-19079 Protein denotes IL-17
T14352 18180-18196 Protein denotes anti-CD3-induced
T14351 19127-19180 Entity denotes The other inhibitors in addition to PDTC and LY294002
T14350 19007-19012 Protein denotes IL-17
T14349 18486-18491 Protein denotes IL-17
T14348 18627-18640 Entity denotes cyclosporin A
T14347 18976-18984 Entity denotes LY294002
T14346 19172-19180 Entity denotes LY294002
T14345 18701-18758 Entity denotes the mitogen-activated protein kinase (MAPK) p38 inhibitor
T14344 18391-18399 Entity denotes LY294002
T14343 18600-18615 Protein denotes The calcineurin
T14342 17934-17967 Entity denotes by signal transduction inhibitors
T14341 18701-18758 Protein denotes the mitogen-activated protein kinase (MAPK) p38 inhibitor
T14340 18674-18679 Protein denotes IL-17
T14339 17972-17992 Entity denotes anti-rheumatic drugs
T14338 18043-18050 Entity denotes RA PBMC
T14337 18276-18289 Entity denotes dexamethasone
T14336 18506-18508 Protein denotes RA
T14335 19241-19245 Entity denotes PBMC
T14334 18469-18485 Protein denotes anti-CD3-induced
T14333 18435-18439 Protein denotes PI3K
T14332 19096-19125 Entity denotes chemical inhibitors (Fig. 4a)
T14331 18898-18909 Entity denotes by the drug
T14330 18404-18414 Entity denotes wortmannin
T14329 18023-18028 Protein denotes IL-17
T14328 18043-18045 Protein denotes RA
T14327 18145-18148 Protein denotes Fig
T14326 19027-19031 Entity denotes PBMC
T14325 18739-18743 Protein denotes MAPK
T14324 18795-18802 Entity denotes PD98059
T14323 18820-18825 Protein denotes IL-17
T14322 18309-18317 Protein denotes anti-CD3
T14321 18250-18266 Entity denotes NF-κB inhibitor,
T14320 17917-17922 Protein denotes IL-17
T14319 18422-18440 Entity denotes inhibitor of PI3K,
T14318 18781-18790 Entity denotes rapamycin
T14317 18874-18886 Entity denotes non-specific
T14316 18506-18513 Entity denotes RA PBMC
T13251 17216-17252 Gene_expression denotes the production of IL-17 from T cells
T13250 17393-17409 Gene_expression denotes IL-17 production
T13248 17138-17195 Regulation denotes cytokines released from macrophages and other lymphocytes
T13247 16981-17011 Gene_expression denotes of IL-17 production in RA PBMC
T13246 16970-17052 Regulation denotes Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
T13245 16970-17052 Regulation denotes Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
T13244 17138-17252 Regulation denotes cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells true
T13243 17061-17063 Protein denotes RA
T13242 17313-17330 Entity denotes by activated PBMC
T13241 17357-17374 Protein denotes several cytokines
T13240 17873-17890 Protein denotes MIP-1β (10 ng/ml)
T13239 17560-17576 Protein denotes TGF-β (10 ng/ml)
T13238 17540-17556 Protein denotes IL-18 (10 ng/ml)
T13237 16984-16989 Protein denotes IL-17
T13236 17077-17095 Entity denotes several cell types
T13235 17835-17851 Protein denotes IL-8 (10 ng/ml),
T13234 17707-17712 Protein denotes IL-17
T13233 17591-17596 Protein denotes IL-17
T13232 17281-17331 Protein denotes inflammatory cytokines released by activated PBMC,
T13231 17042-17052 Protein denotes chemokines
T13230 17111-17119 Entity denotes T cells,
T13229 17178-17195 Entity denotes other lymphocytes
T13228 17162-17173 Entity denotes macrophages
T13227 17138-17195 Protein denotes cytokines released from macrophages and other lymphocytes
T13226 17707-17721 Protein denotes IL-17 proteins
T13225 17015-17037 Protein denotes inflammatory cytokines
T13224 17061-17068 Entity denotes RA PBMC
T13223 17231-17239 Protein denotes of IL-17
T13222 17004-17011 Entity denotes RA PBMC
T13221 17852-17869 Protein denotes MIP-1α (10 ng/ml)
T13220 17473-17478 Protein denotes IL-15
T13219 17641-17657 Protein denotes MCP-1 (10 ng/ml)
T13218 17379-17389 Protein denotes chemokines
T13217 17504-17521 Protein denotes IL-1β (10 ng/ml),
T13216 17004-17006 Protein denotes RA
T13215 17438-17443 Protein denotes IL-17
T13214 17522-17538 Protein denotes TNF-α (10 ng/ml)
T13213 17245-17252 Entity denotes T cells
T13212 17393-17398 Protein denotes IL-17
T13211 17661-17665 Protein denotes IL-6
T12338 16846-16872 Gene_expression denotes increased IL-17 production
T12337 16130-16154 Gene_expression denotes IL-17 production in PBMC
T12336 16635-16657 Gene_expression denotes IL-17 production up to
T12335 16120-16186 Positive_regulation denotes Increased IL-17 production in PBMC of patients with RA by anti-CD3
T12334 16672-16762 Gene_expression denotes the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold)
T12333 16588-16666 Positive_regulation denotes in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold
T12332 16846-16872 Positive_regulation denotes increased IL-17 production
T12331 16463-16468 Protein denotes IL-17
T12330 16817-16845 Protein denotes T cell mitogens such as PHA,
T12329 16291-16308 Entity denotes activated T cells
T12328 16172-16174 Protein denotes RA
T12327 16209-16212 Protein denotes PHA
T12326 16365-16396 Protein denotes of anti-CD3 (1, 5 and 10 μg/ml)
T12325 16763-16776 Protein denotes than anti-CD3
T12324 16705-16713 Protein denotes anti-CD3
T12323 16150-16154 Entity denotes PBMC
T12322 16856-16861 Protein denotes IL-17
T12321 16723-16762 Protein denotes more IL-17 (approximately 1.3-1.5-fold)
T12320 16569-16577 Protein denotes anti-CD3
T12319 16600-16608 Protein denotes anti-CD3
T12318 16221-16226 Protein denotes IL-17
T12317 16903-16911 Protein denotes anti-CD3
T12316 16635-16640 Protein denotes IL-17
T12315 16130-16135 Protein denotes IL-17
T12314 16194-16204 Protein denotes anti-CD28,
T12313 16916-16925 Protein denotes anti-CD28
T12312 16691-16700 Protein denotes anti-CD28
T12311 16817-16840 Entity denotes T cell mitogens such as
T12310 16178-16186 Protein denotes anti-CD3
T12309 16402-16408 Entity denotes T cell
T12308 16817-16823 Entity denotes T cell
T11598 15493-15540 Gene_expression denotes IL-17 production in PBMC from patients with RA,
T11597 15931-15969 Positive_regulation denotes the IL-17 production stimulated by PHA
T11596 15800-15824 Gene_expression denotes of basal IL-17 secretion
T11595 15931-15969 Gene_expression denotes the IL-17 production stimulated by PHA
T11594 15513-15517 Entity denotes PBMC
T11593 15935-15940 Protein denotes IL-17
T11592 15707-15712 Protein denotes IL-17
T11591 15652-15654 Protein denotes RA
T11590 15852-15854 Protein denotes RA
T11589 15619-15632 Protein denotes PHA (5 μg/ml)
T11588 15581-15585 Entity denotes PBMC
T11587 15856-15858 Entity denotes OA
T11586 15493-15498 Protein denotes IL-17
T11585 15809-15814 Protein denotes IL-17
T11584 15670-15672 Entity denotes OA
T11583 15998-16000 Protein denotes RA
T11582 15744-15768 Entity denotes the culture supernatants
T11581 15998-16005 Entity denotes RA PBMC
T11580 16076-16077 Entity denotes P
T11579 15555-15557 Entity denotes OA
T11578 15963-15969 Protein denotes by PHA
T11577 15537-15540 Protein denotes RA,
T11576 15770-15773 Protein denotes Fig
T11575 16106-16107 Entity denotes P
T11574 16025-16027 Entity denotes OA
T11077 15404-15405 Entity denotes t
T10984 15132-15156 Binding denotes the cells were harvested
T10983 14902-14950 Entity denotes Cell viability (Trypan blue dye exclusion assay)
T10982 15237-15252 Entity denotes of viable cells
T10981 15260-15289 Entity denotes of both viable and dead cells
T10980 15050-15099 Entity denotes of direct cytotoxic effect of inhibitors on cells
T10979 14982-14993 Entity denotes trypan blue
T10978 15091-15099 Entity denotes on cells
T10977 15077-15090 Entity denotes of inhibitors
T10976 15132-15141 Entity denotes the cells
T10975 14918-14929 Entity denotes Trypan blue
T10974 14955-14959 Entity denotes cell
T10745 13801-13818 Localization denotes Nuclear proteins
T10744 13801-13856 Negative_regulation denotes Nuclear proteins were extracted from about 5 × 106 PBMC
T10743 14116-14142 Entity denotes Unincorporated nucleotides
T10742 14474-14483 Entity denotes glycerol,
T10741 14497-14513 Entity denotes 0.2% Nonidet P40
T10740 14159-14172 Protein denotes NucTrap probe
T10739 14631-14654 Entity denotes Tris-borate-EDTA buffer
T10738 14000-14009 Protein denotes by 5'-end
T10737 14081-14114 Protein denotes T4 polynucleotide kinase (TaKaRa)
T10736 13973-13976 Entity denotes AAA
T10735 13946-13982 Protein denotes 5'-ATG ACC TGG AAA TAC CCA AAA TTC-3
T10734 14227-14243 Entity denotes Nuclear extracts
T10733 14599-14621 Entity denotes 5% polyacrylamide gels
T10732 14402-14417 Entity denotes 20 mM Tris-HCl,
T10731 14772-14800 Entity denotes Rabbit polyclonal antibodies
T10730 14437-14470 Entity denotes 1 mM dithiothreitol, 0.5 mM EDTA,
T10729 14602-14616 Entity denotes polyacrylamide
T10728 13930-13935 Protein denotes IL-17
T10727 14458-14469 Entity denotes 0.5 mM EDTA
T10726 14295-14298 Entity denotes DNA
T10725 13961-13964 Entity denotes AAA
T10724 14486-14496 Protein denotes mg/ml BSA,
T10723 14159-14162 Entity denotes Nuc
T10722 13801-13817 Protein denotes Nuclear proteins
T10721 13917-13944 Entity denotes of the human IL-17 promoter
T10720 13833-13856 Entity denotes from about 5 × 106 PBMC
T10719 13754-13800 Entity denotes Gel mobility-shift assay of NF-κB binding site
T10718 14809-14814 Protein denotes NF-κB
T10717 14307-14328 Protein denotes 10 ng; 100,000 c.p.m.
T10716 13965-13968 Protein denotes TAC
T10715 13946-13982 Protein denotes 5'-ATG ACC TGG AAA TAC CCA AAA TTC-3
T10714 14426-14435 Entity denotes 50 mM KCl
T10713 14081-14083 Entity denotes T4
T10712 14402-14417 Entity denotes 20 mM Tris-HCl,
T10711 14837-14842 Protein denotes c-Rel
T10710 13779-13800 Entity denotes of NF-κB binding site
T10709 13858-13873 Entity denotes Oligonucleotide
T10708 13801-13817 Entity denotes Nuclear proteins
T10707 14674-14678 Entity denotes Gels
T10706 14829-14832 Protein denotes p65
T10705 14809-14827 Protein denotes NF-κB subunits p50
T10704 14051-14076 Entity denotes dATP (Amersham Pharmacia)
T10703 13946-13982 Protein denotes 5'-ATG ACC TGG AAA TAC CCA AAA TTC-3
T10702 14253-14260 Protein denotes protein
T9959 12496-12554 Phosphorylation denotes Western blot analysis of Akt, phosphorylated Akt and IκB-α
T9958 12496-12554 Phosphorylation denotes Western blot analysis of Akt, phosphorylated Akt and IκB-α
T9957 13685-13688 Protein denotes ECL
T9956 12555-12559 Entity denotes PBMC
T9955 12549-12554 Protein denotes IκB-α
T9954 13106-13114 Entity denotes membrane
T9953 13189-13202 Entity denotes Tris-buffered
T9952 13508-13528 Entity denotes secondary antibodies
T9951 12627-12646 Entity denotes of LY294002 (20 μM)
T9950 12852-12868 Entity denotes the supernatants
T9949 12541-12544 Protein denotes Akt
T9948 13602-13627 Entity denotes TBS-T washing, hybridized
T9947 12580-12599 Protein denotes anti-CD3 (10 μg/ml)
T9946 12940-12955 Entity denotes Protein samples
T9945 12715-12730 Entity denotes about 107 cells
T9944 13189-13209 Entity denotes Tris-buffered saline
T9943 13304-13309 Protein denotes IκB-α
T9942 13276-13279 Protein denotes Akt
T9941 13380-13393 Entity denotes 5% BSA/TBS-T,
T9940 13311-13315 Entity denotes Cell
T9939 13467-13473 Entity denotes TBS-T,
T9938 13158-13163 Entity denotes TBS-T
T9937 13244-13279 Entity denotes then primary antibodies against Akt
T9936 12518-12525 Protein denotes of Akt,
T9935 13296-13299 Protein denotes Akt
T9934 13352-13361 Protein denotes MA, USA),
T9933 12826-12868 Entity denotes Protein concentrations in the supernatants
T9932 13708-13751 Entity denotes Hyperfilm-ECL reagents (Amersham Pharmacia)
T9130 11924-11954 Protein denotes 5'-CGA TGC TGG GCG TGA GTA C-3
T9129 11868-11916 Protein denotes glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
T9128 11303-11316 Protein denotes of total mRNA
T9127 11792-11795 Entity denotes AAG
T9126 11974-12003 Protein denotes 5'-CGT TCA GCT CAG GGA TGA CC
T9125 12186-12192 Protein denotes IL-17,
T9124 11836-11843 Protein denotes GGC CAC
T9123 11852-11863 Protein denotes GAC AAT CGG
T9122 11957-11972 Protein denotes GAPDH antisense
T9121 11836-11839 Protein denotes GGC
T9120 11760-11765 Protein denotes IL-17
T9119 11844-11851 Entity denotes ATG GTG
T9118 11497-11515 Protein denotes Taq DNA polymerase
T9117 11481-11485 Entity denotes dNTP
T9116 11739-11748 Entity denotes molecules
T9115 12454-12474 Protein denotes of IL-17 PCR product
T9114 11599-11602 Protein denotes PCR
T9113 11636-11659 Entity denotes 10 mM Tris-HCl, pH 8.3)
T9112 12297-12302 Protein denotes IL-17
T9111 11931-11934 Protein denotes TGC
T9110 12413-12417 Protein denotes mRNA
T9109 11926-11930 Protein denotes -CGA
T9166 12413-12428 Gene_expression denotes mRNA expression
T9165 12413-12428 Transcription denotes mRNA expression
T9164 11148-11166 Negative_regulation denotes mRNA was extracted
T9163 12480-12493 Entity denotes GAPDH product
T9162 11780-11783 Protein denotes ACT
T9161 11788-11807 Entity denotes GGG AAG ACC TCA TTG
T9160 12287-12292 Protein denotes GAPDH
T9159 11974-12003 Entity denotes 5'-CGT TCA GCT CAG GGA TGA CC
T9158 10999-11003 Entity denotes PBMC
T9157 12385-12398 Entity denotes each molecule
T9156 11974-12003 Protein denotes 5'-CGT TCA GCT CAG GGA TGA CC
T9155 11101-11110 Entity denotes LY294002,
T9154 12176-12181 Protein denotes GAPDH
T9153 11492-11515 Entity denotes U of Taq DNA polymerase
T9152 11203-11220 Protein denotes Houston, TX, USA)
T9151 11086-11116 Entity denotes of inhibitors (LY294002, PDTC)
T9150 11939-11942 Protein denotes GCG
T9149 11636-11659 Entity denotes 10 mM Tris-HCl, pH 8.3)
T9148 11910-11915 Protein denotes GAPDH
T9147 12480-12485 Protein denotes GAPDH
T9146 11773-11787 Entity denotes 5'-ATG ACT CCT
T9145 11148-11152 Protein denotes mRNA
T9144 11618-11635 Entity denotes MgCl2, 50 mM KCl,
T9143 11625-11634 Entity denotes 50 mM KCl
T9142 11808-11817 Protein denotes 3'; IL-17
T9141 11298-11316 Protein denotes 2 μg of total mRNA
T9140 11497-11500 Protein denotes Taq
T9139 12457-12462 Protein denotes IL-17
T9138 11415-11418 Protein denotes PCR
T9137 12234-12237 Protein denotes PCR
T9136 12078-12095 Protein denotes Norwalk, CT, USA)
T9135 11047-11058 Protein denotes of anti-CD3
T9134 12038-12041 Entity denotes DNA
T9133 11788-11807 Protein denotes GGG AAG ACC TCA TTG
T9132 10920-10925 Protein denotes IL-17
T9131 10917-10930 Protein denotes of IL-17 mRNA
T8152 10076-10161 Protein_modification denotes with 500 ng/ml biotinylated mouse monoclonal antibodies against IL-17 (R & D Systems)
T8151 10416-10421 Protein denotes Sigma
T8150 9780-9783 Protein denotes BSA
T8149 9626-9660 Protein denotes with 4 μg/ml monoclonal antibodies
T8148 10210-10264 Protein denotes streptavidin–alkaline phosphate–horseradish peroxidase
T8147 10369-10386 Entity denotes phosphate (Sigma)
T8146 10613-10662 Protein denotes Recombinant human IL-17 diluted in culture medium
T8145 9669-9690 Protein denotes IL-17 (R & D Systems)
T8144 10140-10161 Protein denotes IL-17 (R & D Systems)
T8143 9756-9784 Protein denotes % bovine serum albumin (BSA)
T8142 10495-10506 Entity denotes of 1 M NaOH
T8141 9729-9738 Entity denotes phosphate
T8140 10276-10281 Protein denotes Sigma
T8139 9420-9433 Protein denotes Enzyme-linked
T8138 10400-10422 Entity denotes diethanolamine (Sigma)
T8137 9860-9890 Protein denotes the standard recombinant IL-17
T8136 10583-10588 Protein denotes IL-17
T8135 9454-9462 Protein denotes of IL-17
T8134 10878-10883 Protein denotes IL-17
T8133 10380-10385 Protein denotes Sigma
T8132 10265-10282 Entity denotes conjugate (Sigma)
T8131 9472-9492 Entity denotes culture supernatants
T8130 9463-9492 Protein denotes IL-17 in culture supernatants
T8129 10822-10846 Protein denotes of recombinant cytokines
T8128 10352-10422 Entity denotes ml p-nitrophenyl phosphate (Sigma) dissolved in diethanolamine (Sigma)
T8127 10104-10131 Protein denotes mouse monoclonal antibodies
T8126 9784-9842 Entity denotes /0.05% Tween 20 for 2 hours at room temperature (22–25°C),
T8125 10021-10039 Entity denotes phosphate-buffered
T7218 9052-9138 Binding denotes CD4–phycoerythrin were washed, magnetically labeled with anti-phycoerythrin microbeads
T7217 9028-9051 Entity denotes cells stained with anti
T7216 8823-8827 Protein denotes MACS
T7215 8446-8450 Entity denotes PBMC
T7214 9056-9069 Protein denotes phycoerythrin
T7213 9309-9322 Entity denotes stained cells
T7212 8821-8837 Protein denotes a MACS MS column
T7211 8688-8728 Protein denotes 2.5 ml of FBS staining buffer, pelleted,
T7210 9052-9069 Protein denotes CD4–phycoerythrin
T7209 9328-9332 Protein denotes FACS
T7208 8666-8671 Entity denotes Cells
T7207 8344-8351 Protein denotes by MACS
T7206 9052-9069 Protein denotes CD4–phycoerythrin
T7205 9396-9417 Entity denotes the CD4 T cell marker
T7204 9400-9403 Protein denotes CD4
T7203 8480-8483 Protein denotes FBS
T7202 8501-8528 Protein denotes Anti-CD4 microbeads (20 μl)
T7201 9256-9264 Entity denotes of cells
T7200 8327-8333 Entity denotes T-cell
T7199 8352-8444 Protein denotes Anti-CD4 microbeads were used essentially as recommended by the manufacturer (Miltenyi) [19]
T7198 8695-8728 Protein denotes of FBS staining buffer, pelleted,
T7197 9373-9391 Entity denotes the isolated cells
T7196 8595-8632 Entity denotes of fluorochrome-conjugated antibodies
T7195 9161-9168 Entity denotes of cell
T7194 9169-9183 Entity denotes suspension; 15
T7193 8913-8927 Entity denotes Enriched cells
T6515 7314-7340 Positive_regulation denotes T cell receptor activation
T6514 7689-7704 Entity denotes ml streptomycin
T6513 7302-7310 Protein denotes of IL-17
T6512 8058-8076 Entity denotes LY294002, SB203580
T6511 7314-7340 Entity denotes T cell receptor activation
T6510 8031-8040 Entity denotes rapamycin
T6509 7966-7971 Entity denotes cells
T6508 7727-7749 Entity denotes Cell suspension (1 ml)
T6507 7709-7725 Entity denotes 2 mM L-glutamine
T6506 7727-7749 Entity denotes Cell suspension (1 ml)
T6505 8042-8050 Entity denotes curcumin
T6504 7537-7557 Entity denotes the cell suspensions
T6503 8173-8182 Entity denotes cell-free
T6502 8087-8100 Entity denotes dexamethasone
T6501 8104-8114 Entity denotes wortmannin
T6500 8078-8085 Entity denotes PD98059
T6499 8058-8067 Entity denotes LY294002,
T6498 7355-7365 Protein denotes chemokines
T6497 8018-8030 Entity denotes added FK506,
T6496 7665-7688 Entity denotes U/ml penicillin, 100 mg
T6495 7366-7370 Entity denotes PBMC
T6494 7321-7329 Protein denotes receptor
T6493 7537-7557 Entity denotes the cell suspensions
T6492 7342-7351 Protein denotes cytokines
T6491 7905-7921 Entity denotes of cyclosporin A
T5879 6755-6813 Binding denotes Recombinant TNF-α and IL-1 were purchased from Endogen Inc
T5878 6457-6465 Entity denotes Reagents
T5877 6602-6606 Protein denotes IL-8
T5876 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5875 7197-7205 Entity denotes SB203580
T5874 6485-6490 Protein denotes IL-18
T5873 6901-6925 Protein denotes Phytohemagglutinin (PHA)
T5872 7207-7224 Entity denotes FK506, wortmannin
T5871 6837-6850 Entity denotes Cyclosporin A
T5870 6974-6987 Entity denotes dexamethasone
T5869 7166-7169 Protein denotes San
T5868 6927-6961 Entity denotes pyrrolidine dithiocarbamate (PDTC)
T5867 6992-7000 Entity denotes curcumin
T5866 7106-7110 Protein denotes CD28
T5865 7028-7033 Protein denotes Sigma
T5864 7229-7236 Entity denotes PD98059
T5863 7187-7206 Entity denotes LY294002, SB203580,
T5862 6855-6877 Entity denotes provided by Sandos Ltd
T5861 6535-6540 Protein denotes MCP-1
T5860 7207-7212 Entity denotes FK506
T5859 6777-6781 Protein denotes IL-1
T5858 6585-6591 Protein denotes MIP-1β
T5857 6921-6924 Protein denotes PHA
T5856 6755-6772 Protein denotes Recombinant TNF-α
T5855 6665-6709 Protein denotes Recombinant transforming growth factor (TGF)
T5854 6593-6597 Protein denotes IL-6
T5853 7058-7061 Entity denotes MA,
T5852 6466-6606 Protein denotes Recombinant IL-17, IL-18, IL-15, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β, IL-6 and IL-8
T5851 6816-6835 Entity denotes Cambridge, MA, USA)
T5850 6478-6491 Protein denotes IL-17, IL-18,
T5849 6963-6972 Entity denotes rapamycin
T5848 7101-7130 Protein denotes anti-CD28 monoclonal antibody
T5847 6499-6541 Protein denotes monocyte chemoattractant protein-1 (MCP-1)
T5846 6742-6752 Protein denotes London, UK
T4513 4720-4725 Protein denotes IL-17
T4512 2965-2972 Entity denotes T cells
T4511 4628-4670 Protein denotes IL-15, secreted from activated macrophages
T4510 3807-3830 Protein denotes IL-8 by fibroblasts [5]
T4509 3058-3085 Entity denotes the largest cell population
T4508 5261-5265 Entity denotes PBMC
T4507 5041-5043 Protein denotes RA
T4506 5476-5517 Protein denotes the key inflammatory cytokine IL-17 in RA
T4505 3560-3571 Entity denotes II collagen
T4504 3644-3654 Entity denotes of T cells
T4503 3713-3742 Protein denotes of the inflammatory cytokines
T4502 3250-3260 Entity denotes macrophage
T4501 3325-3330 Protein denotes TNF-α
T4500 3440-3446 Protein denotes RA [3]
T4499 3208-3241 Protein denotes interferon-γ in the joints of RA,
T4498 3406-3416 Entity denotes of T cells
T4497 4415-4441 Entity denotes the dendritic cells [8-10]
T4496 4740-4742 Protein denotes RA
T5208 6222-6224 Entity denotes OA
T5207 5761-5836 Entity denotes fulfilled the 1987 revised criteria of the American College of Rheumatology
T5206 5754-5756 Protein denotes RA
T5205 6082-6105 Entity denotes OA (3 men and 11 women)
T5204 5973-5988 Entity denotes All medications
T5203 5919-5921 Protein denotes RA
T4601 4217-4363 Positive_regulation denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4600 4217-4363 Positive_regulation denotes It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4599 4236-4363 Gene_expression denotes the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4598 4236-4363 Gene_expression denotes the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes
T4597 3041-3111 Binding denotes because they are the largest cell population infiltrating the synovium
T4596 4091-4171 Gene_expression denotes the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),
T4595 4091-4171 Positive_regulation denotes the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),
T4594 3208-3241 Localization denotes interferon-γ in the joints of RA,
T4593 3250-3331 Localization denotes macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α
T4592 2565-2600 Regulation denotes cytokines released from these cells
T4591 3166-3198 Gene_expression denotes T cell-derived cytokines such as
T4590 4628-4670 Gene_expression denotes IL-15, secreted from activated macrophages
T4589 4923-4952 Gene_expression denotes of IL-17 production from both
T4588 4717-4736 Gene_expression denotes of IL-17 production
T4587 5229-5324 Gene_expression denotes investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway
T4586 5145-5161 Gene_expression denotes IL-17 production
T4585 3627-3634 Protein denotes RA [4],
T4584 5644-5646 Protein denotes RA
T4583 3815-3830 Entity denotes fibroblasts [5]
T4582 2499-2506 Entity denotes T cells
T4581 2713-2756 Entity denotes inhibitors of tumor necrosis factor (TNF)-α
T4580 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T4579 3709-3742 Protein denotes one of the inflammatory cytokines
T4578 4649-4670 Entity denotes activated macrophages
T4577 4335-4363 Entity denotes nitric oxide by chondrocytes
T4576 3832-3845 Protein denotes This cytokine
T4575 4351-4363 Entity denotes chondrocytes
T4574 5427-5432 Protein denotes NF-κB
T4573 3315-3320 Protein denotes IL-18
T4572 3302-3306 Protein denotes IL-6
T4571 3296-3300 Protein denotes IL-1
T4570 4805-4822 Entity denotes steroid sensitive
T4569 3512-3539 Entity denotes of antigen specific T cells
T4568 4314-4330 Entity denotes prostaglandin E2
T4567 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T4566 4587-4602 Entity denotes by CD4+ T cells
T4565 4263-4289 Protein denotes leukemia inhibitory factor
T4564 3589-3634 Protein denotes of T helper type 1 (Th1) cytokines in RA [4],
T4563 3798-3802 Protein denotes IL-6
T4562 2996-3025 Protein denotes autoimmune disease such as RA
T4561 4254-4258 Protein denotes IL-6
T4560 4953-4956 Protein denotes CD4
T4559 5585-5587 Protein denotes RA
T4558 2814-2836 Protein denotes inflammatory cytokines
T4557 4962-4979 Entity denotes CD8+ T cells [14]
T4556 3914-3919 Protein denotes IL-1,
T4555 5241-5246 Protein denotes IL-17
T4554 4521-4523 Protein denotes RA
T4553 3515-3522 Entity denotes antigen
T4552 4035-4040 Protein denotes IL-17
T4551 2483-2494 Entity denotes macrophages
T4550 3589-3634 Entity denotes of T helper type 1 (Th1) cytokines in RA [4],
T4549 3308-3313 Protein denotes IL-15
T4548 4926-4931 Protein denotes IL-17
T4547 5283-5285 Protein denotes RA
T4546 3166-3203 Protein denotes T cell-derived cytokines such as IL-2
T4545 3601-3613 Protein denotes type 1 (Th1)
T4544 3560-3571 Entity denotes II collagen
T4543 5344-5357 Entity denotes intracellular
T4542 5007-5015 Protein denotes of IL-17
T4541 5386-5418 Protein denotes phosphoinositide 3-kinase (PI3K)
T4540 3700-3705 Protein denotes IL-17
T4539 4562-4564 Entity denotes OA
T4538 3166-3198 Protein denotes T cell-derived cytokines such as
T4537 2589-2600 Entity denotes these cells
T4536 3235-3240 Protein denotes of RA
T4535 5413-5417 Protein denotes PI3K
T4534 3265-3275 Entity denotes fibroblast
T4533 3250-3330 Protein denotes macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α
T4532 3981-3995 Entity denotes by T cells [6]
T4531 3166-3180 Entity denotes T cell-derived
T4530 4209-4215 Protein denotes RA [7]
T4529 5145-5150 Protein denotes IL-17
T4528 3904-3909 Protein denotes TNF-α
T4527 2565-2600 Protein denotes cytokines released from these cells
T4526 4740-4784 Entity denotes RA peripheral blood mononuclear cells (PBMC)
T4525 2762-2780 Protein denotes interleukin (IL)-1
T4524 4105-4113 Protein denotes of RANKL
T4523 4453-4458 Protein denotes IL-17
T4522 4779-4783 Entity denotes PBMC
T4521 2659-2661 Protein denotes RA
T4520 4293-4306 Entity denotes synoviocytes,
T4519 4314-4327 Entity denotes prostaglandin
T4518 2442-2444 Protein denotes RA
T4517 5476-5517 Protein denotes the key inflammatory cytokine IL-17 in RA
T4516 5515-5517 Protein denotes RA
T4515 4887-4892 Protein denotes IL-23
T4514 3920-3925 Protein denotes IL-17
T1984 2219-2235 Gene_expression denotes IL-17 production
T1983 1494-1510 Gene_expression denotes IL-17 production
T1982 666-733 Regulation denotes the intracellular signaling pathways that regulate IL-17 production
T1981 648-664 Gene_expression denotes IL-17 production
T1980 1254-1277 Gene_expression denotes The production of IL-17
T1979 717-733 Gene_expression denotes IL-17 production
T1978 852-892 Regulation denotes the regulation of IL-17 production in RA
T1977 1912-1949 Gene_expression denotes IL-17 production by activated RA PBMC
T1976 867-886 Gene_expression denotes of IL-17 production
T1975 1431-1510 Positive_regulation denotes IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production
T1974 1431-1510 Positive_regulation denotes IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production
T1973 1431-1510 Positive_regulation denotes IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production
T1972 1254-1305 Positive_regulation denotes The production of IL-17 was significantly increased
T1971 584-664 Regulation denotes some cytokines (IL-15 and IL-23) have been reported to regulate IL-17 production
T1970 2124-2157 Negative_regulation denotes inhibition of activator protein-1
T1969 2053-2086 Entity denotes the PI3K/Akt inhibitor wortmannin
T1968 930-934 Entity denotes PBMC
T1967 1737-1739 Protein denotes RA
T1966 1039-1048 Protein denotes anti-CD28
T1965 959-962 Entity denotes n =
T1964 1531-1554 Protein denotes tumor necrosis factor-α
T1962 384-409 Protein denotes proinflammatory cytokines
T1961 1746-1763 Entity denotes Anti-CD3 antibody
T1960 2219-2224 Protein denotes IL-17
T1959 1637-1677 Entity denotes the PBMC of patients with osteoarthritis
T1958 2371-2404 Protein denotes inflammatory cytokine IL-17 in RA
T1957 1050-1074 Protein denotes phytohemagglutinin (PHA)
T1956 1737-1744 Entity denotes RA PBMC
T1955 670-683 Entity denotes intracellular
T1954 2001-2048 Entity denotes the NF-κB inhibitor pyrrolidine dithiocarbamate
T1953 831-835 Protein denotes PI3K
T1952 717-722 Protein denotes IL-17
T1951 1126-1131 Protein denotes IL-17
T1950 1783-1786 Protein denotes Akt
T1949 1309-1345 Entity denotes cells treated with anti-CD3 antibody
T1948 894-935 Entity denotes Peripheral blood mononuclear cells (PBMC)
T1947 568-573 Protein denotes of RA
T1946 1610-1615 Protein denotes IL-17
T1945 268-270 Protein denotes RA
T1944 535-537 Protein denotes RA
T1943 1431-1436 Protein denotes IL-15
T1942 1774-1794 Protein denotes the PI3K/Akt pathway
T1941 2311-2314 Protein denotes Akt
T1940 1929-1949 Entity denotes by activated RA PBMC
T1939 2053-2086 Protein denotes the PI3K/Akt inhibitor wortmannin
T1938 1572-1600 Protein denotes transforming growth factor-β
T1937 2371-2404 Protein denotes inflammatory cytokine IL-17 in RA
T1936 648-653 Protein denotes IL-17
T1935 1405-1414 Protein denotes cytokines
T1934 610-615 Protein denotes IL-23
T1933 273-292 Protein denotes Interleukin (IL)-17
T1932 1269-1277 Protein denotes of IL-17
T1931 1381-1382 Entity denotes P
T1930 1556-1561 Protein denotes IL-1β
T1929 1883-1888 Protein denotes NF-κB
T1927 1438-1472 Protein denotes monocyte chemoattractant protein-1
T1926 1912-1917 Protein denotes IL-17
T1925 890-892 Protein denotes RA
T1924 2091-2099 Entity denotes LY294002
T1923 2005-2020 Entity denotes NF-κB inhibitor
T1922 1362-1371 Protein denotes anti-CD28
T1921 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T1920 1114-1124 Protein denotes chemokines
T1919 1376-1379 Protein denotes PHA
T1918 1563-1568 Protein denotes IL-18
T1917 2306-2314 Protein denotes PI3K/Akt
T1916 1029-1049 Protein denotes anti-CD3, anti-CD28,
T1915 797-829 Protein denotes of the phosphoinositide 3-kinase
T1914 2402-2404 Protein denotes RA
T1913 2066-2075 Entity denotes inhibitor
T1912 1419-1429 Protein denotes chemokines
T1911 600-605 Protein denotes IL-15
T1910 2135-2157 Protein denotes of activator protein-1
T1909 501-509 Protein denotes of IL-17
T1908 1477-1481 Protein denotes IL-6
T1907 870-875 Protein denotes IL-17
T1906 1087-1109 Protein denotes inflammatory cytokines
T1905 1070-1073 Protein denotes PHA
T1904 584-616 Protein denotes some cytokines (IL-15 and IL-23)
T1903 1494-1499 Protein denotes IL-17
T1902 1942-1944 Protein denotes RA
T1901 955-957 Protein denotes RA
T1900 837-892 Protein denotes Akt pathway in the regulation of IL-17 production in RA
T1899 2319-2324 Protein denotes NF-κB
T1898 2306-2314 Protein denotes PI3K/Akt
T16736 21876-21886 Protein denotes that NF-κB
T16735 20981-20983 Protein denotes RA
T16734 21227-21241 Protein denotes c-Rel (lane 5)
T16733 20746-20760 Protein denotes concanavalin A
T16732 20672-20689 Entity denotes the intracellular
T16731 21765-21781 Protein denotes the AP-1 pathway
T16730 21200-21203 Protein denotes p50
T16729 21069-21077 Protein denotes of NF-κB
T16728 20735-20776 Protein denotes anti-CD28, concanavalin A, PHA and IL-15,
T16727 21078-21096 Entity denotes to IL-17 promoters
T16726 20950-20953 Protein denotes Fig
T16725 21655-21660 Protein denotes IκB-α
T16724 21327-21335 Protein denotes anti-CD3
T16723 21246-21257 Entity denotes normal PBMC
T16722 21820-21828 Protein denotes anti-CD3
T16721 21019-21037 Protein denotes anti-CD28 (lane 2)
T16720 20762-20765 Protein denotes PHA
T16719 21574-21579 Protein denotes NF-κB
T16718 21537-21545 Entity denotes LY294002
T15447 20422-20443 Phosphorylation denotes on phosphorylated Akt
T15446 19873-19927 Positive_regulation denotes we evaluated the activation of Akt by western blotting
T15445 20529-20554 Entity denotes LY294002 (data not shown)
T15444 19978-19997 Protein denotes anti-CD3 (10 μg/ml)
T15443 20495-20505 Entity denotes wortmannin
T15442 20300-20307 Protein denotes β-actin
T15441 20422-20443 Protein denotes on phosphorylated Akt
T15440 19737-19808 Protein denotes of PI3K/Akt signal transduction pathway on IL-17 production by anti-CD3
T15439 19822-19872 Entity denotes downstream effector molecules of the PI3K pathway,
T15438 20382-20387 Protein denotes IL-15
T15437 20363-20377 Protein denotes concanavalin A
T15449 20273-20295 Phosphorylation denotes non-phosphorylated Akt
T15448 20358-20467 Regulation denotes PHA, concanavalin A and IL-15 also demonstrated the same effect on phosphorylated Akt as shown with anti-CD3,
T16763 21899-21912 Entity denotes intracellular
T16762 20721-20729 Protein denotes anti-CD3
T16761 21307-21312 Protein denotes NF-κB
T16760 20623-20648 Entity denotes the IL-17 promoter region
T16759 20606-20610 Protein denotes AP-1
T16758 20571-20580 Protein denotes the NF-κB
T16757 20931-20936 Protein denotes IL-17
T16756 21951-21968 Entity denotes by activated PBMC
T16755 20585-20604 Protein denotes activator protein-1
T16754 21192-21195 Protein denotes p65
T16753 21742-21745 Protein denotes Fig
T16752 20981-21037 Entity denotes RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2)
T16751 20914-20936 Entity denotes the promoters of IL-17
T16750 21834-21843 Protein denotes anti-CD28
T16749 21381-21383 Protein denotes RA
T16748 21005-21013 Protein denotes anti-CD3
T16747 21988-21990 Protein denotes RA
T16746 20959-21037 Entity denotes nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2)
T16745 20627-20632 Protein denotes IL-17
T16744 21934-21939 Protein denotes IL-17
T16743 21381-21388 Entity denotes RA PBMC
T16742 21694-21702 Protein denotes of IκB-α
T16741 21446-21451 Protein denotes NF-κB
T16740 21390-21393 Protein denotes Fig
T16739 21341-21350 Protein denotes anti-CD28
T16738 21428-21432 Protein denotes PI3K
T16737 21703-21714 Entity denotes by LY294002
R983 T1910 T1970 themeOf of activator protein-1,inhibition of activator protein-1
R989 T1926 T1977 themeOf IL-17,IL-17 production by activated RA PBMC
R999 T1927 T1975 causeOf monocyte chemoattractant protein-1,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R1000 T1932 T1980 themeOf of IL-17,The production of IL-17
R1007 T1936 T1981 themeOf IL-17,IL-17 production
R1010 T1943 T1973 causeOf IL-15,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R1019 T1952 T1979 themeOf IL-17,IL-17 production
R1020 T1960 T1984 themeOf IL-17,IL-17 production
R1021 T1903 T1983 themeOf IL-17,IL-17 production
R1022 T1904 T1971 causeOf some cytokines (IL-15 and IL-23),some cytokines (IL-15 and IL-23) have been reported to regulate IL-17 production
R1023 T1907 T1976 themeOf IL-17,of IL-17 production
R1024 T1908 T1974 causeOf IL-6,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R1025 T1976 T1978 themeOf of IL-17 production,the regulation of IL-17 production in RA
R1026 T1979 T1982 themeOf IL-17 production,the intracellular signaling pathways that regulate IL-17 production
R1027 T1980 T1972 themeOf The production of IL-17,The production of IL-17 was significantly increased
R1029 T1981 T1971 themeOf IL-17 production,some cytokines (IL-15 and IL-23) have been reported to regulate IL-17 production
R1031 T1983 T1973 themeOf IL-17 production,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R1035 T1983 T1974 themeOf IL-17 production,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R1036 T1983 T1975 themeOf IL-17 production,"IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production"
R2445 T4499 T4594 themeOf "interferon-γ in the joints of RA,","interferon-γ in the joints of RA,"
R2447 T4502 T4593 locationOf macrophage,"macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2449 T4511 T4590 themeOf "IL-15, secreted from activated macrophages","IL-15, secreted from activated macrophages"
R2450 T4513 T4588 themeOf IL-17,of IL-17 production
R2451 T4524 T4595 themeOf of RANKL,"the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),"
R2452 T4598 T4601 themeOf "the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes","It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2453 T4599 T4600 themeOf "the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes","It also stimulates the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2454 T4524 T4596 themeOf of RANKL,"the induction of RANKL (receptor activator of nuclear factor κB [NF-κB] ligand),"
R2455 T4527 T4592 themeOf cytokines released from these cells,cytokines released from these cells
R2456 T4529 T4586 themeOf IL-17,IL-17 production
R2457 T4533 T4593 themeOf "macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α","macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2460 T4534 T4593 locationOf fibroblast,"macrophage and fibroblast cytokines including IL-1, IL-6, IL-15, IL-18 and TNF-α "
R2461 T4538 T4591 themeOf T cell-derived cytokines such as,T cell-derived cytokines such as
R2462 T4548 T4589 themeOf IL-17,of IL-17 production from both
R2467 T4555 T4587 themeOf IL-17,investigate IL-17 production in PBMC of patients with RA and its signaling transduction pathway
R2474 T4561 T4599 themeOf IL-6,"the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R2478 T4565 T4598 themeOf leukemia inhibitory factor,"the production of IL-6 and leukemia inhibitory factor by synoviocytes, and of prostaglandin E2 and nitric oxide by chondrocytes"
R3139 T5856 T5879 themeOf Recombinant TNF-α,Recombinant TNF-α and IL-1 were purchased from Endogen Inc
R3140 T5859 T5879 themeOf IL-1,Recombinant TNF-α and IL-1 were purchased from Endogen Inc
R3525 T6494 T6515 themeOf receptor,T cell receptor activation
R3929 T7206 T7218 themeOf CD4–phycoerythrin,"CD4–phycoerythrin were washed, magnetically labeled with anti-phycoerythrin microbeads"
R4469 T8127 T8152 themeOf mouse monoclonal antibodies,with 500 ng/ml biotinylated mouse monoclonal antibodies against IL-17 (R & D Systems)
R4819 T9110 T9165 themeOf mRNA,mRNA expression
R4820 T9110 T9166 themeOf mRNA,mRNA expression
R4821 T9145 T9164 themeOf mRNA,mRNA was extracted
R5317 T9949 T9958 themeOf Akt,"Western blot analysis of Akt, phosphorylated Akt and IκB-α"
R5318 T9955 T9959 themeOf IκB-α,"Western blot analysis of Akt, phosphorylated Akt and IκB-α"
R5780 T10708 T10745 locationOf Nuclear proteins,Nuclear proteins
R5781 T10721 T10728 partOf of the human IL-17 promoter,IL-17
R5782 T10722 T10744 themeOf Nuclear proteins,Nuclear proteins were extracted from about 5 × 106 PBMC
R5783 T10722 T10745 themeOf Nuclear proteins,Nuclear proteins
R6297 T11578 T11597 causeOf by PHA,the IL-17 production stimulated by PHA
R6298 T11585 T11596 themeOf IL-17,of basal IL-17 secretion
R6299 T11586 T11598 themeOf IL-17,"IL-17 production in PBMC from patients with RA,"
R6300 T11593 T11595 themeOf IL-17,the IL-17 production stimulated by PHA
R6301 T11595 T11597 themeOf the IL-17 production stimulated by PHA,the IL-17 production stimulated by PHA
R6721 T12315 T12337 themeOf IL-17,IL-17 production in PBMC
R6722 T12316 T12336 themeOf IL-17,IL-17 production up to
R6723 T12319 T12333 causeOf anti-CD3,"in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold"
R6724 T12321 T12334 themeOf more IL-17 (approximately 1.3-1.5-fold),the combination of anti-CD28 and anti-CD3 produced more IL-17 (approximately 1.3-1.5-fold)
R6725 T12322 T12338 themeOf IL-17,increased IL-17 production
R6726 T12336 T12333 themeOf IL-17 production up to,"in Table 1, anti-CD3 significantly upregulated IL-17 production up to 3.7-fold"
R6727 T12337 T12335 themeOf IL-17 production in PBMC,Increased IL-17 production in PBMC of patients with RA by anti-CD3
R6728 T12338 T12332 themeOf increased IL-17 production,increased IL-17 production
R7228 T13212 T13250 themeOf IL-17,IL-17 production
R7229 T13223 T13251 themeOf of IL-17,the production of IL-17 from T cells
R7230 T13225 T13246 causeOf inflammatory cytokines,Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
R7231 T13227 T13244 causeOf cytokines released from macrophages and other lymphocytes,cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells
R7232 T13227 T13248 themeOf cytokines released from macrophages and other lymphocytes,cytokines released from macrophages and other lymphocytes
R7233 T13231 T13245 causeOf chemokines,Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
R7234 T13232 T13249 themeOf "inflammatory cytokines released by activated PBMC,","inflammatory cytokines released by activated PBMC,"
R7235 T13237 T13247 themeOf IL-17,of IL-17 production in RA PBMC
R7236 T13242 T13249 causeOf by activated PBMC,"inflammatory cytokines released by activated PBMC,"
R7237 T13247 T13245 themeOf of IL-17 production in RA PBMC,Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
R7238 T13247 T13246 themeOf of IL-17 production in RA PBMC,Regulation of IL-17 production in RA PBMC by inflammatory cytokines and chemokines
R7239 T13251 T13244 themeOf the production of IL-17 from T cells,cytokines released from macrophages and other lymphocytes might have affected the production of IL-17 from T cells
R7922 T14319 T14368 causeOf "inhibitor of PI3K,","inhibitor of PI3K, also markedly inhibited the anti-CD3-induced IL-17 production in RA PBMC"
R7923 T14320 T14365 themeOf IL-17,of IL-17 production
R7924 T14329 T14359 themeOf IL-17,"Having observed the increased IL-17 production in RA PBMC,"
R7925 T14340 T14362 themeOf IL-17,the IL-17 secretion
R7926 T14342 T14369 causeOf by signal transduction inhibitors,Inhibition of IL-17 production by signal transduction inhibitors
R7927 T14349 T14360 themeOf IL-17,the anti-CD3-induced IL-17 production
R7928 T14350 T14357 themeOf IL-17,of IL-17 production
R7929 T14353 T14363 themeOf IL-17,IL-17 production with chemical inhibitors (Fig. 4a)
R7930 T14354 T14358 themeOf IL-17,in anti-CD3-induced IL-17 production
R7931 T14357 T14364 themeOf of IL-17 production,the inhibition of IL-17 production in PBMC
R7932 T14358 T14361 themeOf in anti-CD3-induced IL-17 production,". 3, an significant decrease in anti-CD3-induced IL-17 production was observed"
R7933 T14359 T14367 themeOf "Having observed the increased IL-17 production in RA PBMC,","the increased IL-17 production in RA PBMC,"
R7934 T14360 T14368 themeOf the anti-CD3-induced IL-17 production,"inhibitor of PI3K, also markedly inhibited the anti-CD3-induced IL-17 production in RA PBMC"
R7935 T14362 T14366 themeOf the IL-17 secretion,also downregulated the IL-17 secretion as well as the mitogen-activated protein kinase (MAPK) p38 inhibitor
R7936 T14365 T14369 themeOf of IL-17 production,Inhibition of IL-17 production by signal transduction inhibitors
R8121 T14678 T14692 themeOf IL-17,enhanced IL-17 production
R8122 T14683 T14695 themeOf IL-17 mRNA,IL-17 mRNA expression in RA PBMC
R8123 T14692 T14693 themeOf enhanced IL-17 production,enhanced IL-17 production could be regulated at a transcriptional level
R8124 T14692 T14694 themeOf enhanced IL-17 production,enhanced IL-17 production
R8527 T15429 T15446 themeOf of Akt,we evaluated the activation of Akt by western blotting
R8528 T15434 T15449 themeOf non-phosphorylated Akt,non-phosphorylated Akt
R8529 T15441 T15447 themeOf on phosphorylated Akt,on phosphorylated Akt
R8530 T15441 T15448 themeOf on phosphorylated Akt,"PHA, concanavalin A and IL-15 also demonstrated the same effect on phosphorylated Akt as shown with anti-CD3,"
R9175 T16724 T16779 causeOf anti-CD3,NF-κB activation by anti-CD3 plus anti-CD28
R9176 T16727 T16770 partOf to IL-17 promoters,IL-17
R9177 T16727 T16771 themeOf to IL-17 promoters,nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters
R9178 T16729 T16771 themeOf of NF-κB,nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters
R9179 T16737 T16774 causeOf by LY294002,showed inhibition of degradation of IκB-α by LY294002
R9180 T16739 T16780 causeOf anti-CD28,NF-κB activation by anti-CD3 plus anti-CD28
R9181 T16742 T16777 themeOf of IκB-α,of degradation of IκB-α
R9182 T16744 T16778 themeOf IL-17,IL-17 production by activated PBMC from patients with RA
R9183 T16755 T16776 themeOf activator protein-1,Activation of the NF-κB and activator protein-1 (AP-1)
R9184 T16758 T16775 themeOf the NF-κB,Activation of the NF-κB and activator protein-1 (AP-1)
R9185 T16761 T16779 themeOf NF-κB,NF-κB activation by anti-CD3 plus anti-CD28
R9186 T16761 T16780 themeOf NF-κB,NF-κB activation by anti-CD3 plus anti-CD28
R9187 T16764 T16773 themeOf IL-17,"IL-17 expression,"
R9188 T16767 T16769 partOf the IL-17 promoter (Fig. 7c),IL-17
R9189 T16771 T16772 themeOf nuclear extracts from RA PBMC stimulated with anti-CD3 plus anti-CD28 (lane 2) demonstrated increased binding of NF-κB to IL-17 promoters,increased binding of NF-κB to IL-17 promoters
R9190 T16777 T16774 themeOf of degradation of IκB-α,showed inhibition of degradation of IκB-α by LY294002
R11924 T21621 T21838 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11925 T21621 T21839 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11931 T21651 T21836 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11932 T21636 T21855 themeOf IL-17,IL-17 production
R11933 T21638 T21851 themeOf Akt,Akt activation
R11934 T21640 T21846 themeOf IL-17,IL-17 production
R11935 T21651 T21837 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11936 T21653 T21807 themeOf IL-17,IL-17 production
R11937 T21657 T21848 causeOf anti-CD28,anti-CD28 also increases IL-17 induction in RA PBMC
R11938 T21645 T21815 themeOf the activated p38,the activated p38
R11939 T21647 T21810 themeOf IL-17,IL-17 production
R11940 T21657 T21849 causeOf anti-CD28,anti-CD28 also increases IL-17 induction in RA PBMC
R11941 T21661 T21823 causeOf "by LY294002,","p38 MAPK activation was not affected by LY294002,"
R11942 T21666 T21854 themeOf IL-17,anti-CD3-induced IL-17 production
R11943 T21758 T21811 themeOf of T cell-derived cytokines,of T cell-derived cytokines
R11944 T21674 T21856 themeOf Akt,Akt is phosphorylated
R11945 T21759 T21863 themeOf with NF-κB,association with NF-κB
R11946 T21761 T21821 themeOf IL-17,IL-17 induction in RA PBMC
R11947 T21761 T21822 themeOf IL-17,IL-17 induction in RA PBMC
R11948 T21764 T21832 themeOf CD3,anti-CD3 stimulation
R11949 T21766 T21827 themeOf IL-17,IL-17 is produced mainly by activated CD4+ T cells
R11950 T21677 T21808 themeOf cytokines/chemokines,the induction of cytokines/chemokines by IL-17
R11951 T21770 T21843 causeOf IL-15,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11952 T21677 T21809 themeOf cytokines/chemokines,the induction of cytokines/chemokines by IL-17
R11953 T21679 T21813 themeOf PI3K,of PI3K activation
R11954 T21777 T21812 themeOf of IL-17,this upregulation of IL-17
R11955 T21680 T21808 causeOf by IL-17,the induction of cytokines/chemokines by IL-17
R11956 T21780 T21825 themeOf IL-17,the signal inducing IL-17
R11957 T21780 T21826 themeOf IL-17,the signal inducing IL-17
R11958 T21781 T21841 themeOf IL-17,"IL-17 production in RA,"
R11959 T21681 T21861 themeOf IL-17,IL-17 production
R11960 T21783 T21828 themeOf NF-κB,resultant NF-κB activation
R11961 T21683 T21819 themeOf of IL-17,in the induction of IL-17
R11962 T21683 T21820 themeOf of IL-17,in the induction of IL-17
R11963 T21789 T21844 causeOf by p38 [32],"In myocytes, IκB kinase-β is activated by p38 [32]"
R11964 T21687 T21834 locationOf T cell,T cell receptor (TCR)
R11965 T21792 T21816 themeOf IL-17,"IL-17 production in RA,"
R11966 T21793 T21835 themeOf IL-17,anti-CD3-induced IL-17 production
R11967 T21796 T21858 themeOf of IL-17,the induction of IL-17 in RA
R11968 T21796 T21859 themeOf of IL-17,the induction of IL-17 in RA
R11969 T21689 T21844 themeOf IκB kinase-β,"In myocytes, IκB kinase-β is activated by p38 [32]"
R11970 T21798 T21852 themeOf a T cell-derived cytokine with proinflammatory properties,a T cell-derived cytokine with proinflammatory properties
R11971 T21690 T21818 causeOf some cytokines (IL-15 and IL-23),"some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]"
R11972 T21696 T21829 themeOf the T cell receptor,the T cell receptor
R11973 T21804 T21842 causeOf MCP-1 as well as TCR ligation,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11974 T21807 T21830 themeOf IL-17 production,IL-17 production can be regulated by certain signaling pathways
R11975 T21701 T21857 themeOf IL-17,IL-17 production from RA PBMC
R11976 T21817 T21842 themeOf the production of IL-17 in RA PBMC,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11977 T21817 T21843 themeOf the production of IL-17 in RA PBMC,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11978 T21821 T21848 themeOf IL-17 induction in RA PBMC,anti-CD28 also increases IL-17 induction in RA PBMC
R11979 T21822 T21849 themeOf IL-17 induction in RA PBMC,anti-CD28 also increases IL-17 induction in RA PBMC
R11980 T21703 T21788 partOf the IL-17 promoter,IL-17
R11981 T21704 T21831 themeOf "cytokines,","the T cell-derived cytokines,"
R11982 T21711 T21853 themeOf IL-17,IL-17 production
R11983 T21835 T21814 themeOf anti-CD3-induced IL-17 production,We also found that anti-CD3-induced IL-17 production was downregulated by the addition
R11984 T21835 T21840 themeOf anti-CD3-induced IL-17 production,that anti-CD3-induced IL-17 production was downregulated by the addition
R11985 T21713 T21862 themeOf IL-17,IL-17 production
R11986 T21719 T21850 themeOf of IL-17,"the upregulation of IL-17 in RA,"
R11987 T21847 T21818 themeOf "IL-17 production [13,14]","some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]"
R11988 T21723 T21834 themeOf T cell receptor (TCR),T cell receptor (TCR)
R11989 T21725 T21817 themeOf of IL-17,the production of IL-17 in RA PBMC
R11990 T21730 T21860 themeOf NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33],the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]
R11991 T21857 T21845 themeOf IL-17 production from RA PBMC,increased IL-17 production from RA PBMC in a dose-dependent manner
R11992 T21741 T21847 themeOf IL-17,"IL-17 production [13,14]"
R11993 T21744 T21833 themeOf IL-17,IL-17 production
R11994 T21745 T21829 locationOf T cell,the T cell receptor
R11995 T21746 T21824 themeOf of IL-17,production of IL-17 in RA PBMC
R12356 T22584 T22603 themeOf of anti-IL-17,"the successful introduction of anti-IL-17 in RA,"
R12357 T22586 T22601 causeOf by activated T cells,upregulation of IL-17 by activated T cells in patients with RA
R12358 T22587 T22605 themeOf IL-17,of IL-17 production in RA
R12359 T22592 T22602 themeOf of IL-17,We have detected a more pronounced production of IL-17 from RA PBMC in response to IL-15 and MCP-1 as well as stimulation
R12360 T22596 T22601 themeOf of IL-17,upregulation of IL-17 by activated T cells in patients with RA
R12361 T22605 T22604 themeOf of IL-17 production in RA,the regulation of IL-17 production in RA

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1443 0-9 VBN denotes Increased
T1444 10-24 JJ denotes interleukin-17
T1445 25-35 NN denotes production
T1446 36-39 IN denotes via
T1447 40-41 DT denotes a
T1448 42-58 NN denotes phosphoinositide
T1449 59-71 NN denotes 3-kinase/Akt
T1450 72-75 CC denotes and
T1451 76-83 JJ denotes nuclear
T1452 84-90 NN denotes factor
T1453 91-92 . denotes κ
T1454 92-103 JJ denotes B-dependent
T1455 104-111 NN denotes pathway
T1456 112-114 IN denotes in
T1457 115-123 NNS denotes patients
T1458 124-128 IN denotes with
T1459 129-139 JJ denotes rheumatoid
T1460 140-149 NNS denotes arthritis
T5824 7256-7266 NNP denotes Calbiochem
T9906 13666-13683 NN denotes chemiluminescence
T11539 16020-16024 IN denotes from
T22563 28795-28796 . denotes .
T22562 28793-28795 NNP denotes RA
T22561 28790-28792 IN denotes in
T22560 28777-28789 NNS denotes applications
T22559 28765-28776 JJ denotes therapeutic
T22558 28761-28764 JJ denotes new
T22557 28758-28760 IN denotes of
T22556 28748-28757 VBG denotes targeting
T22555 28738-28747 JJ denotes molecular
T22554 28731-28737 JJ denotes future
T22553 28727-28730 DT denotes the
T22552 28723-28726 IN denotes for
T22551 28711-28722 NN denotes information
T22550 28705-28710 VBN denotes added
T22549 28700-28704 VBP denotes have
T22548 28692-28699 NNS denotes results
T22547 28688-28691 PRP$ denotes our
T22546 28686-28687 , denotes ,
T22545 28684-28686 NNP denotes RA
T22544 28681-28683 IN denotes in
T22543 28670-28680 NN denotes anti-IL-17
T22542 28667-28669 IN denotes of
T22541 28654-28666 NN denotes introduction
T22540 28643-28653 JJ denotes successful
T22539 28639-28642 DT denotes the
T22538 28636-28638 IN denotes on
T22537 28631-28635 NNS denotes data
T22536 28624-28630 JJ denotes recent
T22535 28619-28623 IN denotes with
T22534 28610-28618 RB denotes Together
T22533 28608-28609 . denotes .
T22532 28596-28608 NN denotes pathogenesis
T22531 28593-28595 NNP denotes RA
T22530 28590-28592 IN denotes in
T22529 28580-28589 VBN denotes neglected
T22528 28575-28579 VBN denotes been
T22527 28566-28574 RB denotes hitherto
T22526 28562-28565 VBZ denotes has
T22525 28556-28561 WDT denotes which
T22524 28554-28555 , denotes ,
T22523 28549-28554 NNS denotes cells
T22522 28547-28548 NNP denotes T
T22521 28544-28546 IN denotes of
T22520 28539-28543 NN denotes role
T22519 28535-28538 DT denotes the
T22518 28525-28534 VB denotes highlight
T22517 28521-28524 CC denotes and
T22516 28519-28520 , denotes ,
T22515 28517-28519 NNP denotes RA
T22514 28514-28516 IN denotes in
T22513 28503-28513 NN denotes production
T22512 28497-28502 JJ denotes IL-17
T22511 28494-28496 IN denotes of
T22510 28483-28493 NN denotes regulation
T22509 28479-28482 DT denotes the
T22508 28476-28478 IN denotes of
T22507 28465-28475 NNS denotes mechanisms
T22506 28456-28464 JJ denotes cellular
T22505 28451-28455 IN denotes into
T22504 28442-28450 NNS denotes insights
T22503 28434-28441 VBP denotes provide
T22502 28429-28433 NNS denotes data
T22501 28425-28428 PRP$ denotes Our
T22500 28423-28424 . denotes .
T22499 28413-28423 NN denotes activation
T22498 28407-28412 NN denotes NF-κB
T22497 28397-28406 JJ denotes resultant
T22496 28392-28396 IN denotes with
T22495 28384-28391 NN denotes pathway
T22494 28375-28383 JJ denotes PI3K/Akt
T22493 28371-28374 DT denotes the
T22492 28367-28370 IN denotes via
T22491 28356-28366 NN denotes activation
T22490 28353-28355 IN denotes of
T22489 28346-28352 NN denotes result
T22488 28342-28345 DT denotes the
T22487 28339-28341 VB denotes be
T22486 28333-28338 MD denotes could
T22485 28330-28332 NNP denotes RA
T22484 28325-28329 IN denotes with
T22483 28316-28324 NNS denotes patients
T22482 28313-28315 IN denotes in
T22481 28307-28312 NNS denotes cells
T22480 28305-28306 NNP denotes T
T22479 28295-28304 VBN denotes activated
T22478 28292-28294 IN denotes by
T22477 28286-28291 NNP denotes IL-17
T22476 28283-28285 IN denotes of
T22475 28270-28282 NN denotes upregulation
T22474 28265-28269 IN denotes that
T22473 28259-28264 VBN denotes shown
T22472 28254-28258 RB denotes also
T22471 28249-28253 VBP denotes have
T22470 28246-28248 PRP denotes We
T22469 28244-28245 . denotes .
T22468 28235-28244 NN denotes anti-CD28
T22467 28234-28235 NN denotes /
T22466 28226-28234 JJ denotes anti-CD3
T22465 28223-28225 IN denotes by
T22464 28211-28222 NN denotes stimulation
T22463 28208-28210 IN denotes as
T22462 28203-28207 RB denotes well
T22461 28200-28202 RB denotes as
T22460 28194-28199 NNP denotes MCP-1
T22459 28190-28193 CC denotes and
T22458 28184-28189 NNP denotes IL-15
T22457 28181-28183 TO denotes to
T22456 28172-28180 NN denotes response
T22455 28169-28171 IN denotes in
T22454 28164-28168 NNP denotes PBMC
T22453 28161-28163 NNP denotes RA
T22452 28156-28160 IN denotes from
T22451 28150-28155 NNP denotes IL-17
T22450 28147-28149 IN denotes of
T22449 28136-28146 NN denotes production
T22448 28125-28135 JJ denotes pronounced
T22447 28120-28124 RBR denotes more
T22446 28118-28119 DT denotes a
T22445 28109-28117 VBN denotes detected
T22444 28104-28108 VBP denotes have
T22443 28101-28103 PRP denotes We
T21445 28086-28087 . denotes .
T21444 28084-28086 NNP denotes RA
T21443 28081-28083 IN denotes in
T21442 28071-28080 NNS denotes therapies
T21441 28062-28070 JJ denotes targeted
T21440 28058-28061 JJ denotes new
T21439 28047-28057 VBG denotes developing
T21438 28044-28046 IN denotes of
T21437 28036-28043 NN denotes element
T21436 28026-28035 JJ denotes important
T21435 28023-28025 DT denotes an
T21434 28020-28022 VBZ denotes is
T21433 28012-28019 NN denotes pathway
T21432 28002-28011 VBG denotes signaling
T21431 27996-28001 NNP denotes IL-17
T21430 27992-27995 DT denotes the
T21429 27978-27991 VBG denotes understanding
T21428 27976-27977 , denotes ,
T21427 27975-27976 NNP denotes ]
T21426 27966-27975 CD denotes 2,6,34-36
T21425 27965-27966 NNP denotes [
T21424 27958-27964 NNS denotes models
T21423 27951-27957 NN denotes animal
T21422 27948-27950 IN denotes in
T21421 27938-27947 NNS denotes arthritis
T21420 27925-27937 VBG denotes ameliorating
T21419 27921-27924 IN denotes for
T21418 27910-27920 JJ denotes anti-IL-17
T21417 27907-27909 IN denotes of
T21416 27897-27906 NN denotes induction
T21415 27886-27896 JJ denotes successful
T21414 27882-27885 CC denotes and
T21413 27871-27881 NNS denotes activities
T21412 27855-27870 JJ denotes proinflammatory
T21411 27851-27854 PRP$ denotes its
T21410 27839-27850 VBG denotes Considering
T21409 27837-27838 . denotes .
T21408 27829-27837 NNP denotes LY294002
T21407 27825-27828 CC denotes and
T21406 27820-27824 NNP denotes PDTC
T21405 27817-27819 IN denotes by
T21404 27808-27816 NN denotes promoter
T21403 27802-27807 NNP denotes IL-17
T21402 27798-27801 DT denotes the
T21401 27795-27797 IN denotes in
T21400 27786-27794 NN denotes activity
T21399 27778-27785 JJ denotes binding
T21398 27772-27777 JJ denotes NF-κB
T21397 27769-27771 IN denotes of
T21396 27760-27768 VBG denotes blocking
T21395 27747-27759 JJ denotes simultaneous
T21394 27739-27746 VBG denotes showing
T21393 27727-27738 NNS denotes experiments
T21392 27723-27726 PRP$ denotes our
T21391 27720-27722 IN denotes of
T21390 27714-27719 NN denotes basis
T21389 27710-27713 DT denotes the
T21388 27707-27709 IN denotes on
T21387 27705-27706 , denotes ,
T21386 27703-27705 NNP denotes RA
T21385 27700-27702 IN denotes in
T21384 27694-27699 NNP denotes IL-17
T21383 27691-27693 IN denotes of
T21382 27678-27690 NN denotes upregulation
T21381 27674-27677 DT denotes the
T21380 27671-27673 IN denotes of
T21379 27660-27670 NN denotes arbitrator
T21378 27650-27659 JJ denotes important
T21377 27647-27649 DT denotes an
T21376 27644-27646 VB denotes be
T21375 27638-27643 MD denotes could
T21374 27627-27637 NN denotes activation
T21373 27621-27626 NN denotes NF-κB
T21372 27611-27620 JJ denotes resultant
T21371 27607-27610 CC denotes and
T21370 27598-27606 NNP denotes PI3K/Akt
T21369 27593-27597 IN denotes that
T21368 27580-27592 VBD denotes demonstrated
T21367 27572-27579 RB denotes clearly
T21366 27567-27571 NNS denotes data
T21365 27563-27566 PRP$ denotes Our
T21364 27561-27562 . denotes .
T21363 27554-27561 VBG denotes lacking
T21362 27550-27553 VBP denotes are
T21361 27544-27549 NNP denotes IL-17
T21360 27535-27543 VBG denotes inducing
T21359 27528-27534 NN denotes signal
T21358 27524-27527 DT denotes the
T21357 27521-27523 IN denotes on
T21356 27516-27520 NNS denotes data
T21355 27512-27515 DT denotes the
T21354 27510-27511 , denotes ,
T21353 27505-27510 NNS denotes types
T21352 27500-27504 NN denotes cell
T21351 27495-27499 JJ denotes many
T21350 27492-27494 IN denotes in
T21349 27484-27491 NNS denotes signals
T21348 27473-27483 VBG denotes activating
T21347 27465-27472 VB denotes deliver
T21346 27462-27464 TO denotes to
T21345 27453-27461 VBN denotes reported
T21344 27448-27452 VBN denotes been
T21343 27443-27447 VBP denotes have
T21342 27437-27442 NNP denotes NF-κB
T21341 27432-27436 IN denotes with
T21340 27420-27431 NN denotes association
T21339 27417-27419 IN denotes in
T21338 27413-27416 NNP denotes Akt
T21337 27406-27412 NN denotes kinase
T21336 27395-27405 JJ denotes downstream
T21335 27391-27394 PRP$ denotes its
T21334 27387-27390 CC denotes and
T21333 27382-27386 NNP denotes PI3K
T21332 27373-27381 IN denotes Although
T21331 27371-27372 . denotes .
T21330 27370-27371 -RRB- denotes )
T21329 27365-27370 VBN denotes shown
T21328 27361-27364 RB denotes not
T21327 27356-27360 NNS denotes data
T21326 27355-27356 -LRB- denotes (
T21325 27343-27354 NNS denotes experiments
T21324 27339-27342 PRP$ denotes our
T21323 27336-27338 IN denotes in
T21322 27326-27335 VBN denotes activated
T21321 27322-27325 RB denotes not
T21320 27318-27321 VBD denotes was
T21319 27316-27317 , denotes ,
T21318 27296-27316 NNS denotes cytokines/chemokines
T21317 27292-27295 IN denotes for
T21316 27284-27291 NN denotes pathway
T21315 27274-27283 VBG denotes signaling
T21314 27264-27273 JJ denotes important
T21313 27256-27263 DT denotes another
T21312 27254-27255 , denotes ,
T21311 27247-27254 NN denotes pathway
T21310 27234-27246 NN denotes transduction
T21309 27227-27233 NN denotes signal
T21308 27222-27226 NNP denotes AP-1
T21307 27218-27221 DT denotes the
T21306 27216-27217 , denotes ,
T21305 27208-27216 NN denotes contrast
T21304 27205-27207 IN denotes In
T21303 27203-27204 . denotes .
T21302 27199-27203 NNP denotes PBMC
T21301 27196-27198 NNP denotes RA
T21300 27193-27195 IN denotes in
T21299 27187-27192 NNP denotes IL-17
T21298 27184-27186 IN denotes of
T21297 27174-27183 NN denotes induction
T21296 27170-27173 DT denotes the
T21295 27167-27169 IN denotes in
T21294 27158-27166 VBN denotes involved
T21293 27149-27157 RB denotes actively
T21292 27144-27148 RB denotes also
T21291 27141-27143 VBZ denotes is
T21290 27133-27140 NN denotes pathway
T21289 27127-27132 NNP denotes NF-κB
T21288 27123-27126 DT denotes the
T21287 27118-27122 IN denotes that
T21286 27111-27117 JJ denotes likely
T21285 27106-27110 RBS denotes most
T21284 27103-27105 VBZ denotes is
T21283 27100-27102 PRP denotes it
T21282 27098-27099 , denotes ,
T21281 27087-27098 NNS denotes experiments
T21280 27083-27086 PRP$ denotes our
T21279 27080-27082 IN denotes in
T21278 27071-27079 NNS denotes mitogens
T21277 27068-27070 CC denotes or
T21276 27062-27067 NN denotes IL-15
T21275 27060-27061 , denotes ,
T21274 27051-27060 NN denotes anti-CD28
T21273 27050-27051 NN denotes /
T21272 27042-27050 JJ denotes anti-CD3
T21271 27039-27041 IN denotes by
T21270 27029-27038 VBN denotes activated
T21269 27024-27028 RB denotes also
T21268 27020-27023 VBD denotes was
T21267 27014-27019 NNP denotes NF-κB
T21266 27009-27013 IN denotes that
T21265 27004-27008 NN denotes fact
T21264 27000-27003 DT denotes the
T21263 26997-26999 IN denotes of
T21262 26992-26996 NN denotes view
T21261 26989-26991 IN denotes In
T21260 26987-26988 . denotes .
T21259 26985-26987 NNP denotes RA
T21258 26982-26984 IN denotes in
T21257 26976-26981 NNP denotes IL-17
T21256 26973-26975 IN denotes of
T21255 26963-26972 NN denotes induction
T21254 26959-26962 DT denotes the
T21253 26956-26958 IN denotes in
T21252 26951-26955 NNP denotes PI3K
T21251 26948-26950 IN denotes of
T21250 26936-26947 NN denotes involvement
T21249 26927-26935 JJ denotes possible
T21248 26923-26926 DT denotes the
T21247 26914-26922 VBZ denotes suggests
T21246 26902-26913 NN denotes stimulation
T21245 26893-26901 JJ denotes anti-CD3
T21244 26888-26892 IN denotes upon
T21243 26873-26887 VBN denotes phosphorylated
T21242 26870-26872 VBZ denotes is
T21139 26281-26284 MD denotes can
T21138 26277-26280 NN denotes p38
T21137 26267-26276 VBN denotes activated
T21136 26263-26266 DT denotes the
T21135 26259-26262 CC denotes and
T21134 26257-26258 , denotes ,
T21133 26256-26257 NNP denotes ]
T21132 26254-26256 CD denotes 32
T21131 26253-26254 NNP denotes [
T21130 26249-26252 CD denotes p38
T21129 26246-26248 IN denotes by
T21128 26236-26245 VBN denotes activated
T21127 26233-26235 VBZ denotes is
T21126 26224-26232 NN denotes kinase-β
T21125 26220-26223 NNP denotes IκB
T21124 26218-26219 , denotes ,
T21123 26210-26218 NNS denotes myocytes
T21122 26207-26209 IN denotes In
T21121 26205-26206 . denotes .
T21120 26202-26205 CD denotes p38
T21119 26198-26201 CC denotes and
T21118 26192-26197 NNP denotes NF-κB
T21117 26184-26191 IN denotes between
T21116 26174-26183 NN denotes crosstalk
T21115 26165-26173 VBZ denotes supports
T21114 26156-26164 NN denotes evidence
T21113 26153-26155 IN denotes of
T21112 26146-26152 NN denotes series
T21111 26144-26145 DT denotes a
T21110 26139-26143 IN denotes that
T21109 26127-26138 JJ denotes interesting
T21108 26124-26126 VBZ denotes is
T21107 26121-26123 PRP denotes It
T21106 26119-26120 . denotes .
T21105 26110-26119 NN denotes inhibitor
T21104 26105-26109 NNP denotes MAPK
T21103 26101-26104 JJ denotes p38
T21102 26099-26100 DT denotes a
T21101 26097-26098 , denotes ,
T21100 26089-26097 NNP denotes SB203580
T21099 26086-26088 IN denotes of
T21098 26077-26085 NN denotes addition
T21097 26073-26076 DT denotes the
T21096 26070-26072 IN denotes by
T21095 26056-26069 VBN denotes downregulated
T21094 26052-26055 VBD denotes was
T21093 26041-26051 NN denotes production
T21092 26035-26040 NN denotes IL-17
T21091 26018-26034 JJ denotes anti-CD3-induced
T21090 26013-26017 IN denotes that
T21089 26007-26012 VBD denotes found
T21088 26002-26006 RB denotes also
T21087 25999-26001 PRP denotes We
T21086 25997-25998 . denotes .
T21085 25986-25997 NN denotes stimulation
T21084 25978-25985 IN denotes without
T21083 25967-25977 NN denotes production
T21082 25961-25966 JJ denotes basal
T21081 25958-25960 IN denotes of
T21080 25951-25957 NNS denotes levels
T21079 25940-25950 JJ denotes comparable
T21078 25937-25939 TO denotes to
T21077 25932-25936 NNP denotes PDTC
T21076 25922-25931 NN denotes inhibitor
T21075 25916-25921 NNP denotes NF-κB
T21074 25912-25915 DT denotes the
T21073 25908-25911 CC denotes and
T21072 25899-25907 NNP denotes LY294002
T21071 25889-25898 NN denotes inhibitor
T21070 25884-25888 NNP denotes PI3K
T21069 25880-25883 DT denotes the
T21068 25877-25879 IN denotes by
T21067 25868-25876 VBN denotes hampered
T21066 25854-25867 RB denotes significantly
T21065 25850-25853 VBD denotes was
T21064 25845-25849 NNP denotes PBMC
T21063 25842-25844 NNP denotes RA
T21062 25839-25841 IN denotes in
T21061 25828-25838 NN denotes production
T21060 25822-25827 NN denotes IL-17
T21059 25805-25821 JJ denotes anti-CD3-induced
T21058 25800-25804 IN denotes that
T21057 25789-25799 VBD denotes identified
T21056 25786-25788 PRP denotes We
T21055 25784-25785 . denotes .
T21054 25780-25784 NNP denotes PBMC
T21053 25777-25779 NNP denotes RA
T21052 25774-25776 IN denotes in
T21051 25768-25773 NNP denotes IL-17
T21050 25765-25767 IN denotes of
T21049 25755-25764 NN denotes induction
T21048 25751-25754 DT denotes the
T21047 25748-25750 IN denotes in
T21046 25739-25747 VBN denotes involved
T21045 25732-25738 RB denotes mainly
T21044 25728-25731 VBD denotes was
T21043 25720-25727 NN denotes pathway
T21042 25710-25719 VBG denotes signaling
T21041 25704-25709 WDT denotes which
T21040 25695-25703 VBD denotes examined
T21039 25685-25694 RB denotes therefore
T21038 25682-25684 PRP denotes we
T21037 25680-25681 , denotes ,
T21036 25670-25680 NNS denotes inhibitors
T21035 25657-25669 NN denotes transduction
T21034 25650-25656 NN denotes signal
T21033 25644-25649 VBG denotes using
T21032 25641-25643 IN denotes By
T21031 25639-25640 . denotes .
T21030 25631-25639 NNS denotes pathways
T21029 25621-25630 VBG denotes signaling
T21028 25613-25620 JJ denotes certain
T21027 25610-25612 IN denotes by
T21026 25600-25609 VBN denotes regulated
T21025 25597-25599 VB denotes be
T21024 25593-25596 MD denotes can
T21023 25582-25592 NN denotes production
T21022 25576-25581 JJ denotes IL-17
T21021 25572-25575 WRB denotes how
T21020 25569-25571 IN denotes on
T21019 25559-25568 JJ denotes available
T21018 25554-25558 VBN denotes been
T21017 25549-25553 VBP denotes have
T21016 25544-25548 NNS denotes data
T21015 25541-25543 DT denotes no
T21014 25539-25540 , denotes ,
T21013 25538-25539 NNP denotes ]
T21012 25531-25538 CD denotes 8,30,31
T21011 25530-25531 NNP denotes [
T21010 25523-25529 RB denotes widely
T21009 25512-25522 VBN denotes documented
T21008 25507-25511 VBN denotes been
T21007 25503-25506 VBZ denotes has
T21006 25497-25502 NNP denotes IL-17
T21005 25494-25496 IN denotes by
T21004 25473-25493 NNS denotes cytokines/chemokines
T21003 25470-25472 IN denotes of
T21002 25460-25469 NN denotes induction
T21001 25456-25459 DT denotes the
T21000 25452-25455 IN denotes for
T20999 25444-25451 NN denotes pathway
T20998 25434-25443 VBG denotes signaling
T20997 25430-25433 DT denotes the
T20996 25421-25429 IN denotes Although
T20995 25419-25420 . denotes .
T20994 25415-25419 NNP denotes PBMC
T20993 25412-25414 NNP denotes RA
T20992 25409-25411 IN denotes in
T20991 25399-25408 NN denotes induction
T20990 25393-25398 NNP denotes IL-17
T20989 25383-25392 VBZ denotes increases
T20988 25378-25382 RB denotes also
T20987 25368-25377 NN denotes anti-CD28
T20986 25367-25368 NN denotes /
T20985 25359-25367 JJ denotes anti-CD3
T20984 25351-25358 IN denotes through
T20983 25340-25350 NN denotes activation
T20982 25335-25339 NN denotes cell
T20981 25333-25334 NNP denotes T
T20980 25331-25332 , denotes ,
T20979 25330-25331 NNP denotes ]
T20978 25328-25330 CD denotes 25
T20977 25327-25328 NNP denotes [
T20976 25315-25326 NNS denotes individuals
T20975 25308-25314 JJ denotes normal
T20974 25304-25307 IN denotes for
T20973 25295-25303 VBN denotes reported
T20972 25292-25294 IN denotes As
T20971 25290-25291 . denotes .
