PMC:1064854 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T727	0-3	NN	denotes	PGC
T728	4-6	NN	denotes	1α
T730	3-4	HYPH	denotes	-
T731	7-17	NN	denotes	Deficiency
T732	18-24	VBZ	denotes	Causes
T733	25-37	NN	denotes	Multi-System
T734	55-67	NNS	denotes	Derangements
T735	38-44	NN	denotes	Energy
T736	45-54	JJ	denotes	Metabolic
T737	67-69	:	denotes	:
T738	69-75	NN	denotes	Muscle
T739	76-87	NN	denotes	Dysfunction
T740	87-89	,	denotes	,
T741	89-97	JJ	denotes	Abnormal
T742	105-112	NN	denotes	Control
T743	98-104	NN	denotes	Weight
T744	113-116	CC	denotes	and
T745	117-124	JJ	denotes	Hepatic
T746	125-134	NN	denotes	Steatosis
T747	134-135	sentence	denotes
T748	189-329	sentence	denotes	The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was targeted in mice.
T749	189-192	DT	denotes	The
T750	193-197	NN	denotes	gene
T751	312-320	VBN	denotes	targeted
T752	198-206	VBG	denotes	encoding
T753	207-210	DT	denotes	the
T754	227-238	NN	denotes	coactivator
T755	211-226	JJ	denotes	transcriptional
T756	239-249	NN	denotes	peroxisome
T757	250-262	NN	denotes	proliferator
T758	263-272	VBN	denotes	activated
T759	262-263	HYPH	denotes	-
T760	296-298	NN	denotes	1α
T761	273-281	NN	denotes	receptor
T762	281-282	HYPH	denotes	-
T763	282-283	SYM	denotes	γ
T764	284-295	NN	denotes	coactivator
T765	295-296	HYPH	denotes	-
T766	299-300	-LRB-	denotes	(
T767	300-303	NN	denotes	PGC
T768	304-306	NN	denotes	1α
T769	303-304	HYPH	denotes	-
T770	306-307	-RRB-	denotes	)
T771	308-311	VBD	denotes	was
T772	321-323	IN	denotes	in
T773	324-328	NNS	denotes	mice
T774	328-329	.	denotes	.
T775	329-371	sentence	denotes	PGC-1α null (PGC-1α−/−) mice were viable.
T776	330-333	NN	denotes	PGC
T777	334-336	NN	denotes	1α
T778	333-334	HYPH	denotes	-
T779	337-341	JJ	denotes	null
T780	347-349	NN	denotes	1α
T781	342-343	-LRB-	denotes	(
T782	343-346	NN	denotes	PGC
T783	346-347	HYPH	denotes	-
T784	354-358	NNS	denotes	mice
T785	349-350	SYM	denotes	−
T786	350-351	HYPH	denotes	/
T787	351-352	SYM	denotes	−
T788	352-353	-RRB-	denotes	)
T789	359-363	VBD	denotes	were
T790	364-370	JJ	denotes	viable
T791	370-371	.	denotes	.
T792	371-492	sentence	denotes	However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phenotype.
T793	372-379	RB	denotes	However
T794	403-411	VBD	denotes	revealed
T795	379-381	,	denotes	,
T796	381-390	JJ	denotes	extensive
T797	391-402	NN	denotes	phenotyping
T798	412-424	JJ	denotes	multi-system
T799	425-438	NNS	denotes	abnormalities
T800	439-449	JJ	denotes	indicative
T801	450-452	IN	denotes	of
T802	453-455	DT	denotes	an
T803	482-491	NN	denotes	phenotype
T804	456-464	JJ	denotes	abnormal
T805	465-471	NN	denotes	energy
T806	472-481	JJ	denotes	metabolic
T807	491-492	.	denotes	.
T808	492-632	sentence	denotes	The postnatal growth of heart and slow-twitch skeletal muscle, organs with high mitochondrial energy demands, is blunted in PGC-1α−/− mice.
T809	493-496	DT	denotes	The
T810	507-513	NN	denotes	growth
T811	497-506	JJ	denotes	postnatal
T812	606-613	VBN	denotes	blunted
T813	514-516	IN	denotes	of
T814	517-522	NN	denotes	heart
T815	523-526	CC	denotes	and
T816	527-531	JJ	denotes	slow
T817	532-538	NN	denotes	twitch
T818	531-532	HYPH	denotes	-
T819	548-554	NN	denotes	muscle
T820	539-547	JJ	denotes	skeletal
T821	554-556	,	denotes	,
T822	556-562	NNS	denotes	organs
T823	563-567	IN	denotes	with
T824	568-572	JJ	denotes	high
T825	594-601	NNS	denotes	demands
T826	573-586	JJ	denotes	mitochondrial
T827	587-593	NN	denotes	energy
T828	601-603	,	denotes	,
T829	603-605	VBZ	denotes	is
T830	614-616	IN	denotes	in
T831	617-620	NN	denotes	PGC
T832	621-623	NN	denotes	1α
T833	620-621	HYPH	denotes	-
T834	627-631	NNS	denotes	mice
T835	623-624	SYM	denotes	−
T836	624-625	HYPH	denotes	/
T837	625-626	SYM	denotes	−
T838	631-632	.	denotes	.
T839	632-744	sentence	denotes	With age, the PGC-1α−/− mice develop abnormally increased body fat, a phenotype that is more severe in females.
T840	633-637	IN	denotes	With
T841	662-669	VBP	denotes	develop
T842	638-641	NN	denotes	age
T843	641-643	,	denotes	,
T844	643-646	DT	denotes	the
T845	657-661	NNS	denotes	mice
T846	647-650	NN	denotes	PGC
T847	651-653	NN	denotes	1α
T848	650-651	HYPH	denotes	-
T849	653-654	SYM	denotes	−
T850	654-655	HYPH	denotes	/
T851	655-656	SYM	denotes	−
T852	670-680	RB	denotes	abnormally
T853	681-690	VBN	denotes	increased
T854	696-699	NN	denotes	fat
T855	691-695	NN	denotes	body
T856	699-701	,	denotes	,
T857	701-702	DT	denotes	a
T858	703-712	NN	denotes	phenotype
T859	713-717	WDT	denotes	that
T860	718-720	VBZ	denotes	is
T861	721-725	RBR	denotes	more
T862	726-732	JJ	denotes	severe
T863	733-735	IN	denotes	in
T864	736-743	NNS	denotes	females
T865	743-744	.	denotes	.
T866	744-915	sentence	denotes	Mitochondrial number and respiratory capacity is diminished in slow-twitch skeletal muscle of PGC-1α−/− mice, leading to reduced muscle performance and exercise capacity.
T867	745-758	JJ	denotes	Mitochondrial
T868	759-765	NN	denotes	number
T869	794-804	VBN	denotes	diminished
T870	766-769	CC	denotes	and
T871	770-781	JJ	denotes	respiratory
T872	782-790	NN	denotes	capacity
T873	791-793	VBZ	denotes	is
T874	805-807	IN	denotes	in
T875	808-812	JJ	denotes	slow
T876	813-819	NN	denotes	twitch
T877	812-813	HYPH	denotes	-
T878	829-835	NN	denotes	muscle
T879	820-828	JJ	denotes	skeletal
T880	836-838	IN	denotes	of
T881	839-842	NN	denotes	PGC
T882	843-845	NN	denotes	1α
T883	842-843	HYPH	denotes	-
T884	849-853	NNS	denotes	mice
T885	845-846	SYM	denotes	−
T886	846-847	HYPH	denotes	/
T887	847-848	SYM	denotes	−
T888	853-855	,	denotes	,
T889	855-862	VBG	denotes	leading
T890	863-865	IN	denotes	to
T891	866-873	VBN	denotes	reduced
T892	881-892	NN	denotes	performance
T893	874-880	NN	denotes	muscle
T894	893-896	CC	denotes	and
T895	897-905	NN	denotes	exercise
T896	906-914	NN	denotes	capacity
T897	914-915	.	denotes	.
T898	915-1029	sentence	denotes	PGC-1α−/− mice exhibit a modest diminution in cardiac function related largely to abnormal control of heart rate.
T899	916-919	NN	denotes	PGC
T900	920-922	NN	denotes	1α
T901	919-920	HYPH	denotes	-
T902	926-930	NNS	denotes	mice
T903	922-923	SYM	denotes	−
T904	923-924	HYPH	denotes	/
T905	924-925	SYM	denotes	−
T906	931-938	VBP	denotes	exhibit
T907	939-940	DT	denotes	a
T908	948-958	NN	denotes	diminution
T909	941-947	JJ	denotes	modest
T910	959-961	IN	denotes	in
T911	962-969	JJ	denotes	cardiac
T912	970-978	NN	denotes	function
T913	979-986	VBN	denotes	related
T914	987-994	RB	denotes	largely
T915	995-997	IN	denotes	to
T916	998-1006	JJ	denotes	abnormal
T917	1007-1014	NN	denotes	control
T918	1015-1017	IN	denotes	of
T919	1018-1023	NN	denotes	heart
T920	1024-1028	NN	denotes	rate
T921	1028-1029	.	denotes	.
T922	1029-1171	sentence	denotes	The PGC-1α−/− mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic response.
T923	1030-1033	DT	denotes	The
T924	1044-1048	NNS	denotes	mice
T925	1034-1037	NN	denotes	PGC
T926	1038-1040	NN	denotes	1α
T927	1037-1038	HYPH	denotes	-
T928	1040-1041	SYM	denotes	−
T929	1041-1042	HYPH	denotes	/
T930	1042-1043	SYM	denotes	−
T931	1049-1053	VBD	denotes	were
T932	1054-1060	JJ	denotes	unable
T933	1061-1063	TO	denotes	to
T934	1064-1072	VB	denotes	maintain
T935	1073-1077	NN	denotes	core
T936	1083-1094	NN	denotes	temperature
T937	1078-1082	NN	denotes	body
T938	1095-1104	VBG	denotes	following
T939	1105-1113	NN	denotes	exposure
T940	1114-1116	IN	denotes	to
T941	1117-1121	NN	denotes	cold
T942	1121-1123	,	denotes	,
T943	1123-1133	JJ	denotes	consistent
T944	1134-1138	IN	denotes	with
T945	1139-1141	DT	denotes	an
T946	1162-1170	NN	denotes	response
T947	1142-1149	JJ	denotes	altered
T948	1150-1161	JJ	denotes	thermogenic
T949	1170-1171	.	denotes	.
T950	1171-1360	sentence	denotes	Following short-term starvation, PGC-1α−/− mice develop hepatic steatosis due to a combination of reduced mitochondrial respiratory capacity and an increased expression of lipogenic genes.
T951	1172-1181	VBG	denotes	Following
T952	1220-1227	VBP	denotes	develop
T953	1182-1187	JJ	denotes	short
T954	1188-1192	NN	denotes	term
T955	1187-1188	HYPH	denotes	-
T956	1193-1203	NN	denotes	starvation
T957	1203-1205	,	denotes	,
T958	1205-1208	NN	denotes	PGC
T959	1209-1211	NN	denotes	1α
T960	1208-1209	HYPH	denotes	-
T961	1215-1219	NNS	denotes	mice
T962	1211-1212	SYM	denotes	−
T963	1212-1213	HYPH	denotes	/
T964	1213-1214	SYM	denotes	−
T965	1228-1235	JJ	denotes	hepatic
T966	1236-1245	NN	denotes	steatosis
T967	1246-1249	IN	denotes	due
T968	1250-1252	IN	denotes	to
T969	1253-1254	DT	denotes	a
T970	1255-1266	NN	denotes	combination
T971	1267-1269	IN	denotes	of
T972	1270-1277	VBN	denotes	reduced
T973	1304-1312	NN	denotes	capacity
T974	1278-1291	JJ	denotes	mitochondrial
T975	1292-1303	JJ	denotes	respiratory
T976	1313-1316	CC	denotes	and
T977	1317-1319	DT	denotes	an
T978	1330-1340	NN	denotes	expression
T979	1320-1329	VBN	denotes	increased
T980	1341-1343	IN	denotes	of
T981	1344-1353	JJ	denotes	lipogenic
T982	1354-1359	NNS	denotes	genes
T983	1359-1360	.	denotes	.
T984	1360-1471	sentence	denotes	Surprisingly, PGC-1α−/− mice were less susceptible to diet-induced insulin resistance than wild-type controls.
T985	1361-1373	RB	denotes	Surprisingly
T986	1390-1394	VBD	denotes	were
T987	1373-1375	,	denotes	,
T988	1375-1378	NN	denotes	PGC
T989	1379-1381	NN	denotes	1α
T990	1378-1379	HYPH	denotes	-
T991	1385-1389	NNS	denotes	mice
T992	1381-1382	SYM	denotes	−
T993	1382-1383	HYPH	denotes	/
T994	1383-1384	SYM	denotes	−
T995	1395-1399	RBR	denotes	less
T996	1400-1411	JJ	denotes	susceptible
T997	1412-1414	IN	denotes	to
T998	1415-1419	NN	denotes	diet
T999	1420-1427	VBN	denotes	induced
T1000	1419-1420	HYPH	denotes	-
T1001	1436-1446	NN	denotes	resistance
T1002	1428-1435	NN	denotes	insulin
T1003	1447-1451	IN	denotes	than
T1004	1452-1456	JJ	denotes	wild
T1005	1457-1461	NN	denotes	type
T1006	1456-1457	HYPH	denotes	-
T1007	1462-1470	NNS	denotes	controls
T1008	1470-1471	.	denotes	.
T1009	1471-1559	sentence	denotes	Lastly, vacuolar lesions were detected in the central nervous system of PGC-1α−/− mice.
T1010	1472-1478	RB	denotes	Lastly
T1011	1502-1510	VBN	denotes	detected
T1012	1478-1480	,	denotes	,
T1013	1480-1488	JJ	denotes	vacuolar
T1014	1489-1496	NNS	denotes	lesions
T1015	1497-1501	VBD	denotes	were
T1016	1511-1513	IN	denotes	in
T1017	1514-1517	DT	denotes	the
T1018	1534-1540	NN	denotes	system
T1019	1518-1525	JJ	denotes	central
T1020	1526-1533	JJ	denotes	nervous
T1021	1541-1543	IN	denotes	of
T1022	1544-1547	NN	denotes	PGC
T1023	1548-1550	NN	denotes	1α
T1024	1547-1548	HYPH	denotes	-
T1025	1554-1558	NNS	denotes	mice
T1026	1550-1551	SYM	denotes	−
T1027	1551-1552	HYPH	denotes	/
T1028	1552-1553	SYM	denotes	−
T1029	1558-1559	.	denotes	.
T1030	1559-1699	sentence	denotes	These results demonstrate that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
T1031	1560-1565	DT	denotes	These
T1032	1566-1573	NNS	denotes	results
T1033	1574-1585	VBP	denotes	demonstrate
T1034	1586-1590	IN	denotes	that
T1035	1598-1600	VBZ	denotes	is
T1036	1591-1594	NN	denotes	PGC
T1037	1595-1597	NN	denotes	1α
T1038	1594-1595	HYPH	denotes	-
T1039	1601-1610	JJ	denotes	necessary
T1040	1611-1614	IN	denotes	for
T1041	1615-1626	JJ	denotes	appropriate
T1042	1627-1637	NN	denotes	adaptation
T1043	1638-1640	IN	denotes	to
T1044	1641-1644	DT	denotes	the
T1045	1671-1680	NNS	denotes	stressors
T1046	1645-1654	JJ	denotes	metabolic
T1047	1655-1658	CC	denotes	and
T1048	1659-1670	JJ	denotes	physiologic
T1049	1681-1683	IN	denotes	of
T1050	1684-1693	JJ	denotes	postnatal
T1051	1694-1698	NN	denotes	life
T1052	1698-1699	.	denotes	.
T3560	2334-2335	DT	denotes	a
T3501	1910-1923	JJ	denotes	Mitochondrial
T3502	1935-1943	NN	denotes	capacity
T3503	1924-1934	JJ	denotes	functional
T3504	1959-1968	VBN	denotes	regulated
T3505	1944-1946	VBZ	denotes	is
T3506	1947-1958	RB	denotes	dynamically
T3507	1969-1971	TO	denotes	to
T3508	1972-1976	VB	denotes	meet
T3509	1977-1980	DT	denotes	the
T3510	1996-2003	NNS	denotes	demands
T3511	1981-1988	JJ	denotes	diverse
T3512	1989-1995	NN	denotes	energy
T3513	2004-2011	VBN	denotes	imposed
T3514	2012-2014	IN	denotes	on
T3515	2015-2018	DT	denotes	the
T3516	2029-2037	NN	denotes	organism
T3517	2019-2028	JJ	denotes	mammalian
T3518	2038-2047	VBG	denotes	following
T3519	2048-2053	NN	denotes	birth
T3520	2053-2054	.	denotes	.
T3521	2054-2303	sentence	denotes	Postnatal mitochondrial biogenesis involves multiple signaling and transcriptional regulatory pathways that control the coordinate expression of nuclear and mitochondrial genes involved in mitochondrial structure, metabolism, and proliferation [1].
T3522	2055-2064	JJ	denotes	Postnatal
T3523	2079-2089	NN	denotes	biogenesis
T3524	2065-2078	JJ	denotes	mitochondrial
T3525	2090-2098	VBZ	denotes	involves
T3526	2099-2107	JJ	denotes	multiple
T3527	2149-2157	NNS	denotes	pathways
T3528	2108-2117	NN	denotes	signaling
T3529	2118-2121	CC	denotes	and
T3530	2122-2137	JJ	denotes	transcriptional
T3531	2138-2148	JJ	denotes	regulatory
T3532	2158-2162	WDT	denotes	that
T3533	2163-2170	VBP	denotes	control
T3534	2171-2174	DT	denotes	the
T3535	2186-2196	NN	denotes	expression
T3536	2175-2185	JJ	denotes	coordinate
T3537	2197-2199	IN	denotes	of
T3538	2200-2207	JJ	denotes	nuclear
T3539	2226-2231	NNS	denotes	genes
T3540	2208-2211	CC	denotes	and
T3541	2212-2225	JJ	denotes	mitochondrial
T3542	2232-2240	VBN	denotes	involved
T3543	2241-2243	IN	denotes	in
T3544	2244-2257	JJ	denotes	mitochondrial
T3545	2258-2267	NN	denotes	structure
T3546	2267-2269	,	denotes	,
T3547	2269-2279	NN	denotes	metabolism
T3548	2279-2281	,	denotes	,
T3549	2281-2284	CC	denotes	and
T3550	2285-2298	NN	denotes	proliferation
T3551	2299-2300	-LRB-	denotes	[
T3552	2300-2301	CD	denotes	1
T3553	2301-2302	-RRB-	denotes	]
T3554	2302-2303	.	denotes	.
T3555	2303-2623	sentence	denotes	Recent evidence points toward a transcriptional coactivator, peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α), as an integrator of the molecular regulatory circuitry involved in the transcriptional control of cellular energy metabolism, including mitochondrial function and biogenesis [1,2].
T3556	2304-2310	JJ	denotes	Recent
T3557	2311-2319	NN	denotes	evidence
T3558	2320-2326	VBZ	denotes	points
T3559	2327-2333	IN	denotes	toward
T3561	2352-2363	NN	denotes	coactivator
T3562	2336-2351	JJ	denotes	transcriptional
T3563	2363-2365	,	denotes	,
T3564	2365-2375	NN	denotes	peroxisome
T3565	2376-2388	NN	denotes	proliferator
T3566	2389-2398	VBN	denotes	activated
T3567	2388-2389	HYPH	denotes	-
T3568	2399-2407	NN	denotes	receptor
T3569	2430-2432	NN	denotes	1α
T3570	2407-2408	HYPH	denotes	-
T3571	2408-2409	SYM	denotes	γ
T3572	2410-2411	-LRB-	denotes	(
T3573	2411-2416	NN	denotes	PPARγ
T3574	2416-2417	-RRB-	denotes	)
T3575	2418-2429	NN	denotes	coactivator
T3576	2429-2430	HYPH	denotes	-
T3577	2433-2434	-LRB-	denotes	(
T3578	2434-2437	NN	denotes	PGC
T3579	2438-2440	NN	denotes	1α
T3580	2437-2438	HYPH	denotes	-
T3581	2440-2441	-RRB-	denotes	)
T3582	2441-2443	,	denotes	,
T3583	2443-2445	IN	denotes	as
T3584	2446-2448	DT	denotes	an
T3585	2449-2459	NN	denotes	integrator
T3586	2460-2462	IN	denotes	of
T3587	2463-2466	DT	denotes	the
T3588	2488-2497	NN	denotes	circuitry
T3589	2467-2476	JJ	denotes	molecular
T3590	2477-2487	JJ	denotes	regulatory
T3591	2498-2506	VBN	denotes	involved
T3592	2507-2509	IN	denotes	in
T3593	2510-2513	DT	denotes	the
T3594	2530-2537	NN	denotes	control
T3595	2514-2529	JJ	denotes	transcriptional
T3596	2538-2540	IN	denotes	of
T3597	2541-2549	JJ	denotes	cellular
T3598	2557-2567	NN	denotes	metabolism
T3599	2550-2556	NN	denotes	energy
T3600	2567-2569	,	denotes	,
T3601	2569-2578	VBG	denotes	including
T3602	2579-2592	JJ	denotes	mitochondrial
T3603	2593-2601	NN	denotes	function
T3604	2602-2605	CC	denotes	and
T3605	2606-2616	NN	denotes	biogenesis
T3606	2617-2618	-LRB-	denotes	[
T3607	2620-2621	CD	denotes	2
T3608	2618-2619	CD	denotes	1
T3609	2619-2620	,	denotes	,
T3610	2621-2622	-RRB-	denotes	]
T3611	2622-2623	.	denotes	.
T3612	2623-2771	sentence	denotes	PGC-1α was discovered in a yeast two-hybrid screen for brown adipose-specific factors that interact with the adipogenic nuclear receptor PPARγ [2].
T3613	2624-2627	NN	denotes	PGC
T3614	2628-2630	NN	denotes	1α
T3615	2627-2628	HYPH	denotes	-
T3616	2635-2645	VBN	denotes	discovered
T3617	2631-2634	VBD	denotes	was
T3618	2646-2648	IN	denotes	in
T3619	2649-2650	DT	denotes	a
T3620	2668-2674	NN	denotes	screen
T3621	2651-2656	NN	denotes	yeast
T3622	2657-2660	CD	denotes	two
T3623	2661-2667	NN	denotes	hybrid
T3624	2660-2661	HYPH	denotes	-
T3625	2675-2678	IN	denotes	for
T3626	2679-2684	JJ	denotes	brown
T3627	2685-2692	NN	denotes	adipose
T3628	2693-2701	JJ	denotes	specific
T3629	2692-2693	HYPH	denotes	-
T3630	2702-2709	NNS	denotes	factors
T3631	2710-2714	WDT	denotes	that
T3632	2715-2723	VBP	denotes	interact
T3633	2724-2728	IN	denotes	with
T3634	2729-2732	DT	denotes	the
T3635	2752-2760	NN	denotes	receptor
T3636	2733-2743	JJ	denotes	adipogenic
T3637	2744-2751	JJ	denotes	nuclear
T3638	2761-2766	NN	denotes	PPARγ
T3639	2767-2768	-LRB-	denotes	[
T3640	2768-2769	CD	denotes	2
T3641	2769-2770	-RRB-	denotes	]
T3642	2770-2771	.	denotes	.
T3643	2771-2892	sentence	denotes	Subsequently, two additional PGC-1 family members were identified, PGC-1 related coactivator (PRC) [3] and PGC-1β [4,5].
T3644	2772-2784	RB	denotes	Subsequently
T3645	2827-2837	VBN	denotes	identified
T3646	2784-2786	,	denotes	,
T3647	2786-2789	CD	denotes	two
T3648	2814-2821	NNS	denotes	members
T3649	2790-2800	JJ	denotes	additional
T3650	2801-2804	NN	denotes	PGC
T3651	2804-2805	HYPH	denotes	-
T3652	2805-2806	CD	denotes	1
T3653	2807-2813	NN	denotes	family
T3654	2822-2826	VBD	denotes	were
T3655	2837-2839	,	denotes	,
T3656	2839-2842	NN	denotes	PGC
T3657	2845-2852	VBN	denotes	related
T3658	2842-2843	HYPH	denotes	-
T3659	2843-2844	CD	denotes	1
T3660	2853-2864	NN	denotes	coactivator
T3661	2865-2866	-LRB-	denotes	(
T3662	2866-2869	NN	denotes	PRC
T3663	2869-2870	-RRB-	denotes	)
T3664	2871-2872	-LRB-	denotes	[
T3665	2872-2873	CD	denotes	3
T3666	2873-2874	-RRB-	denotes	]
T3667	2875-2878	CC	denotes	and
T3668	2879-2882	NN	denotes	PGC
T3669	2883-2885	NN	denotes	1β
T3670	2882-2883	HYPH	denotes	-
T3671	2886-2887	-LRB-	denotes	[
T3672	2889-2890	CD	denotes	5
T3673	2887-2888	CD	denotes	4
T3674	2888-2889	,	denotes	,
T3675	2890-2891	-RRB-	denotes	]
T3676	2891-2892	.	denotes	.
T3677	2892-3047	sentence	denotes	PGC-1α serves as a direct transcriptional coactivator of nuclear and nonnuclear receptor transcription factors involved in cellular energy metabolism [6].
T3678	2893-2896	NN	denotes	PGC
T3679	2897-2899	NN	denotes	1α
T3680	2896-2897	HYPH	denotes	-
T3681	2900-2906	VBZ	denotes	serves
T3682	2907-2909	IN	denotes	as
T3683	2910-2911	DT	denotes	a
T3684	2935-2946	NN	denotes	coactivator
T3685	2912-2918	JJ	denotes	direct
T3686	2919-2934	JJ	denotes	transcriptional
T3687	2947-2949	IN	denotes	of
T3688	2950-2957	JJ	denotes	nuclear
T3689	2996-3003	NNS	denotes	factors
T3690	2958-2961	CC	denotes	and
T3691	2962-2972	JJ	denotes	nonnuclear
T3692	2973-2981	NN	denotes	receptor
T3693	2982-2995	NN	denotes	transcription
T3694	3004-3012	VBN	denotes	involved
T3695	3013-3015	IN	denotes	in
T3696	3016-3024	JJ	denotes	cellular
T3697	3032-3042	NN	denotes	metabolism
T3698	3025-3031	NN	denotes	energy
T3699	3043-3044	-LRB-	denotes	[
T3700	3044-3045	CD	denotes	6
T3701	3045-3046	-RRB-	denotes	]
T3702	3046-3047	.	denotes	.
T3703	3047-3276	sentence	denotes	PGC-1α is distinct among most coactivators in that it exhibits a tissue-enriched expression pattern and is highly inducible by physiologic conditions known to increase the demand for mitochondrial ATP or heat production [2,6,7].
T3704	3048-3051	NN	denotes	PGC
T3705	3052-3054	NN	denotes	1α
T3706	3051-3052	HYPH	denotes	-
T3707	3055-3057	VBZ	denotes	is
T3708	3058-3066	JJ	denotes	distinct
T3709	3067-3072	IN	denotes	among
T3710	3073-3077	JJS	denotes	most
T3711	3078-3090	NNS	denotes	coactivators
T3712	3091-3093	IN	denotes	in
T3713	3102-3110	VBZ	denotes	exhibits
T3714	3094-3098	IN	denotes	that
T3715	3099-3101	PRP	denotes	it
T3716	3111-3112	DT	denotes	a
T3717	3140-3147	NN	denotes	pattern
T3718	3113-3119	NN	denotes	tissue
T3719	3120-3128	VBN	denotes	enriched
T3720	3119-3120	HYPH	denotes	-
T3721	3129-3139	NN	denotes	expression
T3722	3148-3151	CC	denotes	and
T3723	3152-3154	VBZ	denotes	is
T3724	3155-3161	RB	denotes	highly
T3725	3162-3171	JJ	denotes	inducible
T3726	3172-3174	IN	denotes	by
T3727	3175-3186	JJ	denotes	physiologic
T3728	3187-3197	NNS	denotes	conditions
T3729	3198-3203	VBN	denotes	known
T3730	3204-3206	TO	denotes	to
T3731	3207-3215	VB	denotes	increase
T3732	3216-3219	DT	denotes	the
T3733	3220-3226	NN	denotes	demand
T3734	3227-3230	IN	denotes	for
T3735	3231-3244	JJ	denotes	mitochondrial
T3736	3245-3248	NN	denotes	ATP
T3737	3249-3251	CC	denotes	or
T3738	3252-3256	NN	denotes	heat
T3739	3257-3267	NN	denotes	production
T3740	3268-3269	-LRB-	denotes	[
T3741	3273-3274	CD	denotes	7
T3742	3269-3270	CD	denotes	2
T3743	3270-3271	,	denotes	,
T3744	3271-3272	CD	denotes	6
T3745	3272-3273	,	denotes	,
T3746	3274-3275	-RRB-	denotes	]
T3747	3275-3276	.	denotes	.
T3748	3276-3427	sentence	denotes	PGC-1α is enriched in brown adipose tissue (BAT), heart, slow-twitch skeletal muscle, and kidney—all tissues with high-capacity mitochondrial systems.
T3749	3277-3280	NN	denotes	PGC
T3750	3281-3283	NN	denotes	1α
T3751	3280-3281	HYPH	denotes	-
T3752	3287-3295	VBN	denotes	enriched
T3753	3284-3286	VBZ	denotes	is
T3754	3296-3298	IN	denotes	in
T3755	3299-3304	JJ	denotes	brown
T3756	3313-3319	NN	denotes	tissue
T3757	3305-3312	NN	denotes	adipose
T3758	3320-3321	-LRB-	denotes	(
T3759	3321-3324	NN	denotes	BAT
T3760	3324-3325	-RRB-	denotes	)
T3761	3325-3327	,	denotes	,
T3762	3327-3332	NN	denotes	heart
T3763	3332-3334	,	denotes	,
T3764	3334-3338	JJ	denotes	slow
T3765	3339-3345	NN	denotes	twitch
T3766	3338-3339	HYPH	denotes	-
T3767	3355-3361	NN	denotes	muscle
T3768	3346-3354	JJ	denotes	skeletal
T3769	3361-3363	,	denotes	,
T3770	3363-3366	CC	denotes	and
T3771	3367-3373	NN	denotes	kidney
T3772	3373-3374	,	denotes	—
T3773	3374-3377	RB	denotes	all
T3774	3378-3385	NNS	denotes	tissues
T3775	3386-3390	IN	denotes	with
T3776	3391-3395	JJ	denotes	high
T3777	3396-3404	NN	denotes	capacity
T3778	3395-3396	HYPH	denotes	-
T3779	3419-3426	NNS	denotes	systems
T3780	3405-3418	JJ	denotes	mitochondrial
T3781	3426-3427	.	denotes	.
T3782	3427-3567	sentence	denotes	The expression of the gene encoding PGC-1α is rapidly induced by cold exposure, short-term exercise, and fasting [2,8,9,10,11,12,13,14,15].
