PMC:1064873 / 23422-34571 JSON TXT

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LappsTest

Id	Subject	Object	Predicate	Lexical cue
T22250	11090-11093	Protein	denotes	Th1
T22249	10956-10963	Protein	denotes	PB CD4+
T22248	10936-10941	Protein	denotes	SOCS3
T22247	10908-10913	Protein	denotes	SOCS1
T22246	10862-10865	Protein	denotes	IgE
T22245	10818-10823	Protein	denotes	SOCS3
T22244	10791-10808	Protein	denotes	SOCS3 transcripts
T22243	10631-10642	Protein	denotes	IL-12–STAT4
T22242	10612-10622	Protein	denotes	IL-4–STAT6
T22241	10549-10552	Protein	denotes	Th2
T22240	10532-10535	Protein	denotes	Th1
T22239	10493-10498	Protein	denotes	SOCS3
T22238	10483-10488	Protein	denotes	SOCS1
T22237	10453-10458	Protein	denotes	SOCS1
T22236	10420-10425	Protein	denotes	STAT6
T22235	10407-10411	Protein	denotes	IL-4
T22234	10369-10374	Protein	denotes	SOCS3
T22233	10336-10341	Protein	denotes	STAT4
T22232	10322-10327	Protein	denotes	IL-12
T22231	10291-10301	Protein	denotes	SOCS3 mRNA
T22213	9423-9428	Protein	denotes	SOCS3
T22212	9370-9374	Protein	denotes	IL-6
T22211	9334-9339	Protein	denotes	SOCS3
T22210	9287-9292	Protein	denotes	SOCS3
T22209	9258-9262	Protein	denotes	IL-6
T22208	9237-9242	Protein	denotes	STAT3
T22207	9184-9189	Protein	denotes	SOCS1
T22206	9158-9163	Protein	denotes	SOCS3
T22205	9121-9126	Protein	denotes	SOCS3
T22204	9081-9086	Protein	denotes	IL-10
T22203	9055-9059	Protein	denotes	IL-6
T22202	9022-9027	Protein	denotes	SOCS3
T22201	9002-9007	Protein	denotes	SOCS1
T22200	8993-8998	Protein	denotes	SOCS3
T22199	8889-8894	Protein	denotes	IL-10
T22198	8880-8884	Protein	denotes	IL-6
T22197	8830-8835	Protein	denotes	SOCS3
T22196	8820-8825	Protein	denotes	SOCS1
T22195	8808-8813	Protein	denotes	gp130
T22194	8745-8799	Protein	denotes	Src homology phosphatase-2-binding domain of receptors
T22193	8723-8726	Protein	denotes	JAK
T22192	8694-8699	Protein	denotes	SOCS3
T22191	8629-8634	Protein	denotes	SOCS1
T22190	8615-8619	Protein	denotes	CD4+
T22189	8587-8592	Protein	denotes	SOCS3
T22188	8560-8565	Protein	denotes	SOCS1
T22187	8491-8495	Protein	denotes	CD4+
T22186	8451-8471	Protein	denotes	SOCS family proteins
T22185	8414-8430	Protein	denotes	JAK–STAT pathway
T22184	8344-8349	Protein	denotes	STAT3
T22183	8329-8334	Protein	denotes	gp130
T22182	8228-8232	Protein	denotes	CD4+
T22181	8181-8195	Protein	denotes	gp130F759/F759
T22180	8093-8123	Protein	denotes	IL-6 family cytokine receptor)
T22179	8038-8085	Protein	denotes	gp130 (the transmembrane glycoprotein β subunit
T22178	7995-8034	Protein	denotes	Src homology phosphatase-2 binding site
T22177	7961-7975	Protein	denotes	gp130F759/F759
T22176	7884-7887	Protein	denotes	Th1
T22175	7865-7870	Protein	denotes	STAT3
T22174	7719-7724	Protein	denotes	STAT3
T22173	7681-7685	Protein	denotes	IL-6
T22172	7593-7598	Protein	denotes	STAT3
T22171	7553-7557	Protein	denotes	IL-6
T22170	7514-7519	Protein	denotes	STAT3
T22169	7416-7453	Protein	denotes	Fc gamma receptor type I and type III
T22168	7269-7292	Protein	denotes	STAT3-activating factor
T22167	7251-7255	Protein	denotes	IL-6
T22166	7158-7163	Protein	denotes	STAT3
T22165	7087-7092	Protein	denotes	STAT3
T22164	6928-6933	Protein	denotes	IL-10
T22163	6874-6879	Protein	denotes	IL-10
T22162	6832-6845	Protein	denotes	SOCS1 protein
T22161	6815-6819	Protein	denotes	IFN-
T22160	6794-6799	Protein	denotes	STAT3
T22159	6761-6766	Protein	denotes	IL-10
T22158	6650-6655	Protein	denotes	IL-10
T22157	6592-6596	Protein	denotes	CD4+
T22156	6564-6568	Protein	denotes	IFN-
T22155	6528-6532	Protein	denotes	IL-6
T22154	6477-6481	Protein	denotes	IL-1
T22153	6431-6435	Protein	denotes	CD4+
T22152	6396-6415	Protein	denotes	IL-10-mediated IFN-
T22151	6178-6182	Protein	denotes	IL-6
T22150	6104-6109	Protein	denotes	IL-10
T22149	6088-6092	Protein	denotes	CD4+
T22148	6020-6025	Protein	denotes	STAT3
T22147	6006-6011	Protein	denotes	IL-10
T22146	5938-5942	Protein	denotes	CD4+
T22145	5853-5860	Protein	denotes	RA CD4+
T22144	5838-5843	Protein	denotes	IL-10
T22143	5773-5778	Protein	denotes	IL-10
T22142	5747-5751	Protein	denotes	CD4+
T22141	5697-5702	Protein	denotes	STAT3
T22140	5657-5661	Protein	denotes	IL-6
T22139	5563-5570	Protein	denotes	RA CD4+
T22138	5537-5542	Protein	denotes	IL-10
T22137	5498-5503	Protein	denotes	STAT3
T22136	5446-5450	Protein	denotes	IL-6
T22135	5399-5403	Protein	denotes	CD4+
T22134	5368-5373	Protein	denotes	IL-10
T22133	5272-5295	Protein	denotes	STAT3-activating factor
T22132	5253-5257	Protein	denotes	IL-6
T22131	5055-5059	Protein	denotes	IL-6
T22130	4975-5007	Protein	denotes	oncostatin M) and growth factors
T22129	4930-4934	Protein	denotes	IL-6
T22128	4899-4910	Protein	denotes	IL-6 family
T22127	4841-4846	Protein	denotes	STAT3
T22126	4807-4814	Protein	denotes	ST CD4+
T22125	4705-4710	Protein	denotes	STAT3
T22124	4687-4692	Protein	denotes	STAT3
T22123	4448-4455	Protein	denotes	IL-10R1
T22122	4417-4422	Protein	denotes	STAT3
T22121	4362-4367	Protein	denotes	IL-10
T22120	4343-4350	Protein	denotes	RA CD4+
T22119	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T22118	4234-4238	Protein	denotes	IL-1
T22117	4227-4231	Protein	denotes	TNF-
T22116	4109-4114	Protein	denotes	IL-10
T22115	3980-4001	Protein	denotes	IgG Fc gamma receptor
T22114	3919-3933	Protein	denotes	protein kinase
T22113	3855-3859	Protein	denotes	Jak1
T22112	3841-3846	Protein	denotes	IL-10
T22111	3818-3825	Protein	denotes	IL-10R1
T22110	3707-3712	Protein	denotes	IL-10
T22109	3625-3630	Protein	denotes	STAT3
T22108	3610-3615	Protein	denotes	IL-10
T22107	3558-3562	Protein	denotes	IL-6
T22106	3548-3553	Protein	denotes	IL-10
T22105	3509-3519	Protein	denotes	Jak1–STAT3
T22104	3490-3494	Protein	denotes	IL-1
T22103	3480-3484	Protein	denotes	TNF-
T22102	3448-3458	Protein	denotes	p38 kinase
T22101	3404-3443	Protein	denotes	extracellular stimulus-regulated kinase
T22100	3177-3182	Protein	denotes	IL-10
T22099	2968-2972	Protein	denotes	IL-2
T22098	2958-2962	Protein	denotes	IFN-
T22097	2921-2925	Protein	denotes	CD28
T22096	2866-2873	Protein	denotes	PB CD4+
T22095	2754-2758	Protein	denotes	CD28
T22094	2664-2669	Protein	denotes	IL-10
T22093	2615-2636	Protein	denotes	MHC class II antigens
T22092	2595-2609	Protein	denotes	CD86 molecules
T22091	2586-2590	Protein	denotes	CD80
T22090	2286-2317	Protein	denotes	CD4+ T-cell cytokine production
T22089	2240-2245	Protein	denotes	SOCS1
T22088	2214-2219	Protein	denotes	STAT3
T22087	2166-2171	Protein	denotes	STAT3
T22086	1982-1986	Protein	denotes	CD4+
T22085	1939-1943	Protein	denotes	CD4+
T22084	1895-1912	Protein	denotes	SOCS3 transcripts
T22083	1861-1866	Protein	denotes	SOCS1
T22082	1820-1827	Protein	denotes	RA CD4+
T22081	1782-1787	Protein	denotes	IL-10
T22080	1751-1755	Protein	denotes	IL-6
T22079	1723-1727	Protein	denotes	CD4+
T22078	1691-1696	Protein	denotes	STAT1
T22077	1677-1682	Protein	denotes	STAT3
T22076	1647-1651	Protein	denotes	IL-6
T22075	1634-1639	Protein	denotes	IL-10
T22074	1579-1584	Protein	denotes	STAT3
T22073	1559-1563	Protein	denotes	CD4+
T22072	1520-1527	Protein	denotes	RA CD4+
T22071	1497-1502	Protein	denotes	STAT3
T22070	1455-1460	Protein	denotes	IL-10
T22069	1437-1442	Protein	denotes	STAT3
T22068	1401-1408	Protein	denotes	IL-10R1
T22067	1368-1372	Protein	denotes	CD4+
T22066	1273-1278	Protein	denotes	IL-10
T22065	1208-1215	Protein	denotes	PB CD4+
T22064	1079-1108	Protein	denotes	phosphatidylinositol 3-kinase
T22063	1046-1059	Protein	denotes	CD28 molecule
T22062	995-1000	Protein	denotes	IL-10
T22061	852-857	Protein	denotes	IL-10
T22060	791-818	Protein	denotes	T-cell-associated antigen 4
T22059	661-665	Protein	denotes	CD28
T22058	513-534	Protein	denotes	MHC class II antigens
T22057	493-497	Protein	denotes	CD86
T22056	484-488	Protein	denotes	CD80
T22055	465-469	Protein	denotes	CD28
T22054	414-418	Protein	denotes	CD28
T22053	383-399	Protein	denotes	antigen receptor
T22052	333-337	Protein	denotes	CD4+
T22051	237-250	Protein	denotes	Th1 cytokines
T22050	101-105	Protein	denotes	CD4+
T22049	40-43	Protein	denotes	Th1
T22048	11-15	Protein	denotes	CD4+
T22230	10281-10286	Protein	denotes	SOCS1
T22229	10240-10243	Protein	denotes	Th1
T22228	10168-10173	Protein	denotes	SOCS1
T22227	10105-10110	Protein	denotes	IL-10
T22226	10023-10027	Protein	denotes	CD4+
T22225	9984-9988	Protein	denotes	CD4+
T22224	9930-9935	Protein	denotes	SOCS1
T22223	9896-9900	Protein	denotes	IL-6
T22222	9858-9863	Protein	denotes	STAT3
T22221	9807-9812	Protein	denotes	SOCS3
T22220	9775-9780	Protein	denotes	STAT3
T22219	9760-9765	Protein	denotes	IL-10
T22218	9747-9752	Protein	denotes	IL-10
T22217	9662-9669	Protein	denotes	RA CD4+
T22216	9642-9647	Protein	denotes	SOCS1
T22215	9601-9606	Protein	denotes	IL-10
T22214	9565-9570	Protein	denotes	SOCS1

2_test

Id	Subject	Object	Predicate	Lexical cue
15535835-11259725-4156903	86-88	11259725	denotes	22
15535835-8624620-4156904	633-635	8624620	denotes	18
15535835-8546719-4156904	633-635	8546719	denotes	18
15535835-10529123-4156904	633-635	10529123	denotes	18
15535835-14614165-4156905	847-849	14614165	denotes	23
15535835-11244051-4156906	991-992	11244051	denotes	1
15535835-10898505-4156907	1167-1169	10898505	denotes	24
15535835-11244051-4156908	2409-2410	11244051	denotes	1
15535835-8717520-4156909	2638-2640	8717520	denotes	10
15535835-8624620-4156910	2641-2643	8624620	denotes	18
15535835-8546719-4156910	2641-2643	8546719	denotes	18
15535835-10529123-4156910	2641-2643	10529123	denotes	18
15535835-11412299-4156911	2785-2787	11412299	denotes	33
15535835-8717520-4156912	3161-3163	8717520	denotes	10
15535835-8163935-4156913	3286-3288	8163935	denotes	12
15535835-11046056-4156914	3587-3589	11046056	denotes	13
15535835-12782719-4156915	4003-4005	12782719	denotes	14
15535835-10553089-4156916	4294-4296	10553089	denotes	15
15535835-12039028-4156917	5031-5032	12039028	denotes	4
15535835-9182920-4156918	5219-5221	9182920	denotes	27
15535835-7612044-4156919	5933-5935	7612044	denotes	34
15535835-9182920-4156920	6237-6239	9182920	denotes	27
15535835-7612044-4156921	6728-6730	7612044	denotes	34
15535835-9751101-4156922	6731-6733	9751101	denotes	35
15535835-12538698-4156923	6891-6893	12538698	denotes	32
15535835-8717520-4156924	7082-7084	8717520	denotes	10
15535835-7500028-4156925	7246-7248	7500028	denotes	36
15535835-7869026-4156926	7469-7471	7869026	denotes	31
15535835-11748261-4156927	7698-7700	11748261	denotes	37
15535835-12444174-4156928	7816-7818	12444174	denotes	38
15535835-12370259-4156929	8169-8171	12370259	denotes	39
15535835-11527983-4156930	8473-8474	11527983	denotes	7
15535835-14644140-4156931	8815-8817	14644140	denotes	40
15535835-11527983-4156932	8956-8957	11527983	denotes	7
15535835-12754507-4156933	9264-9265	12754507	denotes	8
15535835-12754506-4156934	9266-9268	12754506	denotes	41
15535835-12754505-4156935	9409-9411	12754505	denotes	42
15535835-12754506-4156936	9543-9545	12754506	denotes	41
15535835-10452970-4156937	9627-9629	10452970	denotes	43
15535835-12538698-4156938	10175-10177	12538698	denotes	32
15535835-11907070-4156939	10317-10319	11907070	denotes	44
15535835-12847520-4156940	10896-10898	12847520	denotes	45
15535835-7594511-4156941	11142-11144	7594511	denotes	46
15535835-9822289-4156941	11142-11144	9822289	denotes	46
15535835-10728756-4156941	11142-11144	10728756	denotes	46
15535835-11178127-4156941	11142-11144	11178127	denotes	46