T20970 25282-25290 NNS denotes cultures
T20969 25277-25281 NNP denotes PBMC
T20968 25274-25276 IN denotes in
T20967 25252-25273 NNS denotes monocytes/macrophages
T20966 25249-25251 IN denotes of
T20965 25238-25248 NN denotes activation
T20964 25234-25237 DT denotes the
T20963 25226-25233 IN denotes through
T20962 25220-25225 NNS denotes cells
T20961 25218-25219 NNP denotes T
T20960 25215-25217 IN denotes on
T20959 25204-25214 RB denotes indirectly
T20958 25196-25203 NNS denotes effects
T20957 25190-25195 VB denotes exert
T20956 25184-25189 MD denotes might
T20955 25181-25183 PRP denotes it
T20954 25179-25180 , denotes ,
T20953 25169-25179 NN denotes activation
T20952 25164-25168 NN denotes cell
T20951 25162-25163 NNP denotes T
T20950 25154-25161 VBZ denotes induces
T20949 25145-25153 RB denotes directly
T20948 25139-25144 NNP denotes MCP-1
T20947 25134-25138 WDT denotes that
T20946 25129-25133 NNS denotes data
T20945 25126-25128 DT denotes no
T20944 25121-25125 VBD denotes were
T20943 25115-25120 EX denotes there
T20942 25106-25114 IN denotes Although
T20941 25104-25105 . denotes .
T20940 25103-25104 NN denotes ]
T20939 25101-25103 CD denotes 13
T20938 25100-25101 JJ denotes [
T20937 25097-25099 RB denotes so
T20936 25094-25096 VB denotes do
T20935 25090-25093 RB denotes not
T20934 25086-25089 VBD denotes did
T20933 25080-25085 NNP denotes TNF-α
T20932 25076-25079 CC denotes but
T20931 25074-25075 , denotes ,
T20930 25070-25074 NNP denotes PBMC
T20929 25067-25069 IN denotes in
T20917 24988-24998 JJ denotes consistent
T20916 24983-24987 VBD denotes were
T20915 24978-24982 NNS denotes data
T20914 24974-24977 PRP$ denotes Our
T20913 24972-24973 . denotes .
T20912 24962-24972 NN denotes production
T20911 24956-24961 JJ denotes IL-17
T20910 24949-24955 VB denotes affect
T20909 24945-24948 RB denotes not
T20908 24941-24944 VBD denotes did
T20907 24939-24940 , denotes ,
T20906 24933-24939 NNS denotes joints
T20905 24930-24932 NNP denotes RA
T20904 24927-24929 IN denotes in
T20903 24917-24926 VBN denotes increased
T20902 24914-24916 VB denotes be
T20901 24911-24913 TO denotes to
T20900 24907-24910 CC denotes and
T20899 24896-24906 NNS denotes properties
T20898 24880-24895 JJ denotes proinflammatory
T20897 24875-24879 VB denotes have
T20896 24872-24874 TO denotes to
T20895 24866-24871 VBN denotes known
T20894 24862-24865 VBP denotes are
T20893 24856-24861 WDT denotes which
T20892 24854-24855 , denotes ,
T20891 24849-24854 NNP denotes TNF-α
T20890 24845-24848 CC denotes and
T20889 24840-24844 NNP denotes IL-1
T20888 24838-24839 , denotes ,
T20887 24830-24838 NN denotes contrast
T20886 24827-24829 IN denotes In
T20885 24825-24826 . denotes .
T20884 24817-24825 RB denotes markedly
T20883 24812-24816 RBR denotes more
T20882 24801-24811 NN denotes production
T20881 24795-24800 JJ denotes IL-17
T20880 24785-24794 VBD denotes augmented
T20879 24776-24784 NN denotes ligation
T20878 24772-24775 NNP denotes TCR
T20877 24769-24771 TO denotes to
T20876 24763-24768 NN denotes MCP-1
T20875 24760-24762 CC denotes or
T20874 24754-24759 NN denotes IL-15
T20873 24747-24753 VBG denotes Adding
T20872 24745-24746 . denotes .
T20871 24741-24745 NNP denotes PBMC
T20870 24738-24740 NNP denotes RA
T20869 24735-24737 IN denotes in
T21236 26845-26850 NNS denotes hours
T21235 26843-26844 CD denotes 2
T21234 26840-26842 IN denotes at
T21233 26831-26839 NN denotes activity
T21232 26828-26830 IN denotes of
T21231 26823-26827 NN denotes loss
T21230 26815-26822 JJ denotes gradual
T21229 26813-26814 DT denotes a
T21228 26809-26812 CC denotes and
T21227 26804-26808 NN denotes hour
T21226 26802-26803 CD denotes 1
T21225 26799-26801 IN denotes at
T21224 26788-26798 NN denotes activation
T21223 26784-26787 NNP denotes Akt
T21222 26781-26783 IN denotes of
T21221 26772-26780 NN denotes response
T21220 26764-26771 JJ denotes maximal
T21219 26762-26763 DT denotes a
T21218 26757-26761 VB denotes have
T21217 26754-26756 TO denotes to
T21216 26747-26753 VBD denotes seemed
T21215 26742-26746 NNP denotes PI3K
T21214 26739-26741 IN denotes of
T21213 26731-26738 NN denotes pathway
T21212 26720-26730 JJ denotes downstream
T21211 26718-26719 DT denotes a
T21210 26714-26717 IN denotes for
T21209 26707-26713 NN denotes search
T21208 26703-26706 DT denotes The
T21207 26701-26702 . denotes .
T21206 26690-26701 NNS denotes experiments
T21205 26683-26689 JJ denotes future
T21204 26680-26682 IN denotes in
T21203 26672-26679 VBN denotes studied
T21202 26669-26671 VB denotes be
T21201 26666-26668 TO denotes to
T21200 26660-26665 VBZ denotes needs
T21199 26649-26659 NN denotes production
T21198 26643-26648 NNP denotes IL-17
T21197 26639-26642 IN denotes for
T21196 26633-26638 NNP denotes NF-κB
T21195 26629-26632 CC denotes and
T21194 26625-26628 CD denotes p38
T21193 26617-26624 IN denotes between
T21192 26604-26616 NN denotes relationship
T21191 26597-26603 JJ denotes direct
T21190 26593-26596 DT denotes The
T21189 26591-26592 . denotes .
T21188 26581-26591 NN denotes activation
T21187 26576-26580 CD denotes PI3K
T21186 26573-26575 IN denotes of
T21185 26561-26572 JJ denotes independent
T21184 26553-26560 NN denotes pathway
T21183 26548-26552 NNP denotes MAPK
T21182 26544-26547 JJ denotes p38
T21181 26542-26543 DT denotes a
T21180 26538-26541 IN denotes for
T21179 26529-26537 NN denotes evidence
T21178 26525-26528 DT denotes the
T21177 26516-26524 VBD denotes provided
T21176 26510-26515 WDT denotes which
T21175 26508-26509 , denotes ,
T21174 26500-26508 NNP denotes LY294002
T21173 26497-26499 IN denotes by
T21172 26487-26496 VBN denotes decreased
T21171 26483-26486 VBD denotes was
T21170 26474-26482 NN denotes activity
T21169 26466-26473 JJ denotes binding
T21168 26460-26465 NNP denotes NF-κB
T21167 26452-26459 IN denotes whereas
T21166 26450-26451 , denotes ,
T21165 26442-26450 NNP denotes LY294002
T21164 26439-26441 IN denotes by
T21163 26430-26438 VBN denotes affected
T21162 26426-26429 RB denotes not
T21161 26422-26425 VBD denotes was
T21160 26411-26421 NN denotes activation
T21159 26406-26410 NNP denotes MAPK
T21158 26402-26405 CD denotes p38
T21157 26397-26401 IN denotes that
T21156 26388-26396 VBD denotes revealed
T21155 26380-26387 NNS denotes results
T21154 26376-26379 PRP$ denotes Our
T21153 26374-26375 . denotes .
T21152 26373-26374 NNP denotes ]
T20868 24729-24734 NNP denotes IL-17
T20867 24726-24728 IN denotes of
T20866 24715-24725 NN denotes production
T20865 24711-24714 DT denotes the
T20864 24701-24710 VBD denotes increased
T20863 24687-24700 RB denotes significantly
T20862 24678-24686 NN denotes ligation
T20861 24674-24677 NNP denotes TCR
T20860 24671-24673 IN denotes as
T20859 24666-24670 RB denotes well
T20858 24663-24665 RB denotes as
T20857 24657-24662 NNP denotes MCP-1
T20856 24653-24656 CC denotes and
T20855 24647-24652 NNP denotes IL-15
T20854 24642-24646 IN denotes that
T20853 24629-24641 VBD denotes demonstrated
T20852 24621-24628 NNS denotes studies
T20851 24617-24620 PRP$ denotes Our
T20850 24615-24616 . denotes .
T20849 24606-24615 NN denotes anti-CD28
T20848 24605-24606 NN denotes /
T20847 24597-24605 JJ denotes anti-CD3
T20846 24591-24596 VBG denotes using
T20845 24582-24590 NN denotes ligation
T20844 24580-24581 -RRB- denotes )
T20843 24577-24580 NNP denotes TCR
T20842 24576-24577 -LRB- denotes (
T20841 24567-24575 NN denotes receptor
T20840 24562-24566 NN denotes cell
T20839 24560-24561 NNP denotes T
T20838 24557-24559 IN denotes as
T20837 24552-24556 RB denotes well
T20836 24549-24551 RB denotes as
T20835 24540-24548 NNS denotes mitogens
T20834 24536-24539 CC denotes and
T20833 24515-24535 NNS denotes cytokines/chemokines
T20832 24512-24514 IN denotes of
T20831 24504-24511 NN denotes variety
T20830 24502-24503 DT denotes a
T20829 24499-24501 TO denotes to
T20828 24488-24498 VBG denotes responding
T20827 24483-24487 NNP denotes PBMC
T20826 24480-24482 NNP denotes RA
T20825 24477-24479 IN denotes in
T20824 24471-24476 NNP denotes IL-17
T20823 24468-24470 IN denotes of
T20822 24457-24467 NN denotes production
T20821 24451-24456 NN denotes vitro
T20820 24448-24450 IN denotes in
T20819 24444-24447 DT denotes the
T20818 24431-24443 VBD denotes investigated
T20817 24421-24430 RB denotes therefore
T20816 24418-24420 PRP denotes We
T20815 24416-24417 . denotes .
T20814 24415-24416 NNP denotes ]
T20813 24410-24415 CD denotes 13,14
T20812 24409-24410 NNP denotes [
T20811 24398-24408 NN denotes production
T20810 24392-24397 JJ denotes IL-17
T20809 24383-24391 VB denotes regulate
T20808 24380-24382 TO denotes to
T20807 24374-24379 VBN denotes known
T20806 24369-24373 VBN denotes been
T20805 24364-24368 VBP denotes have
T20804 24362-24363 -RRB- denotes )
T20803 24357-24362 NN denotes IL-23
T20802 24353-24356 CC denotes and
T20801 24347-24352 NN denotes IL-15
T20800 24346-24347 -LRB- denotes (
T20799 24336-24345 NNS denotes cytokines
T20798 24331-24335 DT denotes some
T20797 24322-24330 IN denotes although
T20796 24320-24321 , denotes ,
T20795 24318-24320 NNP denotes RA
T20794 24315-24317 IN denotes in
T20793 24304-24314 NN denotes production
T20792 24298-24303 JJ denotes IL-17
T20791 24288-24297 VBP denotes stimulate
T20790 24283-24287 WDT denotes that
T20789 24276-24282 NNS denotes agents
T20788 24272-24275 DT denotes the
T20787 24269-24271 IN denotes on
T20786 24259-24268 JJ denotes available
T20785 24254-24258 NNS denotes data
T20784 24250-24253 JJ denotes few
T20783 24246-24249 RB denotes yet
T20782 24243-24245 RB denotes as
T20781 24239-24242 VBP denotes are
T20780 24233-24238 EX denotes There
T20779 24231-24232 . denotes .
T20778 24230-24231 NNP denotes ]
T20777 24222-24230 CD denotes 12,28,29
T20776 24221-24222 NNP denotes [
T20775 24215-24220 NN denotes vitro
T20774 24212-24214 IN denotes in
T20773 24209-24211 NN denotes E2
T20772 24195-24208 NN denotes prostaglandin
T20771 24192-24194 IN denotes as
T20770 24187-24191 RB denotes well
T20769 24184-24186 RB denotes as
T20768 24182-24183 CD denotes 6
T20767 24177-24181 NN denotes gene
T20766 24159-24176 JJ denotes factor-stimulated
T20765 24150-24158 NN denotes necrosis
T20764 24144-24149 NN denotes tumor
T20763 24140-24143 CC denotes and
T20762 24135-24139 NNP denotes IL-8
T20761 24133-24134 , denotes ,
T20760 24129-24133 NNP denotes IL-6
T20759 24126-24128 IN denotes as
T20758 24121-24125 JJ denotes such
T20757 24111-24120 NNS denotes cytokines
T20756 24103-24110 JJ denotes several
T20755 24095-24102 VB denotes secrete
T20754 24092-24094 TO denotes to
T20753 24079-24091 NNS denotes synoviocytes
T20752 24068-24078 JJ denotes rheumatoid
T20751 24057-24067 VBZ denotes stimulates
T20750 24051-24056 NNP denotes IL-17
T20749 24049-24050 , denotes ,
T20748 24042-24049 NN denotes example
T20747 24038-24041 IN denotes For
T20746 24036-24037 . denotes .
T20745 24030-24036 NNS denotes joints
T20744 24026-24029 DT denotes the
T20743 24023-24025 IN denotes in
T20742 24017-24022 NNS denotes cells
T20741 24011-24016 JJ denotes other
T20740 24002-24010 VBP denotes activate
T20739 23997-24001 RB denotes also
T20738 23991-23996 WDT denotes which
T20737 23989-23990 , denotes ,
T20736 23979-23989 NNS denotes chemokines
T20735 23975-23978 CC denotes and
T20734 23965-23974 NNS denotes cytokines
T20733 23949-23964 JJ denotes proinflammatory
T20732 23946-23948 IN denotes of
T20731 23938-23945 NN denotes variety
T20730 23936-23937 DT denotes a
T20729 23928-23935 VB denotes produce
T20728 23922-23927 MD denotes might
T20727 23915-23921 NNS denotes joints
T20726 23912-23914 NNP denotes RA
T20725 23903-23911 JJ denotes inflamed
T20724 23900-23902 IN denotes in
T20723 23894-23899 NNS denotes cells
T20722 23886-23893 IN denotes between
T20721 23874-23885 NN denotes interaction
T20720 23866-23873 JJ denotes complex
T20719 23864-23865 DT denotes A
T20718 23862-23863 . denotes .
T20717 23861-23862 NNP denotes ]
T20716 23859-23861 CD denotes 27
T20715 23858-23859 NNP denotes [
T20714 23852-23857 NN denotes model
T20713 23842-23851 NN denotes arthritis
T20712 23825-23841 JJ denotes collagen-induced
T20711 23823-23824 DT denotes a
T20710 23820-23822 IN denotes in
T20709 23811-23819 NN denotes collagen
T20708 23808-23810 NNP denotes II
T20707 23803-23807 NN denotes type
T20706 23791-23802 VBG denotes recognizing
T20705 23785-23790 NNS denotes cells
T20704 23783-23784 NNP denotes T
T20703 23780-23782 IN denotes by
T20702 23770-23779 VBN denotes augmented
T20655 23531-23536 NNS denotes cells
T20654 23529-23530 NNP denotes T
T20653 23527-23528 CD denotes +
T20652 23524-23527 NNP denotes CD4
T20651 23514-23523 VBN denotes activated
T20650 23511-23513 IN denotes by
T20649 23504-23510 RB denotes mainly
T20648 23495-23503 VBN denotes produced
T20647 23492-23494 VBZ denotes is
T20646 23486-23491 NNP denotes IL-17
T20645 23484-23485 . denotes .
T20644 23471-23484 NN denotes proliferation
T20643 23462-23470 JJ denotes cellular
T20642 23459-23461 TO denotes to
T20641 23454-23458 IN denotes than
T20640 23447-23453 RB denotes rather
T20639 23438-23446 NN denotes activity
T20638 23429-23437 JJ denotes cellular
T20637 23419-23428 VBN denotes increased
T20636 23416-23418 TO denotes to
T20635 23412-23415 JJ denotes due
T20634 23409-23411 VB denotes be
T20633 23403-23408 MD denotes might
T20632 23397-23402 NNP denotes IL-17
T20631 23394-23396 IN denotes of
T20630 23381-23393 NN denotes upregulation
T20629 23376-23380 DT denotes this
T20628 23371-23375 IN denotes that
T20627 23369-23370 , denotes ,
T20626 23368-23369 -RRB- denotes )
T20625 23363-23368 VBN denotes shown
T20624 23359-23362 RB denotes not
T20623 23354-23358 NNS denotes data
T20622 23353-23354 -LRB- denotes (
T20621 23347-23352 NN denotes assay
T20620 23333-23346 NN denotes proliferation
T20619 23328-23332 NN denotes cell
T20618 23326-23327 DT denotes a
T20617 23323-23325 IN denotes by
T20616 23321-23322 , denotes ,
T20615 23316-23321 VBD denotes found
T20614 23313-23315 PRP denotes We
T20613 23311-23312 . denotes .
T20612 23305-23311 NN denotes manner
T20611 23290-23304 JJ denotes dose-dependent
T20610 23288-23289 DT denotes a
T20609 23285-23287 IN denotes in
T20608 23280-23284 NNP denotes PBMC
T20607 23277-23279 NNP denotes RA
T20928 25056-25066 NN denotes production
T20927 25050-25055 NN denotes IL-17
T20926 25044-25049 NN denotes vitro
T20925 25041-25043 IN denotes in
T20924 25031-25040 VBD denotes triggered
T20923 25025-25030 NNP denotes IL-15
T20922 25020-25024 WDT denotes that
T20921 25013-25019 NN denotes report
T20920 25006-25012 JJ denotes recent
T20919 25004-25005 DT denotes a
T20918 24999-25003 IN denotes with
T20606 23272-23276 IN denotes from
T20605 23261-23271 NN denotes production
T20604 23255-23260 NNP denotes IL-17
T20603 23245-23254 VBD denotes increased
T20602 23243-23244 , denotes ,
T20601 23235-23243 NN denotes receptor
T20600 23230-23234 NN denotes cell
T20599 23228-23229 NNP denotes T
T20598 23224-23227 DT denotes the
T20597 23216-23223 IN denotes through
T20596 23206-23215 VBG denotes signaling
T20595 23202-23205 IN denotes for
T20594 23192-23201 NN denotes anti-CD28
T20593 23191-23192 NN denotes /
T20592 23183-23191 JJ denotes anti-CD3
T20591 23180-23182 IN denotes as
T20590 23175-23179 RB denotes well
T20589 23172-23174 RB denotes as
T20588 23170-23171 , denotes ,
T20587 23162-23170 NNS denotes mitogens
T20586 23159-23161 IN denotes as
T20585 23155-23158 NNP denotes PHA
T20584 23153-23154 , denotes ,
T20583 23142-23153 NNS denotes experiments
T20582 23138-23141 PRP$ denotes our
T20581 23135-23137 IN denotes In
T20580 23133-23134 . denotes .
T20579 23132-23133 NNP denotes ]
T20578 23130-23132 CD denotes 25
T20577 23129-23130 NNP denotes [
T20576 23117-23128 NNS denotes individuals
T20575 23109-23116 JJ denotes healthy
T20574 23106-23108 IN denotes in
T20573 23094-23105 NN denotes stimulation
T20572 23084-23093 JJ denotes anti-CD28
T20571 23083-23084 NN denotes /
T20570 23075-23083 JJ denotes anti-CD3
T20569 23072-23074 IN denotes by
T20568 23063-23071 VBN denotes achieved
T20567 23060-23062 VB denotes be
T20566 23056-23059 MD denotes can
T20565 23045-23055 NN denotes production
T20564 23039-23044 JJ denotes IL-17
T20563 23036-23038 IN denotes of
T20562 23030-23035 NN denotes level
T20561 23022-23029 JJS denotes highest
T20560 23018-23021 DT denotes the
T20559 23009-23017 IN denotes although
T20558 23007-23008 , denotes ,
T20557 23005-23007 NNP denotes RA
T20556 23002-23004 IN denotes in
T20555 22991-23001 NN denotes production
T20554 22985-22990 JJ denotes IL-17
T20553 22975-22984 VBP denotes stimulate
T20552 22970-22974 WDT denotes that
T20551 22963-22969 NNS denotes agents
T20550 22959-22962 DT denotes the
T20549 22956-22958 IN denotes on
T20548 22946-22955 JJ denotes available
T20547 22941-22945 NNS denotes data
T20546 22937-22940 JJ denotes few
T20545 22933-22936 VBP denotes are
T20544 22927-22932 EX denotes there
T20543 22925-22926 , denotes ,
T20542 22918-22925 RB denotes However
T20541 22916-22917 . denotes .
T20540 22915-22916 NNP denotes ]
T20539 22913-22915 CD denotes 15
T20538 22912-22913 NNP denotes [
T20537 22906-22911 NN denotes fluid
T20536 22897-22905 JJ denotes synovial
T20535 22894-22896 NNP denotes OA
T20534 22891-22893 IN denotes in
T20533 22886-22890 IN denotes than
T20532 22880-22885 NN denotes fluid
T20531 22871-22879 JJ denotes synovial
T20530 22868-22870 NNP denotes RA
T20529 22865-22867 IN denotes in
T20528 22858-22864 JJR denotes higher
T20527 22855-22857 VB denotes be
T20526 22852-22854 TO denotes to
T20525 22846-22851 VBN denotes found
T20524 22841-22845 VBD denotes were
T20523 22835-22840 NNP denotes IL-17
T20522 22832-22834 IN denotes of
T20521 22825-22831 NNS denotes Levels
T20520 22823-22824 . denotes .
T20519 22819-22823 VBD denotes used
T20518 22816-22818 PRP denotes it
T20517 22808-22815 NN denotes pathway
T20516 22798-22807 VBG denotes signaling
T20515 22792-22797 WDT denotes which
T20514 22788-22791 CC denotes and
T20513 22786-22787 , denotes ,
T20512 22782-22786 NNP denotes PBMC
T20511 22779-22781 NNP denotes RA
T20510 22776-22778 IN denotes in
T20509 22766-22775 VBN denotes regulated
T20508 22763-22765 VBZ denotes is
T20507 22752-22762 NN denotes production
T20506 22746-22751 JJ denotes IL-17
T20505 22742-22745 WRB denotes how
T20504 22733-22741 VB denotes evaluate
T20503 22730-22732 TO denotes to
T20502 22724-22729 VBD denotes tried
T20501 22721-22723 PRP denotes we
T20500 22719-22720 , denotes ,
T20499 22712-22719 NNS denotes studies
T20498 22708-22711 PRP$ denotes our
T20497 22705-22707 IN denotes In
T20496 22703-22704 . denotes .
T20495 22693-22703 NNS denotes properties
T20494 22677-22692 JJ denotes proinflammatory
T20493 22672-22676 IN denotes with
T20492 22663-22671 NN denotes cytokine
T20491 22650-22662 JJ denotes cell-derived
T20490 22648-22649 NNP denotes T
T20489 22646-22647 DT denotes a
T20488 22643-22645 IN denotes as
T20487 22633-22642 VBN denotes described
T20486 22628-22632 VBN denotes been
T20485 22624-22627 VBZ denotes has
T20484 22621-22623 PRP denotes it
T20483 22613-22620 IN denotes because
T20482 22603-22612 VBG denotes appealing
T20481 22600-22602 VBZ denotes is
T20480 22594-22599 NNP denotes IL-17
T20479 22592-22593 , denotes ,
T20478 22585-22592 NN denotes respect
T20477 22580-22584 DT denotes this
T20476 22577-22579 IN denotes In
T20475 22575-22576 . denotes .
T20474 22565-22575 NN denotes importance
T20473 22561-22564 PRP$ denotes its
T20472 22553-22560 VBN denotes limited
T20471 22549-22552 VBZ denotes has
T20470 22539-22548 NNS denotes cytokines
T20469 22526-22538 JJ denotes cell-derived
T20468 22524-22525 NNP denotes T
T20467 22521-22523 IN denotes of
T20466 22516-22520 NN denotes lack
T20465 22512-22515 DT denotes the
T20464 22510-22511 , denotes ,
T20463 22498-22510 NN denotes inflammation
T20462 22489-22497 JJ denotes synovial
T20461 22478-22488 JJ denotes rheumatoid
T20460 22475-22477 IN denotes of
T20459 22462-22474 NN denotes augmentation
T20458 22458-22461 DT denotes the
T20457 22455-22457 IN denotes in
T20456 22450-22454 NN denotes role
T20455 22448-22449 DT denotes a
T20454 22443-22447 VB denotes have
T20453 22439-22442 MD denotes may
T20452 22433-22438 NNS denotes cells
T20451 22431-22432 NNP denotes T
T20450 22422-22430 IN denotes Although
T20449 22420-22421 . denotes .
T20448 22419-22420 NNP denotes ]
T20447 22417-22419 CD denotes 24
T20446 22416-22417 NNP denotes [
T20445 22407-22415 NN denotes synovium
T20444 22404-22406 NNP denotes RA
T20443 22401-22403 IN denotes in
T20442 22394-22400 VB denotes detect
T20441 22391-22393 TO denotes to
T20440 22381-22390 JJ denotes difficult
T20701 23756-23769 RB denotes significantly
T20700 23752-23755 VBD denotes was
T20699 23741-23751 NN denotes production
T20698 23735-23740 JJ denotes IL-17
T20697 23733-23734 , denotes ,
T20696 23725-23733 NN denotes addition
T20695 23722-23724 IN denotes In
T20694 23720-23721 . denotes .
T20693 23719-23720 NNP denotes ]
T20692 23717-23719 CD denotes 14
T20691 23716-23717 NNP denotes [
T20690 23706-23715 NN denotes infection
T20689 23696-23705 JJ denotes pulmonary
T20688 23682-23695 JJ denotes Gram-negative
T20687 23679-23681 IN denotes in
T20686 23669-23678 NN denotes mechanism
T20685 23658-23668 VBG denotes triggering
T20684 23652-23657 JJ denotes IL-23
T20683 23649-23651 DT denotes an
T20682 23645-23648 IN denotes via
T20681 23639-23644 NNS denotes cells
T20680 23637-23638 NNP denotes T
T20679 23635-23636 CD denotes +
T20678 23632-23635 CD denotes CD8
T20677 23629-23631 IN denotes by
T20676 23620-23628 VBN denotes produced
T20675 23617-23619 VB denotes be
T20674 23612-23616 RB denotes also
T20673 23608-23611 MD denotes can
T20672 23605-23607 PRP denotes it
T20671 23603-23604 , denotes ,
T20670 23596-23603 RB denotes However
T20669 23594-23595 . denotes .
T20668 23593-23594 NNP denotes ]
T20667 23591-23593 CD denotes 26
T20666 23590-23591 NNP denotes [
T20665 23580-23589 NN denotes phenotype
T20664 23576-23579 JJ denotes Th2
T20663 23572-23575 DT denotes the
T20662 23568-23571 RB denotes not
T20661 23566-23567 , denotes ,
T20660 23561-23566 NNS denotes cells
T20659 23553-23560 JJ denotes Th1/Th0
T20658 23549-23552 IN denotes for
T20657 23538-23548 RB denotes especially
T20656 23536-23537 , denotes ,
T20439 22374-22380 VBN denotes proved
T20438 22368-22373 RB denotes often
T20437 22363-22367 VBP denotes have
T20436 22361-22362 , denotes ,
T20435 22349-22361 NN denotes interferon-γ
T20434 22345-22348 CC denotes and
T20433 22340-22344 NN denotes IL-4
T20432 22329-22339 RB denotes especially
T20431 22327-22328 , denotes ,
T20430 22318-22327 NNS denotes cytokines
T20429 22305-22317 JJ denotes cell-derived
T20428 22303-22304 NNP denotes T
T20427 22299-22302 DT denotes the
T20426 22291-22298 IN denotes whereas
T20425 22289-22290 , denotes ,
T20424 22281-22289 NN denotes synovium
T20423 22270-22280 JJ denotes rheumatoid
T20422 22267-22269 IN denotes in
T20421 22258-22266 JJ denotes abundant
T20420 22254-22257 VBP denotes are
T20419 22248-22253 NN denotes TNF-α
T20418 22244-22247 CC denotes and
T20417 22239-22243 NN denotes IL-1
T20416 22236-22238 IN denotes as
T20415 22231-22235 JJ denotes such
T20414 22221-22230 NNS denotes cytokines
T20413 22205-22220 JJ denotes Proinflammatory
T20412 22203-22204 . denotes .
T20411 22202-22203 NNP denotes ]
T20410 22200-22202 CD denotes 23
T20409 22199-22200 NNP denotes [
T20408 22193-22198 NNS denotes cells
T20407 22181-22192 NN denotes mononuclear
T20406 22178-22180 IN denotes by
T20405 22165-22177 NN denotes infiltration
T20404 22157-22164 JJ denotes intense
T20403 22154-22156 DT denotes an
T20402 22150-22153 CC denotes and
T20401 22144-22149 NNS denotes cells
T20400 22137-22143 NN denotes lining
T20399 22128-22136 JJ denotes synovial
T20398 22125-22127 IN denotes of
T20397 22113-22124 NN denotes hyperplasia
T20396 22110-22112 IN denotes by
T20395 22096-22109 VBN denotes characterized
T20394 22093-22095 VBZ denotes is
T20393 22090-22092 NNP denotes RA
T20392 22088-22089 . denotes .
T20391 22087-22088 NNP denotes ]
T20390 22083-22087 CD denotes 5,22
T20389 22082-22083 NNP denotes [
T20388 22071-22081 NNS denotes properties
T20387 22055-22070 JJ denotes proinflammatory
T20386 22050-22054 IN denotes with
T20385 22042-22049 NN denotes product
T20384 22037-22041 NN denotes cell
T20383 22035-22036 NNP denotes T
T20382 22033-22034 DT denotes a
T20381 22030-22032 IN denotes as
T20380 22020-22029 VBN denotes described
T20379 22014-22019 JJ denotes first
T20378 22010-22013 VBD denotes was
T20377 22004-22009 NNP denotes IL-17
T16660 21990-21991 . denotes .
T16659 21988-21990 NNP denotes RA
T16658 21983-21987 IN denotes with
T16657 21974-21982 NNS denotes patients
T16656 21969-21973 IN denotes from
T16655 21964-21968 NNP denotes PBMC
T16654 21954-21963 VBN denotes activated
T16653 21951-21953 IN denotes by
T16652 21940-21950 NN denotes production
T16651 21934-21939 JJ denotes IL-17
T16650 21931-21933 IN denotes in
T16649 21923-21930 NN denotes pathway
T16648 21913-21922 VBG denotes signaling
T16647 21899-21912 JJ denotes intracellular
T16646 21894-21898 JJ denotes main
T16645 21890-21893 DT denotes the
T16644 21887-21889 VBZ denotes is
T16643 21881-21886 NNP denotes NF-κB
T16620 21752-21754 IN denotes In
T16619 21750-21751 . denotes .
T16618 21749-21750 -RRB- denotes )
T16617 21747-21749 CD denotes 7c
T16616 21742-21746 NNP denotes Fig.
T16615 21741-21742 -LRB- denotes (
T16614 21736-21740 NN denotes time
T16613 21731-21735 JJ denotes same
T16612 21727-21730 DT denotes the
T16611 21724-21726 IN denotes at
T16610 21719-21723 NNP denotes PDTC
T16609 21715-21718 CC denotes and
T16608 21706-21714 NNP denotes LY294002
T16607 21703-21705 IN denotes by
T16606 21697-21702 JJ denotes IκB-α
T16605 21694-21696 IN denotes of
T16604 21682-21693 NN denotes degradation
T16603 21679-21681 IN denotes of
T16602 21668-21678 NN denotes inhibition
T16601 21661-21667 VBD denotes showed
T16600 21655-21660 JJ denotes IκB-α
T16599 21651-21654 IN denotes for
T16598 21642-21650 VBG denotes blotting
T16597 21634-21641 JJ denotes Western
T16596 21632-21633 . denotes .
T16595 21631-21632 -RRB- denotes )
T16594 21629-21631 CD denotes 7c
T16593 21624-21628 NNP denotes Fig.
T16592 21623-21624 -LRB- denotes (
T16591 21614-21622 NN denotes promoter
T16590 21608-21613 NNP denotes IL-17
T16589 21604-21607 DT denotes the
T16588 21601-21603 IN denotes in
T16587 21592-21600 NN denotes activity
T16586 21580-21591 JJ denotes DNA-binding
T16585 21574-21579 NNP denotes NF-κB
T16584 21568-21573 NN denotes block
T16583 21561-21567 NNS denotes agents
T16582 21556-21560 DT denotes Both
T16581 21554-21555 . denotes .
T16580 21550-21554 NNP denotes PDTC
T16579 21546-21549 CC denotes and
T16578 21537-21545 CD denotes LY294002
T16577 21532-21536 DT denotes both
T16576 21527-21531 IN denotes with
T16575 21517-21526 NN denotes treatment
T16574 21511-21516 IN denotes after
T16573 21502-21510 NN denotes activity
T16572 21494-21501 JJ denotes binding
T16571 21488-21493 JJ denotes NF-κB
T16570 21484-21487 DT denotes the
T16569 21474-21483 VB denotes determine
T16568 21471-21473 TO denotes to
T16567 21466-21470 NNP denotes EMSA
T16566 21456-21465 VBD denotes performed
T16565 21453-21455 PRP denotes we
T16564 21451-21452 , denotes ,
T16563 21446-21451 NN denotes NF-κB
T16562 21442-21445 CC denotes and
T16561 21433-21441 NN denotes activity
T16560 21428-21432 JJ denotes PI3K
T16559 21420-21427 IN denotes between
T16558 21415-21419 NN denotes link
T16557 21411-21414 DT denotes the
T16556 21403-21410 VB denotes confirm
T16555 21400-21402 TO denotes To
T16554 21398-21399 . denotes .
T16553 21397-21398 -RRB- denotes )
T16552 21395-21397 CD denotes 7b
T16551 21390-21394 NNP denotes Fig.
T16550 21389-21390 -LRB- denotes (
T16549 21384-21388 NNP denotes PBMC
T16548 21381-21383 NNP denotes RA
T16547 21378-21380 IN denotes in
T16546 21373-21377 DT denotes that
T16545 21368-21372 IN denotes than
T16544 21360-21367 JJ denotes intense
T16543 21355-21359 JJR denotes less
T16542 21351-21354 VBD denotes was
T16541 21341-21350 JJ denotes anti-CD28
T16540 21336-21340 CC denotes plus
T16539 21327-21335 JJ denotes anti-CD3
T16538 21324-21326 IN denotes by
T16537 21313-21323 NN denotes activation
T16536 21307-21312 JJ denotes NF-κB
T16535 21304-21306 IN denotes of
T16534 21297-21303 NN denotes degree
T16533 21293-21296 DT denotes the
T16532 21289-21292 CC denotes but
T16531 21287-21288 , denotes ,
T16530 21279-21287 VBN denotes observed
T16529 21275-21278 VBD denotes was
T16528 21267-21274 NN denotes pattern
T16527 21262-21266 JJ denotes same
T16526 21258-21261 DT denotes the
T16525 21253-21257 NNP denotes PBMC
T16524 21246-21252 JJ denotes normal
T16523 21243-21245 IN denotes In
T16522 21241-21242 . denotes .
T16521 21240-21241 -RRB- denotes )
T16520 21239-21240 CD denotes 5
T16519 21234-21238 NN denotes lane
T16518 21233-21234 -LRB- denotes (
T16517 21227-21232 NNP denotes c-Rel
T16516 21224-21226 IN denotes in
T16515 21220-21223 RB denotes not
T16514 21218-21219 -RRB- denotes )
T16513 21217-21218 CD denotes 4
T16512 21213-21216 CC denotes and
T16511 21211-21212 CD denotes 3
T16510 21205-21210 NNS denotes lanes
T16509 21204-21205 -LRB- denotes (
T16508 21200-21203 CD denotes p50
T16507 21196-21199 CC denotes and
T16506 21192-21195 CD denotes p65
T16505 21189-21191 IN denotes in
T16504 21183-21188 NNS denotes bands
T16503 21175-21182 VBN denotes shifted
T16502 21162-21174 VBD denotes demonstrated
T16501 21156-21161 NN denotes assay
T16500 21145-21155 NN denotes supershift
T16499 21143-21144 DT denotes A
T16498 21141-21142 . denotes .
T16497 21140-21141 -RRB- denotes )
T16496 21139-21140 CD denotes 1
T16495 21134-21138 NN denotes lane
T16494 21133-21134 -LRB- denotes (
T16493 21124-21132 NNS denotes controls
T16492 21121-21123 IN denotes of
T16491 21116-21120 DT denotes that
T16490 21111-21115 IN denotes with
T16489 21100-21110 NN denotes comparison
T16488 21097-21099 IN denotes in
T16487 21087-21096 NNS denotes promoters
T16486 21081-21086 NNP denotes IL-17
T16485 21078-21080 TO denotes to
T16484 21072-21077 NN denotes NF-κB
T16483 21069-21071 IN denotes of
T16482 21061-21068 JJ denotes binding
T16481 21051-21060 VBN denotes increased
T16480 21038-21050 VBD denotes demonstrated
T16479 21036-21037 -RRB- denotes )
T16478 21035-21036 CD denotes 2
T16477 21030-21034 NN denotes lane
T16476 21029-21030 -LRB- denotes (
T16475 21019-21028 JJ denotes anti-CD28
T16474 21014-21018 CC denotes plus
T16473 21005-21013 JJ denotes anti-CD3
T16472 21000-21004 IN denotes with
T16471 20989-20999 VBD denotes stimulated
T16470 20984-20988 NNP denotes PBMC
T16469 20981-20983 NNP denotes RA
T16468 20976-20980 IN denotes from
T16467 20967-20975 NNS denotes extracts
T16466 20959-20966 JJ denotes nuclear
T16465 20957-20958 , denotes ,
T16464 20955-20957 CD denotes 7a
T16463 20950-20954 NNP denotes Fig.
T16462 20947-20949 IN denotes in
T16461 20941-20946 VBN denotes shown
T16460 20938-20940 IN denotes As
T16459 20936-20937 . denotes .
T16458 20931-20936 NNP denotes IL-17
T16457 20928-20930 IN denotes of
T16456 20918-20927 NNS denotes promoters
T16455 20914-20917 DT denotes the
T16454 20911-20913 IN denotes in
T16453 20905-20910 NNS denotes sites
T16452 20893-20904 NN denotes recognition
T16451 20887-20892 NN denotes NF-κB
T16450 20884-20886 IN denotes of
T16449 20882-20883 -RRB- denotes )
T16448 20878-20882 NNP denotes EMSA
T16447 20877-20878 -LRB- denotes (
T16446 20871-20876 NN denotes assay
T16445 20856-20870 NN denotes mobility-shift
T16444 20840-20855 JJ denotes electrophoretic
T16443 20837-20839 DT denotes an
T16442 20827-20836 VBD denotes performed
T16441 20824-20826 PRP denotes we
T16440 20822-20823 , denotes ,
T16439 20812-20822 NN denotes expression
T16438 20806-20811 NNP denotes IL-17
T16437 20797-20805 VBG denotes inducing
T16436 20793-20796 IN denotes for
T16435 20781-20792 JJ denotes responsible
T16434 20777-20780 CC denotes and
T16433 20775-20776 , denotes ,
T16432 20770-20775 NNP denotes IL-15
T16431 20766-20769 CC denotes and
T16430 20762-20765 NNP denotes PHA
T16429 20760-20761 , denotes ,
T16428 20759-20760 DT denotes A
T16427 20746-20758 JJ denotes concanavalin
T16426 20744-20745 , denotes ,
T16425 20735-20744 JJ denotes anti-CD28
T16424 20730-20734 CC denotes plus
T16423 20721-20729 JJ denotes anti-CD3
T16422 20718-20720 IN denotes by
T16421 20708-20717 VBN denotes activated
T16420 20700-20707 NN denotes pathway
T16419 20690-20699 VBG denotes signaling
T16418 20676-20689 JJ denotes intracellular
T16417 20672-20675 DT denotes the
T16416 20664-20671 RB denotes further
T16415 20652-20663 VB denotes investigate
T16414 20649-20651 TO denotes To
T16413 20642-20648 NN denotes region
T16412 20633-20641 NN denotes promoter
T16411 20627-20632 NNP denotes IL-17
T16410 20623-20626 DT denotes the
T16409 20620-20622 IN denotes in
T16408 20612-20619 NN denotes pathway
T16407 20610-20611 -RRB- denotes )
T16406 20606-20610 NN denotes AP-1
T16405 20605-20606 -LRB- denotes (
T16402 20581-20584 CC denotes and
T16401 20575-20580 NN denotes NF-κB
T16400 20571-20574 DT denotes the
T16399 20568-20570 IN denotes of
T16398 20557-20567 NNP denotes Activation
T16642 21876-21880 IN denotes that
T16641 21862-21875 VBG denotes demonstrating
T16640 21860-21861 , denotes ,
T16639 21859-21860 -RRB- denotes )
T16638 21854-21859 VBN denotes shown
T16637 21850-21853 RB denotes not
T16636 21845-21849 NNS denotes data
T16635 21844-21845 -LRB- denotes (
T16634 21834-21843 JJ denotes anti-CD28
T16633 21829-21833 CC denotes plus
T16632 21820-21828 JJ denotes anti-CD3
T16631 21815-21819 IN denotes with
T16630 21803-21814 NN denotes stimulation
T16629 21800-21802 IN denotes by
T16628 21790-21799 VBN denotes activated
T16627 21786-21789 RB denotes not
T16626 21782-21785 VBD denotes was
T16625 21774-21781 NN denotes pathway
T16624 21769-21773 NNP denotes AP-1
T16623 21765-21768 DT denotes the
T16622 21763-21764 , denotes ,
T16621 21755-21763 NN denotes contrast
T16404 20595-20604 NN denotes protein-1
T16403 20585-20594 NN denotes activator
T15404 20554-20555 . denotes .
T15403 20553-20554 -RRB- denotes )
T15402 20548-20553 VBN denotes shown
T15401 20544-20547 RB denotes not
T15400 20539-20543 NNS denotes data
T15399 20538-20539 -LRB- denotes (
T15398 20529-20537 NNP denotes LY294002
T15397 20526-20528 IN denotes by
T15396 20523-20525 IN denotes as
T15395 20518-20522 RB denotes well
T15394 20515-20517 RB denotes as
T15393 20510-20514 NNP denotes PDTC
T15392 20506-20509 CC denotes and
T15391 20495-20505 NN denotes wortmannin
T15390 20492-20494 IN denotes by
T15389 20481-20491 NN denotes inhibition
T15388 20478-20480 DT denotes an
T15387 20474-20477 VBD denotes was
T15386 20468-20473 WDT denotes which
T15385 20466-20467 , denotes ,
T15384 20458-20466 JJ denotes anti-CD3
T15383 20453-20457 IN denotes with
T15382 20447-20452 VBN denotes shown
T15381 20444-20446 IN denotes as
T15380 20440-20443 NNP denotes Akt
T15379 20425-20439 VBN denotes phosphorylated
T15378 20422-20424 IN denotes on
T15377 20415-20421 NN denotes effect
T15376 20410-20414 JJ denotes same
T15375 20406-20409 DT denotes the
T15374 20393-20405 VBD denotes demonstrated
T15373 20388-20392 RB denotes also
T15372 20382-20387 NNP denotes IL-15
T15371 20378-20381 CC denotes and
T15370 20376-20377 DT denotes A
T15369 20363-20375 NN denotes concanavalin
T15368 20361-20362 , denotes ,
T15367 20358-20361 NNP denotes PHA
T15366 20356-20357 . denotes .
T15365 20352-20356 NN denotes time
T15364 20341-20351 NN denotes incubation
T15363 20338-20340 IN denotes of
T15362 20327-20337 RB denotes regardless
T15361 20317-20326 JJ denotes unchanged
T15360 20308-20316 VBD denotes remained
T15359 20300-20307 JJ denotes β-actin
T15358 20296-20299 CC denotes and
T15357 20292-20295 NNP denotes Akt
T15356 20273-20291 JJ denotes non-phosphorylated
T15355 20271-20272 , denotes ,
T15354 20263-20271 NN denotes contrast
T15353 20260-20262 IN denotes In
T15352 20258-20259 . denotes .
T15351 20255-20258 NN denotes min
T15350 20251-20254 CD denotes 240
T15349 20247-20250 CD denotes 120
T15348 20244-20246 TO denotes to
T15347 20236-20243 VBG denotes lasting
T15346 20234-20235 , denotes ,
T15345 20231-20234 NN denotes min
T15344 20228-20230 CD denotes 60
T15343 20225-20227 IN denotes at
T15342 20220-20224 NN denotes peak
T15341 20218-20219 DT denotes a
T15340 20210-20217 VBD denotes reached
T15339 20208-20209 -RRB- denotes )
T15338 20207-20208 CD denotes 3
T15337 20202-20206 NN denotes lane
T15336 20201-20202 -LRB- denotes (
T15335 20192-20200 NNP denotes LY294002
T15334 20189-20191 IN denotes by
T15333 20178-20188 NN denotes inhibition
T15332 20175-20177 IN denotes of
T15331 20168-20174 NN denotes effect
T15330 20164-20167 DT denotes the
T15329 20160-20163 CC denotes and
T15328 20158-20159 , denotes ,
T15327 20157-20158 -RRB- denotes )
T15326 20156-20157 CD denotes 2
T15325 20151-20155 NN denotes lane
T15324 20150-20151 -LRB- denotes (
T15323 20140-20149 VBD denotes increased
T15322 20136-20139 NNP denotes Akt
T15321 20121-20135 VBN denotes phosphorylated
T15320 20119-20120 , denotes ,
T15319 20109-20119 NN denotes incubation
T15318 20106-20108 IN denotes of
T15317 20102-20105 NN denotes min
T15316 20099-20101 CD denotes 30
T15315 20093-20098 IN denotes after
T15314 20091-20092 , denotes ,
T15313 20084-20091 RB denotes However
T15312 20082-20083 . denotes .
T15311 20074-20082 VBN denotes observed
T15310 20070-20073 VBD denotes was
T15309 20066-20069 NNP denotes Akt
T15308 20051-20065 VBN denotes phosphorylated
T15307 20048-20050 IN denotes of
T15306 20040-20047 NNS denotes amounts
T15305 20036-20039 DT denotes the
T15304 20033-20035 IN denotes in
T15303 20022-20032 NN denotes difference
T15302 20019-20021 DT denotes no
T15301 20017-20018 , denotes ,
T15300 20016-20017 -RRB- denotes )
T15299 20014-20016 NNP denotes μM
T15298 20011-20013 CD denotes 20
T15297 20010-20011 -LRB- denotes (
T15296 20001-20009 NNP denotes LY294002
T15295 19998-20000 CC denotes or
T15294 19996-19997 -RRB- denotes )
T15293 19994-19996 NN denotes ml
T15292 19993-19994 NN denotes /
T15291 19991-19993 NN denotes μg
T15290 19988-19990 CD denotes 10
T15289 19987-19988 -LRB- denotes (
T15288 19978-19986 JJ denotes anti-CD3
T15287 19973-19977 IN denotes with
T15286 19962-19972 NN denotes incubation
T15285 19959-19961 IN denotes of
T15284 19955-19958 NN denotes min
T15283 19952-19954 CD denotes 10
T15282 19949-19951 IN denotes at
T15281 19947-19948 , denotes ,
T15280 19946-19947 CD denotes 6
T15279 19941-19945 NNP denotes Fig.
T15278 19938-19940 IN denotes in
T15277 19932-19937 VBN denotes shown
T15276 19929-19931 IN denotes As
T15275 19927-19928 . denotes .
T15274 19919-19927 VBG denotes blotting
T15273 19911-19918 JJ denotes western
T15272 19908-19910 IN denotes by
T15271 19904-19907 NNP denotes Akt
T15270 19901-19903 IN denotes of
T15269 19890-19900 NN denotes activation
T15268 19886-19889 DT denotes the
T15267 19876-19885 VBD denotes evaluated
T15266 19873-19875 PRP denotes we
T15265 19871-19872 , denotes ,
T15264 19864-19871 NN denotes pathway
T15263 19859-19863 NNP denotes PI3K
T15262 19855-19858 DT denotes the
T15261 19852-19854 IN denotes of
T15260 19842-19851 NNS denotes molecules
T15259 19833-19841 NN denotes effector
T15258 19822-19832 JJ denotes downstream
T15257 19812-19821 VB denotes determine
T15256 19809-19811 TO denotes To
T15255 19800-19808 JJ denotes anti-CD3
T15254 19797-19799 IN denotes by
T15253 19786-19796 NN denotes production
T15252 19780-19785 NN denotes IL-17
T15251 19777-19779 IN denotes on
T15250 19769-19776 NN denotes pathway
T15249 19756-19768 NN denotes transduction
T15248 19749-19755 NN denotes signal
T15247 19740-19748 NNP denotes PI3K/Akt
T15246 19737-19739 IN denotes of
T15245 19726-19736 NNP denotes Activation
T14674 19723-19724 . denotes .
T14673 19722-19723 -RRB- denotes )
T14672 19721-19722 CD denotes 5
T14671 19716-19720 NNP denotes Fig.
T14670 19715-19716 -LRB- denotes (
T14669 19710-19714 NNP denotes PDTC
T14668 19700-19709 NN denotes inhibitor
T14667 19694-19699 JJ denotes NF-κB
T14666 19690-19693 DT denotes the
T14665 19687-19689 IN denotes by
T14664 19683-19686 CC denotes and
T14663 19674-19682 NNP denotes LY294002
T14662 19664-19673 NN denotes inhibitor
T14661 19659-19663 NNP denotes PI3K
T14660 19655-19658 DT denotes the
T14659 19652-19654 IN denotes by
T14658 19642-19651 VBN denotes inhibited
T14657 19638-19641 VBD denotes was
T14656 19633-19637 DT denotes this
T14655 19631-19632 : denotes ;
T14654 19623-19631 JJ denotes anti-CD3
T14653 19618-19622 IN denotes with
T14652 19606-19617 NN denotes stimulation
T14651 19600-19605 IN denotes after
T14650 19588-19599 NNS denotes transcripts
T14649 19583-19587 NNP denotes mRNA
T14648 19577-19582 NNP denotes IL-17
T14647 19574-19576 IN denotes in
T14646 19565-19573 NN denotes increase
T14645 19550-19564 JJ denotes dose-dependent
T14644 19548-19549 DT denotes a
T14643 19539-19547 VBD denotes observed
T14642 19536-19538 PRP denotes We
T14623 19391-19396 NN denotes IL-17
T14622 19382-19390 JJ denotes enhanced
T14621 19374-19381 IN denotes whether
T14620 19370-19373 VB denotes see
T14619 19367-19369 TO denotes To
T14618 19362-19366 NNP denotes PBMC
T14617 19359-19361 NNP denotes RA
T14616 19356-19358 IN denotes in
T14615 19345-19355 NN denotes expression
T14614 19340-19344 NNP denotes mRNA
T14613 19334-19339 NNP denotes IL-17
T14273 19331-19332 . denotes .
T14272 19330-19331 -RRB- denotes )
T14271 19328-19330 CD denotes 4b
T14270 19323-19327 NNP denotes Fig.
T14269 19322-19323 -LRB- denotes (
T14027 17968-17971 CC denotes and
T14026 17957-17967 NNS denotes inhibitors
T14025 17944-17956 NN denotes transduction
T14024 17937-17943 NN denotes signal
T14023 17934-17936 IN denotes by
T14022 17923-17933 NN denotes production
T14021 17917-17922 NNP denotes IL-17
T14020 17914-17916 IN denotes of
T14019 17903-17913 NNP denotes Inhibition
T14217 18993-19003 NN denotes inhibition
T14216 18989-18992 DT denotes the
T14215 18985-18988 IN denotes for
T14214 18976-18984 NNP denotes LY294002
T14213 18972-18975 CC denotes and
T14212 18967-18971 NNP denotes PDTC
T14211 18964-18966 IN denotes of
T14210 18955-18963 NN denotes response
T14209 18950-18954 NN denotes dose
T14208 18946-18949 DT denotes the
T14207 18937-18945 VBD denotes observed
T14206 18934-18936 PRP denotes we
T14205 18932-18933 , denotes ,
T14204 18918-18932 NNS denotes concentrations
T14203 18913-18917 JJ denotes high
T14202 18910-18912 IN denotes at
T14201 18905-18909 NN denotes drug
T14200 18901-18904 DT denotes the
T14199 18898-18900 IN denotes by
T14198 18887-18897 NN denotes inhibition
T14197 18874-18886 JJ denotes non-specific
T14196 18871-18873 IN denotes of
T14195 18859-18870 NN denotes possibility
T14194 18855-18858 DT denotes the
T14193 18846-18854 VB denotes evaluate
T14192 18843-18845 TO denotes To
T14191 18841-18842 . denotes .
T14190 18840-18841 -RRB- denotes )
T14189 18839-18840 CD denotes 3
T14188 18834-18838 JJ denotes Fig.
T14187 18833-18834 -LRB- denotes (
T14186 18826-18832 NNS denotes levels
T14185 18820-18825 NN denotes IL-17
T14184 18817-18819 IN denotes on
T14183 18810-18816 NN denotes effect
T14182 18807-18809 DT denotes no
T14181 18803-18806 VBD denotes had
T14180 18795-18802 NNP denotes PD98059
T14179 18791-18794 CC denotes and
T14178 18781-18790 NN denotes rapamycin
T14177 18773-18780 IN denotes whereas
T14176 18771-18772 , denotes ,
T14175 18768-18771 VBD denotes did
T14174 18759-18767 CD denotes SB203580
T14173 18749-18758 NN denotes inhibitor
T14172 18745-18748 CD denotes p38
T14171 18743-18744 -RRB- denotes )
T14170 18739-18743 NNP denotes MAPK
T14169 18738-18739 -LRB- denotes (
T14168 18731-18737 NN denotes kinase
T14167 18723-18730 NN denotes protein
T14166 18705-18722 JJ denotes mitogen-activated
T14165 18701-18704 DT denotes the
T14164 18698-18700 IN denotes as
T14163 18693-18697 RB denotes well
T14162 18690-18692 RB denotes as
T14161 18680-18689 NN denotes secretion
T14160 18674-18679 NNP denotes IL-17
T14159 18670-18673 DT denotes the
T14158 18656-18669 VBD denotes downregulated
T14157 18651-18655 RB denotes also
T14156 18645-18650 NNP denotes FK506
T14155 18641-18644 CC denotes and
T14154 18639-18640 DT denotes A
T14153 18627-18638 VBP denotes cyclosporin
T14152 18616-18626 NNS denotes inhibitors
T14151 18604-18615 NN denotes calcineurin
T14150 18600-18603 DT denotes The
T14149 18598-18599 . denotes .
T14148 18597-18598 -RRB- denotes )
T14147 18585-18597 RB denotes respectively
T14146 18583-18584 , denotes ,
T14145 18582-18583 NNP denotes ]
T14144 18578-18582 CD denotes 0.05
T14143 18576-18577 VBD denotes <
T14142 18574-18575 NNP denotes P
T14141 18573-18574 NNP denotes [
T14140 18567-18572 NN denotes pg/ml
T14139 18565-18566 CD denotes 4
T14138 18563-18564 NN denotes ±
T14137 18560-18562 CD denotes 48
T14136 18556-18559 CC denotes and
T14135 18554-18555 NNP denotes ]
T14134 18549-18554 CD denotes 0.005
T14133 18547-18548 VBD denotes <
T14132 18545-18546 NNP denotes P
T14131 18544-18545 NNP denotes [
T14130 18538-18543 NN denotes pg/ml
T14129 18535-18537 CD denotes 10
T14128 18533-18534 NN denotes ±
T14127 18530-18532 CD denotes 38
T14126 18523-18529 CC denotes versus
T14125 18520-18522 CD denotes 19
T14124 18518-18519 NN denotes ±
T14123 18515-18517 CD denotes 98
T14122 18514-18515 -LRB- denotes (
T14121 18509-18513 NNP denotes PBMC
T14120 18506-18508 NNP denotes RA
T14119 18503-18505 IN denotes in
T14118 18492-18502 NN denotes production
T14117 18486-18491 NN denotes IL-17
T14116 18469-18485 JJ denotes anti-CD3-induced
T14115 18465-18468 DT denotes the
T14114 18455-18464 VBD denotes inhibited
T14113 18446-18454 RB denotes markedly
T14112 18441-18445 RB denotes also
T14111 18439-18440 , denotes ,
T14110 18435-18439 NNP denotes PI3K
T14109 18432-18434 IN denotes of
T14108 18422-18431 NN denotes inhibitor
T14107 18419-18421 DT denotes an
T14106 18416-18418 IN denotes as
T14105 18414-18415 , denotes ,
T14104 18404-18414 NN denotes wortmannin
T14103 18400-18403 CC denotes and
T14102 18391-18399 CD denotes LY294002
T14101 18389-18390 . denotes .
T14100 18388-18389 -RRB- denotes )
T14099 18384-18388 CD denotes 0.05
T14098 18382-18383 NNP denotes <
T14097 18380-18381 NNP denotes P
T14096 18378-18379 : denotes ;
T14095 18366-18378 RB denotes respectively
T14094 18364-18365 , denotes ,
T14093 18359-18364 NN denotes pg/ml
T14092 18356-18358 CD denotes 19
T14091 18354-18355 NN denotes ±
T14090 18351-18353 CD denotes 98
T14089 18344-18350 CC denotes versus
T14088 18341-18343 CD denotes 11
T14087 18339-18340 NN denotes ±
T14086 18336-18338 CD denotes 54
T14085 18332-18335 CC denotes and
T14084 18330-18331 CD denotes 5
T14083 18328-18329 NN denotes ±
T14082 18325-18327 CD denotes 38
T14081 18324-18325 -LRB- denotes (
T14080 18318-18323 RB denotes alone
T14079 18309-18317 JJ denotes anti-CD3
T14078 18304-18308 IN denotes with
T14077 18293-18303 NN denotes comparison
T14076 18290-18292 IN denotes in
T14075 18276-18289 NN denotes dexamethasone
T14074 18272-18275 CC denotes and
T14073 18267-18271 NNP denotes PDTC
T14072 18265-18266 , denotes ,
T14071 18256-18265 NN denotes inhibitor
T14070 18250-18255 JJ denotes NF-κB
T14069 18245-18249 IN denotes with
T14068 18232-18244 VBN denotes co-incubated
T14067 18227-18231 WRB denotes when
T14066 18218-18226 VBN denotes observed
T14065 18214-18217 VBD denotes was
T14064 18203-18213 NN denotes production
T14063 18197-18202 NN denotes IL-17
T14062 18180-18196 JJ denotes anti-CD3-induced
T14061 18177-18179 IN denotes in
T14060 18168-18176 NN denotes decrease
T14059 18156-18167 JJ denotes significant
T14058 18153-18155 DT denotes an
T14057 18151-18152 , denotes ,
T14056 18150-18151 CD denotes 3
T14055 18145-18149 NNP denotes Fig.
T14054 18142-18144 IN denotes in
T14053 18130-18141 VBN denotes illustrated
T14052 18127-18129 IN denotes As
T14051 18125-18126 . denotes .
T14050 18117-18125 VBN denotes involved
T14049 18112-18116 VBD denotes were
T14048 18103-18111 NNS denotes pathways
T14047 18090-18102 NN denotes transduction
T14046 18083-18089 NN denotes signal
T14045 18077-18082 WDT denotes which
T14044 18072-18076 VB denotes know
T14043 18069-18071 TO denotes to
T14042 18059-18068 JJ denotes important
T14041 18055-18058 VBD denotes was
T14040 18052-18054 PRP denotes it
T14039 18050-18051 , denotes ,
T14038 18046-18050 NNP denotes PBMC
T14037 18043-18045 NNP denotes RA
T14036 18040-18042 IN denotes in
T14035 18029-18039 NN denotes production
T14034 18023-18028 NN denotes IL-17
T14033 18013-18022 VBN denotes increased
T14032 18009-18012 DT denotes the
T14031 18000-18008 VBN denotes observed
T14030 17993-17999 VBG denotes Having
T14029 17987-17992 NNS denotes drugs
T14028 17972-17986 JJ denotes anti-rheumatic
T13109 17581-17587 NNS denotes levels
T13108 17577-17580 DT denotes the
T13107 17575-17576 -RRB- denotes )
T13106 17570-17575 NN denotes ng/ml
T13105 17567-17569 CD denotes 10
T13104 17566-17567 -LRB- denotes (
T13103 17560-17565 NNP denotes TGF-β
T13102 17557-17559 CC denotes or
T13101 17555-17556 -RRB- denotes )
T13100 17550-17555 NN denotes ng/ml
T13099 17547-17549 CD denotes 10
T13098 17546-17547 -LRB- denotes (
T13097 17540-17545 NN denotes IL-18
T13096 17538-17539 , denotes ,
T13095 17537-17538 -RRB- denotes )
T13094 17532-17537 NN denotes ng/ml
T13093 17529-17531 CD denotes 10
T13092 17528-17529 -LRB- denotes (
T13091 17522-17527 NNP denotes TNF-α
T13090 17520-17521 , denotes ,
T13089 17519-17520 -RRB- denotes )
T13087 17511-17513 CD denotes 10
T13086 17510-17511 -LRB- denotes (
T13085 17504-17509 NN denotes IL-1β
T13084 17499-17503 IN denotes with
T13083 17491-17498 IN denotes whereas
T13082 17489-17490 , denotes ,
T13081 17488-17489 -RRB- denotes )
T13080 17483-17488 NN denotes ng/ml
T13079 17480-17482 CD denotes 10
T13078 17479-17480 -LRB- denotes (
T13077 17473-17478 NNP denotes IL-15
T13076 17468-17472 IN denotes with
T13075 17456-17467 NN denotes stimulation
T13074 17450-17455 IN denotes after
T13073 17444-17449 NN denotes level
T13072 17438-17443 NNP denotes IL-17
T13071 17435-17437 IN denotes in
T13070 17426-17434 NN denotes increase
T13069 17423-17425 DT denotes an
T13068 17414-17422 VBD denotes detected
T13067 17411-17413 PRP denotes We
T13066 17409-17410 . denotes .
T13065 17399-17409 NN denotes production
T13064 17393-17398 NN denotes IL-17
T13063 17390-17392 IN denotes on
T13062 17379-17389 NNS denotes chemokines
T13061 17375-17378 CC denotes and
T14218 19004-19006 IN denotes of
T13060 17365-17374 NNS denotes cytokines
T13059 17357-17364 JJ denotes several
T13058 17354-17356 IN denotes of
T13057 17346-17353 NNS denotes effects
T13056 17342-17345 DT denotes the
T13055 17335-17341 VBD denotes tested
T13054 17332-17334 PRP denotes we
T13053 17330-17331 , denotes ,
T13052 17326-17330 NNP denotes PBMC
T13051 17316-17325 VBN denotes activated
T13050 17313-17315 IN denotes by
T13049 17304-17312 VBN denotes released
T13048 17294-17303 NNS denotes cytokines
T13047 17281-17293 JJ denotes inflammatory
T13046 17278-17280 IN denotes of
T13045 17270-17277 NNS denotes effects
T13044 17266-17269 DT denotes the
T13043 17257-17265 VB denotes evaluate
T13042 17254-17256 TO denotes To
T13041 17252-17253 . denotes .
T13040 17247-17252 NNS denotes cells
T13039 17245-17246 NNP denotes T
T13038 17240-17244 IN denotes from
T13037 17234-17239 NNP denotes IL-17
T13036 17231-17233 IN denotes of
T13035 17220-17230 NN denotes production
T13034 17216-17219 DT denotes the
T13033 17207-17215 VBN denotes affected
T13032 17202-17206 VB denotes have
T13031 17196-17201 MD denotes might
T13030 17184-17195 NNS denotes lymphocytes
T13029 17178-17183 JJ denotes other
T13028 17174-17177 CC denotes and
T13027 17162-17173 NNS denotes macrophages
T13026 17157-17161 IN denotes from
T13025 17148-17156 VBN denotes released
T13024 17138-17147 NNS denotes cytokines
T13023 17125-17137 JJ denotes inflammatory
T13022 17120-17124 DT denotes some
T13021 17118-17119 , denotes ,
T13020 17113-17118 NNS denotes cells
T13019 17111-17112 NNP denotes T
T13018 17108-17110 TO denotes to
T13017 17099-17107 NN denotes addition
T13016 17096-17098 IN denotes in
T13015 17090-17095 NNS denotes types
T13014 17085-17089 NN denotes cell
T13013 17077-17084 JJ denotes several
T13012 17069-17076 VBP denotes include
T13011 17064-17068 NNP denotes PBMC
T13010 17061-17063 NNP denotes RA
T13009 17053-17060 IN denotes Because
T13008 17042-17052 NNS denotes chemokines
T13007 17038-17041 CC denotes and
T13006 17028-17037 NNS denotes cytokines
T13005 17015-17027 JJ denotes inflammatory
T13004 17012-17014 IN denotes by
T13003 17007-17011 NNP denotes PBMC
T13002 17004-17006 NNP denotes RA
T13001 17001-17003 IN denotes in
T13000 16990-17000 NN denotes production
T12999 16984-16989 JJ denotes IL-17
T12998 16981-16983 IN denotes of
T12997 16970-16980 NN denotes Regulation
T14268 19313-19321 JJ denotes observed
T14267 19309-19312 RB denotes not
T14266 19304-19308 VBD denotes were
T14265 19289-19303 NNS denotes concentrations
T14264 19276-19288 JJ denotes experimental
T14263 19273-19275 IN denotes at
T14262 19262-19272 NNS denotes inhibitors
T14261 19253-19261 NN denotes chemical
T14260 19249-19252 DT denotes the
T14259 19246-19248 IN denotes by
T14258 19241-19245 NNP denotes PBMC
T14257 19238-19240 IN denotes on
T14256 19230-19237 NNS denotes effects
T14255 19220-19229 JJ denotes Cytotoxic
T14254 19218-19219 . denotes .
T14253 19208-19218 NN denotes inhibition
T14252 19205-19207 IN denotes of
T14251 19197-19204 NN denotes pattern
T14250 19192-19196 JJ denotes same
T14249 19188-19191 DT denotes the
T14248 19181-19187 VBD denotes showed
T14247 19172-19180 NNP denotes LY294002
T14246 19168-19171 CC denotes and
T14245 19163-19167 NNP denotes PDTC
T14244 19160-19162 TO denotes to
T14243 19151-19159 NN denotes addition
T14242 19148-19150 IN denotes in
T14241 19137-19147 NNS denotes inhibitors
T14240 19131-19136 JJ denotes other
T14239 19127-19130 DT denotes The
T14238 19125-19126 . denotes .
T14237 19124-19125 -RRB- denotes )
T14236 19122-19124 CD denotes 4a
T14235 19117-19121 NNP denotes Fig.
T14234 19116-19117 -LRB- denotes (
T14233 19105-19115 NNS denotes inhibitors
T14232 19096-19104 NN denotes chemical
T14231 19091-19095 IN denotes with
T14230 19080-19090 NN denotes production
T14229 19074-19079 JJ denotes IL-17
T14228 19071-19073 IN denotes of
T14227 19059-19070 NNS denotes inhibitions
T14226 19044-19058 JJ denotes dose-dependent
T14225 19039-19043 VBD denotes were
T14224 19033-19038 EX denotes There
T14223 19031-19032 . denotes .
T14222 19027-19031 NNP denotes PBMC
T14221 19024-19026 IN denotes in
T14220 19013-19023 NN denotes production
T14219 19007-19012 JJ denotes IL-17
T13188 17900-17901 . denotes .
T13187 17899-17900 -RRB- denotes )
T13186 17897-17899 CD denotes 2b
T13185 17892-17896 NNP denotes Fig.
T13184 17891-17892 -LRB- denotes (
T13183 17889-17890 -RRB- denotes )
T13182 17884-17889 NN denotes ng/ml
T13181 17881-17883 CD denotes 10
T13180 17880-17881 -LRB- denotes (
T13179 17873-17879 NNP denotes MIP-1β
T13178 17870-17872 CC denotes or
T13177 17868-17869 -RRB- denotes )
T13176 17863-17868 NN denotes ng/ml
T13175 17860-17862 CD denotes 10
T13174 17859-17860 -LRB- denotes (
T13173 17852-17858 NNP denotes MIP-1α
T13172 17850-17851 , denotes ,
T13171 17849-17850 -RRB- denotes )
T13170 17844-17849 NN denotes ng/ml
T13169 17841-17843 CD denotes 10
T13168 17840-17841 -LRB- denotes (
T13167 17835-17839 NN denotes IL-8
T13166 17830-17834 IN denotes with
T13165 17821-17829 VBN denotes observed
T13164 17817-17820 VBD denotes was
T13163 17812-17816 NN denotes none
T13162 17804-17811 IN denotes whereas
T13161 17802-17803 , denotes ,
T13160 17801-17802 -RRB- denotes )
T13159 17797-17801 CD denotes 0.05
T13158 17795-17796 NNP denotes <
T13157 17793-17794 NNP denotes P
T13156 17791-17792 : denotes ;
T13155 17779-17791 RB denotes respectively
T13154 17777-17778 , denotes ,
T13153 17772-17777 NN denotes pg/ml
T13152 17769-17771 CD denotes 11
T13151 17767-17768 NN denotes ±
T13150 17764-17766 CD denotes 31
T13149 17757-17763 CC denotes versus
T13148 17754-17756 CD denotes 10
T13147 17752-17753 NN denotes ±
T13146 17749-17751 CD denotes 50
T13145 17745-17748 CC denotes and
T13144 17742-17744 CD denotes 42
T13143 17740-17741 NN denotes ±
T13142 17737-17739 CD denotes 62
T13141 17736-17737 -LRB- denotes (
T13140 17727-17735 VBN denotes observed
T13139 17722-17726 VBD denotes were
T13138 17713-17721 NNS denotes proteins
T13137 17707-17712 NNP denotes IL-17
T13136 17704-17706 IN denotes of
T13135 17690-17703 NNS denotes upregulations
T13134 17678-17689 JJ denotes significant
T13133 17676-17677 , denotes ,
T13132 17675-17676 -RRB- denotes )
T13131 17670-17675 NN denotes ng/ml
T13130 17667-17669 CD denotes 10
T13129 17666-17667 -LRB- denotes (
T13128 17661-17665 NNP denotes IL-6
T13127 17658-17660 CC denotes or
T13126 17656-17657 -RRB- denotes )
T13125 17651-17656 NN denotes ng/ml
T13124 17648-17650 CD denotes 10
T13123 17647-17648 -LRB- denotes (
T13122 17641-17646 NNP denotes MCP-1
T13121 17636-17640 IN denotes with
T13120 17628-17635 VBN denotes treated
T13119 17623-17627 WRB denotes When
T13118 17621-17622 . denotes .
T13117 17620-17621 -RRB- denotes )
T13116 17618-17620 CD denotes 2a
T13115 17613-17617 NNP denotes Fig.
T13114 17612-17613 -LRB- denotes (
T13113 17602-17611 JJ denotes unchanged
T13112 17597-17601 VBD denotes were
T13111 17591-17596 NNP denotes IL-17
T13110 17588-17590 IN denotes in
T12190 16510-16514 DT denotes this
T12189 16507-16509 IN denotes of
T12188 16501-16506 NN denotes basis
T12187 16497-16500 DT denotes the
T12186 16494-16496 IN denotes On
T12185 16492-16493 . denotes .
T12184 16491-16492 -RRB- denotes )
T12183 16486-16491 VBN denotes shown
T12182 16482-16485 RB denotes not
T12181 16477-16481 NNS denotes data
T12180 16476-16477 -LRB- denotes (
T12179 16469-16475 NNS denotes levels
T12178 16463-16468 NNP denotes IL-17
T12177 16460-16462 IN denotes in
T12176 16451-16459 NN denotes increase
T12175 16436-16450 JJ denotes dose-dependent
T12174 16434-16435 DT denotes a
T12173 16427-16433 VBD denotes showed
T12172 16421-16426 WDT denotes which
T12171 16419-16420 , denotes ,
T12170 16409-16419 NN denotes activation
T12169 16404-16408 NN denotes cell
T12168 16402-16403 NNP denotes T
T12167 16400-16401 DT denotes a
T12166 16397-16399 IN denotes as
T12165 16395-16396 -RRB- denotes )
T12164 16393-16395 NN denotes ml
T12163 16392-16393 NN denotes /
T12162 16390-16392 NN denotes μg
T12161 16387-16389 CD denotes 10
T12160 16383-16386 CC denotes and
T12159 16381-16382 CD denotes 5
T12158 16379-16380 , denotes ,
T12157 16378-16379 CD denotes 1
T12156 16377-16378 -LRB- denotes (
T12155 16368-16376 JJ denotes anti-CD3
T12154 16365-16367 IN denotes of
T12153 16350-16364 NNS denotes concentrations
T12152 16340-16349 JJ denotes different
T12151 16337-16339 IN denotes of
T12150 16330-16336 NN denotes effect
T12149 16326-16329 DT denotes the
T12148 16313-16325 VBD denotes investigated
T12147 16310-16312 PRP denotes we
T12146 16308-16309 , denotes ,
T12145 16303-16308 NNS denotes cells
T12144 16301-16302 NNP denotes T
T12143 16291-16300 VBN denotes activated
T12142 16288-16290 IN denotes by
T12141 16281-16287 RB denotes mainly
T12140 16272-16280 VBN denotes produced
T12139 16269-16271 VB denotes be
T12138 16266-16268 TO denotes to
T12137 16258-16265 NNS denotes reports
T12136 16250-16257 JJR denotes earlier
T12135 16245-16249 IN denotes from
T12134 16239-16244 VBN denotes known
T12133 16231-16238 RB denotes already
T12132 16227-16230 VBD denotes was
T12131 16221-16226 NNP denotes IL-17
T12130 16213-16220 IN denotes Because
T12129 16209-16212 NNP denotes PHA
T12128 16205-16208 CC denotes and
T12127 16203-16204 , denotes ,
T12126 16194-16203 JJ denotes anti-CD28
T12125 16187-16193 CC denotes and/or
T12124 16178-16186 JJ denotes anti-CD3
T12123 16175-16177 IN denotes by
T12122 16172-16174 NNP denotes RA
T12121 16167-16171 IN denotes with
T12120 16158-16166 NNS denotes patients
T12119 16155-16157 IN denotes of
T12118 16150-16154 NNP denotes PBMC
T12117 16147-16149 IN denotes in
T12116 16136-16146 NN denotes production
T12115 16130-16135 JJ denotes IL-17
T12114 16120-16129 VBN denotes Increased
T12278 16967-16968 . denotes .
T12277 16966-16967 -RRB- denotes )
T12276 16962-16966 CD denotes 0.05
T12275 16960-16961 NNP denotes <
T12274 16958-16959 NNP denotes P
T12273 16956-16957 : denotes ;
T12272 16951-16956 NN denotes pg/ml
T12271 16949-16950 CD denotes 1
T12270 16947-16948 CD denotes ±
T12269 16943-16946 CD denotes 211
T12268 16936-16942 IN denotes versus
T12267 16933-16935 CD denotes 85
T12266 16931-16932 CD denotes ±
T12265 16927-16930 CD denotes 588
T12264 16926-16927 -LRB- denotes (
T12263 16916-16925 JJ denotes anti-CD28
T12262 16912-16915 CC denotes and
T12261 16903-16911 JJ denotes anti-CD3
T12260 16898-16902 IN denotes with
T12259 16893-16897 IN denotes than
T12258 16882-16892 JJ denotes pronounced
T12257 16877-16881 RBR denotes more
T12256 16873-16876 VBD denotes was
T12255 16862-16872 NN denotes production
T12254 16856-16861 NNP denotes IL-17
T12253 16846-16855 VBD denotes increased
T12252 16844-16845 , denotes ,
T12251 16841-16844 NNP denotes PHA
T12250 16838-16840 IN denotes as
T12249 16833-16837 JJ denotes such
T12248 16824-16832 NNS denotes mitogens
T12247 16819-16823 NN denotes cell
T12246 16817-16818 NNP denotes T
T12245 16812-16816 IN denotes with
T12244 16802-16811 VBN denotes incubated
T12243 16797-16801 WRB denotes when
T12242 16795-16796 , denotes ,
T12241 16784-16795 RB denotes Furthermore
T12240 16782-16783 . denotes .
T12239 16777-16782 RB denotes alone
T12238 16768-16776 JJ denotes anti-CD3
T12237 16763-16767 IN denotes than
T12236 16761-16762 -RRB- denotes )
T12235 16757-16761 VB denotes fold
T12234 16756-16757 : denotes -
T12233 16754-16756 SYM denotes .5
T12232 16749-16754 CD denotes 1.3-1
T12231 16735-16748 RB denotes approximately
T12230 16734-16735 -LRB- denotes (
T12229 16728-16733 JJ denotes IL-17
T12228 16723-16727 RBR denotes more
T12227 16714-16722 VBN denotes produced
T12226 16705-16713 JJ denotes anti-CD3
T12225 16701-16704 CC denotes and
T12224 16691-16700 JJ denotes anti-CD28
T12223 16688-16690 IN denotes of
T12222 16676-16687 NN denotes combination
T12221 16672-16675 DT denotes the
T12220 16668-16671 CC denotes and
T12219 16666-16667 , denotes ,
T12218 16658-16666 CD denotes 3.7-fold
T12217 16655-16657 TO denotes to
T12216 16652-16654 IN denotes up
T12215 16641-16651 NN denotes production
T12214 16635-16640 NN denotes IL-17
T12213 16623-16634 JJ denotes upregulated
T12212 16609-16622 RB denotes significantly
T12211 16600-16608 JJ denotes anti-CD3
T12210 16598-16599 , denotes ,
T12209 16597-16598 CD denotes 1
T12208 16591-16596 NNP denotes Table
T12207 16588-16590 IN denotes in
T12206 16582-16587 VBN denotes shown
T12205 16579-16581 IN denotes As
T12204 16577-16578 . denotes .
T12203 16569-16577 JJ denotes anti-CD3
T12202 16565-16568 IN denotes for
T12201 16551-16564 NN denotes concentration
T12200 16539-16550 NN denotes stimulation
T12199 16537-16538 DT denotes a
T12198 16534-16536 IN denotes as
T12197 16531-16533 NN denotes ml
T12196 16530-16531 NN denotes /
T12195 16528-16530 NN denotes μg
T12194 16525-16527 CD denotes 10
T12193 16519-16524 VBD denotes chose
T12192 16516-16518 PRP denotes we
T12191 16514-16515 , denotes ,
T11538 16014-16019 DT denotes those
T11537 16011-16013 IN denotes in
T11536 16006-16010 IN denotes than
T11535 16001-16005 NNP denotes PBMC
T11534 15998-16000 NNP denotes RA
T11533 15995-15997 IN denotes in
T11532 15988-15994 JJR denotes higher
T11531 15974-15987 RB denotes significantly
T11530 15970-15973 VBD denotes was
T11529 15966-15969 NNP denotes PHA
T11528 15963-15965 IN denotes by
T11527 15952-15962 VBN denotes stimulated
T11526 15941-15951 NN denotes production
T11525 15935-15940 NNP denotes IL-17
T11524 15931-15934 DT denotes the
T11523 15929-15930 , denotes ,
T11522 15928-15929 -RRB- denotes )
T11521 15916-15928 RB denotes respectively
T11520 15914-15915 , denotes ,
T11519 15909-15914 NN denotes pg/ml
T11518 15906-15908 CD denotes 10
T11517 15904-15905 NN denotes ±
T11516 15901-15903 CD denotes 43
T11515 15897-15900 CC denotes and
T11514 15894-15896 CD denotes 19
T11513 15892-15893 NN denotes ±
T11512 15889-15891 CD denotes 43
T11511 15887-15888 , denotes ,
T11510 15885-15887 CD denotes 31
T11509 15883-15884 NN denotes ±
T11508 15880-15882 CD denotes 62
T11507 15879-15880 -LRB- denotes (
T11506 15870-15878 NNS denotes controls
T11505 15863-15869 JJ denotes normal
T11504 15859-15862 CC denotes and
T11503 15856-15858 NNP denotes OA
T11502 15854-15855 , denotes ,
T11501 15852-15854 NNP denotes RA
T11500 15844-15851 IN denotes between
T11499 15834-15843 JJ denotes different
T11498 15830-15833 RB denotes not
T11497 15825-15829 VBD denotes were
T11496 15815-15824 NN denotes secretion
T11495 15809-15814 NNP denotes IL-17
T11494 15803-15808 JJ denotes basal
T11493 15800-15802 IN denotes of
T11492 15792-15799 NNS denotes amounts
T11491 15788-15791 DT denotes the
T11490 15779-15787 IN denotes Although
T11489 15777-15778 . denotes .
T11488 15776-15777 -RRB- denotes )
T11487 15775-15776 CD denotes 1
T11486 15770-15774 NNP denotes Fig.