T3783	3428-3431	DT	denotes	The
T3784	3432-3442	NN	denotes	expression
T3785	3482-3489	VBN	denotes	induced
T3786	3443-3445	IN	denotes	of
T3787	3446-3449	DT	denotes	the
T3788	3450-3454	NN	denotes	gene
T3789	3455-3463	VBG	denotes	encoding
T3790	3464-3467	NN	denotes	PGC
T3791	3468-3470	NN	denotes	1α
T3792	3467-3468	HYPH	denotes	-
T3793	3471-3473	VBZ	denotes	is
T3794	3474-3481	RB	denotes	rapidly
T3795	3490-3492	IN	denotes	by
T3796	3493-3497	NN	denotes	cold
T3797	3498-3506	NN	denotes	exposure
T3798	3506-3508	,	denotes	,
T3799	3508-3513	JJ	denotes	short
T3800	3514-3518	NN	denotes	term
T3801	3513-3514	HYPH	denotes	-
T3802	3519-3527	NN	denotes	exercise
T3803	3527-3529	,	denotes	,
T3804	3529-3532	CC	denotes	and
T3805	3533-3540	NN	denotes	fasting
T3806	3541-3542	-LRB-	denotes	[
T3807	3563-3565	CD	denotes	15
T3808	3542-3543	CD	denotes	2
T3809	3543-3544	,	denotes	,
T3810	3544-3545	CD	denotes	8
T3811	3545-3546	,	denotes	,
T3812	3546-3547	CD	denotes	9
T3813	3547-3548	,	denotes	,
T3814	3548-3550	CD	denotes	10
T3815	3550-3551	,	denotes	,
T3816	3551-3553	CD	denotes	11
T3817	3553-3554	,	denotes	,
T3818	3554-3556	CD	denotes	12
T3819	3556-3557	,	denotes	,
T3820	3557-3559	CD	denotes	13
T3821	3559-3560	,	denotes	,
T3822	3560-3562	CD	denotes	14
T3823	3562-3563	,	denotes	,
T3824	3565-3566	-RRB-	denotes	]
T3825	3566-3567	.	denotes	.
T3826	3567-3674	sentence	denotes	These latter observations suggest that PGC-1α is involved in the physiologic control of energy metabolism.
T3827	3568-3573	DT	denotes	These
T3828	3581-3593	NNS	denotes	observations
T3829	3574-3580	JJ	denotes	latter
T3830	3594-3601	VBP	denotes	suggest
T3831	3602-3606	IN	denotes	that
T3832	3617-3625	VBN	denotes	involved
T3833	3607-3610	NN	denotes	PGC
T3834	3611-3613	NN	denotes	1α
T3835	3610-3611	HYPH	denotes	-
T3836	3614-3616	VBZ	denotes	is
T3837	3626-3628	IN	denotes	in
T3838	3629-3632	DT	denotes	the
T3839	3645-3652	NN	denotes	control
T3840	3633-3644	JJ	denotes	physiologic
T3841	3653-3655	IN	denotes	of
T3842	3656-3662	NN	denotes	energy
T3843	3663-3673	NN	denotes	metabolism
T3844	3673-3674	.	denotes	.
T3845	3674-3869	sentence	denotes	Several lines of evidence, based on the results of overexpression studies, indicate that PGC-1α is sufficient to promote mitochondrial biogenesis and regulate mitochondrial respiratory capacity.
T3846	3675-3682	JJ	denotes	Several
T3847	3683-3688	NNS	denotes	lines
T3848	3750-3758	VBP	denotes	indicate
T3849	3689-3691	IN	denotes	of
T3850	3692-3700	NN	denotes	evidence
T3851	3700-3702	,	denotes	,
T3852	3702-3707	VBN	denotes	based
T3853	3708-3710	IN	denotes	on
T3854	3711-3714	DT	denotes	the
T3855	3715-3722	NNS	denotes	results
T3856	3723-3725	IN	denotes	of
T3857	3726-3740	NN	denotes	overexpression
T3858	3741-3748	NNS	denotes	studies
T3859	3748-3750	,	denotes	,
T3860	3759-3763	IN	denotes	that
T3861	3771-3773	VBZ	denotes	is
T3862	3764-3767	NN	denotes	PGC
T3863	3768-3770	NN	denotes	1α
T3864	3767-3768	HYPH	denotes	-
T3865	3774-3784	JJ	denotes	sufficient
T3866	3785-3787	TO	denotes	to
T3867	3788-3795	VB	denotes	promote
T3868	3796-3809	JJ	denotes	mitochondrial
T3869	3810-3820	NN	denotes	biogenesis
T3870	3821-3824	CC	denotes	and
T3871	3825-3833	VBP	denotes	regulate
T3872	3834-3847	JJ	denotes	mitochondrial
T3873	3860-3868	NN	denotes	capacity
T3874	3848-3859	JJ	denotes	respiratory
T3875	3868-3869	.	denotes	.
T3876	3869-4052	sentence	denotes	First, PGC-1α activates the transcription of mitochondrial uncoupling protein-1 (UCP-1) in BAT through interactions with the nuclear hormone receptors PPARγ and thyroid receptor [2].
T3877	3870-3875	RB	denotes	First
T3878	3884-3893	VBZ	denotes	activates
T3879	3875-3877	,	denotes	,
T3880	3877-3880	NN	denotes	PGC
T3881	3881-3883	NN	denotes	1α
T3882	3880-3881	HYPH	denotes	-
T3883	3894-3897	DT	denotes	the
T3884	3898-3911	NN	denotes	transcription
T3885	3912-3914	IN	denotes	of
T3886	3915-3928	JJ	denotes	mitochondrial
T3887	3940-3947	NN	denotes	protein
T3888	3929-3939	NN	denotes	uncoupling
T3889	3947-3948	HYPH	denotes	-
T3890	3948-3949	CD	denotes	1
T3891	3950-3951	-LRB-	denotes	(
T3892	3951-3954	NN	denotes	UCP
T3893	3954-3955	HYPH	denotes	-
T3894	3955-3956	CD	denotes	1
T3895	3956-3957	-RRB-	denotes	)
T3896	3958-3960	IN	denotes	in
T3897	3961-3964	NN	denotes	BAT
T3898	3965-3972	IN	denotes	through
T3899	3973-3985	NNS	denotes	interactions
T3900	3986-3990	IN	denotes	with
T3901	3991-3994	DT	denotes	the
T3902	4011-4020	NNS	denotes	receptors
T3903	3995-4002	JJ	denotes	nuclear
T3904	4003-4010	NN	denotes	hormone
T3905	4021-4026	NN	denotes	PPARγ
T3906	4027-4030	CC	denotes	and
T3907	4031-4038	NN	denotes	thyroid
T3908	4039-4047	NN	denotes	receptor
T3909	4048-4049	-LRB-	denotes	[
T3910	4049-4050	CD	denotes	2
T3911	4050-4051	-RRB-	denotes	]
T3912	4051-4052	.	denotes	.
T3913	4052-4439	sentence	denotes	Second, forced expression studies in adipogenic and myogenic mammalian cell lines demonstrated that PGC-1α activates mitochondrial biogenesis through a group of transcription factor targets including nuclear respiratory factors 1 and 2 (NRF-1 and -2) and mitochondrial transcription factor A (Tfam), key transcriptional regulators of mitochondrial DNA transcription and replication [8].
T3914	4053-4059	RB	denotes	Second
T3915	4135-4147	VBD	denotes	demonstrated
T3916	4059-4061	,	denotes	,
T3917	4061-4067	VBN	denotes	forced
T3918	4079-4086	NNS	denotes	studies
T3919	4068-4078	NN	denotes	expression
T3920	4087-4089	IN	denotes	in
T3921	4090-4100	JJ	denotes	adipogenic
T3922	4129-4134	NNS	denotes	lines
T3923	4101-4104	CC	denotes	and
T3924	4105-4113	JJ	denotes	myogenic
T3925	4114-4123	JJ	denotes	mammalian
T3926	4124-4128	NN	denotes	cell
T3927	4148-4152	IN	denotes	that
T3928	4160-4169	VBZ	denotes	activates
T3929	4153-4156	NN	denotes	PGC
T3930	4157-4159	NN	denotes	1α
T3931	4156-4157	HYPH	denotes	-
T3932	4170-4183	JJ	denotes	mitochondrial
T3933	4184-4194	NN	denotes	biogenesis
T3934	4195-4202	IN	denotes	through
T3935	4203-4204	DT	denotes	a
T3936	4205-4210	NN	denotes	group
T3937	4211-4213	IN	denotes	of
T3938	4214-4227	NN	denotes	transcription
T3939	4235-4242	NNS	denotes	targets
T3940	4228-4234	NN	denotes	factor
T3941	4243-4252	VBG	denotes	including
T3942	4253-4260	JJ	denotes	nuclear
T3943	4273-4280	NNS	denotes	factors
T3944	4261-4272	JJ	denotes	respiratory
T3945	4281-4282	CD	denotes	1
T3946	4283-4286	CC	denotes	and
T3947	4287-4288	CD	denotes	2
T3948	4289-4290	-LRB-	denotes	(
T3949	4290-4293	NN	denotes	NRF
T3950	4294-4295	CD	denotes	1
T3951	4293-4294	HYPH	denotes	-
T3952	4296-4299	CC	denotes	and
T3953	4300-4301	HYPH	denotes	-
T3954	4301-4302	CD	denotes	2
T3955	4302-4303	-RRB-	denotes	)
T3956	4304-4307	CC	denotes	and
T3957	4308-4321	JJ	denotes	mitochondrial
T3958	4343-4344	NN	denotes	A
T3959	4322-4335	NN	denotes	transcription
T3960	4336-4342	NN	denotes	factor
T3961	4345-4346	-LRB-	denotes	(
T3962	4346-4350	NN	denotes	Tfam
T3963	4350-4351	-RRB-	denotes	)
T3964	4351-4353	,	denotes	,
T3965	4353-4356	JJ	denotes	key
T3966	4373-4383	NNS	denotes	regulators
T3967	4357-4372	JJ	denotes	transcriptional
T3968	4384-4386	IN	denotes	of
T3969	4387-4400	JJ	denotes	mitochondrial
T3970	4405-4418	NN	denotes	transcription
T3971	4401-4404	NN	denotes	DNA
T3972	4419-4422	CC	denotes	and
T3973	4423-4434	NN	denotes	replication
T3974	4435-4436	-LRB-	denotes	[
T3975	4436-4437	CD	denotes	8
T3976	4437-4438	-RRB-	denotes	]
T3977	4438-4439	.	denotes	.
T3978	4439-4621	sentence	denotes	Third, studies in primary cardiac myocytes in culture and in the hearts of transgenic mice have demonstrated that overexpression of PGC-1α promotes mitochondrial biogenesis [10,16].
T3979	4440-4445	RB	denotes	Third
T3980	4536-4548	VBN	denotes	demonstrated
T3981	4445-4447	,	denotes	,
T3982	4447-4454	NNS	denotes	studies
T3983	4455-4457	IN	denotes	in
T3984	4458-4465	JJ	denotes	primary
T3985	4474-4482	NNS	denotes	myocytes
T3986	4466-4473	JJ	denotes	cardiac
T3987	4483-4485	IN	denotes	in
T3988	4486-4493	NN	denotes	culture
T3989	4494-4497	CC	denotes	and
T3990	4498-4500	IN	denotes	in
T3991	4501-4504	DT	denotes	the
T3992	4505-4511	NNS	denotes	hearts
T3993	4512-4514	IN	denotes	of
T3994	4515-4525	JJ	denotes	transgenic
T3995	4526-4530	NNS	denotes	mice
T3996	4531-4535	VBP	denotes	have
T3997	4549-4553	IN	denotes	that
T3998	4579-4587	VBZ	denotes	promotes
T3999	4554-4568	NN	denotes	overexpression
T4000	4569-4571	IN	denotes	of
T4001	4572-4575	NN	denotes	PGC
T4002	4576-4578	NN	denotes	1α
T4003	4575-4576	HYPH	denotes	-
T4004	4588-4601	JJ	denotes	mitochondrial
T4005	4602-4612	NN	denotes	biogenesis
T4006	4613-4614	-LRB-	denotes	[
T4007	4617-4619	CD	denotes	16
T4008	4614-4616	CD	denotes	10
T4009	4616-4617	,	denotes	,
T4010	4619-4620	-RRB-	denotes	]
T4011	4620-4621	.	denotes	.
T4012	4621-4826	sentence	denotes	Lastly, forced expression of PGC-1α in skeletal muscle of transgenic mice triggers mitochondrial proliferation and the formation of mitochondrial-rich type I, oxidative (“slow-twitch”) muscle fibers [17].
T4013	4622-4628	RB	denotes	Lastly
T4014	4696-4704	VBZ	denotes	triggers
T4015	4628-4630	,	denotes	,
T4016	4630-4636	VBN	denotes	forced
T4017	4637-4647	NN	denotes	expression
T4018	4648-4650	IN	denotes	of
T4019	4651-4654	NN	denotes	PGC
T4020	4655-4657	NN	denotes	1α
T4021	4654-4655	HYPH	denotes	-
T4022	4658-4660	IN	denotes	in
T4023	4661-4669	JJ	denotes	skeletal
T4024	4670-4676	NN	denotes	muscle
T4025	4677-4679	IN	denotes	of
T4026	4680-4690	JJ	denotes	transgenic
T4027	4691-4695	NNS	denotes	mice
T4028	4705-4718	JJ	denotes	mitochondrial
T4029	4719-4732	NN	denotes	proliferation
T4030	4733-4736	CC	denotes	and
T4031	4737-4740	DT	denotes	the
T4032	4741-4750	NN	denotes	formation
T4033	4751-4753	IN	denotes	of
T4034	4754-4767	JJ	denotes	mitochondrial
T4035	4768-4772	JJ	denotes	rich
T4036	4767-4768	HYPH	denotes	-
T4037	4814-4820	NNS	denotes	fibers
T4038	4773-4777	NN	denotes	type
T4039	4778-4779	CD	denotes	I
T4040	4779-4781	,	denotes	,
T4041	4781-4790	JJ	denotes	oxidative
T4042	4791-4792	-LRB-	denotes	(
T4043	4792-4793	``	denotes	“
T4044	4793-4797	JJ	denotes	slow
T4045	4798-4804	NN	denotes	twitch
T4046	4797-4798	HYPH	denotes	-
T4047	4804-4805	''	denotes	”
T4048	4805-4806	-RRB-	denotes	)
T4049	4807-4813	NN	denotes	muscle
T4050	4821-4822	-LRB-	denotes	[
T4051	4822-4824	CD	denotes	17
T4052	4824-4825	-RRB-	denotes	]
T4053	4825-4826	.	denotes	.
T4054	4826-4924	sentence	denotes	Collectively, these results indicate that PGC-1α is sufficient to drive mitochondrial biogenesis.
T4055	4827-4839	RB	denotes	Collectively
T4056	4855-4863	VBP	denotes	indicate
T4057	4839-4841	,	denotes	,
T4058	4841-4846	DT	denotes	these
T4059	4847-4854	NNS	denotes	results
T4060	4864-4868	IN	denotes	that
T4061	4876-4878	VBZ	denotes	is
T4062	4869-4872	NN	denotes	PGC
T4063	4873-4875	NN	denotes	1α
T4064	4872-4873	HYPH	denotes	-
T4065	4879-4889	JJ	denotes	sufficient
T4066	4890-4892	TO	denotes	to
T4067	4893-4898	VB	denotes	drive
T4068	4899-4912	JJ	denotes	mitochondrial
T4069	4913-4923	NN	denotes	biogenesis
T4070	4923-4924	.	denotes	.
T4071	4924-5021	sentence	denotes	Recent evidence also implicates PGC-1α in the homeostatic control of systemic energy metabolism.
T4072	4925-4931	JJ	denotes	Recent
T4073	4932-4940	NN	denotes	evidence
T4074	4946-4956	VBZ	denotes	implicates
T4075	4941-4945	RB	denotes	also
T4076	4957-4960	NN	denotes	PGC
T4077	4961-4963	NN	denotes	1α
T4078	4960-4961	HYPH	denotes	-
T4079	4964-4966	IN	denotes	in
T4080	4967-4970	DT	denotes	the
T4081	4983-4990	NN	denotes	control
T4082	4971-4982	JJ	denotes	homeostatic
T4083	4991-4993	IN	denotes	of
T4084	4994-5002	JJ	denotes	systemic
T4085	5010-5020	NN	denotes	metabolism
T4086	5003-5009	NN	denotes	energy
T4087	5020-5021	.	denotes	.
T4088	5021-5110	sentence	denotes	PGC-1α has been shown to regulate several key hepatic gluconeogenic genes [18,19,20,21].
T4089	5022-5025	NN	denotes	PGC
T4090	5026-5028	NN	denotes	1α
T4091	5025-5026	HYPH	denotes	-
T4092	5038-5043	VBN	denotes	shown
T4093	5029-5032	VBZ	denotes	has
T4094	5033-5037	VBN	denotes	been
T4095	5044-5046	TO	denotes	to
T4096	5047-5055	VB	denotes	regulate
T4097	5056-5063	JJ	denotes	several
T4098	5090-5095	NNS	denotes	genes
T4099	5064-5067	JJ	denotes	key
T4100	5068-5075	JJ	denotes	hepatic
T4101	5076-5089	JJ	denotes	gluconeogenic
T4102	5096-5097	-LRB-	denotes	[
T4103	5106-5108	CD	denotes	21
T4104	5097-5099	CD	denotes	18
T4105	5099-5100	,	denotes	,
T4106	5100-5102	CD	denotes	19
T4107	5102-5103	,	denotes	,
T4108	5103-5105	CD	denotes	20
T4109	5105-5106	,	denotes	,
T4110	5108-5109	-RRB-	denotes	]
T4111	5109-5110	.	denotes	.
T4112	5110-5293	sentence	denotes	Recent studies have also shown altered expression of PGC-1α and downstream mitochondrial target pathways in skeletal muscle of humans with insulin resistance and diabetes [22,23,24].
T4113	5111-5117	JJ	denotes	Recent
T4114	5118-5125	NNS	denotes	studies
T4115	5136-5141	VBN	denotes	shown
T4116	5126-5130	VBP	denotes	have
T4117	5131-5135	RB	denotes	also
T4118	5142-5149	VBN	denotes	altered
T4119	5150-5160	NN	denotes	expression
T4120	5161-5163	IN	denotes	of
T4121	5164-5167	NN	denotes	PGC
T4122	5168-5170	NN	denotes	1α
T4123	5167-5168	HYPH	denotes	-
T4124	5207-5215	NNS	denotes	pathways
T4125	5171-5174	CC	denotes	and
T4126	5175-5185	JJ	denotes	downstream
T4127	5186-5199	JJ	denotes	mitochondrial
T4128	5200-5206	NN	denotes	target
T4129	5216-5218	IN	denotes	in
T4130	5219-5227	JJ	denotes	skeletal
T4131	5228-5234	NN	denotes	muscle
T4132	5235-5237	IN	denotes	of
T4133	5238-5244	NNS	denotes	humans
T4134	5245-5249	IN	denotes	with
T4135	5250-5257	NN	denotes	insulin
T4136	5258-5268	NN	denotes	resistance
T4137	5269-5272	CC	denotes	and
T4138	5273-5281	NN	denotes	diabetes
T4139	5282-5283	-LRB-	denotes	[
T4140	5289-5291	CD	denotes	24
T4141	5283-5285	CD	denotes	22
T4142	5285-5286	,	denotes	,
T4143	5286-5288	CD	denotes	23
T4144	5288-5289	,	denotes	,
T4145	5291-5292	-RRB-	denotes	]
T4146	5292-5293	.	denotes	.
T4147	5293-5462	sentence	denotes	In addition, single nucleotide polymorphisms within the human PGC-1α gene have been shown to be associated with obesity, hypertension, and diabetes [25,26,27,28,29,30].
T4148	5294-5296	IN	denotes	In
T4149	5378-5383	VBN	denotes	shown
T4150	5297-5305	NN	denotes	addition
T4151	5305-5307	,	denotes	,
T4152	5307-5313	JJ	denotes	single
T4153	5314-5324	NN	denotes	nucleotide
T4154	5325-5338	NNS	denotes	polymorphisms
T4155	5339-5345	IN	denotes	within
T4156	5346-5349	DT	denotes	the
T4157	5363-5367	NN	denotes	gene
T4158	5350-5355	JJ	denotes	human
T4159	5356-5359	NN	denotes	PGC
T4160	5360-5362	NN	denotes	1α
T4161	5359-5360	HYPH	denotes	-
T4162	5368-5372	VBP	denotes	have
T4163	5373-5377	VBN	denotes	been
T4164	5384-5386	TO	denotes	to
T4165	5390-5400	VBN	denotes	associated
T4166	5387-5389	VB	denotes	be
T4167	5401-5405	IN	denotes	with
T4168	5406-5413	NN	denotes	obesity
T4169	5413-5415	,	denotes	,
T4170	5415-5427	NN	denotes	hypertension
T4171	5427-5429	,	denotes	,
T4172	5429-5432	CC	denotes	and
T4173	5433-5441	NN	denotes	diabetes
T4174	5442-5443	-LRB-	denotes	[
T4175	5458-5460	CD	denotes	30
T4176	5443-5445	CD	denotes	25
T4177	5445-5446	,	denotes	,
T4178	5446-5448	CD	denotes	26
T4179	5448-5449	,	denotes	,
T4180	5449-5451	CD	denotes	27
T4181	5451-5452	,	denotes	,
T4182	5452-5454	CD	denotes	28
T4183	5454-5455	,	denotes	,
T4184	5455-5457	CD	denotes	29
T4185	5457-5458	,	denotes	,
T4186	5460-5461	-RRB-	denotes	]
T4187	5461-5462	.	denotes	.
T4188	5462-5603	sentence	denotes	The gain-of-function studies described to date provide compelling evidence that PGC-1α is capable of regulating postnatal energy metabolism.
T4189	5463-5466	DT	denotes	The
T4190	5484-5491	NNS	denotes	studies
T4191	5467-5471	NN	denotes	gain
T4192	5471-5472	HYPH	denotes	-
T4193	5472-5474	IN	denotes	of
T4194	5474-5475	HYPH	denotes	-
T4195	5475-5483	NN	denotes	function
T4196	5510-5517	VBP	denotes	provide
T4197	5492-5501	VBN	denotes	described
T4198	5502-5504	IN	denotes	to
T4199	5505-5509	NN	denotes	date
T4200	5518-5528	JJ	denotes	compelling
T4201	5529-5537	NN	denotes	evidence
T4202	5538-5542	IN	denotes	that
T4203	5550-5552	VBZ	denotes	is
T4204	5543-5546	NN	denotes	PGC
T4205	5547-5549	NN	denotes	1α
T4206	5546-5547	HYPH	denotes	-
T4207	5553-5560	JJ	denotes	capable
T4208	5561-5563	IN	denotes	of
T4209	5564-5574	VBG	denotes	regulating
T4210	5575-5584	JJ	denotes	postnatal
T4211	5592-5602	NN	denotes	metabolism
T4212	5585-5591	NN	denotes	energy
T4213	5602-5603	.	denotes	.
T4214	5603-5777	sentence	denotes	However, the necessity of PGC-1α for energy metabolic homeostasis, mitochondrial biogenesis, development, and growth can only be addressed using loss-of-function strategies.
T4215	5604-5611	RB	denotes	However
T4216	5733-5742	VBN	denotes	addressed
T4217	5611-5613	,	denotes	,
T4218	5613-5616	DT	denotes	the
T4219	5617-5626	NN	denotes	necessity
T4220	5627-5629	IN	denotes	of
T4221	5630-5633	NN	denotes	PGC
T4222	5634-5636	NN	denotes	1α
T4223	5633-5634	HYPH	denotes	-
T4224	5637-5640	IN	denotes	for
T4225	5641-5647	NN	denotes	energy
T4226	5658-5669	NN	denotes	homeostasis
T4227	5648-5657	JJ	denotes	metabolic
T4228	5669-5671	,	denotes	,
T4229	5671-5684	JJ	denotes	mitochondrial
T4230	5685-5695	NN	denotes	biogenesis
T4231	5695-5697	,	denotes	,
T4232	5697-5708	NN	denotes	development
T4233	5708-5710	,	denotes	,
T4234	5710-5713	CC	denotes	and
T4235	5714-5720	NN	denotes	growth
T4236	5721-5724	MD	denotes	can
T4237	5725-5729	RB	denotes	only
T4238	5730-5732	VB	denotes	be
T4239	5743-5748	VBG	denotes	using
T4240	5749-5753	NN	denotes	loss
T4241	5766-5776	NNS	denotes	strategies
T4242	5753-5754	HYPH	denotes	-
T4243	5754-5756	IN	denotes	of
T4244	5756-5757	HYPH	denotes	-
T4245	5757-5765	NN	denotes	function
T4246	5776-5777	.	denotes	.
T4247	5777-5876	sentence	denotes	To this end, we have established and characterized mice with targeted deletion of the PGC-1α gene.
T4248	5778-5780	IN	denotes	To
T4249	5799-5810	VBN	denotes	established
T4250	5781-5785	DT	denotes	this
T4251	5786-5789	NN	denotes	end
T4252	5789-5791	,	denotes	,
T4253	5791-5793	PRP	denotes	we
T4254	5794-5798	VBP	denotes	have
T4255	5811-5814	CC	denotes	and
T4256	5815-5828	VBN	denotes	characterized
T4257	5829-5833	NNS	denotes	mice
T4258	5834-5838	IN	denotes	with
T4259	5839-5847	VBN	denotes	targeted
T4260	5848-5856	NN	denotes	deletion
T4261	5857-5859	IN	denotes	of
T4262	5860-5863	DT	denotes	the
T4263	5871-5875	NN	denotes	gene
T4264	5864-5867	NN	denotes	PGC
T4265	5868-5870	NN	denotes	1α
T4266	5867-5868	HYPH	denotes	-
T4267	5875-5876	.	denotes	.
T4268	5876-6016	sentence	denotes	Our studies of PGC-1α−/− mice demonstrate that PGC-1α is not absolutely required for prenatal viability including mitochondrial biogenesis.
T4269	5877-5880	PRP$	denotes	Our
T4270	5881-5888	NNS	denotes	studies
T4271	5907-5918	VBP	denotes	demonstrate
T4272	5889-5891	IN	denotes	of
T4273	5892-5895	NN	denotes	PGC
T4274	5896-5898	NN	denotes	1α
T4275	5895-5896	HYPH	denotes	-
T4276	5902-5906	NNS	denotes	mice
T4277	5898-5899	SYM	denotes	−
T4278	5899-5900	HYPH	denotes	/
T4279	5900-5901	SYM	denotes	−
T4280	5919-5923	IN	denotes	that
T4281	5949-5957	VBN	denotes	required
T4282	5924-5927	NN	denotes	PGC
T4283	5928-5930	NN	denotes	1α
T4284	5927-5928	HYPH	denotes	-
T4285	5931-5933	VBZ	denotes	is
T4286	5934-5937	RB	denotes	not
T4287	5938-5948	RB	denotes	absolutely
T4288	5958-5961	IN	denotes	for
T4289	5962-5970	JJ	denotes	prenatal
T4290	5971-5980	NN	denotes	viability
T4291	5981-5990	VBG	denotes	including
T4292	5991-6004	JJ	denotes	mitochondrial
T4293	6005-6015	NN	denotes	biogenesis
T4294	6015-6016	.	denotes	.
T4295	6016-6226	sentence	denotes	However, our findings indicate that the coactivator PGC-1α serves a critical role in the normal metabolic function of multiple organs and for appropriate adaptation to physiologic stress during postnatal life.
T4296	6017-6024	RB	denotes	However
T4297	6039-6047	VBP	denotes	indicate
T4298	6024-6026	,	denotes	,
T4299	6026-6029	PRP$	denotes	our
T4300	6030-6038	NNS	denotes	findings
T4301	6048-6052	IN	denotes	that
T4302	6076-6082	VBZ	denotes	serves
T4303	6053-6056	DT	denotes	the
T4304	6057-6068	NN	denotes	coactivator
T4305	6069-6072	NN	denotes	PGC
T4306	6073-6075	NN	denotes	1α
T4307	6072-6073	HYPH	denotes	-
T4308	6083-6084	DT	denotes	a
T4309	6094-6098	NN	denotes	role
T4310	6085-6093	JJ	denotes	critical
T4311	6099-6101	IN	denotes	in
T4312	6102-6105	DT	denotes	the
T4313	6123-6131	NN	denotes	function
T4314	6106-6112	JJ	denotes	normal
T4315	6113-6122	JJ	denotes	metabolic
T4316	6132-6134	IN	denotes	of
T4317	6135-6143	JJ	denotes	multiple
T4318	6144-6150	NNS	denotes	organs
T4319	6151-6154	CC	denotes	and
T4320	6155-6158	IN	denotes	for
T4321	6159-6170	JJ	denotes	appropriate
T4322	6171-6181	NN	denotes	adaptation
T4323	6182-6184	IN	denotes	to
T4324	6185-6196	JJ	denotes	physiologic
T4325	6197-6203	NN	denotes	stress
T4326	6204-6210	IN	denotes	during
T4327	6211-6220	JJ	denotes	postnatal
T4328	6221-6225	NN	denotes	life
T4329	6225-6226	.	denotes	.
T5681	6237-6247	NN	denotes	Disruption
T5682	6248-6250	IN	denotes	of
T5683	6251-6254	DT	denotes	the
T5684	6262-6266	NN	denotes	Gene
T5685	6255-6258	NN	denotes	PGC
T5686	6259-6261	NN	denotes	1α
T5687	6258-6259	HYPH	denotes	-
T5688	6267-6269	IN	denotes	in
T5689	6270-6274	NNS	denotes	Mice
T5690	6274-6378	sentence	denotes	A neomycin-based gene targeting vector was generated to delete exons 4 and 5 of the murine PGC-1α gene.
T5691	6275-6276	DT	denotes	A
T5692	6307-6313	NN	denotes	vector
T5693	6277-6285	NN	denotes	neomycin
T5694	6286-6291	VBN	denotes	based
T5695	6285-6286	HYPH	denotes	-
T5696	6292-6296	NN	denotes	gene
T5697	6297-6306	NN	denotes	targeting
T5698	6318-6327	VBN	denotes	generated
T5699	6314-6317	VBD	denotes	was
T5700	6328-6330	TO	denotes	to
T5701	6331-6337	VB	denotes	delete
T5702	6338-6343	NNS	denotes	exons
T5703	6344-6345	CD	denotes	4
T5704	6346-6349	CC	denotes	and
T5705	6350-6351	CD	denotes	5
T5706	6352-6354	IN	denotes	of
T5707	6355-6358	DT	denotes	the
T5708	6373-6377	NN	denotes	gene
T5709	6359-6365	JJ	denotes	murine
T5710	6366-6369	NN	denotes	PGC
T5711	6370-6372	NN	denotes	1α
T5712	6369-6370	HYPH	denotes	-
T5713	6377-6378	.	denotes	.
