PMC:1064873 / 5668-6009 JSONTXT

{"project":"LappsTest","denotations":[{"id":"T2231","span":{"begin":316,"end":319},"obj":"Protein"},{"id":"T2230","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T2229","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T2228","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T2227","span":{"begin":38,"end":42},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"2_test","denotations":[{"id":"15535835-12776222-4156880","span":{"begin":334,"end":336},"obj":"12776222"},{"id":"15535835-11259725-4156881","span":{"begin":337,"end":339},"obj":"11259725"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"biosemtest","denotations":[{"id":"T3112","span":{"begin":303,"end":319},"obj":"UP/O35735"},{"id":"T3108","span":{"begin":189,"end":198},"obj":"UMLS/C0037083"},{"id":"T3104","span":{"begin":303,"end":319},"obj":"UP/P63310"},{"id":"T3090","span":{"begin":303,"end":319},"obj":"UP/Q1WM28"},{"id":"T3074","span":{"begin":303,"end":319},"obj":"UP/O73915"},{"id":"T3073","span":{"begin":303,"end":319},"obj":"UP/Q9YGB9"},{"id":"T3070","span":{"begin":303,"end":319},"obj":"UP/P79154"},{"id":"T3069","span":{"begin":303,"end":319},"obj":"UP/P01579"},{"id":"T3066","span":{"begin":84,"end":87},"obj":"UMLS/C0454788"},{"id":"T3064","span":{"begin":303,"end":319},"obj":"UP/P42160"},{"id":"T3062","span":{"begin":233,"end":237},"obj":"UMLS/C0054942"},{"id":"T3055","span":{"begin":254,"end":261},"obj":"UMLS/C1963578"},{"id":"T3054","span":{"begin":303,"end":319},"obj":"UP/Q8MKF5"},{"id":"T3053","span":{"begin":202,"end":207},"obj":"UMLS/C0876919"},{"id":"T3048","span":{"begin":303,"end":319},"obj":"UP/P28333"},{"id":"T3034","span":{"begin":333,"end":338},"obj":"UMLS/C0384648"},{"id":"T2985","span":{"begin":242,"end":246},"obj":"UMLS/C0205170"},{"id":"T2984","span":{"begin":333,"end":338},"obj":"UMLS/C1623218"},{"id":"T2979","span":{"begin":303,"end":319},"obj":"UP/Q865X1"},{"id":"T2959","span":{"begin":224,"end":228},"obj":"UMLS/C1413235"},{"id":"T2922","span":{"begin":9,"end":19},"obj":"UMLS/C0549178"},{"id":"T2919","span":{"begin":333,"end":338},"obj":"UMLS/C1825592"},{"id":"T2908","span":{"begin":202,"end":207},"obj":"UMLS/C2348143"},{"id":"T2906","span":{"begin":303,"end":319},"obj":"UP/P01581"},{"id":"T2898","span":{"begin":84,"end":87},"obj":"UMLS/C0337876"},{"id":"T2830","span":{"begin":303,"end":319},"obj":"UP/Q9TV67"},{"id":"T2828","span":{"begin":303,"end":319},"obj":"UP/O77763"},{"id":"T2826","span":{"begin":303,"end":319},"obj":"UP/O57571"},{"id":"T2814","span":{"begin":156,"end":167},"obj":"UMLS/C1546634"},{"id":"T2790","span":{"begin":131,"end":142},"obj":"UMLS/C1550652"},{"id":"T2777","span":{"begin":76,"end":82},"obj":"UMLS/C1554106"},{"id":"T2766","span":{"begin":156,"end":167},"obj":"UMLS/C1550637"},{"id":"T2758","span":{"begin":303,"end":319},"obj":"UP/P49708"},{"id":"T2756","span":{"begin":303,"end":319},"obj":"UP/Q9QXX2"},{"id":"T2740","span":{"begin":303,"end":319},"obj":"UP/Q4ZH68"},{"id":"T2739","span":{"begin":69,"end":72},"obj":"UMLS/C0205388"},{"id":"T2736","span":{"begin":303,"end":319},"obj":"UP/A4PIZ9"},{"id":"T2702","span":{"begin":202,"end":207},"obj":"UMLS/C1704970"},{"id":"T2659","span":{"begin":303,"end":319},"obj":"UP/P42162"},{"id":"T3226","span":{"begin":202,"end":207},"obj":"UMLS/C0444504"},{"id":"T3209","span":{"begin":303,"end":319},"obj":"UP/Q62574"},{"id":"T3196","span":{"begin":131,"end":142},"obj":"UMLS/C0024432"},{"id":"T3187","span":{"begin":303,"end":319},"obj":"UP/P63311"},{"id":"T3183","span":{"begin":147,"end":155},"obj":"UMLS/C1550315"},{"id":"T3180","span":{"begin":254,"end":261},"obj":"UMLS/C0439180"},{"id":"T3178","span":{"begin":254,"end":261},"obj":"UMLS/C0680255"},{"id":"T3175","span":{"begin":303,"end":319},"obj":"UP/P07353"},{"id":"T3170","span":{"begin":303,"end":319},"obj":"UP/Q647G2"},{"id":"T3169","span":{"begin":303,"end":319},"obj":"UP/Q865Y4"},{"id":"T3166","span":{"begin":303,"end":319},"obj":"UP/Q5CCK0"},{"id":"T3164","span":{"begin":303,"end":319},"obj":"UP/P28341"},{"id":"T3161","span":{"begin":102,"end":112},"obj":"UMLS/C0443318"},{"id":"T3144","span":{"begin":76,"end":82},"obj":"UMLS/C0449788"},{"id":"T3132","span":{"begin":303,"end":319},"obj":"UP/Q25BC0"},{"id":"T3130","span":{"begin":303,"end":319},"obj":"UP/P01580"},{"id":"T3123","span":{"begin":48,"end":55},"obj":"UMLS/C0039194"},{"id":"T2652","span":{"begin":303,"end":319},"obj":"UP/P17773"},{"id":"T2643","span":{"begin":117,"end":127},"obj":"UMLS/C1879547"},{"id":"T2642","span":{"begin":33,"end":42},"obj":"UMLS/C1879547"},{"id":"T2635","span":{"begin":303,"end":319},"obj":"UP/O57608"},{"id":"T2627","span":{"begin":303,"end":319},"obj":"UP/O57603"},{"id":"T2896","span":{"begin":303,"end":319},"obj":"UP/Q7TSP4"},{"id":"T2895","span":{"begin":303,"end":319},"obj":"UP/Q8SPW9"},{"id":"T2892","span":{"begin":211,"end":223},"obj":"UMLS/C0699040"},{"id":"T2891","span":{"begin":176,"end":188},"obj":"UMLS/C0699040"},{"id":"T2878","span":{"begin":303,"end":319},"obj":"UP/P63309"},{"id":"T2875","span":{"begin":57,"end":61},"obj":"UMLS/C0587117"},{"id":"T2874","span":{"begin":76,"end":82},"obj":"UMLS/C0237753"},{"id":"T2873","span":{"begin":303,"end":319},"obj":"UP/P46402"},{"id":"T2858","span":{"begin":189,"end":198},"obj":"UMLS/C1710082"},{"id":"T2849","span":{"begin":156,"end":167},"obj":"UMLS/C0016030"},{"id":"T2619","span":{"begin":303,"end":319},"obj":"UP/Q2PE75"},{"id":"T2573","span":{"begin":303,"end":319},"obj":"UP/Q866Y6"},{"id":"T2571","span":{"begin":285,"end":294},"obj":"UMLS/C1524094"},{"id":"T2551","span":{"begin":303,"end":319},"obj":"UP/Q5I6S9"},{"id":"T2548","span":{"begin":303,"end":319},"obj":"UP/Q865W6"},{"id":"T2547","span":{"begin":333,"end":338},"obj":"UMLS/C1522571"},{"id":"T2544","span":{"begin":303,"end":319},"obj":"UP/P17803"},{"id":"T2528","span":{"begin":303,"end":319},"obj":"UMLS/C0021740"},{"id":"T2524","span":{"begin":303,"end":319},"obj":"UMLS/C0021745"},{"id":"T2523","span":{"begin":303,"end":319},"obj":"UP/Q9TTB0"},{"id":"T2510","span":{"begin":76,"end":82},"obj":"UMLS/C1709287"},{"id":"T2508","span":{"begin":224,"end":228},"obj":"UMLS/C0108800"},{"id":"T2486","span":{"begin":303,"end":319},"obj":"UP/P30123"},{"id":"T2485","span":{"begin":303,"end":319},"obj":"UP/O35497"},{"id":"T2484","span":{"begin":254,"end":261},"obj":"UMLS/C1283071"},{"id":"T2460","span":{"begin":303,"end":319},"obj":"UP/P42161"},{"id":"T2447","span":{"begin":202,"end":207},"obj":"UMLS/C2347634"},{"id":"T2445","span":{"begin":254,"end":261},"obj":"UMLS/C0391871"},{"id":"T2443","span":{"begin":285,"end":294},"obj":"UMLS/C0079189"},{"id":"T2617","span":{"begin":131,"end":142},"obj":"UMLS/C1546706"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"pmc-enju-pas","denotations":[{"id":"T4645","span":{"begin":339,"end":340},"obj":"-RRB-"},{"id":"T4644","span":{"begin":334,"end":339},"obj":"CD"},{"id":"T4643","span":{"begin":333,"end":334},"obj":"-LRB-"},{"id":"T4642","span":{"begin":327,"end":332},"obj":"NN"},{"id":"T4641","span":{"begin":323,"end":326},"obj":"CC"},{"id":"T4640","span":{"begin":320,"end":322},"obj":"NN"},{"id":"T4639","span":{"begin":319,"end":320},"obj":"-RRB-"},{"id":"T4638","span":{"begin":316,"end":319},