PMC:1064873 / 16823-17327
Annnotations
LappsTest
{"project":"LappsTest","denotations":[{"id":"T12196","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T12201","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T12200","span":{"begin":400,"end":407},"obj":"Protein"},{"id":"T12199","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T12198","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T12197","span":{"begin":44,"end":48},"obj":"Protein"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
biosemtest
{"project":"biosemtest","denotations":[{"id":"T12795","span":{"begin":188,"end":203},"obj":"UMLS/C1819447"},{"id":"T12794","span":{"begin":40,"end":55},"obj":"UMLS/C1819447"},{"id":"T12785","span":{"begin":86,"end":90},"obj":"UMLS/C1332709"},{"id":"T12780","span":{"begin":337,"end":345},"obj":"UMLS/C2587213"},{"id":"T12779","span":{"begin":167,"end":175},"obj":"UMLS/C2587213"},{"id":"T12766","span":{"begin":226,"end":231},"obj":"UMLS/C0439275"},{"id":"T12755","span":{"begin":72,"end":77},"obj":"UMLS/C0231290"},{"id":"T12751","span":{"begin":395,"end":402},"obj":"UMLS/C1546471"},{"id":"T12748","span":{"begin":86,"end":90},"obj":"UMLS/C1426202"},{"id":"T12743","span":{"begin":208,"end":211},"obj":"UMLS/C1518422"},{"id":"T12742","span":{"begin":337,"end":345},"obj":"UMLS/C0332298"},{"id":"T12741","span":{"begin":167,"end":175},"obj":"UMLS/C0332298"},{"id":"T12735","span":{"begin":244,"end":252},"obj":"UMLS/C1705908"},{"id":"T12734","span":{"begin":143,"end":151},"obj":"UMLS/C1705908"},{"id":"T12719","span":{"begin":395,"end":402},"obj":"UMLS/C0332294"},{"id":"T12718","span":{"begin":395,"end":402},"obj":"UMLS/C1274040"},{"id":"T12706","span":{"begin":265,"end":273},"obj":"UMLS/C0205216"},{"id":"T12704","span":{"begin":254,"end":264},"obj":"UMLS/C0439165"},{"id":"T12696","span":{"begin":337,"end":345},"obj":"UMLS/C0243148"},{"id":"T12695","span":{"begin":167,"end":175},"obj":"UMLS/C0243148"},{"id":"T12680","span":{"begin":244,"end":252},"obj":"UMLS/C1550655"},{"id":"T12679","span":{"begin":143,"end":151},"obj":"UMLS/C1550655"},{"id":"T12669","span":{"begin":373,"end":378},"obj":"UMLS/C1515187"},{"id":"T12668","span":{"begin":337,"end":345},"obj":"UMLS/C1547100"},{"id":"T12667","span":{"begin":167,"end":175},"obj":"UMLS/C1547100"},{"id":"T12648","span":{"begin":112,"end":120},"obj":"UMLS/C0150312"},{"id":"T12643","span":{"begin":78,"end":81},"obj":"UMLS/C2698592"},{"id":"T12639","span":{"begin":5,"end":8},"obj":"UMLS/C0349966"},{"id":"T12635","span":{"begin":133,"end":139},"obj":"UMLS/C1553875"},{"id":"T12533","span":{"begin":491,"end":496},"obj":"UMLS/C1334098"},{"id":"T12532","span":{"begin":232,"end":237},"obj":"UMLS/C1334098"},{"id":"T12531","span":{"begin":124,"end":129},"obj":"UMLS/C1334098"},{"id":"T12515","span":{"begin":254,"end":264},"obj":"UMLS/C1549488"},{"id":"T12510","span":{"begin":379,"end":387},"obj":"UMLS/C1883357"},{"id":"T12509","span":{"begin":337,"end":345},"obj":"UMLS/C0009932"},{"id":"T12508","span":{"begin":167,"end":175},"obj":"UMLS/C0009932"},{"id":"T12503","span":{"begin":265,"end":273},"obj":"UMLS/C0547047"},{"id":"T12498","span":{"begin":244,"end":252},"obj":"UMLS/C0030705"},{"id":"T12497","span":{"begin":143,"end":151},"obj":"UMLS/C0030705"},{"id":"T12493","span":{"begin":112,"end":120},"obj":"UMLS/C0392148"},{"id":"T12483","span":{"begin":212,"end":220},"obj":"UMLS/C1314939"},{"id":"T12482","span":{"begin":244,"end":252},"obj":"UMLS/C1578479"},{"id":"T12481","span":{"begin":143,"end":151},"obj":"UMLS/C1578479"},{"id":"T12476","span":{"begin":244,"end":252},"obj":"UMLS/C1578483"},{"id":"T12475","span":{"begin":143,"end":151},"obj":"UMLS/C1578483"},{"id":"T12471","span":{"begin":244,"end":252},"obj":"UMLS/C1578480"},{"id":"T12470","span":{"begin":143,"end":151},"obj":"UMLS/C1578480"},{"id":"T12466","span":{"begin":244,"end":252},"obj":"UMLS/C1578481"},{"id":"T12465","span":{"begin":143,"end":151},"obj":"UMLS/C1578481"},{"id":"T12461","span":{"begin":78,"end":81},"obj":"UMLS/C0108779"},{"id":"T12459","span":{"begin":244,"end":252},"obj":"UMLS/C1578486"},{"id":"T12458","span":{"begin":143,"end":151},"obj":"UMLS/C1578486"},{"id":"T12454","span":{"begin":244,"end":252},"obj":"UMLS/C1578484"},{"id":"T12453","span":{"begin":143,"end":151},"obj":"UMLS/C1578484"},{"id":"T12452","span":{"begin":143,"end":151},"obj":"UMLS/C1578485"},{"id":"T12448","span":{"begin":254,"end":264},"obj":"UMLS/C1561533"},{"id":"T12440","span":{"begin":133,"end":139},"obj":"UMLS/C1561511"},{"id":"T12437","span":{"begin":244,"end":252},"obj":"UMLS/C1578485"},{"id":"T12432","span":{"begin":403,"end":411},"obj":"UMLS/C1444656"},{"id":"T12422","span":{"begin":133,"end":139},"obj":"UMLS/C0205177"},{"id":"T12407","span":{"begin":133,"end":139},"obj":"UMLS/C2347179"},{"id":"T12401","span":{"begin":491,"end":496},"obj":"UMLS/C0085295"},{"id":"T12400","span":{"begin":232,"end":237},"obj":"UMLS/C0085295"},{"id":"T12399","span":{"begin":124,"end":129},"obj":"UMLS/C0085295"},{"id":"T12385","span":{"begin":318,"end":325},"obj":"UMLS/C0392756"},{"id":"T12384","span":{"begin":265,"end":273},"obj":"UMLS/C0392756"},{"id":"T12378","span":{"begin":457,"end":459},"obj":"UMLS/C0319022"},{"id":"T12368","span":{"begin":212,"end":220},"obj":"UMLS/C0392760"},{"id":"T12364","span":{"begin":10,"end":12},"obj":"UMLS/C1553634"},{"id":"T12362","span":{"begin":133,"end":139},"obj":"UMLS/C1561512"},{"id":"T12355","span":{"begin":133,"end":139},"obj":"UMLS/C1561510"},{"id":"T12354","span":{"begin":133,"end":139},"obj":"UMLS/C1561513"},