T11485 15769-15770 -LRB- denotes (
T11484 15756-15768 NNS denotes supernatants
T11483 15748-15755 NN denotes culture
T11482 15744-15747 DT denotes the
T11481 15741-15743 IN denotes in
T11480 15730-15740 VBN denotes determined
T11479 15725-15729 RB denotes then
T11478 15720-15724 VBD denotes were
T11477 15713-15719 NNS denotes levels
T11476 15707-15712 NNP denotes IL-17
T11475 15705-15706 : denotes ;
T11474 15697-15705 NNS denotes controls
T11473 15690-15696 JJ denotes normal
T11472 15678-15689 JJ denotes age-matched
T11471 15674-15677 CC denotes and
T11470 15672-15673 , denotes ,
T11469 15670-15672 NNP denotes OA
T11468 15665-15669 IN denotes with
T11467 15656-15664 NNS denotes patients
T11466 15654-15655 , denotes ,
T11465 15652-15654 NNP denotes RA
T11464 15647-15651 IN denotes with
T11463 15638-15646 NNS denotes patients
T11462 15633-15637 IN denotes from
T11461 15631-15632 -RRB- denotes )
T11460 15629-15631 NN denotes ml
T11459 15628-15629 NN denotes /
T11458 15626-15628 NN denotes μg
T11457 15624-15625 CD denotes 5
T11456 15623-15624 -LRB- denotes (
T11455 15619-15622 NNP denotes PHA
T11454 15614-15618 IN denotes with
T11453 15605-15613 VBN denotes cultured
T11452 15601-15604 CC denotes and
T11434 15493-15498 NN denotes IL-17
T11568 16117-16118 . denotes .
T11567 16116-16117 -RRB- denotes )
T11566 16115-16116 NNP denotes ]
T11565 16110-16115 CD denotes 0.001
T11564 16108-16109 VBD denotes <
T11563 16106-16107 NNP denotes P
T11562 16105-16106 NNP denotes [
T11561 16099-16104 NN denotes pg/ml
T11560 16096-16098 CD denotes 29
T11559 16094-16095 CD denotes ±
T11558 16090-16093 CD denotes 241
T11557 16086-16089 CC denotes and
T11556 16084-16085 NNP denotes ]
T11555 16080-16084 CD denotes 0.05
T11554 16078-16079 VBD denotes <
T11553 16076-16077 NNP denotes P
T11552 16075-16076 NNP denotes [
T11551 16069-16074 VBN denotes pg/ml
T11550 16065-16068 CD denotes 211
T11549 16063-16064 CD denotes ±
T11548 16059-16062 CD denotes 463
T11547 16052-16058 IN denotes versus
T11546 16048-16051 CD denotes 295
T11545 16046-16047 CD denotes ±
T11544 16042-16045 CD denotes 768
T11543 16041-16042 -LRB- denotes (
T11542 16032-16040 NNS denotes controls
T11541 16028-16031 CC denotes and
T11540 16025-16027 NNP denotes OA
T10973 15295-15296 . denotes .
T10972 15294-15295 NNP denotes ]
T10971 15292-15294 CD denotes 21
T10970 15291-15292 NNP denotes [
T10969 15289-15290 -RRB- denotes )
T10968 15284-15289 NNS denotes cells
T10967 15279-15283 JJ denotes dead
T10966 15275-15278 CC denotes and
T10965 15268-15274 JJ denotes viable
T10964 15263-15267 DT denotes both
T10963 15260-15262 IN denotes of
T10962 15247-15259 NN denotes cells/number
T10961 15240-15246 JJ denotes viable
T10960 15237-15239 IN denotes of
T10959 15230-15236 NN denotes number
T10958 15229-15230 -LRB- denotes (
T10957 15227-15228 NN denotes ×
T10956 15223-15226 CD denotes 100
T10955 15215-15222 NN denotes formula
T10954 15211-15214 DT denotes the
T10953 15206-15210 IN denotes with
T10952 15195-15205 VBN denotes calculated
T10951 15191-15194 VBD denotes was
T10950 15181-15190 NN denotes viability
T10949 15176-15180 NN denotes cell
T10948 15165-15175 NN denotes percentage
T10947 15161-15164 DT denotes the
T10946 15157-15160 CC denotes and
T10945 15147-15156 VBN denotes harvested
T10944 15142-15146 VBD denotes were
T10943 15136-15141 NNS denotes cells
T10942 15132-15135 DT denotes the
T10941 15130-15131 , denotes ,
T10940 15125-15130 NNS denotes hours
T10939 15122-15124 CD denotes 24
T10938 15118-15121 IN denotes for
T10937 15107-15117 NN denotes incubation
T10936 15101-15106 IN denotes After
T10935 15099-15100 . denotes .
T10934 15094-15099 NNS denotes cells
T10933 15091-15093 IN denotes on
T10932 15080-15090 NNS denotes inhibitors
T10931 15077-15079 IN denotes of
T10930 15070-15076 NN denotes effect
T10929 15060-15069 JJ denotes cytotoxic
T10928 15053-15059 JJ denotes direct
T10927 15050-15052 IN denotes of
T10926 15040-15049 NN denotes potential
T10925 15036-15039 DT denotes the
T10924 15027-15035 VB denotes evaluate
T10923 15024-15026 TO denotes to
T10922 15019-15023 VBN denotes used
T10921 15015-15018 VBD denotes was
T10920 15008-15014 NN denotes method
T10919 14998-15007 NN denotes exclusion
T10918 14994-14997 NN denotes dye
T10917 14989-14993 JJ denotes blue
T10916 14982-14988 NN denotes trypan
T10915 14978-14981 DT denotes the
T10914 14976-14977 , denotes ,
T10913 14970-14976 NNS denotes assays
T10912 14960-14969 NN denotes viability
T10911 14955-14959 NN denotes cell
T10910 14951-14954 IN denotes For
T10909 14949-14950 -RRB- denotes )
T10908 14944-14949 NN denotes assay
T10907 14934-14943 NN denotes exclusion
T10906 14930-14933 NN denotes dye
T10905 14925-14929 JJ denotes blue
T10904 14918-14924 NNP denotes Trypan
T10903 14917-14918 -LRB- denotes (
T10902 14907-14916 NN denotes viability
T10901 14902-14906 NNP denotes Cell
T11076 15481-15482 . denotes .
T11075 15470-15481 JJ denotes significant
T11074 15459-15469 VBN denotes considered
T11073 15454-15458 VBD denotes were
T11072 15449-15453 CD denotes 0.05
T11071 15444-15448 IN denotes than
T11070 15439-15443 JJR denotes less
T11069 15432-15438 VBZ denotes values
T11068 15430-15431 NNP denotes P
T11067 15428-15429 . denotes .
T11066 15423-15428 NNS denotes pairs
T11065 15415-15422 VBN denotes matched
T11064 15411-15414 IN denotes for
T11063 15404-15410 JJS denotes t-test
T11062 15401-15403 POS denotes 's
T11061 15394-15401 NN denotes Student
T11060 15389-15393 IN denotes with
T11059 15379-15388 VBN denotes performed
T11058 15375-15378 VBD denotes was
T11057 15366-15374 NN denotes analysis
T11056 15354-15365 NNP denotes Statistical
T11055 15352-15353 . denotes .
T11054 15349-15352 NNP denotes SEM
T11053 15347-15348 VBP denotes ±
T11052 15341-15346 NNS denotes means
T11051 15338-15340 IN denotes as
T11050 15328-15337 VBN denotes expressed
T11049 15324-15327 VBP denotes are
T11048 15319-15323 NNS denotes Data
T11047 15310-15318 NN denotes analysis
T11046 15298-15309 NNP denotes Statistical
T10692 14899-14900 . denotes .
T10691 14898-14899 -RRB- denotes )
T10690 14895-14898 NNP denotes USA
T10689 14893-14894 , denotes ,
T10688 14891-14893 NNP denotes CA
T10687 14889-14890 , denotes ,
T10686 14885-14889 NNP denotes Cruz
T10685 14879-14884 NNP denotes Santa
T10684 14878-14879 -LRB- denotes (
T10683 14864-14877 NNP denotes Biotechnology
T10682 14859-14863 NNP denotes Cruz
T10681 14853-14858 NNP denotes Santa
T10680 14848-14852 IN denotes from
T10679 14843-14847 VBD denotes were
T10678 14837-14842 NNP denotes c-Rel
T10677 14833-14836 CC denotes and
T10676 14829-14832 CD denotes p65
T10675 14827-14828 , denotes ,
T10674 14824-14827 CD denotes p50
T10673 14815-14823 VBZ denotes subunits
T10672 14809-14814 NNP denotes NF-κB
T10671 14801-14808 IN denotes against
T10670 14790-14800 NNS denotes antibodies
T10669 14779-14789 NN denotes polyclonal
T10668 14772-14778 NN denotes Rabbit
T10667 14770-14771 . denotes .
T10666 14763-14770 NNS denotes screens
T10665 14750-14762 VBG denotes intensifying
T10664 14745-14749 IN denotes with
T10663 14743-14744 NNP denotes C
T10662 14742-14743 CD denotes °
T10661 14739-14742 CD denotes -70
T10660 14736-14738 IN denotes at
T10659 14731-14735 NN denotes film
T10658 14724-14730 NNP denotes X-OMAT
T10657 14718-14723 NNP denotes Kodak
T10656 14715-14717 TO denotes to
T10655 14707-14714 VBN denotes exposed
T10654 14703-14706 CC denotes and
T10653 14696-14702 NN denotes vacuum
T10652 14690-14695 IN denotes under
T10651 14684-14689 VBN denotes dried
T10650 14679-14683 VBD denotes were
T10649 14674-14678 NNP denotes Gels
T10648 14671-14673 NNP denotes V.
T10647 14667-14670 CD denotes 100
T10646 14664-14666 IN denotes at
T10645 14662-14663 -RRB- denotes )
T10644 14659-14662 CD denotes 8.0
T10643 14656-14658 NNP denotes pH
T10642 14655-14656 -LRB- denotes (
T10641 14648-14654 NN denotes buffer
T10640 14631-14647 NNP denotes Tris-borate-EDTA
T10639 14629-14630 CD denotes ×
T10638 14625-14628 CD denotes 0.5
T10637 14622-14624 IN denotes in
T10636 14617-14621 NNS denotes gels
T10635 14602-14616 NN denotes polyacrylamide
T10634 14600-14601 NN denotes %
T10633 14599-14600 CD denotes 5
T10632 14585-14598 VBG denotes nondenaturing
T10631 14582-14584 IN denotes on
T10630 14566-14581 NNS denotes electrophoresis
T10629 14563-14565 TO denotes to
T10628 14553-14562 VBN denotes subjected
T10627 14548-14552 VBD denotes were
T10626 14540-14547 NNS denotes Samples
T10625 14538-14539 . denotes .
T10624 14537-14538 -RRB- denotes )
T10623 14532-14537 JJ denotes dI-dC
T10622 14531-14532 -LRB- denotes (
T10621 14527-14531 NN denotes poly
T10620 14524-14526 NN denotes μl
T10619 14523-14524 NN denotes /
T10618 14521-14523 NN denotes ng
T10617 14518-14520 CD denotes 50
T10616 14514-14517 CC denotes and
T10615 14510-14513 NNP denotes P40
T10614 14502-14509 NNP denotes Nonidet
T10613 14500-14501 NN denotes %
T10612 14497-14500 CD denotes 0.2
T10611 14495-14496 , denotes ,
T10610 14492-14495 NNP denotes BSA
T10609 14486-14491 NN denotes mg/ml
T10608 14484-14485 CD denotes 1
T10607 14482-14483 , denotes ,
T10606 14474-14482 NN denotes glycerol
T10605 14472-14473 NN denotes %
T10604 14471-14472 CD denotes 5
T10603 14469-14470 , denotes ,
T10602 14465-14469 NNP denotes EDTA
T10601 14462-14464 NNP denotes mM
T10600 14458-14461 CD denotes 0.5
T10599 14456-14457 , denotes ,
T10598 14442-14456 NN denotes dithiothreitol
T10597 14439-14441 NNP denotes mM
T10596 14437-14438 CD denotes 1
T10595 14435-14436 , denotes ,
T10594 14432-14435 NNP denotes KCl
T10593 14429-14431 NNP denotes mM
T10592 14426-14428 CD denotes 50
T10591 14424-14425 , denotes ,
T10590 14421-14424 CD denotes 7.9
T10589 14418-14420 NNP denotes pH
T10588 14416-14417 , denotes ,
T10587 14408-14416 NNP denotes Tris-HCl
T10586 14405-14407 NNP denotes mM
T10585 14402-14404 CD denotes 20
T10584 14399-14401 IN denotes of
T10583 14388-14398 VBG denotes consisting
T10582 14381-14387 NN denotes buffer
T10581 14373-14380 JJ denotes binding
T10580 14370-14372 IN denotes of
T10579 14367-14369 NN denotes μl
T10578 14364-14366 CD denotes 20
T10577 14361-14363 IN denotes in
T10576 14349-14360 NN denotes temperature
T10575 14344-14348 NN denotes room
T10574 14341-14343 IN denotes at
T10573 14337-14340 NN denotes min
T10572 14334-14336 CD denotes 30
T10571 14330-14333 IN denotes for
T10570 14328-14329 -RRB- denotes )
T10569 14322-14328 NN denotes c.p.m.
T10568 14314-14321 CD denotes 100,000
T10567 14312-14313 : denotes ;
T10566 14310-14312 NN denotes ng
T10565 14307-14309 CD denotes 10
T10564 14306-14307 -LRB- denotes (
T10563 14299-14305 NNS denotes probes
T10562 14295-14298 NNP denotes DNA
T10561 14282-14294 JJ denotes radiolabeled
T10560 14277-14281 IN denotes with
T10559 14267-14276 VBN denotes incubated
T10558 14262-14266 VBD denotes were
T10557 14260-14261 -RRB- denotes )
T10556 14253-14260 NN denotes protein
T10555 14250-14252 IN denotes of
T10481 13912-13916 NN denotes site
T10480 13904-13911 JJ denotes binding
T10479 13898-13903 JJ denotes NF-κB
T10478 13894-13897 DT denotes the
T10477 13881-13893 VBG denotes encompassing
T10476 13874-13880 NNS denotes probes
T10475 13858-13873 NNP denotes Oligonucleotide
T10474 13856-13857 . denotes .
T10473 13852-13856 NNP denotes PBMC
T10472 13848-13851 CD denotes 106
T10471 13846-13847 CD denotes ×
T10470 13844-13845 CD denotes 5
T10469 13838-13843 IN denotes about
T10468 13833-13837 IN denotes from
T10467 13823-13832 VBN denotes extracted
T10466 13818-13822 VBD denotes were
T10465 13809-13817 NNS denotes proteins
T10464 13801-13808 NNP denotes Nuclear
T10463 13796-13800 NN denotes site
T10462 13788-13795 JJ denotes binding
T10461 13782-13787 JJ denotes NF-κB
T10460 13779-13781 IN denotes of
T10459 13773-13778 NN denotes assay
T10458 13758-13772 JJ denotes mobility-shift
T10457 13754-13757 NNP denotes Gel
T10554 14247-14249 NN denotes μg
T10553 14245-14246 CD denotes 2
T10552 14244-14245 -LRB- denotes (
T10551 14235-14243 NNS denotes extracts
T10550 14227-14234 NNP denotes Nuclear
T10549 14225-14226 . denotes .
T10548 14224-14225 -RRB- denotes )
T10547 14221-14224 NNP denotes USA
T10546 14219-14220 , denotes ,
T10545 14217-14219 NNP denotes CA
T10544 14215-14216 , denotes ,
T10543 14210-14215 NNP denotes Jolla
T10542 14207-14209 NNP denotes La
T10541 14205-14206 , denotes ,
T10540 14195-14205 NNP denotes Stratagene
T10539 14194-14195 -LRB- denotes (
T10538 14186-14193 NNS denotes columns
T10537 14173-14185 NN denotes purification
T10536 14167-14172 NN denotes probe
T10535 14159-14166 NNP denotes NucTrap
T10534 14156-14158 IN denotes by
T10533 14148-14155 VBN denotes removed
T10532 14143-14147 VBD denotes were
T10531 14131-14142 NNS denotes nucleotides
T10530 14116-14130 NNP denotes Unincorporated
T10529 14114-14115 . denotes .
T10528 14113-14114 -RRB- denotes )
T10527 14107-14113 NNP denotes TaKaRa
T10526 14106-14107 -LRB- denotes (
T10525 14099-14105 NN denotes kinase
T10524 14084-14098 NN denotes polynucleotide
T10523 14081-14083 CD denotes T4
T10522 14077-14080 CC denotes and
T10521 14075-14076 -RRB- denotes )
T10520 14066-14075 NNP denotes Pharmacia
T10519 14057-14065 NNP denotes Amersham
T10518 14056-14057 -LRB- denotes (
T10517 14051-14055 NNP denotes dATP
T10516 14050-14051 NNP denotes ]
T10515 14045-14050 NNP denotes γ-32P
T10514 14044-14045 NNP denotes [
T10513 14039-14043 IN denotes with
T10512 14032-14038 NN denotes strand
T10511 14026-14031 NN denotes sense
T10510 14022-14025 DT denotes the
T10509 14019-14021 IN denotes of
T10508 14010-14018 VBG denotes labeling
T10507 14006-14009 NN denotes end
T10506 14005-14006 : denotes -
T10505 14004-14005 '' denotes '
T10504 14003-14004 CD denotes 5
T10503 14000-14002 IN denotes by
T10502 13990-13999 VBN denotes generated
T10501 13985-13989 VBD denotes were
T10500 13983-13984 -RRB- denotes )
T10499 13982-13983 '' denotes '
T10498 13977-13982 NN denotes TTC-3
T10497 13973-13976 NNP denotes AAA
T10496 13969-13972 NNP denotes CCA
T10495 13965-13968 NNP denotes TAC
T10494 13961-13964 NNP denotes AAA
T10493 13957-13960 NNP denotes TGG
T10492 13953-13956 NNP denotes ACC
T10491 13949-13952 NNP denotes ATG
T10490 13948-13949 : denotes -
T10489 13947-13948 '' denotes '
T10488 13946-13947 CD denotes 5
T10487 13945-13946 -LRB- denotes (
T10486 13936-13944 NN denotes promoter
T10485 13930-13935 NNP denotes IL-17
T10484 13924-13929 JJ denotes human
T10483 13920-13923 DT denotes the
T10482 13917-13919 IN denotes of
T9907 13684-13685 -LRB- denotes (
T9905 13657-13665 JJ denotes enhanced
T9904 13653-13656 DT denotes the
T9903 13648-13652 IN denotes with
T9902 13639-13647 VBN denotes detected
T9901 13634-13638 VBD denotes were
T9900 13628-13633 NNS denotes bands
T9899 13617-13627 VBN denotes hybridized
T9898 13615-13616 , denotes ,
T9897 13608-13615 VBG denotes washing
T9896 13602-13607 NNP denotes TBS-T
T9895 13596-13601 IN denotes After
T9894 13594-13595 . denotes .
T9893 13583-13594 NN denotes temperature
T9892 13578-13582 NN denotes room
T9891 13575-13577 IN denotes at
T9890 13570-13574 NN denotes hour
T9889 13568-13569 CD denotes 1
T9888 13564-13567 IN denotes for
T9887 13555-13563 VB denotes incubate
T9886 13552-13554 TO denotes to
T9885 13544-13551 VBN denotes allowed
T9884 13540-13543 CC denotes and
T9883 13534-13539 VBN denotes added
T9882 13529-13533 VBD denotes were
T9881 13518-13528 NNS denotes antibodies
T9880 13508-13517 JJ denotes secondary
T9879 13486-13507 JJ denotes peroxidase-conjugated
T9878 13474-13485 JJ denotes horseradish
T9877 13472-13473 , denotes ,
T9876 13467-13472 NNP denotes TBS-T
T9875 13462-13466 IN denotes with
T9874 13456-13461 NNS denotes times
T9873 13451-13455 CD denotes four
T9872 13443-13450 VBG denotes washing
T9871 13437-13442 IN denotes After
T9870 13435-13436 . denotes .
T9869 13434-13435 NNP denotes C
T9868 13433-13434 CD denotes °
T9867 13432-13433 CD denotes 4
T9866 13429-13431 IN denotes at
T9865 13419-13428 JJ denotes overnight
T9864 13409-13418 VBN denotes incubated
T9863 13405-13408 CC denotes and
T9862 13399-13404 VBN denotes added
T9861 13394-13398 VBD denotes were
T9860 13392-13393 , denotes ,
T9859 13383-13392 NN denotes BSA/TBS-T
T9858 13381-13382 NN denotes %
T9857 13380-13381 CD denotes 5
T9856 13377-13379 IN denotes in
T9855 13370-13376 CD denotes 1:1000
T9854 13362-13369 VBN denotes diluted
T9853 13360-13361 , denotes ,
T9852 13359-13360 -RRB- denotes )
T9851 13356-13359 NNP denotes USA
T9850 13354-13355 , denotes ,
T9849 13352-13354 NNP denotes MA
T9848 13350-13351 , denotes ,
T9847 13343-13350 NNP denotes Beverly
T9846 13341-13342 , denotes ,
T9845 13337-13341 NNP denotes Inc.
T9844 13326-13336 NNP denotes Technology
T9843 13316-13325 NNP denotes Signaling
T9842 13311-13315 NNP denotes Cell
T9841 13310-13311 -LRB- denotes (
T9840 13304-13309 NNP denotes IκB-α
T9839 13300-13303 CC denotes and
T9838 13296-13299 NNP denotes Akt
T9837 13281-13295 VBD denotes phosphorylated
T9836 13279-13280 , denotes ,
T9835 13276-13279 NNP denotes Akt
T9834 13268-13275 IN denotes against
T9833 13257-13267 NNS denotes antibodies
T9832 13249-13256 JJ denotes primary
T9831 13244-13248 RB denotes then
T9830 13242-13243 , denotes ,
T9829 13237-13242 NNS denotes hours
T9828 13235-13236 CD denotes 2
T9827 13231-13234 IN denotes for
T9826 13219-13230 NN denotes temperature
T9825 13214-13218 NN denotes room
T9824 13211-13213 IN denotes at
T9823 13209-13210 -RRB- denotes )
T9822 13203-13209 NN denotes saline
T9821 13189-13202 JJ denotes Tris-buffered
T9820 13186-13188 IN denotes in
T9819 13183-13185 CD denotes 20
T9818 13177-13182 CD denotes Tween
T9817 13175-13176 NN denotes %
T9816 13172-13175 CD denotes 0.1
T9815 13171-13172 -LRB- denotes (
T9814 13164-13170 NN denotes buffer
T9813 13158-13163 NNP denotes TBS-T
T9812 13155-13157 IN denotes in
T9811 13150-13154 NN denotes milk
T9810 13142-13149 VBD denotes skimmed
T9809 13140-13141 NN denotes %
T9808 13137-13140 CD denotes 0.1
T9807 13132-13136 IN denotes with
T9806 13119-13131 VBN denotes preincubated
T9805 13115-13118 VBD denotes was
T9804 13106-13114 NN denotes membrane
T9803 13104-13105 , denotes ,
T9802 13091-13104 NN denotes hybridization
T9801 13083-13090 JJ denotes western
T9800 13079-13082 IN denotes For
T9799 13077-13078 . denotes .
T9798 13076-13077 -RRB- denotes )
T9797 13070-13076 NNP denotes Sweden
T9796 13068-13069 , denotes ,
T9795 13061-13068 NNP denotes Uppsala
T9794 13059-13060 , denotes ,
T9793 13052-13059 NNP denotes Biotech
T9792 13042-13051 NNP denotes Pharmacia
T9791 13033-13041 NNP denotes Amersham
T9790 13032-13033 -LRB- denotes (
T9789 13023-13031 NN denotes membrane
T9788 13008-13022 JJ denotes nitrocellulose
T9787 13006-13007 DT denotes a
T9786 13003-13005 TO denotes to
T9785 12991-13002 VBN denotes transferred
T9784 12987-12990 CC denotes and
T9783 12982-12986 NNP denotes PAGE
T9782 12978-12981 NNP denotes SDS
T9781 12976-12977 NN denotes %
T9780 12974-12976 CD denotes 10
T9779 12971-12973 IN denotes by
T9778 12961-12970 VBN denotes separated
T9777 12956-12960 VBD denotes were
T9776 12948-12955 NNS denotes samples
T9775 12940-12947 NN denotes Protein
T9774 12938-12939 . denotes .
T9773 12937-12938 -RRB- denotes )
T9772 12934-12937 NNP denotes USA
T9771 12932-12933 , denotes ,
T9770 12930-12932 NNP denotes CA
T9769 12928-12929 , denotes ,
T9768 12920-12928 NNP denotes Hercules
T9767 12918-12919 , denotes ,
T9766 12911-12918 NNP denotes Bio-Rad
T9765 12910-12911 -LRB- denotes (
T9764 12903-12909 NN denotes method
T9763 12894-12902 NNP denotes Bradford
T9762 12890-12893 DT denotes the
T9761 12885-12889 IN denotes with
T9760 12874-12884 VBN denotes determined
T9759 12869-12873 VBD denotes were
T9758 12856-12868 NNS denotes supernatants
T9757 12852-12855 DT denotes the
T9756 12849-12851 IN denotes in
T9755 12834-12848 NNS denotes concentrations
T9754 12826-12833 NN denotes Protein
T9753 12824-12825 . denotes .
T9752 12821-12824 NN denotes min
T9751 12818-12820 CD denotes 15
T9750 12814-12817 IN denotes for
T9749 12812-12813 -RRB- denotes )
T9748 12811-12812 NN denotes g
T9747 12804-12810 CD denotes 19,000
T9746 12803-12804 -LRB- denotes (
T9745 12796-12802 NN denotes r.p.m.
T9744 12789-12795 CD denotes 14,000
T9743 12786-12788 IN denotes at
T9742 12774-12785 VBD denotes centrifuged
T9741 12770-12773 CC denotes and
T9740 12768-12769 , denotes ,
T9739 12762-12768 NN denotes buffer
T9738 12756-12761 NN denotes lysis
T9737 12752-12755 DT denotes the
T9736 12749-12751 IN denotes in
T9735 12734-12748 NN denotes homogenization
T9734 12731-12733 IN denotes by
T9733 12725-12730 NNS denotes cells
T9732 12721-12724 CD denotes 107
T9731 12715-12720 IN denotes about
T9730 12710-12714 IN denotes from
T9729 12701-12709 VBN denotes prepared
T9728 12696-12700 VBD denotes were
T9727 12688-12695 NNS denotes lysates
T9726 12683-12687 NN denotes cell
T9725 12677-12682 JJ denotes whole
T9724 12675-12676 , denotes ,
T9723 12671-12675 NN denotes hour
T9722 12669-12670 CD denotes 1
T9721 12665-12668 IN denotes for
T9720 12654-12664 NN denotes incubation
T9719 12648-12653 IN denotes After
T9718 12646-12647 . denotes .
T9717 12645-12646 -RRB- denotes )
T9716 12643-12645 NNP denotes μM
T9715 12640-12642 CD denotes 20
T9714 12639-12640 -LRB- denotes (
T9713 12630-12638 NNP denotes LY294002
T9712 12627-12629 IN denotes of
T9711 12619-12626 NN denotes absence
T9710 12616-12618 CC denotes or
T9709 12607-12615 NN denotes presence
T9708 12603-12606 DT denotes the
T9707 12600-12602 IN denotes in
T9706 12598-12599 -RRB- denotes )
T9705 12596-12598 NN denotes ml
T9704 12595-12596 NN denotes /
T9703 12593-12595 NN denotes μg
T9702 12590-12592 CD denotes 10
T9701 12589-12590 -LRB- denotes (
T9700 12580-12588 JJ denotes anti-CD3
T9699 12575-12579 IN denotes with
T9698 12565-12574 VBN denotes incubated
T9697 12560-12564 VBD denotes were
T9696 12555-12559 NNP denotes PBMC
T9695 12549-12554 NNP denotes IκB-α
T9694 12545-12548 CC denotes and
T9693 12541-12544 NNP denotes Akt
T9692 12526-12540 VBD denotes phosphorylated
T9919 13751-13752 . denotes .
T9918 13750-13751 -RRB- denotes )
T9917 13741-13750 NNP denotes Pharmacia
T9916 13732-13740 NNP denotes Amersham
T9915 13731-13732 -LRB- denotes (
T9914 13722-13730 NNS denotes reagents
T9913 13708-13721 JJ denotes Hyperfilm-ECL
T9912 13704-13707 CC denotes and
T9911 13700-13703 NN denotes kit
T9910 13690-13699 NN denotes detection
T9909 13688-13689 -RRB- denotes )
T9908 13685-13688 NNP denotes ECL
T9691 12524-12525 , denotes ,
T9690 12521-12524 NNP denotes Akt
T9689 12518-12520 IN denotes of
T9688 12509-12517 NN denotes analysis
T9687 12504-12508 NN denotes blot
T9686 12496-12503 JJ denotes Western
T9096 12493-12494 . denotes .
T9095 12486-12493 NN denotes product
T9094 12480-12485 NNP denotes GAPDH
T9093 12475-12479 IN denotes over
T9092 12467-12474 NN denotes product
T9091 12463-12466 NNP denotes PCR
T9090 12457-12462 NNP denotes IL-17
T9089 12454-12456 IN denotes of
T9088 12448-12453 NN denotes ratio
T9087 12446-12447 DT denotes a
T9086 12443-12445 IN denotes as
T9085 12433-12442 VBN denotes presented
T9084 12429-12432 VBD denotes was
T9083 12418-12428 NN denotes expression
T9082 12413-12417 NNP denotes mRNA
T9081 12410-12412 IN denotes of
T9080 12404-12409 NN denotes level
T9079 12400-12403 DT denotes The
T9078 12398-12399 . denotes .
T9077 12390-12398 NN denotes molecule
T9076 12385-12389 DT denotes each
T9075 12381-12384 IN denotes for
T9074 12367-12380 NN denotes amplification
T9073 12364-12366 IN denotes of
T9072 12358-12363 NN denotes phase
T9071 12346-12357 JJ denotes exponential
T9070 12342-12345 DT denotes the
T9069 12335-12341 IN denotes within
T9068 12327-12334 VBG denotes falling
T9067 12324-12326 IN denotes as
T9066 12313-12323 VBN denotes determined
T9065 12309-12312 VBD denotes was
T9064 12304-12308 DT denotes this
T9063 12302-12303 : denotes ;
T9062 12297-12302 NNP denotes IL-17
T9061 12293-12296 CC denotes and
T9060 12287-12292 NNP denotes GAPDH
T9059 12282-12286 DT denotes both
T9058 12278-12281 IN denotes for
T9057 12273-12277 DT denotes each
T9056 12266-12272 NNS denotes cycles
T9055 12263-12265 CD denotes 25
T9054 12259-12262 IN denotes for
T9053 12250-12258 VBN denotes repeated
T9052 12245-12249 VBD denotes were
T9051 12238-12244 NNS denotes rounds
T9050 12234-12237 NNP denotes PCR
T9049 12231-12233 NNP denotes C.
T9048 12230-12231 CD denotes °
T9047 12228-12230 CD denotes 72
T9046 12225-12227 IN denotes at
T9045 12214-12224 NN denotes elongation
T9044 12211-12213 IN denotes of
T9043 12207-12210 NN denotes min
T9042 12205-12206 CD denotes 1
T9041 12202-12204 IN denotes by
T9040 12193-12201 VBN denotes followed
T9039 12191-12192 , denotes ,
T9038 12186-12191 NNP denotes IL-17
T9037 12182-12185 CC denotes and
T9036 12176-12181 NNP denotes GAPDH
T9035 12172-12175 IN denotes for
T9034 12170-12171 NNP denotes C
T9033 12169-12170 CD denotes °
T9032 12167-12169 CD denotes 56
T9031 12164-12166 IN denotes at
T9030 12154-12163 VBG denotes annealing
T9029 12151-12153 IN denotes of
T9028 12147-12150 NN denotes min
T9027 12145-12146 CD denotes 1
T9026 12143-12144 , denotes ,
T9025 12142-12143 NNP denotes C
T9024 12141-12142 CD denotes °
T9023 12139-12141 CD denotes 94
T9022 12136-12138 IN denotes at
T9021 12123-12135 NN denotes denaturation
T9020 12120-12122 IN denotes of
T9019 12118-12119 PRP denotes s
T9018 12115-12117 CD denotes 30
T9017 12111-12114 IN denotes for
T9016 12104-12110 NNS denotes cycles
T9015 12096-12103 IN denotes through
T9014 12094-12095 -RRB- denotes )
T9013 12091-12094 NNP denotes USA
T9012 12089-12090 , denotes ,
T9011 12087-12089 NNP denotes CT
T9010 12085-12086 , denotes ,
T9009 12078-12085 NNP denotes Norwalk
T9008 12076-12077 , denotes ,
T9007 12071-12076 NNP denotes Cetus
T9006 12058-12070 NNP denotes Perkin-Elmer
T9005 12057-12058 -LRB- denotes (
T9004 12050-12056 NN denotes cycler
T9003 12042-12049 JJ denotes thermal
T9002 12038-12041 NNP denotes DNA
T9001 12036-12037 DT denotes a
T9000 12033-12035 IN denotes in
T8999 12023-12032 VBN denotes processed
T8998 12018-12022 VBD denotes were
T8997 12008-12017 NNS denotes Reactions
T8996 12006-12007 . denotes .
T8995 12005-12006 '' denotes '
T8994 12001-12005 NN denotes CC-3
T8993 11997-12000 NNP denotes TGA
T8992 11993-11996 NNP denotes GGA
T8991 11989-11992 NNP denotes CAG
T8990 11985-11988 NNP denotes GCT
T8989 11981-11984 NNP denotes TCA
T8988 11977-11980 NNP denotes CGT
T8987 11976-11977 : denotes -
T8986 11975-11976 '' denotes '
T8985 11974-11975 CD denotes 5
T8984 11972-11973 , denotes ,
T8983 11963-11972 NN denotes antisense
T8982 11957-11962 NNP denotes GAPDH
T8981 11955-11956 : denotes ;
T8980 11954-11955 '' denotes '
T8979 11951-11954 NN denotes C-3
T8978 11947-11950 NNP denotes GTA
T8977 11943-11946 NNP denotes TGA
T8976 11939-11942 NNP denotes GCG
T8975 11935-11938 NNP denotes TGG
T8974 11931-11934 NNP denotes TGC
T8973 11927-11930 NNP denotes CGA
T8972 11926-11927 : denotes -
T8971 11925-11926 '' denotes '
T8970 11924-11925 CD denotes 5
T8969 11922-11923 , denotes ,
T8968 11917-11922 NN denotes sense
T8967 11915-11916 -RRB- denotes )
T8966 11910-11915 NNP denotes GAPDH
T8965 11909-11910 -LRB- denotes (
T8964 11895-11908 NN denotes dehydrogenase
T8963 11868-11894 JJ denotes glyceraldehyde-3-phosphate
T8962 11866-11867 : denotes ;
T8961 11865-11866 '' denotes '
T8960 11860-11865 NN denotes CGG-3
T8959 11856-11859 NNP denotes AAT
T8958 11852-11855 NNP denotes GAC
T8957 11848-11851 NNP denotes GTG
T8956 11844-11847 NNP denotes ATG
T8955 11840-11843 NNP denotes CAC
T8954 11836-11839 NNP denotes GGC
T8953 11832-11835 NNP denotes TTA
T8952 11831-11832 : denotes -
T8951 11830-11831 '' denotes '
T8950 11829-11830 CD denotes 5
T8949 11827-11828 , denotes ,
T8948 11818-11827 NN denotes antisense
T8947 11812-11817 NNP denotes IL-17
T8946 11810-11811 : denotes ;
T8945 11809-11810 '' denotes '
T8944 11804-11809 NN denotes TTG-3
T8943 11800-11803 NNP denotes TCA
T8942 11796-11799 NNP denotes ACC
T8941 11792-11795 NNP denotes AAG
T8940 11788-11791 NNP denotes GGG
T8939 11784-11787 NNP denotes CCT
T8938 11780-11783 NNP denotes ACT
T8937 11776-11779 NNP denotes ATG
T8936 11775-11776 : denotes -
T8935 11774-11775 '' denotes '
T8934 11773-11774 CD denotes 5
T8933 11771-11772 , denotes ,
T8932 11766-11771 NN denotes sense
T8931 11760-11765 JJ denotes IL-17
T8930 11758-11759 : denotes :
T8929 11754-11758 VBN denotes used
T8928 11749-11753 VBD denotes were
T8927 11739-11748 NNS denotes molecules
T8926 11734-11738 DT denotes each
T8925 11730-11733 IN denotes for
T8924 11722-11729 NNS denotes primers
T8923 11712-11721 JJ denotes antisense
T8922 11708-11711 CC denotes and
T8921 11702-11707 NN denotes sense
T8920 11692-11701 JJ denotes following
T8919 11688-11691 DT denotes The
T8918 11686-11687 . denotes .
T8917 11684-11686 NN denotes μl
T8916 11681-11683 CD denotes 25
T8915 11678-11680 IN denotes of
T8894 11603-11609 NN denotes buffer
T8893 11599-11602 NNP denotes PCR
T8892 11596-11598 IN denotes in
T8891 11586-11595 VBN denotes performed
T8890 11582-11585 VBD denotes was
T8889 11573-11581 NN denotes reaction
T8888 11569-11572 DT denotes The
T8887 11567-11568 . denotes .
T8886 11560-11567 NNS denotes primers
T8885 11550-11559 JJ denotes antisense
T8884 11546-11549 CC denotes and
T8883 11540-11545 NN denotes sense
T8882 11537-11539 IN denotes of
T8881 11534-11536 NNP denotes μM
T8880 11529-11533 CD denotes 0.25
T8879 11525-11528 CC denotes and
T8878 11523-11524 -RRB- denotes )
T8877 11517-11523 NNP denotes Takara
T8876 11516-11517 -LRB- denotes (
T8875 11505-11515 NN denotes polymerase
T8874 11501-11504 NNP denotes DNA
T8873 11497-11500 NNP denotes Taq
T8872 11494-11496 IN denotes of
T8871 11492-11493 NNP denotes U
T8870 11488-11491 CD denotes 2.5
T8869 11486-11487 , denotes ,
T8868 11481-11486 NNP denotes dNTPs
T8867 11478-11480 NNP denotes mM
T8866 11474-11477 CD denotes 2.5
T8865 11467-11473 VBG denotes adding
T8864 11464-11466 IN denotes by
T8863 11454-11463 VBN denotes performed
T8862 11450-11453 VBD denotes was
T8861 11441-11449 NNS denotes aliquots
T8860 11436-11440 NNP denotes cDNA
T8859 11433-11435 IN denotes of
T8858 11419-11432 NN denotes amplification
T8857 11415-11418 NNP denotes PCR
T8856 11413-11414 . denotes .
T8855 11412-11413 -RRB- denotes )
T8854 11407-11412 NNP denotes Japan
T8853 11405-11406 , denotes ,
T8852 11400-11405 NNP denotes Shiga
T8851 11398-11399 , denotes ,
T8850 11392-11398 NNP denotes Takara
T8849 11391-11392 -LRB- denotes (
T8848 11384-11390 NN denotes system
T8847 11370-11383 NN denotes transcription
T8846 11362-11369 NN denotes reverse
T8845 11360-11361 NN denotes ™
T8844 11349-11360 NNP denotes Superscript
T8843 11345-11348 DT denotes the
T8842 11339-11344 VBG denotes using
T8841 11337-11338 NNP denotes C
T8840 11336-11337 CD denotes °
T8839 11334-11336 CD denotes 42
T8838 11331-11333 IN denotes at
T8837 11321-11330 VBN denotes performed
T8836 11317-11320 VBD denotes was
T8835 11312-11316 NNP denotes mRNA
T8834 11306-11311 JJ denotes total
T8833 11303-11305 IN denotes of
T8832 11300-11302 NN denotes μg
T8831 11298-11299 CD denotes 2
T8830 11295-11297 IN denotes of
T8829 11281-11294 NN denotes transcription
T8828 11273-11280 VB denotes Reverse
T8827 11271-11272 . denotes .
T8826 11259-11271 NNS denotes instructions
T8825 11256-11258 POS denotes 's
T8824 11244-11256 NN denotes manufacturer
T8823 11240-11243 DT denotes the
T8822 11235-11239 IN denotes with
T8821 11224-11234 NN denotes accordance
T8820 11221-11223 IN denotes in
T8819 11219-11220 -RRB- denotes )
T8818 11216-11219 NNP denotes USA
T8817 11214-11215 , denotes ,
T8816 11212-11214 NNP denotes TX
T8815 11210-11211 , denotes ,
T8814 11203-11210 NNP denotes Houston
T8813 11201-11202 , denotes ,
T8812 11189-11201 NNPS denotes Laboratories
T8811 11182-11188 NNP denotes Biotex
T8810 11181-11182 -LRB- denotes (
T8809 11179-11180 NNP denotes B
T8808 11172-11178 NNP denotes RNAzol
T8807 11167-11171 IN denotes with
T8806 11157-11166 VBN denotes extracted
T8805 11153-11156 VBD denotes was
T8804 11148-11152 NNP denotes mRNA
T8803 11146-11147 , denotes ,
T8802 11136-11146 NN denotes incubation
T8801 11133-11135 IN denotes of
T8800 11127-11132 NNS denotes hours
T8799 11124-11126 CD denotes 16
T8798 11118-11123 IN denotes After
T8797 11116-11117 . denotes .
T8796 11115-11116 -RRB- denotes )
T8795 11111-11115 NNP denotes PDTC
T8794 11109-11110 , denotes ,
T8793 11101-11109 CD denotes LY294002
T8792 11100-11101 -LRB- denotes (
T8791 11089-11099 NNS denotes inhibitors
T8790 11086-11088 IN denotes of
T8789 11078-11085 NN denotes absence
T8788 11075-11077 CC denotes or
T8787 11066-11074 NN denotes presence
T8786 11062-11065 DT denotes the
T8785 11059-11061 IN denotes in
T8784 11050-11058 JJ denotes anti-CD3
T8783 11047-11049 IN denotes of
T8782 11032-11046 NNS denotes concentrations
T8781 11024-11031 JJ denotes various
T8780 11019-11023 IN denotes with
T8779 11009-11018 VBN denotes incubated
T8778 11004-11008 VBD denotes were
T8777 10999-11003 NNP denotes PBMC
T8776 10990-10998 NN denotes reaction
T8775 10984-10989 NN denotes chain
T8774 10973-10983 NN denotes polymerase
T8773 10959-10972 NN denotes transcription
T8772 10951-10958 NN denotes reverse
T8771 10934-10950 JJ denotes semiquantitative
T8770 10931-10933 IN denotes by
T8769 10926-10930 NNP denotes mRNA
T8768 10920-10925 NNP denotes IL-17
T8767 10917-10919 IN denotes of
T8766 10902-10916 NN denotes Quantification
T8914 11671-11677 NN denotes volume
T8913 11665-11670 JJ denotes total
T8912 11663-11664 DT denotes a
T8911 11660-11662 IN denotes in
T8910 11658-11659 -RRB- denotes )
T8909 11655-11658 CD denotes 8.3
T8908 11652-11654 NNP denotes pH
T8907 11650-11651 , denotes ,
T8906 11642-11650 NNP denotes Tris-HCl
T8905 11639-11641 NNP denotes mM
T8904 11636-11638 CD denotes 10
T8903 11634-11635 , denotes ,
T8902 11631-11634 NNP denotes KCl
T8901 11628-11630 NNP denotes mM
T8900 11625-11627 CD denotes 50
T8899 11623-11624 , denotes ,
T8898 11618-11623 NNP denotes MgCl2
T8897 11615-11617 NNP denotes mM
T8896 11611-11614 CD denotes 1.5
T8895 11610-11611 -LRB- denotes (
T8117 10899-10900 . denotes .
T8116 10892-10899 NNS denotes samples
T8115 10887-10891 NN denotes test
T8114 10884-10886 IN denotes in
T8113 10878-10883 NNP denotes IL-17
T8112 10875-10877 IN denotes of
T8111 10861-10874 NN denotes determination
T8110 10857-10860 IN denotes for
T8109 10852-10856 VBN denotes used
T8108 10848-10851 CC denotes and
T8107 10846-10847 , denotes ,
T8106 10837-10846 NNS denotes cytokines
T8105 10825-10836 JJ denotes recombinant
T8104 10822-10824 IN denotes of
T8103 10808-10821 NN denotes concentration
T8102 10804-10807 DT denotes the
T8101 10801-10803 IN denotes of
T8100 10797-10800 VB denotes log
T8099 10793-10796 DT denotes the
T8098 10785-10792 IN denotes against
T8097 10777-10784 NN denotes density
T8096 10769-10776 JJ denotes optical
T8095 10760-10768 VBG denotes plotting
T8094 10757-10759 IN denotes by
T8093 10751-10756 VBN denotes drawn
T8092 10747-10750 VBD denotes was
T8091 10741-10746 NN denotes curve
T8090 10732-10740 JJ denotes standard
T8089 10730-10731 DT denotes A
T8088 10728-10729 . denotes .
T8087 10723-10728 NN denotes pg/ml
T8086 10718-10722 CD denotes 2000
T8085 10715-10717 TO denotes to
T8067 10611-10612 . denotes .
T8066 10606-10611 NN denotes pg/ml
T8065 10603-10605 CD denotes 10
T8064 10599-10602 VBD denotes was
T8063 10589-10598 NN denotes detection
T8062 10583-10588 NNP denotes IL-17
T8061 10580-10582 IN denotes of
T8060 10574-10579 NN denotes limit
T8059 10568-10573 JJR denotes lower
T8058 10564-10567 DT denotes The
T8057 10562-10563 . denotes .
T8056 10560-10562 NN denotes nm
T8055 10556-10559 CD denotes 405
T8054 10553-10555 IN denotes at
T8053 10548-10552 VBN denotes read
T8052 10544-10547 VBD denotes was
T8051 10539-10543 NN denotes well
T8050 10534-10538 DT denotes each
T8049 10531-10533 IN denotes of
T8048 10523-10530 NN denotes density
T8047 10515-10522 JJ denotes optical
T8046 10511-10514 DT denotes the
T8045 10507-10510 CC denotes and
T8044 10502-10506 NNP denotes NaOH
T8043 10500-10501 NNP denotes M
T8042 10498-10499 CD denotes 1
T8041 10495-10497 IN denotes of
T8040 10486-10494 NN denotes addition
T8039 10482-10485 DT denotes the
T8038 10479-10481 IN denotes by
T8037 10471-10478 VBN denotes stopped
T8036 10467-10470 VBD denotes was
T8035 10458-10466 NN denotes reaction
T8034 10454-10457 DT denotes The
T8033 10452-10453 . denotes .
T8032 10444-10452 NN denotes reaction
T8031 10438-10443 NN denotes color
T8030 10434-10437 DT denotes the
T8029 10426-10433 VB denotes develop
T8028 10423-10425 TO denotes to
T8014 10342-10346 IN denotes with
T8013 10332-10341 VBN denotes incubated
T8012 10328-10331 CC denotes and
T8011 10322-10327 RB denotes again
T8010 10315-10321 VBD denotes washed
T8009 10310-10314 RB denotes then
T8008 10308-10309 , denotes ,
T8007 10303-10308 NNS denotes hours
T8006 10301-10302 CD denotes 2
T8005 10297-10300 IN denotes for
T8004 10287-10296 VBN denotes incubated
T8003 10283-10286 VBD denotes was
T8002 10281-10282 -RRB- denotes )
T8001 10276-10281 NNP denotes Sigma
T8000 10275-10276 -LRB- denotes (
T7999 10265-10274 NN denotes conjugate
T7998 10254-10264 JJ denotes peroxidase
T7997 10242-10253 JJ denotes horseradish
T7996 10232-10241 NN denotes phosphate
T7995 10223-10231 JJ denotes alkaline
T7994 10210-10222 NNP denotes streptavidin
T7993 10208-10209 , denotes ,
T7992 10201-10208 VBG denotes washing
T7991 10195-10200 IN denotes After
T7990 10193-10194 . denotes .
T7989 10182-10193 NN denotes temperature
T7988 10177-10181 NN denotes room
T7987 10174-10176 IN denotes at
T7986 10168-10173 NNS denotes hours
T7985 10166-10167 CD denotes 2
T7984 10162-10165 IN denotes for
T7983 10160-10161 -RRB- denotes )
T7982 10153-10160 NNPS denotes Systems
T7981 10151-10152 NNP denotes D
T7980 10149-10150 CC denotes &
T7979 10147-10148 NNP denotes R
T7978 10146-10147 -LRB- denotes (
T7977 10140-10145 NNP denotes IL-17
T7976 10132-10139 IN denotes against
T7975 10121-10131 NNS denotes antibodies
T7974 10110-10120 NN denotes monoclonal
T7973 10104-10109 NN denotes mouse
T7972 10091-10103 VBN denotes biotinylated
T7971 10085-10090 JJ denotes ng/ml
T7970 10081-10084 CD denotes 500
T7969 10076-10080 IN denotes with
T7968 10066-10075 VBN denotes incubated
T7967 10061-10065 RB denotes then
T7966 10057-10060 CC denotes and
T7965 10055-10056 , denotes ,
T7964 10053-10055 CD denotes 20
T7963 10040-10052 NNP denotes saline/Tween
T7962 10021-10039 JJ denotes phosphate-buffered
T7961 10016-10020 IN denotes with
T7960 10010-10015 NNS denotes times
T7959 10005-10009 CD denotes four
T7958 9998-10004 VBN denotes washed
T7957 9993-9997 VBD denotes were
T7956 9986-9992 NNS denotes Plates
T7955 9984-9985 . denotes .
T7954 9979-9984 NNS denotes hours
T7953 9977-9978 CD denotes 2
T7952 9973-9976 IN denotes for
T7951 9961-9972 NN denotes temperature
T7950 9956-9960 NN denotes room
T7949 9953-9955 IN denotes at
T7948 9943-9952 VBD denotes incubated
T7947 9939-9942 CC denotes and
T7946 9933-9938 NN denotes plate
T7945 9925-9932 JJ denotes 96-well
T7944 9921-9924 DT denotes the
T7943 9918-9920 TO denotes to
T7942 9912-9917 VBN denotes added
T7941 9907-9911 VBD denotes were
T7940 9905-9906 -RRB- denotes )
T7939 9898-9905 NNPS denotes Systems
T7938 9896-9897 NNP denotes D
T7937 9894-9895 CC denotes &
T7936 9892-9893 NNP denotes R
T7935 9891-9892 -LRB- denotes (
T7934 9885-9890 NNP denotes IL-17
T7933 9873-9884 JJ denotes recombinant
T7932 9864-9872 JJ denotes standard
T7931 9860-9863 DT denotes the
T7930 9856-9859 CC denotes and
T7929 9848-9855 NNS denotes samples
T7928 9843-9847 NN denotes test
T7927 9841-9842 , denotes ,
T7926 9840-9841 -RRB- denotes )
T7925 9839-9840 NNP denotes C
T7924 9838-9839 NN denotes °
T7923 9836-9838 CD denotes 25
T7922 9833-9835 CD denotes 22
T7921 9832-9833 -LRB- denotes (
T7920 9820-9831 NN denotes temperature
T7919 9815-9819 NN denotes room
T7918 9812-9814 IN denotes at
T7917 9806-9811 NNS denotes hours
T7916 9804-9805 CD denotes 2
T7915 9800-9803 IN denotes for
T7914 9797-9799 CD denotes 20
T7913 9791-9796 CD denotes Tween
T7912 9789-9790 NN denotes %
T7911 9785-9789 CD denotes 0.05
T7910 9784-9785 VBP denotes /
T7909 9783-9784 -RRB- denotes )
T7908 9780-9783 NNP denotes BSA
T7907 9779-9780 -LRB- denotes (
T7906 9771-9778 NN denotes albumin
T7905 9765-9770 NN denotes serum
T7904 9758-9764 JJ denotes bovine
T7903 9756-9757 NN denotes %
T7902 9748-9756 CD denotes saline/1
T7901 9729-9747 JJ denotes phosphate-buffered
T7900 9724-9728 IN denotes with
T7899 9715-9723 VBG denotes blocking
T7898 9709-9714 IN denotes After
T7897 9707-9708 . denotes .
T7896 9698-9707 JJ denotes overnight
T7895 9696-9697 NNP denotes C
T7894 9695-9696 CD denotes °
T7893 9694-9695 CD denotes 4
T7892 9691-9693 IN denotes at
T7891 9689-9690 -RRB- denotes )
T7890 9682-9689 NNPS denotes Systems
T7889 9680-9681 NNP denotes D
T7888 9678-9679 CC denotes &
T7887 9676-9677 NNP denotes R
T7886 9675-9676 -LRB- denotes (
T7885 9669-9674 NNP denotes IL-17
T7884 9661-9668 IN denotes against
T7883 9650-9660 NNS denotes antibodies
T7882 9639-9649 JJ denotes monoclonal
T7881 9636-9638 NN denotes ml
T7880 9635-9636 NN denotes /
T7879 9633-9635 NN denotes μg
T7878 9631-9632 CD denotes 4
T7877 9626-9630 IN denotes with
T7876 9619-9625 VBN denotes coated
T7875 9615-9618 VBD denotes was
T7874 9613-9614 -RRB- denotes )
T7873 9609-9613 NNP denotes Nunc
T7872 9608-9609 -LRB- denotes (
T7871 9602-9607 NN denotes plate
T7870 9594-9601 JJ denotes 96-well
T7869 9592-9593 DT denotes a
T7868 9590-9591 , denotes ,
T7867 9585-9590 NN denotes brief
T7866 9582-9584 IN denotes In
T7865 9580-9581 . denotes .
T7864 9579-9580 NNP denotes ]
T7863 9577-9579 CD denotes 20
T7862 9576-9577 NNP denotes [
T7861 9565-9575 RB denotes previously
T7860 9555-9564 VBN denotes described
T7859 9552-9554 IN denotes as
T7858 9546-9551 NN denotes assay
T7857 9532-9545 JJ denotes immunosorbent
T7856 9518-9531 JJ denotes enzyme-linked
T7855 9509-9517 NN denotes sandwich
T7854 9506-9508 IN denotes by
T7853 9497-9505 VBN denotes measured
T7852 9493-9496 VBD denotes was
T8084 10712-10714 CD denotes 10
T8083 10707-10711 IN denotes from
T8082 10699-10706 VBG denotes ranging
T8081 10697-10698 , denotes ,
T8080 10689-10697 NN denotes standard
T8079 10677-10688 NN denotes calibration
T8078 10675-10676 DT denotes a
T8077 10672-10674 IN denotes as
T8076 10667-10671 VBN denotes used
T8075 10663-10666 VBD denotes was
T8074 10656-10662 NN denotes medium
T8073 10648-10655 NN denotes culture
T8072 10645-10647 IN denotes in
T8071 10637-10644 VBN denotes diluted
T8070 10631-10636 NN denotes IL-17
T8069 10625-10630 JJ denotes human
T8068 10613-10624 JJ denotes Recombinant
T7185 9417-9418 . denotes .
T7184 9411-9417 NN denotes marker
T7183 9406-9410 NN denotes cell
T7182 9404-9405 NNP denotes T
T7181 9400-9403 NNP denotes CD4
T7180 9396-9399 DT denotes the
T7179 9392-9395 VBD denotes had
T7178 9386-9391 NNS denotes cells
T7177 9377-9385 JJ denotes isolated
T7176 9373-9376 DT denotes the
T7175 9370-9372 IN denotes of
T7174 9368-9369 -RRB- denotes )
T7173 9367-9368 NN denotes %
T7172 9365-9367 CD denotes 97
T7171 9360-9364 IN denotes than
T7170 9355-9359 JJR denotes more
T7169 9354-9355 -LRB- denotes (
T7168 9349-9353 JJS denotes Most
T7167 9347-9348 . denotes .
T7166 9341-9347 NN denotes sorter
T7165 9333-9340 NNP denotes Vantage
T7164 9328-9332 NNP denotes FACS
T7163 9326-9327 DT denotes a
T7162 9323-9325 IN denotes on
T7161 9317-9322 NNS denotes cells
T7160 9309-9316 JJ denotes stained
T7159 9306-9308 IN denotes of
T7158 9297-9305 NN denotes analysis
T7157 9286-9296 JJ denotes cytometric
T7156 9281-9285 NN denotes flow
T7155 9278-9280 IN denotes by
T7154 9269-9277 VBN denotes assessed
T7153 9265-9268 VBD denotes was
T7152 9259-9264 NNS denotes cells
T7151 9256-9258 IN denotes of
T7150 9249-9255 NN denotes purity
T7149 9245-9248 DT denotes The
T7148 9243-9244 . denotes .
T7147 9238-9243 IN denotes above
T7146 9228-9237 VBN denotes described
T7145 9225-9227 IN denotes as
T7144 9215-9224 VBD denotes separated
T7143 9202-9214 RB denotes magnetically
T7142 9198-9201 CC denotes and
T7141 9196-9197 , denotes ,
T7140 9195-9196 -RRB- denotes )
T7851 9480-9492 NNS denotes supernatants
T7850 9472-9479 NN denotes culture
T7849 9469-9471 IN denotes in
T7848 9463-9468 NNP denotes IL-17
T7847 9457-9462 NNP denotes IL-17
T7846 9454-9456 IN denotes of
T7845 9448-9453 NN denotes assay
T7844 9434-9447 JJ denotes immunosorbent
T7843 9420-9433 JJ denotes Enzyme-linked
T7139 9194-9195 NNP denotes C
T7138 9193-9194 NN denotes °
T7137 9191-9193 CD denotes 12
T7136 9189-9190 CD denotes 6
T7135 9187-9188 , denotes ,
T7134 9184-9187 NN denotes min
T7133 9181-9183 CD denotes 15
T7132 9179-9180 : denotes ;
T7131 9169-9179 NN denotes suspension
T7130 9164-9168 NN denotes cell
T7129 9161-9163 IN denotes of
T7128 9158-9160 NN denotes μl
T7127 9155-9157 CD denotes 80
T7126 9152-9154 TO denotes to
T7125 9146-9151 VBD denotes added
T7124 9143-9145 NN denotes μl
T7123 9140-9142 CD denotes 20
T7122 9139-9140 -LRB- denotes (
T7121 9128-9138 NNS denotes microbeads
T7120 9109-9127 JJ denotes anti-phycoerythrin
T7119 9104-9108 IN denotes with
T7118 9096-9103 VBN denotes labeled
T7117 9083-9095 RB denotes magnetically
T7116 9081-9082 , denotes ,
T7115 9075-9081 VBN denotes washed
T7114 9070-9074 VBD denotes were
T7113 9056-9069 NN denotes phycoerythrin
T7112 9047-9055 JJ denotes anti-CD4
T7111 9042-9046 IN denotes with
T7110 9034-9041 VBD denotes stained
T7109 9028-9033 NNS denotes cells
T7108 9026-9027 , denotes ,
T7107 9013-9026 RB denotes Alternatively
T7106 9011-9012 . denotes .
T7105 9005-9011 NN denotes magnet
T7104 9001-9004 DT denotes the
T7103 8996-9000 IN denotes from
T7102 8988-8995 NN denotes removal
T7101 8982-8987 IN denotes after
T7100 8975-8981 NN denotes column
T7099 8971-8974 DT denotes the
T7098 8966-8970 IN denotes from
T7097 8957-8965 NNS denotes aliquots
T7096 8954-8956 NN denotes ml
T7095 8950-8953 CD denotes 0.5
T7094 8946-8949 CD denotes two
T7093 8943-8945 IN denotes in
T7092 8933-8942 VBN denotes collected
T7091 8928-8932 VBD denotes were
T7090 8922-8927 NNS denotes cells
T7089 8913-8921 JJ denotes Enriched
T7088 8911-8912 . denotes .
T7087 8903-8911 NN denotes fraction
T7086 8894-8902 JJ denotes negative
T7085 8890-8893 DT denotes the
T7084 8887-8889 IN denotes as
T7083 8877-8886 VBN denotes collected
T7082 8872-8876 VBD denotes were
T7081 8865-8871 NNS denotes washes
T7080 8862-8864 NN denotes ml
T7079 8860-8861 CD denotes 1
T7078 8856-8859 CD denotes two
T7077 8852-8855 CC denotes and
T7076 8839-8851 JJ denotes Flow-through
T7075 8837-8838 . denotes .
T7074 8831-8837 NN denotes column
T7073 8828-8830 NNP denotes MS
T7072 8823-8827 NNP denotes MACS
T7071 8821-8822 DT denotes a
T7070 8816-8820 IN denotes with
T7069 8809-8815 VBN denotes fitted
T7068 8802-8808 NN denotes magnet
T7067 8793-8801 NNP denotes AutoMACS
T7066 8790-8792 DT denotes an
T7065 8787-8789 IN denotes on
T7064 8779-8786 RB denotes usually
T7063 8777-8778 , denotes ,
T7062 8768-8777 VBD denotes separated
T7061 8755-8767 RB denotes magnetically
T7060 8751-8754 CC denotes and
T7059 8748-8750 NN denotes μl
T7058 8744-8747 CD denotes 500
T7057 8741-8743 IN denotes in
T7056 8729-8740 VBN denotes resuspended
T7055 8727-8728 , denotes ,
T7054 8719-8727 VBN denotes pelleted
T7053 8717-8718 , denotes ,
T7052 8711-8717 NN denotes buffer
T7051 8702-8710 VBG denotes staining
T7050 8698-8701 NNP denotes FBS
T7049 8695-8697 IN denotes of
T7048 8692-8694 NN denotes ml
T7047 8688-8691 CD denotes 2.5
T7046 8685-8687 IN denotes in
T7045 8677-8684 VBN denotes diluted
T7044 8672-8676 VBD denotes were
T7043 8666-8671 NNS denotes Cells
T7042 8664-8665 . denotes .
T7041 8661-8664 NN denotes min
T7040 8658-8660 CD denotes 10
T7039 8650-8657 JJ denotes further
T7038 8648-8649 DT denotes a
T7037 8644-8647 IN denotes for
T7036 8638-8643 VBN denotes added
T7035 8633-8637 VBD denotes were
T7034 8622-8632 NNS denotes antibodies
T7033 8598-8621 JJ denotes fluorochrome-conjugated
T7032 8595-8597 IN denotes of
T7031 8587-8594 NNS denotes amounts
T7030 8576-8586 NNP denotes Saturating
T7029 8573-8575 NNP denotes C.
T7028 8572-8573 NN denotes °
T7027 8570-8572 CD denotes 12
T7026 8568-8569 CD denotes 6
T7025 8565-8567 IN denotes at
T7024 8561-8564 NN denotes min
T7023 8558-8560 CD denotes 15
T7022 8554-8557 IN denotes for
T7021 8544-8553 VBN denotes incubated
T7020 8540-8543 CC denotes and
T7019 8534-8539 VBN denotes added
T7018 8529-8533 VBD denotes were
T7017 8527-8528 -RRB- denotes )
T7016 8525-8527 NN denotes μl
T7015 8522-8524 CD denotes 20
T7014 8521-8522 -LRB- denotes (
T7013 8510-8520 NNS denotes microbeads
T7012 8501-8509 JJ denotes Anti-CD4
T7011 8499-8500 . denotes .
T7010 8493-8499 NN denotes buffer
T7009 8484-8492 VBG denotes staining
T7008 8480-8483 NNP denotes FBS
T7007 8477-8479 IN denotes of
T7006 8474-8476 NN denotes μl
T7005 8471-8473 CD denotes 80
T7004 8468-8470 IN denotes in
T7003 8456-8467 VBN denotes resuspended
T7002 8451-8455 VBD denotes were
T7001 8446-8450 NNP denotes PBMC
T7000 8444-8445 . denotes .
T6999 8443-8444 NNP denotes ]
T6998 8441-8443 CD denotes 19
T6997 8440-8441 NNP denotes [
T6996 8438-8439 -RRB- denotes )
T6995 8430-8438 NNP denotes Miltenyi
T6994 8429-8430 -LRB- denotes (
T6993 8416-8428 NN denotes manufacturer
T6992 8412-8415 DT denotes the
T6991 8409-8411 IN denotes by
T6990 8397-8408 VBN denotes recommended
T6989 8394-8396 IN denotes as
T6988 8382-8393 RB denotes essentially
T6987 8377-8381 VBN denotes used
T6986 8372-8376 VBD denotes were
T6985 8361-8371 NNS denotes microbeads
T6984 8352-8360 JJ denotes Anti-CD4
T6983 8347-8351 NNP denotes MACS
T6982 8344-8346 IN denotes by
T6981 8334-8343 NN denotes isolation
T6980 8327-8333 NNP denotes T-cell
T6979 8325-8326 CD denotes +
T6978 8322-8325 CD denotes CD4
T6490 8319-8320 . denotes .
T6489 8316-8319 NNP denotes SEM
T6488 8314-8315 VBP denotes ±
T6487 8308-8313 NNS denotes means
T6486 8305-8307 IN denotes as
T6485 8295-8304 VBN denotes expressed
T6484 8291-8294 VBP denotes are
T6483 8283-8290 NNS denotes results
T6482 8279-8282 CC denotes and
T6481 8277-8278 , denotes ,
T6480 8267-8277 NN denotes triplicate
T6479 8264-8266 IN denotes in
T6478 8261-8263 RP denotes up
T6477 8257-8260 VBN denotes set
T6476 8252-8256 VBD denotes were
T6475 8243-8251 NNS denotes cultures
T6474 8239-8242 DT denotes All
T6473 8237-8238 . denotes .
T6472 8230-8237 VBN denotes assayed
T6471 8224-8229 IN denotes until
T6470 8222-8223 NNP denotes C
T6469 8221-8222 CD denotes °
T6468 8218-8221 CD denotes -20
T6467 8215-8217 IN denotes at
T6466 8208-8214 VBN denotes stored
T6465 8204-8207 CC denotes and
T6464 8194-8203 VBN denotes collected
T6463 8189-8193 VBD denotes were
T6462 8183-8188 NNS denotes media
T6461 8173-8182 JJ denotes cell-free
T6460 8171-8172 , denotes ,
T6459 8170-8171 -RRB- denotes )
T6458 8164-8170 VBN denotes stated
T6457 8154-8163 RB denotes otherwise
T6456 8147-8153 IN denotes unless
T6455 8146-8147 -LRB- denotes (
T6454 8140-8145 NNS denotes hours
T6453 8137-8139 CD denotes 24
T6452 8133-8136 IN denotes for
T6451 8122-8132 NN denotes incubation
T6450 8116-8121 IN denotes After
T6449 8114-8115 . denotes .
T6448 8104-8114 NN denotes wortmannin
T6447 8101-8103 CC denotes or
T6446 8087-8100 NN denotes dexamethasone
T6445 8085-8086 , denotes ,
T6444 8078-8085 NNP denotes PD98059
T6443 8076-8077 , denotes ,
T6442 8068-8076 NNP denotes SB203580
T6441 8066-8067 , denotes ,
T6440 8058-8066 NNP denotes LY294002
T6439 8056-8057 , denotes ,
T6434 8031-8040 NN denotes rapamycin
T6433 8029-8030 , denotes ,
T6432 8024-8029 NNP denotes FK506
T6431 8018-8023 VBN denotes added
T6430 8014-8017 VBD denotes was
T6429 8009-8013 NN denotes well
T6428 8004-8008 DT denotes each
T6427 8001-8003 TO denotes To
T6426 7999-8000 . denotes .
T6425 7994-7999 NNS denotes hours
T6424 7991-7993 CD denotes 24
T6423 7987-7990 IN denotes for
T6422 7977-7986 VBN denotes incubated
T6421 7972-7976 VBD denotes were
T6420 7966-7971 NNS denotes cells
T6419 7962-7965 CC denotes and
T6418 7955-7961 NN denotes medium
T6417 7951-7954 DT denotes the
T6416 7948-7950 TO denotes to
T6415 7942-7947 VBN denotes added
T6414 7937-7941 VBD denotes were
T6413 7935-7936 -RRB- denotes )
T6412 7930-7935 NN denotes ng/ml
T6411 7926-7929 CD denotes 500
T6410 7923-7925 CD denotes 10
T6409 7922-7923 -LRB- denotes (
T6408 7920-7921 DT denotes A
T6407 7908-7919 NN denotes cyclosporin
T6406 7905-7907 IN denotes of
T6405 7890-7904 NNS denotes concentrations
T6404 7882-7889 JJ denotes various
T6403 7880-7881 , denotes ,
T6402 7868-7880 RB denotes Subsequently
T6401 7866-7867 . denotes .
T6400 7863-7866 CD denotes CO2
T6399 7861-7862 NN denotes %
T6398 7860-7861 CD denotes 5
T6397 7857-7859 IN denotes in
T6396 7855-7856 NNP denotes C
T6395 7854-7855 CD denotes °
T6394 7852-7854 CD denotes 37
T6393 7849-7851 IN denotes at
T6392 7843-7848 NNS denotes hours
T6391 7840-7842 CD denotes 24
T6390 7836-7839 IN denotes for
T6389 7826-7835 VBD denotes incubated
T6388 7822-7825 CC denotes and
T6387 7820-7821 , denotes ,
T6386 7819-7820 -RRB- denotes )
T6385 7812-7819 NNP denotes Denmark
T6384 7810-7811 , denotes ,
T6383 7802-7810 NNP denotes Roskilde
T6382 7800-7801 , denotes ,
T6381 7796-7800 NNP denotes Nunc
T6380 7795-7796 -LRB- denotes (
T6379 7788-7794 NNS denotes plates
T6378 7777-7787 JJ denotes multi-well
T6377 7769-7776 JJ denotes 24-well
T6376 7764-7768 IN denotes into
T6375 7754-7763 VBN denotes dispensed
T6339 7572-7574 TO denotes to
T6338 7563-7571 VBN denotes adjusted
T6337 7558-7562 VBD denotes were
T6336 7546-7557 NNS denotes suspensions
T6335 7541-7545 NN denotes cell
T6334 7537-7540 DT denotes the
T6333 7535-7536 , denotes ,
T6332 7530-7535 NN denotes brief
T6331 7527-7529 IN denotes In
T6330 7525-7526 . denotes .
T6329 7524-7525 NNP denotes ]
T6328 7522-7524 CD denotes 18
T6327 7521-7522 NNP denotes [
T6326 7510-7520 RB denotes previously
T6325 7500-7509 VBN denotes described
T6324 7497-7499 IN denotes as
T6323 7487-7496 VBN denotes performed
T6322 7482-7486 VBD denotes were
T6321 7473-7481 NNS denotes cultures
T6320 7468-7472 NNP denotes Cell
T6319 7466-7467 . denotes .
T6318 7452-7466 NN denotes centrifugation
T6317 7435-7451 JJ denotes density-gradient
T6316 7433-7434 -RRB- denotes )
T6315 7427-7433 NNP denotes SG1077
T6314 7426-7427 -LRB- denotes (
T6438 8052-8056 NNP denotes PDTC
T6437 8050-8051 , denotes ,
T6436 8042-8050 NN denotes curcumin
T6435 8040-8041 , denotes ,
T5830 7288-7289 . denotes .
T5829 7287-7288 -RRB- denotes )
T5828 7280-7287 NNP denotes Germany
T5827 7278-7279 , denotes ,
T5826 7268-7278 NNP denotes Schwalbach
T5825 7267-7268 -LRB- denotes (
T5823 7251-7255 IN denotes from
T5822 7242-7250 VBN denotes obtained
T5821 7237-7241 VBD denotes were
T5820 7229-7236 CD denotes PD98059
T5819 7225-7228 CC denotes and
T5818 7214-7224 NN denotes wortmannin
T5817 7212-7213 , denotes ,
T5816 7207-7212 NNP denotes FK506
T5815 7205-7206 , denotes ,
T5814 7197-7205 NNP denotes SB203580
T5813 7195-7196 , denotes ,
T5812 7187-7195 CD denotes LY294002
T5811 7185-7186 . denotes .
T5810 7184-7185 -RRB- denotes )
T5809 7181-7184 NNP denotes USA
T5808 7179-7180 , denotes ,
T5807 7177-7179 NNP denotes CA
T5806 7175-7176 , denotes ,
T5805 7170-7175 NNP denotes Diego
T5804 7166-7169 NNP denotes San
T5803 7165-7166 -LRB- denotes (
T5802 7153-7164 NNP denotes Biosciences
T5801 7150-7152 NNP denotes BD
T5800 7145-7149 IN denotes from
T5799 7136-7144 VBN denotes obtained
T5798 7131-7135 VBD denotes were
T5797 7122-7130 NN denotes antibody
T5796 7111-7121 JJ denotes monoclonal
T5795 7101-7110 JJ denotes anti-CD28
T5794 7097-7100 CC denotes and
T5793 7088-7096 NN denotes antibody
T5792 7077-7087 JJ denotes monoclonal
T5791 7068-7076 JJ denotes Anti-CD3
T5790 7066-7067 . denotes .
T5789 7065-7066 -RRB- denotes )
T5788 7062-7065 NNP denotes USA
T5787 7060-7061 , denotes ,
T5786 7058-7060 NNP denotes MA
T5785 7056-7057 , denotes ,
T5784 7051-7056 NNP denotes Louis
T5783 7048-7050 NNP denotes St
T5782 7047-7048 -LRB- denotes (
T5781 7043-7046 NNP denotes Co.
T5780 7034-7042 NNP denotes Chemical
T5779 7028-7033 NNP denotes Sigma
T5778 7024-7027 DT denotes the
T5777 7019-7023 IN denotes from
T5776 7010-7018 VBN denotes obtained
T5775 7006-7009 DT denotes all
T5774 7001-7005 VBD denotes were
T5773 6992-7000 NN denotes curcumin
T5772 6988-6991 CC denotes and
T5771 6974-6987 NN denotes dexamethasone
T5770 6972-6973 , denotes ,
T5769 6963-6972 NN denotes rapamycin
T5768 6961-6962 , denotes ,
T5767 6960-6961 -RRB- denotes )
T5766 6956-6960 NNP denotes PDTC
T5765 6955-6956 -LRB- denotes (
T5764 6939-6954 NN denotes dithiocarbamate
T5763 6927-6938 JJ denotes pyrrolidine
T5762 6925-6926 , denotes ,
T5761 6924-6925 -RRB- denotes )
T5760 6921-6924 NNP denotes PHA
T5759 6920-6921 -LRB- denotes (
T5758 6901-6919 NNP denotes Phytohemagglutinin
T5757 6899-6900 . denotes .
T5756 6898-6899 -RRB- denotes )
T5755 6887-6898 NNP denotes Switzerland
T5754 6885-6886 , denotes ,
T5753 6880-6885 NNP denotes Basel
T5752 6879-6880 -LRB- denotes (
T5751 6874-6878 NNP denotes Ltd.
T5750 6867-6873 NNP denotes Sandos
T5749 6864-6866 IN denotes by
T5748 6855-6863 VBN denotes provided
T5747 6851-6854 VBD denotes was
T5746 6849-6850 NNP denotes A
T5745 6837-6848 NNP denotes Cyclosporin
T5744 6835-6836 . denotes .
T5743 6834-6835 -RRB- denotes )
T5742 6831-6834 NNP denotes USA
T5741 6829-6830 , denotes ,
T5740 6827-6829 NNP denotes MA
T5739 6825-6826 , denotes ,
T5738 6816-6825 NNP denotes Cambridge
T5737 6815-6816 -LRB- denotes (
T5736 6810-6814 NNP denotes Inc.
T5735 6802-6809 NNP denotes Endogen
T5734 6797-6801 IN denotes from
T5733 6787-6796 VBN denotes purchased
T5732 6782-6786 VBD denotes were
T5731 6777-6781 NN denotes IL-1
T5730 6773-6776 CC denotes and
T5719 6716-6725 VBN denotes purchased
T5718 6712-6715 VBD denotes was
T5717 6710-6711 NN denotes β
T5716 6709-6710 : denotes -
T5715 6708-6709 -RRB- denotes )
T5714 6705-6708 NNP denotes TGF
T5713 6704-6705 -LRB- denotes (
T5712 6697-6703 NN denotes factor
T5711 6690-6696 NN denotes growth
T5710 6677-6689 VBG denotes transforming
T5709 6665-6676 JJ denotes Recombinant
T5708 6663-6664 . denotes .
T5707 6662-6663 -RRB- denotes )
T5706 6659-6662 NNP denotes USA
T5705 6657-6658 , denotes ,
T5704 6655-6657 NNP denotes MN
T5703 6653-6654 , denotes ,
T5702 6642-6653 NNP denotes Minneapolis
T5701 6641-6642 -LRB- denotes (
T5700 6633-6640 NNS denotes systems
T5699 6631-6632 NNP denotes D
T5698 6629-6630 CC denotes &
T5697 6627-6628 NN denotes R
T5696 6622-6626 IN denotes from
T5695 6612-6621 VBN denotes purchased
T5694 6607-6611 VBD denotes were
T5693 6602-6606 NNP denotes IL-8
T5692 6598-6601 CC denotes and
T5691 6593-6597 NNP denotes IL-6
T5690 6591-6592 , denotes ,
T5689 6585-6591 NNP denotes MIP-1β
T5688 6583-6584 , denotes ,
T5687 6582-6583 NN denotes α
T5686 6580-6582 CD denotes -1
T5685 6579-6580 -RRB- denotes )
T5684 6576-6579 NNP denotes MIP
T5683 6575-6576 -LRB- denotes (
T5682 6567-6574 NN denotes protein
T5681 6554-6566 JJ denotes inflammatory
T5680 6543-6553 NN denotes macrophage
T5679 6541-6542 , denotes ,
T5678 6540-6541 -RRB- denotes )
T5677 6535-6540 NN denotes MCP-1
T5676 6534-6535 -LRB- denotes (
T5675 6524-6533 NN denotes protein-1
T5674 6508-6523 NN denotes chemoattractant
T5673 6499-6507 NN denotes monocyte
T5672 6497-6498 , denotes ,
T5671 6492-6497 NNP denotes IL-15
T5670 6490-6491 , denotes ,
T5669 6485-6490 NNP denotes IL-18
T5668 6483-6484 , denotes ,
T5667 6478-6483 NNP denotes IL-17
T5666 6466-6477 NNP denotes Recombinant
T5665 6457-6465 NNP denotes Reagents
T5729 6767-6772 NN denotes TNF-α
T5728 6755-6766 JJ denotes Recombinant
T5727 6753-6754 . denotes .
T5726 6752-6753 -RRB- denotes )
T5725 6750-6752 NNP denotes UK
T5724 6748-6749 , denotes ,
T5723 6742-6748 NNP denotes London
T5722 6741-6742 -LRB- denotes (
T5721 6731-6740 NNP denotes Peprotech
T5720 6726-6730 IN denotes from
T5202 6454-6455 . denotes .
T5201 6445-6454 NNP denotes Committee
T5200 6438-6444 NNP denotes Ethics
T5199 6429-6437 NNP denotes Research
T5198 6423-6428 NNP denotes Human
T5197 6417-6422 NNP denotes Korea
T5196 6414-6416 IN denotes of
T5195 6403-6413 NNP denotes University
T5194 6394-6402 NNP denotes Catholic
T5193 6390-6393 DT denotes the
T5192 6387-6389 IN denotes by
T5191 6378-6386 VBN denotes approved
T5190 6374-6377 VBD denotes was
T5189 6365-6373 NN denotes protocol
T5188 6361-6364 DT denotes the
T5187 6357-6360 CC denotes and
T5186 6355-6356 , denotes ,
T5185 6347-6355 VBN denotes obtained
T5184 6343-6346 VBD denotes was
T5183 6335-6342 NN denotes consent
T5182 6326-6334 VBN denotes Informed
T5181 6324-6325 . denotes .
T5180 6323-6324 -RRB- denotes )
T5179 6318-6323 NNS denotes years
T5178 6315-6317 CD denotes 57
T5177 6312-6314 CD denotes 24
T5176 6306-6311 NN denotes range
T5175 6305-6306 -LRB- denotes (
T5174 6299-6304 NNS denotes years
T5173 6297-6298 CD denotes 6
T5172 6295-6296 NN denotes ±
T5171 6292-6294 CD denotes 30
T5170 6288-6291 CC denotes and
T5169 6286-6287 -RRB- denotes )
T5168 6281-6286 NNS denotes years
T5167 6278-6280 CD denotes 68
T5166 6275-6277 CD denotes 34
T5165 6269-6274 NN denotes range
T5164 6268-6269 -LRB- denotes (
T5163 6262-6267 NNS denotes years
T5162 6260-6261 CD denotes 8
T5161 6258-6259 NN denotes ±
T5160 6255-6257 CD denotes 50
T5159 6250-6254 VBD denotes were
T5158 6241-6249 NNS denotes controls
T5157 6233-6240 JJ denotes healthy
T5156 6229-6232 DT denotes the
T5155 6225-6228 CC denotes and
T5154 6222-6224 NNP denotes OA
T5153 6217-6221 IN denotes with
T5152 6208-6216 NNS denotes patients
T5151 6204-6207 DT denotes the
T5150 6201-6203 IN denotes of
T5149 6196-6200 NNS denotes ages
T5148 6191-6195 JJ denotes mean
T5147 6187-6190 DT denotes The
T5146 6185-6186 . denotes .