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T26340	11142-11147	CD	denotes	46-49
T26341	11147-11148	-RRB-	denotes	]
T26339	11141-11142	-LRB-	denotes	[
T26338	11128-11140	VB	denotes	demonstrated
T26337	11123-11127	VB	denotes	been
T26336	11112-11122	RB	denotes	previously
T26335	11108-11111	VB	denotes	has
T26334	11105-11107	IN	denotes	as
T26333	11103-11104	-COMMA-	denotes	,
T26332	11094-11103	NN	denotes	phenotype
T26331	11090-11093	NN	denotes	Th1
T26330	11088-11089	DT	denotes	a
T26329	11080-11087	IN	denotes	towards
T26328	11075-11079	NN	denotes	bias
T26327	11066-11074	JJ	denotes	systemic
T26326	11060-11065	PRP-DOLLAR-	denotes	their
T26325	11055-11059	IN	denotes	with
T26324	11044-11054	JJ	denotes	consistent
T26323	11035-11043	RB	denotes	probably
T26322	11025-11034	RB	denotes	therefore
T26321	11022-11024	VB	denotes	is
T26320	11020-11021	-COMMA-	denotes	,
T26319	11012-11020	NN	denotes	controls
T26318	11004-11011	JJ	denotes	healthy
T26317	10999-11003	IN	denotes	with
T26316	10990-10998	VB	denotes	compared
T26315	10988-10989	-COMMA-	denotes	,
T26314	10980-10988	NN	denotes	patients
T26313	10977-10979	NN	denotes	RA
T26312	10972-10976	IN	denotes	from
T26311	10966-10971	NN	denotes	cells
T26310	10964-10965	NN	denotes	T
T26309	10959-10963	JJ	denotes	CD4+
T26308	10956-10958	NN	denotes	PB
T26307	10953-10955	IN	denotes	in
T26306	10942-10952	NN	denotes	expression
T26305	10936-10941	NN	denotes	SOCS3
T26304	10930-10935	JJ	denotes	lower
T26303	10925-10929	IN	denotes	with
T26302	10914-10924	NN	denotes	expression
T26301	10908-10913	NN	denotes	SOCS1
T26300	10901-10907	JJ	denotes	Higher
T26299	10898-10899	-RRB-	denotes	]
T26298	10896-10898	CD	denotes	45
T26297	10895-10896	-LRB-	denotes	[
T26296	10885-10894	NN	denotes	pathology
T26295	10877-10884	NN	denotes	disease
T26294	10873-10876	CC	denotes	and
T26293	10866-10872	NN	denotes	levels
T26292	10862-10865	NN	denotes	IgE
T26291	10856-10861	NN	denotes	serum
T26290	10851-10855	IN	denotes	with
T26289	10846-10850	RB	denotes	well
T26288	10835-10845	VB	denotes	correlates
T26287	10824-10834	NN	denotes	expression
T26286	10818-10823	NN	denotes	SOCS3
T26285	10814-10817	DT	denotes	the
T26284	10810-10813	CC	denotes	and
T26283	10808-10809	-COMMA-	denotes	,
T26282	10797-10808	NN	denotes	transcripts
T26281	10791-10796	NN	denotes	SOCS3
T26280	10788-10790	IN	denotes	of
T26279	10781-10787	NN	denotes	levels
T26278	10776-10780	JJ	denotes	high
T26277	10768-10775	VB	denotes	express
T26276	10754-10767	RB	denotes	significantly
T26275	10745-10753	NN	denotes	diseases
T26274	10736-10744	JJ	denotes	allergic
T26273	10731-10735	IN	denotes	with
T26272	10722-10730	NN	denotes	patients
T26271	10717-10721	IN	denotes	from
T26270	10711-10716	NN	denotes	cells
T26269	10709-10710	NN	denotes	T
T26268	10706-10708	NN	denotes	PB
T26267	10704-10705	-COMMA-	denotes	,
T26266	10698-10704	NN	denotes	notion
T26265	10693-10697	DT	denotes	this
T26264	10688-10692	IN	denotes	with
T26263	10677-10687	JJ	denotes	Consistent
T26262	10663-10675	RB	denotes	respectively
T26261	10661-10662	-COMMA-	denotes	,
T26260	10653-10661	NN	denotes	pathways
T26259	10643-10652	NN	denotes	signaling
T26258	10631-10642	NN	denotes	IL-12–STAT4
T26257	10627-10630	DT	denotes	the
T26256	10623-10626	CC	denotes	and
T26255	10612-10622	NN	denotes	IL-4–STAT6
T26254	10608-10611	DT	denotes	the
T26253	10605-10607	IN	denotes	of
T26252	10594-10604	NN	denotes	repressors
T26251	10583-10593	JJ	denotes	cross-talk
T26250	10581-10582	-COMMA-	denotes	,
T26249	10572-10581	JJ	denotes	exclusive
T26248	10563-10571	RB	denotes	mutually
T26247	10561-10562	-COMMA-	denotes	,
T26246	10549-10561	JJ	denotes	Th2-specific
T26245	10545-10548	CC	denotes	and
T26244	10532-10544	JJ	denotes	Th1-specific
T26243	10529-10531	IN	denotes	as
T26242	10523-10528	NN	denotes	roles
T26241	10513-10522	JJ	denotes	important
T26240	10508-10512	VB	denotes	have
T26239	10503-10507	RB	denotes	thus
T26238	10499-10502	MD	denotes	may
T26237	10493-10498	NN	denotes	SOCS3
T26236	10489-10492	CC	denotes	and
T26235	10483-10488	NN	denotes	SOCS1
T26234	10476-10481	NN	denotes	cells
T26233	10472-10475	NN	denotes	Th1
T26232	10469-10471	IN	denotes	in
T26231	10459-10468	NN	denotes	induction
T26230	10453-10458	NN	denotes	SOCS1
T26069	9542-9543	-LRB-	denotes	[
T26068	9530-9541	NN	denotes	macrophages
T26067	9527-9529	IN	denotes	in
T26066	9521-9526	NN	denotes	IL-10
T26065	9518-9520	IN	denotes	of
T26064	9511-9517	NN	denotes	action
T26063	9494-9510	JJ	denotes	immunoregulatory
T26062	9490-9493	DT	denotes	the
T26061	9486-9489	CC	denotes	and
T26060	9475-9485	NN	denotes	inhibition
T26059	9466-9474	NN	denotes	feedback
T26058	9457-9465	JJ	denotes	negative
T26057	9453-9456	DT	denotes	the
T26056	9448-9452	CC	denotes	both
T26055	9444-9447	IN	denotes	for
T26054	9432-9443	JJ	denotes	dispensable
T26053	9429-9431	VB	denotes	is
T26052	9423-9428	NN	denotes	SOCS3
T26051	9421-9422	-COMMA-	denotes	,
T26050	9414-9421	RB	denotes	However
T26049	9411-9412	-RRB-	denotes	]
T26048	9409-9411	CD	denotes	42
T26047	9408-9409	-LRB-	denotes	[
T26046	9399-9407	NN	denotes	response
T26045	9383-9398	JJ	denotes	transcriptional
T26044	9370-9382	JJ	denotes	IL-6-induced
T26043	9366-9369	DT	denotes	the
T26042	9363-9365	IN	denotes	of
T26041	9353-9362	NN	denotes	inhibitor
T26040	9345-9352	JJ	denotes	crucial
T26039	9343-9344	DT	denotes	a
T26038	9340-9342	VB	denotes	is
T26037	9334-9339	NN	denotes	SOCS3
T26036	9329-9333	IN	denotes	that
T26035	9319-9328	VB	denotes	indicated
T26034	9315-9318	VB	denotes	has
T26033	9303-9314	NN	denotes	macrophages
T26032	9287-9302	JJ	denotes	SOCS3-deficient
T26031	9284-9286	IN	denotes	of
T26030	9275-9283	NN	denotes	analysis
T26029	9271-9274	DT	denotes	The
T26028	9268-9269	-RRB-	denotes	]
T26027	9264-9268	CD	denotes	8,41
T26026	9263-9264	-LRB-	denotes	[
T26025	9258-9262	NN	denotes	IL-6
T26024	9255-9257	TO	denotes	to
T26023	9246-9254	NN	denotes	response
T26022	9243-9245	IN	denotes	in
T26021	9237-9242	NN	denotes	STAT3
T26020	9234-9236	IN	denotes	of
T26019	9223-9233	NN	denotes	activation
T26018	9213-9222	JJ	denotes	sustained
T26017	9210-9212	IN	denotes	in
T26016	9202-9209	VB	denotes	results
T26015	9200-9201	-COMMA-	denotes	,
T26014	9190-9200	NN	denotes	deficiency
T26013	9184-9189	NN	denotes	SOCS1
T26012	9180-9183	RB	denotes	not
T26011	9176-9179	CC	denotes	but
T26010	9174-9175	-COMMA-	denotes	,
T26009	9164-9174	NN	denotes	deficiency
T26008	9158-9163	NN	denotes	SOCS3
T26007	9153-9157	IN	denotes	that
T26006	9147-9152	VB	denotes	shown
T26005	9142-9146	VB	denotes	have
T26004	9137-9141	NN	denotes	mice
T26003	9121-9136	JJ	denotes	SOCS3-deficient
T26002	9109-9120	JJ	denotes	conditional
T26001	9106-9108	IN	denotes	of
T26000	9098-9105	NN	denotes	Studies
T25999	9087-9096	NN	denotes	signaling
T25998	9081-9086	NN	denotes	IL-10
T25997	9078-9080	IN	denotes	of
T25996	9074-9077	RB	denotes	not
T25995	9070-9073	CC	denotes	but
T25994	9060-9069	NN	denotes	signaling
T25993	9055-9059	NN	denotes	IL-6
T25992	9052-9054	IN	denotes	of
T25991	9042-9051	NN	denotes	regulator
T25990	9033-9041	JJ	denotes	negative
T25989	9031-9032	DT	denotes	a
T25988	9028-9030	VB	denotes	is
T25987	9022-9027	NN	denotes	SOCS3
T25986	9017-9021	IN	denotes	that
T25985	9008-9016	VB	denotes	revealed
T25984	9002-9007	NN	denotes	SOCS1
T25983	8999-9001	CC	denotes	or
T25982	8993-8998	NN	denotes	SOCS3
T25981	8985-8992	VB	denotes	lacking
T25980	8980-8984	NN	denotes	mice
T25979	8975-8979	IN	denotes	with
T25978	8967-8974	NN	denotes	studies
T25977	8960-8966	JJ	denotes	Recent
T25976	8957-8958	-RRB-	denotes	]
T25975	8956-8957	CD	denotes	7
T25974	8955-8956	-LRB-	denotes	[
T25973	8944-8954	NN	denotes	inhibition
T25972	8934-8943	NN	denotes	crosstalk
T25971	8930-8933	CC	denotes	and
T25970	8921-8929	NN	denotes	feedback
T25969	8912-8920	JJ	denotes	negative
T25968	8909-8911	IN	denotes	of
T25967	8899-8908	NN	denotes	mediators
T25966	8896-8898	IN	denotes	as
T25965	8894-8895	-COMMA-	denotes	,
T25964	8889-8894	NN	denotes	IL-10
T25963	8885-8888	CC	denotes	and
T25962	8880-8884	NN	denotes	IL-6
T25961	8870-8879	VB	denotes	including
T25960	8868-8869	-COMMA-	denotes	,
T25959	8859-8868	NN	denotes	cytokines
T25958	8851-8858	JJ	denotes	various
T25957	8848-8850	IN	denotes	by
T25956	8840-8847	VB	denotes	induced
T25955	8836-8839	VB	denotes	are
T25954	8830-8835	NN	denotes	SOCS3
T25953	8826-8829	CC	denotes	and
T25952	8820-8825	NN	denotes	SOCS1
T25951	8817-8818	-RRB-	denotes	]
T25950	8815-8817	CD	denotes	40
T25949	8814-8815	-LRB-	denotes	[
T25948	8808-8813	NN	denotes	gp130
T25947	8805-8807	IN	denotes	as
T25946	8800-8804	JJ	denotes	such
T25945	8790-8799	NN	denotes	receptors
T25944	8787-8789	IN	denotes	of
T25943	8780-8786	NN	denotes	domain
T25942	8758-8779	JJ	denotes	phosphatase-2-binding
T25941	8749-8757	NN	denotes	homology
T25940	8745-8748	NN	denotes	Src
T25939	8741-8744	DT	denotes	the
T25938	8738-8740	TO	denotes	to
T25937	8730-8737	VB	denotes	binding
T25936	8727-8729	IN	denotes	by
T25935	8723-8726	NN	denotes	JAK
T25934	8720-8722	IN	denotes	of
T25933	8713-8719	NN	denotes	action
T25932	8709-8712	DT	denotes	the
T25931	8700-8708	VB	denotes	inhibits
T25930	8694-8699	NN	denotes	SOCS3
T25929	8690-8693	CC	denotes	and
T25928	8688-8689	-COMMA-	denotes	,
T25927	8685-8688	NN	denotes	JAK
T25926	8682-8684	TO	denotes	to
T25925	8674-8681	VB	denotes	binding
T25924	8665-8673	RB	denotes	directly
T25923	8662-8664	IN	denotes	by
T25922	8658-8661	NN	denotes	JAK
T25921	8655-8657	IN	denotes	of
T25920	8644-8654	NN	denotes	activation
T25919	8635-8643	VB	denotes	prevents
T25918	8629-8634	NN	denotes	SOCS1
T25917	8622-8627	NN	denotes	cells
T25916	8620-8621	NN	denotes	T
T25915	8615-8619	JJ	denotes	CD4+
T25914	8608-8614	JJ	denotes	normal
T25913	8603-8607	IN	denotes	with
T25912	8594-8602	VB	denotes	compared
T25911	8592-8593	-COMMA-	denotes	,
T25910	8587-8592	NN	denotes	SOCS3
T25909	8584-8586	IN	denotes	of
T25908	8577-8583	NN	denotes	levels
T25907	8571-8576	JJ	denotes	lower
T25906	8567-8570	CC	denotes	but
T25905	8565-8566	-COMMA-	denotes	,
T25904	8560-8565	NN	denotes	SOCS1
T25903	8557-8559	IN	denotes	of
T25902	8550-8556	NN	denotes	levels
T25901	8543-8549	JJ	denotes	higher
T25900	8533-8542	VB	denotes	expressed
T25899	8530-8532	NN	denotes	RA
T25898	8523-8529	JJ	denotes	active
T25897	8518-8522	IN	denotes	with
T25896	8509-8517	NN	denotes	patients
T25895	8504-8508	IN	denotes	from
T25894	8498-8503	NN	denotes	cells
T25893	8496-8497	NN	denotes	T
T25892	8491-8495	JJ	denotes	CD4+
T25891	8486-8490	IN	denotes	that
T25890	8480-8485	VB	denotes	found
T25889	8477-8479	PRP	denotes	We
T25888	8474-8475	-RRB-	denotes	]
T25887	8473-8474	CD	denotes	7
T25886	8472-8473	-LRB-	denotes	[
T25885	8463-8471	NN	denotes	proteins
T25884	8456-8462	NN	denotes	family
T25883	8451-8455	NN	denotes	SOCS
T25882	8447-8450	DT	denotes	the
T25881	8444-8446	IN	denotes	by
T25880	8434-8443	VB	denotes	regulated
T25879	8431-8433	VB	denotes	is
T25878	8423-8430	NN	denotes	pathway
T25877	8414-8422	NN	denotes	JAK–STAT
T25876	8410-8413	DT	denotes	the
T25875	8407-8409	IN	denotes	by
T25874	8396-8406	VB	denotes	transduced
T25873	8388-8395	NN	denotes	signals
T25872	8379-8387	NN	denotes	cytokine
T25871	8376-8378	IN	denotes	of
T25870	8366-8375	NN	denotes	longevity
T25869	8362-8365	DT	denotes	The
T25868	8350-8360	NN	denotes	activation
T25867	8344-8349	NN	denotes	STAT3
T25866	8329-8343	JJ	denotes	gp130-mediated
T25865	8321-8328	IN	denotes	through
T25864	8315-8320	NN	denotes	death
T25863	8310-8314	NN	denotes	cell
T25862	8291-8309	JJ	denotes	activation-induced
T25861	8288-8290	TO	denotes	to
T25860	8278-8287	JJ	denotes	resistant
T25859	8274-8277	CC	denotes	and
T25858	8264-8273	VB	denotes	activated
T25857	8252-8263	RB	denotes	chronically
T25856	8248-8251	VB	denotes	are
T25855	8246-8247	-COMMA-	denotes	,
T25854	8240-8246	NN	denotes	subset
T25443	5838-5843	NN	denotes	IL-10
T25442	5828-5837	JJ	denotes	exogenous
T25441	5825-5827	TO	denotes	to
T25440	5813-5824	NN	denotes	sensitivity
T25439	5810-5812	IN	denotes	of
T25438	5805-5809	NN	denotes	loss
T25437	5801-5804	DT	denotes	the
T25436	5798-5800	TO	denotes	to
T25435	5790-5797	VB	denotes	leading
T25434	5788-5789	-COMMA-	denotes	,
T25433	5779-5788	NN	denotes	secretion
T25432	5773-5778	NN	denotes	IL-10
T25431	5769-5772	JJ	denotes	own
T25430	5763-5768	PRP-DOLLAR-	denotes	their
T25429	5760-5762	IN	denotes	by
T25428	5754-5759	NN	denotes	cells
T25427	5752-5753	NN	denotes	T
T25426	5747-5751	JJ	denotes	CD4+
T25425	5744-5746	IN	denotes	in
T25424	5736-5743	VB	denotes	induced
T25423	5721-5735	RB	denotes	constitutively
T25422	5718-5720	VB	denotes	be
T25421	5712-5717	MD	denotes	could
T25420	5703-5711	NN	denotes	activity
T25419	5697-5702	NN	denotes	STAT3
T25418	5692-5696	IN	denotes	that
T25417	5683-5691	JJ	denotes	possible
T25416	5678-5682	RB	denotes	also
T25415	5675-5677	VB	denotes	is
T25414	5672-5674	PRP	denotes	it
T25413	5670-5671	-COMMA-	denotes	,
T25412	5663-5670	RB	denotes	However
T25411	5657-5661	NN	denotes	IL-6
T25410	5651-5656	NN	denotes	serum
T25409	5648-5650	IN	denotes	of
T25408	5633-5647	NN	denotes	concentrations
T25407	5628-5632	JJ	denotes	high
T25406	5625-5627	TO	denotes	to
T25405	5620-5624	FW	denotes	vivo
T25404	5617-5619	FW	denotes	in
T25403	5608-5616	NN	denotes	exposure
T25402	5600-5607	JJ	denotes	chronic
T25401	5594-5599	IN	denotes	after
T25400	5586-5593	VB	denotes	induced
T25399	5583-5585	VB	denotes	be
T25398	5579-5582	MD	denotes	may
T25397	5573-5578	NN	denotes	cells
T25396	5571-5572	NN	denotes	T
T25395	5566-5570	JJ	denotes	CD4+
T25394	5563-5565	NN	denotes	RA
T25393	5560-5562	IN	denotes	in
T25392	5554-5559	VB	denotes	found
T25391	5543-5553	NN	denotes	inhibition
T25390	5537-5542	NN	denotes	IL-10
T25389	5534-5536	TO	denotes	to
T25388	5523-5533	NN	denotes	resistance
T25387	5519-5522	DT	denotes	the
T25386	5515-5518	CC	denotes	and
T25385	5504-5514	NN	denotes	activation
T25384	5498-5503	NN	denotes	STAT3
T25383	5488-5497	JJ	denotes	sustained
T25382	5484-5487	DT	denotes	the
T25381	5479-5483	CC	denotes	both
T25380	5474-5478	IN	denotes	that
T25379	5466-5473	VB	denotes	suggest
T25378	5458-5465	NN	denotes	results
T25377	5452-5457	DT	denotes	These
T25376	5446-5450	NN	denotes	IL-6
T25375	5441-5445	IN	denotes	with
T25374	5430-5440	NN	denotes	incubation
T25373	5427-5429	IN	denotes	of
T25372	5421-5426	NN	denotes	hours
T25371	5418-5420	CD	denotes	36
T25370	5412-5417	IN	denotes	after
T25369	5406-5411	NN	denotes	cells
T25368	5404-5405	NN	denotes	T
T25367	5399-5403	JJ	denotes	CD4+
T25366	5392-5398	JJ	denotes	normal
T25365	5389-5391	IN	denotes	in
T25364	5378-5388	VB	denotes	suppressed
T25363	5374-5377	VB	denotes	was
T25362	5368-5373	NN	denotes	IL-10
T25361	5365-5367	TO	denotes	to
T25360	5350-5364	NN	denotes	responsiveness
T25359	5346-5349	DT	denotes	the
T25358	5342-5345	CC	denotes	and
T25357	5340-5341	-COMMA-	denotes	,
T25356	5332-5340	NN	denotes	patients
T25355	5329-5331	NN	denotes	RA
T25354	5322-5328	JJ	denotes	active
T25353	5319-5321	IN	denotes	of
T25352	5313-5318	NN	denotes	serum
T25351	5309-5312	DT	denotes	the
T25350	5306-5308	IN	denotes	in
T25349	5296-5305	VB	denotes	contained
T25348	5289-5295	NN	denotes	factor
T25347	5272-5288	JJ	denotes	STAT3-activating
T25346	5266-5271	JJ	denotes	major
T25345	5262-5265	DT	denotes	the
T25344	5258-5261	VB	denotes	was
T25343	5253-5257	NN	denotes	IL-6
T25342	5251-5252	-COMMA-	denotes	,
T25341	5245-5251	NN	denotes	notion
T25340	5240-5244	DT	denotes	this
T25339	5235-5239	IN	denotes	with
T25338	5224-5234	JJ	denotes	Consistent
T25337	5221-5222	-RRB-	denotes	]
T25336	5219-5221	CD	denotes	27
T25335	5218-5219	-LRB-	denotes	[
T25334	5206-5217	NN	denotes	circulation
T25333	5200-5205	NN	denotes	blood
T25332	5196-5199	DT	denotes	the
T25331	5193-5195	IN	denotes	in
T25330	5183-5192	NN	denotes	abundance
T25329	5179-5182	PRP-DOLLAR-	denotes	its
T25328	5176-5178	TO	denotes	to
T25327	5169-5175	RB	denotes	mainly
T25326	5165-5168	JJ	denotes	due
T25325	5163-5164	-COMMA-	denotes	,
T25324	5161-5163	NN	denotes	RA
T25323	5154-5160	JJ	denotes	active
T25322	5151-5153	IN	denotes	in
T25321	5142-5150	NN	denotes	response
T25320	5136-5141	NN	denotes	phase
T25319	5130-5135	JJ	denotes	acute
T25318	5126-5129	DT	denotes	the
T25317	5123-5125	IN	denotes	as
T25316	5118-5122	JJ	denotes	such
T25315	5109-5117	NN	denotes	reaction
T25314	5100-5108	JJ	denotes	systemic
T25313	5098-5099	DT	denotes	a
T25312	5088-5097	VB	denotes	eliciting
T25311	5085-5087	IN	denotes	in
T25310	5080-5084	NN	denotes	role
T25309	5068-5079	JJ	denotes	predominant
T25308	5066-5067	DT	denotes	a
T25307	5060-5065	VB	denotes	plays
T25306	5055-5059	NN	denotes	IL-6
T25305	5053-5054	-COMMA-	denotes	,
T25304	5044-5053	NN	denotes	cytokines
T25303	5038-5043	DT	denotes	these
T25302	5035-5037	IN	denotes	Of
T25301	5032-5033	-RRB-	denotes	]
T25300	5031-5032	CD	denotes	4
T25299	5030-5031	-LRB-	denotes	[
T25298	5024-5029	NN	denotes	IL-10
T25297	5021-5023	TO	denotes	to
T25296	5012-5020	NN	denotes	addition
T25295	5009-5011	IN	denotes	in
T25294	5007-5008	-COMMA-	denotes	,
T25293	5000-5007	NN	denotes	factors
T25292	4993-4999	NN	denotes	growth
T25291	4989-4992	CC	denotes	and
T25290	4987-4988	-RRB-	denotes	)
T25289	4986-4987	NN	denotes	M
T25288	4975-4985	NN	denotes	oncostatin
T25287	4971-4974	CC	denotes	and
T25286	4969-4970	-COMMA-	denotes	,
T25285	4963-4969	NN	denotes	factor
T25284	4952-4962	JJ	denotes	inhibitory
T25283	4943-4951	NN	denotes	leukemia
T25282	4941-4942	-COMMA-	denotes	,
T25281	4936-4941	NN	denotes	IL-11
T25280	4934-4935	-COMMA-	denotes	,
T25279	4930-4934	NN	denotes	IL-6
T25278	4925-4929	FW	denotes	e.g.
T25277	4924-4925	-LRB-	denotes	(
T25276	4914-4923	NN	denotes	cytokines
T25275	4911-4913	IN	denotes	of
T25274	4904-4910	NN	denotes	family
T25273	4899-4903	NN	denotes	IL-6
T25272	4895-4898	DT	denotes	the
T25271	4887-4894	RB	denotes	notably
T25270	4885-4886	-COMMA-	denotes	,
T25269	4876-4885	NN	denotes	cytokines
T25268	4873-4875	IN	denotes	of
T25267	4865-4872	NN	denotes	variety
T25266	4863-4864	DT	denotes	a
T25265	4860-4862	IN	denotes	by
T25264	4850-4859	VB	denotes	activated
T25263	4847-4849	VB	denotes	is
T25262	4841-4846	NN	denotes	STAT3
T25261	4831-4839	NN	denotes	patients
T25260	4828-4830	NN	denotes	RA
T26229	10450-10452	IN	denotes	by
T26228	10439-10449	VB	denotes	diminished
T26227	10436-10438	VB	denotes	is
T26226	10426-10435	NN	denotes	signaling
T26225	10420-10425	NN	denotes	STAT6
T26224	10407-10419	JJ	denotes	IL-4-induced
T26223	10399-10406	IN	denotes	whereas
T26222	10397-10398	-COMMA-	denotes	,
T26221	10392-10397	NN	denotes	cells
T26220	10388-10391	NN	denotes	Th2
T26219	10385-10387	IN	denotes	in
T26218	10375-10384	NN	denotes	induction
T26217	10369-10374	NN	denotes	SOCS3
T26216	10366-10368	IN	denotes	by
T26215	10356-10365	VB	denotes	inhibited
T26214	10353-10355	VB	denotes	is
T26213	10342-10352	NN	denotes	activation
T26212	10336-10341	NN	denotes	STAT4
T26211	10322-10335	JJ	denotes	IL-12-induced
T26210	10319-10320	-RRB-	denotes	]
T26209	10317-10319	CD	denotes	44
T26208	10316-10317	-LRB-	denotes	[
T26207	10303-10315	RB	denotes	respectively
T26206	10301-10302	-COMMA-	denotes	,
T26205	10297-10301	NN	denotes	mRNA
T26204	10291-10296	NN	denotes	SOCS3
T26203	10287-10290	CC	denotes	and
T26202	10281-10286	NN	denotes	SOCS1
T26201	10278-10280	IN	denotes	of
T26200	10271-10277	NN	denotes	levels
T26199	10266-10270	JJ	denotes	high
T26198	10258-10265	VB	denotes	express
T26197	10252-10257	NN	denotes	cells
T26196	10248-10251	NN	denotes	Th2
T26195	10244-10247	CC	denotes	and
T26194	10240-10243	NN	denotes	Th1
T26193	10230-10239	VB	denotes	polarized
T26192	10225-10229	IN	denotes	that
T26191	10216-10224	VB	denotes	indicate
T26190	10213-10215	TO	denotes	to
T26189	10206-10212	NN	denotes	regard
T26188	10201-10205	DT	denotes	this
T26187	10198-10200	IN	denotes	in
T26186	10189-10197	NN	denotes	interest
T26185	10186-10188	IN	denotes	of
T26184	10183-10185	VB	denotes	is
T26183	10180-10182	PRP	denotes	It
T26182	10177-10178	-RRB-	denotes	]
T26181	10175-10177	CD	denotes	32
T26180	10174-10175	-LRB-	denotes	[
T26179	10168-10173	NN	denotes	SOCS1
T26178	10165-10167	IN	denotes	of
T26177	10157-10164	NN	denotes	inducer
T26176	10150-10156	JJ	denotes	potent
T26175	10148-10149	DT	denotes	a
T26174	10145-10147	IN	denotes	as
T26173	10139-10144	VB	denotes	known
T26172	10134-10138	VB	denotes	been
T26171	10130-10133	VB	denotes	has
T26170	10124-10129	NN	denotes	IFN-γ
T26169	10116-10123	IN	denotes	because
T26168	10112-10115	CC	denotes	and
T26167	10110-10111	-COMMA-	denotes	,
T26166	10105-10110	NN	denotes	IL-10
T26165	10102-10104	IN	denotes	of
T26164	10093-10101	NN	denotes	presence
T26163	10089-10092	DT	denotes	the
T26162	10086-10088	IN	denotes	in
T26161	10080-10085	NN	denotes	IFN-γ
T26160	10077-10079	IN	denotes	of
T26159	10070-10076	NN	denotes	levels
T26158	10065-10069	JJ	denotes	high
T26157	10057-10064	VB	denotes	produce
T26156	10051-10056	MD	denotes	could
T26155	10048-10050	NN	denotes	RA
T26154	10041-10047	JJ	denotes	active
T26153	10036-10040	IN	denotes	from
T26152	10030-10035	NN	denotes	cells
T26151	10028-10029	NN	denotes	T
T26150	10023-10027	JJ	denotes	CD4+
T26149	10015-10022	IN	denotes	because
T26148	10013-10014	-COMMA-	denotes	,
T26147	10008-10013	NN	denotes	IFN-γ
T26146	10000-10007	VB	denotes	produce
T26145	9997-9999	TO	denotes	to
T26144	9991-9996	NN	denotes	cells
T26143	9989-9990	NN	denotes	T
T26142	9984-9988	JJ	denotes	CD4+
T26141	9981-9983	IN	denotes	of
T26140	9973-9980	NN	denotes	ability
T26139	9969-9972	DT	denotes	the
T26138	9964-9968	IN	denotes	with
T26137	9953-9963	VB	denotes	associated
T26136	9950-9952	VB	denotes	be
T26135	9946-9949	MD	denotes	may
T26134	9936-9945	NN	denotes	induction
T26133	9930-9935	NN	denotes	SOCS1
T26132	9925-9929	IN	denotes	that
T26131	9913-9924	NN	denotes	possibility
T26130	9911-9912	DT	denotes	a
T26129	9908-9910	VB	denotes	is
T26128	9902-9907	EX	denotes	There
T26127	9896-9900	NN	denotes	IL-6
T26126	9890-9895	NN	denotes	serum
T26125	9887-9889	TO	denotes	to
T26124	9878-9886	NN	denotes	response
T26123	9875-9877	IN	denotes	in
T26122	9864-9874	NN	denotes	activation
T26121	9858-9863	NN	denotes	STAT3
T26120	9847-9857	JJ	denotes	persistent
T26119	9843-9846	IN	denotes	for
T26118	9831-9842	JJ	denotes	responsible
T26117	9828-9830	VB	denotes	be
T26116	9824-9827	MD	denotes	may
T26115	9813-9823	NN	denotes	expression
T26114	9807-9812	NN	denotes	SOCS3
T26113	9797-9806	JJ	denotes	defective
T26112	9793-9796	CC	denotes	and
T26111	9791-9792	-COMMA-	denotes	,
T26110	9781-9791	NN	denotes	activation
T26109	9775-9780	NN	denotes	STAT3
T26108	9760-9774	JJ	denotes	IL-10-mediated
T26107	9757-9759	TO	denotes	to
T26106	9753-9756	CC	denotes	and
T26105	9747-9752	NN	denotes	IL-10
T26104	9744-9746	TO	denotes	to
T26103	9729-9743	NN	denotes	responsiveness
T26102	9720-9728	JJ	denotes	impaired
T26101	9716-9719	DT	denotes	the
T26100	9711-9715	CC	denotes	both
T26099	9706-9710	IN	denotes	with
T26098	9695-9705	VB	denotes	associated
T26097	9692-9694	VB	denotes	be
T26096	9682-9691	RB	denotes	therefore
T26095	9678-9681	MD	denotes	may
T26094	9672-9677	NN	denotes	cells
T26093	9670-9671	NN	denotes	T
T26092	9665-9669	JJ	denotes	CD4+
T26091	9662-9664	NN	denotes	RA
T26090	9659-9661	IN	denotes	in
T26089	9648-9658	NN	denotes	expression
T26088	9642-9647	NN	denotes	SOCS1
T26087	9632-9641	VB	denotes	Increased
T26086	9629-9630	-RRB-	denotes	]
T26085	9627-9629	CD	denotes	43
T26084	9626-9627	-LRB-	denotes	[
T26083	9616-9625	NN	denotes	signaling
T26082	9601-9615	JJ	denotes	IL-10-mediated
T26081	9593-9600	VB	denotes	inhibit
T26080	9584-9592	RB	denotes	directly
T26079	9581-9583	TO	denotes	to
T26078	9575-9580	VB	denotes	found
T26077	9571-9574	VB	denotes	was
T26076	9565-9570	NN	denotes	SOCS1
T26075	9563-9564	-COMMA-	denotes	,
T26074	9555-9563	NN	denotes	contrary
T26073	9551-9554	DT	denotes	the
T26072	9548-9550	IN	denotes	On
T26071	9545-9546	-RRB-	denotes	]
T26070	9543-9545	CD	denotes	41
T25259	4823-4827	IN	denotes	from
T25258	4817-4822	NN	denotes	cells
T25257	4815-4816	NN	denotes	T
T25256	4810-4814	JJ	denotes	CD4+
T25255	4807-4809	JJ	denotes	ST
T25254	4803-4806	CC	denotes	and
T25253	4800-4802	NN	denotes	PB
T25252	4791-4799	VB	denotes	isolated
T25251	4783-4790	RB	denotes	freshly
T25250	4780-4782	IN	denotes	in
T25249	4778-4779	-RRB-	denotes	)
T25248	4773-4778	NN	denotes	hours
T25247	4771-4772	CD	denotes	6
T25246	4768-4770	TO	denotes	to
T25245	4765-4767	RB	denotes	up
T25244	4764-4765	-LRB-	denotes	(
T25243	4751-4763	RB	denotes	persistently
T25242	4736-4750	VB	denotes	phosphorylated
T25241	4727-4735	NN	denotes	tyrosine
T25240	4724-4726	VB	denotes	be
T25239	4721-4723	TO	denotes	to
T25238	4715-4720	VB	denotes	found
T25237	4711-4714	VB	denotes	was
T25236	4705-4710	NN	denotes	STAT3
T25235	4703-4704	-COMMA-	denotes	,
T25234	4693-4703	NN	denotes	activation
T25233	4687-4692	NN	denotes	STAT3
T25232	4672-4686	JJ	denotes	IL-10-mediated
T25231	4663-4671	JJ	denotes	impaired
T25230	4658-4662	IN	denotes	with
T25229	4646-4657	NN	denotes	association
T25228	4643-4645	IN	denotes	In
T25194	4391-4400	JJ	denotes	defective
T25193	4386-4390	IN	denotes	with
T25192	4375-4385	VB	denotes	associated
T25191	4372-4374	VB	denotes	be
T25190	4368-4371	MD	denotes	may
T25189	4362-4367	NN	denotes	IL-10
T25188	4359-4361	TO	denotes	to
T25187	4353-4358	NN	denotes	cells
T25186	4351-4352	NN	denotes	T
T25185	4346-4350	JJ	denotes	CD4+
T25184	4343-4345	NN	denotes	RA
T25183	4340-4342	IN	denotes	of
T25182	4329-4339	NN	denotes	resistance
T25181	4325-4328	DT	denotes	the
T25180	4320-4324	IN	denotes	that
T25179	4307-4319	VB	denotes	demonstrated
T25178	4302-4306	VB	denotes	have
T25177	4299-4301	PRP	denotes	We
T25176	4296-4297	-RRB-	denotes	]
T25175	4294-4296	CD	denotes	15
T25174	4293-4294	-LRB-	denotes	[
T25173	4286-4292	NN	denotes	factor
T25172	4267-4285	JJ	denotes	colony-stimulating
T25171	4244-4266	JJ	denotes	granulocyte–macrophage
T25170	4240-4243	CC	denotes	and
T25169	4238-4239	-COMMA-	denotes	,
T25168	4234-4238	NN	denotes	IL-1
T25167	4232-4233	-COMMA-	denotes	,
T25166	4227-4232	NN	denotes	TNF-α
T25165	4224-4226	IN	denotes	as
T25164	4219-4223	JJ	denotes	such
T25163	4211-4218	NN	denotes	stimuli
T25162	4202-4210	NN	denotes	cytokine
T25161	4186-4201	JJ	denotes	proinflammatory
T25160	4183-4185	IN	denotes	of
T25159	4174-4182	NN	denotes	presence
T25158	4170-4173	DT	denotes	the
T25157	4167-4169	IN	denotes	in
T25156	4159-4166	NN	denotes	IL-10R1
T25155	4145-4158	JJ	denotes	intracellular
T25154	4142-4144	IN	denotes	of
T25153	4132-4141	NN	denotes	transport
T25152	4122-4131	VB	denotes	decreased
T25151	4119-4121	TO	denotes	to
T25150	4115-4118	JJ	denotes	due
T25149	4109-4114	NN	denotes	IL-10
T25148	4106-4108	IN	denotes	of
T25147	4099-4105	NN	denotes	effect
T25146	4082-4098	JJ	denotes	immunoregulatory
T25145	4078-4081	DT	denotes	the
T25144	4075-4077	TO	denotes	to
T25143	4065-4074	JJ	denotes	resistant
T25142	4061-4064	VB	denotes	are
T25141	4054-4060	NN	denotes	fluids
T25140	4045-4053	JJ	denotes	synovial
T25139	4042-4044	NN	denotes	RA
T25138	4037-4041	IN	denotes	from
T25137	4031-4036	NN	denotes	cells
T25136	4021-4030	JJ	denotes	dendritic
T25135	4019-4020	-COMMA-	denotes	,
T25134	4008-4019	RB	denotes	Furthermore
T25133	4005-4006	-RRB-	denotes	]
T25132	4003-4005	CD	denotes	14
T25131	4002-4003	-LRB-	denotes	[
T25130	3993-4001	NN	denotes	receptor
T25129	3987-3992	NN	denotes	gamma
T25128	3984-3986	NN	denotes	Fc
T25127	3980-3983	NN	denotes	IgG
T25126	3976-3979	DT	denotes	the
T25125	3973-3975	IN	denotes	of
T25124	3964-3972	NN	denotes	ligation
T25123	3954-3963	VB	denotes	following
T25122	3946-3953	NN	denotes	pathway
T25121	3934-3945	JJ	denotes	C-dependent
T25120	3927-3933	NN	denotes	kinase
T25119	3919-3926	NN	denotes	protein
T25118	3917-3918	DT	denotes	a
T25117	3914-3916	IN	denotes	by
T25116	3902-3913	NN	denotes	macrophages
T25115	3889-3901	JJ	denotes	IFN-γ-primed
T25114	3886-3888	IN	denotes	in
T25113	3875-3885	VB	denotes	suppressed
T25112	3871-3874	VB	denotes	are
T25111	3860-3870	NN	denotes	activation
T25110	3855-3859	NN	denotes	Jak1
T25109	3841-3854	JJ	denotes	IL-10-induced
T25108	3837-3840	CC	denotes	and
T25107	3826-3836	NN	denotes	expression
T25106	3818-3825	NN	denotes	IL-10R1
T25105	3810-3817	NN	denotes	surface
T25104	3805-3809	NN	denotes	cell
T25103	3800-3804	CC	denotes	both
T25102	3792-3799	IN	denotes	because
T25101	3790-3791	-COMMA-	denotes	,
T25100	3786-3790	FW	denotes	vivo
T25099	3783-3785	FW	denotes	in
T25098	3773-3782	NN	denotes	complexes
T25097	3766-3772	JJ	denotes	immune
T25096	3763-3765	TO	denotes	to
T25095	3754-3762	NN	denotes	exposure
T25094	3746-3753	JJ	denotes	chronic
T25093	3743-3745	IN	denotes	by
T25092	3735-3742	VB	denotes	induced
T25091	3726-3734	RB	denotes	probably
T25090	3723-3725	VB	denotes	is
T25089	3713-3722	NN	denotes	signaling
T25088	3707-3712	NN	denotes	IL-10
T25087	3698-3706	JJ	denotes	impaired
T25086	3693-3697	DT	denotes	This
T25085	3680-3691	NN	denotes	macrophages
T25084	3671-3679	JJ	denotes	synovial
T25083	3668-3670	NN	denotes	RA
T25082	3665-3667	IN	denotes	in
T25081	3652-3664	JJ	denotes	undetectable
T25080	3645-3651	RB	denotes	mostly
T25079	3642-3644	VB	denotes	is
T25078	3631-3641	NN	denotes	activation
T25077	3625-3630	NN	denotes	STAT3
T25076	3610-3624	JJ	denotes	IL-10-mediated
T25075	3608-3609	-COMMA-	denotes	,
T25074	3597-3608	RB	denotes	importantly
T25073	3592-3596	RB	denotes	More
T25072	3589-3590	-RRB-	denotes	]
T25071	3587-3589	CD	denotes	13
T25070	3586-3587	-LRB-	denotes	[
T25069	3574-3585	NN	denotes	macrophages
T25068	3566-3573	JJ	denotes	adhered
T25067	3563-3565	IN	denotes	in
T25066	3558-3562	NN	denotes	IL-6
T25065	3554-3557	CC	denotes	and
T25064	3548-3553	NN	denotes	IL-10
T25063	3545-3547	IN	denotes	by
T25062	3538-3544	VB	denotes	shared
T25061	3530-3537	NN	denotes	pathway
T25060	3520-3529	NN	denotes	signaling
T25059	3509-3519	NN	denotes	Jak1–STAT3
T25058	3505-3508	DT	denotes	the
T25057	3496-3504	VB	denotes	inhibits
T25056	3494-3495	-COMMA-	denotes	,
T25055	3490-3494	NN	denotes	IL-1
T25054	3486-3489	CC	denotes	and
T25053	3480-3485	NN	denotes	TNF-α
T25052	3477-3479	IN	denotes	by
T25051	3469-3476	VB	denotes	induced
T25050	3467-3468	-COMMA-	denotes	,
T25049	3459-3467	NN	denotes	pathways
T25048	3452-3458	NN	denotes	kinase
T25047	3448-3451	NN	denotes	p38
T25046	3444-3447	CC	denotes	and
T25045	3437-3443	NN	denotes	kinase
T25044	3418-3436	JJ	denotes	stimulus-regulated
T25043	3404-3417	JJ	denotes	extracellular
T25042	3400-3403	DT	denotes	the
T25041	3395-3399	CC	denotes	both
T25040	3392-3394	IN	denotes	of
T25039	3381-3391	NN	denotes	activation
T25038	3377-3380	DT	denotes	The
T25037	3363-3375	NN	denotes	inflammation
T25036	3355-3362	JJ	denotes	chronic
T25035	3348-3354	IN	denotes	during
T25034	3337-3347	VB	denotes	restricted
T25033	3334-3336	VB	denotes	be
T25032	3331-3333	TO	denotes	to
T25031	3325-3330	VB	denotes	seems
T25030	3316-3324	NN	denotes	activity
T25029	3305-3315	JJ	denotes	regulatory
T25028	3300-3304	DT	denotes	this
T25027	3298-3299	-COMMA-	denotes	,
T25026	3291-3298	RB	denotes	However
T25025	3288-3289	-RRB-	denotes	]
T25024	3286-3288	CD	denotes	12
T25023	3285-3286	-LRB-	denotes	[
T25022	3279-3284	NN	denotes	cells
T25021	3276-3278	JJ	denotes	ST
T25020	3273-3275	IN	denotes	by
T25019	3262-3272	NN	denotes	production
T25018	3253-3261	NN	denotes	cytokine
T25017	3237-3252	JJ	denotes	proinflammatory
T25016	3228-3236	VB	denotes	inhibits
T25015	3226-3227	-COMMA-	denotes	,
T25014	3221-3226	NN	denotes	cells
T25013	3219-3220	NN	denotes	T
T25012	3215-3218	CC	denotes	and
T25011	3203-3214	NN	denotes	macrophages
T25853	8233-8239	NN	denotes	T-cell
T25852	8228-8232	JJ	denotes	CD4+
T25851	8224-8227	DT	denotes	the
T25850	8211-8223	RB	denotes	particularly
T25849	8209-8210	-COMMA-	denotes	,
T25848	8204-8209	NN	denotes	cells
T25847	8202-8203	NN	denotes	T
T25846	8200-8201	-COMMA-	denotes	,
T25845	8196-8200	NN	denotes	mice
T25844	8181-8195	NN	denotes	gp130F759/F759
T25843	8177-8180	DT	denotes	the
T25842	8174-8176	IN	denotes	In
T25841	8171-8172	-RRB-	denotes	]
T25840	8169-8171	CD	denotes	39
T25839	8168-8169	-LRB-	denotes	[
T25838	8154-8167	NN	denotes	phenylalanine
T25837	8151-8153	TO	denotes	to
T25836	8143-8150	VB	denotes	mutated
T25835	8139-8142	VB	denotes	was
T25834	8137-8138	-COMMA-	denotes	,
T25833	8134-8137	CD	denotes	759
T25832	8125-8133	NN	denotes	tyrosine
T25831	8123-8124	-COMMA-	denotes	,
T25830	8122-8123	-RRB-	denotes	)
T25829	8114-8122	NN	denotes	receptor
T25828	8105-8113	NN	denotes	cytokine
T25827	8098-8104	NN	denotes	family
T25826	8093-8097	NN	denotes	IL-6
T25825	8089-8092	DT	denotes	the
T25824	8086-8088	IN	denotes	of
T25823	8078-8085	NN	denotes	subunit
T25822	8076-8077	NN	denotes	β
T25821	8063-8075	NN	denotes	glycoprotein
T25820	8049-8062	NN	denotes	transmembrane
T25819	8045-8048	DT	denotes	the
T25818	8044-8045	-LRB-	denotes	(
T25817	8038-8043	NN	denotes	gp130
T25816	8035-8037	IN	denotes	of
T25815	8030-8034	NN	denotes	site
T25814	8022-8029	NN	denotes	binding
T25813	8008-8021	NN	denotes	phosphatase-2
T25812	7999-8007	NN	denotes	homology
T25811	7995-7998	NN	denotes	Src
T25810	7991-7994	DT	denotes	the
T25809	7985-7990	WDT	denotes	which
T25808	7982-7984	IN	denotes	in
T25807	7980-7981	-COMMA-	denotes	,
T25806	7976-7980	NN	denotes	mice
T25805	7961-7975	NN	denotes	gp130F759/F759
T25804	7957-7960	DT	denotes	the
T25803	7954-7956	IN	denotes	of
T25802	7946-7953	NN	denotes	studies
T25801	7943-7945	IN	denotes	by
T25800	7933-7942	VB	denotes	suggested
T25799	7928-7932	VB	denotes	been
T25798	7924-7927	VB	denotes	has
T25797	7914-7923	NN	denotes	arthritis
T25796	7903-7913	JJ	denotes	autoimmune
T25795	7884-7902	JJ	denotes	Th1-cell-dominated
T25633	6948-6950	VB	denotes	be
T25632	6938-6947	RB	denotes	therefore
T25631	6934-6937	MD	denotes	may
T25630	6928-6933	NN	denotes	IL-10
T25629	6925-6927	IN	denotes	of
T25628	6918-6924	NN	denotes	effect
T25627	6900-6917	JJ	denotes	T-cell-inhibitory
T25626	6896-6899	DT	denotes	The
T25625	6893-6894	-RRB-	denotes	]
T25624	6891-6893	CD	denotes	32
T25623	6890-6891	-LRB-	denotes	[
T25622	6880-6889	NN	denotes	signaling
T25621	6874-6879	NN	denotes	IL-10
T25620	6871-6873	IN	denotes	of
T25619	6861-6870	NN	denotes	inhibitor
T25618	6851-6860	NN	denotes	crosstalk
T25617	6849-6850	DT	denotes	a
T25616	6846-6848	IN	denotes	as
T25615	6838-6845	NN	denotes	protein
T25614	6832-6837	NN	denotes	SOCS1
T25613	6825-6831	VB	denotes	induce
T25612	6821-6824	MD	denotes	can
T25611	6815-6820	NN	denotes	IFN-γ
T25610	6811-6814	CC	denotes	and
T25609	6800-6810	NN	denotes	activation
T25608	6794-6799	NN	denotes	STAT3
T25607	6784-6793	VB	denotes	stimulate
T25606	6771-6783	RB	denotes	persistently
T25605	6767-6770	MD	denotes	may
T25604	6761-6766	NN	denotes	IL-10
T25603	6759-6760	-COMMA-	denotes	,
T25602	6752-6759	NN	denotes	fashion
T25601	6742-6751	JJ	denotes	autocrine
T25600	6739-6741	DT	denotes	an
T25599	6736-6738	IN	denotes	In
T25598	6733-6734	-RRB-	denotes	]
T25597	6728-6733	CD	denotes	34,35
T25596	6727-6728	-LRB-	denotes	[
T25595	6717-6726	NN	denotes	cytokines
T25594	6712-6716	DT	denotes	both
T25593	6704-6711	VB	denotes	produce
T25592	6692-6703	NN	denotes	infiltrates
T25591	6685-6691	NN	denotes	T-cell
T25590	6677-6684	IN	denotes	because
T25589	6675-6676	-COMMA-	denotes	,
T25588	6673-6675	NN	denotes	ST
T25587	6669-6672	DT	denotes	the
T25586	6666-6668	IN	denotes	in
T25585	6656-6665	NN	denotes	signaling
T25584	6650-6655	NN	denotes	IL-10
T25583	6641-6649	JJ	denotes	impaired
T25582	6637-6640	IN	denotes	for
T25581	6625-6636	JJ	denotes	responsible
T25580	6622-6624	VB	denotes	be
T25579	6616-6621	MD	denotes	could
T25578	6605-6615	PRP	denotes	themselves
T25577	6599-6604	NN	denotes	cells
T25576	6597-6598	NN	denotes	T
T25575	6592-6596	JJ	denotes	CD4+
T25574	6589-6591	IN	denotes	by
T25573	6580-6588	VB	denotes	produced
T25572	6574-6579	NN	denotes	IL-10
T25571	6570-6573	CC	denotes	and
T25570	6564-6569	NN	denotes	IFN-γ
T25569	6562-6563	-COMMA-	denotes	,
T25568	6551-6562	RB	denotes	Furthermore
T25567	6548-6549	-RRB-	denotes	)
T25566	6543-6548	VB	denotes	shown
T25565	6539-6542	RB	denotes	not
T25564	6534-6538	NN	denotes	data
T25563	6533-6534	-LRB-	denotes	(
T25562	6528-6532	NN	denotes	IL-6
T25561	6525-6527	IN	denotes	by
T25560	6520-6524	IN	denotes	than
T25559	6508-6519	RB	denotes	effectively
T25558	6503-6507	RB	denotes	less
T25557	6494-6502	IN	denotes	although
T25556	6492-6493	-COMMA-	denotes	,
T25555	6487-6492	NN	denotes	TNF-α
T25554	6483-6486	CC	denotes	and
T25553	6477-6482	NN	denotes	IL-1β
T25552	6472-6476	IN	denotes	with
T25551	6459-6471	NN	denotes	pretreatment
T25550	6456-6458	IN	denotes	by
T25549	6448-6455	VB	denotes	reduced
T25548	6444-6447	VB	denotes	was
T25547	6438-6443	NN	denotes	cells
T25546	6436-6437	NN	denotes	T
T25545	6431-6435	JJ	denotes	CD4+
T25544	6428-6430	IN	denotes	in
T25543	6417-6427	NN	denotes	inhibition
T25542	6411-6416	NN	denotes	IFN-γ
T25541	6396-6410	JJ	denotes	IL-10-mediated
T25540	6391-6395	IN	denotes	that
T25539	6377-6390	VB	denotes	demonstrating
T25538	6365-6376	NN	denotes	experiments
T25537	6353-6364	JJ	denotes	preliminary
T25536	6349-6352	PRP-DOLLAR-	denotes	our
T25535	6346-6348	IN	denotes	by
T25534	6336-6345	VB	denotes	suggested
T25533	6332-6335	VB	denotes	was
T25532	6324-6331	NN	denotes	process
T25531	6319-6323	DT	denotes	this
T25530	6316-6318	IN	denotes	in
T25529	6306-6315	NN	denotes	cytokines
T25528	6290-6305	JJ	denotes	proinflammatory
T25527	6280-6289	JJ	denotes	essential
T25526	6274-6279	JJ	denotes	other
T25525	6271-6273	IN	denotes	of
T25524	6259-6270	NN	denotes	involvement
T25523	6255-6258	DT	denotes	the
T25522	6253-6254	-COMMA-	denotes	,
T25521	6245-6253	NN	denotes	addition
T25520	6242-6244	IN	denotes	In
T25519	6239-6240	-RRB-	denotes	]
T25518	6237-6239	CD	denotes	27
T25517	6236-6237	-LRB-	denotes	[
T25516	6230-6235	NN	denotes	level
T25515	6224-6229	NN	denotes	blood
T25514	6220-6223	DT	denotes	the
T25513	6215-6219	IN	denotes	with
T25512	6206-6214	VB	denotes	compared
T25511	6193-6205	VB	denotes	concentrated
T25510	6186-6192	RB	denotes	highly
T25509	6183-6185	VB	denotes	is
T25508	6178-6182	NN	denotes	IL-6
T25507	6170-6177	IN	denotes	because
T25506	6168-6169	-COMMA-	denotes	,
T25505	6166-6168	NN	denotes	ST
T25504	6157-6165	JJ	denotes	inflamed
T25503	6153-6156	DT	denotes	the
T25502	6148-6152	IN	denotes	into
T25501	6138-6147	NN	denotes	migration
T25500	6132-6137	IN	denotes	after
T25499	6122-6131	VB	denotes	augmented
T25498	6117-6121	RB	denotes	even
T25497	6114-6116	VB	denotes	be
T25496	6110-6113	MD	denotes	can
T25495	6104-6109	NN	denotes	IL-10
T25494	6101-6103	TO	denotes	to
T25493	6095-6100	NN	denotes	cells
T25492	6093-6094	NN	denotes	T
T25491	6088-6092	JJ	denotes	CD4+
T25490	6085-6087	IN	denotes	of
T25489	6074-6084	NN	denotes	resistance
T25488	6070-6073	DT	denotes	the
T25487	6065-6069	IN	denotes	that
T25486	6056-6064	JJ	denotes	probable
T25485	6051-6055	RB	denotes	most
T25484	6048-6050	VB	denotes	is
T25483	6045-6047	PRP	denotes	It
T25482	6036-6043	NN	denotes	pathway
T25481	6026-6035	NN	denotes	signaling
T25480	6020-6025	NN	denotes	STAT3
T25479	6006-6019	JJ	denotes	IL-10-induced
T25478	6002-6005	DT	denotes	the
T25477	5999-6001	IN	denotes	in
T25476	5992-5998	NN	denotes	defect
T25475	5990-5991	DT	denotes	a
T25474	5983-5989	VB	denotes	showed
T25473	5978-5982	RB	denotes	also
T25472	5975-5977	NN	denotes	RA
T25471	5972-5974	IN	denotes	of
T25470	5969-5971	NN	denotes	ST
T25469	5965-5968	DT	denotes	the
T25468	5960-5964	IN	denotes	from
T25467	5951-5959	VB	denotes	isolated
T25466	5945-5950	NN	denotes	cells
T25465	5943-5944	NN	denotes	T
T25464	5938-5942	JJ	denotes	CD4+
T25463	5935-5936	-RRB-	denotes	]
T25462	5933-5935	CD	denotes	34
T25461	5932-5933	-LRB-	denotes	[
T25460	5926-5931	NN	denotes	IL-10
T25459	5923-5925	IN	denotes	of
T25458	5916-5922	NN	denotes	levels
T25457	5904-5915	JJ	denotes	significant
T25456	5894-5903	VB	denotes	producing
T25455	5891-5893	IN	denotes	of
T25454	5883-5890	JJ	denotes	capable
T25453	5879-5882	VB	denotes	are
T25452	5876-5878	NN	denotes	ST
T25451	5872-5875	DT	denotes	the
T25450	5869-5871	IN	denotes	in
T25449	5863-5868	NN	denotes	cells
T25448	5861-5862	NN	denotes	T
T25447	5856-5860	JJ	denotes	CD4+
T25446	5853-5855	NN	denotes	RA
T25445	5845-5852	IN	denotes	because
T25444	5843-5844	-COMMA-	denotes	,
T25010	3200-3202	IN	denotes	by
T25009	3193-3199	RB	denotes	mainly
T25008	3184-3192	VB	denotes	produced
T25007	3182-3183	-COMMA-	denotes	,
T25006	3177-3182	NN	denotes	IL-10
T25005	3166-3176	JJ	denotes	Endogenous
T25004	3163-3164	-RRB-	denotes	]
T25003	3161-3163	CD	denotes	10
T25002	3160-3161	-LRB-	denotes	[
T25001	3151-3159	NN	denotes	severity
T25000	3143-3150	NN	denotes	disease
T24999	3133-3142	VB	denotes	regulates
T24998	3122-3132	NN	denotes	activities
T24997	3113-3121	NN	denotes	cytokine
T24996	3104-3112	VB	denotes	opposing
T24995	3098-3103	DT	denotes	these
T24994	3090-3097	IN	denotes	between
T24993	3082-3089	NN	denotes	balance
T24992	3078-3081	DT	denotes	the
T24991	3074-3077	CC	denotes	and
T24990	3072-3073	-COMMA-	denotes	,
T24989	3070-3072	NN	denotes	RA
T24988	3067-3069	IN	denotes	of
T24987	3064-3066	NN	denotes	ST
T24986	3060-3063	DT	denotes	the
T24985	3057-3059	IN	denotes	in
T24984	3048-3056	VB	denotes	detected
T24983	3043-3047	VB	denotes	been
T24982	3038-3042	VB	denotes	have
T24981	3036-3037	-COMMA-	denotes	,
T24980	3019-3036	JJ	denotes	anti-inflammatory
T24979	3015-3018	CC	denotes	and
T24917	2625-2627	CD	denotes	II
T24916	2619-2624	NN	denotes	class
T24915	2615-2618	NN	denotes	MHC
T24914	2611-2614	CC	denotes	and
T24913	2609-2610	-COMMA-	denotes	,
T24912	2600-2609	NN	denotes	molecules
T24911	2595-2599	NN	denotes	CD86
T24910	2591-2594	CC	denotes	and
T24909	2586-2590	NN	denotes	CD80
T24908	2584-2585	-COMMA-	denotes	,
T24907	2575-2584	NN	denotes	cytokines
T24906	2572-2574	IN	denotes	of
T24905	2565-2571	NN	denotes	levels
T24904	2560-2564	JJ	denotes	high
T24903	2552-2559	VB	denotes	express
T24902	2549-2551	NN	denotes	ST
T24901	2545-2548	DT	denotes	the
T24900	2542-2544	IN	denotes	in
T24899	2530-2541	NN	denotes	macrophages
T24898	2522-2529	IN	denotes	because
T24897	2520-2521	-COMMA-	denotes	,
T24896	2518-2520	NN	denotes	RA
T24895	2515-2517	IN	denotes	in
T24894	2504-2514	NN	denotes	activation
T24893	2497-2503	NN	denotes	T-cell
T24892	2494-2496	IN	denotes	of
T24891	2489-2493	NN	denotes	site
T24890	2485-2488	DT	denotes	the
T24889	2482-2484	IN	denotes	at
T24888	2471-2481	VB	denotes	restricted
T24887	2468-2470	VB	denotes	be
T24886	2465-2467	TO	denotes	to
T24885	2457-2464	VB	denotes	thought
T24884	2454-2456	VB	denotes	is
T24883	2447-2453	NN	denotes	effect
T24882	2436-2446	JJ	denotes	inhibitory
T24881	2427-2435	JJ	denotes	indirect
T24880	2422-2426	DT	denotes	this
T24879	2420-2421	-COMMA-	denotes	,
T24878	2413-2420	RB	denotes	However
T24877	2410-2411	-RRB-	denotes	]
T24876	2409-2410	CD	denotes	1
T24875	2408-2409	-LRB-	denotes	[
T24874	2399-2407	NN	denotes	function
T24873	2394-2398	NN	denotes	cell
T24872	2375-2393	JJ	denotes	antigen-presenting
T24871	2364-2374	NN	denotes	macrophage
T24870	2361-2363	IN	denotes	of
T24869	2350-2360	NN	denotes	inhibition
T24868	2346-2349	PRP-DOLLAR-	denotes	its
T24867	2343-2345	IN	denotes	on
T24866	2333-2342	JJ	denotes	dependent
T24865	2321-2332	RB	denotes	principally
T24864	2318-2320	VB	denotes	is
T24863	2307-2317	NN	denotes	production
T24862	2298-2306	NN	denotes	cytokine
T24861	2291-2297	NN	denotes	T-cell
T24860	2286-2290	JJ	denotes	CD4+
T24859	2283-2285	IN	denotes	of
T24858	2272-2282	NN	denotes	inhibition
T24857	2257-2271	JJ	denotes	IL-10-mediated
T24856	2246-2255	NN	denotes	induction
T24855	2240-2245	NN	denotes	SOCS1
T24854	2236-2239	CC	denotes	and
T24853	2220-2235	NN	denotes	phosphorylation
T24852	2214-2219	NN	denotes	STAT3
T24851	2204-2213	JJ	denotes	sustained
T24850	2199-2203	IN	denotes	with
T24849	2187-2198	NN	denotes	association
T24848	2184-2186	IN	denotes	in
T24847	2182-2183	-COMMA-	denotes	,
T24846	2172-2182	NN	denotes	activation
T24845	2166-2171	NN	denotes	STAT3
T24844	2150-2165	JJ	denotes	IL-10-dependent
T24843	2141-2149	JJ	denotes	impaired
T24842	2138-2140	TO	denotes	to
T24841	2125-2137	JJ	denotes	attributable
T24840	2122-2124	VB	denotes	be
T24839	2118-2121	MD	denotes	may
T24838	2107-2117	NN	denotes	resistance
T24837	2102-2106	DT	denotes	this
T24836	2097-2101	IN	denotes	that
T24835	2089-2096	VB	denotes	suggest
T24834	2085-2088	CC	denotes	and
T24833	2083-2084	-COMMA-	denotes	,
T24832	2081-2083	NN	denotes	ST
T24831	2072-2080	JJ	denotes	inflamed
T24830	2068-2071	DT	denotes	the
T24829	2063-2067	IN	denotes	into
T24828	2053-2062	NN	denotes	migration
T24827	2046-2052	IN	denotes	before
T24826	2040-2045	NN	denotes	IL-10
T24825	2037-2039	IN	denotes	of
T24824	2030-2036	NN	denotes	effect
T24823	2019-2029	JJ	denotes	inhibitory
T24822	2015-2018	DT	denotes	the
T24821	2012-2014	TO	denotes	to
T24820	2002-2011	JJ	denotes	resistant
T24819	1995-2001	VB	denotes	become
T24818	1989-1994	NN	denotes	cells
T24817	1987-1988	NN	denotes	T
T24816	1982-1986	JJ	denotes	CD4+
T24815	1977-1981	IN	denotes	that
T24814	1968-1976	VB	denotes	indicate
T24813	1959-1967	NN	denotes	findings
T24812	1953-1958	DT	denotes	These
T24811	1946-1951	NN	denotes	cells
T24810	1944-1945	NN	denotes	T
T24809	1939-1943	JJ	denotes	CD4+
T24808	1932-1938	JJ	denotes	normal
T24807	1927-1931	IN	denotes	with
T24806	1916-1926	NN	denotes	comparison
T24805	1913-1915	IN	denotes	in
T24804	1901-1912	NN	denotes	transcripts
T24803	1895-1900	NN	denotes	SOCS3
T24802	1892-1894	IN	denotes	of
T24801	1885-1891	NN	denotes	levels
T24800	1879-1884	JJ	denotes	lower
T24799	1871-1878	VB	denotes	contain
T24798	1867-1870	CC	denotes	but
T24797	1861-1866	NN	denotes	SOCS1
T24796	1858-1860	IN	denotes	of
T24795	1851-1857	NN	denotes	levels
T24794	1844-1850	JJ	denotes	higher
T24793	1836-1843	VB	denotes	contain
T24792	1830-1835	NN	denotes	cells
T24791	1828-1829	NN	denotes	T
T24790	1823-1827	JJ	denotes	CD4+
T24789	1820-1822	NN	denotes	RA
T24788	1808-1818	NN	denotes	production
T24787	1802-1807	NN	denotes	IFN-γ
T24786	1799-1801	IN	denotes	of
T24785	1788-1798	NN	denotes	inhibition
T24784	1782-1787	NN	denotes	IL-10
T24783	1779-1781	TO	denotes	to
T24782	1768-1778	NN	denotes	resistance
T24781	1764-1767	DT	denotes	the
T24780	1756-1763	VB	denotes	induces
T24779	1751-1755	NN	denotes	IL-6
T24778	1741-1750	JJ	denotes	exogenous
T24777	1737-1740	CC	denotes	and
T24776	1735-1736	-COMMA-	denotes	,
T24775	1730-1735	NN	denotes	cells
T24774	1728-1729	NN	denotes	T
T24773	1723-1727	JJ	denotes	CD4+
T24772	1716-1722	JJ	denotes	normal
T24771	1713-1715	IN	denotes	in
T24770	1697-1712	NN	denotes	phosphorylation
T24769	1691-1696	NN	denotes	STAT1
T24768	1687-1690	RB	denotes	not
T24767	1683-1686	CC	denotes	but
T24766	1677-1682	NN	denotes	STAT3
T24765	1669-1676	VB	denotes	induces
T24764	1660-1668	NN	denotes	patients
T24763	1657-1659	NN	denotes	RA
T24762	1652-1656	IN	denotes	from
T24761	1647-1651	NN	denotes	IL-6
T24760	1641-1646	NN	denotes	Serum
T24759	1634-1639	NN	denotes	IL-10
T24758	1631-1633	IN	denotes	by
T24757	1621-1630	JJ	denotes	inducible
T24756	1604-1620	RB	denotes	dose-dependently
T24755	1601-1603	VB	denotes	is
T24754	1585-1600	NN	denotes	phosphorylation
T24753	1579-1584	NN	denotes	STAT3
T24752	1573-1578	WRB	denotes	where
T24751	1571-1572	-COMMA-	denotes	,
T24750	1566-1571	NN	denotes	cells
T24749	1564-1565	NN	denotes	T
T24748	1559-1563	JJ	denotes	CD4+
T24747	1552-1558	JJ	denotes	normal
T24746	1549-1551	TO	denotes	to
T24745	1540-1548	NN	denotes	contrast
T24744	1537-1539	IN	denotes	in
T24743	1535-1536	-COMMA-	denotes	,
T24742	1530-1535	NN	denotes	cells
T24741	1528-1529	NN	denotes	T
T24740	1523-1527	JJ	denotes	CD4+
T24739	1520-1522	NN	denotes	RA
T24738	1517-1519	IN	denotes	in
T24737	1506-1516	VB	denotes	suppressed
T24736	1503-1505	VB	denotes	is
T24735	1497-1502	NN	denotes	STAT3
T24734	1494-1496	IN	denotes	of
T25790	7851-7853	IN	denotes	of
T25789	7838-7850	NN	denotes	significance
T25788	7834-7837	DT	denotes	the
T25787	7832-7833	-COMMA-	denotes	,
T25786	7821-7832	RB	denotes	Furthermore
T25785	7818-7819	-RRB-	denotes	]
T25784	7816-7818	CD	denotes	38
T25783	7815-7816	-LRB-	denotes	[
T25782	7803-7814	NN	denotes	fibroblasts
T25781	7794-7802	JJ	denotes	synovial
T25780	7777-7793	JJ	denotes	factor-dependent
T25779	7770-7776	NN	denotes	growth
T25778	7767-7769	IN	denotes	of
T25777	7757-7766	NN	denotes	expansion
T25776	7753-7756	CC	denotes	and
T25775	7744-7752	NN	denotes	survival
T25774	7740-7743	DT	denotes	the
T25773	7737-7739	IN	denotes	in
T25772	7728-7736	JJ	denotes	critical
T25771	7725-7727	VB	denotes	is
T25770	7719-7724	NN	denotes	STAT3
T25769	7717-7718	-COMMA-	denotes	,
T25768	7711-7717	NN	denotes	regard
T25767	7706-7710	DT	denotes	this
T25766	7703-7705	IN	denotes	In
T25765	7700-7701	-RRB-	denotes	]
T25764	7698-7700	CD	denotes	37
T25763	7697-7698	-LRB-	denotes	[
T25762	7686-7696	NN	denotes	production
T25761	7681-7685	NN	denotes	IL-6
T25760	7677-7680	CC	denotes	and
T25759	7663-7676	NN	denotes	proliferation
T25758	7652-7662	NN	denotes	fibroblast
T25757	7643-7651	JJ	denotes	synovial
T25756	7640-7642	IN	denotes	in
T25755	7631-7639	VB	denotes	involved
T25754	7628-7630	VB	denotes	be
T25753	7625-7627	TO	denotes	to
T25752	7619-7624	VB	denotes	shown
T25751	7614-7618	VB	denotes	been
T25750	7610-7613	VB	denotes	has
T25749	7599-7609	NN	denotes	activation
T25748	7593-7598	NN	denotes	STAT3
T25747	7589-7592	CC	denotes	and
T25746	7587-7588	-COMMA-	denotes	,
T25745	7585-7587	NN	denotes	ST
T25744	7581-7584	DT	denotes	the
T25743	7578-7580	IN	denotes	in
T25742	7569-7577	VB	denotes	detected
T25741	7564-7568	VB	denotes	been
T25740	7559-7563	VB	denotes	have
T25739	7557-7558	-COMMA-	denotes	,
T25738	7553-7557	NN	denotes	IL-6
T25737	7550-7552	IN	denotes	by
T25736	7543-7549	RB	denotes	mainly
T25735	7535-7542	VB	denotes	induced
T25734	7532-7534	VB	denotes	be
T25733	7529-7531	TO	denotes	to
T25732	7521-7528	VB	denotes	thought
T25731	7519-7520	-COMMA-	denotes	,
T25730	7514-7519	NN	denotes	STAT3
T25729	7504-7513	VB	denotes	activated
T25728	7501-7503	IN	denotes	of
T25727	7494-7500	NN	denotes	levels
T25726	7489-7493	JJ	denotes	high
T25725	7487-7488	-COMMA-	denotes	,
T25724	7479-7487	RB	denotes	recently
T25723	7474-7478	RB	denotes	More
T25722	7471-7472	-RRB-	denotes	]
T25721	7469-7471	CD	denotes	31
T25720	7468-7469	-LRB-	denotes	[
T25719	7461-7467	NN	denotes	HLA-DR
T25718	7458-7460	IN	denotes	of
T25717	7454-7457	CC	denotes	and
T25716	7450-7453	CD	denotes	III
T25715	7445-7449	NN	denotes	type
T25714	7441-7444	CC	denotes	and
T25713	7439-7440	CD	denotes	I
T25712	7434-7438	NN	denotes	type
T25711	7425-7433	NN	denotes	receptor
T25710	7419-7424	NN	denotes	gamma
T25709	7416-7418	NN	denotes	Fc
T25708	7412-7415	DT	denotes	the
T25707	7409-7411	IN	denotes	of
T25706	7398-7408	NN	denotes	expression
T25705	7393-7397	NN	denotes	gene
T25704	7390-7392	IN	denotes	as
T25703	7385-7389	JJ	denotes	such
T25702	7375-7384	NN	denotes	functions
T25701	7366-7374	NN	denotes	monocyte
T25700	7363-7365	IN	denotes	of
T25699	7352-7362	NN	denotes	activation
T25698	7348-7351	DT	denotes	the
T25697	7345-7347	IN	denotes	in
T25696	7340-7344	NN	denotes	role
T25695	7332-7339	JJ	denotes	crucial
T25694	7330-7331	DT	denotes	a
T25693	7326-7329	VB	denotes	has
T25692	7320-7325	WDT	denotes	which
T25691	7318-7319	-COMMA-	denotes	,
T25690	7313-7318	NN	denotes	fluid
T25689	7304-7312	JJ	denotes	synovial
T25688	7301-7303	IN	denotes	in
T25687	7293-7300	JJ	denotes	present
T25686	7286-7292	NN	denotes	factor
T25685	7269-7285	JJ	denotes	STAT3-activating
T25684	7263-7268	JJ	denotes	major
T25683	7259-7262	DT	denotes	the
T25682	7256-7258	VB	denotes	is
T25681	7251-7255	NN	denotes	IL-6
T25680	7248-7249	-RRB-	denotes	]
T25679	7246-7248	CD	denotes	36
T25678	7245-7246	-LRB-	denotes	[
T25677	7236-7244	NN	denotes	patients
T25676	7233-7235	NN	denotes	RA
T25675	7228-7232	IN	denotes	from
T25674	7222-7227	NN	denotes	cells
T25673	7210-7221	JJ	denotes	mononuclear
T25672	7204-7209	NN	denotes	fluid
T25671	7195-7203	JJ	denotes	synovial
T25670	7192-7194	IN	denotes	in
T25669	7182-7191	VB	denotes	expressed
T25668	7167-7181	RB	denotes	constitutively
T25667	7164-7166	VB	denotes	is
T25666	7158-7163	NN	denotes	STAT3
T25665	7151-7157	JJ	denotes	Active
T25664	7147-7149	NN	denotes	RA
T25663	7144-7146	IN	denotes	of
T25662	7131-7143	NN	denotes	pathogenesis
T25661	7127-7130	DT	denotes	the
T25660	7124-7126	IN	denotes	in
T25659	7113-7123	VB	denotes	implicated
T25658	7108-7112	VB	denotes	been
T25657	7104-7107	VB	denotes	has
T25656	7093-7103	NN	denotes	activation
T25655	7087-7092	NN	denotes	STAT3
T25654	7084-7085	-RRB-	denotes	]
T25653	7082-7084	CD	denotes	10
T25652	7081-7082	-LRB-	denotes	[
T25651	7067-7080	RB	denotes	substantially
T25650	7059-7066	JJ	denotes	present
T25649	7055-7058	VB	denotes	are
T25648	7045-7054	NN	denotes	cytokines
T25647	7040-7044	JJ	denotes	many
T25646	7034-7039	WRB	denotes	where
T25645	7032-7033	-COMMA-	denotes	,
T25644	7026-7032	NN	denotes	joints
T25643	7023-7025	NN	denotes	RA
T25642	7020-7022	IN	denotes	in
T25641	7008-7019	NN	denotes	environment
T25640	6995-7007	JJ	denotes	inflammatory
T25639	6992-6994	DT	denotes	an
T25638	6989-6991	TO	denotes	to
T25637	6980-6988	NN	denotes	exposure
T25636	6975-6979	IN	denotes	upon
T25635	6961-6974	RB	denotes	complicatedly
T25634	6951-6960	VB	denotes	modulated
T25227	4639-4641	NN	denotes	RA
T25226	4636-4638	IN	denotes	in
T25225	4624-4635	NN	denotes	environment
T25224	4611-4623	JJ	denotes	inflammatory
T25223	4607-4610	DT	denotes	the
T25222	4601-4606	IN	denotes	under
T25221	4595-4600	NN	denotes	level
T25220	4582-4594	NN	denotes	transduction
T25219	4575-4581	NN	denotes	signal
T25218	4571-4574	DT	denotes	the
T25217	4568-4570	IN	denotes	at
T25216	4558-4567	VB	denotes	modulated
T25215	4543-4557	RB	denotes	differentially
T25214	4533-4542	RB	denotes	therefore
T25213	4529-4532	VB	denotes	are
T25212	4523-4528	NN	denotes	types
T25211	4518-4522	NN	denotes	cell
T25210	4505-4517	JJ	denotes	inflammatory
T25209	4499-4504	DT	denotes	these
T25208	4496-4498	IN	denotes	on
T25207	4490-4495	NN	denotes	IL-10
T25206	4487-4489	IN	denotes	of
T25205	4479-4486	NN	denotes	effects
T25204	4468-4478	JJ	denotes	Inhibitory
T25203	4456-4466	NN	denotes	expression
T25202	4448-4455	NN	denotes	IL-10R1
T25201	4443-4447	IN	denotes	with
T25200	4439-4442	RB	denotes	not
T25199	4435-4438	CC	denotes	but
T25198	4433-4434	-COMMA-	denotes	,
T25197	4423-4433	NN	denotes	activation
T25196	4417-4422	NN	denotes	STAT3
T25195	4401-4416	JJ	denotes	IL-10-dependent
T24733	1478-1493	NN	denotes	phosphorylation
T24732	1469-1477	NN	denotes	tyrosine
T24731	1455-1468	JJ	denotes	IL-10-induced
T24730	1453-1454	-COMMA-	denotes	,
T24729	1443-1453	NN	denotes	activation
T24728	1437-1442	NN	denotes	STAT3
T24727	1424-1436	JJ	denotes	constitutive
T24726	1420-1423	CC	denotes	and
T24725	1409-1419	NN	denotes	expression
T24724	1401-1408	NN	denotes	IL-10R1
T24723	1390-1400	JJ	denotes	high-level
T24722	1382-1389	IN	denotes	Despite
T24721	1375-1380	NN	denotes	cells
T24720	1373-1374	NN	denotes	T
T24719	1368-1372	JJ	denotes	CD4+
T24718	1361-1367	JJ	denotes	normal
T24717	1356-1360	IN	denotes	than
T24716	1342-1355	NN	denotes	costimulation
T24715	1337-1341	NN	denotes	CD28
T24714	1333-1336	CC	denotes	and
T24713	1329-1332	NN	denotes	CD3
T24712	1323-1328	IN	denotes	after
T24711	1317-1322	NN	denotes	IFN-γ
T24710	1314-1316	IN	denotes	of
T24709	1307-1313	NN	denotes	levels
T24708	1300-1306	JJ	denotes	higher
T24707	1292-1299	VB	denotes	produce
T24706	1289-1291	TO	denotes	to
T24705	1284-1288	JJ	denotes	able
T24704	1280-1283	VB	denotes	are
T24703	1278-1279	-COMMA-	denotes	,
T24702	1273-1278	NN	denotes	IL-10
T24670	1129-1132	CC	denotes	and
T24669	1127-1128	-COMMA-	denotes	,
T24668	1122-1127	NN	denotes	cells
T24667	1120-1121	NN	denotes	T
T24666	1117-1119	IN	denotes	in
T24665	1109-1116	NN	denotes	binding
T24664	1100-1108	NN	denotes	3-kinase
T24663	1079-1099	NN	denotes	phosphatidylinositol
T24662	1068-1078	JJ	denotes	subsequent
T24661	1064-1067	DT	denotes	the
T24660	1060-1063	CC	denotes	and
T24659	1051-1059	NN	denotes	molecule
T24658	1046-1050	NN	denotes	CD28
T24657	1042-1045	DT	denotes	the
T24656	1039-1041	IN	denotes	of
T24655	1023-1038	NN	denotes	phosphorylation
T24654	1014-1022	NN	denotes	tyrosine
T24653	1010-1013	DT	denotes	the
T24652	1001-1009	VB	denotes	inhibits
T24651	995-1000	NN	denotes	IL-10
T24650	992-993	-RRB-	denotes	]
T24649	991-992	CD	denotes	1
T24648	990-991	-LRB-	denotes	[
T24647	984-989	NN	denotes	cells
T24646	980-983	NN	denotes	Th1
T24645	976-979	CC	denotes	and
T24644	964-975	NN	denotes	macrophages
T24643	959-963	CC	denotes	both
T24642	956-958	IN	denotes	of
T24641	947-955	NN	denotes	function
T24640	943-946	DT	denotes	the
T24639	932-942	VB	denotes	regulating
T24638	929-931	IN	denotes	by
T24637	919-928	NN	denotes	responses
T24636	906-918	JJ	denotes	inflammatory
T24635	902-905	CC	denotes	and
T24634	895-901	JJ	denotes	immune
T24633	886-894	VB	denotes	limiting
T24632	883-885	IN	denotes	in
T24631	878-882	NN	denotes	role
T24630	866-877	JJ	denotes	predominant
T24629	864-865	DT	denotes	a
T24628	858-863	VB	denotes	plays
T24627	852-857	NN	denotes	IL-10
T24626	849-850	-RRB-	denotes	]
T24625	847-849	CD	denotes	23
T24624	846-847	-LRB-	denotes	[
T24623	837-845	NN	denotes	patients
T24622	834-836	NN	denotes	RA
T24621	831-833	IN	denotes	in
T24620	826-830	NN	denotes	-IgG
T24619	825-826	-RRB-	denotes	)
T24618	820-825	NN	denotes	CD152
T24617	819-820	-LRB-	denotes	(
T24616	817-818	CD	denotes	4
T24615	809-816	NN	denotes	antigen
T24614	791-808	JJ	denotes	T-cell-associated
T24613	781-790	JJ	denotes	cytotoxic
T24612	773-780	NN	denotes	blocker
T24611	769-772	PRP-DOLLAR-	denotes	its
T24610	766-768	IN	denotes	of
T24609	757-765	NN	denotes	efficacy
T24608	748-756	JJ	denotes	clinical
T24607	744-747	DT	denotes	the
T24606	741-743	IN	denotes	by
T24605	734-740	VB	denotes	proven
T24604	729-733	VB	denotes	been
T24603	720-728	RB	denotes	recently
T24602	716-719	VB	denotes	has
T24601	708-715	NN	denotes	process
T24600	700-707	NN	denotes	disease
T24599	684-699	JJ	denotes	T-cell-mediated
T24598	680-683	DT	denotes	the
T24597	677-679	IN	denotes	in
T24596	666-676	NN	denotes	engagement
T24595	661-665	NN	denotes	CD28
T24594	658-660	IN	denotes	of
T24593	645-657	NN	denotes	significance
T24592	641-644	DT	denotes	The
T24591	638-639	-RRB-	denotes	]
T24590	633-638	CD	denotes	18-20
T24589	632-633	-LRB-	denotes	[
T24588	626-631	NN	denotes	cells
T24587	616-625	JJ	denotes	dendritic
T24586	612-615	CC	denotes	and
T24585	600-611	NN	denotes	macrophages
T24584	597-599	IN	denotes	as
T24583	592-596	JJ	denotes	such
T24582	586-591	NN	denotes	cells
T24581	567-585	JJ	denotes	antigen-presenting
T24580	564-566	IN	denotes	by
T24579	554-563	VB	denotes	expressed
T24578	540-553	RB	denotes	substantially
T24577	536-539	VB	denotes	are
T24576	534-535	-COMMA-	denotes	,
T24575	526-534	NN	denotes	antigens
T24574	523-525	CD	denotes	II
T24573	517-522	NN	denotes	class
T24572	513-516	NN	denotes	MHC
T24571	508-512	IN	denotes	with
T24570	499-507	RB	denotes	together
T24569	497-498	-COMMA-	denotes	,
T24568	493-497	NN	denotes	CD86
T24567	489-492	CC	denotes	and
T24566	484-488	NN	denotes	CD80
T24565	479-483	CC	denotes	both
T24564	477-478	-COMMA-	denotes	,
T24563	470-477	NN	denotes	ligands
T24562	465-469	NN	denotes	CD28
T24561	461-464	DT	denotes	the
T24560	459-460	-COMMA-	denotes	,
T24559	453-459	NN	denotes	lesion
T24558	450-452	NN	denotes	ST
T24557	446-449	DT	denotes	the
T24556	443-445	IN	denotes	In
T24555	428-441	NN	denotes	costimulation
T24554	414-427	JJ	denotes	CD28-mediated
T24553	410-413	CC	denotes	and
T24552	400-409	NN	denotes	occupancy
T24551	391-399	NN	denotes	receptor
T24550	383-390	NN	denotes	antigen
T24549	381-382	-COLON-	denotes	;
T24548	372-381	VB	denotes	activated
T24547	369-371	VB	denotes	be
T24546	366-368	TO	denotes	to
T24545	358-365	NN	denotes	signals
T24544	354-357	CD	denotes	two
T24543	346-353	VB	denotes	require
T24542	340-345	NN	denotes	cells
T24541	338-339	NN	denotes	T
T24540	333-337	JJ	denotes	CD4+
T24539	320-331	NN	denotes	destruction
T24538	314-319	JJ	denotes	joint
T24537	310-313	DT	denotes	the
T24536	306-309	CC	denotes	and
T24535	293-305	NN	denotes	inflammation
T24534	285-292	JJ	denotes	chronic
T24533	281-284	DT	denotes	the
T24532	276-280	CC	denotes	both
T24531	273-275	TO	denotes	to
T24530	260-272	VB	denotes	contributing
T24529	252-259	RB	denotes	thereby
T24528	250-251	-COMMA-	denotes	,
T24527	241-250	NN	denotes	cytokines
T24526	237-240	NN	denotes	Th1
T24525	233-236	CC	denotes	and
T24524	223-232	NN	denotes	molecules
T24523	215-222	NN	denotes	surface
T24522	210-214	NN	denotes	cell
T24521	207-209	IN	denotes	of
T24520	196-206	NN	denotes	expression
T24519	192-195	DT	denotes	the
T24518	184-191	IN	denotes	through
T24517	172-183	VB	denotes	osteoclasts
T24516	168-171	CC	denotes	and
T24515	166-167	-COMMA-	denotes	,
T24514	161-166	NN	denotes	cells
T24513	159-160	NN	denotes	B
T24512	157-158	-COMMA-	denotes	,
T24511	146-157	NN	denotes	fibroblasts
T24510	137-145	JJ	denotes	synovial
T24509	135-136	-COMMA-	denotes	,
T24508	124-135	NN	denotes	macrophages
T24507	114-123	VB	denotes	stimulate
T24506	108-113	NN	denotes	cells
T24505	106-107	NN	denotes	T
T24504	101-105	JJ	denotes	CD4+
T24503	91-100	VB	denotes	Activated
T24502	88-89	-RRB-	denotes	]
T24501	86-88	CD	denotes	22
T24500	85-86	-LRB-	denotes	[
T24499	82-84	NN	denotes	RA
T24498	79-81	IN	denotes	in
T24497	70-78	NN	denotes	response
T24496	63-69	JJ	denotes	immune
T24495	49-62	JJ	denotes	cell-mediated
T24494	40-48	JJ	denotes	Th1-type
T24493	36-39	DT	denotes	the
T24492	24-35	VB	denotes	orchestrate
T24491	18-23	NN	denotes	cells
T24490	16-17	NN	denotes	T
T24489	11-15	JJ	denotes	CD4+
T25794	7881-7883	IN	denotes	in
T25793	7871-7880	NN	denotes	signaling
T25792	7865-7870	NN	denotes	STAT3
T25791	7854-7864	JJ	denotes	persistent
T24978	2999-3014	JJ	denotes	proinflammatory
T24977	2994-2998	CC	denotes	both
T24976	2992-2993	-COMMA-	denotes	,
T24975	2983-2992	NN	denotes	cytokines
T24974	2974-2982	JJ	denotes	Numerous
T24973	2968-2972	NN	denotes	IL-2
T24972	2964-2967	CC	denotes	and
T24971	2958-2963	NN	denotes	IFN-γ
T24970	2953-2957	CC	denotes	both
T24969	2950-2952	IN	denotes	of
T24968	2939-2949	NN	denotes	production
T24967	2921-2938	JJ	denotes	CD28-costimulated
T24966	2918-2920	IN	denotes	of
T24965	2907-2917	NN	denotes	inhibition
T24964	2901-2906	NN	denotes	IL-10
T24963	2891-2900	JJ	denotes	defective
T24962	2889-2890	DT	denotes	a
T24961	2882-2888	VB	denotes	showed
T24960	2876-2881	NN	denotes	cells
T24959	2874-2875	NN	denotes	T
T24958	2869-2873	JJ	denotes	CD4+
T24957	2866-2868	NN	denotes	PB
T24956	2860-2865	PRP-DOLLAR-	denotes	their
T24955	2852-2859	IN	denotes	because
T24954	2850-2851	-COMMA-	denotes	,
T24953	2842-2850	NN	denotes	patients
T24952	2839-2841	NN	denotes	RA
T24951	2832-2838	JJ	denotes	active
T24950	2829-2831	IN	denotes	in
T24949	2821-2828	VB	denotes	limited
T24948	2818-2820	VB	denotes	be
T24947	2814-2817	MD	denotes	may
T24946	2809-2813	RB	denotes	also
T24945	2802-2808	NN	denotes	effect
T24944	2795-2801	JJ	denotes	direct
T24943	2790-2794	DT	denotes	This
T24942	2787-2788	-RRB-	denotes	]
T24941	2785-2787	CD	denotes	33
T24940	2784-2785	-LRB-	denotes	[
T24939	2768-2783	NN	denotes	phosphorylation
T24938	2759-2767	NN	denotes	tyrosine
T24937	2754-2758	NN	denotes	CD28
T24936	2743-2753	VB	denotes	inhibiting
T24935	2740-2742	IN	denotes	by
T24934	2723-2739	NN	denotes	unresponsiveness
T24933	2716-2722	NN	denotes	T-cell
T24932	2699-2715	JJ	denotes	antigen-specific
T24931	2695-2698	DT	denotes	the
T24930	2688-2694	VB	denotes	induce
T24929	2685-2687	TO	denotes	to
T24928	2679-2684	VB	denotes	shown
T24927	2674-2678	VB	denotes	been
T24926	2670-2673	VB	denotes	has
T24925	2664-2669	NN	denotes	IL-10
T24924	2662-2663	-COMMA-	denotes	,
T24923	2654-2662	RB	denotes	recently
T24922	2649-2653	RB	denotes	More
T24921	2646-2647	-RRB-	denotes	]
T24920	2638-2646	CD	denotes	10,18-20
T24919	2637-2638	-LRB-	denotes	[
T24918	2628-2636	NN	denotes	antigens
T24701	1270-1272	IN	denotes	of
T24700	1261-1269	NN	denotes	presence
T24699	1257-1260	DT	denotes	the
T24698	1254-1256	IN	denotes	in
T24697	1252-1253	-COMMA-	denotes	,
T24696	1250-1252	NN	denotes	RA
T24695	1243-1249	JJ	denotes	active
T24694	1238-1242	IN	denotes	with
T24693	1229-1237	NN	denotes	patients
T24692	1224-1228	IN	denotes	from
T24691	1218-1223	NN	denotes	cells
T24690	1216-1217	NN	denotes	T
T24689	1211-1215	JJ	denotes	CD4+
T24688	1208-1210	NN	denotes	PB
T24687	1203-1207	IN	denotes	that
T24686	1197-1202	VB	denotes	found
T24685	1194-1196	PRP	denotes	we
T24684	1192-1193	-COMMA-	denotes	,
T24683	1187-1192	NN	denotes	study
T24682	1179-1186	JJ	denotes	present
T24681	1175-1178	DT	denotes	the
T24680	1172-1174	IN	denotes	In
T24679	1169-1170	-RRB-	denotes	]
T24678	1167-1169	CD	denotes	24
T24677	1166-1167	-LRB-	denotes	[
T24676	1160-1165	NN	denotes	cells
T24675	1158-1159	NN	denotes	T
T24674	1155-1157	IN	denotes	on
T24673	1150-1154	VB	denotes	acts
T24672	1141-1149	RB	denotes	directly
T24671	1133-1140	RB	denotes	thereby
R11542	T24491	T24489	arg1Of	cells,CD4+
R11543	T24491	T24490	arg1Of	cells,T
R11544	T24491	T24492	arg1Of	cells,orchestrate
R11545	T24497	T24492	arg2Of	response,orchestrate
R11546	T24497	T24493	arg1Of	response,the
R11547	T24497	T24494	arg1Of	response,Th1-type
R11548	T24497	T24495	arg1Of	response,cell-mediated
R11549	T24497	T24496	arg1Of	response,immune
R11550	T24497	T24498	arg1Of	response,in
R11551	T24499	T24498	arg2Of	RA,in
R11552	T24499	T24500	arg1Of	RA,[
R11553	T24501	T24500	arg2Of	22,[
R11554	T24502	T24500	arg3Of	],[
R11555	T24506	T24503	arg2Of	cells,Activated
R11556	T24506	T24504	arg1Of	cells,CD4+
R11557	T24506	T24505	arg1Of	cells,T
R11558	T24506	T24507	arg1Of	cells,stimulate
R11559	T24506	T24517	arg1Of	cells,osteoclasts
R11560	T24506	T24530	arg1Of	cells,contributing
R11561	T24507	T24516	arg1Of	stimulate,and
R11562	T24508	T24509	arg1Of	macrophages,","
R11563	T24509	T24512	arg1Of	",",","
R11564	T24511	T24509	arg2Of	fibroblasts,","
R11565	T24511	T24510	arg1Of	fibroblasts,synovial
R11566	T24512	T24507	arg2Of	",",stimulate
R11567	T24514	T24512	arg2Of	cells,","
R11568	T24514	T24513	arg1Of	cells,B
R11569	T24516	T24515	arg1Of	and,","
R11570	T24517	T24516	arg2Of	osteoclasts,and
R11571	T24517	T24518	arg1Of	osteoclasts,through
R11572	T24517	T24528	arg1Of	osteoclasts,","
R11573	T24520	T24518	arg2Of	expression,through
R11574	T24520	T24519	arg1Of	expression,the
R11575	T24520	T24521	arg1Of	expression,of
R11576	T24524	T24522	arg1Of	molecules,cell
R11577	T24524	T24523	arg1Of	molecules,surface
R11578	T24524	T24525	arg1Of	molecules,and
R11579	T24525	T24521	arg2Of	and,of
R11580	T24527	T24525	arg2Of	cytokines,and
R11581	T24527	T24526	arg1Of	cytokines,Th1
R11582	T24530	T24517	arg2Of	contributing,osteoclasts
R11583	T24530	T24529	arg1Of	contributing,thereby
R11584	T24530	T24531	arg1Of	contributing,to
R11585	T24535	T24533	arg1Of	inflammation,the
R11586	T24535	T24534	arg1Of	inflammation,chronic
R11587	T24535	T24536	arg1Of	inflammation,and
R11588	T24536	T24531	arg2Of	and,to
R11589	T24536	T24532	arg1Of	and,both
R11590	T24539	T24536	arg2Of	destruction,and
R11591	T24539	T24537	arg1Of	destruction,the
R11592	T24539	T24538	arg1Of	destruction,joint
R11593	T24542	T24540	arg1Of	cells,CD4+
R11594	T24542	T24541	arg1Of	cells,T
R11595	T24542	T24543	arg1Of	cells,require
R11596	T24545	T24543	arg2Of	signals,require
R11597	T24545	T24544	arg1Of	signals,two
R11598	T24545	T24547	arg1Of	signals,be
R11599	T24545	T24548	arg2Of	signals,activated
R11600	T24548	T24543	arg3Of	activated,require
R11601	T24548	T24546	arg1Of	activated,to
R11602	T24548	T24547	arg2Of	activated,be
R11603	T24548	T24549	arg1Of	activated,;
R11604	T24552	T24550	arg1Of	occupancy,antigen
R11605	T24552	T24551	arg1Of	occupancy,receptor
R11606	T24552	T24553	arg1Of	occupancy,and
R11607	T24553	T24548	arg3Of	and,activated
R11608	T24555	T24553	arg2Of	costimulation,and
R11609	T24555	T24554	arg1Of	costimulation,CD28-mediated
R11610	T24559	T24556	arg2Of	lesion,In
R11611	T24559	T24557	arg1Of	lesion,the
R11612	T24559	T24558	arg1Of	lesion,ST
R11613	T24563	T24561	arg1Of	ligands,the
R11614	T24563	T24562	arg1Of	ligands,CD28
R11615	T24563	T24564	arg1Of	ligands,","
R11616	T24563	T24577	arg1Of	ligands,are
R11617	T24563	T24579	arg2Of	ligands,expressed
R11618	T24566	T24567	arg1Of	CD80,and
R11619	T24567	T24564	arg2Of	and,","
R11620	T24567	T24565	arg1Of	and,both
R11621	T24568	T24567	arg2Of	CD86,and
R11622	T24570	T24571	arg1Of	together,with
R11623	T24575	T24571	arg2Of	antigens,with
R11624	T24575	T24572	arg1Of	antigens,MHC
R11625	T24575	T24573	arg1Of	antigens,class
R11626	T24575	T24574	arg1Of	antigens,II
R11627	T24579	T24556	arg1Of	expressed,In
R11628	T24579	T24560	arg1Of	expressed,","
R11629	T24579	T24569	arg1Of	expressed,","
R11630	T24579	T24570	arg1Of	expressed,together
R11631	T24579	T24576	arg1Of	expressed,","
R11632	T24579	T24577	arg2Of	expressed,are
R11633	T24579	T24578	arg1Of	expressed,substantially
R11634	T24582	T24579	arg1Of	cells,expressed
R11635	T24582	T24580	arg2Of	cells,by
R11636	T24582	T24581	arg1Of	cells,antigen-presenting
R11637	T24582	T24584	arg1Of	cells,as
R11638	T24584	T24583	arg1Of	as,such
R11639	T24585	T24586	arg1Of	macrophages,and
R11640	T24586	T24584	arg2Of	and,as
R11641	T24588	T24586	arg2Of	cells,and
R11642	T24588	T24587	arg1Of	cells,dendritic
R11643	T24588	T24589	arg1Of	cells,[
R11644	T24590	T24589	arg2Of	18-20,[
R11645	T24591	T24589	arg3Of	],[
R11646	T24593	T24592	arg1Of	significance,The
R11647	T24593	T24594	arg1Of	significance,of
R11648	T24593	T24597	arg1Of	significance,in
R11649	T24593	T24602	arg1Of	significance,has
R11650	T24593	T24604	arg1Of	significance,been
R11651	T24593	T24605	arg2Of	significance,proven
R11652	T24596	T24594	arg2Of	engagement,of
R11653	T24596	T24595	arg1Of	engagement,CD28
R11654	T24601	T24597	arg2Of	process,in
R11655	T24601	T24598	arg1Of	process,the
R11656	T24601	T24599	arg1Of	process,T-cell-mediated
R11657	T24601	T24600	arg1Of	process,disease
R11658	T24605	T24602	arg2Of	proven,has
R11659	T24605	T24603	arg1Of	proven,recently
R11660	T24605	T24604	arg2Of	proven,been
R11661	T24609	T24605	arg1Of	efficacy,proven
R11662	T24609	T24606	arg2Of	efficacy,by
R11663	T24609	T24607	arg1Of	efficacy,the
R11664	T24609	T24608	arg1Of	efficacy,clinical
R11665	T24609	T24610	arg1Of	efficacy,of
R11666	T24609	T24621	arg1Of	efficacy,in
R11667	T24614	T24612	arg1Of	T-cell-associated,blocker
R11668	T24614	T24613	arg1Of	T-cell-associated,cytotoxic
R11669	T24618	T24617	arg2Of	CD152,(
R11670	T24619	T24617	arg3Of	),(
R11671	T24620	T24610	arg2Of	-IgG,of
R11672	T24620	T24611	arg1Of	-IgG,its
R11673	T24620	T24614	arg1Of	-IgG,T-cell-associated
R11674	T24620	T24615	arg1Of	-IgG,antigen
R11675	T24620	T24616	arg1Of	-IgG,4
R11676	T24620	T24617	arg1Of	-IgG,(
R11677	T24623	T24621	arg2Of	patients,in
R11678	T24623	T24622	arg1Of	patients,RA
R11679	T24623	T24624	arg1Of	patients,[
R11680	T24625	T24624	arg2Of	23,[
R11681	T24626	T24624	arg3Of	],[
R11682	T24627	T24628	arg1Of	IL-10,plays
R11683	T24627	T24633	arg1Of	IL-10,limiting
R11684	T24627	T24639	arg1Of	IL-10,regulating
R11685	T24628	T24632	arg1Of	plays,in
R11686	T24631	T24628	arg2Of	role,plays
R11687	T24631	T24629	arg1Of	role,a
R11688	T24631	T24630	arg1Of	role,predominant
R11689	T24633	T24632	arg2Of	limiting,in
R11690	T24633	T24638	arg1Of	limiting,by
R11691	T24634	T24635	arg1Of	immune,and
R11692	T24636	T24635	arg2Of	inflammatory,and
R11693	T24637	T24633	arg2Of	responses,limiting
R11694	T24637	T24634	arg1Of	responses,immune
R11695	T24637	T24636	arg1Of	responses,inflammatory
R11696	T24639	T24638	arg2Of	regulating,by
R11697	T24641	T24639	arg2Of	function,regulating
R11698	T24641	T24640	arg1Of	function,the
R11699	T24641	T24642	arg1Of	function,of
R11700	T24644	T24645	arg1Of	macrophages,and
R11701	T24645	T24642	arg2Of	and,of
R11702	T24645	T24643	arg1Of	and,both
R11703	T24645	T24648	arg1Of	and,[
R11704	T24647	T24645	arg2Of	cells,and
R11705	T24647	T24646	arg1Of	cells,Th1
R11706	T24649	T24648	arg2Of	1,[
R11707	T24650	T24648	arg3Of	],[
R11708	T24651	T24652	arg1Of	IL-10,inhibits
R11709	T24651	T24673	arg1Of	IL-10,acts
R11710	T24652	T24670	arg1Of	inhibits,and
R11711	T24655	T24653	arg1Of	phosphorylation,the
R11712	T24655	T24654	arg1Of	phosphorylation,tyrosine
R11713	T24655	T24656	arg1Of	phosphorylation,of
R11714	T24655	T24660	arg1Of	phosphorylation,and
R11715	T24659	T24656	arg2Of	molecule,of
R11716	T24659	T24657	arg1Of	molecule,the
R11717	T24659	T24658	arg1Of	molecule,CD28
R11718	T24660	T24652	arg2Of	and,inhibits
R11719	T24665	T24660	arg2Of	binding,and
R11720	T24665	T24661	arg1Of	binding,the
R11721	T24665	T24662	arg1Of	binding,subsequent
R11722	T24665	T24663	arg1Of	binding,phosphatidylinositol
R11723	T24665	T24664	arg1Of	binding,3-kinase
R11724	T24665	T24666	arg1Of	binding,in
R11725	T24668	T24666	arg2Of	cells,in
R11726	T24668	T24667	arg1Of	cells,T
R11727	T24670	T24669	arg1Of	and,","
R11728	T24673	T24670	arg2Of	acts,and
R11729	T24673	T24671	arg1Of	acts,thereby
R11730	T24673	T24672	arg1Of	acts,directly
R11731	T24673	T24674	arg1Of	acts,on
R11732	T24673	T24677	arg1Of	acts,[
R11733	T24676	T24674	arg2Of	cells,on
R11734	T24676	T24675	arg1Of	cells,T
R11735	T24678	T24677	arg2Of	24,[
R11736	T24679	T24677	arg3Of	],[
R11737	T24683	T24680	arg2Of	study,In
R11738	T24683	T24681	arg1Of	study,the
R11739	T24683	T24682	arg1Of	study,present
R11740	T24685	T24686	arg1Of	we,found
R11741	T24686	T24680	arg1Of	found,In
R11742	T24686	T24684	arg1Of	found,","
R11743	T24691	T24688	arg1Of	cells,PB
R11744	T24691	T24689	arg1Of	cells,CD4+
R11745	T24691	T24690	arg1Of	cells,T
R11746	T24691	T24692	arg1Of	cells,from
R11747	T24691	T24704	arg1Of	cells,are
R11748	T24691	T24705	arg1Of	cells,able
R11749	T24691	T24707	arg1Of	cells,produce
R11750	T24693	T24692	arg2Of	patients,from
R11751	T24693	T24694	arg1Of	patients,with
R11752	T24696	T24694	arg2Of	RA,with
R11753	T24696	T24695	arg1Of	RA,active
R11754	T24700	T24698	arg2Of	presence,in
R11755	T24700	T24699	arg1Of	presence,the
R11756	T24700	T24701	arg1Of	presence,of
R11757	T24702	T24701	arg2Of	IL-10,of
R11758	T24704	T24686	arg2Of	are,found
R11759	T24704	T24687	arg1Of	are,that
R11760	T24704	T24697	arg1Of	are,","
R11761	T24704	T24698	arg1Of	are,in
R11762	T24704	T24703	arg1Of	are,","
R11763	T24705	T24704	arg2Of	able,are
R11764	T24707	T24705	arg2Of	produce,able
R11765	T24707	T24706	arg1Of	produce,to
R11766	T24709	T24707	arg2Of	levels,produce
R11767	T24709	T24708	arg1Of	levels,higher
R11768	T24709	T24710	arg1Of	levels,of
R11769	T24711	T24710	arg2Of	IFN-γ,of
R11770	T24711	T24712	arg1Of	IFN-γ,after
R11771	T24711	T24717	arg1Of	IFN-γ,than
R11772	T24713	T24714	arg1Of	CD3,and
R11773	T24715	T24714	arg2Of	CD28,and
R11774	T24716	T24712	arg2Of	costimulation,after
R11775	T24716	T24713	arg1Of	costimulation,CD3
R11776	T24716	T24715	arg1Of	costimulation,CD28
R11777	T24721	T24717	arg2Of	cells,than
R11778	T24721	T24718	arg1Of	cells,normal
R11779	T24721	T24719	arg1Of	cells,CD4+
R11780	T24721	T24720	arg1Of	cells,T
R11781	T24725	T24723	arg1Of	expression,high-level
R11782	T24725	T24724	arg1Of	expression,IL-10R1
R11783	T24725	T24726	arg1Of	expression,and
R11784	T24726	T24722	arg2Of	and,Despite
R11785	T24729	T24726	arg2Of	activation,and
R11786	T24729	T24727	arg1Of	activation,constitutive
R11787	T24729	T24728	arg1Of	activation,STAT3
R11788	T24733	T24731	arg1Of	phosphorylation,IL-10-induced
R11789	T24733	T24732	arg1Of	phosphorylation,tyrosine
R11790	T24733	T24734	arg1Of	phosphorylation,of
R11791	T24733	T24736	arg1Of	phosphorylation,is
R11792	T24733	T24737	arg2Of	phosphorylation,suppressed
R11793	T24735	T24734	arg2Of	STAT3,of
R11794	T24737	T24722	arg1Of	suppressed,Despite
R11795	T24737	T24730	arg1Of	suppressed,","
R11796	T24737	T24736	arg2Of	suppressed,is
R11797	T24737	T24738	arg1Of	suppressed,in
R11798	T24737	T24743	arg1Of	suppressed,","
R11799	T24737	T24744	arg1Of	suppressed,in
R11800	T24742	T24738	arg2Of	cells,in
R11801	T24742	T24739	arg1Of	cells,RA
R11802	T24742	T24740	arg1Of	cells,CD4+
R11803	T24742	T24741	arg1Of	cells,T
R11804	T24745	T24744	arg2Of	contrast,in
R11805	T24745	T24746	arg1Of	contrast,to
R11806	T24750	T24746	arg2Of	cells,to
R11807	T24750	T24747	arg1Of	cells,normal
R11808	T24750	T24748	arg1Of	cells,CD4+
R11809	T24750	T24749	arg1Of	cells,T
R11810	T24750	T24751	arg1Of	cells,","
R11811	T24750	T24752	arg1Of	cells,where
R11812	T24754	T24753	arg1Of	phosphorylation,STAT3
R11813	T24754	T24755	arg1Of	phosphorylation,is
R11814	T24754	T24757	arg1Of	phosphorylation,inducible
R11815	T24755	T24752	arg2Of	is,where
R11816	T24757	T24755	arg2Of	inducible,is
R11817	T24757	T24756	arg1Of	inducible,dose-dependently
R11818	T24757	T24758	arg1Of	inducible,by
R11819	T24759	T24758	arg2Of	IL-10,by
R11820	T24761	T24760	arg1Of	IL-6,Serum
R11821	T24761	T24762	arg1Of	IL-6,from
R11822	T24761	T24765	arg1Of	IL-6,induces
R11823	T24764	T24762	arg2Of	patients,from
R11824	T24764	T24763	arg1Of	patients,RA
R11825	T24765	T24771	arg1Of	induces,in
R11826	T24765	T24777	arg1Of	induces,and
R11827	T24766	T24767	arg1Of	STAT3,but
R11828	T24767	T24765	arg2Of	but,induces
R11829	T24767	T24768	arg1Of	but,not
R11830	T24770	T24767	arg2Of	phosphorylation,but
R11831	T24770	T24769	arg1Of	phosphorylation,STAT1
R11832	T24775	T24771	arg2Of	cells,in
R11833	T24775	T24772	arg1Of	cells,normal
R11834	T24775	T24773	arg1Of	cells,CD4+
R11835	T24775	T24774	arg1Of	cells,T
R11836	T24777	T24776	arg1Of	and,","
R11837	T24779	T24778	arg1Of	IL-6,exogenous
R11838	T24779	T24780	arg1Of	IL-6,induces
R11839	T24780	T24777	arg2Of	induces,and
R11840	T24782	T24780	arg2Of	resistance,induces
R11841	T24782	T24781	arg1Of	resistance,the
R11842	T24782	T24783	arg1Of	resistance,to
R11843	T24785	T24783	arg2Of	inhibition,to
R11844	T24785	T24784	arg1Of	inhibition,IL-10
R11845	T24785	T24786	arg1Of	inhibition,of
R11846	T24788	T24786	arg2Of	production,of
R11847	T24788	T24787	arg1Of	production,IFN-γ
R11848	T24792	T24789	arg1Of	cells,RA
R11849	T24792	T24790	arg1Of	cells,CD4+
R11850	T24792	T24791	arg1Of	cells,T
R11851	T24792	T24793	arg1Of	cells,contain
R11852	T24792	T24799	arg1Of	cells,contain
R11853	T24793	T24798	arg1Of	contain,but
R11854	T24795	T24793	arg2Of	levels,contain
R11855	T24795	T24794	arg1Of	levels,higher
R11856	T24795	T24796	arg1Of	levels,of
R11857	T24797	T24796	arg2Of	SOCS1,of
R11858	T24799	T24798	arg2Of	contain,but
R11859	T24799	T24805	arg1Of	contain,in
R11860	T24801	T24799	arg2Of	levels,contain
R11861	T24801	T24800	arg1Of	levels,lower
R11862	T24801	T24802	arg1Of	levels,of
R11863	T24804	T24802	arg2Of	transcripts,of
R11864	T24804	T24803	arg1Of	transcripts,SOCS3
R11865	T24806	T24805	arg2Of	comparison,in
R11866	T24806	T24807	arg1Of	comparison,with
R11867	T24811	T24807	arg2Of	cells,with
R11868	T24811	T24808	arg1Of	cells,normal
R11869	T24811	T24809	arg1Of	cells,CD4+
R11870	T24811	T24810	arg1Of	cells,T
R11871	T24813	T24812	arg1Of	findings,These
R11872	T24813	T24814	arg1Of	findings,indicate
R11873	T24818	T24816	arg1Of	cells,CD4+
R11874	T24818	T24817	arg1Of	cells,T
R11875	T24818	T24819	arg1Of	cells,become
R11876	T24818	T24820	arg1Of	cells,resistant
R11877	T24818	T24835	arg1Of	cells,suggest
R11878	T24819	T24834	arg1Of	become,and
R11879	T24820	T24819	arg2Of	resistant,become
R11880	T24820	T24821	arg1Of	resistant,to
R11881	T24824	T24821	arg2Of	effect,to
R11882	T24824	T24822	arg1Of	effect,the
R11883	T24824	T24823	arg1Of	effect,inhibitory
R11884	T24824	T24825	arg1Of	effect,of
R11885	T24824	T24827	arg1Of	effect,before
R11886	T24824	T24829	arg1Of	effect,into
R11887	T24826	T24825	arg2Of	IL-10,of
R11888	T24828	T24827	arg2Of	migration,before
R11889	T24832	T24829	arg2Of	ST,into
R11890	T24832	T24830	arg1Of	ST,the
R11891	T24832	T24831	arg1Of	ST,inflamed
R11892	T24834	T24814	arg2Of	and,indicate
R11893	T24834	T24815	arg1Of	and,that
R11894	T24834	T24833	arg1Of	and,","
R11895	T24835	T24834	arg2Of	suggest,and
R11896	T24838	T24837	arg1Of	resistance,this
R11897	T24838	T24839	arg1Of	resistance,may
R11898	T24838	T24840	arg1Of	resistance,be
R11899	T24838	T24841	arg1Of	resistance,attributable
R11900	T24840	T24835	arg2Of	be,suggest
R11901	T24840	T24836	arg1Of	be,that
R11902	T24840	T24839	arg2Of	be,may
R11903	T24840	T24847	arg1Of	be,","
R11904	T24840	T24848	arg1Of	be,in
R11905	T24841	T24840	arg2Of	attributable,be
R11906	T24841	T24842	arg1Of	attributable,to
R11907	T24844	T24843	arg1Of	IL-10-dependent,impaired
R11908	T24846	T24842	arg2Of	activation,to
R11909	T24846	T24844	arg1Of	activation,IL-10-dependent
R11910	T24846	T24845	arg1Of	activation,STAT3
R11911	T24849	T24848	arg2Of	association,in
R11912	T24849	T24850	arg1Of	association,with
R11913	T24853	T24851	arg1Of	phosphorylation,sustained
R11914	T24853	T24852	arg1Of	phosphorylation,STAT3
R11915	T24853	T24854	arg1Of	phosphorylation,and
R11916	T24854	T24850	arg2Of	and,with
R11917	T24856	T24854	arg2Of	induction,and
R11918	T24856	T24855	arg1Of	induction,SOCS1
R11919	T24858	T24857	arg1Of	inhibition,IL-10-mediated
R11920	T24858	T24859	arg1Of	inhibition,of
R11921	T24858	T24864	arg1Of	inhibition,is
R11922	T24858	T24866	arg1Of	inhibition,dependent
R11923	T24863	T24859	arg2Of	production,of
R11924	T24863	T24860	arg1Of	production,CD4+
R11925	T24863	T24861	arg1Of	production,T-cell
R11926	T24863	T24862	arg1Of	production,cytokine
R11927	T24866	T24864	arg2Of	dependent,is
R11928	T24866	T24865	arg1Of	dependent,principally
R11929	T24866	T24867	arg1Of	dependent,on
R11930	T24869	T24867	arg2Of	inhibition,on
R11931	T24869	T24868	arg1Of	inhibition,its
R11932	T24869	T24870	arg1Of	inhibition,of
R11933	T24874	T24870	arg2Of	function,of
R11934	T24874	T24871	arg1Of	function,macrophage
R11935	T24874	T24872	arg1Of	function,antigen-presenting
R11936	T24874	T24873	arg1Of	function,cell
R11937	T24874	T24875	arg1Of	function,[
R11938	T24876	T24875	arg2Of	1,[
R11939	T24877	T24875	arg3Of	],[
R11940	T24883	T24880	arg1Of	effect,this
R11941	T24883	T24881	arg1Of	effect,indirect
R11942	T24883	T24882	arg1Of	effect,inhibitory
R11943	T24883	T24884	arg1Of	effect,is
R11944	T24883	T24885	arg2Of	effect,thought
R11945	T24883	T24887	arg1Of	effect,be
R11946	T24883	T24888	arg2Of	effect,restricted
R11947	T24885	T24878	arg1Of	thought,However
R11948	T24885	T24879	arg1Of	thought,","
R11949	T24885	T24884	arg2Of	thought,is
R11950	T24885	T24897	arg1Of	thought,","
R11951	T24885	T24898	arg1Of	thought,because
R11952	T24888	T24885	arg3Of	restricted,thought
R11953	T24888	T24886	arg1Of	restricted,to
R11954	T24888	T24887	arg2Of	restricted,be
R11955	T24888	T24889	arg1Of	restricted,at
R11956	T24891	T24889	arg2Of	site,at
R11957	T24891	T24890	arg1Of	site,the
R11958	T24891	T24892	arg1Of	site,of
R11959	T24894	T24892	arg2Of	activation,of
R11960	T24894	T24893	arg1Of	activation,T-cell
R11961	T24894	T24895	arg1Of	activation,in
R11962	T24896	T24895	arg2Of	RA,in
R11963	T24899	T24900	arg1Of	macrophages,in
R11964	T24899	T24903	arg1Of	macrophages,express
R11965	T24902	T24900	arg2Of	ST,in
R11966	T24902	T24901	arg1Of	ST,the
R11967	T24903	T24898	arg2Of	express,because
R11968	T24905	T24903	arg2Of	levels,express
R11969	T24905	T24904	arg1Of	levels,high
R11970	T24905	T24906	arg1Of	levels,of
R11971	T24907	T24908	arg1Of	cytokines,","
R11972	T24908	T24910	arg1Of	",",and
R11973	T24909	T24908	arg2Of	CD80,","
R11974	T24910	T24914	arg1Of	and,and
R11975	T24912	T24910	arg2Of	molecules,and
R11976	T24912	T24911	arg1Of	molecules,CD86
R11977	T24914	T24906	arg2Of	and,of
R11978	T24914	T24913	arg1Of	and,","
R11979	T24918	T24914	arg2Of	antigens,and
R11980	T24918	T24915	arg1Of	antigens,MHC
R11981	T24918	T24916	arg1Of	antigens,class
R11982	T24918	T24917	arg1Of	antigens,II
R11983	T24918	T24919	arg1Of	antigens,[
R11984	T24920	T24919	arg2Of	"10,18-20",[
R11985	T24921	T24919	arg3Of	],[
R11986	T24923	T24922	arg1Of	recently,More
R11987	T24925	T24926	arg1Of	IL-10,has
R11988	T24925	T24927	arg1Of	IL-10,been
R11989	T24925	T24928	arg2Of	IL-10,shown
R11990	T24925	T24930	arg1Of	IL-10,induce
R11991	T24925	T24936	arg1Of	IL-10,inhibiting
R11992	T24928	T24923	arg1Of	shown,recently
R11993	T24928	T24924	arg1Of	shown,","
R11994	T24928	T24926	arg2Of	shown,has
R11995	T24928	T24927	arg2Of	shown,been
R11996	T24930	T24928	arg3Of	induce,shown
R11997	T24930	T24929	arg1Of	induce,to
R11998	T24930	T24935	arg1Of	induce,by
R11999	T24934	T24930	arg2Of	unresponsiveness,induce
R12000	T24934	T24931	arg1Of	unresponsiveness,the
R12001	T24934	T24932	arg1Of	unresponsiveness,antigen-specific
R12002	T24934	T24933	arg1Of	unresponsiveness,T-cell
R12003	T24936	T24935	arg2Of	inhibiting,by
R12004	T24936	T24940	arg1Of	inhibiting,[
R12005	T24939	T24936	arg2Of	phosphorylation,inhibiting
R12006	T24939	T24937	arg1Of	phosphorylation,CD28
R12007	T24939	T24938	arg1Of	phosphorylation,tyrosine
R12008	T24941	T24940	arg2Of	33,[
R12009	T24942	T24940	arg3Of	],[
R12010	T24945	T24943	arg1Of	effect,This
R12011	T24945	T24944	arg1Of	effect,direct
R12012	T24945	T24947	arg1Of	effect,may
R12013	T24945	T24948	arg1Of	effect,be
R12014	T24945	T24949	arg2Of	effect,limited
R12015	T24949	T24946	arg1Of	limited,also
R12016	T24949	T24947	arg2Of	limited,may
R12017	T24949	T24948	arg2Of	limited,be
R12018	T24949	T24950	arg1Of	limited,in
R12019	T24949	T24954	arg1Of	limited,","
R12020	T24949	T24955	arg1Of	limited,because
R12021	T24953	T24950	arg2Of	patients,in
R12022	T24953	T24951	arg1Of	patients,active
R12023	T24953	T24952	arg1Of	patients,RA
R12024	T24960	T24956	arg1Of	cells,their
R12025	T24960	T24957	arg1Of	cells,PB
R12026	T24960	T24958	arg1Of	cells,CD4+
R12027	T24960	T24959	arg1Of	cells,T
R12028	T24960	T24961	arg1Of	cells,showed
R12029	T24961	T24955	arg2Of	showed,because
R12030	T24965	T24961	arg2Of	inhibition,showed
R12031	T24965	T24962	arg1Of	inhibition,a
R12032	T24965	T24963	arg1Of	inhibition,defective
R12033	T24965	T24964	arg1Of	inhibition,IL-10
R12034	T24965	T24966	arg1Of	inhibition,of
R12035	T24968	T24966	arg2Of	production,of
R12036	T24968	T24967	arg1Of	production,CD28-costimulated
R12037	T24968	T24969	arg1Of	production,of
R12038	T24971	T24972	arg1Of	IFN-γ,and
R12039	T24972	T24969	arg2Of	and,of
R12040	T24972	T24970	arg1Of	and,both
R12041	T24973	T24972	arg2Of	IL-2,and
R12042	T24975	T24974	arg1Of	cytokines,Numerous
R12043	T24975	T24976	arg1Of	cytokines,","
R12044	T24978	T24979	arg1Of	proinflammatory,and
R12045	T24980	T24979	arg2Of	anti-inflammatory,and
R12046	T24984	T24981	arg1Of	detected,","
R12047	T24984	T24982	arg2Of	detected,have
R12048	T24984	T24983	arg2Of	detected,been
R12049	T24984	T24985	arg1Of	detected,in
R12050	T24987	T24985	arg2Of	ST,in
R12051	T24987	T24986	arg1Of	ST,the
R12052	T24987	T24988	arg1Of	ST,of
R12053	T24989	T24988	arg2Of	RA,of
R12054	T24991	T24990	arg1Of	and,","
R12055	T24993	T24992	arg1Of	balance,the
R12056	T24993	T24994	arg1Of	balance,between
R12057	T24993	T24999	arg1Of	balance,regulates
R12058	T24998	T24994	arg2Of	activities,between
R12059	T24998	T24995	arg1Of	activities,these
R12060	T24998	T24996	arg1Of	activities,opposing
R12061	T24998	T24997	arg1Of	activities,cytokine
R12062	T24999	T24991	arg2Of	regulates,and
R12063	T24999	T25002	arg1Of	regulates,[
R12064	T25001	T24999	arg2Of	severity,regulates
R12065	T25001	T25000	arg1Of	severity,disease
R12066	T25003	T25002	arg2Of	10,[
R12067	T25004	T25002	arg3Of	],[
R12068	T25006	T25005	arg1Of	IL-10,Endogenous
R12069	T25006	T25007	arg1Of	IL-10,","
R12070	T25006	T25008	arg2Of	IL-10,produced
R12071	T25006	T25016	arg1Of	IL-10,inhibits
R12072	T25008	T25010	arg1Of	produced,by
R12073	T25010	T25009	arg1Of	by,mainly
R12074	T25011	T25012	arg1Of	macrophages,and
R12075	T25012	T25010	arg2Of	and,by
R12076	T25014	T25012	arg2Of	cells,and
R12077	T25014	T25013	arg1Of	cells,T
R12078	T25016	T25015	arg1Of	inhibits,","
R12079	T25016	T25023	arg1Of	inhibits,[
R12080	T25019	T25016	arg2Of	production,inhibits
R12081	T25019	T25017	arg1Of	production,proinflammatory
R12082	T25019	T25018	arg1Of	production,cytokine
R12083	T25019	T25020	arg1Of	production,by
R12084	T25022	T25020	arg2Of	cells,by
R12085	T25022	T25021	arg1Of	cells,ST
R12086	T25024	T25023	arg2Of	12,[
R12087	T25025	T25023	arg3Of	],[
R12088	T25030	T25028	arg1Of	activity,this
R12089	T25030	T25029	arg1Of	activity,regulatory
R12090	T25030	T25031	arg1Of	activity,seems
R12091	T25030	T25033	arg1Of	activity,be
R12092	T25030	T25034	arg2Of	activity,restricted
R12093	T25031	T25026	arg1Of	seems,However
R12094	T25031	T25027	arg1Of	seems,","
R12095	T25034	T25031	arg2Of	restricted,seems
R12096	T25034	T25032	arg1Of	restricted,to
R12097	T25034	T25033	arg2Of	restricted,be
R12098	T25034	T25035	arg1Of	restricted,during
R12099	T25037	T25035	arg2Of	inflammation,during
R12100	T25037	T25036	arg1Of	inflammation,chronic
R12101	T25039	T25038	arg1Of	activation,The
R12102	T25039	T25040	arg1Of	activation,of
R12103	T25039	T25057	arg1Of	activation,inhibits
R12104	T25045	T25043	arg1Of	kinase,extracellular
R12105	T25045	T25044	arg1Of	kinase,stimulus-regulated
R12106	T25045	T25046	arg1Of	kinase,and
R12107	T25048	T25046	arg2Of	kinase,and
R12108	T25048	T25047	arg1Of	kinase,p38
R12109	T25049	T25040	arg2Of	pathways,of
R12110	T25049	T25041	arg1Of	pathways,both
R12111	T25049	T25042	arg1Of	pathways,the
R12112	T25049	T25045	arg1Of	pathways,kinase
R12113	T25049	T25048	arg1Of	pathways,kinase
R12114	T25049	T25050	arg1Of	pathways,","
R12115	T25049	T25051	arg2Of	pathways,induced
R12116	T25053	T25054	arg1Of	TNF-α,and
R12117	T25054	T25051	arg1Of	and,induced
R12118	T25054	T25052	arg2Of	and,by
R12119	T25055	T25054	arg2Of	IL-1,and
R12120	T25057	T25056	arg1Of	inhibits,","
R12121	T25061	T25057	arg2Of	pathway,inhibits
R12122	T25061	T25058	arg1Of	pathway,the
R12123	T25061	T25059	arg1Of	pathway,Jak1–STAT3
R12124	T25061	T25060	arg1Of	pathway,signaling
R12125	T25061	T25062	arg2Of	pathway,shared
R12126	T25062	T25070	arg1Of	shared,[
R12127	T25064	T25065	arg1Of	IL-10,and
R12128	T25065	T25062	arg1Of	and,shared
R12129	T25065	T25063	arg2Of	and,by
R12130	T25065	T25067	arg1Of	and,in
R12131	T25066	T25065	arg2Of	IL-6,and
R12132	T25069	T25067	arg2Of	macrophages,in
R12133	T25069	T25068	arg1Of	macrophages,adhered
R12134	T25071	T25070	arg2Of	13,[
R12135	T25072	T25070	arg3Of	],[
R12136	T25074	T25073	arg1Of	importantly,More
R12137	T25078	T25076	arg1Of	activation,IL-10-mediated
R12138	T25078	T25077	arg1Of	activation,STAT3
R12139	T25078	T25079	arg1Of	activation,is
R12140	T25078	T25081	arg1Of	activation,undetectable
R12141	T25079	T25074	arg1Of	is,importantly
R12142	T25079	T25075	arg1Of	is,","
R12143	T25079	T25080	arg1Of	is,mostly
R12144	T25081	T25079	arg2Of	undetectable,is
R12145	T25081	T25082	arg1Of	undetectable,in
R12146	T25085	T25082	arg2Of	macrophages,in
R12147	T25085	T25083	arg1Of	macrophages,RA
R12148	T25085	T25084	arg1Of	macrophages,synovial
R12149	T25089	T25086	arg1Of	signaling,This
R12150	T25089	T25087	arg1Of	signaling,impaired
R12151	T25089	T25088	arg1Of	signaling,IL-10
R12152	T25089	T25090	arg1Of	signaling,is
R12153	T25089	T25092	arg2Of	signaling,induced
R12154	T25092	T25090	arg2Of	induced,is
R12155	T25092	T25091	arg1Of	induced,probably
R12156	T25092	T25100	arg1Of	induced,vivo
R12157	T25092	T25101	arg1Of	induced,","
R12158	T25092	T25102	arg1Of	induced,because
R12159	T25095	T25092	arg1Of	exposure,induced
R12160	T25095	T25093	arg2Of	exposure,by
R12161	T25095	T25094	arg1Of	exposure,chronic
R12162	T25095	T25096	arg1Of	exposure,to
R12163	T25098	T25096	arg2Of	complexes,to
R12164	T25098	T25097	arg1Of	complexes,immune
R12165	T25100	T25099	arg1Of	vivo,in
R12166	T25107	T25104	arg1Of	expression,cell
R12167	T25107	T25105	arg1Of	expression,surface
R12168	T25107	T25106	arg1Of	expression,IL-10R1
R12169	T25107	T25108	arg1Of	expression,and
R12170	T25108	T25103	arg1Of	and,both
R12171	T25108	T25112	arg1Of	and,are
R12172	T25108	T25113	arg2Of	and,suppressed
R12173	T25111	T25108	arg2Of	activation,and
R12174	T25111	T25109	arg1Of	activation,IL-10-induced
R12175	T25111	T25110	arg1Of	activation,Jak1
R12176	T25113	T25102	arg2Of	suppressed,because
R12177	T25113	T25112	arg2Of	suppressed,are
R12178	T25113	T25114	arg1Of	suppressed,in
R12179	T25116	T25114	arg2Of	macrophages,in
R12180	T25116	T25115	arg1Of	macrophages,IFN-γ-primed
R12181	T25121	T25119	arg1Of	C-dependent,protein
R12182	T25121	T25120	arg1Of	C-dependent,kinase
R12183	T25122	T25113	arg1Of	pathway,suppressed
R12184	T25122	T25117	arg2Of	pathway,by
R12185	T25122	T25118	arg1Of	pathway,a
R12186	T25122	T25121	arg1Of	pathway,C-dependent
R12187	T25122	T25123	arg1Of	pathway,following
R12188	T25124	T25123	arg2Of	ligation,following
R12189	T25124	T25125	arg1Of	ligation,of
R12190	T25130	T25125	arg2Of	receptor,of
R12191	T25130	T25126	arg1Of	receptor,the
R12192	T25130	T25127	arg1Of	receptor,IgG
R12193	T25130	T25128	arg1Of	receptor,Fc
R12194	T25130	T25129	arg1Of	receptor,gamma
R12195	T25130	T25131	arg1Of	receptor,[
R12196	T25132	T25131	arg2Of	14,[
R12197	T25133	T25131	arg3Of	],[
R12198	T25137	T25136	arg1Of	cells,dendritic
R12199	T25137	T25138	arg1Of	cells,from
R12200	T25137	T25142	arg1Of	cells,are
R12201	T25137	T25143	arg1Of	cells,resistant
R12202	T25141	T25138	arg2Of	fluids,from
R12203	T25141	T25139	arg1Of	fluids,RA
R12204	T25141	T25140	arg1Of	fluids,synovial
R12205	T25142	T25134	arg1Of	are,Furthermore
R12206	T25142	T25135	arg1Of	are,","
R12207	T25143	T25142	arg2Of	resistant,are
R12208	T25143	T25144	arg1Of	resistant,to
R12209	T25147	T25144	arg2Of	effect,to
R12210	T25147	T25145	arg1Of	effect,the
R12211	T25147	T25146	arg1Of	effect,immunoregulatory
R12212	T25147	T25148	arg1Of	effect,of
R12213	T25147	T25150	arg1Of	effect,due
R12214	T25149	T25148	arg2Of	IL-10,of
R12215	T25150	T25151	arg1Of	due,to
R12216	T25153	T25151	arg2Of	transport,to
R12217	T25153	T25152	arg2Of	transport,decreased
R12218	T25153	T25154	arg1Of	transport,of
R12219	T25153	T25157	arg1Of	transport,in
R12220	T25156	T25154	arg2Of	IL-10R1,of
R12221	T25156	T25155	arg1Of	IL-10R1,intracellular
R12222	T25159	T25157	arg2Of	presence,in
R12223	T25159	T25158	arg1Of	presence,the
R12224	T25159	T25160	arg1Of	presence,of
R12225	T25163	T25160	arg2Of	stimuli,of
R12226	T25163	T25161	arg1Of	stimuli,proinflammatory
R12227	T25163	T25162	arg1Of	stimuli,cytokine
R12228	T25163	T25165	arg1Of	stimuli,as
R12229	T25165	T25164	arg1Of	as,such
R12230	T25166	T25167	arg1Of	TNF-α,","
R12231	T25167	T25170	arg1Of	",",and
R12232	T25168	T25167	arg2Of	IL-1,","
R12233	T25170	T25165	arg2Of	and,as
R12234	T25170	T25169	arg1Of	and,","
R12235	T25173	T25170	arg2Of	factor,and
R12236	T25173	T25171	arg1Of	factor,granulocyte–macrophage
R12237	T25173	T25172	arg1Of	factor,colony-stimulating
R12238	T25173	T25174	arg1Of	factor,[
R12239	T25175	T25174	arg2Of	15,[
R12240	T25176	T25174	arg3Of	],[
R12241	T25177	T25178	arg1Of	We,have
R12242	T25177	T25179	arg1Of	We,demonstrated
R12243	T25179	T25178	arg2Of	demonstrated,have
R12244	T25182	T25181	arg1Of	resistance,the
R12245	T25182	T25183	arg1Of	resistance,of
R12246	T25182	T25188	arg1Of	resistance,to
R12247	T25182	T25190	arg1Of	resistance,may
R12248	T25182	T25191	arg1Of	resistance,be
R12249	T25182	T25192	arg2Of	resistance,associated
R12250	T25187	T25183	arg2Of	cells,of
R12251	T25187	T25184	arg1Of	cells,RA
R12252	T25187	T25185	arg1Of	cells,CD4+
R12253	T25187	T25186	arg1Of	cells,T
R12254	T25189	T25188	arg2Of	IL-10,to
R12255	T25192	T25179	arg2Of	associated,demonstrated
R12256	T25192	T25180	arg1Of	associated,that
R12257	T25192	T25190	arg2Of	associated,may
R12258	T25192	T25191	arg2Of	associated,be
R12259	T25192	T25193	arg1Of	associated,with
R12260	T25192	T25201	arg1Of	associated,with
R12261	T25193	T25199	arg1Of	with,but
R12262	T25197	T25193	arg2Of	activation,with
R12263	T25197	T25194	arg1Of	activation,defective
R12264	T25197	T25195	arg1Of	activation,IL-10-dependent
R12265	T25197	T25196	arg1Of	activation,STAT3
R12266	T25199	T25198	arg1Of	but,","
R12267	T25201	T25199	arg2Of	with,but
R12268	T25201	T25200	arg1Of	with,not
R12269	T25203	T25201	arg2Of	expression,with
R12270	T25203	T25202	arg1Of	expression,IL-10R1
R12271	T25205	T25204	arg1Of	effects,Inhibitory
R12272	T25205	T25206	arg1Of	effects,of
R12273	T25205	T25208	arg1Of	effects,on
R12274	T25205	T25213	arg1Of	effects,are
R12275	T25205	T25216	arg2Of	effects,modulated
R12276	T25207	T25206	arg2Of	IL-10,of
R12277	T25212	T25208	arg2Of	types,on
R12278	T25212	T25209	arg1Of	types,these
R12279	T25212	T25210	arg1Of	types,inflammatory
R12280	T25212	T25211	arg1Of	types,cell
R12281	T25216	T25213	arg2Of	modulated,are
R12282	T25216	T25214	arg1Of	modulated,therefore
R12283	T25216	T25215	arg1Of	modulated,differentially
R12284	T25216	T25217	arg1Of	modulated,at
R12285	T25216	T25222	arg1Of	modulated,under
R12286	T25221	T25217	arg2Of	level,at
R12287	T25221	T25218	arg1Of	level,the
R12288	T25221	T25219	arg1Of	level,signal
R12289	T25221	T25220	arg1Of	level,transduction
R12290	T25225	T25222	arg2Of	environment,under
R12291	T25225	T25223	arg1Of	environment,the
R12292	T25225	T25224	arg1Of	environment,inflammatory
R12293	T25225	T25226	arg1Of	environment,in
R12294	T25227	T25226	arg2Of	RA,in
R12295	T25229	T25228	arg2Of	association,In
R12296	T25229	T25230	arg1Of	association,with
R12297	T25232	T25231	arg1Of	IL-10-mediated,impaired
R12298	T25234	T25230	arg2Of	activation,with
R12299	T25234	T25232	arg1Of	activation,IL-10-mediated
R12300	T25234	T25233	arg1Of	activation,STAT3
R12301	T25236	T25237	arg1Of	STAT3,was
R12302	T25236	T25238	arg2Of	STAT3,found
R12303	T25236	T25240	arg1Of	STAT3,be
R12304	T25238	T25228	arg1Of	found,In
R12305	T25238	T25235	arg1Of	found,","
R12306	T25238	T25237	arg2Of	found,was
R12307	T25240	T25238	arg3Of	be,found
R12308	T25240	T25239	arg1Of	be,to
R12309	T25241	T25240	arg2Of	tyrosine,be
R12310	T25241	T25242	arg2Of	tyrosine,phosphorylated
R12311	T25241	T25250	arg1Of	tyrosine,in
R12312	T25242	T25243	arg1Of	phosphorylated,persistently
R12313	T25243	T25244	arg1Of	persistently,(
R12314	T25247	T25245	arg1Of	6,up
R12315	T25247	T25246	arg1Of	6,to
R12316	T25248	T25244	arg2Of	hours,(
R12317	T25248	T25247	arg1Of	hours,6
R12318	T25249	T25244	arg3Of	),(
R12319	T25252	T25251	arg1Of	isolated,freshly
R12320	T25253	T25254	arg1Of	PB,and
R12321	T25255	T25254	arg2Of	ST,and
R12322	T25258	T25250	arg2Of	cells,in
R12323	T25258	T25252	arg1Of	cells,isolated
R12324	T25258	T25253	arg1Of	cells,PB
R12325	T25258	T25255	arg1Of	cells,ST
R12326	T25258	T25256	arg1Of	cells,CD4+
R12327	T25258	T25257	arg1Of	cells,T
R12328	T25258	T25259	arg1Of	cells,from
R12329	T25261	T25259	arg2Of	patients,from
R12330	T25261	T25260	arg1Of	patients,RA
R12331	T25262	T25263	arg1Of	STAT3,is
R12332	T25262	T25264	arg2Of	STAT3,activated
R12333	T25264	T25263	arg2Of	activated,is
R12334	T25264	T25294	arg1Of	activated,","
R12335	T25264	T25295	arg1Of	activated,in
R12336	T25267	T25264	arg1Of	variety,activated
R12337	T25267	T25265	arg2Of	variety,by
R12338	T25267	T25266	arg1Of	variety,a
R12339	T25267	T25268	arg1Of	variety,of
R12340	T25269	T25270	arg1Of	cytokines,","
R12341	T25270	T25268	arg2Of	",",of
R12342	T25274	T25270	arg2Of	family,","
R12343	T25274	T25271	arg1Of	family,notably
R12344	T25274	T25272	arg1Of	family,the
R12345	T25274	T25273	arg1Of	family,IL-6
R12346	T25274	T25275	arg1Of	family,of
R12347	T25276	T25277	arg1Of	cytokines,(
R12348	T25276	T25291	arg1Of	cytokines,and
R12349	T25279	T25280	arg1Of	IL-6,","
R12350	T25280	T25282	arg1Of	",",","
R12351	T25281	T25280	arg2Of	IL-11,","
R12352	T25282	T25287	arg1Of	",",and
R12353	T25285	T25282	arg2Of	factor,","
R12354	T25285	T25283	arg1Of	factor,leukemia
R12355	T25285	T25284	arg1Of	factor,inhibitory
R12356	T25287	T25277	arg2Of	and,(
R12357	T25287	T25278	arg1Of	and,e.g.
R12358	T25287	T25286	arg1Of	and,","
R12359	T25289	T25287	arg2Of	M,and
R12360	T25289	T25288	arg1Of	M,oncostatin
R12361	T25290	T25277	arg3Of	),(
R12362	T25291	T25275	arg2Of	and,of
R12363	T25293	T25291	arg2Of	factors,and
R12364	T25293	T25292	arg1Of	factors,growth
R12365	T25296	T25295	arg2Of	addition,in
R12366	T25296	T25297	arg1Of	addition,to
R12367	T25298	T25297	arg2Of	IL-10,to
R12368	T25298	T25299	arg1Of	IL-10,[
R12369	T25300	T25299	arg2Of	4,[
R12370	T25301	T25299	arg3Of	],[
R12371	T25304	T25302	arg2Of	cytokines,Of
R12372	T25304	T25303	arg1Of	cytokines,these
R12373	T25306	T25307	arg1Of	IL-6,plays
R12374	T25306	T25312	arg1Of	IL-6,eliciting
R12375	T25307	T25302	arg1Of	plays,Of
R12376	T25307	T25305	arg1Of	plays,","
R12377	T25307	T25311	arg1Of	plays,in
R12378	T25310	T25307	arg2Of	role,plays
R12379	T25310	T25308	arg1Of	role,a
R12380	T25310	T25309	arg1Of	role,predominant
R12381	T25312	T25311	arg2Of	eliciting,in
R12382	T25315	T25312	arg2Of	reaction,eliciting
R12383	T25315	T25313	arg1Of	reaction,a
R12384	T25315	T25314	arg1Of	reaction,systemic
R12385	T25315	T25317	arg1Of	reaction,as
R12386	T25317	T25316	arg1Of	as,such
R12387	T25321	T25317	arg2Of	response,as
R12388	T25321	T25318	arg1Of	response,the
R12389	T25321	T25319	arg1Of	response,acute
R12390	T25321	T25320	arg1Of	response,phase
R12391	T25321	T25322	arg1Of	response,in
R12392	T25321	T25325	arg1Of	response,","
R12393	T25321	T25326	arg1Of	response,due
R12394	T25321	T25331	arg1Of	response,in
R12395	T25324	T25322	arg2Of	RA,in
R12396	T25324	T25323	arg1Of	RA,active
R12397	T25326	T25327	arg1Of	due,mainly
R12398	T25326	T25328	arg1Of	due,to
R12399	T25330	T25328	arg2Of	abundance,to
R12400	T25330	T25329	arg1Of	abundance,its
R12401	T25334	T25331	arg2Of	circulation,in
R12402	T25334	T25332	arg1Of	circulation,the
R12403	T25334	T25333	arg1Of	circulation,blood
R12404	T25334	T25335	arg1Of	circulation,[
R12405	T25336	T25335	arg2Of	27,[
R12406	T25337	T25335	arg3Of	],[
R12407	T25338	T25339	arg1Of	Consistent,with
R12408	T25341	T25339	arg2Of	notion,with
R12409	T25341	T25340	arg1Of	notion,this
R12410	T25343	T25344	arg1Of	IL-6,was
R12411	T25344	T25358	arg1Of	was,and
R12412	T25348	T25344	arg2Of	factor,was
R12413	T25348	T25345	arg1Of	factor,the
R12414	T25348	T25346	arg1Of	factor,major
R12415	T25348	T25347	arg1Of	factor,STAT3-activating
R12416	T25348	T25349	arg2Of	factor,contained
R12417	T25349	T25350	arg1Of	contained,in
R12418	T25352	T25350	arg2Of	serum,in
R12419	T25352	T25351	arg1Of	serum,the
R12420	T25352	T25353	arg1Of	serum,of
R12421	T25356	T25353	arg2Of	patients,of
R12422	T25356	T25354	arg1Of	patients,active
R12423	T25356	T25355	arg1Of	patients,RA
R12424	T25358	T25338	arg1Of	and,Consistent
R12425	T25358	T25342	arg1Of	and,","
R12426	T25358	T25357	arg1Of	and,","
R12427	T25360	T25359	arg1Of	responsiveness,the
R12428	T25360	T25361	arg1Of	responsiveness,to
R12429	T25360	T25363	arg1Of	responsiveness,was
R12430	T25360	T25364	arg2Of	responsiveness,suppressed
R12431	T25362	T25361	arg2Of	IL-10,to
R12432	T25364	T25358	arg2Of	suppressed,and
R12433	T25364	T25363	arg2Of	suppressed,was
R12434	T25364	T25365	arg1Of	suppressed,in
R12435	T25364	T25370	arg1Of	suppressed,after
R12436	T25369	T25365	arg2Of	cells,in
R12437	T25369	T25366	arg1Of	cells,normal
R12438	T25369	T25367	arg1Of	cells,CD4+
R12439	T25369	T25368	arg1Of	cells,T
R12440	T25372	T25370	arg2Of	hours,after
R12441	T25372	T25371	arg1Of	hours,36
R12442	T25372	T25373	arg1Of	hours,of
R12443	T25374	T25373	arg2Of	incubation,of
R12444	T25374	T25375	arg1Of	incubation,with
R12445	T25376	T25375	arg2Of	IL-6,with
R12446	T25378	T25377	arg1Of	results,These
R12447	T25378	T25379	arg1Of	results,suggest
R12448	T25385	T25382	arg1Of	activation,the
R12449	T25385	T25383	arg1Of	activation,sustained
R12450	T25385	T25384	arg1Of	activation,STAT3
R12451	T25385	T25386	arg1Of	activation,and
R12452	T25386	T25381	arg1Of	and,both
R12453	T25386	T25398	arg1Of	and,may
R12454	T25386	T25399	arg1Of	and,be
R12455	T25386	T25400	arg2Of	and,induced
R12456	T25388	T25386	arg2Of	resistance,and
R12457	T25388	T25387	arg1Of	resistance,the
R12458	T25388	T25389	arg1Of	resistance,to
R12459	T25391	T25389	arg2Of	inhibition,to
R12460	T25391	T25390	arg1Of	inhibition,IL-10
R12461	T25391	T25392	arg2Of	inhibition,found
R12462	T25392	T25393	arg1Of	found,in
R12463	T25397	T25393	arg2Of	cells,in
R12464	T25397	T25394	arg1Of	cells,RA
R12465	T25397	T25395	arg1Of	cells,CD4+
R12466	T25397	T25396	arg1Of	cells,T
R12467	T25400	T25379	arg2Of	induced,suggest
R12468	T25400	T25380	arg1Of	induced,that
R12469	T25400	T25398	arg2Of	induced,may
R12470	T25400	T25399	arg2Of	induced,be
R12471	T25400	T25401	arg1Of	induced,after
R12472	T25403	T25401	arg2Of	exposure,after
R12473	T25403	T25402	arg1Of	exposure,chronic
R12474	T25403	T25405	arg1Of	exposure,vivo
R12475	T25403	T25406	arg1Of	exposure,to
R12476	T25405	T25404	arg1Of	vivo,in
R12477	T25408	T25406	arg2Of	concentrations,to
R12478	T25408	T25407	arg1Of	concentrations,high
R12479	T25408	T25409	arg1Of	concentrations,of
R12480	T25411	T25409	arg2Of	IL-6,of
R12481	T25411	T25410	arg1Of	IL-6,serum
R12482	T25415	T25412	arg1Of	is,However
R12483	T25415	T25413	arg1Of	is,","
R12484	T25415	T25416	arg1Of	is,also
R12485	T25417	T25415	arg2Of	possible,is
R12486	T25420	T25419	arg1Of	activity,STAT3
R12487	T25420	T25421	arg1Of	activity,could
R12488	T25420	T25422	arg1Of	activity,be
R12489	T25420	T25424	arg2Of	activity,induced
R12490	T25424	T25414	arg1Of	induced,it
R12491	T25424	T25415	arg1Of	induced,is
R12492	T25424	T25417	arg1Of	induced,possible
R12493	T25424	T25418	arg1Of	induced,that
R12494	T25424	T25421	arg2Of	induced,could
R12495	T25424	T25422	arg2Of	induced,be
R12496	T25424	T25423	arg1Of	induced,constitutively
R12497	T25424	T25425	arg1Of	induced,in
R12498	T25424	T25429	arg1Of	induced,by
R12499	T25424	T25434	arg1Of	induced,","
R12500	T25424	T25435	modOf	induced,leading
R12501	T25424	T25444	arg1Of	induced,","
R12502	T25424	T25445	arg1Of	induced,because
R12503	T25428	T25425	arg2Of	cells,in
R12504	T25428	T25426	arg1Of	cells,CD4+
R12505	T25428	T25427	arg1Of	cells,T
R12506	T25433	T25429	arg2Of	secretion,by
R12507	T25433	T25430	arg1Of	secretion,their
R12508	T25433	T25431	arg1Of	secretion,own
R12509	T25433	T25432	arg1Of	secretion,IL-10
R12510	T25435	T25436	arg1Of	leading,to
R12511	T25438	T25436	arg2Of	loss,to
R12512	T25438	T25437	arg1Of	loss,the
R12513	T25438	T25439	arg1Of	loss,of
R12514	T25438	T25441	arg1Of	loss,to
R12515	T25440	T25439	arg2Of	sensitivity,of
R12516	T25443	T25441	arg2Of	IL-10,to
R12517	T25443	T25442	arg1Of	IL-10,exogenous
R12518	T25449	T25446	arg1Of	cells,RA
R12519	T25449	T25447	arg1Of	cells,CD4+
R12520	T25449	T25448	arg1Of	cells,T
R12521	T25449	T25450	arg1Of	cells,in
R12522	T25449	T25453	arg1Of	cells,are
R12523	T25449	T25454	arg1Of	cells,capable
R12524	T25449	T25456	arg1Of	cells,producing
R12525	T25452	T25450	arg2Of	ST,in
R12526	T25452	T25451	arg1Of	ST,the
R12527	T25453	T25445	arg2Of	are,because
R12528	T25454	T25453	arg2Of	capable,are
R12529	T25454	T25455	arg1Of	capable,of
R12530	T25456	T25455	arg2Of	producing,of
R12531	T25458	T25456	arg2Of	levels,producing
R12532	T25458	T25457	arg1Of	levels,significant
R12533	T25458	T25459	arg1Of	levels,of
R12534	T25460	T25459	arg2Of	IL-10,of
R12535	T25460	T25461	arg1Of	IL-10,[
R12536	T25462	T25461	arg2Of	34,[
R12537	T25463	T25461	arg3Of	],[
R12538	T25466	T25464	arg1Of	cells,CD4+
R12539	T25466	T25465	arg1Of	cells,T
R12540	T25466	T25467	arg2Of	cells,isolated
R12541	T25466	T25474	arg1Of	cells,showed
R12542	T25467	T25468	arg1Of	isolated,from
R12543	T25470	T25468	arg2Of	ST,from
R12544	T25470	T25469	arg1Of	ST,the
R12545	T25470	T25471	arg1Of	ST,of
R12546	T25472	T25471	arg2Of	RA,of
R12547	T25474	T25473	arg1Of	showed,also
R12548	T25476	T25474	arg2Of	defect,showed
R12549	T25476	T25475	arg1Of	defect,a
R12550	T25476	T25477	arg1Of	defect,in
R12551	T25482	T25477	arg2Of	pathway,in
R12552	T25482	T25478	arg1Of	pathway,the
R12553	T25482	T25479	arg1Of	pathway,IL-10-induced
R12554	T25482	T25480	arg1Of	pathway,STAT3
R12555	T25482	T25481	arg1Of	pathway,signaling
R12556	T25484	T25506	arg1Of	is,","
R12557	T25484	T25507	arg1Of	is,because
R12558	T25486	T25484	arg2Of	probable,is
R12559	T25486	T25485	arg1Of	probable,most
R12560	T25489	T25488	arg1Of	resistance,the
R12561	T25489	T25490	arg1Of	resistance,of
R12562	T25489	T25494	arg1Of	resistance,to
R12563	T25489	T25496	arg1Of	resistance,can
R12564	T25489	T25497	arg1Of	resistance,be
R12565	T25489	T25499	arg2Of	resistance,augmented
R12566	T25493	T25490	arg2Of	cells,of
R12567	T25493	T25491	arg1Of	cells,CD4+
R12568	T25493	T25492	arg1Of	cells,T
R12569	T25495	T25494	arg2Of	IL-10,to
R12570	T25499	T25483	arg1Of	augmented,It
R12571	T25499	T25484	arg1Of	augmented,is
R12572	T25499	T25486	arg1Of	augmented,probable
R12573	T25499	T25487	arg1Of	augmented,that
R12574	T25499	T25496	arg2Of	augmented,can
R12575	T25499	T25497	arg2Of	augmented,be
R12576	T25499	T25498	arg1Of	augmented,even
R12577	T25499	T25500	arg1Of	augmented,after
R12578	T25501	T25500	arg2Of	migration,after
R12579	T25501	T25502	arg1Of	migration,into
R12580	T25505	T25502	arg2Of	ST,into
R12581	T25505	T25503	arg1Of	ST,the
R12582	T25505	T25504	arg1Of	ST,inflamed
R12583	T25508	T25509	arg1Of	IL-6,is
R12584	T25508	T25511	arg2Of	IL-6,concentrated
R12585	T25511	T25507	arg2Of	concentrated,because
R12586	T25511	T25509	arg2Of	concentrated,is
R12587	T25511	T25510	arg1Of	concentrated,highly
R12588	T25511	T25512	arg1Of	concentrated,compared
R12589	T25511	T25517	arg1Of	concentrated,[
R12590	T25513	T25512	arg2Of	with,compared
R12591	T25516	T25513	arg2Of	level,with
R12592	T25516	T25514	arg1Of	level,the
R12593	T25516	T25515	arg1Of	level,blood
R12594	T25518	T25517	arg2Of	27,[
R12595	T25519	T25517	arg3Of	],[
R12596	T25521	T25520	arg2Of	addition,In
R12597	T25524	T25523	arg1Of	involvement,the
R12598	T25524	T25525	arg1Of	involvement,of
R12599	T25524	T25533	arg1Of	involvement,was
R12600	T25524	T25534	arg2Of	involvement,suggested
R12601	T25529	T25525	arg2Of	cytokines,of
R12602	T25529	T25526	arg1Of	cytokines,other
R12603	T25529	T25527	arg1Of	cytokines,essential
R12604	T25529	T25528	arg1Of	cytokines,proinflammatory
R12605	T25529	T25530	arg1Of	cytokines,in
R12606	T25532	T25530	arg2Of	process,in
R12607	T25532	T25531	arg1Of	process,this
R12608	T25534	T25520	arg1Of	suggested,In
R12609	T25534	T25522	arg1Of	suggested,","
R12610	T25534	T25533	arg2Of	suggested,was
R12611	T25538	T25534	arg1Of	experiments,suggested
R12612	T25538	T25535	arg2Of	experiments,by
R12613	T25538	T25536	arg1Of	experiments,our
R12614	T25538	T25537	arg1Of	experiments,preliminary
R12615	T25538	T25539	arg1Of	experiments,demonstrating
R12616	T25543	T25541	arg1Of	inhibition,IL-10-mediated
R12617	T25543	T25542	arg1Of	inhibition,IFN-γ
R12618	T25543	T25544	arg1Of	inhibition,in
R12619	T25543	T25548	arg1Of	inhibition,was
R12620	T25543	T25549	arg2Of	inhibition,reduced
R12621	T25547	T25544	arg2Of	cells,in
R12622	T25547	T25545	arg1Of	cells,CD4+
R12623	T25547	T25546	arg1Of	cells,T
R12624	T25549	T25539	arg2Of	reduced,demonstrating
R12625	T25549	T25540	arg1Of	reduced,that
R12626	T25549	T25548	arg2Of	reduced,was
R12627	T25549	T25550	arg1Of	reduced,by
R12628	T25549	T25556	arg1Of	reduced,","
R12629	T25549	T25557	arg1Of	reduced,although
R12630	T25549	T25559	arg1Of	reduced,effectively
R12631	T25551	T25550	arg2Of	pretreatment,by
R12632	T25551	T25552	arg1Of	pretreatment,with
R12633	T25553	T25554	arg1Of	IL-1β,and
R12634	T25554	T25552	arg2Of	and,with
R12635	T25555	T25554	arg2Of	TNF-α,and
R12636	T25559	T25558	arg1Of	effectively,less
R12637	T25559	T25560	arg1Of	effectively,than
R12638	T25561	T25560	arg2Of	by,than
R12639	T25562	T25561	arg2Of	IL-6,by
R12640	T25562	T25563	arg1Of	IL-6,(
R12641	T25564	T25563	arg2Of	data,(
R12642	T25564	T25566	arg2Of	data,shown
R12643	T25566	T25565	arg1Of	shown,not
R12644	T25580	T25568	arg1Of	be,Furthermore
R12645	T25580	T25569	arg1Of	be,","
R12646	T25580	T25579	arg2Of	be,could
R12647	T25580	T25589	arg1Of	be,","
R12648	T25580	T25590	arg1Of	be,because
R12649	T25567	T25563	arg3Of	),(
R12650	T25581	T25580	arg2Of	responsible,be
R12651	T25581	T25582	arg1Of	responsible,for
R12652	T25570	T25571	arg1Of	IFN-γ,and
R12653	T25585	T25582	arg2Of	signaling,for
R12654	T25585	T25583	arg1Of	signaling,impaired
R12655	T25585	T25584	arg1Of	signaling,IL-10
R12656	T25585	T25586	arg1Of	signaling,in
R12657	T25571	T25573	arg2Of	and,produced
R12658	T25588	T25586	arg2Of	ST,in
R12659	T25588	T25587	arg1Of	ST,the
R12660	T25592	T25591	arg1Of	infiltrates,T-cell
R12661	T25592	T25593	arg1Of	infiltrates,produce
R12662	T25593	T25590	arg2Of	produce,because
R12663	T25593	T25596	arg1Of	produce,[
R12664	T25571	T25579	arg1Of	and,could
R12665	T25595	T25593	arg2Of	cytokines,produce
R12666	T25595	T25594	arg1Of	cytokines,both
R12667	T25571	T25580	arg1Of	and,be
R12668	T25571	T25581	arg1Of	and,responsible
R12669	T25597	T25596	arg2Of	"34,35",[
R12670	T25572	T25571	arg2Of	IL-10,and
R12671	T25598	T25596	arg3Of	],[
R12672	T25573	T25578	arg1Of	produced,themselves
R12673	T25602	T25599	arg2Of	fashion,In
R12674	T25602	T25600	arg1Of	fashion,an
R12675	T25602	T25601	arg1Of	fashion,autocrine
R12676	T25577	T25573	arg1Of	cells,produced
R12677	T25604	T25605	arg1Of	IL-10,may
R12678	T25604	T25607	arg1Of	IL-10,stimulate
R12679	T25607	T25605	arg2Of	stimulate,may
R12680	T25607	T25606	arg1Of	stimulate,persistently
R12681	T25607	T25610	arg1Of	stimulate,and
R12682	T25609	T25607	arg2Of	activation,stimulate
R12683	T25609	T25608	arg1Of	activation,STAT3
R12684	T25610	T25599	arg1Of	and,In
R12685	T25610	T25603	arg1Of	and,","
R12686	T25611	T25612	arg1Of	IFN-γ,can
R12687	T25611	T25613	arg1Of	IFN-γ,induce
R12688	T25577	T25574	arg2Of	cells,by
R12689	T25613	T25610	arg2Of	induce,and
R12690	T25613	T25612	arg2Of	induce,can
R12691	T25613	T25616	arg1Of	induce,as
R12692	T25577	T25575	arg1Of	cells,CD4+
R12693	T25577	T25576	arg1Of	cells,T
R12694	T25615	T25613	arg2Of	protein,induce
R12695	T25615	T25614	arg1Of	protein,SOCS1
R12696	T25677	T25675	arg2Of	patients,from
R12697	T25619	T25616	arg2Of	inhibitor,as
R12698	T25619	T25617	arg1Of	inhibitor,a
R12699	T25619	T25618	arg1Of	inhibitor,crosstalk
R12700	T25619	T25620	arg1Of	inhibitor,of
R12701	T25619	T25623	arg1Of	inhibitor,[
R12702	T25622	T25620	arg2Of	signaling,of
R12703	T25622	T25621	arg1Of	signaling,IL-10
R12704	T25624	T25623	arg2Of	32,[
R12705	T25625	T25623	arg3Of	],[
R12706	T25677	T25676	arg1Of	patients,RA
R12707	T25677	T25678	arg1Of	patients,[
R12708	T25628	T25626	arg1Of	effect,The
R12709	T25628	T25627	arg1Of	effect,T-cell-inhibitory
R12710	T25628	T25629	arg1Of	effect,of
R12711	T25628	T25631	arg1Of	effect,may
R12712	T25628	T25633	arg1Of	effect,be
R12713	T25628	T25634	arg2Of	effect,modulated
R12714	T25679	T25678	arg2Of	36,[
R12715	T25630	T25629	arg2Of	IL-10,of
R12716	T25680	T25678	arg3Of	],[
R12717	T25634	T25631	arg2Of	modulated,may
R12718	T25634	T25632	arg1Of	modulated,therefore
R12719	T25634	T25633	arg2Of	modulated,be
R12720	T25634	T25635	arg1Of	modulated,complicatedly
R12721	T25634	T25636	arg1Of	modulated,upon
R12722	T25681	T25682	arg1Of	IL-6,is
R12723	T25637	T25636	arg2Of	exposure,upon
R12724	T25637	T25638	arg1Of	exposure,to
R12725	T25686	T25682	arg2Of	factor,is
R12726	T25641	T25638	arg2Of	environment,to
R12727	T25641	T25639	arg1Of	environment,an
R12728	T25641	T25640	arg1Of	environment,inflammatory
R12729	T25641	T25642	arg1Of	environment,in
R12730	T25641	T25645	arg1Of	environment,","
R12731	T25641	T25646	arg1Of	environment,where
R12732	T25644	T25642	arg2Of	joints,in
R12733	T25644	T25643	arg1Of	joints,RA
R12734	T25686	T25683	arg1Of	factor,the
R12735	T25648	T25647	arg1Of	cytokines,many
R12736	T25648	T25649	arg1Of	cytokines,are
R12737	T25648	T25650	arg1Of	cytokines,present
R12738	T25686	T25684	arg1Of	factor,major
R12739	T25649	T25646	arg2Of	are,where
R12740	T25649	T25651	arg1Of	are,substantially
R12741	T25649	T25652	arg1Of	are,[
R12742	T25650	T25649	arg2Of	present,are
R12743	T25686	T25685	arg1Of	factor,STAT3-activating
R12744	T25686	T25687	arg1Of	factor,present
R12745	T25686	T25691	arg1Of	factor,","
R12746	T25653	T25652	arg2Of	10,[
R12747	T25686	T25692	arg1Of	factor,which
R12748	T25654	T25652	arg3Of	],[
R12749	T25686	T25693	arg1Of	factor,has
R12750	T25687	T25688	arg1Of	present,in
R12751	T25656	T25655	arg1Of	activation,STAT3
R12752	T25690	T25688	arg2Of	fluid,in
R12753	T25656	T25657	arg1Of	activation,has
R12754	T25656	T25658	arg1Of	activation,been
R12755	T25656	T25659	arg2Of	activation,implicated
R12756	T25659	T25657	arg2Of	implicated,has
R12757	T25659	T25658	arg2Of	implicated,been
R12758	T25659	T25660	arg1Of	implicated,in
R12759	T25690	T25689	arg1Of	fluid,synovial
R12760	T25662	T25660	arg2Of	pathogenesis,in
R12761	T25662	T25661	arg1Of	pathogenesis,the
R12762	T25662	T25663	arg1Of	pathogenesis,of
R12763	T25664	T25663	arg2Of	RA,of
R12764	T25666	T25665	arg1Of	STAT3,Active
R12765	T25666	T25667	arg1Of	STAT3,is
R12766	T25666	T25669	arg2Of	STAT3,expressed
R12767	T25693	T25697	arg1Of	has,in
R12768	T25669	T25667	arg2Of	expressed,is
R12769	T25669	T25668	arg1Of	expressed,constitutively
R12770	T25669	T25670	arg1Of	expressed,in
R12771	T25696	T25693	arg2Of	role,has
R12772	T25674	T25670	arg2Of	cells,in
R12773	T25674	T25671	arg1Of	cells,synovial
R12774	T25674	T25672	arg1Of	cells,fluid
R12775	T25674	T25673	arg1Of	cells,mononuclear
R12776	T25674	T25675	arg1Of	cells,from
R12777	T25696	T25694	arg1Of	role,a
R12778	T25696	T25695	arg1Of	role,crucial
R12779	T25699	T25697	arg2Of	activation,in
R12780	T25699	T25698	arg1Of	activation,the
R12781	T25699	T25700	arg1Of	activation,of
R12782	T25702	T25700	arg2Of	functions,of
R12783	T25775	T25776	arg1Of	survival,and
R12784	T25776	T25773	arg2Of	and,in
R12785	T25776	T25774	arg1Of	and,the
R12786	T25776	T25778	arg1Of	and,of
R12787	T25702	T25701	arg1Of	functions,monocyte
R12788	T25777	T25776	arg2Of	expansion,and
R12789	T25702	T25704	arg1Of	functions,as
R12790	T25704	T25703	arg1Of	as,such
R12791	T25782	T25778	arg2Of	fibroblasts,of
R12792	T25782	T25779	arg1Of	fibroblasts,growth
R12793	T25782	T25780	arg1Of	fibroblasts,factor-dependent
R12794	T25782	T25781	arg1Of	fibroblasts,synovial
R12795	T25706	T25704	arg2Of	expression,as
R12796	T25784	T25783	arg2Of	38,[
R12797	T25785	T25783	arg3Of	],[
R12798	T25706	T25705	arg1Of	expression,gene
R12799	T25706	T25707	arg1Of	expression,of
R12800	T25706	T25718	arg1Of	expression,of
R12801	T25789	T25788	arg1Of	significance,the
R12802	T25789	T25790	arg1Of	significance,of
R12803	T25789	T25794	arg1Of	significance,in
R12804	T25789	T25798	arg1Of	significance,has
R12805	T25789	T25799	arg1Of	significance,been
R12806	T25789	T25800	arg2Of	significance,suggested
R12807	T25707	T25717	arg1Of	of,and
R12808	T25793	T25790	arg2Of	signaling,of
R12809	T25793	T25791	arg1Of	signaling,persistent
R12810	T25793	T25792	arg1Of	signaling,STAT3
R12811	T25797	T25794	arg2Of	arthritis,in
R12812	T25797	T25795	arg1Of	arthritis,Th1-cell-dominated
R12813	T25797	T25796	arg1Of	arthritis,autoimmune
R12814	T25712	T25709	arg1Of	type,Fc
R12815	T25800	T25786	arg1Of	suggested,Furthermore
R12816	T25800	T25787	arg1Of	suggested,","
R12817	T25800	T25798	arg2Of	suggested,has
R12818	T25800	T25799	arg2Of	suggested,been
R12819	T25802	T25800	arg1Of	studies,suggested
R12820	T25802	T25801	arg2Of	studies,by
R12821	T25802	T25803	arg1Of	studies,of
R12822	T25802	T25807	arg1Of	studies,","
R12823	T25802	T25808	arg2Of	studies,in
R12824	T25802	T25809	arg1Of	studies,which
R12825	T25806	T25803	arg2Of	mice,of
R12826	T25806	T25804	arg1Of	mice,the
R12827	T25806	T25805	arg1Of	mice,gp130F759/F759
R12828	T25712	T25710	arg1Of	type,gamma
R12829	T25712	T25711	arg1Of	type,receptor
R12830	T25712	T25713	arg1Of	type,I
R12831	T25712	T25714	arg1Of	type,and
R12832	T25714	T25707	arg2Of	and,of
R12833	T25815	T25811	arg1Of	site,Src
R12834	T25815	T25812	arg1Of	site,homology
R12835	T25815	T25813	arg1Of	site,phosphatase-2
R12836	T25815	T25814	arg1Of	site,binding
R12837	T25815	T25816	arg1Of	site,of
R12838	T25815	T25831	arg1Of	site,","
R12839	T25817	T25816	arg2Of	gp130,of
R12840	T25817	T25818	arg1Of	gp130,(
R12841	T25714	T25708	arg1Of	and,the
R12842	T25715	T25714	arg2Of	type,and
R12843	T25823	T25818	arg2Of	subunit,(
R12844	T25823	T25819	arg1Of	subunit,the
R12845	T25823	T25820	arg1Of	subunit,transmembrane
R12846	T25823	T25821	arg1Of	subunit,glycoprotein
R12847	T25823	T25822	arg1Of	subunit,β
R12848	T25823	T25824	arg1Of	subunit,of
R12849	T25715	T25716	arg1Of	type,III
R12850	T25718	T25717	arg2Of	of,and
R12851	T25829	T25824	arg2Of	receptor,of
R12852	T25829	T25825	arg1Of	receptor,the
R12853	T25829	T25826	arg1Of	receptor,IL-6
R12854	T25829	T25827	arg1Of	receptor,family
R12855	T25829	T25828	arg1Of	receptor,cytokine
R12856	T25830	T25818	arg3Of	),(
R12857	T25831	T25810	arg1Of	",",the
R12858	T25831	T25835	arg1Of	",",was
R12859	T25831	T25836	arg2Of	",",mutated
R12860	T25832	T25831	arg2Of	tyrosine,","
R12861	T25832	T25833	arg1Of	tyrosine,759
R12862	T25836	T25808	arg1Of	mutated,in
R12863	T25836	T25834	arg1Of	mutated,","
R12864	T25836	T25835	arg2Of	mutated,was
R12865	T25836	T25837	arg1Of	mutated,to
R12866	T25838	T25837	arg2Of	phenylalanine,to
R12867	T25838	T25839	arg1Of	phenylalanine,[
R12868	T25719	T25718	arg2Of	HLA-DR,of
R12869	T25840	T25839	arg2Of	39,[
R12870	T25841	T25839	arg3Of	],[
R12871	T25719	T25720	arg1Of	HLA-DR,[
R12872	T25721	T25720	arg2Of	31,[
R12873	T25845	T25842	arg2Of	mice,In
R12874	T25845	T25843	arg1Of	mice,the
R12875	T25845	T25844	arg1Of	mice,gp130F759/F759
R12876	T25722	T25720	arg3Of	],[
R12877	T25724	T25723	arg1Of	recently,More
R12878	T25848	T25847	arg1Of	cells,T
R12879	T25848	T25849	arg1Of	cells,","
R12880	T25849	T25856	arg1Of	",",are
R12881	T25849	T25858	arg2Of	",",activated
R12882	T25849	T25860	arg1Of	",",resistant
R12883	T25727	T25726	arg1Of	levels,high
R12884	T25854	T25849	arg2Of	subset,","
R12885	T25854	T25850	arg1Of	subset,particularly
R12886	T25854	T25851	arg1Of	subset,the
R12887	T25854	T25852	arg1Of	subset,CD4+
R12888	T25854	T25853	arg1Of	subset,T-cell
R12889	T25727	T25728	arg1Of	levels,of
R12890	T25858	T25859	arg1Of	activated,and
R12891	T25859	T25842	arg1Of	and,In
R12892	T25859	T25846	arg1Of	and,","
R12893	T25859	T25855	arg1Of	and,","
R12894	T25859	T25856	arg2Of	and,are
R12895	T25859	T25857	arg1Of	and,chronically
R12896	T25859	T25865	arg1Of	and,through
R12897	T25860	T25859	arg2Of	resistant,and
R12898	T25860	T25861	arg1Of	resistant,to
R12899	T25727	T25731	arg1Of	levels,","
R12900	T25727	T25732	arg2Of	levels,thought
R12901	T25727	T25734	arg1Of	levels,be
R12902	T25864	T25861	arg2Of	death,to
R12903	T25864	T25862	arg1Of	death,activation-induced
R12904	T25864	T25863	arg1Of	death,cell
R12905	T25727	T25735	arg2Of	levels,induced
R12906	T25727	T25740	arg1Of	levels,have
R12907	T25727	T25741	arg1Of	levels,been
R12908	T25868	T25865	arg2Of	activation,through
R12909	T25868	T25866	arg1Of	activation,gp130-mediated
R12910	T25868	T25867	arg1Of	activation,STAT3
R12911	T25727	T25742	arg2Of	levels,detected
R12912	T25730	T25728	arg2Of	STAT3,of
R12913	T25870	T25869	arg1Of	longevity,The
R12914	T25870	T25871	arg1Of	longevity,of
R12915	T25870	T25879	arg1Of	longevity,is
R12916	T25870	T25880	arg2Of	longevity,regulated
R12917	T25873	T25871	arg2Of	signals,of
R12918	T25873	T25872	arg1Of	signals,cytokine
R12919	T25873	T25874	arg2Of	signals,transduced
R12920	T25730	T25729	arg2Of	STAT3,activated
R12921	T25735	T25732	arg3Of	induced,thought
R12922	T25878	T25874	arg1Of	pathway,transduced
R12923	T25878	T25875	arg2Of	pathway,by
R12924	T25878	T25876	arg1Of	pathway,the
R12925	T25878	T25877	arg1Of	pathway,JAK–STAT
R12926	T25880	T25879	arg2Of	regulated,is
R12927	T25735	T25733	arg1Of	induced,to
R12928	T25735	T25734	arg2Of	induced,be
R12929	T25735	T25737	arg1Of	induced,by
R12930	T25885	T25880	arg1Of	proteins,regulated
R12931	T25885	T25881	arg2Of	proteins,by
R12932	T25885	T25882	arg1Of	proteins,the
R12933	T25885	T25883	arg1Of	proteins,SOCS
R12934	T25885	T25884	arg1Of	proteins,family
R12935	T25885	T25886	arg1Of	proteins,[
R12936	T25887	T25886	arg2Of	7,[
R12937	T25888	T25886	arg3Of	],[
R12938	T25737	T25736	arg1Of	by,mainly
R12939	T25889	T25890	arg1Of	We,found
R12940	T25738	T25737	arg2Of	IL-6,by
R12941	T25894	T25892	arg1Of	cells,CD4+
R12942	T25894	T25893	arg1Of	cells,T
R12943	T25894	T25895	arg1Of	cells,from
R12944	T25894	T25900	arg1Of	cells,expressed
R12945	T25742	T25739	arg1Of	detected,","
R12946	T25896	T25895	arg2Of	patients,from
R12947	T25896	T25897	arg1Of	patients,with
R12948	T25899	T25897	arg2Of	RA,with
R12949	T25899	T25898	arg1Of	RA,active
R12950	T25900	T25890	arg2Of	expressed,found
R12951	T25900	T25891	arg1Of	expressed,that
R12952	T25900	T25911	arg1Of	expressed,","
R12953	T25900	T25912	arg1Of	expressed,compared
R12954	T25902	T25901	arg1Of	levels,higher
R12955	T25902	T25903	arg1Of	levels,of
R12956	T25902	T25906	arg1Of	levels,but
R12957	T25904	T25903	arg2Of	SOCS1,of
R12958	T25742	T25740	arg2Of	detected,have
R12959	T25742	T25741	arg2Of	detected,been
R12960	T25906	T25900	arg2Of	but,expressed
R12961	T25906	T25905	arg1Of	but,","
R12962	T25908	T25906	arg2Of	levels,but
R12963	T25908	T25907	arg1Of	levels,lower
R12964	T25908	T25909	arg1Of	levels,of
R12965	T25910	T25909	arg2Of	SOCS3,of
R12966	T25742	T25743	arg1Of	detected,in
R12967	T25742	T25747	arg1Of	detected,and
R12968	T25745	T25743	arg2Of	ST,in
R12969	T25913	T25912	arg2Of	with,compared
R12970	T25917	T25913	arg2Of	cells,with
R12971	T25917	T25914	arg1Of	cells,normal
R12972	T25917	T25915	arg1Of	cells,CD4+
R12973	T25745	T25744	arg1Of	ST,the
R12974	T25917	T25916	arg1Of	cells,T
R12975	T25747	T25724	arg1Of	and,recently
R12976	T25918	T25919	arg1Of	SOCS1,prevents
R12977	T25919	T25923	arg1Of	prevents,by
R12978	T25919	T25929	arg1Of	prevents,and
R12979	T25920	T25919	arg2Of	activation,prevents
R12980	T25920	T25921	arg1Of	activation,of
R12981	T25747	T25725	arg1Of	and,","
R12982	T25747	T25746	arg1Of	and,","
R12983	T25922	T25921	arg2Of	JAK,of
R12984	T25749	T25748	arg1Of	activation,STAT3
R12985	T25925	T25923	arg2Of	binding,by
R12986	T25925	T25924	arg1Of	binding,directly
R12987	T25925	T25926	arg1Of	binding,to
R12988	T25749	T25750	arg1Of	activation,has
R12989	T25927	T25926	arg2Of	JAK,to
R12990	T25749	T25751	arg1Of	activation,been
R12991	T25929	T25928	arg1Of	and,","
R12992	T25749	T25752	arg2Of	activation,shown
R12993	T25930	T25931	arg1Of	SOCS3,inhibits
R12994	T25930	T25937	arg1Of	SOCS3,binding
R12995	T25749	T25754	arg1Of	activation,be
R12996	T25931	T25929	arg2Of	inhibits,and
R12997	T25931	T25936	arg1Of	inhibits,by
R12998	T25749	T25755	arg2Of	activation,involved
R12999	T25933	T25931	arg2Of	action,inhibits
R13000	T25933	T25932	arg1Of	action,the
R13001	T25933	T25934	arg1Of	action,of
R13002	T25752	T25747	arg2Of	shown,and
R13003	T25935	T25934	arg2Of	JAK,of
R13004	T25937	T25936	arg2Of	binding,by
R13005	T25937	T25938	arg1Of	binding,to
R13006	T25752	T25750	arg2Of	shown,has
R13007	T25752	T25751	arg2Of	shown,been
R13008	T25755	T25752	arg3Of	involved,shown
R13009	T25943	T25938	arg2Of	domain,to
R13010	T25943	T25939	arg1Of	domain,the
R13011	T25943	T25940	arg1Of	domain,Src
R13012	T25943	T25941	arg1Of	domain,homology
R13013	T25943	T25942	arg1Of	domain,phosphatase-2-binding
R13014	T25943	T25944	arg1Of	domain,of
R13015	T25945	T25944	arg2Of	receptors,of
R13016	T25945	T25947	arg1Of	receptors,as
R13017	T25947	T25946	arg1Of	as,such
R13018	T25948	T25947	arg2Of	gp130,as
R13019	T25948	T25949	arg1Of	gp130,[
R13020	T25950	T25949	arg2Of	40,[
R13021	T25951	T25949	arg3Of	],[
R13022	T25952	T25953	arg1Of	SOCS1,and
R13023	T25755	T25753	arg1Of	involved,to
R13024	T25953	T25955	arg1Of	and,are
R13025	T25953	T25956	arg2Of	and,induced
R13026	T25755	T25754	arg2Of	involved,be
R13027	T25954	T25953	arg2Of	SOCS3,and
R13028	T25755	T25756	arg1Of	involved,in
R13029	T25956	T25955	arg2Of	induced,are
R13030	T25956	T25965	arg1Of	induced,","
R13031	T25956	T25966	arg1Of	induced,as
R13032	T25956	T25974	arg1Of	induced,[
R13033	T25759	T25757	arg1Of	proliferation,synovial
R13034	T25959	T25956	arg1Of	cytokines,induced
R13035	T25959	T25957	arg2Of	cytokines,by
R13036	T25959	T25958	arg1Of	cytokines,various
R13037	T25959	T25960	arg1Of	cytokines,","
R13038	T25959	T25961	arg1Of	cytokines,including
R13039	T25962	T25963	arg1Of	IL-6,and
R13040	T25963	T25961	arg2Of	and,including
R13041	T25964	T25963	arg2Of	IL-10,and
R13042	T25759	T25758	arg1Of	proliferation,fibroblast
R13043	T25759	T25760	arg1Of	proliferation,and
R13044	T25760	T25756	arg2Of	and,in
R13045	T25762	T25760	arg2Of	production,and
R13046	T25762	T25761	arg1Of	production,IL-6
R13047	T25762	T25763	arg1Of	production,[
R13048	T25764	T25763	arg2Of	37,[
R13049	T25967	T25966	arg2Of	mediators,as
R13050	T25967	T25968	arg1Of	mediators,of
R13051	T25970	T25971	arg1Of	feedback,and
R13052	T25765	T25763	arg3Of	],[
R13053	T25972	T25971	arg2Of	crosstalk,and
R13054	T25768	T25766	arg2Of	regard,In
R13055	T25973	T25968	arg2Of	inhibition,of
R13056	T25973	T25969	arg1Of	inhibition,negative
R13057	T25973	T25970	arg1Of	inhibition,feedback
R13058	T25973	T25972	arg1Of	inhibition,crosstalk
R13059	T25975	T25974	arg2Of	7,[
R13060	T25976	T25974	arg3Of	],[
R13061	T25978	T25977	arg1Of	studies,Recent
R13062	T25978	T25979	arg1Of	studies,with
R13063	T25978	T25985	arg1Of	studies,revealed
R13064	T25980	T25979	arg2Of	mice,with
R13065	T25980	T25981	arg1Of	mice,lacking
R13066	T25982	T25983	arg1Of	SOCS3,or
R13067	T25983	T25981	arg2Of	or,lacking
R13068	T25984	T25983	arg2Of	SOCS1,or
R13069	T25768	T25767	arg1Of	regard,this
R13070	T25770	T25771	arg1Of	STAT3,is
R13071	T25987	T25988	arg1Of	SOCS3,is
R13072	T25988	T25985	arg2Of	is,revealed
R13073	T25988	T25986	arg1Of	is,that
R13074	T25770	T25772	arg1Of	STAT3,critical
R13075	T25991	T25988	arg2Of	regulator,is
R13076	T25991	T25989	arg1Of	regulator,a
R13077	T25991	T25990	arg1Of	regulator,negative
R13078	T25771	T25766	arg1Of	is,In
R13079	T25991	T25992	arg1Of	regulator,of
R13080	T25991	T25997	arg1Of	regulator,of
R13081	T25771	T25769	arg1Of	is,","
R13082	T25992	T25995	arg1Of	of,but
R13083	T25771	T25783	arg1Of	is,[
R13084	T25994	T25992	arg2Of	signaling,of
R13085	T25994	T25993	arg1Of	signaling,IL-6
R13086	T25772	T25771	arg2Of	critical,is
R13087	T25997	T25995	arg2Of	of,but
R13088	T25997	T25996	arg1Of	of,not
R13089	T25772	T25773	arg1Of	critical,in
R13090	T25999	T25997	arg2Of	signaling,of
R13091	T26064	T26061	arg2Of	action,and
R13092	T25999	T25998	arg1Of	signaling,IL-10
R13093	T26000	T26001	arg1Of	Studies,of
R13094	T26000	T26005	arg1Of	Studies,have
R13095	T26000	T26006	arg1Of	Studies,shown
R13096	T26004	T26001	arg2Of	mice,of
R13097	T26004	T26002	arg1Of	mice,conditional
R13098	T26004	T26003	arg1Of	mice,SOCS3-deficient
R13099	T26006	T26005	arg2Of	shown,have
R13100	T26064	T26062	arg1Of	action,the
R13101	T26064	T26063	arg1Of	action,immunoregulatory
R13102	T26064	T26065	arg1Of	action,of
R13103	T26009	T26008	arg1Of	deficiency,SOCS3
R13104	T26009	T26011	arg1Of	deficiency,but
R13105	T26064	T26067	arg1Of	action,in
R13106	T26011	T26010	arg1Of	but,","
R13107	T26011	T26012	arg1Of	but,not
R13108	T26011	T26016	arg1Of	but,results
R13109	T26066	T26065	arg2Of	IL-10,of
R13110	T26014	T26011	arg2Of	deficiency,but
R13111	T26014	T26013	arg1Of	deficiency,SOCS1
R13112	T26016	T26006	arg2Of	results,shown
R13113	T26016	T26007	arg1Of	results,that
R13114	T26016	T26015	arg1Of	results,","
R13115	T26016	T26017	arg1Of	results,in
R13116	T26068	T26067	arg2Of	macrophages,in
R13117	T26019	T26017	arg2Of	activation,in
R13118	T26019	T26018	arg1Of	activation,sustained
R13119	T26019	T26020	arg1Of	activation,of
R13120	T26019	T26022	arg1Of	activation,in
R13121	T26021	T26020	arg2Of	STAT3,of
R13122	T26023	T26022	arg2Of	response,in
R13123	T26023	T26024	arg1Of	response,to
R13124	T26068	T26069	arg1Of	macrophages,[
R13125	T26025	T26024	arg2Of	IL-6,to
R13126	T26025	T26026	arg1Of	IL-6,[
R13127	T26070	T26069	arg2Of	41,[
R13128	T26027	T26026	arg2Of	"8,41",[
R13129	T26028	T26026	arg3Of	],[
R13130	T26071	T26069	arg3Of	],[
R13131	T26030	T26029	arg1Of	analysis,The
R13132	T26030	T26031	arg1Of	analysis,of
R13133	T26030	T26034	arg1Of	analysis,has
R13134	T26030	T26035	arg1Of	analysis,indicated
R13135	T26033	T26031	arg2Of	macrophages,of
R13136	T26033	T26032	arg1Of	macrophages,SOCS3-deficient
R13137	T26074	T26072	arg2Of	contrary,On
R13138	T26035	T26034	arg2Of	indicated,has
R13139	T26037	T26038	arg1Of	SOCS3,is
R13140	T26038	T26035	arg2Of	is,indicated
R13141	T26038	T26036	arg1Of	is,that
R13142	T26074	T26073	arg1Of	contrary,the
R13143	T26041	T26038	arg2Of	inhibitor,is
R13144	T26041	T26039	arg1Of	inhibitor,a
R13145	T26041	T26040	arg1Of	inhibitor,crucial
R13146	T26041	T26042	arg1Of	inhibitor,of
R13147	T26076	T26077	arg1Of	SOCS1,was
R13148	T26076	T26078	arg2Of	SOCS1,found
R13149	T26046	T26042	arg2Of	response,of
R13150	T26046	T26043	arg1Of	response,the
R13151	T26046	T26044	arg1Of	response,IL-6-induced
R13152	T26046	T26045	arg1Of	response,transcriptional
R13153	T26046	T26047	arg1Of	response,[
R13154	T26048	T26047	arg2Of	42,[
R13155	T26076	T26081	arg1Of	SOCS1,inhibit
R13156	T26049	T26047	arg3Of	],[
R13157	T26078	T26072	arg1Of	found,On
R13158	T26052	T26053	arg1Of	SOCS3,is
R13159	T26052	T26054	arg1Of	SOCS3,dispensable
R13160	T26053	T26050	arg1Of	is,However
R13161	T26053	T26051	arg1Of	is,","
R13162	T26054	T26053	arg2Of	dispensable,is
R13163	T26054	T26055	arg1Of	dispensable,for
R13164	T26078	T26075	arg1Of	found,","
R13165	T26078	T26077	arg2Of	found,was
R13166	T26081	T26078	arg3Of	inhibit,found
R13167	T26060	T26057	arg1Of	inhibition,the
R13168	T26060	T26058	arg1Of	inhibition,negative
R13169	T26060	T26059	arg1Of	inhibition,feedback
R13170	T26060	T26061	arg1Of	inhibition,and
R13171	T26061	T26055	arg2Of	and,for
R13172	T26061	T26056	arg1Of	and,both
R13173	T26081	T26079	arg1Of	inhibit,to
R13174	T26081	T26080	arg1Of	inhibit,directly
R13175	T26083	T26081	arg2Of	signaling,inhibit
R13176	T26083	T26082	arg1Of	signaling,IL-10-mediated
R13177	T26083	T26084	arg1Of	signaling,[
R13178	T26085	T26084	arg2Of	43,[
R13179	T26161	T26160	arg2Of	IFN-γ,of
R13180	T26162	T26168	arg1Of	in,and
R13181	T26086	T26084	arg3Of	],[
R13182	T26164	T26162	arg2Of	presence,in
R13183	T26164	T26163	arg1Of	presence,the
R13184	T26164	T26165	arg1Of	presence,of
R13185	T26089	T26087	arg2Of	expression,Increased
R13186	T26166	T26165	arg2Of	IL-10,of
R13187	T26168	T26167	arg1Of	and,","
R13188	T26169	T26168	arg2Of	because,and
R13189	T26170	T26171	arg1Of	IFN-γ,has
R13190	T26170	T26172	arg1Of	IFN-γ,been
R13191	T26170	T26173	arg2Of	IFN-γ,known
R13192	T26089	T26088	arg1Of	expression,SOCS1
R13193	T26089	T26090	arg1Of	expression,in
R13194	T26173	T26169	arg2Of	known,because
R13195	T26173	T26171	arg2Of	known,has
R13196	T26173	T26172	arg2Of	known,been
R13197	T26173	T26174	arg1Of	known,as
R13198	T26173	T26180	arg1Of	known,[
R13199	T26089	T26095	arg1Of	expression,may
R13200	T26089	T26097	arg1Of	expression,be
R13201	T26177	T26174	arg2Of	inducer,as
R13202	T26177	T26175	arg1Of	inducer,a
R13203	T26177	T26176	arg1Of	inducer,potent
R13204	T26177	T26178	arg1Of	inducer,of
R13205	T26089	T26098	arg2Of	expression,associated
R13206	T26179	T26178	arg2Of	SOCS1,of
R13207	T26094	T26090	arg2Of	cells,in
R13208	T26181	T26180	arg2Of	32,[
R13209	T26182	T26180	arg3Of	],[
R13210	T26183	T26184	arg1Of	It,is
R13211	T26183	T26185	arg1Of	It,of
R13212	T26185	T26184	arg2Of	of,is
R13213	T26186	T26185	arg2Of	interest,of
R13214	T26186	T26187	arg1Of	interest,in
R13215	T26189	T26187	arg2Of	regard,in
R13216	T26189	T26188	arg1Of	regard,this
R13217	T26189	T26190	modOf	regard,to
R13218	T26191	T26190	arg1Of	indicate,to
R13219	T26094	T26091	arg1Of	cells,RA
R13220	T26094	T26092	arg1Of	cells,CD4+
R13221	T26094	T26093	arg1Of	cells,T
R13222	T26194	T26195	arg1Of	Th1,and
R13223	T26098	T26095	arg2Of	associated,may
R13224	T26196	T26195	arg2Of	Th2,and
R13225	T26197	T26193	arg2Of	cells,polarized
R13226	T26197	T26194	arg1Of	cells,Th1
R13227	T26197	T26196	arg1Of	cells,Th2
R13228	T26197	T26198	arg1Of	cells,express
R13229	T26198	T26191	arg2Of	express,indicate
R13230	T26198	T26192	arg1Of	express,that
R13231	T26198	T26208	arg1Of	express,[
R13232	T26098	T26096	arg1Of	associated,therefore
R13233	T26098	T26097	arg2Of	associated,be
R13234	T26200	T26198	arg2Of	levels,express
R13235	T26200	T26199	arg1Of	levels,high
R13236	T26200	T26201	arg1Of	levels,of
R13237	T26200	T26206	arg1Of	levels,","
R13238	T26200	T26207	arg1Of	levels,respectively
R13239	T26098	T26099	arg1Of	associated,with
R13240	T26202	T26203	arg1Of	SOCS1,and
R13241	T26098	T26107	arg1Of	associated,to
R13242	T26204	T26203	arg2Of	SOCS3,and
R13243	T26098	T26112	arg1Of	associated,and
R13244	T26205	T26201	arg2Of	mRNA,of
R13245	T26205	T26202	arg1Of	mRNA,SOCS1
R13246	T26205	T26204	arg1Of	mRNA,SOCS3
R13247	T26099	T26106	arg1Of	with,and
R13248	T26103	T26099	arg2Of	responsiveness,with
R13249	T26209	T26208	arg2Of	44,[
R13250	T26210	T26208	arg3Of	],[
R13251	T26213	T26211	arg1Of	activation,IL-12-induced
R13252	T26213	T26212	arg1Of	activation,STAT4
R13253	T26213	T26214	arg1Of	activation,is
R13254	T26213	T26215	arg2Of	activation,inhibited
R13255	T26215	T26214	arg2Of	inhibited,is
R13256	T26215	T26223	arg1Of	inhibited,whereas
R13257	T26103	T26100	arg1Of	responsiveness,both
R13258	T26103	T26101	arg1Of	responsiveness,the
R13259	T26218	T26215	arg1Of	induction,inhibited
R13260	T26218	T26216	arg2Of	induction,by
R13261	T26218	T26217	arg1Of	induction,SOCS3
R13262	T26218	T26219	arg1Of	induction,in
R13263	T26221	T26219	arg2Of	cells,in
R13264	T26221	T26220	arg1Of	cells,Th2
R13265	T26103	T26102	arg1Of	responsiveness,impaired
R13266	T26223	T26222	arg1Of	whereas,","
R13267	T26103	T26104	arg1Of	responsiveness,to
R13268	T26105	T26104	arg2Of	IL-10,to
R13269	T26226	T26224	arg1Of	signaling,IL-4-induced
R13270	T26226	T26225	arg1Of	signaling,STAT6
R13271	T26226	T26227	arg1Of	signaling,is
R13272	T26226	T26228	arg2Of	signaling,diminished
R13273	T26228	T26223	arg2Of	diminished,whereas
R13274	T26228	T26227	arg2Of	diminished,is
R13275	T26107	T26106	arg2Of	to,and
R13276	T26231	T26228	arg1Of	induction,diminished
R13277	T26231	T26229	arg2Of	induction,by
R13278	T26231	T26230	arg1Of	induction,SOCS1
R13279	T26231	T26232	arg1Of	induction,in
R13280	T26234	T26232	arg2Of	cells,in
R13281	T26234	T26233	arg1Of	cells,Th1
R13282	T26235	T26236	arg1Of	SOCS1,and
R13283	T26110	T26107	arg2Of	activation,to
R13284	T26236	T26238	arg1Of	and,may
R13285	T26236	T26240	arg1Of	and,have
R13286	T26237	T26236	arg2Of	SOCS3,and
R13287	T26240	T26238	arg2Of	have,may
R13288	T26240	T26239	arg1Of	have,thus
R13289	T26240	T26243	arg1Of	have,as
R13290	T26240	T26261	arg1Of	have,","
R13291	T26240	T26262	arg1Of	have,respectively
R13292	T26242	T26240	arg2Of	roles,have
R13293	T26242	T26241	arg1Of	roles,important
R13294	T26110	T26108	arg1Of	activation,IL-10-mediated
R13295	T26244	T26245	arg1Of	Th1-specific,and
R13296	T26110	T26109	arg1Of	activation,STAT3
R13297	T26245	T26247	arg1Of	and,","
R13298	T26112	T26111	arg1Of	and,","
R13299	T26246	T26245	arg2Of	Th2-specific,and
R13300	T26247	T26250	arg1Of	",",","
R13301	T26249	T26247	arg2Of	exclusive,","
R13302	T26249	T26248	arg1Of	exclusive,mutually
R13303	T26115	T26113	arg1Of	expression,defective
R13304	T26251	T26250	arg2Of	cross-talk,","
R13305	T26252	T26244	arg1Of	repressors,Th1-specific
R13306	T26252	T26246	arg1Of	repressors,Th2-specific
R13307	T26252	T26249	arg1Of	repressors,exclusive
R13308	T26252	T26251	arg1Of	repressors,cross-talk
R13309	T26252	T26253	arg1Of	repressors,of
R13310	T26252	T26256	arg1Of	repressors,and
R13311	T26255	T26253	arg2Of	IL-4–STAT6,of
R13312	T26255	T26254	arg1Of	IL-4–STAT6,the
R13313	T26256	T26243	arg2Of	and,as
R13314	T26115	T26114	arg1Of	expression,SOCS3
R13315	T26115	T26116	arg1Of	expression,may
R13316	T26115	T26117	arg1Of	expression,be
R13317	T26115	T26118	arg1Of	expression,responsible
R13318	T26117	T26112	arg2Of	be,and
R13319	T26117	T26116	arg2Of	be,may
R13320	T26118	T26117	arg2Of	responsible,be
R13321	T26260	T26256	arg2Of	pathways,and
R13322	T26260	T26257	arg1Of	pathways,the
R13323	T26260	T26258	arg1Of	pathways,IL-12–STAT4
R13324	T26260	T26259	arg1Of	pathways,signaling
R13325	T26263	T26264	arg1Of	Consistent,with
R13326	T26118	T26119	arg1Of	responsible,for
R13327	T26122	T26119	arg2Of	activation,for
R13328	T26266	T26264	arg2Of	notion,with
R13329	T26266	T26265	arg1Of	notion,this
R13330	T26270	T26268	arg1Of	cells,PB
R13331	T26270	T26269	arg1Of	cells,T
R13332	T26270	T26271	arg1Of	cells,from
R13333	T26122	T26120	arg1Of	activation,persistent
R13334	T26122	T26121	arg1Of	activation,STAT3
R13335	T26122	T26123	arg1Of	activation,in
R13336	T26270	T26277	arg1Of	cells,express
R13337	T26123	T26125	arg1Of	in,to
R13338	T26272	T26271	arg2Of	patients,from
R13339	T26272	T26273	arg1Of	patients,with
R13340	T26124	T26123	arg2Of	response,in
R13341	T26275	T26273	arg2Of	diseases,with
R13342	T26275	T26274	arg1Of	diseases,allergic
R13343	T26127	T26123	arg3Of	IL-6,in
R13344	T26277	T26276	arg1Of	express,significantly
R13345	T26277	T26284	arg1Of	express,and
R13346	T26279	T26277	arg2Of	levels,express
R13347	T26279	T26278	arg1Of	levels,high
R13348	T26279	T26280	arg1Of	levels,of
R13349	T26127	T26126	arg1Of	IL-6,serum
R13350	T26282	T26280	arg2Of	transcripts,of
R13351	T26282	T26281	arg1Of	transcripts,SOCS3
R13352	T26128	T26129	arg1Of	There,is
R13353	T26284	T26263	arg1Of	and,Consistent
R13354	T26284	T26267	arg1Of	and,","
R13355	T26284	T26283	arg1Of	and,","
R13356	T26131	T26129	arg2Of	possibility,is
R13357	T26287	T26285	arg1Of	expression,the
R13358	T26287	T26286	arg1Of	expression,SOCS3
R13359	T26287	T26288	arg1Of	expression,correlates
R13360	T26288	T26284	arg2Of	correlates,and
R13361	T26288	T26289	arg1Of	correlates,well
R13362	T26288	T26290	arg1Of	correlates,with
R13363	T26293	T26291	arg1Of	levels,serum
R13364	T26293	T26292	arg1Of	levels,IgE
R13365	T26293	T26294	arg1Of	levels,and
R13366	T26294	T26290	arg2Of	and,with
R13367	T26131	T26130	arg1Of	possibility,a
R13368	T26296	T26294	arg2Of	pathology,and
R13369	T26296	T26295	arg1Of	pathology,disease
R13370	T26296	T26297	arg1Of	pathology,[
R13371	T26134	T26133	arg1Of	induction,SOCS1
R13372	T26298	T26297	arg2Of	45,[
R13373	T26299	T26297	arg3Of	],[
R13374	T26302	T26300	arg1Of	expression,Higher
R13375	T26302	T26301	arg1Of	expression,SOCS1
R13376	T26302	T26303	arg1Of	expression,with
R13377	T26302	T26307	arg1Of	expression,in
R13378	T26302	T26315	arg1Of	expression,","
R13379	T26302	T26316	arg1Of	expression,compared
R13380	T26302	T26321	arg1Of	expression,is
R13381	T26302	T26324	arg1Of	expression,consistent
R13382	T26134	T26135	arg1Of	induction,may
R13383	T26306	T26303	arg2Of	expression,with
R13384	T26306	T26304	arg1Of	expression,lower
R13385	T26306	T26305	arg1Of	expression,SOCS3
R13386	T26134	T26136	arg1Of	induction,be
R13387	T26134	T26137	arg2Of	induction,associated
R13388	T26137	T26131	arg2Of	associated,possibility
R13389	T26311	T26307	arg2Of	cells,in
R13390	T26311	T26308	arg1Of	cells,PB
R13391	T26311	T26309	arg1Of	cells,CD4+
R13392	T26311	T26310	arg1Of	cells,T
R13393	T26311	T26312	arg1Of	cells,from
R13394	T26314	T26312	arg2Of	patients,from
R13395	T26314	T26313	arg1Of	patients,RA
R13396	T26137	T26132	arg1Of	associated,that
R13397	T26317	T26316	arg2Of	with,compared
R13398	T26137	T26135	arg2Of	associated,may
R13399	T26137	T26136	arg2Of	associated,be
R13400	T26319	T26317	arg2Of	controls,with
R13401	T26319	T26318	arg1Of	controls,healthy
R13402	T26137	T26138	arg1Of	associated,with
R13403	T26321	T26320	arg1Of	is,","
R13404	T26321	T26322	arg1Of	is,therefore
R13405	T26321	T26333	arg1Of	is,","
R13406	T26321	T26334	arg1Of	is,as
R13407	T26137	T26148	arg1Of	associated,","
R13408	T26324	T26321	arg2Of	consistent,is
R13409	T26324	T26323	arg1Of	consistent,probably
R13410	T26324	T26325	arg1Of	consistent,with
R13411	T26137	T26149	arg1Of	associated,because
R13412	T26328	T26325	arg2Of	bias,with
R13413	T26328	T26326	arg1Of	bias,their
R13414	T26328	T26327	arg1Of	bias,systemic
R13415	T26328	T26329	arg1Of	bias,towards
R13416	T26140	T26138	arg2Of	ability,with
R13417	T26332	T26329	arg2Of	phenotype,towards
R13418	T26332	T26330	arg1Of	phenotype,a
R13419	T26332	T26331	arg1Of	phenotype,Th1
R13420	T26140	T26139	arg1Of	ability,the
R13421	T26140	T26141	arg1Of	ability,of
R13422	T26338	T26334	arg2Of	demonstrated,as
R13423	T26338	T26335	arg2Of	demonstrated,has
R13424	T26338	T26336	arg1Of	demonstrated,previously
R13425	T26338	T26337	arg2Of	demonstrated,been
R13426	T26338	T26339	arg1Of	demonstrated,[
R13427	T26140	T26145	modOf	ability,to
R13428	T26340	T26339	arg2Of	46-49,[
R13429	T26144	T26141	arg2Of	cells,of
R13430	T26341	T26339	arg3Of	],[
R13431	T26144	T26142	arg1Of	cells,CD4+
R13432	T26144	T26143	arg1Of	cells,T
R13433	T26146	T26145	arg1Of	produce,to
R13434	T26147	T26146	arg2Of	IFN-γ,produce
R13435	T26152	T26150	arg1Of	cells,CD4+
R13436	T26152	T26151	arg1Of	cells,T
R13437	T26152	T26153	arg1Of	cells,from
R13438	T26152	T26156	arg1Of	cells,could
R13439	T26152	T26157	arg1Of	cells,produce
R13440	T26155	T26153	arg2Of	RA,from
R13441	T26155	T26154	arg1Of	RA,active
R13442	T26157	T26149	arg2Of	produce,because
R13443	T26157	T26156	arg2Of	produce,could
R13444	T26157	T26162	arg1Of	produce,in
R13445	T26157	T26169	arg1Of	produce,because
R13446	T26159	T26157	arg2Of	levels,produce
R13447	T26159	T26158	arg1Of	levels,high
R13448	T26159	T26160	arg1Of	levels,of

