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IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T14767","span":{"begin":204,"end":217},"obj":"Antecedent"},{"id":"T14766","span":{"begin":168,"end":175},"obj":"Antecedent"},{"id":"T14765","span":{"begin":117,"end":129},"obj":"Anaphor"}],"relations":[{"id":"R7449","pred":"boundBy","subj":"T14765","obj":"T14766"},{"id":"R7450","pred":"boundBy","subj":"T14765","obj":"T14767"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T14768","span":{"begin":37,"end":44},"obj":"Protein"},{"id":"T14782","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T14781","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14780","span":{"begin":629,"end":632},"obj":"Protein"},{"id":"T14779","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14778","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T14777","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14776","span":{"begin":361,"end":364},"obj":"Protein"},{"id":"T14775","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14774","span":{"begin":289,"end":294},"obj":"Protein"},{"id":"T14773","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14772","span":{"begin":204,"end":217},"obj":"Protein"},{"id":"T14771","span":{"begin":168,"end":175},"obj":"Protein"},{"id":"T14770","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14769","span":{"begin":51,"end":54},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T14820","span":{"begin":209,"end":213},"obj":"http://www.uniprot.org/uniprot/P60568"},{"id":"T14819","span":{"begin":796,"end":801},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T14818","span":{"begin":338,"end":343},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T14817","span":{"begin":289,"end":294},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T14816","span":{"begin":99,"end":104},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T14815","span":{"begin":821,"end":824},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T14814","span":{"begin":629,"end":632},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T14813","span":{"begin":459,"end":462},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T14812","span":{"begin":361,"end":364},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T14811","span":{"begin":51,"end":54},"obj":"http://www.uniprot.org/uniprot/P01730"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"GO-BP","denotations":[{"id":"T14740","span":{"begin":772,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T14739","span":{"begin":765,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0036499"},{"id":"T14738","span":{"begin":765,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0036500"},{"id":"T14737","span":{"begin":765,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0036498"},{"id":"T14736","span":{"begin":765,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T14735","span":{"begin":765,"end":771},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14734","span":{"begin":751,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_1902531"},{"id":"T14733","span":{"begin":751,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_1902532"},{"id":"T14732","span":{"begin":751,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0035556"},{"id":"T14731","span":{"begin":751,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_1902533"},{"id":"T14730","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071353"},{"id":"T14729","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071352"},{"id":"T14728","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071351"},{"id":"T14727","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071349"},{"id":"T14726","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0097398"},{"id":"T14725","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0097397"},{"id":"T14724","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071348"},{"id":"T14723","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0036016"},{"id":"T14722","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0035963"},{"id":"T14721","span":{"begin":267,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0071350"},{"id":"T14720","span":{"begin":267,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0007349"},{"id":"T14719","span":{"begin":211,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0004920"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"GO-CC","denotations":[{"id":"T14810","span":{"begin":751,"end":764},"obj":"http://purl.obolibrary.org/obo/GO_0005622"},{"id":"T14809","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0045323"},{"id":"T14808","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0072536"},{"id":"T14807","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005893"},{"id":"T14806","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0042022"},{"id":"T14805","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0032002"},{"id":"T14804","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0045092"},{"id":"T14803","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0016516"},{"id":"T14802","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0030876"},{"id":"T14801","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005897"},{"id":"T14800","span":{"begin":79,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005895"},{"id":"T14799","span":{"begin":79,"end":95},"obj":"http://purl.obolibrary.org/obo/GO_0043235"},{"id":"T14798","span":{"begin":418,"end":430},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T14797","span":{"begin":24,"end":36},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T14796","span":{"begin":828,"end":833},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14795","span":{"begin":636,"end":641},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14794","span":{"begin":466,"end":471},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14793","span":{"begin":418,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14792","span":{"begin":24,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"GO-MF","denotations":[{"id":"T14791","span":{"begin":219,"end":225},"obj":"http://purl.obolibrary.org/obo/GO_0005149"},{"id":"T14790","span":{"begin":211,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0004920"},{"id":"T14789","span":{"begin":209,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0005134"},{"id":"T14788","span":{"begin":150,"end":157},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T14787","span":{"begin":143,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T14786","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T14785","span":{"begin":338,"end":343},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T14784","span":{"begin":289,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T14783","span":{"begin":99,"end":104},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"sentences","denotations":[{"id":"T14718","span":{"begin":720,"end":847},"obj":"Sentence"},{"id":"T14717","span":{"begin":566,"end":719},"obj":"Sentence"},{"id":"T14716","span":{"begin":301,"end":565},"obj":"Sentence"},{"id":"T14715","span":{"begin":223,"end":300},"obj":"Sentence"},{"id":"T14714","span":{"begin":64,"end":222},"obj":"Sentence"},{"id":"T14713","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T103","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T104","span":{"begin":64,"end":222},"obj":"Sentence"},{"id":"T105","span":{"begin":223,"end":300},"obj":"Sentence"},{"id":"T106","span":{"begin":301,"end":565},"obj":"Sentence"},{"id":"T107","span":{"begin":566,"end":719},"obj":"Sentence"},{"id":"T108","span":{"begin":720,"end":847},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"simple1","denotations":[{"id":"T14854","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T14853","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14852","span":{"begin":629,"end":632},"obj":"Protein"},{"id":"T14851","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14850","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T14849","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14848","span":{"begin":361,"end":364},"obj":"Protein"},{"id":"T14847","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14846","span":{"begin":289,"end":294},"obj":"Protein"},{"id":"T14845","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14844","span":{"begin":204,"end":217},"obj":"Protein"},{"id":"T14843","span":{"begin":168,"end":175},"obj":"Protein"},{"id":"T14842","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14841","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14840","span":{"begin":37,"end":44},"obj":"Protein"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

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expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T14839","span":{"begin":821,"end":825},"obj":"Protein"},{"id":"T14838","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14837","span":{"begin":660,"end":669},"obj":"Positive_regulation"},{"id":"T14836","span":{"begin":615,"end":625},"obj":"Gene_expression"},{"id":"T14835","span":{"begin":629,"end":633},"obj":"Protein"},{"id":"T14834","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14833","span":{"begin":578,"end":581},"obj":"Protein"},{"id":"T14832","span":{"begin":431,"end":441},"obj":"Gene_expression"},{"id":"T14831","span":{"begin":344,"end":354},"obj":"Negative_regulation"},{"id":"T14830","span":{"begin":456,"end":462},"obj":"Protein"},{"id":"T14829","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14828","span":{"begin":358,"end":364},"obj":"Protein"},{"id":"T14827","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14826","span":{"begin":231,"end":241},"obj":"Gene_expression"},{"id":"T14825","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14824","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14823","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T14822","span":{"begin":10,"end":20},"obj":"Gene_expression"},{"id":"T14821","span":{"begin":48,"end":63},"obj":"Protein"}],"relations":[{"id":"R7451","pred":"themeOf","subj":"T14821","obj":"T14822"},{"id":"R7452","pred":"themeOf","subj":"T14822","obj":"T14823"},{"id":"R7453","pred":"themeOf","subj":"T14825","obj":"T14826"},{"id":"R7454","pred":"themeOf","subj":"T14827","obj":"T14831"},{"id":"R7455","pred":"themeOf","subj":"T14829","obj":"T14832"},{"id":"R7456","pred":"themeOf","subj":"T14834","obj":"T14836"},{"id":"R7457","pred":"themeOf","subj":"T14836","obj":"T14837"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"test3","denotations":[{"id":"T14537","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T14536","span":{"begin":809,"end":817},"obj":"Negative_regulation"},{"id":"T14535","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14534","span":{"begin":660,"end":669},"obj":"Positive_regulation"},{"id":"T14533","span":{"begin":629,"end":632},"obj":"Protein"},{"id":"T14532","span":{"begin":615,"end":625},"obj":"Gene_expression"},{"id":"T14531","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14530","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T14529","