{"id":"T12345","span":{"begin":133,"end":139},"obj":"UMLS/C1561509"},{"id":"T12339","span":{"begin":133,"end":139},"obj":"UMLS/C1561508"},{"id":"T12332","span":{"begin":133,"end":139},"obj":"UMLS/C1561507"},{"id":"T12319","span":{"begin":133,"end":139},"obj":"UMLS/C1547419"},{"id":"T12629","span":{"begin":265,"end":273},"obj":"UMLS/C0442797"},{"id":"T12627","span":{"begin":18,"end":26},"obj":"UMLS/C1883712"},{"id":"T12626","span":{"begin":425,"end":432},"obj":"UMLS/C0039194"},{"id":"T12625","span":{"begin":64,"end":71},"obj":"UMLS/C0039194"},{"id":"T12613","span":{"begin":373,"end":378},"obj":"UMLS/C1883727"},{"id":"T12607","span":{"begin":86,"end":90},"obj":"UMLS/C0075747"},{"id":"T12602","span":{"begin":31,"end":39},"obj":"UMLS/C1707455"},{"id":"T12598","span":{"begin":337,"end":345},"obj":"UMLS/C1550141"},{"id":"T12597","span":{"begin":167,"end":175},"obj":"UMLS/C1550141"},{"id":"T12589","span":{"begin":491,"end":496},"obj":"UMLS/C1149215"},{"id":"T12588","span":{"begin":232,"end":237},"obj":"UMLS/C1149215"},{"id":"T12587","span":{"begin":124,"end":129},"obj":"UMLS/C1149215"},{"id":"T12575","span":{"begin":10,"end":12},"obj":"UMLS/C0450353"},{"id":"T12563","span":{"begin":481,"end":487},"obj":"UMLS/C2348382"},{"id":"T12560","span":{"begin":445,"end":456},"obj":"UMLS/C0231204"},{"id":"T12555","span":{"begin":395,"end":402},"obj":"UMLS/C1280519"},{"id":"T12552","span":{"begin":481,"end":487},"obj":"UMLS/C1280500"},{"id":"T12547","span":{"begin":212,"end":220},"obj":"UMLS/C0001721"},{"id":"T12546","span":{"begin":72,"end":77},"obj":"UMLS/C0687676"},{"id":"T12544","span":{"begin":491,"end":496},"obj":"UMLS/C1522550"},{"id":"T12543","span":{"begin":232,"end":237},"obj":"UMLS/C1522550"},{"id":"T12542","span":{"begin":124,"end":129},"obj":"UMLS/C1522550"},{"id":"T12310","span":{"begin":337,"end":345},"obj":"UMLS/C1882979"},{"id":"T12309","span":{"begin":167,"end":175},"obj":"UMLS/C1882979"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
pmc-enju-pas
{"project":"pmc-enju-pas","denotations":[{"id":"T13584","span":{"begin":498,"end":503},"obj":"NN"},{"id":"T13583","span":{"begin":491,"end":497},"obj":"JJ"},{"id":"T13582","span":{"begin":487,"end":490},"obj":"DT"},{"id":"T13581","span":{"begin":480,"end":486},"obj":"IN"},{"id":"T13580","span":{"begin":474,"end":479},"obj":"NN"},{"id":"T13579","span":{"begin":471,"end":473},"obj":"IN"},{"id":"T13578","span":{"begin":464,"end":470},"obj":"NN"},{"id":"T13577","span":{"begin":447,"end":463},"obj":"JJ"},{"id":"T13576","span":{"begin":443,"end":446},"obj":"DT"},{"id":"T13575","span":{"begin":440,"end":442},"obj":"TO"},{"id":"T13574","span":{"begin":428,"end":439},"obj":"JJ"},{"id":"T13573","span":{"begin":423,"end":427},"obj":"RB"},{"id":"T13572","span":{"begin":416,"end":422},"obj":"VB"},{"id":"T13571","span":{"begin":410,"end":415},"obj":"NN"},{"id":"T13570","span":{"begin":408,"end":409},"obj":"NN"},{"id":"T13569","span":{"begin":403,"end":407},"obj":"JJ"},{"id":"T13568","span":{"begin":400,"end":402},"obj":"NN"},{"id":"T13567","span":{"begin":395,"end":399},"obj":"IN"},{"id":"T13566","span":{"begin":386,"end":394},"obj":"VB"},{"id":"T13565","span":{"begin":378,"end":385},"obj":"NN"},{"id":"T13564","span":{"begin":372,"end":377},"obj":"DT"},{"id":"T13563","span":{"begin":370,"end":371},"obj":"-COMMA-"},{"id":"T13562","span":{"begin":362,"end":370},"obj":"RB"},{"id":"T13561","span":{"begin":356,"end":361},"obj":"VB"},{"id":"T13560","span":{"begin":353,"end":354},"obj":"-RRB-"},{"id":"T13559","span":{"begin":349,"end":353},"obj":"CD"},{"id":"T13558","span":{"begin":347,"end":348},"obj":"SYM"},{"id":"T13557","span":{"begin":345,"end":346},"obj":"NN"},{"id":"T13556","span":{"begin":343,"end":344},"obj":"-COLON-"},{"id":"T13555","span":{"begin":342,"end":343},"obj":"NN"},{"id":"T13554","span":{"begin":338,"end":342},"obj":"CD"},{"id":"T13553","span":{"begin":336,"end":337},"obj":"SYM"},{"id":"T13552","span":{"begin":331,"end":335},"obj":"CD"},{"id":"T13551","span":{"begin":330,"end":331},"obj":"-LRB-"},{"id":"T13550","span":{"begin":321,"end":329},"obj":"NN"},{"id":"T13549","span":{"begin":313,"end":320},"obj":"JJ"},{"id":"T13548","span":{"begin":310,"end":312},"obj":"IN"},{"id":"T13547","span":{"begin":302,"end":309},"obj":"VB"},{"id":"T13546","span":{"begin":288,"end":301},"obj":"RB"},{"id":"T13545","span":{"begin":284,"end":287},"obj":"VB"},{"id":"T13544","span":{"begin":281,"end":283},"obj":"PRP"},{"id":"T13543","span":{"begin":275,"end":280},"obj":"IN"},{"id":"T13542","span":{"begin":273,"end":274},"obj":"-COMMA-"},{"id":"T13541","span":{"begin":272,"end":273},"obj":"-RRB-"},{"id":"T13540","span":{"begin":271,"end":272},"obj":"NN"},{"id":"T13539","span":{"begin":267,"end":271},"obj":"CD"},{"id":"T13538","span":{"begin":265,"end":266},"obj":"-COLON-"},{"id":"T13537","span":{"begin":260,"end":264},"obj":"CD"},{"id":"T13536","span":{"begin":258,"end":259},"obj":"-COMMA-"},{"id":"T13535","span":{"begin":250,"end":258},"obj":"NN"},{"id":"T13534","span":{"begin":239,"end":249},"obj":"NN"},{"id":"T13533","span":{"begin":238,"end":239},"obj":"-LRB-"},{"id":"T13532","span":{"begin":229,"end":237},"obj":"NN"},{"id":"T13531","span":{"begin":226,"end":228},"obj":"NN"},{"id":"T13530","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T13529","span":{"begin":217,"end":222},"obj":"NN"},{"id":"T13528","span":{"begin":211,"end":216},"obj":"NN"},{"id":"T13527","span":{"begin":209,"end":210},"obj":"CD"},{"id":"T13526","span":{"begin":206,"end":208},"obj":"IN"},{"id":"T13525","span