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T23331	6574-6579	Antecedent	denotes	IL-10
T23330	6564-6569	Antecedent	denotes	IFN-γ
T23329	6712-6726	Anaphor	denotes	both cytokines
T23328	5253-5257	Antecedent	denotes	IL-6
T23327	5289-5295	Anaphor	denotes	factor
T23326	4975-4987	Antecedent	denotes	oncostatin M
T23325	4943-4969	Antecedent	denotes	leukemia inhibitory factor
T23324	4936-4941	Antecedent	denotes	IL-11
T23323	4930-4934	Antecedent	denotes	IL-6
T23322	4899-4923	Anaphor	denotes	IL-6 family of cytokines
T23321	4899-4923	Antecedent	denotes	IL-6 family of cytokines
T23320	4863-4885	Anaphor	denotes	a variety of cytokines
T23319	4244-4292	Antecedent	denotes	granulocyte–macrophage colony-stimulating factor
T23318	4234-4238	Antecedent	denotes	IL-1
T23317	4227-4232	Antecedent	denotes	TNF-α
T23316	4186-4218	Anaphor	denotes	proinflammatory cytokine stimuli
T23338	8889-8894	Antecedent	denotes	IL-10
T23337	8880-8884	Antecedent	denotes	IL-6
T23336	8851-8868	Anaphor	denotes	various cytokines
T23335	8808-8813	Antecedent	denotes	gp130
T23334	8790-8799	Anaphor	denotes	receptors
T23333	7251-7255	Antecedent	denotes	IL-6
T23332	7286-7292	Anaphor	denotes	factor
R11365	T23316	T23317	boundBy	proinflammatory cytokine stimuli,TNF-α
R11366	T23316	T23318	boundBy	proinflammatory cytokine stimuli,IL-1
R11367	T23316	T23319	boundBy	proinflammatory cytokine stimuli,granulocyte–macrophage colony-stimulating factor
R11368	T23320	T23321	boundBy	a variety of cytokines,IL-6 family of cytokines
R11369	T23321	T23323	boundBy	IL-6 family of cytokines,IL-6
R11370	T23321	T23324	boundBy	IL-6 family of cytokines,IL-11
R11371	T23321	T23325	boundBy	IL-6 family of cytokines,leukemia inhibitory factor
R11372	T23321	T23326	boundBy	IL-6 family of cytokines,oncostatin M
R11373	T23327	T23328	boundBy	factor,IL-6
R11374	T23329	T23330	boundBy	both cytokines,IFN-γ
R11375	T23329	T23331	boundBy	both cytokines,IL-10
R11376	T23332	T23333	boundBy	factor,IL-6
R11377	T23334	T23335	boundBy	receptors,gp130
R11378	T23336	T23337	boundBy	various cytokines,IL-6
R11379	T23336	T23338	boundBy	various cytokines,IL-10

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T23526	10124-10129	Protein	denotes	IFN-γ
T23525	10105-10110	Protein	denotes	IL-10
T23524	10080-10085	Protein	denotes	IFN-γ
T23523	10023-10026	Protein	denotes	CD4
T23522	10008-10013	Protein	denotes	IFN-γ
T23521	9984-9987	Protein	denotes	CD4
T23520	9930-9935	Protein	denotes	SOCS1
T23519	9896-9900	Protein	denotes	IL-6
T23518	9858-9863	Protein	denotes	STAT3
T23517	9807-9812	Protein	denotes	SOCS3
T23516	9775-9780	Protein	denotes	STAT3
T23515	9760-9765	Protein	denotes	IL-10
T23514	9747-9752	Protein	denotes	IL-10
T23513	9665-9668	Protein	denotes	CD4
T23512	9642-9647	Protein	denotes	SOCS1
T23511	9601-9606	Protein	denotes	IL-10
T23510	9565-9570	Protein	denotes	SOCS1
T23509	9521-9526	Protein	denotes	IL-10
T23508	9423-9428	Protein	denotes	SOCS3
T23507	9370-9374	Protein	denotes	IL-6
T23506	9334-9339	Protein	denotes	SOCS3
T23505	9287-9292	Protein	denotes	SOCS3
T23504	9258-9262	Protein	denotes	IL-6
T23503	9237-9242	Protein	denotes	STAT3
T23502	9184-9189	Protein	denotes	SOCS1
T23501	9158-9163	Protein	denotes	SOCS3
T23500	9121-9126	Protein	denotes	SOCS3
T23499	9081-9086	Protein	denotes	IL-10
T23498	9055-9059	Protein	denotes	IL-6
T23497	9022-9027	Protein	denotes	SOCS3
T23496	9002-9007	Protein	denotes	SOCS1
T23495	8993-8998	Protein	denotes	SOCS3
T23494	8889-8894	Protein	denotes	IL-10
T23493	8880-8884	Protein	denotes	IL-6
T23492	8830-8835	Protein	denotes	SOCS3
T23491	8820-8825	Protein	denotes	SOCS1
T23490	8808-8813	Protein	denotes	gp130
T23489	8694-8699	Protein	denotes	SOCS3
T23488	8629-8634	Protein	denotes	SOCS1
T23487	8615-8618	Protein	denotes	CD4
T23486	8587-8592	Protein	denotes	SOCS3
T23485	8560-8565	Protein	denotes	SOCS1
T23484	8491-8494	Protein	denotes	CD4
T23483	8344-8349	Protein	denotes	STAT3
T23482	8329-8334	Protein	denotes	gp130
T23481	8228-8231	Protein	denotes	CD4
T23480	8181-8186	Protein	denotes	gp130
T23479	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T23478	8038-8043	Protein	denotes	gp130
T23477	7961-7966	Protein	denotes	gp130
T23476	7865-7870	Protein	denotes	STAT3
T23475	7719-7724	Protein	denotes	STAT3
T23474	7681-7685	Protein	denotes	IL-6
T23473	7593-7598	Protein	denotes	STAT3
T23472	7553-7557	Protein	denotes	IL-6
T23471	7514-7519	Protein	denotes	STAT3
T23470	7445-7453	Protein	denotes	type III
T23469	7416-7440	Protein	denotes	Fc gamma receptor type I
T23468	7269-7274	Protein	denotes	STAT3
T23467	7251-7255	Protein	denotes	IL-6
T23466	7158-7163	Protein	denotes	STAT3
T23465	7087-7092	Protein	denotes	STAT3
T23464	6928-6933	Protein	denotes	IL-10
T23463	6874-6879	Protein	denotes	IL-10
T23462	6832-6837	Protein	denotes	SOCS1
T23461	6815-6820	Protein	denotes	IFN-γ
T23460	6794-6799	Protein	denotes	STAT3
T23459	6761-6766	Protein	denotes	IL-10
T23458	6650-6655	Protein	denotes	IL-10
T23457	6592-6595	Protein	denotes	CD4
T23456	6574-6579	Protein	denotes	IL-10
T23455	6564-6569	Protein	denotes	IFN-γ
T23454	6528-6532	Protein	denotes	IL-6
T23453	6487-6492	Protein	denotes	TNF-α
T23452	6477-6482	Protein	denotes	IL-1β
T23451	6431-6434	Protein	denotes	CD4
T23450	6411-6416	Protein	denotes	IFN-γ
T23449	6396-6401	Protein	denotes	IL-10
T23448	6178-6182	Protein	denotes	IL-6
T23447	6104-6109	Protein	denotes	IL-10
T23446	6088-6091	Protein	denotes	CD4
T23445	6020-6025	Protein	denotes	STAT3
T23444	6006-6011	Protein	denotes	IL-10
T23443	5938-5941	Protein	denotes	CD4
T23442	5926-5931	Protein	denotes	IL-10
T23441	5856-5859	Protein	denotes	CD4
T23440	5838-5843	Protein	denotes	IL-10
T23439	5773-5778	Protein	denotes	IL-10
T23438	5747-5750	Protein	denotes	CD4
T23437	5697-5702	Protein	denotes	STAT3
T23436	5657-5661	Protein	denotes	IL-6
T23435	5566-5569	Protein	denotes	CD4
T23434	5537-5542	Protein	denotes	IL-10
T23433	5498-5503	Protein	denotes	STAT3
T23432	5446-5450	Protein	denotes	IL-6
T23423	4936-4941	Protein	denotes	IL-11
T23422	4930-4934	Protein	denotes	IL-6
T23421	4841-4846	Protein	denotes	STAT3
T23420	4810-4813	Protein	denotes	CD4
T23419	4705-4710	Protein	denotes	STAT3
T23418	4687-4692	Protein	denotes	STAT3
T23417	4672-4677	Protein	denotes	IL-10
T23416	4490-4495	Protein	denotes	IL-10
T23415	4448-4455	Protein	denotes	IL-10R1
T23414	4417-4422	Protein	denotes	STAT3
T23413	4401-4406	Protein	denotes	IL-10
T23412	4362-4367	Protein	denotes	IL-10
T23411	4346-4349	Protein	denotes	CD4
T23410	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T23409	4234-4238	Protein	denotes	IL-1
T23408	4227-4232	Protein	denotes	TNF-α
T23407	4159-4166	Protein	denotes	IL-10R1
T23406	4109-4114	Protein	denotes	IL-10
T23405	3889-3894	Protein	denotes	IFN-γ
T23404	3855-3859	Protein	denotes	Jak1
T23403	3841-3846	Protein	denotes	IL-10
T23402	3818-3825	Protein	denotes	IL-10R1
T23401	3707-3712	Protein	denotes	IL-10
T23400	3625-3630	Protein	denotes	STAT3
T23399	3610-3615	Protein	denotes	IL-10
T23398	3558-3562	Protein	denotes	IL-6
T23397	3548-3553	Protein	denotes	IL-10
T23396	3514-3519	Protein	denotes	STAT3
T23395	3509-3513	Protein	denotes	Jak1
T23394	3490-3494	Protein	denotes	IL-1
T23393	3480-3485	Protein	denotes	TNF-α
T23392	3177-3182	Protein	denotes	IL-10
T23391	2968-2972	Protein	denotes	IL-2
T23390	2958-2963	Protein	denotes	IFN-γ
T23389	2921-2925	Protein	denotes	CD28
T23388	2901-2906	Protein	denotes	IL-10
T23387	2869-2872	Protein	denotes	CD4
T23386	2754-2758	Protein	denotes	CD28
T23385	2664-2669	Protein	denotes	IL-10
T23384	2595-2599	Protein	denotes	CD86
T23383	2586-2590	Protein	denotes	CD80
T23382	2286-2289	Protein	denotes	CD4
T23381	2257-2262	Protein	denotes	IL-10
T23380	2240-2245	Protein	denotes	SOCS1
T23379	2214-2219	Protein	denotes	STAT3
T23378	2166-2171	Protein	denotes	STAT3
T23377	2150-2155	Protein	denotes	IL-10
T23376	2040-2045	Protein	denotes	IL-10
T23375	1982-1985	Protein	denotes	CD4
T23374	1939-1942	Protein	denotes	CD4
T23373	1895-1900	Protein	denotes	SOCS3
T23372	1861-1866	Protein	denotes	SOCS1
T23371	1823-1826	Protein	denotes	CD4
T23370	1802-1807	Protein	denotes	IFN-γ
T23369	1782-1787	Protein	denotes	IL-10
T23368	1751-1755	Protein	denotes	IL-6
T23367	1723-1726	Protein	denotes	CD4
T23366	1691-1696	Protein	denotes	STAT1
T23365	1677-1682	Protein	denotes	STAT3
T23364	1647-1651	Protein	denotes	IL-6
T23363	1634-1639	Protein	denotes	IL-10
T23362	1579-1584	Protein	denotes	STAT3
T23361	1559-1562	Protein	denotes	CD4
T23360	1523-1526	Protein	denotes	CD4
T23359	1497-1502	Protein	denotes	STAT3
T23358	1455-1460	Protein	denotes	IL-10
T23357	1437-1442	Protein	denotes	STAT3
T23356	1401-1408	Protein	denotes	IL-10R1
T23355	1368-1371	Protein	denotes	CD4
T23354	1337-1341	Protein	denotes	CD28
T23353	1317-1322	Protein	denotes	IFN-γ
T23352	1273-1278	Protein	denotes	IL-10
T23351	1211-1214	Protein	denotes	CD4
T23350	1046-1050	Protein	denotes	CD28
T23349	995-1000	Protein	denotes	IL-10
T23348	852-857	Protein	denotes	IL-10
T23347	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T23346	661-665	Protein	denotes	CD28
T23345	493-497	Protein	denotes	CD86
T23344	484-488	Protein	denotes	CD80
T23343	465-469	Protein	denotes	CD28
T23342	414-418	Protein	denotes	CD28
T23341	333-336	Protein	denotes	CD4
T23340	101-104	Protein	denotes	CD4
T23339	11-14	Protein	denotes	CD4
T23431	5399-5402	Protein	denotes	CD4
T23430	5368-5373	Protein	denotes	IL-10
T23429	5272-5277	Protein	denotes	STAT3
T23428	5253-5257	Protein	denotes	IL-6
T23427	5055-5059	Protein	denotes	IL-6
T23426	5024-5029	Protein	denotes	IL-10
T23425	4975-4987	Protein	denotes	oncostatin M
T23424	4943-4969	Protein	denotes	leukemia inhibitory factor
T23530	10322-10327	Protein	denotes	IL-12
T23546	10959-10962	Protein	denotes	CD4
T23545	10936-10941	Protein	denotes	SOCS3
T23544	10908-10913	Protein	denotes	SOCS1
T23543	10818-10823	Protein	denotes	SOCS3
T23542	10791-10796	Protein	denotes	SOCS3
T23541	10637-10642	Protein	denotes	STAT4
T23540	10631-10636	Protein	denotes	IL-12
T23539	10617-10622	Protein	denotes	STAT6
T23538	10612-10616	Protein	denotes	IL-4
T23537	10493-10498	Protein	denotes	SOCS3
T23536	10483-10488	Protein	denotes	SOCS1
T23535	10453-10458	Protein	denotes	SOCS1
T23534	10420-10425	Protein	denotes	STAT6
T23533	10407-10411	Protein	denotes	IL-4
T23532	10369-10374	Protein	denotes	SOCS3
T23531	10336-10341	Protein	denotes	STAT4
T23529	10291-10296	Protein	denotes	SOCS3
T23528	10281-10286	Protein	denotes	SOCS1
T23527	10168-10173	Protein	denotes	SOCS1

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T26445	9184-9189	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26434	9055-9059	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26433	8880-8884	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26432	8093-8097	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26431	7681-7685	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26430	7553-7557	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26429	7251-7255	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26428	6528-6532	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26427	6178-6182	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26426	5657-5661	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26425	5446-5450	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26424	5253-5257	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26423	5055-5059	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26422	4930-4934	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26421	4899-4903	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26420	3558-3562	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26419	1751-1755	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26418	1647-1651	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26417	9858-9863	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26416	9775-9780	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26415	9237-9242	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26414	8344-8349	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26413	7865-7870	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26412	7719-7724	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26411	7593-7598	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26410	7514-7519	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26409	7269-7274	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26408	7158-7163	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26407	7087-7092	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26406	6794-6799	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26405	6020-6025	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26404	5697-5702	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26403	5498-5503	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26402	5272-5277	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26401	4841-4846	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26400	4705-4710	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26399	4687-4692	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26398	4417-4422	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26397	3625-3630	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26396	3514-3519	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26395	2214-2219	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26394	2166-2171	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26393	1677-1682	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26392	1579-1584	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26391	1497-1502	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26390	1437-1442	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T26389	1329-1332	http://www.uniprot.org/uniprot/P09693	denotes	CD3
T26388	1329-1332	http://www.uniprot.org/uniprot/P07766	denotes	CD3
T26387	1329-1332	http://www.uniprot.org/uniprot/P04234	denotes	CD3
T26386	1329-1332	http://www.uniprot.org/uniprot/P20963	denotes	CD3
T26385	10124-10129	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26384	10080-10085	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26383	10008-10013	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26382	6815-6820	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26381	6564-6569	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26380	6411-6416	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26379	3889-3894	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26378	2958-2963	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26377	1802-1807	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26376	1317-1322	http://www.uniprot.org/uniprot/P01579	denotes	IFN-γ
T26375	10105-10110	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26374	9760-9765	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26373	9747-9752	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26372	9601-9606	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26371	9521-9526	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26370	9081-9086	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26369	8889-8894	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26368	6928-6933	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26367	6874-6879	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26366	6761-6766	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26365	6650-6655	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26364	6574-6579	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26363	6396-6401	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26362	6104-6109	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26361	6006-6011	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26360	5926-5931	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26359	5838-5843	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26358	5773-5778	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26357	5537-5542	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26356	5368-5373	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26355	5024-5029	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26354	4672-4677	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26353	4490-4495	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26352	4401-4406	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26351	4362-4367	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26350	4109-4114	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26349	3841-3846	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26348	3707-3712	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26347	3610-3615	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26346	3548-3553	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26345	3177-3182	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26344	2901-2906	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26343	2664-2669	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26342	2257-2262	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T26470	10617-10622	http://www.uniprot.org/uniprot/P42226	denotes	STAT6
T26469	10420-10425	http://www.uniprot.org/uniprot/P42226	denotes	STAT6
T26468	10612-10616	http://www.uniprot.org/uniprot/P05112	denotes	IL-4
T26467	10407-10411	http://www.uniprot.org/uniprot/P05112	denotes	IL-4
T26466	10637-10642	http://www.uniprot.org/uniprot/Q14765	denotes	STAT4
T26465	10336-10341	http://www.uniprot.org/uniprot/Q14765	denotes	STAT4
T26464	10631-10636	http://www.uniprot.org/uniprot/P29460	denotes	IL-12
T26463	10322-10327	http://www.uniprot.org/uniprot/P29460	denotes	IL-12
T26462	10631-10636	http://www.uniprot.org/uniprot/P29459	denotes	IL-12
T26461	10322-10327	http://www.uniprot.org/uniprot/P29459	denotes	IL-12
T26460	6477-6482	http://www.uniprot.org/uniprot/P01584	denotes	IL-1β
T26459	6487-6492	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T26458	4227-4232	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T26457	3480-3485	http://www.uniprot.org/uniprot/P01375	denotes	TNF-α
T26456	4227-4230	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T26455	3480-3483	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T26454	2968-2972	http://www.uniprot.org/uniprot/P60568	denotes	IL-2
T26453	10908-10913	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26452	10483-10488	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26451	10453-10458	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26450	10281-10286	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26449	10168-10173	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26448	9930-9935	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26447	9642-9647	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26446	9565-9570	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T24280	2150-2155	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24279	2040-2045	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24278	1782-1787	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24277	1634-1639	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24276	1455-1460	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24275	1273-1278	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24274	995-1000	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24273	852-857	http://www.uniprot.org/uniprot/P22301	denotes	IL-10
T24272	2595-2599	http://www.uniprot.org/uniprot/P42081	denotes	CD86
T24271	493-497	http://www.uniprot.org/uniprot/P42081	denotes	CD86
T24270	2586-2590	http://www.uniprot.org/uniprot/P33681	denotes	CD80
T24269	484-488	http://www.uniprot.org/uniprot/P33681	denotes	CD80
T24268	2921-2925	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24267	2754-2758	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24266	1337-1341	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24265	1046-1050	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24264	661-665	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24263	465-469	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24262	414-418	http://www.uniprot.org/uniprot/P10747	denotes	CD28
T24261	10959-10962	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24260	10023-10026	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24259	9984-9987	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24240	1823-1826	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24239	1723-1726	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24238	1559-1562	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24237	1523-1526	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24236	1368-1371	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24235	1211-1214	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24234	333-336	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24233	101-104	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24232	11-14	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24252	6088-6091	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24251	5938-5941	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24250	5856-5859	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24249	5747-5750	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24248	5566-5569	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24247	5399-5402	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24246	4810-4813	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24245	4346-4349	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24244	2869-2872	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24243	2286-2289	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24242	1982-1985	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24241	1939-1942	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24258	9665-9668	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24257	8615-8618	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24256	8491-8494	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24255	8228-8231	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24254	6592-6595	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T24253	6431-6434	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T26444	9002-9007	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26443	8820-8825	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26442	8629-8634	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26441	8560-8565	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26440	6832-6837	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26439	2240-2245	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26438	1861-1866	http://www.uniprot.org/uniprot/O15524	denotes	SOCS1
T26437	9896-9900	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26436	9370-9374	http://www.uniprot.org/uniprot/P05231	denotes	IL-6
T26435	9258-9262	http://www.uniprot.org/uniprot/P05231	denotes	IL-6

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T22796	10856-10861	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T22795	9890-9895	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T22794	5651-5656	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T22793	5313-5318	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T22792	6224-6229	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T22791	5200-5205	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T22790	7304-7318	http://purl.obolibrary.org/obo/UBERON_0001090	denotes	synovial fluid
T22789	7195-7209	http://purl.obolibrary.org/obo/UBERON_0001090	denotes	synovial fluid
T22788	4045-4060	http://purl.obolibrary.org/obo/UBERON_0001090	denotes	synovial fluids

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T22940	10563-10571	http://purl.obolibrary.org/obo/GO_0085030	denotes	mutually
T22939	9383-9398	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T22938	9246-9262	http://purl.obolibrary.org/obo/GO_0070741	denotes	response to IL-6
T22937	9246-9262	http://purl.obolibrary.org/obo/GO_0071354	denotes	response to IL-6
T22936	8723-8726	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T22935	8685-8688	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T22934	8658-8661	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T22933	8414-8417	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T22932	8315-8320	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T22931	8310-8320	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T22930	8291-8320	http://purl.obolibrary.org/obo/GO_2000109	denotes	activation-induced cell death
T22929	8291-8320	http://purl.obolibrary.org/obo/GO_0071888	denotes	activation-induced cell death
T22928	8808-8813	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T22927	8329-8334	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T22926	8038-8043	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T22925	8808-8813	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T22924	8329-8334	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T22923	8038-8043	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T22922	8808-8813	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T22921	8329-8334	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T22920	8038-8043	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T22919	8758-8769	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T22918	8008-8019	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T22917	7681-7696	http://purl.obolibrary.org/obo/GO_0032675	denotes	IL-6 production
T22916	7681-7696	http://purl.obolibrary.org/obo/GO_0032635	denotes	IL-6 production
T22915	7652-7676	http://purl.obolibrary.org/obo/GO_0048144	denotes	fibroblast proliferation
T22914	7393-7408	http://purl.obolibrary.org/obo/GO_0010467	denotes	gene expression
T22913	7352-7374	http://purl.obolibrary.org/obo/GO_0042117	denotes	activation of monocyte
T22912	7131-7143	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T22911	6800-6820	http://purl.obolibrary.org/obo/GO_1902715	denotes	activation and IFN-γ
T22910	5779-5788	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T22909	5773-5788	http://purl.obolibrary.org/obo/GO_2001179	denotes	IL-10 secretion
T22908	5773-5788	http://purl.obolibrary.org/obo/GO_0072608	denotes	IL-10 secretion
T22907	5200-5217	http://purl.obolibrary.org/obo/GO_0008015	denotes	blood circulation
T22906	7770-7776	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T22905	4993-4999	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T22904	4582-4594	http://purl.obolibrary.org/obo/GO_0009293	denotes	transduction
T22903	4132-4141	http://purl.obolibrary.org/obo/GO_0006810	denotes	transport
T22902	4575-4594	http://purl.obolibrary.org/obo/GO_0007165	denotes	signal transduction
T22901	6026-6043	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T22900	3520-3537	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T22899	3448-3451	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T22898	2499-2514	http://purl.obolibrary.org/obo/GO_0001775	denotes	cell activation
T22897	2497-2514	http://purl.obolibrary.org/obo/GO_1903905	denotes	T-cell activation
T22896	2497-2514	http://purl.obolibrary.org/obo/GO_0050863	denotes	T-cell activation
T22895	2497-2514	http://purl.obolibrary.org/obo/GO_0050798	denotes	T-cell activation
T22894	2497-2514	http://purl.obolibrary.org/obo/GO_0042110	denotes	T-cell activation
T22893	2497-2514	http://purl.obolibrary.org/obo/GO_0051132	denotes	T-cell activation
T22892	3253-3272	http://purl.obolibrary.org/obo/GO_0001816	denotes	cytokine production
T22891	2298-2317	http://purl.obolibrary.org/obo/GO_0001816	denotes	cytokine production
T22890	2293-2317	http://purl.obolibrary.org/obo/GO_0035745	denotes	cell cytokine production
T22889	2293-2317	http://purl.obolibrary.org/obo/GO_0035744	denotes	cell cytokine production
T22888	2293-2317	http://purl.obolibrary.org/obo/GO_0002368	denotes	cell cytokine production
T22887	2293-2317	http://purl.obolibrary.org/obo/GO_0032762	denotes	cell cytokine production
T22886	2293-2317	http://purl.obolibrary.org/obo/GO_0002371	denotes	cell cytokine production
T22885	2293-2317	http://purl.obolibrary.org/obo/GO_0002370	denotes	cell cytokine production
T22884	2291-2317	http://purl.obolibrary.org/obo/GO_0002724	denotes	T-cell cytokine production
T22883	2291-2317	http://purl.obolibrary.org/obo/GO_0002369	denotes	T-cell cytokine production
T22882	6411-6427	http://purl.obolibrary.org/obo/GO_1902714	denotes	IFN-γ inhibition
T22881	1788-1807	http://purl.obolibrary.org/obo/GO_1902714	denotes	inhibition of IFN-γ
T22880	2768-2783	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22879	2220-2235	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22878	1697-1712	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22877	1585-1600	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22876	1478-1493	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22875	1023-1038	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T22874	684-699	http://purl.obolibrary.org/obo/GO_0001913	denotes	T-cell-mediated
T22873	10643-10652	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T22872	10426-10435	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T22871	9616-9625	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T22870	9087-9096	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T22869	9060-9069	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T22868	8388-8395	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T22867	358-365	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T22866	906-928	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T22865	293-305	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T22864	63-78	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune response
T22863	49-69	http://purl.obolibrary.org/obo/GO_0001909	denotes	cell-mediated immune
T22862	49-78	http://purl.obolibrary.org/obo/GO_0002443	denotes	cell-mediated immune response
T22861	49-69	http://purl.obolibrary.org/obo/GO_0002228	denotes	cell-mediated immune
T22860	49-69	http://purl.obolibrary.org/obo/GO_0019724	denotes	cell-mediated immune
T22859	684-699	http://purl.obolibrary.org/obo/GO_0002456	denotes	T-cell-mediated
T22858	49-69	http://purl.obolibrary.org/obo/GO_0002456	denotes	cell-mediated immune
T22857	49-69	http://purl.obolibrary.org/obo/GO_0002449	denotes	cell-mediated immune

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T23694	8049-8062	http://purl.obolibrary.org/obo/GO_0044214	denotes	transmembrane
T23693	8049-8062	http://purl.obolibrary.org/obo/GO_0016021	denotes	transmembrane
T23692	4145-4158	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T23691	3404-3417	http://purl.obolibrary.org/obo/GO_0005576	denotes	extracellular
T23690	793-808	http://purl.obolibrary.org/obo/GO_0009986	denotes	cell-associated
T23689	210-222	http://purl.obolibrary.org/obo/GO_0009986	denotes	cell surface
T23688	10966-10971	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23687	10711-10716	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23686	10476-10481	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23685	10392-10397	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23684	10252-10257	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23683	10030-10035	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23682	9991-9996	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23681	9672-9677	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23680	8622-8627	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23679	8498-8503	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23678	8204-8209	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23677	7222-7227	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23676	6599-6604	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23675	6438-6443	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23674	6095-6100	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23673	5945-5950	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23672	5863-5868	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23671	5754-5759	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23670	5573-5578	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23669	5406-5411	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23668	4817-4822	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23667	4353-4358	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23666	4031-4036	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23647	108-113	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23646	18-23	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23665	3279-3284	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23664	3221-3226	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23663	2876-2881	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23662	1989-1994	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23661	1946-1951	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23660	1830-1835	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23659	1730-1735	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23658	1566-1571	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23657	1530-1535	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23656	1375-1380	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23655	1218-1223	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23654	1160-1165	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23653	1122-1127	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23652	984-989	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23651	626-631	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23650	586-591	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23649	340-345	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T23648	161-166	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T23645	10612-10616	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T23644	10407-10411	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T23643	10631-10636	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T23642	10322-10327	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T23641	8770-8786	http://purl.obolibrary.org/obo/GO_0050682	denotes	2-binding domain
T23640	8758-8779	http://purl.obolibrary.org/obo/GO_0051721	denotes	phosphatase-2-binding
T23639	8723-8726	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T23638	8685-8688	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T23637	8658-8661	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T23636	8414-8417	http://purl.obolibrary.org/obo/GO_0004713	denotes	JAK
T23635	8808-8813	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T23634	8329-8334	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T23633	8038-8043	http://purl.obolibrary.org/obo/GO_0004921	denotes	gp130
T23632	8808-8813	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T23631	8329-8334	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T23630	8038-8043	http://purl.obolibrary.org/obo/GO_0004915	denotes	gp130
T23629	8808-8813	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T23628	8329-8334	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T23627	8038-8043	http://purl.obolibrary.org/obo/GO_0004897	denotes	gp130
T23626	8758-8769	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T23625	8008-8019	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T23624	4975-4987	http://purl.obolibrary.org/obo/GO_0005147	denotes	oncostatin M
T23623	4936-4941	http://purl.obolibrary.org/obo/GO_0005142	denotes	IL-11
T23622	3448-3451	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T23621	3113-3132	http://purl.obolibrary.org/obo/GO_0005125	denotes	cytokine activities
T23620	2968-2972	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T23619	9896-9900	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23618	9370-9374	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23617	9258-9262	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23616	9055-9059	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23615	8880-8884	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23614	8093-8097	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23613	7681-7685	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23612	7553-7557	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23611	7251-7255	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23610	6528-6532	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23609	6178-6182	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23608	5657-5661	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23607	5446-5450	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23606	5253-5257	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23605	5055-5059	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23604	4930-4934	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23603	4899-4903	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23602	3558-3562	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23601	1751-1755	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23600	1647-1651	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T23599	1102-1116	http://purl.obolibrary.org/obo/GO_0019900	denotes	kinase binding
T23598	4234-4238	http://purl.obolibrary.org/obo/GO_0005149	denotes	IL-1
T23597	3490-3494	http://purl.obolibrary.org/obo/GO_0005149	denotes	IL-1
T23596	991-997	http://purl.obolibrary.org/obo/GO_0005149	denotes	1]. IL
T23595	10105-10110	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23594	9760-9765	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23593	9747-9752	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23592	9601-9606	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23591	9521-9526	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23590	9081-9086	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23589	8889-8894	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23588	6928-6933	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23587	6874-6879	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23586	6761-6766	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23585	6650-6655	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23584	6574-6579	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23583	6396-6401	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23582	6104-6109	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23581	6006-6011	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23580	5926-5931	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23579	5838-5843	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23578	5773-5778	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23577	5537-5542	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23576	5368-5373	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23575	5024-5029	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23574	4672-4677	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23573	4490-4495	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23572	4401-4406	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23571	4362-4367	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23570	4109-4114	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23569	3841-3846	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23568	3707-3712	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23567	3610-3615	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23566	3548-3553	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23565	3177-3182	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23564	2901-2906	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23563	2664-2669	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23562	2257-2262	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23561	2150-2155	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23560	2040-2045	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23559	1782-1787	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23558	1634-1639	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23557	1455-1460	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23556	1273-1278	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23555	995-1000	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23554	852-857	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T23553	847-854	http://purl.obolibrary.org/obo/GO_0045519	denotes	23]. IL
T23552	8772-8779	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T23551	8730-8737	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T23550	8674-8681	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T23549	8022-8029	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T23548	1109-1116	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T23547	470-477	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands

sentences

Id	Subject	Object	Predicate	Lexical cue
T22856	10901-11149	Sentence	denotes	Higher SOCS1 expression with lower SOCS3 expression in PB CD4+ T cells from RA patients, compared with healthy controls, is therefore probably consistent with their systemic bias towards a Th1 phenotype, as has previously been demonstrated [46-49].
T22855	10677-10900	Sentence	denotes	Consistent with this notion, PB T cells from patients with allergic diseases significantly express high levels of SOCS3 transcripts, and the SOCS3 expression correlates well with serum IgE levels and disease pathology [45].
T22854	10483-10676	Sentence	denotes	SOCS1 and SOCS3 may thus have important roles as Th1-specific and Th2-specific, mutually exclusive, cross-talk repressors of the IL-4–STAT6 and the IL-12–STAT4 signaling pathways, respectively.
T22853	10322-10482	Sentence	denotes	IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells, whereas IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells.
T22852	10180-10321	Sentence	denotes	It is of interest in this regard to indicate that polarized Th1 and Th2 cells express high levels of SOCS1 and SOCS3 mRNA, respectively [44].
T22851	9902-10179	Sentence	denotes	There is a possibility that SOCS1 induction may be associated with the ability of CD4+ T cells to produce IFN-γ, because CD4+ T cells from active RA could produce high levels of IFN-γ in the presence of IL-10, and because IFN-γ has been known as a potent inducer of SOCS1 [32].
T22850	9632-9901	Sentence	denotes	Increased SOCS1 expression in RA CD4+ T cells may therefore be associated with both the impaired responsiveness to IL-10 and to IL-10-mediated STAT3 activation, and defective SOCS3 expression may be responsible for persistent STAT3 activation in response to serum IL-6.
T22849	9548-9631	Sentence	denotes	On the contrary, SOCS1 was found to directly inhibit IL-10-mediated signaling [43].
T22848	9414-9547	Sentence	denotes	However, SOCS3 is dispensable for both the negative feedback inhibition and the immunoregulatory action of IL-10 in macrophages [41].
T22847	9271-9413	Sentence	denotes	The analysis of SOCS3-deficient macrophages has indicated that SOCS3 is a crucial inhibitor of the IL-6-induced transcriptional response [42].
T22846	9098-9270	Sentence	denotes	Studies of conditional SOCS3-deficient mice have shown that SOCS3 deficiency, but not SOCS1 deficiency, results in sustained activation of STAT3 in response to IL-6 [8,41].
T22845	8960-9097	Sentence	denotes	Recent studies with mice lacking SOCS3 or SOCS1 revealed that SOCS3 is a negative regulator of IL-6 signaling but not of IL-10 signaling.
T22844	8820-8959	Sentence	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7].
T22843	8629-8819	Sentence	denotes	SOCS1 prevents activation of JAK by directly binding to JAK, and SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40].
T22842	8477-8628	Sentence	denotes	We found that CD4+ T cells from patients with active RA expressed higher levels of SOCS1, but lower levels of SOCS3, compared with normal CD4+ T cells.
T22841	8362-8476	Sentence	denotes	The longevity of cytokine signals transduced by the JAK–STAT pathway is regulated by the SOCS family proteins [7].
T22840	8174-8361	Sentence	denotes	In the gp130F759/F759 mice, T cells, particularly the CD4+ T-cell subset, are chronically activated and resistant to activation-induced cell death through gp130-mediated STAT3 activation.
T22839	7821-8173	Sentence	denotes	Furthermore, the significance of persistent STAT3 signaling in Th1-cell-dominated autoimmune arthritis has been suggested by studies of the gp130F759/F759 mice, in which the Src homology phosphatase-2 binding site of gp130 (the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor), tyrosine 759, was mutated to phenylalanine [39].
T22838	7703-7820	Sentence	denotes	In this regard, STAT3 is critical in the survival and expansion of growth factor-dependent synovial fibroblasts [38].
T22837	7474-7702	Sentence	denotes	More recently, high levels of activated STAT3, thought to be induced mainly by IL-6, have been detected in the ST, and STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37].
T22836	7251-7473	Sentence	denotes	IL-6 is the major STAT3-activating factor present in synovial fluid, which has a crucial role in the activation of monocyte functions such as gene expression of the Fc gamma receptor type I and type III and of HLA-DR [31].
T22835	7151-7250	Sentence	denotes	Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36].
T22834	7087-7150	Sentence	denotes	STAT3 activation has been implicated in the pathogenesis of RA.
T22833	6896-7086	Sentence	denotes	The T-cell-inhibitory effect of IL-10 may therefore be modulated complicatedly upon exposure to an inflammatory environment in RA joints, where many cytokines are present substantially [10].
T22832	6736-6895	Sentence	denotes	In an autocrine fashion, IL-10 may persistently stimulate STAT3 activation and IFN-γ can induce SOCS1 protein as a crosstalk inhibitor of IL-10 signaling [32].
T22831	6551-6735	Sentence	denotes	Furthermore, IFN-γ and IL-10 produced by CD4+ T cells themselves could be responsible for impaired IL-10 signaling in the ST, because T-cell infiltrates produce both cytokines [34,35].
T22830	6242-6550	Sentence	denotes	In addition, the involvement of other essential proinflammatory cytokines in this process was suggested by our preliminary experiments demonstrating that IL-10-mediated IFN-γ inhibition in CD4+ T cells was reduced by pretreatment with IL-1β and TNF-α, although less effectively than by IL-6 (data not shown).
T22829	6045-6241	Sentence	denotes	It is most probable that the resistance of CD4+ T cells to IL-10 can be even augmented after migration into the inflamed ST, because IL-6 is highly concentrated compared with the blood level [27].
T22828	5938-6044	Sentence	denotes	CD4+ T cells isolated from the ST of RA also showed a defect in the IL-10-induced STAT3 signaling pathway.
T22827	5663-5937	Sentence	denotes	However, it is also possible that STAT3 activity could be constitutively induced in CD4+ T cells by their own IL-10 secretion, leading to the loss of sensitivity to exogenous IL-10, because RA CD4+ T cells in the ST are capable of producing significant levels of IL-10 [34].
T22826	5452-5662	Sentence	denotes	These results suggest that both the sustained STAT3 activation and the resistance to IL-10 inhibition found in RA CD4+ T cells may be induced after chronic exposure in vivo to high concentrations of serum IL-6.
T22825	5224-5451	Sentence	denotes	Consistent with this notion, IL-6 was the major STAT3-activating factor contained in the serum of active RA patients, and the responsiveness to IL-10 was suppressed in normal CD4+ T cells after 36 hours of incubation with IL-6.
T22824	5035-5223	Sentence	denotes	Of these cytokines, IL-6 plays a predominant role in eliciting a systemic reaction such as the acute phase response in active RA, due mainly to its abundance in the blood circulation [27].
T22823	4841-5034	Sentence	denotes	STAT3 is activated by a variety of cytokines, notably the IL-6 family of cytokines (e.g. IL-6, IL-11, leukemia inhibitory factor, and oncostatin M) and growth factors, in addition to IL-10 [4].
T22822	4643-4840	Sentence	denotes	In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients.
T22821	4468-4642	Sentence	denotes	Inhibitory effects of IL-10 on these inflammatory cell types are therefore differentially modulated at the signal transduction level under the inflammatory environment in RA.
T22820	4299-4467	Sentence	denotes	We have demonstrated that the resistance of RA CD4+ T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression.
T22819	4008-4298	Sentence	denotes	Furthermore, dendritic cells from RA synovial fluids are resistant to the immunoregulatory effect of IL-10 due to decreased transport of intracellular IL-10R1 in the presence of proinflammatory cytokine stimuli such as TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15].
T22818	3693-4007	Sentence	denotes	This impaired IL-10 signaling is probably induced by chronic exposure to immune complexes in vivo, because both cell surface IL-10R1 expression and IL-10-induced Jak1 activation are suppressed in IFN-γ-primed macrophages by a protein kinase C-dependent pathway following ligation of the IgG Fc gamma receptor [14].
T22817	3592-3692	Sentence	denotes	More importantly, IL-10-mediated STAT3 activation is mostly undetectable in RA synovial macrophages.
T22816	3377-3591	Sentence	denotes	The activation of both the extracellular stimulus-regulated kinase and p38 kinase pathways, induced by TNF-α and IL-1, inhibits the Jak1–STAT3 signaling pathway shared by IL-10 and IL-6 in adhered macrophages [13].
T22815	3291-3376	Sentence	denotes	However, this regulatory activity seems to be restricted during chronic inflammation.
T22814	3166-3290	Sentence	denotes	Endogenous IL-10, produced mainly by macrophages and T cells, inhibits proinflammatory cytokine production by ST cells [12].
T22813	2974-3165	Sentence	denotes	Numerous cytokines, both proinflammatory and anti-inflammatory, have been detected in the ST of RA, and the balance between these opposing cytokine activities regulates disease severity [10].
T22812	2790-2973	Sentence	denotes	This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2.
T22811	2649-2789	Sentence	denotes	More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33].
T22810	2413-2648	Sentence	denotes	However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20].
T22809	2257-2412	Sentence	denotes	IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1].
T22808	1953-2256	Sentence	denotes	These findings indicate that CD4+ T cells become resistant to the inhibitory effect of IL-10 before migration into the inflamed ST, and suggest that this resistance may be attributable to impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1 induction.
T22807	1820-1952	Sentence	denotes	RA CD4+ T cells contain higher levels of SOCS1 but contain lower levels of SOCS3 transcripts in comparison with normal CD4+ T cells.
T22806	1641-1819	Sentence	denotes	Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells, and exogenous IL-6 induces the resistance to IL-10 inhibition of IFN-γ production.
T22805	1382-1640	Sentence	denotes	Despite high-level IL-10R1 expression and constitutive STAT3 activation, IL-10-induced tyrosine phosphorylation of STAT3 is suppressed in RA CD4+ T cells, in contrast to normal CD4+ T cells, where STAT3 phosphorylation is dose-dependently inducible by IL-10.
T22804	1172-1381	Sentence	denotes	In the present study, we found that PB CD4+ T cells from patients with active RA, in the presence of IL-10, are able to produce higher levels of IFN-γ after CD3 and CD28 costimulation than normal CD4+ T cells.
T22803	995-1171	Sentence	denotes	IL-10 inhibits the tyrosine phosphorylation of the CD28 molecule and the subsequent phosphatidylinositol 3-kinase binding in T cells, and thereby directly acts on T cells [24].
T22802	852-994	Sentence	denotes	IL-10 plays a predominant role in limiting immune and inflammatory responses by regulating the function of both macrophages and Th1 cells [1].
T22801	641-851	Sentence	denotes	The significance of CD28 engagement in the T-cell-mediated disease process has recently been proven by the clinical efficacy of its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23].
T22800	443-640	Sentence	denotes	In the ST lesion, the CD28 ligands, both CD80 and CD86, together with MHC class II antigens, are substantially expressed by antigen-presenting cells such as macrophages and dendritic cells [18-20].
T22799	333-442	Sentence	denotes	CD4+ T cells require two signals to be activated; antigen receptor occupancy and CD28-mediated costimulation.
T22798	91-332	Sentence	denotes	Activated CD4+ T cells stimulate macrophages, synovial fibroblasts, B cells, and osteoclasts through the expression of cell surface molecules and Th1 cytokines, thereby contributing to both the chronic inflammation and the joint destruction.
T22797	11-90	Sentence	denotes	CD4+ T cells orchestrate the Th1-type cell-mediated immune response in RA [22].
T139	0-10	Sentence	denotes	Discussion
T140	11-90	Sentence	denotes	CD4+ T cells orchestrate the Th1-type cell-mediated immune response in RA [22].
T141	91-332	Sentence	denotes	Activated CD4+ T cells stimulate macrophages, synovial fibroblasts, B cells, and osteoclasts through the expression of cell surface molecules and Th1 cytokines, thereby contributing to both the chronic inflammation and the joint destruction.
T142	333-442	Sentence	denotes	CD4+ T cells require two signals to be activated; antigen receptor occupancy and CD28-mediated costimulation.
T143	443-640	Sentence	denotes	In the ST lesion, the CD28 ligands, both CD80 and CD86, together with MHC class II antigens, are substantially expressed by antigen-presenting cells such as macrophages and dendritic cells [18-20].
T144	641-851	Sentence	denotes	The significance of CD28 engagement in the T-cell-mediated disease process has recently been proven by the clinical efficacy of its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23].
T145	852-994	Sentence	denotes	IL-10 plays a predominant role in limiting immune and inflammatory responses by regulating the function of both macrophages and Th1 cells [1].
T146	995-1171	Sentence	denotes	IL-10 inhibits the tyrosine phosphorylation of the CD28 molecule and the subsequent phosphatidylinositol 3-kinase binding in T cells, and thereby directly acts on T cells [24].
T147	1172-1381	Sentence	denotes	In the present study, we found that PB CD4+ T cells from patients with active RA, in the presence of IL-10, are able to produce higher levels of IFN-γ after CD3 and CD28 costimulation than normal CD4+ T cells.
T148	1382-1640	Sentence	denotes	Despite high-level IL-10R1 expression and constitutive STAT3 activation, IL-10-induced tyrosine phosphorylation of STAT3 is suppressed in RA CD4+ T cells, in contrast to normal CD4+ T cells, where STAT3 phosphorylation is dose-dependently inducible by IL-10.
T149	1641-1819	Sentence	denotes	Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells, and exogenous IL-6 induces the resistance to IL-10 inhibition of IFN-γ production.
T150	1820-1952	Sentence	denotes	RA CD4+ T cells contain higher levels of SOCS1 but contain lower levels of SOCS3 transcripts in comparison with normal CD4+ T cells.
T151	1953-2256	Sentence	denotes	These findings indicate that CD4+ T cells become resistant to the inhibitory effect of IL-10 before migration into the inflamed ST, and suggest that this resistance may be attributable to impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1 induction.
T152	2257-2412	Sentence	denotes	IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1].
T153	2413-2648	Sentence	denotes	However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20].
T154	2649-2789	Sentence	denotes	More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33].
T155	2790-2973	Sentence	denotes	This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2.
T156	2974-3165	Sentence	denotes	Numerous cytokines, both proinflammatory and anti-inflammatory, have been detected in the ST of RA, and the balance between these opposing cytokine activities regulates disease severity [10].
T157	3166-3290	Sentence	denotes	Endogenous IL-10, produced mainly by macrophages and T cells, inhibits proinflammatory cytokine production by ST cells [12].
T158	3291-3376	Sentence	denotes	However, this regulatory activity seems to be restricted during chronic inflammation.
T159	3377-3591	Sentence	denotes	The activation of both the extracellular stimulus-regulated kinase and p38 kinase pathways, induced by TNF-α and IL-1, inhibits the Jak1–STAT3 signaling pathway shared by IL-10 and IL-6 in adhered macrophages [13].
T160	3592-3692	Sentence	denotes	More importantly, IL-10-mediated STAT3 activation is mostly undetectable in RA synovial macrophages.
T161	3693-4007	Sentence	denotes	This impaired IL-10 signaling is probably induced by chronic exposure to immune complexes in vivo, because both cell surface IL-10R1 expression and IL-10-induced Jak1 activation are suppressed in IFN-γ-primed macrophages by a protein kinase C-dependent pathway following ligation of the IgG Fc gamma receptor [14].
T162	4008-4298	Sentence	denotes	Furthermore, dendritic cells from RA synovial fluids are resistant to the immunoregulatory effect of IL-10 due to decreased transport of intracellular IL-10R1 in the presence of proinflammatory cytokine stimuli such as TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15].
T163	4299-4467	Sentence	denotes	We have demonstrated that the resistance of RA CD4+ T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression.
T164	4468-4642	Sentence	denotes	Inhibitory effects of IL-10 on these inflammatory cell types are therefore differentially modulated at the signal transduction level under the inflammatory environment in RA.
T165	4643-4840	Sentence	denotes	In association with impaired IL-10-mediated STAT3 activation, STAT3 was found to be tyrosine phosphorylated persistently (up to 6 hours) in freshly isolated PB and ST CD4+ T cells from RA patients.
T166	4841-5034	Sentence	denotes	STAT3 is activated by a variety of cytokines, notably the IL-6 family of cytokines (e.g. IL-6, IL-11, leukemia inhibitory factor, and oncostatin M) and growth factors, in addition to IL-10 [4].
T167	5035-5223	Sentence	denotes	Of these cytokines, IL-6 plays a predominant role in eliciting a systemic reaction such as the acute phase response in active RA, due mainly to its abundance in the blood circulation [27].
T168	5224-5451	Sentence	denotes	Consistent with this notion, IL-6 was the major STAT3-activating factor contained in the serum of active RA patients, and the responsiveness to IL-10 was suppressed in normal CD4+ T cells after 36 hours of incubation with IL-6.
T169	5452-5662	Sentence	denotes	These results suggest that both the sustained STAT3 activation and the resistance to IL-10 inhibition found in RA CD4+ T cells may be induced after chronic exposure in vivo to high concentrations of serum IL-6.
T170	5663-5937	Sentence	denotes	However, it is also possible that STAT3 activity could be constitutively induced in CD4+ T cells by their own IL-10 secretion, leading to the loss of sensitivity to exogenous IL-10, because RA CD4+ T cells in the ST are capable of producing significant levels of IL-10 [34].
T171	5938-6044	Sentence	denotes	CD4+ T cells isolated from the ST of RA also showed a defect in the IL-10-induced STAT3 signaling pathway.
T172	6045-6241	Sentence	denotes	It is most probable that the resistance of CD4+ T cells to IL-10 can be even augmented after migration into the inflamed ST, because IL-6 is highly concentrated compared with the blood level [27].
T173	6242-6550	Sentence	denotes	In addition, the involvement of other essential proinflammatory cytokines in this process was suggested by our preliminary experiments demonstrating that IL-10-mediated IFN-γ inhibition in CD4+ T cells was reduced by pretreatment with IL-1β and TNF-α, although less effectively than by IL-6 (data not shown).
T174	6551-6735	Sentence	denotes	Furthermore, IFN-γ and IL-10 produced by CD4+ T cells themselves could be responsible for impaired IL-10 signaling in the ST, because T-cell infiltrates produce both cytokines [34,35].
T175	6736-6895	Sentence	denotes	In an autocrine fashion, IL-10 may persistently stimulate STAT3 activation and IFN-γ can induce SOCS1 protein as a crosstalk inhibitor of IL-10 signaling [32].
T176	6896-7086	Sentence	denotes	The T-cell-inhibitory effect of IL-10 may therefore be modulated complicatedly upon exposure to an inflammatory environment in RA joints, where many cytokines are present substantially [10].
T177	7087-7150	Sentence	denotes	STAT3 activation has been implicated in the pathogenesis of RA.
T178	7151-7250	Sentence	denotes	Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36].
T179	7251-7473	Sentence	denotes	IL-6 is the major STAT3-activating factor present in synovial fluid, which has a crucial role in the activation of monocyte functions such as gene expression of the Fc gamma receptor type I and type III and of HLA-DR [31].
T180	7474-7702	Sentence	denotes	More recently, high levels of activated STAT3, thought to be induced mainly by IL-6, have been detected in the ST, and STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37].
T181	7703-7820	Sentence	denotes	In this regard, STAT3 is critical in the survival and expansion of growth factor-dependent synovial fibroblasts [38].
T182	7821-8173	Sentence	denotes	Furthermore, the significance of persistent STAT3 signaling in Th1-cell-dominated autoimmune arthritis has been suggested by studies of the gp130F759/F759 mice, in which the Src homology phosphatase-2 binding site of gp130 (the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor), tyrosine 759, was mutated to phenylalanine [39].
T183	8174-8361	Sentence	denotes	In the gp130F759/F759 mice, T cells, particularly the CD4+ T-cell subset, are chronically activated and resistant to activation-induced cell death through gp130-mediated STAT3 activation.
T184	8362-8476	Sentence	denotes	The longevity of cytokine signals transduced by the JAK–STAT pathway is regulated by the SOCS family proteins [7].
T185	8477-8628	Sentence	denotes	We found that CD4+ T cells from patients with active RA expressed higher levels of SOCS1, but lower levels of SOCS3, compared with normal CD4+ T cells.
T186	8629-8819	Sentence	denotes	SOCS1 prevents activation of JAK by directly binding to JAK, and SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40].
T187	8820-8959	Sentence	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7].
T188	8960-9097	Sentence	denotes	Recent studies with mice lacking SOCS3 or SOCS1 revealed that SOCS3 is a negative regulator of IL-6 signaling but not of IL-10 signaling.
T189	9098-9270	Sentence	denotes	Studies of conditional SOCS3-deficient mice have shown that SOCS3 deficiency, but not SOCS1 deficiency, results in sustained activation of STAT3 in response to IL-6 [8,41].
T190	9271-9413	Sentence	denotes	The analysis of SOCS3-deficient macrophages has indicated that SOCS3 is a crucial inhibitor of the IL-6-induced transcriptional response [42].
T191	9414-9547	Sentence	denotes	However, SOCS3 is dispensable for both the negative feedback inhibition and the immunoregulatory action of IL-10 in macrophages [41].
T192	9548-9631	Sentence	denotes	On the contrary, SOCS1 was found to directly inhibit IL-10-mediated signaling [43].
T193	9632-9901	Sentence	denotes	Increased SOCS1 expression in RA CD4+ T cells may therefore be associated with both the impaired responsiveness to IL-10 and to IL-10-mediated STAT3 activation, and defective SOCS3 expression may be responsible for persistent STAT3 activation in response to serum IL-6.
T194	9902-10179	Sentence	denotes	There is a possibility that SOCS1 induction may be associated with the ability of CD4+ T cells to produce IFN-γ, because CD4+ T cells from active RA could produce high levels of IFN-γ in the presence of IL-10, and because IFN-γ has been known as a potent inducer of SOCS1 [32].
T195	10180-10321	Sentence	denotes	It is of interest in this regard to indicate that polarized Th1 and Th2 cells express high levels of SOCS1 and SOCS3 mRNA, respectively [44].
T196	10322-10482	Sentence	denotes	IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells, whereas IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells.
T197	10483-10676	Sentence	denotes	SOCS1 and SOCS3 may thus have important roles as Th1-specific and Th2-specific, mutually exclusive, cross-talk repressors of the IL-4–STAT6 and the IL-12–STAT4 signaling pathways, respectively.
T198	10677-10900	Sentence	denotes	Consistent with this notion, PB T cells from patients with allergic diseases significantly express high levels of SOCS3 transcripts, and the SOCS3 expression correlates well with serum IgE levels and disease pathology [45].
T199	10901-11149	Sentence	denotes	Higher SOCS1 expression with lower SOCS3 expression in PB CD4+ T cells from RA patients, compared with healthy controls, is therefore probably consistent with their systemic bias towards a Th1 phenotype, as has previously been demonstrated [46-49].