"obj":"NN"},{"id":"T4637","span":{"begin":315,"end":316},"obj":"-LRB-"},{"id":"T4636","span":{"begin":309,"end":314},"obj":"NN"},{"id":"T4635","span":{"begin":298,"end":308},"obj":"NN"},{"id":"T4634","span":{"begin":295,"end":297},"obj":"IN"},{"id":"T4633","span":{"begin":290,"end":294},"obj":"JJ"},{"id":"T4632","span":{"begin":280,"end":289},"obj":"NN"},{"id":"T4631","span":{"begin":276,"end":279},"obj":"NN"},{"id":"T4630","span":{"begin":260,"end":275},"obj":"JJ"},{"id":"T4629","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T4628","span":{"begin":249,"end":256},"obj":"NN"},{"id":"T4627","span":{"begin":245,"end":248},"obj":"DT"},{"id":"T4626","span":{"begin":242,"end":244},"obj":"IN"},{"id":"T4625","span":{"begin":237,"end":241},"obj":"RB"},{"id":"T4624","span":{"begin":234,"end":236},"obj":"RB"},{"id":"T4623","span":{"begin":232,"end":233},"obj":"-COMMA-"},{"id":"T4622","span":{"begin":228,"end":232},"obj":"NN"},{"id":"T4621","span":{"begin":224,"end":227},"obj":"CC"},{"id":"T4620","span":{"begin":219,"end":223},"obj":"NN"},{"id":"T4619","span":{"begin":211,"end":218},"obj":"NN"},{"id":"T4618","span":{"begin":206,"end":210},"obj":"NN"},{"id":"T4617","span":{"begin":203,"end":205},"obj":"IN"},{"id":"T4616","span":{"begin":197,"end":202},"obj":"NN"},{"id":"T4615","span":{"begin":194,"end":196},"obj":"IN"},{"id":"T4614","span":{"begin":184,"end":193},"obj":"NN"},{"id":"T4613","span":{"begin":176,"end":183},"obj":"NN"},{"id":"T4612","span":{"begin":171,"end":175},"obj":"NN"},{"id":"T4611","span":{"begin":163,"end":170},"obj":"IN"},{"id":"T4610","span":{"begin":151,"end":162},"obj":"NN"},{"id":"T4609","span":{"begin":142,"end":150},"obj":"JJ"},{"id":"T4608","span":{"begin":138,"end":141},"obj":"CC"},{"id":"T4607","span":{"begin":126,"end":137},"obj":"NN"},{"id":"T4606","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T4605","span":{"begin":112,"end":122},"obj":"NN"},{"id":"T4604","span":{"begin":108,"end":111},"obj":"DT"},{"id":"T4603","span":{"begin":97,"end":107},"obj":"VB"},{"id":"T4602","span":{"begin":94,"end":96},"obj":"IN"},{"id":"T4601","span":{"begin":86,"end":93},"obj":"JJ"},{"id":"T4600","span":{"begin":83,"end":85},"obj":"VB"},{"id":"T4599","span":{"begin":79,"end":82},"obj":"MD"},{"id":"T4598","span":{"begin":77,"end":78},"obj":"-COMMA-"},{"id":"T4597","span":{"begin":71,"end":77},"obj":"NN"},{"id":"T4596","span":{"begin":68,"end":70},"obj":"IN"},{"id":"T4595","span":{"begin":64,"end":67},"obj":"JJ"},{"id":"T4594","span":{"begin":57,"end":63},"obj":"IN"},{"id":"T4593","span":{"begin":52,"end":56},"obj":"RB"},{"id":"T4592","span":{"begin":50,"end":51},"obj":"-COMMA-"},{"id":"T4591","span":{"begin":45,"end":50},"obj":"NN"},{"id":"T4590","span":{"begin":43,"end":44},"obj":"NN"},{"id":"T4589","span":{"begin":38,"end":42},"obj":"JJ"},{"id":"T4588","span":{"begin":28,"end":37},"obj":"VB"},{"id":"T4587","span":{"begin":25,"end":27},"obj":"IN"},{"id":"T4586","span":{"begin":15,"end":24},"obj":"NN"},{"id":"T4585","span":{"begin":4,"end":14},"obj":"VB"},{"id":"T4584","span":{"begin":0,"end":3},"obj":"DT"}],"relations":[{"id":"R1647","pred":"arg1Of","subj":"T4586","obj":"T4584"},{"id":"R1648","pred":"arg1Of","subj":"T4586","obj":"T4585"},{"id":"R1649","pred":"arg1Of","subj":"T4586","obj":"T4587"},{"id":"R1650","pred":"arg1Of","subj":"T4586","obj":"T4599"},{"id":"R1651","pred":"arg1Of","subj":"T4586","obj":"T4600"},{"id":"R1652","pred":"arg1Of","subj":"T4586","obj":"T4601"},{"id":"R1653","pred":"arg2Of","subj":"T4591","obj":"T4587"},{"id":"R1654","pred":"arg2Of","subj":"T4591","obj":"T4588"},{"id":"R1655","pred":"arg1Of","