T5145 6177-6185 NNS denotes diseases
T5144 6167-6176 JJ denotes rheumatic
T5143 6164-6166 DT denotes no
T5142 6160-6163 VBD denotes had
T5141 6156-6159 WP denotes who
T5140 6154-6155 -RRB- denotes )
T5139 6149-6154 NNS denotes women
T5138 6146-6148 CD denotes 11
T5137 6142-6145 CC denotes and
T5136 6138-6141 NNS denotes men
T5135 6136-6137 CD denotes 3
T5134 6135-6136 -LRB- denotes (
T5133 6126-6134 NNS denotes controls
T5132 6118-6125 JJ denotes healthy
T5131 6115-6117 CD denotes 14
T5130 6110-6114 IN denotes with
T5129 6106-6109 CC denotes and
T5128 6104-6105 -RRB- denotes )
T5127 6099-6104 NNS denotes women
T5126 6096-6098 CD denotes 11
T5125 6092-6095 CC denotes and
T5123 6086-6087 CD denotes 3
T5122 6085-6086 -LRB- denotes (
T5121 6082-6084 NNP denotes OA
T5120 6077-6081 IN denotes with
T5119 6068-6076 NNS denotes patients
T5118 6065-6067 CD denotes 14
T5117 6060-6064 IN denotes with
T5116 6055-6059 VBN denotes made
T5115 6050-6054 VBD denotes were
T5114 6038-6049 NNS denotes Comparisons
T5113 6036-6037 . denotes .
T5112 6031-6036 NN denotes study
T5111 6027-6030 DT denotes the
T5110 6024-6026 TO denotes to
T5109 6018-6023 NN denotes entry
T5108 6011-6017 IN denotes before
T5107 6005-6010 NNS denotes hours
T5106 6002-6004 CD denotes 48
T5105 5994-6001 VBN denotes stopped
T5104 5989-5993 VBD denotes were
T5103 5977-5988 NNS denotes medications
T5102 5973-5976 DT denotes All
T5101 5971-5972 . denotes .
T5100 5970-5971 -RRB- denotes )
T5099 5965-5970 NNS denotes years
T5098 5962-5964 CD denotes 71
T5097 5959-5961 CD denotes 23
T5096 5953-5958 NN denotes range
T5095 5952-5953 -LRB- denotes (
T5094 5946-5951 NNS denotes years
T5093 5944-5945 -RRB- denotes )
T5092 5941-5944 NNP denotes SEM
T5091 5939-5940 NN denotes ±
T5090 5934-5938 JJ denotes mean
T5089 5933-5934 -LRB- denotes (
T5088 5931-5932 CD denotes 8
T5087 5929-5930 NN denotes ±
T5086 5926-5928 CD denotes 50
T5085 5922-5925 VBD denotes was
T5084 5919-5921 NNP denotes RA
T5083 5914-5918 IN denotes with
T5082 5905-5913 NNS denotes patients
T5081 5901-5904 DT denotes the
T5080 5898-5900 IN denotes of
T5079 5894-5897 NN denotes age
T5078 5890-5893 DT denotes The
T5077 5888-5889 . denotes .
T5076 5887-5888 NNP denotes ]
T5075 5885-5887 CD denotes 17
T5074 5884-5885 NNP denotes [
T5073 5882-5883 -RRB- denotes )
T5072 5871-5882 NNP denotes Association
T5071 5860-5870 NNP denotes Rheumatism
T5070 5851-5859 JJ denotes American
T5069 5847-5850 DT denotes the
T5068 5838-5846 RB denotes formerly
T5067 5837-5838 -LRB- denotes (
T5066 5824-5836 NNP denotes Rheumatology
T5065 5821-5823 IN denotes of
T5064 5813-5820 NNP denotes College
T5063 5804-5812 JJ denotes American
T5062 5800-5803 DT denotes the
T5061 5797-5799 IN denotes of
T5060 5788-5796 NNS denotes criteria
T5059 5780-5787 VBN denotes revised
T5058 5775-5779 CD denotes 1987
T5057 5771-5774 DT denotes the
T5056 5761-5770 VBD denotes fulfilled
T5055 5757-5760 WP denotes who
T5054 5754-5756 NNP denotes RA
T5053 5749-5753 IN denotes with
T5052 5747-5748 -RRB- denotes )
T5051 5742-5747 NNS denotes women
T5050 5739-5741 CD denotes 19
T5049 5735-5738 CC denotes and
T5048 5731-5734 NNS denotes men
T5047 5729-5730 CD denotes 5
T5046 5728-5729 -LRB- denotes (
T4443 5646-5647 . denotes .
T4442 5644-5646 NNP denotes RA
T4441 5641-5643 IN denotes in
T4440 5630-5640 NNS denotes strategies
T4439 5618-5629 JJ denotes therapeutic
T4438 5614-5617 JJ denotes new
T4437 5610-5613 IN denotes for
T4436 5599-5609 NNS denotes directions
T4435 5592-5598 JJ denotes future
T4434 5588-5591 CC denotes and
T4433 5585-5587 NNP denotes RA
T4432 5582-5584 IN denotes of
T4431 5569-5581 NN denotes pathogenesis
T4430 5565-5568 DT denotes the
T4429 5560-5564 IN denotes into
T4428 5551-5559 NNS denotes insights
T4427 5547-5550 JJ denotes new
T4426 5539-5546 VB denotes provide
T4425 5533-5538 MD denotes might
T4424 5525-5532 NNS denotes results
T4423 5519-5524 DT denotes These
T4422 5517-5518 . denotes .
T4421 5515-5517 NNP denotes RA
T4420 5512-5514 IN denotes in
T4419 5506-5511 NNP denotes IL-17
T4418 5497-5505 NN denotes cytokine
T4417 5484-5496 JJ denotes inflammatory
T4416 5480-5483 JJ denotes key
T4415 5476-5479 DT denotes the
T4414 5473-5475 IN denotes of
T4413 5458-5472 NN denotes overproduction
T4412 5454-5457 DT denotes the
T4411 5451-5453 IN denotes in
T4410 5442-5450 VBN denotes involved
T4409 5439-5441 VB denotes be
T4408 5433-5438 MD denotes might
T4407 5427-5432 NNP denotes NF-κB
T4406 5423-5426 CC denotes and
T4405 5419-5422 NNP denotes Akt
T4404 5418-5419 VBP denotes /
T4403 5417-5418 -RRB- denotes )
T4402 5413-5417 NNP denotes PI3K
T4401 5412-5413 -LRB- denotes (
T4400 5403-5411 JJ denotes 3-kinase
T4399 5386-5402 NN denotes phosphoinositide
T4398 5376-5385 VBG denotes involving
T4397 5368-5375 NN denotes pathway
T4396 5358-5367 VBG denotes signaling
T4395 5344-5357 JJ denotes intracellular
T4394 5340-5343 DT denotes the
T4393 5335-5339 IN denotes that
T4392 5329-5334 VBD denotes found
T4391 5326-5328 PRP denotes We
T4390 5324-5325 . denotes .
T4389 5317-5324 NN denotes pathway
T4388 5304-5316 NN denotes transduction
T4387 5294-5303 VBG denotes signaling
T4386 5290-5293 PRP$ denotes its
T4385 5286-5289 CC denotes and
T4384 5283-5285 NNP denotes RA
T4383 5278-5282 IN denotes with
T4382 5269-5277 NNS denotes patients
T4381 5266-5268 IN denotes of
T4380 5261-5265 NNP denotes PBMC
T4379 5258-5260 IN denotes in
T4378 5247-5257 NN denotes production
T4377 5241-5246 JJ denotes IL-17
T4376 5229-5240 VB denotes investigate
T4375 5226-5228 TO denotes to
T4374 5218-5225 NNS denotes stimuli
T4373 5210-5217 JJ denotes various
T4372 5205-5209 VBD denotes used
T4371 5202-5204 PRP denotes we
T4370 5196-5201 NN denotes study
T4369 5188-5195 JJ denotes present
T4368 5184-5187 DT denotes the
T4367 5181-5183 IN denotes In
T4366 5179-5180 . denotes .
T4365 5170-5179 JJ denotes uncertain
T4364 5162-5169 VBZ denotes remains
T4363 5151-5161 NN denotes production
T4362 5145-5150 JJ denotes IL-17
T4361 5141-5144 IN denotes for
T4360 5133-5140 NN denotes pathway
T4359 5120-5132 NN denotes transduction
T4358 5113-5119 NN denotes signal
T4357 5099-5112 JJ denotes intracellular
T4356 5095-5098 DT denotes the
T4355 5093-5094 , denotes ,
T4354 5092-5093 NNP denotes ]
T4353 5084-5092 CD denotes 12,15,16
T4352 5083-5084 NNP denotes [
T4351 5075-5082 NNS denotes studies
T4350 5067-5074 JJR denotes earlier
T4349 5064-5066 IN denotes in
T4348 5053-5063 VBN denotes documented
T4347 5048-5052 VBN denotes been
T4346 5044-5047 VBZ denotes has
T4345 5041-5043 NNP denotes RA
T4344 5038-5040 IN denotes in
T4343 5025-5037 NN denotes inflammation
T4342 5019-5024 JJ denotes joint
T4341 5016-5018 IN denotes in
T4340 5010-5015 NNP denotes IL-17
T4339 5007-5009 IN denotes of
T4338 4994-5006 NN denotes contribution
T4337 4990-4993 DT denotes the
T4336 4981-4989 IN denotes Although
T4335 4979-4980 . denotes .
T4334 4978-4979 NNP denotes ]
T4333 4976-4978 CD denotes 14
T4332 4975-4976 NNP denotes [
T4331 4969-4974 NNS denotes cells
T4330 4967-4968 NNP denotes T
T4329 4965-4966 CD denotes +
T4328 4962-4965 CD denotes CD8
T4327 4958-4961 CC denotes and
T4326 4956-4957 NN denotes +
T4325 4953-4956 CD denotes CD4
T4324 4948-4952 DT denotes both
T4323 4943-4947 IN denotes from
T4322 4932-4942 NN denotes production
T4321 4926-4931 JJ denotes IL-17
T4320 4923-4925 IN denotes of
T4319 4915-4922 NN denotes trigger
T4318 4905-4914 JJ denotes efficient
T4317 4902-4904 DT denotes an
T4316 4899-4901 VB denotes be
T4315 4893-4898 MD denotes could
T4314 4887-4892 NN denotes IL-23
T4313 4882-4886 IN denotes that
T4312 4875-4881 VBD denotes showed
T4311 4870-4874 RB denotes also
T4310 4859-4869 NNS denotes colleagues
T4309 4855-4858 CC denotes and
T4308 4848-4854 NNP denotes Happel
T4307 4846-4847 , denotes ,
T4306 4838-4846 RB denotes Recently
T4305 4836-4837 . denotes .
T4304 4835-4836 NNP denotes ]
T4303 4833-4835 CD denotes 13
T4302 4832-4833 NNP denotes [
T4301 4823-4831 NNS denotes pathways
T4300 4813-4822 JJ denotes sensitive
T4299 4805-4812 JJ denotes steroid
T4298 4801-4804 CC denotes and
T3974 3099-3102 DT denotes the
T3973 3086-3098 VBG denotes infiltrating
T3972 3075-3085 NN denotes population
T3971 3070-3074 NN denotes cell
T3970 3062-3069 JJS denotes largest
T3969 3058-3061 DT denotes the
T3968 3054-3057 VBP denotes are
T3967 3049-3053 PRP denotes they
T3966 3041-3048 IN denotes because
T3965 3030-3040 JJ denotes undisputed
T3964 3026-3029 VBD denotes was
T3963 3023-3025 NNP denotes RA
T3962 3020-3022 IN denotes as
T3961 3015-3019 JJ denotes such
T3960 3007-3014 NN denotes disease
T3959 2996-3006 JJ denotes autoimmune
T3958 2993-2995 IN denotes of
T3957 2980-2992 NN denotes pathogenesis
T3956 2976-2979 DT denotes the
T3955 2973-2975 IN denotes in
T3954 2967-2972 NNS denotes cells
T3953 2965-2966 NNP denotes T
T3952 2962-2964 IN denotes of
T3951 2954-2961 NN denotes primacy
T3950 2950-2953 DT denotes the
T3949 2948-2949 , denotes ,
T3948 2945-2948 RB denotes ago
T3947 2938-2944 NN denotes decade
T3946 2936-2937 DT denotes a
T3945 2931-2935 IN denotes over
T3944 2924-2930 JJ denotes little
T3943 2922-2923 DT denotes A
T3942 2920-2921 . denotes .
T3941 2919-2920 NN denotes ]
T3940 2918-2919 CD denotes 2
T3939 2917-2918 JJ denotes [
T3938 2904-2916 NNS denotes applications
T3937 2892-2903 JJ denotes therapeutic
T3936 2888-2891 JJ denotes new
T3935 2885-2887 IN denotes of
T3934 2873-2884 NN denotes development
T3933 2869-2872 DT denotes the
T3932 2866-2868 IN denotes in
T3931 2860-2865 NN denotes issue
T3930 2850-2859 JJ denotes important
T3929 2846-2849 DT denotes the
T3928 2841-2845 VBN denotes been
T3927 2837-2840 VBZ denotes has
T3926 2827-2836 NNS denotes cytokines
T5045 5719-5727 NNS denotes patients
T5044 5716-5718 CD denotes 24
T5043 5711-5715 IN denotes from
T5042 5702-5710 VBN denotes obtained
T5041 5698-5701 VBD denotes was
T5040 5690-5697 NN denotes consent
T5039 5681-5689 VBN denotes Informed
T5038 5672-5680 NNS denotes Patients
T3925 2814-2826 JJ denotes inflammatory
T3924 2810-2813 JJ denotes key
T3923 2807-2809 IN denotes of
T3922 2798-2806 NN denotes blockade
T3921 2794-2797 DT denotes the
T3920 2789-2793 IN denotes that
T3919 2781-2788 VBP denotes suggest
T3918 2778-2780 CD denotes -1
T3917 2777-2778 -RRB- denotes )
T3916 2775-2777 NNP denotes IL
T3915 2774-2775 -LRB- denotes (
T3914 2762-2773 NN denotes interleukin
T3913 2758-2761 CC denotes and
T3912 2756-2757 -RRB- denotes )
T3911 2755-2756 VBN denotes α
T3910 2754-2755 : denotes -
T3909 2753-2754 -RRB- denotes )
T3908 2750-2753 NNP denotes TNF
T3907 2749-2750 -LRB- denotes (
T3906 2742-2748 NN denotes factor
T3905 2733-2741 NN denotes necrosis
T3904 2727-2732 NN denotes tumor
T3903 2724-2726 IN denotes of
T3902 2713-2723 NNS denotes inhibitors
T3901 2708-2712 IN denotes with
T3900 2699-2707 VBN denotes obtained
T3899 2690-2698 NNS denotes benefits
T3898 2681-2689 JJ denotes clinical
T3897 2671-2680 JJ denotes favorable
T3896 2667-2670 DT denotes The
T3895 2665-2666 . denotes .
T3894 2664-2665 NNP denotes ]
T3893 2663-2664 CD denotes 1
T3892 2662-2663 NNP denotes [
T3891 2659-2661 NNP denotes RA
T3890 2656-2658 IN denotes in
T3889 2649-2655 NNS denotes joints
T3888 2646-2648 IN denotes of
T3887 2634-2645 NN denotes destruction
T3886 2630-2633 DT denotes the
T3885 2627-2629 IN denotes in
T3884 2617-2626 JJ denotes important
T3883 2614-2616 VB denotes be
T3882 2611-2613 TO denotes to
T3881 2605-2610 VBN denotes known
T3880 2601-2604 VBP denotes are
T3879 2595-2600 NNS denotes cells
T3878 2589-2594 DT denotes these
T3877 2584-2588 IN denotes from
T3876 2575-2583 VBN denotes released
T3875 2565-2574 NNS denotes cytokines
T3874 2549-2564 JJ denotes Proinflammatory
T3873 2547-2548 . denotes .
T3872 2536-2547 NN denotes hyperplasia
T3871 2527-2535 JJ denotes synovial
T3870 2523-2526 CC denotes and
T3869 2521-2522 , denotes ,
T3868 2516-2521 JJ denotes joint
T3867 2512-2515 DT denotes the
T3866 2507-2511 IN denotes into
T3865 2501-2506 NNS denotes cells
T3864 2499-2500 NNP denotes T
T3863 2495-2498 CC denotes and
T3862 2483-2494 NNS denotes macrophages
T3861 2480-2482 IN denotes of
T3860 2466-2479 NNS denotes infiltrations
T3859 2463-2465 IN denotes by
T3858 2449-2462 VBN denotes characterized
T3857 2446-2448 VBZ denotes is
T3856 2444-2445 -RRB- denotes )
T3855 2442-2444 NNP denotes RA
T3854 2441-2442 -LRB- denotes (
T3853 2431-2440 NNS denotes arthritis
T3852 2420-2430 JJ denotes Rheumatoid
T4164 4095-4104 NN denotes induction
T4163 4091-4094 DT denotes the
T4162 4088-4090 IN denotes by
T4161 4077-4087 NN denotes resorption
T4160 4072-4076 NN denotes bone
T4159 4059-4071 JJ denotes osteoclastic
T4158 4050-4058 VB denotes activate
T4157 4045-4049 RB denotes also
T4156 4041-4044 MD denotes can
T4155 4035-4040 NNP denotes IL-17
T4154 4030-4034 IN denotes that
T4153 4017-4029 VBD denotes demonstrated
T4152 4004-4016 NNS denotes observations
T4151 3997-4003 JJ denotes Recent
T4150 3995-3996 . denotes .
T4149 3994-3995 NNP denotes ]
T4148 3993-3994 CD denotes 6
T4147 3992-3993 NNP denotes [
T4146 3986-3991 NNS denotes cells
T4145 3984-3985 NNP denotes T
T4144 3981-3983 IN denotes by
T4143 3972-3980 VBN denotes produced
T4142 3969-3971 VBZ denotes is
T4141 3966-3968 PRP denotes it
T4140 3964-3965 , denotes ,
T4139 3958-3964 JJ denotes second
T4138 3956-3957 : denotes ;
T4137 3946-3956 NNS denotes properties
T4136 3930-3945 JJ denotes proinflammatory
T4135 3926-3929 VBZ denotes has
T4134 3920-3925 NNP denotes IL-17
T4133 3918-3919 , denotes ,
T4132 3914-3918 NNP denotes IL-1
T4131 3910-3913 CC denotes and
T4130 3904-3909 NNP denotes TNF-α
T4129 3901-3903 TO denotes to
T4128 3891-3900 RB denotes similarly
T4127 3889-3890 , denotes ,
T4126 3884-3889 RB denotes first
T4125 3882-3883 : denotes :
T4124 3875-3882 NNS denotes reasons
T4123 3869-3874 JJ denotes major
T4122 3865-3868 CD denotes two
T4121 3861-3864 IN denotes for
T4120 3852-3860 NN denotes interest
T4119 3849-3851 IN denotes of
T4118 3846-3848 VBZ denotes is
T4117 3837-3845 NN denotes cytokine
T4116 3832-3836 DT denotes This
T4115 3830-3831 . denotes .
T4114 3829-3830 NNP denotes ]
T4113 3828-3829 CD denotes 5
T4112 3827-3828 VBP denotes [
T4111 3815-3826 NNS denotes fibroblasts
T4110 3812-3814 IN denotes by
T4109 3807-3811 NNP denotes IL-8
T4108 3803-3806 CC denotes and
T4107 3798-3802 NNP denotes IL-6
T4106 3791-3797 VB denotes induce
T4105 3787-3790 MD denotes can
T4104 3781-3786 WDT denotes which
T4103 3779-3780 , denotes ,
T4102 3774-3779 NNS denotes cells
T4101 3772-3773 NNP denotes T
T4100 3762-3771 VBN denotes activated
T4099 3759-3761 IN denotes by
T4098 3752-3758 RB denotes mainly
T4097 3743-3751 VBD denotes secreted
T4096 3733-3742 NNS denotes cytokines
T4095 3720-3732 JJ denotes inflammatory
T4094 3716-3719 DT denotes the
T4093 3713-3715 IN denotes of
T4092 3709-3712 CD denotes one
T4091 3706-3708 VBZ denotes is
T4090 3700-3705 NNP denotes IL-17
T4089 3698-3699 . denotes .
T4088 3691-3698 NNS denotes aspects
T4087 3681-3690 JJ denotes different
T4086 3678-3680 IN denotes in
T4085 3667-3677 VBN denotes elucidated
T4084 3664-3666 VB denotes be
T4083 3661-3663 TO denotes to
T4082 3655-3660 VBZ denotes needs
T4081 3649-3654 NNS denotes cells
T4080 3647-3648 NNP denotes T
T4079 3644-3646 IN denotes of
T4078 3639-3643 NN denotes role
T4077 3635-3638 DT denotes the
T4076 3633-3634 , denotes ,
T4075 3632-3633 NNP denotes ]
T4074 3631-3632 CD denotes 4
T4073 3630-3631 NNP denotes [
T4072 3627-3629 NNP denotes RA
T4071 3624-3626 IN denotes in
T4070 3614-3623 NNS denotes cytokines
T4069 3612-3613 -RRB- denotes )
T4068 3609-3612 NN denotes Th1
T4067 3608-3609 -LRB- denotes (
T4066 3606-3607 CD denotes 1
T4065 3601-3605 NN denotes type
T4064 3594-3600 NN denotes helper
T4063 3592-3593 NNP denotes T
T4062 3589-3591 IN denotes of
T4061 3581-3588 NN denotes skewing
T4060 3577-3580 DT denotes the
T4059 3573-3576 CC denotes and
T4058 3571-3572 , denotes ,
T4057 3563-3571 NN denotes collagen
T4056 3560-3562 NNP denotes II
T4055 3555-3559 NN denotes type
T4054 3552-3554 TO denotes to
T4053 3541-3551 RB denotes especially
T4052 3539-3540 , denotes ,
T4051 3534-3539 NNS denotes cells
T4050 3532-3533 NNP denotes T
T4049 3523-3531 JJ denotes specific
T4048 3515-3522 NN denotes antigen
T4047 3512-3514 IN denotes of
T4046 3498-3511 NN denotes proliferation
T4045 3489-3497 JJ denotes enhanced
T4044 3485-3488 DT denotes the
T4043 3472-3484 VBN denotes demonstrated
T4042 3464-3471 RB denotes already
T4041 3459-3463 VBP denotes have
T4040 3456-3458 PRP denotes we
T4039 3448-3455 IN denotes Because
T4038 3446-3447 . denotes .
T4037 3445-3446 NNP denotes ]
T4036 3444-3445 CD denotes 3
T4035 3443-3444 NNP denotes [
T4034 3440-3442 NNP denotes RA
T4033 3437-3439 IN denotes of
T4032 3424-3436 NN denotes pathogenesis
T4031 3420-3423 DT denotes the
T4030 3417-3419 IN denotes in
T4029 3411-3416 NNS denotes cells
T4028 3409-3410 NNP denotes T
T4027 3406-3408 IN denotes of
T4026 3401-3405 NN denotes role
T4025 3397-3400 DT denotes the
T4024 3386-3396 VBN denotes questioned
T4023 3382-3385 VBZ denotes has
T4022 3374-3381 NN denotes paradox
T4021 3369-3373 DT denotes This
T4020 3367-3368 . denotes .
T4019 3359-3367 NN denotes synovium
T4018 3348-3358 JJ denotes rheumatoid
T4017 3345-3347 IN denotes in
T4016 3336-3344 JJ denotes abundant
T4015 3331-3335 VBD denotes were
T4014 3325-3330 NNP denotes TNF-α
T4013 3321-3324 CC denotes and
T4012 3315-3320 NNP denotes IL-18
T4011 3313-3314 , denotes ,
T4010 3308-3313 NNP denotes IL-15
T4009 3306-3307 , denotes ,
T4008 3302-3306 NNP denotes IL-6
T4007 3300-3301 , denotes ,
T4006 3296-3300 NNP denotes IL-1
T4005 3286-3295 VBG denotes including
T4004 3276-3285 NNS denotes cytokines
T4003 3265-3275 NN denotes fibroblast
T4002 3261-3264 CC denotes and
T4001 3250-3260 NN denotes macrophage
T4000 3242-3249 IN denotes whereas
T3999 3240-3241 , denotes ,
T3998 3238-3240 NNP denotes RA
T3997 3235-3237 IN denotes of
T3996 3228-3234 NNS denotes joints
T3995 3224-3227 DT denotes the
T3994 3221-3223 IN denotes in
T3993 3208-3220 NN denotes interferon-γ
T3992 3204-3207 CC denotes and
T3991 3199-3203 NN denotes IL-2
T3990 3196-3198 IN denotes as
T3989 3191-3195 JJ denotes such
T3988 3181-3190 NNS denotes cytokines
T3987 3168-3180 JJ denotes cell-derived
T3986 3166-3167 NNP denotes T
T3985 3163-3165 IN denotes of
T3984 3155-3162 NN denotes paucity
T3983 3142-3154 VBD denotes demonstrated
T3982 3134-3141 NNS denotes studies
T3981 3131-3133 IN denotes of
T3980 3124-3130 NN denotes series
T3979 3122-3123 DT denotes a
T3978 3120-3121 , denotes ,
T3977 3113-3120 RB denotes However
T3976 3111-3112 . denotes .
T3975 3103-3111 NN denotes synovium
T4297 4788-4800 NN denotes cyclosporine
T4296 4785-4787 IN denotes by
T4295 4783-4784 -RRB- denotes )
T4294 4779-4783 NNP denotes PBMC
T4293 4778-4779 -LRB- denotes (
T4292 4772-4777 NNS denotes cells
T4291 4760-4771 NN denotes mononuclear
T4290 4754-4759 NN denotes blood
T4289 4743-4753 JJ denotes peripheral
T4288 4740-4742 NNP denotes RA
T4287 4737-4739 IN denotes in
T4286 4726-4736 NN denotes production
T4285 4720-4725 JJ denotes IL-17
T4284 4717-4719 IN denotes of
T4283 4709-4716 NN denotes trigger
T4282 4699-4708 JJ denotes important
T4281 4696-4698 DT denotes an
T4280 4693-4695 VB denotes be
T4279 4690-4692 TO denotes to
T4278 4681-4689 VBN denotes reported
T4277 4676-4680 VBN denotes been
T4276 4672-4675 VBZ denotes has
T4275 4670-4671 , denotes ,
T4274 4659-4670 NNS denotes macrophages
T4273 4649-4658 VBN denotes activated
T4272 4644-4648 IN denotes from
T4271 4635-4643 VBN denotes secreted
T4270 4633-4634 , denotes ,
T4269 4628-4633 CD denotes IL-15
T4268 4626-4627 . denotes .
T4267 4625-4626 NNP denotes ]
T4266 4620-4625 CD denotes 11,12
T4265 4619-4620 NNP denotes [
T4264 4610-4618 NN denotes synovium
T4263 4606-4609 DT denotes the
T4262 4603-4605 IN denotes in
T4261 4597-4602 NNS denotes cells
T4260 4595-4596 NNP denotes T
T4259 4593-4594 NNP denotes +
T4258 4590-4593 NNP denotes CD4
T4257 4587-4589 IN denotes by
T4256 4578-4586 VBN denotes produced
T4255 4574-4577 VBD denotes was
T4254 4571-4573 PRP denotes it
T4253 4567-4570 CC denotes and
T4252 4565-4566 , denotes ,
T4251 4564-4565 -RRB- denotes )
T4250 4562-4564 NNP denotes OA
T4249 4561-4562 -LRB- denotes (
T4248 4546-4560 NNS denotes osteoarthritis
T4247 4541-4545 IN denotes with
T4246 4532-4540 NNS denotes patients
T4245 4529-4531 IN denotes in
T4244 4524-4528 IN denotes than
T4243 4521-4523 NNP denotes RA
T4242 4516-4520 IN denotes with
T4241 4507-4515 NNS denotes patients
T4240 4504-4506 IN denotes in
T4239 4497-4503 JJR denotes higher
T4238 4483-4496 RB denotes significantly
T4237 4478-4482 VBD denotes were
T4236 4471-4477 NNS denotes fluids
T4235 4462-4470 JJ denotes synovial
T4234 4459-4461 IN denotes in
T4233 4453-4458 NNP denotes IL-17
T4232 4450-4452 IN denotes of
T4231 4443-4449 NNS denotes Levels
T4230 4441-4442 . denotes .
T4229 4440-4441 NNP denotes ]
T4228 4436-4440 CD denotes 8-10
T4227 4435-4436 NNP denotes [
T4226 4429-4434 NNS denotes cells
T4225 4419-4428 JJ denotes dendritic
T4224 4415-4418 DT denotes the
T4223 4406-4414 VB denotes activate
T4222 4402-4405 CC denotes and
T4221 4388-4401 VB denotes differentiate
T4220 4385-4387 TO denotes to
T4219 4377-4384 NN denotes ability
T4218 4373-4376 DT denotes the
T4217 4369-4372 VBZ denotes has
T4216 4365-4368 CC denotes and
T4215 4363-4364 , denotes ,
T4214 4351-4363 NNS denotes chondrocytes
T4213 4348-4350 IN denotes by
T4212 4342-4347 NN denotes oxide
T4211 4335-4341 JJ denotes nitric
T4210 4331-4334 CC denotes and
T4209 4328-4330 CD denotes E2
T4208 4314-4327 NN denotes prostaglandin
T4207 4311-4313 IN denotes of
T4206 4307-4310 CC denotes and
T4205 4305-4306 , denotes ,
T4204 4293-4305 NNS denotes synoviocytes
T4203 4290-4292 IN denotes by
T4202 4283-4289 NN denotes factor
T4201 4272-4282 JJ denotes inhibitory
T4200 4263-4271 NN denotes leukemia
T4199 4259-4262 CC denotes and
T4198 4254-4258 NN denotes IL-6
T4197 4251-4253 IN denotes of
T4196 4240-4250 NN denotes production
T4195 4236-4239 DT denotes the
T4194 4225-4235 VBZ denotes stimulates
T4193 4220-4224 RB denotes also
T4192 4217-4219 PRP denotes It
T4191 4215-4216 . denotes .
T4190 4214-4215 NNP denotes ]
T4189 4213-4214 CD denotes 7
T4188 4212-4213 NNP denotes [
T4187 4209-4211 NNP denotes RA
T4186 4206-4208 IN denotes in
T4185 4198-4205 NN denotes erosion
T4184 4193-4197 NN denotes bony
T4183 4190-4192 IN denotes in
T4182 4181-4189 VBN denotes involved
T4181 4178-4180 VBZ denotes is
T4180 4172-4177 WDT denotes which
T4179 4170-4171 , denotes ,
T4178 4169-4170 -RRB- denotes )
T4177 4163-4169 NN denotes ligand
T4176 4161-4162 NNP denotes ]
T4175 4156-4161 NNP denotes NF-κB
T4174 4155-4156 NNP denotes [
T4173 4152-4154 NNP denotes κB
T4172 4145-4151 NN denotes factor
T4171 4137-4144 JJ denotes nuclear
T4170 4134-4136 IN denotes of
T4169 4124-4133 NN denotes activator
T4168 4115-4123 NN denotes receptor
T4167 4114-4115 -LRB- denotes (
T4166 4108-4113 NNP denotes RANKL
T4165 4105-4107 IN denotes of
T1823 2404-2405 . denotes .
T1822 2402-2404 NNP denotes RA
T1821 2399-2401 IN denotes in
T1820 2393-2398 NNP denotes IL-17
T1819 2384-2392 NN denotes cytokine
T1818 2371-2383 JJ denotes inflammatory
T1817 2367-2370 JJ denotes key
T1816 2363-2366 DT denotes the
T1815 2360-2362 IN denotes of
T1814 2345-2359 NN denotes overproduction
T1813 2341-2344 DT denotes the
T1812 2338-2340 IN denotes in
T1811 2329-2337 VBN denotes involved
T1810 2325-2328 VBP denotes are
T1809 2319-2324 NNP denotes NF-κB
T1808 2315-2318 CC denotes and
T1807 2306-2314 NNP denotes PI3K/Akt
T1806 2303-2305 IN denotes on
T1805 2293-2302 JJ denotes dependent
T1804 2284-2292 NNS denotes pathways
T1803 2271-2283 NN denotes transduction
T1802 2264-2270 NN denotes signal
T1801 2259-2263 IN denotes that
T1800 2251-2258 VBP denotes suggest
T1799 2243-2250 NNS denotes results
T1798 2237-2242 DT denotes These
T1797 2235-2236 . denotes .
T1796 2225-2235 NN denotes production
T1795 2219-2224 JJ denotes IL-17
T1794 2212-2218 VB denotes affect
T1793 2208-2211 RB denotes not
T1792 2204-2207 VBD denotes did
T1791 2200-2203 CD denotes 1/2
T1790 2193-2199 NN denotes kinase
T1789 2176-2192 JJ denotes signal-regulated
T1788 2162-2175 JJ denotes extracellular
T1787 2158-2161 CC denotes and
T1786 2148-2157 NN denotes protein-1
T1785 2138-2147 NN denotes activator
T1784 2135-2137 IN denotes of
T1783 2124-2134 NN denotes inhibition
T1782 2122-2123 , denotes ,
T1781 2115-2122 RB denotes However
T1780 2113-2114 . denotes .
T1779 2101-2113 RB denotes respectively
T1778 2099-2100 , denotes ,
T1777 2091-2099 NNP denotes LY294002
T1776 2087-2090 CC denotes and
T1775 2076-2086 NN denotes wortmannin
T1774 2066-2075 NN denotes inhibitor
T1773 2057-2065 JJ denotes PI3K/Akt
T1772 2053-2056 DT denotes the
T1771 2049-2052 CC denotes and
T1770 2033-2048 NN denotes dithiocarbamate
T1769 2021-2032 NN denotes pyrrolidine
T1768 2011-2020 NN denotes inhibitor
T1767 2005-2010 NNP denotes NF-κB
T1766 2001-2004 DT denotes the
T1765 1998-2000 IN denotes of
T1764 1989-1997 NN denotes presence
T1763 1985-1988 DT denotes the
T1762 1982-1984 IN denotes in
T1761 1974-1981 VBN denotes blocked
T1760 1967-1973 RB denotes partly
T1759 1964-1966 CC denotes or
T1758 1953-1963 RB denotes completely
T1757 1950-1952 VBZ denotes is
T1756 1945-1949 NNP denotes PBMC
T1755 1942-1944 NNP denotes RA
T1754 1932-1941 VBN denotes activated
T1753 1929-1931 IN denotes by
T1752 1918-1928 NN denotes production
T1751 1912-1917 NN denotes IL-17
T1750 1910-1911 . denotes .
T1749 1902-1910 NN denotes activity
T1748 1890-1901 JJ denotes DNA-binding
T1747 1888-1889 -RRB- denotes )
T1746 1883-1888 NNP denotes NF-κB
T1745 1882-1883 -LRB- denotes (
T1744 1879-1881 NNP denotes κB
T1743 1872-1878 NN denotes factor
T1742 1864-1871 JJ denotes nuclear
T1741 1861-1863 IN denotes of
T1740 1848-1860 NN denotes augmentation
T1739 1837-1847 JJ denotes pronounced
T1738 1835-1836 DT denotes a
T1737 1832-1834 IN denotes in
T1736 1823-1831 VBD denotes resulted
T1735 1815-1822 NN denotes pathway
T1734 1810-1814 DT denotes this
T1733 1807-1809 IN denotes of
T1732 1796-1806 NN denotes activation
T1731 1794-1795 : denotes ;
T1730 1787-1794 NN denotes pathway
T1729 1778-1786 JJ denotes PI3K/Akt
T1728 1774-1777 DT denotes the
T1727 1764-1773 VBD denotes activated
T1726 1755-1763 NN denotes antibody
T1725 1746-1754 JJ denotes Anti-CD3
T1724 1744-1745 . denotes .
T1723 1740-1744 NNP denotes PBMC
T1722 1737-1739 NNP denotes RA
T1721 1734-1736 IN denotes of
T1720 1728-1733 DT denotes those
T1719 1723-1727 IN denotes than
T1718 1717-1722 JJR denotes lower
T1717 1712-1716 RB denotes much
T1716 1707-1711 VBD denotes were
T1715 1700-1706 NNS denotes levels
T1714 1689-1699 NN denotes expression
T1713 1683-1688 PRP$ denotes their
T1712 1679-1682 CC denotes but
T1711 1677-1678 , denotes ,
T1710 1663-1677 NNS denotes osteoarthritis
T1709 1658-1662 IN denotes with
T1708 1649-1657 NNS denotes patients
T1707 1646-1648 IN denotes of
T1706 1641-1645 NNP denotes PBMC
T1705 1637-1640 DT denotes the
T1704 1634-1636 IN denotes in
T1703 1625-1633 VBN denotes detected
T1702 1620-1624 RB denotes also
T1701 1616-1619 VBD denotes was
T1700 1610-1615 NNP denotes IL-17
T1699 1608-1609 . denotes .
T1698 1605-1608 RB denotes not
T1697 1601-1604 VBD denotes did
T1696 1592-1600 NN denotes factor-β
T1695 1585-1591 NN denotes growth
T1694 1572-1584 VBG denotes transforming
T1693 1569-1571 CC denotes or
T1692 1563-1568 NN denotes IL-18
T1691 1561-1562 , denotes ,
T1690 1556-1561 NN denotes IL-1β
T1689 1554-1555 , denotes ,
T1688 1546-1554 NN denotes factor-α
T1687 1537-1545 NN denotes necrosis
T1686 1531-1536 NN denotes tumor
T1685 1523-1530 IN denotes whereas
T1684 1521-1522 , denotes ,
T1683 1520-1521 -RRB- denotes )
T1682 1516-1520 CD denotes 0.05
T1681 1514-1515 CD denotes <
T1680 1512-1513 NNP denotes P
T1679 1511-1512 -LRB- denotes (
T1678 1500-1510 NN denotes production
T1677 1494-1499 JJ denotes IL-17
T1676 1482-1493 VBD denotes upregulated
T1675 1477-1481 NN denotes IL-6
T1674 1473-1476 CC denotes and
T1673 1463-1472 NN denotes protein-1
T1672 1447-1462 NN denotes chemoattractant
T1671 1438-1446 NN denotes monocyte
T1670 1436-1437 , denotes ,
T1669 1431-1436 NNP denotes IL-15
T1479 273-284 NNP denotes Interleukin
T1478 271-272 . denotes .
T1477 270-271 -RRB- denotes )
T1476 268-270 NNP denotes RA
T1475 267-268 -LRB- denotes (
T1474 257-266 NNS denotes arthritis
T1473 246-256 JJ denotes rheumatoid
T1472 243-245 IN denotes of
T1471 230-242 NN denotes pathogenesis
T1470 226-229 DT denotes the
T1469 223-225 IN denotes in
T1468 213-222 JJ denotes important
T1467 207-212 VBG denotes being
T1466 204-206 IN denotes as
T1465 193-203 VBN denotes recognized
T1464 188-192 VBN denotes been
T1463 183-187 VBP denotes have
T1462 173-182 NNS denotes mediators
T1461 160-172 JJ denotes Inflammatory
T1668 1429-1430 , denotes ,
T1667 1419-1429 NNS denotes chemokines
T1666 1415-1418 CC denotes and
T1665 1405-1414 NNS denotes cytokines
T1664 1398-1404 VBN denotes tested
T1663 1392-1397 IN denotes Among
T1662 1390-1391 . denotes .
T1661 1389-1390 -RRB- denotes )
T1660 1385-1389 CD denotes 0.05
T1659 1383-1384 CD denotes <
T1658 1381-1382 NNP denotes P
T1657 1380-1381 -LRB- denotes (
T1656 1376-1379 NNP denotes PHA
T1655 1372-1375 CC denotes and
T1654 1362-1371 JJ denotes anti-CD28
T1653 1354-1361 IN denotes without
T1652 1351-1353 CC denotes or
T1651 1346-1350 IN denotes with
T1650 1337-1345 NN denotes antibody
T1649 1328-1336 JJ denotes anti-CD3
T1648 1323-1327 IN denotes with
T1647 1315-1322 VBN denotes treated
T1646 1309-1314 NNS denotes cells
T1645 1306-1308 IN denotes in
T1644 1296-1305 VBN denotes increased
T1643 1282-1295 RB denotes significantly
T1642 1278-1281 VBD denotes was
T1641 1272-1277 NNP denotes IL-17
T1640 1269-1271 IN denotes of
T1639 1258-1268 NN denotes production
T1638 1254-1257 DT denotes The
T1637 1252-1253 . denotes .
T1636 1244-1252 NN denotes reaction
T1635 1238-1243 NN denotes chain
T1634 1227-1237 NN denotes polymerase
T1633 1213-1226 NN denotes transcription
T1632 1205-1212 VB denotes reverse
T1631 1201-1204 CC denotes and
T1630 1195-1200 NN denotes assay
T1629 1181-1194 JJ denotes immunosorbent
T1628 1167-1180 JJ denotes enzyme-linked
T1627 1158-1166 NN denotes sandwich
T1626 1155-1157 IN denotes by
T1625 1144-1154 VBN denotes determined
T1624 1139-1143 VBD denotes were
T1623 1132-1138 NNS denotes levels
T1622 1126-1131 NN denotes IL-17
T1621 1124-1125 . denotes .
T1620 1114-1124 NNS denotes chemokines
T1619 1110-1113 CC denotes and
T1618 1100-1109 NNS denotes cytokines
T1617 1087-1099 JJ denotes inflammatory
T1616 1079-1086 JJ denotes several
T1615 1075-1078 CC denotes and
T1614 1073-1074 -RRB- denotes )
T1613 1070-1073 NNP denotes PHA
T1612 1069-1070 -LRB- denotes (
T1611 1050-1068 NN denotes phytohemagglutinin
T1610 1048-1049 , denotes ,
T1609 1039-1048 JJ denotes anti-CD28
T1608 1037-1038 , denotes ,
T1607 1029-1037 JJ denotes anti-CD3
T1606 1019-1028 VBG denotes including
T1605 1012-1018 NNS denotes agents
T1604 1004-1011 JJ denotes various
T1603 999-1003 IN denotes with
T1602 988-998 VBN denotes stimulated
T1601 983-987 RB denotes then
T1600 981-982 , denotes ,
T1599 972-981 VBN denotes separated
T1598 967-971 VBD denotes were
T1597 965-966 -RRB- denotes )
T1596 963-965 CD denotes 24
T1595 961-962 SYM denotes =
T1594 959-960 FW denotes n
T1593 958-959 -LRB- denotes (
T1592 955-957 NNP denotes RA
T1591 950-954 IN denotes with
T1590 941-949 NNS denotes patients
T1589 936-940 IN denotes from
T1588 934-935 -RRB- denotes )
T1587 930-934 NNP denotes PBMC
T1586 929-930 -LRB- denotes (
T1585 923-928 NNS denotes cells
T1584 911-922 NN denotes mononuclear
T1583 905-910 NN denotes blood
T1582 894-904 JJ denotes Peripheral
T1581 892-893 . denotes .
T1580 890-892 NNP denotes RA
T1579 887-889 IN denotes in
T1578 876-886 NN denotes production
T1577 870-875 JJ denotes IL-17
T1576 867-869 IN denotes of
T1575 856-866 NN denotes regulation
T1574 852-855 DT denotes the
T1573 849-851 IN denotes in
T1572 841-848 NN denotes pathway
T1571 837-840 NNP denotes Akt
T1570 836-837 VBP denotes /
T1569 835-836 -RRB- denotes )
T1568 831-835 NNP denotes PI3K
T1567 830-831 -LRB- denotes (
T1566 821-829 JJ denotes 3-kinase
T1565 804-820 NN denotes phosphoinositide
T1564 800-803 DT denotes the
T1563 797-799 IN denotes of
T1562 792-796 NN denotes role
T1561 788-791 DT denotes the
T1560 775-787 VBD denotes investigated
T1559 772-774 PRP denotes we
T1558 770-771 , denotes ,
T1557 765-770 NN denotes study
T1556 757-764 JJ denotes present
T1555 753-756 DT denotes the
T1554 750-752 IN denotes In
T1553 748-749 . denotes .
T1552 741-748 JJ denotes unknown
T1551 734-740 VBP denotes remain
T1550 723-733 NN denotes production
T1549 717-722 JJ denotes IL-17
T1548 708-716 VBP denotes regulate
T1547 703-707 WDT denotes that
T1546 694-702 NNS denotes pathways
T1545 684-693 VBG denotes signaling
T1544 670-683 JJ denotes intracellular
T1543 666-669 DT denotes the
T1542 664-665 , denotes ,
T1541 654-664 NN denotes production
T1540 648-653 JJ denotes IL-17
T1539 639-647 VB denotes regulate
T1538 636-638 TO denotes to
T1537 627-635 VBN denotes reported
T1536 622-626 VBN denotes been
T1535 617-621 VBP denotes have
T1534 615-616 -RRB- denotes )
T1533 610-615 NN denotes IL-23
T1532 606-609 CC denotes and
T1531 600-605 NN denotes IL-15
T1530 599-600 -LRB- denotes (
T1529 589-598 NNS denotes cytokines
T1528 584-588 DT denotes some
T1527 575-583 IN denotes Although
T1526 573-574 . denotes .
T1525 571-573 NNP denotes RA
T1524 568-570 IN denotes of
T1523 561-567 NNS denotes models
T1522 554-560 NN denotes animal
T1521 551-553 IN denotes in
T1520 547-550 CC denotes and
T1519 538-546 NN denotes synovium
T1518 535-537 NNP denotes RA
T1517 532-534 IN denotes in
T1516 519-531 VBN denotes demonstrated
T1515 514-518 VBN denotes been
T1514 510-513 VBZ denotes has
T1513 504-509 NNP denotes IL-17
T1512 501-503 IN denotes of
T1511 492-500 NN denotes activity
T1510 476-491 JJ denotes proinflammatory
T1509 472-475 CC denotes and
T1505 444-452 NN denotes Evidence
T1504 442-443 . denotes .
T1503 432-442 NN denotes resorption
T1502 427-431 NN denotes bone
T1501 414-426 JJ denotes osteoclastic
T1500 410-413 CC denotes and
T1499 400-409 NNS denotes cytokines
T1498 384-399 JJ denotes proinflammatory
T1497 381-383 IN denotes of
T1496 371-380 NN denotes induction
T1495 367-370 DT denotes the
T1494 357-366 VBG denotes including
T1493 355-356 , denotes ,
T1492 346-355 NNS denotes responses
T1491 333-345 JJ denotes inflammatory
T1490 329-332 CC denotes and
T1489 322-328 JJ denotes immune
T1488 319-321 IN denotes of
T1487 309-318 NN denotes regulator
T1486 299-308 JJ denotes important
T1485 296-298 DT denotes an
T1484 293-295 VBZ denotes is
T1483 289-292 CD denotes -17
T1482 288-289 -RRB- denotes )
T1481 286-288 NNP denotes IL
T1480 285-286 -LRB- denotes (
T14641 19534-19535 . denotes .
T14640 19525-19534 VBN denotes performed
T14639 19521-19524 VBD denotes was
T14638 19512-19520 NN denotes reaction
T14637 19506-19511 NN denotes chain
T14636 19495-19505 NN denotes polymerase
T14635 19481-19494 NN denotes transcription
T14634 19473-19480 NN denotes reverse
T14633 19455-19472 JJ denotes semi-quantatitive
T14632 19453-19454 , denotes ,
T14631 19448-19453 NN denotes level
T14630 19432-19447 JJ denotes transcriptional
T14629 19430-19431 DT denotes a
T14628 19427-19429 IN denotes at
T14627 19417-19426 VBN denotes regulated
T14626 19414-19416 VB denotes be
T14625 19408-19413 MD denotes could
T14624 19397-19407 NN denotes production
T6313 7411-7425 NNP denotes Ficoll-Hypaque
T6312 7408-7410 IN denotes by
T6311 7402-7407 NN denotes blood
T6310 7390-7401 VBN denotes heparinized
T6309 7385-7389 IN denotes from
T6308 7376-7384 VBN denotes prepared
T6307 7371-7375 VBD denotes were
T6306 7366-7370 NNP denotes PBMC
T6305 7355-7365 NNS denotes chemokines
T6304 7352-7354 CC denotes or
T6303 7342-7351 NNS denotes cytokines
T6302 7340-7341 , denotes ,
T6301 7330-7340 NN denotes activation
T6300 7321-7329 NN denotes receptor
T6299 7316-7320 NN denotes cell
T6298 7314-7315 NNP denotes T
T6297 7311-7313 IN denotes by
T6296 7305-7310 NNP denotes IL-17
T6295 7302-7304 IN denotes of
T6294 7291-7301 NN denotes Production
T6356 7661-7664 CD denotes 100
T6355 7659-7660 , denotes ,
T6354 7654-7659 NN denotes serum
T6353 7649-7653 NN denotes calf
T6352 7643-7648 JJ denotes fetal
T6351 7641-7642 NN denotes %
T6350 7639-7641 CD denotes 10
T6349 7634-7638 IN denotes with
T6348 7621-7633 VBN denotes supplemented
T6347 7614-7620 JJ denotes medium
T6346 7609-7613 CD denotes 1640
T6345 7604-7608 NNP denotes RPMI
T6344 7601-7603 IN denotes in
T6343 7594-7600 CD denotes 106/ml
T6342 7591-7593 IN denotes of
T6341 7577-7590 NN denotes concentration
T6340 7575-7576 DT denotes a
T6374 7750-7753 VBD denotes was
T6373 7748-7749 -RRB- denotes )
T6372 7746-7748 NN denotes ml
T6371 7744-7745 CD denotes 1
T6370 7743-7744 -LRB- denotes (
T6369 7732-7742 NN denotes suspension
T6368 7727-7731 NNP denotes Cell
T6367 7725-7726 . denotes .
T6366 7714-7725 NNP denotes L-glutamine
T6365 7711-7713 NNP denotes mM
T6364 7709-7710 CD denotes 2
T6363 7705-7708 CC denotes and
T6362 7692-7704 NN denotes streptomycin
T6361 7686-7691 JJ denotes mg/ml
T6360 7682-7685 CD denotes 100
T6359 7680-7681 , denotes ,
T6358 7670-7680 NN denotes penicillin
T6357 7665-7669 NNP denotes U/ml
T11451 15591-15600 VBN denotes separated
T11450 15586-15590 VBD denotes were
T11449 15581-15585 NNP denotes PBMC
T11448 15569-15580 NNS denotes individuals
T11447 15562-15568 JJ denotes normal
T11446 15558-15561 CC denotes and
T11445 15555-15557 NNP denotes OA
T11444 15550-15554 IN denotes with
T11443 15541-15549 NNS denotes patients
T11442 15539-15540 , denotes ,
T11441 15537-15539 NNP denotes RA
T11440 15532-15536 IN denotes with
T11439 15523-15531 NNS denotes patients
T11438 15518-15522 IN denotes from
T11437 15513-15517 NNP denotes PBMC
T11436 15510-15512 IN denotes in
T11435 15499-15509 NN denotes production
T8027 10421-10422 -RRB- denotes )
T8026 10416-10421 NNP denotes Sigma
T8025 10415-10416 -LRB- denotes (
T8024 10400-10414 NN denotes diethanolamine
T8023 10397-10399 IN denotes in
T8022 10387-10396 VBN denotes dissolved
T8021 10385-10386 -RRB- denotes )
T8020 10380-10385 NNP denotes Sigma
T8019 10379-10380 -LRB- denotes (
T8018 10369-10378 NN denotes phosphate
T8017 10355-10368 NN denotes p-nitrophenyl
T8016 10349-10354 NN denotes mg/ml
T8015 10347-10348 CD denotes 1
T13088 17514-17519 NN denotes ng/ml
T21144 26306-26315 NN denotes mechanism
T21143 26304-26305 DT denotes a
T21142 26301-26303 IN denotes by
T21141 26295-26300 NN denotes NF-κB
T21140 26285-26294 VB denotes stimulate
T21145 26316-26325 VBG denotes involving
T21151 26371-26373 CD denotes 33
T21150 26370-26371 NNP denotes [
T21149 26362-26369 NN denotes protein
T21148 26344-26361 JJ denotes p300/CREB-binding
T21147 26334-26343 NN denotes acetylase
T21146 26326-26333 NN denotes histone
T1506 453-456 IN denotes for
T21241 26866-26869 NNP denotes Akt
T21240 26861-26865 IN denotes that
T21239 26856-26860 NN denotes fact
T21238 26852-26855 DT denotes The
T21237 26850-26851 . denotes .
T1507 457-460 DT denotes the
T1508 461-471 NN denotes expression
T5124 6088-6091 NNS denotes men
R4659 T8938 T8944 compound ACT,TTG-3
R4660 T8939 T8941 compound CCT,AAG
R4661 T8940 T8941 compound GGG,AAG
R4662 T8941 T8944 compound AAG,TTG-3
R4663 T8942 T8944 compound ACC,TTG-3
R4664 T8943 T8944 compound TCA,TTG-3
R8454 T15339 T15337 punct ),lane
R8455 T15340 T15323 conj reached,increased
R8456 T15341 T15342 det a,peak
R8457 T15342 T15340 dobj peak,reached
R8458 T15343 T15340 prep at,reached
R8459 T15344 T15345 nummod 60,min
R8460 T15345 T15343 pobj min,at
R8461 T15346 T15340 punct ",",reached
R8462 T15347 T15340 advcl lasting,reached
R8463 T15348 T15347 prep to,lasting
R8464 T15349 T15350 quantmod 120,240
R8465 T15350 T15351 nummod 240,min
R8466 T15351 T15348 pobj min,to
R633 T1477 T1471 punct ),pathogenesis
R634 T1478 T1465 punct .,recognized
R635 T1479 T1483 nmod Interleukin,-17
R636 T1480 T1481 punct (,IL
R637 T1481 T1479 appos IL,Interleukin
R638 T1482 T1483 punct ),-17
R639 T1483 T1484 nsubj -17,is
R640 T1484 T1484 ROOT is,is
R641 T1485 T1487 det an,regulator
R642 T1486 T1487 amod important,regulator
R643 T1487 T1484 attr regulator,is
R644 T1488 T1487 prep of,regulator
R645 T1489 T1492 amod immune,responses
R646 T1490 T1489 cc and,immune
R647 T1491 T1489 conj inflammatory,immune
R648 T1492 T1488 pobj responses,of
R649 T1493 T1492 punct ",",responses
R650 T1494 T1492 prep including,responses
R651 T1495 T1496 det the,induction
R652 T1496 T1494 pobj induction,including
R653 T1497 T1496 prep of,induction
R654 T1498 T1499 amod proinflammatory,cytokines
R655 T1499 T1497 pobj cytokines,of
R656 T1500 T1499 cc and,cytokines
R657 T1501 T1503 amod osteoclastic,resorption
R658 T1502 T1503 compound bone,resorption
R659 T1503 T1499 conj resorption,cytokines
R660 T1504 T1484 punct .,is
R661 T1505 T1516 nsubjpass Evidence,demonstrated
R662 T1509 T1508 cc and,expression
R663 T1510 T1511 amod proinflammatory,activity
R664 T1511 T1508 conj activity,expression
R665 T1512 T1508 prep of,expression
R666 T1513 T1512 pobj IL-17,of
R667 T1514 T1516 aux has,demonstrated
R668 T1515 T1516 auxpass been,demonstrated
R669 T1516 T1516 ROOT demonstrated,demonstrated
R670 T1517 T1516 prep in,demonstrated
R671 T1518 T1519 compound RA,synovium
R672 T1519 T1517 pobj synovium,in
R673 T1520 T1517 cc and,in
R674 T1521 T1517 conj in,in
R675 T1522 T1523 compound animal,models
R676 T1523 T1521 pobj models,in
R677 T1524 T1523 prep of,models
R678 T1525 T1524 pobj RA,of
R679 T1526 T1516 punct .,demonstrated
R680 T1527 T1537 mark Although,reported
R681 T1528 T1529 det some,cytokines
R682 T1529 T1537 nsubjpass cytokines,reported
R683 T1530 T1529 punct (,cytokines
R684 T1531 T1529 appos IL-15,cytokines
R685 T1532 T1531 cc and,IL-15
R686 T1533 T1531 conj IL-23,IL-15
R687 T1534 T1529 punct ),cytokines
R688 T1535 T1537 aux have,reported
R689 T1536 T1537 auxpass been,reported
R690 T1537 T1551 advcl reported,remain
R691 T1538 T1539 aux to,regulate
R692 T1539 T1537 xcomp regulate,reported
R693 T1540 T1541 compound IL-17,production
R694 T1541 T1539 dobj production,regulate
R695 T1542 T1551 punct ",",remain
R696 T1543 T1546 det the,pathways
R697 T1544 T1545 nsubj intracellular,signaling
R698 T1545 T1546 compound signaling,pathways
R699 T1546 T1551 nsubj pathways,remain
R700 T1547 T1548 nsubj that,regulate
R701 T1548 T1546 relcl regulate,pathways
R702 T1549 T1550 compound IL-17,production
R703 T1550 T1548 dobj production,regulate
R704 T1551 T1551 ROOT remain,remain
R705 T1552 T1551 acomp unknown,remain
R706 T1553 T1551 punct .,remain
R707 T1554 T1560 prep In,investigated
R708 T1555 T1557 det the,study
R709 T1556 T1557 amod present,study
R710 T1557 T1554 pobj study,In
R711 T1558 T1560 punct ",",investigated
R712 T1559 T1560 nsubj we,investigated
R713 T1560 T1560 ROOT investigated,investigated
R714 T1561 T1562 det the,role
R715 T1562 T1560 dobj role,investigated
R716 T1563 T1562 prep of,role
R717 T1564 T1566 det the,3-kinase
R718 T1565 T1566 compound phosphoinositide,3-kinase
R719 T1566 T1563 pobj 3-kinase,of
R720 T1567 T1566 punct (,3-kinase
R721 T1568 T1566 appos PI3K,3-kinase
R722 T1569 T1566 punct ),3-kinase
R723 T1570 T1571 compound /,Akt
R724 T1571 T1572 compound Akt,pathway
R725 T1572 T1562 conj pathway,role
R726 T1573 T1562 prep in,role
R727 T1574 T1575 det the,regulation
R728 T1575 T1573 pobj regulation,in
R729 T1576 T1575 prep of,regulation
R730 T1577 T1578 amod IL-17,production
R731 T1578 T1576 pobj production,of
R732 T1579 T1578 prep in,production
R733 T1580 T1579 pobj RA,in
R734 T1581 T1560 punct .,investigated
R735 T1582 T1585 amod Peripheral,cells
R736 T1583 T1585 compound blood,cells
R737 T1584 T1585 compound mononuclear,cells
R738 T1585 T1599 nsubjpass cells,separated
R739 T1586 T1585 punct (,cells
R740 T1587 T1585 appos PBMC,cells
R741 T1588 T1585 punct ),cells
R742 T1589 T1585 prep from,cells
R743 T1590 T1589 pobj patients,from
R744 T1591 T1585 prep with,cells
R745 T1592 T1591 pobj RA,with
R746 T1593 T1592 punct (,RA
R747 T1594 T1596 nmod n,24
R748 T1595 T1596 punct =,24
R749 T1596 T1592 appos 24,RA
R750 T1597 T1592 punct ),RA
R751 T1598 T1599 auxpass were,separated
R752 T1599 T1599 ROOT separated,separated
R753 T1600 T1599 punct ",",separated
R754 T1601 T1602 advmod then,stimulated
R755 T1602 T1599 conj stimulated,separated
R756 T1603 T1602 prep with,stimulated
R757 T1604 T1605 amod various,agents
R758 T1605 T1603 pobj agents,with
R759 T1606 T1605 prep including,agents
R760 T1607 T1618 amod anti-CD3,cytokines
R761 T1608 T1607 punct ",",anti-CD3
R762 T1609 T1607 conj anti-CD28,anti-CD3
R763 T1610 T1607 punct ",",anti-CD3
R764 T1611 T1607 conj phytohemagglutinin,anti-CD3
R765 T1612 T1611 punct (,phytohemagglutinin
R766 T1613 T1611 appos PHA,phytohemagglutinin
R767 T1614 T1611 punct ),phytohemagglutinin
R768 T1615 T1611 cc and,phytohemagglutinin
R769 T1616 T1618 amod several,cytokines
R770 T1617 T1618 amod inflammatory,cytokines
R771 T1618 T1606 pobj cytokines,including
R772 T1619 T1618 cc and,cytokines
R773 T1620 T1618 conj chemokines,cytokines
R774 T1621 T1599 punct .,separated
R775 T1622 T1623 compound IL-17,levels
R776 T1623 T1625 nsubjpass levels,determined
R777 T1624 T1625 auxpass were,determined
R778 T1625 T1625 ROOT determined,determined
R779 T1626 T1625 agent by,determined
R780 T1627 T1630 nmod sandwich,assay
R781 T1628 T1630 nmod enzyme-linked,assay
R782 T1629 T1630 compound immunosorbent,assay
R783 T1630 T1626 pobj assay,by
R784 T1631 T1630 cc and,assay
R785 T1632 T1630 conj reverse,assay
R786 T1633 T1632 dobj transcription,reverse
R787 T1634 T1636 compound polymerase,reaction
R788 T1635 T1636 compound chain,reaction
R789 T1636 T1630 appos reaction,assay
R790 T1637 T1625 punct .,determined
R791 T1707 T1706 prep of,PBMC
R792 T1638 T1639 det The,production
R793 T1708 T1707 pobj patients,of
R794 T1639 T1644 nsubjpass production,increased
R795 T1709 T1708 prep with,patients
R796 T1710 T1709 pobj osteoarthritis,with
R797 T1711 T1703 punct ",",detected
R798 T1640 T1639 prep of,production
R799 T1712 T1703 cc but,detected
R800 T1713 T1715 poss their,levels
R801 T1714 T1715 compound expression,levels
R802 T1641 T1640 pobj IL-17,of
R803 T1642 T1644 auxpass was,increased
R804 T1643 T1644 advmod significantly,increased
R805 T1644 T1644 ROOT increased,increased
R806 T1645 T1644 prep in,increased
R807 T1715 T1716 nsubj levels,were
R808 T1716 T1703 conj were,detected
R809 T1646 T1645 pobj cells,in
R810 T1717 T1718 advmod much,lower
R811 T1718 T1716 acomp lower,were
R812 T1719 T1718 prep than,lower
R813 T1720 T1719 pobj those,than
R814 T1721 T1720 prep of,those
R815 T1722 T1723 compound RA,PBMC
R816 T1723 T1721 pobj PBMC,of
R817 T1647 T1646 acl treated,cells
R818 T1724 T1716 punct .,were
R819 T1725 T1726 amod Anti-CD3,antibody
R820 T1726 T1727 nsubj antibody,activated
R821 T1727 T1727 ROOT activated,activated
R822 T1648 T1647 prep with,treated
R823 T1728 T1730 det the,pathway
R824 T1729 T1730 amod PI3K/Akt,pathway
R825 T1730 T1727 dobj pathway,activated
R826 T1649 T1650 amod anti-CD3,antibody
R827 T1731 T1730 punct ;,pathway
R828 T1732 T1736 nsubj activation,resulted
R829 T1733 T1732 prep of,activation
R830 T1650 T1648 pobj antibody,with
R831 T1734 T1735 det this,pathway
R832 T1735 T1733 pobj pathway,of
R833 T1651 T1648 conj with,with
R834 T1736 T1727 conj resulted,activated
R835 T1737 T1736 prep in,resulted
R836 T1738 T1740 det a,augmentation
R837 T1739 T1740 amod pronounced,augmentation
R838 T1652 T1651 cc or,with
R839 T1740 T1737 pobj augmentation,in
R840 T1741 T1740 prep of,augmentation
R841 T1742 T1743 amod nuclear,factor
R842 T1653 T1651 conj without,with
R843 T1743 T1741 pobj factor,of
R844 T1744 T1749 nmod κB,activity
R845 T1745 T1746 punct (,NF-κB
R846 T1654 T1653 pobj anti-CD28,without
R847 T1746 T1744 appos NF-κB,κB
R848 T1747 T1749 punct ),activity
R849 T1748 T1749 amod DNA-binding,activity
R850 T1655 T1654 cc and,anti-CD28
R851 T1749 T1740 appos activity,augmentation
R852 T1750 T1736 punct .,resulted
R853 T1751 T1752 compound IL-17,production
R854 T1656 T1654 conj PHA,anti-CD28
R855 T1752 T1757 nsubj production,is
R856 T1753 T1752 prep by,production
R857 T1657 T1656 punct (,PHA
R858 T1754 T1756 amod activated,PBMC
R859 T1755 T1756 compound RA,PBMC
R860 T1756 T1753 pobj PBMC,by
R861 T1757 T1761 auxpass is,blocked
R862 T1758 T1761 advmod completely,blocked
R863 T1759 T1758 cc or,completely
R864 T1760 T1758 conj partly,completely
R865 T1658 T1656 nmod P,PHA
R866 T1761 T1761 ROOT blocked,blocked
R867 T1762 T1761 prep in,blocked
R868 T1763 T1764 det the,presence
R869 T1764 T1762 pobj presence,in
R870 T1659 T1658 nummod <,P
R871 T1765 T1764 prep of,presence
R872 T1766 T1768 det the,inhibitor
R873 T1767 T1768 compound NF-κB,inhibitor
R874 T1660 T1658 nummod 0.05,P
R875 T1768 T1765 pobj inhibitor,of
R876 T1769 T1770 compound pyrrolidine,dithiocarbamate
R877 T1770 T1764 appos dithiocarbamate,presence
R878 T1661 T1656 punct ),PHA
R879 T1771 T1770 cc and,dithiocarbamate
R880 T1772 T1775 det the,wortmannin
R881 T1773 T1775 amod PI3K/Akt,wortmannin
R882 T1662 T1644 punct .,increased
R883 T1774 T1775 compound inhibitor,wortmannin
R884 T1663 T1676 prep Among,upregulated
R885 T1775 T1770 conj wortmannin,dithiocarbamate
R886 T1776 T1775 cc and,wortmannin
R887 T1777 T1775 conj LY294002,wortmannin
R888 T1778 T1777 punct ",",LY294002
R889 T1664 T1665 amod tested,cytokines
R890 T1779 T1770 conj respectively,dithiocarbamate
R891 T1780 T1761 punct .,blocked
R892 T1781 T1794 advmod However,affect
R893 T1665 T1663 pobj cytokines,Among
R894 T1782 T1794 punct ",",affect
R895 T1783 T1794 nsubj inhibition,affect
R896 T1784 T1783 prep of,inhibition
R897 T1666 T1665 cc and,cytokines
R898 T1785 T1786 amod activator,protein-1
R899 T1786 T1784 pobj protein-1,of
R900 T1787 T1786 cc and,protein-1
R901 T1667 T1665 conj chemokines,cytokines
R902 T1788 T1791 nmod extracellular,1/2
R903 T1789 T1791 amod signal-regulated,1/2
R904 T1790 T1791 compound kinase,1/2
R905 T1668 T1667 punct ",",chemokines
R906 T1791 T1786 conj 1/2,protein-1
R907 T1792 T1794 aux did,affect
R908 T1793 T1794 neg not,affect
R909 T1669 T1676 nsubj IL-15,upregulated
R910 T1670 T1669 punct ",",IL-15
R911 T1671 T1673 nmod monocyte,protein-1
R912 T1794 T1794 ROOT affect,affect
R913 T1795 T1796 amod IL-17,production
R914 T1796 T1794 dobj production,affect
R915 T1797 T1794 punct .,affect
R916 T1672 T1673 compound chemoattractant,protein-1
R917 T1798 T1799 det These,results
R918 T1799 T1800 nsubj results,suggest
R919 T1800 T1800 ROOT suggest,suggest
R920 T1673 T1669 appos protein-1,IL-15
R921 T1801 T1811 mark that,involved
R922 T1802 T1811 nsubjpass signal,involved
R923 T1803 T1804 compound transduction,pathways
R924 T1674 T1673 cc and,protein-1
R925 T1804 T1811 nsubjpass pathways,involved
R926 T1805 T1804 amod dependent,pathways
R927 T1806 T1805 prep on,dependent
R928 T1675 T1673 conj IL-6,protein-1
R929 T1807 T1806 pobj PI3K/Akt,on
R930 T1808 T1807 cc and,PI3K/Akt
R931 T1809 T1807 conj NF-κB,PI3K/Akt
R932 T1676 T1676 ROOT upregulated,upregulated
R933 T1810 T1811 auxpass are,involved
R934 T1811 T1800 ccomp involved,suggest
R935 T1812 T1811 prep in,involved
R936 T1677 T1678 amod IL-17,production
R937 T1813 T1814 det the,overproduction
R938 T1678 T1676 dobj production,upregulated
R939 T1679 T1678 punct (,production
R940 T1680 T1678 appos P,production
R941 T1681 T1680 nummod <,P
R942 T1682 T1680 nummod 0.05,P
R943 T1683 T1678 punct ),production
R944 T1814 T1812 pobj overproduction,in
R945 T1815 T1814 prep of,overproduction
R946 T1816 T1820 det the,IL-17
R947 T1684 T1676 punct ",",upregulated
R948 T1817 T1820 amod key,IL-17
R949 T1818 T1819 amod inflammatory,cytokine
R950 T1819 T1820 compound cytokine,IL-17
R951 T1685 T1697 mark whereas,did
R952 T1820 T1815 pobj IL-17,of
R953 T1821 T1820 prep in,IL-17
R954 T1686 T1688 compound tumor,factor-α
R955 T1822 T1821 pobj RA,in
R956 T1823 T1800 punct .,suggest
R957 T1687 T1688 compound necrosis,factor-α
R958 T1688 T1697 nsubj factor-α,did
R959 T1689 T1690 punct ",",IL-1β
R960 T1690 T1688 appos IL-1β,factor-α
R961 T1691 T1690 punct ",",IL-1β
R962 T1692 T1690 conj IL-18,IL-1β
R963 T1693 T1692 cc or,IL-18
R964 T1694 T1692 conj transforming,IL-18
R965 T1695 T1696 compound growth,factor-β
R966 T1696 T1694 dobj factor-β,transforming
R967 T1697 T1676 advcl did,upregulated
R970 T1698 T1697 neg not,did
R971 T1699 T1697 punct .,did
R972 T1700 T1703 nsubjpass IL-17,detected
R974 T1701 T1703 auxpass was,detected
R975 T1702 T1703 advmod also,detected
R976 T1703 T1703 ROOT detected,detected
R977 T1704 T1703 prep in,detected
R980 T1705 T1706 det the,PBMC
R982 T1706 T1704 pobj PBMC,in
R1064 T1506 T1505 prep for,Evidence
R1065 T1507 T1508 det the,expression
R1066 T1508 T1506 pobj expression,for
R1821 T3852 T3853 amod Rheumatoid,arthritis
R1822 T3853 T3858 nsubjpass arthritis,characterized
R1823 T3854 T3853 punct (,arthritis
R1824 T3855 T3853 appos RA,arthritis
R1828 T3856 T3853 punct ),arthritis
R1829 T3857 T3858 auxpass is,characterized
R1832 T3858 T3858 ROOT characterized,characterized
R1833 T3859 T3858 agent by,characterized
R1836 T3860 T3859 pobj infiltrations,by
R1838 T3861 T3860 prep of,infiltrations
R1841 T3862 T3861 pobj macrophages,of
R1843 T3863 T3862 cc and,macrophages
R1845 T3864 T3865 compound T,cells
R1846 T3865 T3862 conj cells,macrophages
R1847 T3866 T3858 prep into,characterized
R1848 T3867 T3868 det the,joint
R1849 T3868 T3872 amod joint,hyperplasia
R1850 T3869 T3868 punct ",",joint
R1851 T3948 T3964 advmod ago,was
R1852 T3870 T3868 cc and,joint
R1853 T3949 T3964 punct ",",was
R1854 T3950 T3951 det the,primacy
R1855 T3871 T3868 conj synovial,joint
R1856 T3951 T3964 nsubj primacy,was
R1857 T3952 T3951 prep of,primacy
R1858 T3872 T3866 pobj hyperplasia,into
R1859 T3953 T3954 compound T,cells
R1860 T3954 T3952 pobj cells,of
R1861 T3873 T3858 punct .,characterized
R1862 T3955 T3951 prep in,primacy
R1863 T3956 T3957 det the,pathogenesis
R1864 T3957 T3955 pobj pathogenesis,in
R1865 T3874 T3875 amod Proinflammatory,cytokines
R1866 T3958 T3957 prep of,pathogenesis
R1867 T3959 T3960 amod autoimmune,disease
R1868 T3960 T3958 pobj disease,of
R1869 T3875 T3881 nsubjpass cytokines,known
R1870 T3961 T3962 amod such,as
R1871 T3962 T3957 prep as,pathogenesis
R1872 T3963 T3964 nsubj RA,was
R1873 T3876 T3875 acl released,cytokines
R1874 T3964 T3964 ROOT was,was
R1875 T3965 T3964 acomp undisputed,was
R1876 T3966 T3968 mark because,are
R1877 T3967 T3968 nsubj they,are
R1878 T3877 T3876 prep from,released
R1879 T3968 T3964 advcl are,was
R1880 T3878 T3879 det these,cells
R1881 T3969 T3972 det the,population
R1882 T3970 T3972 amod largest,population
R1883 T3879 T3877 pobj cells,from
R1884 T3971 T3972 compound cell,population
R1885 T3972 T3968 attr population,are
R1886 T3973 T3972 acl infiltrating,population
R1887 T3880 T3881 auxpass are,known
R1888 T3974 T3975 det the,synovium
R1889 T3975 T3973 dobj synovium,infiltrating
R1890 T3976 T3964 punct .,was
R1891 T3881 T3881 ROOT known,known
R1892 T3977 T3983 advmod However,demonstrated
R1893 T3978 T3983 punct ",",demonstrated
R1894 T3882 T3883 aux to,be
R1895 T3979 T3980 det a,series
R1896 T3980 T3983 nsubj series,demonstrated
R1897 T3981 T3980 prep of,series
R1898 T3883 T3881 xcomp be,known
R1899 T3982 T3981 pobj studies,of
R1900 T3983 T3983 ROOT demonstrated,demonstrated
R1901 T3884 T3883 acomp important,be
R1902 T3984 T3983 dobj paucity,demonstrated
R1903 T3985 T3984 prep of,paucity
R1904 T3986 T3988 nmod T,cytokines
R1905 T3885 T3883 prep in,be
R1906 T3987 T3988 amod cell-derived,cytokines
R1907 T3988 T3985 pobj cytokines,of
R1908 T3989 T3990 amod such,as
R1909 T3886 T3887 det the,destruction
R1910 T3990 T3988 prep as,cytokines
R1911 T3991 T3990 pobj IL-2,as
R1912 T3992 T3991 cc and,IL-2
R1913 T3887 T3885 pobj destruction,in
R1914 T3993 T3991 conj interferon-γ,IL-2
R1915 T3994 T3983 prep in,demonstrated
R1916 T3995 T3996 det the,joints
R1917 T3996 T3994 pobj joints,in
R1918 T3888 T3887 prep of,destruction
R1919 T3997 T3996 prep of,joints
R1920 T3998 T3997 pobj RA,of
R1921 T3999 T3983 punct ",",demonstrated
R1922 T3889 T3888 pobj joints,of
R1923 T3890 T3887 prep in,destruction
R1924 T4000 T4015 mark whereas,were
R1925 T3891 T3892 compound RA,[
R1926 T4001 T4015 nsubj macrophage,were
R1927 T4002 T4001 cc and,macrophage
R1928 T4003 T4001 conj fibroblast,macrophage
R1929 T3892 T3890 pobj [,in
R1930 T4004 T4001 conj cytokines,macrophage
R1931 T4005 T4004 prep including,cytokines
R1932 T4006 T4005 pobj IL-1,including
R1933 T4007 T4006 punct ",",IL-1
R1934 T3893 T3894 nummod 1,]
R1935 T4008 T4006 conj IL-6,IL-1
R1936 T4009 T4008 punct ",",IL-6
R1937 T4010 T4008 conj IL-15,IL-6
R1938 T4011 T4010 punct ",",IL-15
R1939 T3894 T3892 appos ],[
R1940 T4012 T4010 conj IL-18,IL-15
R1941 T4013 T4012 cc and,IL-18
R1942 T3895 T3881 punct .,known
R1943 T4014 T4012 conj TNF-α,IL-18
R1944 T4015 T3983 advcl were,demonstrated
R1945 T4016 T4015 acomp abundant,were
R1946 T4017 T4016 prep in,abundant
R1947 T3896 T3899 det The,benefits
R1948 T4018 T4019 amod rheumatoid,synovium
R1949 T4019 T4017 pobj synovium,in
R1950 T4020 T3983 punct .,demonstrated
R1951 T3897 T3899 amod favorable,benefits
R1952 T4021 T4022 det This,paradox
R1953 T4022 T4024 nsubj paradox,questioned
R1954 T4023 T4024 aux has,questioned
R1955 T3898 T3899 amod clinical,benefits
R1956 T4024 T4024 ROOT questioned,questioned
R1957 T4025 T4026 det the,role
R1958 T3899 T3911 nsubj benefits,α
R1959 T4026 T4024 dobj role,questioned
R1960 T4027 T4026 prep of,role
R1961 T4028 T4029 compound T,cells
R1962 T3900 T3899 acl obtained,benefits
R1963 T4029 T4027 pobj cells,of
R1964 T4030 T4026 prep in,role
R1965 T4031 T4032 det the,pathogenesis
R1966 T3901 T3900 prep with,obtained
R1967 T4032 T4030 pobj pathogenesis,in
R1968 T4033 T4032 prep of,pathogenesis
R1969 T3902 T3901 pobj inhibitors,with
R1970 T4034 T4035 compound RA,[
R1971 T4035 T4033 pobj [,of
R1972 T4036 T4037 nummod 3,]
R1973 T3903 T3902 prep of,inhibitors
R1974 T4037 T4032 appos ],pathogenesis
R1975 T4038 T4024 punct .,questioned
R1976 T4039 T4043 mark Because,demonstrated
R1977 T3904 T3905 compound tumor,necrosis
R1978 T4040 T4043 nsubj we,demonstrated
R1979 T4041 T4043 aux have,demonstrated
R1980 T4042 T4043 advmod already,demonstrated
R1981 T4043 T4043 ROOT demonstrated,demonstrated
R1982 T4044 T4046 det the,proliferation
R1983 T3905 T3906 compound necrosis,factor
R1984 T3906 T3903 pobj factor,of
R1985 T3907 T3908 punct (,TNF
R1986 T4045 T4046 amod enhanced,proliferation
R1987 T4046 T4043 dobj proliferation,demonstrated
R1988 T3908 T3906 appos TNF,factor
R1989 T4047 T4046 prep of,proliferation
R1990 T3909 T3900 punct ),obtained
R1991 T4048 T4047 pobj antigen,of
R1992 T4049 T4051 amod specific,cells
R1993 T3910 T3899 punct -,benefits
R1994 T4050 T4051 compound T,cells
R1995 T4051 T4047 pobj cells,of
R1996 T4052 T4046 punct ",",proliferation
R1997 T3911 T3911 ROOT α,α
R1998 T4053 T4055 advmod especially,type
R1999 T4054 T4055 aux to,type
R2000 T3912 T3911 punct ),α