":{"begin":197,"end":205},"obj":"VB"},{"id":"T13524","span":{"begin":193,"end":196},"obj":"RB"},{"id":"T13523","span":{"begin":189,"end":192},"obj":"VB"},{"id":"T13522","span":{"begin":178,"end":188},"obj":"NN"},{"id":"T13521","span":{"begin":173,"end":177},"obj":"NN"},{"id":"T13520","span":{"begin":171,"end":172},"obj":"-COMMA-"},{"id":"T13519","span":{"begin":162,"end":171},"obj":"RB"},{"id":"T13518","span":{"begin":152,"end":160},"obj":"NN"},{"id":"T13517","span":{"begin":144,"end":151},"obj":"JJ"},{"id":"T13516","span":{"begin":141,"end":143},"obj":"IN"},{"id":"T13515","span":{"begin":137,"end":140},"obj":"CC"},{"id":"T13514","span":{"begin":128,"end":136},"obj":"NN"},{"id":"T13513","span":{"begin":125,"end":127},"obj":"NN"},{"id":"T13512","span":{"begin":118,"end":124},"obj":"JJ"},{"id":"T13511","span":{"begin":115,"end":117},"obj":"IN"},{"id":"T13510","span":{"begin":109,"end":114},"obj":"NN"},{"id":"T13509","span":{"begin":106,"end":108},"obj":"IN"},{"id":"T13508","span":{"begin":97,"end":105},"obj":"NN"},{"id":"T13507","span":{"begin":93,"end":96},"obj":"DT"},{"id":"T13506","span":{"begin":90,"end":92},"obj":"IN"},{"id":"T13505","span":{"begin":76,"end":89},"obj":"NN"},{"id":"T13504","span":{"begin":71,"end":75},"obj":"NN"},{"id":"T13503","span":{"begin":67,"end":70},"obj":"CC"},{"id":"T13502","span":{"begin":63,"end":66},"obj":"NN"},{"id":"T13501","span":{"begin":57,"end":62},"obj":"IN"},{"id":"T13500","span":{"begin":51,"end":56},"obj":"NN"},{"id":"T13499","span":{"begin":49,"end":50},"obj":"NN"},{"id":"T13498","span":{"begin":44,"end":48},"obj":"JJ"},{"id":"T13497","span":{"begin":41,"end":43},"obj":"IN"},{"id":"T13496","span":{"begin":30,"end":40},"obj":"NN"},{"id":"T13495","span":{"begin":25,"end":29},"obj":"NN"},{"id":"T13494","span":{"begin":16,"end":24},"obj":"VB"},{"id":"T13493","span":{"begin":13,"end":15},"obj":"PRP"},{"id":"T13492","span":{"begin":11,"end":12},"obj":"-COMMA-"},{"id":"T13491","span":{"begin":3,"end":11},"obj":"NN"},{"id":"T13490","span":{"begin":0,"end":2},"obj":"IN"}],"relations":[{"id":"R6758","pred":"arg2Of","subj":"T13491","obj":"T13490"},{"id":"R6759","pred":"arg1Of","subj":"T13493","obj":"T13494"},{"id":"R6760","pred":"arg1Of","subj":"T13494","obj":"T13490"},{"id":"R6761","pred":"arg1Of","subj":"T13494","obj":"T13492"},{"id":"R6762","pred":"arg1Of","subj":"T13494","obj":"T13497"},{"id":"R6763","pred":"arg1Of","subj":"T13494","obj":"T13501"},{"id":"R6764","pred":"arg2Of","subj":"T13496","obj":"T13494"},{"id":"R6765","pred":"arg1Of","subj":"T13496","obj":"T13495"},{"id":"R6766","pred":"arg2Of","subj":"T13500","obj":"T13497"},{"id":"R6767","pred":"arg1Of","subj":"T13500","obj":"T13498"},{"id":"R6768","pred":"arg1Of","subj":"T13500","obj":"T13499"},{"id":"R6769","pred":"arg1Of","subj":"T13502","obj":"T13503"},{"id":"R6770","pred":"arg2Of","subj":"T13504","obj":"T13503"},{"id":"R6771","pred":"arg2Of","subj":"T13505","obj":"T13501"},{"id":"R6772","pred":"arg1Of","subj":"T13505","obj":"T13502"},{"id":"R6773","pred":"arg1Of","subj":"T13505","obj":"T13504"},{"id":"R6774","pred":"arg1Of","subj":"T13505","obj":"T13506"},{"id":"R6775","pred":"arg1Of","subj":"T13505","obj":"T13516"},{"id":"R6776","pred":"arg1Of","subj":"T13506","obj":"T13515"},{"id":"R6777","pred":"arg2Of","subj":"T13508","obj":"T13506"},{"id":"R6778","pred":"arg1Of","subj":"T13508","obj":"T13507"},{"id":"R6779","pred":"arg1Of","subj":"T13508","obj":"T13509"},{"id":"R6780","pred":"arg1Of","subj":"T13508","obj":"T13511"},{"id":"R6781","pred":"arg2Of","subj":"T13510","obj":"T13509"},{"id":"R6782","pred":"arg2Of","subj":"T13514","obj":"T13511"},{"id":"R6783","pred":"arg1Of","subj":"T13514","obj":"T13512"},{"id":"R6784","pred":"arg1Of","subj":"T13514","obj":"T13513"},{"id":"R6785","pred":"arg2Of","subj":"T13516","obj":"T13515"},{"id":"R6786","pred":"arg2Of","subj":"T13518","obj":"T13516"},{"id":"R6787","pred":"arg1Of","subj":"T13518","obj":"T13517"},{"id":"R6788","pred":"arg1Of","subj":"T13522","obj":"T13521"},{"id":"R6789","pred":"arg1Of","subj":"T13522","obj":"T13523"},{"id":"R6790","pred":"arg2Of","subj":"T13522","obj":"T13525"},{"id":"R6791","pred":"arg1Of","subj":"T13525","obj":"T13519"},{"id":"R6792","pred":"arg1Of","subj":"T13525","obj":"T13520"},{"id":"R6793","pred":"arg2Of","subj":"T13525","obj":"T13523"},{"id":"R6794","pred":"arg1Of","subj":"T13525","obj":"T13524"},{"id":"R6795","pred":"arg1Of","subj":"T13525","obj":"T13542"},{"id":"R6796","pred":"arg1Of","subj":"T13525","obj":"T13543"},{"id":"R6797","pred":"arg1Of","subj":"T13527","obj":"T13528"},{"id":"R6798","pred":"arg1Of","subj":"T13529","obj":"T13525"},{"id":"R6799","pred":"arg2Of","subj":"T13529","obj":"T13526"},{"id":"R6800","pred":"arg1Of","subj":"T13529","obj":"T13527"},{"id":"R6801","pred":"arg1Of","subj":"T13529","obj":"T13530"},{"id":"R6802","pred":"arg2Of","subj":"T13532","obj":"T13530"},{"id":"R6803","pred":"arg1Of","subj":"T13532","obj":"T13531"},{"id":"R6804","pred":"arg1Of","subj":"T13532","obj":"T13533"},{"id":"R6805","pred":"arg2Of","subj":"T13535","obj":"T13533"},{"id":"R6806","pred":"arg1Of","subj":"T13535","obj":"T13534"},{"id":"R6807","pred":"arg1Of","subj":"T13535","obj":"T13536"},{"id":"R6808","pred":"arg2Of","subj":"T13540","obj":"T13536"},{"id":"R6809","pred":"arg1Of","subj":"T13540","obj":"T13537"},{"id":"R6810","pred":"arg1Of","subj":"T13540","obj":"T13538"},{"id":"R6811","pred":"arg1Of","subj":"T13540","obj":"T13539"},{"id":"R6812","pred":"arg3Of","subj":"T13541","obj":"T13533"},{"id":"R6813","pred":"arg1Of","subj":"T13544","