T5714	6378-6502	sentence	denotes	The targeting event resulted in a 3′ homologous recombination with insertion of the remainder of the construct (Figure 1A).
T5715	6379-6382	DT	denotes	The
T5716	6393-6398	NN	denotes	event
T5717	6383-6392	NN	denotes	targeting
T5718	6399-6407	VBD	denotes	resulted
T5719	6408-6410	IN	denotes	in
T5720	6411-6412	DT	denotes	a
T5721	6427-6440	NN	denotes	recombination
T5722	6413-6414	CD	denotes	3
T5723	6414-6415	SYM	denotes	′
T5724	6416-6426	JJ	denotes	homologous
T5725	6441-6445	IN	denotes	with
T5726	6446-6455	NN	denotes	insertion
T5727	6456-6458	IN	denotes	of
T5728	6459-6462	DT	denotes	the
T5729	6463-6472	NN	denotes	remainder
T5730	6473-6475	IN	denotes	of
T5731	6476-6479	DT	denotes	the
T5732	6480-6489	NN	denotes	construct
T5733	6490-6491	-LRB-	denotes	(
T5734	6498-6500	NN	denotes	1A
T5735	6491-6497	NN	denotes	Figure
T5736	6500-6501	-RRB-	denotes	)
T5737	6501-6502	.	denotes	.
T5738	6502-6591	sentence	denotes	The insertion/recombination event was confirmed by Southern blotting and DNA sequencing.
T5739	6503-6506	DT	denotes	The
T5740	6531-6536	NN	denotes	event
T5741	6507-6516	NN	denotes	insertion
T5742	6517-6530	NN	denotes	recombination
T5743	6516-6517	HYPH	denotes	/
T5744	6541-6550	VBN	denotes	confirmed
T5745	6537-6540	VBD	denotes	was
T5746	6551-6553	IN	denotes	by
T5747	6554-6562	NNP	denotes	Southern
T5748	6563-6571	NN	denotes	blotting
T5749	6572-6575	CC	denotes	and
T5750	6576-6579	NN	denotes	DNA
T5751	6580-6590	NN	denotes	sequencing
T5752	6590-6591	.	denotes	.
T5753	6591-6752	sentence	denotes	The insertion caused an exon 3 duplication between exons 5 and 6 that creates a coding region frameshift resulting in a premature termination at amino acid 255.
T5754	6592-6595	DT	denotes	The
T5755	6596-6605	NN	denotes	insertion
T5756	6606-6612	VBD	denotes	caused
T5757	6613-6615	DT	denotes	an
T5758	6623-6634	NN	denotes	duplication
T5759	6616-6620	NN	denotes	exon
T5760	6621-6622	CD	denotes	3
T5761	6635-6642	IN	denotes	between
T5762	6643-6648	NNS	denotes	exons
T5763	6649-6650	CD	denotes	5
T5764	6651-6654	CC	denotes	and
T5765	6655-6656	CD	denotes	6
T5766	6657-6661	WDT	denotes	that
T5767	6662-6669	VBZ	denotes	creates
T5768	6670-6671	DT	denotes	a
T5769	6686-6696	NN	denotes	frameshift
T5770	6672-6678	VBG	denotes	coding
T5771	6679-6685	NN	denotes	region
T5772	6697-6706	VBG	denotes	resulting
T5773	6707-6709	IN	denotes	in
T5774	6710-6711	DT	denotes	a
T5775	6722-6733	NN	denotes	termination
T5776	6712-6721	JJ	denotes	premature
T5777	6734-6736	IN	denotes	at
T5778	6737-6742	NN	denotes	amino
T5779	6743-6747	NN	denotes	acid
T5780	6748-6751	CD	denotes	255
T5781	6751-6752	.	denotes	.
T5782	6752-6873	sentence	denotes	Germline transmission of the mutant allele was confirmed using Southern blotting (Figure 1B) and PCR (unpublished data).
T5783	6753-6761	NN	denotes	Germline
T5784	6762-6774	NN	denotes	transmission
T5785	6800-6809	VBN	denotes	confirmed
T5786	6775-6777	IN	denotes	of
T5787	6778-6781	DT	denotes	the
T5788	6789-6795	NN	denotes	allele
T5789	6782-6788	NN	denotes	mutant
T5790	6796-6799	VBD	denotes	was
T5791	6810-6815	VBG	denotes	using
T5792	6816-6824	NNP	denotes	Southern
T5793	6825-6833	NN	denotes	blotting
T5794	6834-6835	-LRB-	denotes	(
T5795	6842-6844	NN	denotes	1B
T5796	6835-6841	NN	denotes	Figure
T5797	6844-6845	-RRB-	denotes	)
T5798	6846-6849	CC	denotes	and
T5799	6850-6853	NN	denotes	PCR
T5800	6854-6855	-LRB-	denotes	(
T5801	6867-6871	NNS	denotes	data
T5802	6855-6866	JJ	denotes	unpublished
T5803	6871-6872	-RRB-	denotes	)
T5804	6872-6873	.	denotes	.
T5805	6873-7062	sentence	denotes	The PGC-1α gene disruption resulted in an unstable transcript that could not be detected by RNA blot analysis in heart and other tissues in PGC-1α−/− mice (Figure 1C and unpublished data).
T5806	6874-6877	DT	denotes	The
T5807	6890-6900	NN	denotes	disruption
T5808	6878-6881	NN	denotes	PGC
T5809	6882-6884	NN	denotes	1α
T5810	6881-6882	HYPH	denotes	-
T5811	6885-6889	NN	denotes	gene
T5812	6901-6909	VBD	denotes	resulted
T5813	6910-6912	IN	denotes	in
T5814	6913-6915	DT	denotes	an
T5815	6925-6935	NN	denotes	transcript
T5816	6916-6924	JJ	denotes	unstable
T5817	6936-6940	WDT	denotes	that
T5818	6954-6962	VBN	denotes	detected
T5819	6941-6946	MD	denotes	could
T5820	6947-6950	RB	denotes	not
T5821	6951-6953	VB	denotes	be
T5822	6963-6965	IN	denotes	by
T5823	6966-6969	NN	denotes	RNA
T5824	6975-6983	NN	denotes	analysis
T5825	6970-6974	NN	denotes	blot
T5826	6984-6986	IN	denotes	in
T5827	6987-6992	NN	denotes	heart
T5828	6993-6996	CC	denotes	and
T5829	6997-7002	JJ	denotes	other
T5830	7003-7010	NNS	denotes	tissues
T5831	7011-7013	IN	denotes	in
T5832	7014-7017	NN	denotes	PGC
T5833	7018-7020	NN	denotes	1α
T5834	7017-7018	HYPH	denotes	-
T5835	7024-7028	NNS	denotes	mice
T5836	7020-7021	SYM	denotes	−
T5837	7021-7022	HYPH	denotes	/
T5838	7022-7023	SYM	denotes	−
T5839	7029-7030	-LRB-	denotes	(
T5840	7037-7039	NN	denotes	1C
T5841	7030-7036	NN	denotes	Figure
T5842	7040-7043	CC	denotes	and
T5843	7044-7055	JJ	denotes	unpublished
T5844	7056-7060	NNS	denotes	data
T5845	7060-7061	-RRB-	denotes	)
T5846	7061-7062	.	denotes	.
T5847	7062-7151	sentence	denotes	Quantitative RT-PCR was utilized to further evaluate the efficacy of the gene targeting.
T5848	7063-7075	JJ	denotes	Quantitative
T5849	7079-7082	NN	denotes	PCR
T5850	7076-7078	NN	denotes	RT
T5851	7078-7079	HYPH	denotes	-
T5852	7087-7095	VBN	denotes	utilized
T5853	7083-7086	VBD	denotes	was
T5854	7096-7098	TO	denotes	to
T5855	7107-7115	VB	denotes	evaluate
T5856	7099-7106	RB	denotes	further
T5857	7116-7119	DT	denotes	the
T5858	7120-7128	NN	denotes	efficacy
T5859	7129-7131	IN	denotes	of
T5860	7132-7135	DT	denotes	the
T5861	7141-7150	NN	denotes	targeting
T5862	7136-7140	NN	denotes	gene
T5863	7150-7151	.	denotes	.
T5864	7151-7397	sentence	denotes	For these studies, PCR primers were designed to amplify a region of the PGC-1α gene transcript containing the exon 5–6 border (predicted to be absent in PGC-1α−/− mice) or the exon 5–3 border (predicted to be present only in the PGC-1α−/− mice).
T5865	7152-7155	IN	denotes	For
T5866	7188-7196	VBN	denotes	designed
T5867	7156-7161	DT	denotes	these
T5868	7162-7169	NNS	denotes	studies
T5869	7169-7171	,	denotes	,
T5870	7171-7174	NN	denotes	PCR
T5871	7175-7182	NNS	denotes	primers
T5872	7183-7187	VBD	denotes	were
T5873	7197-7199	TO	denotes	to
T5874	7200-7207	VB	denotes	amplify
T5875	7208-7209	DT	denotes	a
T5876	7210-7216	NN	denotes	region
T5877	7217-7219	IN	denotes	of
T5878	7220-7223	DT	denotes	the
T5879	7236-7246	NN	denotes	transcript
T5880	7224-7227	NN	denotes	PGC
T5881	7228-7230	NN	denotes	1α
T5882	7227-7228	HYPH	denotes	-
T5883	7231-7235	NN	denotes	gene
T5884	7247-7257	VBG	denotes	containing
T5885	7258-7261	DT	denotes	the
T5886	7271-7277	NN	denotes	border
T5887	7262-7266	NN	denotes	exon
T5888	7267-7268	CD	denotes	5
T5889	7268-7269	SYM	denotes	–
T5890	7269-7270	CD	denotes	6
T5891	7278-7279	-LRB-	denotes	(
T5892	7279-7288	VBN	denotes	predicted
T5893	7289-7291	TO	denotes	to
T5894	7292-7294	VB	denotes	be
T5895	7295-7301	JJ	denotes	absent
T5896	7302-7304	IN	denotes	in
T5897	7305-7308	NN	denotes	PGC
T5898	7309-7311	NN	denotes	1α
T5899	7308-7309	HYPH	denotes	-
T5900	7315-7319	NNS	denotes	mice
T5901	7311-7312	SYM	denotes	−
T5902	7312-7313	HYPH	denotes	/
T5903	7313-7314	SYM	denotes	−
T5904	7319-7320	-RRB-	denotes	)
T5905	7321-7323	CC	denotes	or
T5906	7324-7327	DT	denotes	the
T5907	7337-7343	NN	denotes	border
T5908	7328-7332	NN	denotes	exon
T5909	7333-7334	CD	denotes	5
T5910	7334-7335	SYM	denotes	–
T5911	7335-7336	CD	denotes	3
T5912	7344-7345	-LRB-	denotes	(
T5913	7345-7354	VBN	denotes	predicted
T5914	7355-7357	TO	denotes	to
T5915	7358-7360	VB	denotes	be
T5916	7361-7368	JJ	denotes	present
T5917	7369-7373	RB	denotes	only
T5918	7374-7376	IN	denotes	in
T5919	7377-7380	DT	denotes	the
T5920	7391-7395	NNS	denotes	mice
T5921	7381-7384	NN	denotes	PGC
T5922	7385-7387	NN	denotes	1α
T5923	7384-7385	HYPH	denotes	-
T5924	7387-7388	SYM	denotes	−
T5925	7388-7389	HYPH	denotes	/
T5926	7389-7390	SYM	denotes	−
T5927	7395-7396	-RRB-	denotes	)
T5928	7396-7397	.	denotes	.
T5929	7397-7503	sentence	denotes	The exon 5–6 amplicon was detected in heart and BAT of wild-type (WT) but not PGC-1α−/− mice (Figure 1D).
T5930	7398-7401	DT	denotes	The
T5931	7411-7419	NN	denotes	amplicon
T5932	7402-7406	NN	denotes	exon
T5933	7407-7408	CD	denotes	5
T5934	7408-7409	SYM	denotes	–
T5935	7409-7410	CD	denotes	6
T5936	7424-7432	VBN	denotes	detected
T5937	7420-7423	VBD	denotes	was
T5938	7433-7435	IN	denotes	in
T5939	7436-7441	NN	denotes	heart
T5940	7442-7445	CC	denotes	and
T5941	7446-7449	NN	denotes	BAT
T5942	7450-7452	IN	denotes	of
T5943	7453-7457	JJ	denotes	wild
T5944	7458-7462	NN	denotes	type
T5945	7457-7458	HYPH	denotes	-
T5946	7486-7490	NNS	denotes	mice
T5947	7463-7464	-LRB-	denotes	(
T5948	7464-7466	NN	denotes	WT
T5949	7466-7467	-RRB-	denotes	)
T5950	7468-7471	CC	denotes	but
T5951	7472-7475	RB	denotes	not
T5952	7476-7479	NN	denotes	PGC
T5953	7480-7482	NN	denotes	1α
T5954	7479-7480	HYPH	denotes	-
T5955	7482-7483	SYM	denotes	−
T5956	7483-7484	HYPH	denotes	/
T5957	7484-7485	SYM	denotes	−
T5958	7491-7492	-LRB-	denotes	(
T5959	7499-7501	NN	denotes	1D
T5960	7492-7498	NN	denotes	Figure
T5961	7501-7502	-RRB-	denotes	)
T5962	7502-7503	.	denotes	.
T5963	7503-7584	sentence	denotes	Conversely, the exon 5–3 product was present only in PGC-1α−/− mice (Figure 1D).
T5964	7504-7514	RB	denotes	Conversely
T5965	7537-7540	VBD	denotes	was
T5966	7514-7516	,	denotes	,
T5967	7516-7519	DT	denotes	the
T5968	7529-7536	NN	denotes	product
T5969	7520-7524	NN	denotes	exon
T5970	7525-7526	CD	denotes	5
T5971	7526-7527	SYM	denotes	–
T5972	7527-7528	CD	denotes	3
T5973	7541-7548	JJ	denotes	present
T5974	7549-7553	RB	denotes	only
T5975	7554-7556	IN	denotes	in
T5976	7557-7560	NN	denotes	PGC
T5977	7561-7563	NN	denotes	1α
T5978	7560-7561	HYPH	denotes	-
T5979	7567-7571	NNS	denotes	mice
T5980	7563-7564	SYM	denotes	−
T5981	7564-7565	HYPH	denotes	/
T5982	7565-7566	SYM	denotes	−
T5983	7572-7573	-LRB-	denotes	(
T5984	7580-7582	NN	denotes	1D
T5985	7573-7579	NN	denotes	Figure
T5986	7582-7583	-RRB-	denotes	)
T5987	7583-7584	.	denotes	.
T5988	7584-7798	sentence	denotes	An exon 10–11 border amplicon (predicted to be present in both genotypes) was detected in WT and PGC-1α−/− mice, but was greatly diminished in the PGC-1α−/− mice, indicating that the mutant transcript is unstable.
T5989	7585-7587	DT	denotes	An
T5990	7606-7614	NN	denotes	amplicon
T5991	7588-7592	NN	denotes	exon
T5992	7593-7595	CD	denotes	10
T5993	7595-7596	SYM	denotes	–
T5994	7596-7598	CD	denotes	11
T5995	7599-7605	NN	denotes	border
T5996	7663-7671	VBN	denotes	detected
T5997	7615-7616	-LRB-	denotes	(
T5998	7616-7625	VBN	denotes	predicted
T5999	7626-7628	TO	denotes	to
T6000	7629-7631	VB	denotes	be
T6001	7632-7639	JJ	denotes	present
T6002	7640-7642	IN	denotes	in
T6003	7643-7647	DT	denotes	both
T6004	7648-7657	NNS	denotes	genotypes
T6005	7657-7658	-RRB-	denotes	)
T6006	7659-7662	VBD	denotes	was
T6007	7672-7674	IN	denotes	in
T6008	7675-7677	NN	denotes	WT
T6009	7692-7696	NNS	denotes	mice
T6010	7678-7681	CC	denotes	and
T6011	7682-7685	NN	denotes	PGC
T6012	7686-7688	NN	denotes	1α
T6013	7685-7686	HYPH	denotes	-
T6014	7688-7689	SYM	denotes	−
T6015	7689-7690	HYPH	denotes	/
T6016	7690-7691	SYM	denotes	−
T6017	7696-7698	,	denotes	,
T6018	7698-7701	CC	denotes	but
T6019	7702-7705	VBD	denotes	was
T6020	7714-7724	VBN	denotes	diminished
T6021	7706-7713	RB	denotes	greatly
T6022	7725-7727	IN	denotes	in
T6023	7728-7731	DT	denotes	the
T6024	7742-7746	NNS	denotes	mice
T6025	7732-7735	NN	denotes	PGC
T6026	7736-7738	NN	denotes	1α
T6027	7735-7736	HYPH	denotes	-
T6028	7738-7739	SYM	denotes	−
T6029	7739-7740	HYPH	denotes	/
T6030	7740-7741	SYM	denotes	−
T6031	7746-7748	,	denotes	,
T6032	7748-7758	VBG	denotes	indicating
T6033	7759-7763	IN	denotes	that
T6034	7786-7788	VBZ	denotes	is
T6035	7764-7767	DT	denotes	the
T6036	7775-7785	NN	denotes	transcript
T6037	7768-7774	NN	denotes	mutant
T6038	7789-7797	JJ	denotes	unstable
T6039	7797-7798	.	denotes	.
T6040	7798-8065	sentence	denotes	PGC-1α protein was not detected in whole cell (Figure 1E) or nuclear protein extracts (unpublished data) isolated from BAT of PGC-1α−/− mice under basal conditions or in response to cold exposure, a condition known to markedly induce the expression of PGC-1α in BAT.
T6041	7799-7802	NN	denotes	PGC
T6042	7803-7805	NN	denotes	1α
T6043	7802-7803	HYPH	denotes	-
T6044	7806-7813	NN	denotes	protein
T6045	7822-7830	VBN	denotes	detected
T6046	7814-7817	VBD	denotes	was
T6047	7818-7821	RB	denotes	not
T6048	7831-7833	IN	denotes	in
T6049	7834-7839	JJ	denotes	whole
T6050	7840-7844	NN	denotes	cell
T6051	7876-7884	NNS	denotes	extracts
T6052	7845-7846	-LRB-	denotes	(
T6053	7853-7855	NN	denotes	1E
T6054	7846-7852	NN	denotes	Figure
T6055	7855-7856	-RRB-	denotes	)
T6056	7857-7859	CC	denotes	or
T6057	7860-7867	JJ	denotes	nuclear
T6058	7868-7875	NN	denotes	protein
T6059	7885-7886	-LRB-	denotes	(
T6060	7898-7902	NNS	denotes	data
T6061	7886-7897	JJ	denotes	unpublished
T6062	7902-7903	-RRB-	denotes	)
T6063	7904-7912	VBN	denotes	isolated
T6064	7913-7917	IN	denotes	from
T6065	7918-7921	NN	denotes	BAT
T6066	7922-7924	IN	denotes	of
T6067	7925-7928	NN	denotes	PGC
T6068	7929-7931	NN	denotes	1α
T6069	7928-7929	HYPH	denotes	-
T6070	7935-7939	NNS	denotes	mice
T6071	7931-7932	SYM	denotes	−
T6072	7932-7933	HYPH	denotes	/
T6073	7933-7934	SYM	denotes	−
T6074	7940-7945	IN	denotes	under
T6075	7946-7951	JJ	denotes	basal
T6076	7952-7962	NNS	denotes	conditions
T6077	7963-7965	CC	denotes	or
T6078	7966-7968	IN	denotes	in
T6079	7969-7977	NN	denotes	response
T6080	7978-7980	IN	denotes	to
T6081	7981-7985	NN	denotes	cold
T6082	7986-7994	NN	denotes	exposure
T6083	7994-7996	,	denotes	,
T6084	7996-7997	DT	denotes	a
T6085	7998-8007	NN	denotes	condition
T6086	8008-8013	VBN	denotes	known
T6087	8014-8016	TO	denotes	to
T6088	8026-8032	VB	denotes	induce
T6089	8017-8025	RB	denotes	markedly
T6090	8033-8036	DT	denotes	the
T6091	8037-8047	NN	denotes	expression
T6092	8048-8050	IN	denotes	of
T6093	8051-8054	NN	denotes	PGC
T6094	8055-8057	NN	denotes	1α
T6095	8054-8055	HYPH	denotes	-
T6096	8058-8060	IN	denotes	in
T6097	8061-8064	NN	denotes	BAT
T6098	8064-8065	.	denotes	.
T6099	8065-8164	sentence	denotes	Smaller mutant PGC-1α proteins were also not detected by Western blot analysis (unpublished data).
T6100	8066-8073	JJR	denotes	Smaller
T6101	8088-8096	NN	denotes	proteins
T6102	8074-8080	NN	denotes	mutant
T6103	8081-8084	NN	denotes	PGC
T6104	8085-8087	NN	denotes	1α
T6105	8084-8085	HYPH	denotes	-
T6106	8111-8119	VBN	denotes	detected
T6107	8097-8101	VBD	denotes	were
T6108	8102-8106	RB	denotes	also
T6109	8107-8110	RB	denotes	not
T6110	8120-8122	IN	denotes	by
T6111	8123-8130	NNP	denotes	Western
T6112	8131-8135	NN	denotes	blot
T6113	8136-8144	NN	denotes	analysis
T6114	8145-8146	-LRB-	denotes	(
T6115	8158-8162	NNS	denotes	data
T6116	8146-8157	JJ	denotes	unpublished
T6117	8162-8163	-RRB-	denotes	)
T6118	8163-8164	.	denotes	.
T6119	8164-8329	sentence	denotes	Lastly, expression of the genes encoding the other known PGC-1 family members, PGC-1β and PRC, was not significantly altered in heart of PGC-1α−/− mice (Figure 1C).
T6120	8165-8171	RB	denotes	Lastly
T6121	8282-8289	VBN	denotes	altered
T6122	8171-8173	,	denotes	,
T6123	8173-8183	NN	denotes	expression
T6124	8184-8186	IN	denotes	of
T6125	8187-8190	DT	denotes	the
T6126	8191-8196	NNS	denotes	genes
T6127	8197-8205	VBG	denotes	encoding
T6128	8206-8209	DT	denotes	the
T6129	8235-8242	NNS	denotes	members
T6130	8210-8215	JJ	denotes	other
T6131	8216-8221	JJ	denotes	known
T6132	8222-8225	NN	denotes	PGC
T6133	8225-8226	HYPH	denotes	-
T6134	8226-8227	CD	denotes	1
T6135	8228-8234	NN	denotes	family
T6136	8242-8244	,	denotes	,
T6137	8244-8247	NN	denotes	PGC
T6138	8248-8250	NN	denotes	1β
T6139	8247-8248	HYPH	denotes	-
T6140	8251-8254	CC	denotes	and
T6141	8255-8258	NN	denotes	PRC
T6142	8258-8260	,	denotes	,
T6143	8260-8263	VBD	denotes	was
T6144	8264-8267	RB	denotes	not
T6145	8268-8281	RB	denotes	significantly
T6146	8290-8292	IN	denotes	in
T6147	8293-8298	NN	denotes	heart
T6148	8299-8301	IN	denotes	of
T6149	8302-8305	NN	denotes	PGC
T6150	8306-8308	NN	denotes	1α
T6151	8305-8306	HYPH	denotes	-
T6152	8312-8316	NNS	denotes	mice
T6153	8308-8309	SYM	denotes	−
T6154	8309-8310	HYPH	denotes	/
T6155	8310-8311	SYM	denotes	−
T6156	8317-8318	-LRB-	denotes	(
T6157	8325-8327	NN	denotes	1C
T6158	8318-8324	NN	denotes	Figure
T6159	8327-8328	-RRB-	denotes	)
T6160	8328-8329	.	denotes	.
T6161	8329-8446	sentence	denotes	Taken together, these results support the conclusion that the gene targeting event resulted in a PGC-1α null allele.
T6162	8330-8335	VBN	denotes	Taken
T6163	8360-8367	VBP	denotes	support
T6164	8336-8344	RB	denotes	together
T6165	8344-8346	,	denotes	,
T6166	8346-8351	DT	denotes	these
T6167	8352-8359	NNS	denotes	results
T6168	8368-8371	DT	denotes	the
T6169	8372-8382	NN	denotes	conclusion
T6170	8383-8387	IN	denotes	that
T6171	8413-8421	VBD	denotes	resulted
T6172	8388-8391	DT	denotes	the
T6173	8407-8412	NN	denotes	event
T6174	8392-8396	NN	denotes	gene
T6175	8397-8406	VBG	denotes	targeting
T6176	8422-8424	IN	denotes	in
T6177	8425-8426	DT	denotes	a
T6178	8439-8445	NN	denotes	allele
T6179	8427-8430	NN	denotes	PGC
T6180	8431-8433	NN	denotes	1α
T6181	8430-8431	HYPH	denotes	-
T6182	8434-8438	JJ	denotes	null
T6183	8445-8446	.	denotes	.
T7689	10877-10884	JJ	denotes	General
T7690	10885-10900	NNS	denotes	Characteristics
T7691	10901-10903	IN	denotes	of
T7692	10904-10907	DT	denotes	the
T7693	10918-10922	NNS	denotes	Mice
T7694	10908-10911	NN	denotes	PGC
T7695	10912-10914	NN	denotes	1α
T7696	10911-10912	HYPH	denotes	-
T7697	10914-10915	SYM	denotes	−
T7698	10915-10916	HYPH	denotes	/
T7699	10916-10917	SYM	denotes	−
T7700	10922-10924	:	denotes	:
T7701	10924-10927	NN	denotes	Age
T7702	10937-10946	JJ	denotes	Dependent
T7703	10927-10928	HYPH	denotes	-
T7704	10929-10932	CC	denotes	and
T7705	10933-10936	NN	denotes	Sex
T7706	10936-10937	HYPH	denotes	-
T7707	10947-10954	NN	denotes	Obesity
T7708	10954-11027	sentence	denotes	Heterozygous (PGC-1α+/−) mice were bred to generate PGC-1α−/− offspring.
T7709	10955-10967	JJ	denotes	Heterozygous
T7710	10980-10984	NNS	denotes	mice
T7711	10968-10969	-LRB-	denotes	(
T7712	10969-10972	NN	denotes	PGC
T7713	10973-10975	NN	denotes	1α
T7714	10972-10973	HYPH	denotes	-
T7715	10975-10976	SYM	denotes	+
T7716	10976-10977	HYPH	denotes	/
T7717	10977-10978	SYM	denotes	−
T7718	10978-10979	-RRB-	denotes	)
T7719	10990-10994	VBN	denotes	bred
T7720	10985-10989	VBD	denotes	were
T7721	10995-10997	TO	denotes	to
T7722	10998-11006	VB	denotes	generate
T7723	11007-11010	NN	denotes	PGC
T7724	11011-11013	NN	denotes	1α
T7725	11010-11011	HYPH	denotes	-
T7726	11017-11026	NN	denotes	offspring
T7727	11013-11014	SYM	denotes	−
T7728	11014-11015	HYPH	denotes	/
T7729	11015-11016	SYM	denotes	−
T7730	11026-11027	.	denotes	.
T7731	11027-11144	sentence	denotes	The observed genotype ratios of the offspring were consistent with the expected Mendelian ratios (unpublished data).
T7732	11028-11031	DT	denotes	The
T7733	11050-11056	NNS	denotes	ratios
T7734	11032-11040	VBN	denotes	observed
T7735	11041-11049	NN	denotes	genotype
T7736	11074-11078	VBD	denotes	were
T7737	11057-11059	IN	denotes	of
T7738	11060-11063	DT	denotes	the
T7739	11064-11073	NN	denotes	offspring
T7740	11079-11089	JJ	denotes	consistent
T7741	11090-11094	IN	denotes	with
T7742	11095-11098	DT	denotes	the
T7743	11118-11124	NNS	denotes	ratios
T7744	11099-11107	VBN	denotes	expected
T7745	11108-11117	JJ	denotes	Mendelian
T7746	11125-11126	-LRB-	denotes	(
T7747	11138-11142	NNS	denotes	data
T7748	11126-11137	JJ	denotes	unpublished
T7749	11142-11143	-RRB-	denotes	)
T7750	11143-11144	.	denotes	.
T7751	11144-11253	sentence	denotes	Unexpected deaths of the offspring were not observed, and PGC-1α+/− and PGC-1α−/− offspring appeared normal.
T7752	11145-11155	JJ	denotes	Unexpected
T7753	11156-11162	NNS	denotes	deaths
T7754	11189-11197	VBN	denotes	observed
T7755	11163-11165	IN	denotes	of
T7756	11166-11169	DT	denotes	the
T7757	11170-11179	NN	denotes	offspring
T7758	11180-11184	VBD	denotes	were
T7759	11185-11188	RB	denotes	not
T7760	11197-11199	,	denotes	,
T7761	11199-11202	CC	denotes	and
T7762	11203-11206	NN	denotes	PGC
T7763	11207-11209	NN	denotes	1α
T7764	11206-11207	HYPH	denotes	-
T7765	11227-11236	NN	denotes	offspring
T7766	11209-11210	SYM	denotes	+
T7767	11210-11211	HYPH	denotes	/
T7768	11211-11212	SYM	denotes	−
T7769	11213-11216	CC	denotes	and
T7770	11217-11220	NN	denotes	PGC
T7771	11221-11223	NN	denotes	1α
T7772	11220-11221	HYPH	denotes	-
T7773	11223-11224	SYM	denotes	−
T7774	11224-11225	HYPH	denotes	/
T7775	11225-11226	SYM	denotes	−
T7776	11237-11245	VBD	denotes	appeared
T7777	11246-11252	JJ	denotes	normal
T7778	11252-11253	.	denotes	.
T7779	11253-11439	sentence	denotes	Total body weights obtained 1 wk after birth revealed a 15%–20% reduction in total body mass for male and female PGC-1α−/− mice relative to sex-matched PGC-1α+/+ littermates (Figure 2).