ICD10

Id	Subject	Object	Predicate	Lexical cue
T23695	7914-7923	http://purl.bioontology.org/ontology/ICD10/M13.9	denotes	arthritis

simple1

Id	Subject	Object	Predicate	Lexical cue
T24488	10959-10962	Protein	denotes	CD4
T24487	10936-10941	Protein	denotes	SOCS3
T24486	10908-10913	Protein	denotes	SOCS1
T24485	10818-10823	Protein	denotes	SOCS3
T24484	10791-10796	Protein	denotes	SOCS3
T24483	10637-10642	Protein	denotes	STAT4
T24482	10631-10636	Protein	denotes	IL-12
T24467	10105-10110	Protein	denotes	IL-10
T24466	10080-10085	Protein	denotes	IFN-γ
T24465	10023-10026	Protein	denotes	CD4
T24464	10008-10013	Protein	denotes	IFN-γ
T24463	9984-9987	Protein	denotes	CD4
T24462	9930-9935	Protein	denotes	SOCS1
T24461	9896-9900	Protein	denotes	IL-6
T24460	9858-9863	Protein	denotes	STAT3
T24459	9807-9812	Protein	denotes	SOCS3
T24458	9775-9780	Protein	denotes	STAT3
T24457	9760-9765	Protein	denotes	IL-10
T24456	9747-9752	Protein	denotes	IL-10
T24455	9665-9668	Protein	denotes	CD4
T24327	2664-2669	Protein	denotes	IL-10
T24326	2595-2599	Protein	denotes	CD86
T24325	2586-2590	Protein	denotes	CD80
T24324	2286-2289	Protein	denotes	CD4
T24323	2257-2262	Protein	denotes	IL-10
T24322	2240-2245	Protein	denotes	SOCS1
T24321	2214-2219	Protein	denotes	STAT3
T24320	2166-2171	Protein	denotes	STAT3
T24319	2150-2155	Protein	denotes	IL-10
T24318	2040-2045	Protein	denotes	IL-10
T24317	1982-1985	Protein	denotes	CD4
T24316	1939-1942	Protein	denotes	CD4
T24315	1895-1900	Protein	denotes	SOCS3
T24314	1861-1866	Protein	denotes	SOCS1
T24313	1823-1826	Protein	denotes	CD4
T24312	1802-1807	Protein	denotes	IFN-γ
T24311	1782-1787	Protein	denotes	IL-10
T24310	1751-1755	Protein	denotes	IL-6
T24309	1723-1726	Protein	denotes	CD4
T24308	1691-1696	Protein	denotes	STAT1
T24307	1677-1682	Protein	denotes	STAT3
T24306	1647-1651	Protein	denotes	IL-6
T24305	1634-1639	Protein	denotes	IL-10
T24304	1579-1584	Protein	denotes	STAT3
T24303	1559-1562	Protein	denotes	CD4
T24302	1523-1526	Protein	denotes	CD4
T24301	1497-1502	Protein	denotes	STAT3
T24300	1455-1460	Protein	denotes	IL-10
T24299	1437-1442	Protein	denotes	STAT3
T24298	1401-1408	Protein	denotes	IL-10R1
T24297	1368-1371	Protein	denotes	CD4
T24296	1337-1341	Protein	denotes	CD28
T24295	1317-1322	Protein	denotes	IFN-γ
T24294	1273-1278	Protein	denotes	IL-10
T24293	1211-1214	Protein	denotes	CD4
T24292	1046-1050	Protein	denotes	CD28
T24291	995-1000	Protein	denotes	IL-10
T24290	852-857	Protein	denotes	IL-10
T24289	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T24288	661-665	Protein	denotes	CD28
T24287	493-497	Protein	denotes	CD86
T24286	484-488	Protein	denotes	CD80
T24285	465-469	Protein	denotes	CD28
T24284	414-418	Protein	denotes	CD28
T24283	333-336	Protein	denotes	CD4
T24282	101-104	Protein	denotes	CD4
T24281	11-14	Protein	denotes	CD4
T24454	9642-9647	Protein	denotes	SOCS1
T24453	9601-9606	Protein	denotes	IL-10
T24452	9565-9570	Protein	denotes	SOCS1
T24451	9521-9526	Protein	denotes	IL-10
T24450	9423-9428	Protein	denotes	SOCS3
T24449	9370-9374	Protein	denotes	IL-6
T24448	9334-9339	Protein	denotes	SOCS3
T24447	9287-9292	Protein	denotes	SOCS3
T24446	9258-9262	Protein	denotes	IL-6
T24445	9237-9242	Protein	denotes	STAT3
T24444	9184-9189	Protein	denotes	SOCS1
T24443	9158-9163	Protein	denotes	SOCS3
T24442	9121-9126	Protein	denotes	SOCS3
T24441	9081-9086	Protein	denotes	IL-10
T24440	9055-9059	Protein	denotes	IL-6
T24439	9022-9027	Protein	denotes	SOCS3
T24438	9002-9007	Protein	denotes	SOCS1
T24437	8993-8998	Protein	denotes	SOCS3
T24436	8889-8894	Protein	denotes	IL-10
T24435	8880-8884	Protein	denotes	IL-6
T24434	8830-8835	Protein	denotes	SOCS3
T24433	8820-8825	Protein	denotes	SOCS1
T24432	8808-8813	Protein	denotes	gp130
T24431	8694-8699	Protein	denotes	SOCS3
T24430	8629-8634	Protein	denotes	SOCS1
T24429	8615-8618	Protein	denotes	CD4
T24428	8587-8592	Protein	denotes	SOCS3
T24427	8560-8565	Protein	denotes	SOCS1
T24426	8491-8494	Protein	denotes	CD4
T24425	8344-8349	Protein	denotes	STAT3
T24424	8329-8334	Protein	denotes	gp130
T24423	8228-8231	Protein	denotes	CD4
T24422	8181-8186	Protein	denotes	gp130
T24421	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T24420	8038-8043	Protein	denotes	gp130
T24419	7961-7966	Protein	denotes	gp130
T24418	7865-7870	Protein	denotes	STAT3
T24417	7719-7724	Protein	denotes	STAT3
T24416	7681-7685	Protein	denotes	IL-6
T24415	7593-7598	Protein	denotes	STAT3
T24414	7553-7557	Protein	denotes	IL-6
T24413	7514-7519	Protein	denotes	STAT3
T24412	7445-7453	Protein	denotes	type III
T24411	7416-7440	Protein	denotes	Fc gamma receptor type I
T24410	7269-7274	Protein	denotes	STAT3
T24409	7251-7255	Protein	denotes	IL-6
T24408	7158-7163	Protein	denotes	STAT3
T24407	7087-7092	Protein	denotes	STAT3
T24406	6928-6933	Protein	denotes	IL-10
T24405	6874-6879	Protein	denotes	IL-10
T24404	6832-6837	Protein	denotes	SOCS1
T24403	6815-6820	Protein	denotes	IFN-γ
T24402	6794-6799	Protein	denotes	STAT3
T24401	6761-6766	Protein	denotes	IL-10
T24400	6650-6655	Protein	denotes	IL-10
T24399	6592-6595	Protein	denotes	CD4
T24398	6574-6579	Protein	denotes	IL-10
T24397	6564-6569	Protein	denotes	IFN-γ
T24396	6528-6532	Protein	denotes	IL-6
T24395	6487-6492	Protein	denotes	TNF-α
T24394	6477-6482	Protein	denotes	IL-1β
T24393	6431-6434	Protein	denotes	CD4
T24392	6411-6416	Protein	denotes	IFN-γ
T24391	6396-6401	Protein	denotes	IL-10
T24390	6178-6182	Protein	denotes	IL-6
T24389	6104-6109	Protein	denotes	IL-10
T24388	6088-6091	Protein	denotes	CD4
T24387	6020-6025	Protein	denotes	STAT3
T24386	6006-6011	Protein	denotes	IL-10
T24385	5938-5941	Protein	denotes	CD4
T24384	5926-5931	Protein	denotes	IL-10
T24383	5856-5859	Protein	denotes	CD4
T24382	5838-5843	Protein	denotes	IL-10
T24381	5773-5778	Protein	denotes	IL-10
T24380	5747-5750	Protein	denotes	CD4
T24379	5697-5702	Protein	denotes	STAT3
T24378	5657-5661	Protein	denotes	IL-6
T24377	5566-5569	Protein	denotes	CD4
T24376	5537-5542	Protein	denotes	IL-10
T24375	5498-5503	Protein	denotes	STAT3
T24374	5446-5450	Protein	denotes	IL-6
T24373	5399-5402	Protein	denotes	CD4
T24372	5368-5373	Protein	denotes	IL-10
T24371	5272-5277	Protein	denotes	STAT3
T24370	5253-5257	Protein	denotes	IL-6
T24369	5055-5059	Protein	denotes	IL-6
T24368	5024-5029	Protein	denotes	IL-10
T24367	4975-4987	Protein	denotes	oncostatin M
T24366	4943-4969	Protein	denotes	leukemia inhibitory factor
T24365	4936-4941	Protein	denotes	IL-11
T24364	4930-4934	Protein	denotes	IL-6
T24363	4841-4846	Protein	denotes	STAT3
T24362	4810-4813	Protein	denotes	CD4
T24361	4705-4710	Protein	denotes	STAT3
T24360	4687-4692	Protein	denotes	STAT3
T24359	4672-4677	Protein	denotes	IL-10
T24358	4490-4495	Protein	denotes	IL-10
T24357	4448-4455	Protein	denotes	IL-10R1
T24356	4417-4422	Protein	denotes	STAT3
T24355	4401-4406	Protein	denotes	IL-10
T24354	4362-4367	Protein	denotes	IL-10
T24353	4346-4349	Protein	denotes	CD4
T24352	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T24351	4234-4238	Protein	denotes	IL-1
T24350	4227-4232	Protein	denotes	TNF-α
T24349	4159-4166	Protein	denotes	IL-10R1
T24348	4109-4114	Protein	denotes	IL-10
T24347	3889-3894	Protein	denotes	IFN-γ
T24346	3855-3859	Protein	denotes	Jak1
T24345	3841-3846	Protein	denotes	IL-10
T24344	3818-3825	Protein	denotes	IL-10R1
T24343	3707-3712	Protein	denotes	IL-10
T24342	3625-3630	Protein	denotes	STAT3
T24341	3610-3615	Protein	denotes	IL-10
T24340	3558-3562	Protein	denotes	IL-6
T24339	3548-3553	Protein	denotes	IL-10
T24338	3514-3519	Protein	denotes	STAT3
T24337	3509-3513	Protein	denotes	Jak1
T24336	3490-3494	Protein	denotes	IL-1
T24335	3480-3485	Protein	denotes	TNF-α
T24334	3177-3182	Protein	denotes	IL-10
T24333	2968-2972	Protein	denotes	IL-2
T24332	2958-2963	Protein	denotes	IFN-γ
T24331	2921-2925	Protein	denotes	CD28
T24330	2901-2906	Protein	denotes	IL-10
T24329	2869-2872	Protein	denotes	CD4
T24328	2754-2758	Protein	denotes	CD28
T24481	10617-10622	Protein	denotes	STAT6
T24480	10612-10616	Protein	denotes	IL-4
T24479	10493-10498	Protein	denotes	SOCS3
T24478	10483-10488	Protein	denotes	SOCS1
T24477	10453-10458	Protein	denotes	SOCS1
T24476	10420-10425	Protein	denotes	STAT6
T24475	10407-10411	Protein	denotes	IL-4
T24474	10369-10374	Protein	denotes	SOCS3
T24473	10336-10341	Protein	denotes	STAT4
T24472	10322-10327	Protein	denotes	IL-12
T24471	10291-10296	Protein	denotes	SOCS3
T24470	10281-10286	Protein	denotes	SOCS1
T24469	10168-10173	Protein	denotes	SOCS1
T24468	10124-10129	Protein	denotes	IFN-γ

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T30335	1697-1712	Phosphorylation	denotes	phosphorylation
T30334	1409-1419	Gene_expression	denotes	expression
T30333	1585-1600	Phosphorylation	denotes	phosphorylation
T30332	1621-1630	Positive_regulation	denotes	inducible
T30331	1461-1468	Positive_regulation	denotes	induced
T30330	1506-1516	Negative_regulation	denotes	suppressed
T30329	1478-1493	Phosphorylation	denotes	phosphorylation
T30328	1443-1453	Positive_regulation	denotes	activation
T30327	1292-1299	Gene_expression	denotes	produce
T30326	1023-1038	Phosphorylation	denotes	phosphorylation
T30325	1001-1009	Negative_regulation	denotes	inhibits
T30324	666-676	Binding	denotes	engagement
T30323	554-563	Gene_expression	denotes	expressed
T30322	10959-10962	Protein	denotes	CD4
T30321	10936-10941	Protein	denotes	SOCS3
T30320	10908-10913	Protein	denotes	SOCS1
T30319	10818-10823	Protein	denotes	SOCS3
T30317	10637-10642	Protein	denotes	STAT4
T30316	10631-10636	Protein	denotes	IL-12
T30315	10617-10622	Protein	denotes	STAT6
T30314	10612-10616	Protein	denotes	IL-4
T30313	10493-10498	Protein	denotes	SOCS3
T30312	10483-10488	Protein	denotes	SOCS1
T30311	10453-10458	Protein	denotes	SOCS1
T30310	10420-10425	Protein	denotes	STAT6
T30309	10407-10411	Protein	denotes	IL-4
T30308	10369-10374	Protein	denotes	SOCS3
T30307	10336-10341	Protein	denotes	STAT4
T30306	10322-10327	Protein	denotes	IL-12
T30305	10291-10296	Protein	denotes	SOCS3
T30304	10281-10286	Protein	denotes	SOCS1
T30303	10168-10173	Protein	denotes	SOCS1
T30302	10124-10129	Protein	denotes	IFN-γ
T30301	10105-10110	Protein	denotes	IL-10
T30300	10080-10085	Protein	denotes	IFN-γ
T30299	10023-10026	Protein	denotes	CD4
T30298	10008-10013	Protein	denotes	IFN-γ
T30297	9984-9987	Protein	denotes	CD4
T30296	9930-9935	Protein	denotes	SOCS1
T30295	9896-9900	Protein	denotes	IL-6
T30294	9858-9863	Protein	denotes	STAT3
T30293	9807-9812	Protein	denotes	SOCS3
T30292	9775-9780	Protein	denotes	STAT3
T30291	9760-9765	Protein	denotes	IL-10
T30290	9747-9752	Protein	denotes	IL-10
T30289	9665-9668	Protein	denotes	CD4
T30288	9642-9647	Protein	denotes	SOCS1
T30287	9601-9606	Protein	denotes	IL-10
T30286	9565-9570	Protein	denotes	SOCS1
T30285	9521-9526	Protein	denotes	IL-10
T30284	9423-9428	Protein	denotes	SOCS3
T30283	9370-9374	Protein	denotes	IL-6
T30282	9334-9339	Protein	denotes	SOCS3
T30281	9287-9292	Protein	denotes	SOCS3
T30280	9258-9262	Protein	denotes	IL-6
T30279	9237-9242	Protein	denotes	STAT3
T30278	9184-9189	Protein	denotes	SOCS1
T30277	9158-9163	Protein	denotes	SOCS3
T30276	9121-9126	Protein	denotes	SOCS3
T30275	9081-9086	Protein	denotes	IL-10
T30274	9055-9059	Protein	denotes	IL-6
T30273	9022-9027	Protein	denotes	SOCS3
T30272	9002-9007	Protein	denotes	SOCS1
T30271	8993-8998	Protein	denotes	SOCS3
T30270	8889-8894	Protein	denotes	IL-10
T30269	8880-8884	Protein	denotes	IL-6
T30268	8830-8835	Protein	denotes	SOCS3
T30267	8820-8825	Protein	denotes	SOCS1
T30266	8808-8813	Protein	denotes	gp130
T30265	8694-8699	Protein	denotes	SOCS3
T30264	8629-8634	Protein	denotes	SOCS1
T30263	8615-8618	Protein	denotes	CD4
T30262	8587-8592	Protein	denotes	SOCS3
T30261	8560-8565	Protein	denotes	SOCS1
T30260	8491-8494	Protein	denotes	CD4
T30259	8344-8349	Protein	denotes	STAT3
T30258	8329-8334	Protein	denotes	gp130
T30257	8228-8231	Protein	denotes	CD4
T30256	8181-8186	Protein	denotes	gp130
T30255	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T30254	8038-8043	Protein	denotes	gp130
T30253	7961-7966	Protein	denotes	gp130
T30252	7865-7870	Protein	denotes	STAT3
T30251	7719-7724	Protein	denotes	STAT3
T30250	7681-7685	Protein	denotes	IL-6
T30249	7593-7598	Protein	denotes	STAT3
T30248	7553-7557	Protein	denotes	IL-6
T30247	7514-7519	Protein	denotes	STAT3
T30246	7445-7453	Protein	denotes	type III
T30245	7416-7440	Protein	denotes	Fc gamma receptor type I
T30244	7269-7274	Protein	denotes	STAT3
T30243	7251-7255	Protein	denotes	IL-6
T30242	7158-7163	Protein	denotes	STAT3
T30241	7087-7092	Protein	denotes	STAT3
T30240	6928-6933	Protein	denotes	IL-10
T30239	6874-6879	Protein	denotes	IL-10
T30238	6832-6837	Protein	denotes	SOCS1
T30237	6815-6820	Protein	denotes	IFN-γ
T30236	6794-6799	Protein	denotes	STAT3
T30235	6761-6766	Protein	denotes	IL-10
T30234	6650-6655	Protein	denotes	IL-10
T30233	6592-6595	Protein	denotes	CD4
T30232	6574-6579	Protein	denotes	IL-10
T30231	6564-6569	Protein	denotes	IFN-γ
T30230	6528-6532	Protein	denotes	IL-6
T30229	6487-6492	Protein	denotes	TNF-α
T30228	6477-6482	Protein	denotes	IL-1β
T30227	6431-6434	Protein	denotes	CD4
T30226	6411-6416	Protein	denotes	IFN-γ
T30225	6396-6401	Protein	denotes	IL-10
T30224	6178-6182	Protein	denotes	IL-6
T30223	6104-6109	Protein	denotes	IL-10
T30222	6088-6091	Protein	denotes	CD4
T30221	6020-6025	Protein	denotes	STAT3
T30220	6006-6011	Protein	denotes	IL-10
T30219	5938-5941	Protein	denotes	CD4
T30218	5926-5931	Protein	denotes	IL-10
T30217	5856-5859	Protein	denotes	CD4
T30216	5838-5843	Protein	denotes	IL-10
T30215	5773-5778	Protein	denotes	IL-10
T30214	5747-5750	Protein	denotes	CD4
T30213	5697-5702	Protein	denotes	STAT3
T30212	5657-5661	Protein	denotes	IL-6
T30211	5566-5569	Protein	denotes	CD4
T30210	5537-5542	Protein	denotes	IL-10
T30209	5498-5503	Protein	denotes	STAT3
T30208	5446-5450	Protein	denotes	IL-6
T30207	5399-5402	Protein	denotes	CD4
T30206	5368-5373	Protein	denotes	IL-10
T30205	5272-5277	Protein	denotes	STAT3
T30204	5253-5257	Protein	denotes	IL-6
T30203	5055-5059	Protein	denotes	IL-6
T30202	5024-5029	Protein	denotes	IL-10
T30201	4975-4987	Protein	denotes	oncostatin M
T30200	4943-4969	Protein	denotes	leukemia inhibitory factor
T30199	4936-4941	Protein	denotes	IL-11
T30198	4930-4934	Protein	denotes	IL-6
T30197	4841-4846	Protein	denotes	STAT3
T30196	4810-4813	Protein	denotes	CD4
T30195	4705-4710	Protein	denotes	STAT3
T30194	4687-4692	Protein	denotes	STAT3
T30193	4672-4677	Protein	denotes	IL-10
T30192	4490-4495	Protein	denotes	IL-10
T30191	4448-4455	Protein	denotes	IL-10R1
T30190	4417-4422	Protein	denotes	STAT3
T30189	4401-4406	Protein	denotes	IL-10
T30188	4362-4367	Protein	denotes	IL-10
T30187	4346-4349	Protein	denotes	CD4
T30186	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T30185	4234-4238	Protein	denotes	IL-1
T30184	4227-4232	Protein	denotes	TNF-α
T30183	4159-4166	Protein	denotes	IL-10R1
T30182	4109-4114	Protein	denotes	IL-10
T30181	3889-3894	Protein	denotes	IFN-γ
T30180	3855-3859	Protein	denotes	Jak1
T30179	3841-3846	Protein	denotes	IL-10
T30178	3818-3825	Protein	denotes	IL-10R1
T30177	3707-3712	Protein	denotes	IL-10
T30176	3625-3630	Protein	denotes	STAT3
T30175	3610-3615	Protein	denotes	IL-10
T30174	3509-3513	Protein	denotes	Jak1
T30173	3490-3494	Protein	denotes	IL-1
T30172	3480-3485	Protein	denotes	TNF-α
T30171	3558-3562	Protein	denotes	IL-6
T30170	3548-3553	Protein	denotes	IL-10
T30169	3514-3519	Protein	denotes	STAT3
T30168	3177-3182	Protein	denotes	IL-10
T30167	2968-2972	Protein	denotes	IL-2
T30166	2958-2963	Protein	denotes	IFN-γ
T30165	2921-2925	Protein	denotes	CD28
T30164	2901-2906	Protein	denotes	IL-10
T30163	2869-2872	Protein	denotes	CD4
T30162	2754-2758	Protein	denotes	CD28
T30161	2664-2669	Protein	denotes	IL-10
T30160	2595-2599	Protein	denotes	CD86
T30159	2586-2590	Protein	denotes	CD80
T30158	2286-2289	Protein	denotes	CD4
T30157	2257-2262	Protein	denotes	IL-10
T30156	2240-2245	Protein	denotes	SOCS1
T30155	2214-2219	Protein	denotes	STAT3
T30154	2166-2171	Protein	denotes	STAT3
T30153	2150-2155	Protein	denotes	IL-10
T30152	2040-2045	Protein	denotes	IL-10
T30151	1982-1985	Protein	denotes	CD4
T30150	1939-1942	Protein	denotes	CD4
T30149	1895-1900	Protein	denotes	SOCS3
T30148	1861-1866	Protein	denotes	SOCS1
T30147	1823-1826	Protein	denotes	CD4
T30146	1802-1807	Protein	denotes	IFN-γ
T30145	1782-1787	Protein	denotes	IL-10
T30144	1751-1755	Protein	denotes	IL-6
T30143	1723-1726	Protein	denotes	CD4
T30142	1691-1696	Protein	denotes	STAT1
T30141	1677-1682	Protein	denotes	STAT3
T30140	1647-1651	Protein	denotes	IL-6
T30139	1634-1639	Protein	denotes	IL-10
T30138	1579-1584	Protein	denotes	STAT3
T30137	1559-1562	Protein	denotes	CD4
T30136	1523-1526	Protein	denotes	CD4
T30135	1497-1502	Protein	denotes	STAT3
T30134	1455-1460	Protein	denotes	IL-10
T30133	1437-1442	Protein	denotes	STAT3
T30132	1401-1408	Protein	denotes	IL-10R1
T30131	1368-1371	Protein	denotes	CD4
T30130	1337-1341	Protein	denotes	CD28
T30129	1317-1322	Protein	denotes	IFN-γ
T30128	1273-1278	Protein	denotes	IL-10
T30127	1211-1214	Protein	denotes	CD4
T30126	1046-1050	Protein	denotes	CD28
T30125	995-1000	Protein	denotes	IL-10
T30124	852-857	Protein	denotes	IL-10
T30123	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T30122	661-665	Protein	denotes	CD28
T30121	493-497	Protein	denotes	CD86
T30120	484-488	Protein	denotes	CD80
T30118	414-418	Protein	denotes	CD28
T30117	333-336	Protein	denotes	CD4
T30116	101-104	Protein	denotes	CD4
T30115	11-14	Protein	denotes	CD4
T30408	9648-9658	Gene_expression	denotes	expression
T30407	9632-9641	Positive_regulation	denotes	Increased
T30406	9864-9874	Positive_regulation	denotes	activation
T30405	9797-9806	Negative_regulation	denotes	defective
T30404	9831-9842	Positive_regulation	denotes	responsible
T30403	9813-9823	Gene_expression	denotes	expression
T30402	9781-9791	Positive_regulation	denotes	activation
T30401	9432-9443	Positive_regulation	denotes	dispensable
T30400	9293-9302	Negative_regulation	denotes	deficient
T30399	9375-9382	Positive_regulation	denotes	induced
T30398	9353-9362	Negative_regulation	denotes	inhibitor
T30397	9190-9200	Negative_regulation	denotes	deficiency
T30396	9246-9254	Positive_regulation	denotes	response
T30395	9127-9136	Negative_regulation	denotes	deficient
T30394	9164-9174	Negative_regulation	denotes	deficiency
T30393	9223-9233	Positive_regulation	denotes	activation
T30392	8985-8992	Negative_regulation	denotes	lacking
T30391	8840-8847	Positive_regulation	denotes	induced
T30390	8730-8737	Binding	denotes	binding
T30389	8674-8681	Binding	denotes	binding
T30388	8533-8542	Gene_expression	denotes	expressed
T30387	8350-8360	Positive_regulation	denotes	activation
T30386	7686-7696	Gene_expression	denotes	production
T30385	7599-7609	Positive_regulation	denotes	activation
T30384	7535-7542	Positive_regulation	denotes	induced
T30383	7504-7513	Positive_regulation	denotes	activated
T30382	7352-7362	Positive_regulation	denotes	activation
T30381	7398-7408	Gene_expression	denotes	expression
T30380	7182-7191	Gene_expression	denotes	expressed
T30379	7093-7103	Positive_regulation	denotes	activation
T30378	6784-6793	Positive_regulation	denotes	stimulate
T30377	6800-6810	Positive_regulation	denotes	activation
T30376	6580-6588	Gene_expression	denotes	produced
T30375	6448-6455	Negative_regulation	denotes	reduced
T30374	6417-6427	Negative_regulation	denotes	inhibition
T30373	6122-6131	Positive_regulation	denotes	augmented
T30372	6193-6205	Positive_regulation	denotes	concentrated
T30371	6012-6019	Positive_regulation	denotes	induced
T30370	5894-5903	Gene_expression	denotes	producing
T30369	5779-5788	Localization	denotes	secretion
T30368	5736-5743	Positive_regulation	denotes	induced
T30367	5586-5593	Positive_regulation	denotes	induced
T30366	5543-5553	Negative_regulation	denotes	inhibition
T30365	5504-5514	Positive_regulation	denotes	activation
T30364	4850-4859	Positive_regulation	denotes	activated
T30363	4693-4703	Positive_regulation	denotes	activation
T30362	4736-4750	Phosphorylation	denotes	phosphorylated
T30361	4423-4433	Positive_regulation	denotes	activation
T30360	4391-4400	Negative_regulation	denotes	defective
T30359	4456-4466	Gene_expression	denotes	expression
T30358	4122-4131	Negative_regulation	denotes	decreased
T30357	3826-3836	Gene_expression	denotes	expression
T30356	3847-3854	Positive_regulation	denotes	induced
T30355	3860-3870	Positive_regulation	denotes	activation
T30354	3875-3885	Negative_regulation	denotes	suppressed
T30353	3616-3624	Positive_regulation	denotes	mediated
T30352	3631-3641	Positive_regulation	denotes	activation
T30351	3184-3192	Gene_expression	denotes	produced
T30350	2891-2900	Negative_regulation	denotes	defective
T30349	2907-2917	Negative_regulation	denotes	inhibition
T30348	2939-2949	Gene_expression	denotes	production
T30347	2926-2938	Positive_regulation	denotes	costimulated
T30346	2768-2783	Phosphorylation	denotes	phosphorylation
T30345	2743-2753	Negative_regulation	denotes	inhibiting
T30344	2552-2559	Gene_expression	denotes	express
T30343	2172-2182	Positive_regulation	denotes	activation
T30342	2246-2255	Positive_regulation	denotes	induction
T30341	2141-2149	Negative_regulation	denotes	impaired
T30340	2220-2235	Phosphorylation	denotes	phosphorylation
T30339	1808-1818	Gene_expression	denotes	production
T30338	1669-1676	Positive_regulation	denotes	induces
T30337	1756-1763	Positive_regulation	denotes	induces
T30336	1788-1798	Negative_regulation	denotes	inhibition
T30119	465-469	Protein	denotes	CD28
T30318	10791-10796	Protein	denotes	SOCS3
T30424	10942-10952	Gene_expression	denotes	expression
T30423	10914-10924	Gene_expression	denotes	expression
T30422	10901-10907	Positive_regulation	denotes	Higher
T30421	10824-10834	Gene_expression	denotes	expression
T30420	10768-10775	Gene_expression	denotes	express
T30419	10439-10449	Negative_regulation	denotes	diminished
T30418	10356-10365	Negative_regulation	denotes	inhibited
T30417	10342-10352	Positive_regulation	denotes	activation
T30416	10375-10384	Positive_regulation	denotes	induction
T30415	10328-10335	Positive_regulation	denotes	induced
T30414	10412-10419	Positive_regulation	denotes	induced
T30413	10459-10468	Positive_regulation	denotes	induction
T30412	10258-10265	Gene_expression	denotes	express
T30411	10000-10007	Gene_expression	denotes	produce
T30410	10157-10164	Positive_regulation	denotes	inducer
T30409	9936-9945	Positive_regulation	denotes	induction
R16069	T30223	T30373	themeOf	IL-10,augmented
R16070	T30120	T30323	themeOf	CD80,expressed
R16071	T30121	T30323	themeOf	CD86,expressed
R16072	T30122	T30324	themeOf	CD28,engagement
R16073	T30224	T30372	themeOf	IL-6,concentrated
R16074	T30226	T30374	themeOf	IFN-γ,inhibition
R16075	T30126	T30326	themeOf	CD28,phosphorylation
R16076	T30231	T30376	themeOf	IFN-γ,produced
R16077	T30129	T30327	themeOf	IFN-γ,produce
R16078	T30232	T30376	themeOf	IL-10,produced
R16083	T30236	T30377	themeOf	STAT3,activation
R16091	T30241	T30379	themeOf	STAT3,activation
R16096	T30242	T30380	themeOf	STAT3,expressed
R16097	T30245	T30381	themeOf	Fc gamma receptor type I,expression
R16098	T30246	T30381	themeOf	type III,expression
R16099	T30154	T30343	themeOf	STAT3,activation
R16100	T30155	T30340	themeOf	STAT3,phosphorylation
R16101	T30247	T30383	themeOf	STAT3,activated
R16102	T30247	T30384	themeOf	STAT3,induced
R16104	T30248	T30384	causeOf	IL-6,induced
R16105	T30249	T30385	themeOf	STAT3,activation
R16106	T30159	T30344	themeOf	CD80,express
R16107	T30250	T30386	themeOf	IL-6,production
R16108	T30162	T30346	themeOf	CD28,phosphorylation
R16109	T30259	T30387	themeOf	STAT3,activation
R16110	T30164	T30350	themeOf	IL-10,defective
R16111	T30164	T30349	themeOf	IL-10,inhibition
R16112	T30165	T30347	themeOf	CD28,costimulated
R16113	T30166	T30348	themeOf	IFN-γ,production
R16114	T30167	T30348	themeOf	IL-2,production
R16115	T30168	T30351	themeOf	IL-10,produced
R16116	T30261	T30388	themeOf	SOCS1,expressed
R16117	T30176	T30352	themeOf	STAT3,activation
R16118	T30178	T30357	themeOf	IL-10R1,expression
R16119	T30264	T30389	themeOf	SOCS1,binding
R16120	T30180	T30355	themeOf	Jak1,activation
R16121	T30183	T30358	themeOf	IL-10R1,decreased
R16122	T30265	T30390	themeOf	SOCS3,binding
R16123	T30267	T30391	themeOf	SOCS1,induced
R16124	T30190	T30361	themeOf	STAT3,activation
R16125	T30191	T30359	themeOf	IL-10R1,expression
R16126	T30268	T30391	themeOf	SOCS3,induced
R16127	T30194	T30363	themeOf	STAT3,activation
R16128	T30271	T30392	themeOf	SOCS3,lacking
R16129	T30195	T30362	themeOf	STAT3,phosphorylated
R16130	T30197	T30364	themeOf	STAT3,activated
R16131	T30272	T30392	themeOf	SOCS1,lacking
R16132	T30202	T30364	themeOf	IL-10,activated
R16133	T30276	T30395	themeOf	SOCS3,deficient
R16134	T30277	T30394	themeOf	SOCS3,deficiency
R16135	T30209	T30365	themeOf	STAT3,activation
R16136	T30210	T30366	themeOf	IL-10,inhibition
R16137	T30278	T30397	themeOf	SOCS1,deficiency
R16138	T30213	T30368	themeOf	STAT3,induced
R16139	T30279	T30393	themeOf	STAT3,activation
R16140	T30215	T30369	themeOf	IL-10,secretion
R16141	T30280	T30396	themeOf	IL-6,response
R16142	T30218	T30370	themeOf	IL-10,producing
R16143	T30281	T30400	themeOf	SOCS3,deficient
R16144	T30220	T30371	themeOf	IL-10,induced
R16145	T30282	T30398	themeOf	SOCS3,inhibitor
R16146	T30283	T30399	themeOf	IL-6,induced
R16147	T30284	T30401	themeOf	SOCS3,dispensable
R16148	T30288	T30408	themeOf	SOCS1,expression
R16149	T30318	T30420	themeOf	SOCS3,express
R16150	T30319	T30421	themeOf	SOCS3,expression
R16151	T30320	T30423	themeOf	SOCS1,expression
R16152	T30292	T30402	themeOf	STAT3,activation
R16153	T30321	T30424	themeOf	SOCS3,expression
R16154	T30326	T30325	themeOf	phosphorylation,inhibits
R16155	T30293	T30403	themeOf	SOCS3,expression
R16156	T30294	T30406	themeOf	STAT3,activation
R16159	T30296	T30409	themeOf	SOCS1,induction
R16164	T30298	T30411	themeOf	IFN-γ,produce
R16165	T30303	T30410	themeOf	SOCS1,inducer
R16167	T30343	T30341	themeOf	activation,impaired
R16168	T30304	T30412	themeOf	SOCS1,express
R16169	T30346	T30345	themeOf	phosphorylation,inhibiting
R16170	T30305	T30412	themeOf	SOCS3,express
R16171	T30348	T30349	themeOf	production,inhibition
R16172	T30348	T30349	themeOf	production,inhibition
R16173	T30348	T30347	themeOf	production,costimulated
R16174	T30348	T30347	themeOf	production,costimulated
R16175	T30306	T30415	causeOf	IL-12,induced
R16176	T30352	T30353	themeOf	activation,mediated
R16177	T30307	T30417	themeOf	STAT4,activation
R16178	T30355	T30356	themeOf	activation,induced
R16179	T30355	T30354	themeOf	activation,suppressed
R16180	T30308	T30416	themeOf	SOCS3,induction
R16181	T30357	T30354	themeOf	expression,suppressed
R16182	T30309	T30414	themeOf	IL-4,induced
R16183	T30361	T30360	themeOf	activation,defective
R16184	T30311	T30413	themeOf	SOCS1,induction
R16185	T30365	T30367	themeOf	activation,induced
R16186	T30413	T30419	themeOf	induction,diminished
R16187	T30369	T30368	themeOf	secretion,induced
R16188	T30374	T30375	themeOf	inhibition,reduced
R16189	T30377	T30378	themeOf	activation,stimulate
R16190	T30381	T30382	themeOf	expression,activation
R16191	T30381	T30382	themeOf	expression,activation
R16192	T30417	T30418	themeOf	activation,inhibited
R16193	T30417	T30415	themeOf	activation,induced
R16194	T30423	T30422	themeOf	expression,Higher
R16195	T30403	T30405	themeOf	expression,defective
R16196	T30403	T30404	themeOf	expression,responsible
R16197	T30406	T30404	themeOf	activation,responsible
R16198	T30408	T30407	themeOf	expression,Increased
R16103	T30156	T30342	themeOf	SOCS1,induction
R16079	T30132	T30334	themeOf	IL-10R1,expression
R16080	T30133	T30328	themeOf	STAT3,activation
R16081	T30134	T30331	causeOf	IL-10,induced
R16082	T30134	T30331	causeOf	IL-10,induced
R16084	T30135	T30331	themeOf	STAT3,induced
R16085	T30135	T30329	themeOf	STAT3,phosphorylation
R16086	T30138	T30333	themeOf	STAT3,phosphorylation
R16157	T30329	T30331	themeOf	phosphorylation,induced
R16158	T30329	T30330	themeOf	phosphorylation,suppressed
R16160	T30333	T30332	themeOf	phosphorylation,inducible
R16161	T30334	T30330	themeOf	expression,suppressed
R16087	T30139	T30332	causeOf	IL-10,inducible
R16088	T30140	T30338	causeOf	IL-6,induces
R16089	T30140	T30338	causeOf	IL-6,induces
R16090	T30141	T30335	themeOf	STAT3,phosphorylation
R16092	T30142	T30335	themeOf	STAT1,phosphorylation
R16093	T30144	T30337	themeOf	IL-6,induces
R16094	T30145	T30336	themeOf	IL-10,inhibition
R16095	T30146	T30339	themeOf	IFN-γ,production
R16162	T30335	T30338	themeOf	phosphorylation,induces
R16163	T30335	T30338	themeOf	phosphorylation,induces
R16166	T30339	T30336	themeOf	production,inhibition

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T26758	8533-8542	Transcription	denotes	expressed
T26757	8335-8343	Positive_regulation	denotes	mediated
T26756	8350-8360	Positive_regulation	denotes	activation
T26755	7599-7609	Positive_regulation	denotes	activation
T26754	7686-7696	Gene_expression	denotes	production
T26753	7631-7639	Positive_regulation	denotes	involved
T26744	6800-6810	Positive_regulation	denotes	activation
T26743	6580-6588	Gene_expression	denotes	produced
T26742	6448-6455	Negative_regulation	denotes	reduced
T26741	6402-6410	Positive_regulation	denotes	mediated
T26740	6417-6427	Negative_regulation	denotes	inhibition
T26739	6122-6131	Positive_regulation	denotes	augmented
T26738	6012-6019	Positive_regulation	denotes	induced
T26737	5894-5903	Gene_expression	denotes	producing
T26736	5736-5743	Positive_regulation	denotes	induced
T26735	5779-5788	Localization	denotes	secretion
T26734	5504-5514	Positive_regulation	denotes	activation
T26733	5586-5593	Positive_regulation	denotes	induced
T26732	5543-5553	Negative_regulation	denotes	inhibition
T26731	4850-4859	Positive_regulation	denotes	activated
T26730	4678-4686	Positive_regulation	denotes	mediated
T26729	4693-4703	Positive_regulation	denotes	activation
T26728	4663-4671	Negative_regulation	denotes	impaired
T26727	4479-4486	Regulation	denotes	effects
T26726	4558-4567	Regulation	denotes	modulated
T26725	4456-4466	Gene_expression	denotes	expression
T26724	4407-4416	Regulation	denotes	dependent
T26723	4423-4433	Positive_regulation	denotes	activation
T26722	4391-4400	Negative_regulation	denotes	defective
T26721	4122-4131	Negative_regulation	denotes	decreased
T26720	4132-4141	Localization	denotes	transport
T26719	4099-4105	Regulation	denotes	effect
T26718	3860-3870	Positive_regulation	denotes	activation
T26717	3847-3854	Positive_regulation	denotes	induced
T26716	3826-3836	Gene_expression	denotes	expression
T26715	3875-3885	Negative_regulation	denotes	suppressed
T26714	3616-3624	Positive_regulation	denotes	mediated
T26713	3631-3641	Positive_regulation	denotes	activation
T26712	3469-3476	Positive_regulation	denotes	induced
T26711	3184-3192	Gene_expression	denotes	produced
T26710	2939-2949	Gene_expression	denotes	production
T26709	2891-2900	Negative_regulation	denotes	defective
T26708	2926-2938	Positive_regulation	denotes	costimulated
T26707	2907-2917	Negative_regulation	denotes	inhibition
T26706	2768-2783	Phosphorylation	denotes	phosphorylation
T26705	2743-2753	Negative_regulation	denotes	inhibiting
T26704	2246-2255	Positive_regulation	denotes	induction
T26703	2156-2165	Regulation	denotes	dependent
T26702	2125-2137	Positive_regulation	denotes	attributable
T26701	2204-2213	Positive_regulation	denotes	sustained
T26700	2141-2149	Negative_regulation	denotes	impaired
T26699	2220-2235	Phosphorylation	denotes	phosphorylation
T26698	2172-2182	Positive_regulation	denotes	activation
T26697	1901-1912	Transcription	denotes	transcripts
T26696	1756-1763	Positive_regulation	denotes	induces
T26695	1808-1818	Gene_expression	denotes	production
T26694	1768-1778	Positive_regulation	denotes	resistance
T26693	1741-1750	Positive_regulation	denotes	exogenous
T26692	1788-1798	Negative_regulation	denotes	inhibition
T26691	1697-1712	Phosphorylation	denotes	phosphorylation
T26690	1669-1676	Positive_regulation	denotes	induces
T26689	1585-1600	Phosphorylation	denotes	phosphorylation
T26688	1443-1453	Positive_regulation	denotes	activation
T26687	1506-1516	Negative_regulation	denotes	suppressed
T26686	1478-1493	Phosphorylation	denotes	phosphorylation
T26685	1409-1419	Gene_expression	denotes	expression
T26684	1621-1630	Positive_regulation	denotes	inducible
T26683	1461-1468	Positive_regulation	denotes	induced
T26682	1292-1299	Gene_expression	denotes	produce
T26681	1001-1009	Negative_regulation	denotes	inhibits
T26680	666-676	Binding	denotes	engagement
T26679	554-563	Gene_expression	denotes	expressed
T26678	10959-10962	Protein	denotes	CD4
T26677	10936-10941	Protein	denotes	SOCS3
T26676	10908-10913	Protein	denotes	SOCS1
T26675	10818-10823	Protein	denotes	SOCS3
T26674	10791-10796	Protein	denotes	SOCS3
T26673	10637-10642	Protein	denotes	STAT4
T26672	10631-10636	Protein	denotes	IL-12
T26671	10617-10622	Protein	denotes	STAT6
T26670	10612-10616	Protein	denotes	IL-4
T26669	10493-10498	Protein	denotes	SOCS3
T26668	10483-10488	Protein	denotes	SOCS1
T26667	10453-10458	Protein	denotes	SOCS1
T26666	10420-10425	Protein	denotes	STAT6
T26665	10407-10411	Protein	denotes	IL-4
T26664	10369-10374	Protein	denotes	SOCS3
T26663	10336-10341	Protein	denotes	STAT4
T26662	10322-10327	Protein	denotes	IL-12
T26661	10291-10296	Protein	denotes	SOCS3
T26660	10281-10286	Protein	denotes	SOCS1
T26659	10168-10173	Protein	denotes	SOCS1
T26658	10124-10129	Protein	denotes	IFN-γ
T26657	10105-10110	Protein	denotes	IL-10
T26656	10080-10085	Protein	denotes	IFN-γ
T26655	10023-10026	Protein	denotes	CD4
T26654	10008-10013	Protein	denotes	IFN-γ
T26653	9984-9987	Protein	denotes	CD4
T26652	9930-9935	Protein	denotes	SOCS1
T26651	9896-9900	Protein	denotes	IL-6
T26650	9858-9863	Protein	denotes	STAT3
T26649	9807-9812	Protein	denotes	SOCS3
T26648	9775-9780	Protein	denotes	STAT3
T26647	9760-9765	Protein	denotes	IL-10
T26646	9747-9752	Protein	denotes	IL-10
T26645	9665-9668	Protein	denotes	CD4
T26644	9642-9647	Protein	denotes	SOCS1
T26643	9601-9606	Protein	denotes	IL-10
T26642	9565-9570	Protein	denotes	SOCS1
T26641	9521-9526	Protein	denotes	IL-10
T26640	9423-9428	Protein	denotes	SOCS3
T26636	9258-9262	Protein	denotes	IL-6
T26635	9237-9242	Protein	denotes	STAT3
T26634	9184-9189	Protein	denotes	SOCS1
T26633	9158-9163	Protein	denotes	SOCS3
T26632	9121-9126	Protein	denotes	SOCS3
T26631	9081-9086	Protein	denotes	IL-10
T26630	9055-9059	Protein	denotes	IL-6
T26629	9022-9027	Protein	denotes	SOCS3
T26628	9002-9007	Protein	denotes	SOCS1
T26627	8993-8998	Protein	denotes	SOCS3
T26626	8889-8894	Protein	denotes	IL-10
T26625	8880-8884	Protein	denotes	IL-6
T26624	8830-8835	Protein	denotes	SOCS3
T26623	8820-8825	Protein	denotes	SOCS1
T26622	8808-8813	Protein	denotes	gp130
T26621	8694-8699	Protein	denotes	SOCS3
T26620	8629-8634	Protein	denotes	SOCS1
T26619	8615-8618	Protein	denotes	CD4
T26618	8587-8592	Protein	denotes	SOCS3
T26617	8560-8565	Protein	denotes	SOCS1
T26616	8491-8494	Protein	denotes	CD4
T26615	8344-8349	Protein	denotes	STAT3
T26614	8329-8334	Protein	denotes	gp130
T26613	8228-8231	Protein	denotes	CD4
T26612	8181-8186	Protein	denotes	gp130
T26611	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T26610	8038-8043	Protein	denotes	gp130
T26609	7961-7966	Protein	denotes	gp130
T26608	7865-7870	Protein	denotes	STAT3
T26607	7719-7724	Protein	denotes	STAT3
T26606	7681-7685	Protein	denotes	IL-6
T26605	7593-7598	Protein	denotes	STAT3
T26604	7553-7557	Protein	denotes	IL-6
T26603	7514-7519	Protein	denotes	STAT3
T26602	7445-7453	Protein	denotes	type III
T26601	7416-7440	Protein	denotes	Fc gamma receptor type I
T26600	7269-7274	Protein	denotes	STAT3
T26599	7251-7255	Protein	denotes	IL-6
T26598	7158-7163	Protein	denotes	STAT3
T26597	7087-7092	Protein	denotes	STAT3
T26596	6928-6933	Protein	denotes	IL-10
T26595	6874-6879	Protein	denotes	IL-10
T26594	6832-6837	Protein	denotes	SOCS1
T26593	6815-6820	Protein	denotes	IFN-γ
T26592	6794-6799	Protein	denotes	STAT3
T26591	6761-6766	Protein	denotes	IL-10
T26590	6650-6655	Protein	denotes	IL-10
T26589	6592-6595	Protein	denotes	CD4
T26588	6574-6579	Protein	denotes	IL-10
T26587	6564-6569	Protein	denotes	IFN-γ
T26586	6528-6532	Protein	denotes	IL-6
T26585	6487-6492	Protein	denotes	TNF-α
T26584	6477-6482	Protein	denotes	IL-1β
T26583	6431-6434	Protein	denotes	CD4
T26582	6411-6416	Protein	denotes	IFN-γ
T26581	6396-6401	Protein	denotes	IL-10
T26580	6178-6182	Protein	denotes	IL-6
T26579	6104-6109	Protein	denotes	IL-10
T26578	6088-6091	Protein	denotes	CD4
T26577	6020-6025	Protein	denotes	STAT3
T26576	6006-6011	Protein	denotes	IL-10
T26575	5938-5941	Protein	denotes	CD4
T26574	5926-5931	Protein	denotes	IL-10
T26573	5856-5859	Protein	denotes	CD4
T26572	5838-5843	Protein	denotes	IL-10
T26571	5773-5778	Protein	denotes	IL-10
T26570	5747-5750	Protein	denotes	CD4
T26569	5697-5702	Protein	denotes	STAT3
T26568	5657-5661	Protein	denotes	IL-6
T26567	5566-5569	Protein	denotes	CD4
T26566	5537-5542	Protein	denotes	IL-10
T26565	5498-5503	Protein	denotes	STAT3
T26564	5446-5450	Protein	denotes	IL-6
T26563	5399-5402	Protein	denotes	CD4
T26562	5368-5373	Protein	denotes	IL-10
T26561	5272-5277	Protein	denotes	STAT3
T26560	5253-5257	Protein	denotes	IL-6
T26559	5055-5059	Protein	denotes	IL-6
T26558	5024-5029	Protein	denotes	IL-10
T26557	4975-4987	Protein	denotes	oncostatin M
T26556	4943-4969	Protein	denotes	leukemia inhibitory factor
T26555	4936-4941	Protein	denotes	IL-11
T26554	4930-4934	Protein	denotes	IL-6
T26553	4841-4846	Protein	denotes	STAT3
T26552	4810-4813	Protein	denotes	CD4
T26551	4705-4710	Protein	denotes	STAT3
T26550	4687-4692	Protein	denotes	STAT3
T26549	4672-4677	Protein	denotes	IL-10
T26548	4490-4495	Protein	denotes	IL-10
T26547	4448-4455	Protein	denotes	IL-10R1
T26546	4417-4422	Protein	denotes	STAT3
T26545	4401-4406	Protein	denotes	IL-10
T26544	4362-4367	Protein	denotes	IL-10
T26543	4346-4349	Protein	denotes	CD4
T26798	10942-10952	Gene_expression	denotes	expression
T26797	10901-10907	Positive_regulation	denotes	Higher
T26796	10914-10924	Gene_expression	denotes	expression
T26795	10930-10935	Positive_regulation	denotes	lower
T26794	10824-10834	Gene_expression	denotes	expression
T26793	10375-10384	Positive_regulation	denotes	induction
T26792	10342-10352	Positive_regulation	denotes	activation
T26791	10328-10335	Positive_regulation	denotes	induced
T26790	10356-10365	Negative_regulation	denotes	inhibited
T26789	10412-10419	Positive_regulation	denotes	induced
T26788	10439-10449	Negative_regulation	denotes	diminished
T26787	10459-10468	Positive_regulation	denotes	induction
T26786	10258-10265	Gene_expression	denotes	express
T26785	10157-10164	Positive_regulation	denotes	inducer
T26784	9936-9945	Positive_regulation	denotes	induction
T26783	10057-10064	Gene_expression	denotes	produce
T26782	10000-10007	Gene_expression	denotes	produce
T26781	9953-9963	Regulation	denotes	associated
T26780	9813-9823	Gene_expression	denotes	expression
T26779	9766-9774	Positive_regulation	denotes	mediated
T26778	9864-9874	Positive_regulation	denotes	activation
T26777	9781-9791	Positive_regulation	denotes	activation
T26776	9648-9658	Gene_expression	denotes	expression
T26775	9831-9842	Positive_regulation	denotes	responsible
T26774	9797-9806	Negative_regulation	denotes	defective
T26773	9632-9641	Positive_regulation	denotes	Increased
T26772	9432-9443	Negative_regulation	denotes	dispensable
T26771	9353-9362	Negative_regulation	denotes	inhibitor
T26770	9375-9382	Positive_regulation	denotes	induced
T26769	9293-9302	Negative_regulation	denotes	deficient
T26768	9246-9254	Positive_regulation	denotes	response
T26767	9190-9200	Negative_regulation	denotes	deficiency
T26766	9127-9136	Negative_regulation	denotes	deficient
T26765	9164-9174	Negative_regulation	denotes	deficiency
T26764	9223-9233	Positive_regulation	denotes	activation
T26763	8985-8992	Negative_regulation	denotes	lacking
T26762	8840-8847	Positive_regulation	denotes	induced
T26761	8674-8681	Binding	denotes	binding
T26760	8700-8708	Negative_regulation	denotes	inhibits
T26759	8730-8737	Binding	denotes	binding
T26542	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T26541	4234-4238	Protein	denotes	IL-1
T26540	4227-4232	Protein	denotes	TNF-α
T26539	4159-4166	Protein	denotes	IL-10R1
T26538	4109-4114	Protein	denotes	IL-10
T26537	3889-3894	Protein	denotes	IFN-γ
T26536	3855-3859	Protein	denotes	Jak1
T26535	3841-3846	Protein	denotes	IL-10
T26534	3818-3825	Protein	denotes	IL-10R1
T26533	3707-3712	Protein	denotes	IL-10
T26532	3625-3630	Protein	denotes	STAT3
T26531	3610-3615	Protein	denotes	IL-10
T26530	3509-3513	Protein	denotes	Jak1
T26529	3490-3494	Protein	denotes	IL-1
T26528	3480-3485	Protein	denotes	TNF-α
T26527	3558-3562	Protein	denotes	IL-6
T26526	3548-3553	Protein	denotes	IL-10
T26525	3514-3519	Protein	denotes	STAT3
T26524	3177-3182	Protein	denotes	IL-10
T26523	2968-2972	Protein	denotes	IL-2
T26522	2958-2963	Protein	denotes	IFN-γ
T26521	2921-2925	Protein	denotes	CD28
T26520	2901-2906	Protein	denotes	IL-10
T26519	2869-2872	Protein	denotes	CD4
T26518	2754-2758	Protein	denotes	CD28
T26477	493-497	Protein	denotes	CD86
T26476	484-488	Protein	denotes	CD80
T26475	465-469	Protein	denotes	CD28
T26474	414-418	Protein	denotes	CD28
T26473	333-336	Protein	denotes	CD4
T26472	101-104	Protein	denotes	CD4
T26471	11-14	Protein	denotes	CD4
T26517	2664-2669	Protein	denotes	IL-10
T26516	2595-2599	Protein	denotes	CD86
T26515	2586-2590	Protein	denotes	CD80
T26514	2286-2289	Protein	denotes	CD4
T26513	2257-2262	Protein	denotes	IL-10
T26512	2240-2245	Protein	denotes	SOCS1
T26511	2214-2219	Protein	denotes	STAT3
T26510	2166-2171	Protein	denotes	STAT3
T26509	2150-2155	Protein	denotes	IL-10
T26508	2040-2045	Protein	denotes	IL-10
T26507	1982-1985	Protein	denotes	CD4
T26506	1939-1942	Protein	denotes	CD4
T26505	1895-1900	Protein	denotes	SOCS3
T26504	1861-1866	Protein	denotes	SOCS1
T26503	1823-1826	Protein	denotes	CD4
T26502	1802-1807	Protein	denotes	IFN-γ
T26501	1782-1787	Protein	denotes	IL-10
T26500	1751-1755	Protein	denotes	IL-6
T26499	1723-1726	Protein	denotes	CD4
T26498	1691-1696	Protein	denotes	STAT1
T26497	1677-1682	Protein	denotes	STAT3
T26496	1647-1651	Protein	denotes	IL-6
T26495	1634-1639	Protein	denotes	IL-10
T26494	1579-1584	Protein	denotes	STAT3
T26493	1559-1562	Protein	denotes	CD4
T26492	1523-1526	Protein	denotes	CD4
T26491	1497-1502	Protein	denotes	STAT3
T26490	1455-1460	Protein	denotes	IL-10
T26489	1437-1442	Protein	denotes	STAT3
T26488	1401-1408	Protein	denotes	IL-10R1
T26487	1368-1371	Protein	denotes	CD4
T26486	1337-1341	Protein	denotes	CD28
T26485	1317-1322	Protein	denotes	IFN-γ
T26484	1273-1278	Protein	denotes	IL-10
T26483	1211-1214	Protein	denotes	CD4
T26482	1046-1050	Protein	denotes	CD28
T26481	995-1000	Protein	denotes	IL-10
T26480	852-857	Protein	denotes	IL-10
T26479	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T26478	661-665	Protein	denotes	CD28
T26639	9370-9374	Protein	denotes	IL-6
T26638	9334-9339	Protein	denotes	SOCS3
T26637	9287-9292	Protein	denotes	SOCS3
T26752	7535-7542	Positive_regulation	denotes	induced
T26751	7504-7513	Positive_regulation	denotes	activated
T26750	7398-7408	Gene_expression	denotes	expression
T26749	7182-7191	Gene_expression	denotes	expressed
T26748	7093-7103	Positive_regulation	denotes	activation
T26747	6918-6924	Regulation	denotes	effect
T26746	6951-6960	Regulation	denotes	modulated
T26745	6784-6793	Positive_regulation	denotes	stimulate
R13449	T26476	T26679	themeOf	CD80,expressed
R13450	T26478	T26680	themeOf	CD28,engagement
R13451	T26481	T26681	themeOf	IL-10,inhibits
R13452	T26485	T26682	themeOf	IFN-γ,produce
R13453	T26488	T26685	themeOf	IL-10R1,expression
R13454	T26489	T26688	themeOf	STAT3,activation
R13455	T26490	T26683	causeOf	IL-10,induced
R13456	T26491	T26686	themeOf	STAT3,phosphorylation
R13457	T26494	T26689	themeOf	STAT3,phosphorylation
R13458	T26496	T26690	causeOf	IL-6,induces
R13459	T26545	T26724	causeOf	IL-10,dependent
R13460	T26496	T26690	causeOf	IL-6,induces
R13461	T26546	T26723	themeOf	STAT3,activation
R13462	T26497	T26691	themeOf	STAT3,phosphorylation
R13463	T26547	T26725	themeOf	IL-10R1,expression
R13464	T26498	T26691	themeOf	STAT1,phosphorylation
R13465	T26548	T26726	themeOf	IL-10,modulated
R13466	T26548	T26727	themeOf	IL-10,effects
R13467	T26500	T26693	themeOf	IL-6,exogenous
R13468	T26500	T26696	causeOf	IL-6,induces
R13469	T26550	T26729	themeOf	STAT3,activation
R13470	T26500	T26696	causeOf	IL-6,induces
R13471	T26501	T26692	themeOf	IL-10,inhibition
R13472	T26553	T26731	themeOf	STAT3,activated
R13473	T26502	T26695	themeOf	IFN-γ,production
R13474	T26505	T26697	themeOf	SOCS3,transcripts
R13475	T26558	T26731	themeOf	IL-10,activated
R13476	T26509	T26703	causeOf	IL-10,dependent
R13477	T26510	T26698	themeOf	STAT3,activation
R13478	T26565	T26734	themeOf	STAT3,activation
R13479	T26511	T26699	themeOf	STAT3,phosphorylation
R13480	T26566	T26732	themeOf	IL-10,inhibition
R13481	T26512	T26704	themeOf	SOCS1,induction
R13482	T26517	T26705	causeOf	IL-10,inhibiting
R13483	T26571	T26735	themeOf	IL-10,secretion
R13484	T26518	T26706	themeOf	CD28,phosphorylation
R13485	T26574	T26737	themeOf	IL-10,producing
R13486	T26520	T26709	themeOf	IL-10,defective
R13487	T26576	T26738	themeOf	IL-10,induced
R13488	T26521	T26708	themeOf	CD28,costimulated
R13489	T26522	T26710	themeOf	IFN-γ,production
R13490	T26579	T26739	themeOf	IL-10,augmented
R13491	T26523	T26710	themeOf	IL-2,production
R13492	T26524	T26711	themeOf	IL-10,produced
R13493	T26582	T26740	themeOf	IFN-γ,inhibition
R13494	T26528	T26712	themeOf	TNF-α,induced
R13495	T26529	T26712	causeOf	IL-1,induced
R13496	T26587	T26743	themeOf	IFN-γ,produced
R13497	T26532	T26713	themeOf	STAT3,activation
R13498	T26588	T26743	themeOf	IL-10,produced
R13499	T26534	T26716	themeOf	IL-10R1,expression
R13500	T26592	T26744	themeOf	STAT3,activation
R13501	T26535	T26717	causeOf	IL-10,induced
R13502	T26536	T26718	themeOf	Jak1,activation
R13503	T26596	T26747	themeOf	IL-10,effect
R13504	T26538	T26719	themeOf	IL-10,effect
R13505	T26597	T26748	themeOf	STAT3,activation
R13506	T26539	T26720	themeOf	IL-10R1,transport
R13507	T26598	T26749	themeOf	STAT3,expressed
R13508	T26637	T26769	themeOf	SOCS3,deficient
R13509	T26601	T26750	themeOf	Fc gamma receptor type I,expression
R13510	T26638	T26771	themeOf	SOCS3,inhibitor
R13511	T26602	T26750	themeOf	type III,expression
R13512	T26639	T26770	themeOf	IL-6,induced
R13513	T26603	T26751	themeOf	STAT3,activated
R13514	T26603	T26752	themeOf	STAT3,induced
R13515	T26640	T26772	themeOf	SOCS3,dispensable
R13516	T26604	T26752	causeOf	IL-6,induced
R13517	T26644	T26776	themeOf	SOCS1,expression
R13518	T26605	T26755	themeOf	STAT3,activation
R13519	T26606	T26754	themeOf	IL-6,production
R13520	T26648	T26777	themeOf	STAT3,activation
R13521	T26649	T26780	themeOf	SOCS3,expression
R13522	T26650	T26778	themeOf	STAT3,activation
R13523	T26652	T26784	themeOf	SOCS1,induction
R13524	T26615	T26756	themeOf	STAT3,activation
R13525	T26654	T26782	themeOf	IFN-γ,produce
R13526	T26617	T26758	themeOf	SOCS1,expressed
R13527	T26618	T26758	themeOf	SOCS3,expressed
R13528	T26656	T26783	themeOf	IFN-γ,produce
R13529	T26620	T26761	themeOf	SOCS1,binding
R13530	T26659	T26785	themeOf	SOCS1,inducer
R13531	T26621	T26760	themeOf	SOCS3,inhibits
R13532	T26621	T26759	themeOf	SOCS3,binding
R13533	T26660	T26786	themeOf	SOCS1,express
R13534	T26661	T26786	themeOf	SOCS3,express
R13535	T26622	T26759	themeOf	gp130,binding
R13536	T26662	T26791	causeOf	IL-12,induced
R13537	T26623	T26762	themeOf	SOCS1,induced
R13538	T26663	T26792	themeOf	STAT4,activation
R13539	T26624	T26762	themeOf	SOCS3,induced
R13540	T26664	T26793	themeOf	SOCS3,induction
R13541	T26665	T26789	themeOf	IL-4,induced
R13542	T26627	T26763	themeOf	SOCS3,lacking
R13543	T26667	T26787	themeOf	SOCS1,induction
R13544	T26628	T26763	themeOf	SOCS1,lacking
R13545	T26675	T26794	themeOf	SOCS3,expression
R13546	T26632	T26766	themeOf	SOCS3,deficient
R13547	T26633	T26765	themeOf	SOCS3,deficiency
R13548	T26676	T26796	themeOf	SOCS1,expression
R13549	T26634	T26767	themeOf	SOCS1,deficiency
R13550	T26677	T26798	themeOf	SOCS3,expression
R13551	T26635	T26764	themeOf	STAT3,activation
R13552	T26686	T26683	themeOf	phosphorylation,induced
R13553	T26636	T26768	themeOf	IL-6,response
R13554	T26734	T26733	themeOf	activation,induced
R13555	T26686	T26687	themeOf	phosphorylation,suppressed
R13556	T26689	T26684	themeOf	phosphorylation,inducible
R13557	T26735	T26736	themeOf	secretion,induced
R13558	T26691	T26690	themeOf	phosphorylation,induces
R13559	T26740	T26741	themeOf	inhibition,mediated
R13560	T26691	T26690	themeOf	phosphorylation,induces
R13561	T26692	T26694	themeOf	inhibition,resistance
R13562	T26740	T26742	themeOf	inhibition,reduced
R13563	T26692	T26694	themeOf	inhibition,resistance
R13564	T26694	T26696	themeOf	resistance,induces
R13565	T26744	T26745	themeOf	activation,stimulate
R13566	T26694	T26696	themeOf	resistance,induces
R13567	T26695	T26692	themeOf	production,inhibition
R13568	T26698	T26702	themeOf	activation,attributable
R13569	T26747	T26746	themeOf	effect,modulated
R13570	T26698	T26700	themeOf	activation,impaired
R13571	T26698	T26703	themeOf	activation,dependent
R13572	T26699	T26701	themeOf	phosphorylation,sustained
R13573	T26706	T26705	themeOf	phosphorylation,inhibiting
R13574	T26754	T26753	themeOf	production,involved
R13575	T26756	T26757	themeOf	activation,mediated
R13576	T26710	T26707	themeOf	production,inhibition
R13577	T26759	T26760	causeOf	binding,inhibits
R13578	T26710	T26707	themeOf	production,inhibition
R13579	T26710	T26708	themeOf	production,costimulated
R13580	T26710	T26708	themeOf	production,costimulated
R13581	T26713	T26714	themeOf	activation,mediated
R13582	T26716	T26715	themeOf	expression,suppressed
R13583	T26718	T26717	themeOf	activation,induced
R13584	T26776	T26773	themeOf	expression,Increased
R13585	T26718	T26715	themeOf	activation,suppressed
R13586	T26720	T26721	themeOf	transport,decreased
R13587	T26777	T26779	themeOf	activation,mediated
R13588	T26778	T26775	themeOf	activation,responsible
R13589	T26723	T26722	themeOf	activation,defective
R13590	T26780	T26774	themeOf	expression,defective
R13591	T26723	T26724	themeOf	activation,dependent
R13592	T26780	T26775	causeOf	expression,responsible
R13593	T26729	T26728	themeOf	activation,impaired
R13594	T26782	T26781	themeOf	produce,associated
R13595	T26784	T26781	themeOf	induction,associated
R13596	T26729	T26730	themeOf	activation,mediated
R13598	T26787	T26788	themeOf	induction,diminished
R13600	T26792	T26790	themeOf	activation,inhibited
R13602	T26792	T26791	themeOf	activation,induced
R13604	T26793	T26790	themeOf	induction,inhibited
R13607	T26796	T26797	themeOf	expression,Higher
R13609	T26798	T26795	themeOf	expression,lower