subj":"T4591","obj":"T4589"},{"id":"R1656","pred":"arg1Of","subj":"T4591","obj":"T4590"},{"id":"R1658","pred":"arg1Of","subj":"T4594","obj":"T4593"},{"id":"R1659","pred":"arg1Of","subj":"T4594","obj":"T4596"},{"id":"R1661","pred":"arg2Of","subj":"T4595","obj":"T4594"},{"id":"R1662","pred":"arg2Of","subj":"T4597","obj":"T4596"},{"id":"R1665","pred":"arg1Of","subj":"T4600","obj":"T4592"},{"id":"R1666","pred":"arg1Of","subj":"T4600","obj":"T4594"},{"id":"R1667","pred":"arg1Of","subj":"T4600","obj":"T4598"},{"id":"R1668","pred":"arg2Of","subj":"T4600","obj":"T4599"},{"id":"R1669","pred":"arg2Of","subj":"T4601","obj":"T4600"},{"id":"R1670","pred":"arg1Of","subj":"T4601","obj":"T4602"},{"id":"R1671","pred":"arg2Of","subj":"T4603","obj":"T4602"},{"id":"R1673","pred":"arg2Of","subj":"T4605","obj":"T4603"},{"id":"R1674","pred":"arg1Of","subj":"T4605","obj":"T4604"},{"id":"R1675","pred":"arg1Of","subj":"T4605","obj":"T4606"},{"id":"R1676","pred":"arg1Of","subj":"T4605","obj":"T4611"},{"id":"R1677","pred":"arg1Of","subj":"T4605","obj":"T4615"},{"id":"R1679","pred":"arg1Of","subj":"T4607","obj":"T4608"},{"id":"R1680","pred":"arg2Of","subj":"T4608","obj":"T4606"},{"id":"R1683","pred":"arg2Of","subj":"T4610","obj":"T4608"},{"id":"R1684","pred":"arg1Of","subj":"T4610","obj":"T4609"},{"id":"R1686","pred":"arg2Of","subj":"T4614","obj":"T4611"},{"id":"R1687","pred":"arg1Of","subj":"T4614","obj":"T4612"},{"id":"R1688","pred":"arg1Of","subj":"T4614","obj":"T4613"},{"id":"R1690","pred":"arg1Of","subj":"T4616","obj":"T4617"},{"id":"R1691","pred":"arg1Of","subj":"T4616","obj":"T4626"},{"id":"R1693","pred":"arg1Of","subj":"T4620","obj":"T4618"},{"id":"R1694","pred":"arg1Of","subj":"T4620","obj":"T4619"},{"id":"R1695","pred":"arg1Of","subj":"T4620","obj":"T4621"},{"id":"R1696","pred":"arg2Of","subj":"T4621","obj":"T4617"},{"id":"R1697","pred":"arg2Of","subj":"T4622","obj":"T4621"},{"id":"R1701","pred":"arg2Of","subj":"T4626","obj":"T4615"},{"id":"R1702","pred":"arg1Of","subj":"T4626","obj":"T4623"},{"id":"R1703","pred":"arg1Of","subj":"T4626","obj":"T4624"},{"id":"R1704","pred":"arg1Of","subj":"T4626","obj":"T4625"},{"id":"R1706","pred":"arg2Of","subj":"T4628","obj":"T4626"},{"id":"R1707","pred":"arg1Of","subj":"T4628","obj":"T4627"},{"id":"R1708","pred":"arg1Of","subj":"T4628","obj":"T4629"},{"id":"R1712","pred":"arg2Of","subj":"T4632","obj":"T4629"},{"id":"R1713","pred":"arg1Of","subj":"T4632","obj":"T4630"},{"id":"R1714","pred":"arg1Of","subj":"T4632","obj":"T4631"},{"id":"R1715","pred":"arg1Of","subj":"T4632","obj":"T4634"},{"id":"R1717","pred":"arg1Of","subj":"T4634","obj":"T4633"},{"id":"R1720","pred":"arg1Of","subj":"T4636","obj":"T4635"},{"id":"R1721","pred":"arg1Of","subj":"T4636","obj":"T4637"},{"id":"R1722","pred":"arg2Of","subj":"T4638","obj":"T4637"},{"id":"R1723","pred":"arg3Of","subj":"T4639","obj":"T4637"},{"id":"R1724","pred":"arg1Of","subj":"T4640","obj":"T4636"},{"id":"R1725","pred":"arg1Of","subj":"T4640","obj":"T4641"},{"id":"R1726","pred":"arg2Of","subj":"T4641","obj":"T4634"},{"id":"R1727","pred":"arg2Of","subj":"T4642","obj":"T4641"},{"id":"R1729","pred":"arg1Of","subj":"T4642","obj":"T4643"},{"id":"R1730","pred":"arg2Of","subj":"T4644","obj":"T4643"},{"id":"R1731","pred":"arg3Of","subj":"T4645","obj":"T4643"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T3461","span":{"begin":327,"end":332},"obj":"Antecedent"},{"id":"T3460","span":{"begin":298,"end":314},"obj":"Antecedent"},{"id":"T3459","span":{"begin":260,"end":289},"obj":"Anaphor"}],"relations":[{"id":"R944","pred":"boundBy","subj":"T3459","obj":"T3460"},{"id":"R945","pred":