obj":"T13545"},{"id":"R6814","pred":"arg2Of","subj":"T13544","obj":"T13547"},{"id":"R6815","pred":"arg2Of","subj":"T13547","obj":"T13543"},{"id":"R6816","pred":"arg2Of","subj":"T13547","obj":"T13545"},{"id":"R6817","pred":"arg1Of","subj":"T13547","obj":"T13546"},{"id":"R6818","pred":"arg1Of","subj":"T13547","obj":"T13548"},{"id":"R6819","pred":"arg1Of","subj":"T13547","obj":"T13551"},{"id":"R6820","pred":"arg2Of","subj":"T13550","obj":"T13548"},{"id":"R6821","pred":"arg1Of","subj":"T13550","obj":"T13549"},{"id":"R6822","pred":"arg1Of","subj":"T13554","obj":"T13553"},{"id":"R6823","pred":"arg2Of","subj":"T13555","obj":"T13551"},{"id":"R6824","pred":"arg1Of","subj":"T13555","obj":"T13552"},{"id":"R6825","pred":"arg1Of","subj":"T13555","obj":"T13554"},{"id":"R6826","pred":"arg1Of","subj":"T13555","obj":"T13556"},{"id":"R6827","pred":"arg2Of","subj":"T13557","obj":"T13556"},{"id":"R6828","pred":"arg1Of","subj":"T13557","obj":"T13558"},{"id":"R6829","pred":"arg1Of","subj":"T13557","obj":"T13559"},{"id":"R6830","pred":"arg3Of","subj":"T13560","obj":"T13551"},{"id":"R6831","pred":"arg1Of","subj":"T13561","obj":"T13562"},{"id":"R6832","pred":"arg1Of","subj":"T13565","obj":"T13564"},{"id":"R6833","pred":"arg1Of","subj":"T13565","obj":"T13566"},{"id":"R6834","pred":"modOf","subj":"T13566","obj":"T13561"},{"id":"R6835","pred":"arg1Of","subj":"T13566","obj":"T13563"},{"id":"R6836","pred":"arg1Of","subj":"T13571","obj":"T13568"},{"id":"R6837","pred":"arg1Of","subj":"T13571","obj":"T13569"},{"id":"R6838","pred":"arg1Of","subj":"T13571","obj":"T13570"},{"id":"R6839","pred":"arg1Of","subj":"T13571","obj":"T13572"},{"id":"R6840","pred":"arg1Of","subj":"T13571","obj":"T13574"},{"id":"R6841","pred":"arg2Of","subj":"T13572","obj":"T13566"},{"id":"R6842","pred":"arg1Of","subj":"T13572","obj":"T13567"},{"id":"R6843","pred":"arg1Of","subj":"T13572","obj":"T13581"},{"id":"R6844","pred":"arg2Of","subj":"T13574","obj":"T13572"},{"id":"R6845","pred":"arg1Of","subj":"T13574","obj":"T13573"},{"id":"R6846","pred":"arg1Of","subj":"T13574","obj":"T13575"},{"id":"R6847","pred":"arg2Of","subj":"T13578","obj":"T13575"},{"id":"R6848","pred":"arg1Of","subj":"T13578","obj":"T13576"},{"id":"R6849","pred":"arg1Of","subj":"T13578","obj":"T13577"},{"id":"R6850","pred":"arg1Of","subj":"T13578","obj":"T13579"},{"id":"R6851","pred":"arg2Of","subj":"T13580","obj":"T13579"},{"id":"R6852","pred":"arg2Of","subj":"T13584","obj":"T13581"},{"id":"R6853","pred":"arg1Of","subj":"T13584","obj":"T13582"},{"id":"R6854","pred":"arg1Of","subj":"T13584","obj":"T13583"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T12929","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T12928","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T12927","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T12926","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T12925","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T12924","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T12923","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T12922","span":{"begin":25,"end":29},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T13115","span":{"begin":173,"end":177},"obj":"http://www.uniprot.org/uniprot/P60568"},{"id":"T13114","span":{"begin":25,"end":29},"obj":"http://www.uniprot.org/uniprot/P60568"},{"id":"T13113","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T13110","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T13107","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T13104","span":{"begin":63,"end":66},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T13101","span":{"begin":71,"end":75},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T13096","span":{"begin":403,"end":406},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T13095","span":{"begin":44,"end":47},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T13078","span":{"begin":474,"end":479},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T13077","span":{"begin":217,"end":222},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T13076","span":{"begin":109,"end":114},"obj":"http://www.uniprot.org/uniprot/P22301"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T12824","span":{"begin":173,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0032663"},{"id":"T12823","span":{"begin":25,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0032663"},{"id":"T12822","span":{"begin":173,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0032623"},{"id":"T12821","span":{"begin":25,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0032623"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T12960","span":{"begin":410,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12959","span":{"begin":51,"end":56},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T12950","span":{"begin":173,"end":177},"obj":"http://purl.obolibrary.org/obo/GO_0005134"},{"id":"T12949","span":{"begin":25,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0005134"},{"id":"T12943","span":{"begin":474,"end":479},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T12942","span":{"begin":217,"end":222},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T12941","span":{"begin":109,"end":114},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
sentences
{"project":"sentences","denotations":[{"id":"T12806","span":{"begin":356,"end":504},"obj":"Sentence"},{"id":"T12805","span":{"begin":162,"end":355},"obj":"Sentence"},{"id":"T12804","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T100","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T101","span":{"begin":162,"end":355},"obj":"Sentence"},{"id":"T102","span":{"begin":356,"end":504},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