T7780	11254-11259	JJ	denotes	Total
T7781	11265-11272	NNS	denotes	weights
T7782	11260-11264	NN	denotes	body
T7783	11299-11307	VBD	denotes	revealed
T7784	11273-11281	VBN	denotes	obtained
T7785	11282-11283	CD	denotes	1
T7786	11284-11286	NN	denotes	wk
T7787	11287-11292	IN	denotes	after
T7788	11293-11298	NN	denotes	birth
T7789	11308-11309	DT	denotes	a
T7790	11318-11327	NN	denotes	reduction
T7791	11310-11312	CD	denotes	15
T7792	11312-11313	NN	denotes	%
T7793	11313-11314	SYM	denotes	–
T7794	11316-11317	NN	denotes	%
T7795	11314-11316	CD	denotes	20
T7796	11328-11330	IN	denotes	in
T7797	11331-11336	JJ	denotes	total
T7798	11342-11346	NN	denotes	mass
T7799	11337-11341	NN	denotes	body
T7800	11347-11350	IN	denotes	for
T7801	11351-11355	JJ	denotes	male
T7802	11377-11381	NNS	denotes	mice
T7803	11356-11359	CC	denotes	and
T7804	11360-11366	JJ	denotes	female
T7805	11367-11370	NN	denotes	PGC
T7806	11371-11373	NN	denotes	1α
T7807	11370-11371	HYPH	denotes	-
T7808	11373-11374	SYM	denotes	−
T7809	11374-11375	HYPH	denotes	/
T7810	11375-11376	SYM	denotes	−
T7811	11382-11390	JJ	denotes	relative
T7812	11391-11393	IN	denotes	to
T7813	11394-11397	NN	denotes	sex
T7814	11398-11405	VBN	denotes	matched
T7815	11397-11398	HYPH	denotes	-
T7816	11416-11427	NNS	denotes	littermates
T7817	11406-11409	NN	denotes	PGC
T7818	11410-11412	NN	denotes	1α
T7819	11409-11410	HYPH	denotes	-
T7820	11412-11413	SYM	denotes	+
T7821	11413-11414	HYPH	denotes	/
T7822	11414-11415	SYM	denotes	+
T7823	11428-11429	-LRB-	denotes	(
T7824	11429-11435	NN	denotes	Figure
T7825	11436-11437	CD	denotes	2
T7826	11437-11438	-RRB-	denotes	)
T7827	11438-11439	.	denotes	.
T7828	11439-11544	sentence	denotes	The weight decrement between PGC-1α−/− and PGC-1α+/+ littermates disappeared by 3 wk of age (Figure 2A).
T7829	11440-11443	DT	denotes	The
T7830	11451-11460	NN	denotes	decrement
T7831	11444-11450	NN	denotes	weight
T7832	11505-11516	VBD	denotes	disappeared
T7833	11461-11468	IN	denotes	between
T7834	11469-11472	NN	denotes	PGC
T7835	11473-11475	NN	denotes	1α
T7836	11472-11473	HYPH	denotes	-
T7837	11493-11504	NNS	denotes	littermates
T7838	11475-11476	SYM	denotes	−
T7839	11476-11477	HYPH	denotes	/
T7840	11477-11478	SYM	denotes	−
T7841	11479-11482	CC	denotes	and
T7842	11483-11486	NN	denotes	PGC
T7843	11487-11489	NN	denotes	1α
T7844	11486-11487	HYPH	denotes	-
T7845	11489-11490	SYM	denotes	+
T7846	11490-11491	HYPH	denotes	/
T7847	11491-11492	SYM	denotes	+
T7848	11517-11519	IN	denotes	by
T7849	11520-11521	CD	denotes	3
T7850	11522-11524	NN	denotes	wk
T7851	11525-11527	IN	denotes	of
T7852	11528-11531	NN	denotes	age
T7853	11532-11533	-LRB-	denotes	(
T7854	11540-11542	NN	denotes	2A
T7855	11533-11539	NN	denotes	Figure
T7856	11542-11543	-RRB-	denotes	)
T7857	11543-11544	.	denotes	.
T7858	11544-11702	sentence	denotes	At 18 wk of age, body weight was modestly but significantly greater in male and female PGC-1α−/− mice compared to sex-matched PGC-1α+/+ controls (Figure 2A).
T7859	11545-11547	IN	denotes	At
T7860	11574-11577	VBD	denotes	was
T7861	11548-11550	CD	denotes	18
T7862	11551-11553	NN	denotes	wk
T7863	11554-11556	IN	denotes	of
T7864	11557-11560	NN	denotes	age
T7865	11560-11562	,	denotes	,
T7866	11562-11566	NN	denotes	body
T7867	11567-11573	NN	denotes	weight
T7868	11578-11586	RB	denotes	modestly
T7869	11605-11612	JJR	denotes	greater
T7870	11587-11590	CC	denotes	but
T7871	11591-11604	RB	denotes	significantly
T7872	11613-11615	IN	denotes	in
T7873	11616-11620	JJ	denotes	male
T7874	11642-11646	NNS	denotes	mice
T7875	11621-11624	CC	denotes	and
T7876	11625-11631	JJ	denotes	female
T7877	11632-11635	NN	denotes	PGC
T7878	11636-11638	NN	denotes	1α
T7879	11635-11636	HYPH	denotes	-
T7880	11638-11639	SYM	denotes	−
T7881	11639-11640	HYPH	denotes	/
T7882	11640-11641	SYM	denotes	−
T7883	11647-11655	VBN	denotes	compared
T7884	11656-11658	IN	denotes	to
T7885	11659-11662	NN	denotes	sex
T7886	11663-11670	VBN	denotes	matched
T7887	11662-11663	HYPH	denotes	-
T7888	11681-11689	NNS	denotes	controls
T7889	11671-11674	NN	denotes	PGC
T7890	11675-11677	NN	denotes	1α
T7891	11674-11675	HYPH	denotes	-
T7892	11677-11678	SYM	denotes	+
T7893	11678-11679	HYPH	denotes	/
T7894	11679-11680	SYM	denotes	+
T7895	11690-11691	-LRB-	denotes	(
T7896	11698-11700	NN	denotes	2A
T7897	11691-11697	NN	denotes	Figure
T7898	11700-11701	-RRB-	denotes	)
T7899	11701-11702	.	denotes	.
T7900	11702-11801	sentence	denotes	This weight difference was also significant for female PGC-1α−/− mice at 24 wk of age (Figure 2A).
T7901	11703-11707	DT	denotes	This
T7902	11715-11725	NN	denotes	difference
T7903	11708-11714	NN	denotes	weight
T7904	11726-11729	VBD	denotes	was
T7905	11730-11734	RB	denotes	also
T7906	11735-11746	JJ	denotes	significant
T7907	11747-11750	IN	denotes	for
T7908	11751-11757	JJ	denotes	female
T7909	11768-11772	NNS	denotes	mice
T7910	11758-11761	NN	denotes	PGC
T7911	11762-11764	NN	denotes	1α
T7912	11761-11762	HYPH	denotes	-
T7913	11764-11765	SYM	denotes	−
T7914	11765-11766	HYPH	denotes	/
T7915	11766-11767	SYM	denotes	−
T7916	11773-11775	IN	denotes	at
T7917	11776-11778	CD	denotes	24
T7918	11779-11781	NN	denotes	wk
T7919	11782-11784	IN	denotes	of
T7920	11785-11788	NN	denotes	age
T7921	11789-11790	-LRB-	denotes	(
T7922	11797-11799	NN	denotes	2A
T7923	11790-11796	NN	denotes	Figure
T7924	11799-11800	-RRB-	denotes	)
T7925	11800-11801	.	denotes	.
T7926	11801-11984	sentence	denotes	The abnormal weight gain in PGC-1α−/− mice was not associated with differences in food intake (unpublished data) or alterations in general activity as monitored for 48 h (Figure S1).
T7927	11802-11805	DT	denotes	The
T7928	11822-11826	NN	denotes	gain
T7929	11806-11814	JJ	denotes	abnormal
T7930	11815-11821	NN	denotes	weight
T7931	11853-11863	VBN	denotes	associated
T7932	11827-11829	IN	denotes	in
T7933	11830-11833	NN	denotes	PGC
T7934	11834-11836	NN	denotes	1α
T7935	11833-11834	HYPH	denotes	-
T7936	11840-11844	NNS	denotes	mice
T7937	11836-11837	SYM	denotes	−
T7938	11837-11838	HYPH	denotes	/
T7939	11838-11839	SYM	denotes	−
T7940	11845-11848	VBD	denotes	was
T7941	11849-11852	RB	denotes	not
T7942	11864-11868	IN	denotes	with
T7943	11869-11880	NNS	denotes	differences
T7944	11881-11883	IN	denotes	in
T7945	11884-11888	NN	denotes	food
T7946	11889-11895	NN	denotes	intake
T7947	11896-11897	-LRB-	denotes	(
T7948	11909-11913	NNS	denotes	data
T7949	11897-11908	JJ	denotes	unpublished
T7950	11913-11914	-RRB-	denotes	)
T7951	11915-11917	CC	denotes	or
T7952	11918-11929	NNS	denotes	alterations
T7953	11930-11932	IN	denotes	in
T7954	11933-11940	JJ	denotes	general
T7955	11941-11949	NN	denotes	activity
T7956	11950-11952	IN	denotes	as
T7957	11953-11962	VBN	denotes	monitored
T7958	11963-11966	IN	denotes	for
T7959	11967-11969	CD	denotes	48
T7960	11970-11971	NN	denotes	h
T7961	11972-11973	-LRB-	denotes	(
T7962	11980-11982	NN	denotes	S1
T7963	11973-11979	NN	denotes	Figure
T7964	11982-11983	-RRB-	denotes	)
T7965	11983-11984	.	denotes	.
T7966	11984-12271	sentence	denotes	Percent body fat, as determined by dual-energy X-ray absorption (DEXA), was greater in 18- and 24-wk-old female PGC-1α−/− mice compared to age-matched female PGC-1α+/+ counterparts, indicating that the body weight difference was due, at least in part, to increased body fat (Figure 2A).
T7967	11985-11992	NN	denotes	Percent
T7968	11998-12001	NN	denotes	fat
T7969	11993-11997	NN	denotes	body
T7970	12057-12060	VBD	denotes	was
T7971	12001-12003	,	denotes	,
T7972	12003-12005	IN	denotes	as
T7973	12006-12016	VBN	denotes	determined
T7974	12017-12019	IN	denotes	by
T7975	12020-12024	JJ	denotes	dual
T7976	12025-12031	NN	denotes	energy
T7977	12024-12025	HYPH	denotes	-
T7978	12038-12048	NN	denotes	absorption
T7979	12032-12037	NN	denotes	X-ray
T7980	12049-12050	-LRB-	denotes	(
T7981	12050-12054	NN	denotes	DEXA
T7982	12054-12055	-RRB-	denotes	)
T7983	12055-12057	,	denotes	,
T7984	12061-12068	JJR	denotes	greater
T7985	12069-12071	IN	denotes	in
T7986	12072-12074	CD	denotes	18
T7987	12083-12085	NN	denotes	wk
T7988	12074-12075	HYPH	denotes	-
T7989	12076-12079	CC	denotes	and
T7990	12080-12082	CD	denotes	24
T7991	12082-12083	HYPH	denotes	-
T7992	12086-12089	JJ	denotes	old
T7993	12085-12086	HYPH	denotes	-
T7994	12107-12111	NNS	denotes	mice
T7995	12090-12096	JJ	denotes	female
T7996	12097-12100	NN	denotes	PGC
T7997	12101-12103	NN	denotes	1α
T7998	12100-12101	HYPH	denotes	-
T7999	12103-12104	SYM	denotes	−
T8000	12104-12105	HYPH	denotes	/
T8001	12105-12106	SYM	denotes	−
T8002	12112-12120	VBN	denotes	compared
T8003	12121-12123	IN	denotes	to
T8004	12124-12127	NN	denotes	age
T8005	12128-12135	VBN	denotes	matched
T8006	12127-12128	HYPH	denotes	-
T8007	12153-12165	NNS	denotes	counterparts
T8008	12136-12142	JJ	denotes	female
T8009	12143-12146	NN	denotes	PGC
T8010	12147-12149	NN	denotes	1α
T8011	12146-12147	HYPH	denotes	-
T8012	12149-12150	SYM	denotes	+
T8013	12150-12151	HYPH	denotes	/
T8014	12151-12152	SYM	denotes	+
T8015	12165-12167	,	denotes	,
T8016	12167-12177	VBG	denotes	indicating
T8017	12178-12182	IN	denotes	that
T8018	12210-12213	VBD	denotes	was
T8019	12183-12186	DT	denotes	the
T8020	12199-12209	NN	denotes	difference
T8021	12187-12191	NN	denotes	body
T8022	12192-12198	NN	denotes	weight
T8023	12214-12217	IN	denotes	due
T8024	12217-12219	,	denotes	,
T8025	12219-12221	RB	denotes	at
T8026	12222-12227	RBS	denotes	least
T8027	12228-12230	IN	denotes	in
T8028	12231-12235	JJ	denotes	part
T8029	12235-12237	,	denotes	,
T8030	12237-12239	IN	denotes	to
T8031	12240-12249	VBN	denotes	increased
T8032	12255-12258	NN	denotes	fat
T8033	12250-12254	NN	denotes	body
T8034	12259-12260	-LRB-	denotes	(
T8035	12267-12269	NN	denotes	2A
T8036	12260-12266	NN	denotes	Figure
T8037	12269-12270	-RRB-	denotes	)
T8038	12270-12271	.	denotes	.
T8039	12271-12355	sentence	denotes	Lean mass was not significantly different between the genotypes (unpublished data).
T8040	12272-12276	JJ	denotes	Lean
T8041	12277-12281	NN	denotes	mass
T8042	12282-12285	VBD	denotes	was
T8043	12286-12289	RB	denotes	not
T8044	12290-12303	RB	denotes	significantly
T8045	12304-12313	JJ	denotes	different
T8046	12314-12321	IN	denotes	between
T8047	12322-12325	DT	denotes	the
T8048	12326-12335	NNS	denotes	genotypes
T8049	12336-12337	-LRB-	denotes	(
T8050	12349-12353	NNS	denotes	data
T8051	12337-12348	JJ	denotes	unpublished
T8052	12353-12354	-RRB-	denotes	)
T8053	12354-12355	.	denotes	.
T8054	12355-12570	sentence	denotes	Although DEXA did not detect excess body fat in male PGC-1α−/− mice at 18 or 24 wk of age, older male mutant mice (over 7 mo of age) accumulated more body fat than male WT controls (Figure 2A and unpublished data).
T8055	12356-12364	IN	denotes	Although
T8056	12378-12384	VB	denotes	detect
T8057	12365-12369	NN	denotes	DEXA
T8058	12370-12373	VBD	denotes	did
T8059	12374-12377	RB	denotes	not
T8060	12489-12500	VBD	denotes	accumulated
T8061	12385-12391	JJ	denotes	excess
T8062	12397-12400	NN	denotes	fat
T8063	12392-12396	NN	denotes	body
T8064	12401-12403	IN	denotes	in
T8065	12404-12408	JJ	denotes	male
T8066	12419-12423	NNS	denotes	mice
T8067	12409-12412	NN	denotes	PGC
T8068	12413-12415	NN	denotes	1α
T8069	12412-12413	HYPH	denotes	-
T8070	12415-12416	SYM	denotes	−
T8071	12416-12417	HYPH	denotes	/
T8072	12417-12418	SYM	denotes	−
T8073	12424-12426	IN	denotes	at
T8074	12427-12429	CD	denotes	18
T8075	12436-12438	NN	denotes	wk
T8076	12430-12432	CC	denotes	or
T8077	12433-12435	CD	denotes	24
T8078	12439-12441	IN	denotes	of
T8079	12442-12445	NN	denotes	age
T8080	12445-12447	,	denotes	,
T8081	12447-12452	JJR	denotes	older
T8082	12465-12469	NNS	denotes	mice
T8083	12453-12457	JJ	denotes	male
T8084	12458-12464	NN	denotes	mutant
T8085	12470-12471	-LRB-	denotes	(
T8086	12471-12475	IN	denotes	over
T8087	12476-12477	CD	denotes	7
T8088	12478-12480	NN	denotes	mo
T8089	12481-12483	IN	denotes	of
T8090	12484-12487	NN	denotes	age
T8091	12487-12488	-RRB-	denotes	)
T8092	12501-12505	JJR	denotes	more
T8093	12511-12514	NN	denotes	fat
T8094	12506-12510	NN	denotes	body
T8095	12515-12519	IN	denotes	than
T8096	12520-12524	JJ	denotes	male
T8097	12528-12536	NNS	denotes	controls
T8098	12525-12527	NN	denotes	WT
T8099	12537-12538	-LRB-	denotes	(
T8100	12545-12547	NN	denotes	2A
T8101	12538-12544	NN	denotes	Figure
T8102	12548-12551	CC	denotes	and
T8103	12552-12563	JJ	denotes	unpublished
T8104	12564-12568	NNS	denotes	data
T8105	12568-12569	-RRB-	denotes	)
T8106	12569-12570	.	denotes	.
T8107	12570-13721	sentence	denotes	Figure 2 Evidence for Tissue-Specific Growth Abnormalities and Mild Sex-Limited, Age-Dependent Obesity in PGC-1α−/− Mice (A) The bars represent total body weight for the ages indicated for male (left graph) and female (center graph) PGC-1α+/+ and PGC-1α−/− mice. The body weight (BW) of the 1-wk-old PGC-1α−/− mice was normalized to that of PGC-1α+/+ littermates, which was assigned a value of 100 (left axis). For the 3-, 18-, and 24-wk time points, absolute weights of PGC-1α−/− mice were compared to age-matched controls (right axis). Percent fat as determined by DEXA scanning for PGC-1α+/+ and PGC-1α−/− mice (right graph). The results represent n = 4 (males) and n ≥ 11 (females) for each genotype at 24 wk. * p < 0.05 compared to corresponding PGC-1α+/+ mice. (B) The bars represent organ weights corrected to body weight for 3-wk-old male and female PGC-1α+/+ and PGC-1α−/− mice. The error bars represent ± SEM. Results represent n ≥ 14 for each group. * p < 0.05 compared to corresponding PGC-1α+/+ mice. Individual organ weights were assessed, given the importance of mitochondrial energy metabolism for postnatal growth in certain organs.
T8108	13586-13596	JJ	denotes	Individual
T8109	13603-13610	NNS	denotes	weights
T8110	13597-13602	NN	denotes	organ
T8111	13616-13624	VBN	denotes	assessed
T8112	13611-13615	VBD	denotes	were
T8113	13624-13626	,	denotes	,
T8114	13626-13631	VBN	denotes	given
T8115	13632-13635	DT	denotes	the
T8116	13636-13646	NN	denotes	importance
T8117	13647-13649	IN	denotes	of
T8118	13650-13663	JJ	denotes	mitochondrial
T8119	13671-13681	NN	denotes	metabolism
T8120	13664-13670	NN	denotes	energy
T8121	13682-13685	IN	denotes	for
T8122	13686-13695	JJ	denotes	postnatal
T8123	13696-13702	NN	denotes	growth
T8124	13703-13705	IN	denotes	in
T8125	13706-13713	JJ	denotes	certain
T8126	13714-13720	NNS	denotes	organs
T8127	13720-13721	.	denotes	.
T8128	13721-14040	sentence	denotes	The weights of heart and slow-twitch fiber-enriched skeletal muscles, including gastrocnemius and soleus, but not the less oxidative tibialis anterior, were significantly lower in male and female PGC-1α−/− mice compared with age and sex-matched PGC-1α+/+ controls at 3 and 8 wk of age (Figure 2B and unpublished data).
T8129	13722-13725	DT	denotes	The
T8130	13726-13733	NNS	denotes	weights
T8131	13874-13878	VBD	denotes	were
T8132	13734-13736	IN	denotes	of
T8133	13737-13742	NN	denotes	heart
T8134	13743-13746	CC	denotes	and
T8135	13747-13751	JJ	denotes	slow
T8136	13752-13758	NN	denotes	twitch
T8137	13751-13752	HYPH	denotes	-
T8138	13783-13790	NNS	denotes	muscles
T8139	13759-13764	NN	denotes	fiber
T8140	13765-13773	VBN	denotes	enriched
T8141	13764-13765	HYPH	denotes	-
T8142	13774-13782	JJ	denotes	skeletal
T8143	13790-13792	,	denotes	,
T8144	13792-13801	VBG	denotes	including
T8145	13802-13815	NN	denotes	gastrocnemius
T8146	13816-13819	CC	denotes	and
T8147	13820-13826	NN	denotes	soleus
T8148	13826-13828	,	denotes	,
T8149	13828-13831	CC	denotes	but
T8150	13832-13835	RB	denotes	not
T8151	13836-13839	DT	denotes	the
T8152	13864-13872	NN	denotes	anterior
T8153	13840-13844	RBR	denotes	less
T8154	13845-13854	JJ	denotes	oxidative
T8155	13855-13863	NN	denotes	tibialis
T8156	13872-13874	,	denotes	,
T8157	13879-13892	RB	denotes	significantly
T8158	13893-13898	JJR	denotes	lower
T8159	13899-13901	IN	denotes	in
T8160	13902-13906	JJ	denotes	male
T8161	13928-13932	NNS	denotes	mice
T8162	13907-13910	CC	denotes	and
T8163	13911-13917	JJ	denotes	female
T8164	13918-13921	NN	denotes	PGC
T8165	13922-13924	NN	denotes	1α
T8166	13921-13922	HYPH	denotes	-
T8167	13924-13925	SYM	denotes	−
T8168	13925-13926	HYPH	denotes	/
T8169	13926-13927	SYM	denotes	−
T8170	13933-13941	VBN	denotes	compared
T8171	13942-13946	IN	denotes	with
T8172	13947-13950	NN	denotes	age
T8173	13959-13966	VBN	denotes	matched
T8174	13951-13954	CC	denotes	and
T8175	13955-13958	NN	denotes	sex
T8176	13958-13959	HYPH	denotes	-
T8177	13977-13985	NNS	denotes	controls
T8178	13967-13970	NN	denotes	PGC
T8179	13971-13973	NN	denotes	1α
T8180	13970-13971	HYPH	denotes	-
T8181	13973-13974	SYM	denotes	+
T8182	13974-13975	HYPH	denotes	/
T8183	13975-13976	SYM	denotes	+
T8184	13986-13988	IN	denotes	at
T8185	13989-13990	CD	denotes	3
T8186	13997-13999	NN	denotes	wk
T8187	13991-13994	CC	denotes	and
T8188	13995-13996	CD	denotes	8
T8189	14000-14002	IN	denotes	of
T8190	14003-14006	NN	denotes	age
T8191	14007-14008	-LRB-	denotes	(
T8192	14015-14017	NN	denotes	2B
T8193	14008-14014	NN	denotes	Figure
T8194	14018-14021	CC	denotes	and
T8195	14022-14033	JJ	denotes	unpublished
T8196	14034-14038	NNS	denotes	data
T8197	14038-14039	-RRB-	denotes	)
T8198	14039-14040	.	denotes	.
T8199	14040-14189	sentence	denotes	In contrast, the weights of brain, liver, kidney, and BAT were not significantly different between the genotypes at the 3-wk time point (Figure 2B).
T8200	14041-14043	IN	denotes	In
T8201	14099-14103	VBD	denotes	were
T8202	14044-14052	NN	denotes	contrast
T8203	14052-14054	,	denotes	,
T8204	14054-14057	DT	denotes	the
T8205	14058-14065	NNS	denotes	weights
T8206	14066-14068	IN	denotes	of
T8207	14069-14074	NN	denotes	brain
T8208	14074-14076	,	denotes	,
T8209	14076-14081	NN	denotes	liver
T8210	14081-14083	,	denotes	,
T8211	14083-14089	NN	denotes	kidney
T8212	14089-14091	,	denotes	,
T8213	14091-14094	CC	denotes	and
T8214	14095-14098	NN	denotes	BAT
T8215	14104-14107	RB	denotes	not
T8216	14108-14121	RB	denotes	significantly
T8217	14122-14131	JJ	denotes	different
T8218	14132-14139	IN	denotes	between
T8219	14140-14143	DT	denotes	the
T8220	14144-14153	NNS	denotes	genotypes
T8221	14154-14156	IN	denotes	at
T8222	14157-14160	DT	denotes	the
T8223	14171-14176	NN	denotes	point
T8224	14161-14162	CD	denotes	3
T8225	14163-14165	NN	denotes	wk
T8226	14162-14163	HYPH	denotes	-
T8227	14166-14170	NN	denotes	time
T8228	14177-14178	-LRB-	denotes	(
T8229	14185-14187	NN	denotes	2B
T8230	14178-14184	NN	denotes	Figure
T8231	14187-14188	-RRB-	denotes	)
T8232	14188-14189	.	denotes	.
T8233	14189-14352	sentence	denotes	Thus, certain tissues with high mitochondrial energy requirements, such as heart and slow-twitch skeletal muscle, exhibit modest growth defects in PGC-1α−/− mice.
T8234	14190-14194	RB	denotes	Thus
T8235	14304-14311	VBP	denotes	exhibit
T8236	14194-14196	,	denotes	,
T8237	14196-14203	JJ	denotes	certain
T8238	14204-14211	NNS	denotes	tissues
T8239	14212-14216	IN	denotes	with
T8240	14217-14221	JJ	denotes	high
T8241	14243-14255	NNS	denotes	requirements
T8242	14222-14235	JJ	denotes	mitochondrial
T8243	14236-14242	NN	denotes	energy
T8244	14255-14257	,	denotes	,
T8245	14257-14261	JJ	denotes	such
T8246	14262-14264	IN	denotes	as
T8247	14265-14270	NN	denotes	heart
T8248	14296-14302	NN	denotes	muscle
T8249	14271-14274	CC	denotes	and
T8250	14275-14279	JJ	denotes	slow
T8251	14280-14286	NN	denotes	twitch
T8252	14279-14280	HYPH	denotes	-
T8253	14287-14295	JJ	denotes	skeletal
T8254	14302-14304	,	denotes	,
T8255	14312-14318	JJ	denotes	modest
T8256	14326-14333	NNS	denotes	defects
T8257	14319-14325	NN	denotes	growth
T8258	14334-14336	IN	denotes	in
T8259	14337-14340	NN	denotes	PGC
T8260	14341-14343	NN	denotes	1α
T8261	14340-14341	HYPH	denotes	-
T8262	14347-14351	NNS	denotes	mice
T8263	14343-14344	SYM	denotes	−
T8264	14344-14345	HYPH	denotes	/
T8265	14345-14346	SYM	denotes	−
T8266	14351-14352	.	denotes	.
T9816	14354-14362	JJ	denotes	Abnormal
T9817	14384-14393	NN	denotes	Phenotype
T9818	14363-14369	NN	denotes	Muscle
T9819	14370-14383	JJ	denotes	Mitochondrial
T9820	14394-14396	IN	denotes	in
T9821	14397-14400	NN	denotes	PGC
T9822	14401-14403	NN	denotes	1α
T9823	14400-14401	HYPH	denotes	-
T9824	14407-14411	NNS	denotes	Mice
T9825	14403-14404	SYM	denotes	−
T9826	14404-14405	HYPH	denotes	/
T9827	14405-14406	SYM	denotes	−
T9828	14411-14566	sentence	denotes	General histologic analyses were performed to begin to evaluate the mild growth defect found in postnatal heart and skeletal muscle of the PGC-1α−/− mice.
T9829	14412-14419	JJ	denotes	General
T9830	14431-14439	NNS	denotes	analyses
T9831	14420-14430	JJ	denotes	histologic
T9832	14445-14454	VBN	denotes	performed
T9833	14440-14444	VBD	denotes	were
T9834	14455-14457	TO	denotes	to
T9835	14458-14463	VB	denotes	begin
T9836	14464-14466	TO	denotes	to
T9837	14467-14475	VB	denotes	evaluate
T9838	14476-14479	DT	denotes	the
T9839	14492-14498	NN	denotes	defect
T9840	14480-14484	JJ	denotes	mild
T9841	14485-14491	NN	denotes	growth
T9842	14499-14504	VBN	denotes	found
T9843	14505-14507	IN	denotes	in
T9844	14508-14517	JJ	denotes	postnatal
T9845	14518-14523	NN	denotes	heart
T9846	14524-14527	CC	denotes	and
T9847	14528-14536	JJ	denotes	skeletal
T9848	14537-14543	NN	denotes	muscle
T9849	14544-14546	IN	denotes	of
T9850	14547-14550	DT	denotes	the
T9851	14561-14565	NNS	denotes	mice
T9852	14551-14554	NN	denotes	PGC
T9853	14555-14557	NN	denotes	1α
T9854	14554-14555	HYPH	denotes	-
T9855	14557-14558	SYM	denotes	−
T9856	14558-14559	HYPH	denotes	/
T9857	14559-14560	SYM	denotes	−
T9858	14565-14566	.	denotes	.
T9859	14566-14717	sentence	denotes	There were no obvious abnormalities in cellularity, cell size, or extracellular matrix in the tissues of 1–2-mo-old PGC-1α−/− mice (unpublished data).
T9860	14567-14572	EX	denotes	There
T9861	14573-14577	VBD	denotes	were
T9862	14578-14580	DT	denotes	no
T9863	14589-14602	NNS	denotes	abnormalities
T9864	14581-14588	JJ	denotes	obvious
T9865	14603-14605	IN	denotes	in
T9866	14606-14617	NN	denotes	cellularity
T9867	14617-14619	,	denotes	,
T9868	14619-14623	NN	denotes	cell
T9869	14624-14628	NN	denotes	size
T9870	14628-14630	,	denotes	,
T9871	14630-14632	CC	denotes	or
T9872	14633-14646	JJ	denotes	extracellular
T9873	14647-14653	NN	denotes	matrix
T9874	14654-14656	IN	denotes	in
T9875	14657-14660	DT	denotes	the
T9876	14661-14668	NNS	denotes	tissues
T9877	14669-14671	IN	denotes	of
T9878	14672-14673	CD	denotes	1
T9879	14674-14675	CD	denotes	2
T9880	14673-14674	SYM	denotes	–
T9881	14676-14678	NN	denotes	mo
T9882	14675-14676	HYPH	denotes	-
T9883	14679-14682	JJ	denotes	old
T9884	14678-14679	HYPH	denotes	-
T9885	14693-14697	NNS	denotes	mice
T9886	14683-14686	NN	denotes	PGC
T9887	14687-14689	NN	denotes	1α
T9888	14686-14687	HYPH	denotes	-
T9889	14689-14690	SYM	denotes	−
T9890	14690-14691	HYPH	denotes	/
T9891	14691-14692	SYM	denotes	−
T9892	14698-14699	-LRB-	denotes	(
T9893	14711-14715	NNS	denotes	data
T9894	14699-14710	JJ	denotes	unpublished
T9895	14715-14716	-RRB-	denotes	)
T9896	14716-14717	.	denotes	.
T9897	14717-14860	sentence	denotes	Given the important role of PGC-1α in mitochondrial function and biogenesis, we examined mitochondrial ultrastructure in the relevant tissues.
T9898	14718-14723	VBN	denotes	Given
T9899	14798-14806	VBD	denotes	examined
T9900	14724-14727	DT	denotes	the
T9901	14738-14742	NN	denotes	role
T9902	14728-14737	JJ	denotes	important
T9903	14743-14745	IN	denotes	of
T9904	14746-14749	NN	denotes	PGC
T9905	14750-14752	NN	denotes	1α
T9906	14749-14750	HYPH	denotes	-
T9907	14753-14755	IN	denotes	in
T9908	14756-14769	JJ	denotes	mitochondrial
T9909	14770-14778	NN	denotes	function
T9910	14779-14782	CC	denotes	and
T9911	14783-14793	NN	denotes	biogenesis
T9912	14793-14795	,	denotes	,
T9913	14795-14797	PRP	denotes	we
T9914	14807-14820	JJ	denotes	mitochondrial
T9915	14821-14835	NN	denotes	ultrastructure
T9916	14836-14838	IN	denotes	in
T9917	14839-14842	DT	denotes	the
T9918	14852-14859	NNS	denotes	tissues
T9919	14843-14851	JJ	denotes	relevant
T9920	14859-14860	.	denotes	.