"boundBy","subj":"T3459","obj":"T3461"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T3519","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T3518","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T3517","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T3516","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T3515","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T3514","span":{"begin":38,"end":41},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3859","span":{"begin":327,"end":332},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T3857","span":{"begin":309,"end":319},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T3844","span":{"begin":38,"end":41},"obj":"http://www.uniprot.org/uniprot/P01730"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"GO-BP","denotations":[{"id":"T3301","span":{"begin":112,"end":137},"obj":"http://purl.obolibrary.org/obo/GO_0042116"},{"id":"T3283","span":{"begin":184,"end":193},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"GO-CC","denotations":[{"id":"T3596","span":{"begin":206,"end":218},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T3595","span":{"begin":171,"end":183},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T3585","span":{"begin":206,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3584","span":{"begin":171,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"GO-MF","denotations":[{"id":"T3577","span":{"begin":327,"end":332},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T3576","span":{"begin":298,"end":314},"obj":"http://purl.obolibrary.org/obo/GO_0005133"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"sentences","denotations":[{"id":"T3254","span":{"begin":0,"end":341},"obj":"Sentence"},{"id":"T31","span":{"begin":0,"end":341},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"simple1","denotations":[{"id":"T3922","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T3921","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T3920","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T3919","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T3918","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T3917","span":{"begin":38,"end":41},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T6469","span":{"begin":249,"end":256},"obj":"Localization"},{"id":"T6432","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T6431","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T6430","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T6429","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T6428","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T6427","span":{"begin":38,"end":41},"obj":"Protein"}],"relations":[{"id":"R3160","pred":"themeOf","subj":"T6430","obj":"T6469"},{"id":"R3166","pred":"themeOf","subj":"T6431","obj":"T6469"},{"id":"R3168","pred":"themeOf","subj":"T6432","obj":"T6469"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T4870","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T4869","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T4868","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T4867","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T4866","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T4865","span":{"begin":38,"end":41},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"DLUT931","denotations":[{"id":"T5882","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T5881","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T5880","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T5879","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