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T28838	6918-6924	Regulation	denotes	effect
T28837	6784-6793	Positive_regulation	denotes	stimulate
T28836	6800-6810	Positive_regulation	denotes	activation
T28835	6625-6636	Positive_regulation	denotes	responsible
T28834	6580-6588	Gene_expression	denotes	produced
T28833	6402-6410	Positive_regulation	denotes	mediated
T28832	6459-6471	Binding	denotes	pretreatment
T28831	6417-6427	Negative_regulation	denotes	inhibition
T28830	6122-6131	Positive_regulation	denotes	augmented
T28829	5894-5903	Gene_expression	denotes	producing
T28828	5779-5788	Localization	denotes	secretion
T28827	5736-5743	Positive_regulation	denotes	induced
T28826	5523-5533	Positive_regulation	denotes	resistance
T28825	5488-5497	Positive_regulation	denotes	sustained
T28824	5586-5593	Positive_regulation	denotes	induced
T28823	5543-5553	Negative_regulation	denotes	inhibition
T28822	5504-5514	Positive_regulation	denotes	activation
T28821	5278-5288	Positive_regulation	denotes	activating
T28820	4850-4859	Positive_regulation	denotes	activated
T28819	4678-4686	Positive_regulation	denotes	mediated
T28818	4663-4671	Negative_regulation	denotes	impaired
T28817	4736-4750	Phosphorylation	denotes	phosphorylated
T28816	4693-4703	Positive_regulation	denotes	activation
T28815	4646-4657	Binding	denotes	association
T28814	4558-4567	Regulation	denotes	modulated
T28813	4375-4385	Positive_regulation	denotes	associated
T28812	4456-4466	Gene_expression	denotes	expression
T28811	4423-4433	Positive_regulation	denotes	activation
T28810	3826-3836	Gene_expression	denotes	expression
T28809	3616-3624	Positive_regulation	denotes	mediated
T28808	3631-3641	Positive_regulation	denotes	activation
T28807	3184-3192	Gene_expression	denotes	produced
T28806	2926-2938	Positive_regulation	denotes	costimulated
T28805	2907-2917	Negative_regulation	denotes	inhibition
T28804	2939-2949	Gene_expression	denotes	production
T28803	2891-2900	Negative_regulation	denotes	defective
T28802	2743-2753	Negative_regulation	denotes	inhibiting
T28801	2768-2783	Phosphorylation	denotes	phosphorylation
T28800	2552-2559	Gene_expression	denotes	express
T28799	2263-2271	Positive_regulation	denotes	mediated
T28798	2272-2282	Negative_regulation	denotes	inhibition
T28797	2307-2317	Gene_expression	denotes	production
T28796	2204-2213	Positive_regulation	denotes	sustained
T28795	2246-2255	Positive_regulation	denotes	induction
T28794	2220-2235	Phosphorylation	denotes	phosphorylation
T28793	2172-2182	Positive_regulation	denotes	activation
T28792	1879-1884	Positive_regulation	denotes	lower
T28791	1901-1912	Transcription	denotes	transcripts
T28790	1844-1850	Positive_regulation	denotes	higher
T28789	1756-1763	Positive_regulation	denotes	induces
T28788	1768-1778	Positive_regulation	denotes	resistance
T28787	1788-1798	Negative_regulation	denotes	inhibition
T28786	1669-1676	Positive_regulation	denotes	induces
T28785	1808-1818	Gene_expression	denotes	production
T28784	1697-1712	Phosphorylation	denotes	phosphorylation
T28783	1461-1468	Positive_regulation	denotes	induced
T28782	1390-1400	Positive_regulation	denotes	high-level
T28781	1621-1630	Positive_regulation	denotes	inducible
T28780	1585-1600	Phosphorylation	denotes	phosphorylation
T28779	1478-1493	Phosphorylation	denotes	phosphorylation
T28778	1409-1419	Gene_expression	denotes	expression
T28777	1292-1299	Gene_expression	denotes	produce
T28776	1001-1009	Negative_regulation	denotes	inhibits
T28775	1023-1038	Phosphorylation	denotes	phosphorylation
T28774	666-676	Binding	denotes	engagement
T28773	554-563	Gene_expression	denotes	expressed
T28772	10959-10962	Protein	denotes	CD4
T28771	10936-10941	Protein	denotes	SOCS3
T28770	10908-10913	Protein	denotes	SOCS1
T28769	10818-10823	Protein	denotes	SOCS3
T28768	10791-10796	Protein	denotes	SOCS3
T28767	10637-10642	Protein	denotes	STAT4
T28766	10631-10636	Protein	denotes	IL-12
T28765	10617-10622	Protein	denotes	STAT6
T28764	10612-10616	Protein	denotes	IL-4
T28763	10493-10498	Protein	denotes	SOCS3
T28762	10483-10488	Protein	denotes	SOCS1
T28761	10453-10458	Protein	denotes	SOCS1
T28759	10407-10411	Protein	denotes	IL-4
T28758	10369-10374	Protein	denotes	SOCS3
T28757	10336-10341	Protein	denotes	STAT4
T28756	10322-10327	Protein	denotes	IL-12
T28755	10291-10296	Protein	denotes	SOCS3
T28754	10281-10286	Protein	denotes	SOCS1
T28753	10168-10173	Protein	denotes	SOCS1
T28752	10124-10129	Protein	denotes	IFN-γ
T28751	10105-10110	Protein	denotes	IL-10
T28750	10080-10085	Protein	denotes	IFN-γ
T28749	10023-10026	Protein	denotes	CD4
T28748	10008-10013	Protein	denotes	IFN-γ
T28747	9984-9987	Protein	denotes	CD4
T28746	9930-9935	Protein	denotes	SOCS1
T28745	9896-9900	Protein	denotes	IL-6
T28744	9858-9863	Protein	denotes	STAT3
T28743	9807-9812	Protein	denotes	SOCS3
T28742	9775-9780	Protein	denotes	STAT3
T28741	9760-9765	Protein	denotes	IL-10
T28740	9747-9752	Protein	denotes	IL-10
T28739	9665-9668	Protein	denotes	CD4
T28738	9642-9647	Protein	denotes	SOCS1
T28737	9601-9606	Protein	denotes	IL-10
T28736	9565-9570	Protein	denotes	SOCS1
T28735	9521-9526	Protein	denotes	IL-10
T28734	9423-9428	Protein	denotes	SOCS3
T28733	9370-9374	Protein	denotes	IL-6
T28732	9334-9339	Protein	denotes	SOCS3
T28731	9287-9292	Protein	denotes	SOCS3
T28730	9258-9262	Protein	denotes	IL-6
T28729	9237-9242	Protein	denotes	STAT3
T28728	9184-9189	Protein	denotes	SOCS1
T28727	9158-9163	Protein	denotes	SOCS3
T28726	9121-9126	Protein	denotes	SOCS3
T28725	9081-9086	Protein	denotes	IL-10
T28724	9055-9059	Protein	denotes	IL-6
T28723	9022-9027	Protein	denotes	SOCS3
T28722	9002-9007	Protein	denotes	SOCS1
T28721	8993-8998	Protein	denotes	SOCS3
T28720	8889-8894	Protein	denotes	IL-10
T28719	8880-8884	Protein	denotes	IL-6
T28718	8830-8835	Protein	denotes	SOCS3
T28717	8820-8825	Protein	denotes	SOCS1
T28716	8808-8813	Protein	denotes	gp130
T28715	8694-8699	Protein	denotes	SOCS3
T28714	8629-8634	Protein	denotes	SOCS1
T28713	8615-8618	Protein	denotes	CD4
T28712	8587-8592	Protein	denotes	SOCS3
T28711	8560-8565	Protein	denotes	SOCS1
T28710	8491-8494	Protein	denotes	CD4
T28709	8344-8349	Protein	denotes	STAT3
T28708	8329-8334	Protein	denotes	gp130
T28707	8228-8231	Protein	denotes	CD4
T28706	8181-8186	Protein	denotes	gp130
T28705	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T28704	8038-8043	Protein	denotes	gp130
T28703	7961-7966	Protein	denotes	gp130
T28702	7865-7870	Protein	denotes	STAT3
T28701	7719-7724	Protein	denotes	STAT3
T28700	7681-7685	Protein	denotes	IL-6
T28699	7593-7598	Protein	denotes	STAT3
T28698	7553-7557	Protein	denotes	IL-6
T28697	7514-7519	Protein	denotes	STAT3
T28696	7445-7453	Protein	denotes	type III
T28695	7416-7440	Protein	denotes	Fc gamma receptor type I
T28694	7269-7274	Protein	denotes	STAT3
T28693	7251-7255	Protein	denotes	IL-6
T28692	7158-7163	Protein	denotes	STAT3
T28691	7087-7092	Protein	denotes	STAT3
T28690	6928-6933	Protein	denotes	IL-10
T28689	6874-6879	Protein	denotes	IL-10
T28688	6832-6837	Protein	denotes	SOCS1
T28687	6815-6820	Protein	denotes	IFN-γ
T28686	6794-6799	Protein	denotes	STAT3
T28685	6761-6766	Protein	denotes	IL-10
T28684	6650-6655	Protein	denotes	IL-10
T28683	6592-6595	Protein	denotes	CD4
T28682	6574-6579	Protein	denotes	IL-10
T28681	6564-6569	Protein	denotes	IFN-γ
T28680	6528-6532	Protein	denotes	IL-6
T28679	6487-6492	Protein	denotes	TNF-α
T28678	6477-6482	Protein	denotes	IL-1β
T28677	6431-6434	Protein	denotes	CD4
T28676	6411-6416	Protein	denotes	IFN-γ
T28675	6396-6401	Protein	denotes	IL-10
T28674	6178-6182	Protein	denotes	IL-6
T28673	6104-6109	Protein	denotes	IL-10
T28672	6088-6091	Protein	denotes	CD4
T28671	6020-6025	Protein	denotes	STAT3
T28670	6006-6011	Protein	denotes	IL-10
T28669	5938-5941	Protein	denotes	CD4
T28668	5926-5931	Protein	denotes	IL-10
T28667	5856-5859	Protein	denotes	CD4
T28653	5697-5702	Protein	denotes	STAT3
T28652	5657-5661	Protein	denotes	IL-6
T28651	5566-5569	Protein	denotes	CD4
T28650	5537-5542	Protein	denotes	IL-10
T28649	5498-5503	Protein	denotes	STAT3
T28648	5446-5450	Protein	denotes	IL-6
T28647	5399-5402	Protein	denotes	CD4
T28646	5368-5373	Protein	denotes	IL-10
T28645	5272-5277	Protein	denotes	STAT3
T28644	5253-5257	Protein	denotes	IL-6
T28643	5055-5059	Protein	denotes	IL-6
T28642	5024-5029	Protein	denotes	IL-10
T28641	4975-4987	Protein	denotes	oncostatin M
T28640	4943-4969	Protein	denotes	leukemia inhibitory factor
T28639	4936-4941	Protein	denotes	IL-11
T28638	4930-4934	Protein	denotes	IL-6
T28637	4841-4846	Protein	denotes	STAT3
T28636	4810-4813	Protein	denotes	CD4
T28635	4705-4710	Protein	denotes	STAT3
T28634	4687-4692	Protein	denotes	STAT3
T28633	4672-4677	Protein	denotes	IL-10
T28632	4490-4495	Protein	denotes	IL-10
T28631	4448-4455	Protein	denotes	IL-10R1
T28630	4417-4422	Protein	denotes	STAT3
T28629	4401-4406	Protein	denotes	IL-10
T28628	4362-4367	Protein	denotes	IL-10
T28627	4346-4349	Protein	denotes	CD4
T28626	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T28625	4234-4238	Protein	denotes	IL-1
T28624	4227-4232	Protein	denotes	TNF-α
T28623	4159-4166	Protein	denotes	IL-10R1
T28892	10930-10935	Positive_regulation	denotes	lower
T28891	10901-10907	Positive_regulation	denotes	Higher
T28890	10942-10952	Gene_expression	denotes	expression
T28889	10914-10924	Gene_expression	denotes	expression
T28888	10824-10834	Gene_expression	denotes	expression
T28887	10768-10775	Gene_expression	denotes	express
T28886	10328-10335	Positive_regulation	denotes	induced
T28885	10459-10468	Positive_regulation	denotes	induction
T28884	10375-10384	Positive_regulation	denotes	induction
T28883	10342-10352	Positive_regulation	denotes	activation
T28882	10266-10270	Positive_regulation	denotes	high
T28881	10258-10265	Gene_expression	denotes	express
T28880	10157-10164	Positive_regulation	denotes	inducer
T28879	10057-10064	Gene_expression	denotes	produce
T28878	10000-10007	Gene_expression	denotes	produce
T28877	9953-9963	Positive_regulation	denotes	associated
T28876	9936-9945	Positive_regulation	denotes	induction
T28875	9797-9806	Negative_regulation	denotes	defective
T28851	8350-8360	Positive_regulation	denotes	activation
T28850	8264-8273	Positive_regulation	denotes	activated
T28849	8022-8029	Binding	denotes	binding
T28848	7631-7639	Positive_regulation	denotes	involved
T28847	7686-7696	Gene_expression	denotes	production
T28846	7599-7609	Positive_regulation	denotes	activation
T28845	7535-7542	Positive_regulation	denotes	induced
T28844	7504-7513	Positive_regulation	denotes	activated
T28843	7398-7408	Gene_expression	denotes	expression
T28842	7275-7285	Positive_regulation	denotes	activating
T28841	7182-7191	Gene_expression	denotes	expressed
T28840	7093-7103	Positive_regulation	denotes	activation
T28839	6951-6960	Regulation	denotes	modulated
T28622	4109-4114	Protein	denotes	IL-10
T28621	3889-3894	Protein	denotes	IFN-γ
T28620	3855-3859	Protein	denotes	Jak1
T28619	3841-3846	Protein	denotes	IL-10
T28618	3818-3825	Protein	denotes	IL-10R1
T28617	3707-3712	Protein	denotes	IL-10
T28616	3625-3630	Protein	denotes	STAT3
T28615	3610-3615	Protein	denotes	IL-10
T28614	3509-3513	Protein	denotes	Jak1
T28613	3490-3494	Protein	denotes	IL-1
T28612	3480-3485	Protein	denotes	TNF-α
T28611	3558-3562	Protein	denotes	IL-6
T28610	3548-3553	Protein	denotes	IL-10
T28609	3514-3519	Protein	denotes	STAT3
T28608	3177-3182	Protein	denotes	IL-10
T28607	2968-2972	Protein	denotes	IL-2
T28606	2958-2963	Protein	denotes	IFN-γ
T28605	2921-2925	Protein	denotes	CD28
T28604	2901-2906	Protein	denotes	IL-10
T28603	2869-2872	Protein	denotes	CD4
T28602	2754-2758	Protein	denotes	CD28
T28601	2664-2669	Protein	denotes	IL-10
T28600	2595-2599	Protein	denotes	CD86
T28599	2586-2590	Protein	denotes	CD80
T28598	2286-2289	Protein	denotes	CD4
T28597	2257-2262	Protein	denotes	IL-10
T28596	2240-2245	Protein	denotes	SOCS1
T28595	2214-2219	Protein	denotes	STAT3
T28594	2166-2171	Protein	denotes	STAT3
T28593	2150-2155	Protein	denotes	IL-10
T28592	2040-2045	Protein	denotes	IL-10
T28591	1982-1985	Protein	denotes	CD4
T28590	1939-1942	Protein	denotes	CD4
T28589	1895-1900	Protein	denotes	SOCS3
T28588	1861-1866	Protein	denotes	SOCS1
T28587	1823-1826	Protein	denotes	CD4
T28586	1802-1807	Protein	denotes	IFN-γ
T28585	1782-1787	Protein	denotes	IL-10
T28584	1751-1755	Protein	denotes	IL-6
T28583	1723-1726	Protein	denotes	CD4
T28582	1691-1696	Protein	denotes	STAT1
T28581	1677-1682	Protein	denotes	STAT3
T28580	1647-1651	Protein	denotes	IL-6
T28579	1634-1639	Protein	denotes	IL-10
T28578	1579-1584	Protein	denotes	STAT3
T28577	1559-1562	Protein	denotes	CD4
T28576	1523-1526	Protein	denotes	CD4
T28575	1497-1502	Protein	denotes	STAT3
T28574	1455-1460	Protein	denotes	IL-10
T28573	1437-1442	Protein	denotes	STAT3
T28572	1401-1408	Protein	denotes	IL-10R1
T28571	1368-1371	Protein	denotes	CD4
T28570	1337-1341	Protein	denotes	CD28
T28569	1317-1322	Protein	denotes	IFN-γ
T28568	1273-1278	Protein	denotes	IL-10
T28567	1211-1214	Protein	denotes	CD4
T28566	1046-1050	Protein	denotes	CD28
T28565	995-1000	Protein	denotes	IL-10
T28564	852-857	Protein	denotes	IL-10
T28563	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T28562	661-665	Protein	denotes	CD28
T28561	493-497	Protein	denotes	CD86
T28560	484-488	Protein	denotes	CD80
T28559	465-469	Protein	denotes	CD28
T28558	414-418	Protein	denotes	CD28
T28557	333-336	Protein	denotes	CD4
T28556	101-104	Protein	denotes	CD4
T28555	11-14	Protein	denotes	CD4
T28654	5747-5750	Protein	denotes	CD4
T28871	9864-9874	Positive_regulation	denotes	activation
T28870	9813-9823	Gene_expression	denotes	expression
T28869	9781-9791	Positive_regulation	denotes	activation
T28666	5838-5843	Protein	denotes	IL-10
T28665	5773-5778	Protein	denotes	IL-10
T28760	10420-10425	Protein	denotes	STAT6
T28874	9766-9774	Positive_regulation	denotes	mediated
T28873	9632-9641	Positive_regulation	denotes	Increased
T28872	9878-9886	Positive_regulation	denotes	response
T28868	9695-9705	Positive_regulation	denotes	associated
T28867	9648-9658	Gene_expression	denotes	expression
T28866	9293-9302	Negative_regulation	denotes	deficient
T28865	9213-9222	Positive_regulation	denotes	sustained
T28864	9246-9254	Positive_regulation	denotes	response
T28863	9223-9233	Positive_regulation	denotes	activation
T28862	9190-9200	Negative_regulation	denotes	deficiency
T28861	9164-9174	Negative_regulation	denotes	deficiency
T28860	9127-9136	Negative_regulation	denotes	deficient
T28859	8985-8992	Negative_regulation	denotes	lacking
T28858	8840-8847	Positive_regulation	denotes	induced
T28857	8730-8737	Binding	denotes	binding
T28856	8674-8681	Binding	denotes	binding
T28855	8571-8576	Positive_regulation	denotes	lower
T28854	8533-8542	Transcription	denotes	expressed
T28853	8335-8343	Positive_regulation	denotes	mediated
T28852	8291-8309	Positive_regulation	denotes	activation-induced
R15368	T28575	T28779	themeOf	STAT3,phosphorylation
R15370	T28578	T28780	themeOf	STAT3,phosphorylation
R15371	T28579	T28781	causeOf	IL-10,inducible
R15372	T28580	T28786	causeOf	IL-6,induces
R15375	T28581	T28784	themeOf	STAT3,phosphorylation
R15377	T28584	T28789	causeOf	IL-6,induces
R15378	T28586	T28785	themeOf	IFN-γ,production
R15379	T28588	T28790	themeOf	SOCS1,higher
R15380	T28589	T28791	themeOf	SOCS3,transcripts
R15383	T28594	T28793	themeOf	STAT3,activation
R15385	T28595	T28794	themeOf	STAT3,phosphorylation
R15386	T28596	T28795	themeOf	SOCS1,induction
R15387	T28597	T28799	causeOf	IL-10,mediated
R15389	T28598	T28797	themeOf	CD4,production
R15390	T28599	T28800	themeOf	CD80,express
R15393	T28602	T28801	themeOf	CD28,phosphorylation
R15395	T28604	T28803	themeOf	IL-10,defective
R15397	T28605	T28806	causeOf	CD28,costimulated
R15399	T28606	T28804	themeOf	IFN-γ,production
R15402	T28608	T28807	themeOf	IL-10,produced
R15404	T28665	T28828	themeOf	IL-10,secretion
R15405	T28615	T28809	causeOf	IL-10,mediated
R15406	T28668	T28829	themeOf	IL-10,producing
R15407	T28616	T28808	themeOf	STAT3,activation
R15408	T28618	T28810	themeOf	IL-10R1,expression
R15409	T28673	T28830	themeOf	IL-10,augmented
R15410	T28675	T28833	causeOf	IL-10,mediated
R15411	T28630	T28811	themeOf	STAT3,activation
R15412	T28676	T28831	themeOf	IFN-γ,inhibition
R15413	T28631	T28812	themeOf	IL-10R1,expression
R15414	T28632	T28814	themeOf	IL-10,modulated
R15415	T28678	T28832	themeOf	IL-1β,pretreatment
R15416	T28633	T28819	causeOf	IL-10,mediated
R15417	T28634	T28816	themeOf	STAT3,activation
R15418	T28679	T28832	themeOf	TNF-α,pretreatment
R15419	T28635	T28815	themeOf	STAT3,association
R15420	T28635	T28817	themeOf	STAT3,phosphorylated
R15421	T28637	T28820	themeOf	STAT3,activated
R15422	T28681	T28834	themeOf	IFN-γ,produced
R15423	T28681	T28835	causeOf	IFN-γ,responsible
R15425	T28681	T28835	causeOf	IFN-γ,responsible
R15426	T28682	T28834	themeOf	IL-10,produced
R15427	T28645	T28821	themeOf	STAT3,activating
R15428	T28682	T28835	causeOf	IL-10,responsible
R15429	T28649	T28822	themeOf	STAT3,activation
R15430	T28650	T28823	themeOf	IL-10,inhibition
R15431	T28682	T28835	causeOf	IL-10,responsible
R15432	T28685	T28837	causeOf	IL-10,stimulate
R15433	T28653	T28827	themeOf	STAT3,induced
R15434	T28686	T28836	themeOf	STAT3,activation
R15435	T28690	T28838	themeOf	IL-10,effect
R15436	T28761	T28885	themeOf	SOCS1,induction
R15437	T28691	T28840	themeOf	STAT3,activation
R15438	T28692	T28841	themeOf	STAT3,expressed
R15439	T28768	T28887	themeOf	SOCS3,express
R15440	T28769	T28888	themeOf	SOCS3,expression
R15441	T28770	T28889	themeOf	SOCS1,expression
R15442	T28693	T28842	themeOf	IL-6,activating
R15443	T28771	T28890	themeOf	SOCS3,expression
R15444	T28694	T28842	causeOf	STAT3,activating
R15445	T28775	T28776	themeOf	phosphorylation,inhibits
R15446	T28695	T28843	themeOf	Fc gamma receptor type I,expression
R15447	T28778	T28782	themeOf	expression,high-level
R15448	T28696	T28843	themeOf	type III,expression
R15449	T28779	T28783	themeOf	phosphorylation,induced
R15450	T28780	T28781	themeOf	phosphorylation,inducible
R15451	T28697	T28844	themeOf	STAT3,activated
R15452	T28697	T28845	themeOf	STAT3,induced
R15453	T28784	T28786	themeOf	phosphorylation,induces
R15454	T28784	T28786	themeOf	phosphorylation,induces
R15455	T28698	T28845	causeOf	IL-6,induced
R15456	T28785	T28787	themeOf	production,inhibition
R15457	T28699	T28846	themeOf	STAT3,activation
R15458	T28787	T28788	themeOf	inhibition,resistance
R15459	T28788	T28789	themeOf	resistance,induces
R15460	T28700	T28847	themeOf	IL-6,production
R15461	T28791	T28792	themeOf	transcripts,lower
R15462	T28703	T28849	themeOf	gp130,binding
R15463	T28794	T28796	themeOf	phosphorylation,sustained
R15464	T28703	T28849	themeOf	gp130,binding
R15465	T28797	T28798	themeOf	production,inhibition
R15466	T28798	T28799	themeOf	inhibition,mediated
R15467	T28704	T28849	themeOf	gp130,binding
R15468	T28704	T28849	themeOf	gp130,binding
R15469	T28801	T28802	themeOf	phosphorylation,inhibiting
R15470	T28705	T28849	themeOf	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor,binding
R15471	T28804	T28805	themeOf	production,inhibition
R15472	T28804	T28806	themeOf	production,costimulated
R15473	T28804	T28805	themeOf	production,inhibition
R15474	T28804	T28806	themeOf	production,costimulated
R15475	T28705	T28849	themeOf	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor,binding
R15476	T28706	T28850	themeOf	gp130,activated
R15477	T28808	T28809	themeOf	activation,mediated
R15478	T28708	T28853	causeOf	gp130,mediated
R15479	T28809	T28808	themeOf	mediated,activation
R15480	T28812	T28813	themeOf	expression,associated
R15481	T28812	T28811	themeOf	expression,activation
R15482	T28709	T28851	themeOf	STAT3,activation
R15483	T28816	T28818	themeOf	activation,impaired
R15484	T28816	T28819	themeOf	activation,mediated
R15485	T28711	T28854	themeOf	SOCS1,expressed
R15486	T28712	T28855	themeOf	SOCS3,lower
R15487	T28822	T28824	themeOf	activation,induced
R15488	T28822	T28825	themeOf	activation,sustained
R15489	T28823	T28826	themeOf	inhibition,resistance
R15490	T28712	T28854	themeOf	SOCS3,expressed
R15491	T28826	T28824	themeOf	resistance,induced
R15492	T28714	T28856	themeOf	SOCS1,binding
R15493	T28716	T28857	themeOf	gp130,binding
R15494	T28828	T28827	themeOf	secretion,induced
R15495	T28717	T28858	themeOf	SOCS1,induced
R15496	T28831	T28833	themeOf	inhibition,mediated
R15497	T28718	T28858	themeOf	SOCS3,induced
R15498	T28834	T28835	themeOf	produced,responsible
R15499	T28834	T28835	themeOf	produced,responsible
R15500	T28834	T28835	themeOf	produced,responsible
R15501	T28834	T28835	themeOf	produced,responsible
R15502	T28720	T28858	causeOf	IL-10,induced
R15503	T28836	T28837	themeOf	activation,stimulate
R15504	T28838	T28839	themeOf	effect,modulated
R15505	T28720	T28858	causeOf	IL-10,induced
R15506	T28721	T28859	themeOf	SOCS3,lacking
R15507	T28722	T28859	themeOf	SOCS1,lacking
R15508	T28726	T28860	themeOf	SOCS3,deficient
R15509	T28846	T28848	causeOf	activation,involved
R15510	T28847	T28848	themeOf	production,involved
R15511	T28727	T28861	themeOf	SOCS3,deficiency
R15512	T28851	T28852	themeOf	activation,activation-induced
R15513	T28851	T28853	themeOf	activation,mediated
R15514	T28728	T28862	themeOf	SOCS1,deficiency
R15515	T28729	T28863	themeOf	STAT3,activation
R15516	T28730	T28864	themeOf	IL-6,response
R15517	T28731	T28866	themeOf	SOCS3,deficient
R15518	T28738	T28867	themeOf	SOCS1,expression
R15519	T28863	T28865	themeOf	activation,sustained
R15520	T28867	T28868	themeOf	expression,associated
R15521	T28867	T28873	themeOf	expression,Increased
R15522	T28741	T28874	causeOf	IL-10,mediated
R15523	T28869	T28874	themeOf	activation,mediated
R15524	T28870	T28875	themeOf	expression,defective
R15525	T28872	T28871	themeOf	response,activation
R15526	T28742	T28869	themeOf	STAT3,activation
R15527	T28743	T28870	themeOf	SOCS3,expression
R15528	T28876	T28877	themeOf	induction,associated
R15529	T28744	T28871	themeOf	STAT3,activation
R15530	T28878	T28877	themeOf	produce,associated
R15531	T28745	T28872	themeOf	IL-6,response
R15532	T28881	T28882	themeOf	express,high
R15533	T28881	T28882	themeOf	express,high
R15534	T28883	T28886	themeOf	activation,induced
R15535	T28746	T28876	themeOf	SOCS1,induction
R15536	T28886	T28883	themeOf	induced,activation
R15537	T28748	T28878	themeOf	IFN-γ,produce
R15538	T28889	T28891	themeOf	expression,Higher
R15539	T28890	T28892	themeOf	expression,lower
R15540	T28750	T28879	themeOf	IFN-γ,produce
R15541	T28753	T28880	themeOf	SOCS1,inducer
R15543	T28754	T28881	themeOf	SOCS1,express
R15544	T28754	T28882	themeOf	SOCS1,high
R15545	T28755	T28881	themeOf	SOCS3,express
R15547	T28755	T28882	themeOf	SOCS3,high
R15549	T28756	T28886	causeOf	IL-12,induced
R15553	T28757	T28883	themeOf	STAT4,activation
R15557	T28758	T28884	themeOf	SOCS3,induction
R15351	T28559	T28773	themeOf	CD28,expressed
R15355	T28562	T28774	themeOf	CD28,engagement
R15358	T28565	T28776	causeOf	IL-10,inhibits
R15359	T28566	T28775	themeOf	CD28,phosphorylation
R15361	T28569	T28777	themeOf	IFN-γ,produce
R15364	T28572	T28778	themeOf	IL-10R1,expression
R15366	T28574	T28783	causeOf	IL-10,induced
R15353	T28560	T28773	themeOf	CD80,expressed
R15354	T28561	T28773	themeOf	CD86,expressed
R15363	T28570	T28777	themeOf	CD28,produce
R15373	T28580	T28786	causeOf	IL-6,induces
R15376	T28582	T28784	themeOf	STAT1,phosphorylation
R15392	T28600	T28800	themeOf	CD86,express
R15398	T28605	T28806	causeOf	CD28,costimulated
R15400	T28607	T28804	themeOf	IL-2,production
R15424	T28642	T28820	themeOf	IL-10,activated

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue	Speculation
T30114	5498-5514	Positive_regulation	denotes	STAT3 activation
T30113	4841-4859	Positive_regulation	denotes	STAT3 is activated
T30112	1641-1735	Gene_expression	denotes	Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
T30111	1641-1735	Positive_regulation	denotes	Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
T30110	9930-9945	Gene_expression	denotes	SOCS1 induction
T30109	9930-9945	Positive_regulation	denotes	SOCS1 induction
T30108	2257-2317	Regulation	denotes	IL-10-mediated inhibition of CD4+ T-cell cytokine production
T30107	8329-8360	Positive_regulation	denotes	gp130-mediated STAT3 activation
T30106	3693-3722	Positive_regulation	denotes	This impaired IL-10 signaling
T30105	1579-1600	Phosphorylation	denotes	STAT3 phosphorylation
T30104	7593-7701	Positive_regulation	denotes	STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37]
T30103	5537-5553	Negative_regulation	denotes	IL-10 inhibition
T30102	9601-9630	Regulation	denotes	IL-10-mediated signaling [43]
T30101	7087-7103	Positive_regulation	denotes	STAT3 activation
T30100	8329-8360	Regulation	denotes	gp130-mediated STAT3 activation
T30099	1010-1059	Phosphorylation	denotes	the tyrosine phosphorylation of the CD28 molecule
T30098	3693-3722	Negative_regulation	denotes	This impaired IL-10 signaling
T30097	6637-6676	Positive_regulation	denotes	for impaired IL-10 signaling in the ST,
T30096	4448-4466	Gene_expression	denotes	IL-10R1 expression
T30095	6874-6894	Positive_regulation	denotes	IL-10 signaling [32]
T30094	6396-6443	Regulation	denotes	IL-10-mediated IFN-γ inhibition in CD4+ T cells
T30093	6794-6810	Positive_regulation	denotes	STAT3 activation
T30092	10407-10481	Negative_regulation	denotes	IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
T30091	10407-10481	Negative_regulation	denotes	IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
T30090	3166-3192	Gene_expression	denotes	Endogenous IL-10, produced
T30089	9642-9677	Gene_expression	denotes	SOCS1 expression in RA CD4+ T cells
T30088	10930-10952	Gene_expression	denotes	lower SOCS3 expression
T30087	7865-7902	Positive_regulation	denotes	STAT3 signaling in Th1-cell-dominated
T30086	2918-2972	Positive_regulation	denotes	of CD28-costimulated production of both IFN-γ and IL-2
T30085	2918-2972	Positive_regulation	denotes	of CD28-costimulated production of both IFN-γ and IL-2
T30084	6574-6604	Gene_expression	denotes	IL-10 produced by CD4+ T cells
T30083	6896-7033	Regulation	denotes	The T-cell-inhibitory effect of IL-10 may therefore be modulated complicatedly upon exposure to an inflammatory environment in RA joints,	true
T30082	2790-2851	Negative_regulation	denotes	This direct effect also may be limited in active RA patients,	true
T30081	10322-10352	Positive_regulation	denotes	IL-12-induced STAT4 activation
T30080	9997-10013	Gene_expression	denotes	to produce IFN-γ
T30079	10450-10481	Positive_regulation	denotes	by SOCS1 induction in Th1 cells
T30078	10450-10481	Gene_expression	denotes	by SOCS1 induction in Th1 cells
T30077	9760-9792	Positive_regulation	denotes	IL-10-mediated STAT3 activation,
T30076	4658-4703	Regulation	denotes	with impaired IL-10-mediated STAT3 activation
T30075	6815-6845	Gene_expression	denotes	IFN-γ can induce SOCS1 protein	true
T30074	6815-6845	Positive_regulation	denotes	IFN-γ can induce SOCS1 protein	true
T30073	10407-10435	Positive_regulation	denotes	IL-4-induced STAT6 signaling
T30072	8629-8688	Negative_regulation	denotes	SOCS1 prevents activation of JAK by directly binding to JAK
T30071	10814-10834	Gene_expression	denotes	the SOCS3 expression
T30070	10322-10398	Negative_regulation	denotes	IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,
T30069	10322-10398	Negative_regulation	denotes	IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,
T30068	3610-3641	Positive_regulation	denotes	IL-10-mediated STAT3 activation
T30067	2141-2245	Positive_regulation	denotes	impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1
T30066	1799-1818	Gene_expression	denotes	of IFN-γ production
T30065	9843-9874	Positive_regulation	denotes	for persistent STAT3 activation
T30064	9642-9715	Binding	denotes	SOCS1 expression in RA CD4+ T cells may therefore be associated with both
T30063	4663-4686	Negative_regulation	denotes	impaired IL-10-mediated
T30062	4142-4167	Localization	denotes	of intracellular IL-10R1
T30061	2141-2165	Negative_regulation	denotes	impaired IL-10-dependent
T30060	9055-9069	Positive_regulation	denotes	IL-6 signaling
T30059	2743-2788	Negative_regulation	denotes	inhibiting CD28 tyrosine phosphorylation [33]
T30058	8644-8661	Positive_regulation	denotes	activation of JAK
T30057	8694-8818	Binding	denotes	SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
T30056	7363-7453	Gene_expression	denotes	of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
T30055	7363-7453	Gene_expression	denotes	of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
T30054	3610-3641	Regulation	denotes	IL-10-mediated STAT3 activation
T30053	7151-7249	Gene_expression	denotes	Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36]
T30052	9081-9096	Positive_regulation	denotes	IL-10 signaling
T30051	8629-8688	Binding	denotes	SOCS1 prevents activation of JAK by directly binding to JAK
T30050	1424-1454	Positive_regulation	denotes	constitutive STAT3 activation,
T30049	6761-6810	Positive_regulation	denotes	IL-10 may persistently stimulate STAT3 activation	true
T30048	9760-9792	Regulation	denotes	IL-10-mediated STAT3 activation,
T30047	6637-6676	Negative_regulation	denotes	for impaired IL-10 signaling in the ST,
T30046	10901-10924	Gene_expression	denotes	Higher SOCS1 expression
T30045	2204-2235	Phosphorylation	denotes	sustained STAT3 phosphorylation
T30044	10366-10398	Gene_expression	denotes	by SOCS3 induction in Th2 cells,
T30043	10366-10398	Positive_regulation	denotes	by SOCS3 induction in Th2 cells,
T30042	4351-4466	Positive_regulation	denotes	T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression
T30041	414-441	Regulation	denotes	CD28-mediated costimulation
T30040	1455-1502	Phosphorylation	denotes	IL-10-induced tyrosine phosphorylation of STAT3
T30039	9797-9823	Gene_expression	denotes	defective SOCS3 expression
T30038	6396-6443	Negative_regulation	denotes	IL-10-mediated IFN-γ inhibition in CD4+ T cells
T30037	1337-1355	Positive_regulation	denotes	CD28 costimulation
T30036	7681-7701	Gene_expression	denotes	IL-6 production [37]
T30035	2141-2245	Regulation	denotes	impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1
T30034	8820-8958	Positive_regulation	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30033	8820-8958	Gene_expression	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30032	8820-8958	Positive_regulation	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30031	8820-8958	Gene_expression	denotes	SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30030	4658-4703	Positive_regulation	denotes	with impaired IL-10-mediated STAT3 activation
T30029	1691-1712	Phosphorylation	denotes	STAT1 phosphorylation
T30028	2918-2972	Gene_expression	denotes	of CD28-costimulated production of both IFN-γ and IL-2
T30027	2918-2972	Gene_expression	denotes	of CD28-costimulated production of both IFN-γ and IL-2
T30026	1782-1818	Negative_regulation	denotes	IL-10 inhibition of IFN-γ production
T30025	2257-2393	Regulation	denotes	IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting
T30024	3841-3870	Positive_regulation	denotes	IL-10-induced Jak1 activation
T30023	4386-4466	Regulation	denotes	with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression
T30022	2874-2972	Negative_regulation	denotes	T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
T30021	2874-2972	Negative_regulation	denotes	T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
T30020	9548-9630	Negative_regulation	denotes	On the contrary, SOCS1 was found to directly inhibit IL-10-mediated signaling [43]
T30019	6874-6879	Protein	denotes	IL-10
T30018	4899-4903	Protein	denotes	IL-6
T30017	769-850	Protein	denotes	its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23]
T30016	4490-4495	Protein	denotes	IL-10
T30015	6650-6655	Protein	denotes	IL-10
T30014	2364-2374	Entity	denotes	macrophage
T30013	8379-8387	Protein	denotes	cytokine
T30012	8154-8172	Entity	denotes	phenylalanine [39]
T30011	7767-7819	Entity	denotes	of growth factor-dependent synovial fibroblasts [38]
T30010	2974-3073	Protein	denotes	Numerous cytokines, both proinflammatory and anti-inflammatory, have been detected in the ST of RA,
T30009	10041-10050	Protein	denotes	active RA
T30008	6085-6100	Entity	denotes	of CD4+ T cells
T30007	1802-1807	Protein	denotes	IFN-γ
T30006	2615-2636	Entity	denotes	MHC class II antigens
T30005	1820-1822	Protein	denotes	RA
T30004	4687-4692	Protein	denotes	STAT3
T30003	1634-1639	Protein	denotes	IL-10
T30002	1520-1522	Protein	denotes	RA
T30001	769-850	Entity	denotes	its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23]
T30000	10008-10013	Protein	denotes	IFN-γ
T29999	2166-2171	Protein	denotes	STAT3
T29998	5365-5373	Protein	denotes	to IL-10
T29997	2518-2520	Protein	denotes	RA
T29996	9237-9242	Protein	denotes	STAT3
T29995	3418-3443	Protein	denotes	stimulus-regulated kinase
T29994	1208-1210	Protein	denotes	PB
T29993	9662-9677	Entity	denotes	RA CD4+ T cells
T29992	2901-2906	Protein	denotes	IL-10
T29991	4106-4114	Protein	denotes	of IL-10
T29990	5960-5977	Protein	denotes	from the ST of RA
T29989	9896-9900	Protein	denotes	IL-6
T29988	2037-2045	Protein	denotes	of IL-10
T29987	333-345	Entity	denotes	CD4+ T cells
T29986	1356-1380	Entity	denotes	than normal CD4+ T cells
T29985	1337-1341	Protein	denotes	CD28
T29984	1455-1468	Protein	denotes	IL-10-induced
T29983	6153-6169	Protein	denotes	the inflamed ST,
T29982	82-89	Protein	denotes	RA [22]
T29981	8587-8593	Protein	denotes	SOCS3,
T29980	484-488	Protein	denotes	CD80
T29979	1039-1059	Protein	denotes	of the CD28 molecule
T29978	7040-7054	Protein	denotes	many cytokines
T29977	3203-3214	Entity	denotes	macrophages
T29976	7593-7598	Protein	denotes	STAT3
T29975	8720-8726	Protein	denotes	of JAK
T29974	5926-5936	Protein	denotes	IL-10 [34]
T29973	9518-9526	Protein	denotes	of IL-10
T29972	1120-1127	Entity	denotes	T cells
T29971	5853-5878	Entity	denotes	RA CD4+ T cells in the ST
T29970	5938-5977	Entity	denotes	CD4+ T cells isolated from the ST of RA
T29969	5872-5878	Protein	denotes	the ST
T29968	6431-6443	Entity	denotes	CD4+ T cells
T29967	5253-5257	Protein	denotes	IL-6
T29966	575-611	Entity	denotes	presenting cells such as macrophages
T29965	1677-1712	Protein	denotes	STAT3 but not STAT1 phosphorylation
T29964	172-183	Entity	denotes	osteoclasts
T29963	2497-2503	Entity	denotes	T-cell
T29962	9293-9314	Entity	denotes	deficient macrophages
T29961	4142-4166	Protein	denotes	of intracellular IL-10R1
T29960	4663-4686	Protein	denotes	impaired IL-10-mediated
T29959	5498-5503	Protein	denotes	STAT3
T29958	8407-8430	Protein	denotes	by the JAK–STAT pathway
T29957	5657-5661	Protein	denotes	IL-6
T29956	2141-2165	Protein	denotes	impaired IL-10-dependent
T29955	10612-10622	Protein	denotes	IL-4–STAT6
T29954	2866-2868	Protein	denotes	PB
T29953	10612-10622	Protein	denotes	IL-4–STAT6
T29952	8820-8825	Protein	denotes	SOCS1
T29951	2874-2881	Entity	denotes	T cells
T29950	8125-8137	Entity	denotes	tyrosine 759
T29949	6925-6933	Protein	denotes	of IL-10
T29948	2361-2393	Entity	denotes	of macrophage antigen-presenting
T29947	2921-2938	Protein	denotes	CD28-costimulated
T29946	4340-4349	Protein	denotes	of RA CD4
T29945	1741-1755	Protein	denotes	exogenous IL-6
T29944	7681-7685	Protein	denotes	IL-6
T29943	2394-2398	Entity	denotes	cell
T29942	6306-6315	Protein	denotes	cytokines
T29941	2586-2590	Protein	denotes	CD80
T29940	7087-7092	Protein	denotes	STAT3
T29939	513-525	Protein	denotes	MHC class II
T29938	4828-4830	Protein	denotes	RA
T29937	6669-6675	Protein	denotes	the ST
T29936	1520-1535	Entity	denotes	RA CD4+ T cells
T29935	7995-7998	Protein	denotes	Src
T29934	9565-9570	Protein	denotes	SOCS1
T29933	8523-8532	Protein	denotes	active RA
T29932	2545-2551	Protein	denotes	the ST
T29931	3818-3825	Protein	denotes	IL-10R1
T29930	3448-3468	Protein	denotes	p38 kinase pathways,
T29929	4244-4297	Protein	denotes	granulocyte–macrophage colony-stimulating factor [15]
T29928	5747-5759	Entity	denotes	CD4+ T cells
T29927	2615-2627	Protein	denotes	MHC class II
T29926	8603-8627	Entity	denotes	with normal CD4+ T cells
T29925	10617-10622	Protein	denotes	STAT6
T29924	3668-3670	Protein	denotes	RA
T29923	513-534	Entity	denotes	MHC class II antigens
T29922	9530-9546	Entity	denotes	macrophages [41]
T29921	9287-9292	Protein	denotes	SOCS3
T29920	2968-2972	Protein	denotes	IL-2
T29919	1716-1735	Entity	denotes	normal CD4+ T cells
T29918	4943-4969	Protein	denotes	leukemia inhibitory factor
T29917	7581-7587	Protein	denotes	the ST
T29916	4930-4934	Protein	denotes	IL-6
T29915	2958-2963	Protein	denotes	IFN-γ
T29914	9807-9812	Protein	denotes	SOCS3
T29913	4202-4210	Protein	denotes	cytokine
T29912	8629-8634	Protein	denotes	SOCS1
T29911	7954-7981	Protein	denotes	of the gp130F759/F759 mice,
T29910	6020-6025	Protein	denotes	STAT3
T29909	6832-6845	Protein	denotes	SOCS1 protein
T29908	8745-8748	Protein	denotes	Src
T29907	10706-10753	Entity	denotes	PB T cells from patients with allergic diseases
T29906	9022-9027	Protein	denotes	SOCS3
T29905	567-574	Entity	denotes	antigen
T29904	10936-10941	Protein	denotes	SOCS3
T29903	1014-1022	Entity	denotes	tyrosine
T29813	2530-2551	Entity	denotes	macrophages in the ST
T29812	10791-10809	Protein	denotes	SOCS3 transcripts,
T29811	4873-4886	Protein	denotes	of cytokines,
T29810	5055-5059	Protein	denotes	IL-6
T29809	3625-3630	Protein	denotes	STAT3
T29808	461-477	Entity	denotes	the CD28 ligands
T29807	9601-9615	Protein	denotes	IL-10-mediated
T29806	4841-4846	Protein	denotes	STAT3
T29805	8738-8818	Entity	denotes	to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
T29804	9106-9126	Protein	denotes	of conditional SOCS3
T29803	6006-6019	Protein	denotes	IL-10-induced
T29802	10791-10796	Protein	denotes	SOCS3
T29801	7151-7163	Protein	denotes	Active STAT3
T29800	1208-1253	Entity	denotes	PB CD4+ T cells from patients with active RA,
T29799	1861-1866	Protein	denotes	SOCS1
T29798	2595-2599	Protein	denotes	CD86
T29797	9642-9647	Protein	denotes	SOCS1
T29796	7719-7724	Protein	denotes	STAT3
T29795	3976-3982	Protein	denotes	the Ig
T29794	8694-8699	Protein	denotes	SOCS3
T29793	5828-5843	Protein	denotes	exogenous IL-10
T29792	6794-6799	Protein	denotes	STAT3
T29791	9343-9412	Entity	denotes	a crucial inhibitor of the IL-6-induced transcriptional response [42]
T29790	5024-5033	Protein	denotes	IL-10 [4]
T29789	6712-6734	Protein	denotes	both cytokines [34,35]
T29788	10956-10963	Protein	denotes	PB CD4+
T29787	383-399	Protein	denotes	antigen receptor
T29786	2754-2758	Protein	denotes	CD28
T29785	124-135	Entity	denotes	macrophages
T29784	6574-6604	Protein	denotes	IL-10 produced by CD4+ T cells
T29711	223-232	Entity	denotes	molecules
T29710	8008-8019	Protein	denotes	phosphatase
T29709	2257-2271	Protein	denotes	IL-10-mediated
T29708	8980-9007	Protein	denotes	mice lacking SOCS3 or SOCS1
T29707	10165-10173	Protein	denotes	of SOCS1
T29706	493-497	Protein	denotes	CD86
T29705	1579-1584	Protein	denotes	STAT3
T29704	852-857	Protein	denotes	IL-10
T29703	3805-3836	Entity	denotes	cell surface IL-10R1 expression
T29702	10291-10301	Protein	denotes	SOCS3 mRNA
T29701	8830-8835	Protein	denotes	SOCS3
T29700	7023-7025	Protein	denotes	RA
T29699	2240-2245	Protein	denotes	SOCS1
T29698	9081-9086	Protein	denotes	IL-10
T29697	3276-3278	Protein	denotes	ST
T29696	4343-4345	Protein	denotes	RA
T29695	1329-1332	Protein	denotes	CD3
T29694	7514-7519	Protein	denotes	STAT3
T29693	6564-6569	Protein	denotes	IFN-γ
T29692	7553-7558	Protein	denotes	IL-6,
T29691	1437-1442	Protein	denotes	STAT3
T29690	4914-4988	Protein	denotes	cytokines (e.g. IL-6, IL-11, leukemia inhibitory factor, and oncostatin M)
T29689	6761-6766	Protein	denotes	IL-10
T29688	2068-2084	Protein	denotes	the inflamed ST,
T29687	9127-9141	Protein	denotes	deficient mice
T29902	8233-8239	Entity	denotes	T-cell
T29901	10637-10642	Protein	denotes	STAT4
T29900	10023-10050	Entity	denotes	CD4+ T cells from active RA
T29899	4211-4297	Protein	denotes	stimuli such as TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15]
T29898	10420-10425	Protein	denotes	STAT6
T29897	8790-8807	Protein	denotes	receptors such as
T29896	1691-1696	Protein	denotes	STAT1
T29895	6832-6837	Protein	denotes	SOCS1
T29894	3514-3519	Protein	denotes	STAT3
T29893	3668-3691	Entity	denotes	RA synovial macrophages
T29892	3219-3226	Entity	denotes	T cells
T29891	7251-7255	Protein	denotes	IL-6
T29890	3400-3494	Entity	denotes	the extracellular stimulus-regulated kinase and p38 kinase pathways, induced by TNF-α and IL-1
T29889	10336-10341	Protein	denotes	STAT4
T29888	3993-4006	Protein	denotes	receptor [14]
T29887	11-23	Entity	denotes	CD4+ T cells
T29755	2839-2841	Protein	denotes	RA
T29686	3558-3562	Protein	denotes	IL-6
T29685	1401-1408	Protein	denotes	IL-10R1
T29684	4936-4941	Protein	denotes	IL-11
T29683	616-639	Entity	denotes	dendritic cells [18-20]
T29682	964-975	Entity	denotes	macrophages
T29681	4362-4367	Protein	denotes	IL-10
T29680	7865-7870	Protein	denotes	STAT3
T29679	3707-3712	Protein	denotes	IL-10
T29678	9981-9996	Entity	denotes	of CD4+ T cells
T29677	10964-10971	Entity	denotes	T cells
T29676	8451-8455	Protein	denotes	SOCS
T29675	3889-3953	Entity	denotes	IFN-γ-primed macrophages by a protein kinase C-dependent pathway
T29674	3480-3485	Protein	denotes	TNF-α
T29673	1820-1835	Entity	denotes	RA CD4+ T cells
T29672	1641-1651	Protein	denotes	Serum IL-6
T29671	8682-8688	Protein	denotes	to JAK
T29670	5446-5450	Protein	denotes	IL-6
T29669	9002-9007	Protein	denotes	SOCS1
T29668	2664-2669	Protein	denotes	IL-10
T29667	3610-3624	Protein	denotes	IL-10-mediated
T29749	207-222	Entity	denotes	of cell surface
T29748	8491-8532	Entity	denotes	CD4+ T cells from patients with active RA
T29747	2575-2584	Protein	denotes	cytokines
T29746	3548-3553	Protein	denotes	IL-10
T29745	6104-6109	Protein	denotes	IL-10
T29744	980-989	Entity	denotes	Th1 cells
T29743	8045-8122	Protein	denotes	the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T29742	1657-1659	Protein	denotes	RA
T29741	2283-2317	Entity	denotes	of CD4+ T-cell cytokine production
T29740	10369-10374	Protein	denotes	SOCS3
T29739	658-665	Protein	denotes	of CD28
T29738	10281-10286	Protein	denotes	SOCS1
T29737	9329-9339	Protein	denotes	that SOCS3
T29736	10453-10458	Protein	denotes	SOCS1
T29735	7366-7374	Entity	denotes	monocyte
T29734	1895-1900	Protein	denotes	SOCS3
T29733	6815-6820	Protein	denotes	IFN-γ
T29732	1317-1322	Protein	denotes	IFN-γ
T29731	4351-4358	Entity	denotes	T cells
T29730	4705-4710	Protein	denotes	STAT3
T29729	3070-3072	Protein	denotes	RA
T29728	6411-6416	Protein	denotes	IFN-γ
T29727	10248-10257	Entity	denotes	Th2 cells
T29726	1564-1571	Entity	denotes	T cells
T29725	8889-8894	Protein	denotes	IL-10
T29724	8196-8210	Protein	denotes	mice, T cells,
T29723	7195-7227	Entity	denotes	synovial fluid mononuclear cells
T29722	9662-9664	Protein	denotes	RA
T29721	4417-4422	Protein	denotes	STAT3
T29720	2754-2788	Entity	denotes	CD28 tyrosine phosphorylation [33]
T29719	10706-10708	Protein	denotes	PB
T29718	3448-3451	Protein	denotes	p38
T29717	10291-10296	Protein	denotes	SOCS3
T29716	1273-1279	Protein	denotes	IL-10,
T29715	10908-10913	Protein	denotes	SOCS1
T29714	10105-10111	Protein	denotes	IL-10,
T29713	684-699	Entity	denotes	T-cell-mediated
T29712	10631-10642	Protein	denotes	IL-12–STAT4
T29783	446-478	Protein	denotes	the ST lesion, the CD28 ligands,
T29782	10322-10335	Protein	denotes	IL-12-induced
T29781	6528-6549	Protein	denotes	IL-6 (data not shown)
T29780	137-157	Entity	denotes	synovial fibroblasts
T29779	8993-8998	Protein	denotes	SOCS3
T29778	2716-2722	Entity	denotes	T-cell
T29777	9775-9780	Protein	denotes	STAT3
T29776	8418-8422	Protein	denotes	STAT
T29775	6396-6410	Protein	denotes	IL-10-mediated
T29774	5773-5778	Protein	denotes	IL-10
T29773	5853-5855	Protein	denotes	RA
T29772	1982-1994	Entity	denotes	CD4+ T cells
T29771	7412-7440	Protein	denotes	the Fc gamma receptor type I
T29770	3766-3791	Entity	denotes	immune complexes in vivo,
T29769	1158-1170	Entity	denotes	T cells [24]
T29768	4800-4822	Entity	denotes	PB and ST CD4+ T cells
T29767	9158-9201	Protein	denotes	SOCS3 deficiency, but not SOCS1 deficiency,
T29766	4727-4735	Entity	denotes	tyrosine
T29765	8344-8349	Protein	denotes	STAT3
T29764	4800-4802	Protein	denotes	PB
T29763	10977-10979	Protein	denotes	RA
T29762	6487-6492	Protein	denotes	TNF-α
T29761	10493-10498	Protein	denotes	SOCS3
T29760	1469-1477	Entity	denotes	tyrosine
T29759	4042-4044	Protein	denotes	RA
T29758	5154-5164	Protein	denotes	active RA,
T29757	10631-10642	Protein	denotes	IL-12–STAT4
T29756	237-251	Protein	denotes	Th1 cytokines,
T29754	3490-3494	Protein	denotes	IL-1
T29753	10388-10397	Entity	denotes	Th2 cells
T29752	4505-4522	Entity	denotes	inflammatory cell
T29751	3855-3859	Protein	denotes	Jak1
T29750	5329-5331	Protein	denotes	RA
T29848	3060-3072	Protein	denotes	the ST of RA
T29847	5392-5411	Entity	denotes	normal CD4+ T cells
T29846	7770-7793	Protein	denotes	growth factor-dependent
T29845	9760-9774	Protein	denotes	IL-10-mediated
T29844	9747-9752	Protein	denotes	IL-10
T29843	10407-10419	Protein	denotes	IL-4-induced
T29842	2575-2610	Entity	denotes	cytokines, CD80 and CD86 molecules,
T29841	9423-9428	Protein	denotes	SOCS3
T29840	2866-2872	Protein	denotes	PB CD4
T29839	4448-4455	Protein	denotes	IL-10R1
T29838	8202-8209	Entity	denotes	T cells
T29837	7445-7453	Protein	denotes	type III
T29836	3276-3289	Entity	denotes	ST cells [12]
T29835	7259-7318	Protein	denotes	the major STAT3-activating factor present in synovial fluid
T29834	3166-3192	Protein	denotes	Endogenous IL-10, produced
T29833	9055-9059	Protein	denotes	IL-6
T29832	5038-5054	Protein	denotes	these cytokines,
T29831	9184-9201	Protein	denotes	SOCS1 deficiency,
T29830	10818-10823	Protein	denotes	SOCS3
T29829	3841-3854	Protein	denotes	IL-10-induced
T29828	8560-8565	Protein	denotes	SOCS1
T29827	5563-5578	Entity	denotes	RA CD4+ T cells
T29826	8444-8475	Protein	denotes	by the SOCS family proteins [7]
T29825	91-113	Entity	denotes	Activated CD4+ T cells
T29824	10472-10481	Entity	denotes	Th1 cells
T29823	586-599	Entity	denotes	cells such as
T29822	5563-5565	Protein	denotes	RA
T29821	10124-10129	Protein	denotes	IFN-γ
T29820	4807-4814	Protein	denotes	ST CD4+
T29819	1895-1912	Protein	denotes	SOCS3 transcripts
T29818	8880-8884	Protein	denotes	IL-6
T29817	9258-9262	Protein	denotes	IL-6
T29816	4021-4036	Entity	denotes	dendritic cells
T29815	4391-4416	Protein	denotes	defective IL-10-dependent
T29814	6178-6182	Protein	denotes	IL-6
T29860	414-427	Protein	denotes	CD28-mediated
T29859	7233-7235	Protein	denotes	RA
T29858	1552-1562	Protein	denotes	normal CD4
T29857	9930-9935	Protein	denotes	SOCS1
T29856	6861-6894	Entity	denotes	inhibitor of IL-10 signaling [32]
T29855	5975-5977	Protein	denotes	RA
T29854	383-390	Entity	denotes	antigen
T29853	1243-1252	Protein	denotes	active RA
T29852	2699-2715	Entity	denotes	antigen-specific
T29851	1782-1787	Protein	denotes	IL-10
T29850	834-836	Protein	denotes	RA
T29849	3919-3945	Protein	denotes	protein kinase C-dependent
T29886	8848-8895	Protein	denotes	by various cytokines, including IL-6 and IL-10,
T29885	3574-3590	Entity	denotes	macrophages [13]
T29884	8655-8661	Protein	denotes	of JAK
T29883	159-166	Entity	denotes	B cells
T29882	4234-4239	Protein	denotes	IL-1,
T29881	8329-8343	Protein	denotes	gp130-mediated
T29880	4639-4641	Protein	denotes	RA
T29879	6477-6482	Protein	denotes	IL-1β
T29878	10483-10488	Protein	denotes	SOCS1
T29877	5537-5542	Protein	denotes	IL-10
T29876	8790-8818	Protein	denotes	receptors such as gp130 [40]
T29875	995-1000	Protein	denotes	IL-10
T29874	8035-8123	Protein	denotes	of gp130 (the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor)
T29873	1494-1502	Protein	denotes	of STAT3
T29872	2214-2219	Protein	denotes	STAT3
T29871	1932-1951	Entity	denotes	normal CD4+ T cells
T29870	465-469	Protein	denotes	CD28
T29869	9858-9863	Protein	denotes	STAT3
T29868	6589-6604	Entity	denotes	by CD4+ T cells
T29867	3505-3562	Protein	denotes	the Jak1–STAT3 signaling pathway shared by IL-10 and IL-6
T29866	5692-5702	Protein	denotes	that STAT3
T29865	4975-4987	Protein	denotes	oncostatin M
T29864	4145-4158	Entity	denotes	intracellular
T29863	10080-10085	Protein	denotes	IFN-γ
T29862	7147-7149	Protein	denotes	RA
T29861	6685-6691	Entity	denotes	T-cell
R15936	T29667	T30054	causeOf	IL-10-mediated,IL-10-mediated STAT3 activation
R15940	T29671	T30051	themeOf	to JAK,SOCS1 prevents activation of JAK by directly binding to JAK
R15942	T29672	T30111	causeOf	Serum IL-6,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R15945	T29679	T30106	causeOf	IL-10,This impaired IL-10 signaling
R15946	T29680	T30087	causeOf	STAT3,STAT3 signaling in Th1-cell-dominated
R15949	T29689	T30049	causeOf	IL-10,IL-10 may persistently stimulate STAT3 activation
R15950	T29691	T30050	themeOf	STAT3,"constitutive STAT3 activation,"
R15952	T29698	T30052	causeOf	IL-10,IL-10 signaling
R15955	T29701	T30031	themeOf	SOCS3,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R15956	T29701	T30034	themeOf	SOCS3,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R15959	T29705	T30105	themeOf	STAT3,STAT3 phosphorylation
R15961	T29709	T30108	causeOf	IL-10-mediated,IL-10-mediated inhibition of CD4+ T-cell cytokine production
R15964	T29715	T30046	themeOf	SOCS1,Higher SOCS1 expression
R15965	T29721	T30042	themeOf	STAT3,"T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R15967	T29751	T30024	themeOf	Jak1,IL-10-induced Jak1 activation
R15968	T29728	T30038	themeOf	IFN-γ,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R15969	T29733	T30074	causeOf	IFN-γ,IFN-γ can induce SOCS1 protein
R15970	T29760	T29873	partOf	tyrosine,of STAT3
R15971	T29736	T30078	themeOf	SOCS1,by SOCS1 induction in Th1 cells
R15972	T29736	T30079	themeOf	SOCS1,by SOCS1 induction in Th1 cells
R15973	T29740	T30043	themeOf	SOCS3,"by SOCS3 induction in Th2 cells,"
R15974	T29740	T30044	themeOf	SOCS3,"by SOCS3 induction in Th2 cells,"
R15975	T29760	T30040	siteOf	tyrosine,IL-10-induced tyrosine phosphorylation of STAT3
R15976	T29765	T30107	themeOf	STAT3,gp130-mediated STAT3 activation
R15977	T29815	T30023	causeOf	defective IL-10-dependent,"with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R15978	T29771	T30056	themeOf	the Fc gamma receptor type I,of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
R15979	T29775	T30094	causeOf	IL-10-mediated,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R15980	T29777	T30077	themeOf	STAT3,"IL-10-mediated STAT3 activation,"
R15981	T29830	T30071	themeOf	SOCS3,the SOCS3 expression
R15982	T29833	T30060	causeOf	IL-6,IL-6 signaling
R15983	T29834	T30090	themeOf	"Endogenous IL-10, produced","Endogenous IL-10, produced"
R15984	T29784	T30084	themeOf	IL-10 produced by CD4+ T cells,IL-10 produced by CD4+ T cells
R15985	T29837	T30055	themeOf	type III,of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
R15986	T29839	T30096	themeOf	IL-10R1,IL-10R1 expression
R15987	T29845	T30048	causeOf	IL-10-mediated,"IL-10-mediated STAT3 activation,"
R15988	T29792	T30093	themeOf	STAT3,STAT3 activation
R15989	T29851	T30026	causeOf	IL-10,IL-10 inhibition of IFN-γ production
R15990	T29794	T30057	themeOf	SOCS3,SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
R15991	T29797	T30089	themeOf	SOCS1,SOCS1 expression in RA CD4+ T cells
R15992	T29857	T30109	themeOf	SOCS1,SOCS1 induction
R15993	T29857	T30110	themeOf	SOCS1,SOCS1 induction
R15994	T29860	T30041	causeOf	CD28-mediated,CD28-mediated costimulation
R15995	T29801	T30053	themeOf	Active STAT3,Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36]
R15996	T29864	T30062	locationOf	intracellular,of intracellular IL-10R1
R15997	T29806	T30113	themeOf	STAT3,STAT3 is activated
R15998	T29869	T30065	themeOf	STAT3,for persistent STAT3 activation
R15999	T29872	T30045	themeOf	STAT3,sustained STAT3 phosphorylation
R16000	T29873	T30040	themeOf	of STAT3,IL-10-induced tyrosine phosphorylation of STAT3
R16001	T29807	T30102	causeOf	IL-10-mediated,IL-10-mediated signaling [43]
R16002	T29809	T30068	themeOf	STAT3,IL-10-mediated STAT3 activation
R16003	T29877	T30103	themeOf	IL-10,IL-10 inhibition
R16004	T29889	T30081	themeOf	STAT4,IL-12-induced STAT4 activation
R16005	T29881	T30100	causeOf	gp130-mediated,gp130-mediated STAT3 activation
R16006	T29884	T30058	themeOf	of JAK,activation of JAK
R16007	T29886	T30032	causeOf	"by various cytokines, including IL-6 and IL-10,","SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16008	T29886	T30034	causeOf	"by various cytokines, including IL-6 and IL-10,","SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16009	T29896	T30029	themeOf	STAT1,STAT1 phosphorylation
R16010	T29898	T30073	causeOf	STAT6,IL-4-induced STAT6 signaling
R16011	T29992	T30021	causeOf	IL-10,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16012	T29992	T30022	causeOf	IL-10,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16013	T29903	T29979	partOf	tyrosine,of the CD28 molecule
R16014	T29999	T30067	themeOf	STAT3,"impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16015	T30000	T30080	themeOf	IFN-γ,to produce IFN-γ
R16016	T29903	T30099	siteOf	tyrosine,the tyrosine phosphorylation of the CD28 molecule
R16017	T30004	T30030	themeOf	STAT3,with impaired IL-10-mediated STAT3 activation
R16018	T29904	T30088	themeOf	SOCS3,lower SOCS3 expression
R16019	T30007	T30066	themeOf	IFN-γ,of IFN-γ production
R16020	T29909	T30074	themeOf	SOCS1 protein,IFN-γ can induce SOCS1 protein
R16021	T29909	T30075	themeOf	SOCS1 protein,IFN-γ can induce SOCS1 protein
R16022	T30015	T30097	causeOf	IL-10,"for impaired IL-10 signaling in the ST,"
R16023	T29912	T30051	themeOf	SOCS1,SOCS1 prevents activation of JAK by directly binding to JAK
R16024	T30019	T30095	causeOf	IL-10,IL-10 signaling [32]
R16025	T29914	T30039	themeOf	SOCS3,defective SOCS3 expression
R16026	T29915	T30028	themeOf	IFN-γ,of CD28-costimulated production of both IFN-γ and IL-2
R16027	T30027	T30021	themeOf	of CD28-costimulated production of both IFN-γ and IL-2,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16028	T30027	T30086	themeOf	of CD28-costimulated production of both IFN-γ and IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16029	T29920	T30027	themeOf	IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16030	T30028	T30022	themeOf	of CD28-costimulated production of both IFN-γ and IL-2,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16031	T30028	T30085	themeOf	of CD28-costimulated production of both IFN-γ and IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16032	T30030	T30076	themeOf	with impaired IL-10-mediated STAT3 activation,with impaired IL-10-mediated STAT3 activation
R16033	T29940	T30101	themeOf	STAT3,STAT3 activation
R16034	T30038	T30094	themeOf	IL-10-mediated IFN-γ inhibition in CD4+ T cells,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R16035	T30042	T30023	themeOf	"T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression","with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R16036	T30043	T30069	causeOf	"by SOCS3 induction in Th2 cells,","IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16037	T30044	T30070	causeOf	"by SOCS3 induction in Th2 cells,","IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16038	T30058	T30072	themeOf	activation of JAK,SOCS1 prevents activation of JAK by directly binding to JAK
R16039	T29944	T30036	themeOf	IL-6,IL-6 production [37]
R16040	T30066	T30026	themeOf	of IFN-γ production,IL-10 inhibition of IFN-γ production
R16041	T30067	T30035	themeOf	"impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1","impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16042	T29947	T30085	causeOf	CD28-costimulated,of CD28-costimulated production of both IFN-γ and IL-2
R16043	T30068	T30054	themeOf	IL-10-mediated STAT3 activation,IL-10-mediated STAT3 activation
R16044	T29947	T30086	causeOf	CD28-costimulated,of CD28-costimulated production of both IFN-γ and IL-2
R16045	T30073	T30091	themeOf	IL-4-induced STAT6 signaling,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16046	T30073	T30092	themeOf	IL-4-induced STAT6 signaling,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16047	T29952	T30032	themeOf	SOCS1,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16048	T30077	T30048	themeOf	"IL-10-mediated STAT3 activation,","IL-10-mediated STAT3 activation,"
R16049	T30078	T30092	causeOf	by SOCS1 induction in Th1 cells,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16050	T30079	T30091	causeOf	by SOCS1 induction in Th1 cells,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16051	T29952	T30033	themeOf	SOCS1,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16052	T29956	T30035	causeOf	impaired IL-10-dependent,"impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16053	T30081	T30069	themeOf	IL-12-induced STAT4 activation,"IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16054	T30081	T30070	themeOf	IL-12-induced STAT4 activation,"IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16055	T29956	T30061	themeOf	impaired IL-10-dependent,impaired IL-10-dependent
R16056	T29959	T30114	themeOf	STAT3,STAT3 activation
R16057	T29960	T30063	themeOf	impaired IL-10-mediated,impaired IL-10-mediated
R16058	T30093	T30049	themeOf	STAT3 activation,IL-10 may persistently stimulate STAT3 activation
R16059	T29960	T30076	causeOf	impaired IL-10-mediated,with impaired IL-10-mediated STAT3 activation
R16060	T29961	T30062	themeOf	of intracellular IL-10R1,of intracellular IL-10R1
R16061	T30097	T30047	themeOf	"for impaired IL-10 signaling in the ST,","for impaired IL-10 signaling in the ST,"
R16062	T29965	T30111	themeOf	STAT3 but not STAT1 phosphorylation,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R16063	T29965	T30112	themeOf	STAT3 but not STAT1 phosphorylation,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R16064	T29976	T30104	themeOf	STAT3,STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37]
R16065	T30106	T30098	themeOf	This impaired IL-10 signaling,This impaired IL-10 signaling
R16066	T30107	T30100	themeOf	gp130-mediated STAT3 activation,gp130-mediated STAT3 activation
R16067	T29979	T30099	themeOf	of the CD28 molecule,the tyrosine phosphorylation of the CD28 molecule
R16068	T29985	T30037	themeOf	CD28,CD28 costimulation