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14528","span":{"begin":431,"end":441},"obj":"Gene_expression"},{"id":"T14527","span":{"begin":361,"end":364},"obj":"Protein"},{"id":"T14526","span":{"begin":344,"end":354},"obj":"Negative_regulation"},{"id":"T14525","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14524","span":{"begin":289,"end":294},"obj":"Protein"},{"id":"T14523","span":{"begin":231,"end":241},"obj":"Gene_expression"},{"id":"T14522","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14521","span":{"begin":204,"end":217},"obj":"Protein"},{"id":"T14520","span":{"begin":168,"end":175},"obj":"Protein"},{"id":"T14519","span":{"begin":150,"end":157},"obj":"Binding"},{"id":"T14518","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14517","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14516","span":{"begin":37,"end":44},"obj":"Protein"},{"id":"T14515","span":{"begin":10,"end":20},"obj":"Gene_expression"},{"id":"T14514","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T14513","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T14512","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14511","span":{"begin":629,"end":632},"obj":"Protein"},{"id":"T14510","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14509","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T14508","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14507","span":{"begin":361,"end":364},"obj":"Protein"},{"id":"T14506","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14505","span":{"begin":289,"end":294},"obj":"Protein"},{"id":"T14504","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14503","span":{"begin":204,"end":217},"obj":"Protein"},{"id":"T14502","span":{"begin":168,"end":175},"obj":"Protein"},{"id":"T14501","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14500","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14499","span":{"begin":37,"end":44},"obj":"Protein"}],"relations":[{"id":"R7431","pred":"themeOf","subj":"T14515","obj":"T14514"},{"id":"R7432","pred":"themeOf","subj":"T14516","obj":"T14515"},{"id":"R7433","pred":"themeOf","subj":"T14520","obj":"T14519"},{"id":"R7434","pred":"themeOf","subj":"T14521","obj":"T14519"},{"id":"R7435","pred":"themeOf","subj":"T14522","obj":"T14523"},{"id":"R7436","pred":"themeOf","subj":"T14525","obj":"T14526"},{"id":"R7437","pred":"themeOf","subj":"T14529","obj":"T14528"},{"id":"R7438","pred":"themeOf","subj":"T14531","obj":"T14532"},{"id":"R7439","pred":"themeOf","subj":"T14532","obj":"T14534"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}

{"project":"testone","denotations":[{"id":"T14469","span":{"begin":338,"end":343},"obj":"Protein"},{"id":"T14468","span":{"begin":289,"end":294},"obj":"Protein"},{"id":"T14467","span":{"begin":223,"end":230},"obj":"Protein"},{"id":"T14466","span":{"begin":204,"end":217},"obj":"Protein"},{"id":"T14465","span":{"begin":168,"end":175},"obj":"Protein"},{"id":"T14464","span":{"begin":99,"end":104},"obj":"Protein"},{"id":"T14463","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14462","span":{"begin":37,"end":44},"obj":"Protein"},{"id":"T14486","span":{"begin":809,"end":817},"obj":"Negative_regulation"},{"id":"T14485","span":{"begin":660,"end":669},"obj":"Positive_regulation"},{"id":"T14484","span":{"begin":615,"end":625},"obj":"Gene_expression"},{"id":"T14483","span":{"begin":431,"end":441},"obj":"Gene_expression"},{"id":"T14482","span":{"begin":402,"end":412},"obj":"Gene_expression"},{"id":"T14481","span":{"begin":344,"end":354},"obj":"Negative_regulation"},{"id":"T14480","span":{"begin":231,"end":241},"obj":"Gene_expression"},{"id":"T14479","span":{"begin":150,"end":157},"obj":"Binding"},{"id":"T14478","span":{"begin":10,"end":20},"obj":"Gene_expression"},{"id":"T14477","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T14476","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T14475","span":{"begin":796,"end":801},"obj":"Protein"},{"id":"T14474","span":{"begin":629,"end":632},"obj":"Protein"},{"id":"T14473","span":{"begin":607,"end":614},"obj":"Protein"},{"id":"T14472","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T14471","span":{"begin":445,"end":452},"obj":"Protein"},{"id":"T14470","span":{"begin":361,"end":364},"obj":"Protein"}],"relations":[{"id":"R7424","pred":"themeOf","subj":"T14462","obj":"T14478"},{"id":"R7425","pred":"themeOf","subj":"T14467","obj":"T14480"},{"id":"R7426","pred":"themeOf","subj":"T14469","obj":"T14481"},{"id":"R7427","pred":"themeOf","subj":"T14471","obj":"T14482"},{"id":"R7428","pred":"themeOf","subj":"T14471","obj":"T14483"},{"id":"R7429","pred":"themeOf","subj":"T14473","obj":"T14484"},{"id":"R7430","pred":"themeOf","subj":"T14484","obj":"T14485"}],"text":"Increased expression of cell surface IL-10R1 on RA CD4+ T cells\nThe functional receptor complex of IL-10 consists of two subunits, the primary ligand-binding component IL-10R1 and the accessory component type 2 IL-10R [1]. IL-10R1 expression plays a critical role in cellular responses to IL-10 [29]. To examine whether the resistance to IL-10 inhibition in RA CD4+ T cells was due to limited receptor expression, the cell surface expression of IL-10R1 on PB CD4+ T cells from active RA patients and from healthy controls was determined by flow cytometric analysis. As shown in Fig. 3a,3b, the intensity of IL-10R1 expression on CD4+ T cells was significantly increased in RA patients compared with in healthy controls. These results suggest that the intracellular signal transduction pathway of IL-10 may be impaired in CD4+ T cells of active RA."}