R2001 T4055 T4082 advcl type,needs
R2002 T4056 T4057 compound II,collagen
R2003 T4057 T4055 dobj collagen,type
R2004 T3913 T3911 cc and,α
R2005 T4058 T4055 punct ",",type
R2006 T4059 T4055 cc and,type
R2007 T4060 T4061 det the,skewing
R2008 T3914 T3919 nsubj interleukin,suggest
R2009 T4061 T4055 conj skewing,type
R2010 T4062 T4061 prep of,skewing
R2011 T4063 T4064 compound T,helper
R2012 T3915 T3916 punct (,IL
R2013 T4064 T4065 compound helper,type
R2014 T4065 T4061 conj type,skewing
R2015 T3916 T3914 appos IL,interleukin
R2016 T4066 T4065 nummod 1,type
R2017 T4067 T4068 punct (,Th1
R2018 T4068 T4065 appos Th1,type
R2019 T3917 T3918 punct ),-1
R2020 T4069 T4068 punct ),Th1
R2021 T4070 T4065 conj cytokines,type
R2022 T4071 T4070 prep in,cytokines
R2023 T3918 T3919 nsubj -1,suggest
R2024 T4072 T4073 compound RA,[
R2025 T4073 T4071 pobj [,in
R2026 T3919 T3911 conj suggest,α
R2027 T4074 T4075 nummod 4,]
R2028 T4075 T4082 nsubj ],needs
R2029 T4076 T4075 punct ",",]
R2030 T4077 T4078 det the,role
R2031 T4078 T4075 appos role,]
R2032 T4079 T4078 prep of,role
R2033 T3920 T3928 mark that,been
R2034 T4080 T4081 compound T,cells
R2035 T4081 T4079 pobj cells,of
R2036 T4082 T4043 conj needs,demonstrated
R2037 T3921 T3922 det the,blockade
R2038 T4083 T4085 aux to,elucidated
R2039 T4084 T4085 auxpass be,elucidated
R2040 T4085 T4082 xcomp elucidated,needs
R2041 T3922 T3928 nsubj blockade,been
R2042 T4086 T4085 prep in,elucidated
R2043 T4087 T4088 amod different,aspects
R2044 T4088 T4086 pobj aspects,in
R2045 T3923 T3922 prep of,blockade
R2046 T4089 T4082 punct .,needs
R2047 T4090 T4091 nsubj IL-17,is
R2048 T3924 T3926 amod key,cytokines
R2049 T4091 T4091 ROOT is,is
R2050 T4092 T4091 attr one,is
R2051 T4093 T4092 prep of,one
R2052 T3925 T3926 amod inflammatory,cytokines
R2053 T4094 T4096 det the,cytokines
R2054 T4095 T4096 amod inflammatory,cytokines
R2055 T4096 T4093 pobj cytokines,of
R2056 T3926 T3923 pobj cytokines,of
R2057 T4097 T4092 acl secreted,one
R2058 T4098 T4099 advmod mainly,by
R2059 T4099 T4097 agent by,secreted
R2060 T3927 T3928 aux has,been
R2061 T4100 T4102 amod activated,cells
R2062 T4101 T4102 compound T,cells
R2063 T4102 T4099 pobj cells,by
R2064 T3928 T3919 ccomp been,suggest
R2065 T4103 T4102 punct ",",cells
R2066 T4104 T4106 nsubj which,induce
R2067 T4105 T4106 aux can,induce
R2068 T3929 T3931 det the,issue
R2069 T4106 T4102 relcl induce,cells
R2070 T4107 T4106 dobj IL-6,induce
R2071 T3930 T3931 amod important,issue
R2072 T4108 T4107 cc and,IL-6
R2073 T4109 T4107 conj IL-8,IL-6
R2074 T4110 T4106 prep by,induce
R2075 T3931 T3928 attr issue,been
R2076 T4111 T4110 pobj fibroblasts,by
R2077 T4112 T4114 nmod [,]
R2078 T4113 T4114 nummod 5,]
R2079 T3932 T3931 prep in,issue
R2080 T4114 T4106 npadvmod ],induce
R2081 T3933 T3934 det the,development
R2082 T4115 T4091 punct .,is
R2083 T4116 T4117 det This,cytokine
R2084 T3934 T3932 pobj development,in
R2085 T4117 T4118 nsubj cytokine,is
R2086 T4118 T4143 ccomp is,produced
R2087 T3935 T3934 prep of,development
R2088 T4119 T4118 prep of,is
R2089 T4120 T4119 pobj interest,of
R2090 T4121 T4118 prep for,is
R2091 T3936 T3938 amod new,applications
R2092 T4122 T4124 nummod two,reasons
R2093 T4123 T4124 amod major,reasons
R2094 T4124 T4121 pobj reasons,for
R2095 T3937 T3938 amod therapeutic,applications
R2096 T4125 T4124 punct :,reasons
R2097 T3938 T3935 pobj applications,of
R2098 T4126 T4129 advmod first,to
R2099 T4127 T4129 punct ",",to
R2100 T3939 T3941 amod [,]
R2101 T4128 T4129 advmod similarly,to
R2102 T4129 T4118 prep to,is
R2103 T4130 T4129 pobj TNF-α,to
R2104 T3940 T3941 nummod 2,]
R2105 T4131 T4130 cc and,TNF-α
R2106 T4132 T4130 conj IL-1,TNF-α
R2107 T3941 T3931 conj ],issue
R2108 T4133 T4135 punct ",",has
R2109 T4134 T4135 nsubj IL-17,has
R2110 T4135 T4143 ccomp has,produced
R2111 T3942 T3919 punct .,suggest
R2112 T4136 T4137 amod proinflammatory,properties
R2113 T4137 T4135 dobj properties,has
R2114 T4138 T4143 punct ;,produced
R2115 T3943 T3944 det A,little
R2116 T4139 T4143 advmod second,produced
R2117 T4140 T4143 punct ",",produced
R2118 T4141 T4143 nsubjpass it,produced
R2119 T3944 T3948 npadvmod little,ago
R2120 T3945 T3946 quantmod over,a
R2121 T3946 T3947 nummod a,decade
R2122 T3947 T3948 npadvmod decade,ago
R2123 T4142 T4143 auxpass is,produced
R2124 T4143 T4143 ROOT produced,produced
R2125 T4239 T4237 acomp higher,were
R2126 T4144 T4143 agent by,produced
R2127 T4145 T4146 compound T,cells
R2128 T4146 T4144 pobj cells,by
R2129 T4147 T4149 nmod [,]
R2130 T4148 T4149 nummod 6,]
R2131 T4149 T4146 appos ],cells
R2132 T4150 T4143 punct .,produced
R2133 T4151 T4152 amod Recent,observations
R2134 T4240 T4237 prep in,were
R2135 T4152 T4153 nsubj observations,demonstrated
R2136 T4153 T4153 ROOT demonstrated,demonstrated
R2137 T4154 T4158 mark that,activate
R2138 T4241 T4240 pobj patients,in
R2139 T4155 T4158 nsubj IL-17,activate
R2140 T4242 T4241 prep with,patients
R2141 T4156 T4158 aux can,activate
R2142 T4157 T4158 advmod also,activate
R2143 T4158 T4153 ccomp activate,demonstrated
R2144 T4159 T4161 amod osteoclastic,resorption
R2145 T4243 T4242 pobj RA,with
R2146 T4160 T4161 compound bone,resorption
R2147 T4161 T4158 dobj resorption,activate
R2148 T4162 T4158 prep by,activate
R2149 T4244 T4237 prep than,were
R2150 T4163 T4164 det the,induction
R2151 T4164 T4162 pobj induction,by
R2152 T4165 T4164 prep of,induction
R2153 T4245 T4244 prep in,than
R2154 T4166 T4165 pobj RANKL,of
R2155 T4167 T4169 punct (,activator
R2156 T4168 T4169 compound receptor,activator
R2157 T4246 T4245 pobj patients,in
R2158 T4169 T4166 appos activator,RANKL
R2159 T4170 T4169 prep of,activator
R2160 T4171 T4172 amod nuclear,factor
R2161 T4247 T4246 prep with,patients
R2162 T4172 T4170 pobj factor,of
R2163 T4173 T4177 compound κB,ligand
R2164 T4174 T4177 compound [,ligand
R2165 T4248 T4247 pobj osteoarthritis,with
R2166 T4175 T4177 compound NF-κB,ligand
R2167 T4176 T4177 compound ],ligand
R2168 T4177 T4172 appos ligand,factor
R2169 T4249 T4248 punct (,osteoarthritis
R2170 T4178 T4177 punct ),ligand
R2171 T4179 T4172 punct ",",factor
R2172 T4180 T4182 nsubjpass which,involved
R2173 T4250 T4248 appos OA,osteoarthritis
R2174 T4181 T4182 auxpass is,involved
R2175 T4182 T4172 relcl involved,factor
R2176 T4183 T4182 prep in,involved
R2177 T4251 T4248 punct ),osteoarthritis
R2178 T4184 T4185 amod bony,erosion
R2179 T4185 T4183 pobj erosion,in
R2180 T4252 T4237 punct ",",were
R2181 T4186 T4185 prep in,erosion
R2182 T4187 T4188 compound RA,[
R2183 T4188 T4186 pobj [,in
R2184 T4189 T4190 nummod 7,]
R2185 T4190 T4166 conj ],RANKL
R2186 T4191 T4153 punct .,demonstrated
R2187 T4253 T4237 cc and,were
R2188 T4192 T4194 nsubj It,stimulates
R2189 T4193 T4194 advmod also,stimulates
R2190 T4194 T4194 ROOT stimulates,stimulates
R2191 T4195 T4196 det the,production
R2192 T4254 T4256 nsubjpass it,produced
R2193 T4196 T4194 dobj production,stimulates
R2194 T4197 T4196 prep of,production
R2195 T4198 T4197 pobj IL-6,of
R2196 T4255 T4256 auxpass was,produced
R2197 T4199 T4198 cc and,IL-6
R2198 T4200 T4202 nmod leukemia,factor
R2199 T4201 T4202 amod inhibitory,factor
R2200 T4256 T4237 conj produced,were
R2201 T4202 T4196 conj factor,production
R2202 T4257 T4256 agent by,produced
R2203 T4203 T4196 prep by,production
R2204 T4258 T4261 compound CD4,cells
R2205 T4204 T4203 pobj synoviocytes,by
R2206 T4205 T4194 punct ",",stimulates
R2207 T4259 T4261 compound +,cells
R2208 T4206 T4194 cc and,stimulates
R2209 T4207 T4194 conj of,stimulates
R2210 T4208 T4207 pobj prostaglandin,of
R2211 T4260 T4261 compound T,cells
R2212 T4209 T4208 nummod E2,prostaglandin
R2213 T4210 T4208 cc and,prostaglandin
R2214 T4211 T4212 amod nitric,oxide
R2215 T4261 T4257 pobj cells,by
R2216 T4212 T4208 conj oxide,prostaglandin
R2217 T4213 T4194 prep by,stimulates
R2218 T4262 T4261 prep in,cells
R2219 T4214 T4213 pobj chondrocytes,by
R2220 T4215 T4194 punct ",",stimulates
R2221 T4216 T4194 cc and,stimulates
R2222 T4263 T4267 det the,]
R2223 T4217 T4194 conj has,stimulates
R2224 T4218 T4219 det the,ability
R2225 T4219 T4217 dobj ability,has
R2226 T4264 T4265 compound synovium,[
R2227 T4220 T4221 aux to,differentiate
R2228 T4221 T4219 acl differentiate,ability
R2229 T4222 T4221 cc and,differentiate
R2230 T4265 T4267 compound [,]
R2231 T4223 T4221 conj activate,differentiate
R2232 T4224 T4226 det the,cells
R2233 T4225 T4226 amod dendritic,cells
R2234 T4226 T4223 dobj cells,activate
R2235 T4227 T4229 compound [,]
R2236 T4228 T4229 compound 8-10,]
R2237 T4266 T4267 compound "11,12",]
R2238 T4229 T4226 appos ],cells
R2239 T4230 T4194 punct .,stimulates
R2240 T4231 T4237 nsubj Levels,were
R2241 T4267 T4262 pobj ],in
R2242 T4232 T4231 prep of,Levels
R2243 T4233 T4232 pobj IL-17,of
R2244 T4234 T4231 prep in,Levels
R2245 T4268 T4256 punct .,produced
R2246 T4235 T4236 amod synovial,fluids
R2247 T4236 T4234 pobj fluids,in
R2248 T4237 T4237 ROOT were,were
R2249 T4269 T4271 nsubj IL-15,secreted
R2250 T4238 T4239 advmod significantly,higher
R2251 T4270 T4269 punct ",",IL-15
R2252 T4271 T4271 ROOT secreted,secreted
R2253 T4272 T4271 prep from,secreted
R2254 T4336 T4348 mark Although,documented
R2255 T4273 T4274 amod activated,macrophages
R2256 T4337 T4338 det the,contribution
R2257 T4338 T4348 nsubjpass contribution,documented
R2258 T4274 T4272 pobj macrophages,from
R2259 T4339 T4338 prep of,contribution
R2260 T4340 T4339 pobj IL-17,of
R2261 T4341 T4338 prep in,contribution
R2262 T4275 T4278 punct ",",reported
R2263 T4342 T4343 amod joint,inflammation
R2264 T4343 T4341 pobj inflammation,in
R2265 T4276 T4278 aux has,reported
R2266 T4344 T4343 prep in,inflammation
R2267 T4345 T4344 pobj RA,in
R2268 T4346 T4348 aux has,documented
R2269 T4277 T4278 auxpass been,reported
R2270 T4347 T4348 auxpass been,documented
R2271 T4348 T4364 advcl documented,remains
R2272 T4349 T4348 prep in,documented
R2273 T4278 T4271 conj reported,secreted
R2274 T4350 T4351 amod earlier,studies
R2275 T4351 T4349 pobj studies,in
R2276 T4352 T4354 compound [,]
R2277 T4279 T4280 aux to,be
R2278 T4353 T4354 compound "12,15,16",]
R2279 T4354 T4364 nsubj ],remains
R2280 T4355 T4354 punct ",",]
R2281 T4356 T4360 det the,pathway
R2282 T4357 T4360 amod intracellular,pathway
R2283 T4358 T4360 nmod signal,pathway
R2284 T4280 T4278 xcomp be,reported
R2285 T4359 T4360 compound transduction,pathway
R2286 T4360 T4354 appos pathway,]
R2287 T4281 T4283 det an,trigger
R2288 T4361 T4360 prep for,pathway
R2289 T4282 T4283 amod important,trigger
R2290 T4362 T4363 amod IL-17,production
R2291 T4363 T4361 pobj production,for
R2292 T4283 T4280 attr trigger,be
R2293 T4364 T4364 ROOT remains,remains
R2294 T4365 T4364 acomp uncertain,remains
R2295 T4366 T4364 punct .,remains
R2296 T4284 T4283 prep of,trigger
R2297 T4367 T4367 ROOT In,In
R2298 T4368 T4370 det the,study
R2299 T4369 T4370 amod present,study
R2300 T4285 T4286 amod IL-17,production
R2301 T4370 T4367 pobj study,In
R2302 T4286 T4284 pobj production,of
R2303 T4371 T4372 nsubj we,used
R2304 T4372 T4370 relcl used,study
R2305 T4373 T4374 amod various,stimuli
R2306 T4287 T4286 prep in,production
R2307 T4374 T4372 dobj stimuli,used
R2308 T4375 T4376 aux to,investigate
R2309 T4376 T4372 xcomp investigate,used
R2310 T4377 T4378 amod IL-17,production
R2311 T4288 T4292 compound RA,cells
R2312 T4378 T4376 dobj production,investigate
R2313 T4379 T4378 prep in,production
R2314 T4289 T4290 compound peripheral,blood
R2315 T4380 T4379 pobj PBMC,in
R2316 T4381 T4380 prep of,PBMC
R2317 T4382 T4381 pobj patients,of
R2318 T4290 T4291 compound blood,mononuclear
R2319 T4383 T4382 prep with,patients
R2320 T4384 T4383 pobj RA,with
R2321 T4385 T4384 cc and,RA
R2322 T4291 T4292 compound mononuclear,cells
R2323 T4386 T4389 poss its,pathway
R2324 T4387 T4389 amod signaling,pathway
R2325 T4292 T4287 pobj cells,in
R2326 T4388 T4389 compound transduction,pathway
R2327 T4389 T4384 conj pathway,RA
R2328 T4390 T4367 punct .,In
R2329 T4293 T4286 punct (,production
R2330 T4391 T4392 nsubj We,found
R2331 T4392 T4392 ROOT found,found
R2332 T4393 T4404 mark that,/
R2333 T4394 T4397 det the,pathway
R2334 T4395 T4397 amod intracellular,pathway
R2335 T4396 T4397 amod signaling,pathway
R2336 T4294 T4283 appos PBMC,trigger
R2337 T4397 T4404 nsubj pathway,/
R2338 T4398 T4397 acl involving,pathway
R2339 T4399 T4398 dobj phosphoinositide,involving
R2340 T4400 T4403 nmod 3-kinase,)
R2341 T4295 T4283 punct ),trigger
R2342 T4401 T4402 punct (,PI3K
R2343 T4402 T4400 appos PI3K,3-kinase
R2344 T4403 T4397 punct ),pathway
R2345 T4296 T4278 agent by,reported
R2346 T4404 T4392 ccomp /,found
R2347 T4405 T4404 dobj Akt,/
R2348 T4297 T4296 pobj cyclosporine,by
R2349 T4406 T4405 cc and,Akt
R2350 T4407 T4405 conj NF-κB,Akt
R2351 T4298 T4297 cc and,cyclosporine
R2352 T4408 T4410 aux might,involved
R2353 T4409 T4410 auxpass be,involved
R2354 T4410 T4392 conj involved,found
R2355 T4411 T4410 prep in,involved
R2356 T4299 T4301 amod steroid,pathways
R2357 T4412 T4413 det the,overproduction
R2358 T4413 T4411 pobj overproduction,in
R2359 T4414 T4413 prep of,overproduction
R2360 T4300 T4301 amod sensitive,pathways
R2361 T4415 T4419 det the,IL-17
R2362 T4416 T4419 amod key,IL-17
R2363 T4301 T4297 conj pathways,cyclosporine
R2364 T4417 T4418 amod inflammatory,cytokine
R2365 T4418 T4419 compound cytokine,IL-17
R2366 T4419 T4414 pobj IL-17,of
R2367 T4420 T4419 prep in,IL-17
R2368 T4302 T4304 nmod [,]
R2369 T4421 T4420 pobj RA,in
R2370 T4422 T4392 punct .,found
R2371 T4303 T4304 nummod 13,]
R2372 T4423 T4424 det These,results
R2373 T4424 T4426 nsubj results,provide
R2374 T4425 T4426 aux might,provide
R2375 T4304 T4278 conj ],reported
R2376 T4426 T4426 ROOT provide,provide
R2377 T4427 T4428 amod new,insights
R2378 T4428 T4426 dobj insights,provide
R2379 T4305 T4278 punct .,reported
R2380 T4429 T4426 prep into,provide
R2381 T4430 T4431 det the,pathogenesis
R2382 T4431 T4429 pobj pathogenesis,into
R2383 T4432 T4431 prep of,pathogenesis
R2384 T4306 T4312 advmod Recently,showed
R2385 T4307 T4312 punct ",",showed
R2386 T4433 T4432 pobj RA,of
R2387 T4434 T4431 cc and,pathogenesis
R2388 T4435 T4436 amod future,directions
R2389 T4308 T4312 nsubj Happel,showed
R2390 T4436 T4431 conj directions,pathogenesis
R2391 T4437 T4436 prep for,directions
R2392 T4438 T4440 amod new,strategies
R2393 T4309 T4308 cc and,Happel
R2394 T4439 T4440 amod therapeutic,strategies
R2395 T4440 T4437 pobj strategies,for
R2396 T4310 T4308 conj colleagues,Happel
R2397 T4441 T4440 prep in,strategies
R2398 T4311 T4312 advmod also,showed
R2399 T4442 T4441 pobj RA,in
R2400 T4443 T4426 punct .,provide
R2401 T4312 T4312 ROOT showed,showed
R2402 T4313 T4316 mark that,be
R2403 T4314 T4316 nsubj IL-23,be
R2404 T4315 T4316 aux could,be
R2405 T4316 T4312 ccomp be,showed
R2406 T4317 T4319 det an,trigger
R2407 T4318 T4319 amod efficient,trigger
R2408 T4319 T4316 attr trigger,be
R2409 T4320 T4319 prep of,trigger
R2410 T4321 T4322 amod IL-17,production
R2412 T4322 T4320 pobj production,of
R2414 T4323 T4319 prep from,trigger
R2416 T4324 T4326 preconj both,+
R2419 T4325 T4326 nummod CD4,+
R2422 T4326 T4323 pobj +,from
R2423 T4327 T4326 cc and,+
R2424 T4328 T4331 nummod CD8,cells
R2426 T4329 T4331 nummod +,cells
R2428 T4330 T4331 compound T,cells
R2430 T4331 T4326 conj cells,+
R2436 T4332 T4334 nmod [,]
R2437 T4333 T4334 nummod 14,]
R2440 T4334 T4331 appos ],cells
R2443 T4335 T4312 punct .,showed
R2640 T5038 T5042 nsubjpass Patients,obtained
R2641 T5039 T5040 amod Informed,consent
R2642 T5040 T5042 nsubjpass consent,obtained
R2643 T5041 T5042 auxpass was,obtained
R2644 T5042 T5042 ROOT obtained,obtained
R2645 T5043 T5042 prep from,obtained
R2646 T5044 T5045 nummod 24,patients
R2647 T5045 T5043 pobj patients,from
R2648 T5046 T5045 punct (,patients
R2649 T5047 T5048 nummod 5,men
R2650 T5048 T5045 appos men,patients
R2651 T5049 T5048 cc and,men
R2652 T5050 T5051 nummod 19,women
R2653 T5051 T5048 conj women,men
R2654 T5052 T5045 punct ),patients
R2655 T5053 T5042 prep with,obtained
R2656 T5054 T5053 pobj RA,with
R2657 T5055 T5056 nsubj who,fulfilled
R2658 T5056 T5042 conj fulfilled,obtained
R2659 T5057 T5060 det the,criteria
R2660 T5058 T5060 nummod 1987,criteria
R2661 T5059 T5060 amod revised,criteria
R2662 T5060 T5056 dobj criteria,fulfilled
R2663 T5061 T5060 prep of,criteria
R2664 T5062 T5064 det the,College
R2665 T5063 T5064 compound American,College
R2666 T5064 T5061 pobj College,of
R2667 T5065 T5064 prep of,College
R2668 T5066 T5065 pobj Rheumatology,of
R2669 T5067 T5064 punct (,College
R2670 T5068 T5072 advmod formerly,Association
R2671 T5069 T5072 det the,Association
R2672 T5070 T5072 compound American,Association
R2673 T5071 T5072 compound Rheumatism,Association
R2674 T5072 T5064 appos Association,College
R2675 T5073 T5064 punct ),College
R2676 T5074 T5076 nmod [,]
R2677 T5075 T5076 nummod 17,]
R2678 T5076 T5060 appos ],criteria
R2679 T5077 T5042 punct .,obtained
R2680 T5078 T5079 det The,age
R2681 T5079 T5085 nsubj age,was
R2682 T5080 T5079 prep of,age
R2683 T5081 T5082 det the,patients
R2684 T5082 T5080 pobj patients,of
R2685 T5083 T5082 prep with,patients
R2686 T5084 T5083 pobj RA,with
R2687 T5085 T5085 ROOT was,was
R2688 T5086 T5087 nummod 50,±
R2689 T5087 T5085 attr ±,was
R2690 T5088 T5087 nummod 8,±
R2691 T5089 T5092 punct (,SEM
R2692 T5090 T5092 amod mean,SEM
R2693 T5091 T5092 compound ±,SEM
R2694 T5092 T5087 appos SEM,±
R2695 T5093 T5092 punct ),SEM
R2696 T5094 T5087 appos years,±
R2697 T5095 T5096 punct (,range
R2698 T5096 T5087 appos range,±
R2699 T5097 T5096 nummod 23,range
R2700 T5098 T5099 nummod 71,years
R2701 T5099 T5096 appos years,range
R2702 T5100 T5096 punct ),range
R2703 T5101 T5087 punct .,±
R2704 T5102 T5103 det All,medications
R2705 T5103 T5105 nsubjpass medications,stopped
R2706 T5104 T5105 auxpass were,stopped
R2707 T5105 T5105 ROOT stopped,stopped
R2708 T5106 T5107 nummod 48,hours
R2709 T5107 T5108 npadvmod hours,before
R2710 T5108 T5105 prep before,stopped
R2711 T5109 T5108 pobj entry,before
R2712 T5110 T5109 prep to,entry
R2713 T5111 T5112 det the,study
R2714 T5112 T5110 pobj study,to
R2715 T5113 T5105 punct .,stopped
R2716 T5114 T5116 nsubjpass Comparisons,made
R2717 T5115 T5116 auxpass were,made
R2718 T5116 T5116 ROOT made,made
R2719 T5117 T5116 prep with,made
R2720 T5118 T5119 nummod 14,patients
R2721 T5119 T5117 pobj patients,with
R2722 T5120 T5119 prep with,patients
R2723 T5121 T5120 pobj OA,with
R2724 T5122 T5121 punct (,OA
R2725 T5123 T5124 nummod 3,men
R2726 T5124 T5121 appos men,OA
R2727 T5125 T5124 cc and,men
R2728 T5126 T5127 nummod 11,women
R2729 T5127 T5124 conj women,men
R2730 T5128 T5121 punct ),OA
R2731 T5129 T5120 cc and,with
R2732 T5130 T5120 conj with,with
R2733 T5131 T5133 nummod 14,controls
R2734 T5132 T5133 amod healthy,controls
R2735 T5133 T5130 pobj controls,with
R2736 T5134 T5133 punct (,controls
R2737 T5135 T5136 nummod 3,men
R2738 T5136 T5133 appos men,controls
R2739 T5137 T5136 cc and,men
R2740 T5138 T5139 nummod 11,women
R2741 T5139 T5136 conj women,men
R2742 T5140 T5133 punct ),controls
R2743 T5141 T5142 nsubj who,had
R2744 T5142 T5133 relcl had,controls
R2745 T5143 T5145 det no,diseases
R2746 T5144 T5145 amod rheumatic,diseases
R2747 T5145 T5142 dobj diseases,had
R2748 T5146 T5116 punct .,made
R2749 T5147 T5149 det The,ages
R2750 T5148 T5149 amod mean,ages
R2751 T5149 T5159 nsubj ages,were
R2752 T5150 T5149 prep of,ages
R2753 T5151 T5152 det the,patients
R2754 T5152 T5150 pobj patients,of
R2755 T5153 T5152 prep with,patients
R2756 T5154 T5153 pobj OA,with
R2757 T5155 T5154 cc and,OA
R2758 T5156 T5158 det the,controls
R2759 T5157 T5158 amod healthy,controls
R2760 T5158 T5154 conj controls,OA
R2761 T5159 T5159 ROOT were,were
R2762 T5160 T5161 nummod 50,±
R2763 T5161 T5159 attr ±,were
R2764 T5162 T5163 nummod 8,years
R2765 T5163 T5161 appos years,±
R2766 T5164 T5165 punct (,range
R2767 T5165 T5163 parataxis range,years
R2768 T5166 T5165 nummod 34,range
R2769 T5167 T5168 nummod 68,years
R2770 T5168 T5165 appos years,range
R2771 T5169 T5165 punct ),range
R2772 T5170 T5163 cc and,years
R2773 T5171 T5172 nummod 30,±
R2774 T5172 T5163 conj ±,years
R2775 T5173 T5174 nummod 6,years
R2776 T5174 T5172 appos years,±
R2777 T5175 T5176 punct (,range
R2778 T5176 T5174 parataxis range,years
R2779 T5177 T5176 nummod 24,range
R2780 T5178 T5179 nummod 57,years
R2781 T5179 T5176 appos years,range
R2782 T5180 T5176 punct ),range
R2783 T5181 T5159 punct .,were
R2784 T5182 T5183 amod Informed,consent
R2785 T5183 T5185 nsubjpass consent,obtained
R2786 T5184 T5185 auxpass was,obtained
R2787 T5185 T5185 ROOT obtained,obtained
R2788 T5186 T5185 punct ",",obtained
R2789 T5187 T5185 cc and,obtained
R2790 T5188 T5189 det the,protocol
R2791 T5189 T5191 nsubjpass protocol,approved
R2792 T5190 T5191 auxpass was,approved
R2793 T5191 T5185 conj approved,obtained
R2794 T5192 T5191 agent by,approved
R2795 T5193 T5195 det the,University
R2796 T5194 T5195 compound Catholic,University
R2797 T5195 T5201 nmod University,Committee
R2798 T5196 T5195 prep of,University
R2799 T5197 T5196 pobj Korea,of
R2800 T5198 T5200 compound Human,Ethics
R2801 T5199 T5200 compound Research,Ethics
R2802 T5200 T5201 compound Ethics,Committee
R2803 T5201 T5192 pobj Committee,by
R2804 T5202 T5191 punct .,approved
R2971 T5665 T5667 compound Reagents,IL-17
R2972 T5666 T5667 compound Recombinant,IL-17
R2973 T5667 T5695 nsubjpass IL-17,purchased
R2974 T5668 T5667 punct ",",IL-17
R2975 T5669 T5667 conj IL-18,IL-17
R2976 T5670 T5669 punct ",",IL-18
R2977 T5671 T5669 conj IL-15,IL-18
R2978 T5672 T5671 punct ",",IL-15
R2979 T5673 T5675 nmod monocyte,protein-1
R2980 T5674 T5675 compound chemoattractant,protein-1
R2981 T5675 T5671 appos protein-1,IL-15
R2982 T5676 T5677 punct (,MCP-1
R2983 T5677 T5675 appos MCP-1,protein-1
R2984 T5678 T5677 punct ),MCP-1
R2985 T5679 T5671 punct ",",IL-15
R2986 T5680 T5682 nmod macrophage,protein
R2987 T5681 T5682 amod inflammatory,protein
R2988 T5682 T5667 appos protein,IL-17
R2989 T5683 T5684 punct (,MIP
R2990 T5684 T5682 appos MIP,protein
R2991 T5685 T5684 punct ),MIP
R2992 T5686 T5687 nummod -1,α
R2993 T5687 T5667 appos α,IL-17
R2994 T5688 T5687 punct ",",α
R2995 T5689 T5687 conj MIP-1β,α
R2996 T5690 T5689 punct ",",MIP-1β
R2997 T5691 T5689 conj IL-6,MIP-1β
R2998 T5692 T5691 cc and,IL-6
R2999 T5693 T5691 conj IL-8,IL-6
R3000 T5694 T5695 auxpass were,purchased
R3001 T5695 T5695 ROOT purchased,purchased
R3002 T5696 T5695 prep from,purchased
R3003 T5697 T5700 nmod R,systems
R3004 T5698 T5697 cc &,R
R3005 T5699 T5697 conj D,R
R3006 T5700 T5696 pobj systems,from
R3007 T5701 T5700 punct (,systems
R3008 T5702 T5700 appos Minneapolis,systems
R3009 T5703 T5702 punct ",",Minneapolis
R3010 T5704 T5702 conj MN,Minneapolis
R3011 T5705 T5704 punct ",",MN
R3012 T5706 T5704 npadvmod USA,MN
R3013 T5707 T5704 punct ),MN
R3014 T5708 T5695 punct .,purchased
R3015 T5709 T5712 amod Recombinant,factor
R3016 T5710 T5712 amod transforming,factor
R3017 T5711 T5712 compound growth,factor
R3018 T5712 T5719 nsubjpass factor,purchased
R3019 T5713 T5714 punct (,TGF
R3020 T5714 T5712 appos TGF,factor
R3021 T5715 T5714 punct ),TGF
R3022 T5716 T5717 punct -,β
R3023 T5717 T5712 appos β,factor
R3024 T5718 T5719 auxpass was,purchased
R3025 T5719 T5719 ROOT purchased,purchased
R3026 T5720 T5719 prep from,purchased
R3027 T5721 T5720 pobj Peprotech,from
R3028 T5722 T5721 punct (,Peprotech
R3029 T5723 T5721 appos London,Peprotech
R3030 T5724 T5723 punct ",",London
R3031 T5725 T5723 appos UK,London
R3032 T5726 T5723 punct ),London
R3033 T5727 T5719 punct .,purchased
R3034 T5728 T5729 amod Recombinant,TNF-α
R3035 T5729 T5733 nsubjpass TNF-α,purchased
R3036 T5730 T5729 cc and,TNF-α
R3037 T5731 T5729 conj IL-1,TNF-α
R3038 T5732 T5733 auxpass were,purchased
R3039 T5733 T5733 ROOT purchased,purchased
R3040 T5734 T5733 prep from,purchased
R3041 T5735 T5736 compound Endogen,Inc.
R3042 T5736 T5734 pobj Inc.,from
R3043 T5737 T5736 punct (,Inc.
R3044 T5738 T5736 npadvmod Cambridge,Inc.
R3045 T5739 T5738 punct ",",Cambridge
R3046 T5740 T5738 conj MA,Cambridge
R3047 T5741 T5740 punct ",",MA
R3048 T5742 T5740 conj USA,MA
R3049 T5743 T5740 punct ),MA
R3050 T5744 T5733 punct .,purchased
R3051 T5745 T5746 compound Cyclosporin,A
R3052 T5746 T5748 nsubjpass A,provided
R3053 T5747 T5748 auxpass was,provided
R3054 T5748 T5748 ROOT provided,provided
R3055 T5749 T5748 agent by,provided
R3056 T5750 T5751 compound Sandos,Ltd.
R3057 T5751 T5749 pobj Ltd.,by
R3058 T5752 T5751 punct (,Ltd.
R3059 T5753 T5751 npadvmod Basel,Ltd.
R3060 T5754 T5753 punct ",",Basel
R3061 T5755 T5753 appos Switzerland,Basel
R3062 T5756 T5753 punct ),Basel
R3063 T5757 T5748 punct .,provided
R3064 T5758 T5776 nsubjpass Phytohemagglutinin,obtained
R3065 T5759 T5760 punct (,PHA
R3066 T5760 T5758 appos PHA,Phytohemagglutinin
R3067 T5761 T5760 punct ),PHA
R3068 T5762 T5758 punct ",",Phytohemagglutinin
R3069 T5763 T5764 amod pyrrolidine,dithiocarbamate
R3070 T5764 T5758 appos dithiocarbamate,Phytohemagglutinin
R3071 T5765 T5766 punct (,PDTC
R3072 T5766 T5764 appos PDTC,dithiocarbamate
R3073 T5767 T5766 punct ),PDTC
R3074 T5768 T5764 punct ",",dithiocarbamate
R3075 T5769 T5764 conj rapamycin,dithiocarbamate
R3076 T5770 T5769 punct ",",rapamycin
R3077 T5771 T5769 conj dexamethasone,rapamycin
R3078 T5772 T5771 cc and,dexamethasone
R3079 T5773 T5771 conj curcumin,dexamethasone
R3080 T5774 T5776 auxpass were,obtained
R3081 T5775 T5776 dep all,obtained
R3082 T5776 T5776 ROOT obtained,obtained
R3083 T5777 T5776 prep from,obtained
R3084 T5778 T5781 det the,Co.
R3085 T5779 T5781 compound Sigma,Co.
R3086 T5780 T5781 compound Chemical,Co.
R3087 T5781 T5777 pobj Co.,from
R3088 T5782 T5781 punct (,Co.
R3089 T5783 T5784 compound St,Louis
R3090 T5784 T5781 appos Louis,Co.
R3091 T5785 T5781 punct ",",Co.
R3092 T5786 T5781 conj MA,Co.
R3093 T5787 T5786 punct ",",MA
R3094 T5788 T5786 conj USA,MA
R3095 T5789 T5776 punct ),obtained
R3096 T5790 T5776 punct .,obtained
R3097 T5791 T5793 amod Anti-CD3,antibody
R3098 T5792 T5793 amod monoclonal,antibody
R3099 T5793 T5799 nsubjpass antibody,obtained
R3100 T5794 T5793 cc and,antibody
R3101 T5795 T5797 amod anti-CD28,antibody
R3102 T5796 T5797 amod monoclonal,antibody
R3103 T5797 T5793 conj antibody,antibody
R3104 T5798 T5799 auxpass were,obtained
R3105 T5799 T5799 ROOT obtained,obtained
R3106 T5800 T5799 prep from,obtained
R3107 T5801 T5802 compound BD,Biosciences
R3108 T5802 T5800 pobj Biosciences,from
R3109 T5803 T5802 punct (,Biosciences
R3110 T5804 T5805 compound San,Diego
R3111 T5805 T5802 npadvmod Diego,Biosciences
R3112 T5806 T5805 punct ",",Diego
R3113 T5807 T5805 conj CA,Diego
R3114 T5808 T5807 punct ",",CA
R3115 T5809 T5807 conj USA,CA
R3116 T5810 T5802 punct ),Biosciences
R3117 T5811 T5799 punct .,obtained
R3118 T5812 T5822 nsubjpass LY294002,obtained
R3119 T5813 T5812 punct ",",LY294002
R3120 T5814 T5822 nsubjpass SB203580,obtained
R3121 T5815 T5814 punct ",",SB203580
R3122 T5816 T5814 conj FK506,SB203580
R3123 T5817 T5816 punct ",",FK506
R3124 T5818 T5816 conj wortmannin,FK506
R3125 T5819 T5818 cc and,wortmannin
R3126 T5820 T5822 nsubjpass PD98059,obtained
R3127 T5821 T5822 auxpass were,obtained
R3128 T5822 T5822 ROOT obtained,obtained
R3129 T5823 T5822 prep from,obtained
R3130 T5824 T5823 pobj Calbiochem,from
R3131 T5825 T5826 punct (,Schwalbach
R3132 T5826 T5824 appos Schwalbach,Calbiochem
R3133 T5827 T5826 punct ",",Schwalbach
R3134 T5828 T5826 appos Germany,Schwalbach
R3135 T5829 T5826 punct ),Schwalbach
R3136 T5830 T5822 punct .,obtained
R3328 T6294 T6308 nsubjpass Production,prepared
R3329 T6295 T6294 prep of,Production
R3330 T6296 T6295 pobj IL-17,of
R3331 T6297 T6294 prep by,Production
R3332 T6298 T6301 compound T,activation
R3333 T6299 T6300 compound cell,receptor
R3334 T6300 T6301 compound receptor,activation
R3335 T6301 T6297 pobj activation,by
R3336 T6302 T6301 punct ",",activation
R3337 T6303 T6301 conj cytokines,activation
R3338 T6304 T6303 cc or,cytokines
R3339 T6305 T6306 compound chemokines,PBMC
R3340 T6306 T6303 conj PBMC,cytokines
R3341 T6307 T6308 auxpass were,prepared
R3342 T6308 T6308 ROOT prepared,prepared
R3343 T6309 T6308 prep from,prepared
R3344 T6310 T6311 amod heparinized,blood
R3345 T6311 T6309 pobj blood,from
R3346 T6312 T6308 agent by,prepared
R3347 T6313 T6318 nmod Ficoll-Hypaque,centrifugation
R3348 T6314 T6315 punct (,SG1077
R3349 T6315 T6313 appos SG1077,Ficoll-Hypaque
R3350 T6316 T6318 punct ),centrifugation
R3351 T6317 T6318 amod density-gradient,centrifugation
R3352 T6318 T6312 pobj centrifugation,by
R3353 T6319 T6308 punct .,prepared
R3354 T6320 T6321 compound Cell,cultures
R3355 T6321 T6323 nsubjpass cultures,performed
R3356 T6322 T6323 auxpass were,performed
R3357 T6323 T6323 ROOT performed,performed
R3358 T6324 T6325 mark as,described
R3359 T6325 T6323 advcl described,performed
R3360 T6326 T6329 advmod previously,]
R3361 T6327 T6329 nmod [,]
R3362 T6328 T6329 nummod 18,]
R3363 T6329 T6325 dobj ],described
R3364 T6330 T6323 punct .,performed
R3365 T6331 T6338 prep In,adjusted
R3366 T6332 T6331 pobj brief,In
R3367 T6333 T6338 punct ",",adjusted
R3368 T6334 T6336 det the,suspensions
R3369 T6335 T6336 compound cell,suspensions
R3370 T6336 T6338 nsubjpass suspensions,adjusted
R3371 T6337 T6338 auxpass were,adjusted
R3372 T6338 T6338 ROOT adjusted,adjusted
R3373 T6339 T6348 prep to,supplemented
R3374 T6340 T6341 det a,concentration
R3375 T6341 T6339 pobj concentration,to
R3376 T6342 T6341 prep of,concentration
R3377 T6343 T6342 pobj 106/ml,of
R3378 T6344 T6341 prep in,concentration
R3379 T6345 T6348 nsubj RPMI,supplemented
R3380 T6346 T6347 nummod 1640,medium
R3381 T6347 T6348 nsubj medium,supplemented
R3382 T6348 T6338 xcomp supplemented,adjusted
R3383 T6349 T6348 prep with,supplemented
R3384 T6350 T6351 nummod 10,%
R3385 T6351 T6354 compound %,serum
R3386 T6352 T6353 amod fetal,calf
R3387 T6353 T6354 compound calf,serum
R3388 T6354 T6349 pobj serum,with
R3389 T6355 T6354 punct ",",serum
R3390 T6356 T6358 nummod 100,penicillin
R3391 T6357 T6358 compound U/ml,penicillin
R3392 T6358 T6354 conj penicillin,serum
R3393 T6359 T6358 punct ",",penicillin
R3394 T6360 T6362 nummod 100,streptomycin
R3395 T6361 T6362 compound mg/ml,streptomycin
R3396 T6362 T6358 conj streptomycin,penicillin
R3397 T6363 T6362 cc and,streptomycin
R3398 T6364 T6366 nummod 2,L-glutamine
R3399 T6365 T6366 compound mM,L-glutamine
R3400 T6366 T6362 conj L-glutamine,streptomycin
R3401 T6367 T6338 punct .,adjusted
R3402 T6368 T6369 compound Cell,suspension
R3403 T6369 T6375 nsubjpass suspension,dispensed
R3404 T6370 T6372 punct (,ml
R3405 T6371 T6372 nummod 1,ml
R3406 T6372 T6369 appos ml,suspension
R3407 T6373 T6372 punct ),ml
R3408 T6374 T6375 auxpass was,dispensed
R3409 T6375 T6375 ROOT dispensed,dispensed
R3410 T6376 T6375 prep into,dispensed
R3411 T6377 T6379 amod 24-well,plates
R3412 T6378 T6379 amod multi-well,plates
R3413 T6379 T6376 pobj plates,into
R3414 T6380 T6379 punct (,plates
R3415 T6381 T6381 ROOT Nunc,Nunc
R3416 T6382 T6381 punct ",",Nunc
R3417 T6383 T6381 conj Roskilde,Nunc
R3418 T6384 T6383 punct ",",Roskilde
R3419 T6385 T6383 npadvmod Denmark,Roskilde
R3420 T6386 T6383 punct ),Roskilde
R3421 T6387 T6381 punct ",",Nunc
R3422 T6388 T6375 cc and,dispensed
R3423 T6389 T6375 conj incubated,dispensed
R3424 T6390 T6389 prep for,incubated
R3425 T6391 T6392 nummod 24,hours
R3426 T6392 T6390 pobj hours,for
R3427 T6393 T6389 prep at,incubated
R3428 T6394 T6395 nummod 37,°
R3429 T6395 T6393 pobj °,at
R3430 T6396 T6389 conj C,incubated
R3431 T6397 T6389 prep in,incubated
R3432 T6398 T6399 nummod 5,%
R3433 T6399 T6397 pobj %,in
R3434 T6400 T6399 nummod CO2,%
R3435 T6401 T6375 punct .,dispensed
R3436 T6402 T6415 advmod Subsequently,added
R3437 T6403 T6415 punct ",",added
R3438 T6404 T6405 amod various,concentrations
R3439 T6405 T6415 nsubjpass concentrations,added
R3440 T6406 T6405 prep of,concentrations
R3441 T6407 T6408 compound cyclosporin,A
R3442 T6408 T6406 pobj A,of
R3443 T6409 T6408 punct (,A
R3444 T6410 T6408 appos 10,A
R3445 T6411 T6412 nummod 500,ng/ml
R3446 T6412 T6410 appos ng/ml,10
R3447 T6413 T6408 punct ),A
R3448 T6414 T6415 auxpass were,added
R3449 T6415 T6415 ROOT added,added
R3450 T6416 T6415 prep to,added
R3451 T6417 T6418 det the,medium
R3452 T6418 T6416 pobj medium,to
R3453 T6419 T6418 cc and,medium
R3454 T6420 T6418 conj cells,medium
R3455 T6421 T6422 auxpass were,incubated
R3456 T6422 T6422 ROOT incubated,incubated
R3457 T6423 T6422 prep for,incubated
R3458 T6424 T6425 nummod 24,hours
R3459 T6425 T6423 pobj hours,for
R3460 T6426 T6422 punct .,incubated
R3461 T6427 T6431 aux To,added
R3462 T6428 T6429 det each,well
R3463 T6429 T6431 nsubjpass well,added
R3464 T6430 T6431 auxpass was,added
R3465 T6431 T6431 ROOT added,added
R3466 T6432 T6431 dobj FK506,added
R3467 T6433 T6432 punct ",",FK506
R3468 T6434 T6432 appos rapamycin,FK506
R3469 T6435 T6434 punct ",",rapamycin
R3470 T6436 T6434 conj curcumin,rapamycin
R3471 T6437 T6436 punct ",",curcumin
R3472 T6438 T6436 conj PDTC,curcumin
R3473 T6439 T6438 punct ",",PDTC
R3474 T6440 T6438 conj LY294002,PDTC
R3475 T6441 T6440 punct ",",LY294002
R3476 T6442 T6440 conj SB203580,LY294002
R3477 T6443 T6442 punct ",",SB203580
R3478 T6444 T6442 conj PD98059,SB203580
R3479 T6445 T6444 punct ",",PD98059
R3480 T6446 T6444 conj dexamethasone,PD98059
R3481 T6447 T6446 cc or,dexamethasone
R3482 T6448 T6446 conj wortmannin,dexamethasone
R3483 T6449 T6431 punct .,added
R3484 T6450 T6464 prep After,collected
R3485 T6451 T6450 pobj incubation,After
R3486 T6452 T6451 prep for,incubation
R3487 T6453 T6454 nummod 24,hours
R3488 T6454 T6452 pobj hours,for
R3489 T6455 T6458 punct (,stated
R3490 T6456 T6458 mark unless,stated
R3491 T6457 T6458 advmod otherwise,stated
R3492 T6458 T6464 advcl stated,collected
R3493 T6459 T6458 punct ),stated
R3494 T6460 T6464 punct ",",collected
R3495 T6461 T6462 amod cell-free,media
R3496 T6462 T6464 nsubjpass media,collected
R3497 T6463 T6464 auxpass were,collected
R3498 T6464 T6464 ROOT collected,collected
R3499 T6465 T6464 cc and,collected
R3500 T6466 T6464 conj stored,collected
R3501 T6467 T6466 prep at,stored
R3502 T6468 T6469 nummod -20,°
R3503 T6469 T6470 nummod °,C
R3504 T6470 T6467 pobj C,at
R3505 T6471 T6472 mark until,assayed
R3506 T6472 T6466 advcl assayed,stored
R3507 T6473 T6464 punct .,collected
R3508 T6474 T6475 det All,cultures
R3509 T6475 T6477 nsubjpass cultures,set
R3510 T6476 T6477 auxpass were,set
R3511 T6477 T6477 ROOT set,set
R3512 T6478 T6477 prt up,set
R3513 T6479 T6477 prep in,set
R3514 T6480 T6479 pobj triplicate,in
R3515 T6481 T6477 punct ",",set
R3516 T6482 T6477 cc and,set
R3517 T6483 T6485 nsubjpass results,expressed
R3518 T6484 T6485 auxpass are,expressed
R3519 T6485 T6477 conj expressed,set
R3520 T6486 T6485 prep as,expressed
R3521 T6487 T6486 pobj means,as
R3522 T6488 T6489 compound ±,SEM
R3523 T6489 T6487 dobj SEM,means
R3524 T6490 T6485 punct .,expressed
R3721 T6978 T6981 nummod CD4,isolation
R3722 T6979 T6981 nummod +,isolation
R3723 T6980 T6981 compound T-cell,isolation
R3724 T6981 T6987 nsubjpass isolation,used
R3725 T6982 T6981 prep by,isolation
R3726 T6983 T6982 pobj MACS,by
R3727 T6984 T6985 amod Anti-CD4,microbeads
R3728 T6985 T6987 nsubjpass microbeads,used
R3729 T6986 T6987 auxpass were,used
R3730 T6987 T6987 ROOT used,used
R3731 T6988 T6990 advmod essentially,recommended
R3732 T6989 T6990 mark as,recommended
R3733 T6990 T6987 advcl recommended,used
R3734 T6991 T6990 agent by,recommended
R3735 T6992 T6993 det the,manufacturer
R3736 T6993 T6991 pobj manufacturer,by
R3737 T6994 T6993 punct (,manufacturer
R3738 T6995 T6993 appos Miltenyi,manufacturer
R3739 T6996 T6993 punct ),manufacturer
R3740 T6997 T6999 nmod [,]
R3741 T6998 T6999 nummod 19,]
R3742 T6999 T6990 dobj ],recommended
R3743 T7000 T6987 punct .,used
R3744 T7001 T7003 nsubjpass PBMC,resuspended
R3745 T7002 T7003 auxpass were,resuspended
R3746 T7003 T7003 ROOT resuspended,resuspended
R3747 T7004 T7003 prep in,resuspended
R3748 T7005 T7006 nummod 80,μl
R3749 T7006 T7004 pobj μl,in
R3750 T7007 T7006 prep of,μl
R3751 T7008 T7007 pobj FBS,of
R3752 T7009 T7003 advcl staining,resuspended
R3753 T7010 T7009 dobj buffer,staining
R3754 T7011 T7003 punct .,resuspended
R3755 T7012 T7013 amod Anti-CD4,microbeads
R3756 T7013 T7019 nsubjpass microbeads,added
R3757 T7014 T7013 punct (,microbeads
R3758 T7015 T7016 nummod 20,μl
R3759 T7016 T7013 appos μl,microbeads
R3760 T7017 T7013 punct ),microbeads
R3761 T7018 T7019 auxpass were,added
R3762 T7019 T7019 ROOT added,added
R3763 T7020 T7019 cc and,added
R3764 T7021 T7019 conj incubated,added
R3765 T7022 T7021 prep for,incubated
R3766 T7023 T7024 nummod 15,min
R3767 T7024 T7022 pobj min,for
R3768 T7025 T7024 prep at,min
R3769 T7026 T7025 pobj 6,at
R3770 T7027 T7028 nummod 12,°
R3771 T7028 T7030 compound °,Saturating
R3772 T7029 T7030 compound C.,Saturating
R3773 T7030 T7031 nummod Saturating,amounts
R3774 T7031 T7036 nsubjpass amounts,added
R3775 T7032 T7031 prep of,amounts
R3776 T7033 T7034 amod fluorochrome-conjugated,antibodies
R3777 T7034 T7032 pobj antibodies,of
R3778 T7035 T7036 auxpass were,added
R3779 T7036 T7019 conj added,added
R3780 T7037 T7036 prep for,added
R3781 T7038 T7041 det a,min
R3782 T7039 T7041 amod further,min
R3783 T7040 T7041 nummod 10,min
R3784 T7041 T7037 pobj min,for
R3785 T7042 T7036 punct .,added
R3786 T7043 T7045 nsubjpass Cells,diluted
R3787 T7044 T7045 auxpass were,diluted
R3788 T7045 T7045 ROOT diluted,diluted
R3789 T7046 T7045 prep in,diluted
R3790 T7047 T7048 nummod 2.5,ml
R3791 T7048 T7046 pobj ml,in
R3792 T7049 T7048 prep of,ml
R3793 T7050 T7049 pobj FBS,of
R3794 T7051 T7052 compound staining,buffer
R3795 T7052 T7048 conj buffer,ml
R3796 T7053 T7048 punct ",",ml
R3797 T7054 T7056 amod pelleted,resuspended
R3798 T7055 T7056 punct ",",resuspended
R3799 T7056 T7045 conj resuspended,diluted
R3800 T7057 T7056 prep in,resuspended
R3801 T7058 T7059 nummod 500,μl
R3802 T7059 T7057 pobj μl,in
R3803 T7060 T7056 cc and,resuspended
R3804 T7061 T7062 advmod magnetically,separated
R3805 T7062 T7056 conj separated,resuspended
R3806 T7063 T7062 punct ",",separated
R3807 T7064 T7065 advmod usually,on
R3808 T7065 T7062 prep on,separated
R3809 T7066 T7068 det an,magnet
R3810 T7067 T7068 compound AutoMACS,magnet
R3811 T7068 T7065 pobj magnet,on
R3812 T7069 T7068 acl fitted,magnet
R3813 T7070 T7069 prep with,fitted
R3814 T7071 T7074 det a,column
R3815 T7072 T7074 compound MACS,column
R3816 T7073 T7074 compound MS,column
R3817 T7074 T7070 pobj column,with
R3818 T7075 T7045 punct .,diluted
R3819 T7076 T7076 ROOT Flow-through,Flow-through
R3820 T7077 T7076 cc and,Flow-through
R3821 T7078 T7081 nummod two,washes
R3822 T7079 T7080 nummod 1,ml
R3823 T7080 T7081 compound ml,washes
R3824 T7081 T7083 nsubjpass washes,collected
R3825 T7082 T7083 auxpass were,collected
R3826 T7083 T7076 conj collected,Flow-through
R3827 T7084 T7083 prep as,collected
R3828 T7085 T7087 det the,fraction
R3829 T7086 T7087 amod negative,fraction
R3830 T7087 T7084 pobj fraction,as
R3831 T7088 T7083 punct .,collected
R3832 T7089 T7090 amod Enriched,cells
R3833 T7090 T7092 nsubjpass cells,collected
R3834 T7091 T7092 auxpass were,collected
R3835 T7092 T7092 ROOT collected,collected
R3836 T7093 T7092 prep in,collected
R3837 T7094 T7097 nummod two,aliquots
R3838 T7095 T7096 nummod 0.5,ml
R3839 T7096 T7097 compound ml,aliquots
R3840 T7097 T7093 pobj aliquots,in
R3841 T7098 T7097 prep from,aliquots
R3842 T7099 T7100 det the,column
R3843 T7100 T7098 pobj column,from
R3844 T7101 T7100 prep after,column
R3845 T7102 T7101 pobj removal,after
R3846 T7103 T7102 prep from,removal
R3847 T7104 T7105 det the,magnet
R3848 T7105 T7103 pobj magnet,from
R3849 T7106 T7092 punct .,collected
R3850 T7107 T7110 advmod Alternatively,stained
R3851 T7108 T7110 punct ",",stained
R3852 T7109 T7110 nsubj cells,stained
R3853 T7110 T7110 ROOT stained,stained
R3854 T7111 T7110 prep with,stained
R3855 T7112 T7111 pobj anti-CD4,with
R3856 T7113 T7115 nsubjpass phycoerythrin,washed
R3857 T7114 T7115 auxpass were,washed
R3858 T7115 T7115 ROOT washed,washed
R3859 T7116 T7115 punct ",",washed
R3860 T7117 T7118 advmod magnetically,labeled
R3861 T7118 T7115 conj labeled,washed
R3862 T7119 T7118 prep with,labeled
R3863 T7120 T7121 amod anti-phycoerythrin,microbeads
R3864 T7121 T7119 pobj microbeads,with
R3865 T7122 T7125 punct (,added
R3866 T7123 T7124 nummod 20,μl
R3867 T7124 T7125 nsubj μl,added
R3868 T7125 T7125 ROOT added,added
R3869 T7126 T7125 prep to,added
R3870 T7127 T7128 nummod 80,μl
R3871 T7128 T7126 pobj μl,to
R3872 T7129 T7128 prep of,μl
R3873 T7130 T7131 compound cell,suspension
R3874 T7131 T7129 pobj suspension,of
R3875 T7132 T7125 punct ;,added
R3876 T7133 T7134 nummod 15,min
R3877 T7134 T7134 ROOT min,min
R3878 T7135 T7134 punct ",",min
R3879 T7136 T7134 appos 6,min
R3880 T7137 T7138 nummod 12,°
R3881 T7138 T7139 compound °,C
R3882 T7139 T7134 appos C,min
R3883 T7140 T7134 punct ),min
R3884 T7141 T7134 punct ",",min
R3885 T7142 T7134 cc and,min
R3886 T7143 T7144 advmod magnetically,separated
R3887 T7144 T7134 conj separated,min
R3888 T7145 T7146 mark as,described
R3889 T7146 T7144 advcl described,separated
R3890 T7147 T7146 advmod above,described
R3891 T7148 T7125 punct .,added
R3892 T7149 T7150 det The,purity
R3893 T7150 T7154 nsubjpass purity,assessed
R3894 T7151 T7150 prep of,purity
R3895 T7152 T7151 pobj cells,of
R3896 T7153 T7154 auxpass was,assessed
R3897 T7154 T7154 ROOT assessed,assessed
R3898 T7155 T7154 agent by,assessed
R3899 T7156 T7155 pobj flow,by
R3900 T7157 T7158 amod cytometric,analysis
R3901 T7158 T7154 npadvmod analysis,assessed
R3902 T7159 T7158 prep of,analysis
R3903 T7160 T7161 amod stained,cells
R3904 T7161 T7159 pobj cells,of
R3905 T7162 T7158 prep on,analysis
R3906 T7163 T7166 det a,sorter
R3907 T7164 T7166 compound FACS,sorter
R3908 T7165 T7166 compound Vantage,sorter
R3909 T7166 T7162 pobj sorter,on
R3910 T7167 T7154 punct .,assessed
R3911 T7168 T7179 nsubj Most,had
R3912 T7169 T7173 punct (,%
R3913 T7170 T7172 amod more,97
R3914 T7171 T7172 quantmod than,97
R3915 T7172 T7173 nummod 97,%
R3916 T7173 T7168 appos %,Most
R3917 T7174 T7173 punct ),%
R3918 T7175 T7173 prep of,%
R3919 T7176 T7178 det the,cells
R3920 T7177 T7178 amod isolated,cells
R3921 T7178 T7175 pobj cells,of
R3922 T7179 T7179 ROOT had,had
R3923 T7180 T7184 det the,marker
R3924 T7181 T7182 compound CD4,T
R3925 T7182 T7184 compound T,marker
R3926 T7183 T7184 compound cell,marker
R3927 T7184 T7179 dobj marker,had
R3928 T7185 T7179 punct .,had
R4194 T7843 T7845 amod Enzyme-linked,assay
R4195 T7844 T7845 amod immunosorbent,assay
R4196 T7845 T7853 nsubjpass assay,measured
R4197 T7846 T7845 prep of,assay
R4198 T7847 T7848 compound IL-17,IL-17
R4199 T7848 T7846 pobj IL-17,of
R4200 T7849 T7845 prep in,assay
R4201 T7850 T7851 compound culture,supernatants
R4202 T7851 T7849 pobj supernatants,in
R4203 T7852 T7853 auxpass was,measured
R4204 T7853 T7853 ROOT measured,measured
R4205 T7854 T7853 agent by,measured
R4206 T7855 T7858 nmod sandwich,assay
R4207 T7856 T7858 amod enzyme-linked,assay
R4208 T7857 T7858 compound immunosorbent,assay
R4209 T7858 T7854 pobj assay,by
R4210 T7859 T7860 mark as,described
R4211 T7860 T7853 advcl described,measured
R4212 T7861 T7864 advmod previously,]
R4213 T7862 T7864 nmod [,]
R4214 T7863 T7864 nummod 20,]
R4215 T7864 T7860 dobj ],described
R4216 T7865 T7853 punct .,measured
R4217 T7866 T7876 prep In,coated
R4218 T7867 T7866 pobj brief,In
R4219 T7868 T7876 punct ",",coated
R4220 T7869 T7871 det a,plate
R4221 T7870 T7871 amod 96-well,plate
R4222 T7871 T7876 nsubjpass plate,coated
R4223 T7872 T7873 punct (,Nunc
R4224 T7873 T7871 appos Nunc,plate
R4225 T7874 T7873 punct ),Nunc
R4226 T7875 T7876 auxpass was,coated
R4227 T7876 T7876 ROOT coated,coated
R4228 T7877 T7876 prep with,coated
R4229 T7878 T7879 nummod 4,μg
R4230 T7879 T7883 amod μg,antibodies
R4231 T7880 T7883 nmod /,antibodies
R4232 T7881 T7883 amod ml,antibodies
R4233 T7882 T7883 amod monoclonal,antibodies
R4234 T7883 T7877 pobj antibodies,with
R4235 T7884 T7883 prep against,antibodies
R4236 T7885 T7884 pobj IL-17,against
R4237 T7886 T7885 punct (,IL-17
R4238 T7887 T7885 conj R,IL-17
R4239 T7888 T7887 cc &,R
R4240 T7889 T7890 compound D,Systems
R4241 T7890 T7887 conj Systems,R
R4242 T7891 T7885 punct ),IL-17
R4243 T7892 T7876 prep at,coated
R4244 T7893 T7894 nummod 4,°
R4245 T7894 T7895 nummod °,C
R4246 T7895 T7896 compound C,overnight
R4247 T7896 T7892 pobj overnight,at
R4248 T7897 T7876 punct .,coated
R4249 T7898 T7910 prep After,/
R4250 T7899 T7898 pcomp blocking,After
R4251 T7900 T7899 prep with,blocking
R4252 T7901 T7906 amod phosphate-buffered,albumin
R4253 T7902 T7903 nummod saline/1,%
R4254 T7903 T7906 compound %,albumin
R4255 T7904 T7905 amod bovine,serum
R4256 T7905 T7906 compound serum,albumin
R4257 T7906 T7900 pobj albumin,with
R4258 T7907 T7908 punct (,BSA
R4259 T7908 T7906 npadvmod BSA,albumin
R4260 T7909 T7910 punct ),/
R4261 T7910 T7910 ROOT /,/
R4262 T7911 T7912 nummod 0.05,%
R4263 T7912 T7929 nmod %,samples
R4264 T7913 T7914 nummod Tween,20
R4265 T7914 T7929 nummod 20,samples
R4266 T7915 T7914 prep for,20
R4267 T7916 T7917 nummod 2,hours
R4268 T7917 T7915 pobj hours,for
R4269 T7918 T7917 prep at,hours
R4270 T7919 T7920 compound room,temperature
R4271 T7920 T7918 pobj temperature,at
R4272 T7921 T7917 punct (,hours
R4273 T7922 T7917 nummod 22,hours
R4274 T7923 T7925 nummod 25,C
R4275 T7924 T7925 compound °,C
R4276 T7925 T7917 appos C,hours
R4277 T7926 T7914 punct ),20
R4278 T7927 T7914 punct ",",20
R4279 T7928 T7929 compound test,samples
R4280 T7929 T7910 dobj samples,/
R4281 T7930 T7929 cc and,samples
R4282 T7931 T7934 det the,IL-17
R4283 T7932 T7934 amod standard,IL-17
R4284 T7933 T7934 compound recombinant,IL-17
R4285 T7934 T7929 conj IL-17,samples
R4286 T7935 T7942 punct (,added
R4287 T7936 T7942 nsubjpass R,added
R4288 T7937 T7936 cc &,R
R4289 T7938 T7939 compound D,Systems
R4290 T7939 T7936 conj Systems,R
R4291 T7940 T7942 punct ),added
R4292 T7941 T7942 auxpass were,added
R4293 T7942 T7934 parataxis added,IL-17
R4294 T7943 T7942 prep to,added
R4295 T7944 T7946 det the,plate
R4296 T7945 T7946 amod 96-well,plate
R4297 T7946 T7943 pobj plate,to
R4298 T7947 T7942 cc and,added
R4299 T7948 T7942 conj incubated,added
R4300 T7949 T7948 prep at,incubated
R4301 T7950 T7951 compound room,temperature
R4302 T7951 T7949 pobj temperature,at
R4303 T7952 T7948 prep for,incubated
R4304 T7953 T7954 nummod 2,hours
R4305 T7954 T7952 pobj hours,for
R4306 T7955 T7942 punct .,added
R4307 T7956 T7958 nsubjpass Plates,washed
R4308 T7957 T7958 auxpass were,washed
R4309 T7958 T7958 ROOT washed,washed
R4310 T7959 T7960 nummod four,times
R4311 T7960 T7958 npadvmod times,washed
R4312 T7961 T7958 prep with,washed
R4313 T7962 T7963 compound phosphate-buffered,saline/Tween
R4314 T7963 T7961 pobj saline/Tween,with
R4315 T7964 T7963 nummod 20,saline/Tween
R4316 T7965 T7958 punct ",",washed
R4317 T7966 T7958 cc and,washed
R4318 T7967 T7968 advmod then,incubated
R4319 T7968 T7958 conj incubated,washed
R4320 T7969 T7968 prep with,incubated
R4321 T7970 T7975 nummod 500,antibodies
R4322 T7971 T7975 amod ng/ml,antibodies
R4323 T7972 T7975 amod biotinylated,antibodies
R4324 T7973 T7975 compound mouse,antibodies
R4325 T7974 T7975 compound monoclonal,antibodies
R4326 T7975 T7969 pobj antibodies,with
R4327 T7976 T7975 prep against,antibodies
R4328 T7977 T7976 pobj IL-17,against
R4329 T7978 T7977 punct (,IL-17
R4330 T7979 T7977 conj R,IL-17
R4331 T7980 T7979 cc &,R
R4332 T7981 T7982 compound D,Systems
R4333 T7982 T7979 conj Systems,R
R4334 T7983 T7968 punct ),incubated
R4335 T7984 T7968 prep for,incubated
R4336 T7985 T7986 nummod 2,hours
R4337 T7986 T7984 pobj hours,for
R4338 T7987 T7986 prep at,hours
R4339 T7988 T7989 compound room,temperature
R4340 T7989 T7987 pobj temperature,at
R4341 T7990 T7958 punct .,washed
R4342 T7991 T8004 prep After,incubated
R4343 T7992 T7991 pcomp washing,After
R4344 T7993 T8004 punct ",",incubated
R4345 T7994 T8004 nsubjpass streptavidin,incubated
R4346 T7995 T7996 amod alkaline,phosphate
R4347 T7996 T8003 nsubj phosphate,was
R4348 T7997 T7999 amod horseradish,conjugate
R4349 T7998 T7999 amod peroxidase,conjugate
R4350 T7999 T7996 appos conjugate,phosphate
R4351 T8000 T8001 punct (,Sigma
R4352 T8001 T7999 appos Sigma,conjugate
R4353 T8002 T7999 punct ),conjugate
R4354 T8003 T8004 auxpass was,incubated
R4355 T8004 T8004 ROOT incubated,incubated
R4356 T8005 T8004 prep for,incubated
R4357 T8006 T8007 nummod 2,hours
R4358 T8007 T8005 pobj hours,for
R4359 T8008 T8010 punct ",",washed
R4360 T8009 T8010 advmod then,washed
R4361 T8010 T8004 dep washed,incubated
R4362 T8011 T8010 advmod again,washed
R4363 T8012 T8010 cc and,washed
R4364 T8013 T8010 conj incubated,washed
R4365 T8014 T8013 prep with,incubated
R4366 T8015 T8016 nummod 1,mg/ml
R4367 T8016 T8018 nmod mg/ml,phosphate
R4368 T8017 T8018 compound p-nitrophenyl,phosphate
R4369 T8018 T8014 pobj phosphate,with
R4370 T8019 T8020 punct (,Sigma
R4371 T8020 T8018 appos Sigma,phosphate
R4372 T8021 T8013 punct ),incubated
R4373 T8022 T8010 conj dissolved,washed
R4374 T8023 T8022 prep in,dissolved
R4375 T8024 T8023 pobj diethanolamine,in
R4376 T8025 T8026 punct (,Sigma
R4377 T8026 T8024 appos Sigma,diethanolamine
R4378 T8027 T8024 punct ),diethanolamine
R4379 T8028 T8029 aux to,develop
R4380 T8029 T8022 advcl develop,dissolved
R4454 T8103 T8101 pobj concentration,of
R4455 T8104 T8103 prep of,concentration
R4456 T8105 T8106 amod recombinant,cytokines
R4457 T8106 T8104 pobj cytokines,of
R4487 T8766 T8779 nsubjpass Quantification,incubated
R4488 T8767 T8766 prep of,Quantification
R4489 T8768 T8769 compound IL-17,mRNA
R4490 T8769 T8767 pobj mRNA,of
R4491 T8770 T8766 prep by,Quantification
R4492 T8771 T8773 amod semiquantitative,transcription
R4493 T8772 T8773 compound reverse,transcription
R4494 T8773 T8770 pobj transcription,by
R4495 T8774 T8776 compound polymerase,reaction
R4496 T8775 T8776 compound chain,reaction
R4497 T8776 T8777 compound reaction,PBMC
R4498 T8777 T8766 conj PBMC,Quantification
R4499 T8778 T8779 auxpass were,incubated
R4500 T8779 T8779 ROOT incubated,incubated
R4501 T8780 T8779 prep with,incubated
R4502 T8781 T8782 amod various,concentrations
R4503 T8782 T8780 pobj concentrations,with
R4504 T8783 T8782 prep of,concentrations
R4505 T8784 T8783 pobj anti-CD3,of
R4506 T8785 T8782 prep in,concentrations
R4507 T8786 T8787 det the,presence
R4508 T8787 T8785 pobj presence,in
R4509 T8788 T8787 cc or,presence
R4510 T8789 T8787 conj absence,presence
R4511 T8790 T8789 prep of,absence
R4512 T8791 T8790 pobj inhibitors,of
R4513 T8792 T8791 punct (,inhibitors
R4514 T8793 T8791 appos LY294002,inhibitors
R4515 T8794 T8791 punct ",",inhibitors
R4516 T8795 T8791 appos PDTC,inhibitors
R4517 T8796 T8791 punct ),inhibitors
R4518 T8797 T8779 punct .,incubated
R4519 T8798 T8806 prep After,extracted
R4520 T8799 T8800 nummod 16,hours
R4521 T8800 T8798 pobj hours,After
R4522 T8801 T8800 prep of,hours
R4523 T8802 T8801 pobj incubation,of
R4524 T8803 T8806 punct ",",extracted
R4525 T8804 T8806 nsubjpass mRNA,extracted
R4526 T8805 T8806 auxpass was,extracted
R4527 T8806 T8806 ROOT extracted,extracted
R4528 T8807 T8806 prep with,extracted
R4529 T8808 T8809 compound RNAzol,B
R4530 T8809 T8807 pobj B,with
R4531 T8810 T8812 punct (,Laboratories
R4532 T8811 T8812 compound Biotex,Laboratories
R4533 T8812 T8809 appos Laboratories,B
R4534 T8813 T8812 punct ",",Laboratories
R4535 T8814 T8812 conj Houston,Laboratories
R4536 T8815 T8814 punct ",",Houston
R4537 T8816 T8814 conj TX,Houston
R4538 T8817 T8816 punct ",",TX
R4539 T8818 T8816 conj USA,TX
R4540 T8819 T8812 punct ),Laboratories
R4541 T8820 T8806 prep in,extracted
R4542 T8821 T8820 pobj accordance,in
R4543 T8822 T8821 prep with,accordance
R4544 T8823 T8824 det the,manufacturer
R4545 T8824 T8826 poss manufacturer,instructions
R4546 T8825 T8824 case 's,manufacturer
R4547 T8826 T8822 pobj instructions,with
R4548 T8827 T8806 punct .,extracted
R4549 T8828 T8828 ROOT Reverse,Reverse
R4550 T8829 T8837 nsubjpass transcription,performed
R4551 T8830 T8829 prep of,transcription
R4552 T8831 T8832 nummod 2,μg
R4553 T8832 T8830 pobj μg,of
R4554 T8833 T8832 prep of,μg
R4555 T8834 T8835 amod total,mRNA
R4556 T8835 T8833 pobj mRNA,of
R4557 T8836 T8837 auxpass was,performed
R4558 T8837 T8828 ccomp performed,Reverse
R4559 T8838 T8837 prep at,performed
R4560 T8839 T8840 nummod 42,°
R4561 T8840 T8841 nummod °,C
R4562 T8841 T8838 pobj C,at
R4563 T8842 T8837 advcl using,performed
R4564 T8843 T8848 det the,system
R4565 T8844 T8848 nmod Superscript,system
R4566 T8845 T8848 compound ™,system
R4567 T8846 T8848 compound reverse,system
R4568 T8847 T8848 compound transcription,system
R4569 T8848 T8842 dobj system,using
R4570 T8849 T8848 punct (,system
R4571 T8850 T8848 appos Takara,system
R4572 T8851 T8850 punct ",",Takara
R4573 T8852 T8850 conj Shiga,Takara
R4574 T8853 T8852 punct ",",Shiga
R4575 T8854 T8852 npadvmod Japan,Shiga
R4576 T8855 T8852 punct ),Shiga
R4577 T8856 T8828 punct .,Reverse
R4578 T8857 T8858 compound PCR,amplification
R4579 T8858 T8863 nsubjpass amplification,performed
R4580 T8859 T8858 prep of,amplification
R4581 T8860 T8861 compound cDNA,aliquots
R4582 T8861 T8859 pobj aliquots,of
R4583 T8862 T8863 auxpass was,performed
R4584 T8863 T8863 ROOT performed,performed
R4585 T8864 T8863 prep by,performed
R4586 T8865 T8864 pcomp adding,by
R4587 T8866 T8868 nummod 2.5,dNTPs
R4588 T8867 T8868 compound mM,dNTPs
R4589 T8868 T8865 dobj dNTPs,adding
R4590 T8869 T8871 punct ",",U
R4591 T8870 T8871 nummod 2.5,U
R4592 T8871 T8868 appos U,dNTPs
R4593 T8872 T8871 prep of,U
R4594 T8873 T8875 compound Taq,polymerase
R4595 T8874 T8875 compound DNA,polymerase
R4596 T8875 T8872 pobj polymerase,of
R4597 T8876 T8877 punct (,Takara
R4598 T8877 T8875 appos Takara,polymerase
R4599 T8878 T8871 punct ),U
R4632 T8911 T8891 prep in,performed
R4633 T8912 T8914 det a,volume
R4634 T8913 T8914 amod total,volume
R4635 T8914 T8911 pobj volume,in
R4636 T8915 T8914 prep of,volume
R4637 T8916 T8917 nummod 25,μl
R4638 T8917 T8915 pobj μl,of
R4639 T8918 T8891 punct .,performed
R4640 T8919 T8921 det The,sense
R4641 T8920 T8921 amod following,sense
R4642 T8921 T8929 nsubjpass sense,used
R4700 T8979 T8948 appos C-3,antisense
R4701 T8980 T8979 case ',C-3
R4702 T8981 T8948 punct ;,antisense
R4703 T8982 T8983 compound GAPDH,antisense
R4704 T8983 T8948 appos antisense,antisense
R4705 T8984 T8983 punct ",",antisense
R4706 T8985 T8994 nummod 5,CC-3
R4707 T8986 T8994 punct ',CC-3
R4708 T8987 T8994 punct -,CC-3
R4709 T8988 T8994 compound CGT,CC-3
R4710 T8989 T8994 compound TCA,CC-3
R4711 T8990 T8994 compound GCT,CC-3
R4712 T8991 T8994 compound CAG,CC-3
R4713 T8992 T8994 compound GGA,CC-3
R4714 T8993 T8994 compound TGA,CC-3
R4715 T8994 T8948 appos CC-3,antisense
R4716 T8995 T8994 punct ',CC-3
R4717 T8996 T8929 punct .,used
R4718 T8997 T8999 nsubjpass Reactions,processed
R4740 T9019 T8999 dep s,processed
R4741 T9020 T9019 prep of,s
R4742 T9021 T9020 pobj denaturation,of
R4743 T9022 T8999 prep at,processed
R4744 T9023 T9024 nummod 94,°
R4745 T9024 T9025 nummod °,C
R4746 T9025 T9022 pobj C,at
R4747 T9026 T9025 punct ",",C
R4748 T9027 T9028 nummod 1,min
R4749 T9028 T9040 nsubj min,followed
R4750 T9029 T9028 prep of,min
R4751 T9030 T9029 pcomp annealing,of
R4752 T9031 T9030 prep at,annealing
R4753 T9032 T9034 nummod 56,C
R4754 T9033 T9034 nummod °,C
R4755 T9034 T9031 pobj C,at
R4756 T9035 T9034 prep for,C
R4757 T9036 T9035 pobj GAPDH,for
R4758 T9037 T9036 cc and,GAPDH
R4759 T9038 T9036 conj IL-17,GAPDH
R4760 T9039 T9034 punct ",",C
R4761 T9040 T8999 advcl followed,processed
R4762 T9041 T9040 prep by,followed
R4763 T9042 T9043 nummod 1,min
R4764 T9043 T9041 pobj min,by
R4765 T9044 T9043 prep of,min
R4766 T9045 T9044 pobj elongation,of
R4767 T9046 T9043 prep at,min
R4768 T9047 T9048 nummod 72,°
R4769 T9048 T9051 nummod °,rounds
R4770 T9049 T9050 compound C.,PCR
R4771 T9050 T9051 compound PCR,rounds
R4772 T9051 T9046 pobj rounds,at
R4773 T9052 T9053 auxpass were,repeated
R4774 T9053 T8999 conj repeated,processed
R4775 T9054 T9053 prep for,repeated
R4776 T9055 T9056 nummod 25,cycles
R4777 T9056 T9054 pobj cycles,for
R4778 T9057 T9063 acomp each,;
R4779 T9058 T9057 prep for,each
R4780 T9059 T9060 det both,GAPDH
R4781 T9060 T9058 pobj GAPDH,for
R4782 T9061 T9060 cc and,GAPDH
R4783 T9062 T9060 conj IL-17,GAPDH
R4784 T9063 T9066 punct ;,determined
R4785 T9064 T9066 nsubjpass this,determined
R4786 T9065 T9066 auxpass was,determined
R4787 T9066 T9066 ROOT determined,determined
R4788 T9067 T9066 prep as,determined
R4789 T9068 T9067 pcomp falling,as
R4790 T9069 T9068 prep within,falling
R4791 T9070 T9072 det the,phase
R4792 T9071 T9072 amod exponential,phase
R4793 T9072 T9069 pobj phase,within
R4794 T9073 T9072 prep of,phase
R4795 T9074 T9073 pobj amplification,of
R4796 T9075 T9068 prep for,falling
R4797 T9076 T9077 det each,molecule
R4798 T9077 T9075 pobj molecule,for
R4799 T9078 T9066 punct .,determined
R4800 T9079 T9080 det The,level
R4801 T9080 T9085 nsubjpass level,presented
R4802 T9081 T9080 prep of,level
R4803 T9082 T9083 compound mRNA,expression
R4804 T9083 T9081 pobj expression,of
R4805 T9084 T9085 auxpass was,presented
R4806 T9085 T9085 ROOT presented,presented
R4807 T9086 T9085 prep as,presented
R4808 T9087 T9088 det a,ratio
R4809 T9088 T9086 pobj ratio,as
R4810 T9089 T9088 prep of,ratio
R4811 T9090 T9092 compound IL-17,product
R4812 T9091 T9092 compound PCR,product
R4813 T9092 T9089 pobj product,of
R4814 T9093 T9088 prep over,ratio
R4815 T9094 T9095 compound GAPDH,product
R4816 T9095 T9093 pobj product,over
R4817 T9096 T9085 punct .,presented
R5095 T9702 T9703 nummod 10,μg
R5096 T9703 T9705 nmod μg,ml
R5097 T9704 T9705 compound /,ml
R5098 T9705 T9700 appos ml,anti-CD3
R5099 T9706 T9705 punct ),ml
R5100 T9707 T9698 prep in,incubated
R5101 T9708 T9709 det the,presence
R5102 T9709 T9707 pobj presence,in
R5103 T9710 T9709 cc or,presence
R5104 T9711 T9709 conj absence,presence
R5105 T9712 T9711 prep of,absence
R5106 T9713 T9712 pobj LY294002,of
R5107 T9714 T9716 punct (,μM
R5108 T9715 T9716 nummod 20,μM
R5109 T9716 T9713 appos μM,LY294002
R5110 T9717 T9716 punct ),μM
R5111 T9718 T9692 punct .,phosphorylated
R5112 T9719 T9729 prep After,prepared
R5113 T9720 T9719 pobj incubation,After
R5114 T9721 T9729 prep for,prepared
R5115 T9722 T9723 nummod 1,hour
R5116 T9723 T9721 pobj hour,for
R5117 T9724 T9729 punct ",",prepared
R5118 T9725 T9727 amod whole,lysates
R5119 T9726 T9727 compound cell,lysates
R5120 T9727 T9729 nsubjpass lysates,prepared
R5121 T9728 T9729 auxpass were,prepared
R5122 T9729 T9729 ROOT prepared,prepared
R5123 T9730 T9729 prep from,prepared
R5124 T9731 T9733 nmod about,cells
R5125 T9732 T9733 nummod 107,cells
R5126 T9733 T9730 pobj cells,from
R5127 T9734 T9733 prep by,cells
R5128 T9735 T9734 pobj homogenization,by
R5129 T9736 T9733 prep in,cells
R5130 T9737 T9739 det the,buffer
R5131 T9738 T9739 compound lysis,buffer
R5132 T9739 T9736 pobj buffer,in
R5133 T9740 T9729 punct ",",prepared
R5134 T9741 T9729 cc and,prepared
R5135 T9742 T9729 conj centrifuged,prepared
R5136 T9743 T9742 prep at,centrifuged
R5137 T9744 T9745 nummod "14,000",r.p.m.
R5138 T9745 T9743 pobj r.p.m.,at
R5139 T9746 T9745 punct (,r.p.m.
R5140 T9747 T9748 nummod "19,000",g
R5141 T9748 T9745 appos g,r.p.m.