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T29338	11148-11149	.	denotes	.
T29337	11147-11148	NNP	denotes	]
T29336	11142-11147	CD	denotes	46-49
T29335	11141-11142	NNP	denotes	[
T29334	11128-11140	VBN	denotes	demonstrated
T29333	11123-11127	VBN	denotes	been
T29332	11112-11122	RB	denotes	previously
T29331	11108-11111	VBZ	denotes	has
T29330	11105-11107	RB	denotes	as
T29329	11103-11104	,	denotes	,
T29328	11094-11103	NN	denotes	phenotype
T29327	11090-11093	JJ	denotes	Th1
T29326	11088-11089	DT	denotes	a
T29325	11080-11087	IN	denotes	towards
T29324	11075-11079	NN	denotes	bias
T29323	11066-11074	JJ	denotes	systemic
T29322	11060-11065	PRP$	denotes	their
T29321	11055-11059	IN	denotes	with
T29320	11044-11054	JJ	denotes	consistent
T29319	11035-11043	RB	denotes	probably
T29318	11025-11034	RB	denotes	therefore
T29317	11022-11024	VBZ	denotes	is
T29316	11020-11021	,	denotes	,
T29315	11012-11020	NNS	denotes	controls
T29314	11004-11011	JJ	denotes	healthy
T29313	10999-11003	IN	denotes	with
T29312	10990-10998	VBN	denotes	compared
T29311	10988-10989	,	denotes	,
T29310	10980-10988	NNS	denotes	patients
T29309	10977-10979	NNP	denotes	RA
T29308	10972-10976	IN	denotes	from
T29307	10966-10971	NNS	denotes	cells
T29306	10964-10965	NNP	denotes	T
T29305	10962-10963	VBD	denotes	+
T29304	10959-10962	NNP	denotes	CD4
T29303	10956-10958	NNP	denotes	PB
T29302	10953-10955	IN	denotes	in
T29301	10942-10952	NN	denotes	expression
T29300	10936-10941	JJ	denotes	SOCS3
T29299	10930-10935	JJR	denotes	lower
T29298	10925-10929	IN	denotes	with
T29297	10914-10924	NN	denotes	expression
T29296	10908-10913	CD	denotes	SOCS1
T29295	10901-10907	JJR	denotes	Higher
T29294	10899-10900	.	denotes	.
T29293	10898-10899	NNP	denotes	]
T29292	10896-10898	CD	denotes	45
T29291	10895-10896	NNP	denotes	[
T29290	10885-10894	NN	denotes	pathology
T29289	10877-10884	NN	denotes	disease
T29288	10873-10876	CC	denotes	and
T29287	10866-10872	NNS	denotes	levels
T29286	10862-10865	NNP	denotes	IgE
T29285	10856-10861	NN	denotes	serum
T29284	10851-10855	IN	denotes	with
T29283	10846-10850	RB	denotes	well
T29282	10835-10845	VBZ	denotes	correlates
T29281	10824-10834	NN	denotes	expression
T29280	10818-10823	NNP	denotes	SOCS3
T29279	10814-10817	DT	denotes	the
T29278	10810-10813	CC	denotes	and
T29277	10808-10809	,	denotes	,
T29276	10797-10808	NNS	denotes	transcripts
T29275	10791-10796	CD	denotes	SOCS3
T29274	10788-10790	IN	denotes	of
T29273	10781-10787	NNS	denotes	levels
T29272	10776-10780	JJ	denotes	high
T29271	10768-10775	VBP	denotes	express
T29270	10754-10767	RB	denotes	significantly
T29269	10745-10753	NNS	denotes	diseases
T29268	10736-10744	JJ	denotes	allergic
T29267	10731-10735	IN	denotes	with
T29266	10722-10730	NNS	denotes	patients
T29265	10717-10721	IN	denotes	from
T29264	10711-10716	NNS	denotes	cells
T29263	10709-10710	NNP	denotes	T
T29262	10706-10708	NNP	denotes	PB
T29232	10513-10522	JJ	denotes	important
T29231	10508-10512	VB	denotes	have
T29230	10503-10507	RB	denotes	thus
T29229	10499-10502	MD	denotes	may
T29228	10493-10498	CD	denotes	SOCS3
T29227	10489-10492	CC	denotes	and
T29226	10483-10488	CD	denotes	SOCS1
T29225	10481-10482	.	denotes	.
T29224	10476-10481	NNS	denotes	cells
T29223	10472-10475	JJ	denotes	Th1
T29222	10469-10471	IN	denotes	in
T29221	10459-10468	NN	denotes	induction
T29220	10453-10458	CD	denotes	SOCS1
T29219	10450-10452	IN	denotes	by
T29218	10439-10449	VBN	denotes	diminished
T29217	10436-10438	VBZ	denotes	is
T29216	10426-10435	VBG	denotes	signaling
T29215	10420-10425	NNP	denotes	STAT6
T29214	10407-10419	JJ	denotes	IL-4-induced
T29213	10399-10406	IN	denotes	whereas
T29212	10397-10398	,	denotes	,
T29211	10392-10397	NNS	denotes	cells
T29210	10388-10391	JJ	denotes	Th2
T29209	10385-10387	IN	denotes	in
T29208	10375-10384	NN	denotes	induction
T29207	10369-10374	CD	denotes	SOCS3
T29206	10366-10368	IN	denotes	by
T29205	10356-10365	VBN	denotes	inhibited
T29204	10353-10355	VBZ	denotes	is
T29203	10342-10352	NN	denotes	activation
T29202	10336-10341	CD	denotes	STAT4
T29201	10322-10335	JJ	denotes	IL-12-induced
T29200	10320-10321	.	denotes	.
T29199	10319-10320	NNP	denotes	]
T29198	10317-10319	CD	denotes	44
T29197	10316-10317	NNP	denotes	[
T29196	10303-10315	RB	denotes	respectively
T29195	10301-10302	,	denotes	,
T29194	10297-10301	NNP	denotes	mRNA
T29193	10291-10296	CD	denotes	SOCS3
T29192	10287-10290	CC	denotes	and
T29191	10281-10286	CD	denotes	SOCS1
T28545	10015-10022	IN	denotes	because
T28544	10013-10014	,	denotes	,
T28543	10008-10013	NNP	denotes	IFN-γ
T28542	10000-10007	VB	denotes	produce
T28541	9997-9999	TO	denotes	to
T28540	9991-9996	NNS	denotes	cells
T28539	9989-9990	NNP	denotes	T
T28538	9987-9988	CD	denotes	+
T28537	9984-9987	CD	denotes	CD4
T28536	9981-9983	IN	denotes	of
T28535	9973-9980	NN	denotes	ability
T28534	9969-9972	DT	denotes	the
T28533	9964-9968	IN	denotes	with
T28532	9953-9963	VBN	denotes	associated
T28531	9950-9952	VB	denotes	be
T28530	9946-9949	MD	denotes	may
T28529	9936-9945	NN	denotes	induction
T28528	9930-9935	CD	denotes	SOCS1
T28527	9925-9929	IN	denotes	that
T28526	9913-9924	NN	denotes	possibility
T28525	9911-9912	DT	denotes	a
T28524	9908-9910	VBZ	denotes	is
T28523	9902-9907	EX	denotes	There
T28522	9900-9901	.	denotes	.
T28521	9896-9900	NNP	denotes	IL-6
T28520	9890-9895	VB	denotes	serum
T28519	9887-9889	TO	denotes	to
T28518	9878-9886	NN	denotes	response
T28517	9875-9877	IN	denotes	in
T28516	9864-9874	NN	denotes	activation
T28515	9858-9863	CD	denotes	STAT3
T28514	9847-9857	JJ	denotes	persistent
T28513	9843-9846	IN	denotes	for
T28512	9831-9842	JJ	denotes	responsible
T28511	9828-9830	VB	denotes	be
T28510	9824-9827	MD	denotes	may
T28509	9813-9823	NN	denotes	expression
T28508	9807-9812	CD	denotes	SOCS3
T28507	9797-9806	JJ	denotes	defective
T28506	9793-9796	CC	denotes	and
T28505	9791-9792	,	denotes	,
T28504	9781-9791	NN	denotes	activation
T28503	9775-9780	CD	denotes	STAT3
T28502	9760-9774	JJ	denotes	IL-10-mediated
T28501	9757-9759	TO	denotes	to
T28500	9753-9756	CC	denotes	and
T28499	9747-9752	NNP	denotes	IL-10
T28498	9744-9746	TO	denotes	to
T28497	9729-9743	NN	denotes	responsiveness
T28496	9720-9728	VBN	denotes	impaired
T28495	9716-9719	DT	denotes	the
T28494	9711-9715	DT	denotes	both
T28493	9706-9710	IN	denotes	with
T28492	9695-9705	VBN	denotes	associated
T28491	9692-9694	VB	denotes	be
T28490	9682-9691	RB	denotes	therefore
T28489	9678-9681	MD	denotes	may
T28488	9672-9677	NNS	denotes	cells
T28487	9670-9671	NNP	denotes	T
T28486	9668-9669	VBD	denotes	+
T28485	9665-9668	NNP	denotes	CD4
T28484	9662-9664	NNP	denotes	RA
T28483	9659-9661	IN	denotes	in
T28482	9648-9658	NN	denotes	expression
T28481	9642-9647	CD	denotes	SOCS1
T28480	9632-9641	VBN	denotes	Increased
T28479	9630-9631	.	denotes	.
T28478	9629-9630	NNP	denotes	]
T28477	9627-9629	CD	denotes	43
T28476	9626-9627	NNP	denotes	[
T28475	9616-9625	VBG	denotes	signaling
T28474	9601-9615	JJ	denotes	IL-10-mediated
T28473	9593-9600	VB	denotes	inhibit
T28472	9584-9592	RB	denotes	directly
T28471	9581-9583	TO	denotes	to
T28470	9575-9580	VBN	denotes	found
T28469	9571-9574	VBD	denotes	was
T28468	9565-9570	NNP	denotes	SOCS1
T28467	9563-9564	,	denotes	,
T28466	9555-9563	NN	denotes	contrary
T28465	9551-9554	DT	denotes	the
T28464	9548-9550	IN	denotes	On
T28463	9546-9547	.	denotes	.
T28462	9545-9546	NNP	denotes	]
T28461	9543-9545	CD	denotes	41
T28460	9542-9543	NNP	denotes	[
T28459	9530-9541	NNS	denotes	macrophages
T28458	9527-9529	IN	denotes	in
T28457	9521-9526	NN	denotes	IL-10
T28456	9518-9520	IN	denotes	of
T28455	9511-9517	NN	denotes	action
T28454	9494-9510	JJ	denotes	immunoregulatory
T28453	9490-9493	DT	denotes	the
T28452	9486-9489	CC	denotes	and
T28451	9475-9485	NN	denotes	inhibition
T28450	9466-9474	NN	denotes	feedback
T28449	9457-9465	JJ	denotes	negative
T28448	9453-9456	DT	denotes	the
T28447	9448-9452	DT	denotes	both
T28446	9444-9447	IN	denotes	for
T28445	9432-9443	JJ	denotes	dispensable
T28444	9429-9431	VBZ	denotes	is
T28443	9423-9428	NNP	denotes	SOCS3
T28442	9421-9422	,	denotes	,
T28441	9414-9421	RB	denotes	However
T28440	9412-9413	.	denotes	.
T28439	9411-9412	NNP	denotes	]
T28438	9409-9411	CD	denotes	42
T28437	9408-9409	NNP	denotes	[
T28436	9399-9407	NN	denotes	response
T28435	9383-9398	JJ	denotes	transcriptional
T28434	9370-9382	JJ	denotes	IL-6-induced
T28433	9366-9369	DT	denotes	the
T28432	9363-9365	IN	denotes	of
T28431	9353-9362	NN	denotes	inhibitor
T28430	9345-9352	JJ	denotes	crucial
T28429	9343-9344	DT	denotes	a
T28428	9340-9342	VBZ	denotes	is
T28427	9334-9339	CD	denotes	SOCS3
T28426	9329-9333	IN	denotes	that
T28425	9319-9328	VBN	denotes	indicated
T28424	9315-9318	VBZ	denotes	has
T28423	9303-9314	NNS	denotes	macrophages
T28422	9287-9302	JJ	denotes	SOCS3-deficient
T28421	9284-9286	IN	denotes	of
T28420	9275-9283	NN	denotes	analysis
T28419	9271-9274	DT	denotes	The
T28418	9269-9270	.	denotes	.
T28417	9268-9269	NNP	denotes	]
T28416	9264-9268	CD	denotes	8,41
T28415	9263-9264	NNP	denotes	[
T28414	9258-9262	NNP	denotes	IL-6
T28413	9255-9257	TO	denotes	to
T28412	9246-9254	NN	denotes	response
T28411	9243-9245	IN	denotes	in
T28410	9237-9242	CD	denotes	STAT3
T28409	9234-9236	IN	denotes	of
T28408	9223-9233	NN	denotes	activation
T28407	9213-9222	VBN	denotes	sustained
T28406	9210-9212	IN	denotes	in
T28405	9202-9209	NNS	denotes	results
T28404	9200-9201	,	denotes	,
T28403	9190-9200	NN	denotes	deficiency
T28402	9184-9189	CD	denotes	SOCS1
T28401	9180-9183	RB	denotes	not
T28400	9176-9179	CC	denotes	but
T28399	9174-9175	,	denotes	,
T28398	9164-9174	NN	denotes	deficiency
T28397	9158-9163	CD	denotes	SOCS3
T28396	9153-9157	IN	denotes	that
T28395	9147-9152	VBN	denotes	shown
T28394	9142-9146	VBP	denotes	have
T28393	9137-9141	NNS	denotes	mice
T28392	9121-9136	JJ	denotes	SOCS3-deficient
T28391	9109-9120	JJ	denotes	conditional
T28390	9106-9108	IN	denotes	of
T28389	9098-9105	NNS	denotes	Studies
T28388	9096-9097	.	denotes	.
T28387	9087-9096	VBG	denotes	signaling
T28386	9081-9086	NN	denotes	IL-10
T28385	9078-9080	IN	denotes	of
T28384	9074-9077	RB	denotes	not
T28383	9070-9073	CC	denotes	but
T28382	9060-9069	VBG	denotes	signaling
T28381	9055-9059	NNP	denotes	IL-6
T28380	9052-9054	IN	denotes	of
T28379	9042-9051	NN	denotes	regulator
T28378	9033-9041	JJ	denotes	negative
T28377	9031-9032	DT	denotes	a
T28376	9028-9030	VBZ	denotes	is
T28375	9022-9027	CD	denotes	SOCS3
T28374	9017-9021	IN	denotes	that
T28373	9008-9016	VBD	denotes	revealed
T28372	9002-9007	CD	denotes	SOCS1
T28371	8999-9001	CC	denotes	or
T28370	8993-8998	CD	denotes	SOCS3
T28369	8985-8992	VBG	denotes	lacking
T28368	8980-8984	NNS	denotes	mice
T28367	8975-8979	IN	denotes	with
T28366	8967-8974	NNS	denotes	studies
T28365	8960-8966	JJ	denotes	Recent
T28364	8958-8959	.	denotes	.
T28363	8957-8958	NNP	denotes	]
T28362	8956-8957	CD	denotes	7
T28361	8955-8956	NN	denotes	[
T28360	8944-8954	NN	denotes	inhibition
T28359	8934-8943	NN	denotes	crosstalk
T28358	8930-8933	CC	denotes	and
T28357	8921-8929	NN	denotes	feedback
T28356	8912-8920	JJ	denotes	negative
T28355	8909-8911	IN	denotes	of
T28354	8899-8908	NNS	denotes	mediators
T28353	8896-8898	IN	denotes	as
T28352	8894-8895	,	denotes	,
T28351	8889-8894	NNP	denotes	IL-10
T28350	8885-8888	CC	denotes	and
T28349	8880-8884	NNP	denotes	IL-6
T28348	8870-8879	VBG	denotes	including
T28347	8868-8869	,	denotes	,
T28346	8859-8868	NNS	denotes	cytokines
T28345	8851-8858	JJ	denotes	various
T28344	8848-8850	IN	denotes	by
T28343	8840-8847	VBN	denotes	induced
T28342	8836-8839	VBP	denotes	are
T28341	8830-8835	CD	denotes	SOCS3
T28340	8826-8829	CC	denotes	and
T28339	8820-8825	CD	denotes	SOCS1
T28338	8818-8819	.	denotes	.
T28337	8817-8818	NNP	denotes	]
T28336	8815-8817	CD	denotes	40
T28335	8814-8815	NNP	denotes	[
T28334	8808-8813	CD	denotes	gp130
T28333	8805-8807	IN	denotes	as
T28332	8800-8804	JJ	denotes	such
T28331	8790-8799	NNS	denotes	receptors
T28330	8787-8789	IN	denotes	of
T28270	8474-8475	NNP	denotes	]
T28269	8473-8474	CD	denotes	7
T28268	8472-8473	VBP	denotes	[
T28267	8463-8471	NNS	denotes	proteins
T28266	8456-8462	NN	denotes	family
T28265	8451-8455	NNP	denotes	SOCS
T28264	8447-8450	DT	denotes	the
T28263	8444-8446	IN	denotes	by
T28262	8434-8443	VBN	denotes	regulated
T28261	8431-8433	VBZ	denotes	is
T28260	8423-8430	NN	denotes	pathway
T28259	8418-8422	NNP	denotes	STAT
T28258	8414-8417	NNP	denotes	JAK
T28257	8410-8413	DT	denotes	the
T28256	8407-8409	IN	denotes	by
T28255	8396-8406	VBN	denotes	transduced
T28254	8388-8395	NNS	denotes	signals
T28253	8379-8387	NN	denotes	cytokine
T28252	8376-8378	IN	denotes	of
T28251	8366-8375	NN	denotes	longevity
T28250	8362-8365	DT	denotes	The
T28249	8360-8361	.	denotes	.
T28248	8350-8360	NN	denotes	activation
T28247	8344-8349	CD	denotes	STAT3
T28246	8329-8343	JJ	denotes	gp130-mediated
T28245	8321-8328	IN	denotes	through
T28244	8315-8320	NN	denotes	death
T28243	8310-8314	NN	denotes	cell
T28242	8291-8309	JJ	denotes	activation-induced
T28241	8288-8290	TO	denotes	to
T28240	8278-8287	JJ	denotes	resistant
T28239	8274-8277	CC	denotes	and
T28238	8264-8273	VBN	denotes	activated
T28237	8252-8263	RB	denotes	chronically
T28236	8248-8251	VBP	denotes	are
T28235	8246-8247	,	denotes	,
T28234	8240-8246	NN	denotes	subset
T28233	8233-8239	NNP	denotes	T-cell
T28232	8231-8232	NNP	denotes	+
T28231	8228-8231	NNP	denotes	CD4
T28230	8224-8227	DT	denotes	the
T28229	8211-8223	RB	denotes	particularly
T28228	8209-8210	,	denotes	,
T28227	8204-8209	NNS	denotes	cells
T28226	8202-8203	NNP	denotes	T
T28225	8200-8201	,	denotes	,
T28224	8196-8200	NNS	denotes	mice
T28223	8181-8195	NNP	denotes	gp130F759/F759
T28222	8177-8180	DT	denotes	the
T28221	8174-8176	IN	denotes	In
T28220	8172-8173	.	denotes	.
T28219	8171-8172	NNP	denotes	]
T28218	8169-8171	CD	denotes	39
T28217	8168-8169	NNP	denotes	[
T28216	8154-8167	VB	denotes	phenylalanine
T28215	8151-8153	TO	denotes	to
T28214	8143-8150	VBN	denotes	mutated
T28213	8139-8142	VBD	denotes	was
T28212	8137-8138	,	denotes	,
T28211	8134-8137	CD	denotes	759
T28210	8125-8133	JJ	denotes	tyrosine
T28209	8123-8124	,	denotes	,
T28208	8122-8123	-RRB-	denotes	)
T28207	8114-8122	NN	denotes	receptor
T28206	8105-8113	NN	denotes	cytokine
T28205	8098-8104	NN	denotes	family
T28204	8093-8097	NNP	denotes	IL-6
T28203	8089-8092	DT	denotes	the
T28202	8086-8088	IN	denotes	of
T28201	8078-8085	NN	denotes	subunit
T28200	8076-8077	NN	denotes	β
T28199	8063-8075	NN	denotes	glycoprotein
T28198	8049-8062	NN	denotes	transmembrane
T28197	8045-8048	DT	denotes	the
T28196	8044-8045	-LRB-	denotes	(
T28195	8038-8043	CD	denotes	gp130
T28194	8035-8037	IN	denotes	of
T28193	8030-8034	NN	denotes	site
T28192	8022-8029	JJ	denotes	binding
T28191	8008-8021	JJ	denotes	phosphatase-2
T28190	7999-8007	NN	denotes	homology
T28189	7995-7998	NNP	denotes	Src
T28188	7991-7994	DT	denotes	the
T28187	7985-7990	WDT	denotes	which
T28186	7982-7984	IN	denotes	in
T28185	7980-7981	,	denotes	,
T28184	7976-7980	NNS	denotes	mice
T28183	7961-7975	NNP	denotes	gp130F759/F759
T28182	7957-7960	DT	denotes	the
T28181	7954-7956	IN	denotes	of
T28180	7946-7953	NNS	denotes	studies
T28179	7943-7945	IN	denotes	by
T28178	7933-7942	VBN	denotes	suggested
T28177	7928-7932	VBN	denotes	been
T28140	7698-7700	CD	denotes	37
T28139	7697-7698	NNP	denotes	[
T28138	7686-7696	NN	denotes	production
T28137	7681-7685	NN	denotes	IL-6
T28136	7677-7680	CC	denotes	and
T28135	7663-7676	NN	denotes	proliferation
T28134	7652-7662	NN	denotes	fibroblast
T28133	7643-7651	JJ	denotes	synovial
T28132	7640-7642	IN	denotes	in
T28131	7631-7639	VBN	denotes	involved
T28130	7628-7630	VB	denotes	be
T28129	7625-7627	TO	denotes	to
T28128	7619-7624	VBN	denotes	shown
T28127	7614-7618	VBN	denotes	been
T28126	7610-7613	VBZ	denotes	has
T28125	7599-7609	NN	denotes	activation
T28124	7593-7598	NNP	denotes	STAT3
T28123	7589-7592	CC	denotes	and
T28122	7587-7588	,	denotes	,
T28121	7585-7587	NNP	denotes	ST
T28120	7581-7584	DT	denotes	the
T28119	7578-7580	IN	denotes	in
T28118	7569-7577	VBN	denotes	detected
T28117	7564-7568	VBN	denotes	been
T28116	7559-7563	VBP	denotes	have
T28115	7557-7558	,	denotes	,
T28114	7553-7557	NNP	denotes	IL-6
T28113	7550-7552	IN	denotes	by
T28112	7543-7549	RB	denotes	mainly
T28111	7535-7542	JJ	denotes	induced
T28110	7532-7534	VB	denotes	be
T28109	7529-7531	TO	denotes	to
T28108	7521-7528	VBD	denotes	thought
T28107	7519-7520	,	denotes	,
T28106	7514-7519	NNP	denotes	STAT3
T28105	7504-7513	VBN	denotes	activated
T28104	7501-7503	IN	denotes	of
T28103	7494-7500	NNS	denotes	levels
T28102	7489-7493	JJ	denotes	high
T28101	7487-7488	,	denotes	,
T28100	7479-7487	RB	denotes	recently
T28099	7474-7478	RBR	denotes	More
T28098	7472-7473	.	denotes	.
T28097	7471-7472	NNP	denotes	]
T28096	7469-7471	CD	denotes	31
T28095	7468-7469	NNP	denotes	[
T28094	7461-7467	NNP	denotes	HLA-DR
T28093	7458-7460	IN	denotes	of
T28092	7454-7457	CC	denotes	and
T28091	7450-7453	NNP	denotes	III
T28090	7445-7449	NN	denotes	type
T28089	7441-7444	CC	denotes	and
T28088	7439-7440	PRP	denotes	I
T28087	7434-7438	NN	denotes	type
T28554	10057-10064	VB	denotes	produce
T28553	10051-10056	MD	denotes	could
T28552	10048-10050	NNP	denotes	RA
T28551	10041-10047	JJ	denotes	active
T28550	10036-10040	IN	denotes	from
T28549	10030-10035	NNS	denotes	cells
T28548	10028-10029	NNP	denotes	T
T28547	10026-10027	NNP	denotes	+
T28546	10023-10026	NNP	denotes	CD4
T28086	7425-7433	NN	denotes	receptor
T28085	7419-7424	NN	denotes	gamma
T28084	7416-7418	NNP	denotes	Fc
T28083	7412-7415	DT	denotes	the
T28082	7409-7411	IN	denotes	of
T28081	7398-7408	NN	denotes	expression
T28080	7393-7397	NN	denotes	gene
T28079	7390-7392	IN	denotes	as
T28078	7385-7389	JJ	denotes	such
T28077	7375-7384	NNS	denotes	functions
T28076	7366-7374	NN	denotes	monocyte
T28075	7363-7365	IN	denotes	of
T28074	7352-7362	NN	denotes	activation
T28073	7348-7351	DT	denotes	the
T28072	7345-7347	IN	denotes	in
T28071	7340-7344	NN	denotes	role
T28070	7332-7339	JJ	denotes	crucial
T28069	7330-7331	DT	denotes	a
T28068	7326-7329	VBZ	denotes	has
T28067	7320-7325	WDT	denotes	which
T28066	7318-7319	,	denotes	,
T28065	7313-7318	NN	denotes	fluid
T28064	7304-7312	JJ	denotes	synovial
T28063	7301-7303	IN	denotes	in
T28062	7293-7300	NN	denotes	present
T28061	7286-7292	NN	denotes	factor
T28060	7269-7285	JJ	denotes	STAT3-activating
T28059	7263-7268	JJ	denotes	major
T28058	7259-7262	DT	denotes	the
T28057	7256-7258	VBZ	denotes	is
T28056	7251-7255	NN	denotes	IL-6
T28055	7249-7250	.	denotes	.
T27815	5879-5882	VBP	denotes	are
T27814	5876-5878	NNP	denotes	ST
T27813	5872-5875	DT	denotes	the
T27812	5869-5871	IN	denotes	in
T27811	5863-5868	NNS	denotes	cells
T27810	5861-5862	NNP	denotes	T
T27809	5859-5860	VBD	denotes	+
T27808	5856-5859	NNP	denotes	CD4
T27807	5853-5855	NNP	denotes	RA
T27806	5845-5852	IN	denotes	because
T27805	5843-5844	,	denotes	,
T27804	5838-5843	NN	denotes	IL-10
T27803	5828-5837	JJ	denotes	exogenous
T27802	5825-5827	TO	denotes	to
T27801	5813-5824	NN	denotes	sensitivity
T27800	5810-5812	IN	denotes	of
T27799	5805-5809	NN	denotes	loss
T27798	5801-5804	DT	denotes	the
T27797	5798-5800	TO	denotes	to
T27796	5790-5797	VBG	denotes	leading
T27795	5788-5789	,	denotes	,
T27794	5779-5788	NN	denotes	secretion
T27793	5773-5778	NN	denotes	IL-10
T27792	5769-5772	JJ	denotes	own
T27791	5763-5768	PRP$	denotes	their
T27790	5760-5762	IN	denotes	by
T27789	5754-5759	NNS	denotes	cells
T27788	5752-5753	NNP	denotes	T
T27787	5750-5751	CD	denotes	+
T27786	5747-5750	CD	denotes	CD4
T27785	5744-5746	IN	denotes	in
T27784	5736-5743	VBN	denotes	induced
T27783	5721-5735	RB	denotes	constitutively
T27782	5718-5720	VB	denotes	be
T27781	5712-5717	MD	denotes	could
T27780	5703-5711	NN	denotes	activity
T27779	5697-5702	JJ	denotes	STAT3
T27778	5692-5696	IN	denotes	that
T27777	5683-5691	JJ	denotes	possible
T27776	5678-5682	RB	denotes	also
T27775	5675-5677	VBZ	denotes	is
T27774	5672-5674	PRP	denotes	it
T27773	5670-5671	,	denotes	,
T27772	5663-5670	RB	denotes	However
T27771	5661-5662	.	denotes	.
T27770	5657-5661	NN	denotes	IL-6
T27769	5651-5656	NN	denotes	serum
T27768	5648-5650	IN	denotes	of
T27767	5633-5647	NNS	denotes	concentrations
T27766	5628-5632	JJ	denotes	high
T27765	5625-5627	TO	denotes	to
T27764	5620-5624	NN	denotes	vivo
T27763	5617-5619	IN	denotes	in
T27762	5608-5616	NN	denotes	exposure
T27761	5600-5607	JJ	denotes	chronic
T27760	5594-5599	IN	denotes	after
T27759	5586-5593	VBN	denotes	induced
T27758	5583-5585	VB	denotes	be
T27757	5579-5582	MD	denotes	may
T27756	5573-5578	NNS	denotes	cells
T27755	5571-5572	NNP	denotes	T
T27754	5569-5570	VBD	denotes	+
T27753	5566-5569	NNP	denotes	CD4
T27752	5563-5565	NNP	denotes	RA
T27751	5560-5562	IN	denotes	in
T27750	5554-5559	VBD	denotes	found
T27749	5543-5553	NN	denotes	inhibition
T27748	5537-5542	NNP	denotes	IL-10
T27747	5534-5536	TO	denotes	to
T27746	5523-5533	NN	denotes	resistance
T27745	5519-5522	DT	denotes	the
T27744	5515-5518	CC	denotes	and
T27743	5504-5514	NN	denotes	activation
T27742	5498-5503	CD	denotes	STAT3
T27741	5488-5497	VBN	denotes	sustained
T27740	5484-5487	DT	denotes	the
T27739	5479-5483	DT	denotes	both
T27738	5474-5478	IN	denotes	that
T27737	5466-5473	VBP	denotes	suggest
T27736	5458-5465	NNS	denotes	results
T27735	5452-5457	DT	denotes	These
T27734	5450-5451	.	denotes	.
T27733	5446-5450	NN	denotes	IL-6
T27732	5441-5445	IN	denotes	with
T27731	5430-5440	NN	denotes	incubation
T27730	5427-5429	IN	denotes	of
T27729	5421-5426	NNS	denotes	hours
T27728	5418-5420	CD	denotes	36
T27727	5412-5417	IN	denotes	after
T27655	5032-5033	NNP	denotes	]
T27654	5031-5032	CD	denotes	4
T27653	5030-5031	NNP	denotes	[
T27652	5024-5029	NNP	denotes	IL-10
T27651	5021-5023	TO	denotes	to
T27650	5012-5020	NN	denotes	addition
T27649	5009-5011	IN	denotes	in
T27648	5007-5008	,	denotes	,
T27647	5000-5007	NNS	denotes	factors
T27646	4993-4999	NN	denotes	growth
T27645	4989-4992	CC	denotes	and
T27644	4987-4988	-RRB-	denotes	)
T27643	4986-4987	NNP	denotes	M
T27642	4975-4985	NN	denotes	oncostatin
T27641	4971-4974	CC	denotes	and
T27640	4969-4970	,	denotes	,
T27639	4963-4969	NN	denotes	factor
T27638	4952-4962	JJ	denotes	inhibitory
T27637	4943-4951	NN	denotes	leukemia
T27636	4941-4942	,	denotes	,
T27635	4936-4941	NNP	denotes	IL-11
T27634	4934-4935	,	denotes	,
T27633	4930-4934	NN	denotes	IL-6
T27632	4925-4929	FW	denotes	e.g.
T28329	8780-8786	NN	denotes	domain
T28328	8758-8779	JJ	denotes	phosphatase-2-binding
T28327	8749-8757	NN	denotes	homology
T28326	8745-8748	NNP	denotes	Src
T28325	8741-8744	DT	denotes	the
T28324	8738-8740	TO	denotes	to
T28323	8730-8737	JJ	denotes	binding
T28322	8727-8729	IN	denotes	by
T28321	8723-8726	NNP	denotes	JAK
T28320	8720-8722	IN	denotes	of
T28319	8713-8719	NN	denotes	action
T28318	8709-8712	DT	denotes	the
T28317	8700-8708	VBZ	denotes	inhibits
T28316	8694-8699	NNP	denotes	SOCS3
T28315	8690-8693	CC	denotes	and
T28314	8688-8689	,	denotes	,
T28313	8685-8688	NNP	denotes	JAK
T28312	8682-8684	TO	denotes	to
T28311	8674-8681	JJ	denotes	binding
T28310	8665-8673	RB	denotes	directly
T28309	8662-8664	IN	denotes	by
T28308	8658-8661	NNP	denotes	JAK
T28307	8655-8657	IN	denotes	of
T28306	8644-8654	NN	denotes	activation
T28305	8635-8643	VBZ	denotes	prevents
T28304	8629-8634	CD	denotes	SOCS1
T28303	8627-8628	.	denotes	.
T28302	8622-8627	NNS	denotes	cells
T28301	8620-8621	NNP	denotes	T
T28300	8618-8619	CD	denotes	+
T28299	8615-8618	NNP	denotes	CD4
T28298	8608-8614	JJ	denotes	normal
T28297	8603-8607	IN	denotes	with
T28296	8594-8602	VBN	denotes	compared
T28295	8592-8593	,	denotes	,
T28294	8587-8592	NNP	denotes	SOCS3
T28293	8584-8586	IN	denotes	of
T28292	8577-8583	NNS	denotes	levels
T28291	8571-8576	JJR	denotes	lower
T28290	8567-8570	CC	denotes	but
T28289	8565-8566	,	denotes	,
T28288	8560-8565	NNP	denotes	SOCS1
T28287	8557-8559	IN	denotes	of
T28286	8550-8556	NNS	denotes	levels
T28285	8543-8549	JJR	denotes	higher
T28284	8533-8542	VBD	denotes	expressed
T28283	8530-8532	NNP	denotes	RA
T28282	8523-8529	JJ	denotes	active
T28281	8518-8522	IN	denotes	with
T28280	8509-8517	NNS	denotes	patients
T28279	8504-8508	IN	denotes	from
T28278	8498-8503	NNS	denotes	cells
T28277	8496-8497	NNP	denotes	T
T28276	8494-8495	CD	denotes	+
T28275	8491-8494	CD	denotes	CD4
T28274	8486-8490	IN	denotes	that
T28273	8480-8485	VBD	denotes	found
T28272	8477-8479	PRP	denotes	We
T28271	8475-8476	.	denotes	.
T27631	4924-4925	-LRB-	denotes	(
T27630	4914-4923	NNS	denotes	cytokines
T27629	4911-4913	IN	denotes	of
T27628	4904-4910	NN	denotes	family
T27627	4899-4903	NNP	denotes	IL-6
T27626	4895-4898	DT	denotes	the
T27625	4887-4894	RB	denotes	notably
T27624	4885-4886	,	denotes	,
T27623	4876-4885	NNS	denotes	cytokines
T27622	4873-4875	IN	denotes	of
T27621	4865-4872	NN	denotes	variety
T27620	4863-4864	DT	denotes	a
T27619	4860-4862	IN	denotes	by
T27618	4850-4859	VBN	denotes	activated
T27617	4847-4849	VBZ	denotes	is
T27616	4841-4846	CD	denotes	STAT3
T27615	4839-4840	.	denotes	.
T27614	4831-4839	NNS	denotes	patients
T27613	4828-4830	NNP	denotes	RA
T27612	4823-4827	IN	denotes	from
T27611	4817-4822	NNS	denotes	cells
T27610	4815-4816	NNP	denotes	T
T27609	4813-4814	VBD	denotes	+
T27608	4810-4813	NNP	denotes	CD4
T27607	4807-4809	NNP	denotes	ST
T27606	4803-4806	CC	denotes	and
T27605	4800-4802	NNP	denotes	PB
T27604	4791-4799	VBN	denotes	isolated
T27603	4783-4790	RB	denotes	freshly
T27601	4778-4779	-RRB-	denotes	)
T27600	4773-4778	NNS	denotes	hours
T27550	4439-4442	RB	denotes	not
T27549	4435-4438	CC	denotes	but
T27548	4433-4434	,	denotes	,
T27547	4423-4433	NN	denotes	activation
T27546	4417-4422	CD	denotes	STAT3
T27545	4401-4416	JJ	denotes	IL-10-dependent
T27544	4391-4400	JJ	denotes	defective
T27543	4386-4390	IN	denotes	with
T27542	4375-4385	VBN	denotes	associated
T27541	4372-4374	VB	denotes	be
T27540	4368-4371	MD	denotes	may
T27539	4362-4367	NNP	denotes	IL-10
T27538	4359-4361	TO	denotes	to
T27537	4353-4358	NNS	denotes	cells
T27536	4351-4352	NNP	denotes	T
T27535	4349-4350	VBD	denotes	+
T27534	4346-4349	NNP	denotes	CD4
T27533	4343-4345	NNP	denotes	RA
T27532	4340-4342	IN	denotes	of
T27531	4329-4339	NN	denotes	resistance
T27530	4325-4328	DT	denotes	the
T27529	4320-4324	IN	denotes	that
T27528	4307-4319	VBN	denotes	demonstrated
T27527	4302-4306	VBP	denotes	have
T27526	4299-4301	PRP	denotes	We
T27525	4297-4298	.	denotes	.
T27524	4296-4297	NNP	denotes	]
T27523	4294-4296	CD	denotes	15
T27471	3973-3975	IN	denotes	of
T27470	3964-3972	NN	denotes	ligation
T27469	3954-3963	VBG	denotes	following
T27468	3946-3953	NN	denotes	pathway
T27467	3934-3945	JJ	denotes	C-dependent
T27466	3927-3933	NN	denotes	kinase
T27465	3919-3926	NN	denotes	protein
T27464	3917-3918	DT	denotes	a
T27463	3914-3916	IN	denotes	by
T27462	3902-3913	NNS	denotes	macrophages
T27461	3889-3901	JJ	denotes	IFN-γ-primed
T27460	3886-3888	IN	denotes	in
T27459	3875-3885	VBN	denotes	suppressed
T27458	3871-3874	VBP	denotes	are
T27457	3860-3870	NN	denotes	activation
T27456	3855-3859	JJ	denotes	Jak1
T27455	3841-3854	JJ	denotes	IL-10-induced
T27454	3837-3840	CC	denotes	and
T27453	3826-3836	NN	denotes	expression
T27452	3818-3825	NN	denotes	IL-10R1
T27451	3810-3817	NN	denotes	surface
T27450	3805-3809	NN	denotes	cell
T27449	3800-3804	DT	denotes	both
T27448	3792-3799	IN	denotes	because
T27447	3790-3791	,	denotes	,
T27446	3786-3790	NN	denotes	vivo
T27445	3783-3785	IN	denotes	in
T27444	3773-3782	NNS	denotes	complexes
T27443	3766-3772	JJ	denotes	immune
T27442	3763-3765	TO	denotes	to
T27441	3754-3762	NN	denotes	exposure
T27440	3746-3753	JJ	denotes	chronic
T27439	3743-3745	IN	denotes	by
T27438	3735-3742	VBN	denotes	induced
T27437	3726-3734	RB	denotes	probably
T27436	3723-3725	VBZ	denotes	is
T27435	3713-3722	VBG	denotes	signaling
T27434	3707-3712	NN	denotes	IL-10
T27433	3698-3706	VBN	denotes	impaired
T27432	3693-3697	DT	denotes	This
T27431	3691-3692	.	denotes	.
T27430	3680-3691	NNS	denotes	macrophages
T27429	3671-3679	JJ	denotes	synovial
T27428	3668-3670	NNP	denotes	RA
T27427	3665-3667	IN	denotes	in
T27426	3652-3664	JJ	denotes	undetectable
T27425	3645-3651	RB	denotes	mostly
T27424	3642-3644	VBZ	denotes	is
T27423	3631-3641	NN	denotes	activation
T27422	3625-3630	CD	denotes	STAT3
T27421	3610-3624	JJ	denotes	IL-10-mediated
T27420	3608-3609	,	denotes	,
T27419	3597-3608	RB	denotes	importantly
T27418	3592-3596	RBR	denotes	More
T27417	3590-3591	.	denotes	.
T27416	3589-3590	NNP	denotes	]
T27415	3587-3589	CD	denotes	13
T27414	3586-3587	NNP	denotes	[
T27413	3574-3585	NNS	denotes	macrophages
T27412	3566-3573	JJ	denotes	adhered
T27411	3563-3565	IN	denotes	in
T27410	3558-3562	NNP	denotes	IL-6
T27409	3554-3557	CC	denotes	and
T27408	3548-3553	NNP	denotes	IL-10
T27407	3545-3547	IN	denotes	by
T27406	3538-3544	VBN	denotes	shared
T27405	3530-3537	NN	denotes	pathway
T27404	3520-3529	VBG	denotes	signaling
T27403	3514-3519	CD	denotes	STAT3
T27402	3509-3513	NN	denotes	Jak1
T27401	3505-3508	DT	denotes	the
T27400	3496-3504	VBZ	denotes	inhibits
T27399	3494-3495	,	denotes	,
T27398	3490-3494	NNP	denotes	IL-1
T27397	3486-3489	CC	denotes	and
T27395	3477-3479	IN	denotes	by
T27394	3469-3476	VBN	denotes	induced
T27375	3334-3336	VB	denotes	be
T27374	3331-3333	TO	denotes	to
T27373	3325-3330	VBZ	denotes	seems
T27372	3316-3324	NN	denotes	activity
T27371	3305-3315	JJ	denotes	regulatory
T27370	3300-3304	DT	denotes	this
T27369	3298-3299	,	denotes	,
T27368	3291-3298	RB	denotes	However
T27367	3289-3290	.	denotes	.
T28005	6948-6950	VB	denotes	be
T28004	6938-6947	RB	denotes	therefore
T28003	6934-6937	MD	denotes	may
T28002	6928-6933	NN	denotes	IL-10
T28001	6925-6927	IN	denotes	of
T28000	6918-6924	NN	denotes	effect
T27999	6900-6917	JJ	denotes	T-cell-inhibitory
T27998	6896-6899	DT	denotes	The
T27997	6894-6895	.	denotes	.
T27996	6893-6894	NNP	denotes	]
T27995	6891-6893	CD	denotes	32
T27994	6890-6891	NNP	denotes	[
T27993	6880-6889	VBG	denotes	signaling
T27992	6874-6879	NNP	denotes	IL-10
T27991	6871-6873	IN	denotes	of
T27990	6861-6870	NN	denotes	inhibitor
T27989	6851-6860	NN	denotes	crosstalk
T27988	6849-6850	DT	denotes	a
T27987	6846-6848	IN	denotes	as
T27986	6838-6845	NN	denotes	protein
T27985	6832-6837	CD	denotes	SOCS1
T27984	6825-6831	VB	denotes	induce
T27983	6821-6824	MD	denotes	can
T27982	6815-6820	NN	denotes	IFN-γ
T27981	6811-6814	CC	denotes	and
T27980	6800-6810	NN	denotes	activation
T27979	6794-6799	JJ	denotes	STAT3
T27978	6784-6793	VB	denotes	stimulate
T27977	6771-6783	RB	denotes	persistently
T27976	6767-6770	MD	denotes	may
T27975	6761-6766	NN	denotes	IL-10
T27974	6759-6760	,	denotes	,
T27973	6752-6759	NN	denotes	fashion
T27972	6742-6751	NN	denotes	autocrine
T27971	6739-6741	DT	denotes	an
T27970	6736-6738	IN	denotes	In
T27969	6734-6735	.	denotes	.
T27942	6580-6588	VBN	denotes	produced
T27941	6574-6579	NNP	denotes	IL-10
T27940	6570-6573	CC	denotes	and
T27939	6564-6569	NNP	denotes	IFN-γ
T27938	6562-6563	,	denotes	,
T27937	6551-6562	RB	denotes	Furthermore
T27936	6549-6550	.	denotes	.
T27935	6548-6549	-RRB-	denotes	)
T27934	6543-6548	VBN	denotes	shown
T27933	6539-6542	RB	denotes	not
T27932	6534-6538	NNS	denotes	data
T27931	6533-6534	-LRB-	denotes	(
T27930	6528-6532	NNP	denotes	IL-6
T27929	6525-6527	IN	denotes	by
T27928	6520-6524	IN	denotes	than
T27927	6508-6519	RB	denotes	effectively
T27926	6503-6507	JJR	denotes	less
T27925	6494-6502	IN	denotes	although
T27924	6492-6493	,	denotes	,
T27923	6487-6492	JJ	denotes	TNF-α
T27922	6483-6486	CC	denotes	and
T27921	6477-6482	JJ	denotes	IL-1β
T27920	6472-6476	IN	denotes	with
T27919	6459-6471	NN	denotes	pretreatment
T27918	6456-6458	IN	denotes	by
T27917	6448-6455	VBN	denotes	reduced
T27916	6444-6447	VBD	denotes	was
T27915	6438-6443	NNS	denotes	cells
T27914	6436-6437	NNP	denotes	T
T27913	6434-6435	NNP	denotes	+
T27912	6431-6434	NNP	denotes	CD4
T27911	6428-6430	IN	denotes	in
T27910	6417-6427	NN	denotes	inhibition
T27909	6411-6416	JJ	denotes	IFN-γ
T27908	6396-6410	JJ	denotes	IL-10-mediated
T27907	6391-6395	IN	denotes	that
T27906	6377-6390	VBG	denotes	demonstrating
T27905	6365-6376	NNS	denotes	experiments
T27838	5983-5989	VBD	denotes	showed
T27837	5978-5982	RB	denotes	also
T27836	5975-5977	NNP	denotes	RA
T27835	5972-5974	IN	denotes	of
T27834	5969-5971	NNP	denotes	ST
T27833	5965-5968	DT	denotes	the
T27832	5960-5964	IN	denotes	from
T27831	5951-5959	VBD	denotes	isolated
T27830	5945-5950	NNS	denotes	cells
T27829	5943-5944	NNP	denotes	T
T27828	5941-5942	CD	denotes	+
T27827	5938-5941	CD	denotes	CD4
T27826	5936-5937	.	denotes	.
T27825	5935-5936	NNP	denotes	]
T27824	5933-5935	CD	denotes	34
T27823	5932-5933	NNP	denotes	[
T27822	5926-5931	NNP	denotes	IL-10
T27821	5923-5925	IN	denotes	of
T27820	5916-5922	NNS	denotes	levels
T27819	5904-5915	JJ	denotes	significant
T27818	5894-5903	VBG	denotes	producing
T27817	5891-5893	IN	denotes	of
T27816	5883-5890	JJ	denotes	capable
T27366	3288-3289	NNP	denotes	]
T27365	3286-3288	CD	denotes	12
T27364	3285-3286	NNP	denotes	[
T27363	3279-3284	NNS	denotes	cells
T27362	3276-3278	NNP	denotes	ST
T27361	3273-3275	IN	denotes	by
T27360	3262-3272	NN	denotes	production
T27359	3253-3261	NN	denotes	cytokine
T27358	3237-3252	JJ	denotes	proinflammatory
T27357	3228-3236	VBZ	denotes	inhibits
T27356	3226-3227	,	denotes	,
T27355	3221-3226	NNS	denotes	cells
T27354	3219-3220	NNP	denotes	T
T27353	3215-3218	CC	denotes	and
T27352	3203-3214	NNS	denotes	macrophages
T27351	3200-3202	IN	denotes	by
T27350	3193-3199	RB	denotes	mainly
T27349	3184-3192	VBD	denotes	produced
T27348	3182-3183	,	denotes	,
T27347	3177-3182	NNP	denotes	IL-10
T27346	3166-3176	NNP	denotes	Endogenous
T27345	3164-3165	.	denotes	.
T27344	3163-3164	NNP	denotes	]
T27343	3161-3163	CD	denotes	10
T27342	3160-3161	NNP	denotes	[
T27341	3151-3159	NN	denotes	severity
T27340	3143-3150	NN	denotes	disease
T27339	3133-3142	VBZ	denotes	regulates
T27338	3122-3132	NNS	denotes	activities
T27337	3113-3121	NN	denotes	cytokine
T27336	3104-3112	VBG	denotes	opposing
T27335	3098-3103	DT	denotes	these
T27246	2591-2594	CC	denotes	and
T27245	2586-2590	NNP	denotes	CD80
T27244	2584-2585	,	denotes	,
T27243	2575-2584	NNS	denotes	cytokines
T27242	2572-2574	IN	denotes	of
T27241	2565-2571	NNS	denotes	levels
T27240	2560-2564	JJ	denotes	high
T27239	2552-2559	VB	denotes	express
T27238	2549-2551	NNP	denotes	ST
T27237	2545-2548	DT	denotes	the
T27236	2542-2544	IN	denotes	in
T27235	2530-2541	NNS	denotes	macrophages
T27234	2522-2529	IN	denotes	because
T27233	2520-2521	,	denotes	,
T27232	2518-2520	NNP	denotes	RA
T27231	2515-2517	IN	denotes	in
T27230	2504-2514	NN	denotes	activation
T27229	2497-2503	NNP	denotes	T-cell
T27228	2494-2496	IN	denotes	of
T27227	2489-2493	NN	denotes	site
T27226	2485-2488	DT	denotes	the
T27225	2482-2484	IN	denotes	at
T27224	2471-2481	VBN	denotes	restricted
T27223	2468-2470	VB	denotes	be
T27222	2465-2467	TO	denotes	to
T27221	2457-2464	VBN	denotes	thought
T27220	2454-2456	VBZ	denotes	is
T27219	2447-2453	NN	denotes	effect
T27218	2436-2446	JJ	denotes	inhibitory
T27217	2427-2435	JJ	denotes	indirect
T27216	2422-2426	DT	denotes	this
T27215	2420-2421	,	denotes	,
T27214	2413-2420	RB	denotes	However
T27213	2411-2412	.	denotes	.
T27212	2410-2411	NNP	denotes	]
T27211	2409-2410	CD	denotes	1
T27210	2408-2409	NNP	denotes	[
T27209	2399-2407	NN	denotes	function
T27208	2394-2398	NN	denotes	cell
T27207	2375-2393	JJ	denotes	antigen-presenting
T27206	2364-2374	NN	denotes	macrophage
T27205	2361-2363	IN	denotes	of
T27204	2350-2360	NN	denotes	inhibition
T27203	2346-2349	PRP$	denotes	its
T27202	2343-2345	IN	denotes	on
T27201	2333-2342	JJ	denotes	dependent
T27200	2321-2332	RB	denotes	principally
T27199	2318-2320	VBZ	denotes	is
T27198	2307-2317	NN	denotes	production
T27197	2298-2306	NN	denotes	cytokine
T27196	2291-2297	NNP	denotes	T-cell
T27195	2289-2290	NNP	denotes	+
T27194	2286-2289	NNP	denotes	CD4
T27193	2283-2285	IN	denotes	of
T27192	2272-2282	NN	denotes	inhibition
T27191	2257-2271	JJ	denotes	IL-10-mediated
T27186	2220-2235	NN	denotes	phosphorylation
T27185	2214-2219	NNP	denotes	STAT3
T27184	2204-2213	VBN	denotes	sustained
T27181	2184-2186	IN	denotes	in
T27180	2182-2183	,	denotes	,
T27179	2172-2182	NN	denotes	activation
T27178	2166-2171	CD	denotes	STAT3
T27177	2150-2165	JJ	denotes	IL-10-dependent
T27176	2141-2149	VBN	denotes	impaired
T27175	2138-2140	TO	denotes	to
T27174	2125-2137	JJ	denotes	attributable
T27173	2122-2124	VB	denotes	be
T27172	2118-2121	MD	denotes	may
T27171	2107-2117	NN	denotes	resistance
T27170	2102-2106	DT	denotes	this
T27169	2097-2101	IN	denotes	that
T27168	2089-2096	VBP	denotes	suggest
T27167	2085-2088	CC	denotes	and
T27166	2083-2084	,	denotes	,
T27165	2081-2083	NNP	denotes	ST
T27164	2072-2080	JJ	denotes	inflamed
T27163	2068-2071	DT	denotes	the
T27162	2063-2067	IN	denotes	into
T27161	2053-2062	NN	denotes	migration
T27160	2046-2052	IN	denotes	before
T27159	2040-2045	NN	denotes	IL-10
T27158	2037-2039	IN	denotes	of
T27157	2030-2036	NN	denotes	effect
T27156	2019-2029	JJ	denotes	inhibitory
T27155	2015-2018	DT	denotes	the
T27154	2012-2014	TO	denotes	to
T27153	2002-2011	JJ	denotes	resistant
T27152	1995-2001	VBP	denotes	become
T27151	1989-1994	NNS	denotes	cells
T27150	1987-1988	NNP	denotes	T
T27149	1985-1986	CD	denotes	+
T27148	1982-1985	CD	denotes	CD4
T27147	1977-1981	IN	denotes	that
T27146	1968-1976	VBP	denotes	indicate
T27145	1959-1967	NNS	denotes	findings
T27144	1953-1958	DT	denotes	These
T27143	1951-1952	.	denotes	.
T27142	1946-1951	NNS	denotes	cells
T27141	1944-1945	NNP	denotes	T
T27140	1942-1943	CD	denotes	+
T27139	1939-1942	NNP	denotes	CD4
T27138	1932-1938	JJ	denotes	normal
T27137	1927-1931	IN	denotes	with
T27136	1916-1926	NN	denotes	comparison
T27135	1913-1915	IN	denotes	in
T27134	1901-1912	NNS	denotes	transcripts
T27133	1895-1900	CD	denotes	SOCS3
T27132	1892-1894	IN	denotes	of
T27131	1885-1891	NNS	denotes	levels
T27130	1879-1884	JJR	denotes	lower
T27129	1871-1878	VBP	denotes	contain
T27128	1867-1870	CC	denotes	but
T27127	1861-1866	CD	denotes	SOCS1
T27126	1858-1860	IN	denotes	of
T27125	1851-1857	NNS	denotes	levels
T27124	1844-1850	JJR	denotes	higher
T27123	1836-1843	VBP	denotes	contain
T27122	1830-1835	NNS	denotes	cells
T27121	1828-1829	NNP	denotes	T
T27120	1826-1827	VBD	denotes	+
T27119	1823-1826	NNP	denotes	CD4
T27118	1820-1822	NNP	denotes	RA
T27117	1818-1819	.	denotes	.
T27116	1808-1818	NN	denotes	production
T27115	1802-1807	JJ	denotes	IFN-γ
T27114	1799-1801	IN	denotes	of
T27113	1788-1798	NN	denotes	inhibition
T27112	1782-1787	NNP	denotes	IL-10
T27111	1779-1781	TO	denotes	to
T27110	1768-1778	NN	denotes	resistance
T27109	1764-1767	DT	denotes	the
T27108	1756-1763	VBZ	denotes	induces
T27107	1751-1755	NN	denotes	IL-6
T27106	1741-1750	JJ	denotes	exogenous
T27105	1737-1740	CC	denotes	and
T27104	1735-1736	,	denotes	,
T27103	1730-1735	NNS	denotes	cells
T27102	1728-1729	NNP	denotes	T
T27101	1726-1727	CD	denotes	+
T27100	1723-1726	NNP	denotes	CD4
T27099	1716-1722	JJ	denotes	normal
T27098	1713-1715	IN	denotes	in
T27097	1697-1712	NN	denotes	phosphorylation
T27096	1691-1696	CD	denotes	STAT1
T27095	1687-1690	RB	denotes	not
T27094	1683-1686	CC	denotes	but
T27093	1677-1682	CD	denotes	STAT3
T27092	1669-1676	VBZ	denotes	induces
T27091	1660-1668	NNS	denotes	patients
T27090	1657-1659	NNP	denotes	RA
T27089	1652-1656	IN	denotes	from
T27088	1647-1651	NNP	denotes	IL-6
T27072	1552-1558	JJ	denotes	normal
T27071	1549-1551	TO	denotes	to
T27070	1540-1548	NN	denotes	contrast
T27069	1537-1539	IN	denotes	in
T27068	1535-1536	,	denotes	,
T27067	1530-1535	NNS	denotes	cells
T27066	1528-1529	NNP	denotes	T
T27065	1526-1527	VBD	denotes	+
T27064	1523-1526	NNP	denotes	CD4
T27063	1520-1522	NNP	denotes	RA
T28054	7248-7249	NNP	denotes	]
T28053	7246-7248	CD	denotes	36
T28052	7245-7246	NNP	denotes	[
T28051	7236-7244	NNS	denotes	patients
T28050	7233-7235	NNP	denotes	RA
T28049	7228-7232	IN	denotes	from
T28048	7222-7227	NNS	denotes	cells
T28047	7210-7221	NN	denotes	mononuclear
T28046	7204-7209	NN	denotes	fluid
T28045	7195-7203	JJ	denotes	synovial
T28044	7192-7194	IN	denotes	in
T28043	7182-7191	VBN	denotes	expressed
T28042	7167-7181	RB	denotes	constitutively
T28041	7164-7166	VBZ	denotes	is
T28040	7158-7163	NNP	denotes	STAT3
T28039	7151-7157	JJ	denotes	Active
T28038	7149-7150	.	denotes	.
T28037	7147-7149	NNP	denotes	RA
T28036	7144-7146	IN	denotes	of
T28035	7131-7143	NN	denotes	pathogenesis
T28034	7127-7130	DT	denotes	the
T28033	7124-7126	IN	denotes	in
T28032	7113-7123	VBN	denotes	implicated
T28031	7108-7112	VBN	denotes	been
T28030	7104-7107	VBZ	denotes	has
T28029	7093-7103	NN	denotes	activation
T28028	7087-7092	CD	denotes	STAT3
T28027	7085-7086	.	denotes	.
T28026	7084-7085	NNP	denotes	]
T28025	7082-7084	CD	denotes	10
T28024	7081-7082	NNP	denotes	[
T28023	7067-7080	RB	denotes	substantially
T28022	7059-7066	JJ	denotes	present
T28021	7055-7058	VBP	denotes	are
T28020	7045-7054	NNS	denotes	cytokines
T28019	7040-7044	JJ	denotes	many
T28018	7034-7039	WRB	denotes	where
T28017	7032-7033	,	denotes	,
T28016	7026-7032	NNS	denotes	joints
T28015	7023-7025	NNP	denotes	RA
T28014	7020-7022	IN	denotes	in
T28013	7008-7019	NN	denotes	environment
T28012	6995-7007	JJ	denotes	inflammatory
T28011	6992-6994	DT	denotes	an
T28010	6989-6991	TO	denotes	to
T28009	6980-6988	NN	denotes	exposure
T28008	6975-6979	IN	denotes	upon
T28007	6961-6974	RB	denotes	complicatedly
T28006	6951-6960	VBN	denotes	modulated
T27599	4771-4772	CD	denotes	6
T27598	4768-4770	TO	denotes	to
T27597	4765-4767	IN	denotes	up
T27596	4764-4765	-LRB-	denotes	(
T27595	4751-4763	RB	denotes	persistently
T27594	4736-4750	VBN	denotes	phosphorylated
T27593	4727-4735	JJ	denotes	tyrosine
T27592	4724-4726	VB	denotes	be
T27591	4721-4723	TO	denotes	to
T27590	4715-4720	VBN	denotes	found
T27589	4711-4714	VBD	denotes	was
T27588	4705-4710	NNP	denotes	STAT3
T27587	4703-4704	,	denotes	,
T27586	4693-4703	NN	denotes	activation
T27585	4687-4692	CD	denotes	STAT3
T27584	4672-4686	JJ	denotes	IL-10-mediated
T27583	4663-4671	JJ	denotes	impaired
T27582	4658-4662	IN	denotes	with
T27581	4646-4657	NN	denotes	association
T27580	4643-4645	IN	denotes	In
T27579	4641-4642	.	denotes	.
T27578	4639-4641	NNP	denotes	RA
T27577	4636-4638	IN	denotes	in
T27576	4624-4635	NN	denotes	environment
T27575	4611-4623	JJ	denotes	inflammatory
T27574	4607-4610	DT	denotes	the
T27573	4601-4606	IN	denotes	under
T27572	4595-4600	NN	denotes	level
T27571	4582-4594	NN	denotes	transduction
T27570	4575-4581	NN	denotes	signal
T27569	4571-4574	DT	denotes	the
T27568	4568-4570	IN	denotes	at
T27567	4558-4567	VBN	denotes	modulated
T27566	4543-4557	RB	denotes	differentially
T27565	4533-4542	RB	denotes	therefore
T27564	4529-4532	VBP	denotes	are
T27563	4523-4528	NNS	denotes	types
T27562	4518-4522	NN	denotes	cell
T27561	4505-4517	JJ	denotes	inflammatory
T27560	4499-4504	DT	denotes	these
T27559	4496-4498	IN	denotes	on
T27558	4490-4495	NN	denotes	IL-10
T27557	4487-4489	IN	denotes	of
T27556	4479-4486	NNS	denotes	effects
T27555	4468-4478	NNP	denotes	Inhibitory
T27554	4466-4467	.	denotes	.
T27553	4456-4466	NN	denotes	expression
T27552	4448-4455	JJ	denotes	IL-10R1
T27551	4443-4447	IN	denotes	with
T27062	1517-1519	IN	denotes	in
T27061	1506-1516	VBN	denotes	suppressed
T27060	1503-1505	VBZ	denotes	is
T27059	1497-1502	CD	denotes	STAT3
T27058	1494-1496	IN	denotes	of
T27057	1478-1493	NN	denotes	phosphorylation
T27056	1469-1477	NN	denotes	tyrosine
T27055	1455-1468	JJ	denotes	IL-10-induced
T27054	1453-1454	,	denotes	,
T27053	1443-1453	NN	denotes	activation
T27052	1437-1442	CD	denotes	STAT3
T27051	1424-1436	JJ	denotes	constitutive
T27050	1420-1423	CC	denotes	and
T27049	1409-1419	NN	denotes	expression
T27048	1401-1408	NN	denotes	IL-10R1
T27047	1390-1400	JJ	denotes	high-level
T27046	1382-1389	IN	denotes	Despite
T27045	1380-1381	.	denotes	.
T27044	1375-1380	NNS	denotes	cells
T27043	1373-1374	NNP	denotes	T
T27042	1371-1372	CD	denotes	+
T27041	1368-1371	NNP	denotes	CD4
T27040	1361-1367	JJ	denotes	normal
T27039	1356-1360	IN	denotes	than
T27038	1342-1355	NN	denotes	costimulation
T27037	1337-1341	NNP	denotes	CD28
T27036	1333-1336	CC	denotes	and
T27035	1329-1332	NNP	denotes	CD3
T27034	1323-1328	IN	denotes	after
T27033	1317-1322	JJ	denotes	IFN-γ
T27032	1314-1316	IN	denotes	of
T27031	1307-1313	NNS	denotes	levels
T27334	3090-3097	IN	denotes	between
T27333	3082-3089	NN	denotes	balance
T27332	3078-3081	DT	denotes	the
T27331	3074-3077	CC	denotes	and
T27330	3072-3073	,	denotes	,
T27329	3070-3072	NNP	denotes	RA
T27328	3067-3069	IN	denotes	of
T27327	3064-3066	NNP	denotes	ST
T27326	3060-3063	DT	denotes	the
T27325	3057-3059	IN	denotes	in
T27324	3048-3056	VBN	denotes	detected
T27323	3043-3047	VBN	denotes	been
T27322	3038-3042	VBP	denotes	have
T27321	3036-3037	,	denotes	,
T27320	3019-3036	JJ	denotes	anti-inflammatory
T27319	3015-3018	CC	denotes	and
T27318	2999-3014	JJ	denotes	proinflammatory
T27317	2994-2998	DT	denotes	both
T27316	2992-2993	,	denotes	,
T27315	2983-2992	NNS	denotes	cytokines
T27314	2974-2982	JJ	denotes	Numerous
T27313	2972-2973	.	denotes	.
T27312	2968-2972	NNP	denotes	IL-2
T27311	2964-2967	CC	denotes	and
T27310	2958-2963	NNP	denotes	IFN-γ
T27309	2953-2957	DT	denotes	both
T27308	2950-2952	IN	denotes	of
T27307	2939-2949	NN	denotes	production
T27306	2921-2938	JJ	denotes	CD28-costimulated
T27279	2787-2788	NNP	denotes	]
T27278	2785-2787	CD	denotes	33
T27277	2784-2785	NNP	denotes	[
T27276	2768-2783	NN	denotes	phosphorylation
T27275	2759-2767	NN	denotes	tyrosine
T27274	2754-2758	NNP	denotes	CD28
T27273	2743-2753	VBG	denotes	inhibiting
T27272	2740-2742	IN	denotes	by
T27271	2723-2739	NN	denotes	unresponsiveness
T27270	2716-2722	NN	denotes	T-cell
T27269	2699-2715	JJ	denotes	antigen-specific
T27268	2695-2698	DT	denotes	the
T27267	2688-2694	VB	denotes	induce
T27266	2685-2687	TO	denotes	to
T27265	2679-2684	VBN	denotes	shown
T27264	2674-2678	VBN	denotes	been
T27263	2670-2673	VBZ	denotes	has
T27262	2664-2669	NNP	denotes	IL-10
T27261	2662-2663	,	denotes	,
T27260	2654-2662	RB	denotes	recently
T27259	2649-2653	RBR	denotes	More
T27258	2647-2648	.	denotes	.
T27257	2646-2647	NNP	denotes	]
T27256	2638-2646	CD	denotes	10,18-20
T27255	2637-2638	NNP	denotes	[
T27254	2628-2636	VBZ	denotes	antigens
T27253	2625-2627	NNP	denotes	II
T27252	2619-2624	NN	denotes	class
T27251	2615-2618	NNP	denotes	MHC
T27250	2611-2614	CC	denotes	and
T27249	2609-2610	,	denotes	,
T27248	2600-2609	NNS	denotes	molecules
T27247	2595-2599	NNP	denotes	CD86
T27030	1300-1306	JJR	denotes	higher
T27029	1292-1299	VB	denotes	produce
T27028	1289-1291	TO	denotes	to
T27027	1284-1288	JJ	denotes	able
T27026	1280-1283	VBP	denotes	are
T27025	1278-1279	,	denotes	,
T27024	1273-1278	NNP	denotes	IL-10
T27023	1270-1272	IN	denotes	of
T27022	1261-1269	NN	denotes	presence
T27021	1257-1260	DT	denotes	the
T27020	1254-1256	IN	denotes	in
T27019	1252-1253	,	denotes	,
T27018	1250-1252	NNP	denotes	RA
T27017	1243-1249	JJ	denotes	active
T27016	1238-1242	IN	denotes	with
T27015	1229-1237	NNS	denotes	patients
T27014	1224-1228	IN	denotes	from
T27013	1218-1223	NNS	denotes	cells
T27012	1216-1217	NNP	denotes	T
T27011	1214-1215	VBD	denotes	+
T27010	1211-1214	NNP	denotes	CD4
T27009	1208-1210	NNP	denotes	PB
T26948	864-865	DT	denotes	a
T26947	858-863	VBZ	denotes	plays
T26946	852-857	NN	denotes	IL-10
T26945	850-851	.	denotes	.
T26944	849-850	NNP	denotes	]
T26943	847-849	CD	denotes	23
T26942	846-847	NNP	denotes	[
T26941	837-845	NNS	denotes	patients
T26940	834-836	NNP	denotes	RA
T26939	831-833	IN	denotes	in
T26938	827-830	NNP	denotes	IgG
T26937	826-827	:	denotes	-
T26936	825-826	-RRB-	denotes	)
T26935	820-825	NN	denotes	CD152
T26934	819-820	-LRB-	denotes	(
T26933	817-818	CD	denotes	4
T26932	809-816	NN	denotes	antigen
T26931	791-808	JJ	denotes	T-cell-associated
T26930	781-790	JJ	denotes	cytotoxic
T26929	773-780	NN	denotes	blocker
T26928	769-772	PRP$	denotes	its
T26927	766-768	IN	denotes	of
T26926	757-765	NN	denotes	efficacy
T26925	748-756	JJ	denotes	clinical
T26924	744-747	DT	denotes	the
T26923	741-743	IN	denotes	by
T26922	734-740	VBN	denotes	proven
T26921	729-733	VBN	denotes	been
T26920	720-728	RB	denotes	recently
T26919	716-719	VBZ	denotes	has
T26918	708-715	NN	denotes	process
T26917	700-707	NN	denotes	disease
T26916	684-699	JJ	denotes	T-cell-mediated
T26915	680-683	DT	denotes	the
T26914	677-679	IN	denotes	in
T26913	666-676	NN	denotes	engagement
T26912	661-665	CD	denotes	CD28
T26911	658-660	IN	denotes	of
T26910	645-657	NN	denotes	significance
T26909	641-644	DT	denotes	The
T26908	639-640	.	denotes	.
T26907	638-639	NNP	denotes	]
T26906	633-638	CD	denotes	18-20
T26905	632-633	NNP	denotes	[
T26904	626-631	NNS	denotes	cells
T26903	616-625	JJ	denotes	dendritic
T26902	612-615	CC	denotes	and
T26901	600-611	NNS	denotes	macrophages
T26900	597-599	IN	denotes	as
T26899	592-596	JJ	denotes	such
T26898	586-591	NNS	denotes	cells
T26897	567-585	JJ	denotes	antigen-presenting
T26896	564-566	IN	denotes	by
T26895	554-563	VBN	denotes	expressed
T26894	540-553	RB	denotes	substantially
T26893	536-539	VBP	denotes	are
T26892	534-535	,	denotes	,
T26891	526-534	NNS	denotes	antigens
T26890	523-525	NNP	denotes	II
T26889	517-522	NN	denotes	class
T26888	513-516	NNP	denotes	MHC
T26887	508-512	IN	denotes	with
T26886	499-507	RB	denotes	together
T26885	497-498	,	denotes	,
T26884	493-497	NNP	denotes	CD86
T26883	489-492	CC	denotes	and
T26882	484-488	NNP	denotes	CD80
T26881	479-483	DT	denotes	both
T26880	477-478	,	denotes	,
T26879	470-477	NNS	denotes	ligands
T26878	465-469	NNP	denotes	CD28
T26877	461-464	DT	denotes	the
T26876	459-460	,	denotes	,
T26875	453-459	NN	denotes	lesion
T26874	450-452	NNP	denotes	ST
T26873	446-449	DT	denotes	the
T26872	443-445	IN	denotes	In
T26871	441-442	.	denotes	.
T26870	428-441	NN	denotes	costimulation
T26869	414-427	JJ	denotes	CD28-mediated
T26868	410-413	CC	denotes	and
T26867	400-409	NN	denotes	occupancy
T26866	391-399	NN	denotes	receptor
T26865	383-390	NN	denotes	antigen
T26864	381-382	:	denotes	;
T26863	372-381	VBN	denotes	activated
T26862	369-371	VB	denotes	be
T26861	366-368	TO	denotes	to
T26860	358-365	NNS	denotes	signals
T26859	354-357	CD	denotes	two
T26858	346-353	VBP	denotes	require
T26857	340-345	NNS	denotes	cells
T26856	338-339	NNP	denotes	T
T26855	336-337	CD	denotes	+
T26854	333-336	CD	denotes	CD4
T26853	331-332	.	denotes	.
T26852	320-331	NN	denotes	destruction
T26851	314-319	JJ	denotes	joint
T26850	310-313	DT	denotes	the
T26849	306-309	CC	denotes	and
T26848	293-305	NN	denotes	inflammation
T26847	285-292	NN	denotes	chronic
T26846	281-284	DT	denotes	the
T26845	276-280	DT	denotes	both
T26844	273-275	TO	denotes	to
T26843	260-272	VBG	denotes	contributing
T26842	252-259	RB	denotes	thereby
T26841	250-251	,	denotes	,
T26840	241-250	NNS	denotes	cytokines
T26839	237-240	JJ	denotes	Th1
T26838	233-236	CC	denotes	and
T26837	223-232	NNS	denotes	molecules
T26836	215-222	NN	denotes	surface
T26835	210-214	NN	denotes	cell
T26834	207-209	IN	denotes	of
T26833	196-206	NN	denotes	expression
T26832	192-195	DT	denotes	the
T26831	184-191	IN	denotes	through
T26830	172-183	NNS	denotes	osteoclasts
T26829	168-171	CC	denotes	and
T26828	166-167	,	denotes	,
T26827	161-166	NNS	denotes	cells
T26826	159-160	NNP	denotes	B
T26825	157-158	,	denotes	,
T26824	146-157	NNS	denotes	fibroblasts
T26823	137-145	JJ	denotes	synovial
T26822	135-136	,	denotes	,
T26821	124-135	NNS	denotes	macrophages
T26820	114-123	VBP	denotes	stimulate
T26819	108-113	NNS	denotes	cells
T26818	106-107	NNP	denotes	T
T26817	104-105	CD	denotes	+
T26816	101-104	NNP	denotes	CD4
T26815	91-100	VBN	denotes	Activated
T26814	89-90	.	denotes	.
T26813	88-89	NNP	denotes	]
T26812	86-88	CD	denotes	22
T26811	85-86	NNP	denotes	[
T26810	82-84	NNP	denotes	RA
T26809	79-81	IN	denotes	in
T26808	70-78	NN	denotes	response
T26807	63-69	JJ	denotes	immune
T26806	49-62	JJ	denotes	cell-mediated
T26805	40-48	JJ	denotes	Th1-type
T26804	36-39	DT	denotes	the
T26803	24-35	VBP	denotes	orchestrate
T26802	18-23	NNS	denotes	cells
T26801	16-17	NNP	denotes	T
T26800	14-15	CD	denotes	+
T26799	11-14	CD	denotes	CD4
T26972	1001-1009	VBZ	denotes	inhibits
T26971	995-1000	NN	denotes	IL-10
T26970	993-994	.	denotes	.
T26969	992-993	NNP	denotes	]
T26968	991-992	CD	denotes	1
T26967	990-991	VBP	denotes	[
T26966	984-989	NNS	denotes	cells
T26965	980-983	JJ	denotes	Th1
T26964	976-979	CC	denotes	and
T26963	964-975	NNS	denotes	macrophages
T26962	959-963	DT	denotes	both
T26961	956-958	IN	denotes	of
T26960	947-955	NN	denotes	function
T26959	943-946	DT	denotes	the
T26958	932-942	VBG	denotes	regulating
T26957	929-931	IN	denotes	by
T26956	919-928	NNS	denotes	responses
T26955	906-918	JJ	denotes	inflammatory
T26954	902-905	CC	denotes	and
T26953	895-901	JJ	denotes	immune
T26952	886-894	VBG	denotes	limiting
T26951	883-885	IN	denotes	in
T26950	878-882	NN	denotes	role
T26949	866-877	JJ	denotes	predominant
T26991	1133-1140	RB	denotes	thereby
T26990	1129-1132	CC	denotes	and
T26989	1127-1128	,	denotes	,
T26988	1122-1127	NNS	denotes	cells
T26987	1120-1121	NNP	denotes	T
T26986	1117-1119	IN	denotes	in
T26985	1109-1116	JJ	denotes	binding
T26984	1100-1108	JJ	denotes	3-kinase
T26983	1079-1099	NN	denotes	phosphatidylinositol
T26982	1068-1078	JJ	denotes	subsequent
T26981	1064-1067	DT	denotes	the
T26980	1060-1063	CC	denotes	and
T26979	1051-1059	NN	denotes	molecule
T26978	1046-1050	NNP	denotes	CD28
T26977	1042-1045	DT	denotes	the
T26976	1039-1041	IN	denotes	of
T26975	1023-1038	NN	denotes	phosphorylation
T26974	1014-1022	NN	denotes	tyrosine
T26973	1010-1013	DT	denotes	the
T27008	1203-1207	IN	denotes	that
T27007	1197-1202	VBD	denotes	found
T27006	1194-1196	PRP	denotes	we
T27005	1192-1193	,	denotes	,
T27004	1187-1192	NN	denotes	study
T27003	1179-1186	JJ	denotes	present
T27002	1175-1178	DT	denotes	the
T27001	1172-1174	IN	denotes	In
T27000	1170-1171	.	denotes	.
T26999	1169-1170	NNP	denotes	]
T26998	1167-1169	CD	denotes	24
T26997	1166-1167	NNP	denotes	[
T26996	1160-1165	NNS	denotes	cells
T26995	1158-1159	NNP	denotes	T
T26994	1155-1157	IN	denotes	on
T26993	1150-1154	VBZ	denotes	acts
T26992	1141-1149	RB	denotes	directly
T27087	1641-1646	NNP	denotes	Serum
T27086	1639-1640	.	denotes	.
T27085	1634-1639	NNP	denotes	IL-10
T27084	1631-1633	IN	denotes	by
T27083	1621-1630	JJ	denotes	inducible
T27082	1604-1620	RB	denotes	dose-dependently
T27081	1601-1603	VBZ	denotes	is
T27080	1585-1600	NN	denotes	phosphorylation
T27079	1579-1584	NNP	denotes	STAT3
T27078	1573-1578	WRB	denotes	where
T27077	1571-1572	,	denotes	,
T27076	1566-1571	NNS	denotes	cells
T27075	1564-1565	NNP	denotes	T
T27074	1562-1563	CD	denotes	+
T27073	1559-1562	NNP	denotes	CD4
T27183	2199-2203	IN	denotes	with
T27182	2187-2198	NN	denotes	association
T27190	2255-2256	.	denotes	.
T27189	2246-2255	NN	denotes	induction
T27188	2240-2245	CD	denotes	SOCS1
T27187	2236-2239	CC	denotes	and
T27291	2842-2850	NNS	denotes	patients
T27290	2839-2841	NNP	denotes	RA
T27289	2832-2838	JJ	denotes	active
T27288	2829-2831	IN	denotes	in
T27287	2821-2828	VBN	denotes	limited
T27286	2818-2820	VB	denotes	be
T27285	2814-2817	MD	denotes	may
T27284	2809-2813	RB	denotes	also
T27283	2802-2808	NN	denotes	effect
T27282	2795-2801	JJ	denotes	direct
T27281	2790-2794	DT	denotes	This
T27280	2788-2789	.	denotes	.
T27305	2918-2920	IN	denotes	of
T27304	2907-2917	NN	denotes	inhibition
T27303	2901-2906	NN	denotes	IL-10
T27302	2891-2900	JJ	denotes	defective
T27301	2889-2890	DT	denotes	a
T27300	2882-2888	VBD	denotes	showed
T27299	2876-2881	NNS	denotes	cells
T27298	2874-2875	NNP	denotes	T
T27297	2872-2873	VBD	denotes	+
T27296	2869-2872	NNP	denotes	CD4
T27295	2866-2868	NNP	denotes	PB
T27294	2860-2865	PRP$	denotes	their
T27293	2852-2859	IN	denotes	because
T27292	2850-2851	,	denotes	,
T27393	3467-3468	,	denotes	,
T27392	3459-3467	NNS	denotes	pathways
T27391	3452-3458	NN	denotes	kinase
T27390	3448-3451	JJ	denotes	p38
T27389	3444-3447	CC	denotes	and
T27388	3437-3443	NN	denotes	kinase
T27387	3418-3436	JJ	denotes	stimulus-regulated
T27386	3404-3417	JJ	denotes	extracellular
T27385	3400-3403	DT	denotes	the
T27384	3395-3399	DT	denotes	both
T27383	3392-3394	IN	denotes	of
T27382	3381-3391	NN	denotes	activation
T27381	3377-3380	DT	denotes	The
T27380	3375-3376	.	denotes	.
T27379	3363-3375	NN	denotes	inflammation
T27378	3355-3362	JJ	denotes	chronic
T27377	3348-3354	IN	denotes	during
T27376	3337-3347	VBN	denotes	restricted
T27396	3480-3485	NNP	denotes	TNF-α
T27495	4106-4108	IN	denotes	of
T27494	4099-4105	NN	denotes	effect
T27493	4082-4098	JJ	denotes	immunoregulatory
T27492	4078-4081	DT	denotes	the
T27491	4075-4077	TO	denotes	to
T27490	4065-4074	JJ	denotes	resistant
T27489	4061-4064	VBP	denotes	are
T27488	4054-4060	NNS	denotes	fluids
T27487	4045-4053	JJ	denotes	synovial
T27486	4042-4044	NNP	denotes	RA
T27485	4037-4041	IN	denotes	from
T27484	4031-4036	NNS	denotes	cells
T27483	4021-4030	JJ	denotes	dendritic
T27482	4019-4020	,	denotes	,
T27481	4008-4019	RB	denotes	Furthermore
T27480	4006-4007	.	denotes	.
T27479	4005-4006	NNP	denotes	]
T27478	4003-4005	CD	denotes	14
T27477	4002-4003	NNP	denotes	[
T27476	3993-4001	NN	denotes	receptor
T27475	3987-3992	NN	denotes	gamma
T27474	3984-3986	NNP	denotes	Fc
T27473	3980-3983	NNP	denotes	IgG
T27472	3976-3979	DT	denotes	the
T27522	4293-4294	NNP	denotes	[
T27521	4286-4292	NN	denotes	factor
T27520	4267-4285	JJ	denotes	colony-stimulating
T27519	4256-4266	NN	denotes	macrophage
T27518	4244-4255	NN	denotes	granulocyte
T27517	4240-4243	CC	denotes	and
T27516	4238-4239	,	denotes	,
T27515	4234-4238	NNP	denotes	IL-1
T27514	4232-4233	,	denotes	,
T27513	4227-4232	NNP	denotes	TNF-α
T27512	4224-4226	IN	denotes	as
T27511	4219-4223	JJ	denotes	such
T27510	4211-4218	NNS	denotes	stimuli
T27509	4202-4210	NN	denotes	cytokine
T27508	4186-4201	JJ	denotes	proinflammatory
T27507	4183-4185	IN	denotes	of
T27506	4174-4182	NN	denotes	presence
T27505	4170-4173	DT	denotes	the
T27504	4167-4169	IN	denotes	in
T27503	4159-4166	NN	denotes	IL-10R1
T27502	4145-4158	JJ	denotes	intracellular
T27501	4142-4144	IN	denotes	of
T27500	4132-4141	NN	denotes	transport
T27499	4122-4131	VBN	denotes	decreased
T27498	4119-4121	TO	denotes	to
T27497	4115-4118	JJ	denotes	due
T27496	4109-4114	NNP	denotes	IL-10
T27602	4780-4782	IN	denotes	in
T27682	5169-5175	RB	denotes	mainly
T27683	5176-5178	TO	denotes	to
T27681	5165-5168	JJ	denotes	due
T27680	5163-5164	,	denotes	,
T27679	5161-5163	NNP	denotes	RA
T27678	5154-5160	JJ	denotes	active
T27677	5151-5153	IN	denotes	in
T27676	5142-5150	NN	denotes	response
T27675	5136-5141	NN	denotes	phase
T27674	5130-5135	JJ	denotes	acute
T27673	5126-5129	DT	denotes	the
T27672	5123-5125	IN	denotes	as
T27671	5118-5122	JJ	denotes	such
T27670	5109-5117	NN	denotes	reaction
T27669	5100-5108	JJ	denotes	systemic
T27668	5098-5099	DT	denotes	a
T27667	5088-5097	VBG	denotes	eliciting
T27666	5085-5087	IN	denotes	in
T27665	5080-5084	NN	denotes	role
T27664	5068-5079	JJ	denotes	predominant
T27663	5066-5067	DT	denotes	a
T27662	5060-5065	VBZ	denotes	plays
T27661	5055-5059	NN	denotes	IL-6
T27660	5053-5054	,	denotes	,
T27659	5044-5053	NNS	denotes	cytokines
T27658	5038-5043	DT	denotes	these
T27657	5035-5037	IN	denotes	Of
T27656	5033-5034	.	denotes	.
T27726	5406-5411	NNS	denotes	cells
T27725	5404-5405	NNP	denotes	T
T27724	5402-5403	CD	denotes	+
T27723	5399-5402	NNP	denotes	CD4
T27722	5392-5398	JJ	denotes	normal
T27721	5389-5391	IN	denotes	in
T27720	5378-5388	VBN	denotes	suppressed
T27719	5374-5377	VBD	denotes	was
T27718	5368-5373	NNP	denotes	IL-10
T27717	5365-5367	TO	denotes	to
T27716	5350-5364	NN	denotes	responsiveness
T27715	5346-5349	DT	denotes	the
T27714	5342-5345	CC	denotes	and
T27713	5340-5341	,	denotes	,
T27712	5332-5340	NNS	denotes	patients
T27711	5329-5331	NNP	denotes	RA
T27710	5322-5328	JJ	denotes	active
T27709	5319-5321	IN	denotes	of
T27708	5313-5318	NN	denotes	serum
T27707	5309-5312	DT	denotes	the
T27706	5306-5308	IN	denotes	in
T27705	5296-5305	VBN	denotes	contained
T27704	5289-5295	NN	denotes	factor
T27703	5272-5288	JJ	denotes	STAT3-activating
T27702	5266-5271	JJ	denotes	major
T27701	5262-5265	DT	denotes	the
T27700	5258-5261	VBD	denotes	was
T27699	5253-5257	NN	denotes	IL-6
T27698	5251-5252	,	denotes	,
T27697	5245-5251	NN	denotes	notion
T27696	5240-5244	DT	denotes	this
T27695	5235-5239	IN	denotes	with
T27694	5224-5234	JJ	denotes	Consistent
T27693	5222-5223	.	denotes	.
T27692	5221-5222	NNP	denotes	]
T27691	5219-5221	CD	denotes	27
T27690	5218-5219	NNP	denotes	[
T27689	5206-5217	NN	denotes	circulation
T27688	5200-5205	NN	denotes	blood
T27687	5196-5199	DT	denotes	the
T27686	5193-5195	IN	denotes	in
T27685	5183-5192	NN	denotes	abundance
T27684	5179-5182	PRP$	denotes	its
T27873	6170-6177	IN	denotes	because
T27872	6168-6169	,	denotes	,
T27871	6166-6168	NNP	denotes	ST
T27870	6157-6165	JJ	denotes	inflamed
T27869	6153-6156	DT	denotes	the
T27868	6148-6152	IN	denotes	into
T27867	6138-6147	NN	denotes	migration
T27866	6132-6137	IN	denotes	after
T27865	6122-6131	VBN	denotes	augmented
T27864	6117-6121	RB	denotes	even
T27863	6114-6116	VB	denotes	be
T27862	6110-6113	MD	denotes	can
T27861	6104-6109	NNP	denotes	IL-10
T27860	6101-6103	TO	denotes	to
T27859	6095-6100	NNS	denotes	cells
T27858	6093-6094	NNP	denotes	T
T27857	6091-6092	CD	denotes	+
T27856	6088-6091	CD	denotes	CD4
T27855	6085-6087	IN	denotes	of
T27854	6074-6084	NN	denotes	resistance
T27853	6070-6073	DT	denotes	the
T27852	6065-6069	IN	denotes	that
T27851	6056-6064	JJ	denotes	probable
T27850	6051-6055	RBS	denotes	most
T27849	6048-6050	VBZ	denotes	is
T27848	6045-6047	PRP	denotes	It
T27847	6043-6044	.	denotes	.
T27846	6036-6043	NN	denotes	pathway
T27845	6026-6035	VBG	denotes	signaling
T27844	6020-6025	CD	denotes	STAT3
T27843	6006-6019	JJ	denotes	IL-10-induced
T27842	6002-6005	DT	denotes	the
T27841	5999-6001	IN	denotes	in
T27840	5992-5998	NN	denotes	defect
T27839	5990-5991	DT	denotes	a
T27904	6353-6364	JJ	denotes	preliminary
T27903	6349-6352	PRP$	denotes	our
T27902	6346-6348	IN	denotes	by
T27901	6336-6345	VBN	denotes	suggested
T27900	6332-6335	VBD	denotes	was
T27899	6324-6331	NN	denotes	process
T27898	6319-6323	DT	denotes	this
T27897	6316-6318	IN	denotes	in
T27896	6306-6315	NNS	denotes	cytokines
T27895	6290-6305	JJ	denotes	proinflammatory
T27894	6280-6289	JJ	denotes	essential
T27893	6274-6279	JJ	denotes	other
T27892	6271-6273	IN	denotes	of
T27891	6259-6270	NN	denotes	involvement
T27890	6255-6258	DT	denotes	the
T27889	6253-6254	,	denotes	,
T27888	6245-6253	NN	denotes	addition
T27887	6242-6244	IN	denotes	In
T27886	6240-6241	.	denotes	.
T27885	6239-6240	NNP	denotes	]
T27884	6237-6239	CD	denotes	27
T27883	6236-6237	NNP	denotes	[
T27882	6230-6235	NN	denotes	level
T27881	6224-6229	NN	denotes	blood
T27880	6220-6223	DT	denotes	the
T27879	6215-6219	IN	denotes	with
T27878	6206-6214	VBN	denotes	compared
T27877	6193-6205	VBN	denotes	concentrated
T27876	6186-6192	RB	denotes	highly
T27875	6183-6185	VBZ	denotes	is
T27874	6178-6182	NNP	denotes	IL-6
T27968	6733-6734	NNP	denotes	]
T27967	6728-6733	CD	denotes	34,35
T27966	6727-6728	NNP	denotes	[
T27965	6717-6726	NNS	denotes	cytokines
T27964	6712-6716	DT	denotes	both
T27963	6704-6711	VB	denotes	produce
T27962	6692-6703	VBZ	denotes	infiltrates
T27961	6685-6691	NNP	denotes	T-cell
T27960	6677-6684	IN	denotes	because
T27959	6675-6676	,	denotes	,
T27958	6673-6675	NNP	denotes	ST
T27957	6669-6672	DT	denotes	the
T27956	6666-6668	IN	denotes	in
T27955	6656-6665	VBG	denotes	signaling
T27954	6650-6655	NNP	denotes	IL-10
T27953	6641-6649	VBN	denotes	impaired
T27952	6637-6640	IN	denotes	for
T27951	6625-6636	JJ	denotes	responsible
T27950	6622-6624	VB	denotes	be
T27949	6616-6621	MD	denotes	could
T27948	6605-6615	PRP	denotes	themselves
T27947	6599-6604	NNS	denotes	cells
T27946	6597-6598	NNP	denotes	T
T27945	6595-6596	NNP	denotes	+
T27944	6592-6595	NNP	denotes	CD4
T27943	6589-6591	IN	denotes	by
T28161	7816-7818	CD	denotes	38
T28160	7815-7816	NNP	denotes	[
T28159	7803-7814	NNS	denotes	fibroblasts
T28158	7794-7802	JJ	denotes	synovial
T28157	7777-7793	JJ	denotes	factor-dependent
T28156	7770-7776	NN	denotes	growth
T28155	7767-7769	IN	denotes	of
T28154	7757-7766	NN	denotes	expansion
T28153	7753-7756	CC	denotes	and
T28152	7744-7752	NN	denotes	survival
T28151	7740-7743	DT	denotes	the
T28150	7737-7739	IN	denotes	in
T28149	7728-7736	JJ	denotes	critical
T28148	7725-7727	VBZ	denotes	is
T28147	7719-7724	NNP	denotes	STAT3
T28146	7717-7718	,	denotes	,
T28145	7711-7717	NN	denotes	regard
T28144	7706-7710	DT	denotes	this
T28143	7703-7705	IN	denotes	In
T28142	7701-7702	.	denotes	.
T28141	7700-7701	NNP	denotes	]
T28176	7924-7927	VBZ	denotes	has
T28175	7914-7923	NN	denotes	arthritis
T28174	7903-7913	JJ	denotes	autoimmune
T28173	7884-7902	JJ	denotes	Th1-cell-dominated
T28172	7881-7883	IN	denotes	in
T28171	7871-7880	VBG	denotes	signaling
T28170	7865-7870	CD	denotes	STAT3
T28169	7854-7864	JJ	denotes	persistent
T28168	7851-7853	IN	denotes	of
T28167	7838-7850	NN	denotes	significance
T28166	7834-7837	DT	denotes	the
T28165	7832-7833	,	denotes	,
T28164	7821-7832	RB	denotes	Furthermore
T28163	7819-7820	.	denotes	.
T28162	7818-7819	NNP	denotes	]
T28662	10102-10104	IN	denotes	of
T28661	10093-10101	NN	denotes	presence
T28660	10089-10092	DT	denotes	the
T28659	10086-10088	IN	denotes	in
T28658	10080-10085	NNP	denotes	IFN-γ
T28657	10077-10079	IN	denotes	of
T28656	10070-10076	NNS	denotes	levels
T28655	10065-10069	JJ	denotes	high
T28664	10110-10111	,	denotes	,
T28663	10105-10110	NNP	denotes	IL-10
T28913	10198-10200	IN	denotes	in
T28912	10189-10197	NN	denotes	interest
T28911	10186-10188	IN	denotes	of
T28910	10183-10185	VBZ	denotes	is
T28909	10180-10182	PRP	denotes	It
T28908	10178-10179	.	denotes	.
T28907	10177-10178	NNP	denotes	]
T28906	10175-10177	CD	denotes	32
T28905	10174-10175	NNP	denotes	[
T28904	10168-10173	CD	denotes	SOCS1
T28903	10165-10167	IN	denotes	of
T28902	10157-10164	NN	denotes	inducer
T28901	10150-10156	JJ	denotes	potent
T28900	10148-10149	DT	denotes	a
T28899	10145-10147	IN	denotes	as
T28898	10139-10144	VBN	denotes	known
T28897	10134-10138	VBN	denotes	been
T28896	10130-10133	VBZ	denotes	has
T28895	10124-10129	NNP	denotes	IFN-γ
T28894	10116-10123	IN	denotes	because
T28893	10112-10115	CC	denotes	and
T28914	10201-10205	DT	denotes	this
T29190	10278-10280	IN	denotes	of
T29189	10271-10277	NNS	denotes	levels
T29188	10266-10270	JJ	denotes	high
T29187	10258-10265	VBP	denotes	express
T29186	10252-10257	NNS	denotes	cells
T29185	10248-10251	NNP	denotes	Th2
T29184	10244-10247	CC	denotes	and
T29183	10240-10243	NNP	denotes	Th1
T29182	10230-10239	VBN	denotes	polarized
T29181	10225-10229	DT	denotes	that
T29180	10216-10224	VB	denotes	indicate
T29179	10213-10215	TO	denotes	to
T29178	10206-10212	NN	denotes	regard
T29261	10704-10705	,	denotes	,
T29260	10698-10704	NN	denotes	notion
T29259	10693-10697	DT	denotes	this
T29258	10688-10692	IN	denotes	with
T29257	10677-10687	JJ	denotes	Consistent
T29256	10675-10676	.	denotes	.
T29255	10663-10675	RB	denotes	respectively
T29254	10661-10662	,	denotes	,
T29253	10653-10661	NNS	denotes	pathways
T29252	10643-10652	VBG	denotes	signaling
T29251	10637-10642	CD	denotes	STAT4
T29250	10631-10636	NN	denotes	IL-12
T29249	10627-10630	DT	denotes	the
T29248	10623-10626	CC	denotes	and
T29247	10617-10622	CD	denotes	STAT6
T29246	10612-10616	NN	denotes	IL-4
T29245	10608-10611	DT	denotes	the
T29244	10605-10607	IN	denotes	of
T29243	10594-10604	NNS	denotes	repressors
T29242	10583-10593	JJ	denotes	cross-talk
T29241	10581-10582	,	denotes	,
T29240	10572-10581	JJ	denotes	exclusive
T29239	10563-10571	RB	denotes	mutually
T29238	10561-10562	,	denotes	,
T29237	10549-10561	JJ	denotes	Th2-specific
T29236	10545-10548	CC	denotes	and
T29235	10532-10544	JJ	denotes	Th1-specific
T29234	10529-10531	IN	denotes	as
T29233	10523-10528	NNS	denotes	roles
R13597	T26799	T26803	nsubj	CD4,orchestrate
R13599	T26800	T26802	nummod	+,cells
R13601	T26801	T26802	compound	T,cells
R13603	T26802	T26803	nsubj	cells,orchestrate
R13605	T26803	T26803	ROOT	orchestrate,orchestrate
R13606	T26804	T26808	det	the,response
R13608	T26805	T26808	amod	Th1-type,response
R13610	T26806	T26808	amod	cell-mediated,response
R13611	T26807	T26808	amod	immune,response
R13612	T26808	T26803	dobj	response,orchestrate
R13613	T26809	T26808	prep	in,response
R13614	T26810	T26811	compound	RA,[
R13615	T26811	T26809	pobj	[,in
R13616	T26877	T26879	det	the,ligands
R13617	T26878	T26879	compound	CD28,ligands
R13618	T26879	T26895	nsubjpass	ligands,expressed
R13619	T26880	T26879	punct	",",ligands
R13620	T26812	T26813	nummod	22,]
R13621	T26881	T26882	det	both,CD80
R13622	T26882	T26879	conj	CD80,ligands
R13623	T26883	T26882	cc	and,CD80
R13624	T26813	T26811	appos	],[
R13625	T26884	T26882	conj	CD86,CD80
R13626	T26885	T26879	punct	",",ligands
R13627	T26814	T26803	punct	.,orchestrate
R13628	T26815	T26819	amod	Activated,cells
R13629	T26886	T26887	advmod	together,with
R13630	T26816	T26819	compound	CD4,cells
R13631	T26887	T26879	prep	with,ligands
R13632	T26817	T26819	nummod	+,cells
R13633	T26888	T26891	compound	MHC,antigens
R13634	T26889	T26891	compound	class,antigens
R13635	T26890	T26891	compound	II,antigens
R13636	T26818	T26819	compound	T,cells
R13637	T26891	T26887	pobj	antigens,with
R13638	T26892	T26895	punct	",",expressed
R13639	T26893	T26895	auxpass	are,expressed
R13640	T26819	T26820	nsubj	cells,stimulate
R13641	T26894	T26895	advmod	substantially,expressed
R13642	T26895	T26895	ROOT	expressed,expressed
R13643	T26820	T26820	ROOT	stimulate,stimulate
R13644	T26821	T26820	dobj	macrophages,stimulate
R13645	T26896	T26895	agent	by,expressed
R13646	T26822	T26821	punct	",",macrophages
R13647	T26897	T26898	amod	antigen-presenting,cells
R13648	T26898	T26896	pobj	cells,by
R13649	T26899	T26900	amod	such,as
R13650	T26823	T26824	amod	synovial,fibroblasts
R13651	T26900	T26898	prep	as,cells
R13652	T26901	T26900	pobj	macrophages,as
R13653	T26824	T26821	conj	fibroblasts,macrophages
R13654	T26902	T26901	cc	and,macrophages
R13655	T26903	T26904	amod	dendritic,cells
R13656	T26904	T26901	conj	cells,macrophages
R13657	T26905	T26907	nmod	[,]
R13658	T26825	T26824	punct	",",fibroblasts
R13659	T26906	T26907	nummod	18-20,]
R13660	T26907	T26901	conj	],macrophages
R13661	T26908	T26895	punct	.,expressed
R13662	T26826	T26827	compound	B,cells
R13663	T26909	T26910	det	The,significance
R13664	T26910	T26922	nsubjpass	significance,proven
R13665	T26911	T26910	prep	of,significance
R13666	T26827	T26824	conj	cells,fibroblasts
R13667	T26912	T26913	nummod	CD28,engagement
R13668	T26913	T26911	pobj	engagement,of
R13669	T26914	T26913	prep	in,engagement
R13670	T26915	T26918	det	the,process
R13671	T26916	T26918	amod	T-cell-mediated,process
R13672	T26917	T26918	compound	disease,process
R13673	T26828	T26827	punct	",",cells
R13674	T26918	T26914	pobj	process,in
R13675	T26919	T26922	aux	has,proven
R13676	T26920	T26922	advmod	recently,proven
R13677	T26921	T26922	auxpass	been,proven
R13678	T26829	T26827	cc	and,cells
R13679	T26922	T26922	ROOT	proven,proven
R13680	T26923	T26922	agent	by,proven
R13681	T26924	T26926	det	the,efficacy
R13682	T26830	T26827	conj	osteoclasts,cells
R13683	T26925	T26926	amod	clinical,efficacy
R13684	T26926	T26923	pobj	efficacy,by
R13685	T26831	T26820	prep	through,stimulate
R13686	T26927	T26926	prep	of,efficacy
R13687	T26928	T26932	poss	its,antigen
R13688	T26929	T26932	nmod	blocker,antigen
R13689	T26832	T26833	det	the,expression
R13690	T26930	T26932	nmod	cytotoxic,antigen
R13691	T26931	T26932	amod	T-cell-associated,antigen
R13692	T26932	T26927	pobj	antigen,of
R13693	T26833	T26831	pobj	expression,through
R13694	T26933	T26932	nummod	4,antigen
R13695	T26934	T26932	punct	(,antigen
R13696	T26834	T26833	prep	of,expression
R13697	T26935	T26932	appos	CD152,antigen
R13698	T26936	T26932	punct	),antigen
R13699	T26937	T26938	punct	-,IgG
R13700	T26835	T26836	compound	cell,surface
R13701	T26836	T26837	compound	surface,molecules
R13702	T26938	T26926	appos	IgG,efficacy
R13703	T26939	T26938	prep	in,IgG
R13704	T26940	T26941	compound	RA,patients
R13705	T26837	T26834	pobj	molecules,of
R13706	T26941	T26939	pobj	patients,in
R13707	T26942	T26944	nmod	[,]
R13708	T26838	T26837	cc	and,molecules
R13709	T26943	T26944	nummod	23,]
R13710	T26944	T26938	conj	],IgG
R13711	T26945	T26922	punct	.,proven
R13712	T26839	T26840	amod	Th1,cytokines
R13713	T26946	T26947	nsubj	IL-10,plays
R13714	T26947	T26947	ROOT	plays,plays
R13715	T26840	T26837	conj	cytokines,molecules
R13716	T26948	T26950	det	a,role
R13717	T26949	T26950	amod	predominant,role
R13718	T26950	T26947	dobj	role,plays
R13719	T26951	T26950	prep	in,role
R13720	T26952	T26951	pcomp	limiting,in
R13721	T26953	T26956	amod	immune,responses
R13722	T26841	T26820	punct	",",stimulate
R13723	T26954	T26953	cc	and,immune
R13724	T26955	T26953	conj	inflammatory,immune
R13725	T26956	T26952	dobj	responses,limiting
R13726	T26842	T26843	advmod	thereby,contributing
R13727	T26957	T26952	prep	by,limiting
R13728	T26958	T26957	pcomp	regulating,by
R13729	T26959	T26960	det	the,function
R13730	T26843	T26820	advcl	contributing,stimulate
R13731	T26960	T26958	dobj	function,regulating
R13732	T26961	T26960	prep	of,function
R13733	T26962	T26963	det	both,macrophages
R13734	T26844	T26843	prep	to,contributing
R13735	T26963	T26961	pobj	macrophages,of
R13736	T26964	T26963	cc	and,macrophages
R13737	T26965	T26966	amod	Th1,cells
R13738	T26845	T26848	preconj	both,inflammation
R13739	T26966	T26963	conj	cells,macrophages
R13740	T26967	T26947	conj	[,plays
R13741	T26968	T26969	nummod	1,]
R13742	T26846	T26848	det	the,inflammation
R13743	T26969	T26967	dobj	],[
R13744	T26970	T26947	punct	.,plays
R13745	T26971	T26972	nsubj	IL-10,inhibits
R13746	T26847	T26848	amod	chronic,inflammation
R13747	T26972	T26972	ROOT	inhibits,inhibits
R13748	T26848	T26844	pobj	inflammation,to
R13749	T26849	T26848	cc	and,inflammation
R13750	T26973	T26975	det	the,phosphorylation
R13751	T26850	T26852	det	the,destruction
R13752	T26974	T26975	compound	tyrosine,phosphorylation
R13753	T26975	T26972	dobj	phosphorylation,inhibits
R13754	T26976	T26975	prep	of,phosphorylation
R13755	T26851	T26852	amod	joint,destruction
R13756	T26977	T26979	det	the,molecule
R13757	T26978	T26979	compound	CD28,molecule
R13758	T26979	T26976	pobj	molecule,of
R13759	T26852	T26848	conj	destruction,inflammation
R13760	T26980	T26975	cc	and,phosphorylation
R13761	T26981	T26985	det	the,binding
R13762	T26982	T26985	amod	subsequent,binding
R13763	T26853	T26820	punct	.,stimulate
R13764	T26983	T26985	advmod	phosphatidylinositol,binding
R13765	T26984	T26985	advmod	3-kinase,binding
R13766	T26985	T26975	conj	binding,phosphorylation
R13767	T26854	T26858	nsubj	CD4,require
R13768	T26986	T26985	prep	in,binding
R13769	T26987	T26988	compound	T,cells
R13770	T26988	T26986	pobj	cells,in
R13771	T26989	T26985	punct	",",binding
R13772	T26990	T26985	cc	and,binding
R13773	T26991	T26993	advmod	thereby,acts
R13774	T26855	T26857	nummod	+,cells
R13775	T26856	T26857	compound	T,cells
R13776	T26857	T26858	nsubj	cells,require
R13777	T26858	T26858	ROOT	require,require
R13778	T26992	T26993	advmod	directly,acts
R13779	T26993	T26972	conj	acts,inhibits
R13780	T26994	T26993	prep	on,acts
R13781	T26859	T26860	nummod	two,signals
R13782	T26995	T26996	compound	T,cells
R13783	T26996	T26994	pobj	cells,on
R13784	T26860	T26858	dobj	signals,require
R13785	T26997	T26999	nmod	[,]
R13786	T26998	T26999	nummod	24,]
R13787	T26999	T26996	appos	],cells
R13788	T27000	T26972	punct	.,inhibits
R13789	T26861	T26863	aux	to,activated
R13790	T27001	T27007	prep	In,found
R13791	T27002	T27004	det	the,study
R13792	T26862	T26863	auxpass	be,activated
R13793	T27003	T27004	amod	present,study
R13794	T27004	T27001	pobj	study,In
R13795	T27005	T27007	punct	",",found
R13796	T26863	T26860	relcl	activated,signals
R13797	T27006	T27007	nsubj	we,found
R13798	T27007	T27007	ROOT	found,found
R13799	T27008	T27011	mark	that,+
R13800	T26864	T26860	punct	;,signals
R13801	T27009	T27010	compound	PB,CD4
R13802	T27010	T27011	nsubj	CD4,+
R13803	T26865	T26867	compound	antigen,occupancy
R13804	T27011	T27026	advcl	+,are
R13805	T27012	T27013	compound	T,cells
R13806	T27013	T27011	dobj	cells,+
R13807	T27014	T27011	prep	from,+
R13808	T26866	T26867	compound	receptor,occupancy
R13809	T27015	T27014	pobj	patients,from
R13810	T27016	T27015	prep	with,patients
R13811	T26867	T26860	appos	occupancy,signals
R13812	T26868	T26867	cc	and,occupancy
R13813	T27017	T27018	amod	active,RA
R13814	T27018	T27016	pobj	RA,with
R13815	T26869	T26870	amod	CD28-mediated,costimulation
R13816	T27019	T27026	punct	",",are
R13817	T27020	T27026	prep	in,are
R13818	T27021	T27022	det	the,presence
R13819	T27022	T27020	pobj	presence,in
R13820	T27023	T27022	prep	of,presence
R13821	T27024	T27023	pobj	IL-10,of
R13822	T26870	T26867	conj	costimulation,occupancy
R13823	T27025	T27026	punct	",",are
R13824	T27026	T27007	ccomp	are,found
R13825	T26871	T26858	punct	.,require
R13826	T27027	T27026	acomp	able,are
R13827	T27028	T27029	aux	to,produce
R13828	T27029	T27027	xcomp	produce,able
R13829	T27030	T27031	amod	higher,levels
R13830	T26872	T26895	prep	In,expressed
R13831	T27031	T27029	dobj	levels,produce
R13832	T27032	T27031	prep	of,levels
R13833	T27033	T27032	pobj	IFN-γ,of
R13834	T26873	T26875	det	the,lesion
R13835	T27034	T27029	prep	after,produce
R13836	T27035	T27034	pobj	CD3,after
R13837	T26874	T26875	compound	ST,lesion
R13838	T27036	T27035	cc	and,CD3
R13839	T27037	T27038	compound	CD28,costimulation
R13840	T27038	T27035	conj	costimulation,CD3
R13841	T26875	T26872	pobj	lesion,In
R13842	T27039	T27038	prep	than,costimulation
R13843	T27040	T27044	amod	normal,cells
R13844	T26876	T26895	punct	",",expressed
R13845	T27041	T27044	compound	CD4,cells
R13846	T27042	T27044	nummod	+,cells
R13847	T27043	T27044	compound	T,cells
R13848	T27044	T27039	pobj	cells,than
R13849	T27073	T27076	compound	CD4,cells
R13850	T27045	T27007	punct	.,found
R13851	T27046	T27061	prep	Despite,suppressed
R13852	T27047	T27049	amod	high-level,expression
R13853	T27074	T27076	nummod	+,cells
R13854	T27048	T27049	compound	IL-10R1,expression
R13855	T27049	T27046	pobj	expression,Despite
R13856	T27050	T27049	cc	and,expression
R13857	T27075	T27076	compound	T,cells
R13858	T27051	T27053	amod	constitutive,activation
R13859	T27052	T27053	nummod	STAT3,activation
R13860	T27053	T27049	conj	activation,expression
R13861	T27076	T27071	pobj	cells,to
R13862	T27054	T27053	punct	",",activation
R13863	T27055	T27057	nmod	IL-10-induced,phosphorylation
R13864	T27056	T27057	compound	tyrosine,phosphorylation
R13865	T27077	T27076	punct	",",cells
R13866	T27057	T27053	conj	phosphorylation,activation
R13867	T27058	T27057	prep	of,phosphorylation
R13868	T27059	T27058	pobj	STAT3,of
R13869	T27060	T27061	auxpass	is,suppressed
R13870	T27061	T27061	ROOT	suppressed,suppressed
R13871	T27062	T27061	prep	in,suppressed
R13872	T27063	T27064	compound	RA,CD4
R13873	T27078	T27081	advmod	where,is
R13874	T27064	T27062	pobj	CD4,in
R13875	T27065	T27067	amod	+,cells
R13876	T27066	T27067	compound	T,cells
R13877	T27079	T27080	compound	STAT3,phosphorylation
R13878	T27067	T27061	dobj	cells,suppressed
R13879	T27068	T27061	punct	",",suppressed
R13880	T27069	T27061	prep	in,suppressed
R13881	T27080	T27081	nsubj	phosphorylation,is
R13882	T27070	T27069	pobj	contrast,in
R13883	T27071	T27070	prep	to,contrast
R13884	T27072	T27076	amod	normal,cells
R13885	T27081	T27076	relcl	is,cells
R13886	T27082	T27083	advmod	dose-dependently,inducible
R13887	T27083	T27081	acomp	inducible,is
R13888	T27084	T27083	prep	by,inducible
R13889	T27088	T27092	nsubj	IL-6,induces
R13890	T27089	T27088	prep	from,IL-6
R13891	T27085	T27084	pobj	IL-10,by
R13892	T27090	T27091	compound	RA,patients
R13893	T27091	T27089	pobj	patients,from
R13894	T27092	T27092	ROOT	induces,induces
R13895	T27086	T27061	punct	.,suppressed
R13896	T27093	T27092	dobj	STAT3,induces
R13897	T27094	T27093	cc	but,STAT3
R13898	T27095	T27097	neg	not,phosphorylation
R13899	T27087	T27088	compound	Serum,IL-6
R13936	T27192	T27199	nsubj	inhibition,is
R13940	T27193	T27192	prep	of,inhibition
R13944	T27194	T27198	compound	CD4,production
R13948	T27195	T27198	compound	+,production
R13952	T27196	T27198	compound	T-cell,production
R13953	T27197	T27198	compound	cytokine,production
R13954	T27134	T27132	pobj	transcripts,of
R13955	T27135	T27129	prep	in,contain
R13956	T27198	T27193	pobj	production,of
R13957	T27136	T27135	pobj	comparison,in
R13958	T27137	T27136	prep	with,comparison
R13959	T27138	T27142	amod	normal,cells
R13960	T27199	T27199	ROOT	is,is
R13961	T27139	T27142	compound	CD4,cells
R13962	T27140	T27142	nummod	+,cells
R13963	T27200	T27201	advmod	principally,dependent
R13964	T27141	T27142	compound	T,cells
R13965	T27142	T27137	pobj	cells,with
R13966	T27143	T27123	punct	.,contain
R13967	T27201	T27199	acomp	dependent,is
R13968	T27144	T27145	det	These,findings
R13969	T27145	T27146	nsubj	findings,indicate
R13970	T27146	T27146	ROOT	indicate,indicate
R13971	T27147	T27152	mark	that,become
R13972	T27148	T27152	nsubj	CD4,become
R13973	T27202	T27201	prep	on,dependent
R13974	T27149	T27151	nummod	+,cells
R13975	T27150	T27151	compound	T,cells
R13976	T27151	T27152	nsubj	cells,become
R13977	T27152	T27146	ccomp	become,indicate
R13979	T27153	T27152	acomp	resistant,become
R13980	T27154	T27153	prep	to,resistant
R13981	T27155	T27157	det	the,effect
R13983	T27156	T27157	amod	inhibitory,effect
R13984	T27157	T27154	pobj	effect,to
R13985	T27158	T27157	prep	of,effect
R13987	T27159	T27158	pobj	IL-10,of
R13988	T27160	T27152	prep	before,become
R13989	T27161	T27160	pobj	migration,before
R13991	T27162	T27161	prep	into,migration
R13992	T27163	T27165	det	the,ST
R13993	T27164	T27165	amod	inflamed,ST
R13995	T27165	T27162	pobj	ST,into
R13996	T27166	T27152	punct	",",become
R13997	T27167	T27152	cc	and,become
R13999	T27168	T27152	conj	suggest,become
R14000	T27169	T27173	mark	that,be
R14002	T27170	T27171	det	this,resistance
R14003	T27171	T27173	nsubj	resistance,be
R14004	T27172	T27173	aux	may,be
R14005	T27173	T27168	ccomp	be,suggest
R14007	T27174	T27173	acomp	attributable,be
R14008	T27175	T27174	prep	to,attributable
R14009	T27176	T27179	amod	impaired,activation
R14011	T27177	T27179	amod	IL-10-dependent,activation
R14012	T27178	T27179	nummod	STAT3,activation
R14014	T27179	T27175	pobj	activation,to
R14015	T27180	T27173	punct	",",be
R14016	T27181	T27173	prep	in,be
R14020	T27280	T27265	punct	.,shown
R14021	T27281	T27283	det	This,effect
R14022	T27282	T27283	amod	direct,effect
R14024	T27283	T27287	nsubjpass	effect,limited
R14025	T27284	T27287	advmod	also,limited
R14027	T27285	T27287	aux	may,limited
R14028	T27286	T27287	auxpass	be,limited
R14029	T27287	T27287	ROOT	limited,limited
R14030	T27288	T27287	prep	in,limited
R14032	T27289	T27291	amod	active,patients
R14033	T27290	T27291	compound	RA,patients
R14035	T27291	T27288	pobj	patients,in
R14039	T27292	T27287	punct	",",limited
R14040	T27223	T27224	auxpass	be,restricted
R14041	T27293	T27300	mark	because,showed
R14042	T27294	T27296	poss	their,CD4
R14043	T27295	T27296	compound	PB,CD4
R14044	T27224	T27221	xcomp	restricted,thought
R14045	T27296	T27299	nmod	CD4,cells
R14046	T27297	T27299	amod	+,cells
R14047	T27225	T27224	prep	at,restricted
R14048	T27298	T27299	compound	T,cells
R14049	T27299	T27300	nsubj	cells,showed
R14050	T27300	T27287	advcl	showed,limited
R14051	T27226	T27227	det	the,site
R14052	T27227	T27225	pobj	site,at
R14053	T27228	T27227	prep	of,site
R14054	T27301	T27304	det	a,inhibition
R14055	T27302	T27304	amod	defective,inhibition
R14056	T27229	T27230	compound	T-cell,activation
R14057	T27303	T27304	compound	IL-10,inhibition
R14058	T27304	T27300	dobj	inhibition,showed
R14059	T27305	T27304	prep	of,inhibition
R14060	T27230	T27228	pobj	activation,of
R14061	T27306	T27307	amod	CD28-costimulated,production
R14062	T27307	T27305	pobj	production,of
R14063	T27231	T27230	prep	in,activation
R14064	T27308	T27307	prep	of,production
R14065	T27309	T27310	preconj	both,IFN-γ
R14066	T27310	T27308	pobj	IFN-γ,of
R14067	T27232	T27231	pobj	RA,in
R14068	T27311	T27310	cc	and,IFN-γ
R14069	T27312	T27310	conj	IL-2,IFN-γ
R14070	T27313	T27287	punct	.,limited
R14071	T27314	T27315	amod	Numerous,cytokines
R14072	T27315	T27324	nsubj	cytokines,detected
R14073	T27233	T27221	punct	",",thought
R14074	T27316	T27315	punct	",",cytokines
R14075	T27317	T27318	preconj	both,proinflammatory
R14076	T27318	T27315	conj	proinflammatory,cytokines
R14077	T27319	T27318	cc	and,proinflammatory
R14078	T27234	T27239	mark	because,express
R14079	T27320	T27318	conj	anti-inflammatory,proinflammatory
R14080	T27321	T27324	punct	",",detected
R14081	T27235	T27239	nsubj	macrophages,express
R14082	T27322	T27324	aux	have,detected
R14083	T27323	T27324	auxpass	been,detected
R14084	T27324	T27324	ROOT	detected,detected
R14085	T27236	T27235	prep	in,macrophages
R14086	T27325	T27324	prep	in,detected
R14087	T27326	T27327	det	the,ST
R14088	T27237	T27238	det	the,ST
R14089	T27327	T27325	pobj	ST,in
R14090	T27328	T27327	prep	of,ST
R14091	T27329	T27328	pobj	RA,of
R14092	T27238	T27236	pobj	ST,in
R14093	T27330	T27324	punct	",",detected
R14094	T27331	T27324	cc	and,detected
R14095	T27239	T27221	advcl	express,thought
R14096	T27332	T27333	det	the,balance
R14097	T27333	T27339	nsubj	balance,regulates
R14098	T27240	T27241	amod	high,levels
R14099	T27334	T27333	prep	between,balance
R14100	T27335	T27338	det	these,activities
R14101	T27336	T27338	amod	opposing,activities
R14102	T27241	T27239	dobj	levels,express
R14103	T27337	T27338	compound	cytokine,activities
R14104	T27338	T27334	pobj	activities,between
R14105	T27339	T27324	conj	regulates,detected
R14106	T27242	T27241	prep	of,levels
R14107	T27340	T27341	compound	disease,severity
R14108	T27341	T27339	dobj	severity,regulates
R14109	T27342	T27344	nmod	[,]
R14110	T27243	T27242	pobj	cytokines,of
R14111	T27343	T27344	nummod	10,]
R14112	T27344	T27339	dobj	],regulates
R14113	T27244	T27243	punct	",",cytokines
R14114	T27345	T27339	punct	.,regulates
R14115	T27346	T27347	compound	Endogenous,IL-10
R14116	T27347	T27349	nsubj	IL-10,produced
R14117	T27245	T27243	conj	CD80,cytokines
R14118	T27348	T27349	punct	",",produced
R14119	T27349	T27349	ROOT	produced,produced
R14120	T27246	T27245	cc	and,CD80
R14121	T27350	T27351	advmod	mainly,by
R14122	T27351	T27349	prep	by,produced
R14123	T27352	T27351	pobj	macrophages,by
R14124	T27353	T27352	cc	and,macrophages
R14125	T27354	T27355	compound	T,cells
R14126	T27355	T27352	conj	cells,macrophages
R14127	T27356	T27357	punct	",",inhibits
R14128	T27247	T27245	conj	CD86,CD80
R14129	T27357	T27349	parataxis	inhibits,produced
R14130	T27358	T27360	amod	proinflammatory,production
R14131	T27359	T27360	compound	cytokine,production
R14132	T27248	T27245	conj	molecules,CD80
R14133	T27360	T27357	dobj	production,inhibits
R14134	T27249	T27248	punct	",",molecules
R14135	T27250	T27248	cc	and,molecules
R14136	T27361	T27360	prep	by,production
R14137	T27362	T27363	compound	ST,cells
R14138	T27251	T27253	compound	MHC,II
R14139	T27363	T27361	pobj	cells,by
R14140	T27364	T27366	nmod	[,]
R14141	T27365	T27366	nummod	12,]
R14142	T27366	T27357	dobj	],inhibits
R14143	T27252	T27253	compound	class,II
R14144	T27367	T27357	punct	.,inhibits
R14145	T27368	T27373	advmod	However,seems
R14146	T27253	T27254	nsubj	II,antigens
R14147	T27369	T27373	punct	",",seems
R14148	T27370	T27372	det	this,activity
R14149	T27371	T27372	amod	regulatory,activity
R14150	T27254	T27248	conj	antigens,molecules
R14151	T27372	T27373	nsubj	activity,seems
R14152	T27373	T27373	ROOT	seems,seems
R14153	T27255	T27257	compound	[,]
R14154	T27374	T27376	aux	to,restricted
R14155	T27375	T27376	auxpass	be,restricted
R14156	T27256	T27257	compound	"10,18-20",]
R14157	T27257	T27254	dobj	],antigens
R14158	T27376	T27373	xcomp	restricted,seems
R14159	T27377	T27376	prep	during,restricted
R14160	T27258	T27254	punct	.,antigens
R14161	T27378	T27379	amod	chronic,inflammation
R14162	T27379	T27377	pobj	inflammation,during
R14163	T27259	T27260	advmod	More,recently
R14164	T27260	T27265	advmod	recently,shown
R14167	T27261	T27265	punct	",",shown
R14170	T27262	T27265	nsubjpass	IL-10,shown
R14176	T27263	T27265	aux	has,shown
R14180	T27264	T27265	auxpass	been,shown
R14184	T27265	T27265	ROOT	shown,shown
R14186	T27266	T27267	aux	to,induce
R14187	T27267	T27265	xcomp	induce,shown
R14188	T27268	T27271	det	the,unresponsiveness
R14191	T27269	T27271	amod	antigen-specific,unresponsiveness
R14195	T27270	T27271	compound	T-cell,unresponsiveness
R14199	T27271	T27267	dobj	unresponsiveness,induce
R14202	T27272	T27267	prep	by,induce
R14206	T27273	T27272	pcomp	inhibiting,by
R14207	T27274	T27276	nmod	CD28,phosphorylation
R14208	T27409	T27408	cc	and,IL-10
R14209	T27275	T27276	compound	tyrosine,phosphorylation
R14210	T27410	T27408	conj	IL-6,IL-10
R14211	T27411	T27406	prep	in,shared
R14212	T27412	T27413	amod	adhered,macrophages
R14213	T27276	T27277	compound	phosphorylation,[
R14214	T27413	T27411	pobj	macrophages,in
R14215	T27414	T27411	pobj	[,in
R14216	T27415	T27416	nummod	13,]
R14217	T27416	T27414	appos	],[
R14218	T27277	T27273	dobj	[,inhibiting
R14219	T27417	T27400	punct	.,inhibits
R14220	T27418	T27419	advmod	More,importantly
R14221	T27278	T27279	nummod	33,]
R14222	T27419	T27424	advmod	importantly,is
R14223	T27420	T27424	punct	",",is
R14224	T27421	T27423	amod	IL-10-mediated,activation
R14225	T27422	T27423	nummod	STAT3,activation
R14226	T27423	T27424	nsubj	activation,is
R14227	T27424	T27424	ROOT	is,is
R14228	T27279	T27277	appos	],[
R14229	T27425	T27426	advmod	mostly,undetectable
R14230	T27426	T27424	acomp	undetectable,is
R14231	T27427	T27426	prep	in,undetectable
R14232	T27428	T27427	pobj	RA,in
R14234	T27429	T27430	amod	synovial,macrophages
R14235	T27430	T27424	attr	macrophages,is
R14237	T27431	T27424	punct	.,is
R14238	T27432	T27434	det	This,IL-10
R14239	T27433	T27434	amod	impaired,IL-10
R14241	T27434	T27438	nsubjpass	IL-10,induced
R14242	T27435	T27438	nsubjpass	signaling,induced
R14243	T27436	T27438	auxpass	is,induced
R14245	T27437	T27438	advmod	probably,induced
R14246	T27438	T27438	ROOT	induced,induced
R14247	T27439	T27438	agent	by,induced
R14249	T27440	T27441	amod	chronic,exposure
R14250	T27441	T27439	pobj	exposure,by
R14251	T27442	T27441	prep	to,exposure
R14253	T27443	T27444	amod	immune,complexes
R14254	T27444	T27442	pobj	complexes,to
R14256	T27445	T27444	prep	in,complexes
R14257	T27446	T27445	pobj	vivo,in
R14258	T27447	T27438	punct	",",induced
R14259	T27448	T27459	mark	because,suppressed
R14261	T27449	T27453	preconj	both,expression
R14262	T27450	T27451	compound	cell,surface
R14263	T27480	T27438	punct	.,induced
R14264	T27481	T27489	advmod	Furthermore,are
R14267	T27482	T27489	punct	",",are
R14271	T27483	T27484	amod	dendritic,cells
R14272	T27456	T27457	amod	Jak1,activation
R14273	T27457	T27453	conj	activation,expression
R14274	T27458	T27459	auxpass	are,suppressed
R14275	T27484	T27489	nsubj	cells,are
R14276	T27459	T27438	advcl	suppressed,induced
R14277	T27460	T27459	prep	in,suppressed
R14278	T27461	T27462	amod	IFN-γ-primed,macrophages
R14279	T27485	T27484	prep	from,cells
R14280	T27462	T27460	pobj	macrophages,in
R14281	T27463	T27459	agent	by,suppressed
R14282	T27464	T27468	det	a,pathway
R14283	T27486	T27488	compound	RA,fluids
R14284	T27465	T27468	nmod	protein,pathway
R14285	T27466	T27468	nmod	kinase,pathway
R14286	T27487	T27488	compound	synovial,fluids
R14287	T27467	T27468	compound	C-dependent,pathway
R14288	T27488	T27485	pobj	fluids,from
R14289	T27468	T27463	pobj	pathway,by
R14290	T27489	T27489	ROOT	are,are
R14291	T27469	T27468	acl	following,pathway
R14292	T27470	T27469	dobj	ligation,following
R14293	T27490	T27489	acomp	resistant,are
R14294	T27471	T27470	prep	of,ligation
R14295	T27491	T27490	prep	to,resistant
R14296	T27492	T27494	det	the,effect
R14297	T27496	T27495	pobj	IL-10,of
R14298	T27493	T27494	amod	immunoregulatory,effect
R14299	T27497	T27494	amod	due,effect
R14300	T27498	T27497	pcomp	to,due
R14301	T27494	T27491	pobj	effect,to
R14302	T27499	T27500	amod	decreased,transport
R14303	T27500	T27497	pobj	transport,due
R14304	T27501	T27500	prep	of,transport
R14305	T27502	T27503	amod	intracellular,IL-10R1
R14306	T27495	T27494	prep	of,effect
R14307	T27503	T27501	pobj	IL-10R1,of
R14308	T27504	T27500	prep	in,transport
R14309	T27568	T27567	prep	at,modulated
R14310	T27505	T27506	det	the,presence
R14311	T27506	T27504	pobj	presence,in
R14312	T27569	T27572	det	the,level
R14313	T27507	T27506	prep	of,presence
R14314	T27508	T27510	amod	proinflammatory,stimuli
R14315	T27509	T27510	compound	cytokine,stimuli
R14316	T27570	T27572	nmod	signal,level
R14317	T27510	T27507	pobj	stimuli,of
R14318	T27511	T27512	amod	such,as
R14319	T27512	T27510	prep	as,stimuli
R14320	T27571	T27572	compound	transduction,level
R14321	T27513	T27512	pobj	TNF-α,as
R14322	T27514	T27513	punct	",",TNF-α
R14323	T27515	T27513	conj	IL-1,TNF-α
R14324	T27516	T27515	punct	",",IL-1
R14325	T27517	T27515	cc	and,IL-1
R14326	T27518	T27515	conj	granulocyte,IL-1
R14327	T27572	T27568	pobj	level,at
R14328	T27519	T27521	compound	macrophage,factor
R14329	T27520	T27521	compound	colony-stimulating,factor
R14330	T27521	T27489	attr	factor,are
R14331	T27573	T27567	prep	under,modulated
R14332	T27522	T27524	nmod	[,]
R14333	T27523	T27524	nummod	15,]
R14334	T27524	T27521	appos	],factor
R14335	T27574	T27576	det	the,environment
R14336	T27525	T27489	punct	.,are
R14337	T27526	T27528	nsubj	We,demonstrated
R14338	T27575	T27576	amod	inflammatory,environment
R14339	T27576	T27573	pobj	environment,under
R14340	T27527	T27528	aux	have,demonstrated
R14341	T27577	T27567	prep	in,modulated
R14342	T27528	T27528	ROOT	demonstrated,demonstrated
R14343	T27529	T27535	mark	that,+
R14344	T27578	T27577	pobj	RA,in
R14345	T27530	T27531	det	the,resistance
R14346	T27531	T27535	nsubj	resistance,+
R14347	T27532	T27531	prep	of,resistance
R14348	T27579	T27567	punct	.,modulated
R14349	T27533	T27534	compound	RA,CD4
R14350	T27534	T27532	pobj	CD4,of
R14351	T27580	T27590	prep	In,found
R14352	T27535	T27542	csubjpass	+,associated
R14353	T27536	T27537	compound	T,cells
R14354	T27537	T27535	dobj	cells,+
R14355	T27538	T27535	prep	to,+
R14356	T27581	T27580	pobj	association,In
R14357	T27539	T27538	pobj	IL-10,to
R14358	T27540	T27542	aux	may,associated
R14359	T27582	T27581	prep	with,association
R14360	T27541	T27542	auxpass	be,associated
R14361	T27542	T27528	ccomp	associated,demonstrated
R14362	T27543	T27542	prep	with,associated
R14363	T27544	T27547	amod	defective,activation
R14364	T27583	T27586	amod	impaired,activation
R14365	T27545	T27547	amod	IL-10-dependent,activation
R14366	T27546	T27547	nummod	STAT3,activation
R14367	T27584	T27586	amod	IL-10-mediated,activation
R14368	T27547	T27543	pobj	activation,with
R14369	T27548	T27542	punct	",",associated
R14370	T27549	T27542	cc	but,associated
R14371	T27550	T27551	neg	not,with
R14372	T27585	T27586	nummod	STAT3,activation
R14373	T27551	T27542	conj	with,associated
R14374	T27552	T27553	amod	IL-10R1,expression
R14375	T27553	T27551	pobj	expression,with
R14376	T27554	T27528	punct	.,demonstrated
R14377	T27555	T27556	amod	Inhibitory,effects
R14378	T27586	T27582	pobj	activation,with
R14379	T27556	T27567	nsubjpass	effects,modulated
R14380	T27557	T27556	prep	of,effects
R14381	T27558	T27557	pobj	IL-10,of
R14382	T27587	T27590	punct	",",found
R14383	T27559	T27556	prep	on,effects
R14384	T27560	T27563	det	these,types
R14385	T27561	T27563	amod	inflammatory,types
R14386	T27588	T27590	nsubjpass	STAT3,found
R14387	T27562	T27563	compound	cell,types
R14388	T27563	T27559	pobj	types,on
R14389	T27564	T27567	auxpass	are,modulated
R14390	T27589	T27590	auxpass	was,found
R14391	T27565	T27567	advmod	therefore,modulated
R14392	T27566	T27567	advmod	differentially,modulated
R14393	T27590	T27590	ROOT	found,found
R14394	T27567	T27567	ROOT	modulated,modulated
R14395	T27591	T27592	aux	to,be
R14396	T27592	T27590	xcomp	be,found
R14397	T27601	T27594	punct	),phosphorylated
R14398	T27602	T27594	prep	in,phosphorylated
R14399	T27593	T27594	advmod	tyrosine,phosphorylated
R14400	T27603	T27604	advmod	freshly,isolated
R14401	T27594	T27592	attr	phosphorylated,be
R14402	T27604	T27605	amod	isolated,PB
R14403	T27605	T27602	pobj	PB,in
R14404	T27595	T27594	advmod	persistently,phosphorylated
R14405	T27606	T27605	cc	and,PB
R14406	T27607	T27605	conj	ST,PB
R14407	T27596	T27594	punct	(,phosphorylated
R14408	T27608	T27609	compound	CD4,+
R14409	T27609	T27590	advcl	+,found
R14410	T27610	T27611	compound	T,cells
R14411	T27597	T27599	quantmod	up,6
R14412	T27611	T27609	dobj	cells,+
R14413	T27612	T27609	prep	from,+
R14414	T27598	T27599	quantmod	to,6
R14415	T27613	T27614	compound	RA,patients
R14416	T27614	T27612	pobj	patients,from
R14417	T27615	T27590	punct	.,found
R14418	T27599	T27600	nummod	6,hours
R14419	T27616	T27618	nsubjpass	STAT3,activated
R14420	T27617	T27618	auxpass	is,activated
R14421	T27618	T27618	ROOT	activated,activated
R14422	T27600	T27594	appos	hours,phosphorylated
R14423	T27619	T27618	agent	by,activated
R14424	T27620	T27621	det	a,variety
R14425	T27621	T27619	pobj	variety,by
R14426	T27622	T27621	prep	of,variety
R14427	T27623	T27622	pobj	cytokines,of
R14428	T27624	T27621	punct	",",variety
R14429	T27656	T27618	punct	.,activated
R14430	T27625	T27628	advmod	notably,family
R14431	T27626	T27628	det	the,family
R14432	T27657	T27662	prep	Of,plays
R14433	T27627	T27628	compound	IL-6,family
R14434	T27628	T27621	appos	family,variety
R14435	T27629	T27628	prep	of,family
R14436	T27658	T27659	det	these,cytokines
R14437	T27630	T27629	pobj	cytokines,of
R14438	T27631	T27633	punct	(,IL-6
R14439	T27632	T27633	compound	e.g.,IL-6
R14440	T27659	T27657	pobj	cytokines,Of
R14441	T27633	T27628	appos	IL-6,family
R14442	T27634	T27633	punct	",",IL-6
R14443	T27660	T27662	punct	",",plays
R14444	T27635	T27633	conj	IL-11,IL-6
R14445	T27636	T27635	punct	",",IL-11
R14446	T27637	T27639	nmod	leukemia,factor
R14447	T27661	T27662	nsubj	IL-6,plays
R14448	T27638	T27639	amod	inhibitory,factor
R14449	T27639	T27635	appos	factor,IL-11
R14450	T27640	T27635	punct	",",IL-11
R14451	T27662	T27662	ROOT	plays,plays
R14452	T27641	T27635	cc	and,IL-11
R14453	T27642	T27643	compound	oncostatin,M
R14454	T27663	T27665	det	a,role
R14455	T27643	T27635	conj	M,IL-11
R14456	T27644	T27635	punct	),IL-11
R14457	T27645	T27633	cc	and,IL-6
R14458	T27664	T27665	amod	predominant,role
R14459	T27646	T27647	compound	growth,factors
R14460	T27647	T27628	appos	factors,family
R14461	T27648	T27628	punct	",",family
R14462	T27665	T27662	dobj	role,plays
R14463	T27649	T27628	prep	in,family
R14464	T27650	T27649	pobj	addition,in
R14465	T27666	T27665	prep	in,role
R14466	T27651	T27650	prep	to,addition
R14467	T27652	T27651	pobj	IL-10,to
R14468	T27653	T27655	nmod	[,]
R14469	T27667	T27666	pcomp	eliciting,in
R14470	T27654	T27655	nummod	4,]
R14471	T27655	T27652	dobj	],IL-10
R14472	T27668	T27670	det	a,reaction
R14473	T27669	T27670	amod	systemic,reaction
R14474	T27684	T27685	poss	its,abundance
R14475	T27670	T27667	dobj	reaction,eliciting
R14476	T27685	T27683	pobj	abundance,to
R14477	T27686	T27685	prep	in,abundance
R14478	T27671	T27672	amod	such,as
R14479	T27687	T27689	det	the,circulation
R14480	T27688	T27689	compound	blood,circulation
R14481	T27689	T27686	pobj	circulation,in
R14482	T27672	T27670	prep	as,reaction
R14483	T27690	T27692	nmod	[,]
R14484	T27691	T27692	nummod	27,]
R14485	T27673	T27676	det	the,response
R14486	T27692	T27670	appos	],reaction
R14487	T27693	T27662	punct	.,plays
R14488	T27674	T27676	amod	acute,response
R14489	T27694	T27700	advcl	Consistent,was
R14490	T27695	T27694	prep	with,Consistent
R14491	T27696	T27697	det	this,notion
R14492	T27675	T27676	compound	phase,response
R14493	T27697	T27695	pobj	notion,with
R14494	T27698	T27700	punct	",",was
R14495	T27676	T27672	pobj	response,as
R14496	T27699	T27700	nsubj	IL-6,was
R14497	T27700	T27700	ROOT	was,was
R14498	T27701	T27704	det	the,factor
R14499	T27677	T27676	prep	in,response
R14500	T27702	T27704	amod	major,factor
R14501	T27703	T27704	amod	STAT3-activating,factor
R14502	T27678	T27679	amod	active,RA
R14503	T27704	T27700	attr	factor,was
R14504	T27705	T27704	acl	contained,factor
R14505	T27706	T27705	prep	in,contained
R14506	T27679	T27677	pobj	RA,in
R14507	T27707	T27708	det	the,serum
R14508	T27708	T27706	pobj	serum,in
R14509	T27709	T27708	prep	of,serum
R14510	T27680	T27676	punct	",",response
R14511	T27710	T27712	amod	active,patients
R14512	T27711	T27712	compound	RA,patients
R14513	T27681	T27670	amod	due,reaction
R14514	T27712	T27709	pobj	patients,of
R14515	T27682	T27681	advmod	mainly,due
R14516	T27713	T27700	punct	",",was
R14517	T27714	T27700	cc	and,was
R14518	T27683	T27681	pcomp	to,due
R14519	T27715	T27716	det	the,responsiveness
R14520	T27716	T27720	nsubjpass	responsiveness,suppressed
R14521	T27742	T27743	nummod	STAT3,activation
R14522	T27717	T27716	prep	to,responsiveness
R14523	T27718	T27717	pobj	IL-10,to
R14524	T27719	T27720	auxpass	was,suppressed
R14525	T27720	T27700	conj	suppressed,was
R14526	T27721	T27720	prep	in,suppressed
R14527	T27722	T27726	amod	normal,cells
R14528	T27723	T27726	compound	CD4,cells
R14529	T27743	T27759	nsubjpass	activation,induced
R14530	T27724	T27726	nummod	+,cells
R14531	T27725	T27726	compound	T,cells
R14532	T27726	T27721	pobj	cells,in
R14533	T27727	T27720	prep	after,suppressed
R14534	T27744	T27743	cc	and,activation
R14535	T27728	T27729	nummod	36,hours
R14536	T27729	T27727	pobj	hours,after
R14537	T27730	T27729	prep	of,hours
R14538	T27745	T27746	det	the,resistance
R14539	T27731	T27730	pobj	incubation,of
R14540	T27732	T27720	prep	with,suppressed
R14541	T27746	T27743	conj	resistance,activation
R14542	T27733	T27732	pobj	IL-6,with
R14543	T27734	T27720	punct	.,suppressed
R14544	T27735	T27736	det	These,results
R14545	T27747	T27746	prep	to,resistance
R14546	T27736	T27737	nsubj	results,suggest
R14547	T27737	T27737	ROOT	suggest,suggest
R14548	T27738	T27759	mark	that,induced
R14549	T27748	T27749	compound	IL-10,inhibition
R14550	T27739	T27743	preconj	both,activation
R14551	T27740	T27743	det	the,activation
R14552	T27741	T27743	amod	sustained,activation
R14553	T27749	T27747	pobj	inhibition,to
R14554	T27750	T27749	acl	found,inhibition
R14555	T27751	T27750	prep	in,found
R14556	T27752	T27753	compound	RA,CD4
R14557	T27753	T27751	pobj	CD4,in
R14558	T27839	T27840	det	a,defect
R14559	T27840	T27838	dobj	defect,showed
R14560	T27754	T27756	amod	+,cells
R14561	T27841	T27840	prep	in,defect
R14562	T27842	T27846	det	the,pathway
R14563	T27755	T27756	compound	T,cells
R14564	T27843	T27846	amod	IL-10-induced,pathway
R14565	T27844	T27846	nummod	STAT3,pathway
R14566	T27845	T27846	amod	signaling,pathway
R14567	T27756	T27759	nsubjpass	cells,induced
R14568	T27846	T27841	pobj	pathway,in
R14569	T27847	T27838	punct	.,showed
R14570	T27848	T27849	nsubj	It,is
R14571	T27757	T27759	aux	may,induced
R14572	T27849	T27849	ROOT	is,is
R14573	T27850	T27851	advmod	most,probable
R14574	T27851	T27849	acomp	probable,is
R14575	T27852	T27865	mark	that,augmented
R14576	T27853	T27854	det	the,resistance
R14577	T27758	T27759	auxpass	be,induced
R14578	T27854	T27865	nsubjpass	resistance,augmented
R14579	T27855	T27854	prep	of,resistance
R14580	T27856	T27855	pobj	CD4,of
R14581	T27759	T27737	ccomp	induced,suggest
R14582	T27857	T27859	nummod	+,cells
R14583	T27858	T27859	compound	T,cells
R14584	T27859	T27854	conj	cells,resistance
R14585	T27760	T27759	prep	after,induced
R14586	T27860	T27859	prep	to,cells
R14587	T27861	T27860	pobj	IL-10,to
R14588	T27862	T27865	aux	can,augmented
R14589	T27761	T27762	amod	chronic,exposure
R14590	T27863	T27865	auxpass	be,augmented
R14591	T27864	T27865	advmod	even,augmented
R14592	T27865	T27849	ccomp	augmented,is
R14593	T27866	T27865	prep	after,augmented
R14594	T27762	T27760	pobj	exposure,after
R14595	T27867	T27866	pobj	migration,after
R14596	T27868	T27867	prep	into,migration
R14597	T27869	T27871	det	the,ST
R14598	T27763	T27762	prep	in,exposure
R14599	T27870	T27871	amod	inflamed,ST
R14600	T27871	T27868	pobj	ST,into
R14601	T27872	T27865	punct	",",augmented
R14602	T27764	T27763	pobj	vivo,in
R14603	T27873	T27877	mark	because,concentrated
R14604	T27765	T27762	prep	to,exposure
R14605	T27766	T27767	amod	high,concentrations
R14606	T27874	T27877	nsubjpass	IL-6,concentrated
R14607	T27875	T27877	auxpass	is,concentrated
R14608	T27876	T27877	advmod	highly,concentrated
R14609	T27767	T27765	pobj	concentrations,to
R14610	T27877	T27865	advcl	concentrated,augmented
R14611	T27878	T27877	prep	compared,concentrated
R14612	T27768	T27767	prep	of,concentrations
R14613	T27879	T27878	prep	with,compared
R14614	T27880	T27882	det	the,level
R14615	T27881	T27882	compound	blood,level
R14616	T27882	T27879	pobj	level,with
R14617	T27769	T27770	compound	serum,IL-6
R14618	T27883	T27885	nmod	[,]
R14619	T27884	T27885	nummod	27,]
R14620	T27885	T27882	appos	],level
R14621	T27770	T27768	pobj	IL-6,of
R14622	T27886	T27849	punct	.,is
R14623	T27887	T27901	prep	In,suggested
R14624	T27888	T27887	pobj	addition,In
R14625	T27889	T27901	punct	",",suggested
R14626	T27890	T27891	det	the,involvement
R14627	T27891	T27901	nsubjpass	involvement,suggested
R14628	T27771	T27737	punct	.,suggest
R14629	T27892	T27891	prep	of,involvement
R14630	T27893	T27896	amod	other,cytokines
R14631	T27894	T27896	amod	essential,cytokines
R14632	T27772	T27775	advmod	However,is
R14633	T27895	T27896	compound	proinflammatory,cytokines
R14634	T27896	T27892	pobj	cytokines,of
R14635	T27897	T27896	prep	in,cytokines
R14636	T27773	T27775	punct	",",is
R14637	T27898	T27899	det	this,process
R14638	T27899	T27897	pobj	process,in
R14639	T27900	T27901	auxpass	was,suggested
R14640	T27774	T27775	nsubj	it,is
R14641	T27901	T27901	ROOT	suggested,suggested
R14642	T27902	T27901	agent	by,suggested
R14643	T27903	T27905	poss	our,experiments
R14644	T27775	T27775	ROOT	is,is
R14645	T27904	T27905	amod	preliminary,experiments
R14646	T27905	T27902	pobj	experiments,by
R14647	T27906	T27905	acl	demonstrating,experiments
R14648	T27776	T27775	advmod	also,is
R14649	T27907	T27917	mark	that,reduced
R14650	T27908	T27910	amod	IL-10-mediated,inhibition
R14651	T27909	T27910	amod	IFN-γ,inhibition
R14652	T27777	T27775	acomp	possible,is
R14653	T27910	T27917	nsubjpass	inhibition,reduced
R14654	T27911	T27910	prep	in,inhibition
R14655	T27912	T27911	pobj	CD4,in
R14656	T27778	T27784	mark	that,induced
R14657	T27913	T27915	compound	+,cells
R14658	T27914	T27915	compound	T,cells
R14659	T27779	T27780	amod	STAT3,activity
R14660	T27915	T27910	conj	cells,inhibition
R14661	T27916	T27917	auxpass	was,reduced
R14662	T27917	T27906	ccomp	reduced,demonstrating
R14663	T27780	T27784	nsubjpass	activity,induced
R14664	T27781	T27784	aux	could,induced
R14665	T27918	T27917	prep	by,reduced
R14666	T27782	T27784	auxpass	be,induced
R14667	T27919	T27918	pobj	pretreatment,by
R14668	T27920	T27917	prep	with,reduced
R14669	T27921	T27920	pobj	IL-1β,with
R14670	T27783	T27784	advmod	constitutively,induced
R14671	T27922	T27921	cc	and,IL-1β
R14672	T27923	T27921	conj	TNF-α,IL-1β
R14673	T27784	T27775	ccomp	induced,is
R14674	T27924	T27917	punct	",",reduced
R14675	T27925	T27934	mark	although,shown
R14676	T27926	T27927	advmod	less,effectively
R14677	T27927	T27934	advmod	effectively,shown
R14678	T27928	T27927	prep	than,effectively
R14679	T27785	T27784	prep	in,induced
R14680	T27929	T27928	prep	by,than
R14681	T27930	T27929	pobj	IL-6,by
R14682	T27931	T27934	punct	(,shown
R14683	T27786	T27789	nummod	CD4,cells
R14684	T27932	T27934	nsubjpass	data,shown
R14685	T27933	T27934	neg	not,shown
R14686	T27934	T27917	advcl	shown,reduced
R14687	T27787	T27789	nummod	+,cells
R14688	T27935	T27917	punct	),reduced
R14689	T27936	T27901	punct	.,suggested
R14690	T27937	T27942	advmod	Furthermore,produced
R14691	T27788	T27789	compound	T,cells
R14692	T27938	T27942	punct	",",produced
R14693	T27939	T27942	nsubj	IFN-γ,produced
R14694	T27789	T27785	pobj	cells,in
R14695	T27940	T27939	cc	and,IFN-γ
R14696	T27941	T27939	conj	IL-10,IFN-γ
R14697	T27942	T27950	nsubj	produced,be
R14698	T27790	T27784	agent	by,induced
R14699	T27791	T27794	poss	their,secretion
R14700	T27943	T27942	agent	by,produced
R14701	T27944	T27947	compound	CD4,cells
R14702	T27792	T27794	amod	own,secretion
R14703	T27945	T27947	compound	+,cells
R14704	T27946	T27947	compound	T,cells
R14705	T27793	T27794	compound	IL-10,secretion
R14706	T27947	T27943	pobj	cells,by
R14707	T27948	T27947	appos	themselves,cells
R14708	T27949	T27950	aux	could,be
R14709	T27794	T27790	pobj	secretion,by
R14710	T27950	T27950	ROOT	be,be
R14711	T27951	T27950	acomp	responsible,be
R14712	T27952	T27951	prep	for,responsible
R14713	T27795	T27784	punct	",",induced
R14714	T27953	T27955	amod	impaired,signaling
R14715	T27954	T27955	compound	IL-10,signaling
R14716	T27955	T27952	pobj	signaling,for
R14717	T27796	T27784	advcl	leading,induced
R14718	T27956	T27955	prep	in,signaling
R14719	T27957	T27958	det	the,ST
R14720	T27958	T27956	pobj	ST,in
R14721	T27797	T27796	prep	to,leading
R14722	T27959	T27950	punct	",",be
R14723	T27960	T27963	mark	because,produce
R14724	T27798	T27799	det	the,loss
R14725	T27961	T27962	compound	T-cell,infiltrates
R14726	T27962	T27963	nsubj	infiltrates,produce
R14727	T27963	T27950	advcl	produce,be
R14728	T27964	T27968	det	both,]
R14729	T27965	T27968	nmod	cytokines,]
R14730	T27966	T27968	nmod	[,]
R14731	T27799	T27797	pobj	loss,to
R14732	T27967	T27968	nummod	"34,35",]
R14733	T27968	T27963	dobj	],produce
R14734	T27800	T27799	prep	of,loss
R14735	T27801	T27800	pobj	sensitivity,of
R14736	T27969	T27950	punct	.,be
R14737	T27970	T27978	prep	In,stimulate
R14738	T27802	T27801	prep	to,sensitivity
R14739	T27971	T27973	det	an,fashion
R14740	T27972	T27973	amod	autocrine,fashion
R14741	T27973	T27970	pobj	fashion,In
R14742	T27803	T27804	amod	exogenous,IL-10
R14743	T27974	T27978	punct	",",stimulate
R14744	T27975	T27978	nsubj	IL-10,stimulate
R14745	T27804	T27802	pobj	IL-10,to
R14746	T27976	T27978	aux	may,stimulate
R14747	T27977	T27978	advmod	persistently,stimulate
R14748	T27978	T27978	ROOT	stimulate,stimulate
R14749	T27805	T27784	punct	",",induced
R14750	T27979	T27980	amod	STAT3,activation
R14751	T27980	T27978	dobj	activation,stimulate
R14752	T27981	T27980	cc	and,activation
R14753	T27806	T27809	mark	because,+
R14754	T27982	T27980	conj	IFN-γ,activation
R14755	T27983	T27984	aux	can,induce
R14756	T27984	T27978	conj	induce,stimulate
R14757	T27807	T27808	compound	RA,CD4
R14758	T27985	T27986	nummod	SOCS1,protein
R14759	T27986	T27984	dobj	protein,induce
R14760	T27987	T27984	prep	as,induce
R14761	T27808	T27809	nsubj	CD4,+
R14762	T27988	T27990	det	a,inhibitor
R14763	T27989	T27990	compound	crosstalk,inhibitor
R14764	T27990	T27987	pobj	inhibitor,as
R14765	T27809	T27784	advcl	+,induced
R14766	T27991	T27990	prep	of,inhibitor
R14767	T27992	T27991	pobj	IL-10,of
R14768	T27993	T27984	advcl	signaling,induce
R14769	T27810	T27811	compound	T,cells
R14770	T27994	T27996	nmod	[,]
R14771	T27995	T27996	nummod	32,]
R14772	T27996	T27993	dobj	],signaling
R14773	T27811	T27809	dobj	cells,+
R14774	T27812	T27809	prep	in,+
R14775	T27997	T27978	punct	.,stimulate
R14776	T27998	T28000	det	The,effect
R14777	T27999	T28000	amod	T-cell-inhibitory,effect
R14778	T28000	T28006	nsubjpass	effect,modulated
R14779	T28001	T28000	prep	of,effect
R14780	T27813	T27814	det	the,ST
R14781	T28002	T28001	pobj	IL-10,of
R14782	T28003	T28006	aux	may,modulated
R14783	T28004	T28006	advmod	therefore,modulated
R14784	T27814	T27812	pobj	ST,in
R14785	T28005	T28006	auxpass	be,modulated
R14786	T28006	T28006	ROOT	modulated,modulated
R14787	T27815	T27784	conj	are,induced
R14788	T28007	T28006	advmod	complicatedly,modulated
R14789	T28008	T28006	prep	upon,modulated
R14790	T28009	T28008	pobj	exposure,upon
R14791	T27816	T27815	acomp	capable,are
R14792	T28010	T28009	prep	to,exposure
R14793	T28011	T28013	det	an,environment
R14794	T28012	T28013	amod	inflammatory,environment
R14795	T27817	T27816	prep	of,capable
R14796	T28013	T28010	pobj	environment,to
R14797	T28014	T28013	prep	in,environment
R14798	T28015	T28016	compound	RA,joints
R14799	T27818	T27817	pcomp	producing,of
R14800	T28016	T28014	pobj	joints,in
R14801	T28017	T28016	punct	",",joints
R14802	T28018	T28021	advmod	where,are
R14803	T27819	T27820	amod	significant,levels
R14804	T28019	T28020	amod	many,cytokines
R14805	T28020	T28021	nsubj	cytokines,are
R14806	T27820	T27818	dobj	levels,producing
R14807	T28021	T28013	relcl	are,environment
R14808	T28022	T28021	acomp	present,are
R14809	T28023	T28026	advmod	substantially,]
R14810	T27821	T27820	prep	of,levels
R14811	T28024	T28026	nmod	[,]
R14812	T28025	T28026	nummod	10,]
R14813	T27822	T27823	compound	IL-10,[
R14814	T28026	T28013	appos	],environment
R14815	T28027	T28006	punct	.,modulated
R14816	T28028	T28029	nummod	STAT3,activation
R14817	T28029	T28032	nsubjpass	activation,implicated
R14818	T27823	T27821	pobj	[,of
R14819	T28030	T28032	aux	has,implicated
R14820	T28031	T28032	auxpass	been,implicated
R14821	T27824	T27825	nummod	34,]
R14822	T28032	T28032	ROOT	implicated,implicated
R14823	T28033	T28032	prep	in,implicated
R14824	T28034	T28035	det	the,pathogenesis
R14825	T28035	T28033	pobj	pathogenesis,in
R14826	T28036	T28035	prep	of,pathogenesis
R14827	T28037	T28036	pobj	RA,of
R14828	T28038	T28032	punct	.,implicated
R14829	T27825	T27815	npadvmod	],are
R14830	T28039	T28040	compound	Active,STAT3
R14831	T28040	T28043	nsubjpass	STAT3,expressed
R14832	T28041	T28043	auxpass	is,expressed
R14833	T27826	T27775	punct	.,is
R14834	T28042	T28043	advmod	constitutively,expressed
R14835	T28043	T28043	ROOT	expressed,expressed
R14836	T27827	T27830	nummod	CD4,cells
R14837	T27828	T27830	nummod	+,cells
R14838	T27829	T27830	compound	T,cells
R14839	T28044	T28043	prep	in,expressed
R14840	T28045	T28048	amod	synovial,cells
R14841	T27830	T27831	nsubj	cells,isolated
R14842	T28046	T28048	amod	fluid,cells
R14843	T28047	T28048	compound	mononuclear,cells
R14844	T28048	T28044	pobj	cells,in
R14845	T27831	T27838	nsubj	isolated,showed
R14846	T28049	T28048	prep	from,cells
R14847	T28050	T28051	compound	RA,patients
R14848	T27832	T27831	prep	from,isolated
R14849	T28051	T28049	pobj	patients,from
R14850	T28052	T28054	nmod	[,]
R14851	T28053	T28054	nummod	36,]
R14852	T27833	T27834	det	the,ST
R14853	T28054	T28048	appos	],cells
R14854	T28055	T28043	punct	.,expressed
R14855	T27834	T27832	pobj	ST,from
R14856	T28056	T28057	nsubj	IL-6,is
R14857	T28057	T28057	ROOT	is,is
R14858	T28058	T28062	det	the,present
R14859	T28059	T28062	amod	major,present
R14860	T27835	T27834	prep	of,ST
R14861	T28060	T28061	amod	STAT3-activating,factor
R14862	T28061	T28062	compound	factor,present
R14863	T28062	T28057	attr	present,is
R14864	T28063	T28062	prep	in,present
R14865	T27836	T27835	pobj	RA,of
R14866	T28064	T28065	amod	synovial,fluid
R14867	T28065	T28063	pobj	fluid,in
R14868	T27837	T27838	advmod	also,showed
R14869	T28066	T28065	punct	",",fluid
R14870	T28067	T28068	nsubj	which,has
R14871	T28068	T28062	relcl	has,present
R14872	T28069	T28071	det	a,role
R14873	T27838	T27838	ROOT	showed,showed
R14874	T28070	T28071	amod	crucial,role
R14875	T28071	T28068	dobj	role,has
R14876	T28072	T28071	prep	in,role
R14877	T28073	T28074	det	the,activation
R14878	T28074	T28072	pobj	activation,in
R14879	T28075	T28074	prep	of,activation
R14880	T28141	T28139	appos	],[
R14881	T28076	T28077	compound	monocyte,functions
R14882	T28142	T28108	punct	.,thought
R14883	T28077	T28075	pobj	functions,of
R14884	T28078	T28079	amod	such,as
R14885	T28079	T28077	prep	as,functions
R14886	T28143	T28148	prep	In,is
R14887	T28080	T28081	compound	gene,expression
R14888	T28081	T28079	pobj	expression,as
R14889	T28082	T28081	prep	of,expression
R14890	T28144	T28145	det	this,regard
R14891	T28083	T28087	det	the,type
R14892	T28084	T28087	compound	Fc,type
R14893	T28085	T28086	compound	gamma,receptor
R14894	T28145	T28143	pobj	regard,In
R14895	T28086	T28087	compound	receptor,type
R14896	T28087	T28082	pobj	type,of
R14897	T28146	T28148	punct	",",is
R14898	T28088	T28081	conj	I,expression
R14899	T28089	T28088	cc	and,I
R14900	T28090	T28091	compound	type,III
R14901	T28147	T28148	nsubj	STAT3,is
R14902	T28091	T28088	conj	III,I
R14903	T28092	T28088	cc	and,I
R14904	T28093	T28081	prep	of,expression
R14905	T28148	T28148	ROOT	is,is
R14906	T28094	T28095	compound	HLA-DR,[
R14907	T28095	T28093	pobj	[,of
R14908	T28096	T28097	nummod	31,]
R14909	T28149	T28148	acomp	critical,is
R14910	T28097	T28095	appos	],[
R14911	T28098	T28057	punct	.,is
R14912	T28099	T28100	advmod	More,recently
R14913	T28150	T28149	prep	in,critical
R14914	T28100	T28108	advmod	recently,thought
R14915	T28101	T28108	punct	",",thought
R14916	T28151	T28152	det	the,survival
R14917	T28102	T28103	amod	high,levels
R14918	T28103	T28108	nsubj	levels,thought
R14919	T28104	T28103	prep	of,levels
R14920	T28105	T28106	amod	activated,STAT3
R14921	T28152	T28159	nmod	survival,fibroblasts
R14922	T28106	T28104	pobj	STAT3,of
R14923	T28107	T28108	punct	",",thought
R14924	T28108	T28108	ROOT	thought,thought
R14925	T28109	T28111	aux	to,induced
R14926	T28110	T28111	auxpass	be,induced
R14927	T28111	T28108	xcomp	induced,thought
R14928	T28153	T28152	cc	and,survival
R14929	T28112	T28111	advmod	mainly,induced
R14930	T28113	T28111	agent	by,induced
R14931	T28114	T28113	pobj	IL-6,by
R14932	T28154	T28152	conj	expansion,survival
R14933	T28115	T28108	punct	",",thought
R14934	T28116	T28118	aux	have,detected
R14935	T28117	T28118	auxpass	been,detected
R14936	T28118	T28108	ccomp	detected,thought
R14937	T28119	T28118	prep	in,detected
R14938	T28155	T28154	prep	of,expansion
R14939	T28120	T28121	det	the,ST
R14940	T28121	T28119	pobj	ST,in
R14941	T28122	T28118	punct	",",detected
R14942	T28123	T28118	cc	and,detected
R14943	T28156	T28155	pobj	growth,of
R14944	T28124	T28125	compound	STAT3,activation
R14945	T28125	T28128	nsubjpass	activation,shown
R14946	T28126	T28128	aux	has,shown
R14947	T28157	T28159	nmod	factor-dependent,fibroblasts
R14948	T28127	T28128	auxpass	been,shown
R14949	T28128	T28118	conj	shown,detected
R14950	T28129	T28131	aux	to,involved
R14951	T28158	T28159	amod	synovial,fibroblasts
R14952	T28130	T28131	auxpass	be,involved
R14953	T28131	T28128	xcomp	involved,shown
R14954	T28159	T28150	pobj	fibroblasts,in
R14955	T28132	T28131	prep	in,involved
R14956	T28133	T28135	amod	synovial,proliferation
R14957	T28134	T28135	compound	fibroblast,proliferation
R14958	T28160	T28162	nmod	[,]
R14959	T28135	T28132	pobj	proliferation,in
R14960	T28136	T28135	cc	and,proliferation
R14961	T28137	T28138	compound	IL-6,production
R14962	T28161	T28162	nummod	38,]
R14963	T28138	T28139	compound	production,[
R14964	T28139	T28131	dobj	[,involved
R14965	T28140	T28141	nummod	37,]
R14966	T28245	T28240	prep	through,resistant
R14967	T28246	T28248	amod	gp130-mediated,activation
R14968	T28247	T28248	nummod	STAT3,activation
R14969	T28162	T28159	appos	],fibroblasts
R14970	T28163	T28148	punct	.,is
R14971	T28248	T28245	pobj	activation,through
R14972	T28164	T28178	advmod	Furthermore,suggested
R14973	T28165	T28178	punct	",",suggested
R14974	T28249	T28238	punct	.,activated
R14975	T28166	T28167	det	the,significance
R14976	T28167	T28178	nsubjpass	significance,suggested
R14977	T28168	T28167	prep	of,significance
R14978	T28169	T28171	amod	persistent,signaling
R14979	T28170	T28171	nummod	STAT3,signaling
R14980	T28171	T28168	pobj	signaling,of
R14981	T28172	T28171	prep	in,signaling
R14982	T28250	T28251	det	The,longevity
R14983	T28173	T28175	amod	Th1-cell-dominated,arthritis
R14984	T28174	T28175	amod	autoimmune,arthritis
R14985	T28175	T28172	pobj	arthritis,in
R14986	T28176	T28178	aux	has,suggested
R14987	T28251	T28262	nsubjpass	longevity,regulated
R14988	T28177	T28178	auxpass	been,suggested
R14989	T28178	T28178	ROOT	suggested,suggested
R14990	T28252	T28251	prep	of,longevity
R14991	T28179	T28178	agent	by,suggested
R14992	T28180	T28179	pobj	studies,by
R14993	T28181	T28180	prep	of,studies
R14994	T28253	T28254	compound	cytokine,signals
R14995	T28182	T28184	det	the,mice
R14996	T28183	T28184	compound	gp130F759/F759,mice
R14997	T28184	T28181	pobj	mice,of
R14998	T28254	T28252	pobj	signals,of
R14999	T28185	T28180	punct	",",studies
R15000	T28186	T28214	prep	in,mutated
R15001	T28255	T28251	acl	transduced,longevity
R15002	T28187	T28186	pobj	which,in
R15003	T28188	T28193	det	the,site
R15004	T28189	T28193	nmod	Src,site
R15005	T28256	T28255	agent	by,transduced
R15006	T28190	T28193	nmod	homology,site
R15007	T28191	T28193	amod	phosphatase-2,site
R15008	T28192	T28193	amod	binding,site
R15009	T28257	T28258	det	the,JAK
R15010	T28193	T28214	nsubjpass	site,mutated
R15011	T28194	T28193	prep	of,site
R15012	T28195	T28194	pobj	gp130,of
R15013	T28258	T28256	pobj	JAK,by
R15014	T28196	T28195	punct	(,gp130
R15015	T28197	T28201	det	the,subunit
R15016	T28198	T28201	nmod	transmembrane,subunit
R15017	T28259	T28260	compound	STAT,pathway
R15018	T28199	T28201	nmod	glycoprotein,subunit
R15019	T28260	T28262	nsubjpass	pathway,regulated
R15020	T28261	T28262	auxpass	is,regulated
R15021	T28200	T28201	compound	β,subunit
R15022	T28201	T28195	appos	subunit,gp130
R15023	T28202	T28201	prep	of,subunit
R15024	T28262	T28262	ROOT	regulated,regulated
R15025	T28203	T28207	det	the,receptor
R15026	T28204	T28205	compound	IL-6,family
R15027	T28205	T28207	nmod	family,receptor
R15028	T28206	T28207	compound	cytokine,receptor
R15029	T28207	T28202	pobj	receptor,of
R15030	T28263	T28262	agent	by,regulated
R15031	T28208	T28195	punct	),gp130
R15032	T28209	T28193	punct	",",site
R15033	T28210	T28211	amod	tyrosine,759
R15034	T28264	T28267	det	the,proteins
R15035	T28211	T28193	appos	759,site
R15036	T28212	T28214	punct	",",mutated
R15037	T28213	T28214	auxpass	was,mutated
R15038	T28214	T28180	relcl	mutated,studies
R15039	T28265	T28266	compound	SOCS,family
R15040	T28215	T28216	aux	to,phenylalanine
R15041	T28216	T28214	advcl	phenylalanine,mutated
R15042	T28266	T28267	compound	family,proteins
R15043	T28217	T28216	dobj	[,phenylalanine
R15044	T28218	T28219	nummod	39,]
R15045	T28219	T28217	appos	],[
R15046	T28267	T28263	pobj	proteins,by
R15047	T28220	T28178	punct	.,suggested
R15048	T28221	T28238	prep	In,activated
R15049	T28222	T28224	det	the,mice
R15050	T28268	T28270	nmod	[,]
R15051	T28223	T28224	compound	gp130F759/F759,mice
R15052	T28224	T28221	pobj	mice,In
R15053	T28225	T28238	punct	",",activated
R15054	T28269	T28270	nummod	7,]
R15055	T28226	T28227	compound	T,cells
R15056	T28227	T28238	nsubjpass	cells,activated
R15057	T28228	T28227	punct	",",cells
R15058	T28270	T28262	npadvmod	],regulated
R15059	T28229	T28234	advmod	particularly,subset
R15060	T28230	T28234	det	the,subset
R15061	T28231	T28234	compound	CD4,subset
R15062	T28271	T28262	punct	.,regulated
R15063	T28232	T28234	compound	+,subset
R15064	T28272	T28273	nsubj	We,found
R15065	T28233	T28234	compound	T-cell,subset
R15066	T28234	T28227	appos	subset,cells
R15067	T28273	T28273	ROOT	found,found
R15068	T28235	T28238	punct	",",activated
R15069	T28236	T28238	auxpass	are,activated
R15070	T28274	T28284	mark	that,expressed
R15071	T28237	T28238	advmod	chronically,activated
R15072	T28238	T28238	ROOT	activated,activated
R15073	T28239	T28238	cc	and,activated
R15074	T28275	T28278	nummod	CD4,cells
R15075	T28240	T28238	conj	resistant,activated
R15076	T28241	T28244	nmod	to,death
R15077	T28242	T28244	amod	activation-induced,death
R15078	T28243	T28244	compound	cell,death
R15079	T28244	T28240	dobj	death,resistant
R15080	T28276	T28278	nummod	+,cells
R15081	T28277	T28278	compound	T,cells
R15082	T28278	T28284	nsubj	cells,expressed
R15083	T28279	T28278	prep	from,cells
R15084	T28342	T28343	auxpass	are,induced
R15085	T28280	T28279	pobj	patients,from
R15086	T28343	T28343	ROOT	induced,induced
R15087	T28344	T28343	agent	by,induced
R15088	T28345	T28346	amod	various,cytokines
R15089	T28281	T28280	prep	with,patients
R15090	T28346	T28344	pobj	cytokines,by
R15091	T28347	T28346	punct	",",cytokines
R15092	T28348	T28346	prep	including,cytokines
R15093	T28282	T28283	amod	active,RA
R15094	T28349	T28348	pobj	IL-6,including
R15095	T28350	T28349	cc	and,IL-6
R15096	T28351	T28349	conj	IL-10,IL-6
R15097	T28283	T28281	pobj	RA,with
R15098	T28352	T28343	punct	",",induced
R15099	T28353	T28343	prep	as,induced
R15100	T28354	T28353	pobj	mediators,as
R15101	T28355	T28354	prep	of,mediators
R15102	T28284	T28273	ccomp	expressed,found
R15103	T28356	T28357	amod	negative,feedback
R15104	T28357	T28355	pobj	feedback,of
R15105	T28358	T28357	cc	and,feedback
R15106	T28285	T28286	amod	higher,levels
R15107	T28359	T28360	compound	crosstalk,inhibition
R15108	T28360	T28361	compound	inhibition,[
R15109	T28361	T28354	appos	[,mediators
R15110	T28286	T28284	dobj	levels,expressed
R15111	T28362	T28361	nummod	7,[
R15112	T28363	T28361	appos	],[
R15113	T28364	T28343	punct	.,induced
R15114	T28287	T28286	prep	of,levels
R15115	T28365	T28366	amod	Recent,studies
R15116	T28366	T28373	nsubj	studies,revealed
R15117	T28367	T28366	prep	with,studies
R15118	T28288	T28287	pobj	SOCS1,of
R15119	T28368	T28367	pobj	mice,with
R15120	T28369	T28366	acl	lacking,studies
R15121	T28370	T28369	dobj	SOCS3,lacking
R15122	T28289	T28284	punct	",",expressed
R15123	T28371	T28370	cc	or,SOCS3
R15124	T28372	T28370	conj	SOCS1,SOCS3
R15125	T28373	T28373	ROOT	revealed,revealed
R15126	T28374	T28376	mark	that,is
R15127	T28375	T28376	nsubj	SOCS3,is
R15128	T28290	T28284	cc	but,expressed
R15129	T28376	T28373	ccomp	is,revealed
R15130	T28377	T28379	det	a,regulator
R15131	T28378	T28379	amod	negative,regulator
R15132	T28291	T28292	amod	lower,levels
R15133	T28379	T28376	attr	regulator,is
R15134	T28380	T28379	prep	of,regulator
R15135	T28381	T28380	pobj	IL-6,of
R15136	T28292	T28296	nsubj	levels,compared
R15137	T28382	T28380	pcomp	signaling,of
R15138	T28383	T28385	cc	but,of
R15139	T28384	T28385	neg	not,of
R15140	T28293	T28292	prep	of,levels
R15141	T28385	T28382	prep	of,signaling
R15142	T28386	T28385	pobj	IL-10,of
R15143	T28294	T28293	pobj	SOCS3,of
R15144	T28387	T28382	conj	signaling,signaling
R15145	T28295	T28296	punct	",",compared
R15146	T28388	T28373	punct	.,revealed
R15147	T28389	T28395	nsubj	Studies,shown
R15148	T28296	T28284	conj	compared,expressed
R15149	T28390	T28389	prep	of,Studies
R15150	T28391	T28393	amod	conditional,mice
R15151	T28392	T28393	amod	SOCS3-deficient,mice
R15152	T28393	T28390	pobj	mice,of
R15153	T28297	T28296	prep	with,compared
R15154	T28394	T28395	aux	have,shown
R15155	T28395	T28395	ROOT	shown,shown
R15156	T28396	T28398	det	that,deficiency
R15157	T28298	T28302	amod	normal,cells
R15158	T28397	T28398	nummod	SOCS3,deficiency
R15159	T28398	T28395	dobj	deficiency,shown
R15160	T28299	T28302	compound	CD4,cells
R15161	T28399	T28398	punct	",",deficiency
R15162	T28400	T28398	cc	but,deficiency
R15163	T28401	T28403	neg	not,deficiency
R15164	T28300	T28302	nummod	+,cells
R15165	T28402	T28403	nummod	SOCS1,deficiency
R15166	T28403	T28398	conj	deficiency,deficiency
R15167	T28404	T28403	punct	",",deficiency
R15168	T28301	T28302	compound	T,cells
R15169	T28405	T28398	conj	results,deficiency
R15170	T28406	T28405	prep	in,results
R15171	T28407	T28408	amod	sustained,activation
R15172	T28302	T28297	pobj	cells,with
R15173	T28408	T28406	pobj	activation,in
R15174	T28409	T28408	prep	of,activation
R15175	T28410	T28409	pobj	STAT3,of
R15176	T28411	T28398	prep	in,deficiency
R15177	T28412	T28411	pobj	response,in
R15178	T28413	T28412	prep	to,response
R15179	T28303	T28273	punct	.,found
R15180	T28414	T28417	compound	IL-6,]
R15181	T28415	T28417	compound	[,]
R15182	T28416	T28417	compound	"8,41",]
R15183	T28417	T28413	pobj	],to
R15184	T28304	T28305	nsubj	SOCS1,prevents
R15185	T28418	T28395	punct	.,shown
R15186	T28419	T28420	det	The,analysis
R15187	T28305	T28305	ROOT	prevents,prevents
R15188	T28420	T28425	nsubj	analysis,indicated
R15189	T28421	T28420	prep	of,analysis
R15190	T28422	T28423	amod	SOCS3-deficient,macrophages
R15191	T28423	T28421	pobj	macrophages,of
R15192	T28306	T28305	dobj	activation,prevents
R15193	T28424	T28425	aux	has,indicated
R15194	T28425	T28425	ROOT	indicated,indicated
R15195	T28307	T28306	prep	of,activation
R15196	T28426	T28428	mark	that,is
R15197	T28427	T28428	nsubj	SOCS3,is
R15198	T28428	T28425	ccomp	is,indicated
R15199	T28308	T28307	pobj	JAK,of
R15200	T28429	T28431	det	a,inhibitor
R15201	T28430	T28431	amod	crucial,inhibitor
R15202	T28431	T28428	attr	inhibitor,is
R15203	T28309	T28305	prep	by,prevents
R15204	T28432	T28431	prep	of,inhibitor
R15205	T28433	T28436	det	the,response
R15206	T28434	T28436	amod	IL-6-induced,response
R15207	T28310	T28311	advmod	directly,binding
R15208	T28435	T28436	amod	transcriptional,response
R15209	T28436	T28432	pobj	response,of
R15210	T28437	T28439	nmod	[,]
R15211	T28438	T28439	nummod	42,]
R15212	T28311	T28309	pcomp	binding,by
R15213	T28312	T28311	prep	to,binding
R15214	T28313	T28312	pobj	JAK,to
R15215	T28439	T28436	appos	],response
R15216	T28440	T28425	punct	.,indicated
R15217	T28314	T28305	punct	",",prevents
R15218	T28441	T28444	advmod	However,is
R15219	T28442	T28444	punct	",",is
R15220	T28315	T28305	cc	and,prevents
R15221	T28443	T28444	nsubj	SOCS3,is
R15222	T28444	T28444	ROOT	is,is
R15223	T28445	T28444	acomp	dispensable,is
R15224	T28316	T28317	nsubj	SOCS3,inhibits
R15225	T28446	T28445	prep	for,dispensable
R15226	T28447	T28451	preconj	both,inhibition
R15227	T28448	T28451	det	the,inhibition
R15228	T28449	T28451	amod	negative,inhibition
R15229	T28450	T28451	compound	feedback,inhibition
R15230	T28451	T28446	pobj	inhibition,for
R15231	T28452	T28451	cc	and,inhibition
R15232	T28317	T28305	conj	inhibits,prevents
R15233	T28453	T28455	det	the,action
R15234	T28454	T28455	amod	immunoregulatory,action
R15235	T28455	T28451	conj	action,inhibition
R15236	T28318	T28319	det	the,action
R15237	T28456	T28455	prep	of,action
R15238	T28457	T28456	pobj	IL-10,of
R15239	T28319	T28317	dobj	action,inhibits
R15240	T28458	T28455	prep	in,action
R15241	T28459	T28458	pobj	macrophages,in
R15242	T28460	T28462	nmod	[,]
R15243	T28320	T28319	prep	of,action
R15244	T28461	T28462	nummod	41,]
R15245	T28462	T28455	appos	],action
R15246	T28463	T28444	punct	.,is
R15247	T28321	T28320	pobj	JAK,of
R15248	T28464	T28470	prep	On,found
R15249	T28465	T28466	det	the,contrary
R15250	T28466	T28464	pobj	contrary,On
R15251	T28322	T28319	prep	by,action
R15252	T28323	T28322	pcomp	binding,by
R15253	T28467	T28470	punct	",",found
R15254	T28468	T28470	nsubjpass	SOCS1,found
R15255	T28324	T28323	prep	to,binding
R15256	T28469	T28470	auxpass	was,found
R15257	T28470	T28470	ROOT	found,found
R15258	T28325	T28329	det	the,domain
R15259	T28471	T28473	aux	to,inhibit
R15260	T28472	T28473	advmod	directly,inhibit
R15261	T28473	T28470	advcl	inhibit,found
R15262	T28326	T28329	nmod	Src,domain
R15263	T28474	T28475	npadvmod	IL-10-mediated,signaling
R15264	T28475	T28478	amod	signaling,]
R15265	T28327	T28329	nmod	homology,domain
R15266	T28476	T28478	nmod	[,]
R15267	T28477	T28478	nummod	43,]
R15268	T28328	T28329	amod	phosphatase-2-binding,domain
R15269	T28478	T28473	dobj	],inhibit
R15270	T28479	T28470	punct	.,found
R15271	T28480	T28482	amod	Increased,expression
R15272	T28329	T28324	pobj	domain,to
R15273	T28481	T28482	nummod	SOCS1,expression
R15274	T28482	T28492	nsubjpass	expression,associated
R15275	T28483	T28482	prep	in,expression
R15276	T28484	T28485	compound	RA,CD4
R15277	T28485	T28483	pobj	CD4,in
R15278	T28486	T28488	amod	+,cells
R15279	T28330	T28329	prep	of,domain
R15280	T28487	T28488	compound	T,cells
R15281	T28488	T28492	nsubjpass	cells,associated
R15282	T28489	T28492	aux	may,associated
R15283	T28490	T28492	advmod	therefore,associated
R15284	T28331	T28330	pobj	receptors,of
R15285	T28491	T28492	auxpass	be,associated
R15286	T28492	T28511	csubj	associated,be
R15287	T28332	T28333	amod	such,as
R15288	T28493	T28492	prep	with,associated
R15289	T28494	T28497	preconj	both,responsiveness
R15290	T28495	T28497	det	the,responsiveness
R15291	T28333	T28331	prep	as,receptors
R15292	T28496	T28497	amod	impaired,responsiveness
R15293	T28497	T28493	pobj	responsiveness,with
R15294	T28498	T28497	prep	to,responsiveness
R15295	T28334	T28337	nummod	gp130,]
R15296	T28499	T28498	pobj	IL-10,to
R15297	T28500	T28498	cc	and,to
R15298	T28335	T28337	nmod	[,]
R15299	T28501	T28498	conj	to,to
R15300	T28502	T28504	amod	IL-10-mediated,activation
R15301	T28503	T28504	nummod	STAT3,activation
R15302	T28504	T28501	pobj	activation,to
R15303	T28336	T28337	nummod	40,]
R15304	T28505	T28497	punct	",",responsiveness
R15305	T28506	T28497	cc	and,responsiveness
R15306	T28507	T28509	amod	defective,expression
R15307	T28337	T28333	pobj	],as
R15308	T28508	T28509	nummod	SOCS3,expression
R15309	T28509	T28497	conj	expression,responsiveness
R15310	T28338	T28317	punct	.,inhibits
R15311	T28510	T28511	aux	may,be
R15312	T28511	T28511	ROOT	be,be
R15313	T28512	T28511	acomp	responsible,be
R15314	T28339	T28343	nsubjpass	SOCS1,induced
R15315	T28513	T28512	prep	for,responsible
R15316	T28514	T28516	amod	persistent,activation
R15317	T28515	T28516	nummod	STAT3,activation
R15318	T28340	T28339	cc	and,SOCS1
R15319	T28516	T28513	pobj	activation,for
R15320	T28517	T28516	prep	in,activation
R15321	T28518	T28517	pobj	response,in
R15322	T28341	T28339	conj	SOCS3,SOCS1
R15323	T28519	T28520	aux	to,serum
R15324	T28520	T28516	relcl	serum,activation
R15325	T28521	T28520	dobj	IL-6,serum
R15326	T28522	T28511	punct	.,be
R15327	T28523	T28524	expl	There,is
R15328	T28536	T28535	prep	of,ability
R15329	T28524	T28524	ROOT	is,is
R15330	T28525	T28526	det	a,possibility
R15331	T28526	T28524	attr	possibility,is
R15332	T28537	T28540	nummod	CD4,cells
R15333	T28527	T28532	mark	that,associated
R15334	T28528	T28529	compound	SOCS1,induction
R15335	T28538	T28540	nummod	+,cells
R15336	T28529	T28532	nsubjpass	induction,associated
R15337	T28530	T28532	aux	may,associated
R15338	T28531	T28532	auxpass	be,associated
R15339	T28539	T28540	compound	T,cells
R15340	T28532	T28526	acl	associated,possibility
R15341	T28533	T28532	prep	with,associated
R15342	T28534	T28535	det	the,ability
R15343	T28535	T28533	pobj	ability,with
R15344	T28540	T28536	pobj	cells,of
R15345	T28541	T28542	aux	to,produce
R15346	T28542	T28535	acl	produce,ability
R15347	T28543	T28542	dobj	IFN-γ,produce
R15348	T28544	T28532	punct	",",associated
R15349	T28545	T28554	mark	because,produce
R15350	T28546	T28549	compound	CD4,cells
R15352	T28547	T28549	compound	+,cells
R15356	T28548	T28549	compound	T,cells
R15357	T28549	T28554	nsubj	cells,produce
R15360	T28550	T28549	prep	from,cells
R15362	T28551	T28552	amod	active,RA
R15365	T28552	T28550	pobj	RA,from
R15367	T28553	T28554	aux	could,produce
R15369	T28554	T28532	advcl	produce,associated
R15374	T28655	T28656	amod	high,levels
R15381	T28656	T28554	dobj	levels,produce
R15382	T28657	T28656	prep	of,levels
R15384	T28658	T28657	pobj	IFN-γ,of
R15388	T28659	T28554	prep	in,produce
R15391	T28660	T28661	det	the,presence
R15394	T28661	T28659	pobj	presence,in
R15396	T28662	T28661	prep	of,presence
R15401	T28663	T28662	pobj	IL-10,of
R15403	T28664	T28532	punct	",",associated
R15542	T28893	T28532	cc	and,associated
R15546	T28894	T28898	mark	because,known
R15548	T28895	T28898	nsubjpass	IFN-γ,known
R15550	T28896	T28898	aux	has,known
R15551	T28897	T28898	auxpass	been,known
R15552	T28898	T28524	advcl	known,is
R15554	T28899	T28898	prep	as,known
R15555	T28900	T28902	det	a,inducer
R15556	T28901	T28902	amod	potent,inducer
R15558	T28902	T28899	pobj	inducer,as
R15559	T28903	T28902	prep	of,inducer
R15560	T28904	T28907	nummod	SOCS1,]
R15561	T28914	T29178	det	this,regard
R15562	T28905	T28907	nmod	[,]
R15563	T28906	T28907	nummod	32,]
R15564	T28907	T28903	pobj	],of
R15565	T28908	T28524	punct	.,is
R15566	T28909	T28910	nsubj	It,is
R15568	T28910	T28910	ROOT	is,is
R15569	T28911	T28910	prep	of,is
R15570	T28912	T28911	pobj	interest,of
R15571	T28913	T28912	prep	in,interest
R15628	T29178	T28913	pobj	regard,in
R15629	T29179	T29180	aux	to,indicate
R15630	T29180	T28910	xcomp	indicate,is
R15631	T29181	T29187	mark	that,express
R15633	T29182	T29183	amod	polarized,Th1
R15636	T29183	T29186	nmod	Th1,cells
R15637	T29184	T29183	cc	and,Th1
R15638	T29185	T29183	conj	Th2,Th1
R15639	T29186	T29187	nsubj	cells,express
R15642	T29187	T29180	ccomp	express,indicate
R15643	T29188	T29189	amod	high,levels
R15644	T29189	T29187	dobj	levels,express
R15646	T29190	T29189	prep	of,levels
R15647	T29191	T29190	pobj	SOCS1,of
R15649	T29192	T29191	cc	and,SOCS1
R15651	T29193	T29194	nummod	SOCS3,mRNA
R15653	T29194	T29191	conj	mRNA,SOCS1
R15655	T29195	T29194	punct	",",mRNA
R15657	T29196	T29197	advmod	respectively,[
R15658	T29197	T29194	appos	[,mRNA
R15659	T29198	T29199	nummod	44,]
R15661	T29199	T29194	conj	],mRNA
R15662	T29200	T28910	punct	.,is
R15665	T29201	T29203	amod	IL-12-induced,activation
R15667	T29202	T29203	nummod	STAT4,activation
R15671	T29203	T29205	nsubjpass	activation,inhibited
R15674	T29204	T29205	auxpass	is,inhibited
R15675	T29205	T29205	ROOT	inhibited,inhibited
R15676	T29206	T29205	agent	by,inhibited
R15677	T29207	T29208	nummod	SOCS3,induction
R15678	T29208	T29206	pobj	induction,by
R15679	T29209	T29208	prep	in,induction
R15680	T29210	T29211	amod	Th2,cells
R15681	T29233	T29231	dobj	roles,have
R15682	T29211	T29209	pobj	cells,in
R15683	T29234	T29233	prep	as,roles
R15684	T29235	T29234	pcomp	Th1-specific,as
R15685	T29236	T29235	cc	and,Th1-specific
R15686	T29237	T29235	conj	Th2-specific,Th1-specific
R15687	T29238	T29243	punct	",",repressors
R15688	T29212	T29205	punct	",",inhibited
R15689	T29239	T29240	advmod	mutually,exclusive
R15690	T29240	T29243	amod	exclusive,repressors
R15691	T29241	T29243	punct	",",repressors
R15692	T29213	T29218	mark	whereas,diminished
R15693	T29242	T29243	amod	cross-talk,repressors
R15694	T29243	T29235	conj	repressors,Th1-specific
R15695	T29214	T29215	compound	IL-4-induced,STAT6
R15696	T29244	T29243	prep	of,repressors
R15697	T29245	T29246	det	the,IL-4
R15698	T29246	T29244	pobj	IL-4,of
R15699	T29215	T29218	nsubjpass	STAT6,diminished
R15700	T29247	T29243	appos	STAT6,repressors
R15701	T29248	T29247	cc	and,STAT6
R15702	T29249	T29250	det	the,IL-12
R15703	T29216	T29218	nsubjpass	signaling,diminished
R15704	T29250	T29247	conj	IL-12,STAT6
R15705	T29251	T29253	nummod	STAT4,pathways
R15706	T29252	T29253	compound	signaling,pathways
R15707	T29253	T29243	appos	pathways,repressors
R15708	T29217	T29218	auxpass	is,diminished
R15709	T29254	T29253	punct	",",pathways
R15710	T29255	T29253	advmod	respectively,pathways
R15711	T29256	T29243	punct	.,repressors
R15712	T29257	T29271	advcl	Consistent,express
R15713	T29218	T29205	advcl	diminished,inhibited
R15714	T29258	T29257	prep	with,Consistent
R15715	T29259	T29260	det	this,notion
R15716	T29219	T29218	agent	by,diminished
R15717	T29260	T29258	pobj	notion,with
R15718	T29261	T29271	punct	",",express
R15719	T29262	T29264	compound	PB,cells
R15720	T29220	T29221	nummod	SOCS1,induction
R15721	T29263	T29264	compound	T,cells
R15722	T29264	T29271	nsubj	cells,express
R15723	T29265	T29264	prep	from,cells
R15724	T29221	T29219	pobj	induction,by
R15725	T29266	T29265	pobj	patients,from
R15726	T29267	T29264	prep	with,cells
R15727	T29222	T29221	prep	in,induction
R15728	T29268	T29269	amod	allergic,diseases
R15729	T29269	T29267	pobj	diseases,with
R15730	T29270	T29271	advmod	significantly,express
R15731	T29223	T29224	amod	Th1,cells
R15732	T29271	T29271	ROOT	express,express
R15733	T29272	T29273	amod	high,levels
R15734	T29273	T29271	dobj	levels,express
R15735	T29274	T29273	prep	of,levels
R15736	T29275	T29276	nummod	SOCS3,transcripts
R15737	T29276	T29274	pobj	transcripts,of
R15738	T29224	T29222	pobj	cells,in
R15739	T29277	T29271	punct	",",express
R15740	T29278	T29271	cc	and,express
R15741	T29279	T29281	det	the,expression
R15742	T29225	T29205	punct	.,inhibited
R15743	T29280	T29281	compound	SOCS3,expression
R15744	T29281	T29282	nsubj	expression,correlates
R15745	T29282	T29271	conj	correlates,express
R15746	T29226	T29231	nsubj	SOCS1,have
R15747	T29283	T29282	advmod	well,correlates
R15748	T29284	T29282	prep	with,correlates
R15749	T29285	T29287	compound	serum,levels
R15750	T29227	T29226	cc	and,SOCS1
R15751	T29286	T29287	compound	IgE,levels
R15752	T29287	T29284	pobj	levels,with
R15753	T29288	T29287	cc	and,levels
R15754	T29228	T29226	conj	SOCS3,SOCS1
R15755	T29289	T29290	compound	disease,pathology
R15756	T29290	T29287	conj	pathology,levels
R15757	T29291	T29293	nmod	[,]
R15758	T29229	T29231	aux	may,have
R15759	T29292	T29293	nummod	45,]
R15760	T29293	T29290	appos	],pathology
R15761	T29230	T29231	advmod	thus,have
R15762	T29294	T29282	punct	.,correlates
R15763	T29231	T29231	ROOT	have,have
R15764	T29295	T29297	amod	Higher,expression
R15765	T29296	T29297	nummod	SOCS1,expression
R15766	T29232	T29233	amod	important,roles
R15767	T29297	T29317	dep	expression,is
R15768	T29298	T29297	prep	with,expression
R15770	T29299	T29301	amod	lower,expression
R15771	T29300	T29301	amod	SOCS3,expression
R15772	T29301	T29298	pobj	expression,with
R15773	T29302	T29301	prep	in,expression
R15774	T29303	T29304	compound	PB,CD4
R15775	T29304	T29302	pobj	CD4,in
R15776	T29305	T29307	amod	+,cells
R15778	T29306	T29307	compound	T,cells
R15779	T29307	T29297	conj	cells,expression
R15780	T29308	T29307	prep	from,cells
R15782	T29309	T29310	compound	RA,patients
R15783	T29310	T29308	pobj	patients,from
R15784	T29311	T29297	punct	",",expression
R15785	T29312	T29297	prep	compared,expression
R15786	T29313	T29312	prep	with,compared
R15787	T29314	T29315	amod	healthy,controls
R15789	T29315	T29313	pobj	controls,with
R15790	T29316	T29317	punct	",",is
R15791	T29317	T29317	ROOT	is,is
R15792	T29318	T29317	advmod	therefore,is
R15794	T29319	T29320	advmod	probably,consistent
R15795	T29320	T29317	acomp	consistent,is
R15796	T29321	T29320	prep	with,consistent
R15797	T29322	T29324	poss	their,bias
R15798	T29323	T29324	amod	systemic,bias
R15799	T29324	T29321	pobj	bias,with
R15800	T29325	T29324	prep	towards,bias
R15801	T29326	T29328	det	a,phenotype
R15802	T29327	T29328	amod	Th1,phenotype
R15803	T29328	T29325	pobj	phenotype,towards
R15805	T29329	T29317	punct	",",is
R15806	T29330	T29334	mark	as,demonstrated
R15807	T29331	T29334	aux	has,demonstrated
R15808	T29332	T29334	advmod	previously,demonstrated
R15810	T29333	T29334	auxpass	been,demonstrated
R15811	T29334	T29317	advcl	demonstrated,is
R15812	T29335	T29337	compound	[,]
R15814	T29336	T29337	compound	46-49,]
R15815	T29337	T29334	dobj	],demonstrated
R15816	T29338	T29317	punct	.,is
R13901	T27096	T27097	nummod	STAT1,phosphorylation
R13902	T27097	T27108	nsubj	phosphorylation,induces
R13904	T27098	T27097	prep	in,phosphorylation
R13905	T27099	T27103	amod	normal,cells
R13906	T27100	T27103	compound	CD4,cells
R13907	T27101	T27103	nummod	+,cells
R13910	T27102	T27103	compound	T,cells
R13912	T27103	T27098	pobj	cells,in
R13914	T27104	T27097	punct	",",phosphorylation
R13915	T27105	T27097	cc	and,phosphorylation
R13916	T27106	T27107	amod	exogenous,IL-6
R13917	T27107	T27097	conj	IL-6,phosphorylation
R13919	T27108	T27092	conj	induces,induces
R13920	T27109	T27110	det	the,resistance
R13921	T27110	T27108	dobj	resistance,induces
R13922	T27111	T27110	prep	to,resistance
R13923	T27112	T27113	compound	IL-10,inhibition
R13924	T27113	T27111	pobj	inhibition,to
R13926	T27114	T27113	prep	of,inhibition
R13927	T27115	T27116	amod	IFN-γ,production
R13928	T27116	T27114	pobj	production,of
R13930	T27117	T27108	punct	.,induces
R13931	T27118	T27119	compound	RA,CD4
R13932	T27119	T27122	compound	CD4,cells
R13934	T27120	T27122	amod	+,cells
R13935	T27121	T27122	compound	T,cells
R13937	T27122	T27123	nsubj	cells,contain
R13938	T27123	T27123	ROOT	contain,contain
R13939	T27124	T27125	amod	higher,levels
R13941	T27125	T27123	dobj	levels,contain
R13942	T27126	T27125	prep	of,levels
R13943	T27127	T27126	pobj	SOCS1,of
R13945	T27128	T27123	cc	but,contain
R13946	T27129	T27123	conj	contain,contain
R13947	T27130	T27131	amod	lower,levels
R13949	T27131	T27129	dobj	levels,contain
R13950	T27132	T27131	prep	of,levels
R13951	T27133	T27134	nummod	SOCS3,transcripts
R13900	T27182	T27181	pobj	association,in
R13903	T27183	T27182	prep	with,association
R13908	T27184	T27186	amod	sustained,phosphorylation
R13909	T27185	T27186	compound	STAT3,phosphorylation
R13911	T27186	T27183	pobj	phosphorylation,with
R13913	T27187	T27186	cc	and,phosphorylation
R13918	T27188	T27189	nummod	SOCS1,induction
R13925	T27189	T27186	conj	induction,phosphorylation
R13929	T27190	T27146	punct	.,indicate
R13933	T27191	T27192	amod	IL-10-mediated,inhibition
R13978	T27203	T27204	poss	its,inhibition
R13982	T27204	T27202	pobj	inhibition,on
R13986	T27205	T27204	prep	of,inhibition
R13990	T27206	T27209	nmod	macrophage,function
R13994	T27207	T27209	amod	antigen-presenting,function
R13998	T27208	T27209	compound	cell,function
R14001	T27209	T27205	pobj	function,of
R14006	T27210	T27212	nmod	[,]
R14010	T27211	T27212	nummod	1,]
R14013	T27212	T27204	appos	],inhibition
R14017	T27213	T27199	punct	.,is
R14018	T27214	T27221	advmod	However,thought
R14019	T27215	T27221	punct	",",thought
R14023	T27216	T27219	det	this,effect
R14026	T27217	T27219	amod	indirect,effect
R14031	T27218	T27219	amod	inhibitory,effect
R14034	T27219	T27221	nsubjpass	effect,thought
R14036	T27220	T27221	auxpass	is,thought
R14037	T27221	T27221	ROOT	thought,thought
R14038	T27222	T27224	aux	to,restricted
R14165	T27380	T27373	punct	.,seems
R14166	T27381	T27382	det	The,activation
R14168	T27382	T27400	nsubj	activation,inhibits
R14169	T27383	T27382	prep	of,activation
R14171	T27384	T27388	preconj	both,kinase
R14172	T27385	T27388	det	the,kinase
R14173	T27386	T27388	amod	extracellular,kinase
R14174	T27387	T27388	amod	stimulus-regulated,kinase
R14175	T27388	T27383	pobj	kinase,of
R14177	T27389	T27388	cc	and,kinase
R14178	T27390	T27392	amod	p38,pathways
R14179	T27391	T27392	compound	kinase,pathways
R14181	T27392	T27388	conj	pathways,kinase
R14182	T27393	T27392	punct	",",pathways
R14183	T27394	T27392	acl	induced,pathways
R14185	T27395	T27394	agent	by,induced
R14189	T27396	T27395	pobj	TNF-α,by
R14190	T27397	T27396	cc	and,TNF-α
R14192	T27398	T27396	conj	IL-1,TNF-α
R14193	T27399	T27400	punct	",",inhibits
R14194	T27400	T27400	ROOT	inhibits,inhibits
R14196	T27401	T27402	det	the,Jak1
R14197	T27402	T27400	dobj	Jak1,inhibits
R14198	T27403	T27405	nummod	STAT3,pathway
R14200	T27404	T27405	amod	signaling,pathway
R14201	T27405	T27402	appos	pathway,Jak1
R14203	T27406	T27405	acl	shared,pathway
R14204	T27407	T27406	agent	by,shared
R14205	T27408	T27407	pobj	IL-10,by
R14265	T27451	T27452	compound	surface,IL-10R1
R14266	T27452	T27453	compound	IL-10R1,expression
R14268	T27453	T27459	nsubjpass	expression,suppressed
R14269	T27454	T27453	cc	and,expression
R14270	T27455	T27457	amod	IL-10-induced,activation
R14233	T27472	T27479	det	the,]
R14236	T27473	T27474	compound	IgG,Fc
R14240	T27474	T27479	compound	Fc,]
R14244	T27475	T27476	compound	gamma,receptor
R14248	T27476	T27479	compound	receptor,]
R14252	T27477	T27479	nmod	[,]
R14255	T27478	T27479	nummod	14,]
R14260	T27479	T27471	pobj	],of