T9921	14860-15031	sentence	denotes	Electron microscopic analysis revealed fewer and smaller mitochondria in soleus muscle of PGC-1α−/− mice compared to sex- and age- matched PGC-1α+/+ controls (Figure 3A).
T9922	14861-14869	NN	denotes	Electron
T9923	14870-14881	JJ	denotes	microscopic
T9924	14882-14890	NN	denotes	analysis
T9925	14891-14899	VBD	denotes	revealed
T9926	14900-14905	JJR	denotes	fewer
T9927	14918-14930	NNS	denotes	mitochondria
T9928	14906-14909	CC	denotes	and
T9929	14910-14917	JJR	denotes	smaller
T9930	14931-14933	IN	denotes	in
T9931	14934-14940	NN	denotes	soleus
T9932	14941-14947	NN	denotes	muscle
T9933	14948-14950	IN	denotes	of
T9934	14951-14954	NN	denotes	PGC
T9935	14955-14957	NN	denotes	1α
T9936	14954-14955	HYPH	denotes	-
T9937	14961-14965	NNS	denotes	mice
T9938	14957-14958	SYM	denotes	−
T9939	14958-14959	HYPH	denotes	/
T9940	14959-14960	SYM	denotes	−
T9941	14966-14974	VBN	denotes	compared
T9942	14975-14977	IN	denotes	to
T9943	14978-14981	NN	denotes	sex
T9944	14992-14999	VBN	denotes	matched
T9945	14981-14982	HYPH	denotes	-
T9946	14983-14986	CC	denotes	and
T9947	14987-14990	NN	denotes	age
T9948	14990-14991	HYPH	denotes	-
T9949	15010-15018	NNS	denotes	controls
T9950	15000-15003	NN	denotes	PGC
T9951	15004-15006	NN	denotes	1α
T9952	15003-15004	HYPH	denotes	-
T9953	15006-15007	SYM	denotes	+
T9954	15007-15008	HYPH	denotes	/
T9955	15008-15009	SYM	denotes	+
T9956	15019-15020	-LRB-	denotes	(
T9957	15027-15029	NN	denotes	3A
T9958	15020-15026	NN	denotes	Figure
T9959	15029-15030	-RRB-	denotes	)
T9960	15030-15031	.	denotes	.
T9961	15031-15289	sentence	denotes	Quantitative morphometry of the electron micrographs confirmed that the cellular volume density of soleus mitochondria was significantly lower in PGC-1α−/− mice compared to PGC-1α+/+ controls independent of changes in the myofibrillar component (Figure 3B).
T9962	15032-15044	JJ	denotes	Quantitative
T9963	15045-15056	NN	denotes	morphometry
T9964	15085-15094	VBD	denotes	confirmed
T9965	15057-15059	IN	denotes	of
T9966	15060-15063	DT	denotes	the
T9967	15073-15084	NNS	denotes	micrographs
T9968	15064-15072	NN	denotes	electron
T9969	15095-15099	IN	denotes	that
T9970	15151-15154	VBD	denotes	was
T9971	15100-15103	DT	denotes	the
T9972	15120-15127	NN	denotes	density
T9973	15104-15112	JJ	denotes	cellular
T9974	15113-15119	NN	denotes	volume
T9975	15128-15130	IN	denotes	of
T9976	15131-15137	NN	denotes	soleus
T9977	15138-15150	NNS	denotes	mitochondria
T9978	15155-15168	RB	denotes	significantly
T9979	15169-15174	JJR	denotes	lower
T9980	15175-15177	IN	denotes	in
T9981	15178-15181	NN	denotes	PGC
T9982	15182-15184	NN	denotes	1α
T9983	15181-15182	HYPH	denotes	-
T9984	15188-15192	NNS	denotes	mice
T9985	15184-15185	SYM	denotes	−
T9986	15185-15186	HYPH	denotes	/
T9987	15186-15187	SYM	denotes	−
T9988	15193-15201	VBN	denotes	compared
T9989	15202-15204	IN	denotes	to
T9990	15205-15208	NN	denotes	PGC
T9991	15209-15211	NN	denotes	1α
T9992	15208-15209	HYPH	denotes	-
T9993	15215-15223	NNS	denotes	controls
T9994	15211-15212	SYM	denotes	+
T9995	15212-15213	HYPH	denotes	/
T9996	15213-15214	SYM	denotes	+
T9997	15224-15235	JJ	denotes	independent
T9998	15236-15238	IN	denotes	of
T9999	15239-15246	NNS	denotes	changes
T10000	15247-15249	IN	denotes	in
T10001	15250-15253	DT	denotes	the
T10002	15267-15276	NN	denotes	component
T10003	15254-15266	JJ	denotes	myofibrillar
T10004	15277-15278	-LRB-	denotes	(
T10005	15285-15287	NN	denotes	3B
T10006	15278-15284	NN	denotes	Figure
T10007	15287-15288	-RRB-	denotes	)
T10008	15288-15289	.	denotes	.
T10009	15289-15633	sentence	denotes	Consistent with a defect in mitochondrial biogenesis, we found a reduction in the expression of nuclear genes encoding proteins involved in mitochondrial electron transport (cytochrome c and cytochrome oxidase IV) and oxidative phosphorylation (beta subunit of ATP synthase) in soleus muscle of PGC-1α−/− mice compared with PGC-1α+/+ controls.
T10010	15290-15300	JJ	denotes	Consistent
T10011	15347-15352	VBD	denotes	found
T10012	15301-15305	IN	denotes	with
T10013	15306-15307	DT	denotes	a
T10014	15308-15314	NN	denotes	defect
T10015	15315-15317	IN	denotes	in
T10016	15318-15331	JJ	denotes	mitochondrial
T10017	15332-15342	NN	denotes	biogenesis
T10018	15342-15344	,	denotes	,
T10019	15344-15346	PRP	denotes	we
T10020	15353-15354	DT	denotes	a
T10021	15355-15364	NN	denotes	reduction
T10022	15365-15367	IN	denotes	in
T10023	15368-15371	DT	denotes	the
T10024	15372-15382	NN	denotes	expression
T10025	15383-15385	IN	denotes	of
T10026	15386-15393	JJ	denotes	nuclear
T10027	15394-15399	NNS	denotes	genes
T10028	15400-15408	VBG	denotes	encoding
T10029	15409-15417	NN	denotes	proteins
T10030	15418-15426	VBN	denotes	involved
T10031	15427-15429	IN	denotes	in
T10032	15430-15443	JJ	denotes	mitochondrial
T10033	15453-15462	NN	denotes	transport
T10034	15444-15452	NN	denotes	electron
T10035	15463-15464	-LRB-	denotes	(
T10036	15464-15474	NN	denotes	cytochrome
T10037	15475-15476	NN	denotes	c
T10038	15477-15480	CC	denotes	and
T10039	15481-15491	NN	denotes	cytochrome
T10040	15492-15499	NN	denotes	oxidase
T10041	15500-15502	CD	denotes	IV
T10042	15502-15503	-RRB-	denotes	)
T10043	15504-15507	CC	denotes	and
T10044	15508-15517	JJ	denotes	oxidative
T10045	15518-15533	NN	denotes	phosphorylation
T10046	15534-15535	-LRB-	denotes	(
T10047	15535-15539	NN	denotes	beta
T10048	15540-15547	NN	denotes	subunit
T10049	15548-15550	IN	denotes	of
T10050	15551-15554	NN	denotes	ATP
T10051	15555-15563	NN	denotes	synthase
T10052	15563-15564	-RRB-	denotes	)
T10053	15565-15567	IN	denotes	in
T10054	15568-15574	NN	denotes	soleus
T10055	15575-15581	NN	denotes	muscle
T10056	15582-15584	IN	denotes	of
T10057	15585-15588	NN	denotes	PGC
T10058	15589-15591	NN	denotes	1α
T10059	15588-15589	HYPH	denotes	-
T10060	15595-15599	NNS	denotes	mice
T10061	15591-15592	SYM	denotes	−
T10062	15592-15593	HYPH	denotes	/
T10063	15593-15594	SYM	denotes	−
T10064	15600-15608	VBN	denotes	compared
T10065	15609-15613	IN	denotes	with
T10066	15614-15617	NN	denotes	PGC
T10067	15618-15620	NN	denotes	1α
T10068	15617-15618	HYPH	denotes	-
T10069	15624-15632	NNS	denotes	controls
T10070	15620-15621	SYM	denotes	+
T10071	15621-15622	HYPH	denotes	/
T10072	15622-15623	SYM	denotes	+
T10073	15632-15633	.	denotes	.
T10074	15633-15871	sentence	denotes	In addition, the expression of Tfam, a known PGC-1α target involved in mitochondrial DNA replication/transcription, was diminished in PGC-1α−/− soleus, providing one potential mechanism for defective mitochondrial biogenesis (Figure 3C).
T10075	15634-15636	IN	denotes	In
T10076	15754-15764	VBN	denotes	diminished
T10077	15637-15645	NN	denotes	addition
T10078	15645-15647	,	denotes	,
T10079	15647-15650	DT	denotes	the
T10080	15651-15661	NN	denotes	expression
T10081	15662-15664	IN	denotes	of
T10082	15665-15669	NN	denotes	Tfam
T10083	15669-15671	,	denotes	,
T10084	15671-15672	DT	denotes	a
T10085	15686-15692	NN	denotes	target
T10086	15673-15678	JJ	denotes	known
T10087	15679-15682	NN	denotes	PGC
T10088	15683-15685	NN	denotes	1α
T10089	15682-15683	HYPH	denotes	-
T10090	15693-15701	VBN	denotes	involved
T10091	15702-15704	IN	denotes	in
T10092	15705-15718	JJ	denotes	mitochondrial
T10093	15735-15748	NN	denotes	transcription
T10094	15719-15722	NN	denotes	DNA
T10095	15723-15734	NN	denotes	replication
T10096	15734-15735	HYPH	denotes	/
T10097	15748-15750	,	denotes	,
T10098	15750-15753	VBD	denotes	was
T10099	15765-15767	IN	denotes	in
T10100	15768-15771	NN	denotes	PGC
T10101	15772-15774	NN	denotes	1α
T10102	15771-15772	HYPH	denotes	-
T10103	15778-15784	NN	denotes	soleus
T10104	15774-15775	SYM	denotes	−
T10105	15775-15776	HYPH	denotes	/
T10106	15776-15777	SYM	denotes	−
T10107	15784-15786	,	denotes	,
T10108	15786-15795	VBG	denotes	providing
T10109	15796-15799	CD	denotes	one
T10110	15810-15819	NN	denotes	mechanism
T10111	15800-15809	JJ	denotes	potential
T10112	15820-15823	IN	denotes	for
T10113	15824-15833	JJ	denotes	defective
T10114	15848-15858	NN	denotes	biogenesis
T10115	15834-15847	JJ	denotes	mitochondrial
T10116	15859-15860	-LRB-	denotes	(
T10117	15867-15869	NN	denotes	3C
T10118	15860-15866	NN	denotes	Figure
T10119	15869-15870	-RRB-	denotes	)
T10120	15870-15871	.	denotes	.
T10121	15871-16053	sentence	denotes	In contrast to the results with soleus, no significant differences in mitochondrial ultrastructure or volume density were noted in heart or BAT of PGC-1α−/− mice (unpublished data).
T10122	15872-15874	IN	denotes	In
T10123	15994-15999	VBN	denotes	noted
T10124	15875-15883	NN	denotes	contrast
T10125	15884-15886	IN	denotes	to
T10126	15887-15890	DT	denotes	the
T10127	15891-15898	NNS	denotes	results
T10128	15899-15903	IN	denotes	with
T10129	15904-15910	NN	denotes	soleus
T10130	15910-15912	,	denotes	,
T10131	15912-15914	DT	denotes	no
T10132	15927-15938	NNS	denotes	differences
T10133	15915-15926	JJ	denotes	significant
T10134	15939-15941	IN	denotes	in
T10135	15942-15955	JJ	denotes	mitochondrial
T10136	15956-15970	NN	denotes	ultrastructure
T10137	15971-15973	CC	denotes	or
T10138	15974-15980	NN	denotes	volume
T10139	15981-15988	NN	denotes	density
T10140	15989-15993	VBD	denotes	were
T10141	16000-16002	IN	denotes	in
T10142	16003-16008	NN	denotes	heart
T10143	16009-16011	CC	denotes	or
T10144	16012-16015	NN	denotes	BAT
T10145	16016-16018	IN	denotes	of
T10146	16019-16022	NN	denotes	PGC
T10147	16023-16025	NN	denotes	1α
T10148	16022-16023	HYPH	denotes	-
T10149	16029-16033	NNS	denotes	mice
T10150	16025-16026	SYM	denotes	−
T10151	16026-16027	HYPH	denotes	/
T10152	16027-16028	SYM	denotes	−
T10153	16034-16035	-LRB-	denotes	(
T10154	16047-16051	NNS	denotes	data
T10155	16035-16046	JJ	denotes	unpublished
T10156	16051-16052	-RRB-	denotes	)
T10157	16052-16053	.	denotes	.
T10158	16053-17691	sentence	denotes	Figure 3 Abnormal Mitochondrial Phenotype in Slow-Twitch Skeletal Muscle of PGC-1α−/− Mice (A) Representative electron micrograph of soleus muscle from 1-mo-old female PGC-1α+/+ and PGC-1α−/− mice. (B) Quantitative morphometric measurements of the cellular volume density for the mitochondrial (Mito) and myofibrillar (Myo) fractions based on analysis of electron micrographs (three sections from three animals per group). The bars represent mean ± SEM. * p < 0.05 compared to corresponding PGC-1α+/+ values. (C) Gene expression data. The results of real-time PCR analysis of nuclear and mitochondrial genes involved in various components of mitochondrial metabolism and mitochondrial biogenesis: cytochrome C (Cyto c), ATP synthase β, Tfam, and cytochrome oxidase IV (COX IV). Eight littermate pairs were used for analysis at 1–2 mo of age and normalized to the WT value, which was assigned a value of 100, in each case. * p < 0.05 compared to corresponding PGC-1α+/+ values. (D) Mitochondrial respiration rates as determined by oxygen consumption (VO2) performed on saponin-permeabilized muscle strips prepared from soleus of PGC-1α+/+ and PGC-1α−/− mice (as described in Materials and Methods). The results are based on six female animals in each group, using succinate as a substrate in the presence of rotenone. Mean values (± SEM) are shown for state 2 (basal), state 3 (ADP-stimulated), and state 4 respiration (presence of oligomycin). To determine whether mitochondrial function was altered in the skeletal muscle of PGC-1α−/− mice, mitochondrial respiration rates were measured using tissue strips prepared from soleus muscle.
T10159	17499-17501	TO	denotes	To
T10160	17502-17511	VB	denotes	determine
T10161	17634-17642	VBN	denotes	measured
T10162	17512-17519	IN	denotes	whether
T10163	17547-17554	VBN	denotes	altered
T10164	17520-17533	JJ	denotes	mitochondrial
T10165	17534-17542	NN	denotes	function
T10166	17543-17546	VBD	denotes	was
T10167	17555-17557	IN	denotes	in
T10168	17558-17561	DT	denotes	the
T10169	17571-17577	NN	denotes	muscle
T10170	17562-17570	JJ	denotes	skeletal
T10171	17578-17580	IN	denotes	of
T10172	17581-17584	NN	denotes	PGC
T10173	17585-17587	NN	denotes	1α
T10174	17584-17585	HYPH	denotes	-
T10175	17591-17595	NNS	denotes	mice
T10176	17587-17588	SYM	denotes	−
T10177	17588-17589	HYPH	denotes	/
T10178	17589-17590	SYM	denotes	−
T10179	17595-17597	,	denotes	,
T10180	17597-17610	JJ	denotes	mitochondrial
T10181	17623-17628	NNS	denotes	rates
T10182	17611-17622	NN	denotes	respiration
T10183	17629-17633	VBD	denotes	were
T10184	17643-17648	VBG	denotes	using
T10185	17649-17655	NN	denotes	tissue
T10186	17656-17662	NNS	denotes	strips
T10187	17663-17671	VBN	denotes	prepared
T10188	17672-17676	IN	denotes	from
T10189	17677-17683	NN	denotes	soleus
T10190	17684-17690	NN	denotes	muscle
T10191	17690-17691	.	denotes	.
T10192	17691-17866	sentence	denotes	In soleus of PGC-1α−/− mice, a significant defect in state 3 (ADP-stimulated) respiration, but not state 2 (basal), was detected using succinate as the substrate (Figure 3D).
T10193	17692-17694	IN	denotes	In
T10194	17812-17820	VBN	denotes	detected
T10195	17695-17701	NN	denotes	soleus
T10196	17702-17704	IN	denotes	of
T10197	17705-17708	NN	denotes	PGC
T10198	17709-17711	NN	denotes	1α
T10199	17708-17709	HYPH	denotes	-
T10200	17715-17719	NNS	denotes	mice
T10201	17711-17712	SYM	denotes	−
T10202	17712-17713	HYPH	denotes	/
T10203	17713-17714	SYM	denotes	−
T10204	17719-17721	,	denotes	,
T10205	17721-17722	DT	denotes	a
T10206	17735-17741	NN	denotes	defect
T10207	17723-17734	JJ	denotes	significant
T10208	17742-17744	IN	denotes	in
T10209	17745-17750	NN	denotes	state
T10210	17770-17781	NN	denotes	respiration
T10211	17751-17752	CD	denotes	3
T10212	17753-17754	-LRB-	denotes	(
T10213	17758-17768	VBN	denotes	stimulated
T10214	17754-17757	NN	denotes	ADP
T10215	17757-17758	HYPH	denotes	-
T10216	17768-17769	-RRB-	denotes	)
T10217	17781-17783	,	denotes	,
T10218	17783-17786	CC	denotes	but
T10219	17787-17790	RB	denotes	not
T10220	17791-17796	NN	denotes	state
T10221	17797-17798	CD	denotes	2
T10222	17799-17800	-LRB-	denotes	(
T10223	17800-17805	JJ	denotes	basal
T10224	17805-17806	-RRB-	denotes	)
T10225	17806-17808	,	denotes	,
T10226	17808-17811	VBD	denotes	was
T10227	17821-17826	VBG	denotes	using
T10228	17827-17836	NN	denotes	succinate
T10229	17837-17839	IN	denotes	as
T10230	17840-17843	DT	denotes	the
T10231	17844-17853	NN	denotes	substrate
T10232	17854-17855	-LRB-	denotes	(
T10233	17862-17864	NN	denotes	3D
T10234	17855-17861	NN	denotes	Figure
T10235	17864-17865	-RRB-	denotes	)
T10236	17865-17866	.	denotes	.
T10237	17866-18076	sentence	denotes	State 4 respiration rates (in the presence of oligomycin) were also similar between the genotypes, indicating that the coupling of respiration to ATP production was not significantly altered in PGC-1α−/− mice.
T10238	17867-17872	NN	denotes	State
T10239	17887-17892	NNS	denotes	rates
T10240	17873-17874	CD	denotes	4
T10241	17875-17886	NN	denotes	respiration
T10242	17925-17929	VBD	denotes	were
T10243	17893-17894	-LRB-	denotes	(
T10244	17894-17896	IN	denotes	in
T10245	17897-17900	DT	denotes	the
T10246	17901-17909	NN	denotes	presence
T10247	17910-17912	IN	denotes	of
T10248	17913-17923	NN	denotes	oligomycin
T10249	17923-17924	-RRB-	denotes	)
T10250	17930-17934	RB	denotes	also
T10251	17935-17942	JJ	denotes	similar
T10252	17943-17950	IN	denotes	between
T10253	17951-17954	DT	denotes	the
T10254	17955-17964	NNS	denotes	genotypes
T10255	17964-17966	,	denotes	,
T10256	17966-17976	VBG	denotes	indicating
T10257	17977-17981	IN	denotes	that
T10258	18050-18057	VBN	denotes	altered
T10259	17982-17985	DT	denotes	the
T10260	17986-17994	NN	denotes	coupling
T10261	17995-17997	IN	denotes	of
T10262	17998-18009	NN	denotes	respiration
T10263	18010-18012	IN	denotes	to
T10264	18013-18016	NN	denotes	ATP
T10265	18017-18027	NN	denotes	production
T10266	18028-18031	VBD	denotes	was
T10267	18032-18035	RB	denotes	not
T10268	18036-18049	RB	denotes	significantly
T10269	18058-18060	IN	denotes	in
T10270	18061-18064	NN	denotes	PGC
T10271	18065-18067	NN	denotes	1α
T10272	18064-18065	HYPH	denotes	-
T10273	18071-18075	NNS	denotes	mice
T10274	18067-18068	SYM	denotes	−
T10275	18068-18069	HYPH	denotes	/
T10276	18069-18070	SYM	denotes	−
T10277	18075-18076	.	denotes	.
T10278	18076-18180	sentence	denotes	These results are consistent with the modest but significant reduction in mitochondrial volume density.
T10279	18077-18082	DT	denotes	These
T10280	18083-18090	NNS	denotes	results
T10281	18091-18094	VBP	denotes	are
T10282	18095-18105	JJ	denotes	consistent
T10283	18106-18110	IN	denotes	with
T10284	18111-18114	DT	denotes	the
T10285	18138-18147	NN	denotes	reduction
T10286	18115-18121	JJ	denotes	modest
T10287	18122-18125	CC	denotes	but
T10288	18126-18137	JJ	denotes	significant
T10289	18148-18150	IN	denotes	in
T10290	18151-18164	JJ	denotes	mitochondrial
T10291	18172-18179	NN	denotes	density
T10292	18165-18171	NN	denotes	volume
T10293	18179-18180	.	denotes	.
T12484	18182-18189	VBN	denotes	Altered
T12485	18206-18214	NN	denotes	Function
T12486	18190-18198	JJ	denotes	Skeletal
T12487	18199-18205	NN	denotes	Muscle
T12488	18215-18217	IN	denotes	in
T12489	18218-18221	NN	denotes	PGC
T12490	18222-18224	NN	denotes	1α
T12491	18221-18222	HYPH	denotes	-
T12492	18228-18232	NNS	denotes	Mice
T12493	18224-18225	SYM	denotes	−
T12494	18225-18226	HYPH	denotes	/
T12495	18226-18227	SYM	denotes	−
T12496	18232-18374	sentence	denotes	The abnormality in mitochondrial number and respiratory function in skeletal muscle led us to further evaluate the skeletal muscle phenotype.
T12497	18233-18236	DT	denotes	The
T12498	18237-18248	NN	denotes	abnormality
T12499	18317-18320	VBD	denotes	led
T12500	18249-18251	IN	denotes	in
T12501	18252-18265	JJ	denotes	mitochondrial
T12502	18266-18272	NN	denotes	number
T12503	18273-18276	CC	denotes	and
T12504	18277-18288	JJ	denotes	respiratory
T12505	18289-18297	NN	denotes	function
T12506	18298-18300	IN	denotes	in
T12507	18301-18309	JJ	denotes	skeletal
T12508	18310-18316	NN	denotes	muscle
T12509	18321-18323	PRP	denotes	us
T12510	18324-18326	TO	denotes	to
T12511	18335-18343	VB	denotes	evaluate
T12512	18327-18334	RB	denotes	further
T12513	18344-18347	DT	denotes	the
T12514	18364-18373	NN	denotes	phenotype
T12515	18348-18356	JJ	denotes	skeletal
T12516	18357-18363	NN	denotes	muscle
T12517	18373-18374	.	denotes	.
T12518	18374-18492	sentence	denotes	As an initial step, we measured locomotor activity levels over a 1-h period using a high-resolution photobeam system.
T12519	18375-18377	IN	denotes	As
T12520	18398-18406	VBD	denotes	measured
T12521	18378-18380	DT	denotes	an
T12522	18389-18393	NN	denotes	step
T12523	18381-18388	JJ	denotes	initial
T12524	18393-18395	,	denotes	,
T12525	18395-18397	PRP	denotes	we
T12526	18407-18416	NN	denotes	locomotor
T12527	18426-18432	NNS	denotes	levels
T12528	18417-18425	NN	denotes	activity
T12529	18433-18437	IN	denotes	over
T12530	18438-18439	DT	denotes	a
T12531	18444-18450	NN	denotes	period
T12532	18440-18441	CD	denotes	1
T12533	18442-18443	NN	denotes	h
T12534	18441-18442	HYPH	denotes	-
T12535	18451-18456	VBG	denotes	using
T12536	18457-18458	DT	denotes	a
T12537	18485-18491	NN	denotes	system
T12538	18459-18463	JJ	denotes	high
T12539	18464-18474	NN	denotes	resolution
T12540	18463-18464	HYPH	denotes	-
T12541	18475-18484	NN	denotes	photobeam
T12542	18491-18492	.	denotes	.
T12543	18492-18659	sentence	denotes	PGC-1α−/− male mice exhibited a significantly lower mean number of ambulations and rearings during the hour compared to the PGC-1α+/+ age-matched controls (Figure 4).
T12544	18493-18496	NN	denotes	PGC
T12545	18497-18499	NN	denotes	1α
T12546	18496-18497	HYPH	denotes	-
T12547	18508-18512	NNS	denotes	mice
T12548	18499-18500	SYM	denotes	−
T12549	18500-18501	HYPH	denotes	/
T12550	18501-18502	SYM	denotes	−
T12551	18503-18507	JJ	denotes	male
T12552	18513-18522	VBD	denotes	exhibited
T12553	18523-18524	DT	denotes	a
T12554	18550-18556	NN	denotes	number
T12555	18525-18538	RB	denotes	significantly
T12556	18539-18544	JJR	denotes	lower
T12557	18545-18549	JJ	denotes	mean
T12558	18557-18559	IN	denotes	of
T12559	18560-18571	NNS	denotes	ambulations
T12560	18572-18575	CC	denotes	and
T12561	18576-18584	NNS	denotes	rearings
T12562	18585-18591	IN	denotes	during
T12563	18592-18595	DT	denotes	the
T12564	18596-18600	NN	denotes	hour
T12565	18601-18609	VBN	denotes	compared
T12566	18610-18612	IN	denotes	to
T12567	18613-18616	DT	denotes	the
T12568	18639-18647	NNS	denotes	controls
T12569	18617-18620	NN	denotes	PGC
T12570	18621-18623	NN	denotes	1α
T12571	18620-18621	HYPH	denotes	-
T12572	18623-18624	SYM	denotes	+
T12573	18624-18625	HYPH	denotes	/
T12574	18625-18626	SYM	denotes	+
T12575	18627-18630	NN	denotes	age
T12576	18631-18638	VBN	denotes	matched
T12577	18630-18631	HYPH	denotes	-
T12578	18648-18649	-LRB-	denotes	(
T12579	18649-18655	NN	denotes	Figure
T12580	18656-18657	CD	denotes	4
T12581	18657-18658	-RRB-	denotes	)
T12582	18658-18659	.	denotes	.
T12583	18659-18809	sentence	denotes	However, an analysis of exploratory behavior showed that the PGC-1α−/− mice were reluctant to go into the center of the “field” compared to controls.
T12584	18660-18667	RB	denotes	However
T12585	18705-18711	VBD	denotes	showed
T12586	18667-18669	,	denotes	,
T12587	18669-18671	DT	denotes	an
T12588	18672-18680	NN	denotes	analysis
T12589	18681-18683	IN	denotes	of
T12590	18684-18695	JJ	denotes	exploratory
T12591	18696-18704	NN	denotes	behavior
T12592	18712-18716	IN	denotes	that
T12593	18736-18740	VBD	denotes	were
T12594	18717-18720	DT	denotes	the
T12595	18731-18735	NNS	denotes	mice
T12596	18721-18724	NN	denotes	PGC
T12597	18725-18727	NN	denotes	1α
T12598	18724-18725	HYPH	denotes	-
T12599	18727-18728	SYM	denotes	−
T12600	18728-18729	HYPH	denotes	/
T12601	18729-18730	SYM	denotes	−
T12602	18741-18750	JJ	denotes	reluctant
T12603	18751-18753	TO	denotes	to
T12604	18754-18756	VB	denotes	go
T12605	18757-18761	IN	denotes	into
T12606	18762-18765	DT	denotes	the
T12607	18766-18772	NN	denotes	center
T12608	18773-18775	IN	denotes	of
T12609	18776-18779	DT	denotes	the
T12610	18781-18786	NN	denotes	field
T12611	18780-18781	``	denotes	“
T12612	18786-18787	''	denotes	”
T12613	18788-18796	VBN	denotes	compared
T12614	18797-18799	IN	denotes	to
T12615	18800-18808	NNS	denotes	controls
T12616	18808-18809	.	denotes	.
T12617	18809-19133	sentence	denotes	Specifically, PGC-1α−/− mice made significantly fewer entries into, spent significantly less time in, and traveled a significantly shorter distance in the central area of the “field,” although differences in distance traveled in the peripheral zone of the “field” was not significantly different between groups (Figure S2).
T12618	18810-18822	RB	denotes	Specifically
T12619	18986-18991	NN	denotes	field
T12620	18822-18824	,	denotes	,
T12621	18824-18827	NN	denotes	PGC
T12622	18828-18830	NN	denotes	1α
T12623	18827-18828	HYPH	denotes	-
T12624	18834-18838	NNS	denotes	mice
T12625	18830-18831	SYM	denotes	−
T12626	18831-18832	HYPH	denotes	/
T12627	18832-18833	SYM	denotes	−
T12628	18839-18843	VBD	denotes	made
T12629	18844-18857	RB	denotes	significantly
T12630	18858-18863	JJR	denotes	fewer
T12631	18864-18871	NNS	denotes	entries
T12632	18872-18876	IN	denotes	into
T12633	18876-18878	,	denotes	,
T12634	18878-18883	VBD	denotes	spent
T12635	18884-18897	RB	denotes	significantly
T12636	18898-18902	JJR	denotes	less
T12637	18903-18907	NN	denotes	time
T12638	18908-18910	IN	denotes	in
T12639	18910-18912	,	denotes	,
T12640	18912-18915	CC	denotes	and
T12641	18916-18924	VBD	denotes	traveled
T12642	18925-18926	DT	denotes	a
T12643	18949-18957	NN	denotes	distance
T12644	18927-18940	RB	denotes	significantly
T12645	18941-18948	JJR	denotes	shorter
T12646	18958-18960	IN	denotes	in
T12647	18961-18964	DT	denotes	the
T12648	18973-18977	NN	denotes	area
T12649	18965-18972	JJ	denotes	central
T12650	18978-18980	IN	denotes	of
T12651	18981-18984	DT	denotes	the
T12652	18985-18986	``	denotes	“
T12653	18991-18992	,	denotes	,
T12654	18992-18993	''	denotes	”
T12655	18994-19002	IN	denotes	although
T12656	19074-19077	VBD	denotes	was
T12657	19003-19014	NNS	denotes	differences
T12658	19015-19017	IN	denotes	in
T12659	19018-19026	NN	denotes	distance
T12660	19027-19035	VBN	denotes	traveled
T12661	19036-19038	IN	denotes	in
T12662	19039-19042	DT	denotes	the
T12663	19054-19058	NN	denotes	zone
T12664	19043-19053	JJ	denotes	peripheral
T12665	19059-19061	IN	denotes	of
T12666	19062-19065	DT	denotes	the
T12667	19067-19072	NN	denotes	field
T12668	19066-19067	``	denotes	“
T12669	19072-19073	''	denotes	”
T12670	19078-19081	RB	denotes	not
T12671	19082-19095	RB	denotes	significantly
T12672	19096-19105	JJ	denotes	different
T12673	19106-19113	IN	denotes	between
T12674	19114-19120	NNS	denotes	groups
T12675	19121-19122	-LRB-	denotes	(
T12676	19129-19131	NN	denotes	S2
T12677	19122-19128	NN	denotes	Figure
T12678	19131-19132	-RRB-	denotes	)
T12679	19132-19133	.	denotes	.
