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In addition, the anti-inflammatory action of IL-10 appears to be modulated at the level of signal transduction during chronic inflammation. IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1 and immune complexes [13,14]. Cell surface expression of IL-10R1 is decreased in synovial fluid dendritic cells d"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T3503","span":{"begin":347,"end":354},"obj":"Protein"},{"id":"T3502","span":{"begin":285,"end":289},"obj":"Protein"},{"id":"T3501","span":{"begin":275,"end":280},"obj":"Protein"},{"id":"T3500","span":{"begin":173,"end":178},"obj":"Protein"},{"id":"T3499","span":{"begin":78,"end":83},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":" of proinflammatory events [12]. In addition, the anti-inflammatory action of IL-10 appears to be modulated at the level of signal transduction during chronic inflammation. IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1 and immune complexes [13,14]. Cell surface expression of IL-10R1 is decreased in synovial fluid dendritic cells d"}

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{"project":"UBERON-AE","denotations":[{"id":"T2428","span":{"begin":371,"end":385},"obj":"http://purl.obolibrary.org/obo/UBERON_0001090"}],"text":" of proinflammatory events [12]. In addition, the anti-inflammatory action of IL-10 appears to be modulated at the level of signal transduction during chronic inflammation. IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1 and immune complexes [13,14]. Cell surface expression of IL-10R1 is decreased in synovial fluid dendritic cells d"}

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