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T24231	10930-10935	Positive_regulation	denotes	lower
T24230	10942-10952	Gene_expression	denotes	expression
T24229	10914-10924	Gene_expression	denotes	expression
T24228	10956-10962	Protein	denotes	PB CD4
T24227	10936-10941	Protein	denotes	SOCS3
T24226	10908-10913	Protein	denotes	SOCS1
T24225	10824-10834	Gene_expression	denotes	expression
T24224	10768-10775	Gene_expression	denotes	express
T24223	10862-10865	Protein	denotes	IgE
T24222	10818-10823	Protein	denotes	SOCS3
T24221	10791-10808	Protein	denotes	SOCS3 transcripts
T24220	10637-10642	Protein	denotes	STAT4
T24219	10631-10636	Protein	denotes	IL-12
T24218	10617-10622	Protein	denotes	STAT6
T24217	10612-10616	Protein	denotes	IL-4
T24216	10532-10535	Protein	denotes	Th1
T24215	10493-10498	Protein	denotes	SOCS3
T24214	10483-10488	Protein	denotes	SOCS1
T24213	10459-10468	Positive_regulation	denotes	induction
T24212	10375-10384	Positive_regulation	denotes	induction
T24211	10356-10365	Negative_regulation	denotes	inhibited
T24210	10342-10352	Positive_regulation	denotes	activation
T24209	10453-10458	Protein	denotes	SOCS1
T24208	10420-10425	Protein	denotes	STAT6
T24207	10407-10411	Protein	denotes	IL-4
T24206	10369-10374	Protein	denotes	SOCS3
T24205	10336-10341	Protein	denotes	STAT4
T24204	10271-10277	Positive_regulation	denotes	levels
T24203	10271-10277	Positive_regulation	denotes	levels
T24202	10258-10265	Gene_expression	denotes	express
T24201	10258-10265	Gene_expression	denotes	express
T24200	10291-10301	Protein	denotes	SOCS3 mRNA
T24199	10281-10286	Protein	denotes	SOCS1
T24198	10240-10243	Protein	denotes	Th1
T24197	10057-10064	Gene_expression	denotes	produce
T24196	10000-10007	Gene_expression	denotes	produce
T24195	9936-9945	Positive_regulation	denotes	induction
T24194	10124-10129	Protein	denotes	IFN-γ
T24193	10080-10085	Protein	denotes	IFN-γ
T24192	10023-10027	Protein	denotes	CD4+
T24191	10008-10013	Protein	denotes	IFN-γ
T24190	9984-9988	Protein	denotes	CD4+
T24189	9930-9935	Protein	denotes	SOCS1
T24188	9797-9806	Negative_regulation	denotes	defective
T24187	9766-9774	Positive_regulation	denotes	mediated
T24186	9632-9641	Positive_regulation	denotes	Increased
T24185	9864-9874	Positive_regulation	denotes	activation
T24184	9813-9823	Gene_expression	denotes	expression
T24183	9781-9791	Positive_regulation	denotes	activation
T24182	9648-9658	Gene_expression	denotes	expression
T24181	9890-9900	Protein	denotes	serum IL-6
T24180	9858-9863	Protein	denotes	STAT3
T24179	9807-9812	Protein	denotes	SOCS3
T24178	9775-9780	Protein	denotes	STAT3
T24177	9760-9765	Protein	denotes	IL-10
T24176	9747-9752	Protein	denotes	IL-10
T24175	9662-9669	Protein	denotes	RA CD4+
T24174	9642-9647	Protein	denotes	SOCS1
T24173	9601-9606	Protein	denotes	IL-10
T24172	9565-9570	Protein	denotes	SOCS1
T24171	9521-9526	Protein	denotes	IL-10
T24170	9423-9428	Protein	denotes	SOCS3
T24169	9293-9302	Negative_regulation	denotes	deficient
T24168	9370-9374	Protein	denotes	IL-6
T24167	9334-9339	Protein	denotes	SOCS3
T24166	9287-9292	Protein	denotes	SOCS3
T24165	9164-9174	Negative_regulation	denotes	deficiency
T24164	9223-9233	Positive_regulation	denotes	activation
T24163	9190-9200	Negative_regulation	denotes	deficiency
T24162	9164-9174	Negative_regulation	denotes	deficiency
T24161	9127-9136	Negative_regulation	denotes	deficient
T24160	9237-9242	Protein	denotes	STAT3
T24159	9184-9189	Protein	denotes	SOCS1
T24158	9158-9163	Protein	denotes	SOCS3
T24157	9121-9126	Protein	denotes	SOCS3
T24156	8985-8992	Negative_regulation	denotes	lacking
T24155	8985-8992	Negative_regulation	denotes	lacking
T24154	9081-9086	Protein	denotes	IL-10
T24153	9055-9059	Protein	denotes	IL-6
T24152	9022-9027	Protein	denotes	SOCS3
T24151	9002-9007	Protein	denotes	SOCS1
T24150	8993-8998	Protein	denotes	SOCS3
T24149	8840-8847	Positive_regulation	denotes	induced
T24148	8840-8847	Positive_regulation	denotes	induced
T24147	8840-8847	Positive_regulation	denotes	induced
T24146	8840-8847	Positive_regulation	denotes	induced
T24145	8840-8847	Positive_regulation	denotes	induced
T24144	8840-8847	Positive_regulation	denotes	induced
T24143	8889-8894	Protein	denotes	IL-10
T24142	8880-8884	Protein	denotes	IL-6
T24141	8830-8835	Protein	denotes	SOCS3
T24140	8820-8825	Protein	denotes	SOCS1
T24139	8635-8643	Negative_regulation	denotes	prevents
T24138	8730-8737	Binding	denotes	binding
T24137	8674-8681	Binding	denotes	binding
T24136	8644-8654	Positive_regulation	denotes	activation
T24135	8808-8813	Protein	denotes	gp130
T24134	8745-8799	Protein	denotes	Src homology phosphatase-2-binding domain of receptors
T24133	8723-8726	Protein	denotes	JAK
T24132	8694-8699	Protein	denotes	SOCS3
T24131	8685-8688	Protein	denotes	JAK
T24130	8658-8661	Protein	denotes	JAK
T24129	8629-8634	Protein	denotes	SOCS1
T24128	8577-8583	Positive_regulation	denotes	levels
T24127	8550-8556	Positive_regulation	denotes	levels
T24126	8615-8619	Protein	denotes	CD4+
T24125	8587-8592	Protein	denotes	SOCS3
T24124	8560-8565	Protein	denotes	SOCS1
T24123	8491-8495	Protein	denotes	CD4+
T24122	8451-8462	Protein	denotes	SOCS family
T24121	8418-8422	Protein	denotes	STAT
T24120	8414-8417	Protein	denotes	JAK
T24119	8335-8343	Positive_regulation	denotes	mediated
T24118	8350-8360	Positive_regulation	denotes	activation
T24117	8344-8349	Protein	denotes	STAT3
T24116	8329-8334	Protein	denotes	gp130
T24115	8228-8232	Protein	denotes	CD4+
T24114	8143-8150	Positive_regulation	denotes	mutated
T24113	8143-8150	Positive_regulation	denotes	mutated
T24112	8093-8122	Protein	denotes	IL-6 family cytokine receptor
T24060	5747-5751	Protein	denotes	CD4+
T24071	6178-6182	Protein	denotes	IL-6
T24070	6104-6109	Protein	denotes	IL-10
T24069	6088-6092	Protein	denotes	CD4+
T24068	5992-5998	Negative_regulation	denotes	defect
T24067	6020-6025	Protein	denotes	STAT3
T24066	5938-5942	Protein	denotes	CD4+
T24065	5779-5788	Localization	denotes	secretion
T24064	5779-5788	Localization	denotes	secretion
T24063	5736-5743	Positive_regulation	denotes	induced
T24062	5853-5859	Protein	denotes	RA CD4
T24061	5773-5778	Protein	denotes	IL-10
T24059	5697-5702	Protein	denotes	STAT3
T24058	5586-5593	Positive_regulation	denotes	induced
T24057	5488-5497	Positive_regulation	denotes	sustained
T24056	5633-5647	Positive_regulation	denotes	concentrations
T24055	5586-5593	Positive_regulation	denotes	induced
T24054	5543-5553	Negative_regulation	denotes	inhibition
T24053	5504-5514	Positive_regulation	denotes	activation
T24052	5651-5661	Protein	denotes	serum IL-6
T24051	5563-5572	Protein	denotes	RA CD4+ T
T24050	5537-5542	Protein	denotes	IL-10
T24049	5498-5503	Protein	denotes	STAT3
T24048	5446-5450	Protein	denotes	IL-6
T24047	5399-5403	Protein	denotes	CD4+
T24046	5368-5373	Protein	denotes	IL-10
T24045	5272-5295	Protein	denotes	STAT3-activating factor
T24044	5253-5257	Protein	denotes	IL-6
T24043	4850-4859	Positive_regulation	denotes	activated
T24042	4975-4987	Protein	denotes	oncostatin M
T24041	4936-4941	Protein	denotes	IL-11
T24040	4930-4934	Protein	denotes	IL-6
T24039	4899-4910	Protein	denotes	IL-6 family
T24038	4841-4846	Protein	denotes	STAT3
T24037	4678-4686	Positive_regulation	denotes	mediated
T24036	4736-4750	Phosphorylation	denotes	phosphorylated
T24035	4693-4703	Positive_regulation	denotes	activation
T24034	4810-4813	Protein	denotes	CD4
T24033	4705-4710	Protein	denotes	STAT3
T24032	4687-4692	Protein	denotes	STAT3
T24031	4672-4677	Protein	denotes	IL-10
T24030	4423-4433	Positive_regulation	denotes	activation
T24029	4456-4466	Gene_expression	denotes	expression
T24028	4423-4433	Positive_regulation	denotes	activation
T24027	4448-4455	Protein	denotes	IL-10R1
T24026	4417-4422	Protein	denotes	STAT3
T24025	4401-4406	Protein	denotes	IL-10
T24024	4362-4367	Protein	denotes	IL-10
T24023	4343-4349	Protein	denotes	RA CD4
T24022	4234-4238	Protein	denotes	IL-1
T24021	4227-4232	Protein	denotes	TNF-α
T24020	4145-4166	Protein	denotes	intracellular IL-10R1
T24019	4109-4114	Protein	denotes	IL-10
T24018	3964-3972	Binding	denotes	ligation
T24017	3980-4001	Protein	denotes	IgG Fc gamma receptor
T24016	3919-3935	Protein	denotes	protein kinase C
T24015	3889-3894	Protein	denotes	IFN-γ
T24014	3855-3859	Protein	denotes	Jak1
T24013	3841-3846	Protein	denotes	IL-10
T24012	3707-3712	Protein	denotes	IL-10
T24011	3616-3624	Positive_regulation	denotes	mediated
T24001	3480-3485	Protein	denotes	TNF-α
T24000	3448-3458	Protein	denotes	p38 kinase
T23999	3184-3192	Gene_expression	denotes	produced
T23998	3177-3182	Protein	denotes	IL-10
T23997	2926-2938	Positive_regulation	denotes	costimulated
T23996	2926-2938	Positive_regulation	denotes	costimulated
T23995	2907-2917	Negative_regulation	denotes	inhibition
T23994	2907-2917	Negative_regulation	denotes	inhibition
T23993	2939-2949	Gene_expression	denotes	production
T23992	2939-2949	Gene_expression	denotes	production
T23991	2968-2972	Protein	denotes	IL-2
T23990	2958-2963	Protein	denotes	IFN-γ
T23989	2921-2925	Protein	denotes	CD28
T23988	2901-2906	Protein	denotes	IL-10
T23987	2869-2873	Protein	denotes	CD4+
T23986	2743-2753	Negative_regulation	denotes	inhibiting
T23985	2768-2783	Phosphorylation	denotes	phosphorylation
T23984	2759-2767	Entity	denotes	tyrosine
T23983	2754-2758	Protein	denotes	CD28
T23982	2664-2669	Protein	denotes	IL-10
T23981	2552-2559	Gene_expression	denotes	express
T23980	2552-2559	Gene_expression	denotes	express
T23979	2552-2559	Gene_expression	denotes	express
T23978	2615-2636	Protein	denotes	MHC class II antigens
T23977	2595-2609	Protein	denotes	CD86 molecules
T23976	2586-2590	Protein	denotes	CD80
T23975	2286-2289	Protein	denotes	CD4
T23974	2257-2262	Protein	denotes	IL-10
T23973	2246-2255	Positive_regulation	denotes	induction
T23972	2246-2255	Positive_regulation	denotes	induction
T23971	2220-2235	Phosphorylation	denotes	phosphorylation
T23970	2240-2245	Protein	denotes	SOCS1
T23969	2214-2219	Protein	denotes	STAT3
T23968	2166-2171	Protein	denotes	STAT3
T23967	2150-2155	Protein	denotes	IL-10
T23966	1982-1986	Protein	denotes	CD4+
T23965	1885-1891	Positive_regulation	denotes	levels
T23964	1851-1857	Positive_regulation	denotes	levels
T23963	1939-1943	Protein	denotes	CD4+
T23962	1895-1912	Protein	denotes	SOCS3 transcripts
T23961	1861-1866	Protein	denotes	SOCS1
T23960	1823-1827	Protein	denotes	CD4+
T23959	1756-1763	Positive_regulation	denotes	induces
T23958	1768-1778	Positive_regulation	denotes	resistance
T23957	1788-1798	Negative_regulation	denotes	inhibition
T23956	1669-1676	Positive_regulation	denotes	induces
T23955	1669-1676	Positive_regulation	denotes	induces
T23954	1808-1818	Gene_expression	denotes	production
T23953	1697-1712	Phosphorylation	denotes	phosphorylation
T23952	1697-1712	Phosphorylation	denotes	phosphorylation
T23951	1802-1807	Protein	denotes	IFN-γ
T23950	1782-1787	Protein	denotes	IL-10
T23949	1751-1755	Protein	denotes	IL-6
T23948	1723-1727	Protein	denotes	CD4+
T23947	1691-1696	Protein	denotes	STAT1
T23946	1677-1682	Protein	denotes	STAT3
T23945	1390-1400	Positive_regulation	denotes	high-level
T23944	1621-1630	Positive_regulation	denotes	inducible
T23943	1585-1600	Phosphorylation	denotes	phosphorylation
T23942	1506-1516	Negative_regulation	denotes	suppressed
T23941	1478-1493	Phosphorylation	denotes	phosphorylation
T23940	1469-1477	Entity	denotes	tyrosine
T23939	1443-1453	Positive_regulation	denotes	activation
T23938	1409-1419	Gene_expression	denotes	expression
T23937	1634-1639	Protein	denotes	IL-10
T23936	1579-1584	Protein	denotes	STAT3
T23935	1559-1562	Protein	denotes	CD4
T23934	1520-1526	Protein	denotes	RA CD4
T23933	1497-1502	Protein	denotes	STAT3
T23932	1437-1442	Protein	denotes	STAT3
T23931	1401-1408	Protein	denotes	IL-10R1
T23930	1292-1299	Gene_expression	denotes	produce
T23929	1292-1299	Gene_expression	denotes	produce
T23928	1368-1372	Protein	denotes	CD4+
T23927	1337-1341	Protein	denotes	CD28
T23926	1329-1332	Protein	denotes	CD3
T23925	1317-1322	Protein	denotes	IFN-γ
T24111	8038-8043	Protein	denotes	gp130
T24110	7995-8034	Protein	denotes	Src homology phosphatase-2 binding site
T24109	7865-7870	Protein	denotes	STAT3
T24108	7719-7724	Protein	denotes	STAT3
T24107	7599-7609	Positive_regulation	denotes	activation
T24106	7504-7513	Positive_regulation	denotes	activated
T24105	7593-7598	Protein	denotes	STAT3
T24104	7553-7557	Protein	denotes	IL-6
T24103	7514-7519	Protein	denotes	STAT3
T24102	7398-7408	Gene_expression	denotes	expression
T24101	7416-7440	Protein	denotes	Fc gamma receptor type I
T24100	7269-7274	Protein	denotes	STAT3
T24099	7251-7255	Protein	denotes	IL-6
T24098	7182-7191	Gene_expression	denotes	expressed
T24097	7158-7163	Protein	denotes	STAT3
T24096	7093-7103	Positive_regulation	denotes	activation
T24095	7087-7092	Protein	denotes	STAT3
T24094	6928-6933	Protein	denotes	IL-10
T24093	6784-6793	Positive_regulation	denotes	stimulate
T24092	6825-6831	Positive_regulation	denotes	induce
T24091	6800-6810	Positive_regulation	denotes	activation
T24090	6874-6879	Protein	denotes	IL-10
T24089	6832-6845	Protein	denotes	SOCS1 protein
T24088	6815-6820	Protein	denotes	IFN-γ
T24087	6794-6799	Protein	denotes	STAT3
T24086	6761-6766	Protein	denotes	IL-10
T24085	6704-6711	Gene_expression	denotes	produce
T24084	6704-6711	Gene_expression	denotes	produce
T24083	6580-6588	Gene_expression	denotes	produced
T24082	6580-6588	Gene_expression	denotes	produced
T24081	6650-6655	Protein	denotes	IL-10
T24080	6592-6596	Protein	denotes	CD4+
T24079	6574-6579	Protein	denotes	IL-10
T24078	6564-6569	Protein	denotes	IFN-γ
T24077	6487-6492	Protein	denotes	TNF-α
T24076	6477-6482	Protein	denotes	IL-1β
T24075	6431-6435	Protein	denotes	CD4+
T24074	6411-6416	Protein	denotes	IFN-γ
T24073	6396-6401	Protein	denotes	IL-10
T24072	6122-6131	Positive_regulation	denotes	augmented
T23920	1014-1022	Entity	denotes	tyrosine
T23919	1046-1059	Protein	denotes	CD28 molecule
T23918	995-1000	Protein	denotes	IL-10
T23917	827-830	Protein	denotes	IgG
T23916	661-676	Protein	denotes	CD28 engagement
T23915	554-563	Gene_expression	denotes	expressed
T23914	554-563	Gene_expression	denotes	expressed
T23913	554-563	Gene_expression	denotes	expressed
T23912	554-563	Gene_expression	denotes	expressed
T23911	513-534	Protein	denotes	MHC class II antigens
T23910	493-497	Protein	denotes	CD86
T23909	484-488	Protein	denotes	CD80
T23908	465-477	Protein	denotes	CD28 ligands
T23907	414-418	Protein	denotes	CD28
T23906	333-337	Protein	denotes	CD4+
T23905	101-105	Protein	denotes	CD4+
T23904	11-15	Protein	denotes	CD4+
T23924	1273-1278	Protein	denotes	IL-10
T23923	1211-1214	Protein	denotes	CD4
T23922	1001-1009	Negative_regulation	denotes	inhibits
T23921	1023-1038	Phosphorylation	denotes	phosphorylation
T24010	3631-3641	Positive_regulation	denotes	activation
T24009	3625-3630	Protein	denotes	STAT3
T24008	3610-3615	Protein	denotes	IL-10
T24007	3496-3504	Negative_regulation	denotes	inhibits
T24006	3558-3562	Protein	denotes	IL-6
T24005	3548-3553	Protein	denotes	IL-10
T24004	3514-3519	Protein	denotes	STAT3
T24003	3509-3513	Protein	denotes	Jak1
T24002	3490-3494	Protein	denotes	IL-1
R11428	T23961	T23964	themeOf	SOCS1,levels
R11429	T23962	T23965	themeOf	SOCS3 transcripts,levels
R11430	T23969	T23971	themeOf	STAT3,phosphorylation
R11436	T23982	T23986	causeOf	IL-10,inhibiting
R11398	T23908	T23912	themeOf	CD28 ligands,expressed
R11399	T23909	T23913	themeOf	CD80,expressed
R11400	T23910	T23914	themeOf	CD86,expressed
R11401	T23911	T23915	themeOf	MHC class II antigens,expressed
R11402	T23918	T23922	causeOf	IL-10,inhibits
R11403	T23919	T23921	themeOf	CD28 molecule,phosphorylation
R11404	T23919	T23920	partOf	CD28 molecule,tyrosine
R11405	T23920	T23921	Site	tyrosine,phosphorylation
R11406	T23921	T23922	themeOf	phosphorylation,inhibits
R11407	T23925	T23929	themeOf	IFN-γ,produce
R11408	T23926	T23930	themeOf	CD3,produce
R11409	T23931	T23938	themeOf	IL-10R1,expression
R11410	T23932	T23939	themeOf	STAT3,activation
R11411	T23933	T23941	themeOf	STAT3,phosphorylation
R11412	T23933	T23940	partOf	STAT3,tyrosine
R11413	T23936	T23943	themeOf	STAT3,phosphorylation
R11414	T23937	T23944	causeOf	IL-10,inducible
R11415	T23938	T23945	themeOf	expression,high-level
R11416	T23940	T23941	Site	tyrosine,phosphorylation
R11417	T23941	T23942	themeOf	phosphorylation,suppressed
R11418	T23943	T23944	themeOf	phosphorylation,inducible
R11419	T23946	T23952	themeOf	STAT3,phosphorylation
R11420	T23947	T23953	themeOf	STAT1,phosphorylation
R11421	T23949	T23959	causeOf	IL-6,induces
R11422	T23951	T23954	themeOf	IFN-γ,production
R11423	T23952	T23955	themeOf	phosphorylation,induces
R11424	T23953	T23956	themeOf	phosphorylation,induces
R11425	T23954	T23957	themeOf	production,inhibition
R11426	T23957	T23958	themeOf	inhibition,resistance
R11427	T23958	T23959	themeOf	resistance,induces
R11437	T23983	T23985	themeOf	CD28,phosphorylation
R11438	T23983	T23984	partOf	CD28,tyrosine
R11439	T23984	T23985	Site	tyrosine,phosphorylation
R11440	T23985	T23986	themeOf	phosphorylation,inhibiting
R11441	T23989	T23996	causeOf	CD28,costimulated
R11442	T23989	T23997	causeOf	CD28,costimulated
R11443	T23990	T23992	themeOf	IFN-γ,production
R11444	T23991	T23993	themeOf	IL-2,production
R11445	T23992	T23994	themeOf	production,inhibition
R11446	T23992	T23996	themeOf	production,costimulated
R11447	T23993	T23995	themeOf	production,inhibition
R11448	T23993	T23997	themeOf	production,costimulated
R11449	T23998	T23999	themeOf	IL-10,produced
R11450	T24004	T24007	themeOf	STAT3,inhibits
R11451	T24008	T24011	causeOf	IL-10,mediated
R11452	T24009	T24010	themeOf	STAT3,activation
R11453	T24010	T24011	themeOf	activation,mediated
R11454	T24017	T24018	themeOf	IgG Fc gamma receptor,ligation
R11455	T24026	T24028	themeOf	STAT3,activation
R11456	T24027	T24029	themeOf	IL-10R1,expression
R11457	T24029	T24030	themeOf	expression,activation
R11458	T24031	T24037	causeOf	IL-10,mediated
R11459	T24032	T24035	themeOf	STAT3,activation
R11460	T24033	T24036	themeOf	STAT3,phosphorylated
R11461	T24035	T24037	themeOf	activation,mediated
R11462	T24038	T24043	themeOf	STAT3,activated
R11463	T24049	T24053	themeOf	STAT3,activation
R11464	T24050	T24054	themeOf	IL-10,inhibition
R11465	T24052	T24056	themeOf	serum IL-6,concentrations
R11466	T24053	T24055	themeOf	activation,induced
R11467	T24053	T24057	themeOf	activation,sustained
R11468	T24056	T24058	themeOf	concentrations,induced
R11469	T24059	T24063	themeOf	STAT3,induced
R11470	T24059	T24064	themeOf	STAT3,secretion
R11471	T24061	T24065	themeOf	IL-10,secretion
R11472	T24067	T24068	themeOf	STAT3,defect
R11473	T24070	T24072	themeOf	IL-10,augmented
R11474	T24078	T24082	themeOf	IFN-γ,produced
R11475	T24078	T24084	themeOf	IFN-γ,produce
R11476	T24079	T24083	themeOf	IL-10,produced
R11477	T24079	T24085	themeOf	IL-10,produce
R11478	T24086	T24093	causeOf	IL-10,stimulate
R11479	T24087	T24091	themeOf	STAT3,activation
R11480	T24088	T24092	causeOf	IFN-γ,induce
R11481	T24089	T24092	themeOf	SOCS1 protein,induce
R11482	T24091	T24093	themeOf	activation,stimulate
R11483	T24095	T24096	themeOf	STAT3,activation
R11484	T24097	T24098	themeOf	STAT3,expressed
R11485	T24101	T24102	themeOf	Fc gamma receptor type I,expression
R11486	T24103	T24106	themeOf	STAT3,activated
R11487	T24105	T24107	themeOf	STAT3,activation
R11488	T24110	T24113	themeOf	Src homology phosphatase-2 binding site,mutated
R11489	T24111	T24114	themeOf	gp130,mutated
R11490	T24116	T24119	causeOf	gp130,mediated
R11491	T24117	T24118	themeOf	STAT3,activation
R11492	T24118	T24119	themeOf	activation,mediated
R11493	T24124	T24127	themeOf	SOCS1,levels
R11494	T24125	T24128	themeOf	SOCS3,levels
R11495	T24130	T24136	themeOf	JAK,activation
R11496	T24131	T24137	themeOf	JAK,binding
R11497	T24134	T24138	themeOf	Src homology phosphatase-2-binding domain of receptors,binding
R11498	T24136	T24139	themeOf	activation,prevents
R11499	T24137	T24139	causeOf	binding,prevents
R11500	T24140	T24144	themeOf	SOCS1,induced
R11501	T24140	T24146	themeOf	SOCS1,induced
R11502	T24140	T24148	themeOf	SOCS1,induced
R11503	T24141	T24145	themeOf	SOCS3,induced
R11504	T24141	T24147	themeOf	SOCS3,induced
R11505	T24141	T24149	themeOf	SOCS3,induced
R11506	T24142	T24146	causeOf	IL-6,induced
R11507	T24142	T24147	causeOf	IL-6,induced
R11508	T24143	T24148	causeOf	IL-10,induced
R11509	T24143	T24149	causeOf	IL-10,induced
R11510	T24150	T24155	themeOf	SOCS3,lacking
R11511	T24151	T24156	themeOf	SOCS1,lacking
R11512	T24157	T24161	themeOf	SOCS3,deficient
R11513	T24158	T24162	themeOf	SOCS3,deficiency
R11514	T24159	T24163	themeOf	SOCS1,deficiency
R11515	T24160	T24164	themeOf	STAT3,activation
R11516	T24163	T24165	themeOf	deficiency,deficiency
R11517	T24166	T24169	themeOf	SOCS3,deficient
R11518	T24174	T24182	themeOf	SOCS1,expression
R11519	T24177	T24187	causeOf	IL-10,mediated
R11520	T24178	T24183	themeOf	STAT3,activation
R11521	T24179	T24184	themeOf	SOCS3,expression
R11522	T24180	T24185	themeOf	STAT3,activation
R11523	T24182	T24186	themeOf	expression,Increased
R11524	T24183	T24187	themeOf	activation,mediated
R11525	T24184	T24188	themeOf	expression,defective
R11526	T24189	T24195	themeOf	SOCS1,induction
R11527	T24191	T24196	themeOf	IFN-γ,produce
R11528	T24193	T24197	themeOf	IFN-γ,produce
R11529	T24199	T24201	themeOf	SOCS1,express
R11530	T24199	T24203	themeOf	SOCS1,levels
R11531	T24200	T24202	themeOf	SOCS3 mRNA,express
R11532	T24200	T24204	themeOf	SOCS3 mRNA,levels
R11533	T24205	T24210	themeOf	STAT4,activation
R11534	T24206	T24212	themeOf	SOCS3,induction
R11535	T24209	T24213	themeOf	SOCS1,induction
R11536	T24210	T24211	themeOf	activation,inhibited
R11537	T24221	T24224	themeOf	SOCS3 transcripts,express
R11538	T24222	T24225	themeOf	SOCS3,expression
R11539	T24226	T24229	themeOf	SOCS1,expression
R11540	T24227	T24230	themeOf	SOCS3,expression
R11541	T24230	T24231	themeOf	expression,lower
R11431	T23970	T23972	themeOf	SOCS1,induction
R11432	T23971	T23973	themeOf	phosphorylation,induction
R11433	T23976	T23979	themeOf	CD80,express
R11434	T23977	T23980	themeOf	CD86 molecules,express
R11435	T23978	T23981	themeOf	MHC class II antigens,express