T12680	19133-19401	sentence	denotes	These data suggest that the general activity level may have been affected by the reluctance of the PGC-1α−/− mice to go into the central area of the field and thus remain in the periphery (thigmotaxis), possibly reflecting altered emotionality such as increased fear.
T12681	19134-19139	DT	denotes	These
T12682	19140-19144	NNS	denotes	data
T12683	19145-19152	VBP	denotes	suggest
T12684	19153-19157	IN	denotes	that
T12685	19199-19207	VBN	denotes	affected
T12686	19158-19161	DT	denotes	the
T12687	19179-19184	NN	denotes	level
T12688	19162-19169	JJ	denotes	general
T12689	19170-19178	NN	denotes	activity
T12690	19185-19188	MD	denotes	may
T12691	19189-19193	VB	denotes	have
T12692	19194-19198	VBN	denotes	been
T12693	19208-19210	IN	denotes	by
T12694	19211-19214	DT	denotes	the
T12695	19215-19225	NN	denotes	reluctance
T12696	19226-19228	IN	denotes	of
T12697	19229-19232	DT	denotes	the
T12698	19243-19247	NNS	denotes	mice
T12699	19233-19236	NN	denotes	PGC
T12700	19237-19239	NN	denotes	1α
T12701	19236-19237	HYPH	denotes	-
T12702	19239-19240	SYM	denotes	−
T12703	19240-19241	HYPH	denotes	/
T12704	19241-19242	SYM	denotes	−
T12705	19248-19250	TO	denotes	to
T12706	19251-19253	VB	denotes	go
T12707	19254-19258	IN	denotes	into
T12708	19259-19262	DT	denotes	the
T12709	19271-19275	NN	denotes	area
T12710	19263-19270	JJ	denotes	central
T12711	19276-19278	IN	denotes	of
T12712	19279-19282	DT	denotes	the
T12713	19283-19288	NN	denotes	field
T12714	19289-19292	CC	denotes	and
T12715	19293-19297	RB	denotes	thus
T12716	19298-19304	VB	denotes	remain
T12717	19305-19307	IN	denotes	in
T12718	19308-19311	DT	denotes	the
T12719	19312-19321	NN	denotes	periphery
T12720	19322-19323	-LRB-	denotes	(
T12721	19323-19334	NN	denotes	thigmotaxis
T12722	19334-19335	-RRB-	denotes	)
T12723	19335-19337	,	denotes	,
T12724	19337-19345	RB	denotes	possibly
T12725	19346-19356	VBG	denotes	reflecting
T12726	19357-19364	VBN	denotes	altered
T12727	19365-19377	NN	denotes	emotionality
T12728	19378-19382	JJ	denotes	such
T12729	19383-19385	IN	denotes	as
T12730	19386-19395	VBN	denotes	increased
T12731	19396-19400	NN	denotes	fear
T12732	19400-19401	.	denotes	.
T12733	19401-20943	sentence	denotes	Figure 4 PGC-1α−/− Mice Exhibit an Abnormal Skeletal Muscle Functional Phenotype (A) Measures of general activity and muscle strength. General activity levels were measured in 3.5-mo-old male PGC-1α+/+ (n = 8) and PGC-1α−/− (n = 11) mice using a photobeam system as described in Materials and Methods. Total ambulations (left graph), and rearings (center graph) provide a general measure of locomotor activity. Time spent on an inverted screen (right graph) represents a general measure of extremity muscle strength. The results from two trials are shown. * p < 0.05 compared to corresponding PGC-1α+/+. (B) Exercise studies. Male 6–8-mo-old PGC-1α−/− and PGC-1α+/+ mice were subjected to a run-to-exhaustion protocol on a motorized treadmill (left graph) as described in Materials and Methods. * p < 0.001 compared to corresponding PGC-1α+/+ values. VO2max measurements were determined for 2-mo-old male mice for each genotype using a motorized treadmill at an elevation of 150 m and indirect calorimetry set-up (right graph) as described in Materials and Methods. * p < 0.05 compared to corresponding PGC-1α+/+ values. (C) Time course of fatigue following repeated stimulation of soleus muscle is shown for 4-mo-old male PGC-1α−/− (n = 5) and PGC-1α+/+ (n = 5) mice (left graph). The mean percent force remaining at 2 min (Fatigue Resistance Index) is shown (right graph). * p < 0.05 compared to corresponding PGC-1α+/+ values. A battery of tests was performed to further evaluate the general sensorimotor phenotype of the PGC-1α−/− mice.
T12734	20833-20834	DT	denotes	A
T12735	20835-20842	NN	denotes	battery
T12736	20856-20865	VBN	denotes	performed
T12737	20843-20845	IN	denotes	of
T12738	20846-20851	NNS	denotes	tests
T12739	20852-20855	VBD	denotes	was
T12740	20866-20868	TO	denotes	to
T12741	20877-20885	VB	denotes	evaluate
T12742	20869-20876	RB	denotes	further
T12743	20886-20889	DT	denotes	the
T12744	20911-20920	NN	denotes	phenotype
T12745	20890-20897	JJ	denotes	general
T12746	20898-20910	NN	denotes	sensorimotor
T12747	20921-20923	IN	denotes	of
T12748	20924-20927	DT	denotes	the
T12749	20938-20942	NNS	denotes	mice
T12750	20928-20931	NN	denotes	PGC
T12751	20932-20934	NN	denotes	1α
T12752	20931-20932	HYPH	denotes	-
T12753	20934-20935	SYM	denotes	−
T12754	20935-20936	HYPH	denotes	/
T12755	20936-20937	SYM	denotes	−
T12756	20942-20943	.	denotes	.
T12757	20943-21199	sentence	denotes	No differences were found between PGC-1α−/− mice and PGC-1α+/+ controls on the ledge, platform, walking initiation, and 60° and 90° inclined screen tests (unpublished data), suggesting that several sensorimotor functions were intact in the PGC-1α−/− mice.
T12758	20944-20946	DT	denotes	No
T12759	20947-20958	NNS	denotes	differences
T12760	20964-20969	VBN	denotes	found
T12761	20959-20963	VBD	denotes	were
T12762	20970-20977	IN	denotes	between
T12763	20978-20981	NN	denotes	PGC
T12764	20982-20984	NN	denotes	1α
T12765	20981-20982	HYPH	denotes	-
T12766	20988-20992	NNS	denotes	mice
T12767	20984-20985	SYM	denotes	−
T12768	20985-20986	HYPH	denotes	/
T12769	20986-20987	SYM	denotes	−
T12770	20993-20996	CC	denotes	and
T12771	20997-21000	NN	denotes	PGC
T12772	21001-21003	NN	denotes	1α
T12773	21000-21001	HYPH	denotes	-
T12774	21007-21015	NNS	denotes	controls
T12775	21003-21004	SYM	denotes	+
T12776	21004-21005	HYPH	denotes	/
T12777	21005-21006	SYM	denotes	+
T12778	21016-21018	IN	denotes	on
T12779	21019-21022	DT	denotes	the
T12780	21092-21097	NNS	denotes	tests
T12781	21023-21028	NN	denotes	ledge
T12782	21028-21030	,	denotes	,
T12783	21030-21038	NN	denotes	platform
T12784	21038-21040	,	denotes	,
T12785	21040-21047	NN	denotes	walking
T12786	21048-21058	NN	denotes	initiation
T12787	21058-21060	,	denotes	,
T12788	21060-21063	CC	denotes	and
T12789	21064-21066	CD	denotes	60
T12790	21066-21067	NN	denotes	°
T12791	21085-21091	NN	denotes	screen
T12792	21068-21071	CC	denotes	and
T12793	21072-21074	CD	denotes	90
T12794	21074-21075	NN	denotes	°
T12795	21076-21084	VBN	denotes	inclined
T12796	21098-21099	-LRB-	denotes	(
T12797	21111-21115	NNS	denotes	data
T12798	21099-21110	JJ	denotes	unpublished
T12799	21115-21116	-RRB-	denotes	)
T12800	21116-21118	,	denotes	,
T12801	21118-21128	VBG	denotes	suggesting
T12802	21129-21133	IN	denotes	that
T12803	21165-21169	VBD	denotes	were
T12804	21134-21141	JJ	denotes	several
T12805	21155-21164	NNS	denotes	functions
T12806	21142-21154	NN	denotes	sensorimotor
T12807	21170-21176	JJ	denotes	intact
T12808	21177-21179	IN	denotes	in
T12809	21180-21183	DT	denotes	the
T12810	21194-21198	NNS	denotes	mice
T12811	21184-21187	NN	denotes	PGC
T12812	21188-21190	NN	denotes	1α
T12813	21187-21188	HYPH	denotes	-
T12814	21190-21191	SYM	denotes	−
T12815	21191-21192	HYPH	denotes	/
T12816	21192-21193	SYM	denotes	−
T12817	21198-21199	.	denotes	.
T12818	21199-21322	sentence	denotes	However, the PGC-1α−/− mice were unable to remain on an inverted screen for as long as the PGC-1α+/+ controls (Figure 4A).
T12819	21200-21207	RB	denotes	However
T12820	21228-21232	VBD	denotes	were
T12821	21207-21209	,	denotes	,
T12822	21209-21212	DT	denotes	the
T12823	21223-21227	NNS	denotes	mice
T12824	21213-21216	NN	denotes	PGC
T12825	21217-21219	NN	denotes	1α
T12826	21216-21217	HYPH	denotes	-
T12827	21219-21220	SYM	denotes	−
T12828	21220-21221	HYPH	denotes	/
T12829	21221-21222	SYM	denotes	−
T12830	21233-21239	JJ	denotes	unable
T12831	21240-21242	TO	denotes	to
T12832	21243-21249	VB	denotes	remain
T12833	21250-21252	IN	denotes	on
T12834	21253-21255	DT	denotes	an
T12835	21265-21271	NN	denotes	screen
T12836	21256-21264	VBN	denotes	inverted
T12837	21272-21275	IN	denotes	for
T12838	21276-21278	RB	denotes	as
T12839	21279-21283	RB	denotes	long
T12840	21284-21286	IN	denotes	as
T12841	21287-21290	DT	denotes	the
T12842	21301-21309	NNS	denotes	controls
T12843	21291-21294	NN	denotes	PGC
T12844	21295-21297	NN	denotes	1α
T12845	21294-21295	HYPH	denotes	-
T12846	21297-21298	SYM	denotes	+
T12847	21298-21299	HYPH	denotes	/
T12848	21299-21300	SYM	denotes	+
T12849	21310-21311	-LRB-	denotes	(
T12850	21318-21320	NN	denotes	4A
T12851	21311-21317	NN	denotes	Figure
T12852	21320-21321	-RRB-	denotes	)
T12853	21321-21322	.	denotes	.
T12854	21322-21596	sentence	denotes	Since the groups did not differ on the times it took to turn around and climb to the top of 60° and 90° inclined screens, the differences on the inverted screen test suggest that impaired strength rather than deficits in coordination were responsible for these differences.
T12855	21323-21328	IN	denotes	Since
T12856	21348-21354	VB	denotes	differ
T12857	21329-21332	DT	denotes	the
T12858	21333-21339	NNS	denotes	groups
T12859	21340-21343	VBD	denotes	did
T12860	21344-21347	RB	denotes	not
T12861	21489-21496	VBP	denotes	suggest
T12862	21355-21357	IN	denotes	on
T12863	21358-21361	DT	denotes	the
T12864	21362-21367	NNS	denotes	times
T12865	21368-21370	PRP	denotes	it
T12866	21371-21375	VBD	denotes	took
T12867	21376-21378	TO	denotes	to
T12868	21379-21383	VB	denotes	turn
T12869	21384-21390	RB	denotes	around
T12870	21391-21394	CC	denotes	and
T12871	21395-21400	VB	denotes	climb
T12872	21401-21403	IN	denotes	to
T12873	21404-21407	DT	denotes	the
T12874	21408-21411	NN	denotes	top
T12875	21412-21414	IN	denotes	of
T12876	21415-21417	CD	denotes	60
T12877	21417-21418	NN	denotes	°
T12878	21436-21443	NNS	denotes	screens
T12879	21419-21422	CC	denotes	and
T12880	21423-21425	CD	denotes	90
T12881	21425-21426	NN	denotes	°
T12882	21427-21435	VBN	denotes	inclined
T12883	21443-21445	,	denotes	,
T12884	21445-21448	DT	denotes	the
T12885	21449-21460	NNS	denotes	differences
T12886	21461-21463	IN	denotes	on
T12887	21464-21467	DT	denotes	the
T12888	21484-21488	NN	denotes	test
T12889	21468-21476	VBN	denotes	inverted
T12890	21477-21483	NN	denotes	screen
T12891	21497-21501	IN	denotes	that
T12892	21557-21561	VBD	denotes	were
T12893	21502-21510	JJ	denotes	impaired
T12894	21511-21519	NN	denotes	strength
T12895	21520-21526	RB	denotes	rather
T12896	21527-21531	IN	denotes	than
T12897	21532-21540	NNS	denotes	deficits
T12898	21541-21543	IN	denotes	in
T12899	21544-21556	NN	denotes	coordination
T12900	21562-21573	JJ	denotes	responsible
T12901	21574-21577	IN	denotes	for
T12902	21578-21583	DT	denotes	these
T12903	21584-21595	NNS	denotes	differences
T12904	21595-21596	.	denotes	.
T12905	21596-21701	sentence	denotes	To further evaluate the skeletal muscle phenotype, exercise capacity was assessed in the PGC-1α−/− mice.
T12906	21597-21599	TO	denotes	To
T12907	21608-21616	VB	denotes	evaluate
T12908	21600-21607	RB	denotes	further
T12909	21670-21678	VBN	denotes	assessed
T12910	21617-21620	DT	denotes	the
T12911	21637-21646	NN	denotes	phenotype
T12912	21621-21629	JJ	denotes	skeletal
T12913	21630-21636	NN	denotes	muscle
T12914	21646-21648	,	denotes	,
T12915	21648-21656	NN	denotes	exercise
T12916	21657-21665	NN	denotes	capacity
T12917	21666-21669	VBD	denotes	was
T12918	21679-21681	IN	denotes	in
T12919	21682-21685	DT	denotes	the
T12920	21696-21700	NNS	denotes	mice
T12921	21686-21689	NN	denotes	PGC
T12922	21690-21692	NN	denotes	1α
T12923	21689-21690	HYPH	denotes	-
T12924	21692-21693	SYM	denotes	−
T12925	21693-21694	HYPH	denotes	/
T12926	21694-21695	SYM	denotes	−
T12927	21700-21701	.	denotes	.
T12928	21701-21817	sentence	denotes	To this end, the PGC-1α−/− mice were exercised on a motorized treadmill apparatus using a run-to-exhaustion format.
T12929	21702-21704	IN	denotes	To
T12930	21739-21748	VBN	denotes	exercised
T12931	21705-21709	DT	denotes	this
T12932	21710-21713	NN	denotes	end
T12933	21713-21715	,	denotes	,
T12934	21715-21718	DT	denotes	the
T12935	21729-21733	NNS	denotes	mice
T12936	21719-21722	NN	denotes	PGC
T12937	21723-21725	NN	denotes	1α
T12938	21722-21723	HYPH	denotes	-
T12939	21725-21726	SYM	denotes	−
T12940	21726-21727	HYPH	denotes	/
T12941	21727-21728	SYM	denotes	−
T12942	21734-21738	VBD	denotes	were
T12943	21749-21751	IN	denotes	on
T12944	21752-21753	DT	denotes	a
T12945	21774-21783	NN	denotes	apparatus
T12946	21754-21763	VBN	denotes	motorized
T12947	21764-21773	NN	denotes	treadmill
T12948	21784-21789	VBG	denotes	using
T12949	21790-21791	DT	denotes	a
T12950	21810-21816	NN	denotes	format
T12951	21792-21795	VB	denotes	run
T12952	21795-21796	HYPH	denotes	-
T12953	21796-21798	IN	denotes	to
T12954	21798-21799	HYPH	denotes	-
T12955	21799-21809	NN	denotes	exhaustion
T12956	21816-21817	.	denotes	.
T12957	21817-21994	sentence	denotes	PGC-1α−/− mice (6–8 mo of age) exhibited a markedly reduced capacity to sustain running exercise (PGC-1α−/− mice, 64 ± 6 s; age-matched PGC-1α+/+ mice, 586 ± 104 s; Figure 4B).
T12958	21818-21821	NN	denotes	PGC
T12959	21822-21824	NN	denotes	1α
T12960	21821-21822	HYPH	denotes	-
T12961	21828-21832	NNS	denotes	mice
T12962	21824-21825	SYM	denotes	−
T12963	21825-21826	HYPH	denotes	/
T12964	21826-21827	SYM	denotes	−
T12965	21849-21858	VBD	denotes	exhibited
T12966	21833-21834	-LRB-	denotes	(
T12967	21834-21835	CD	denotes	6
T12968	21836-21837	CD	denotes	8
T12969	21835-21836	SYM	denotes	–
T12970	21838-21840	NN	denotes	mo
T12971	21841-21843	IN	denotes	of
T12972	21844-21847	NN	denotes	age
T12973	21847-21848	-RRB-	denotes	)
T12974	21859-21860	DT	denotes	a
T12975	21878-21886	NN	denotes	capacity
T12976	21861-21869	RB	denotes	markedly
T12977	21870-21877	JJ	denotes	reduced
T12978	21887-21889	TO	denotes	to
T12979	21890-21897	VB	denotes	sustain
T12980	21898-21905	NN	denotes	running
T12981	21906-21914	NN	denotes	exercise
T12982	21915-21916	-LRB-	denotes	(
T12983	21990-21992	NN	denotes	4B
T12984	21916-21919	NN	denotes	PGC
T12985	21920-21922	NN	denotes	1α
T12986	21919-21920	HYPH	denotes	-
T12987	21926-21930	NNS	denotes	mice
T12988	21922-21923	SYM	denotes	−
T12989	21923-21924	HYPH	denotes	/
T12990	21924-21925	SYM	denotes	−
T12991	21939-21940	NN	denotes	s
T12992	21930-21932	,	denotes	,
T12993	21932-21934	CD	denotes	64
T12994	21937-21938	CD	denotes	6
T12995	21935-21936	SYM	denotes	±
T12996	21940-21941	:	denotes	;
T12997	21942-21945	NN	denotes	age
T12998	21946-21953	VBN	denotes	matched
T12999	21945-21946	HYPH	denotes	-
T13000	21964-21968	NNS	denotes	mice
T13001	21954-21957	NN	denotes	PGC
T13002	21958-21960	NN	denotes	1α
T13003	21957-21958	HYPH	denotes	-
T13004	21960-21961	SYM	denotes	+
T13005	21961-21962	HYPH	denotes	/
T13006	21962-21963	SYM	denotes	+
T13007	21980-21981	NN	denotes	s
T13008	21968-21970	,	denotes	,
T13009	21970-21973	CD	denotes	586
T13010	21976-21979	CD	denotes	104
T13011	21974-21975	SYM	denotes	±
T13012	21981-21982	:	denotes	;
T13013	21983-21989	NN	denotes	Figure
T13014	21992-21993	-RRB-	denotes	)
T13015	21993-21994	.	denotes	.
T13016	21994-22095	sentence	denotes	The same result was obtained with younger PGC-1α−/− mice, i.e., at 3.5 mo of age (unpublished data).
T13017	21995-21998	DT	denotes	The
T13018	22004-22010	NN	denotes	result
T13019	21999-22003	JJ	denotes	same
T13020	22015-22023	VBN	denotes	obtained
T13021	22011-22014	VBD	denotes	was
T13022	22024-22028	IN	denotes	with
T13023	22029-22036	JJR	denotes	younger
T13024	22047-22051	NNS	denotes	mice
T13025	22037-22040	NN	denotes	PGC
T13026	22041-22043	NN	denotes	1α
T13027	22040-22041	HYPH	denotes	-
T13028	22043-22044	SYM	denotes	−
T13029	22044-22045	HYPH	denotes	/
T13030	22045-22046	SYM	denotes	−
T13031	22051-22053	,	denotes	,
T13032	22053-22057	FW	denotes	i.e.
T13033	22059-22061	IN	denotes	at
T13034	22057-22059	,	denotes	,
T13035	22062-22065	CD	denotes	3.5
T13036	22066-22068	NN	denotes	mo
T13037	22069-22071	IN	denotes	of
T13038	22072-22075	NN	denotes	age
T13039	22076-22077	-LRB-	denotes	(
T13040	22089-22093	NNS	denotes	data
T13041	22077-22088	JJ	denotes	unpublished
T13042	22093-22094	-RRB-	denotes	)
T13043	22094-22095	.	denotes	.
T13044	22095-22321	sentence	denotes	To quantify aerobic exercise capacity, VO2max (maximum oxygen consumption, measured in milliliters of oxygen per kilogram of body weight per minute) was measured with the treadmill-running protocol using indirect calorimetry.
T13045	22096-22098	TO	denotes	To
T13046	22099-22107	VB	denotes	quantify
T13047	22249-22257	VBN	denotes	measured
T13048	22108-22115	JJ	denotes	aerobic
T13049	22125-22133	NN	denotes	capacity
T13050	22116-22124	NN	denotes	exercise
T13051	22133-22135	,	denotes	,
T13052	22135-22141	NN	denotes	VO2max
T13053	22142-22143	-LRB-	denotes	(
T13054	22143-22150	NN	denotes	maximum
T13055	22158-22169	NN	denotes	consumption
T13056	22151-22157	NN	denotes	oxygen
T13057	22169-22171	,	denotes	,
T13058	22171-22179	VBN	denotes	measured
T13059	22180-22182	IN	denotes	in
T13060	22183-22194	NNS	denotes	milliliters
T13061	22195-22197	IN	denotes	of
T13062	22198-22204	NN	denotes	oxygen
T13063	22205-22208	IN	denotes	per
T13064	22209-22217	NN	denotes	kilogram
T13065	22218-22220	IN	denotes	of
T13066	22221-22225	NN	denotes	body
T13067	22226-22232	NN	denotes	weight
T13068	22233-22236	IN	denotes	per
T13069	22237-22243	NN	denotes	minute
T13070	22243-22244	-RRB-	denotes	)
T13071	22245-22248	VBD	denotes	was
T13072	22258-22262	IN	denotes	with
T13073	22263-22266	DT	denotes	the
T13074	22285-22293	NN	denotes	protocol
T13075	22267-22276	NN	denotes	treadmill
T13076	22276-22277	HYPH	denotes	-
T13077	22277-22284	VBG	denotes	running
T13078	22294-22299	VBG	denotes	using
T13079	22300-22308	JJ	denotes	indirect
T13080	22309-22320	NN	denotes	calorimetry
T13081	22320-22321	.	denotes	.
T13082	22321-22489	sentence	denotes	VO2max was significantly lower for the PGC-1α−/− mice (120.9 ± 2.0 ml O2 · kg−1 · min−1) compared to PGC-1α+/+ controls (141.6 ± 2.1 ml O2 · kg−1 · min−1) (Figure 4B).
T13083	22322-22328	NN	denotes	VO2max
T13084	22329-22332	VBD	denotes	was
T13085	22333-22346	RB	denotes	significantly
T13086	22347-22352	JJR	denotes	lower
T13087	22353-22356	IN	denotes	for
T13088	22357-22360	DT	denotes	the
T13089	22371-22375	NNS	denotes	mice
T13090	22361-22364	NN	denotes	PGC
T13091	22365-22367	NN	denotes	1α
T13092	22364-22365	HYPH	denotes	-
T13093	22367-22368	SYM	denotes	−
T13094	22368-22369	HYPH	denotes	/
T13095	22369-22370	SYM	denotes	−
T13096	22376-22377	-LRB-	denotes	(
T13097	22392-22394	NN	denotes	O2
T13098	22377-22382	CD	denotes	120.9
T13099	22385-22388	CD	denotes	2.0
T13100	22383-22384	SYM	denotes	±
T13101	22389-22391	NN	denotes	ml
T13102	22395-22396	SYM	denotes	·
T13103	22397-22399	NN	denotes	kg
T13104	22399-22400	SYM	denotes	−
T13105	22400-22401	CD	denotes	1
T13106	22402-22403	SYM	denotes	·
T13107	22404-22407	NN	denotes	min
T13108	22407-22408	SYM	denotes	−
T13109	22408-22409	CD	denotes	1
T13110	22409-22410	-RRB-	denotes	)
T13111	22411-22419	VBN	denotes	compared
T13112	22420-22422	IN	denotes	to
T13113	22423-22426	NN	denotes	PGC
T13114	22427-22429	NN	denotes	1α
T13115	22426-22427	HYPH	denotes	-
T13116	22433-22441	NNS	denotes	controls
T13117	22429-22430	SYM	denotes	+
T13118	22430-22431	HYPH	denotes	/
T13119	22431-22432	SYM	denotes	+
T13120	22442-22443	-LRB-	denotes	(
T13121	22458-22460	NN	denotes	O2
T13122	22443-22448	CD	denotes	141.6
T13123	22451-22454	CD	denotes	2.1
T13124	22449-22450	SYM	denotes	±
T13125	22455-22457	NN	denotes	ml
T13126	22461-22462	SYM	denotes	·
T13127	22463-22465	NN	denotes	kg
T13128	22465-22466	SYM	denotes	−
T13129	22466-22467	CD	denotes	1
T13130	22468-22469	SYM	denotes	·
T13131	22470-22473	NN	denotes	min
T13132	22473-22474	SYM	denotes	−
T13133	22474-22475	CD	denotes	1
T13134	22475-22476	-RRB-	denotes	)
T13135	22477-22478	-LRB-	denotes	(
T13136	22485-22487	NN	denotes	4B
T13137	22478-22484	NN	denotes	Figure
T13138	22487-22488	-RRB-	denotes	)
T13139	22488-22489	.	denotes	.
T13140	22489-22618	sentence	denotes	To directly evaluate muscle fatigability, the force response to repetitive stimulation of isolated soleus muscle was determined.
T13141	22490-22492	TO	denotes	To
T13142	22502-22510	VB	denotes	evaluate
T13143	22493-22501	RB	denotes	directly
T13144	22607-22617	VBN	denotes	determined
T13145	22511-22517	NN	denotes	muscle
T13146	22518-22530	NN	denotes	fatigability
T13147	22530-22532	,	denotes	,
T13148	22532-22535	DT	denotes	the
T13149	22542-22550	NN	denotes	response
T13150	22536-22541	NN	denotes	force
T13151	22551-22553	IN	denotes	to
T13152	22554-22564	JJ	denotes	repetitive
T13153	22565-22576	NN	denotes	stimulation
T13154	22577-22579	IN	denotes	of
T13155	22580-22588	VBN	denotes	isolated
T13156	22596-22602	NN	denotes	muscle
T13157	22589-22595	NN	denotes	soleus
T13158	22603-22606	VBD	denotes	was
T13159	22617-22618	.	denotes	.
T13160	22618-22726	sentence	denotes	The capacity to generate force following a series of tetani is dependent upon mitochondrial ATP production.
T13161	22619-22622	DT	denotes	The
T13162	22623-22631	NN	denotes	capacity
T13163	22679-22681	VBZ	denotes	is
T13164	22632-22634	TO	denotes	to
T13165	22635-22643	VB	denotes	generate
T13166	22644-22649	NN	denotes	force
T13167	22650-22659	VBG	denotes	following
T13168	22660-22661	DT	denotes	a
T13169	22662-22668	NN	denotes	series
T13170	22669-22671	IN	denotes	of
T13171	22672-22678	NNS	denotes	tetani
T13172	22682-22691	JJ	denotes	dependent
T13173	22692-22696	IN	denotes	upon
T13174	22697-22710	JJ	denotes	mitochondrial
T13175	22715-22725	NN	denotes	production
T13176	22711-22714	NN	denotes	ATP
T13177	22725-22726	.	denotes	.
T13178	22726-22886	sentence	denotes	During the initial phase of the stimulation period, there was no difference in force generation in muscles isolated from PGC-1α−/− mice and PGC-1α+/+ controls.
T13179	22727-22733	IN	denotes	During
T13180	22785-22788	VBD	denotes	was
T13181	22734-22737	DT	denotes	the
T13182	22746-22751	NN	denotes	phase
T13183	22738-22745	JJ	denotes	initial
T13184	22752-22754	IN	denotes	of
T13185	22755-22758	DT	denotes	the
T13186	22771-22777	NN	denotes	period
T13187	22759-22770	NN	denotes	stimulation
T13188	22777-22779	,	denotes	,
T13189	22779-22784	EX	denotes	there
T13190	22789-22791	DT	denotes	no
T13191	22792-22802	NN	denotes	difference
T13192	22803-22805	IN	denotes	in
T13193	22806-22811	NN	denotes	force
T13194	22812-22822	NN	denotes	generation
T13195	22823-22825	IN	denotes	in
T13196	22826-22833	NNS	denotes	muscles
T13197	22834-22842	VBN	denotes	isolated
T13198	22843-22847	IN	denotes	from
T13199	22848-22851	NN	denotes	PGC
T13200	22852-22854	NN	denotes	1α
T13201	22851-22852	HYPH	denotes	-
T13202	22858-22862	NNS	denotes	mice
T13203	22854-22855	SYM	denotes	−
T13204	22855-22856	HYPH	denotes	/
T13205	22856-22857	SYM	denotes	−
T13206	22863-22866	CC	denotes	and
T13207	22867-22870	NN	denotes	PGC
T13208	22871-22873	NN	denotes	1α
T13209	22870-22871	HYPH	denotes	-
T13210	22877-22885	NNS	denotes	controls
T13211	22873-22874	SYM	denotes	+
T13212	22874-22875	HYPH	denotes	/
T13213	22875-22876	SYM	denotes	+
T13214	22885-22886	.	denotes	.