simple1
{"project":"simple1","denotations":[{"id":"T13156","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T13155","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T13154","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T13153","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T13152","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T13151","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T13150","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T13149","span":{"begin":25,"end":29},"obj":"Protein"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T14405","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T14404","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T14403","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T14391","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T14390","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T14389","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T14388","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T14387","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T14386","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T14385","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T14384","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R7418","pred":"themeOf","subj":"T14384","obj":"T14403"},{"id":"R7419","pred":"themeOf","subj":"T14388","obj":"T14405"},{"id":"R7423","pred":"themeOf","subj":"T14405","obj":"T14404"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T13642","span":{"begin":302,"end":309},"obj":"Negative_regulation"},{"id":"T13641","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T13640","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T13639","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T13625","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T13624","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T13623","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T13622","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T13621","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T13620","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T13619","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T13618","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R6866","pred":"themeOf","subj":"T13618","obj":"T13639"},{"id":"R6867","pred":"themeOf","subj":"T13622","obj":"T13640"},{"id":"R6871","pred":"themeOf","subj":"T13640","obj":"T13642"},{"id":"R6872","pred":"themeOf","subj":"T13640","obj":"T13641"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T14154","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T14153","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T14152","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T14132","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T14131","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T14130","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T14129","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T14128","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T14127","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T14126","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T14125","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R7341","pred":"themeOf","subj":"T14125","obj":"T14152"},{"id":"R7342","pred":"themeOf","subj":"T14129","obj":"T14153"},{"id":"R7343","pred":"causeOf","subj":"T14130","obj":"T14154"},{"id":"R7354","pred":"themeOf","subj":"T14153","obj":"T14154"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T14347","span":{"begin":173,"end":259},"obj":"Regulation"},{"id":"T14345","span":{"begin":173,"end":188},"obj":"Gene_expression"},{"id":"T14344","span":{"begin":0,"end":89},"obj":"Gene_expression"},{"id":"T14343","span":{"begin":71,"end":89},"obj":"Positive_regulation"},{"id":"T14292","span":{"begin":471,"end":479},"obj":"Protein"},{"id":"T14289","span":{"begin":125,"end":127},"obj":"Protein"},{"id":"T14284","span":{"begin":400,"end":415},"obj":"Entity"},{"id":"T14282","span":{"begin":400,"end":402},"obj":"Protein"},{"id":"T14280","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T14275","span":{"begin":63,"end":66},"obj":"Protein"},{"id":"T14331","span":{"begin":206,"end":222},"obj":"Protein"},{"id":"T14317","span":{"begin":226,"end":228},"obj":"Protein"},{"id":"T14311","span":{"begin":331,"end":348},"obj":"Entity"},{"id":"T14310","span":{"begin":41,"end":89},"obj":"Entity"},{"id":"T14307","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T14303","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T14300","span":{"begin":109,"end":160},"obj":"Protein"}],"relations":[{"id":"R7393","pred":"themeOf","subj":"T14280","obj":"T14343"},{"id":"R7397","pred":"themeOf","subj":"T14303","obj":"T14344"},{"id":"R7399","pred":"themeOf","subj":"T14307","obj":"T14345"},{"id":"R7403","pred":"causeOf","subj":"T14331","obj":"T14347"},{"id":"R7407","pred":"themeOf","subj":"T14345","obj":"T14347"}],"attributes":[{"id":"M34","pred":"Negation","subj":"T14347","obj":"true"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
bionlp-st-ge-2016-spacy-parsed