R5142 T9749 T9745 punct ),r.p.m.
R5143 T9750 T9742 prep for,centrifuged
R5144 T9751 T9752 nummod 15,min
R5145 T9752 T9750 pobj min,for
R5146 T9753 T9729 punct .,prepared
R5147 T9754 T9755 compound Protein,concentrations
R5148 T9755 T9760 nsubjpass concentrations,determined
R5149 T9756 T9755 prep in,concentrations
R5150 T9757 T9758 det the,supernatants
R5151 T9758 T9756 pobj supernatants,in
R5152 T9759 T9760 auxpass were,determined
R5153 T9760 T9760 ROOT determined,determined
R5154 T9761 T9760 prep with,determined
R5155 T9762 T9764 det the,method
R5156 T9763 T9764 compound Bradford,method
R5157 T9764 T9761 pobj method,with
R5158 T9765 T9766 punct (,Bio-Rad
R5159 T9766 T9764 appos Bio-Rad,method
R5160 T9767 T9766 punct ",",Bio-Rad
R5161 T9768 T9766 conj Hercules,Bio-Rad
R5162 T9769 T9768 punct ",",Hercules
R5163 T9770 T9768 conj CA,Hercules
R5164 T9771 T9770 punct ",",CA
R5165 T9772 T9770 conj USA,CA
R5166 T9773 T9766 punct ),Bio-Rad
R5167 T9774 T9760 punct .,determined
R5168 T9775 T9776 compound Protein,samples
R5169 T9776 T9778 nsubjpass samples,separated
R5170 T9777 T9778 auxpass were,separated
R5171 T9778 T9778 ROOT separated,separated
R5172 T9779 T9778 prep by,separated
R5173 T9780 T9781 nummod 10,%
R5174 T9781 T9779 pobj %,by
R5175 T9782 T9783 compound SDS,PAGE
R5176 T9783 T9778 npadvmod PAGE,separated
R5177 T9784 T9778 cc and,separated
R5178 T9785 T9778 conj transferred,separated
R5179 T9786 T9785 prep to,transferred
R5180 T9787 T9789 det a,membrane
R5181 T9788 T9789 amod nitrocellulose,membrane
R5182 T9789 T9786 pobj membrane,to
R5183 T9790 T9793 punct (,Biotech
R5184 T9791 T9793 compound Amersham,Biotech
R5185 T9792 T9793 compound Pharmacia,Biotech
R5186 T9793 T9789 appos Biotech,membrane
R5187 T9794 T9793 punct ",",Biotech
R5188 T9795 T9793 conj Uppsala,Biotech
R5189 T9796 T9795 punct ",",Uppsala
R5190 T9797 T9795 conj Sweden,Uppsala
R5191 T9798 T9793 punct ),Biotech
R5192 T9799 T9778 punct .,separated
R5193 T9800 T9806 prep For,preincubated
R5194 T9801 T9802 amod western,hybridization
R5195 T9802 T9800 pobj hybridization,For
R5196 T9803 T9806 punct ",",preincubated
R5197 T9804 T9806 nsubjpass membrane,preincubated
R5198 T9805 T9806 auxpass was,preincubated
R5199 T9806 T9806 ROOT preincubated,preincubated
R5200 T9807 T9806 prep with,preincubated
R5201 T9808 T9809 nummod 0.1,%
R5202 T9809 T9810 nsubj %,skimmed
R5203 T9810 T9806 conj skimmed,preincubated
R5204 T9811 T9810 dobj milk,skimmed
R5205 T9812 T9810 prep in,skimmed
R5206 T9813 T9814 compound TBS-T,buffer
R5207 T9814 T9812 pobj buffer,in
R5208 T9815 T9817 punct (,%
R5209 T9816 T9817 nummod 0.1,%
R5210 T9817 T9837 nsubj %,phosphorylated
R5211 T9818 T9819 nummod Tween,20
R5212 T9819 T9837 dep 20,phosphorylated
R5213 T9820 T9819 prep in,20
R5214 T9821 T9822 amod Tris-buffered,saline
R5215 T9822 T9820 pobj saline,in
R5216 T9823 T9819 punct ),20
R5217 T9824 T9819 prep at,20
R5218 T9825 T9826 compound room,temperature
R5219 T9826 T9824 pobj temperature,at
R5220 T9827 T9819 prep for,20
R5221 T9828 T9829 nummod 2,hours
R5222 T9829 T9827 pobj hours,for
R5223 T9830 T9819 punct ",",20
R5224 T9831 T9833 advmod then,antibodies
R5225 T9832 T9833 amod primary,antibodies
R5226 T9833 T9819 appos antibodies,20
R5227 T9834 T9833 prep against,antibodies
R5228 T9835 T9834 pobj Akt,against
R5229 T9836 T9819 punct ",",20
R5230 T9837 T9810 advcl phosphorylated,skimmed
R5231 T9838 T9837 dobj Akt,phosphorylated
R5232 T9839 T9838 cc and,Akt
R5233 T9840 T9838 conj IκB-α,Akt
R5234 T9841 T9845 punct (,Inc.
R5235 T9842 T9845 compound Cell,Inc.
R5236 T9843 T9845 compound Signaling,Inc.
R5237 T9844 T9845 compound Technology,Inc.
R5238 T9845 T9838 conj Inc.,Akt
R5239 T9846 T9845 punct ",",Inc.
R5240 T9847 T9845 npadvmod Beverly,Inc.
R5241 T9848 T9847 punct ",",Beverly
R5242 T9849 T9847 conj MA,Beverly
R5243 T9850 T9849 punct ",",MA
R5244 T9851 T9849 npadvmod USA,MA
R5245 T9852 T9849 punct ),MA
R5246 T9853 T9845 punct ",",Inc.
R5247 T9854 T9837 prep diluted,phosphorylated
R5248 T9855 T9854 npadvmod 1:1000,diluted
R5249 T9856 T9855 prep in,1:1000
R5250 T9857 T9858 nummod 5,%
R5251 T9858 T9859 compound %,BSA/TBS-T
R5252 T9859 T9856 pobj BSA/TBS-T,in
R5253 T9860 T9862 punct ",",added
R5254 T9861 T9862 auxpass were,added
R5255 T9862 T9806 conj added,preincubated
R5256 T9863 T9862 cc and,added
R5290 T9897 T9895 pcomp washing,After
R5291 T9898 T9902 punct ",",detected
R5292 T9899 T9900 amod hybridized,bands
R5293 T9900 T9902 nsubjpass bands,detected
R5294 T9901 T9902 auxpass were,detected
R5295 T9902 T9902 ROOT detected,detected
R5296 T9903 T9902 prep with,detected
R5297 T9904 T9906 det the,chemiluminescence
R5298 T9905 T9906 amod enhanced,chemiluminescence
R5299 T9906 T9903 pobj chemiluminescence,with
R5300 T9907 T9906 punct (,chemiluminescence
R5301 T9908 T9906 appos ECL,chemiluminescence
R5302 T9909 T9911 punct ),kit
R5303 T9910 T9911 compound detection,kit
R5304 T9911 T9906 conj kit,chemiluminescence
R5305 T9912 T9911 cc and,kit
R5306 T9913 T9914 amod Hyperfilm-ECL,reagents
R5307 T9914 T9911 conj reagents,kit
R5308 T9915 T9917 punct (,Pharmacia
R5309 T9916 T9917 compound Amersham,Pharmacia
R5310 T9917 T9914 appos Pharmacia,reagents
R5311 T9918 T9914 punct ),reagents
R5312 T9919 T9902 punct .,detected
R5544 T10457 T10459 nmod Gel,assay
R5545 T10458 T10459 amod mobility-shift,assay
R5546 T10459 T10467 nsubjpass assay,extracted
R5547 T10460 T10459 prep of,assay
R5548 T10461 T10463 amod NF-κB,site
R5549 T10462 T10463 amod binding,site
R5550 T10463 T10465 compound site,proteins
R5551 T10464 T10465 compound Nuclear,proteins
R5552 T10465 T10460 pobj proteins,of
R5553 T10466 T10467 auxpass were,extracted
R5554 T10467 T10467 ROOT extracted,extracted
R5555 T10468 T10467 prep from,extracted
R5556 T10469 T10473 nmod about,PBMC
R5557 T10470 T10473 nummod 5,PBMC
R5558 T10471 T10473 nummod ×,PBMC
R5559 T10472 T10473 nummod 106,PBMC
R5560 T10473 T10468 pobj PBMC,from
R5561 T10474 T10467 punct .,extracted
R5562 T10475 T10476 compound Oligonucleotide,probes
R5563 T10476 T10502 nsubjpass probes,generated
R5564 T10477 T10476 acl encompassing,probes
R5565 T10478 T10481 det the,site
R5566 T10479 T10481 amod NF-κB,site
R5567 T10480 T10481 amod binding,site
R5568 T10481 T10477 dobj site,encompassing
R5569 T10482 T10481 prep of,site
R5570 T10483 T10486 det the,promoter
R5571 T10484 T10486 amod human,promoter
R5572 T10485 T10486 compound IL-17,promoter
R5573 T10486 T10482 pobj promoter,of
R5574 T10487 T10486 punct (,promoter
R5575 T10488 T10486 appos 5,promoter
R5576 T10489 T10486 punct ',promoter
R5577 T10490 T10502 punct -,generated
R5578 T10491 T10502 nsubjpass ATG,generated
R5579 T10492 T10502 nsubjpass ACC,generated
R5580 T10493 T10495 compound TGG,TAC
R5581 T10494 T10495 compound AAA,TAC
R5582 T10495 T10502 nsubjpass TAC,generated
R5583 T10496 T10497 compound CCA,AAA
R5584 T10497 T10498 compound AAA,TTC-3
R5585 T10498 T10495 appos TTC-3,TAC
R5586 T10499 T10495 punct ',TAC
R5587 T10500 T10495 punct ),TAC
R5588 T10501 T10502 auxpass were,generated
R5589 T10502 T10502 ROOT generated,generated
R5590 T10503 T10502 agent by,generated
R5591 T10504 T10503 pobj 5,by
R5592 T10505 T10504 punct ',5
R5593 T10506 T10507 punct -,end
R5594 T10507 T10508 compound end,labeling
R5595 T10508 T10502 dobj labeling,generated
R5596 T10509 T10508 prep of,labeling
R5597 T10510 T10512 det the,strand
R5598 T10511 T10512 compound sense,strand
R5599 T10512 T10509 pobj strand,of
R5600 T10513 T10512 prep with,strand
R5601 T10514 T10517 compound [,dATP
R5602 T10515 T10517 compound γ-32P,dATP
R5603 T10516 T10517 compound ],dATP
R5604 T10517 T10513 pobj dATP,with
R5605 T10518 T10520 punct (,Pharmacia
R5606 T10519 T10520 compound Amersham,Pharmacia
R5607 T10520 T10517 appos Pharmacia,dATP
R5608 T10521 T10520 punct ),Pharmacia
R5609 T10522 T10517 cc and,dATP
R5610 T10523 T10525 nummod T4,kinase
R5611 T10524 T10525 compound polynucleotide,kinase
R5612 T10525 T10517 conj kinase,dATP
R5613 T10526 T10525 punct (,kinase
R5614 T10527 T10525 appos TaKaRa,kinase
R5615 T10528 T10525 punct ),kinase
R5616 T10529 T10502 punct .,generated
R5617 T10530 T10531 compound Unincorporated,nucleotides
R5618 T10531 T10533 nsubjpass nucleotides,removed
R5619 T10532 T10533 auxpass were,removed
R5620 T10533 T10533 ROOT removed,removed
R5621 T10534 T10533 agent by,removed
R5622 T10535 T10538 nmod NucTrap,columns
R5623 T10536 T10537 compound probe,purification
R5624 T10537 T10538 compound purification,columns
R5625 T10538 T10534 pobj columns,by
R5626 T10539 T10538 punct (,columns
R5627 T10540 T10538 appos Stratagene,columns
R5628 T10541 T10540 punct ",",Stratagene
R5629 T10542 T10543 compound La,Jolla
R5630 T10543 T10540 conj Jolla,Stratagene
R5631 T10544 T10543 punct ",",Jolla
R5632 T10545 T10543 conj CA,Jolla
R5633 T10546 T10545 punct ",",CA
R5634 T10547 T10545 conj USA,CA
R5635 T10548 T10538 punct ),columns
R5636 T10549 T10533 punct .,removed
R5637 T10550 T10551 compound Nuclear,extracts
R5638 T10551 T10559 nsubjpass extracts,incubated
R5639 T10552 T10554 punct (,μg
R5640 T10553 T10554 nummod 2,μg
R5641 T10554 T10551 appos μg,extracts
R5642 T10555 T10554 prep of,μg
R5643 T10556 T10555 pobj protein,of
R5644 T10557 T10554 punct ),μg
R5645 T10558 T10559 auxpass were,incubated
R5646 T10559 T10559 ROOT incubated,incubated
R5647 T10560 T10559 prep with,incubated
R5648 T10561 T10563 amod radiolabeled,probes
R5649 T10562 T10563 compound DNA,probes
R5650 T10563 T10560 pobj probes,with
R5651 T10564 T10566 punct (,ng
R5652 T10565 T10566 nummod 10,ng
R5653 T10566 T10563 appos ng,probes
R5654 T10567 T10566 punct ;,ng
R5655 T10568 T10569 nummod "100,000",c.p.m.
R5656 T10569 T10566 appos c.p.m.,ng
R5657 T10570 T10566 punct ),ng
R5658 T10571 T10566 prep for,ng
R5659 T10572 T10573 nummod 30,min
R5660 T10573 T10571 pobj min,for
R5661 T10574 T10573 prep at,min
R5662 T10575 T10576 compound room,temperature
R5663 T10576 T10574 pobj temperature,at
R5664 T10577 T10573 prep in,min
R5665 T10578 T10579 nummod 20,μl
R5666 T10579 T10577 pobj μl,in
R5667 T10580 T10579 prep of,μl
R5668 T10581 T10582 amod binding,buffer
R5669 T10582 T10580 pobj buffer,of
R5670 T10583 T10582 acl consisting,buffer
R5671 T10584 T10583 prep of,consisting
R5672 T10585 T10587 nummod 20,Tris-HCl
R5673 T10586 T10587 compound mM,Tris-HCl
R5674 T10587 T10584 pobj Tris-HCl,of
R5675 T10588 T10587 punct ",",Tris-HCl
R5676 T10589 T10587 appos pH,Tris-HCl
R5677 T10590 T10589 nummod 7.9,pH
R5678 T10591 T10589 punct ",",pH
R5679 T10592 T10594 nummod 50,KCl
R5680 T10593 T10594 compound mM,KCl
R5681 T10594 T10587 appos KCl,Tris-HCl
R5682 T10595 T10594 punct ",",KCl
R5683 T10596 T10598 nummod 1,dithiothreitol
R5684 T10597 T10598 compound mM,dithiothreitol
R5685 T10598 T10594 appos dithiothreitol,KCl
R5686 T10599 T10598 punct ",",dithiothreitol
R5687 T10600 T10602 nummod 0.5,EDTA
R5688 T10601 T10602 compound mM,EDTA
R5689 T10602 T10598 appos EDTA,dithiothreitol
R5690 T10603 T10602 punct ",",EDTA
R5691 T10604 T10605 nummod 5,%
R5692 T10605 T10606 compound %,glycerol
R5693 T10606 T10602 appos glycerol,EDTA
R5694 T10607 T10606 punct ",",glycerol
R5695 T10608 T10609 nummod 1,mg/ml
R5696 T10609 T10610 compound mg/ml,BSA
R5697 T10610 T10602 appos BSA,EDTA
R5698 T10611 T10602 punct ",",EDTA
R5699 T10612 T10613 nummod 0.2,%
R5700 T10613 T10615 compound %,P40
R5701 T10614 T10615 compound Nonidet,P40
R5702 T10615 T10602 conj P40,EDTA
R5703 T10616 T10615 cc and,P40
R5704 T10617 T10618 nummod 50,ng
R5705 T10618 T10621 compound ng,poly
R5706 T10619 T10621 compound /,poly
R5707 T10620 T10621 compound μl,poly
R5708 T10621 T10615 conj poly,P40
R5709 T10622 T10623 punct (,dI-dC
R5710 T10623 T10621 parataxis dI-dC,poly
R5711 T10624 T10623 punct ),dI-dC
R5712 T10625 T10559 punct .,incubated
R5713 T10626 T10628 nsubjpass Samples,subjected
R5714 T10627 T10628 auxpass were,subjected
R5715 T10628 T10628 ROOT subjected,subjected
R5716 T10629 T10628 prep to,subjected
R5717 T10630 T10629 pobj electrophoresis,to
R5718 T10631 T10630 prep on,electrophoresis
R5719 T10632 T10631 pcomp nondenaturing,on
R5720 T10633 T10634 nummod 5,%
R5721 T10634 T10636 compound %,gels
R5722 T10635 T10636 compound polyacrylamide,gels
R5723 T10636 T10632 dobj gels,nondenaturing
R5724 T10637 T10632 prep in,nondenaturing
R5725 T10638 T10641 nummod 0.5,buffer
R5726 T10639 T10641 nummod ×,buffer
R5727 T10640 T10641 compound Tris-borate-EDTA,buffer
R5728 T10641 T10637 pobj buffer,in
R5729 T10642 T10643 punct (,pH
R5730 T10643 T10629 pobj pH,to
R5731 T10644 T10643 nummod 8.0,pH
R5732 T10645 T10643 punct ),pH
R5733 T10646 T10628 prep at,subjected
R5734 T10647 T10649 nummod 100,Gels
R5735 T10648 T10649 compound V.,Gels
R5736 T10649 T10646 pobj Gels,at
R5737 T10650 T10651 auxpass were,dried
R5738 T10651 T10628 conj dried,subjected
R5739 T10652 T10651 prep under,dried
R5740 T10653 T10652 pobj vacuum,under
R5741 T10654 T10651 cc and,dried
R5742 T10655 T10651 conj exposed,dried
R5743 T10656 T10655 prep to,exposed
R5744 T10657 T10659 compound Kodak,film
R5745 T10658 T10659 compound X-OMAT,film
R5746 T10659 T10656 pobj film,to
R5747 T10660 T10655 prep at,exposed
R5748 T10661 T10662 nummod -70,°
R5749 T10662 T10660 pobj °,at
R5750 T10663 T10655 npadvmod C,exposed
R5751 T10664 T10655 prep with,exposed
R5752 T10665 T10666 amod intensifying,screens
R5753 T10666 T10664 pobj screens,with
R5754 T10667 T10628 punct .,subjected
R5755 T10668 T10670 compound Rabbit,antibodies
R5756 T10669 T10670 compound polyclonal,antibodies
R5757 T10670 T10673 nsubj antibodies,subunits
R5758 T10671 T10670 prep against,antibodies
R5759 T10672 T10671 pobj NF-κB,against
R5760 T10673 T10673 ROOT subunits,subunits
R5761 T10674 T10673 dobj p50,subunits
R5762 T10675 T10674 punct ",",p50
R5763 T10676 T10674 conj p65,p50
R5764 T10677 T10679 cc and,were
R5765 T10678 T10679 nsubj c-Rel,were
R5766 T10679 T10679 ROOT were,were
R5767 T10680 T10679 prep from,were
R5768 T10681 T10683 compound Santa,Biotechnology
R5769 T10682 T10683 compound Cruz,Biotechnology
R5770 T10683 T10680 pobj Biotechnology,from
R5771 T10684 T10683 punct (,Biotechnology
R5772 T10685 T10686 compound Santa,Cruz
R5773 T10686 T10683 appos Cruz,Biotechnology
R5774 T10687 T10683 punct ",",Biotechnology
R5775 T10688 T10683 conj CA,Biotechnology
R5776 T10689 T10688 punct ",",CA
R5777 T10690 T10688 conj USA,CA
R5778 T10691 T10679 punct ),were
R5779 T10692 T10679 punct .,were
R5856 T10901 T10902 compound Cell,viability
R5857 T10902 T10902 ROOT viability,viability
R5858 T10903 T10908 punct (,assay
R5859 T10904 T10908 nmod Trypan,assay
R5860 T10905 T10906 amod blue,dye
R5861 T10906 T10908 nmod dye,assay
R5862 T10907 T10908 compound exclusion,assay
R5863 T10908 T10902 appos assay,viability
R5864 T10909 T10902 punct ),viability
R5865 T10910 T10922 prep For,used
R5866 T10911 T10912 compound cell,viability
R5867 T10912 T10913 compound viability,assays
R5868 T10913 T10910 pobj assays,For
R5869 T10914 T10922 punct ",",used
R5870 T10915 T10920 det the,method
R5871 T10916 T10920 amod trypan,method
R5872 T10917 T10918 amod blue,dye
R5873 T10918 T10919 compound dye,exclusion
R5874 T10919 T10920 compound exclusion,method
R5875 T10920 T10922 nsubjpass method,used
R5876 T10921 T10922 auxpass was,used
R5877 T10922 T10922 ROOT used,used
R5878 T10923 T10924 aux to,evaluate
R5879 T10924 T10922 xcomp evaluate,used
R5880 T10925 T10926 det the,potential
R5881 T10926 T10924 dobj potential,evaluate
R5882 T10927 T10926 prep of,potential
R5883 T10928 T10930 amod direct,effect
R5884 T10929 T10930 amod cytotoxic,effect
R5885 T10930 T10927 pobj effect,of
R5886 T10931 T10930 prep of,effect
R5887 T10932 T10931 pobj inhibitors,of
R5888 T10933 T10932 prep on,inhibitors
R5889 T10934 T10933 pobj cells,on
R5890 T10935 T10922 punct .,used
R5891 T10936 T10945 prep After,harvested
R5892 T10937 T10936 pobj incubation,After
R5893 T10938 T10937 prep for,incubation
R5894 T10939 T10940 nummod 24,hours
R5895 T10940 T10938 pobj hours,for
R5896 T10941 T10945 punct ",",harvested
R5897 T10942 T10943 det the,cells
R5898 T10943 T10945 nsubjpass cells,harvested
R5899 T10944 T10945 auxpass were,harvested
R5900 T10945 T10945 ROOT harvested,harvested
R5901 T10946 T10945 cc and,harvested
R5902 T10947 T10950 det the,viability
R5903 T10948 T10949 compound percentage,cell
R5904 T10949 T10950 compound cell,viability
R5905 T10950 T10952 nsubjpass viability,calculated
R5906 T10951 T10952 auxpass was,calculated
R5907 T10952 T10945 conj calculated,harvested
R5908 T10953 T10952 prep with,calculated
R5909 T10954 T10955 det the,formula
R5910 T10955 T10953 pobj formula,with
R5911 T10956 T10957 nummod 100,×
R5912 T10957 T10972 npadvmod ×,]
R5913 T10958 T10959 punct (,number
R5914 T10959 T10972 nmod number,]
R5915 T10960 T10959 prep of,number
R5916 T10961 T10962 amod viable,cells/number
R5917 T10962 T10960 pobj cells/number,of
R5918 T10963 T10962 prep of,cells/number
R5919 T10964 T10965 preconj both,viable
R5920 T10965 T10968 amod viable,cells
R5921 T10966 T10965 cc and,viable
R5922 T10967 T10965 conj dead,viable
R5923 T10968 T10963 pobj cells,of
R5924 T10969 T10959 punct ),number
R5925 T10970 T10972 quantmod [,]
R5926 T10971 T10972 nummod 21,]
R5927 T10972 T10952 conj ],calculated
R5928 T10973 T10952 punct .,calculated
R5957 T11046 T11047 compound Statistical,analysis
R5958 T11047 T11048 compound analysis,Data
R5959 T11048 T11050 nsubjpass Data,expressed
R5960 T11049 T11050 auxpass are,expressed
R5961 T11050 T11050 ROOT expressed,expressed
R5962 T11051 T11052 mark as,means
R5963 T11052 T11050 advcl means,expressed
R5964 T11053 T11054 compound ±,SEM
R5965 T11054 T11052 dobj SEM,means
R5966 T11055 T11054 punct .,SEM
R5967 T11056 T11057 compound Statistical,analysis
R5968 T11057 T11059 nsubjpass analysis,performed
R5969 T11058 T11059 auxpass was,performed
R5970 T11059 T11059 ROOT performed,performed
R5971 T11060 T11059 prep with,performed
R5972 T11061 T11060 pobj Student,with
R5973 T11062 T11061 case 's,Student
R5974 T11063 T11061 amod t-test,Student
R5975 T11064 T11063 prep for,t-test
R5976 T11065 T11066 amod matched,pairs
R5977 T11066 T11064 pobj pairs,for
R5978 T11067 T11059 punct .,performed
R5979 T11068 T11069 nsubj P,values
R5980 T11069 T11069 ROOT values,values
R5981 T11070 T11072 amod less,0.05
R5982 T11071 T11072 quantmod than,0.05
R5983 T11072 T11074 nsubjpass 0.05,considered
R5984 T11073 T11074 auxpass were,considered
R5985 T11074 T11069 ccomp considered,values
R5986 T11075 T11074 oprd significant,considered
R5987 T11076 T11069 punct .,values
R6160 T11434 T11435 compound IL-17,production
R6161 T11435 T11451 nsubjpass production,separated
R6162 T11436 T11435 prep in,production
R6163 T11437 T11436 pobj PBMC,in
R6164 T11438 T11435 prep from,production
R6165 T11439 T11438 pobj patients,from
R6166 T11440 T11439 prep with,patients
R6167 T11441 T11440 pobj RA,with
R6168 T11442 T11439 punct ",",patients
R6169 T11443 T11451 nsubjpass patients,separated
R6170 T11444 T11443 prep with,patients
R6171 T11445 T11444 pobj OA,with
R6172 T11446 T11445 cc and,OA
R6173 T11447 T11448 amod normal,individuals
R6174 T11448 T11445 conj individuals,OA
R6175 T11449 T11445 conj PBMC,OA
R6176 T11450 T11451 auxpass were,separated
R6177 T11451 T11480 ccomp separated,determined
R6178 T11452 T11451 cc and,separated
R6179 T11453 T11451 conj cultured,separated
R6180 T11454 T11453 prep with,cultured
R6181 T11455 T11454 pobj PHA,with
R6182 T11456 T11455 punct (,PHA
R6183 T11457 T11458 nummod 5,μg
R6184 T11458 T11460 compound μg,ml
R6185 T11459 T11460 compound /,ml
R6186 T11460 T11455 appos ml,PHA
R6187 T11461 T11455 punct ),PHA
R6188 T11462 T11453 prep from,cultured
R6189 T11463 T11462 pobj patients,from
R6190 T11464 T11463 prep with,patients
R6191 T11465 T11464 pobj RA,with
R6192 T11466 T11463 punct ",",patients
R6193 T11467 T11463 appos patients,patients
R6194 T11468 T11467 prep with,patients
R6195 T11469 T11468 pobj OA,with
R6196 T11470 T11469 punct ",",OA
R6197 T11471 T11469 cc and,OA
R6198 T11472 T11474 amod age-matched,controls
R6199 T11473 T11474 amod normal,controls
R6200 T11474 T11469 conj controls,OA
R6201 T11475 T11480 punct ;,determined
R6202 T11476 T11477 compound IL-17,levels
R6203 T11477 T11480 nsubjpass levels,determined
R6204 T11478 T11480 auxpass were,determined
R6205 T11479 T11480 advmod then,determined
R6206 T11480 T11480 ROOT determined,determined
R6207 T11481 T11480 prep in,determined
R6208 T11482 T11484 det the,supernatants
R6209 T11483 T11484 compound culture,supernatants
R6210 T11484 T11481 pobj supernatants,in
R6211 T11485 T11480 punct (,determined
R6212 T11486 T11488 nmod Fig.,)
R6213 T11487 T11486 nummod 1,Fig.
R6214 T11488 T11480 punct ),determined
R6215 T11489 T11480 punct .,determined
R6216 T11490 T11497 mark Although,were
R6217 T11491 T11492 det the,amounts
R6218 T11492 T11497 nsubj amounts,were
R6219 T11493 T11492 prep of,amounts
R6220 T11494 T11496 amod basal,secretion
R6221 T11495 T11496 compound IL-17,secretion
R6222 T11496 T11493 pobj secretion,of
R6223 T11497 T11530 advcl were,was
R6224 T11498 T11497 neg not,were
R6225 T11499 T11497 acomp different,were
R6226 T11500 T11499 prep between,different
R6227 T11501 T11506 nmod RA,controls
R6228 T11502 T11501 punct ",",RA
R6229 T11503 T11501 conj OA,RA
R6230 T11504 T11503 cc and,OA
R6231 T11505 T11506 amod normal,controls
R6232 T11506 T11500 pobj controls,between
R6233 T11507 T11499 punct (,different
R6234 T11508 T11509 nummod 62,±
R6235 T11509 T11521 npadvmod ±,respectively
R6236 T11510 T11509 nummod 31,±
R6237 T11511 T11509 punct ",",±
R6238 T11512 T11518 quantmod 43,10
R6239 T11513 T11518 quantmod ±,10
R6240 T11514 T11513 nummod 19,±
R6241 T11515 T11513 cc and,±
R6242 T11516 T11518 quantmod 43,10
R6243 T11517 T11518 quantmod ±,10
R6244 T11518 T11519 nummod 10,pg/ml
R6245 T11519 T11509 appos pg/ml,±
R6246 T11520 T11509 punct ",",±
R6247 T11521 T11497 advmod respectively,were
R6248 T11522 T11497 punct ),were
R6249 T11523 T11530 punct ",",was
R6250 T11524 T11526 det the,production
R6251 T11525 T11526 compound IL-17,production
R6252 T11526 T11530 nsubj production,was
R6253 T11527 T11526 acl stimulated,production
R6254 T11528 T11527 agent by,stimulated
R6255 T11529 T11528 pobj PHA,by
R6256 T11530 T11530 ROOT was,was
R6257 T11531 T11532 advmod significantly,higher
R6258 T11532 T11530 acomp higher,was
R6259 T11533 T11530 prep in,was
R6260 T11534 T11535 compound RA,PBMC
R6261 T11535 T11533 pobj PBMC,in
R6262 T11536 T11530 prep than,was
R6263 T11537 T11536 prep in,than
R6264 T11538 T11537 pobj those,in
R6265 T11539 T11538 prep from,those
R6266 T11540 T11539 pobj OA,from
R6267 T11541 T11540 cc and,OA
R6268 T11542 T11540 conj controls,OA
R6269 T11543 T11540 punct (,OA
R6270 T11544 T11546 nummod 768,295
R6271 T11545 T11546 nummod ±,295
R6272 T11546 T11554 npadvmod 295,<
R6273 T11547 T11546 prep versus,295
R6274 T11548 T11550 nummod 463,211
R6275 T11549 T11550 nummod ±,211
R6276 T11550 T11547 pobj 211,versus
R6277 T11551 T11553 amod pg/ml,P
R6278 T11552 T11553 compound [,P
R6279 T11553 T11554 nsubj P,<
R6280 T11554 T11564 dep <,<
R6281 T11555 T11556 nummod 0.05,]
R6282 T11556 T11554 dobj ],<
R6283 T11557 T11556 cc and,]
R6284 T11558 T11560 nummod 241,29
R6285 T11559 T11560 nummod ±,29
R6286 T11560 T11563 nummod 29,P
R6287 T11561 T11563 compound pg/ml,P
R6288 T11562 T11563 compound [,P
R6289 T11563 T11556 conj P,]
R6290 T11564 T11530 conj <,was
R6291 T11565 T11566 nummod 0.001,]
R6292 T11566 T11564 dobj ],<
R6293 T11567 T11564 punct ),<
R6294 T11568 T11530 punct .,was
R6542 T12114 T12116 amod Increased,production
R6543 T12115 T12116 amod IL-17,production
R6544 T12116 T12148 nsubj production,investigated
R6545 T12117 T12116 prep in,production
R6546 T12118 T12117 pobj PBMC,in
R6547 T12119 T12118 prep of,PBMC
R6548 T12120 T12119 pobj patients,of
R6549 T12121 T12120 prep with,patients
R6550 T12122 T12121 pobj RA,with
R6551 T12123 T12116 prep by,production
R6552 T12124 T12148 advcl anti-CD3,investigated
R6553 T12125 T12124 cc and/or,anti-CD3
R6554 T12126 T12124 conj anti-CD28,anti-CD3
R6555 T12127 T12126 punct ",",anti-CD28
R6556 T12128 T12124 cc and,anti-CD3
R6557 T12129 T12124 conj PHA,anti-CD3
R6558 T12130 T12134 mark Because,known
R6559 T12131 T12134 nsubjpass IL-17,known
R6560 T12132 T12134 auxpass was,known
R6561 T12133 T12134 advmod already,known
R6562 T12134 T12148 advcl known,investigated
R6563 T12135 T12134 prep from,known
R6564 T12136 T12137 amod earlier,reports
R6565 T12137 T12135 pobj reports,from
R6566 T12138 T12140 aux to,produced
R6567 T12139 T12140 auxpass be,produced
R6568 T12140 T12137 acl produced,reports
R6569 T12141 T12140 advmod mainly,produced
R6570 T12142 T12140 agent by,produced
R6571 T12143 T12145 amod activated,cells
R6572 T12144 T12145 compound T,cells
R6573 T12145 T12142 pobj cells,by
R6574 T12146 T12148 punct ",",investigated
R6575 T12147 T12148 nsubj we,investigated
R6576 T12148 T12148 ROOT investigated,investigated
R6577 T12149 T12150 det the,effect
R6578 T12150 T12148 dobj effect,investigated
R6579 T12151 T12150 prep of,effect
R6580 T12152 T12153 amod different,concentrations
R6581 T12153 T12151 pobj concentrations,of
R6582 T12154 T12153 prep of,concentrations
R6583 T12155 T12154 pobj anti-CD3,of
R6584 T12156 T12164 punct (,ml
R6585 T12157 T12162 nummod 1,μg
R6586 T12158 T12159 punct ",",5
R6587 T12159 T12157 prep 5,1
R6588 T12160 T12157 cc and,1
R6589 T12161 T12157 conj 10,1
R6590 T12162 T12164 nmod μg,ml
R6591 T12163 T12164 compound /,ml
R6592 T12164 T12155 appos ml,anti-CD3
R6593 T12165 T12164 punct ),ml
R6594 T12166 T12148 prep as,investigated
R6595 T12167 T12170 det a,activation
R6596 T12168 T12170 compound T,activation
R6597 T12169 T12170 compound cell,activation
R6598 T12170 T12166 pobj activation,as
R6599 T12171 T12170 punct ",",activation
R6600 T12172 T12173 nsubj which,showed
R6601 T12173 T12170 relcl showed,activation
R6602 T12174 T12176 det a,increase
R6603 T12175 T12176 amod dose-dependent,increase
R6604 T12176 T12173 dobj increase,showed
R6605 T12177 T12176 prep in,increase
R6606 T12178 T12179 compound IL-17,levels
R6607 T12179 T12177 pobj levels,in
R6608 T12180 T12179 punct (,levels
R6609 T12181 T12179 appos data,levels
R6610 T12182 T12183 neg not,shown
R6611 T12183 T12181 acl shown,data
R6612 T12184 T12181 punct ),data
R6613 T12185 T12148 punct .,investigated
R6614 T12186 T12193 prep On,chose
R6615 T12187 T12188 det the,basis
R6616 T12188 T12186 pobj basis,On
R6617 T12189 T12188 prep of,basis
R6618 T12190 T12189 pobj this,of
R6619 T12191 T12193 punct ",",chose
R6620 T12192 T12193 nsubj we,chose
R6621 T12193 T12193 ROOT chose,chose
R6622 T12194 T12195 nummod 10,μg
R6623 T12195 T12197 compound μg,ml
R6624 T12196 T12197 compound /,ml
R6625 T12197 T12193 dobj ml,chose
R6626 T12198 T12193 prep as,chose
R6627 T12199 T12201 det a,concentration
R6628 T12200 T12201 compound stimulation,concentration
R6629 T12201 T12198 pobj concentration,as
R6630 T12202 T12201 prep for,concentration
R6631 T12203 T12202 pobj anti-CD3,for
R6632 T12204 T12193 punct .,chose
R6633 T12205 T12206 mark As,shown
R6634 T12206 T12227 advcl shown,produced
R6635 T12207 T12206 prep in,shown
R6636 T12208 T12207 pobj Table,in
R6637 T12209 T12208 nummod 1,Table
R6638 T12210 T12227 punct ",",produced
R6639 T12211 T12215 nmod anti-CD3,production
R6640 T12212 T12213 advmod significantly,upregulated
R6641 T12213 T12215 nmod upregulated,production
R6642 T12214 T12215 compound IL-17,production
R6643 T12215 T12227 nsubj production,produced
R6644 T12216 T12215 prep up,production
R6645 T12217 T12216 prep to,up
R6646 T12218 T12217 pobj 3.7-fold,to
R6647 T12219 T12215 punct ",",production
R6648 T12220 T12215 cc and,production
R6649 T12221 T12222 det the,combination
R6650 T12222 T12215 conj combination,production
R6651 T12223 T12222 prep of,combination
R6652 T12224 T12227 amod anti-CD28,produced
R6653 T12225 T12224 cc and,anti-CD28
R6654 T12226 T12224 conj anti-CD3,anti-CD28
R6655 T12227 T12227 ROOT produced,produced
R6656 T12228 T12229 advmod more,IL-17
R6657 T12229 T12227 dobj IL-17,produced
R6658 T12230 T12235 punct (,fold
R6659 T12231 T12232 advmod approximately,1.3-1
R6660 T12232 T12235 nummod 1.3-1,fold
R6661 T12233 T12235 punct .5,fold
R6662 T12234 T12235 punct -,fold
R6663 T12235 T12229 appos fold,IL-17
R6664 T12236 T12235 punct ),fold
R6665 T12237 T12229 prep than,IL-17
R6666 T12238 T12237 pobj anti-CD3,than
R6667 T12239 T12238 advmod alone,anti-CD3
R6668 T12240 T12227 punct .,produced
R6669 T12241 T12253 advmod Furthermore,increased
R6670 T12242 T12253 punct ",",increased
R6671 T12243 T12244 advmod when,incubated
R6672 T12244 T12253 advcl incubated,increased
R6673 T12245 T12244 prep with,incubated
R6674 T12246 T12247 compound T,cell
R6675 T12247 T12248 compound cell,mitogens
R6676 T12248 T12245 pobj mitogens,with
R6677 T12249 T12250 amod such,as
R6678 T12250 T12248 prep as,mitogens
R6679 T12251 T12250 pobj PHA,as
R6680 T12252 T12253 punct ",",increased
R6681 T12253 T12255 amod increased,production
R6682 T12254 T12255 compound IL-17,production
R6683 T12255 T12256 nsubj production,was
R6684 T12256 T12256 ROOT was,was
R6685 T12257 T12258 advmod more,pronounced
R6686 T12258 T12256 acomp pronounced,was
R6687 T12259 T12258 prep than,pronounced
R6688 T12260 T12259 prep with,than
R6689 T12261 T12260 pobj anti-CD3,with
R6690 T12262 T12261 cc and,anti-CD3
R6691 T12263 T12261 conj anti-CD28,anti-CD3
R6692 T12264 T12263 punct (,anti-CD28
R6693 T12265 T12266 nummod 588,±
R6694 T12266 T12263 appos ±,anti-CD28
R6695 T12267 T12266 nummod 85,±
R6696 T12268 T12267 prep versus,85
R6697 T12269 T12272 nummod 211,pg/ml
R6698 T12270 T12272 nmod ±,pg/ml
R6699 T12271 T12272 nummod 1,pg/ml
R6700 T12272 T12268 pobj pg/ml,versus
R6701 T12273 T12276 punct ;,0.05
R6702 T12274 T12275 compound P,<
R6703 T12275 T12276 compound <,0.05
R6704 T12276 T12256 npadvmod 0.05,was
R6705 T12277 T12276 punct ),0.05
R6706 T12278 T12256 punct .,was
R7021 T12997 T13012 nsubj Regulation,include
R7022 T12998 T12997 prep of,Regulation
R7023 T12999 T13000 amod IL-17,production
R7024 T13000 T12998 pobj production,of
R7025 T13001 T13000 prep in,production
R7026 T13002 T13003 compound RA,PBMC
R7027 T13003 T13001 pobj PBMC,in
R7028 T13004 T12997 prep by,Regulation
R7029 T13005 T13006 amod inflammatory,cytokines
R7030 T13006 T13004 pobj cytokines,by
R7031 T13007 T13006 cc and,cytokines
R7032 T13008 T13006 conj chemokines,cytokines
R7033 T13009 T13012 mark Because,include
R7072 T13048 T13046 pobj cytokines,of
R7073 T13049 T13045 acl released,effects
R7074 T13050 T13049 agent by,released
R7075 T13051 T13052 amod activated,PBMC
R7113 T13089 T13085 punct ),IL-1β
R7114 T13090 T13112 punct ",",were
R7115 T13091 T13109 nmod TNF-α,levels
R7116 T13092 T13094 punct (,ng/ml
R7117 T13093 T13094 nummod 10,ng/ml
R7118 T13094 T13091 appos ng/ml,TNF-α
R7119 T13095 T13094 punct ),ng/ml
R7120 T13096 T13091 punct ",",TNF-α
R7121 T13097 T13109 nmod IL-18,levels
R7122 T13098 T13100 punct (,ng/ml
R7123 T13099 T13100 nummod 10,ng/ml
R7124 T13100 T13097 appos ng/ml,IL-18
R7125 T13101 T13100 punct ),ng/ml
R7126 T13102 T13097 cc or,IL-18
R7127 T13103 T13097 conj TGF-β,IL-18
R7128 T13104 T13106 punct (,ng/ml
R7129 T13105 T13106 nummod 10,ng/ml
R7130 T13106 T13103 appos ng/ml,TGF-β
R7131 T13107 T13106 punct ),ng/ml
R7132 T13108 T13109 det the,levels
R7133 T13109 T13112 nsubj levels,were
R7134 T13110 T13109 prep in,levels
R7135 T13111 T13110 pobj IL-17,in
R7136 T13112 T13068 advcl were,detected
R7137 T13113 T13112 acomp unchanged,were
R7138 T13114 T13112 punct (,were
R7139 T13115 T13112 dobj Fig.,were
R7140 T13116 T13115 nummod 2a,Fig.
R7141 T13117 T13115 punct ),Fig.
R7142 T13118 T13068 punct .,detected
R7143 T13119 T13120 advmod When,treated
R7144 T13120 T13140 advcl treated,observed
R7145 T13121 T13120 prep with,treated
R7146 T13122 T13121 pobj MCP-1,with
R7147 T13123 T13122 punct (,MCP-1
R7148 T13124 T13125 nummod 10,ng/ml
R7149 T13125 T13122 appos ng/ml,MCP-1
R7150 T13126 T13125 punct ),ng/ml
R7151 T13127 T13122 cc or,MCP-1
R7152 T13128 T13122 conj IL-6,MCP-1
R7153 T13129 T13131 punct (,ng/ml
R7154 T13130 T13131 nummod 10,ng/ml
R7155 T13131 T13128 appos ng/ml,IL-6
R7156 T13132 T13131 punct ),ng/ml
R7157 T13133 T13128 punct ",",IL-6
R7158 T13134 T13135 amod significant,upregulations
R7159 T13135 T13122 appos upregulations,MCP-1
R7160 T13136 T13135 prep of,upregulations
R7161 T13137 T13138 compound IL-17,proteins
R7162 T13138 T13136 pobj proteins,of
R7163 T13139 T13140 auxpass were,observed
R7164 T13140 T13140 ROOT observed,observed
R7165 T13141 T13143 punct (,±
R7166 T13142 T13143 nummod 62,±
R7167 T13143 T13151 nmod ±,±
R7168 T13144 T13143 nummod 42,±
R7169 T13145 T13143 cc and,±
R7170 T13146 T13147 nummod 50,±
R7171 T13147 T13143 conj ±,±
R7172 T13148 T13151 nummod 10,±
R7173 T13149 T13148 cc versus,10
R7174 T13150 T13148 conj 31,10
R7175 T13151 T13156 nmod ±,;
R7176 T13152 T13153 nummod 11,pg/ml
R7177 T13153 T13151 appos pg/ml,±
R7178 T13154 T13153 punct ",",pg/ml
R7179 T13155 T13153 conj respectively,pg/ml
R7180 T13156 T13140 punct ;,observed
R7181 T13157 T13158 compound P,<
R7182 T13158 T13159 compound <,0.05
R7183 T13159 T13156 oprd 0.05,;
R7184 T13160 T13159 punct ),0.05
R7185 T13161 T13140 punct ",",observed
R7186 T13162 T13165 mark whereas,observed
R7187 T13163 T13165 nsubjpass none,observed
R7188 T13164 T13165 auxpass was,observed
R7189 T13165 T13140 advcl observed,observed
R7204 T13180 T13182 punct (,ng/ml
R7205 T13181 T13182 nummod 10,ng/ml
R7206 T13182 T13179 appos ng/ml,MIP-1β
R7207 T13183 T13179 punct ),MIP-1β
R7208 T13184 T13185 punct (,Fig.
R7209 T13185 T13173 appos Fig.,MIP-1α
R7210 T13186 T13185 nummod 2b,Fig.
R7211 T13187 T13173 punct ),MIP-1α
R7212 T13188 T13140 punct .,observed
R7635 T14019 T14031 nsubj Inhibition,observed
R7636 T14020 T14019 prep of,Inhibition
R7637 T14021 T14022 compound IL-17,production
R7638 T14022 T14020 pobj production,of
R7639 T14023 T14022 prep by,production
R7640 T14024 T14026 nmod signal,inhibitors
R7641 T14025 T14026 compound transduction,inhibitors
R7642 T14026 T14023 pobj inhibitors,by
R7643 T14027 T14026 cc and,inhibitors
R7644 T14028 T14029 amod anti-rheumatic,drugs
R7645 T14029 T14026 conj drugs,inhibitors
R7646 T14030 T14031 aux Having,observed
R7647 T14031 T14041 ccomp observed,was
R7648 T14032 T14035 det the,production
R7649 T14033 T14035 amod increased,production
R7650 T14034 T14035 compound IL-17,production
R7651 T14035 T14031 dobj production,observed
R7652 T14036 T14035 prep in,production
R7653 T14037 T14038 compound RA,PBMC
R7654 T14038 T14036 pobj PBMC,in
R7655 T14039 T14041 punct ",",was
R7656 T14040 T14041 nsubj it,was
R7657 T14041 T14041 ROOT was,was
R7658 T14042 T14041 acomp important,was
R7659 T14043 T14044 aux to,know
R7660 T14044 T14041 xcomp know,was
R7661 T14045 T14046 nsubj which,signal
R7662 T14046 T14048 nmod signal,pathways
R7663 T14047 T14048 compound transduction,pathways
R7664 T14048 T14050 nsubjpass pathways,involved
R7665 T14049 T14050 auxpass were,involved
R7666 T14050 T14044 ccomp involved,know
R7667 T14051 T14041 punct .,was
R7668 T14052 T14053 mark As,illustrated
R7669 T14053 T14066 advcl illustrated,observed
R7670 T14054 T14053 prep in,illustrated
R7671 T14055 T14054 pobj Fig.,in
R7672 T14056 T14055 nummod 3,Fig.
R7673 T14057 T14055 punct ",",Fig.
R7674 T14058 T14060 det an,decrease
R7675 T14059 T14060 amod significant,decrease
R7676 T14060 T14066 nsubjpass decrease,observed
R7677 T14061 T14060 prep in,decrease
R7678 T14062 T14064 amod anti-CD3-induced,production
R7679 T14063 T14064 compound IL-17,production
R7680 T14064 T14061 pobj production,in
R7681 T14065 T14066 auxpass was,observed
R7682 T14066 T14066 ROOT observed,observed
R7683 T14067 T14068 advmod when,co-incubated
R7684 T14068 T14066 advcl co-incubated,observed
R7685 T14069 T14068 prep with,co-incubated
R7686 T14070 T14071 amod NF-κB,inhibitor
R7687 T14071 T14069 pobj inhibitor,with
R7688 T14072 T14071 punct ",",inhibitor
R7689 T14073 T14071 conj PDTC,inhibitor
R7724 T14108 T14106 pobj inhibitor,as
R7725 T14109 T14108 prep of,inhibitor
R7726 T14110 T14109 pobj PI3K,of
R7727 T14111 T14114 punct ",",inhibited
R7728 T14112 T14114 advmod also,inhibited
R7729 T14113 T14114 advmod markedly,inhibited
R7730 T14114 T14114 ROOT inhibited,inhibited
R7731 T14115 T14118 det the,production
R7732 T14116 T14118 amod anti-CD3-induced,production
R7733 T14117 T14118 compound IL-17,production
R7734 T14118 T14114 dobj production,inhibited
R7803 T14187 T14188 punct (,Fig.
R7804 T14188 T14186 appos Fig.,levels
R7805 T14189 T14188 nummod 3,Fig.
R7806 T14190 T14188 punct ),Fig.
R7807 T14191 T14153 punct .,cyclosporin
R7808 T14192 T14193 aux To,evaluate
R7809 T14193 T14207 advcl evaluate,observed
R7810 T14194 T14195 det the,possibility
R7811 T14195 T14193 dobj possibility,evaluate
R7847 T14231 T14227 prep with,inhibitions
R7848 T14232 T14233 compound chemical,inhibitors
R7849 T14233 T14231 pobj inhibitors,with
R7850 T14234 T14235 punct (,Fig.
R7851 T14235 T14227 appos Fig.,inhibitions
R7852 T14236 T14235 nummod 4a,Fig.
R7853 T14237 T14235 punct ),Fig.
R7854 T14238 T14225 punct .,were
R7855 T14239 T14241 det The,inhibitors
R7856 T14240 T14241 amod other,inhibitors
R7857 T14241 T14248 nsubj inhibitors,showed
R7858 T14242 T14241 prep in,inhibitors
R7859 T14243 T14242 pobj addition,in
R7860 T14244 T14243 prep to,addition
R7861 T14245 T14244 pobj PDTC,to
R7862 T14246 T14245 cc and,PDTC
R7863 T14247 T14245 conj LY294002,PDTC
R7864 T14248 T14248 ROOT showed,showed
R7865 T14249 T14251 det the,pattern
R7866 T14250 T14251 amod same,pattern
R7867 T14251 T14248 dobj pattern,showed
R7868 T14252 T14251 prep of,pattern
R7869 T14253 T14252 pobj inhibition,of
R7870 T14254 T14248 punct .,showed
R7871 T14255 T14256 amod Cytotoxic,effects
R7872 T14256 T14266 nsubj effects,were
R7873 T14257 T14256 prep on,effects
R7874 T14258 T14257 pobj PBMC,on
R7875 T14259 T14256 prep by,effects
R7876 T14260 T14262 det the,inhibitors
R7877 T14261 T14262 compound chemical,inhibitors
R7878 T14262 T14259 pobj inhibitors,by
R7879 T14263 T14262 prep at,inhibitors
R7880 T14264 T14265 amod experimental,concentrations
R7881 T14265 T14263 pobj concentrations,at
R7882 T14266 T14266 ROOT were,were
R7883 T14267 T14266 neg not,were
R7884 T14268 T14266 acomp observed,were
R7885 T14269 T14268 punct (,observed
R7886 T14270 T14272 nmod Fig.,)
R7887 T14271 T14270 nummod 4b,Fig.
R7888 T14272 T14268 punct ),observed
R7889 T14273 T14266 punct .,were
R8059 T14613 T14614 compound IL-17,mRNA
R8060 T14614 T14615 compound mRNA,expression
R8061 T14615 T14615 ROOT expression,expression
R8062 T14616 T14615 prep in,expression
R8063 T14617 T14618 compound RA,PBMC
R8064 T14618 T14616 pobj PBMC,in
R8065 T14619 T14620 aux To,see
R8066 T14620 T14615 advcl see,expression
R8067 T14621 T14627 mark whether,regulated
R8068 T14622 T14624 amod enhanced,production
R8069 T14623 T14624 compound IL-17,production
R8070 T14624 T14627 nsubjpass production,regulated
R8071 T14625 T14627 aux could,regulated
R8072 T14626 T14627 auxpass be,regulated
R8073 T14627 T14620 ccomp regulated,see
R8074 T14628 T14627 prep at,regulated
R8075 T14629 T14631 det a,level
R8076 T14630 T14631 amod transcriptional,level
R8077 T14631 T14628 pobj level,at
R8078 T14632 T14635 punct ",",transcription
R8079 T14633 T14635 amod semi-quantatitive,transcription
R8080 T14634 T14635 compound reverse,transcription
R8081 T14635 T14638 compound transcription,reaction
R8082 T14636 T14638 compound polymerase,reaction
R8083 T14637 T14638 compound chain,reaction
R8084 T14638 T14640 nsubjpass reaction,performed
R8085 T14639 T14640 auxpass was,performed
R8086 T14640 T14627 conj performed,regulated
R8087 T14641 T14615 punct .,expression
R8088 T14642 T14643 nsubj We,observed
R8089 T14643 T14643 ROOT observed,observed
R8090 T14644 T14646 det a,increase
R8091 T14645 T14646 amod dose-dependent,increase
R8092 T14646 T14643 dobj increase,observed
R8093 T14647 T14646 prep in,increase
R8094 T14648 T14649 compound IL-17,mRNA
R8095 T14649 T14650 compound mRNA,transcripts
R8096 T14650 T14647 pobj transcripts,in
R8097 T14651 T14646 prep after,increase
R8098 T14652 T14651 pobj stimulation,after
R8099 T14653 T14652 prep with,stimulation
R8100 T14654 T14653 pobj anti-CD3,with
R8101 T14655 T14658 punct ;,inhibited
R8102 T14656 T14658 nsubjpass this,inhibited
R8103 T14657 T14658 auxpass was,inhibited
R8104 T14658 T14643 ccomp inhibited,observed
R8105 T14659 T14658 agent by,inhibited
R8106 T14660 T14662 det the,inhibitor
R8107 T14661 T14662 compound PI3K,inhibitor
R8108 T14662 T14659 pobj inhibitor,by
R8109 T14663 T14662 appos LY294002,inhibitor
R8110 T14664 T14659 cc and,by
R8111 T14665 T14659 conj by,by
R8112 T14666 T14669 det the,PDTC
R8113 T14667 T14669 amod NF-κB,PDTC
R8114 T14668 T14669 compound inhibitor,PDTC
R8115 T14669 T14665 pobj PDTC,by
R8116 T14670 T14671 punct (,Fig.
R8117 T14671 T14669 appos Fig.,PDTC
R8118 T14672 T14671 nummod 5,Fig.
R8119 T14673 T14669 punct ),PDTC
R8120 T14674 T14643 punct .,observed
R8360 T15245 T15257 nsubj Activation,determine
R8361 T15246 T15245 prep of,Activation
R8362 T15247 T15250 compound PI3K/Akt,pathway
R8363 T15248 T15250 compound signal,pathway
R8364 T15249 T15250 compound transduction,pathway
R8365 T15250 T15246 pobj pathway,of
R8366 T15251 T15250 prep on,pathway
R8367 T15252 T15253 compound IL-17,production
R8368 T15253 T15251 pobj production,on
R8369 T15254 T15245 agent by,Activation
R8370 T15255 T15254 pobj anti-CD3,by
R8371 T15256 T15257 aux To,determine
R8372 T15257 T15267 advcl determine,evaluated
R8373 T15258 T15260 amod downstream,molecules
R8374 T15259 T15260 compound effector,molecules
R8375 T15260 T15257 dobj molecules,determine
R8376 T15261 T15260 prep of,molecules
R8377 T15262 T15264 det the,pathway
R8378 T15263 T15264 compound PI3K,pathway
R8379 T15264 T15261 pobj pathway,of
R8380 T15265 T15267 punct ",",evaluated
R8381 T15266 T15267 nsubj we,evaluated
R8382 T15267 T15267 ROOT evaluated,evaluated
R8383 T15268 T15269 det the,activation
R8384 T15269 T15267 dobj activation,evaluated
R8385 T15270 T15269 prep of,activation
R8386 T15271 T15270 pobj Akt,of
R8387 T15272 T15269 prep by,activation
R8388 T15273 T15274 amod western,blotting
R8389 T15274 T15272 pobj blotting,by
R8390 T15275 T15267 punct .,evaluated
R8391 T15276 T15277 mark As,shown
R8392 T15277 T15311 advcl shown,observed
R8393 T15278 T15277 prep in,shown
R8394 T15279 T15278 pobj Fig.,in
R8395 T15280 T15279 nummod 6,Fig.
R8396 T15281 T15279 punct ",",Fig.
R8397 T15282 T15277 prep at,shown
R8398 T15283 T15284 nummod 10,min
R8399 T15284 T15282 pobj min,at
R8400 T15285 T15284 prep of,min
R8401 T15286 T15285 pobj incubation,of
R8402 T15287 T15284 prep with,min
R8403 T15288 T15287 pobj anti-CD3,with
R8404 T15289 T15288 punct (,anti-CD3
R8405 T15290 T15291 nummod 10,μg
R8406 T15291 T15293 nmod μg,ml
R8407 T15292 T15293 compound /,ml
R8408 T15293 T15288 appos ml,anti-CD3
R8409 T15294 T15293 punct ),ml
R8410 T15295 T15288 cc or,anti-CD3
R8411 T15296 T15288 conj LY294002,anti-CD3
R8412 T15297 T15296 punct (,LY294002
R8413 T15298 T15299 nummod 20,μM
R8414 T15299 T15296 appos μM,LY294002
R8415 T15300 T15296 punct ),LY294002
R8416 T15301 T15284 punct ",",min
R8417 T15302 T15303 det no,difference
R8418 T15303 T15311 nsubjpass difference,observed
R8419 T15304 T15303 prep in,difference
R8420 T15305 T15306 det the,amounts
R8421 T15306 T15304 pobj amounts,in
R8422 T15307 T15306 prep of,amounts
R8423 T15308 T15309 compound phosphorylated,Akt
R8424 T15309 T15307 pobj Akt,of
R8425 T15310 T15311 auxpass was,observed
R8426 T15311 T15311 ROOT observed,observed
R8427 T15312 T15311 punct .,observed
R8428 T15313 T15323 advmod However,increased
R8429 T15314 T15323 punct ",",increased
R8430 T15315 T15323 prep after,increased
R8431 T15316 T15317 nummod 30,min
R8432 T15317 T15315 pobj min,after
R8433 T15318 T15317 prep of,min
R8434 T15319 T15318 pobj incubation,of
R8435 T15320 T15323 punct ",",increased
R8436 T15321 T15322 compound phosphorylated,Akt
R8437 T15322 T15323 nsubj Akt,increased
R8438 T15323 T15323 ROOT increased,increased
R8439 T15324 T15325 punct (,lane
R8440 T15325 T15323 dobj lane,increased
R8441 T15326 T15325 nummod 2,lane
R8442 T15327 T15325 punct ),lane
R8443 T15328 T15323 punct ",",increased
R8444 T15329 T15323 cc and,increased
R8445 T15330 T15331 det the,effect
R8446 T15331 T15340 nsubj effect,reached
R8447 T15332 T15331 prep of,effect
R8448 T15333 T15332 pobj inhibition,of
R8449 T15334 T15331 prep by,effect
R8450 T15335 T15334 pobj LY294002,by
R8451 T15336 T15337 punct (,lane
R8452 T15337 T15335 appos lane,LY294002
R8453 T15338 T15337 nummod 3,lane
R8491 T15376 T15377 amod same,effect
R8492 T15377 T15374 dobj effect,demonstrated
R8493 T15378 T15377 prep on,effect
R8494 T15379 T15380 compound phosphorylated,Akt
R8495 T15380 T15378 pobj Akt,on
R8496 T15381 T15382 mark as,shown
R8497 T15382 T15374 advcl shown,demonstrated
R8498 T15383 T15382 prep with,shown
R8499 T15384 T15383 pobj anti-CD3,with
R8500 T15385 T15384 punct ",",anti-CD3
R8501 T15386 T15387 nsubj which,was
R8502 T15387 T15374 ccomp was,demonstrated
R8503 T15388 T15389 det an,inhibition
R8504 T15389 T15387 attr inhibition,was
R8505 T15390 T15389 prep by,inhibition
R8506 T15391 T15390 pobj wortmannin,by
R8507 T15392 T15391 cc and,wortmannin
R8508 T15393 T15391 conj PDTC,wortmannin
R8509 T15394 T15396 advmod as,as
R8510 T15395 T15396 advmod well,as
R8511 T15396 T15390 cc as,by
R8512 T15397 T15390 conj by,by
R8513 T15398 T15397 pobj LY294002,by
R8514 T15399 T15402 punct (,shown
R8515 T15400 T15402 nsubjpass data,shown
R8516 T15401 T15402 neg not,shown
R8517 T15402 T15387 parataxis shown,was
R8518 T15403 T15402 punct ),shown
R8519 T15404 T15374 punct .,demonstrated
R8888 T16398 T16415 nsubj Activation,investigate
R8889 T16399 T16398 prep of,Activation
R8890 T16400 T16401 det the,NF-κB
R8891 T16401 T16399 pobj NF-κB,of
R8892 T16402 T16401 cc and,NF-κB
R8893 T16403 T16404 amod activator,protein-1
R8894 T16404 T16401 conj protein-1,NF-κB
R8895 T16405 T16406 punct (,AP-1
R8896 T16406 T16404 appos AP-1,protein-1
R8897 T16407 T16406 punct ),AP-1
R8898 T16408 T16398 conj pathway,Activation
R8899 T16409 T16398 prep in,Activation
R8900 T16410 T16413 det the,region
R8901 T16411 T16413 compound IL-17,region
R8902 T16412 T16413 compound promoter,region
R8903 T16413 T16409 pobj region,in
R8904 T16414 T16415 aux To,investigate
R8905 T16415 T16442 advcl investigate,performed
R8906 T16416 T16415 advmod further,investigate
R8907 T16417 T16420 det the,pathway
R8908 T16418 T16420 amod intracellular,pathway
R8909 T16419 T16420 amod signaling,pathway
R8910 T16420 T16415 dobj pathway,investigate
R8911 T16421 T16420 acl activated,pathway
R8912 T16422 T16421 agent by,activated
R8913 T16423 T16430 amod anti-CD3,PHA
R8914 T16424 T16423 cc plus,anti-CD3
R8915 T16425 T16423 conj anti-CD28,anti-CD3
R8916 T16426 T16425 punct ",",anti-CD28
R8917 T16427 T16428 compound concanavalin,A
R8918 T16428 T16425 conj A,anti-CD28
R8919 T16429 T16428 punct ",",A
R8920 T16430 T16422 pobj PHA,by
R8921 T16431 T16430 cc and,PHA
R8922 T16432 T16430 conj IL-15,PHA
R8923 T16433 T16432 punct ",",IL-15
R8924 T16434 T16421 cc and,activated
R8925 T16435 T16421 conj responsible,activated
R8926 T16436 T16435 prep for,responsible
R8927 T16437 T16436 pcomp inducing,for
R8928 T16438 T16439 compound IL-17,expression
R8929 T16439 T16437 dobj expression,inducing
R8930 T16440 T16442 punct ",",performed
R8931 T16441 T16442 nsubj we,performed
R8932 T16442 T16442 ROOT performed,performed
R8933 T16443 T16446 det an,assay
R8934 T16444 T16446 amod electrophoretic,assay
R8935 T16445 T16446 compound mobility-shift,assay
R8936 T16446 T16442 dobj assay,performed
R8937 T16447 T16446 punct (,assay
R8938 T16448 T16446 appos EMSA,assay
R8939 T16449 T16446 punct ),assay
R8940 T16450 T16446 prep of,assay
R8941 T16451 T16453 compound NF-κB,sites
R8942 T16452 T16453 compound recognition,sites
R8943 T16453 T16450 pobj sites,of
R8944 T16454 T16453 prep in,sites
R8945 T16455 T16456 det the,promoters
R8946 T16456 T16454 pobj promoters,in
R8947 T16457 T16456 prep of,promoters
R8948 T16458 T16457 pobj IL-17,of
R8949 T16459 T16442 punct .,performed
R8950 T16460 T16461 mark As,shown
R8951 T16461 T16471 advcl shown,stimulated
R8952 T16462 T16461 prep in,shown
R8953 T16463 T16462 pobj Fig.,in
R8954 T16464 T16463 nummod 7a,Fig.
R8955 T16465 T16463 punct ",",Fig.
R8956 T16466 T16467 amod nuclear,extracts
R8957 T16467 T16471 nsubj extracts,stimulated
R8958 T16468 T16467 prep from,extracts
R8959 T16469 T16470 compound RA,PBMC
R8960 T16470 T16468 pobj PBMC,from
R8961 T16471 T16471 ROOT stimulated,stimulated
R8962 T16472 T16471 prep with,stimulated
R8963 T16473 T16472 pobj anti-CD3,with
R8964 T16474 T16473 cc plus,anti-CD3
R8965 T16475 T16473 conj anti-CD28,anti-CD3
R8966 T16476 T16477 punct (,lane
R8967 T16477 T16473 appos lane,anti-CD3
R8968 T16478 T16477 nummod 2,lane
R8969 T16479 T16471 punct ),stimulated
R8970 T16480 T16471 conj demonstrated,stimulated
R8971 T16481 T16482 amod increased,binding
R8972 T16482 T16480 dobj binding,demonstrated
R8973 T16483 T16482 prep of,binding
R8974 T16484 T16483 pobj NF-κB,of
R8975 T16485 T16484 prep to,NF-κB
R8976 T16486 T16487 compound IL-17,promoters
R8977 T16487 T16485 pobj promoters,to
R8978 T16488 T16480 prep in,demonstrated
R8979 T16489 T16488 pobj comparison,in
R8980 T16490 T16489 prep with,comparison
R8981 T16491 T16490 pobj that,with
R8982 T16492 T16491 prep of,that
R8983 T16493 T16492 pobj controls,of
R8984 T16494 T16495 punct (,lane
R8985 T16495 T16493 parataxis lane,controls
R8986 T16496 T16495 nummod 1,lane
R8987 T16497 T16495 punct ),lane
R8988 T16498 T16471 punct .,stimulated
R8989 T16499 T16501 det A,assay
R8990 T16500 T16501 compound supershift,assay
R8991 T16501 T16502 nsubj assay,demonstrated
R8992 T16502 T16502 ROOT demonstrated,demonstrated
R8993 T16503 T16504 amod shifted,bands
R8994 T16504 T16502 dobj bands,demonstrated
R8995 T16505 T16502 prep in,demonstrated
R8996 T16506 T16510 nummod p65,lanes
R8997 T16507 T16506 cc and,p65
R8998 T16508 T16506 conj p50,p65
R8999 T16509 T16510 punct (,lanes
R9000 T16510 T16505 pobj lanes,in
R9001 T16511 T16510 nummod 3,lanes
R9002 T16512 T16511 cc and,3
R9003 T16513 T16511 conj 4,3
R9004 T16514 T16511 punct ),3
R9005 T16515 T16510 neg not,lanes
R9006 T16516 T16510 prep in,lanes
R9007 T16517 T16516 pobj c-Rel,in
R9008 T16518 T16519 punct (,lane
R9009 T16519 T16517 appos lane,c-Rel
R9010 T16520 T16519 nummod 5,lane
R9011 T16521 T16519 punct ),lane
R9012 T16522 T16502 punct .,demonstrated
R9013 T16523 T16530 prep In,observed
R9014 T16524 T16523 pobj normal,In
R9015 T16525 T16530 nsubjpass PBMC,observed
R9016 T16526 T16528 det the,pattern
R9017 T16527 T16528 amod same,pattern
R9018 T16528 T16525 appos pattern,PBMC
R9019 T16529 T16530 auxpass was,observed
R9020 T16530 T16530 ROOT observed,observed
R9021 T16531 T16530 punct ",",observed
R9022 T16532 T16530 cc but,observed
R9023 T16533 T16534 det the,degree
R9024 T16534 T16542 nsubj degree,was
R9025 T16535 T16534 prep of,degree
R9026 T16536 T16537 amod NF-κB,activation
R9027 T16537 T16535 pobj activation,of
R9028 T16538 T16537 prep by,activation
R9029 T16539 T16542 nsubj anti-CD3,was
R9030 T16540 T16539 cc plus,anti-CD3
R9031 T16541 T16539 conj anti-CD28,anti-CD3
R9032 T16542 T16530 conj was,observed
R9033 T16543 T16544 advmod less,intense
R9034 T16544 T16542 acomp intense,was
R9035 T16545 T16544 prep than,intense
R9036 T16546 T16545 pobj that,than
R9037 T16547 T16546 prep in,that
R9038 T16548 T16549 compound RA,PBMC
R9039 T16549 T16547 pobj PBMC,in
R9040 T16550 T16549 punct (,PBMC
R9041 T16551 T16549 appos Fig.,PBMC
R9042 T16552 T16551 nummod 7b,Fig.
R9043 T16553 T16549 punct ),PBMC
R9044 T16554 T16542 punct .,was
R9045 T16555 T16556 aux To,confirm
R9046 T16556 T16566 advcl confirm,performed
R9047 T16557 T16558 det the,link
R9048 T16558 T16556 dobj link,confirm
R9049 T16559 T16558 prep between,link
R9050 T16560 T16561 amod PI3K,activity
R9051 T16561 T16559 pobj activity,between
R9052 T16562 T16561 cc and,activity
R9053 T16563 T16561 conj NF-κB,activity
R9054 T16564 T16566 punct ",",performed
R9055 T16565 T16566 nsubj we,performed
R9056 T16566 T16566 ROOT performed,performed
R9057 T16567 T16566 dobj EMSA,performed
R9058 T16568 T16569 aux to,determine
R9059 T16569 T16566 advcl determine,performed
R9060 T16570 T16573 det the,activity
R9061 T16571 T16573 amod NF-κB,activity
R9062 T16572 T16573 amod binding,activity
R9063 T16573 T16569 dobj activity,determine
R9064 T16574 T16569 prep after,determine
R9065 T16575 T16574 pobj treatment,after
R9066 T16576 T16575 prep with,treatment
R9067 T16577 T16578 det both,LY294002
R9068 T16578 T16576 pobj LY294002,with
R9069 T16579 T16578 cc and,LY294002
R9070 T16580 T16578 conj PDTC,LY294002
R9071 T16581 T16566 punct .,performed
R9072 T16582 T16583 preconj Both,agents
R9073 T16583 T16584 nsubj agents,block
R9074 T16584 T16584 ROOT block,block
R9075 T16585 T16587 nmod NF-κB,activity
R9076 T16586 T16587 amod DNA-binding,activity
R9077 T16587 T16584 dobj activity,block
R9078 T16588 T16587 prep in,activity
R9079 T16589 T16591 det the,promoter
R9080 T16590 T16591 compound IL-17,promoter
R9081 T16591 T16588 pobj promoter,in
R9082 T16592 T16584 punct (,block
R9083 T16593 T16584 npadvmod Fig.,block
R9084 T16594 T16593 nummod 7c,Fig.
R9085 T16595 T16584 punct ),block
R9086 T16596 T16584 punct .,block
R9087 T16597 T16598 amod Western,blotting
R9088 T16598 T16601 nsubj blotting,showed
R9089 T16599 T16598 prep for,blotting
R9090 T16600 T16601 nsubj IκB-α,showed
R9091 T16601 T16601 ROOT showed,showed
R9092 T16602 T16601 dobj inhibition,showed
R9093 T16603 T16602 prep of,inhibition
R9094 T16604 T16603 pobj degradation,of
R9095 T16605 T16604 prep of,degradation
R9096 T16606 T16605 pobj IκB-α,of
R9097 T16607 T16601 prep by,showed
R9098 T16608 T16607 pobj LY294002,by
R9099 T16609 T16608 cc and,LY294002
R9100 T16610 T16608 conj PDTC,LY294002
R9101 T16611 T16601 prep at,showed
R9102 T16612 T16614 det the,time
R9103 T16613 T16614 amod same,time
R9104 T16614 T16611 pobj time,at
R9105 T16615 T16601 punct (,showed
R9106 T16616 T16601 dobj Fig.,showed
R9107 T16617 T16616 nummod 7c,Fig.
R9108 T16618 T16616 punct ),Fig.