T13215	22886-23141	sentence	denotes	However, fatigue resistance index, defined as the percent of initial force generated following a 2-min series of fatiguing contractions, was significantly lower in the PGC-1α−/− mice (14.6 ± 1.5%) compared to PGC-1α+/+ controls (24.8 ± 2.9%) (Figure 4C).
T13216	22887-22894	RB	denotes	However
T13217	23024-23027	VBD	denotes	was
T13218	22894-22896	,	denotes	,
T13219	22896-22903	NN	denotes	fatigue
T13220	22904-22914	NN	denotes	resistance
T13221	22915-22920	NN	denotes	index
T13222	22920-22922	,	denotes	,
T13223	22922-22929	VBN	denotes	defined
T13224	22930-22932	IN	denotes	as
T13225	22933-22936	DT	denotes	the
T13226	22937-22944	NN	denotes	percent
T13227	22945-22947	IN	denotes	of
T13228	22948-22955	JJ	denotes	initial
T13229	22956-22961	NN	denotes	force
T13230	22962-22971	VBN	denotes	generated
T13231	22972-22981	VBG	denotes	following
T13232	22982-22983	DT	denotes	a
T13233	22990-22996	NN	denotes	series
T13234	22984-22985	CD	denotes	2
T13235	22986-22989	NN	denotes	min
T13236	22985-22986	HYPH	denotes	-
T13237	22997-22999	IN	denotes	of
T13238	23000-23009	VBG	denotes	fatiguing
T13239	23010-23022	NNS	denotes	contractions
T13240	23022-23024	,	denotes	,
T13241	23028-23041	RB	denotes	significantly
T13242	23042-23047	JJR	denotes	lower
T13243	23048-23050	IN	denotes	in
T13244	23051-23054	DT	denotes	the
T13245	23065-23069	NNS	denotes	mice
T13246	23055-23058	NN	denotes	PGC
T13247	23059-23061	NN	denotes	1α
T13248	23058-23059	HYPH	denotes	-
T13249	23061-23062	SYM	denotes	−
T13250	23062-23063	HYPH	denotes	/
T13251	23063-23064	SYM	denotes	−
T13252	23070-23071	-LRB-	denotes	(
T13253	23081-23082	NN	denotes	%
T13254	23071-23075	CD	denotes	14.6
T13255	23078-23081	CD	denotes	1.5
T13256	23076-23077	SYM	denotes	±
T13257	23082-23083	-RRB-	denotes	)
T13258	23084-23092	VBN	denotes	compared
T13259	23093-23095	IN	denotes	to
T13260	23096-23099	NN	denotes	PGC
T13261	23100-23102	NN	denotes	1α
T13262	23099-23100	HYPH	denotes	-
T13263	23106-23114	NNS	denotes	controls
T13264	23102-23103	SYM	denotes	+
T13265	23103-23104	HYPH	denotes	/
T13266	23104-23105	SYM	denotes	+
T13267	23115-23116	-LRB-	denotes	(
T13268	23126-23127	NN	denotes	%
T13269	23116-23120	CD	denotes	24.8
T13270	23123-23126	CD	denotes	2.9
T13271	23121-23122	SYM	denotes	±
T13272	23127-23128	-RRB-	denotes	)
T13273	23129-23130	-LRB-	denotes	(
T13274	23137-23139	NN	denotes	4C
T13275	23130-23136	NN	denotes	Figure
T13276	23139-23140	-RRB-	denotes	)
T13277	23140-23141	.	denotes	.
T13278	23141-23357	sentence	denotes	These results, together with the observed abnormalities in skeletal muscle mitochondrial structure and function, indicate that PGC-1α is necessary for functional adaptation of skeletal muscle to physiologic demands.
T13279	23142-23147	DT	denotes	These
T13280	23148-23155	NNS	denotes	results
T13281	23255-23263	VBP	denotes	indicate
T13282	23155-23157	,	denotes	,
T13283	23157-23165	RB	denotes	together
T13284	23166-23170	IN	denotes	with
T13285	23171-23174	DT	denotes	the
T13286	23184-23197	NNS	denotes	abnormalities
T13287	23175-23183	VBN	denotes	observed
T13288	23198-23200	IN	denotes	in
T13289	23201-23209	JJ	denotes	skeletal
T13290	23231-23240	NN	denotes	structure
T13291	23210-23216	NN	denotes	muscle
T13292	23217-23230	JJ	denotes	mitochondrial
T13293	23241-23244	CC	denotes	and
T13294	23245-23253	NN	denotes	function
T13295	23253-23255	,	denotes	,
T13296	23264-23268	IN	denotes	that
T13297	23276-23278	VBZ	denotes	is
T13298	23269-23272	NN	denotes	PGC
T13299	23273-23275	NN	denotes	1α
T13300	23272-23273	HYPH	denotes	-
T13301	23279-23288	JJ	denotes	necessary
T13302	23289-23292	IN	denotes	for
T13303	23293-23303	JJ	denotes	functional
T13304	23304-23314	NN	denotes	adaptation
T13305	23315-23317	IN	denotes	of
T13306	23318-23326	JJ	denotes	skeletal
T13307	23327-23333	NN	denotes	muscle
T13308	23334-23336	IN	denotes	to
T13309	23337-23348	JJ	denotes	physiologic
T13310	23349-23356	NNS	denotes	demands
T13311	23356-23357	.	denotes	.
T15167	23359-23369	JJ	denotes	Functional
T15168	23370-23383	NNS	denotes	Abnormalities
T15169	23384-23386	IN	denotes	in
T15170	23387-23393	NNS	denotes	Hearts
T15171	23394-23396	IN	denotes	of
T15172	23397-23400	NN	denotes	PGC
T15173	23401-23403	NN	denotes	1α
T15174	23400-23401	HYPH	denotes	-
T15175	23407-23411	NNS	denotes	Mice
T15176	23403-23404	SYM	denotes	−
T15177	23404-23405	HYPH	denotes	/
T15178	23405-23406	SYM	denotes	−
T15179	23411-23598	sentence	denotes	PGC-1α expression is enriched in heart, a tissue that relies heavily on mitochondrial energy metabolism to maintain pump function throughout the postnatal life of the mammalian organism.
T15180	23412-23415	NN	denotes	PGC
T15181	23416-23418	NN	denotes	1α
T15182	23415-23416	HYPH	denotes	-
T15183	23419-23429	NN	denotes	expression
T15184	23433-23441	VBN	denotes	enriched
T15185	23430-23432	VBZ	denotes	is
T15186	23442-23444	IN	denotes	in
T15187	23445-23450	NN	denotes	heart
T15188	23450-23452	,	denotes	,
T15189	23452-23453	DT	denotes	a
T15190	23454-23460	NN	denotes	tissue
T15191	23461-23465	WDT	denotes	that
T15192	23466-23472	VBZ	denotes	relies
T15193	23473-23480	RB	denotes	heavily
T15194	23481-23483	IN	denotes	on
T15195	23484-23497	JJ	denotes	mitochondrial
T15196	23505-23515	NN	denotes	metabolism
T15197	23498-23504	NN	denotes	energy
T15198	23516-23518	TO	denotes	to
T15199	23519-23527	VB	denotes	maintain
T15200	23528-23532	NN	denotes	pump
T15201	23533-23541	NN	denotes	function
T15202	23542-23552	IN	denotes	throughout
T15203	23553-23556	DT	denotes	the
T15204	23567-23571	NN	denotes	life
T15205	23557-23566	JJ	denotes	postnatal
T15206	23572-23574	IN	denotes	of
T15207	23575-23578	DT	denotes	the
T15208	23589-23597	NN	denotes	organism
T15209	23579-23588	JJ	denotes	mammalian
T15210	23597-23598	.	denotes	.
T15211	23598-23795	sentence	denotes	Echocardiographic screening studies of PGC-1α−/− mice at ages 4–6 mo did not reveal any significant differences in chamber sizes or ventricular function compared to WT controls (unpublished data).
T15212	23599-23616	JJ	denotes	Echocardiographic
T15213	23627-23634	NNS	denotes	studies
T15214	23617-23626	NN	denotes	screening
T15215	23676-23682	VB	denotes	reveal
T15216	23635-23637	IN	denotes	of
T15217	23638-23641	NN	denotes	PGC
T15218	23642-23644	NN	denotes	1α
T15219	23641-23642	HYPH	denotes	-
T15220	23648-23652	NNS	denotes	mice
T15221	23644-23645	SYM	denotes	−
T15222	23645-23646	HYPH	denotes	/
T15223	23646-23647	SYM	denotes	−
T15224	23653-23655	IN	denotes	at
T15225	23656-23660	NNS	denotes	ages
T15226	23665-23667	NN	denotes	mo
T15227	23661-23662	CD	denotes	4
T15228	23663-23664	CD	denotes	6
T15229	23662-23663	SYM	denotes	–
T15230	23668-23671	VBD	denotes	did
T15231	23672-23675	RB	denotes	not
T15232	23683-23686	DT	denotes	any
T15233	23699-23710	NNS	denotes	differences
T15234	23687-23698	JJ	denotes	significant
T15235	23711-23713	IN	denotes	in
T15236	23714-23721	NN	denotes	chamber
T15237	23722-23727	NNS	denotes	sizes
T15238	23728-23730	CC	denotes	or
T15239	23731-23742	JJ	denotes	ventricular
T15240	23743-23751	NN	denotes	function
T15241	23752-23760	VBN	denotes	compared
T15242	23761-23763	IN	denotes	to
T15243	23764-23766	NN	denotes	WT
T15244	23767-23775	NNS	denotes	controls
T15245	23776-23777	-LRB-	denotes	(
T15246	23789-23793	NNS	denotes	data
T15247	23777-23788	JJ	denotes	unpublished
T15248	23793-23794	-RRB-	denotes	)
T15249	23794-23795	.	denotes	.
T15250	23795-23905	sentence	denotes	Cardiac functional and metabolic reserve was evaluated using exercise echocardiographic stress testing (EST).
T15251	23796-23803	JJ	denotes	Cardiac
T15252	23804-23814	JJ	denotes	functional
T15253	23829-23836	NN	denotes	reserve
T15254	23815-23818	CC	denotes	and
T15255	23819-23828	JJ	denotes	metabolic
T15256	23841-23850	VBN	denotes	evaluated
T15257	23837-23840	VBD	denotes	was
T15258	23851-23856	VBG	denotes	using
T15259	23857-23865	NN	denotes	exercise
T15260	23891-23898	NN	denotes	testing
T15261	23866-23883	JJ	denotes	echocardiographic
T15262	23884-23890	NN	denotes	stress
T15263	23899-23900	-LRB-	denotes	(
T15264	23900-23903	NN	denotes	EST
T15265	23903-23904	-RRB-	denotes	)
T15266	23904-23905	.	denotes	.
T15267	23905-24145	sentence	denotes	Given that the exercise capacity of PGC-1α−/− mice is diminished, a series of preliminary treadmill exercise studies were performed to define a reasonable exercise duration for run-to-exhaustion to be used as a target duration for the EST.
T15268	23906-23911	VBN	denotes	Given
T15269	24028-24037	VBN	denotes	performed
T15270	23912-23916	IN	denotes	that
T15271	23960-23970	VBN	denotes	diminished
T15272	23917-23920	DT	denotes	the
T15273	23930-23938	NN	denotes	capacity
T15274	23921-23929	NN	denotes	exercise
T15275	23939-23941	IN	denotes	of
T15276	23942-23945	NN	denotes	PGC
T15277	23946-23948	NN	denotes	1α
T15278	23945-23946	HYPH	denotes	-
T15279	23952-23956	NNS	denotes	mice
T15280	23948-23949	SYM	denotes	−
T15281	23949-23950	HYPH	denotes	/
T15282	23950-23951	SYM	denotes	−
T15283	23957-23959	VBZ	denotes	is
T15284	23970-23972	,	denotes	,
T15285	23972-23973	DT	denotes	a
T15286	23974-23980	NN	denotes	series
T15287	23981-23983	IN	denotes	of
T15288	23984-23995	JJ	denotes	preliminary
T15289	24015-24022	NNS	denotes	studies
T15290	23996-24005	NN	denotes	treadmill
T15291	24006-24014	NN	denotes	exercise
T15292	24023-24027	VBD	denotes	were
T15293	24038-24040	TO	denotes	to
T15294	24041-24047	VB	denotes	define
T15295	24048-24049	DT	denotes	a
T15296	24070-24078	NN	denotes	duration
T15297	24050-24060	JJ	denotes	reasonable
T15298	24061-24069	NN	denotes	exercise
T15299	24079-24082	IN	denotes	for
T15300	24083-24086	VB	denotes	run
T15301	24107-24111	VBN	denotes	used
T15302	24086-24087	HYPH	denotes	-
T15303	24087-24089	IN	denotes	to
T15304	24089-24090	HYPH	denotes	-
T15305	24090-24100	NN	denotes	exhaustion
T15306	24101-24103	TO	denotes	to
T15307	24104-24106	VB	denotes	be
T15308	24112-24114	IN	denotes	as
T15309	24115-24116	DT	denotes	a
T15310	24124-24132	NN	denotes	duration
T15311	24117-24123	NN	denotes	target
T15312	24133-24136	IN	denotes	for
T15313	24137-24140	DT	denotes	the
T15314	24141-24144	NN	denotes	EST
T15315	24144-24145	.	denotes	.
T15316	24145-24355	sentence	denotes	Based on the results of these studies, an EST regimen was performed in which PGC-1α+/+ control animals were exercised for a duration of 60 s to match the predicted average for the PGC-1α−/− mice (ages 6–8 mo).
T15317	24146-24151	VBN	denotes	Based
T15318	24204-24213	VBN	denotes	performed
T15319	24152-24154	IN	denotes	on
T15320	24155-24158	DT	denotes	the
T15321	24159-24166	NNS	denotes	results
T15322	24167-24169	IN	denotes	of
T15323	24170-24175	DT	denotes	these
T15324	24176-24183	NNS	denotes	studies
T15325	24183-24185	,	denotes	,
T15326	24185-24187	DT	denotes	an
T15327	24192-24199	NN	denotes	regimen
T15328	24188-24191	NN	denotes	EST
T15329	24200-24203	VBD	denotes	was
T15330	24214-24216	IN	denotes	in
T15331	24254-24263	VBN	denotes	exercised
T15332	24217-24222	WDT	denotes	which
T15333	24223-24226	NN	denotes	PGC
T15334	24227-24229	NN	denotes	1α
T15335	24226-24227	HYPH	denotes	-
T15336	24241-24248	NNS	denotes	animals
T15337	24229-24230	SYM	denotes	+
T15338	24230-24231	HYPH	denotes	/
T15339	24231-24232	SYM	denotes	+
T15340	24233-24240	NN	denotes	control
T15341	24249-24253	VBD	denotes	were
T15342	24264-24267	IN	denotes	for
T15343	24268-24269	DT	denotes	a
T15344	24270-24278	NN	denotes	duration
T15345	24279-24281	IN	denotes	of
T15346	24282-24284	CD	denotes	60
T15347	24285-24286	NN	denotes	s
T15348	24287-24289	TO	denotes	to
T15349	24290-24295	VB	denotes	match
T15350	24296-24299	DT	denotes	the
T15351	24310-24317	NN	denotes	average
T15352	24300-24309	VBN	denotes	predicted
T15353	24318-24321	IN	denotes	for
T15354	24322-24325	DT	denotes	the
T15355	24336-24340	NNS	denotes	mice
T15356	24326-24329	NN	denotes	PGC
T15357	24330-24332	NN	denotes	1α
T15358	24329-24330	HYPH	denotes	-
T15359	24332-24333	SYM	denotes	−
T15360	24333-24334	HYPH	denotes	/
T15361	24334-24335	SYM	denotes	−
T15362	24341-24342	-LRB-	denotes	(
T15363	24351-24353	NN	denotes	mo
T15364	24342-24346	NNS	denotes	ages
T15365	24347-24348	CD	denotes	6
T15366	24349-24350	CD	denotes	8
T15367	24348-24349	SYM	denotes	–
T15368	24353-24354	-RRB-	denotes	)
T15369	24354-24355	.	denotes	.
T15370	24355-24543	sentence	denotes	Echocardiographic images were obtained immediately following 60 s of exercise for the PGC-1α+/+ controls or at the point of exhaustion for PGC-1α−/− mice (mean 60 ± 6.1 s, range 45–90 s).
T15371	24356-24373	JJ	denotes	Echocardiographic
T15372	24374-24380	NNS	denotes	images
T15373	24386-24394	VBN	denotes	obtained
T15374	24381-24385	VBD	denotes	were
T15375	24395-24406	RB	denotes	immediately
T15376	24407-24416	VBG	denotes	following
T15377	24417-24419	CD	denotes	60
T15378	24420-24421	NN	denotes	s
T15379	24422-24424	IN	denotes	of
T15380	24425-24433	NN	denotes	exercise
T15381	24434-24437	IN	denotes	for
T15382	24438-24441	DT	denotes	the
T15383	24452-24460	NNS	denotes	controls
T15384	24442-24445	NN	denotes	PGC
T15385	24446-24448	NN	denotes	1α
T15386	24445-24446	HYPH	denotes	-
T15387	24448-24449	SYM	denotes	+
T15388	24449-24450	HYPH	denotes	/
T15389	24450-24451	SYM	denotes	+
T15390	24461-24463	CC	denotes	or
T15391	24464-24466	IN	denotes	at
T15392	24467-24470	DT	denotes	the
T15393	24471-24476	NN	denotes	point
T15394	24477-24479	IN	denotes	of
T15395	24480-24490	NN	denotes	exhaustion
T15396	24491-24494	IN	denotes	for
T15397	24495-24498	NN	denotes	PGC
T15398	24499-24501	NN	denotes	1α
T15399	24498-24499	HYPH	denotes	-
T15400	24505-24509	NNS	denotes	mice
T15401	24501-24502	SYM	denotes	−
T15402	24502-24503	HYPH	denotes	/
T15403	24503-24504	SYM	denotes	−
T15404	24510-24511	-LRB-	denotes	(
T15405	24540-24541	NN	denotes	s
T15406	24511-24515	NN	denotes	mean
T15407	24525-24526	NN	denotes	s
T15408	24516-24518	CD	denotes	60
T15409	24521-24524	CD	denotes	6.1
T15410	24519-24520	SYM	denotes	±
T15411	24526-24528	,	denotes	,
T15412	24528-24533	NN	denotes	range
T15413	24534-24536	CD	denotes	45
T15414	24537-24539	CD	denotes	90
T15415	24536-24537	SYM	denotes	–
T15416	24541-24542	-RRB-	denotes	)
T15417	24542-24543	.	denotes	.
T15418	24543-24690	sentence	denotes	Echocardiographic-determined left ventricular fractional shortening and heart rate were monitored for the 10-min period immediately post exercise.
T15419	24544-24561	JJ	denotes	Echocardiographic
T15420	24562-24572	VBN	denotes	determined
T15421	24561-24562	HYPH	denotes	-
T15422	24601-24611	NN	denotes	shortening
T15423	24573-24577	JJ	denotes	left
T15424	24590-24600	JJ	denotes	fractional
T15425	24578-24589	JJ	denotes	ventricular
T15426	24632-24641	VBN	denotes	monitored
T15427	24612-24615	CC	denotes	and
T15428	24616-24621	NN	denotes	heart
T15429	24622-24626	NN	denotes	rate
T15430	24627-24631	VBD	denotes	were
T15431	24642-24645	IN	denotes	for
T15432	24646-24649	DT	denotes	the
T15433	24657-24663	NN	denotes	period
T15434	24650-24652	CD	denotes	10
T15435	24653-24656	NN	denotes	min
T15436	24652-24653	HYPH	denotes	-
T15437	24664-24675	RB	denotes	immediately
T15438	24676-24680	IN	denotes	post
T15439	24681-24689	NN	denotes	exercise
T15440	24689-24690	.	denotes	.
T15441	24690-24812	sentence	denotes	The mean heart rate of the PGC-1α−/− mice exhibited an inappropriate decline during the post exercise period (Figure 5A).
T15442	24691-24694	DT	denotes	The
T15443	24706-24710	NN	denotes	rate
T15444	24695-24699	JJ	denotes	mean
T15445	24700-24705	NN	denotes	heart
T15446	24733-24742	VBD	denotes	exhibited
T15447	24711-24713	IN	denotes	of
T15448	24714-24717	DT	denotes	the
T15449	24728-24732	NNS	denotes	mice
T15450	24718-24721	NN	denotes	PGC
T15451	24722-24724	NN	denotes	1α
T15452	24721-24722	HYPH	denotes	-
T15453	24724-24725	SYM	denotes	−
T15454	24725-24726	HYPH	denotes	/
T15455	24726-24727	SYM	denotes	−
T15456	24743-24745	DT	denotes	an
T15457	24760-24767	NN	denotes	decline
T15458	24746-24759	JJ	denotes	inappropriate
T15459	24768-24774	IN	denotes	during
T15460	24775-24778	DT	denotes	the
T15461	24793-24799	NN	denotes	period
T15462	24779-24783	JJ	denotes	post
T15463	24784-24792	NN	denotes	exercise
T15464	24800-24801	-LRB-	denotes	(
T15465	24808-24810	NN	denotes	5A
T15466	24801-24807	NN	denotes	Figure
T15467	24810-24811	-RRB-	denotes	)
T15468	24811-24812	.	denotes	.
T15469	24812-25025	sentence	denotes	In addition, echocardiographically determined left ventricular fractional shortening was decreased in the PGC-1α−/− mice, but not the PGC-1α+/+ mice during the first 4 min of the post exercise period (Figure 5A).
T15470	24813-24815	IN	denotes	In
T15471	24902-24911	VBN	denotes	decreased
T15472	24816-24824	NN	denotes	addition
T15473	24824-24826	,	denotes	,
T15474	24826-24847	RB	denotes	echocardiographically
T15475	24848-24858	VBN	denotes	determined
T15476	24887-24897	NN	denotes	shortening
T15477	24859-24863	JJ	denotes	left
T15478	24864-24875	JJ	denotes	ventricular
T15479	24876-24886	JJ	denotes	fractional
T15480	24898-24901	VBD	denotes	was
T15481	24912-24914	IN	denotes	in
T15482	24915-24918	DT	denotes	the
T15483	24929-24933	NNS	denotes	mice
T15484	24919-24922	NN	denotes	PGC
T15485	24923-24925	NN	denotes	1α
T15486	24922-24923	HYPH	denotes	-
T15487	24925-24926	SYM	denotes	−
T15488	24926-24927	HYPH	denotes	/
T15489	24927-24928	SYM	denotes	−
T15490	24933-24935	,	denotes	,
T15491	24935-24938	CC	denotes	but
T15492	24939-24942	RB	denotes	not
T15493	24943-24946	DT	denotes	the
T15494	24957-24961	NNS	denotes	mice
T15495	24947-24950	NN	denotes	PGC
T15496	24951-24953	NN	denotes	1α
T15497	24950-24951	HYPH	denotes	-
T15498	24953-24954	SYM	denotes	+
T15499	24954-24955	HYPH	denotes	/
T15500	24955-24956	SYM	denotes	+
T15501	24962-24968	IN	denotes	during
T15502	24969-24972	DT	denotes	the
T15503	24981-24984	NN	denotes	min
T15504	24973-24978	JJ	denotes	first
T15505	24979-24980	CD	denotes	4
T15506	24985-24987	IN	denotes	of
T15507	24988-24991	DT	denotes	the
T15508	25006-25012	NN	denotes	period
T15509	24992-24996	JJ	denotes	post
T15510	24997-25005	NN	denotes	exercise
T15511	25013-25014	-LRB-	denotes	(
T15512	25021-25023	NN	denotes	5A
T15513	25014-25020	NN	denotes	Figure
T15514	25023-25024	-RRB-	denotes	)
T15515	25024-25025	.	denotes	.
T15516	25025-26358	sentence	denotes	Figure 5 Abnormal Cardiac Response to Physiologic Stress in PGC-1α−/− Mice (A) Exercise echocardiographic studies. PGC-1α+/+ (n = 4) and PGC-1α−/− (n = 8) female mice aged 6–8 mo were subjected to an exercise protocol on a motorized treadmill. This protocol was designed such that the PGC-1α−/− mice ran to exhaustion based on the results of the exercise studies shown in Figure 4. Accordingly, an exercise regimen of 60 s was used for both groups. The graphs depict the heart rate (left graph) and echocardiographically-determined ventricular fractional shortening (FS) as a percent (right graph). Responses were monitored for 10 min immediately post exercise. (B) In vivo hemodynamic response to the β1,α1-adrenergic agonist dobutamine. Male and female PGC-1α+/+ (n = 6) and PGC-1α−/− (n = 6) mice at 10–12 wk of age were anesthetized and a 1.4-French Millar catheter was placed through the carotid artery into the left ventricle as described in Materials and Methods. Heart rate (left graph) and a measurement of ventricular systolic performance, dP/dt (right graph), were measured following infusion of dobutamine. * p < 0.05. The results of the EST did not distinguish between a primary cardiac abnormality versus effects secondary to the exhaustion caused by reduced exercise tolerance related to skeletal muscle dysfunction.
T15517	26158-26161	DT	denotes	The
T15518	26162-26169	NNS	denotes	results
T15519	26189-26200	VB	denotes	distinguish
T15520	26170-26172	IN	denotes	of
T15521	26173-26176	DT	denotes	the
T15522	26177-26180	NN	denotes	EST
T15523	26181-26184	VBD	denotes	did
T15524	26185-26188	RB	denotes	not
T15525	26201-26208	IN	denotes	between
T15526	26209-26210	DT	denotes	a
T15527	26227-26238	NN	denotes	abnormality
T15528	26211-26218	JJ	denotes	primary
T15529	26219-26226	JJ	denotes	cardiac
T15530	26239-26245	CC	denotes	versus
T15531	26246-26253	NNS	denotes	effects
T15532	26254-26263	JJ	denotes	secondary
T15533	26264-26266	IN	denotes	to
T15534	26267-26270	DT	denotes	the
T15535	26271-26281	NN	denotes	exhaustion
T15536	26282-26288	VBN	denotes	caused
T15537	26289-26291	IN	denotes	by
T15538	26292-26299	VBN	denotes	reduced
T15539	26309-26318	NN	denotes	tolerance
T15540	26300-26308	NN	denotes	exercise
T15541	26319-26326	VBN	denotes	related
T15542	26327-26329	IN	denotes	to
T15543	26330-26338	JJ	denotes	skeletal
T15544	26339-26345	NN	denotes	muscle
T15545	26346-26357	NN	denotes	dysfunction
T15546	26357-26358	.	denotes	.
T15547	26358-26486	sentence	denotes	To directly assess cardiac function, the hearts of PGC-1α−/− and PGC-1α+/+ mice were isolated and perfused in the working mode.
T15548	26359-26361	TO	denotes	To
T15549	26371-26377	VB	denotes	assess
T15550	26362-26370	RB	denotes	directly
T15551	26444-26452	VBN	denotes	isolated
T15552	26378-26385	JJ	denotes	cardiac
T15553	26386-26394	NN	denotes	function
T15554	26394-26396	,	denotes	,
T15555	26396-26399	DT	denotes	the
T15556	26400-26406	NNS	denotes	hearts
T15557	26407-26409	IN	denotes	of
T15558	26410-26413	NN	denotes	PGC
T15559	26414-26416	NN	denotes	1α
T15560	26413-26414	HYPH	denotes	-
T15561	26434-26438	NNS	denotes	mice
T15562	26416-26417	SYM	denotes	−
T15563	26417-26418	HYPH	denotes	/
T15564	26418-26419	SYM	denotes	−
T15565	26420-26423	CC	denotes	and
T15566	26424-26427	NN	denotes	PGC
T15567	26428-26430	NN	denotes	1α
T15568	26427-26428	HYPH	denotes	-
T15569	26430-26431	SYM	denotes	+
T15570	26431-26432	HYPH	denotes	/
T15571	26432-26433	SYM	denotes	+
T15572	26439-26443	VBD	denotes	were
T15573	26453-26456	CC	denotes	and
T15574	26457-26465	VBN	denotes	perfused
T15575	26466-26468	IN	denotes	in
T15576	26469-26472	DT	denotes	the
T15577	26481-26485	NN	denotes	mode
T15578	26473-26480	NN	denotes	working
T15579	26485-26486	.	denotes	.
T15580	26486-26675	sentence	denotes	Hearts isolated from PGC-1α−/− mice generated lower cardiac work (cardiac output multiplied by peak systolic pressure) compared to PGC-1α+/+ mice at identical loading conditions (Table 1).
T15581	26487-26493	NNS	denotes	Hearts
T15582	26523-26532	VBD	denotes	generated
T15583	26494-26502	VBN	denotes	isolated
T15584	26503-26507	IN	denotes	from
T15585	26508-26511	NN	denotes	PGC
T15586	26512-26514	NN	denotes	1α
T15587	26511-26512	HYPH	denotes	-
T15588	26518-26522	NNS	denotes	mice
T15589	26514-26515	SYM	denotes	−
T15590	26515-26516	HYPH	denotes	/
T15591	26516-26517	SYM	denotes	−
T15592	26533-26538	JJR	denotes	lower
T15593	26547-26551	NN	denotes	work
T15594	26539-26546	JJ	denotes	cardiac
T15595	26552-26553	-LRB-	denotes	(
T15596	26553-26560	JJ	denotes	cardiac
T15597	26561-26567	NN	denotes	output
T15598	26568-26578	VBN	denotes	multiplied
T15599	26579-26581	IN	denotes	by
T15600	26582-26586	NN	denotes	peak
T15601	26596-26604	NN	denotes	pressure
T15602	26587-26595	JJ	denotes	systolic
T15603	26604-26605	-RRB-	denotes	)
T15604	26606-26614	VBN	denotes	compared
T15605	26615-26617	IN	denotes	to
T15606	26618-26621	NN	denotes	PGC
T15607	26622-26624	NN	denotes	1α
T15608	26621-26622	HYPH	denotes	-
T15609	26628-26632	NNS	denotes	mice
T15610	26624-26625	SYM	denotes	+
T15611	26625-26626	HYPH	denotes	/
T15612	26626-26627	SYM	denotes	+
T15613	26633-26635	IN	denotes	at
T15614	26636-26645	JJ	denotes	identical
T15615	26654-26664	NNS	denotes	conditions
T15616	26646-26653	NN	denotes	loading
T15617	26665-26666	-LRB-	denotes	(
T15618	26666-26671	NN	denotes	Table
T15619	26672-26673	CD	denotes	1
T15620	26673-26674	-RRB-	denotes	)
T15621	26674-26675	.	denotes	.
T15622	26675-26753	sentence	denotes	This reduction in cardiac work was due to a reduced cardiac output (Table 1).