{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T14091","span":{"begin":503,"end":504},"obj":"."},{"id":"T14090","span":{"begin":498,"end":503},"obj":"NN"},{"id":"T14089","span":{"begin":491,"end":497},"obj":"JJ"},{"id":"T14088","span":{"begin":487,"end":490},"obj":"DT"},{"id":"T14087","span":{"begin":480,"end":486},"obj":"IN"},{"id":"T14086","span":{"begin":474,"end":479},"obj":"NN"},{"id":"T14085","span":{"begin":471,"end":473},"obj":"IN"},{"id":"T14084","span":{"begin":464,"end":470},"obj":"NN"},{"id":"T14083","span":{"begin":447,"end":463},"obj":"JJ"},{"id":"T14082","span":{"begin":443,"end":446},"obj":"DT"},{"id":"T14081","span":{"begin":440,"end":442},"obj":"TO"},{"id":"T14080","span":{"begin":428,"end":439},"obj":"JJ"},{"id":"T14079","span":{"begin":423,"end":427},"obj":"RBR"},{"id":"T14078","span":{"begin":416,"end":422},"obj":"VBP"},{"id":"T14077","span":{"begin":410,"end":415},"obj":"NNS"},{"id":"T14076","span":{"begin":408,"end":409},"obj":"NNP"},{"id":"T14075","span":{"begin":406,"end":407},"obj":"VBD"},{"id":"T14074","span":{"begin":403,"end":406},"obj":"NNP"},{"id":"T14073","span":{"begin":400,"end":402},"obj":"NNP"},{"id":"T14072","span":{"begin":395,"end":399},"obj":"IN"},{"id":"T14071","span":{"begin":386,"end":394},"obj":"VBP"},{"id":"T14070","span":{"begin":378,"end":385},"obj":"NNS"},{"id":"T14069","span":{"begin":372,"end":377},"obj":"DT"},{"id":"T14068","span":{"begin":370,"end":371},"obj":","},{"id":"T14067","span":{"begin":362,"end":370},"obj":"RB"},{"id":"T14066","span":{"begin":356,"end":361},"obj":"VBN"},{"id":"T14065","span":{"begin":354,"end":355},"obj":"."},{"id":"T14064","span":{"begin":353,"end":354},"obj":"-RRB-"},{"id":"T14063","span":{"begin":349,"end":353},"obj":"CD"},{"id":"T14062","span":{"begin":347,"end":348},"obj":"NNP"},{"id":"T14061","span":{"begin":345,"end":346},"obj":"NNP"},{"id":"T14060","span":{"begin":343,"end":344},"obj":":"},{"id":"T14059","span":{"begin":342,"end":343},"obj":"NN"},{"id":"T14058","span":{"begin":338,"end":342},"obj":"CD"},{"id":"T14057","span":{"begin":336,"end":337},"obj":"CD"},{"id":"T14056","span":{"begin":331,"end":335},"obj":"CD"},{"id":"T14055","span":{"begin":330,"end":331},"obj":"-LRB-"},{"id":"T14054","span":{"begin":321,"end":329},"obj":"NNS"},{"id":"T14053","span":{"begin":313,"end":320},"obj":"JJ"},{"id":"T14052","span":{"begin":310,"end":312},"obj":"IN"},{"id":"T14051","span":{"begin":302,"end":309},"obj":"VBN"},{"id":"T14050","span":{"begin":288,"end":301},"obj":"RB"},{"id":"T14049","span":{"begin":284,"end":287},"obj":"VBD"},{"id":"T14048","span":{"begin":281,"end":283},"obj":"PRP"},{"id":"T14047","span":{"begin":275,"end":280},"obj":"IN"},{"id":"T14046","span":{"begin":273,"end":274},"obj":","},{"id":"T14045","span":{"begin":272,"end":273},"obj":"-RRB-"},{"id":"T14044","span":{"begin":271,"end":272},"obj":"NN"},{"id":"T14043","span":{"begin":267,"end":271},"obj":"CD"},{"id":"T14042","span":{"begin":265,"end":266},"obj":"NN"},{"id":"T14041","span":{"begin":260,"end":264},"obj":"CD"},{"id":"T14040","span":{"begin":258,"end":259},"obj":","},{"id":"T14039","span":{"begin":250,"end":258},"obj":"NN"},{"id":"T14038","span":{"begin":239,"end":249},"obj":"NN"},{"id":"T14037","span":{"begin":238,"end":239},"obj":"-LRB-"},{"id":"T14036","span":{"begin":229,"end":237},"obj":"NNS"},{"id":"T14035","span":{"begin":226,"end":228},"obj":"NNP"},{"id":"T14034","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T14033","span":{"begin":217,"end":222},"obj":"NN"},{"id":"T14032","span":{"begin":211,"end":216},"obj":"NN"},{"id":"T14031","span":{"begin":209,"end":210},"obj":"CD"},{"id":"T14030","span":{"begin":206,"end":208},"obj":"IN"},{"id":"T14029","span":{"begin":197,"end":205},"obj":"VBN"},{"id":"T14028","span":{"begin":193,"end":196},"obj":"RB"},{"id":"T14027","span":{"begin":189,"end":192},"obj":"VBD"},{"id":"T14026","span":{"begin":178,"end":188},"obj":"NN"},{"id":"T14025","span":{"begin":173,"end":177},"obj":"JJ"},{"id":"T14024","span":{"begin":171,"end":172},"obj":","},{"id":"T14023","span":{"begin":162,"end":171},"obj":"RB"},{"id":"T14022","span":{"begin":160,"end":161},"obj":"."},{"id":"T14021","span":{"begin":152,"end":160},"obj":"NNS"},{"id":"T14020","span":{"begin":144,"end":151},"obj":"JJ"},{"id":"T14019","span":{"begin":141,"end":143},"obj":"IN"},{"id":"T14018","span":{"begin":137,"end":140},"obj":"CC"},{"id":"T14017","span":{"begin":128,"end":136},"obj":"NNS"},{"id":"T14016","span":{"begin":125,"end":127},"obj":"NNP"},{"id":"T14015","span":{"begin":118,"end":124},"obj":"JJ"},{"id":"T14014","span":{"begin":115,"end":117},"obj":"IN"},{"id":"T14013","span":{"begin":109,"end":114},"obj":"NN"},{"id":"T14012","span":{"begin":106,"end":108},"obj":"IN"},{"id":"T14011","span":{"begin":97,"end":105},"obj":"NN"},{"id":"T14010","span":{"begin":93,"end":96},"obj":"DT"},{"id":"T14009","span":{"begin":90,"end":92},"obj":"IN"},{"id":"T14008","span":{"begin":76,"end":89},"obj":"NN"},{"id":"T14007","span":{"begin":71,"end":75},"obj":"NNP"},{"id":"T14006","span":{"begin":67,"end":70},"obj":"CC"},{"id":"T14005","span":{"begin":63,"end":66},"obj":"NNP"},{"id":"T14004","span":{"begin":57,"end":62},"obj":"IN"},{"id":"T14003","span":{"begin":51,"end":56},"obj":"NNS"},{"id":"T14002","span":{"begin":49,"end":50},"obj":"NNP"},{"id":"T14001","span":{"begin":47,"end":48},"obj":"NNP"},{"id":"T14000","span":{"begin":44,"end":47},"obj":"NNP"},{"id":"T13999","span":{"begin":41,"end":43},"obj":"IN"},{"id":"T13998","span":{"begin":30,"end":40},"obj":"NN"},{"id":"T13997","span":{"begin":25,"end":29},"obj":"JJ"},{"id":"T13996","span":{"begin":16,"end":24},"obj":"VBD"},{"id":"T13995","span":{"begin":13,"end":15},"obj":"PRP"},{"id":"T13994","span":{"begin":