PMC:1064873 / 15966-16822 JSON TXT

Annnotations TAB JSON ListView MergeView

LappsTest

{"project":"LappsTest","denotations":[{"id":"T12195","span":{"begin":833,"end":837},"obj":"Protein"},{"id":"T12194","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T12193","span":{"begin":715,"end":719},"obj":"Protein"},{"id":"T12192","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T12191","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T12190","span":{"begin":196,"end":199},"obj":"Protein"},{"id":"T12189","span":{"begin":51,"end":55},"obj":"Protein"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

2_test

{"project":"2_test","denotations":[{"id":"15535835-7306232-4156889","span":{"begin":275,"end":277},"obj":"7306232"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

biosemtest

pmc-enju-pas

bionlp-st-ge-2016-test-proteins

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T12913","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T12912","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T12911","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T12910","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T12909","span":{"begin":31,"end":36},"obj":"Protein"},{"id":"T12921","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T12920","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T12919","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T12918","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T12917","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T12916","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T12915","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T12914","span":{"begin":359,"end":364},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

bionlp-st-ge-2016-uniprot

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T13112","span":{"begin":70,"end":73},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T13109","span":{"begin":70,"end":73},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T13106","span":{"begin":70,"end":73},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T13103","span":{"begin":70,"end":73},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T13100","span":{"begin":78,"end":82},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T13094","span":{"begin":833,"end":836},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T13093","span":{"begin":715,"end":718},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T13092","span":{"begin":51,"end":54},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T13086","span":{"begin":778,"end":783},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T13085","span":{"begin":464,"end":469},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T13073","span":{"begin":384,"end":389},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T13072","span":{"begin":124,"end":129},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T13084","span":{"begin":359,"end":364},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T13083","span":{"begin":31,"end":36},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T13075","span":{"begin":811,"end":816},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T13074","span":{"begin":455,"end":460},"obj":"http://www.uniprot.org/uniprot/P22301"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T12958","span":{"begin":840,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12957","span":{"begin":722,"end":727},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12956","span":{"begin":58,"end":63},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

GO-MF

{"project":"GO-MF","denotations":[{"id":"T12940","span":{"begin":811,"end":816},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T12939","span":{"begin":455,"end":460},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T12938","span":{"begin":384,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T12937","span":{"begin":124,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

sentences

{"project":"sentences","denotations":[{"id":"T12803","span":{"begin":697,"end":856},"obj":"Sentence"},{"id":"T12802","span":{"begin":304,"end":696},"obj":"Sentence"},{"id":"T12801","span":{"begin":0,"end":303},"obj":"Sentence"},{"id":"T97","span":{"begin":0,"end":303},"obj":"Sentence"},{"id":"T98","span":{"begin":304,"end":696},"obj":"Sentence"},{"id":"T99","span":{"begin":697,"end":856},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

simple1

{"project":"simple1","denotations":[{"id":"T13138","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T13137","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T13136","span":{"begin":31,"end":36},"obj":"Protein"},{"id":"T13148","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T13147","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T13146","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T13145","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T13144","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T13143","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T13142","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T13141","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T13140","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T13139","span":{"begin":78,"end":82},"obj":"Protein"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

BioNLP16_DUT

{"project":"BioNLP16_DUT","denotations":[{"id":"T14402","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T14401","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T14400","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T14383","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T14382","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T14381","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T14380","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T14379","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T14378","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T14377","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T14376","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T14375","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T14374","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T14373","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T14372","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14371","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R7415","pred":"themeOf","subj":"T14371","obj":"T14400"},{"id":"R7416","pred":"themeOf","subj":"T14376","obj":"T14401"},{"id":"R7417","pred":"themeOf","subj":"T14379","obj":"T14402"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

BioNLP16_Messiy

{"project":"BioNLP16_Messiy","denotations":[{"id":"T13638","span":{"begin":752,"end":760},"obj":"Gene_expression"},{"id":"T13637","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T13636","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T13635","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T13617","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T13616","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T13615","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T13614","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T13613","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T13612","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T13611","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T13610","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T13609","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T13608","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T13607","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T13606","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T13605","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R6862","pred":"themeOf","subj":"T13605","obj":"T13635"},{"id":"R6863","pred":"themeOf","subj":"T13610","obj":"T13636"},{"id":"R6864","pred":"themeOf","subj":"T13613","obj":"T13637"},{"id":"R6865","pred":"themeOf","subj":"T13615","obj":"T13638"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