test3

Id	Subject	Object	Predicate	Lexical cue
T22614	5498-5503	Protein	denotes	STAT3
T22750	9930-9935	Protein	denotes	SOCS1
T22787	10959-10962	Protein	denotes	CD4
T22786	10942-10952	Gene_expression	denotes	expression
T22785	10936-10941	Protein	denotes	SOCS3
T22784	10908-10913	Protein	denotes	SOCS1
T22783	10818-10823	Protein	denotes	SOCS3
T22782	10791-10796	Protein	denotes	SOCS3
T22781	10637-10642	Protein	denotes	STAT4
T22780	10631-10636	Protein	denotes	IL-12
T22779	10617-10622	Protein	denotes	STAT6
T22778	10612-10616	Protein	denotes	IL-4
T22777	10493-10498	Protein	denotes	SOCS3
T22776	10483-10488	Protein	denotes	SOCS1
T22775	10459-10468	Positive_regulation	denotes	induction
T22774	10453-10458	Protein	denotes	SOCS1
T22773	10439-10449	Negative_regulation	denotes	diminished
T22772	10420-10425	Protein	denotes	STAT6
T22771	10412-10419	Positive_regulation	denotes	induced
T22770	10407-10411	Protein	denotes	IL-4
T22769	10375-10384	Positive_regulation	denotes	induction
T22768	10369-10374	Protein	denotes	SOCS3
T22767	10356-10365	Negative_regulation	denotes	inhibited
T22766	10342-10352	Positive_regulation	denotes	activation
T22697	8560-8565	Protein	denotes	SOCS1
T22696	8533-8542	Gene_expression	denotes	expressed
T22695	8491-8494	Protein	denotes	CD4
T22694	8350-8360	Positive_regulation	denotes	activation
T22693	8344-8349	Protein	denotes	STAT3
T22692	8335-8343	Positive_regulation	denotes	mediated
T22691	8329-8334	Protein	denotes	gp130
T22690	8228-8231	Protein	denotes	CD4
T22689	8181-8190	Protein	denotes	gp130F759
T22688	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T22687	8038-8043	Protein	denotes	gp130
T22686	8022-8029	Binding	denotes	binding
T22685	8019-8020	Entity	denotes	-
T22684	7961-7970	Protein	denotes	gp130F759
T22683	7865-7870	Protein	denotes	STAT3
T22682	7719-7724	Protein	denotes	STAT3
T22681	7686-7696	Gene_expression	denotes	production
T22680	7681-7685	Protein	denotes	IL-6
T22679	7599-7609	Positive_regulation	denotes	activation
T22678	7593-7598	Protein	denotes	STAT3
T22677	7553-7557	Protein	denotes	IL-6
T22676	7535-7542	Positive_regulation	denotes	induced
T22675	7514-7519	Protein	denotes	STAT3
T22674	7504-7513	Positive_regulation	denotes	activated
T22673	7445-7453	Protein	denotes	type III
T22672	7416-7440	Protein	denotes	Fc gamma receptor type I
T22671	7398-7408	Gene_expression	denotes	expression
T22670	7269-7274	Protein	denotes	STAT3
T22669	7251-7255	Protein	denotes	IL-6
T22668	7182-7191	Gene_expression	denotes	expressed
T22667	7158-7163	Protein	denotes	STAT3
T22666	7151-7157	Positive_regulation	denotes	Active
T22665	7093-7103	Positive_regulation	denotes	activation
T22664	7087-7092	Protein	denotes	STAT3
T22663	6928-6933	Protein	denotes	IL-10
T22662	6918-6924	Regulation	denotes	effect
T22661	6874-6879	Protein	denotes	IL-10
T22660	6861-6870	Negative_regulation	denotes	inhibitor
T22659	6832-6837	Protein	denotes	SOCS1
T22658	6825-6831	Positive_regulation	denotes	induce
T22657	6815-6820	Protein	denotes	IFN-γ
T22656	6800-6810	Positive_regulation	denotes	activation
T22655	6794-6799	Protein	denotes	STAT3
T22654	6784-6793	Positive_regulation	denotes	stimulate
T22653	6761-6766	Protein	denotes	IL-10
T22652	6650-6655	Protein	denotes	IL-10
T22651	6641-6649	Negative_regulation	denotes	impaired
T22650	6592-6595	Protein	denotes	CD4
T22649	6580-6588	Gene_expression	denotes	produced
T22648	6574-6579	Protein	denotes	IL-10
T22647	6564-6569	Protein	denotes	IFN-γ
T22646	6528-6532	Protein	denotes	IL-6
T22645	6487-6492	Protein	denotes	TNF-α
T22644	6477-6482	Protein	denotes	IL-1β
T22643	6448-6455	Negative_regulation	denotes	reduced
T22642	6431-6434	Protein	denotes	CD4
T22641	6417-6427	Negative_regulation	denotes	inhibition
T22640	6411-6416	Protein	denotes	IFN-γ
T22639	6402-6410	Positive_regulation	denotes	mediated
T22638	6396-6401	Protein	denotes	IL-10
T22637	6178-6182	Protein	denotes	IL-6
T22636	6122-6131	Positive_regulation	denotes	augmented
T22635	6104-6109	Protein	denotes	IL-10
T22634	6088-6091	Protein	denotes	CD4
T22633	6020-6025	Protein	denotes	STAT3
T22632	6012-6019	Positive_regulation	denotes	induced
T22631	6006-6011	Protein	denotes	IL-10
T22630	5938-5941	Protein	denotes	CD4
T22629	5926-5931	Protein	denotes	IL-10
T22628	5894-5903	Gene_expression	denotes	producing
T22627	5856-5859	Protein	denotes	CD4
T22626	5838-5843	Protein	denotes	IL-10
T22625	5805-5809	Negative_regulation	denotes	loss
T22624	5779-5788	Localization	denotes	secretion
T22623	5773-5778	Protein	denotes	IL-10
T22622	5747-5750	Protein	denotes	CD4
T22621	5736-5743	Positive_regulation	denotes	induced
T22620	5697-5702	Protein	denotes	STAT3
T22619	5657-5661	Protein	denotes	IL-6
T22618	5566-5569	Protein	denotes	CD4
T22617	5543-5553	Negative_regulation	denotes	inhibition
T22616	5537-5542	Protein	denotes	IL-10
T22615	5504-5514	Positive_regulation	denotes	activation
T22613	5446-5450	Protein	denotes	IL-6
T22612	5399-5402	Protein	denotes	CD4
T22611	5378-5388	Negative_regulation	denotes	suppressed
T22610	5368-5373	Protein	denotes	IL-10
T22609	5272-5277	Protein	denotes	STAT3
T22608	5253-5257	Protein	denotes	IL-6
T22607	5055-5059	Protein	denotes	IL-6
T22606	5024-5029	Protein	denotes	IL-10
T22605	4975-4987	Protein	denotes	oncostatin M
T22604	4943-4969	Protein	denotes	leukemia inhibitory factor
T22603	4936-4941	Protein	denotes	IL-11
T22602	4930-4934	Protein	denotes	IL-6
T22601	4850-4859	Positive_regulation	denotes	activated
T22600	4841-4846	Protein	denotes	STAT3
T22599	4810-4813	Protein	denotes	CD4
T22598	4736-4750	Phosphorylation	denotes	phosphorylated
T22597	4705-4710	Protein	denotes	STAT3
T22596	4693-4703	Positive_regulation	denotes	activation
T22595	4687-4692	Protein	denotes	STAT3
T22594	4678-4686	Positive_regulation	denotes	mediated
T22593	4672-4677	Protein	denotes	IL-10
T22592	4663-4671	Negative_regulation	denotes	impaired
T22591	4490-4495	Protein	denotes	IL-10
T22590	4479-4486	Regulation	denotes	effects
T22589	4468-4478	Negative_regulation	denotes	Inhibitory
T22588	4456-4466	Gene_expression	denotes	expression
T22587	4448-4455	Protein	denotes	IL-10R1
T22586	4423-4433	Positive_regulation	denotes	activation
T22585	4417-4422	Protein	denotes	STAT3
T22584	4407-4416	Regulation	denotes	dependent
T22583	4401-4406	Protein	denotes	IL-10
T22582	4391-4400	Negative_regulation	denotes	defective
T22581	4362-4367	Protein	denotes	IL-10
T22580	4346-4349	Protein	denotes	CD4
T22579	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T22578	4234-4238	Protein	denotes	IL-1
T22577	4227-4232	Protein	denotes	TNF-α
T22576	4159-4166	Protein	denotes	IL-10R1
T22575	4122-4131	Negative_regulation	denotes	decreased
T22574	4115-4118	Positive_regulation	denotes	due
T22573	4109-4114	Protein	denotes	IL-10
T22572	4099-4105	Regulation	denotes	effect
T22571	3889-3894	Protein	denotes	IFN-γ
T22570	3875-3885	Negative_regulation	denotes	suppressed
T22569	3860-3870	Positive_regulation	denotes	activation
T22568	3855-3859	Protein	denotes	Jak1
T22567	3847-3854	Positive_regulation	denotes	induced
T22566	3841-3846	Protein	denotes	IL-10
T22565	3826-3836	Gene_expression	denotes	expression
T22564	3818-3825	Protein	denotes	IL-10R1
T22563	3735-3742	Positive_regulation	denotes	induced
T22562	3707-3712	Protein	denotes	IL-10
T22561	3698-3706	Negative_regulation	denotes	impaired
T22560	3631-3641	Positive_regulation	denotes	activation
T22559	3625-3630	Protein	denotes	STAT3
T22558	3616-3624	Positive_regulation	denotes	mediated
T22557	3610-3615	Protein	denotes	IL-10
T22556	3558-3562	Protein	denotes	IL-6
T22555	3548-3553	Protein	denotes	IL-10
T22554	3514-3519	Protein	denotes	STAT3
T22553	3509-3513	Protein	denotes	Jak1
T22552	3496-3504	Negative_regulation	denotes	inhibits
T22551	3490-3494	Protein	denotes	IL-1
T22550	3480-3485	Protein	denotes	TNF-α
T22549	3469-3476	Positive_regulation	denotes	induced
T22548	3184-3192	Gene_expression	denotes	produced
T22547	3177-3182	Protein	denotes	IL-10
T22546	2968-2972	Protein	denotes	IL-2
T22545	2958-2963	Protein	denotes	IFN-γ
T22544	2939-2949	Gene_expression	denotes	production
T22543	2926-2938	Positive_regulation	denotes	costimulated
T22542	2921-2925	Protein	denotes	CD28
T22541	2907-2917	Negative_regulation	denotes	inhibition
T22540	2901-2906	Protein	denotes	IL-10
T22539	2891-2900	Negative_regulation	denotes	defective
T22538	2869-2872	Protein	denotes	CD4
T22537	2768-2783	Phosphorylation	denotes	phosphorylation
T22536	2754-2758	Protein	denotes	CD28
T22535	2743-2753	Negative_regulation	denotes	inhibiting
T22534	2664-2669	Protein	denotes	IL-10
T22533	2595-2599	Protein	denotes	CD86
T22532	2586-2590	Protein	denotes	CD80
T22531	2552-2559	Gene_expression	denotes	express
T22530	2286-2289	Protein	denotes	CD4
T22529	2257-2262	Protein	denotes	IL-10
T22528	2246-2255	Positive_regulation	denotes	induction
T22527	2240-2245	Protein	denotes	SOCS1
T22526	2220-2235	Phosphorylation	denotes	phosphorylation
T22525	2214-2219	Protein	denotes	STAT3
T22524	2204-2213	Positive_regulation	denotes	sustained
T22523	2187-2198	Binding	denotes	association
T22522	2172-2182	Positive_regulation	denotes	activation
T22521	2166-2171	Protein	denotes	STAT3
T22520	2156-2165	Regulation	denotes	dependent
T22519	2150-2155	Protein	denotes	IL-10
T22518	2141-2149	Negative_regulation	denotes	impaired
T22517	2040-2045	Protein	denotes	IL-10
T22516	2030-2036	Regulation	denotes	effect
T22515	1982-1985	Protein	denotes	CD4
T22514	1939-1942	Protein	denotes	CD4
T22513	1895-1900	Protein	denotes	SOCS3
T22512	1861-1866	Protein	denotes	SOCS1
T22511	1823-1826	Protein	denotes	CD4
T22510	1808-1818	Gene_expression	denotes	production
T22509	1802-1807	Protein	denotes	IFN-γ
T22508	1788-1798	Negative_regulation	denotes	inhibition
T22507	1782-1787	Protein	denotes	IL-10
T22506	1756-1763	Positive_regulation	denotes	induces
T22505	1751-1755	Protein	denotes	IL-6
T22504	1723-1726	Protein	denotes	CD4
T22503	1697-1712	Phosphorylation	denotes	phosphorylation
T22502	1691-1696	Protein	denotes	STAT1
T22501	1677-1682	Protein	denotes	STAT3
T22500	1669-1676	Positive_regulation	denotes	induces
T22499	1647-1651	Protein	denotes	IL-6
T22498	1634-1639	Protein	denotes	IL-10
T22497	1621-1630	Positive_regulation	denotes	inducible
T22496	1585-1600	Phosphorylation	denotes	phosphorylation
T22495	1579-1584	Protein	denotes	STAT3
T22494	1559-1562	Protein	denotes	CD4
T22493	1523-1526	Protein	denotes	CD4
T22492	1506-1516	Negative_regulation	denotes	suppressed
T22491	1497-1502	Protein	denotes	STAT3
T22490	1478-1493	Phosphorylation	denotes	phosphorylation
T22489	1461-1468	Positive_regulation	denotes	induced
T22488	1455-1460	Protein	denotes	IL-10
T22487	1443-1453	Positive_regulation	denotes	activation
T22486	1437-1442	Protein	denotes	STAT3
T22485	1409-1419	Gene_expression	denotes	expression
T22484	1401-1408	Protein	denotes	IL-10R1
T22483	1390-1394	Positive_regulation	denotes	high
T22482	1368-1371	Protein	denotes	CD4
T22446	10420-10425	Protein	denotes	STAT6
T22445	10407-10411	Protein	denotes	IL-4
T22444	10369-10374	Protein	denotes	SOCS3
T22443	10336-10341	Protein	denotes	STAT4
T22442	10322-10327	Protein	denotes	IL-12
T22441	10291-10296	Protein	denotes	SOCS3
T22440	10281-10286	Protein	denotes	SOCS1
T22439	10168-10173	Protein	denotes	SOCS1
T22438	10124-10129	Protein	denotes	IFN-γ
T22437	10105-10110	Protein	denotes	IL-10
T22436	10080-10085	Protein	denotes	IFN-γ
T22435	10023-10026	Protein	denotes	CD4
T22434	10008-10013	Protein	denotes	IFN-γ
T22433	9984-9987	Protein	denotes	CD4
T22432	9930-9935	Protein	denotes	SOCS1
T22431	9896-9900	Protein	denotes	IL-6
T22430	9858-9863	Protein	denotes	STAT3
T22429	9807-9812	Protein	denotes	SOCS3
T22428	9775-9780	Protein	denotes	STAT3
T22427	9760-9765	Protein	denotes	IL-10
T22426	9747-9752	Protein	denotes	IL-10
T22425	9665-9668	Protein	denotes	CD4
T22424	9642-9647	Protein	denotes	SOCS1
T22423	9601-9606	Protein	denotes	IL-10
T22422	9565-9570	Protein	denotes	SOCS1
T22421	9521-9526	Protein	denotes	IL-10
T22420	9423-9428	Protein	denotes	SOCS3
T22419	9370-9374	Protein	denotes	IL-6
T22418	9334-9339	Protein	denotes	SOCS3
T22417	9287-9292	Protein	denotes	SOCS3
T22416	9258-9262	Protein	denotes	IL-6
T22415	9237-9242	Protein	denotes	STAT3
T22414	9184-9189	Protein	denotes	SOCS1
T22413	9158-9163	Protein	denotes	SOCS3
T22412	9121-9126	Protein	denotes	SOCS3
T22411	9081-9086	Protein	denotes	IL-10
T22410	9055-9059	Protein	denotes	IL-6
T22409	9022-9027	Protein	denotes	SOCS3
T22408	9002-9007	Protein	denotes	SOCS1
T22407	8993-8998	Protein	denotes	SOCS3
T22406	8889-8894	Protein	denotes	IL-10
T22405	8880-8884	Protein	denotes	IL-6
T22404	8830-8835	Protein	denotes	SOCS3
T22403	8820-8825	Protein	denotes	SOCS1
T22402	8808-8813	Protein	denotes	gp130
T22401	8694-8699	Protein	denotes	SOCS3
T22400	8629-8634	Protein	denotes	SOCS1
T22399	8615-8618	Protein	denotes	CD4
T22398	8587-8592	Protein	denotes	SOCS3
T22397	8560-8565	Protein	denotes	SOCS1
T22396	8491-8494	Protein	denotes	CD4
T22395	8344-8349	Protein	denotes	STAT3
T22394	8329-8334	Protein	denotes	gp130
T22393	8228-8231	Protein	denotes	CD4
T22392	8181-8186	Protein	denotes	gp130
T22391	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T22390	8038-8043	Protein	denotes	gp130
T22389	7961-7966	Protein	denotes	gp130
T22388	7865-7870	Protein	denotes	STAT3
T22387	7719-7724	Protein	denotes	STAT3
T22386	7681-7685	Protein	denotes	IL-6
T22385	7593-7598	Protein	denotes	STAT3
T22384	7553-7557	Protein	denotes	IL-6
T22383	7514-7519	Protein	denotes	STAT3
T22382	7445-7453	Protein	denotes	type III
T22381	7416-7440	Protein	denotes	Fc gamma receptor type I
T22380	7269-7274	Protein	denotes	STAT3
T22379	7251-7255	Protein	denotes	IL-6
T22378	7158-7163	Protein	denotes	STAT3
T22377	7087-7092	Protein	denotes	STAT3
T22376	6928-6933	Protein	denotes	IL-10
T22375	6874-6879	Protein	denotes	IL-10
T22374	6832-6837	Protein	denotes	SOCS1
T22373	6815-6820	Protein	denotes	IFN-γ
T22372	6794-6799	Protein	denotes	STAT3
T22371	6761-6766	Protein	denotes	IL-10
T22370	6650-6655	Protein	denotes	IL-10
T22369	6592-6595	Protein	denotes	CD4
T22368	6574-6579	Protein	denotes	IL-10
T22367	6564-6569	Protein	denotes	IFN-γ
T22366	6528-6532	Protein	denotes	IL-6
T22365	6487-6492	Protein	denotes	TNF-α
T22364	6477-6482	Protein	denotes	IL-1β
T22363	6431-6434	Protein	denotes	CD4
T22362	6411-6416	Protein	denotes	IFN-γ
T22361	6396-6401	Protein	denotes	IL-10
T22360	6178-6182	Protein	denotes	IL-6
T22359	6104-6109	Protein	denotes	IL-10
T22358	6088-6091	Protein	denotes	CD4
T22357	6020-6025	Protein	denotes	STAT3
T22356	6006-6011	Protein	denotes	IL-10
T22355	5938-5941	Protein	denotes	CD4
T22354	5926-5931	Protein	denotes	IL-10
T22353	5856-5859	Protein	denotes	CD4
T22352	5838-5843	Protein	denotes	IL-10
T22351	5773-5778	Protein	denotes	IL-10
T22350	5747-5750	Protein	denotes	CD4
T22349	5697-5702	Protein	denotes	STAT3
T22348	5657-5661	Protein	denotes	IL-6
T22347	5566-5569	Protein	denotes	CD4
T22346	5537-5542	Protein	denotes	IL-10
T22345	5498-5503	Protein	denotes	STAT3
T22344	5446-5450	Protein	denotes	IL-6
T22343	5399-5402	Protein	denotes	CD4
T22342	5368-5373	Protein	denotes	IL-10
T22341	5272-5277	Protein	denotes	STAT3
T22340	5253-5257	Protein	denotes	IL-6
T22339	5055-5059	Protein	denotes	IL-6
T22338	5024-5029	Protein	denotes	IL-10
T22337	4975-4987	Protein	denotes	oncostatin M
T22336	4943-4969	Protein	denotes	leukemia inhibitory factor
T22335	4936-4941	Protein	denotes	IL-11
T22334	4930-4934	Protein	denotes	IL-6
T22333	4841-4846	Protein	denotes	STAT3
T22332	4810-4813	Protein	denotes	CD4
T22331	4705-4710	Protein	denotes	STAT3
T22330	4687-4692	Protein	denotes	STAT3
T22329	4672-4677	Protein	denotes	IL-10
T22328	4490-4495	Protein	denotes	IL-10
T22327	4448-4455	Protein	denotes	IL-10R1
T22326	4417-4422	Protein	denotes	STAT3
T22325	4401-4406	Protein	denotes	IL-10
T22324	4362-4367	Protein	denotes	IL-10
T22323	4346-4349	Protein	denotes	CD4
T22322	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T22321	4234-4238	Protein	denotes	IL-1
T22320	4227-4232	Protein	denotes	TNF-α
T22319	4159-4166	Protein	denotes	IL-10R1
T22318	4109-4114	Protein	denotes	IL-10
T22317	3889-3894	Protein	denotes	IFN-γ
T22316	3855-3859	Protein	denotes	Jak1
T22315	3841-3846	Protein	denotes	IL-10
T22314	3818-3825	Protein	denotes	IL-10R1
T22313	3707-3712	Protein	denotes	IL-10
T22312	3625-3630	Protein	denotes	STAT3
T22311	3610-3615	Protein	denotes	IL-10
T22310	3558-3562	Protein	denotes	IL-6
T22309	3548-3553	Protein	denotes	IL-10
T22308	3514-3519	Protein	denotes	STAT3
T22307	3509-3513	Protein	denotes	Jak1
T22306	3490-3494	Protein	denotes	IL-1
T22305	3480-3485	Protein	denotes	TNF-α
T22304	3177-3182	Protein	denotes	IL-10
T22303	2968-2972	Protein	denotes	IL-2
T22302	2958-2963	Protein	denotes	IFN-γ
T22301	2921-2925	Protein	denotes	CD28
T22300	2901-2906	Protein	denotes	IL-10
T22299	2869-2872	Protein	denotes	CD4
T22298	2754-2758	Protein	denotes	CD28
T22297	2664-2669	Protein	denotes	IL-10
T22296	2595-2599	Protein	denotes	CD86
T22295	2586-2590	Protein	denotes	CD80
T22294	2286-2289	Protein	denotes	CD4
T22293	2257-2262	Protein	denotes	IL-10
T22292	2240-2245	Protein	denotes	SOCS1
T22291	2214-2219	Protein	denotes	STAT3
T22290	2166-2171	Protein	denotes	STAT3
T22289	2150-2155	Protein	denotes	IL-10
T22288	2040-2045	Protein	denotes	IL-10
T22287	1982-1985	Protein	denotes	CD4
T22286	1939-1942	Protein	denotes	CD4
T22285	1895-1900	Protein	denotes	SOCS3
T22284	1861-1866	Protein	denotes	SOCS1
T22283	1823-1826	Protein	denotes	CD4
T22282	1802-1807	Protein	denotes	IFN-γ
T22281	1782-1787	Protein	denotes	IL-10
T22280	1751-1755	Protein	denotes	IL-6
T22279	1723-1726	Protein	denotes	CD4
T22278	1691-1696	Protein	denotes	STAT1
T22277	1677-1682	Protein	denotes	STAT3
T22276	1647-1651	Protein	denotes	IL-6
T22275	1634-1639	Protein	denotes	IL-10
T22274	1579-1584	Protein	denotes	STAT3
T22273	1559-1562	Protein	denotes	CD4
T22272	1523-1526	Protein	denotes	CD4
T22271	1497-1502	Protein	denotes	STAT3
T22270	1455-1460	Protein	denotes	IL-10
T22269	1437-1442	Protein	denotes	STAT3
T22268	1401-1408	Protein	denotes	IL-10R1
T22267	1368-1371	Protein	denotes	CD4
T22266	1337-1341	Protein	denotes	CD28
T22265	1317-1322	Protein	denotes	IFN-γ
T22264	1273-1278	Protein	denotes	IL-10
T22263	1211-1214	Protein	denotes	CD4
T22765	10336-10341	Protein	denotes	STAT4
T22764	10328-10335	Positive_regulation	denotes	induced
T22763	10322-10327	Protein	denotes	IL-12
T22762	10291-10296	Protein	denotes	SOCS3
T22761	10281-10286	Protein	denotes	SOCS1
T22760	10258-10265	Gene_expression	denotes	express
T22759	10168-10173	Protein	denotes	SOCS1
T22758	10124-10129	Protein	denotes	IFN-γ
T22757	10105-10110	Protein	denotes	IL-10
T22756	10080-10085	Protein	denotes	IFN-γ
T22755	10057-10064	Gene_expression	denotes	produce
T22754	10023-10026	Protein	denotes	CD4
T22753	10008-10013	Protein	denotes	IFN-γ
T22752	10000-10007	Gene_expression	denotes	produce
T22751	9984-9987	Protein	denotes	CD4
T22749	9896-9900	Protein	denotes	IL-6
T22748	9875-9886	Positive_regulation	denotes	in response
T22747	9864-9874	Positive_regulation	denotes	activation
T22746	9858-9863	Protein	denotes	STAT3
T22745	9831-9842	Positive_regulation	denotes	responsible
T22744	9813-9823	Gene_expression	denotes	expression
T22743	9807-9812	Protein	denotes	SOCS3
T22742	9781-9791	Positive_regulation	denotes	activation
T22741	9775-9780	Protein	denotes	STAT3
T22740	9766-9774	Positive_regulation	denotes	mediated
T22739	9760-9765	Protein	denotes	IL-10
T22738	9747-9752	Protein	denotes	IL-10
T22737	9720-9728	Negative_regulation	denotes	impaired
T22736	9665-9668	Protein	denotes	CD4
T22735	9648-9658	Gene_expression	denotes	expression
T22734	9642-9647	Protein	denotes	SOCS1
T22733	9632-9641	Positive_regulation	denotes	Increased
T22732	9601-9606	Protein	denotes	IL-10
T22731	9593-9600	Negative_regulation	denotes	inhibit
T22730	9565-9570	Protein	denotes	SOCS1
T22729	9521-9526	Protein	denotes	IL-10
T22728	9423-9428	Protein	denotes	SOCS3
T22727	9375-9382	Positive_regulation	denotes	induced
T22726	9370-9374	Protein	denotes	IL-6
T22725	9334-9339	Protein	denotes	SOCS3
T22724	9287-9292	Protein	denotes	SOCS3
T22723	9258-9262	Protein	denotes	IL-6
T22722	9243-9257	Positive_regulation	denotes	in response to
T22721	9237-9242	Protein	denotes	STAT3
T22720	9223-9233	Positive_regulation	denotes	activation
T22719	9190-9200	Negative_regulation	denotes	deficiency
T22718	9184-9189	Protein	denotes	SOCS1
T22717	9158-9163	Protein	denotes	SOCS3
T22716	9121-9126	Protein	denotes	SOCS3
T22715	9081-9086	Protein	denotes	IL-10
T22714	9055-9059	Protein	denotes	IL-6
T22713	9042-9051	Regulation	denotes	regulator
T22712	9022-9027	Protein	denotes	SOCS3
T22711	9002-9007	Protein	denotes	SOCS1
T22710	8993-8998	Protein	denotes	SOCS3
T22709	8889-8894	Protein	denotes	IL-10
T22708	8880-8884	Protein	denotes	IL-6
T22707	8840-8847	Positive_regulation	denotes	induced
T22706	8830-8835	Protein	denotes	SOCS3
T22705	8820-8825	Protein	denotes	SOCS1
T22704	8808-8813	Protein	denotes	gp130
T22703	8730-8737	Binding	denotes	binding
T22702	8694-8699	Protein	denotes	SOCS3
T22701	8674-8681	Binding	denotes	binding
T22700	8629-8634	Protein	denotes	SOCS1
T22699	8615-8618	Protein	denotes	CD4
T22698	8587-8592	Protein	denotes	SOCS3
T22262	1046-1050	Protein	denotes	CD28
T22261	995-1000	Protein	denotes	IL-10
T22260	852-857	Protein	denotes	IL-10
T22259	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T22258	661-665	Protein	denotes	CD28
T22257	493-497	Protein	denotes	CD86
T22256	484-488	Protein	denotes	CD80
T22255	465-469	Protein	denotes	CD28
T22254	414-418	Protein	denotes	CD28
T22253	333-336	Protein	denotes	CD4
T22252	101-104	Protein	denotes	CD4
T22251	11-14	Protein	denotes	CD4
T22481	1337-1341	Protein	denotes	CD28
T22480	1317-1322	Protein	denotes	IFN-γ
T22479	1292-1299	Gene_expression	denotes	produce
T22478	1273-1278	Protein	denotes	IL-10
T22477	1211-1214	Protein	denotes	CD4
T22476	1109-1116	Binding	denotes	binding
T22475	1046-1050	Protein	denotes	CD28
T22474	1023-1038	Phosphorylation	denotes	phosphorylation
T22473	1001-1009	Negative_regulation	denotes	inhibits
T22472	995-1000	Protein	denotes	IL-10
T22471	852-857	Protein	denotes	IL-10
T22470	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T22469	666-676	Binding	denotes	engagement
T22468	661-665	Protein	denotes	CD28
T22467	554-563	Gene_expression	denotes	expressed
T22466	493-497	Protein	denotes	CD86
T22465	484-488	Protein	denotes	CD80
T22464	465-469	Protein	denotes	CD28
T22463	414-418	Protein	denotes	CD28
T22462	400-409	Binding	denotes	occupancy
T22461	333-336	Protein	denotes	CD4
T22460	101-104	Protein	denotes	CD4
T22459	11-14	Protein	denotes	CD4
T22458	10959-10962	Protein	denotes	CD4
T22457	10936-10941	Protein	denotes	SOCS3
T22456	10908-10913	Protein	denotes	SOCS1
T22455	10818-10823	Protein	denotes	SOCS3
T22454	10791-10796	Protein	denotes	SOCS3
T22453	10637-10642	Protein	denotes	STAT4
T22452	10631-10636	Protein	denotes	IL-12
T22451	10617-10622	Protein	denotes	STAT6
T22450	10612-10616	Protein	denotes	IL-4
T22449	10493-10498	Protein	denotes	SOCS3
T22448	10483-10488	Protein	denotes	SOCS1
T22447	10453-10458	Protein	denotes	SOCS1
R10990	T22465	T22467	themeOf	CD80,expressed
R10991	T22466	T22467	themeOf	CD86,expressed
R10992	T22468	T22469	themeOf	CD28,engagement
R10993	T22472	T22473	causeOf	IL-10,inhibits
R10994	T22474	T22473	themeOf	phosphorylation,inhibits
R10995	T22475	T22474	themeOf	CD28,phosphorylation
R10996	T22480	T22479	themeOf	IFN-γ,produce
R10997	T22481	T22479	themeOf	CD28,produce
R10998	T22484	T22485	themeOf	IL-10R1,expression
R10999	T22486	T22487	themeOf	STAT3,activation
R11000	T22488	T22489	causeOf	IL-10,induced
R11001	T22489	T22492	themeOf	induced,suppressed
R11002	T22490	T22489	themeOf	phosphorylation,induced
R11003	T22490	T22492	themeOf	phosphorylation,suppressed
R11004	T22491	T22490	themeOf	STAT3,phosphorylation
R11005	T22495	T22496	themeOf	STAT3,phosphorylation
R11006	T22498	T22497	causeOf	IL-10,inducible
R11007	T22499	T22500	causeOf	IL-6,induces
R11008	T22501	T22503	themeOf	STAT3,phosphorylation
R11009	T22502	T22503	themeOf	STAT1,phosphorylation
R11010	T22503	T22500	themeOf	phosphorylation,induces
R11011	T22505	T22506	causeOf	IL-6,induces
R11012	T22507	T22508	causeOf	IL-10,inhibition
R11013	T22508	T22506	themeOf	inhibition,induces
R11014	T22509	T22510	themeOf	IFN-γ,production
R11015	T22510	T22508	themeOf	production,inhibition
R11016	T22519	T22520	causeOf	IL-10,dependent
R11017	T22520	T22518	themeOf	dependent,impaired
R11018	T22521	T22522	themeOf	STAT3,activation
R11019	T22522	T22520	themeOf	activation,dependent
R11020	T22525	T22526	themeOf	STAT3,phosphorylation
R11021	T22526	T22524	themeOf	phosphorylation,sustained
R11022	T22527	T22528	themeOf	SOCS1,induction
R11023	T22528	T22524	themeOf	induction,sustained
R11024	T22532	T22531	themeOf	CD80,express
R11025	T22533	T22531	themeOf	CD86,express
R11026	T22534	T22535	causeOf	IL-10,inhibiting
R11027	T22536	T22537	themeOf	CD28,phosphorylation
R11028	T22537	T22535	themeOf	phosphorylation,inhibiting
R11029	T22540	T22541	causeOf	IL-10,inhibition
R11030	T22541	T22539	themeOf	inhibition,defective
R11031	T22542	T22543	causeOf	CD28,costimulated
R11032	T22543	T22541	themeOf	costimulated,inhibition
R11033	T22544	T22543	themeOf	production,costimulated
R11034	T22545	T22544	themeOf	IFN-γ,production
R11035	T22546	T22544	themeOf	IL-2,production
R11036	T22547	T22548	themeOf	IL-10,produced
R11037	T22550	T22549	causeOf	TNF-α,induced
R11038	T22551	T22549	causeOf	IL-1,induced
R11039	T22555	T22552	causeOf	IL-10,inhibits
R11040	T22556	T22552	causeOf	IL-6,inhibits
R11041	T22557	T22558	causeOf	IL-10,mediated
R11042	T22559	T22560	themeOf	STAT3,activation
R11043	T22560	T22558	themeOf	activation,mediated
R11044	T22561	T22563	themeOf	impaired,induced
R11045	T22564	T22565	themeOf	IL-10R1,expression
R11046	T22567	T22570	themeOf	induced,suppressed
R11047	T22568	T22569	themeOf	Jak1,activation
R11048	T22569	T22567	themeOf	activation,induced
R11049	T22569	T22570	themeOf	activation,suppressed
R11050	T22571	T22570	causeOf	IFN-γ,suppressed
R11051	T22574	T22572	themeOf	due,effect
R11052	T22583	T22584	causeOf	IL-10,dependent
R11053	T22585	T22586	themeOf	STAT3,activation
R11054	T22586	T22584	themeOf	activation,dependent
R11055	T22587	T22588	themeOf	IL-10R1,expression
R11056	T22593	T22594	causeOf	IL-10,mediated
R11057	T22594	T22592	themeOf	mediated,impaired
R11058	T22595	T22596	themeOf	STAT3,activation
R11059	T22596	T22594	themeOf	activation,mediated
R11060	T22597	T22598	themeOf	STAT3,phosphorylated
R11061	T22600	T22601	themeOf	STAT3,activated
R11062	T22613	T22611	causeOf	IL-6,suppressed
R11063	T22614	T22615	themeOf	STAT3,activation
R11064	T22616	T22617	themeOf	IL-10,inhibition
R11065	T22620	T22621	themeOf	STAT3,induced
R11066	T22623	T22624	themeOf	IL-10,secretion
R11067	T22626	T22625	themeOf	IL-10,loss
R11068	T22629	T22628	themeOf	IL-10,producing
R11069	T22631	T22632	causeOf	IL-10,induced
R11070	T22637	T22636	causeOf	IL-6,augmented
R11071	T22638	T22639	causeOf	IL-10,mediated
R11072	T22639	T22643	themeOf	mediated,reduced
R11073	T22640	T22641	themeOf	IFN-γ,inhibition
R11074	T22641	T22639	themeOf	inhibition,mediated
R11075	T22644	T22643	causeOf	IL-1β,reduced
R11076	T22645	T22643	causeOf	TNF-α,reduced
R11077	T22647	T22649	themeOf	IFN-γ,produced
R11078	T22648	T22649	themeOf	IL-10,produced
R11079	T22653	T22658	causeOf	IL-10,induce
R11080	T22653	T22654	causeOf	IL-10,stimulate
R11081	T22655	T22656	themeOf	STAT3,activation
R11082	T22656	T22654	themeOf	activation,stimulate
R11083	T22659	T22658	themeOf	SOCS1,induce
R11084	T22664	T22665	themeOf	STAT3,activation
R11085	T22667	T22668	themeOf	STAT3,expressed
R11086	T22667	T22666	themeOf	STAT3,Active
R11087	T22672	T22671	themeOf	Fc gamma receptor type I,expression
R11088	T22673	T22671	themeOf	type III,expression
R11089	T22675	T22676	themeOf	STAT3,induced
R11090	T22675	T22674	themeOf	STAT3,activated
R11091	T22677	T22676	causeOf	IL-6,induced
R11092	T22678	T22679	themeOf	STAT3,activation
R11093	T22680	T22681	themeOf	IL-6,production
R11094	T22691	T22692	causeOf	gp130,mediated
R11095	T22693	T22694	themeOf	STAT3,activation
R11096	T22694	T22692	themeOf	activation,mediated
R11097	T22697	T22696	themeOf	SOCS1,expressed
R11098	T22698	T22696	themeOf	SOCS3,expressed
R11099	T22700	T22701	themeOf	SOCS1,binding
R11100	T22702	T22703	themeOf	SOCS3,binding
R11101	T22702	T22701	themeOf	SOCS3,binding
R11102	T22704	T22703	themeOf	gp130,binding
R11103	T22705	T22707	themeOf	SOCS1,induced
R11104	T22706	T22707	themeOf	SOCS3,induced
R11105	T22708	T22707	causeOf	IL-6,induced
R11106	T22709	T22707	causeOf	IL-10,induced
R11107	T22718	T22719	themeOf	SOCS1,deficiency
R11108	T22720	T22722	themeOf	activation,in response to
R11109	T22721	T22720	themeOf	STAT3,activation
R11110	T22721	T22722	themeOf	STAT3,in response to
R11111	T22723	T22722	causeOf	IL-6,in response to
R11112	T22725	T22727	causeOf	SOCS3,induced
R11113	T22726	T22727	causeOf	IL-6,induced
R11114	T22730	T22731	causeOf	SOCS1,inhibit
R11115	T22734	T22735	themeOf	SOCS1,expression
R11116	T22735	T22733	themeOf	expression,Increased
R11117	T22739	T22740	causeOf	IL-10,mediated
R11118	T22741	T22742	themeOf	STAT3,activation
R11119	T22742	T22740	themeOf	activation,mediated
R11120	T22743	T22744	themeOf	SOCS3,expression
R11121	T22744	T22745	causeOf	expression,responsible
R11122	T22746	T22747	themeOf	STAT3,activation
R11123	T22749	T22748	causeOf	IL-6,in response
R11124	T22753	T22752	themeOf	IFN-γ,produce
R11125	T22756	T22755	themeOf	IFN-γ,produce
R11126	T22761	T22760	themeOf	SOCS1,express
R11127	T22762	T22760	themeOf	SOCS3,express
R11128	T22763	T22764	causeOf	IL-12,induced
R11129	T22764	T22767	themeOf	induced,inhibited
R11130	T22765	T22766	themeOf	STAT4,activation
R11131	T22766	T22764	themeOf	activation,induced
R11132	T22766	T22767	themeOf	activation,inhibited
R11133	T22768	T22769	themeOf	SOCS3,induction
R11134	T22770	T22771	causeOf	IL-4,induced
R11135	T22771	T22773	themeOf	induced,diminished
R11136	T22774	T22775	themeOf	SOCS1,induction
R11137	T22785	T22786	themeOf	SOCS3,expression

testone

Id	Subject	Object	Predicate	Lexical cue
T22047	10942-10952	Gene_expression	denotes	expression
T22046	10914-10924	Gene_expression	denotes	expression
T22045	10824-10834	Gene_expression	denotes	expression
T22044	10459-10468	Positive_regulation	denotes	induction
T22043	10439-10449	Negative_regulation	denotes	diminished
T22042	10412-10419	Positive_regulation	denotes	induced
T22041	10375-10384	Positive_regulation	denotes	induction
T22040	10356-10365	Negative_regulation	denotes	inhibited
T22039	10342-10352	Positive_regulation	denotes	activation
T22038	10328-10335	Positive_regulation	denotes	induced
T22037	10258-10265	Gene_expression	denotes	express
T22036	10093-10101	Positive_regulation	denotes	presence
T22035	10065-10069	Positive_regulation	denotes	high
T22034	10057-10064	Gene_expression	denotes	produce
T22033	10000-10007	Gene_expression	denotes	produce
T22032	9878-9889	Positive_regulation	denotes	response to
T22031	9864-9874	Positive_regulation	denotes	activation
T22030	9831-9842	Positive_regulation	denotes	responsible
T22029	9813-9823	Gene_expression	denotes	expression
T22028	9797-9806	Negative_regulation	denotes	defective
T22027	9781-9791	Positive_regulation	denotes	activation
T22026	9766-9774	Positive_regulation	denotes	mediated
T22025	9648-9658	Gene_expression	denotes	expression
T22024	9632-9641	Positive_regulation	denotes	Increased
T22023	9293-9302	Negative_regulation	denotes	deficient
T22022	9243-9257	Positive_regulation	denotes	in response to
T22021	9223-9233	Positive_regulation	denotes	activation
T22020	9190-9200	Negative_regulation	denotes	deficiency
T22019	9127-9136	Negative_regulation	denotes	deficient
T22018	8985-8992	Negative_regulation	denotes	lacking
T22017	8730-8737	Binding	denotes	binding
T22016	8700-8708	Negative_regulation	denotes	inhibits
T22015	8674-8681	Binding	denotes	binding
T22014	8644-8654	Positive_regulation	denotes	activation
T22013	8533-8542	Gene_expression	denotes	expressed
T22012	8434-8443	Regulation	denotes	regulated
T22011	8350-8360	Positive_regulation	denotes	activation
T22010	8335-8343	Positive_regulation	denotes	mediated
T22009	8030-8034	Entity	denotes	site
T22008	8022-8029	Binding	denotes	binding
T22007	7999-8021	Entity	denotes	homology phosphatase-2
T22006	7686-7696	Gene_expression	denotes	production
T22005	7599-7609	Positive_regulation	denotes	activation
T22004	7535-7542	Positive_regulation	denotes	induced
T22003	7504-7513	Positive_regulation	denotes	activated
T22002	7182-7191	Gene_expression	denotes	expressed
T22001	7151-7157	Positive_regulation	denotes	Active
T22000	7093-7103	Positive_regulation	denotes	activation
T21999	6825-6831	Positive_regulation	denotes	induce
T21998	6800-6810	Positive_regulation	denotes	activation
T21874	8993-8998	Protein	denotes	SOCS3
T21873	8889-8894	Protein	denotes	IL-10
T21872	8880-8884	Protein	denotes	IL-6
T21871	8830-8835	Protein	denotes	SOCS3
T21870	8820-8825	Protein	denotes	SOCS1
T21869	8808-8813	Protein	denotes	gp130
T21868	8694-8699	Protein	denotes	SOCS3
T21867	8629-8634	Protein	denotes	SOCS1
T21866	8615-8618	Protein	denotes	CD4
T21865	8587-8592	Protein	denotes	SOCS3
T21864	8560-8565	Protein	denotes	SOCS1
T21863	8491-8494	Protein	denotes	CD4
T21862	8344-8349	Protein	denotes	STAT3
T21861	8329-8334	Protein	denotes	gp130
T21860	8228-8231	Protein	denotes	CD4
T21859	8181-8186	Protein	denotes	gp130
T21858	8049-8122	Protein	denotes	transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T21857	8038-8043	Protein	denotes	gp130
T21856	7961-7966	Protein	denotes	gp130
T21855	7865-7870	Protein	denotes	STAT3
T21854	7719-7724	Protein	denotes	STAT3
T21853	7681-7685	Protein	denotes	IL-6
T21852	7593-7598	Protein	denotes	STAT3
T21851	7553-7557	Protein	denotes	IL-6
T21850	7514-7519	Protein	denotes	STAT3
T21849	7445-7453	Protein	denotes	type III
T21848	7416-7440	Protein	denotes	Fc gamma receptor type I
T21847	7269-7274	Protein	denotes	STAT3
T21846	7251-7255	Protein	denotes	IL-6
T21845	7158-7163	Protein	denotes	STAT3
T21844	7087-7092	Protein	denotes	STAT3
T21843	6928-6933	Protein	denotes	IL-10
T21842	6874-6879	Protein	denotes	IL-10
T21841	6832-6837	Protein	denotes	SOCS1
T21840	6815-6820	Protein	denotes	IFN-γ
T21839	6794-6799	Protein	denotes	STAT3
T21838	6761-6766	Protein	denotes	IL-10
T21837	6650-6655	Protein	denotes	IL-10
T21836	6592-6595	Protein	denotes	CD4
T21835	6574-6579	Protein	denotes	IL-10
T21834	6564-6569	Protein	denotes	IFN-γ
T21833	6528-6532	Protein	denotes	IL-6
T21832	6487-6492	Protein	denotes	TNF-α
T21831	6477-6482	Protein	denotes	IL-1β
T21830	6431-6434	Protein	denotes	CD4
T21829	6411-6416	Protein	denotes	IFN-γ
T21828	6396-6401	Protein	denotes	IL-10
T21827	6178-6182	Protein	denotes	IL-6
T21826	6104-6109	Protein	denotes	IL-10
T21825	6088-6091	Protein	denotes	CD4
T21824	6020-6025	Protein	denotes	STAT3
T21823	6006-6011	Protein	denotes	IL-10
T21822	5938-5941	Protein	denotes	CD4
T21821	5926-5931	Protein	denotes	IL-10
T21820	5856-5859	Protein	denotes	CD4
T21819	5838-5843	Protein	denotes	IL-10
T21818	5773-5778	Protein	denotes	IL-10
T21817	5747-5750	Protein	denotes	CD4
T21816	5697-5702	Protein	denotes	STAT3
T21815	5657-5661	Protein	denotes	IL-6
T21814	5566-5569	Protein	denotes	CD4
T21813	5537-5542	Protein	denotes	IL-10
T21812	5498-5503	Protein	denotes	STAT3
T21811	5446-5450	Protein	denotes	IL-6
T21810	5399-5402	Protein	denotes	CD4
T21809	5368-5373	Protein	denotes	IL-10
T21808	5272-5277	Protein	denotes	STAT3
T21807	5253-5257	Protein	denotes	IL-6
T21806	5055-5059	Protein	denotes	IL-6
T21805	5024-5029	Protein	denotes	IL-10
T21804	4975-4987	Protein	denotes	oncostatin M
T21803	4943-4969	Protein	denotes	leukemia inhibitory factor
T21802	4936-4941	Protein	denotes	IL-11
T21801	4930-4934	Protein	denotes	IL-6
T21800	4841-4846	Protein	denotes	STAT3
T21799	4810-4813	Protein	denotes	CD4
T21798	4705-4710	Protein	denotes	STAT3
T21797	4687-4692	Protein	denotes	STAT3
T21796	4672-4677	Protein	denotes	IL-10
T21795	4490-4495	Protein	denotes	IL-10
T21794	4448-4455	Protein	denotes	IL-10R1
T21793	4417-4422	Protein	denotes	STAT3
T21792	4401-4406	Protein	denotes	IL-10
T21791	4362-4367	Protein	denotes	IL-10
T21790	4346-4349	Protein	denotes	CD4
T21789	4244-4292	Protein	denotes	granulocyte–macrophage colony-stimulating factor
T21788	4234-4238	Protein	denotes	IL-1
T21787	4227-4232	Protein	denotes	TNF-α
T21786	4159-4166	Protein	denotes	IL-10R1
T21785	4109-4114	Protein	denotes	IL-10
T21784	3889-3894	Protein	denotes	IFN-γ
T21783	3855-3859	Protein	denotes	Jak1
T21782	3841-3846	Protein	denotes	IL-10
T21781	3818-3825	Protein	denotes	IL-10R1
T21780	3707-3712	Protein	denotes	IL-10
T21779	3625-3630	Protein	denotes	STAT3
T21778	3610-3615	Protein	denotes	IL-10
T21777	3548-3553	Protein	denotes	IL-10
T21776	3514-3519	Protein	denotes	STAT3
T21775	3509-3513	Protein	denotes	Jak1
T21774	3490-3494	Protein	denotes	IL-1
T21773	3480-3485	Protein	denotes	TNF-α
T21772	3177-3182	Protein	denotes	IL-10
T21771	2968-2972	Protein	denotes	IL-2
T21770	2958-2963	Protein	denotes	IFN-γ
T21769	2921-2925	Protein	denotes	CD28
T21768	2901-2906	Protein	denotes	IL-10
T21767	2869-2872	Protein	denotes	CD4
T21766	2754-2758	Protein	denotes	CD28
T21765	2664-2669	Protein	denotes	IL-10
T21764	2595-2599	Protein	denotes	CD86
T21763	2586-2590	Protein	denotes	CD80
T21762	2286-2289	Protein	denotes	CD4
T21761	2257-2262	Protein	denotes	IL-10
T21760	2240-2245	Protein	denotes	SOCS1
T21759	2214-2219	Protein	denotes	STAT3
T21758	2166-2171	Protein	denotes	STAT3
T21757	2150-2155	Protein	denotes	IL-10
T21756	2040-2045	Protein	denotes	IL-10
T21755	1982-1985	Protein	denotes	CD4
T21754	1939-1942	Protein	denotes	CD4
T21753	1895-1900	Protein	denotes	SOCS3
T21752	1861-1866	Protein	denotes	SOCS1
T21751	1823-1826	Protein	denotes	CD4
T21750	1802-1807	Protein	denotes	IFN-γ
T21749	1782-1787	Protein	denotes	IL-10
T21748	1751-1755	Protein	denotes	IL-6
T21747	1723-1726	Protein	denotes	CD4
T21746	1691-1696	Protein	denotes	STAT1
T21745	1677-1682	Protein	denotes	STAT3
T21744	1647-1651	Protein	denotes	IL-6
T21743	1634-1639	Protein	denotes	IL-10
T21742	1579-1584	Protein	denotes	STAT3
T21741	1559-1562	Protein	denotes	CD4
T21740	1523-1526	Protein	denotes	CD4
T21739	1497-1502	Protein	denotes	STAT3
T21738	1455-1460	Protein	denotes	IL-10
T21737	1437-1442	Protein	denotes	STAT3
T21736	1401-1408	Protein	denotes	IL-10R1
T21735	1368-1371	Protein	denotes	CD4
T21734	1337-1341	Protein	denotes	CD28
T21733	1317-1322	Protein	denotes	IFN-γ
T21732	1273-1278	Protein	denotes	IL-10
T21731	1211-1214	Protein	denotes	CD4
T21730	1046-1050	Protein	denotes	CD28
T21729	995-1000	Protein	denotes	IL-10
T21728	852-857	Protein	denotes	IL-10
T21727	781-830	Protein	denotes	cytotoxic T-cell-associated antigen 4 (CD152)-IgG
T21726	661-665	Protein	denotes	CD28
T21725	493-497	Protein	denotes	CD86
T21724	484-488	Protein	denotes	CD80
T21723	465-469	Protein	denotes	CD28
T21722	414-418	Protein	denotes	CD28
T21721	333-336	Protein	denotes	CD4
T21720	101-104	Protein	denotes	CD4
T21719	11-14	Protein	denotes	CD4
T21718	3558-3562	Protein	denotes	IL-6
T21997	6784-6793	Positive_regulation	denotes	stimulate
T21996	6704-6711	Gene_expression	denotes	produce
T21995	6580-6588	Gene_expression	denotes	produced
T21994	6448-6455	Negative_regulation	denotes	reduced
T21993	6417-6427	Negative_regulation	denotes	inhibition
T21992	6402-6410	Positive_regulation	denotes	mediated
T21991	6122-6131	Positive_regulation	denotes	augmented
T21990	6012-6019	Positive_regulation	denotes	induced
T21989	5894-5903	Gene_expression	denotes	producing
T21988	5805-5809	Negative_regulation	denotes	loss
T21987	5779-5788	Localization	denotes	secretion
T21986	5736-5743	Positive_regulation	denotes	induced
T21985	5586-5593	Positive_regulation	denotes	induced
T21984	5543-5553	Negative_regulation	denotes	inhibition
T21983	5504-5514	Positive_regulation	denotes	activation
T21982	5378-5388	Negative_regulation	denotes	suppressed
T21981	4850-4859	Positive_regulation	denotes	activated
T21980	4736-4750	Phosphorylation	denotes	phosphorylated
T21979	4727-4735	Entity	denotes	tyrosine
T21978	4693-4703	Positive_regulation	denotes	activation
T21977	4678-4686	Positive_regulation	denotes	mediated
T21976	4663-4671	Negative_regulation	denotes	impaired
T21975	4646-4657	Binding	denotes	association
T21974	4479-4486	Regulation	denotes	effects
T21973	4468-4478	Negative_regulation	denotes	Inhibitory
T21972	4456-4466	Gene_expression	denotes	expression
T21971	4423-4433	Positive_regulation	denotes	activation
T21970	4407-4416	Positive_regulation	denotes	dependent
T21969	4391-4400	Negative_regulation	denotes	defective
T21968	4122-4131	Negative_regulation	denotes	decreased
T21967	4115-4118	Positive_regulation	denotes	due
T21966	3875-3885	Negative_regulation	denotes	suppressed
T21965	3860-3870	Positive_regulation	denotes	activation
T21964	3847-3854	Positive_regulation	denotes	induced
T21963	3826-3836	Gene_expression	denotes	expression
T21962	3735-3742	Positive_regulation	denotes	induced
T21961	3631-3641	Positive_regulation	denotes	activation
T21960	3616-3624	Positive_regulation	denotes	mediated
T21959	3496-3504	Negative_regulation	denotes	inhibits
T21958	3469-3476	Positive_regulation	denotes	induced
T21957	3184-3192	Gene_expression	denotes	produced
T21956	2939-2949	Gene_expression	denotes	production
T21955	2926-2938	Positive_regulation	denotes	costimulated
T21954	2907-2917	Negative_regulation	denotes	inhibition
T21953	2891-2900	Negative_regulation	denotes	defective
T21952	2552-2559	Gene_expression	denotes	express
T21951	2246-2255	Positive_regulation	denotes	induction
T21950	2220-2235	Phosphorylation	denotes	phosphorylation
T21949	2204-2213	Positive_regulation	denotes	sustained
T21948	2187-2198	Binding	denotes	association
T21947	2172-2182	Positive_regulation	denotes	activation
T21946	2156-2165	Positive_regulation	denotes	dependent
T21945	2141-2149	Negative_regulation	denotes	impaired
T21944	2125-2137	Positive_regulation	denotes	attributable
T21943	1808-1818	Gene_expression	denotes	production
T21942	1788-1798	Negative_regulation	denotes	inhibition
T21941	1756-1763	Positive_regulation	denotes	induces
T21940	1697-1712	Phosphorylation	denotes	phosphorylation
T21939	1669-1676	Positive_regulation	denotes	induces
T21938	1621-1630	Positive_regulation	denotes	inducible
T21937	1585-1600	Phosphorylation	denotes	phosphorylation
T21936	1506-1516	Negative_regulation	denotes	suppressed
T21935	1478-1493	Phosphorylation	denotes	phosphorylation
T21934	1461-1468	Positive_regulation	denotes	induced
T21933	1443-1453	Positive_regulation	denotes	activation
T21932	1409-1419	Gene_expression	denotes	expression
T21931	1300-1306	Positive_regulation	denotes	higher
T21930	1292-1299	Gene_expression	denotes	produce
T21929	1023-1038	Phosphorylation	denotes	phosphorylation
T21928	1001-1009	Negative_regulation	denotes	inhibits
T21927	666-676	Binding	denotes	engagement
T21926	554-563	Gene_expression	denotes	expressed
T21925	10959-10962	Protein	denotes	CD4
T21924	10936-10941	Protein	denotes	SOCS3
T21923	10908-10913	Protein	denotes	SOCS1
T21922	10818-10823	Protein	denotes	SOCS3
T21921	10791-10796	Protein	denotes	SOCS3
T21920	10637-10642	Protein	denotes	STAT4
T21919	10631-10636	Protein	denotes	IL-12
T21918	10617-10622	Protein	denotes	STAT6
T21917	10612-10616	Protein	denotes	IL-4
T21916	10493-10498	Protein	denotes	SOCS3
T21915	10483-10488	Protein	denotes	SOCS1
T21914	10453-10458	Protein	denotes	SOCS1
T21913	10420-10425	Protein	denotes	STAT6
T21912	10407-10411	Protein	denotes	IL-4
T21911	10369-10374	Protein	denotes	SOCS3
T21910	10336-10341	Protein	denotes	STAT4
T21909	10322-10327	Protein	denotes	IL-12
T21908	10291-10296	Protein	denotes	SOCS3
T21907	10281-10286	Protein	denotes	SOCS1
T21906	10168-10173	Protein	denotes	SOCS1
T21905	10124-10129	Protein	denotes	IFN-γ
T21904	10105-10110	Protein	denotes	IL-10
T21903	10080-10085	Protein	denotes	IFN-γ
T21902	10023-10026	Protein	denotes	CD4
T21901	10008-10013	Protein	denotes	IFN-γ
T21900	9984-9987	Protein	denotes	CD4
T21899	9930-9935	Protein	denotes	SOCS1
T21898	9896-9900	Protein	denotes	IL-6
T21897	9858-9863	Protein	denotes	STAT3
T21896	9807-9812	Protein	denotes	SOCS3
T21895	9775-9780	Protein	denotes	STAT3
T21894	9760-9765	Protein	denotes	IL-10
T21893	9747-9752	Protein	denotes	IL-10
T21892	9665-9668	Protein	denotes	CD4
T21891	9642-9647	Protein	denotes	SOCS1
T21890	9601-9606	Protein	denotes	IL-10
T21889	9565-9570	Protein	denotes	SOCS1
T21888	9521-9526	Protein	denotes	IL-10
T21887	9423-9428	Protein	denotes	SOCS3
T21886	9370-9374	Protein	denotes	IL-6
T21885	9334-9339	Protein	denotes	SOCS3
T21884	9287-9292	Protein	denotes	SOCS3
T21883	9258-9262	Protein	denotes	IL-6
T21882	9237-9242	Protein	denotes	STAT3
T21881	9184-9189	Protein	denotes	SOCS1
T21880	9158-9163	Protein	denotes	SOCS3
T21879	9121-9126	Protein	denotes	SOCS3
T21878	9081-9086	Protein	denotes	IL-10
T21877	9055-9059	Protein	denotes	IL-6
T21876	9022-9027	Protein	denotes	SOCS3
T21875	9002-9007	Protein	denotes	SOCS1
R10839	T21718	T21959	causeOf	IL-6,inhibits
R10840	T21724	T21926	themeOf	CD80,expressed
R10841	T21725	T21926	themeOf	CD86,expressed
R10842	T21726	T21927	themeOf	CD28,engagement
R10843	T21729	T21928	causeOf	IL-10,inhibits
R10844	T21733	T21930	themeOf	IFN-γ,produce
R10845	T21734	T21930	themeOf	CD28,produce
R10846	T21736	T21932	themeOf	IL-10R1,expression
R10847	T21737	T21933	themeOf	STAT3,activation
R10848	T21738	T21934	causeOf	IL-10,induced
R10849	T21739	T21935	themeOf	STAT3,phosphorylation
R10850	T21742	T21937	themeOf	STAT3,phosphorylation
R10851	T21743	T21938	causeOf	IL-10,inducible
R10852	T21744	T21939	causeOf	IL-6,induces
R10853	T21745	T21940	themeOf	STAT3,phosphorylation
R10854	T21746	T21940	themeOf	STAT1,phosphorylation
R10855	T21748	T21941	causeOf	IL-6,induces
R10856	T21749	T21942	causeOf	IL-10,inhibition
R10857	T21750	T21943	themeOf	IFN-γ,production
R10858	T21757	T21946	causeOf	IL-10,dependent
R10859	T21758	T21947	themeOf	STAT3,activation
R10860	T21759	T21950	themeOf	STAT3,phosphorylation
R10861	T21760	T21951	themeOf	SOCS1,induction
R10862	T21763	T21952	themeOf	CD80,express
R10863	T21764	T21952	themeOf	CD86,express
R10864	T21768	T21954	causeOf	IL-10,inhibition
R10865	T21768	T21953	themeOf	IL-10,defective
R10866	T21769	T21955	causeOf	CD28,costimulated
R10867	T21770	T21956	themeOf	IFN-γ,production
R10868	T21771	T21956	themeOf	IL-2,production
R10869	T21772	T21957	themeOf	IL-10,produced
R10870	T21773	T21958	causeOf	TNF-α,induced
R10871	T21774	T21958	causeOf	IL-1,induced
R10872	T21777	T21959	causeOf	IL-10,inhibits
R10873	T21778	T21960	causeOf	IL-10,mediated
R10874	T21779	T21961	themeOf	STAT3,activation
R10875	T21781	T21963	themeOf	IL-10R1,expression
R10876	T21783	T21965	themeOf	Jak1,activation
R10877	T21784	T21966	causeOf	IFN-γ,suppressed
R10878	T21787	T21968	causeOf	TNF-α,decreased
R10879	T21788	T21968	causeOf	IL-1,decreased
R10880	T21792	T21970	causeOf	IL-10,dependent
R10881	T21793	T21971	themeOf	STAT3,activation
R10882	T21794	T21972	themeOf	IL-10R1,expression
R10883	T21796	T21977	causeOf	IL-10,mediated
R10884	T21797	T21978	themeOf	STAT3,activation
R10885	T21798	T21980	themeOf	STAT3,phosphorylated
R10886	T21800	T21981	themeOf	STAT3,activated
R10887	T21811	T21982	causeOf	IL-6,suppressed
R10888	T21812	T21983	themeOf	STAT3,activation
R10889	T21813	T21984	themeOf	IL-10,inhibition
R10890	T21815	T21985	causeOf	IL-6,induced
R10891	T21818	T21987	themeOf	IL-10,secretion
R10892	T21819	T21988	themeOf	IL-10,loss
R10893	T21821	T21989	themeOf	IL-10,producing
R10894	T21823	T21990	causeOf	IL-10,induced
R10895	T21827	T21991	causeOf	IL-6,augmented
R10896	T21828	T21992	causeOf	IL-10,mediated
R10897	T21829	T21993	themeOf	IFN-γ,inhibition
R10898	T21831	T21994	causeOf	IL-1β,reduced
R10899	T21832	T21994	causeOf	TNF-α,reduced
R10900	T21833	T21994	causeOf	IL-6,reduced
R10901	T21834	T21995	themeOf	IFN-γ,produced
R10902	T21835	T21995	themeOf	IL-10,produced
R10903	T21838	T21997	causeOf	IL-10,stimulate
R10904	T21839	T21998	themeOf	STAT3,activation
R10905	T21841	T21999	themeOf	SOCS1,induce
R10906	T21844	T22000	themeOf	STAT3,activation
R10907	T21845	T22002	themeOf	STAT3,expressed
R10908	T21850	T22003	themeOf	STAT3,activated
R10909	T21851	T22004	causeOf	IL-6,induced
R10910	T21852	T22005	themeOf	STAT3,activation
R10911	T21853	T22006	themeOf	IL-6,production
R10912	T21861	T22010	causeOf	gp130,mediated
R10913	T21862	T22011	themeOf	STAT3,activation
R10914	T21867	T22015	themeOf	SOCS1,binding
R10915	T21867	T22017	themeOf	SOCS1,binding
R10916	T21868	T22015	themeOf	SOCS3,binding
R10917	T21869	T22017	themeOf	gp130,binding
R10918	T21874	T22018	themeOf	SOCS3,lacking
R10919	T21875	T22018	themeOf	SOCS1,lacking
R10920	T21879	T22019	themeOf	SOCS3,deficient
R10921	T21881	T22020	themeOf	SOCS1,deficiency
R10922	T21882	T22021	themeOf	STAT3,activation
R10923	T21882	T22022	themeOf	STAT3,in response to
R10924	T21883	T22022	causeOf	IL-6,in response to
R10925	T21884	T22023	themeOf	SOCS3,deficient
R10926	T21891	T22025	themeOf	SOCS1,expression
R10927	T21894	T22026	causeOf	IL-10,mediated
R10928	T21895	T22027	themeOf	STAT3,activation
R10929	T21896	T22029	themeOf	SOCS3,expression
R10930	T21897	T22031	themeOf	STAT3,activation
R10931	T21898	T22032	themeOf	IL-6,response to
R10932	T21901	T22033	themeOf	IFN-γ,produce
R10933	T21903	T22034	themeOf	IFN-γ,produce
R10934	T21904	T22035	causeOf	IL-10,high
R10935	T21905	T22035	causeOf	IFN-γ,high
R10936	T21907	T22037	themeOf	SOCS1,express
R10937	T21908	T22037	themeOf	SOCS3,express
R10938	T21909	T22038	causeOf	IL-12,induced
R10939	T21910	T22039	themeOf	STAT4,activation
R10940	T21911	T22041	themeOf	SOCS3,induction
R10941	T21912	T22042	causeOf	IL-4,induced
R10942	T21914	T22044	themeOf	SOCS1,induction
R10943	T21922	T22045	themeOf	SOCS3,expression
R10944	T21923	T22046	themeOf	SOCS1,expression
R10945	T21924	T22047	themeOf	SOCS3,expression
R10946	T21929	T21928	themeOf	phosphorylation,inhibits
R10947	T21930	T21931	themeOf	produce,higher
R10948	T21934	T21936	themeOf	induced,suppressed
R10949	T21935	T21934	themeOf	phosphorylation,induced
R10950	T21935	T21936	themeOf	phosphorylation,suppressed
R10951	T21937	T21938	themeOf	phosphorylation,inducible
R10952	T21940	T21939	themeOf	phosphorylation,induces
R10953	T21942	T21941	themeOf	inhibition,induces
R10954	T21943	T21942	themeOf	production,inhibition
R10955	T21946	T21945	themeOf	dependent,impaired
R10956	T21947	T21946	themeOf	activation,dependent
R10957	T21950	T21949	themeOf	phosphorylation,sustained
R10958	T21951	T21949	themeOf	induction,sustained
R10959	T21955	T21954	themeOf	costimulated,inhibition
R10960	T21956	T21955	themeOf	production,costimulated
R10961	T21961	T21960	themeOf	activation,mediated
R10962	T21965	T21964	themeOf	activation,induced
R10963	T21965	T21966	themeOf	activation,suppressed
R10964	T21970	T21969	themeOf	dependent,defective
R10965	T21971	T21970	themeOf	activation,dependent
R10966	T21972	T21970	themeOf	expression,dependent
R10967	T21977	T21976	themeOf	mediated,impaired
R10968	T21978	T21977	themeOf	activation,mediated
R10969	T21979	T21980	themeOf	tyrosine,phosphorylated
R10970	T21983	T21985	themeOf	activation,induced
R10971	T21992	T21994	themeOf	mediated,reduced
R10972	T21993	T21992	themeOf	inhibition,mediated
R10973	T21998	T21997	themeOf	activation,stimulate
R10974	T22003	T22004	themeOf	activated,induced
R10975	T22005	T22004	causeOf	activation,induced
R10976	T22007	T22008	themeOf	homology phosphatase-2,binding
R10977	T22011	T22010	themeOf	activation,mediated
R10978	T22015	T22016	causeOf	binding,inhibits
R10979	T22017	T22016	causeOf	binding,inhibits
R10980	T22021	T22022	themeOf	activation,in response to
R10981	T22025	T22024	themeOf	expression,Increased
R10982	T22029	T22028	themeOf	expression,defective
R10983	T22038	T22043	themeOf	induced,diminished
R10984	T22038	T22040	themeOf	induced,inhibited
R10985	T22039	T22038	themeOf	activation,induced
R10986	T22039	T22040	themeOf	activation,inhibited
R10987	T22041	T22040	causeOf	induction,inhibited
R10988	T22042	T22043	themeOf	induced,diminished
R10989	T22044	T22043	causeOf	induction,diminished

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PMC:1064873 / 23422-34571 JSON TXT