11,"end":12},"obj":","},{"id":"T13993","span":{"begin":3,"end":11},"obj":"NN"},{"id":"T13992","span":{"begin":0,"end":2},"obj":"IN"}],"relations":[{"id":"R7222","pred":"prep","subj":"T13992","obj":"T13996"},{"id":"R7223","pred":"pobj","subj":"T13993","obj":"T13992"},{"id":"R7224","pred":"punct","subj":"T13994","obj":"T13996"},{"id":"R7225","pred":"nsubj","subj":"T13995","obj":"T13996"},{"id":"R7226","pred":"ROOT","subj":"T13996","obj":"T13996"},{"id":"R7227","pred":"compound","subj":"T13997","obj":"T13998"},{"id":"R7228","pred":"dobj","subj":"T13998","obj":"T13996"},{"id":"R7229","pred":"prep","subj":"T13999","obj":"T13998"},{"id":"R7230","pred":"compound","subj":"T14000","obj":"T14003"},{"id":"R7231","pred":"compound","subj":"T14001","obj":"T14003"},{"id":"R7232","pred":"compound","subj":"T14002","obj":"T14003"},{"id":"R7233","pred":"pobj","subj":"T14003","obj":"T13999"},{"id":"R7234","pred":"prep","subj":"T14004","obj":"T13996"},{"id":"R7235","pred":"nsubj","subj":"T14005","obj":"T14008"},{"id":"R7236","pred":"cc","subj":"T14006","obj":"T14005"},{"id":"R7237","pred":"conj","subj":"T14007","obj":"T14005"},{"id":"R7238","pred":"pobj","subj":"T14008","obj":"T14004"},{"id":"R7239","pred":"prep","subj":"T14009","obj":"T14008"},{"id":"R7240","pred":"det","subj":"T14010","obj":"T14011"},{"id":"R7241","pred":"pobj","subj":"T14011","obj":"T14009"},{"id":"R7242","pred":"prep","subj":"T14012","obj":"T14011"},{"id":"R7243","pred":"pobj","subj":"T14013","obj":"T14012"},{"id":"R7244","pred":"prep","subj":"T14014","obj":"T14013"},{"id":"R7245","pred":"amod","subj":"T14015","obj":"T14017"},{"id":"R7246","pred":"compound","subj":"T14016","obj":"T14017"},{"id":"R7247","pred":"pobj","subj":"T14017","obj":"T14014"},{"id":"R7248","pred":"cc","subj":"T14018","obj":"T14014"},{"id":"R7249","pred":"conj","subj":"T14019","obj":"T14014"},{"id":"R7250","pred":"amod","subj":"T14020","obj":"T14021"},{"id":"R7251","pred":"pobj","subj":"T14021","obj":"T14019"},{"id":"R7252","pred":"punct","subj":"T14022","obj":"T13996"},{"id":"R7253","pred":"advmod","subj":"T14023","obj":"T14029"},{"id":"R7254","pred":"punct","subj":"T14024","obj":"T14029"},{"id":"R7255","pred":"compound","subj":"T14025","obj":"T14026"},{"id":"R7256","pred":"nsubjpass","subj":"T14026","obj":"T14029"},{"id":"R7257","pred":"auxpass","subj":"T14027","obj":"T14029"},{"id":"R7258","pred":"neg","subj":"T14028","obj":"T14029"},{"id":"R7259","pred":"ROOT","subj":"T14029","obj":"T14029"},{"id":"R7260","pred":"agent","subj":"T14030","obj":"T14029"},{"id":"R7261","pred":"nummod","subj":"T14031","obj":"T14033"},{"id":"R7262","pred":"compound","subj":"T14032","obj":"T14033"},{"id":"R7263","pred":"pobj","subj":"T14033","obj":"T14030"},{"id":"R7264","pred":"prep","subj":"T14034","obj":"T14033"},{"id":"R7265","pred":"compound","subj":"T14035","obj":"T14036"},{"id":"R7266","pred":"pobj","subj":"T14036","obj":"T14034"},{"id":"R7267","pred":"punct","subj":"T14037","obj":"T14039"},{"id":"R7268","pred":"compound","subj":"T14038","obj":"T14039"},{"id":"R7269","pred":"appos","subj":"T14039","obj":"T14033"},{"id":"R7270","pred":"punct","subj":"T14040","obj":"T14039"},{"id":"R7271","pred":"nummod","subj":"T14041","obj":"T14042"},{"id":"R7272","pred":"appos","subj":"T14042","obj":"T14039"},{"id":"R7273","pred":"nummod","subj":"T14043","obj":"T14044"},{"id":"R7274","pred":"appos","subj":"T14044","obj":"T14042"},{"id":"R7275","pred":"punct","subj":"T14045","obj":"T14042"},{"id":"R7276","pred":"punct","subj":"T14046","obj":"T14029"},{"id":"R7277","pred":"mark","subj":"T14047","obj":"T14051"},{"id":"R7278","pred":"nsubjpass","subj":"T14048","obj":"T14051"},{"id":"R7279","pred":"auxpass","subj":"T14049","obj":"T14051"},{"id":"R7280","pred":"advmod","subj":"T14050","obj":"T14051"},{"id":"R7281","pred":"advcl","subj":"T14051","obj":"T14029"},{"id":"R7282","pred":"prep","subj":"T14052","obj":"T14051"},{"id":"R7283","pred":"amod","subj":"T14053","obj":"T14054"},{"id":"R7284","pred":"pobj","subj":"T14054","obj":"T14052"},{"id":"R7285","pred":"punct","subj":"T14055","obj":"T14057"},{"id":"R7286","pred":"nummod","subj":"T14056","obj":"T14057"},{"id":"R7287","pred":"dep","subj":"T14057","obj":"T14029"},{"id":"R7288","pred":"nummod","subj":"T14058","obj":"T14059"},{"id":"R7289","pred":"appos","subj":"T14059","obj":"T14057"},{"id":"R7290","pred":"punct","subj":"T14060","obj":"T14062"},{"id":"R7291","pred":"compound","subj":"T14061","obj":"T14062"},{"id":"R7292","pred":"appos","subj":"T14062","obj":"T14057"},{"id":"R7293","pred":"nummod","subj":"T14063","obj":"T14062"},{"id":"R7294","pred":"punct","subj":"T14064","obj":"T14062"},{"id":"R7295","pred":"punct","subj":"T14065","obj":"T14029"},{"id":"R7296","pred":"advcl","subj":"T14066","obj":"T14071"},{"id":"R7297","pred":"advmod","subj":"T14067","obj":"T14066"},{"id":"R7298","pred":"punct","subj":"T14068","obj":"T14071"},{"id":"R7299","pred":"det","subj":"T14069","obj":"T14070"},{"id":"R7300","pred":"nsubj","subj":"T14070","obj":"T14071"},{"id":"R7301","pred":"ROOT","subj":"T14071","obj":"T14071"},{"id":"R7302","pred":"mark","subj":"T14072","obj":"T14078"},{"id":"R7303","pred":"compound","subj":"T14073","obj":"T14074"},{"id":"R7304","pred":"nsubj","subj":"T14074","obj":"T14078"},{"id":"R7305","pred":"amod","subj":"T14075","obj":"T14077"},{"id":"R7306","pred":"compound","subj":"T14076","obj":"T14077"},{"id":"R7307","pred":"nsubj","subj":"T14077","obj":"T14078"},{"id":"R7308","pred":"ccomp","subj":"T14078","obj":"T14071"},{"id":"R7309","pred":"advmod","subj":"T14079