R9109 T16619 T16601 punct .,showed
R9110 T16620 T16628 prep In,activated
R9111 T16621 T16620 pobj contrast,In
R9112 T16622 T16628 punct ",",activated
R9113 T16623 T16625 det the,pathway
R9114 T16624 T16625 compound AP-1,pathway
R9115 T16625 T16628 nsubjpass pathway,activated
R9116 T16626 T16628 auxpass was,activated
R9117 T16627 T16628 neg not,activated
R9118 T16628 T16628 ROOT activated,activated
R9119 T16629 T16628 agent by,activated
R9120 T16630 T16629 pobj stimulation,by
R9121 T16631 T16628 prep with,activated
R9122 T16632 T16636 amod anti-CD3,data
R9123 T16633 T16632 cc plus,anti-CD3
R9124 T16634 T16632 conj anti-CD28,anti-CD3
R9125 T16635 T16636 punct (,data
R9126 T16636 T16631 pobj data,with
R9127 T16637 T16638 neg not,shown
R9128 T16638 T16636 acl shown,data
R9129 T16639 T16636 punct ),data
R9130 T16640 T16628 punct ",",activated
R9131 T16641 T16628 advcl demonstrating,activated
R9132 T16642 T16644 mark that,is
R9133 T16643 T16644 nsubj NF-κB,is
R9134 T16644 T16641 ccomp is,demonstrating
R9135 T16645 T16649 det the,pathway
R9136 T16646 T16649 amod main,pathway
R9137 T16647 T16649 amod intracellular,pathway
R9138 T16648 T16649 amod signaling,pathway
R9139 T16649 T16644 attr pathway,is
R9140 T16650 T16649 prep in,pathway
R9141 T16651 T16652 amod IL-17,production
R9142 T16652 T16650 pobj production,in
R9143 T16653 T16649 prep by,pathway
R9144 T16654 T16655 amod activated,PBMC
R9145 T16655 T16653 pobj PBMC,by
R9146 T16656 T16649 prep from,pathway
R9147 T16657 T16656 pobj patients,from
R9148 T16658 T16649 prep with,pathway
R9149 T16659 T16658 pobj RA,with
R9150 T16660 T16628 punct .,activated
R10760 T20377 T20380 nsubjpass IL-17,described
R10761 T20378 T20380 auxpass was,described
R10762 T20379 T20380 advmod first,described
R10763 T20380 T20380 ROOT described,described
R10764 T20381 T20380 prep as,described
R10765 T20382 T20385 det a,product
R10766 T20383 T20385 compound T,product
R10767 T20384 T20385 compound cell,product
R10768 T20385 T20381 pobj product,as
R10769 T20386 T20385 prep with,product
R10770 T20387 T20388 amod proinflammatory,properties
R10771 T20388 T20386 pobj properties,with
R10772 T20389 T20391 compound [,]
R10773 T20390 T20391 compound "5,22",]
R10774 T20391 T20388 appos ],properties
R10775 T20392 T20380 punct .,described
R10776 T20393 T20395 nsubjpass RA,characterized
R10777 T20394 T20395 auxpass is,characterized
R10778 T20395 T20395 ROOT characterized,characterized
R10779 T20396 T20395 agent by,characterized
R10780 T20397 T20396 pobj hyperplasia,by
R10781 T20398 T20397 prep of,hyperplasia
R10782 T20399 T20401 amod synovial,cells
R10783 T20400 T20401 compound lining,cells
R10784 T20401 T20398 pobj cells,of
R10785 T20402 T20397 cc and,hyperplasia
R10786 T20403 T20405 det an,infiltration
R10787 T20404 T20405 amod intense,infiltration
R10788 T20405 T20397 conj infiltration,hyperplasia
R10789 T20406 T20405 prep by,infiltration
R10790 T20407 T20408 compound mononuclear,cells
R10791 T20408 T20406 pobj cells,by
R10792 T20409 T20411 nmod [,]
R10793 T20410 T20411 nummod 23,]
R10794 T20411 T20408 appos ],cells
R10795 T20412 T20395 punct .,characterized
R10796 T20413 T20414 amod Proinflammatory,cytokines
R10797 T20414 T20420 nsubj cytokines,are
R10798 T20415 T20416 amod such,as
R10799 T20416 T20414 prep as,cytokines
R10800 T20417 T20416 pobj IL-1,as
R10829 T20446 T20443 pobj [,in
R10830 T20447 T20448 nummod 24,]
R10831 T20448 T20446 appos ],[
R10832 T20449 T20420 punct .,are
R10833 T20450 T20454 mark Although,have
R10834 T20451 T20452 compound T,cells
R10835 T20452 T20454 nsubj cells,have
R10836 T20453 T20454 aux may,have
R10837 T20454 T20472 advcl have,limited
R10838 T20455 T20456 det a,role
R10839 T20456 T20454 dobj role,have
R10840 T20457 T20456 prep in,role
R10841 T20458 T20459 det the,augmentation
R10842 T20459 T20457 pobj augmentation,in
R10843 T20460 T20459 prep of,augmentation
R10844 T20461 T20463 amod rheumatoid,inflammation
R10845 T20462 T20463 amod synovial,inflammation
R10846 T20463 T20460 pobj inflammation,of
R10847 T20464 T20459 punct ",",augmentation
R10848 T20465 T20466 det the,lack
R10849 T20466 T20472 nsubj lack,limited
R10850 T20467 T20466 prep of,lack
R10851 T20468 T20470 nmod T,cytokines
R10852 T20469 T20470 amod cell-derived,cytokines
R10868 T20485 T20487 aux has,described
R10869 T20486 T20487 auxpass been,described
R10870 T20487 T20482 advcl described,appealing
R10871 T20488 T20487 prep as,described
R10872 T20489 T20492 det a,cytokine
R10873 T20490 T20492 nmod T,cytokine
R10874 T20491 T20492 amod cell-derived,cytokine
R10875 T20492 T20488 pobj cytokine,as
R10876 T20493 T20492 prep with,cytokine
R10877 T20494 T20495 amod proinflammatory,properties
R10878 T20495 T20493 pobj properties,with
R10879 T20496 T20482 punct .,appealing
R10880 T20497 T20502 prep In,tried
R10881 T20498 T20499 poss our,studies
R10882 T20499 T20497 pobj studies,In
R10883 T20500 T20502 punct ",",tried
R10884 T20501 T20502 nsubj we,tried
R10885 T20502 T20502 ROOT tried,tried
R10886 T20503 T20504 aux to,evaluate
R10887 T20504 T20502 xcomp evaluate,tried
R10888 T20505 T20509 advmod how,regulated
R10889 T20506 T20507 amod IL-17,production
R10890 T20507 T20509 nsubjpass production,regulated
R10891 T20508 T20509 auxpass is,regulated
R10892 T20509 T20504 ccomp regulated,evaluate
R10893 T20510 T20509 prep in,regulated
R10894 T20511 T20512 compound RA,PBMC
R10895 T20512 T20510 pobj PBMC,in
R10896 T20513 T20509 punct ",",regulated
R10897 T20514 T20509 cc and,regulated
R10898 T20515 T20516 det which,signaling
R10899 T20516 T20502 advcl signaling,tried
R10900 T20517 T20516 dobj pathway,signaling
R10901 T20518 T20519 nsubj it,used
R10902 T20519 T20517 relcl used,pathway
R10903 T20520 T20502 punct .,tried
R10904 T20521 T20525 nsubjpass Levels,found
R10905 T20522 T20521 prep of,Levels
R10906 T20523 T20522 pobj IL-17,of
R10907 T20524 T20525 auxpass were,found
R10908 T20525 T20525 ROOT found,found
R10909 T20526 T20527 aux to,be
R10910 T20527 T20525 xcomp be,found
R10911 T20528 T20527 acomp higher,be
R10912 T20529 T20527 prep in,be
R10913 T20530 T20532 nmod RA,fluid
R10914 T20531 T20532 compound synovial,fluid
R10915 T20532 T20529 pobj fluid,in
R10916 T20558 T20545 punct ",",are
R10917 T20533 T20525 prep than,found
R10918 T20559 T20568 mark although,achieved
R10919 T20534 T20533 prep in,than
R10920 T20560 T20562 det the,level
R10921 T20561 T20562 amod highest,level
R10922 T20562 T20568 nsubjpass level,achieved
R10923 T20563 T20562 prep of,level
R10924 T20564 T20565 compound IL-17,production
R10925 T20565 T20563 pobj production,of
R10926 T20535 T20534 pobj OA,in
R10927 T20566 T20568 aux can,achieved
R10928 T20567 T20568 auxpass be,achieved
R10929 T20568 T20545 advcl achieved,are
R10930 T20536 T20537 compound synovial,fluid
R10931 T20569 T20568 agent by,achieved
R10932 T20570 T20573 amod anti-CD3,stimulation
R10933 T20571 T20573 nmod /,stimulation
R10934 T20572 T20573 amod anti-CD28,stimulation
R10935 T20537 T20540 det fluid,]
R10936 T20573 T20569 pobj stimulation,by
R10937 T20574 T20568 prep in,achieved
R10938 T20575 T20576 amod healthy,individuals
R10939 T20538 T20540 nmod [,]
R10940 T20576 T20574 pobj individuals,in
R10941 T20577 T20579 nmod [,]
R10942 T20578 T20579 nummod 25,]
R10943 T20539 T20540 nummod 15,]
R10944 T20579 T20576 appos ],individuals
R10945 T20580 T20545 punct .,are
R10946 T20581 T20603 prep In,increased
R10947 T20540 T20540 ROOT ],]
R10948 T20582 T20583 poss our,experiments
R10949 T20583 T20581 pobj experiments,In
R10950 T20541 T20525 punct .,found
R10951 T20584 T20603 punct ",",increased
R10952 T20585 T20603 nsubj PHA,increased
R10953 T20586 T20585 prep as,PHA
R10954 T20542 T20545 advmod However,are
R10955 T20587 T20586 pobj mitogens,as
R10956 T20588 T20587 punct ",",mitogens
R10957 T20589 T20591 advmod as,as
R10958 T20543 T20545 punct ",",are
R10959 T20590 T20591 advmod well,as
R10960 T20591 T20587 cc as,mitogens
R10961 T20592 T20594 amod anti-CD3,anti-CD28
R10962 T20544 T20545 expl there,are
R10963 T20593 T20594 compound /,anti-CD28
R10964 T20594 T20587 conj anti-CD28,mitogens
R10965 T20595 T20587 prep for,mitogens
R10966 T20545 T20545 ROOT are,are
R10967 T20596 T20595 pcomp signaling,for
R10968 T20597 T20596 prep through,signaling
R10969 T20546 T20547 amod few,data
R10970 T20598 T20601 det the,receptor
R10971 T20599 T20601 compound T,receptor
R10972 T20600 T20601 compound cell,receptor
R10973 T20601 T20597 pobj receptor,through
R10974 T20602 T20603 punct ",",increased
R10975 T20603 T20603 ROOT increased,increased
R10976 T20604 T20605 compound IL-17,production
R10977 T20605 T20603 dobj production,increased
R10978 T20547 T20545 attr data,are
R10979 T20606 T20605 prep from,production
R10980 T20607 T20608 compound RA,PBMC
R10981 T20608 T20606 pobj PBMC,from
R10982 T20548 T20547 amod available,data
R10983 T20609 T20603 prep in,increased
R10984 T20610 T20612 det a,manner
R10985 T20611 T20612 amod dose-dependent,manner
R10986 T20549 T20547 prep on,data
R10987 T20612 T20609 pobj manner,in
R10988 T20550 T20551 det the,agents
R10989 T20613 T20603 punct .,increased
R10990 T20551 T20549 pobj agents,on
R10991 T20614 T20615 nsubj We,found
R10992 T20615 T20615 ROOT found,found
R10993 T20552 T20553 nsubj that,stimulate
R10994 T20616 T20615 punct ",",found
R10995 T20617 T20615 prep by,found
R10996 T20618 T20621 det a,assay
R10997 T20553 T20551 relcl stimulate,agents
R10998 T20619 T20620 compound cell,proliferation
R10999 T20620 T20621 compound proliferation,assay
R11000 T20554 T20555 amod IL-17,production
R11001 T20621 T20617 pobj assay,by
R11002 T20622 T20623 punct (,data
R11003 T20555 T20553 dobj production,stimulate
R11004 T20623 T20615 advcl data,found
R11005 T20624 T20625 neg not,shown
R11006 T20556 T20555 prep in,production
R11007 T20625 T20623 acl shown,data
R11008 T20626 T20623 punct ),data
R11009 T20557 T20556 pobj RA,in
R11010 T20627 T20634 punct ",",be
R11011 T20628 T20634 mark that,be
R11012 T20629 T20630 det this,upregulation
R11013 T20655 T20650 pobj cells,by
R11014 T20630 T20634 nsubj upregulation,be
R11015 T20631 T20630 prep of,upregulation
R11016 T20632 T20631 pobj IL-17,of
R11017 T20633 T20634 aux might,be
R11018 T20656 T20655 punct ",",cells
R11019 T20634 T20623 ccomp be,data
R11020 T20635 T20634 acomp due,be
R11021 T20636 T20635 pcomp to,due
R11022 T20637 T20639 amod increased,activity
R11023 T20638 T20639 amod cellular,activity
R11024 T20639 T20636 pobj activity,to
R11025 T20657 T20658 advmod especially,for
R11026 T20640 T20641 advmod rather,than
R11027 T20641 T20634 cc than,be
R11028 T20642 T20641 prep to,than
R11029 T20643 T20644 amod cellular,proliferation
R11030 T20658 T20650 prep for,by
R11031 T20644 T20642 pobj proliferation,to
R11032 T20645 T20615 punct .,found
R11033 T20646 T20648 nsubjpass IL-17,produced
R11034 T20659 T20660 amod Th1/Th0,cells
R11035 T20647 T20648 auxpass is,produced
R11036 T20648 T20648 ROOT produced,produced
R11037 T20649 T20650 advmod mainly,by
R11038 T20660 T20658 pobj cells,for
R11039 T20650 T20648 agent by,produced
R11040 T20651 T20655 amod activated,cells
R11041 T20661 T20658 punct ",",for
R11042 T20652 T20655 compound CD4,cells
R11043 T20653 T20655 nummod +,cells
R11044 T20654 T20655 compound T,cells
R11045 T20662 T20650 neg not,by
R11046 T20663 T20665 det the,phenotype
R11047 T20664 T20665 amod Th2,phenotype
R11048 T20665 T20648 npadvmod phenotype,produced
R11049 T20752 T20753 compound rheumatoid,synoviocytes
R11050 T20666 T20665 appos [,phenotype
R11051 T20753 T20751 dobj synoviocytes,stimulates
R11052 T20754 T20755 aux to,secrete
R11053 T20667 T20668 nummod 26,]
R11054 T20755 T20751 xcomp secrete,stimulates
R11055 T20756 T20757 amod several,cytokines
R11056 T20757 T20755 dobj cytokines,secrete
R11057 T20668 T20665 conj ],phenotype
R11058 T20758 T20759 amod such,as
R11059 T20759 T20757 prep as,cytokines
R11060 T20669 T20648 punct .,produced
R11061 T20760 T20759 pobj IL-6,as
R11062 T20761 T20760 punct ",",IL-6
R11063 T20762 T20760 conj IL-8,IL-6
R11064 T20670 T20676 advmod However,produced
R11065 T20763 T20762 cc and,IL-8
R11066 T20764 T20765 compound tumor,necrosis
R11067 T20671 T20676 punct ",",produced
R11068 T20765 T20767 compound necrosis,gene
R11069 T20766 T20767 compound factor-stimulated,gene
R11070 T20767 T20755 npadvmod gene,secrete
R11071 T20768 T20767 nummod 6,gene
R11072 T20672 T20676 nsubjpass it,produced
R11073 T20769 T20771 advmod as,as
R11074 T20673 T20676 aux can,produced
R11075 T20770 T20771 advmod well,as
R11076 T20771 T20767 cc as,gene
R11077 T20772 T20773 compound prostaglandin,E2
R11078 T20674 T20676 advmod also,produced
R11079 T20773 T20767 conj E2,gene
R11080 T20774 T20755 prep in,secrete
R11081 T20775 T20778 amod vitro,]
R11082 T20675 T20676 auxpass be,produced
R11083 T20776 T20778 compound [,]
R11084 T20777 T20778 compound "12,28,29",]
R11085 T20676 T20676 ROOT produced,produced
R11086 T20778 T20774 pobj ],in
R11087 T20779 T20751 punct .,stimulates
R11088 T20677 T20676 agent by,produced
R11089 T20780 T20781 expl There,are
R11090 T20781 T20781 ROOT are,are
R11091 T20782 T20784 advmod as,few
R11092 T20678 T20681 nummod CD8,cells
R11093 T20783 T20784 advmod yet,few
R11094 T20784 T20785 nummod few,data
R11095 T20679 T20681 nummod +,cells
R11096 T20785 T20781 attr data,are
R11097 T20786 T20785 amod available,data
R11098 T20787 T20786 prep on,available
R11099 T20680 T20681 compound T,cells
R11100 T20788 T20789 det the,agents
R11101 T20789 T20787 pobj agents,on
R11102 T20790 T20791 nsubj that,stimulate
R11103 T20681 T20677 pobj cells,by
R11104 T20791 T20789 relcl stimulate,agents
R11105 T20792 T20793 amod IL-17,production
R11106 T20793 T20791 dobj production,stimulate
R11107 T20682 T20676 prep via,produced
R11108 T20794 T20793 prep in,production
R11109 T20795 T20794 pobj RA,in
R11110 T20683 T20686 det an,mechanism
R11111 T20796 T20781 punct ",",are
R11112 T20797 T20807 mark although,known
R11113 T20684 T20686 amod IL-23,mechanism
R11114 T20798 T20799 det some,cytokines
R11115 T20799 T20807 nsubjpass cytokines,known
R11116 T20685 T20686 amod triggering,mechanism
R11117 T20800 T20801 punct (,IL-15
R11118 T20801 T20799 appos IL-15,cytokines
R11119 T20802 T20801 cc and,IL-15
R11120 T20686 T20682 pobj mechanism,via
R11121 T20803 T20801 conj IL-23,IL-15
R11122 T20804 T20799 punct ),cytokines
R11123 T20805 T20807 aux have,known
R11124 T20806 T20807 auxpass been,known
R11125 T20807 T20781 advcl known,are
R11126 T20808 T20809 aux to,regulate
R11127 T20809 T20807 xcomp regulate,known
R11128 T20810 T20811 compound IL-17,production
R11129 T20687 T20686 prep in,mechanism
R11130 T20811 T20809 dobj production,regulate
R11131 T20812 T20814 nmod [,]
R11132 T20813 T20814 nummod "13,14",]
R11133 T20688 T20690 amod Gram-negative,infection
R11134 T20814 T20781 attr ],are
R11135 T20815 T20781 punct .,are
R11136 T20816 T20818 nsubj We,investigated
R11137 T20689 T20690 amod pulmonary,infection
R11138 T20817 T20818 advmod therefore,investigated
R11139 T20818 T20818 ROOT investigated,investigated
R11140 T20819 T20828 det the,responding
R11141 T20690 T20687 pobj infection,in
R11142 T20820 T20828 prep in,responding
R11143 T20821 T20822 amod vitro,production
R11144 T20822 T20820 pobj production,in
R11145 T20691 T20693 nmod [,]
R11146 T20823 T20822 prep of,production
R11147 T20824 T20823 pobj IL-17,of
R11148 T20825 T20822 prep in,production
R11149 T20692 T20693 nummod 14,]
R11150 T20826 T20827 compound RA,PBMC
R11151 T20827 T20825 pobj PBMC,in
R11152 T20828 T20818 dobj responding,investigated
R11153 T20693 T20686 appos ],mechanism
R11154 T20829 T20828 prep to,responding
R11155 T20830 T20831 det a,variety
R11156 T20831 T20829 pobj variety,to
R11157 T20694 T20676 punct .,produced
R11158 T20832 T20831 prep of,variety
R11159 T20833 T20832 pobj cytokines/chemokines,of
R11160 T20834 T20833 cc and,cytokines/chemokines
R11161 T20695 T20702 prep In,augmented
R11162 T20835 T20833 conj mitogens,cytokines/chemokines
R11163 T20836 T20838 advmod as,as
R11164 T20696 T20695 pobj addition,In
R11165 T20837 T20838 advmod well,as
R11166 T20838 T20833 cc as,cytokines/chemokines
R11167 T20839 T20841 compound T,receptor
R11168 T20697 T20702 punct ",",augmented
R11169 T20840 T20841 compound cell,receptor
R11170 T20841 T20845 nsubj receptor,ligation
R11171 T20842 T20843 punct (,TCR
R11172 T20843 T20841 appos TCR,receptor
R11173 T20844 T20841 punct ),receptor
R11174 T20845 T20818 ccomp ligation,investigated
R11175 T20846 T20818 advcl using,investigated
R11176 T20698 T20699 compound IL-17,production
R11177 T20847 T20849 amod anti-CD3,anti-CD28
R11178 T20699 T20702 nsubjpass production,augmented
R11179 T20848 T20849 compound /,anti-CD28
R11180 T20700 T20702 auxpass was,augmented
R11181 T20701 T20702 advmod significantly,augmented
R11182 T20702 T20702 ROOT augmented,augmented
R11183 T20849 T20846 dobj anti-CD28,using
R11184 T20703 T20702 agent by,augmented
R11185 T20850 T20818 punct .,investigated
R11186 T20851 T20852 poss Our,studies
R11187 T20852 T20853 nsubj studies,demonstrated
R11188 T20704 T20705 compound T,cells
R11189 T20853 T20853 ROOT demonstrated,demonstrated
R11190 T20854 T20864 mark that,increased
R11191 T20855 T20862 nsubj IL-15,ligation
R11192 T20705 T20703 pobj cells,by
R11193 T20856 T20855 cc and,IL-15
R11194 T20857 T20855 conj MCP-1,IL-15
R11195 T20706 T20705 acl recognizing,cells
R11196 T20858 T20860 advmod as,as
R11197 T20859 T20860 advmod well,as
R11198 T20860 T20857 cc as,MCP-1
R11199 T20707 T20709 compound type,collagen
R11200 T20861 T20862 compound TCR,ligation
R11201 T20862 T20864 nsubj ligation,increased
R11202 T20863 T20864 advmod significantly,increased
R11203 T20708 T20709 compound II,collagen
R11204 T20864 T20853 ccomp increased,demonstrated
R11205 T20865 T20866 det the,production
R11206 T20866 T20864 dobj production,increased
R11207 T20709 T20706 dobj collagen,recognizing
R11208 T20867 T20866 prep of,production
R11209 T20868 T20867 pobj IL-17,of
R11210 T20869 T20864 prep in,increased
R11211 T20710 T20706 prep in,recognizing
R11212 T20870 T20871 compound RA,PBMC
R11213 T20871 T20869 pobj PBMC,in
R11214 T20872 T20853 punct .,demonstrated
R11215 T20711 T20714 det a,model
R11216 T20873 T20873 ROOT Adding,Adding
R11217 T20874 T20873 dobj IL-15,Adding
R11218 T20875 T20874 cc or,IL-15
R11219 T20712 T20714 amod collagen-induced,model
R11220 T20876 T20874 conj MCP-1,IL-15
R11221 T20877 T20873 prep to,Adding
R11222 T20878 T20879 compound TCR,ligation
R11223 T20879 T20880 dep ligation,augmented
R11224 T20880 T20873 nsubj augmented,Adding
R11225 T20881 T20882 amod IL-17,production
R11226 T20713 T20714 compound arthritis,model
R11227 T20882 T20880 dobj production,augmented
R11228 T20883 T20884 advmod more,markedly
R11229 T20884 T20880 advmod markedly,augmented
R11230 T20885 T20880 punct .,augmented
R11231 T20714 T20710 pobj model,in
R11232 T20886 T20910 prep In,affect
R11233 T20887 T20886 pobj contrast,In
R11234 T20888 T20910 punct ",",affect
R11235 T20715 T20717 nmod [,]
R11236 T20889 T20910 nsubj IL-1,affect
R11237 T20890 T20889 cc and,IL-1
R11238 T20891 T20889 conj TNF-α,IL-1
R11239 T20716 T20717 nummod 27,]
R11240 T20892 T20889 punct ",",IL-1
R11241 T20893 T20895 nsubjpass which,known
R11242 T20894 T20895 auxpass are,known
R11243 T20717 T20714 appos ],model
R11244 T20895 T20889 relcl known,IL-1
R11245 T20896 T20897 aux to,have
R11246 T20897 T20895 xcomp have,known
R11247 T20718 T20702 punct .,augmented
R11248 T20898 T20899 amod proinflammatory,properties
R11249 T20899 T20897 dobj properties,have
R11250 T20900 T20897 cc and,have
R11251 T20719 T20721 det A,interaction
R11252 T20901 T20903 aux to,increased
R11253 T20902 T20903 auxpass be,increased
R11254 T20903 T20895 xcomp increased,known
R11255 T20904 T20903 prep in,increased
R11256 T20720 T20721 amod complex,interaction
R11257 T20905 T20906 compound RA,joints
R11258 T20906 T20904 pobj joints,in
R11259 T20907 T20889 punct ",",IL-1
R11260 T20721 T20729 nsubj interaction,produce
R11261 T20908 T20910 aux did,affect
R11262 T20909 T20910 neg not,affect
R11263 T20722 T20721 prep between,interaction
R11264 T20910 T20910 ROOT affect,affect
R11265 T20911 T20912 amod IL-17,production
R11266 T20723 T20722 pobj cells,between
R11267 T20912 T20910 dobj production,affect
R11268 T20724 T20723 prep in,cells
R11269 T20913 T20910 punct .,affect
R11270 T20914 T20915 poss Our,data
R11271 T20725 T20727 amod inflamed,joints
R11272 T20915 T20916 nsubj data,were
R11273 T20916 T20916 ROOT were,were
R11274 T20917 T20916 acomp consistent,were
R11275 T20918 T20917 prep with,consistent
R11276 T20919 T20921 det a,report
R11277 T20920 T20921 amod recent,report
R11278 T20726 T20727 compound RA,joints
R11279 T20921 T20918 pobj report,with
R11280 T20922 T20924 dobj that,triggered
R11281 T20923 T20924 nsubj IL-15,triggered
R11282 T20727 T20724 pobj joints,in
R11283 T20924 T20921 acl triggered,report
R11284 T20925 T20924 prep in,triggered
R11285 T20926 T20928 amod vitro,production
R11286 T20728 T20729 aux might,produce
R11287 T20729 T20729 ROOT produce,produce
R11288 T20927 T20928 compound IL-17,production
R11289 T20928 T20925 pobj production,in
R11290 T20730 T20731 det a,variety
R11291 T20929 T20928 prep in,production
R11292 T20930 T20929 pobj PBMC,in
R11293 T20931 T20916 punct ",",were
R11294 T20731 T20729 dobj variety,produce
R11295 T20932 T20916 cc but,were
R11296 T20933 T20936 nsubj TNF-α,do
R11297 T20934 T20936 aux did,do
R11298 T20732 T20731 prep of,variety
R11299 T20935 T20936 neg not,do
R11300 T20936 T20916 conj do,were
R11301 T20937 T20938 advmod so,[
R11302 T20733 T20734 amod proinflammatory,cytokines
R11303 T20938 T20940 quantmod [,]
R11304 T20939 T20940 nummod 13,]
R11305 T20940 T20936 dobj ],do
R11306 T20734 T20732 pobj cytokines,of
R11307 T20941 T20916 punct .,were
R11308 T20942 T20944 mark Although,were
R11309 T20943 T20944 expl there,were
R11310 T20735 T20734 cc and,cytokines
R11311 T20944 T20957 advcl were,exert
R11312 T20945 T20946 det no,data
R11313 T20736 T20734 conj chemokines,cytokines
R11314 T20737 T20734 punct ",",cytokines
R11315 T20738 T20740 nsubj which,activate
R11316 T20739 T20740 advmod also,activate
R11317 T20946 T20944 attr data,were
R11318 T20947 T20950 mark that,induces
R11319 T20948 T20950 nsubj MCP-1,induces
R11320 T20740 T20734 relcl activate,cytokines
R11321 T20949 T20950 advmod directly,induces
R11322 T20950 T20957 advcl induces,exert
R11323 T20951 T20953 compound T,activation
R11324 T20952 T20953 compound cell,activation
R11325 T20953 T20950 dobj activation,induces
R11326 T20741 T20742 amod other,cells
R11327 T20954 T20957 punct ",",exert
R11328 T20955 T20957 nsubj it,exert
R11329 T20956 T20957 aux might,exert
R11330 T20742 T20740 dobj cells,activate
R11331 T20957 T20957 ROOT exert,exert
R11332 T20958 T20957 dobj effects,exert
R11333 T20743 T20740 prep in,activate
R11334 T20959 T20957 advmod indirectly,exert
R11335 T20960 T20957 prep on,exert
R11336 T20961 T20962 compound T,cells
R11337 T20744 T20745 det the,joints
R11338 T20962 T20960 pobj cells,on
R11339 T20963 T20957 prep through,exert
R11340 T20964 T20965 det the,activation
R11341 T20745 T20743 pobj joints,in
R11342 T20965 T20963 pobj activation,through
R11343 T20966 T20965 prep of,activation
R11344 T20967 T20966 pobj monocytes/macrophages,of
R11345 T20746 T20729 punct .,produce
R11346 T20968 T20967 prep in,monocytes/macrophages
R11347 T20969 T20970 compound PBMC,cultures
R11348 T20970 T20968 pobj cultures,in
R11349 T20747 T20751 prep For,stimulates
R11350 T20971 T20957 punct .,exert
R11351 T20972 T20973 mark As,reported
R11352 T20973 T20989 advcl reported,increases
R11353 T20748 T20747 pobj example,For
R11354 T20974 T20973 prep for,reported
R11355 T20975 T20976 amod normal,individuals
R11356 T20976 T20974 pobj individuals,for
R11357 T20749 T20751 punct ",",stimulates
R11358 T20977 T20979 nmod [,]
R11359 T20978 T20979 nummod 25,]
R11360 T20979 T20989 nsubj ],increases
R11361 T20750 T20751 nsubj IL-17,stimulates
R11362 T20980 T20979 punct ",",]
R11363 T20981 T20983 compound T,activation
R11364 T20982 T20983 compound cell,activation
R11365 T20751 T20751 ROOT stimulates,stimulates
R11366 T20983 T20979 appos activation,]
R11367 T20984 T20983 prep through,activation
R11368 T21043 T21046 nsubjpass pathway,involved
R11369 T20985 T20987 amod anti-CD3,anti-CD28
R11370 T20986 T20987 compound /,anti-CD28
R11371 T20987 T20984 pobj anti-CD28,through
R11372 T21044 T21046 auxpass was,involved
R11373 T20988 T20989 advmod also,increases
R11374 T20989 T20989 ROOT increases,increases
R11375 T20990 T20991 compound IL-17,induction
R11376 T20991 T20989 dobj induction,increases
R11377 T20992 T20991 prep in,induction
R11378 T20993 T20994 compound RA,PBMC
R11379 T20994 T20992 pobj PBMC,in
R11380 T21045 T21046 advmod mainly,involved
R11381 T20995 T20989 punct .,increases
R11382 T20996 T21009 mark Although,documented
R11383 T20997 T20999 det the,pathway
R11384 T21046 T21040 ccomp involved,examined
R11385 T20998 T20999 amod signaling,pathway
R11386 T20999 T21009 nsubjpass pathway,documented
R11387 T21000 T20999 prep for,pathway
R11388 T21001 T21002 det the,induction
R11389 T21047 T21046 prep in,involved
R11390 T21002 T21000 pobj induction,for
R11391 T21003 T21002 prep of,induction
R11392 T21004 T21003 pobj cytokines/chemokines,of
R11393 T21048 T21049 det the,induction
R11394 T21005 T21002 prep by,induction
R11395 T21049 T21047 pobj induction,in
R11396 T21006 T21005 pobj IL-17,by
R11397 T21007 T21009 aux has,documented
R11398 T21050 T21049 prep of,induction
R11399 T21008 T21009 auxpass been,documented
R11400 T21009 T21018 advcl documented,been
R11401 T21010 T21009 advmod widely,documented
R11402 T21051 T21050 pobj IL-17,of
R11403 T21011 T21013 compound [,]
R11404 T21012 T21013 compound "8,30,31",]
R11405 T21052 T21049 prep in,induction
R11406 T21013 T21009 oprd ],documented
R11407 T21014 T21018 punct ",",been
R11408 T21015 T21016 det no,data
R11409 T21053 T21054 compound RA,PBMC
R11410 T21016 T21018 nsubj data,been
R11411 T21017 T21018 aux have,been
R11412 T21018 T21018 ROOT been,been
R11413 T21054 T21052 pobj PBMC,in
R11414 T21019 T21018 acomp available,been
R11415 T21020 T21019 prep on,available
R11416 T21021 T21026 advmod how,regulated
R11417 T21055 T21040 punct .,examined
R11418 T21022 T21023 compound IL-17,production
R11419 T21023 T21026 nsubjpass production,regulated
R11420 T21024 T21026 aux can,regulated
R11421 T21056 T21057 nsubj We,identified
R11422 T21025 T21026 auxpass be,regulated
R11423 T21026 T21020 pcomp regulated,on
R11424 T21027 T21026 agent by,regulated
R11425 T21028 T21030 amod certain,pathways
R11426 T21029 T21030 compound signaling,pathways
R11427 T21030 T21027 pobj pathways,by
R11428 T21057 T21057 ROOT identified,identified
R11429 T21031 T21018 punct .,been
R11430 T21032 T21040 prep By,examined
R11431 T21033 T21032 pcomp using,By
R11432 T21034 T21036 compound signal,inhibitors
R11433 T21058 T21067 mark that,hampered
R11434 T21035 T21036 compound transduction,inhibitors
R11435 T21036 T21033 dobj inhibitors,using
R11436 T21037 T21040 punct ",",examined
R11437 T21059 T21061 amod anti-CD3-induced,production
R11438 T21038 T21040 nsubj we,examined
R11439 T21039 T21040 advmod therefore,examined
R11440 T21040 T21040 ROOT examined,examined
R11441 T21060 T21061 compound IL-17,production
R11442 T21041 T21043 det which,pathway
R11443 T21042 T21043 amod signaling,pathway
R11444 T21061 T21067 nsubjpass production,hampered
R11445 T21062 T21061 prep in,production
R11446 T21063 T21064 compound RA,PBMC
R11447 T21140 T21128 conj stimulate,activated
R11448 T21141 T21140 dobj NF-κB,stimulate
R11449 T21064 T21062 pobj PBMC,in
R11450 T21142 T21140 prep by,stimulate
R11451 T21143 T21144 det a,mechanism
R11452 T21065 T21067 auxpass was,hampered
R11453 T21144 T21142 pobj mechanism,by
R11454 T21145 T21144 acl involving,mechanism
R11455 T21066 T21067 advmod significantly,hampered
R11456 T21067 T21057 ccomp hampered,identified
R11457 T21068 T21067 agent by,hampered
R11458 T21146 T21149 nmod histone,protein
R11459 T21069 T21071 det the,inhibitor
R11460 T21147 T21149 nmod acetylase,protein
R11461 T21148 T21149 compound p300/CREB-binding,protein
R11462 T21149 T21145 dobj protein,involving
R11463 T21070 T21071 compound PI3K,inhibitor
R11464 T21150 T21152 nmod [,]
R11465 T21151 T21152 nummod 33,]
R11466 T21071 T21068 pobj inhibitor,by
R11467 T21152 T21149 appos ],protein
R11468 T21153 T21140 punct .,stimulate
R11469 T21154 T21155 poss Our,results
R11470 T21072 T21071 appos LY294002,inhibitor
R11471 T21155 T21156 nsubj results,revealed
R11472 T21156 T21156 ROOT revealed,revealed
R11473 T21157 T21163 mark that,affected
R11474 T21158 T21160 compound p38,activation
R11475 T21159 T21160 compound MAPK,activation
R11476 T21160 T21163 nsubjpass activation,affected
R11477 T21073 T21072 cc and,LY294002
R11478 T21161 T21163 auxpass was,affected
R11479 T21074 T21076 det the,inhibitor
R11480 T21162 T21163 neg not,affected
R11481 T21163 T21156 ccomp affected,revealed
R11482 T21075 T21076 compound NF-κB,inhibitor
R11483 T21164 T21163 agent by,affected
R11484 T21165 T21164 pobj LY294002,by
R11485 T21166 T21163 punct ",",affected
R11486 T21076 T21078 dep inhibitor,to
R11487 T21167 T21172 mark whereas,decreased
R11488 T21168 T21170 nmod NF-κB,activity
R11489 T21169 T21170 amod binding,activity
R11490 T21077 T21076 appos PDTC,inhibitor
R11491 T21170 T21172 nsubjpass activity,decreased
R11492 T21171 T21172 auxpass was,decreased
R11493 T21078 T21067 prep to,hampered
R11494 T21172 T21163 advcl decreased,affected
R11495 T21173 T21172 agent by,decreased
R11496 T21174 T21173 pobj LY294002,by
R11497 T21079 T21080 amod comparable,levels
R11498 T21175 T21174 punct ",",LY294002
R11499 T21176 T21177 nsubj which,provided
R11500 T21080 T21078 pobj levels,to
R11501 T21177 T21174 relcl provided,LY294002
R11502 T21178 T21179 det the,evidence
R11503 T21179 T21177 dobj evidence,provided
R11504 T21081 T21080 prep of,levels
R11505 T21180 T21179 prep for,evidence
R11506 T21181 T21184 det a,pathway
R11507 T21082 T21083 amod basal,production
R11508 T21182 T21184 amod p38,pathway
R11509 T21183 T21184 compound MAPK,pathway
R11510 T21184 T21180 pobj pathway,for
R11511 T21185 T21184 amod independent,pathway
R11512 T21083 T21081 pobj production,of
R11513 T21186 T21185 prep of,independent
R11514 T21187 T21188 nummod PI3K,activation
R11515 T21084 T21067 prep without,hampered
R11516 T21188 T21186 pobj activation,of
R11517 T21189 T21156 punct .,revealed
R11518 T21190 T21192 det The,relationship
R11519 T21085 T21084 pobj stimulation,without
R11520 T21191 T21192 amod direct,relationship
R11521 T21192 T21200 nsubj relationship,needs
R11522 T21193 T21192 prep between,relationship
R11523 T21086 T21057 punct .,identified
R11524 T21194 T21193 pobj p38,between
R11525 T21195 T21194 cc and,p38
R11526 T21196 T21194 conj NF-κB,p38
R11527 T21197 T21196 prep for,NF-κB
R11528 T21198 T21199 compound IL-17,production
R11529 T21199 T21197 pobj production,for
R11530 T21087 T21089 nsubj We,found
R11531 T21200 T21200 ROOT needs,needs
R11532 T21201 T21203 aux to,studied
R11533 T21088 T21089 advmod also,found
R11534 T21202 T21203 auxpass be,studied
R11535 T21203 T21200 xcomp studied,needs
R11536 T21204 T21203 prep in,studied
R11537 T21205 T21206 amod future,experiments
R11538 T21089 T21089 ROOT found,found
R11539 T21206 T21204 pobj experiments,in
R11540 T21207 T21200 punct .,needs
R11541 T21090 T21094 mark that,was
R11542 T21208 T21209 det The,search
R11543 T21209 T21216 nsubj search,seemed
R11544 T21210 T21209 prep for,search
R11545 T21091 T21093 amod anti-CD3-induced,production
R11546 T21211 T21213 det a,pathway
R11547 T21212 T21213 amod downstream,pathway
R11548 T21213 T21210 pobj pathway,for
R11549 T21092 T21093 compound IL-17,production
R11550 T21214 T21213 prep of,pathway
R11551 T21215 T21214 pobj PI3K,of
R11552 T21216 T21216 ROOT seemed,seemed
R11553 T21093 T21094 nsubj production,was
R11554 T21217 T21218 aux to,have
R11555 T21218 T21216 xcomp have,seemed
R11556 T21094 T21095 auxpass was,downregulated
R11557 T21219 T21221 det a,response
R11558 T21220 T21221 amod maximal,response
R11559 T21221 T21218 dobj response,have
R11560 T21095 T21089 ccomp downregulated,found
R11561 T21222 T21221 prep of,response
R11562 T21223 T21224 compound Akt,activation
R11563 T21096 T21095 agent by,downregulated
R11564 T21224 T21222 pobj activation,of
R11565 T21225 T21218 prep at,have
R11566 T21226 T21227 nummod 1,hour
R11567 T21227 T21225 pobj hour,at
R11568 T21097 T21098 det the,addition
R11569 T21228 T21227 cc and,hour
R11570 T21229 T21231 det a,loss
R11571 T21098 T21096 pobj addition,by
R11572 T21230 T21231 amod gradual,loss
R11573 T21231 T21227 conj loss,hour
R11574 T21232 T21231 prep of,loss
R11575 T21233 T21232 pobj activity,of
R11576 T21234 T21231 prep at,loss
R11577 T21235 T21236 nummod 2,hours
R11578 T21099 T21098 prep of,addition
R11579 T21236 T21234 pobj hours,at
R11580 T21100 T21099 pobj SB203580,of
R11581 T21101 T21100 punct ",",SB203580
R11582 T21102 T21105 det a,inhibitor
R11583 T21237 T21216 punct .,seemed
R11584 T21238 T21239 det The,fact
R11585 T21103 T21105 amod p38,inhibitor
R11586 T21239 T21239 ROOT fact,fact
R11587 T21104 T21105 compound MAPK,inhibitor
R11588 T21240 T21242 mark that,is
R11589 T21241 T21242 nsubj Akt,is
R11590 T21105 T21100 appos inhibitor,SB203580
R11591 T21106 T21089 punct .,found
R11592 T21107 T21108 nsubj It,is
R11593 T21242 T21239 acl is,fact
R11594 T21108 T21108 ROOT is,is
R11595 T21243 T21242 acomp phosphorylated,is
R11596 T21244 T21243 prep upon,phosphorylated
R11597 T21245 T21246 amod anti-CD3,stimulation
R11598 T21109 T21108 acomp interesting,is
R11599 T21246 T21244 pobj stimulation,upon
R11600 T21247 T21243 auxpass suggests,phosphorylated
R11601 T21248 T21250 det the,involvement
R11602 T21110 T21115 mark that,supports
R11603 T21249 T21250 amod possible,involvement
R11604 T21250 T21247 dobj involvement,suggests
R11605 T21111 T21112 det a,series
R11606 T21251 T21250 prep of,involvement
R11607 T21252 T21251 pobj PI3K,of
R11608 T21253 T21250 prep in,involvement
R11609 T21254 T21255 det the,induction
R11610 T21112 T21115 nsubj series,supports
R11611 T21255 T21253 pobj induction,in
R11612 T21256 T21255 prep of,induction
R11613 T21257 T21256 pobj IL-17,of
R11614 T21113 T21112 prep of,series
R11615 T21258 T21255 prep in,induction
R11616 T21259 T21258 pobj RA,in
R11617 T21260 T21239 punct .,fact
R11618 T21114 T21113 pobj evidence,of
R11619 T21261 T21284 prep In,is
R11620 T21262 T21261 pobj view,In
R11621 T21263 T21262 prep of,view
R11622 T21115 T21108 ccomp supports,is
R11623 T21264 T21265 det the,fact
R11624 T21265 T21263 pobj fact,of
R11625 T21116 T21115 dobj crosstalk,supports
R11626 T21266 T21270 mark that,activated
R11627 T21267 T21270 nsubjpass NF-κB,activated
R11628 T21268 T21270 auxpass was,activated
R11629 T21269 T21270 advmod also,activated
R11630 T21270 T21265 acl activated,fact
R11631 T21271 T21270 agent by,activated
R11632 T21272 T21274 amod anti-CD3,anti-CD28
R11633 T21117 T21116 prep between,crosstalk
R11634 T21273 T21274 compound /,anti-CD28
R11635 T21274 T21271 pobj anti-CD28,by
R11636 T21275 T21274 punct ",",anti-CD28
R11637 T21276 T21274 conj IL-15,anti-CD28
R11638 T21118 T21117 pobj NF-κB,between
R11639 T21277 T21276 cc or,IL-15
R11640 T21119 T21118 cc and,NF-κB
R11641 T21120 T21118 conj p38,NF-κB
R11642 T21121 T21108 punct .,is
R11643 T21278 T21276 conj mitogens,IL-15
R11644 T21279 T21278 prep in,mitogens
R11645 T21280 T21281 poss our,experiments
R11646 T21281 T21279 pobj experiments,in
R11647 T21122 T21128 prep In,activated
R11648 T21282 T21284 punct ",",is
R11649 T21283 T21284 nsubj it,is
R11650 T21123 T21122 pobj myocytes,In
R11651 T21284 T21284 ROOT is,is
R11652 T21285 T21286 advmod most,likely
R11653 T21286 T21284 acomp likely,is
R11654 T21124 T21128 punct ",",activated
R11655 T21287 T21294 mark that,involved
R11656 T21288 T21290 det the,pathway
R11657 T21289 T21290 compound NF-κB,pathway
R11658 T21290 T21294 nsubjpass pathway,involved
R11659 T21125 T21126 compound IκB,kinase-β
R11660 T21291 T21294 auxpass is,involved
R11661 T21292 T21294 advmod also,involved
R11662 T21293 T21294 advmod actively,involved
R11663 T21126 T21128 nsubjpass kinase-β,activated
R11664 T21294 T21286 ccomp involved,likely
R11665 T21295 T21294 prep in,involved
R11666 T21296 T21297 det the,induction
R11667 T21127 T21128 auxpass is,activated
R11668 T21297 T21295 pobj induction,in
R11669 T21298 T21297 prep of,induction
R11670 T21299 T21298 pobj IL-17,of
R11671 T21128 T21128 ROOT activated,activated
R11672 T21300 T21297 prep in,induction
R11673 T21301 T21302 compound RA,PBMC
R11674 T21302 T21300 pobj PBMC,in
R11675 T21129 T21128 agent by,activated
R11676 T21303 T21284 punct .,is
R11677 T21304 T21322 prep In,activated
R11678 T21305 T21304 pobj contrast,In
R11679 T21306 T21322 punct ",",activated
R11680 T21307 T21311 det the,pathway
R11681 T21308 T21311 compound AP-1,pathway
R11682 T21130 T21133 nummod p38,]
R11683 T21309 T21311 compound signal,pathway
R11684 T21310 T21311 compound transduction,pathway
R11685 T21311 T21322 nsubjpass pathway,activated
R11686 T21312 T21311 punct ",",pathway
R11687 T21131 T21133 nmod [,]
R11688 T21313 T21316 det another,pathway
R11689 T21314 T21316 amod important,pathway
R11690 T21132 T21133 nummod 32,]
R11691 T21315 T21316 amod signaling,pathway
R11692 T21316 T21311 conj pathway,pathway
R11693 T21317 T21316 prep for,pathway
R11694 T21133 T21129 pobj ],by
R11695 T21318 T21317 pobj cytokines/chemokines,for
R11696 T21134 T21128 punct ",",activated
R11697 T21135 T21128 cc and,activated
R11698 T21319 T21322 punct ",",activated
R11699 T21320 T21322 auxpass was,activated
R11700 T21136 T21138 det the,p38
R11701 T21321 T21322 neg not,activated
R11702 T21322 T21322 ROOT activated,activated
R11703 T21323 T21322 prep in,activated
R11704 T21137 T21138 amod activated,p38
R11705 T21324 T21325 poss our,experiments
R11706 T21325 T21323 pobj experiments,in
R11707 T21326 T21325 punct (,experiments
R11708 T21138 T21140 nsubj p38,stimulate
R11709 T21327 T21329 nsubj data,shown
R11710 T21328 T21329 neg not,shown
R11711 T21139 T21140 aux can,stimulate
R11712 T21329 T21322 conj shown,activated
R11713 T21330 T21329 punct ),shown
R11714 T21331 T21322 punct .,activated
R11715 T21332 T21345 mark Although,reported
R11716 T21334 T21333 cc and,PI3K
R11717 T21333 T21345 nsubjpass PI3K,reported
R11718 T21335 T21337 poss its,kinase
R11719 T21431 T21432 nsubj IL-17,signaling
R11720 T21432 T21434 nsubj signaling,is
R11721 T21433 T21434 nsubj pathway,is
R11722 T21336 T21337 amod downstream,kinase
R11723 T21434 T21429 ccomp is,understanding
R11724 T21435 T21437 det an,element
R11725 T21436 T21437 amod important,element
R11726 T21437 T21434 attr element,is
R11727 T21438 T21437 prep of,element
R11728 T21439 T21438 pcomp developing,of
R11729 T21440 T21442 amod new,therapies
R11730 T21337 T21338 compound kinase,Akt
R11731 T21441 T21442 amod targeted,therapies
R11732 T21442 T21439 dobj therapies,developing
R11733 T21443 T21439 prep in,developing
R11734 T21444 T21443 pobj RA,in
R11735 T21338 T21333 conj Akt,PI3K
R11736 T21445 T21410 punct .,Considering
R11737 T21339 T21333 prep in,PI3K
R11738 T21340 T21339 pobj association,in
R11739 T21341 T21340 prep with,association
R11740 T21342 T21341 pobj NF-κB,with
R11741 T21343 T21345 aux have,reported
R11742 T21344 T21345 auxpass been,reported
R11743 T21345 T21363 advcl reported,lacking
R11744 T21346 T21347 aux to,deliver
R11745 T21347 T21345 xcomp deliver,reported
R11746 T21348 T21349 amod activating,signals
R11747 T21349 T21347 dobj signals,deliver
R11750 T21350 T21347 prep in,deliver
R11752 T21351 T21353 amod many,types
R11753 T21352 T21353 compound cell,types
R11754 T21353 T21350 pobj types,in
R11755 T21354 T21363 punct ",",lacking
R11756 T21355 T21356 det the,data
R11757 T21356 T21363 nsubj data,lacking
R11759 T21357 T21356 prep on,data
R11761 T21358 T21359 det the,signal
R11762 T21359 T21357 pobj signal,on
R11764 T21360 T21359 acl inducing,signal
R11766 T21361 T21360 dobj IL-17,inducing
R11767 T21362 T21363 aux are,lacking
R11770 T21363 T21363 ROOT lacking,lacking
R11772 T21364 T21363 punct .,lacking
R11775 T21365 T21366 poss Our,data
R11780 T21366 T21368 nsubj data,demonstrated
R11781 T21367 T21368 advmod clearly,demonstrated
R11783 T21368 T21368 ROOT demonstrated,demonstrated
R11786 T21369 T21376 mark that,be
R11789 T21370 T21376 nsubj PI3K/Akt,be
R11793 T21371 T21370 cc and,PI3K/Akt
R11794 T21372 T21374 amod resultant,activation
R11795 T21373 T21374 compound NF-κB,activation
R11797 T21374 T21370 conj activation,PI3K/Akt
R11800 T21375 T21376 aux could,be
R11811 T21376 T21368 ccomp be,demonstrated
R11813 T21377 T21379 det an,arbitrator
R11814 T21378 T21379 amod important,arbitrator
R11817 T21379 T21376 attr arbitrator,be
R11821 T21380 T21379 prep of,arbitrator
R11822 T21381 T21382 det the,upregulation
R11823 T21382 T21380 pobj upregulation,of
R11828 T21383 T21382 prep of,upregulation
R11831 T21384 T21383 pobj IL-17,of
R11833 T21385 T21382 prep in,upregulation
R11835 T21386 T21385 pobj RA,in
R11840 T21387 T21379 punct ",",arbitrator
R11841 T21388 T21379 prep on,arbitrator
R11843 T21389 T21390 det the,basis
R11844 T21390 T21388 pobj basis,on
R11845 T21391 T21390 prep of,basis
R11846 T21392 T21393 poss our,experiments
R11848 T21393 T21391 pobj experiments,of
R11849 T21394 T21393 acl showing,experiments
R11853 T21395 T21396 amod simultaneous,blocking
R11855 T21396 T21394 dobj blocking,showing
R11858 T21397 T21396 prep of,blocking
R11860 T21398 T21400 amod NF-κB,activity
R11862 T21399 T21400 amod binding,activity
R11864 T21400 T21397 pobj activity,of
R11866 T21401 T21400 prep in,activity
R11868 T21402 T21404 det the,promoter
R11871 T21403 T21404 compound IL-17,promoter
R11872 T21404 T21401 pobj promoter,in
R11874 T21405 T21396 prep by,blocking
R11883 T21406 T21405 pobj PDTC,by
R11884 T21407 T21406 cc and,PDTC
R11887 T21408 T21406 conj LY294002,PDTC
R11890 T21409 T21368 punct .,demonstrated
R11893 T21410 T21410 ROOT Considering,Considering
R11895 T21411 T21413 poss its,activities
R11898 T21412 T21413 amod proinflammatory,activities
R11900 T21413 T21410 dobj activities,Considering
R11902 T21414 T21413 cc and,activities
R11903 T21415 T21416 amod successful,induction
R11908 T21416 T21413 conj induction,activities
R11914 T21417 T21416 prep of,induction
R11916 T21418 T21417 pobj anti-IL-17,of
R11917 T21419 T21418 prep for,anti-IL-17
R11918 T21420 T21419 pcomp ameliorating,for
R11919 T21421 T21420 dobj arthritis,ameliorating
R11920 T21422 T21420 prep in,ameliorating
R11921 T21423 T21424 compound animal,models
R11922 T21424 T21422 pobj models,in
R11923 T21425 T21427 compound [,]
R11926 T21426 T21427 compound "2,6,34-36",]
R11927 T21427 T21424 appos ],models
R11928 T21428 T21427 punct ",",]
R11929 T21429 T21420 conj understanding,ameliorating
R11930 T21430 T21431 det the,IL-17
R12228 T22443 T22445 nsubj We,detected
R12229 T22444 T22445 aux have,detected
R12230 T22445 T22445 ROOT detected,detected
R12231 T22446 T22449 det a,production
R12232 T22447 T22448 advmod more,pronounced
R12233 T22448 T22449 amod pronounced,production
R12234 T22449 T22445 dobj production,detected
R12235 T22450 T22449 prep of,production
R12236 T22451 T22450 pobj IL-17,of
R12237 T22452 T22449 prep from,production
R12238 T22453 T22454 compound RA,PBMC
R12239 T22454 T22452 pobj PBMC,from
R12240 T22455 T22449 prep in,production
R12241 T22456 T22455 pobj response,in
R12242 T22457 T22456 prep to,response
R12243 T22458 T22457 pobj IL-15,to
R12244 T22459 T22458 cc and,IL-15
R12245 T22460 T22458 conj MCP-1,IL-15
R12246 T22461 T22463 advmod as,as
R12247 T22462 T22463 advmod well,as
R12248 T22463 T22456 cc as,response
R12249 T22464 T22456 conj stimulation,response
R12250 T22465 T22449 prep by,production
R12251 T22466 T22468 amod anti-CD3,anti-CD28
R12252 T22467 T22468 compound /,anti-CD28
R12253 T22468 T22465 pobj anti-CD28,by
R12254 T22469 T22445 punct .,detected
R12255 T22470 T22473 nsubj We,shown
R12256 T22471 T22473 aux have,shown
R12257 T22472 T22473 advmod also,shown
R12258 T22473 T22473 ROOT shown,shown
R12259 T22474 T22487 mark that,be
R12260 T22475 T22487 nsubj upregulation,be
R12261 T22476 T22475 prep of,upregulation
R12262 T22477 T22476 pobj IL-17,of
R12263 T22478 T22475 prep by,upregulation
R12264 T22479 T22481 amod activated,cells
R12265 T22480 T22481 compound T,cells
R12266 T22481 T22478 pobj cells,by
R12267 T22482 T22475 prep in,upregulation
R12268 T22483 T22482 pobj patients,in
R12269 T22484 T22475 prep with,upregulation
R12270 T22485 T22484 pobj RA,with
R12271 T22486 T22487 aux could,be
R12272 T22487 T22473 ccomp be,shown
R12273 T22488 T22489 det the,result
R12274 T22489 T22487 attr result,be
R12275 T22490 T22489 prep of,result
R12276 T22491 T22490 pobj activation,of
R12277 T22492 T22487 prep via,be
R12278 T22493 T22495 det the,pathway
R12279 T22494 T22495 amod PI3K/Akt,pathway
R12280 T22495 T22492 pobj pathway,via
R12281 T22496 T22495 prep with,pathway
R12282 T22497 T22499 amod resultant,activation
R12283 T22498 T22499 compound NF-κB,activation
R12284 T22499 T22496 pobj activation,with
R12285 T22500 T22473 punct .,shown
R12286 T22501 T22502 poss Our,data
R12287 T22502 T22503 nsubj data,provide
R12288 T22503 T22503 ROOT provide,provide
R12289 T22504 T22503 dobj insights,provide
R12290 T22505 T22504 prep into,insights
R12291 T22506 T22507 amod cellular,mechanisms
R12292 T22507 T22505 pobj mechanisms,into
R12293 T22508 T22507 prep of,mechanisms
R12294 T22509 T22510 det the,regulation
R12295 T22510 T22508 pobj regulation,of
R12296 T22511 T22510 prep of,regulation
R12297 T22512 T22513 amod IL-17,production
R12298 T22513 T22511 pobj production,of
R12299 T22514 T22513 prep in,production
R12300 T22515 T22514 pobj RA,in
R12301 T22516 T22503 punct ",",provide
R12302 T22517 T22503 cc and,provide
R12303 T22518 T22503 conj highlight,provide
R12304 T22519 T22520 det the,role
R12305 T22520 T22518 dobj role,highlight
R12306 T22521 T22520 prep of,role
R12307 T22522 T22523 compound T,cells
R12308 T22523 T22521 pobj cells,of
R12309 T22524 T22523 punct ",",cells
R12310 T22525 T22529 nsubj which,neglected
R12311 T22526 T22529 aux has,neglected
R12312 T22527 T22529 advmod hitherto,neglected
R12313 T22528 T22529 auxpass been,neglected
R12314 T22529 T22523 relcl neglected,cells
R12315 T22530 T22529 prep in,neglected
R12316 T22531 T22532 compound RA,pathogenesis
R12317 T22532 T22530 pobj pathogenesis,in
R12318 T22533 T22503 punct .,provide
R12319 T22534 T22535 advmod Together,with
R12320 T22535 T22550 prep with,added
R12321 T22536 T22537 amod recent,data
R12322 T22537 T22535 pobj data,with
R12323 T22538 T22537 prep on,data
R12324 T22539 T22541 det the,introduction
R12325 T22540 T22541 amod successful,introduction
R12326 T22541 T22538 pobj introduction,on
R12327 T22542 T22541 prep of,introduction
R12328 T22543 T22542 pobj anti-IL-17,of
R12329 T22544 T22541 prep in,introduction
R12330 T22545 T22544 pobj RA,in
R12331 T22546 T22550 punct ",",added
R12332 T22547 T22548 poss our,results
R12333 T22548 T22550 nsubj results,added
R12334 T22549 T22550 aux have,added
R12335 T22550 T22550 ROOT added,added
R12336 T22551 T22550 dobj information,added
R12337 T22552 T22550 prep for,added
R12338 T22553 T22556 det the,targeting
R12339 T22554 T22556 amod future,targeting
R12340 T22555 T22556 amod molecular,targeting
R12341 T22556 T22552 pobj targeting,for
R12342 T22557 T22556 prep of,targeting
R12343 T22558 T22560 amod new,applications
R12344 T22559 T22560 amod therapeutic,applications
R12345 T22560 T22557 pobj applications,of
R12346 T22561 T22560 prep in,applications
R12347 T22562 T22561 pobj RA,in
R12348 T22563 T22550 punct .,added
R4416 T8065 T8066 nummod 10,pg/ml
R4417 T8066 T8064 attr pg/ml,was
R4418 T8067 T8064 punct .,was
R4419 T8068 T8070 amod Recombinant,IL-17
R4420 T8069 T8070 amod human,IL-17
R4421 T8070 T8071 nsubj IL-17,diluted
R4422 T8071 T8076 nsubjpass diluted,used
R4423 T8072 T8071 prep in,diluted
R4424 T8073 T8074 compound culture,medium
R4425 T8074 T8072 pobj medium,in
R4426 T8075 T8076 auxpass was,used
R4427 T8076 T8076 ROOT used,used
R4428 T8077 T8076 prep as,used
R4429 T8078 T8080 det a,standard
R4430 T8079 T8080 compound calibration,standard
R4431 T8080 T8077 pobj standard,as
R4432 T8081 T8076 punct ",",used
R4433 T8082 T8076 advcl ranging,used
R4434 T8083 T8082 prep from,ranging
R4435 T8084 T8083 pobj 10,from
R4436 T8085 T8083 prep to,from
R4437 T8086 T8087 det 2000,pg/ml
R4438 T8087 T8085 pobj pg/ml,to
R4439 T8088 T8076 punct .,used
R4440 T8089 T8091 det A,curve
R4441 T8090 T8091 amod standard,curve
R4442 T8091 T8093 nsubjpass curve,drawn
R4443 T8092 T8093 auxpass was,drawn
R4444 T8093 T8093 ROOT drawn,drawn
R4445 T8094 T8093 agent by,drawn
R4446 T8095 T8094 pcomp plotting,by
R4447 T8096 T8097 amod optical,density
R4448 T8097 T8095 dobj density,plotting
R4449 T8098 T8097 prep against,density
R4450 T8099 T8100 det the,log
R4451 T8100 T8098 pobj log,against
R4452 T8101 T8100 prep of,log
R4453 T8102 T8103 det the,concentration
R4458 T8107 T8093 punct ",",drawn
R4459 T8108 T8093 cc and,drawn
R4460 T8109 T8093 conj used,drawn
R4461 T8110 T8109 prep for,used
R4462 T8111 T8110 pobj determination,for
R4463 T8112 T8111 prep of,determination
R4464 T8113 T8112 pobj IL-17,of
R4465 T8114 T8111 prep in,determination
R4466 T8115 T8116 compound test,samples
R4467 T8116 T8114 pobj samples,in
R4468 T8117 T8093 punct .,drawn
R5079 T9686 T9688 amod Western,analysis
R5080 T9687 T9688 compound blot,analysis
R5081 T9688 T9692 nsubj analysis,phosphorylated
R5082 T9689 T9688 prep of,analysis
R5083 T9690 T9689 pobj Akt,of
R5084 T9691 T9688 punct ",",analysis
R5085 T9692 T9692 ROOT phosphorylated,phosphorylated
R5086 T9693 T9692 dobj Akt,phosphorylated
R5087 T9694 T9693 cc and,Akt
R5088 T9695 T9696 compound IκB-α,PBMC
R5089 T9696 T9693 conj PBMC,Akt
R5090 T9697 T9698 auxpass were,incubated
R5091 T9698 T9692 conj incubated,phosphorylated
R5092 T9699 T9698 prep with,incubated
R5093 T9700 T9699 pobj anti-CD3,with
R5094 T9701 T9705 punct (,ml
R5257 T9864 T9862 conj incubated,added
R5258 T9865 T9864 advmod overnight,incubated
R5259 T9866 T9864 prep at,incubated
R5260 T9867 T9868 nummod 4,°
R5261 T9868 T9866 pobj °,at
R5262 T9869 T9862 nsubj C,added
R5263 T9870 T9862 punct .,added
R5264 T9871 T9883 prep After,added
R5265 T9872 T9871 pcomp washing,After
R5266 T9873 T9874 nummod four,times
R5267 T9874 T9872 dobj times,washing
R5268 T9875 T9872 prep with,washing
R5269 T9876 T9875 pobj TBS-T,with
R5270 T9877 T9883 punct ",",added
R5271 T9878 T9881 amod horseradish,antibodies
R5272 T9879 T9881 amod peroxidase-conjugated,antibodies
R5273 T9880 T9881 amod secondary,antibodies
R5274 T9881 T9883 nsubjpass antibodies,added
R5275 T9882 T9883 auxpass were,added
R5276 T9883 T9883 ROOT added,added
R5277 T9884 T9883 cc and,added
R5278 T9885 T9883 conj allowed,added
R5279 T9886 T9887 aux to,incubate
R5280 T9887 T9885 xcomp incubate,allowed
R5281 T9888 T9887 prep for,incubate
R5282 T9889 T9890 nummod 1,hour
R5283 T9890 T9888 pobj hour,for
R5284 T9891 T9887 prep at,incubate
R5285 T9892 T9893 compound room,temperature
R5286 T9893 T9891 pobj temperature,at
R5287 T9894 T9883 punct .,added
R5288 T9895 T9902 prep After,detected
R5289 T9896 T9897 nsubj TBS-T,washing
R7690 T14074 T14073 cc and,PDTC
R7691 T14075 T14073 conj dexamethasone,PDTC
R7692 T14076 T14068 prep in,co-incubated
R7693 T14077 T14076 pobj comparison,in
R7694 T14078 T14077 prep with,comparison
R7695 T14079 T14078 pobj anti-CD3,with
R7696 T14080 T14079 advmod alone,anti-CD3
R7697 T14081 T14083 punct (,±
R7698 T14082 T14083 nummod 38,±
R7699 T14083 T14091 nmod ±,±
R7700 T14084 T14083 nummod 5,±
R7701 T14085 T14083 cc and,±
R7702 T14086 T14087 nummod 54,±
R7703 T14087 T14083 conj ±,±
R7704 T14088 T14091 nummod 11,±
R7705 T14089 T14088 cc versus,11
R7706 T14090 T14088 conj 98,11
R7707 T14091 T14079 dep ±,anti-CD3
R7708 T14092 T14093 nummod 19,pg/ml
R7709 T14093 T14091 appos pg/ml,±
R7710 T14094 T14093 punct ",",pg/ml
R7711 T14095 T14091 conj respectively,±
R7712 T14096 T14099 punct ;,0.05
R7713 T14097 T14098 compound P,<
R7714 T14098 T14099 compound <,0.05
R7715 T14099 T14066 npadvmod 0.05,observed
R7716 T14100 T14099 punct ),0.05
R7717 T14101 T14066 punct .,observed
R7718 T14102 T14104 nummod LY294002,wortmannin
R7719 T14103 T14102 cc and,LY294002
R7720 T14104 T14114 npadvmod wortmannin,inhibited
R7721 T14105 T14104 punct ",",wortmannin
R7722 T14106 T14114 prep as,inhibited
R7723 T14107 T14108 det an,inhibitor
R7735 T14119 T14118 prep in,production
R7736 T14120 T14121 compound RA,PBMC
R7737 T14121 T14119 pobj PBMC,in
R7738 T14122 T14124 punct (,±
R7739 T14123 T14124 nummod 98,±
R7740 T14124 T14121 appos ±,PBMC
R7741 T14125 T14132 nummod 19,P
R7742 T14126 T14125 cc versus,19
R7743 T14127 T14129 quantmod 38,10
R7744 T14128 T14129 quantmod ±,10
R7745 T14129 T14125 conj 10,19
R7746 T14130 T14129 quantmod pg/ml,10
R7747 T14131 T14132 compound [,P
R7748 T14132 T14133 nsubj P,<
R7749 T14133 T14114 conj <,inhibited
R7750 T14134 T14135 nummod 0.005,]
R7751 T14135 T14133 dobj ],<
R7752 T14136 T14135 cc and,]
R7753 T14137 T14142 nummod 48,P
R7754 T14138 T14142 nmod ±,P
R7755 T14139 T14138 nummod 4,±
R7756 T14140 T14142 compound pg/ml,P
R7757 T14141 T14142 compound [,P
R7758 T14142 T14135 conj P,]
R7759 T14143 T14133 conj <,<
R7760 T14144 T14145 nummod 0.05,]
R7761 T14145 T14143 dobj ],<
R7762 T14146 T14145 punct ",",]
R7763 T14147 T14145 npadvmod respectively,]
R7764 T14148 T14145 punct ),]
R7765 T14149 T14133 punct .,<
R7766 T14150 T14152 det The,inhibitors
R7767 T14151 T14152 compound calcineurin,inhibitors
R7768 T14152 T14153 nsubj inhibitors,cyclosporin
R7769 T14153 T14153 ROOT cyclosporin,cyclosporin
R7770 T14154 T14153 dobj A,cyclosporin
R7771 T14155 T14154 cc and,A
R7772 T14156 T14158 nsubj FK506,downregulated
R7773 T14157 T14158 advmod also,downregulated
R7774 T14158 T14153 ccomp downregulated,cyclosporin
R7775 T14159 T14161 det the,secretion
R7776 T14160 T14161 compound IL-17,secretion
R7777 T14161 T14158 dobj secretion,downregulated
R7778 T14162 T14164 advmod as,as
R7779 T14163 T14164 advmod well,as
R7780 T14164 T14161 cc as,secretion
R7781 T14165 T14167 det the,protein
R7782 T14166 T14167 amod mitogen-activated,protein
R7783 T14167 T14168 compound protein,kinase
R7784 T14168 T14161 conj kinase,secretion
R7785 T14169 T14170 punct (,MAPK
R7786 T14170 T14168 appos MAPK,kinase
R7787 T14171 T14170 punct ),MAPK
R7788 T14172 T14175 nummod p38,did
R7789 T14173 T14175 nsubj inhibitor,did
R7790 T14174 T14173 nummod SB203580,inhibitor
R7791 T14175 T14158 conj did,downregulated
R7792 T14176 T14175 punct ",",did
R7793 T14177 T14181 mark whereas,had
R7794 T14178 T14181 nsubj rapamycin,had
R7795 T14179 T14178 cc and,rapamycin
R7796 T14180 T14178 conj PD98059,rapamycin
R7797 T14181 T14175 advcl had,did
R7798 T14182 T14183 det no,effect
R7799 T14183 T14181 dobj effect,had
R7800 T14184 T14183 prep on,effect
R7801 T14185 T14186 compound IL-17,levels
R7802 T14186 T14184 pobj levels,on
R7812 T14196 T14195 prep of,possibility
R7813 T14197 T14198 amod non-specific,inhibition
R7814 T14198 T14196 pobj inhibition,of
R7815 T14199 T14193 prep by,evaluate
R7816 T14200 T14201 det the,drug
R7817 T14201 T14199 pobj drug,by
R7818 T14202 T14193 prep at,evaluate
R7819 T14203 T14204 amod high,concentrations
R7820 T14204 T14202 pobj concentrations,at
R7821 T14205 T14207 punct ",",observed
R7822 T14206 T14207 nsubj we,observed
R7823 T14207 T14207 ROOT observed,observed
R7824 T14208 T14210 det the,response
R7825 T14209 T14210 compound dose,response
R7826 T14210 T14207 dobj response,observed
R7827 T14211 T14210 prep of,response
R7828 T14212 T14211 pobj PDTC,of
R7829 T14213 T14212 cc and,PDTC
R7830 T14214 T14212 conj LY294002,PDTC
R7831 T14215 T14210 prep for,response
R7832 T14216 T14217 det the,inhibition
R7833 T14217 T14215 pobj inhibition,for
R7834 T14218 T14217 prep of,inhibition
R7835 T14219 T14220 amod IL-17,production
R7836 T14220 T14218 pobj production,of
R7837 T14221 T14220 prep in,production
R7838 T14222 T14221 pobj PBMC,in
R7839 T14223 T14207 punct .,observed
R7840 T14224 T14225 expl There,were
R7841 T14225 T14225 ROOT were,were
R7842 T14226 T14227 amod dose-dependent,inhibitions
R7843 T14227 T14225 attr inhibitions,were
R7844 T14228 T14227 prep of,inhibitions
R7845 T14229 T14230 compound IL-17,production
R7846 T14230 T14228 pobj production,of
R4600 T8879 T8871 cc and,U
R4601 T8880 T8881 nummod 0.25,μM
R4602 T8881 T8871 conj μM,U
R4603 T8882 T8881 prep of,μM
R4604 T8883 T8882 pobj sense,of
R4605 T8884 T8883 cc and,sense
R4606 T8885 T8886 amod antisense,primers
R4607 T8886 T8883 conj primers,sense
R4608 T8887 T8863 punct .,performed
R4609 T8888 T8889 det The,reaction
R4610 T8889 T8891 nsubjpass reaction,performed
R4611 T8890 T8891 auxpass was,performed
R4612 T8891 T8891 ROOT performed,performed
R4613 T8892 T8891 prep in,performed
R4614 T8893 T8894 compound PCR,buffer
R4615 T8894 T8892 pobj buffer,in
R4616 T8895 T8898 punct (,MgCl2
R4617 T8896 T8898 nummod 1.5,MgCl2
R4618 T8897 T8898 compound mM,MgCl2
R4619 T8898 T8894 appos MgCl2,buffer
R4620 T8899 T8898 punct ",",MgCl2
R4621 T8900 T8902 nummod 50,KCl
R4622 T8901 T8902 compound mM,KCl
R4623 T8902 T8898 appos KCl,MgCl2
R4624 T8903 T8902 punct ",",KCl
R4625 T8904 T8906 nummod 10,Tris-HCl
R4626 T8905 T8906 compound mM,Tris-HCl
R4627 T8906 T8902 conj Tris-HCl,KCl
R4628 T8907 T8906 punct ",",Tris-HCl
R4629 T8908 T8906 appos pH,Tris-HCl
R4630 T8909 T8908 nummod 8.3,pH
R4631 T8910 T8906 punct ),Tris-HCl
R4643 T8922 T8921 cc and,sense
R4644 T8923 T8924 amod antisense,primers
R4645 T8924 T8921 conj primers,sense
R4646 T8925 T8924 prep for,primers
R4647 T8926 T8927 det each,molecules
R4648 T8927 T8925 pobj molecules,for
R4649 T8928 T8929 auxpass were,used
R4650 T8929 T8929 ROOT used,used
R4651 T8930 T8932 punct :,sense
R4652 T8931 T8932 amod IL-17,sense
R4653 T8932 T8929 dobj sense,used
R4654 T8933 T8932 punct ",",sense
R4655 T8934 T8944 nummod 5,TTG-3
R4656 T8935 T8937 punct ',ATG
R4657 T8936 T8937 punct -,ATG
R4658 T8937 T8944 compound ATG,TTG-3
R4665 T8944 T8932 appos TTG-3,sense
R4666 T8945 T8944 case ',TTG-3
R4667 T8946 T8932 punct ;,sense
R4668 T8947 T8948 compound IL-17,antisense
R4669 T8948 T8932 conj antisense,sense
R4670 T8949 T8948 punct ",",antisense
R4671 T8950 T8948 appos 5,antisense
R4672 T8951 T8950 punct ',5
R4673 T8952 T8954 punct -,GGC
R4674 T8953 T8954 compound TTA,GGC
R4675 T8954 T8960 compound GGC,CGG-3
R4676 T8955 T8960 compound CAC,CGG-3
R4677 T8956 T8960 compound ATG,CGG-3
R4678 T8957 T8960 compound GTG,CGG-3
R4679 T8958 T8960 compound GAC,CGG-3
R4680 T8959 T8960 compound AAT,CGG-3
R4681 T8960 T8948 appos CGG-3,antisense
R4682 T8961 T8948 punct ',antisense
R4683 T8962 T8948 punct ;,antisense
R4684 T8963 T8964 amod glyceraldehyde-3-phosphate,dehydrogenase
R4685 T8964 T8948 appos dehydrogenase,antisense
R4686 T8965 T8966 punct (,GAPDH
R4687 T8966 T8964 appos GAPDH,dehydrogenase
R4688 T8967 T8966 punct ),GAPDH
R4689 T8968 T8948 conj sense,antisense
R4690 T8969 T8948 punct ",",antisense
R4691 T8970 T8948 appos 5,antisense
R4692 T8971 T8970 punct ',5
R4693 T8972 T8979 punct -,C-3
R4694 T8973 T8979 compound CGA,C-3
R4695 T8974 T8979 compound TGC,C-3
R4696 T8975 T8979 compound TGG,C-3
R4697 T8976 T8979 compound GCG,C-3
R4698 T8977 T8979 compound TGA,C-3
R4699 T8978 T8979 compound GTA,C-3
R4719 T8998 T8999 auxpass were,processed
R4720 T8999 T9066 ccomp processed,determined
R4721 T9000 T8999 prep in,processed
R4722 T9001 T9004 det a,cycler
R4723 T9002 T9004 nmod DNA,cycler
R4724 T9003 T9004 amod thermal,cycler
R4725 T9004 T9000 pobj cycler,in
R4726 T9005 T9007 punct (,Cetus
R4727 T9006 T9007 compound Perkin-Elmer,Cetus
R4728 T9007 T9004 appos Cetus,cycler
R4729 T9008 T9007 punct ",",Cetus
R4730 T9009 T9007 npadvmod Norwalk,Cetus
R4731 T9010 T9009 punct ",",Norwalk
R4732 T9011 T9009 conj CT,Norwalk
R4733 T9012 T9011 punct ",",CT
R4734 T9013 T9011 conj USA,CT
R4735 T9014 T9007 punct ),Cetus
R4736 T9015 T8999 prep through,processed
R4737 T9016 T9015 pobj cycles,through
R4738 T9017 T8999 prep for,processed
R4739 T9018 T9017 pobj 30,for
R8467 T15352 T15340 punct .,reached
R8468 T15353 T15360 prep In,remained
R8469 T15354 T15353 pobj contrast,In
R8470 T15355 T15360 punct ",",remained
R8471 T15356 T15357 compound non-phosphorylated,Akt
R8472 T15357 T15360 nsubj Akt,remained
R8473 T15358 T15357 cc and,Akt
R8474 T15359 T15357 conj β-actin,Akt
R8475 T15360 T15360 ROOT remained,remained
R8476 T15361 T15360 acomp unchanged,remained
R8477 T15362 T15360 advmod regardless,remained
R8478 T15363 T15362 prep of,regardless
R8479 T15364 T15365 amod incubation,time
R8480 T15365 T15363 pobj time,of
R8481 T15366 T15360 punct .,remained
R8482 T15367 T15374 nsubj PHA,demonstrated
R8483 T15368 T15367 punct ",",PHA
R8484 T15369 T15370 compound concanavalin,A
R8485 T15370 T15367 conj A,PHA
R8486 T15371 T15370 cc and,A
R8487 T15372 T15374 nsubj IL-15,demonstrated
R8488 T15373 T15374 advmod also,demonstrated
R8489 T15374 T15374 ROOT demonstrated,demonstrated
R8490 T15375 T15377 det the,effect
R7034 T13010 T13011 compound RA,PBMC
R7035 T13011 T13012 nsubj PBMC,include
R7036 T13012 T13012 ROOT include,include
R7037 T13013 T13015 amod several,types
R7038 T13014 T13015 compound cell,types
R7039 T13015 T13012 dobj types,include
R7040 T13016 T13033 prep in,affected
R7041 T13017 T13016 pobj addition,in
R7042 T13018 T13017 prep to,addition
R7043 T13019 T13020 compound T,cells
R7044 T13020 T13018 pobj cells,to
R7045 T13021 T13033 punct ",",affected
R7046 T13022 T13024 det some,cytokines
R7047 T13023 T13024 amod inflammatory,cytokines
R7048 T13024 T13033 nsubj cytokines,affected
R7049 T13025 T13024 acl released,cytokines
R7050 T13026 T13025 prep from,released
R7051 T13027 T13026 pobj macrophages,from
R7052 T13028 T13027 cc and,macrophages
R7053 T13029 T13030 amod other,lymphocytes
R7054 T13030 T13027 conj lymphocytes,macrophages
R7055 T13031 T13033 aux might,affected
R7056 T13032 T13033 aux have,affected
R7057 T13033 T13012 ccomp affected,include
R7058 T13034 T13035 det the,production
R7059 T13035 T13033 dobj production,affected
R7060 T13036 T13035 prep of,production
R7061 T13037 T13036 pobj IL-17,of
R7062 T13038 T13037 prep from,IL-17
R7063 T13039 T13040 compound T,cells
R7064 T13040 T13038 pobj cells,from
R7065 T13041 T13012 punct .,include
R7066 T13042 T13043 aux To,evaluate
R7067 T13043 T13055 advcl evaluate,tested
R7068 T13044 T13045 det the,effects
R7069 T13045 T13043 dobj effects,evaluate
R7070 T13046 T13045 prep of,effects
R7071 T13047 T13048 amod inflammatory,cytokines
R7076 T13052 T13050 pobj PBMC,by
R7077 T13053 T13055 punct ",",tested
R7078 T13054 T13055 nsubj we,tested
R7079 T13055 T13055 ROOT tested,tested
R7080 T13056 T13057 det the,effects
R7081 T13057 T13055 dobj effects,tested
R7082 T13058 T13057 prep of,effects
R7083 T13059 T13060 amod several,cytokines
R7084 T13060 T13058 pobj cytokines,of
R7085 T13061 T13060 cc and,cytokines
R7086 T13062 T13060 conj chemokines,cytokines
R7087 T13063 T13057 prep on,effects
R7088 T13064 T13065 compound IL-17,production
R7089 T13065 T13063 pobj production,on
R7090 T13066 T13055 punct .,tested
R7091 T13067 T13068 nsubj We,detected
R7092 T13068 T13068 ROOT detected,detected
R7093 T13069 T13070 det an,increase
R7094 T13070 T13068 dobj increase,detected
R7095 T13071 T13070 prep in,increase
R7096 T13072 T13073 compound IL-17,level
R7097 T13073 T13071 pobj level,in
R7098 T13074 T13068 prep after,detected
R7099 T13075 T13074 pobj stimulation,after
R7100 T13076 T13068 prep with,detected
R7101 T13077 T13076 pobj IL-15,with
R7102 T13078 T13077 punct (,IL-15
R7103 T13079 T13080 nummod 10,ng/ml
R7104 T13080 T13077 appos ng/ml,IL-15
R7105 T13081 T13077 punct ),IL-15
R7106 T13082 T13068 punct ",",detected
R7107 T13083 T13112 mark whereas,were
R7108 T13084 T13112 prep with,were
R7109 T13085 T13084 pobj IL-1β,with
R7110 T13086 T13085 punct (,IL-1β
R7111 T13087 T13088 nummod 10,ng/ml
R7112 T13088 T13085 appos ng/ml,IL-1β
R7190 T13166 T13165 prep with,observed
R7191 T13167 T13166 pobj IL-8,with
R7192 T13168 T13167 punct (,IL-8
R7193 T13169 T13170 nummod 10,ng/ml
R7194 T13170 T13167 appos ng/ml,IL-8
R7195 T13171 T13167 punct ),IL-8
R7196 T13172 T13165 punct ",",observed
R7197 T13173 T13165 conj MIP-1α,observed
R7198 T13174 T13173 punct (,MIP-1α
R7199 T13175 T13176 nummod 10,ng/ml
R7200 T13176 T13173 appos ng/ml,MIP-1α
R7201 T13177 T13176 punct ),ng/ml
R7202 T13178 T13173 cc or,MIP-1α
R7203 T13179 T13173 conj MIP-1β,MIP-1α
R10801 T20418 T20417 cc and,IL-1
R10802 T20419 T20417 conj TNF-α,IL-1
R10803 T20420 T20420 ROOT are,are
R10804 T20421 T20420 acomp abundant,are
R10805 T20422 T20421 prep in,abundant
R10806 T20423 T20424 amod rheumatoid,synovium
R10807 T20424 T20422 pobj synovium,in
R10808 T20425 T20420 punct ",",are
R10809 T20426 T20439 mark whereas,proved
R10810 T20427 T20430 det the,cytokines
R10811 T20428 T20430 nmod T,cytokines
R10812 T20429 T20430 amod cell-derived,cytokines
R10813 T20430 T20439 nsubj cytokines,proved
R10814 T20431 T20430 punct ",",cytokines
R10815 T20432 T20433 advmod especially,IL-4
R10816 T20433 T20430 appos IL-4,cytokines
R10817 T20434 T20433 cc and,IL-4
R10818 T20435 T20433 conj interferon-γ,IL-4
R10819 T20436 T20439 punct ",",proved
R10820 T20437 T20439 aux have,proved
R10821 T20438 T20439 advmod often,proved
R10822 T20439 T20420 advcl proved,are
R10823 T20440 T20439 oprd difficult,proved
R10824 T20441 T20442 aux to,detect
R10825 T20442 T20440 xcomp detect,difficult
R10826 T20443 T20442 prep in,detect
R10827 T20444 T20445 compound RA,synovium
R10828 T20445 T20446 compound synovium,[
R10853 T20470 T20467 pobj cytokines,of
R10854 T20471 T20472 aux has,limited
R10855 T20472 T20472 ROOT limited,limited
R10856 T20473 T20474 poss its,importance
R10857 T20474 T20472 dobj importance,limited
R10858 T20475 T20472 punct .,limited
R10859 T20476 T20482 prep In,appealing
R10860 T20477 T20478 det this,respect
R10861 T20478 T20476 pobj respect,In
R10862 T20479 T20482 punct ",",appealing
R10863 T20480 T20482 nsubj IL-17,appealing
R10864 T20481 T20482 aux is,appealing
R10865 T20482 T20482 ROOT appealing,appealing
R10866 T20483 T20487 mark because,described
R10867 T20484 T20487 nsubjpass it,described
R599 T1443 T1445 amod Increased,production
R600 T1444 T1445 amod interleukin-17,production
R601 T1445 T1445 ROOT production,production
R602 T1446 T1445 prep via,production
R603 T1447 T1449 det a,3-kinase/Akt
R604 T1448 T1449 compound phosphoinositide,3-kinase/Akt
R605 T1449 T1446 pobj 3-kinase/Akt,via
R606 T1450 T1449 cc and,3-kinase/Akt
R607 T1451 T1452 amod nuclear,factor
R608 T1452 T1449 conj factor,3-kinase/Akt
R609 T1453 T1445 punct κ,production
R610 T1454 T1455 amod B-dependent,pathway
R611 T1455 T1465 nsubjpass pathway,recognized
R612 T1456 T1455 prep in,pathway
R613 T1457 T1456 pobj patients,in
R614 T1458 T1457 prep with,patients
R615 T1459 T1460 compound rheumatoid,arthritis
R616 T1460 T1458 pobj arthritis,with
R617 T1461 T1462 amod Inflammatory,mediators
R618 T1462 T1465 nsubjpass mediators,recognized
R619 T1463 T1465 aux have,recognized
R620 T1464 T1465 auxpass been,recognized
R621 T1465 T1465 ROOT recognized,recognized
R622 T1466 T1465 prep as,recognized
R623 T1467 T1466 pcomp being,as
R624 T1468 T1467 acomp important,being
R625 T1469 T1467 prep in,being
R626 T1470 T1471 det the,pathogenesis
R627 T1471 T1469 pobj pathogenesis,in
R628 T1472 T1471 prep of,pathogenesis
R629 T1473 T1474 amod rheumatoid,arthritis
R630 T1474 T1472 pobj arthritis,of
R631 T1475 T1476 punct (,RA
R632 T1476 T1471 appos RA,pathogenesis
R4381 T8030 T8032 det the,reaction
R4382 T8031 T8032 compound color,reaction
R4383 T8032 T8029 dobj reaction,develop
R4384 T8033 T8004 punct .,incubated
R4385 T8034 T8035 det The,reaction
R4386 T8035 T8037 nsubjpass reaction,stopped
R4387 T8036 T8037 auxpass was,stopped
R4388 T8037 T8037 ROOT stopped,stopped
R4389 T8038 T8037 agent by,stopped
R4390 T8039 T8040 det the,addition
R4391 T8040 T8038 pobj addition,by
R4392 T8041 T8040 prep of,addition
R4393 T8042 T8044 nummod 1,NaOH
R4394 T8043 T8044 compound M,NaOH
R4395 T8044 T8041 pobj NaOH,of
R4396 T8045 T8044 cc and,NaOH
R4397 T8046 T8048 det the,density
R4398 T8047 T8048 amod optical,density
R4399 T8048 T8044 conj density,NaOH
R4400 T8049 T8048 prep of,density
R4401 T8050 T8051 det each,well
R4402 T8051 T8049 pobj well,of
R4403 T8052 T8053 auxpass was,read
R4404 T8053 T8037 conj read,stopped
R4405 T8054 T8053 prep at,read
R4406 T8055 T8056 nummod 405,nm
R4407 T8056 T8054 pobj nm,at
R4408 T8057 T8053 punct .,read
R4409 T8058 T8060 det The,limit
R4410 T8059 T8060 amod lower,limit
R4411 T8060 T8064 nsubj limit,was
R4412 T8061 T8060 prep of,limit
R4413 T8062 T8063 compound IL-17,detection
R4414 T8063 T8061 pobj detection,of
R4415 T8064 T8064 ROOT was,was

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T1142 42-67 Protein denotes phosphoinositide 3-kinase
T1143 68-71 Protein denotes Akt
T1144 25-35 Gene_expression denotes production