DLUT931

{"project":"DLUT931","denotations":[{"id":"T14151","span":{"begin":761,"end":767},"obj":"Positive_regulation"},{"id":"T14150","span":{"begin":752,"end":760},"obj":"Gene_expression"},{"id":"T14149","span":{"begin":344,"end":355},"obj":"Regulation"},{"id":"T14148","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T14147","span":{"begin":445,"end":451},"obj":"Regulation"},{"id":"T14146","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T14145","span":{"begin":83,"end":96},"obj":"Negative_regulation"},{"id":"T14144","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T14124","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T14123","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T14122","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T14121","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T14120","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T14119","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T14118","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T14117","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T14116","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T14115","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T14114","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T14113","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T14112","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R7331","pred":"themeOf","subj":"T14112","obj":"T14144"},{"id":"R7332","pred":"themeOf","subj":"T14114","obj":"T14145"},{"id":"R7333","pred":"themeOf","subj":"T14115","obj":"T14145"},{"id":"R7334","pred":"themeOf","subj":"T14117","obj":"T14146"},{"id":"R7335","pred":"themeOf","subj":"T14118","obj":"T14146"},{"id":"R7336","pred":"themeOf","subj":"T14119","obj":"T14147"},{"id":"R7337","pred":"themeOf","subj":"T14119","obj":"T14148"},{"id":"R7338","pred":"themeOf","subj":"T14120","obj":"T14148"},{"id":"R7339","pred":"themeOf","subj":"T14122","obj":"T14150"},{"id":"R7340","pred":"themeOf","subj":"T14122","obj":"T14151"},{"id":"R7349","pred":"themeOf","subj":"T14146","obj":"T14149"},{"id":"R7350","pred":"themeOf","subj":"T14146","obj":"T14149"},{"id":"R7351","pred":"themeOf","subj":"T14148","obj":"T14147"},{"id":"R7352","pred":"themeOf","subj":"T14148","obj":"T14147"},{"id":"R7353","pred":"themeOf","subj":"T14150","obj":"T14151"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

bionlp-st-ge-2016-test-ihmc

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T14349","span":{"begin":445,"end":480},"obj":"Regulation"},{"id":"T14346","span":{"begin":359,"end":414},"obj":"Gene_expression"},{"id":"T14341","span":{"begin":31,"end":63},"obj":"Gene_expression"},{"id":"T14339","span":{"begin":78,"end":96},"obj":"Positive_regulation"},{"id":"T14338","span":{"begin":461,"end":480},"obj":"Gene_expression"},{"id":"T14337","span":{"begin":445,"end":529},"obj":"Negative_regulation"},{"id":"T14293","span":{"begin":416,"end":419},"obj":"Protein"},{"id":"T14288","span":{"begin":560,"end":562},"obj":"Protein"},{"id":"T14287","span":{"begin":715,"end":751},"obj":"Entity"},{"id":"T14286","span":{"begin":31,"end":36},"obj":"Protein"},{"id":"T14285","span":{"begin":48,"end":63},"obj":"Entity"},{"id":"T14283","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T14281","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T14278","span":{"begin":687,"end":690},"obj":"Protein"},{"id":"T14273","span":{"begin":636,"end":647},"obj":"Protein"},{"id":"T14272","span":{"begin":612,"end":621},"obj":"Protein"},{"id":"T14269","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T14332","span":{"begin":740,"end":742},"obj":"Protein"},{"id":"T14330","span":{"begin":826,"end":845},"obj":"Entity"},{"id":"T14329","span":{"begin":116,"end":144},"obj":"Protein"},{"id":"T14328","span":{"begin":521,"end":523},"obj":"Protein"},{"id":"T14325","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T14323","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T14320","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T14309","span":{"begin":133,"end":135},"obj":"Protein"},{"id":"T14308","span":{"begin":803,"end":816},"obj":"Protein"},{"id":"T14299","span":{"begin":196,"end":199},"obj":"Protein"},{"id":"T14297","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T14296","span":{"begin":452,"end":460},"obj":"Protein"}],"relations":[{"id":"R7392","pred":"themeOf","subj":"T14269","obj":"T14338"},{"id":"R7394","pred":"themeOf","subj":"T14286","obj":"T14341"},{"id":"R7395","pred":"causeOf","subj":"T14296","obj":"T14349"},{"id":"R7396","pred":"themeOf","subj":"T14297","obj":"T14339"},{"id":"R7400","pred":"themeOf","subj":"T14320","obj":"T14346"},{"id":"R7406","pred":"themeOf","subj":"T14338","obj":"T14349"},{"id":"R7408","pred":"themeOf","subj":"T14349","obj":"T14337"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

bionlp-st-ge-2016-spacy-parsed

bionlp-st-ge-2016-test-tees

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T13055","span":{"begin":847,"end":854},"obj":"Protein"},{"id":"T13054","span":{"begin":833,"end":837},"obj":"Protein"},{"id":"T13053","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T13052","span":{"begin":715,"end":719},"obj":"Protein"},{"id":"T13051","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T13050","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T13049","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T13048","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T13047","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T13046","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T13045","span":{"begin":416,"end":423},"obj":"Protein"},{"id":"T13044","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T13043","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T13042","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T13041","span":{"begin":196,"end":199},"obj":"Protein"},{"id":"T13040","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T13039","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T13038","span":{"begin":51,"end":55},"obj":"Protein"},{"id":"T13037","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R6408","pred":"themeOf","subj":"T13037","obj":"T13043"},{"id":"R6409","pred":"themeOf","subj":"T13044","obj":"T13048"},{"id":"R6410","pred":"themeOf","subj":"T13045","obj":"T13049"},{"id":"R6411","pred":"themeOf","subj":"T13046","obj":"T13050"},{"id":"R6412","pred":"themeOf","subj":"T13047","obj":"T13051"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