","obj":"T14080"},{"id":"R7310","pred":"acomp","subj":"T14080","obj":"T14078"},{"id":"R7311","pred":"prep","subj":"T14081","obj":"T14080"},{"id":"R7312","pred":"det","subj":"T14082","obj":"T14084"},{"id":"R7313","pred":"amod","subj":"T14083","obj":"T14084"},{"id":"R7314","pred":"pobj","subj":"T14084","obj":"T14081"},{"id":"R7315","pred":"prep","subj":"T14085","obj":"T14084"},{"id":"R7316","pred":"pobj","subj":"T14086","obj":"T14085"},{"id":"R7317","pred":"prep","subj":"T14087","obj":"T14084"},{"id":"R7318","pred":"det","subj":"T14088","obj":"T14090"},{"id":"R7319","pred":"amod","subj":"T14089","obj":"T14090"},{"id":"R7320","pred":"pobj","subj":"T14090","obj":"T14087"},{"id":"R7321","pred":"punct","subj":"T14091","obj":"T14071"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T13064","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T13063","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T13062","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T13061","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T13060","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T13059","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T13058","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T13057","span":{"begin":63,"end":66},"obj":"Protein"},{"id":"T13056","span":{"begin":44,"end":48},"obj":"Protein"}],"relations":[{"id":"R6413","pred":"themeOf","subj":"T13060","obj":"T13061"},{"id":"R6414","pred":"themeOf","subj":"T13061","obj":"T13062"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
test3
{"project":"test3","denotations":[{"id":"T12304","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T12303","span":{"begin":464,"end":470},"obj":"Regulation"},{"id":"T12302","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T12301","span":{"begin":302,"end":309},"obj":"Negative_regulation"},{"id":"T12300","span":{"begin":250,"end":258},"obj":"Negative_regulation"},{"id":"T12299","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T12298","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T12297","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T12296","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T12295","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T12294","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T12293","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T12292","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T12291","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T12242","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T12241","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T12240","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T12239","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T12238","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T12237","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T12236","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T12235","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R6350","pred":"themeOf","subj":"T12291","obj":"T12292"},{"id":"R6351","pred":"themeOf","subj":"T12296","obj":"T12297"},{"id":"R6352","pred":"themeOf","subj":"T12297","obj":"T12300"},{"id":"R6353","pred":"themeOf","subj":"T12297","obj":"T12301"},{"id":"R6354","pred":"themeOf","subj":"T12297","obj":"T12298"},{"id":"R6355","pred":"themeOf","subj":"T12298","obj":"T12301"},{"id":"R6356","pred":"causeOf","subj":"T12299","obj":"T12298"},{"id":"R6357","pred":"causeOf","subj":"T12300","obj":"T12298"},{"id":"R6358","pred":"causeOf","subj":"T12304","obj":"T12303"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}
testone
{"project":"testone","denotations":[{"id":"T12174","span":{"begin":464,"end":470},"obj":"Regulation"},{"id":"T12173","span":{"begin":302,"end":309},"obj":"Negative_regulation"},{"id":"T12172","span":{"begin":250,"end":258},"obj":"Negative_regulation"},{"id":"T12171","span":{"begin":197,"end":205},"obj":"Regulation"},{"id":"T12170","span":{"begin":178,"end":188},"obj":"Gene_expression"},{"id":"T12169","span":{"begin":30,"end":40},"obj":"Gene_expression"},{"id":"T12153","span":{"begin":474,"end":479},"obj":"Protein"},{"id":"T12152","span":{"begin":403,"end":406},"obj":"Protein"},{"id":"T12151","span":{"begin":217,"end":222},"obj":"Protein"},{"id":"T12150","span":{"begin":173,"end":177},"obj":"Protein"},{"id":"T12149","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T12148","span":{"begin":71,"end":75},"obj":"Protein"},{"id":"T12147","span":{"begin":44,"end":47},"obj":"Protein"},{"id":"T12146","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R6317","pred":"themeOf","subj":"T12146","obj":"T12169"},{"id":"R6318","pred":"themeOf","subj":"T12150","obj":"T12170"},{"id":"R6319","pred":"causeOf","subj":"T12151","obj":"T12171"},{"id":"R6320","pred":"themeOf","subj":"T12153","obj":"T12174"},{"id":"R6326","pred":"themeOf","subj":"T12170","obj":"T12172"},{"id":"R6327","pred":"themeOf","subj":"T12170","obj":"T12173"},{"id":"R6328","pred":"themeOf","subj":"T12170","obj":"T12171"},{"id":"R6329","pred":"causeOf","subj":"T12172","obj":"T12171"}],"text":"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation in the presence of IL-10 in active RA patients and in healthy controls. Similarly, IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, -2.1 ± 13.8%), while it was significantly reduced in healthy controls (61.1 ± 13.7%; P \u003c 0.05). Taken together, these results indicate that RA CD4+ T cells become less susceptible to the immunoregulatory effect of IL-10 during the active phase."}