T5878","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T5877","span":{"begin":38,"end":41},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T6247","span":{"begin":276,"end":297},"obj":"Protein"},{"id":"T6185","span":{"begin":171,"end":183},"obj":"Entity"},{"id":"T6180","span":{"begin":206,"end":223},"obj":"Protein"},{"id":"T6243","span":{"begin":276,"end":308},"obj":"Protein"},{"id":"T6218","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T6206","span":{"begin":142,"end":162},"obj":"Entity"},{"id":"T6278","span":{"begin":126,"end":137},"obj":"Entity"},{"id":"T6291","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T6338","span":{"begin":206,"end":218},"obj":"Entity"},{"id":"T6325","span":{"begin":316,"end":319},"obj":"Protein"},{"id":"T6300","span":{"begin":28,"end":50},"obj":"Entity"},{"id":"T6371","span":{"begin":206,"end":224},"obj":"Localization"}],"relations":[{"id":"R3103","pred":"themeOf","subj":"T6180","obj":"T6371"},{"id":"R3136","pred":"locationOf","subj":"T6338","obj":"T6371"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T5603","span":{"begin":86,"end":93},"obj":"JJ"},{"id":"T5602","span":{"begin":83,"end":85},"obj":"VB"},{"id":"T5601","span":{"begin":79,"end":82},"obj":"MD"},{"id":"T5600","span":{"begin":77,"end":78},"obj":","},{"id":"T5599","span":{"begin":71,"end":77},"obj":"NN"},{"id":"T5598","span":{"begin":68,"end":70},"obj":"IN"},{"id":"T5597","span":{"begin":64,"end":67},"obj":"JJ"},{"id":"T5596","span":{"begin":57,"end":63},"obj":"IN"},{"id":"T5595","span":{"begin":52,"end":56},"obj":"RB"},{"id":"T5594","span":{"begin":50,"end":51},"obj":","},{"id":"T5593","span":{"begin":45,"end":50},"obj":"NNS"},{"id":"T5592","span":{"begin":43,"end":44},"obj":"NNP"},{"id":"T5591","span":{"begin":41,"end":42},"obj":"CD"},{"id":"T5590","span":{"begin":38,"end":41},"obj":"NNP"},{"id":"T5589","span":{"begin":28,"end":37},"obj":"VBN"},{"id":"T5588","span":{"begin":25,"end":27},"obj":"IN"},{"id":"T5587","span":{"begin":15,"end":24},"obj":"NN"},{"id":"T5586","span":{"begin":4,"end":14},"obj":"VBG"},{"id":"T5585","span":{"begin":0,"end":3},"obj":"DT"},{"id":"T5632","span":{"begin":260,"end":275},"obj":"JJ"},{"id":"T5631","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T5630","span":{"begin":249,"end":256},"obj":"NN"},{"id":"T5629","span":{"begin":245,"end":248},"obj":"DT"},{"id":"T5628","span":{"begin":242,"end":244},"obj":"IN"},{"id":"T5627","span":{"begin":237,"end":241},"obj":"RB"},{"id":"T5626","span":{"begin":234,"end":236},"obj":"RB"},{"id":"T5625","span":{"begin":232,"end":233},"obj":","},{"id":"T5624","span":{"begin":228,"end":232},"obj":"NNP"},{"id":"T5623","span":{"begin":224,"end":227},"obj":"CC"},{"id":"T5622","span":{"begin":219,"end":223},"obj":"NNP"},{"id":"T5621","span":{"begin":211,"end":218},"obj":"NN"},{"id":"T5620","span":{"begin":206,"end":210},"obj":"NN"},{"id":"T5619","span":{"begin":203,"end":205},"obj":"IN"},{"id":"T5618","span":{"begin":197,"end":202},"obj":"NNS"},{"id":"T5617","span":{"begin":194,"end":196},"obj":"IN"},{"id":"T5616","span":{"begin":184,"end":193},"obj":"VBG"},{"id":"T5615","span":{"begin":176,"end":183},"obj":"NN"},{"id":"T5614","span":{"begin":171,"end":175},"obj":"NN"},{"id":"T5613","span":{"begin":163,"end":170},"obj":"IN"},{"id":"T5612","span":{"begin":151,"end":162},"obj":"NNS"},{"id":"T5611","span":{"begin":142,"end":150},"obj":"JJ"},{"id":"T5610","span":{"begin":138,"end":141},"obj":"CC"},{"id":"T5609","span":{"begin":126,"end":137},"obj":"NNS"},{"id":"T5608","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T5607","span":{"begin":112,"end":122},"obj":"NN"},{"id":"T5606","span":{"begin":108,"end":111},"obj":"DT"},{"id":"T5605","span":{"begin":97,"end":107},"obj":"VBG"},{"id":"T5604","span":{"begin":94,"end":96},"obj":"IN"},{"id":"T5649","span":{"begin":340,"end":341},"obj":"."