test3

{"project":"test3","denotations":[{"id":"T12290","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T12289","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T12288","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T12287","span":{"begin":752,"end":760},"obj":"Gene_expression"},{"id":"T12286","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T12285","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T12284","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T12283","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T12282","span":{"begin":445,"end":451},"obj":"Regulation"},{"id":"T12281","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T12280","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T12279","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T12278","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T12277","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T12276","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T12275","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T12274","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T12273","span":{"begin":31,"end":36},"obj":"Protein"},{"id":"T12234","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T12233","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T12232","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T12231","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T12230","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T12229","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T12228","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T12227","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T12226","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T12225","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T12224","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T12223","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T12222","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R6344","pred":"themeOf","subj":"T12273","obj":"T12274"},{"id":"R6345","pred":"themeOf","subj":"T12279","obj":"T12280"},{"id":"R6346","pred":"themeOf","subj":"T12283","obj":"T12285"},{"id":"R6347","pred":"themeOf","subj":"T12284","obj":"T12285"},{"id":"R6348","pred":"themeOf","subj":"T12285","obj":"T12282"},{"id":"R6349","pred":"themeOf","subj":"T12288","obj":"T12287"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

testone

{"project":"testone","denotations":[{"id":"T12168","span":{"begin":761,"end":767},"obj":"Positive_regulation"},{"id":"T12167","span":{"begin":752,"end":760},"obj":"Gene_expression"},{"id":"T12166","span":{"begin":499,"end":506},"obj":"Negative_regulation"},{"id":"T12165","span":{"begin":470,"end":480},"obj":"Gene_expression"},{"id":"T12164","span":{"begin":445,"end":451},"obj":"Regulation"},{"id":"T12163","span":{"begin":434,"end":444},"obj":"Negative_regulation"},{"id":"T12162","span":{"begin":365,"end":375},"obj":"Gene_expression"},{"id":"T12161","span":{"begin":37,"end":47},"obj":"Gene_expression"},{"id":"T12145","span":{"begin":833,"end":836},"obj":"Protein"},{"id":"T12144","span":{"begin":811,"end":816},"obj":"Protein"},{"id":"T12143","span":{"begin":778,"end":783},"obj":"Protein"},{"id":"T12142","span":{"begin":715,"end":718},"obj":"Protein"},{"id":"T12141","span":{"begin":464,"end":469},"obj":"Protein"},{"id":"T12140","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T12139","span":{"begin":384,"end":389},"obj":"Protein"},{"id":"T12138","span":{"begin":359,"end":364},"obj":"Protein"},{"id":"T12137","span":{"begin":124,"end":129},"obj":"Protein"},{"id":"T12136","span":{"begin":78,"end":82},"obj":"Protein"},{"id":"T12135","span":{"begin":70,"end":73},"obj":"Protein"},{"id":"T12134","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T12133","span":{"begin":31,"end":36},"obj":"Protein"}],"relations":[{"id":"R6311","pred":"themeOf","subj":"T12133","obj":"T12161"},{"id":"R6312","pred":"themeOf","subj":"T12138","obj":"T12162"},{"id":"R6313","pred":"themeOf","subj":"T12141","obj":"T12165"},{"id":"R6314","pred":"themeOf","subj":"T12143","obj":"T12167"},{"id":"R6315","pred":"themeOf","subj":"T12143","obj":"T12168"},{"id":"R6316","pred":"causeOf","subj":"T12144","obj":"T12168"},{"id":"R6323","pred":"themeOf","subj":"T12165","obj":"T12166"},{"id":"R6324","pred":"themeOf","subj":"T12165","obj":"T12164"},{"id":"R6325","pred":"themeOf","subj":"T12167","obj":"T12168"}],"text":"We thus compared the levels of IFN-γ production by CD4+ T cells after CD3 and CD28 costimulation in the presence of 1 ng/ml IL-10 in RA patients with active disease (multiple inflammatory joints, CRP level ≥ 10 mg/l) and inactive disease (in remission, CRP level \u003c 10 mg/l) [26] and in healthy controls. There were no statistically significant differences in IFN-γ production without IL-10 among these three groups (Fig. 2a), but the inhibitory effect of IL-10 on IFN-γ production was significantly limited in the active RA group as compared with the inactive RA group and healthy controls (percentage decrease: active RA, 2.9 ± 14.4%; inactive RA, 45.6 ± 14.4%; controls, 65.8 ± 7.9%) (Fig. 2b). As a consequence, CD4+ T cells from active RA patients produced higher levels of IFN-γ in the presence of 1 ng/ml IL-10 than did normal CD4+ T cells (Fig. 2a)."}

PMC:1064873 / 15966-16822 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:1064873 / 15966-16822 JSON TXT