T1145 25-35 Gene_expression denotes production
T1146 0-9 Positive_regulation denotes Increased
T1147 0-9 Positive_regulation denotes Increased
T22384 28654-28666 Gene_expression denotes introduction
T22383 28670-28680 Protein denotes anti-IL-17
T22382 28413-28423 Positive_regulation denotes activation
T22381 28270-28282 Positive_regulation denotes upregulation
T22380 28407-28412 Protein denotes NF-κB
T22379 28380-28383 Protein denotes Akt
T22378 28375-28379 Protein denotes PI3K
T22377 28286-28291 Protein denotes IL-17
T22376 28172-28180 Positive_regulation denotes response
T22375 28172-28180 Positive_regulation denotes response
T22374 28136-28146 Gene_expression denotes production
T22373 28136-28146 Gene_expression denotes production
T22372 28235-28244 Protein denotes anti-CD28
T22371 28226-28234 Protein denotes anti-CD3
T22370 28194-28199 Protein denotes MCP-1
T22369 28184-28189 Protein denotes IL-15
T22368 28161-28168 Protein denotes RA PBMC
T22367 28150-28155 Protein denotes IL-17
T19792 27897-27906 Positive_regulation denotes induction
T19791 27996-28001 Protein denotes IL-17
T19790 27910-27920 Protein denotes anti-IL-17
T19789 27760-27768 Negative_regulation denotes blocking
T19788 27760-27768 Negative_regulation denotes blocking
T19787 27760-27768 Negative_regulation denotes blocking
T19786 27760-27768 Negative_regulation denotes blocking
T19785 27778-27785 Binding denotes binding
T19784 27778-27785 Binding denotes binding
T19783 27778-27785 Binding denotes binding
T19782 27778-27785 Binding denotes binding
T19781 27627-27637 Positive_regulation denotes activation
T19780 27802-27816 Protein denotes IL-17 promoter
T19779 27772-27777 Protein denotes NF-κB
T19778 27621-27626 Protein denotes NF-κB
T19777 27603-27606 Protein denotes Akt
T19776 27598-27602 Protein denotes PI3K
T19775 27420-27431 Binding denotes association
T19774 27420-27431 Binding denotes association
T19773 27544-27549 Protein denotes IL-17
T19772 27437-27442 Protein denotes NF-κB
T19771 27413-27416 Protein denotes Akt
T19770 27382-27386 Protein denotes PI3K
T19769 27222-27226 Protein denotes AP-1
T19768 27158-27166 Regulation denotes involved
T19767 27158-27166 Regulation denotes involved
T19766 27174-27183 Positive_regulation denotes induction
T19765 27174-27183 Positive_regulation denotes induction
T19764 27029-27038 Positive_regulation denotes activated
T19763 27029-27038 Positive_regulation denotes activated
T19762 27029-27038 Positive_regulation denotes activated
T19761 27196-27203 Protein denotes RA PBMC
T19760 27187-27192 Protein denotes IL-17
T19759 27127-27132 Protein denotes NF-κB
T19758 27062-27067 Protein denotes IL-15
T19713 25916-25921 Protein denotes NF-κB
T19712 25899-25907 Protein denotes LY294002
T19711 25884-25888 Protein denotes PI3K
T19710 25842-25849 Protein denotes RA PBMC
T19709 25810-25813 Protein denotes CD3
T19708 25755-25764 Positive_regulation denotes induction
T19707 25777-25784 Protein denotes RA PBMC
T19706 25768-25773 Protein denotes IL-17
T19705 25600-25609 Regulation denotes regulated
T19704 25582-25592 Gene_expression denotes production
T19703 25576-25581 Protein denotes IL-17
T19702 25497-25502 Protein denotes IL-17
T19701 25383-25392 Positive_regulation denotes increases
T19700 25383-25392 Positive_regulation denotes increases
T19699 25399-25408 Positive_regulation denotes induction
T19698 25399-25408 Positive_regulation denotes induction
T19697 25412-25419 Protein denotes RA PBMC
T19696 25393-25398 Protein denotes IL-17
T19695 25373-25377 Protein denotes CD28
T19694 25359-25372 Protein denotes anti-CD3/anti
T19693 25080-25085 Protein denotes TNF-α
T19692 25025-25030 Protein denotes IL-15
T19691 24949-24955 Regulation denotes affect
T19690 24949-24955 Regulation denotes affect
T19689 24962-24972 Gene_expression denotes production
T19688 24956-24961 Protein denotes IL-17
T19687 24849-24854 Protein denotes TNF-α
T19686 24840-24844 Protein denotes IL-1
T19685 24776-24784 Binding denotes ligation
T19684 24772-24775 Protein denotes TCR
T19683 24763-24768 Protein denotes MCP-1
T19682 24754-24759 Protein denotes IL-15
T19681 24701-24710 Positive_regulation denotes increased
T19680 24701-24710 Positive_regulation denotes increased
T19679 24701-24710 Positive_regulation denotes increased
T19678 24701-24710 Positive_regulation denotes increased
T19677 24701-24710 Positive_regulation denotes increased
T19676 24701-24710 Positive_regulation denotes increased
T19675 24701-24710 Positive_regulation denotes increased
T19674 24701-24710 Positive_regulation denotes increased
T19673 24715-24725 Gene_expression denotes production
T19672 24715-24725 Gene_expression denotes production
T19671 24678-24686 Binding denotes ligation
T19670 24678-24686 Binding denotes ligation
T19669 24738-24745 Protein denotes RA PBMC
T19668 24729-24734 Protein denotes IL-17
T19667 24674-24677 Protein denotes TCR
T19666 24657-24662 Protein denotes MCP-1
T19665 24647-24652 Protein denotes IL-15
T19664 24582-24590 Binding denotes ligation
T19663 24582-24590 Binding denotes ligation
T19662 24457-24467 Gene_expression denotes production
T19661 24457-24467 Gene_expression denotes production
T19660 24606-24615 Protein denotes anti-CD28
T19659 24602-24605 Protein denotes CD3
T19658 24577-24580 Protein denotes TCR
T19657 24560-24575 Protein denotes T cell receptor
T19656 24480-24487 Protein denotes RA PBMC
T19655 24471-24476 Protein denotes IL-17
T19654 24288-24297 Positive_regulation denotes stimulate
T19653 24304-24314 Gene_expression denotes production
T19652 24298-24303 Protein denotes IL-17
T19651 24095-24102 Localization denotes secrete
T19638 23486-23491 Protein denotes IL-17
T19637 23381-23393 Positive_regulation denotes upregulation
T19636 23397-23402 Protein denotes IL-17
T19635 23228-23243 Protein denotes T cell receptor
T19634 23192-23201 Protein denotes anti-CD28
T19633 23188-23191 Protein denotes CD3
T19632 22975-22984 Positive_regulation denotes stimulate
T19631 23045-23055 Gene_expression denotes production
T19630 22991-23001 Gene_expression denotes production
T19629 23089-23093 Protein denotes CD28
T19628 23080-23083 Protein denotes CD3
T19627 23039-23044 Protein denotes IL-17
T19626 22985-22990 Protein denotes IL-17
T19625 22349-22361 Protein denotes interferon-γ
T19624 22340-22344 Protein denotes IL-4
T19623 22248-22253 Protein denotes TNF-α
T19622 22239-22243 Protein denotes IL-1
T19621 22004-22009 Protein denotes IL-17
T16257 21881-21886 Protein denotes NF-κB
T16256 21834-21843 Protein denotes anti-CD28
T16255 21820-21828 Protein denotes anti-CD3
T16254 21769-21773 Protein denotes AP-1
T16253 21668-21678 Negative_regulation denotes inhibition
T16252 21682-21693 Protein_catabolism denotes degradation
T16251 21742-21749 Protein denotes Fig. 7c
T16250 21697-21702 Protein denotes IκB-α
T16249 21655-21660 Protein denotes IκB-α
T16248 21568-21573 Negative_regulation denotes block
T16247 21568-21573 Negative_regulation denotes block
T16246 21624-21631 Protein denotes Fig. 7c
T16245 21608-21622 Protein denotes IL-17 promoter
T16241 21446-21451 Protein denotes NF-κB
T16240 21428-21432 Protein denotes PI3K
T16239 21360-21367 Binding denotes intense
T16238 21313-21323 Positive_regulation denotes activation
T16237 21313-21323 Positive_regulation denotes activation
T16236 21390-21397 Protein denotes Fig. 7b
T16235 21381-21388 Protein denotes RA PBMC
T16234 21341-21350 Protein denotes anti-CD28
T16233 21327-21335 Protein denotes anti-CD3
T16232 21307-21312 Protein denotes NF-κB
T16231 21200-21203 Protein denotes p50
T16230 21192-21195 Protein denotes p65
T16229 21051-21060 Positive_regulation denotes increased
T16228 21051-21060 Positive_regulation denotes increased
T16227 21061-21068 Binding denotes binding
T16226 21061-21068 Binding denotes binding
T16225 20989-20999 Positive_regulation denotes stimulated
T16224 20989-20999 Positive_regulation denotes stimulated
T16223 21081-21096 Protein denotes IL-17 promoters
T16222 21072-21077 Protein denotes NF-κB
T16221 21019-21028 Protein denotes anti-CD28
T16220 21005-21013 Protein denotes anti-CD3
T16219 20981-20988 Protein denotes RA PBMC
T16218 20950-20953 Protein denotes Fig
T16217 20797-20805 Positive_regulation denotes inducing
T16216 20812-20822 Gene_expression denotes expression
T16215 20931-20936 Protein denotes IL-17
T16214 20887-20910 Protein denotes NF-κB recognition sites
T16213 20806-20811 Protein denotes IL-17
T16212 20770-20775 Protein denotes IL-15
T14574 19694-19699 Protein denotes NF-κB
T14573 19659-19663 Protein denotes PI3K
T14572 19623-19631 Protein denotes anti-CD3
T12895 17690-17703 Positive_regulation denotes upregulations
T12894 17873-17879 Protein denotes MIP-1β
T12893 17852-17858 Protein denotes MIP-1α
T12892 17835-17839 Protein denotes IL-8
T12891 17707-17721 Protein denotes IL-17 proteins
T12890 17661-17665 Protein denotes IL-6
T12889 17602-17611 Positive_regulation denotes unchanged
T12888 17602-17611 Positive_regulation denotes unchanged
T12887 17602-17611 Positive_regulation denotes unchanged
T12886 17602-17611 Positive_regulation denotes unchanged
T12885 17602-17611 Positive_regulation denotes unchanged
T12884 17602-17611 Positive_regulation denotes unchanged
T12883 17613-17620 Protein denotes Fig. 2a
T12882 17560-17565 Protein denotes TGF-β
T12881 17540-17545 Protein denotes IL-18
T12880 17522-17527 Protein denotes TNF-α
T12879 17504-17509 Protein denotes IL-1β
T12878 17473-17478 Protein denotes IL-15
T12877 17061-17068 Protein denotes RA PBMC
T12876 16970-16980 Regulation denotes Regulation
T12875 16990-17000 Gene_expression denotes production
T12874 16984-16989 Protein denotes IL-17
T12008 16846-16855 Positive_regulation denotes increased
T12007 16893-16897 Binding denotes than
T12006 16862-16872 Gene_expression denotes production
T12005 16916-16925 Protein denotes anti-CD28
T12004 16903-16911 Protein denotes anti-CD3
T12003 16856-16861 Protein denotes IL-17
T12002 16841-16844 Protein denotes PHA
T12001 16623-16634 Positive_regulation denotes upregulated
T12000 16714-16722 Gene_expression denotes produced
T11999 16714-16722 Gene_expression denotes produced
T11998 16641-16651 Gene_expression denotes production
T11997 16773-16776 Protein denotes CD3
T11996 16723-16733 Protein denotes more IL-17
T11995 16705-16713 Protein denotes anti-CD3
T11994 16691-16700 Protein denotes anti-CD28
T11993 16635-16640 Protein denotes IL-17
T11992 16600-16608 Protein denotes anti-CD3
T11991 16591-16598 Protein denotes Table 1
T11990 16569-16577 Protein denotes anti-CD3
T11989 16451-16459 Positive_regulation denotes increase
T11988 16272-16280 Gene_expression denotes produced
T11987 16463-16468 Protein denotes IL-17
T11986 16221-16226 Protein denotes IL-17
T11985 16120-16129 Positive_regulation denotes Increased
T11984 16120-16129 Positive_regulation denotes Increased
T11983 16136-16146 Gene_expression denotes production
T11982 16136-16146 Gene_expression denotes production
T11981 16199-16203 Protein denotes CD28
T11980 16183-16186 Protein denotes CD3
T11393 15952-15962 Positive_regulation denotes stimulated
T11392 15941-15951 Gene_expression denotes production
T11391 15966-15969 Protein denotes PHA
T11390 15935-15940 Protein denotes IL-17
T11389 15707-15712 Protein denotes IL-17
T10435 14837-14842 Protein denotes c-Rel
T10434 14829-14832 Protein denotes p65
T10433 14824-14827 Protein denotes p50
T10432 14809-14823 Protein denotes NF-κB subunits
T10431 14107-14113 Protein denotes TaKaRa
T10430 14081-14105 Protein denotes T4 polynucleotide kinase
T10429 13965-13968 Protein denotes TAC
T10428 13898-13903 Protein denotes NF-κB
T10427 13782-13787 Protein denotes NF-κB
T9632 13276-13279 Protein denotes Akt
T9631 12526-12540 Phosphorylation denotes phosphorylated
T9630 12549-12554 Protein denotes IκB-α
T9629 12541-12544 Protein denotes Akt
T9628 12521-12524 Protein denotes Akt
T9639 13474-13496 Protein denotes horseradish peroxidase
T9638 13467-13472 Protein denotes TBS-T
T9637 13281-13295 Phosphorylation denotes phosphorylated
T9636 13281-13295 Phosphorylation denotes phosphorylated
T9635 13281-13295 Phosphorylation denotes phosphorylated
T9634 13304-13309 Protein denotes IκB-α
T9633 13296-13299 Protein denotes Akt
T8697 12486-12493 Gene_expression denotes product
T8696 12480-12485 Protein denotes GAPDH
T8695 12297-12302 Protein denotes IL-17
T8694 12287-12292 Protein denotes GAPDH
T8693 12186-12191 Protein denotes IL-17
T8692 12176-12181 Protein denotes GAPDH
T8691 11957-11962 Protein denotes GAPDH
T7802 10878-10883 Protein denotes IL-17
T7801 10613-10636 Protein denotes Recombinant human IL-17
T7800 10583-10588 Protein denotes IL-17
T7799 10254-10264 Protein denotes peroxidase
T7798 9780-9783 Protein denotes BSA
T7797 9765-9778 Protein denotes serum albumin
T7796 9463-9468 Protein denotes IL-17
T6947 9400-9405 Protein denotes CD4 T
T6946 9056-9069 Protein denotes phycoerythrin
T6945 9052-9055 Protein denotes CD4
T6944 8823-8837 Protein denotes MACS MS column
T6943 8506-8509 Protein denotes CD4
T6942 8357-8360 Protein denotes CD4
T6941 8322-8325 Protein denotes CD4
T5574 7101-7130 Protein denotes anti-CD28 monoclonal antibody
T5573 7068-7096 Protein denotes Anti-CD3 monoclonal antibody
T5572 7010-7018 Gene_expression denotes obtained
T5571 7010-7018 Gene_expression denotes obtained
T5570 6921-6924 Protein denotes PHA
T5569 6901-6919 Protein denotes Phytohemagglutinin
T5568 6802-6813 Protein denotes Endogen Inc
T5567 6777-6781 Protein denotes IL-1
T5566 6755-6772 Protein denotes Recombinant TNF-α
T5565 6602-6606 Protein denotes IL-8
T5564 6593-6597 Protein denotes IL-6
T5563 6585-6591 Protein denotes MIP-1β
T5562 6492-6533 Protein denotes IL-15, monocyte chemoattractant protein-1
T5561 6485-6490 Protein denotes IL-18
T5560 6466-6483 Protein denotes Recombinant IL-17
T3652 5458-5472 Gene_expression denotes overproduction
T3651 5497-5511 Protein denotes cytokine IL-17
T3650 5427-5432 Protein denotes NF-κB
T3649 5419-5422 Protein denotes Akt
T3648 5413-5417 Protein denotes PI3K
T3647 5386-5411 Protein denotes phosphoinositide 3-kinase
T3646 5247-5257 Gene_expression denotes production
T3645 5241-5246 Protein denotes IL-17
T3644 5010-5015 Protein denotes IL-17
T3643 4962-4966 Protein denotes CD8+
T3642 4953-4957 Protein denotes CD4+
T3641 4635-4643 Localization denotes secreted
T3640 4628-4633 Protein denotes IL-15
T3639 4497-4503 Positive_regulation denotes higher
T3638 4443-4449 Gene_expression denotes Levels
T3637 4590-4594 Protein denotes CD4+
T3636 4453-4458 Protein denotes IL-17
T3635 4225-4235 Positive_regulation denotes stimulates
T3634 4240-4250 Gene_expression denotes production
T3633 4254-4258 Protein denotes IL-6
T3632 4137-4154 Protein denotes nuclear factor κB
T3631 4035-4040 Protein denotes IL-17
T3630 3920-3925 Protein denotes IL-17
T3629 3914-3918 Protein denotes IL-1
T3628 3904-3909 Protein denotes TNF-α
T3627 3791-3797 Positive_regulation denotes induce
T3626 3791-3797 Positive_regulation denotes induce
T3625 3743-3751 Localization denotes secreted
T3624 3743-3751 Localization denotes secreted
T3623 3743-3751 Localization denotes secreted
T3622 3807-3811 Protein denotes IL-8
T3621 3798-3802 Protein denotes IL-6
T3620 3700-3705 Protein denotes IL-17
T3619 3555-3571 Protein denotes type II collagen
T3618 3336-3344 Gene_expression denotes abundant
T3617 3336-3344 Gene_expression denotes abundant
T3616 3336-3344 Gene_expression denotes abundant
T3615 3336-3344 Gene_expression denotes abundant
T3614 3336-3344 Gene_expression denotes abundant
T3613 3336-3344 Gene_expression denotes abundant
T3612 3348-3367 Protein denotes rheumatoid synovium
T3611 3325-3330 Protein denotes TNF-α
T3610 3315-3320 Protein denotes IL-18
T3609 3308-3313 Protein denotes IL-15
T3608 3302-3306 Protein denotes IL-6
T3607 3296-3300 Protein denotes IL-1
T3606 3208-3220 Protein denotes interferon-γ
T3605 3199-3203 Protein denotes IL-2
T3604 2713-2723 Negative_regulation denotes inhibitors
T3603 2713-2723 Negative_regulation denotes inhibitors
T3602 2762-2780 Protein denotes interleukin (IL)-1
T3601 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T1215 2345-2359 Gene_expression denotes overproduction
T1214 2384-2398 Protein denotes cytokine IL-17
T1213 2319-2324 Protein denotes NF-κB
T1212 2311-2314 Protein denotes Akt
T1211 2306-2310 Protein denotes PI3K
T1210 2212-2218 Regulation denotes affect
T1209 2212-2218 Regulation denotes affect
T1208 2225-2235 Gene_expression denotes production
T1207 2124-2134 Negative_regulation denotes inhibition
T1206 2124-2134 Negative_regulation denotes inhibition
T1205 2219-2224 Protein denotes IL-17
T1204 2162-2203 Protein denotes extracellular signal-regulated kinase 1/2
T1203 2138-2157 Protein denotes activator protein-1
T1202 2066-2075 Negative_regulation denotes inhibitor
T1201 2066-2075 Negative_regulation denotes inhibitor
T1200 1974-1981 Negative_regulation denotes blocked
T1199 1932-1941 Positive_regulation denotes activated
T1198 1932-1941 Positive_regulation denotes activated
T1197 1918-1928 Gene_expression denotes production
T1196 2062-2065 Protein denotes Akt
T1195 2057-2061 Protein denotes PI3K
T1194 2005-2010 Protein denotes NF-κB
T1193 1942-1949 Protein denotes RA PBMC
T1192 1848-1860 Positive_regulation denotes augmentation
T1191 1848-1860 Positive_regulation denotes augmentation
T1190 1764-1773 Positive_regulation denotes activated
T1189 1883-1888 Protein denotes NF-κB
T1188 1864-1881 Protein denotes nuclear factor κB
T1187 1783-1786 Protein denotes Akt
T1186 1778-1782 Protein denotes PI3K
T1185 1746-1763 Protein denotes Anti-CD3 antibody
T1184 1689-1699 Gene_expression denotes expression
T1183 1625-1633 Gene_expression denotes detected
T1182 1737-1744 Protein denotes RA PBMC
T1181 1610-1615 Protein denotes IL-17
T1180 1482-1493 Positive_regulation denotes upregulated
T1179 1482-1493 Positive_regulation denotes upregulated
T1178 1500-1510 Gene_expression denotes production
T1177 1563-1568 Protein denotes IL-18
T1176 1556-1561 Protein denotes IL-1β
T1175 1531-1554 Protein denotes tumor necrosis factor-α
T1174 1494-1499 Protein denotes IL-17
T1173 1477-1481 Protein denotes IL-6
T1172 1431-1472 Protein denotes IL-15, monocyte chemoattractant protein-1
T1171 1296-1305 Positive_regulation denotes increased
T1170 1258-1268 Gene_expression denotes production
T1169 1376-1379 Protein denotes PHA
T1168 1362-1371 Protein denotes anti-CD28
T1167 1328-1345 Protein denotes anti-CD3 antibody
T1166 1272-1277 Protein denotes IL-17
T1165 1126-1131 Protein denotes IL-17
T1164 1070-1073 Protein denotes PHA
T1163 1050-1068 Protein denotes phytohemagglutinin
T1162 1039-1048 Protein denotes anti-CD28
T1161 1029-1037 Protein denotes anti-CD3
T1160 792-796 Regulation denotes role
T1159 856-866 Regulation denotes regulation
T1158 876-886 Gene_expression denotes production
T1157 870-875 Protein denotes IL-17
T1156 837-840 Protein denotes Akt
T1155 831-835 Protein denotes PI3K
T1154 804-829 Protein denotes phosphoinositide 3-kinase
T1153 708-716 Regulation denotes regulate
T1152 723-733 Gene_expression denotes production
T1151 717-722 Protein denotes IL-17
T1150 461-471 Gene_expression denotes expression
T1149 504-509 Protein denotes IL-17
T1148 273-292 Protein denotes Interleukin (IL)-17
T19650 24095-24102 Localization denotes secrete
T19649 24095-24102 Localization denotes secrete
T19648 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T19647 24135-24139 Protein denotes IL-8
T19646 24129-24133 Protein denotes IL-6
T19645 23770-23779 Positive_regulation denotes augmented
T19644 23791-23802 Binding denotes recognizing
T19643 23825-23833 Protein denotes collagen
T19642 23803-23819 Protein denotes type II collagen
T19641 23632-23636 Protein denotes CD8+
T19640 23495-23503 Gene_expression denotes produced
T19639 23524-23527 Protein denotes CD4
T19719 26110-26119 Negative_regulation denotes inhibitor
T19718 26101-26109 Protein denotes p38 MAPK
T19717 26023-26026 Protein denotes CD3
T19716 25814-25821 Positive_regulation denotes induced
T19715 25868-25876 Positive_regulation denotes hampered
T19714 25828-25838 Gene_expression denotes production
T19757 27051-27060 Protein denotes anti-CD28
T19756 27042-27050 Protein denotes anti-CD3
T19755 27014-27019 Protein denotes NF-κB
T19754 26936-26947 Regulation denotes involvement
T19753 26963-26972 Positive_regulation denotes induction
T19752 26873-26887 Phosphorylation denotes phosphorylated
T19751 26976-26981 Protein denotes IL-17
T19750 26951-26955 Protein denotes PI3K
T19749 26898-26901 Protein denotes CD3
T19748 26866-26869 Protein denotes Akt
T19747 26823-26827 Negative_regulation denotes loss
T19746 26788-26798 Positive_regulation denotes activation
T19745 26784-26787 Protein denotes Akt
T19744 26742-26746 Protein denotes PI3K
T19743 26649-26659 Gene_expression denotes production
T19742 26643-26648 Protein denotes IL-17
T19741 26633-26638 Protein denotes NF-κB
T19740 26625-26628 Protein denotes p38
T19739 26581-26591 Positive_regulation denotes activation
T19738 26487-26496 Negative_regulation denotes decreased
T19737 26466-26473 Binding denotes binding
T19736 26430-26438 Regulation denotes affected
T19735 26411-26421 Positive_regulation denotes activation
T19734 26576-26580 Protein denotes PI3K
T19733 26544-26547 Protein denotes p38
T19732 26460-26465 Protein denotes NF-κB
T19731 26402-26410 Protein denotes p38 MAPK
T19730 26354-26361 Binding denotes binding
T19729 26285-26294 Positive_regulation denotes stimulate
T19728 26267-26276 Positive_regulation denotes activated
T19727 26236-26245 Positive_regulation denotes activated
T19726 26349-26353 Protein denotes CREB
T19725 26326-26348 Protein denotes histone acetylase p300
T19724 26295-26300 Protein denotes NF-κB
T19723 26277-26280 Protein denotes p38
T19722 26220-26232 Protein denotes IκB kinase-β
T19721 26202-26205 Protein denotes p38
T19720 26192-26197 Protein denotes NF-κB
T16211 20762-20765 Protein denotes PHA
T16210 20746-20760 Protein denotes concanavalin A
T16209 20735-20744 Protein denotes anti-CD28
T16208 20721-20729 Protein denotes anti-CD3
T16207 20557-20567 Positive_regulation denotes Activation
T16206 20557-20567 Positive_regulation denotes Activation
T16205 20557-20567 Positive_regulation denotes Activation
T16204 20627-20641 Protein denotes IL-17 promoter
T16203 20606-20610 Protein denotes AP-1
T16202 20585-20604 Protein denotes activator protein-1
T16201 20575-20580 Protein denotes NF-κB
T16244 21574-21579 Protein denotes NF-κB
T16243 21494-21501 Binding denotes binding
T16242 21488-21493 Protein denotes NF-κB
T15166 20425-20439 Phosphorylation denotes phosphorylated
T15165 20463-20466 Protein denotes CD3
T15164 20440-20443 Protein denotes Akt
T15163 20382-20387 Protein denotes IL-15
T15162 20363-20377 Protein denotes concanavalin A
T15161 20358-20361 Protein denotes PHA
T15160 20273-20291 Phosphorylation denotes non-phosphorylated
T15159 20273-20291 Phosphorylation denotes non-phosphorylated
T15158 20300-20307 Protein denotes β-actin
T15157 20292-20295 Protein denotes Akt
T15156 20051-20065 Phosphorylation denotes phosphorylated
T15155 20066-20069 Protein denotes Akt
T15154 19941-19944 Protein denotes Fig
T15153 19890-19900 Positive_regulation denotes activation
T15152 19904-19907 Protein denotes Akt
T15151 19859-19863 Protein denotes PI3K
T15150 19726-19736 Positive_regulation denotes Activation
T15149 19726-19736 Positive_regulation denotes Activation
T15148 19745-19748 Protein denotes Akt
T15147 19740-19744 Protein denotes PI3K
T13891 18739-18743 Protein denotes MAPK
T13890 18705-18737 Protein denotes mitogen-activated protein kinase
T13889 18674-18679 Protein denotes IL-17
T13888 18604-18615 Protein denotes calcineurin
T13887 18422-18431 Negative_regulation denotes inhibitor
T13886 18474-18477 Protein denotes CD3
T13885 18435-18439 Protein denotes PI3K
T13884 18256-18265 Negative_regulation denotes inhibitor
T13883 18309-18317 Protein denotes anti-CD3
T13882 18250-18255 Protein denotes NF-κB
T13881 18185-18188 Protein denotes CD3
T13880 18145-18148 Protein denotes Fig
T13879 17903-17913 Negative_regulation denotes Inhibition
T13878 17923-17933 Gene_expression denotes production
T13877 17917-17922 Protein denotes IL-17
T13918 19230-19237 Regulation denotes effects
T13917 19323-19330 Protein denotes Fig. 4b
T13916 19117-19124 Protein denotes Fig. 4a
T13915 18993-19003 Negative_regulation denotes inhibition
T13914 19013-19023 Gene_expression denotes production
T13913 19007-19012 Protein denotes IL-17
T13912 18656-18669 Negative_regulation denotes downregulated
T13911 18656-18669 Negative_regulation denotes downregulated
T13910 18656-18669 Negative_regulation denotes downregulated
T13909 18656-18669 Negative_regulation denotes downregulated
T13908 18810-18816 Regulation denotes effect
T13907 18749-18758 Negative_regulation denotes inhibitor
T13906 18749-18758 Negative_regulation denotes inhibitor
T13905 18749-18758 Negative_regulation denotes inhibitor
T13904 18749-18758 Negative_regulation denotes inhibitor
T13903 18749-18758 Negative_regulation denotes inhibitor
T13902 18749-18758 Negative_regulation denotes inhibitor
T13901 18749-18758 Negative_regulation denotes inhibitor
T13900 18680-18689 Localization denotes secretion
T13899 18680-18689 Localization denotes secretion
T13898 18680-18689 Localization denotes secretion
T13897 18680-18689 Localization denotes secretion
T13896 18656-18669 Negative_regulation denotes downregulated
T13895 18656-18669 Negative_regulation denotes downregulated
T13894 18616-18626 Negative_regulation denotes inhibitors
T13893 18820-18825 Protein denotes IL-17
T13892 18745-18748 Protein denotes p38
T8690 11910-11915 Protein denotes GAPDH
T8689 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8688 11497-11515 Protein denotes Taq DNA polymerase
T8687 11050-11058 Protein denotes anti-CD3
T8686 10920-10930 Protein denotes IL-17 mRNA
R481 T1142 T1144 themeOf phosphoinositide 3-kinase,production
R487 T1152 T1153 themeOf production,regulate
R488 T1157 T1158 themeOf IL-17,production
R489 T1158 T1159 themeOf production,regulation
R490 T1159 T1160 themeOf regulation,role
R491 T1166 T1170 themeOf IL-17,production
R492 T1170 T1171 themeOf production,increased
R493 T1172 T1179 causeOf "IL-15, monocyte chemoattractant protein-1",upregulated
R494 T1173 T1180 causeOf IL-6,upregulated
R495 T1174 T1178 themeOf IL-17,production
R496 T1178 T1179 themeOf production,upregulated
R497 T1178 T1180 themeOf production,upregulated
R498 T1181 T1183 themeOf IL-17,detected
R499 T1182 T1184 themeOf RA PBMC,expression
R500 T1185 T1190 causeOf Anti-CD3 antibody,activated
R501 T1186 T1190 themeOf PI3K,activated
R502 T1188 T1191 themeOf nuclear factor κB,augmentation
R503 T1189 T1192 themeOf NF-κB,augmentation
R504 T1193 T1197 themeOf RA PBMC,production
R505 T1193 T1198 themeOf RA PBMC,activated
R506 T1195 T1201 themeOf PI3K,inhibitor
R507 T1196 T1202 themeOf Akt,inhibitor
R508 T1197 T1199 themeOf production,activated
R509 T1197 T1200 themeOf production,blocked
R510 T1203 T1206 themeOf activator protein-1,inhibition
R511 T1204 T1207 themeOf extracellular signal-regulated kinase 1/2,inhibition
R512 T1205 T1208 themeOf IL-17,production
R513 T1206 T1209 causeOf inhibition,affect
R514 T1207 T1210 causeOf inhibition,affect
R515 T1208 T1209 themeOf production,affect
R516 T1208 T1210 themeOf production,affect
R517 T1214 T1215 themeOf cytokine IL-17,overproduction
R1751 T3601 T3603 themeOf tumor necrosis factor (TNF)-α,inhibitors
R1753 T3602 T3604 themeOf interleukin (IL)-1,inhibitors
R1754 T3607 T3613 themeOf IL-1,abundant
R1757 T3608 T3614 themeOf IL-6,abundant
R1758 T3609 T3615 themeOf IL-15,abundant
R1759 T3610 T3616 themeOf IL-18,abundant
R1760 T3611 T3617 themeOf TNF-α,abundant
R1761 T3612 T3618 themeOf rheumatoid synovium,abundant
R1762 T3620 T3623 themeOf IL-17,secreted
R1763 T3620 T3626 causeOf IL-17,induce
R1764 T3620 T3627 causeOf IL-17,induce
R1765 T3621 T3624 themeOf IL-6,secreted
R1766 T3621 T3626 themeOf IL-6,induce
R1767 T3622 T3625 themeOf IL-8,secreted
R1768 T3622 T3627 themeOf IL-8,induce
R1769 T3633 T3634 themeOf IL-6,production
R1770 T3634 T3635 themeOf production,stimulates
R1771 T3636 T3638 themeOf IL-17,Levels
R1772 T3638 T3639 themeOf Levels,higher
R1773 T3640 T3641 themeOf IL-15,secreted
R1774 T3645 T3646 themeOf IL-17,production
R1775 T3651 T3652 themeOf cytokine IL-17,overproduction
R2966 T5569 T5571 themeOf Phytohemagglutinin,obtained
R2967 T5570 T5572 themeOf PHA,obtained
R4481 T8696 T8697 themeOf GAPDH,product
R5066 T9629 T9631 themeOf Akt,phosphorylated
R5067 T9632 T9635 themeOf Akt,phosphorylated
R5068 T9633 T9636 themeOf Akt,phosphorylated
R5069 T9634 T9637 themeOf IκB-α,phosphorylated
R6145 T11390 T11392 themeOf IL-17,production
R6146 T11392 T11393 themeOf production,stimulated
R6497 T11980 T11982 themeOf CD3,production
R6498 T11981 T11983 themeOf CD28,production
R6499 T11982 T11984 themeOf production,Increased
R6500 T11983 T11985 themeOf production,Increased
R6501 T11986 T11988 themeOf IL-17,produced
R6502 T11987 T11989 themeOf IL-17,increase
R6503 T11992 T12001 causeOf anti-CD3,upregulated
R6504 T11993 T11998 themeOf IL-17,production
R6505 T11996 T11999 themeOf more IL-17,produced
R6506 T11997 T12000 themeOf CD3,produced
R6507 T11998 T12001 themeOf production,upregulated
R6508 T12003 T12006 themeOf IL-17,production
R6509 T12004 T12007 themeOf anti-CD3,than
R6510 T12006 T12008 themeOf production,increased
R6980 T12874 T12875 themeOf IL-17,production
R6981 T12875 T12876 themeOf production,Regulation
R6982 T12879 T12884 themeOf IL-1β,unchanged
R6983 T12879 T12886 themeOf IL-1β,unchanged
R6984 T12879 T12888 themeOf IL-1β,unchanged
R6985 T12880 T12884 causeOf TNF-α,unchanged
R6986 T12880 T12885 causeOf TNF-α,unchanged
R6987 T12881 T12886 causeOf IL-18,unchanged
R6988 T12881 T12887 causeOf IL-18,unchanged
R6989 T12882 T12888 causeOf TGF-β,unchanged
R6990 T12882 T12889 causeOf TGF-β,unchanged
R6991 T12883 T12885 themeOf Fig. 2a,unchanged
R6992 T12883 T12887 themeOf Fig. 2a,unchanged
R6993 T12883 T12889 themeOf Fig. 2a,unchanged
R6994 T12891 T12895 themeOf IL-17 proteins,upregulations
R7557 T13877 T13878 themeOf IL-17,production
R7558 T13878 T13879 themeOf production,Inhibition
R7559 T13882 T13884 themeOf NF-κB,inhibitor
R7560 T13885 T13887 themeOf PI3K,inhibitor
R7561 T13888 T13894 themeOf calcineurin,inhibitors
R7562 T13889 T13897 themeOf IL-17,secretion
R7563 T13890 T13895 themeOf mitogen-activated protein kinase,downregulated
R7564 T13890 T13898 themeOf mitogen-activated protein kinase,secretion
R7565 T13890 T13901 themeOf mitogen-activated protein kinase,inhibitor
R7566 T13891 T13899 themeOf MAPK,secretion
R7567 T13891 T13902 themeOf MAPK,inhibitor
R7568 T13892 T13896 themeOf p38,downregulated
R7569 T13892 T13900 themeOf p38,secretion
R7570 T13892 T13903 themeOf p38,inhibitor
R7571 T13893 T13908 themeOf IL-17,effect
R7572 T13894 T13895 causeOf inhibitors,downregulated
R7573 T13894 T13896 causeOf inhibitors,downregulated
R7574 T13894 T13909 causeOf inhibitors,downregulated
R7575 T13894 T13910 causeOf inhibitors,downregulated
R7576 T13894 T13911 causeOf inhibitors,downregulated
R7577 T13894 T13912 causeOf inhibitors,downregulated
R7578 T13897 T13904 themeOf secretion,inhibitor
R7579 T13897 T13909 themeOf secretion,downregulated
R7580 T13898 T13905 themeOf secretion,inhibitor
R7581 T13898 T13910 themeOf secretion,downregulated
R7582 T13899 T13906 themeOf secretion,inhibitor
R7583 T13899 T13911 themeOf secretion,downregulated
R7584 T13900 T13907 themeOf secretion,inhibitor
R7585 T13900 T13912 themeOf secretion,downregulated
R7586 T13913 T13914 themeOf IL-17,production
R7587 T13914 T13915 themeOf production,inhibition
R7588 T13917 T13918 themeOf Fig. 4b,effects
R8323 T15147 T15149 themeOf PI3K,Activation
R8324 T15148 T15150 themeOf Akt,Activation
R8325 T15152 T15153 themeOf Akt,activation
R8326 T15155 T15156 themeOf Akt,phosphorylated
R8327 T15157 T15159 themeOf Akt,non-phosphorylated
R8328 T15158 T15160 themeOf β-actin,non-phosphorylated
R8329 T15164 T15166 themeOf Akt,phosphorylated
R8837 T16201 T16205 themeOf NF-κB,Activation
R8838 T16202 T16206 themeOf activator protein-1,Activation
R8839 T16203 T16207 themeOf AP-1,Activation
R8840 T16213 T16216 themeOf IL-17,expression
R8841 T16216 T16217 themeOf expression,inducing
R8842 T16219 T16224 themeOf RA PBMC,stimulated
R8843 T16220 T16225 themeOf anti-CD3,stimulated
R8844 T16221 T16224 causeOf anti-CD28,stimulated
R8845 T16221 T16225 causeOf anti-CD28,stimulated
R8846 T16222 T16226 themeOf NF-κB,binding
R8847 T16222 T16227 themeOf NF-κB,binding
R8848 T16223 T16227 themeOf IL-17 promoters,binding
R8849 T16226 T16228 themeOf binding,increased
R8850 T16227 T16229 themeOf binding,increased
R8851 T16232 T16237 themeOf NF-κB,activation
R8852 T16232 T16238 themeOf NF-κB,activation
R8853 T16233 T16237 causeOf anti-CD3,activation
R8854 T16234 T16238 causeOf anti-CD28,activation
R8855 T16235 T16239 themeOf RA PBMC,intense
R8856 T16242 T16243 themeOf NF-κB,binding
R8857 T16245 T16247 themeOf IL-17 promoter,block
R8858 T16246 T16248 themeOf Fig. 7c,block
R8859 T16250 T16252 themeOf IκB-α,degradation
R8860 T16252 T16253 themeOf degradation,inhibition
R10483 T19626 T19630 themeOf IL-17,production
R10484 T19627 T19631 themeOf IL-17,production
R10485 T19630 T19632 themeOf production,stimulate
R10486 T19636 T19637 themeOf IL-17,upregulation
R10487 T19638 T19640 themeOf IL-17,produced
R10488 T19642 T19644 themeOf type II collagen,recognizing
R10489 T19644 T19645 themeOf recognizing,augmented
R10490 T19646 T19649 themeOf IL-6,secrete
R10491 T19647 T19650 themeOf IL-8,secrete
R10492 T19648 T19651 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10493 T19652 T19653 themeOf IL-17,production
R10494 T19653 T19654 themeOf production,stimulate
R10495 T19655 T19661 themeOf IL-17,production
R10496 T19656 T19662 themeOf RA PBMC,production
R10497 T19657 T19663 themeOf T cell receptor,ligation
R10498 T19658 T19664 themeOf TCR,ligation
R10499 T19665 T19671 themeOf IL-15,ligation
R10500 T19665 T19674 causeOf IL-15,increased
R10501 T19665 T19675 causeOf IL-15,increased
R10502 T19666 T19676 causeOf MCP-1,increased
R10503 T19666 T19677 causeOf MCP-1,increased
R10504 T19667 T19670 themeOf TCR,ligation
R10505 T19667 T19671 themeOf TCR,ligation
R10506 T19668 T19672 themeOf IL-17,production
R10507 T19669 T19673 themeOf RA PBMC,production
R10508 T19670 T19678 causeOf ligation,increased
R10509 T19670 T19679 causeOf ligation,increased
R10510 T19671 T19680 causeOf ligation,increased
R10511 T19671 T19681 causeOf ligation,increased
R10512 T19672 T19674 themeOf production,increased
R10513 T19672 T19676 themeOf production,increased
R10514 T19672 T19678 themeOf production,increased
R10515 T19672 T19680 themeOf production,increased
R10516 T19673 T19675 themeOf production,increased
R10517 T19673 T19677 themeOf production,increased
R10518 T19673 T19679 themeOf production,increased
R10519 T19673 T19681 themeOf production,increased
R10520 T19684 T19685 themeOf TCR,ligation
R10521 T19686 T19690 causeOf IL-1,affect
R10522 T19687 T19691 causeOf TNF-α,affect
R10523 T19688 T19689 themeOf IL-17,production
R10524 T19689 T19690 themeOf production,affect
R10525 T19689 T19691 themeOf production,affect
R10526 T19696 T19698 themeOf IL-17,induction
R10527 T19697 T19699 themeOf RA PBMC,induction
R10528 T19698 T19700 themeOf induction,increases
R10529 T19699 T19701 themeOf induction,increases
R10530 T19703 T19704 themeOf IL-17,production
R10531 T19704 T19705 themeOf production,regulated
R10532 T19707 T19708 themeOf RA PBMC,induction
R10533 T19709 T19716 causeOf CD3,induced
R10534 T19710 T19714 themeOf RA PBMC,production
R10535 T19712 T19715 causeOf LY294002,hampered
R10536 T19714 T19715 themeOf production,hampered
R10537 T19714 T19716 themeOf production,induced
R10538 T19718 T19719 themeOf p38 MAPK,inhibitor
R10539 T19722 T19727 themeOf IκB kinase-β,activated
R10540 T19723 T19728 themeOf p38,activated
R10541 T19724 T19729 themeOf NF-κB,stimulate
R10542 T19726 T19730 themeOf CREB,binding
R10543 T19728 T19729 causeOf activated,stimulate
R10544 T19731 T19735 themeOf p38 MAPK,activation
R10545 T19732 T19737 themeOf NF-κB,binding
R10546 T19734 T19739 themeOf PI3K,activation
R10547 T19735 T19736 themeOf activation,affected
R10548 T19737 T19738 themeOf binding,decreased
R10549 T19742 T19743 themeOf IL-17,production
R10550 T19745 T19746 themeOf Akt,activation
R10551 T19746 T19747 themeOf activation,loss
R10552 T19748 T19752 themeOf Akt,phosphorylated
R10553 T19750 T19754 causeOf PI3K,involvement
R10554 T19751 T19753 themeOf IL-17,induction
R10555 T19753 T19754 themeOf induction,involvement
R10556 T19755 T19762 themeOf NF-κB,activated
R10557 T19755 T19763 themeOf NF-κB,activated
R10558 T19755 T19764 themeOf NF-κB,activated
R10559 T19756 T19762 causeOf anti-CD3,activated
R10560 T19757 T19763 causeOf anti-CD28,activated
R10561 T19758 T19764 causeOf IL-15,activated
R10562 T19759 T19767 causeOf NF-κB,involved
R10563 T19759 T19768 causeOf NF-κB,involved
R10564 T19760 T19765 themeOf IL-17,induction
R10565 T19761 T19766 themeOf RA PBMC,induction
R10566 T19765 T19767 themeOf induction,involved
R10567 T19766 T19768 themeOf induction,involved
R10568 T19771 T19775 themeOf Akt,association
R10569 T19772 T19774 themeOf NF-κB,association
R10570 T19772 T19775 themeOf NF-κB,association
R10571 T19777 T19784 themeOf Akt,binding
R10572 T19778 T19781 themeOf NF-κB,activation
R10573 T19779 T19782 themeOf NF-κB,binding
R10574 T19779 T19784 themeOf NF-κB,binding
R10575 T19779 T19785 themeOf NF-κB,binding
R10576 T19780 T19783 themeOf IL-17 promoter,binding
R10577 T19780 T19785 themeOf IL-17 promoter,binding
R10578 T19782 T19786 themeOf binding,blocking
R10579 T19783 T19787 themeOf binding,blocking
R10580 T19784 T19788 themeOf binding,blocking
R10581 T19785 T19789 themeOf binding,blocking
R10582 T19790 T19792 themeOf anti-IL-17,induction
R12199 T22367 T22373 themeOf IL-17,production
R12200 T22368 T22374 themeOf RA PBMC,production
R12201 T22369 T22375 themeOf IL-15,response
R12202 T22370 T22376 themeOf MCP-1,response
R12203 T22377 T22381 themeOf IL-17,upregulation
R12204 T22380 T22382 themeOf NF-κB,activation
R12205 T22383 T22384 themeOf anti-IL-17,introduction
R482 T1143 T1145 themeOf Akt,production
R483 T1144 T1146 themeOf production,Increased
R484 T1145 T1147 themeOf production,Increased
R485 T1149 T1150 themeOf IL-17,expression
R486 T1151 T1152 themeOf IL-17,production

testone

Id Subject Object Predicate Lexical cue
T36 10-24 Protein denotes interleukin-17
T37 68-71 Protein denotes Akt
T71 0-9 Positive_regulation denotes Increased
T72 25-35 Gene_expression denotes production
T22070 28503-28513 Gene_expression denotes production
T22069 28483-28493 Regulation denotes regulation
T22068 28270-28282 Positive_regulation denotes upregulation
T22067 28169-28183 Positive_regulation denotes in response to
T22066 28136-28146 Gene_expression denotes production
T22065 28675-28680 Protein denotes IL-17
T22064 28497-28502 Protein denotes IL-17
T22063 28380-28383 Protein denotes Akt
T22062 28286-28291 Protein denotes IL-17
T22061 28240-28244 Protein denotes CD28
T22060 28194-28199 Protein denotes MCP-1
T22059 28184-28189 Protein denotes IL-15
T22058 28150-28155 Protein denotes IL-17
T17026 27808-27816 Entity denotes promoter
T17025 27778-27785 Binding denotes binding
T17024 27760-27768 Negative_regulation denotes blocking
T17023 27678-27690 Positive_regulation denotes upregulation
T17022 27554-27561 Negative_regulation denotes lacking
T17021 27535-27543 Positive_regulation denotes inducing
T17020 27420-27431 Binding denotes association
T17019 27174-27183 Positive_regulation denotes induction
T17018 27158-27166 Regulation denotes involved
T17017 26963-26972 Positive_regulation denotes induction
T17016 26936-26947 Regulation denotes involvement
T17015 26873-26887 Phosphorylation denotes phosphorylated
T17014 26788-26798 Positive_regulation denotes activation
T17013 26649-26659 Gene_expression denotes production
T17012 26487-26496 Negative_regulation denotes decreased
T17011 26466-26473 Binding denotes binding
T17010 26430-26438 Regulation denotes affected
T17009 26267-26276 Positive_regulation denotes activated
T17008 26236-26245 Positive_regulation denotes activated
T17007 26110-26119 Negative_regulation denotes inhibitor
T17006 26056-26069 Negative_regulation denotes downregulated
T17005 26041-26051 Gene_expression denotes production
T17004 26027-26034 Positive_regulation denotes induced
T17003 25967-25977 Gene_expression denotes production
T17002 25868-25876 Negative_regulation denotes hampered
T17001 25828-25838 Gene_expression denotes production
T17000 25814-25821 Positive_regulation denotes induced
T16999 25755-25764 Positive_regulation denotes induction
T16998 25739-25747 Regulation denotes involved
T16997 25600-25609 Regulation denotes regulated
T16996 25582-25592 Gene_expression denotes production
T16995 25399-25408 Positive_regulation denotes induction
T16994 25383-25392 Positive_regulation denotes increases
T16993 25056-25066 Gene_expression denotes production
T16992 25031-25040 Positive_regulation denotes triggered
T16991 24962-24972 Gene_expression denotes production
T16990 24949-24955 Regulation denotes affect
T16989 24917-24926 Positive_regulation denotes increased
T16988 24801-24811 Gene_expression denotes production
T16987 24785-24794 Positive_regulation denotes augmented
T16986 24715-24725 Gene_expression denotes production
T16985 24701-24710 Positive_regulation denotes increased
T16984 24457-24467 Gene_expression denotes production
T16983 24398-24408 Gene_expression denotes production
T16982 24383-24391 Regulation denotes regulate
T16981 24304-24314 Gene_expression denotes production
T16980 24288-24297 Positive_regulation denotes stimulate
T16979 23770-23779 Positive_regulation denotes augmented
T16978 23741-23751 Gene_expression denotes production
T16977 23620-23628 Gene_expression denotes produced
T16976 23495-23503 Gene_expression denotes produced
T16975 23381-23393 Positive_regulation denotes upregulation
T16974 23295-23304 Regulation denotes dependent
T16973 23261-23271 Gene_expression denotes production
T16972 23245-23254 Positive_regulation denotes increased
T16971 23045-23055 Gene_expression denotes production
T16970 22991-23001 Gene_expression denotes production
T16969 22975-22984 Positive_regulation denotes stimulate
T16968 22766-22775 Regulation denotes regulated
T16967 22752-22762 Gene_expression denotes production
T16966 27996-28001 Protein denotes IL-17
T16965 27915-27920 Protein denotes IL-17
T16964 27802-27807 Protein denotes IL-17
T16963 27694-27699 Protein denotes IL-17
T16962 27603-27606 Protein denotes Akt
T16961 27544-27549 Protein denotes IL-17
T16960 27413-27416 Protein denotes Akt
T16959 27222-27226 Protein denotes AP-1
T16958 27187-27192 Protein denotes IL-17
T16957 27062-27067 Protein denotes IL-15
T16956 27056-27060 Protein denotes CD28
T16955 26976-26981 Protein denotes IL-17
T16954 26866-26869 Protein denotes Akt
T16953 26784-26787 Protein denotes Akt
T16952 26643-26648 Protein denotes IL-17
T16951 26349-26369 Protein denotes CREB-binding protein
T16950 26344-26348 Protein denotes p300
T16949 26220-26232 Protein denotes IκB kinase-β
T16948 26035-26040 Protein denotes IL-17
T16947 25822-25827 Protein denotes IL-17
T16946 25810-25813 Protein denotes CD3
T16945 25768-25773 Protein denotes IL-17
T16944 25576-25581 Protein denotes IL-17
T16943 25497-25502 Protein denotes IL-17
T16942 25393-25398 Protein denotes IL-17
T16941 25373-25377 Protein denotes CD28
T16940 25139-25144 Protein denotes MCP-1
T16939 25080-25085 Protein denotes TNF-α
T16938 25050-25055 Protein denotes IL-17
T16937 25025-25030 Protein denotes IL-15
T16936 24956-24961 Protein denotes IL-17
T16935 24849-24854 Protein denotes TNF-α
T16934 24840-24844 Protein denotes IL-1
T16933 24795-24800 Protein denotes IL-17
T16932 24763-24768 Protein denotes MCP-1
T16931 24754-24759 Protein denotes IL-15
T16930 24729-24734 Protein denotes IL-17
T16929 24657-24662 Protein denotes MCP-1
T16928 24647-24652 Protein denotes IL-15
T16927 24611-24615 Protein denotes CD28
T16926 24471-24476 Protein denotes IL-17
T16925 24392-24397 Protein denotes IL-17
T16924 24357-24362 Protein denotes IL-23
T16923 24347-24352 Protein denotes IL-15
T16922 24298-24303 Protein denotes IL-17
T16921 24144-24183 Protein denotes tumor necrosis factor-stimulated gene 6
T16920 24135-24139 Protein denotes IL-8
T16919 24129-24133 Protein denotes IL-6
T16918 24051-24056 Protein denotes IL-17
T16917 23735-23740 Protein denotes IL-17
T16916 23652-23657 Protein denotes IL-23
T16915 23632-23635 Protein denotes CD8
T16914 23524-23527 Protein denotes CD4
T16913 23486-23491 Protein denotes IL-17
T16912 23397-23402 Protein denotes IL-17
T16911 23255-23260 Protein denotes IL-17
T16910 23197-23201 Protein denotes CD28
T16909 23155-23158 Protein denotes PHA
T16908 23089-23093 Protein denotes CD28
T16907 23039-23044 Protein denotes IL-17
T16906 22985-22990 Protein denotes IL-17
T16905 22835-22840 Protein denotes IL-17
T16904 22746-22751 Protein denotes IL-17
T16903 22594-22599 Protein denotes IL-17
T16902 22349-22361 Protein denotes interferon-γ
T16901 22340-22344 Protein denotes IL-4
T16900 22248-22253 Protein denotes TNF-α
T16899 22239-22243 Protein denotes IL-1
T16898 22004-22009 Protein denotes IL-17
T15531 21954-21963 Positive_regulation denotes activated
T15530 21940-21950 Gene_expression denotes production
T15529 21682-21693 Protein_catabolism denotes degradation
T15528 21668-21678 Negative_regulation denotes inhibition
T15527 21584-21591 Binding denotes binding
T15526 21568-21573 Negative_regulation denotes block
T15525 21494-21501 Binding denotes binding
T15524 21061-21068 Binding denotes binding
T15523 21051-21060 Positive_regulation denotes increased
T15522 20812-20822 Gene_expression denotes expression
T15521 20797-20805 Positive_regulation denotes inducing
T15520 20781-20792 Regulation denotes responsible
T15519 21934-21939 Protein denotes IL-17
T15518 21839-21843 Protein denotes CD28
T15517 21769-21773 Protein denotes AP-1
T15516 21697-21702 Protein denotes IκB-α
T15515 21655-21660 Protein denotes IκB-α
T15514 21608-21613 Protein denotes IL-17
T15513 21346-21350 Protein denotes CD28
T15512 21227-21232 Protein denotes c-Rel
T15511 21200-21203 Protein denotes p50
T15510 21192-21195 Protein denotes p65
T15509 21081-21086 Protein denotes IL-17
T15508 21024-21028 Protein denotes CD28
T15507 20931-20936 Protein denotes IL-17
T15506 20806-20811 Protein denotes IL-17
T15505 20770-20775 Protein denotes IL-15
T15504 20762-20765 Protein denotes PHA
T15503 20740-20744 Protein denotes CD28
T15502 20627-20632 Protein denotes IL-17
T15501 20606-20610 Protein denotes AP-1
T15500 20585-20604 Protein denotes activator protein-1
T14737 20481-20491 Negative_regulation denotes inhibition
T14736 20425-20439 Phosphorylation denotes phosphorylated
T14735 20415-20421 Regulation denotes effect
T14734 20277-20291 Phosphorylation denotes phosphorylated
T14733 20140-20149 Positive_regulation denotes increased
T14732 20121-20135 Phosphorylation denotes phosphorylated
T14731 20051-20065 Phosphorylation denotes phosphorylated
T14730 20022-20032 Regulation denotes difference
T14729 19890-19900 Positive_regulation denotes activation
T14728 19786-19796 Gene_expression denotes production
T14727 20440-20443 Protein denotes Akt
T14726 20382-20387 Protein denotes IL-15
T14725 20358-20361 Protein denotes PHA
T14724 20300-20307 Protein denotes β-actin
T14723 20292-20295 Protein denotes Akt
T14722 20136-20139 Protein denotes Akt
T14721 20066-20069 Protein denotes Akt
T14720 19904-19907 Protein denotes Akt
T14719 19780-19785 Protein denotes IL-17
T14718 19745-19748 Protein denotes Akt
T14420 19642-19651 Negative_regulation denotes inhibited
T14419 19588-19599 Transcription denotes transcripts
T14418 19583-19587 Transcription denotes mRNA
T14417 19565-19573 Positive_regulation denotes increase
T14416 19555-19564 Regulation denotes dependent
T14415 19417-19426 Regulation denotes regulated
T14414 19397-19407 Gene_expression denotes production
T14413 19382-19390 Positive_regulation denotes enhanced
T14412 19340-19355 Transcription denotes mRNA expression
T14411 19577-19582 Protein denotes IL-17
T14410 19391-19396 Protein denotes IL-17
T14409 19334-19339 Protein denotes IL-17
T13329 19105-19115 Negative_regulation denotes inhibitors
T13328 19080-19090 Gene_expression denotes production
T13327 19059-19070 Negative_regulation denotes inhibitions
T13326 19013-19023 Gene_expression denotes production
T13325 18993-19003 Negative_regulation denotes inhibition
T13324 18810-18816 Regulation denotes effect
T13323 18749-18758 Negative_regulation denotes inhibitor
T13322 18680-18689 Localization denotes secretion
T13321 18656-18669 Negative_regulation denotes downregulated
T13320 18492-18502 Gene_expression denotes production
T13319 18478-18485 Positive_regulation denotes induced
T13318 18455-18464 Negative_regulation denotes inhibited
T13317 18203-18213 Gene_expression denotes production
T13316 18189-18196 Positive_regulation denotes induced
T13315 18168-18176 Negative_regulation denotes decrease
T13314 18029-18039 Gene_expression denotes production
T13313 18013-18022 Positive_regulation denotes increased
T13312 17923-17933 Gene_expression denotes production
T13311 17903-17913 Negative_regulation denotes Inhibition
T13310 19074-19079 Protein denotes IL-17
T13309 19007-19012 Protein denotes IL-17
T13308 18820-18825 Protein denotes IL-17
T13307 18674-18679 Protein denotes IL-17
T13306 18604-18615 Protein denotes calcineurin
T13305 18486-18491 Protein denotes IL-17
T13304 18197-18202 Protein denotes IL-17
T13303 18023-18028 Protein denotes IL-17
T13302 17917-17922 Protein denotes IL-17
T11645 16862-16872 Gene_expression denotes production
T11644 16846-16855 Positive_regulation denotes increased
T11643 16714-16722 Gene_expression denotes produced
T11642 16641-16651 Gene_expression denotes production
T11641 16623-16634 Positive_regulation denotes upregulated
T11640 16451-16459 Positive_regulation denotes increase
T11639 16272-16280 Gene_expression denotes produced
T11638 16136-16146 Gene_expression denotes production
T11637 16120-16129 Positive_regulation denotes Increased
T11636 16921-16925 Protein denotes CD28
T11635 16856-16861 Protein denotes IL-17
T11634 16841-16844 Protein denotes PHA
T11633 16728-16733 Protein denotes IL-17
T11632 16696-16700 Protein denotes CD28
T12407 17426-17434 Positive_regulation denotes increase
T12406 17399-17409 Gene_expression denotes production
T12405 17220-17230 Gene_expression denotes production
T12404 17207-17215 Regulation denotes affected
T12403 16990-17000 Gene_expression denotes production
T12402 16970-16980 Regulation denotes Regulation
T12401 17873-17879 Protein denotes MIP-1β
T12400 17852-17858 Protein denotes MIP-1α
T12399 17835-17839 Protein denotes IL-8
T12398 17707-17712 Protein denotes IL-17
T12397 17661-17665 Protein denotes IL-6
T12396 17641-17646 Protein denotes MCP-1
T12395 17591-17596 Protein denotes IL-17
T12394 17560-17565 Protein denotes TGF-β
T12393 17540-17545 Protein denotes IL-18
T12392 17522-17527 Protein denotes TNF-α
T12391 17504-17509 Protein denotes IL-1β
T12390 17473-17478 Protein denotes IL-15
T12389 17438-17443 Protein denotes IL-17
T12388 17393-17398 Protein denotes IL-17
T12387 17234-17239 Protein denotes IL-17
T12386 16984-16989 Protein denotes IL-17
T11631 16635-16640 Protein denotes IL-17
T11630 16463-16468 Protein denotes IL-17
T11629 16221-16226 Protein denotes IL-17
T11628 16209-16212 Protein denotes PHA
T11627 16199-16203 Protein denotes CD28
T11626 16130-16135 Protein denotes IL-17
T11094 15988-15994 Positive_regulation denotes higher
T11093 15952-15962 Positive_regulation denotes stimulated
T11092 15941-15951 Gene_expression denotes production
T11091 15815-15824 Localization denotes secretion
T11090 15499-15509 Gene_expression denotes production
T11089 15966-15969 Protein denotes PHA
T11088 15935-15940 Protein denotes IL-17
T11087 15809-15814 Protein denotes IL-17
T11086 15707-15712 Protein denotes IL-17
T11085 15619-15622 Protein denotes PHA
T11084 15493-15498 Protein denotes IL-17
T9981 14837-14842 Protein denotes c-Rel
T9980 14829-14832 Protein denotes p65
T9979 14824-14827 Protein denotes p50
T9978 13930-13935 Protein denotes IL-17
T9204 13281-13295 Phosphorylation denotes phosphorylated
T9203 12526-12540 Phosphorylation denotes phosphorylated
T9202 13304-13309 Protein denotes IκB-α
T9201 13296-13299 Protein denotes Akt
T9200 13276-13279 Protein denotes Akt
T9199 12549-12554 Protein denotes IκB-α
T9198 12541-12544 Protein denotes Akt
T9197 12521-12524 Protein denotes Akt
T8193 12413-12428 Transcription denotes mRNA expression
T8192 12480-12485 Protein denotes GAPDH
T8191 12457-12462 Protein denotes IL-17
T8190 12297-12302 Protein denotes IL-17
T8189 12287-12292 Protein denotes GAPDH
T8188 12186-12191 Protein denotes IL-17
T8187 12176-12181 Protein denotes GAPDH
T8186 11957-11962 Protein denotes GAPDH
T8185 11910-11915 Protein denotes GAPDH
T8184 11868-11908 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T8183 11760-11765 Protein denotes IL-17
T8182 11497-11500 Protein denotes Taq
T8181 10920-10925 Protein denotes IL-17
T7244 10878-10883 Protein denotes IL-17
T7243 10631-10636 Protein denotes IL-17
T7242 10583-10588 Protein denotes IL-17
T7241 10140-10145 Protein denotes IL-17
T7240 9885-9890 Protein denotes IL-17
T7239 9669-9674 Protein denotes IL-17
T7238 9463-9468 Protein denotes IL-17
T7237 9457-9462 Protein denotes IL-17
T6528 9400-9403 Protein denotes CD4
T6527 9052-9055 Protein denotes CD4
T6526 8506-8509 Protein denotes CD4
T6525 8357-8360 Protein denotes CD4
T6524 8322-8325 Protein denotes CD4
T5912 7291-7301 Gene_expression denotes Production
T5911 7305-7310 Protein denotes IL-17
T5238 7106-7110 Protein denotes CD28
T5237 6921-6924 Protein denotes PHA
T5236 6901-6919 Protein denotes Phytohemagglutinin
T5235 6777-6781 Protein denotes IL-1
T5234 6767-6772 Protein denotes TNF-α
T5233 6677-6711 Protein denotes transforming growth factor (TGF)-β
T5232 6602-6606 Protein denotes IL-8
T5231 6593-6597 Protein denotes IL-6
T5230 6585-6591 Protein denotes MIP-1β
T5229 6543-6583 Protein denotes macrophage inflammatory protein (MIP)-1α
T5228 6535-6540 Protein denotes MCP-1
T5227 6499-6533 Protein denotes monocyte chemoattractant protein-1
T5226 6492-6497 Protein denotes IL-15
T5225 6485-6490 Protein denotes IL-18
T5224 6478-6483 Protein denotes IL-17
T2153 5458-5472 Gene_expression denotes overproduction
T2152 5442-5450 Regulation denotes involved
T2151 5247-5257 Gene_expression denotes production
T2150 5151-5161 Gene_expression denotes production
T2149 4932-4942 Gene_expression denotes production
T2148 4915-4922 Positive_regulation denotes trigger
T2147 4726-4736 Gene_expression denotes production
T2146 4709-4716 Positive_regulation denotes trigger
T2145 4578-4586 Gene_expression denotes produced
T2144 4240-4250 Gene_expression denotes production
T2143 4225-4235 Positive_regulation denotes stimulates
T2142 4095-4104 Positive_regulation denotes induction
T2141 3972-3980 Gene_expression denotes produced
T2140 3791-3797 Positive_regulation denotes induce
T2139 5506-5511 Protein denotes IL-17
T2138 5419-5422 Protein denotes Akt
T2137 5241-5246 Protein denotes IL-17
T2136 5145-5150 Protein denotes IL-17
T2135 5010-5015 Protein denotes IL-17
T2134 4962-4965 Protein denotes CD8
T2133 4953-4956 Protein denotes CD4
T2132 4926-4931 Protein denotes IL-17
T2131 4887-4892 Protein denotes IL-23
T2130 4720-4725 Protein denotes IL-17
T2129 4628-4633 Protein denotes IL-15
T2128 4590-4593 Protein denotes CD4
T2127 4453-4458 Protein denotes IL-17
T2126 4263-4289 Protein denotes leukemia inhibitory factor
T2125 4254-4258 Protein denotes IL-6
T2124 4115-4169 Protein denotes receptor activator of nuclear factor κB [NF-κB] ligand
T2123 4108-4113 Protein denotes RANKL
T2122 4035-4040 Protein denotes IL-17
T2121 3920-3925 Protein denotes IL-17
T2120 3914-3918 Protein denotes IL-1
T2119 3904-3909 Protein denotes TNF-α
T2118 3807-3811 Protein denotes IL-8
T2117 3798-3802 Protein denotes IL-6
T2116 3700-3705 Protein denotes IL-17
T2115 3325-3330 Protein denotes TNF-α
T2114 3315-3320 Protein denotes IL-18
T2113 3308-3313 Protein denotes IL-15
T2112 3302-3306 Protein denotes IL-6
T2111 3296-3300 Protein denotes IL-1
T2110 3208-3220 Protein denotes interferon-γ
T2109 3199-3203 Protein denotes IL-2
T2108 2762-2780 Protein denotes interleukin (IL)-1
T2107 2727-2756 Protein denotes tumor necrosis factor (TNF)-α
T42 648-653 Protein denotes IL-17
T41 610-615 Protein denotes IL-23
T40 600-605 Protein denotes IL-15
T39 504-509 Protein denotes IL-17
T38 273-292 Protein denotes Interleukin (IL)-17
T92 2345-2359 Gene_expression denotes overproduction
T91 2329-2337 Regulation denotes involved
T90 2225-2235 Gene_expression denotes production
T89 2212-2218 Regulation denotes affect
T88 2066-2075 Negative_regulation denotes inhibitor
T87 2011-2020 Negative_regulation denotes inhibitor
T86 1974-1981 Negative_regulation denotes blocked
T82 1500-1510 Gene_expression denotes production
T81 1482-1493 Positive_regulation denotes upregulated
T80 1296-1305 Positive_regulation denotes increased
T79 1258-1268 Gene_expression denotes production
T78 876-886 Gene_expression denotes production
T77 856-866 Regulation denotes regulation
T76 723-733 Gene_expression denotes production
T75 708-716 Regulation denotes regulate
T74 654-664 Gene_expression denotes production
T73 639-647 Regulation denotes regulate
T70 2393-2398 Protein denotes IL-17
T69 2311-2314 Protein denotes Akt
T68 2219-2224 Protein denotes IL-17
T67 2202-2203 Protein denotes 2
T66 2162-2201 Protein denotes extracellular signal-regulated kinase 1
T65 2138-2157 Protein denotes activator protein-1
T64 2062-2065 Protein denotes Akt
T63 1912-1917 Protein denotes IL-17
T62 1783-1786 Protein denotes Akt
T61 1610-1615 Protein denotes IL-17
T60 1572-1600 Protein denotes transforming growth factor-β
T59 1563-1568 Protein denotes IL-18
T58 1556-1561 Protein denotes IL-1β
T57 1531-1554 Protein denotes tumor necrosis factor-α
T56 1494-1499 Protein denotes IL-17
T55 1477-1481 Protein denotes IL-6
T54 1438-1472 Protein denotes monocyte chemoattractant protein-1
T53 1431-1436 Protein denotes IL-15
T52 1376-1379 Protein denotes PHA
T51 1367-1371 Protein denotes CD28
T50 1272-1277 Protein denotes IL-17
T49 1126-1131 Protein denotes IL-17
T48 1070-1073 Protein denotes PHA
T47 1050-1068 Protein denotes phytohemagglutinin
T46 1044-1048 Protein denotes CD28
T45 870-875 Protein denotes IL-17
T44 837-840 Protein denotes Akt
T43 717-722 Protein denotes IL-17
T85 1932-1941 Positive_regulation denotes activated
T84 1918-1928 Gene_expression denotes production
T83 1689-1699 Gene_expression denotes expression
R1 T36 T72 themeOf interleukin-17,production
R2 T41 T73 causeOf IL-23,regulate
R4 T43 T76 themeOf IL-17,production
R5 T45 T78 themeOf IL-17,production
R6 T48 T47 equivalentTo PHA,phytohemagglutinin
R7 T50 T79 themeOf IL-17,production
R8 T51 T80 causeOf CD28,increased
R9 T52 T80 causeOf PHA,increased
R10 T53 T81 causeOf IL-15,upregulated
R11 T54 T81 causeOf monocyte chemoattractant protein-1,upregulated
R12 T55 T81 causeOf IL-6,upregulated
R13 T56 T82 themeOf IL-17,production
R14 T61 T83 themeOf IL-17,expression
R15 T63 T84 themeOf IL-17,production
R16 T64 T88 themeOf Akt,inhibitor
R17 T68 T90 themeOf IL-17,production
R18 T70 T92 themeOf IL-17,overproduction
R19 T72 T71 themeOf production,Increased
R20 T74 T73 themeOf production,regulate
R21 T76 T75 themeOf production,regulate
R22 T78 T77 themeOf production,regulation
R23 T79 T80 themeOf production,increased
R24 T82 T81 themeOf production,upregulated
R25 T84 T86 themeOf production,blocked
R26 T87 T86 causeOf inhibitor,blocked
R27 T88 T86 causeOf inhibitor,blocked
R28 T90 T89 themeOf production,affect
R1068 T2116 T2140 causeOf IL-17,induce
R1069 T2117 T2140 themeOf IL-6,induce
R1070 T2118 T2140 themeOf IL-8,induce
R1071 T2119 T2141 themeOf TNF-α,produced
R1072 T2120 T2141 themeOf IL-1,produced
R1073 T2121 T2141 themeOf IL-17,produced
R1074 T2123 T2142 themeOf RANKL,induction
R1075 T2124 T2142 themeOf receptor activator of nuclear factor κB [NF-κB] ligand,induction
R1076 T2124 T2123 equivalentTo receptor activator of nuclear factor κB [NF-κB] ligand,RANKL
R1077 T2125 T2144 themeOf IL-6,production
R1078 T2126 T2144 themeOf leukemia inhibitory factor,production
R1079 T2127 T2145 themeOf IL-17,produced
R1080 T2130 T2147 themeOf IL-17,production
R1081 T2131 T2148 causeOf IL-23,trigger
R1082 T2132 T2149 themeOf IL-17,production
R1083 T2136 T2150 themeOf IL-17,production
R1084 T2137 T2151 themeOf IL-17,production
R1085 T2139 T2153 themeOf IL-17,overproduction
R1086 T2144 T2143 themeOf production,stimulates
R1087 T2147 T2146 themeOf production,trigger
R1088 T2149 T2148 themeOf production,trigger
R1089 T2153 T2152 themeOf overproduction,involved
R2805 T5228 T5227 equivalentTo MCP-1,monocyte chemoattractant protein-1
R2806 T5229 T5227 equivalentTo macrophage inflammatory protein (MIP)-1α,monocyte chemoattractant protein-1
R2807 T5237 T5236 equivalentTo PHA,Phytohemagglutinin
R3141 T5911 T5912 themeOf IL-17,Production
R4470 T8185 T8184 equivalentTo GAPDH,glyceraldehyde-3-phosphate dehydrogenase
R4471 T8191 T8193 themeOf IL-17,mRNA expression
R4472 T8192 T8193 themeOf GAPDH,mRNA expression
R4822 T9198 T9203 themeOf Akt,phosphorylated
R4823 T9199 T9203 themeOf IκB-α,phosphorylated
R4824 T9201 T9204 themeOf Akt,phosphorylated
R4825 T9202 T9204 themeOf IκB-α,phosphorylated
R5988 T11084 T11090 themeOf IL-17,production
R5989 T11087 T11091 themeOf IL-17,secretion
R5990 T11088 T11092 themeOf IL-17,production
R5991 T11089 T11093 causeOf PHA,stimulated
R5992 T11092 T11093 themeOf production,stimulated
R5993 T11092 T11094 themeOf production,higher
R6306 T11626 T11638 themeOf IL-17,production
R6307 T11628 T11637 causeOf PHA,Increased
R6308 T11629 T11639 themeOf IL-17,produced
R6309 T11630 T11640 themeOf IL-17,increase
R6310 T11631 T11642 themeOf IL-17,production
R6311 T11633 T11643 themeOf IL-17,produced
R6312 T11634 T11644 causeOf PHA,increased
R6313 T11635 T11645 themeOf IL-17,production
R6314 T11638 T11637 themeOf production,Increased
R6315 T11642 T11641 themeOf production,upregulated
R6316 T11645 T11644 themeOf production,increased
R6738 T12386 T12403 themeOf IL-17,production
R6739 T12387 T12405 themeOf IL-17,production
R6740 T12388 T12406 themeOf IL-17,production
R6741 T12389 T12407 themeOf IL-17,increase
R6742 T12390 T12407 causeOf IL-15,increase
R6743 T12391 T12407 causeOf IL-1β,increase
R6744 T12392 T12407 causeOf TNF-α,increase
R6745 T12393 T12407 causeOf IL-18,increase
R6746 T12394 T12407 causeOf TGF-β,increase
R6747 T12395 T12407 causeOf IL-17,increase
R6748 T12403 T12402 themeOf production,Regulation
R6749 T12405 T12404 themeOf production,affected
R7252 T13302 T13312 themeOf IL-17,production
R7253 T13303 T13314 themeOf IL-17,production
R7254 T13304 T13317 themeOf IL-17,production
R7255 T13305 T13320 themeOf IL-17,production
R7256 T13307 T13322 themeOf IL-17,secretion
R7257 T13308 T13324 causeOf IL-17,effect
R7258 T13309 T13326 themeOf IL-17,production
R7259 T13310 T13328 themeOf IL-17,production
R7260 T13312 T13311 themeOf production,Inhibition
R7261 T13314 T13313 themeOf production,increased
R7262 T13316 T13315 themeOf induced,decrease
R7263 T13317 T13316 themeOf production,induced
R7264 T13319 T13318 themeOf induced,inhibited
R7265 T13320 T13319 themeOf production,induced
R7266 T13322 T13321 themeOf secretion,downregulated
R7267 T13323 T13321 themeOf inhibitor,downregulated
R7268 T13326 T13325 themeOf production,inhibition
R7269 T13328 T13327 themeOf production,inhibitions
R7270 T13329 T13327 themeOf inhibitors,inhibitions
R7955 T14409 T14412 themeOf IL-17,mRNA expression
R7956 T14410 T14414 themeOf IL-17,production
R7957 T14411 T14417 themeOf IL-17,increase
R7958 T14414 T14415 themeOf production,regulated
R7959 T14414 T14413 themeOf production,enhanced
R7960 T14416 T14420 themeOf dependent,inhibited
R7961 T14417 T14420 themeOf increase,inhibited
R7962 T14417 T14416 themeOf increase,dependent
R7963 T14418 T14417 themeOf mRNA,increase
R7964 T14418 T14420 themeOf mRNA,inhibited
R8132 T14719 T14728 themeOf IL-17,production
R8133 T14720 T14729 themeOf Akt,activation
R8134 T14721 T14731 themeOf Akt,phosphorylated
R8135 T14722 T14732 themeOf Akt,phosphorylated
R8136 T14723 T14734 themeOf Akt,phosphorylated
R8137 T14724 T14734 themeOf β-actin,phosphorylated
R8138 T14725 T14735 causeOf PHA,effect
R8139 T14726 T14735 causeOf IL-15,effect
R8140 T14727 T14736 themeOf Akt,phosphorylated
R8141 T14736 T14735 themeOf phosphorylated,effect
R8542 T15501 T15500 equivalentTo AP-1,activator protein-1
R8543 T15504 T15521 causeOf PHA,inducing
R8544 T15505 T15521 causeOf IL-15,inducing
R8545 T15506 T15522 themeOf IL-17,expression
R8546 T15509 T15524 themeOf IL-17,binding
R8547 T15516 T15529 themeOf IκB-α,degradation
R8548 T15519 T15530 themeOf IL-17,production
R8549 T15521 T15520 themeOf inducing,responsible
R8550 T15522 T15521 themeOf expression,inducing
R8551 T15524 T15523 themeOf binding,increased
R8552 T15527 T15526 themeOf binding,block
R8553 T15529 T15528 themeOf degradation,inhibition
R9199 T16904 T16967 themeOf IL-17,production
R9200 T16906 T16970 themeOf IL-17,production
R9201 T16907 T16971 themeOf IL-17,production
R9202 T16909 T16972 causeOf PHA,increased
R9203 T16911 T16973 themeOf IL-17,production
R9204 T16912 T16975 themeOf IL-17,upregulation
R9205 T16913 T16976 themeOf IL-17,produced
R9206 T16916 T16977 causeOf IL-23,produced
R9207 T16917 T16978 themeOf IL-17,production
R9208 T16922 T16981 themeOf IL-17,production
R9209 T16924 T16982 causeOf IL-23,regulate
R9210 T16925 T16983 themeOf IL-17,production
R9211 T16926 T16984 themeOf IL-17,production
R9212 T16928 T16985 causeOf IL-15,increased
R9213 T16930 T16986 themeOf IL-17,production
R9214 T16931 T16987 causeOf IL-15,augmented
R9215 T16933 T16988 themeOf IL-17,production
R9216 T16934 T16990 causeOf IL-1,affect
R9217 T16934 T16989 themeOf IL-1,increased
R9218 T16935 T16989 themeOf TNF-α,increased
R9219 T16936 T16991 themeOf IL-17,production
R9220 T16937 T16992 causeOf IL-15,triggered
R9221 T16938 T16993 themeOf IL-17,production
R9222 T16942 T16995 themeOf IL-17,induction
R9223 T16944 T16996 themeOf IL-17,production
R9224 T16945 T16999 themeOf IL-17,induction
R9225 T16946 T17000 causeOf CD3,induced
R9226 T16947 T17001 themeOf IL-17,production
R9227 T16948 T17005 themeOf IL-17,production
R9228 T16949 T17008 themeOf IκB kinase-β,activated
R9229 T16952 T17013 themeOf IL-17,production
R9230 T16953 T17014 themeOf Akt,activation
R9231 T16954 T17015 themeOf Akt,phosphorylated
R9232 T16955 T17017 themeOf IL-17,induction
R9233 T16958 T17019 themeOf IL-17,induction
R9234 T16960 T17020 themeOf Akt,association
R9235 T16961 T17021 themeOf IL-17,inducing
R9236 T16961 T17022 themeOf IL-17,lacking
R9237 T16963 T17023 themeOf IL-17,upregulation
R9238 T16967 T16968 themeOf production,regulated
R9239 T16970 T16969 themeOf production,stimulate
R9240 T16972 T16974 themeOf increased,dependent
R9241 T16973 T16972 themeOf production,increased
R9242 T16973 T16974 themeOf production,dependent
R9243 T16978 T16979 themeOf production,augmented
R9244 T16981 T16980 themeOf production,stimulate
R9245 T16983 T16982 themeOf production,regulate
R9246 T16986 T16985 themeOf production,increased
R9247 T16988 T16987 themeOf production,augmented
R9248 T16991 T16990 themeOf production,affect
R9249 T16993 T16992 themeOf production,triggered
R9250 T16995 T16994 themeOf induction,increases
R9251 T16996 T16997 themeOf production,regulated
R9252 T16999 T16998 themeOf induction,involved
R9253 T17000 T17002 themeOf induced,hampered
R9254 T17001 T17002 themeOf production,hampered
R9255 T17001 T17000 themeOf production,induced
R9256 T17003 T17002 causeOf production,hampered
R9257 T17004 T17006 themeOf induced,downregulated
R9258 T17005 T17006 themeOf production,downregulated
R9259 T17005 T17004 themeOf production,induced
R9260 T17007 T17006 causeOf inhibitor,downregulated
R9261 T17011 T17012 themeOf binding,decreased
R9262 T17017 T17016 themeOf induction,involvement
R9263 T17019 T17018 themeOf induction,involved
R9264 T17025 T17024 themeOf binding,blocking
R9265 T17026 T16964 partOf promoter,IL-17
R9266 T17026 T17025 themeOf promoter,binding
R12057 T22058 T22066 themeOf IL-17,production
R12058 T22059 T22067 causeOf IL-15,in response to
R12059 T22060 T22067 causeOf MCP-1,in response to
R12060 T22061 T22067 causeOf CD28,in response to
R12061 T22062 T22068 themeOf IL-17,upregulation
R12062 T22064 T22070 themeOf IL-17,production
R12063 T22066 T22067 themeOf production,in response to
R12064 T22070 T22069 themeOf production,regulation
R3 T42 T74 themeOf IL-17,production
R29 T92 T91 themeOf overproduction,involved