},{"id":"T5648","span":{"begin":339,"end":340},"obj":"NNP"},{"id":"T5647","span":{"begin":334,"end":339},"obj":"CD"},{"id":"T5646","span":{"begin":333,"end":334},"obj":"NNP"},{"id":"T5645","span":{"begin":327,"end":332},"obj":"NNP"},{"id":"T5644","span":{"begin":323,"end":326},"obj":"CC"},{"id":"T5643","span":{"begin":321,"end":322},"obj":"NN"},{"id":"T5642","span":{"begin":320,"end":321},"obj":":"},{"id":"T5641","span":{"begin":319,"end":320},"obj":"-RRB-"},{"id":"T5640","span":{"begin":316,"end":319},"obj":"NNP"},{"id":"T5639","span":{"begin":315,"end":316},"obj":"-LRB-"},{"id":"T5638","span":{"begin":309,"end":314},"obj":"NN"},{"id":"T5637","span":{"begin":298,"end":308},"obj":"NN"},{"id":"T5636","span":{"begin":295,"end":297},"obj":"IN"},{"id":"T5635","span":{"begin":290,"end":294},"obj":"JJ"},{"id":"T5634","span":{"begin":280,"end":289},"obj":"NNS"},{"id":"T5633","span":{"begin":276,"end":279},"obj":"JJ"}],"relations":[{"id":"R2634","pred":"prep","subj":"T5604","obj":"T5602"},{"id":"R2636","pred":"pcomp","subj":"T5605","obj":"T5604"},{"id":"R2641","pred":"det","subj":"T5606","obj":"T5607"},{"id":"R2645","pred":"dobj","subj":"T5607","obj":"T5605"},{"id":"R2648","pred":"prep","subj":"T5608","obj":"T5607"},{"id":"R2651","pred":"pobj","subj":"T5609","obj":"T5608"},{"id":"R2655","pred":"cc","subj":"T5610","obj":"T5609"},{"id":"R2656","pred":"det","subj":"T5585","obj":"T5587"},{"id":"R2657","pred":"amod","subj":"T5586","obj":"T5587"},{"id":"R2658","pred":"nsubj","subj":"T5587","obj":"T5602"},{"id":"R2659","pred":"amod","subj":"T5611","obj":"T5612"},{"id":"R2660","pred":"prep","subj":"T5588","obj":"T5587"},{"id":"R2661","pred":"amod","subj":"T5589","obj":"T5593"},{"id":"R2662","pred":"conj","subj":"T5612","obj":"T5609"},{"id":"R2663","pred":"compound","subj":"T5590","obj":"T5593"},{"id":"R2664","pred":"nummod","subj":"T5591","obj":"T5593"},{"id":"R2665","pred":"prep","subj":"T5613","obj":"T5605"},{"id":"R2666","pred":"compound","subj":"T5592","obj":"T5593"},{"id":"R2667","pred":"pobj","subj":"T5593","obj":"T5588"},{"id":"R2668","pred":"punct","subj":"T5594","obj":"T5587"},{"id":"R2669","pred":"compound","subj":"T5614","obj":"T5615"},{"id":"R2670","pred":"advmod","subj":"T5595","obj":"T5597"},{"id":"R2671","pred":"advmod","subj":"T5596","obj":"T5597"},{"id":"R2672","pred":"advcl","subj":"T5597","obj":"T5602"},{"id":"R2673","pred":"pobj","subj":"T5615","obj":"T5613"},{"id":"R2674","pred":"prep","subj":"T5598","obj":"T5597"},{"id":"R2675","pred":"pobj","subj":"T5599","obj":"T5598"},{"id":"R2676","pred":"punct","subj":"T5600","obj":"T5602"},{"id":"R2677","pred":"conj","subj":"T5616","obj":"T5605"},{"id":"R2678","pred":"aux","subj":"T5601","obj":"T5602"},{"id":"R2679","pred":"ROOT","subj":"T5602","obj":"T5602"},{"id":"R2680","pred":"acomp","subj":"T5603","obj":"T5602"},{"id":"R2681","pred":"prep","subj":"T5617","obj":"T5616"},{"id":"R2682","pred":"amod","subj":"T5633","obj":"T5634"},{"id":"R2683","pred":"pobj","subj":"T5618","obj":"T5617"},{"id":"R2684","pred":"pobj","subj":"T5634","obj":"T5631"},{"id":"R2685","pred":"amod","subj":"T5635","obj":"T5636"},{"id":"R2686","pred":"prep","subj":"T5636","obj":"T5634"},{"id":"R2687","pred":"prep","subj":"T5619","obj":"T5618"},{"id":"R2688","pred":"compound","subj":"T5637","obj":"T5638"},{"id":"R2689","pred":"pobj","subj":"T5638","obj":"T5636"},{"id":"R2690","pred":"punct","subj":"T5639","obj":"T5640"},{"id":"R2691","pred":"compound","subj":"T5620","obj":"T5621"},{"id":"R2692","pred":"appos","subj":"T5640","obj":"T5638"},{"id":"R2693","pred":"punct","subj":"T5641","obj":"T5640"},{"id":"R2694","pred":"punct","subj":"T5642","obj":"T5638"},{"id":"R2695","pred":"compound","subj":"T5621","obj":"T5622"},{"id":"R2696","pred":"conj","subj":"T5643","obj":"T5638"},{"id":"R2697","pred":"cc","subj":"T5644","obj":"T5643"},{"id":"R2698","pred":"compound","subj":"T5645","obj":"T5646"},{"id":"R2699","pred":"pobj","subj":"T5622","obj":"T5619"},{"id":"R2700","pred":"appos","subj":"T5646","obj":"T5630"},{"id":"R2701","pred":"compound","subj":"T5647","obj":"T5648"},{"id":"R2702","pred":"appos","subj":"T5648","obj":"T5646"},{"id":"R2703","pred":"cc","subj":"T5623","obj":"T5622"},{"id":"R2704","pred":"punct","subj":"T5649","obj":"T5602"},{"id":"R2705","pred":"conj","subj":"T5624","obj":"T5622"},{"id":"R2707","pred":"punct","subj":"T5625","obj":"T5616"},{"id":"R2711","pred":"advmod","subj":"T5626","obj":"T5628"},{"id":"R2715","pred":"advmod","subj":"T5627","obj":"T5628"},{"id":"R2718","pred":"cc","subj":"T5628","obj":"T5630"},{"id":"R2721","pred":"det","subj":"T5629","obj":"T5630"},{"id":"R2725","pred":"advcl","subj":"T5630","obj":"T5602"},{"id":"R2729","pred":"prep","subj":"T5631","obj":"T5630"},{"id":"R2735","pred":"amod","subj":"T5632","obj":"T5634"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T3795","span":{"begin":249,"end":256},"obj":"Localization"},{"id":"T3794","span":{"begin":249,"end":256},"obj":"Localization"},{"id":"T3793","span":{"begin":316,"end":319},"obj":"Protein"},{"id":"T3792","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T3791","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T3790","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T3789","span":{"begin":38,"end":41},"obj":"Protein"}],"relations":[{"id":"R996","pred":"themeOf","subj":"T3792","obj":"T3794"},{"id":"R997","pred":"themeOf","subj":"T3793","obj":"T3795"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"test3","denotations":[{"id":"T2402","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T2401","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T2400","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T2399","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T2398","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T2397","span":{"begin":38,"end":41},"obj":"Protein"},{"id":"T2314","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T2313","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T2312","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T2311","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T2310","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T2309","span":{"begin":38,"end":41},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}

{"project":"testone","denotations":[{"id":"T2128","span":{"begin":327,"end":332},"obj":"Protein"},{"id":"T2127","span":{"begin":315,"end":322},"obj":"Protein"},{"id":"T2126","span":{"begin":298,"end":314},"obj":"Protein"},{"id":"T2125","span":{"begin":228,"end":232},"obj":"Protein"},{"id":"T2124","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T2123","span":{"begin":38,"end":41},"obj":"Protein"}],"text":"The continuing emergence of activated CD4+ T cells, even though few in number, may be crucial in sustaining the activation of macrophages and synovial fibroblasts through cell surface signaling by means of cell surface CD69 and CD11, as well as the release of proinflammatory Th1 cytokines such as interferon gamma (IFN)-γ and IL-17 [21,22]."}