T15623	26676-26680	DT	denotes	This
T15624	26681-26690	NN	denotes	reduction
T15625	26707-26710	VBD	denotes	was
T15626	26691-26693	IN	denotes	in
T15627	26694-26701	JJ	denotes	cardiac
T15628	26702-26706	NN	denotes	work
T15629	26711-26714	IN	denotes	due
T15630	26715-26717	IN	denotes	to
T15631	26718-26719	DT	denotes	a
T15632	26736-26742	NN	denotes	output
T15633	26720-26727	VBN	denotes	reduced
T15634	26728-26735	JJ	denotes	cardiac
T15635	26743-26744	-LRB-	denotes	(
T15636	26744-26749	NN	denotes	Table
T15637	26750-26751	CD	denotes	1
T15638	26751-26752	-RRB-	denotes	)
T15639	26752-26753	.	denotes	.
T15640	26753-26962	sentence	denotes	The relative contribution of heart rate and stroke volume to diminished cardiac output in the PGC-1α−/− mice could not be delineated, because both were decreased but neither to a significant degree (Table 1).
T15641	26754-26757	DT	denotes	The
T15642	26767-26779	NN	denotes	contribution
T15643	26758-26766	JJ	denotes	relative
T15644	26876-26886	VBN	denotes	delineated
T15645	26780-26782	IN	denotes	of
T15646	26783-26788	NN	denotes	heart
T15647	26789-26793	NN	denotes	rate
T15648	26794-26797	CC	denotes	and
T15649	26798-26804	NN	denotes	stroke
T15650	26805-26811	NN	denotes	volume
T15651	26812-26814	IN	denotes	to
T15652	26815-26825	VBN	denotes	diminished
T15653	26834-26840	NN	denotes	output
T15654	26826-26833	JJ	denotes	cardiac
T15655	26841-26843	IN	denotes	in
T15656	26844-26847	DT	denotes	the
T15657	26858-26862	NNS	denotes	mice
T15658	26848-26851	NN	denotes	PGC
T15659	26852-26854	NN	denotes	1α
T15660	26851-26852	HYPH	denotes	-
T15661	26854-26855	SYM	denotes	−
T15662	26855-26856	HYPH	denotes	/
T15663	26856-26857	SYM	denotes	−
T15664	26863-26868	MD	denotes	could
T15665	26869-26872	RB	denotes	not
T15666	26873-26875	VB	denotes	be
T15667	26886-26888	,	denotes	,
T15668	26888-26895	IN	denotes	because
T15669	26906-26915	VBN	denotes	decreased
T15670	26896-26900	DT	denotes	both
T15671	26901-26905	VBD	denotes	were
T15672	26916-26919	CC	denotes	but
T15673	26920-26927	CC	denotes	neither
T15674	26928-26930	IN	denotes	to
T15675	26931-26932	DT	denotes	a
T15676	26945-26951	NN	denotes	degree
T15677	26933-26944	JJ	denotes	significant
T15678	26952-26953	-LRB-	denotes	(
T15679	26953-26958	NN	denotes	Table
T15680	26959-26960	CD	denotes	1
T15681	26960-26961	-RRB-	denotes	)
T15682	26961-26962	.	denotes	.
T15683	26962-27181	sentence	denotes	To further distinguish between abnormalities in heart rate and ventricular function, in vivo hemodynamic response to the β1,α1-adrenergic-selective agonist dobutamine was evaluated using a miniaturized Millar catheter.
T15684	26963-26965	TO	denotes	To
T15685	26974-26985	VB	denotes	distinguish
T15686	26966-26973	RB	denotes	further
T15687	27134-27143	VBN	denotes	evaluated
T15688	26986-26993	IN	denotes	between
T15689	26994-27007	NNS	denotes	abnormalities
T15690	27008-27010	IN	denotes	in
T15691	27011-27016	NN	denotes	heart
T15692	27017-27021	NN	denotes	rate
T15693	27022-27025	CC	denotes	and
T15694	27026-27037	JJ	denotes	ventricular
T15695	27038-27046	NN	denotes	function
T15696	27046-27048	,	denotes	,
T15697	27048-27050	FW	denotes	in
T15698	27051-27055	FW	denotes	vivo
T15699	27068-27076	NN	denotes	response
T15700	27056-27067	JJ	denotes	hemodynamic
T15701	27077-27079	IN	denotes	to
T15702	27080-27083	DT	denotes	the
T15703	27111-27118	NN	denotes	agonist
T15704	27084-27086	NN	denotes	β1
T15705	27087-27089	NN	denotes	α1
T15706	27086-27087	,	denotes	,
T15707	27090-27100	JJ	denotes	adrenergic
T15708	27089-27090	HYPH	denotes	-
T15709	27101-27110	JJ	denotes	selective
T15710	27100-27101	HYPH	denotes	-
T15711	27119-27129	NN	denotes	dobutamine
T15712	27130-27133	VBD	denotes	was
T15713	27144-27149	VBG	denotes	using
T15714	27150-27151	DT	denotes	a
T15715	27172-27180	NN	denotes	catheter
T15716	27152-27164	VBN	denotes	miniaturized
T15717	27165-27171	NNP	denotes	Millar
T15718	27180-27181	.	denotes	.
T15719	27181-27301	sentence	denotes	The ventricular functional response to dobutamine was similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 5B, right graph).
T15720	27182-27185	DT	denotes	The
T15721	27209-27217	NN	denotes	response
T15722	27186-27197	JJ	denotes	ventricular
T15723	27198-27208	JJ	denotes	functional
T15724	27232-27235	VBD	denotes	was
T15725	27218-27220	IN	denotes	to
T15726	27221-27231	NN	denotes	dobutamine
T15727	27236-27243	JJ	denotes	similar
T15728	27244-27246	IN	denotes	in
T15729	27247-27250	NN	denotes	PGC
T15730	27251-27253	NN	denotes	1α
T15731	27250-27251	HYPH	denotes	-
T15732	27271-27275	NNS	denotes	mice
T15733	27253-27254	SYM	denotes	+
T15734	27254-27255	HYPH	denotes	/
T15735	27255-27256	SYM	denotes	+
T15736	27257-27260	CC	denotes	and
T15737	27261-27264	NN	denotes	PGC
T15738	27265-27267	NN	denotes	1α
T15739	27264-27265	HYPH	denotes	-
T15740	27267-27268	SYM	denotes	−
T15741	27268-27269	HYPH	denotes	/
T15742	27269-27270	SYM	denotes	−
T15743	27276-27277	-LRB-	denotes	(
T15744	27294-27299	NN	denotes	graph
T15745	27277-27283	NN	denotes	Figure
T15746	27284-27286	NN	denotes	5B
T15747	27286-27288	,	denotes	,
T15748	27288-27293	JJ	denotes	right
T15749	27299-27300	-RRB-	denotes	)
T15750	27300-27301	.	denotes	.
T15751	27301-27432	sentence	denotes	However, PGC-1α−/− mice exhibited a significantly blunted heart rate response to β-adrenergic stimulation (Figure 5B, left graph).
T15752	27302-27309	RB	denotes	However
T15753	27326-27335	VBD	denotes	exhibited
T15754	27309-27311	,	denotes	,
T15755	27311-27314	NN	denotes	PGC
T15756	27315-27317	NN	denotes	1α
T15757	27314-27315	HYPH	denotes	-
T15758	27321-27325	NNS	denotes	mice
T15759	27317-27318	SYM	denotes	−
T15760	27318-27319	HYPH	denotes	/
T15761	27319-27320	SYM	denotes	−
T15762	27336-27337	DT	denotes	a
T15763	27371-27379	NN	denotes	response
T15764	27338-27351	RB	denotes	significantly
T15765	27352-27359	VBN	denotes	blunted
T15766	27360-27365	NN	denotes	heart
T15767	27366-27370	NN	denotes	rate
T15768	27380-27382	IN	denotes	to
T15769	27383-27384	NN	denotes	β
T15770	27385-27395	JJ	denotes	adrenergic
T15771	27384-27385	HYPH	denotes	-
T15772	27396-27407	NN	denotes	stimulation
T15773	27408-27409	-LRB-	denotes	(
T15774	27425-27430	NN	denotes	graph
T15775	27409-27415	NN	denotes	Figure
T15776	27416-27418	NN	denotes	5B
T15777	27418-27420	,	denotes	,
T15778	27420-27424	JJ	denotes	left
T15779	27430-27431	-RRB-	denotes	)
T15780	27431-27432	.	denotes	.
T15781	27432-27664	sentence	denotes	Taken together with the EST, these results strongly suggest that the PGC-1α−/− hearts are unable to mount an appropriate chronotropic response to exercise and other physiologic stimuli that activate β-adrenergic input to the heart.
T15782	27433-27438	VBN	denotes	Taken
T15783	27485-27492	VBP	denotes	suggest
T15784	27439-27447	RB	denotes	together
T15785	27448-27452	IN	denotes	with
T15786	27453-27456	DT	denotes	the
T15787	27457-27460	NN	denotes	EST
T15788	27460-27462	,	denotes	,
T15789	27462-27467	DT	denotes	these
T15790	27468-27475	NNS	denotes	results
T15791	27476-27484	RB	denotes	strongly
T15792	27493-27497	IN	denotes	that
T15793	27519-27522	VBP	denotes	are
T15794	27498-27501	DT	denotes	the
T15795	27512-27518	NNS	denotes	hearts
T15796	27502-27505	NN	denotes	PGC
T15797	27506-27508	NN	denotes	1α
T15798	27505-27506	HYPH	denotes	-
T15799	27508-27509	SYM	denotes	−
T15800	27509-27510	HYPH	denotes	/
T15801	27510-27511	SYM	denotes	−
T15802	27523-27529	JJ	denotes	unable
T15803	27530-27532	TO	denotes	to
T15804	27533-27538	VB	denotes	mount
T15805	27539-27541	DT	denotes	an
T15806	27567-27575	NN	denotes	response
T15807	27542-27553	JJ	denotes	appropriate
T15808	27554-27566	JJ	denotes	chronotropic
T15809	27576-27578	IN	denotes	to
T15810	27579-27587	NN	denotes	exercise
T15811	27588-27591	CC	denotes	and
T15812	27592-27597	JJ	denotes	other
T15813	27610-27617	NNS	denotes	stimuli
T15814	27598-27609	JJ	denotes	physiologic
T15815	27618-27622	WDT	denotes	that
T15816	27623-27631	VBP	denotes	activate
T15817	27632-27633	NN	denotes	β
T15818	27634-27644	JJ	denotes	adrenergic
T15819	27633-27634	HYPH	denotes	-
T15820	27645-27650	NN	denotes	input
T15821	27651-27653	IN	denotes	to
T15822	27654-27657	DT	denotes	the
T15823	27658-27663	NN	denotes	heart
T15824	27663-27664	.	denotes	.
T15825	27664-27738	sentence	denotes	However, our results did not reveal evidence for contractile dysfunction.
T15826	27665-27672	RB	denotes	However
T15827	27694-27700	VB	denotes	reveal
T15828	27672-27674	,	denotes	,
T15829	27674-27677	PRP$	denotes	our
T15830	27678-27685	NNS	denotes	results
T15831	27686-27689	VBD	denotes	did
T15832	27690-27693	RB	denotes	not
T15833	27701-27709	NN	denotes	evidence
T15834	27710-27713	IN	denotes	for
T15835	27714-27725	JJ	denotes	contractile
T15836	27726-27737	NN	denotes	dysfunction
T15837	27737-27738	.	denotes	.
T17367	27879-27882	NN	denotes	PGC
T17368	27883-27885	NN	denotes	1α
T17369	27882-27883	HYPH	denotes	-
T17370	27889-27893	NNS	denotes	Mice
T17371	27885-27886	SYM	denotes	−
T17372	27886-27887	HYPH	denotes	/
T17373	27887-27888	SYM	denotes	−
T17374	27894-27901	VBP	denotes	Exhibit
T17375	27902-27904	DT	denotes	an
T17376	27926-27934	NN	denotes	Response
T17377	27905-27913	JJ	denotes	Abnormal
T17378	27914-27925	JJ	denotes	Thermogenic
T17379	27934-28079	sentence	denotes	PGC-1α has been implicated as an inducible regulator of mitochondrial respiratory uncoupling, an important source of heat production in BAT [2].
T17380	27935-27938	NN	denotes	PGC
T17381	27939-27941	NN	denotes	1α
T17382	27938-27939	HYPH	denotes	-
T17383	27951-27961	VBN	denotes	implicated
T17384	27942-27945	VBZ	denotes	has
T17385	27946-27950	VBN	denotes	been
T17386	27962-27964	IN	denotes	as
T17387	27965-27967	DT	denotes	an
T17388	27978-27987	NN	denotes	regulator
T17389	27968-27977	JJ	denotes	inducible
T17390	27988-27990	IN	denotes	of
T17391	27991-28004	JJ	denotes	mitochondrial
T17392	28017-28027	NN	denotes	uncoupling
T17393	28005-28016	JJ	denotes	respiratory
T17394	28027-28029	,	denotes	,
T17395	28029-28031	DT	denotes	an
T17396	28042-28048	NN	denotes	source
T17397	28032-28041	JJ	denotes	important
T17398	28049-28051	IN	denotes	of
T17399	28052-28056	NN	denotes	heat
T17400	28057-28067	NN	denotes	production
T17401	28068-28070	IN	denotes	in
T17402	28071-28074	NN	denotes	BAT
T17403	28075-28076	-LRB-	denotes	[
T17404	28076-28077	CD	denotes	2
T17405	28077-28078	-RRB-	denotes	]
T17406	28078-28079	.	denotes	.
T17407	28079-28289	sentence	denotes	To determine whether PGC-1α is necessary for an appropriate thermogenic response, PGC-1α+/+ and PGC-1α−/− mice were subjected to cold exposure (4 °C) for a 5-h period while core body temperature was monitored.
T17408	28080-28082	TO	denotes	To
T17409	28083-28092	VB	denotes	determine
T17410	28196-28205	VBN	denotes	subjected
T17411	28093-28100	IN	denotes	whether
T17412	28108-28110	VBZ	denotes	is
T17413	28101-28104	NN	denotes	PGC
T17414	28105-28107	NN	denotes	1α
T17415	28104-28105	HYPH	denotes	-
T17416	28111-28120	JJ	denotes	necessary
T17417	28121-28124	IN	denotes	for
T17418	28125-28127	DT	denotes	an
T17419	28152-28160	NN	denotes	response
T17420	28128-28139	JJ	denotes	appropriate
T17421	28140-28151	JJ	denotes	thermogenic
T17422	28160-28162	,	denotes	,
T17423	28162-28165	NN	denotes	PGC
T17424	28166-28168	NN	denotes	1α
T17425	28165-28166	HYPH	denotes	-
T17426	28186-28190	NNS	denotes	mice
T17427	28168-28169	SYM	denotes	+
T17428	28169-28170	HYPH	denotes	/
T17429	28170-28171	SYM	denotes	+
T17430	28172-28175	CC	denotes	and
T17431	28176-28179	NN	denotes	PGC
T17432	28180-28182	NN	denotes	1α
T17433	28179-28180	HYPH	denotes	-
T17434	28182-28183	SYM	denotes	−
T17435	28183-28184	HYPH	denotes	/
T17436	28184-28185	SYM	denotes	−
T17437	28191-28195	VBD	denotes	were
T17438	28206-28208	IN	denotes	to
T17439	28209-28213	NN	denotes	cold
T17440	28214-28222	NN	denotes	exposure
T17441	28223-28224	-LRB-	denotes	(
T17442	28226-28228	NN	denotes	°C
T17443	28224-28225	CD	denotes	4
T17444	28228-28229	-RRB-	denotes	)
T17445	28230-28233	IN	denotes	for
T17446	28234-28235	DT	denotes	a
T17447	28240-28246	NN	denotes	period
T17448	28236-28237	CD	denotes	5
T17449	28238-28239	NN	denotes	h
T17450	28237-28238	HYPH	denotes	-
T17451	28247-28252	IN	denotes	while
T17452	28279-28288	VBN	denotes	monitored
T17453	28253-28257	NN	denotes	core
T17454	28263-28274	NN	denotes	temperature
T17455	28258-28262	NN	denotes	body
T17456	28275-28278	VBD	denotes	was
T17457	28288-28289	.	denotes	.
T17458	28289-28400	sentence	denotes	PGC-1α−/− mice exhibited a markedly abnormal drop in core temperature compared to the WT controls (Figure 6A).
T17459	28290-28293	NN	denotes	PGC
T17460	28294-28296	NN	denotes	1α
T17461	28293-28294	HYPH	denotes	-
T17462	28300-28304	NNS	denotes	mice
T17463	28296-28297	SYM	denotes	−
T17464	28297-28298	HYPH	denotes	/
T17465	28298-28299	SYM	denotes	−
T17466	28305-28314	VBD	denotes	exhibited
T17467	28315-28316	DT	denotes	a
T17468	28335-28339	NN	denotes	drop
T17469	28317-28325	RB	denotes	markedly
T17470	28326-28334	JJ	denotes	abnormal
T17471	28340-28342	IN	denotes	in
T17472	28343-28347	NN	denotes	core
T17473	28348-28359	NN	denotes	temperature
T17474	28360-28368	VBN	denotes	compared
T17475	28369-28371	IN	denotes	to
T17476	28372-28375	DT	denotes	the
T17477	28379-28387	NNS	denotes	controls
T17478	28376-28378	NN	denotes	WT
T17479	28388-28389	-LRB-	denotes	(
T17480	28396-28398	NN	denotes	6A
T17481	28389-28395	NN	denotes	Figure
T17482	28398-28399	-RRB-	denotes	)
T17483	28399-28400	.	denotes	.
T17484	28400-28582	sentence	denotes	Specifically, the mean decline in core temperature was greater than 12 °C at the 5-h time point in PGC-1α−/− mice, compared to an approximately 3 °C decrement in PGC-1α+/+ controls.
T17485	28401-28413	RB	denotes	Specifically
T17486	28452-28455	VBD	denotes	was
T17487	28413-28415	,	denotes	,
T17488	28415-28418	DT	denotes	the
T17489	28424-28431	NN	denotes	decline
T17490	28419-28423	NN	denotes	mean
T17491	28432-28434	IN	denotes	in
T17492	28435-28439	NN	denotes	core
T17493	28440-28451	NN	denotes	temperature
T17494	28456-28463	JJR	denotes	greater
T17495	28464-28468	IN	denotes	than
T17496	28469-28471	CD	denotes	12
T17497	28472-28474	NN	denotes	°C
T17498	28475-28477	IN	denotes	at
T17499	28478-28481	DT	denotes	the
T17500	28491-28496	NN	denotes	point
T17501	28482-28483	CD	denotes	5
T17502	28484-28485	NN	denotes	h
T17503	28483-28484	HYPH	denotes	-
T17504	28486-28490	NN	denotes	time
T17505	28497-28499	IN	denotes	in
T17506	28500-28503	NN	denotes	PGC
T17507	28504-28506	NN	denotes	1α
T17508	28503-28504	HYPH	denotes	-
T17509	28510-28514	NNS	denotes	mice
T17510	28506-28507	SYM	denotes	−
T17511	28507-28508	HYPH	denotes	/
T17512	28508-28509	SYM	denotes	−
T17513	28514-28516	,	denotes	,
T17514	28516-28524	VBN	denotes	compared
T17515	28525-28527	IN	denotes	to
T17516	28528-28530	DT	denotes	an
T17517	28550-28559	NN	denotes	decrement
T17518	28531-28544	RB	denotes	approximately
T17519	28545-28546	CD	denotes	3
T17520	28547-28549	NN	denotes	°C
T17521	28560-28562	IN	denotes	in
T17522	28563-28566	NN	denotes	PGC
T17523	28567-28569	NN	denotes	1α
T17524	28566-28567	HYPH	denotes	-
T17525	28573-28581	NNS	denotes	controls
T17526	28569-28570	SYM	denotes	+
T17527	28570-28571	HYPH	denotes	/
T17528	28571-28572	SYM	denotes	+
T17529	28581-28582	.	denotes	.
T17530	28582-28713	sentence	denotes	Although this thermogenic phenotype was consistently present in mice aged 28–37 d, it was absent in older mice (unpublished data).
T17531	28583-28591	IN	denotes	Although
T17532	28619-28622	VBD	denotes	was
T17533	28592-28596	DT	denotes	this
T17534	28609-28618	NN	denotes	phenotype
T17535	28597-28608	JJ	denotes	thermogenic
T17536	28669-28672	VBD	denotes	was
T17537	28623-28635	RB	denotes	consistently
T17538	28636-28643	JJ	denotes	present
T17539	28644-28646	IN	denotes	in
T17540	28647-28651	NNS	denotes	mice
T17541	28652-28656	VBN	denotes	aged
T17542	28657-28659	CD	denotes	28
T17543	28660-28662	CD	denotes	37
T17544	28659-28660	SYM	denotes	–
T17545	28663-28664	NN	denotes	d
T17546	28664-28666	,	denotes	,
T17547	28666-28668	PRP	denotes	it
T17548	28673-28679	JJ	denotes	absent
T17549	28680-28682	IN	denotes	in
T17550	28683-28688	JJR	denotes	older
T17551	28689-28693	NNS	denotes	mice
T17552	28694-28695	-LRB-	denotes	(
T17553	28707-28711	NNS	denotes	data
T17554	28695-28706	JJ	denotes	unpublished
T17555	28711-28712	-RRB-	denotes	)
T17556	28712-28713	.	denotes	.
T17557	28713-29997	sentence	denotes	Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The histologic appearance and neutral lipid stores of BAT were assessed as an initial step to characterize the thermogenic phenotype exhibited by PGC-1α−/− mice.
T17558	29836-29839	DT	denotes	The
T17559	29851-29861	NN	denotes	appearance
T17560	29840-29850	JJ	denotes	histologic
T17561	29899-29907	VBN	denotes	assessed
T17562	29862-29865	CC	denotes	and
T17563	29866-29873	JJ	denotes	neutral
T17564	29880-29886	NNS	denotes	stores
T17565	29874-29879	NN	denotes	lipid
T17566	29887-29889	IN	denotes	of
T17567	29890-29893	NN	denotes	BAT
T17568	29894-29898	VBD	denotes	were
T17569	29908-29910	IN	denotes	as
T17570	29911-29913	DT	denotes	an
T17571	29922-29926	NN	denotes	step
T17572	29914-29921	JJ	denotes	initial
T17573	29927-29929	TO	denotes	to
T17574	29930-29942	VB	denotes	characterize
T17575	29943-29946	DT	denotes	the
T17576	29959-29968	NN	denotes	phenotype
T17577	29947-29958	JJ	denotes	thermogenic
T17578	29969-29978	VBN	denotes	exhibited
T17579	29979-29981	IN	denotes	by
T17580	29982-29985	NN	denotes	PGC
T17581	29986-29988	NN	denotes	1α
T17582	29985-29986	HYPH	denotes	-
T17583	29992-29996	NNS	denotes	mice
T17584	29988-29989	SYM	denotes	−
T17585	29989-29990	HYPH	denotes	/
T17586	29990-29991	SYM	denotes	−
T17587	29996-29997	.	denotes	.
T17588	29997-30057	sentence	denotes	Histologic and lipid quantification studies were performed.
T17589	29998-30008	JJ	denotes	Histologic
T17590	30034-30041	NNS	denotes	studies
T17591	30009-30012	CC	denotes	and
T17592	30013-30018	NN	denotes	lipid
T17593	30019-30033	NN	denotes	quantification
T17594	30047-30056	VBN	denotes	performed
T17595	30042-30046	VBD	denotes	were
T17596	30056-30057	.	denotes	.
T17597	30057-30248	sentence	denotes	Electron microscopic analyses indicated that the mitochondrial ultrastructure was similar in BAT isolated from PGC-1α−/− and PGC-1α+/+ mice before and after cold exposure (unpublished data).
T17598	30058-30066	NN	denotes	Electron
T17599	30067-30078	JJ	denotes	microscopic
T17600	30079-30087	NNS	denotes	analyses
T17601	30088-30097	VBD	denotes	indicated
T17602	30098-30102	IN	denotes	that
T17603	30136-30139	VBD	denotes	was
T17604	30103-30106	DT	denotes	the
T17605	30121-30135	NN	denotes	ultrastructure
T17606	30107-30120	JJ	denotes	mitochondrial
T17607	30140-30147	JJ	denotes	similar
T17608	30148-30150	IN	denotes	in
T17609	30151-30154	NN	denotes	BAT
T17610	30155-30163	VBN	denotes	isolated
T17611	30164-30168	IN	denotes	from
T17612	30169-30172	NN	denotes	PGC
T17613	30173-30175	NN	denotes	1α
T17614	30172-30173	HYPH	denotes	-
T17615	30193-30197	NNS	denotes	mice
T17616	30175-30176	SYM	denotes	−
T17617	30176-30177	HYPH	denotes	/
T17618	30177-30178	SYM	denotes	−
T17619	30179-30182	CC	denotes	and
T17620	30183-30186	NN	denotes	PGC
T17621	30187-30189	NN	denotes	1α
T17622	30186-30187	HYPH	denotes	-
T17623	30189-30190	SYM	denotes	+
T17624	30190-30191	HYPH	denotes	/
T17625	30191-30192	SYM	denotes	+
T17626	30198-30204	IN	denotes	before
T17627	30205-30208	CC	denotes	and
T17628	30209-30214	IN	denotes	after
T17629	30215-30219	NN	denotes	cold
T17630	30220-30228	NN	denotes	exposure
T17631	30229-30230	-LRB-	denotes	(
T17632	30242-30246	NNS	denotes	data
T17633	30230-30241	JJ	denotes	unpublished
T17634	30246-30247	-RRB-	denotes	)
T17635	30247-30248	.	denotes	.
T17636	30248-30347	sentence	denotes	In addition, levels of BAT triglyceride were similar between the two genotypes (unpublished data).
T17637	30249-30251	IN	denotes	In
T17638	30289-30293	VBD	denotes	were
T17639	30252-30260	NN	denotes	addition
T17640	30260-30262	,	denotes	,
T17641	30262-30268	NNS	denotes	levels
T17642	30269-30271	IN	denotes	of
T17643	30272-30275	NN	denotes	BAT
T17644	30276-30288	NN	denotes	triglyceride
T17645	30294-30301	JJ	denotes	similar
T17646	30302-30309	IN	denotes	between
T17647	30310-30313	DT	denotes	the
T17648	30318-30327	NNS	denotes	genotypes
T17649	30314-30317	CD	denotes	two
T17650	30328-30329	-LRB-	denotes	(
T17651	30341-30345	NNS	denotes	data
T17652	30329-30340	JJ	denotes	unpublished
T17653	30345-30346	-RRB-	denotes	)
T17654	30346-30347	.	denotes	.
T17655	30347-30455	sentence	denotes	UCP-1 is a cold-inducible protein involved in mitochondrial respiratory uncoupling to generate heat in BAT.
T17656	30348-30351	NN	denotes	UCP
T17657	30354-30356	VBZ	denotes	is
T17658	30351-30352	HYPH	denotes	-
T17659	30352-30353	CD	denotes	1
T17660	30357-30358	DT	denotes	a
T17661	30374-30381	NN	denotes	protein
T17662	30359-30363	NN	denotes	cold
T17663	30364-30373	JJ	denotes	inducible
T17664	30363-30364	HYPH	denotes	-
T17665	30382-30390	VBN	denotes	involved
T17666	30391-30393	IN	denotes	in
T17667	30394-30407	JJ	denotes	mitochondrial
T17668	30420-30430	NN	denotes	uncoupling
T17669	30408-30419	JJ	denotes	respiratory
T17670	30431-30433	TO	denotes	to
T17671	30434-30442	VB	denotes	generate
T17672	30443-30447	NN	denotes	heat
T17673	30448-30450	IN	denotes	in
T17674	30451-30454	NN	denotes	BAT
T17675	30454-30455	.	denotes	.
T17676	30455-30520	sentence	denotes	UCP-1 gene transcription is known to be activated by PGC-1α [2].
T17677	30456-30459	NN	denotes	UCP
T17678	30467-30480	NN	denotes	transcription
T17679	30459-30460	HYPH	denotes	-
T17680	30460-30461	CD	denotes	1
T17681	30462-30466	NN	denotes	gene
T17682	30484-30489	VBN	denotes	known
T17683	30481-30483	VBZ	denotes	is
T17684	30490-30492	TO	denotes	to
T17685	30496-30505	VBN	denotes	activated
T17686	30493-30495	VB	denotes	be
T17687	30506-30508	IN	denotes	by
T17688	30509-30512	NN	denotes	PGC
T17689	30513-30515	NN	denotes	1α
T17690	30512-30513	HYPH	denotes	-
T17691	30516-30517	-LRB-	denotes	[
T17692	30517-30518	CD	denotes	2
T17693	30518-30519	-RRB-	denotes	]
T17694	30519-30520	.	denotes	.
T17695	30520-30637	sentence	denotes	Surprisingly, basal and cold-induced BAT UCP-1 mRNA levels were similar in PGC-1α+/+ and PGC-1α−/− mice (Figure 6B).
T17696	30521-30533	RB	denotes	Surprisingly
T17697	30580-30584	VBD	denotes	were
T17698	30533-30535	,	denotes	,
T17699	30535-30540	JJ	denotes	basal
T17700	30573-30579	NNS	denotes	levels
T17701	30541-30544	CC	denotes	and
T17702	30545-30549	NN	denotes	cold
T17703	30550-30557	VBN	denotes	induced
T17704	30549-30550	HYPH	denotes	-
T17705	30558-30561	NN	denotes	BAT
T17706	30562-30565	NN	denotes	UCP
T17707	30565-30566	HYPH	denotes	-
T17708	30566-30567	CD	denotes	1
T17709	30568-30572	NN	denotes	mRNA
T17710	30585-30592	JJ	denotes	similar
T17711	30593-30595	IN	denotes	in
T17712	30596-30599	NN	denotes	PGC
T17713	30600-30602	NN	denotes	1α
T17714	30599-30600	HYPH	denotes	-
T17715	30620-30624	NNS	denotes	mice
T17716	30602-30603	SYM	denotes	+
T17717	30603-30604	HYPH	denotes	/
T17718	30604-30605	SYM	denotes	+
T17719	30606-30609	CC	denotes	and
T17720	30610-30613	NN	denotes	PGC
T17721	30614-30616	NN	denotes	1α
T17722	30613-30614	HYPH	denotes	-
T17723	30616-30617	SYM	denotes	−
T17724	30617-30618	HYPH	denotes	/
T17725	30618-30619	SYM	denotes	−
T17726	30625-30626	-LRB-	denotes	(
T17727	30633-30635	NN	denotes	6B
T17728	30626-30632	NN	denotes	Figure
T17729	30635-30636	-RRB-	denotes	)
T17730	30636-30637	.	denotes	.
T17731	30637-30911	sentence	denotes	These results suggest that PGC-1α is not necessary for the induction of the expression of UCP-1 with cold exposure, and that other factors, such as reduced capacity for mitochondrial respiration, likely contribute to the abnormal thermogenic response in the PGC-1α−/− mice.
T17732	30638-30643	DT	denotes	These
T17733	30644-30651	NNS	denotes	results
T17734	30652-30659	VBP	denotes	suggest
T17735	30660-30664	IN	denotes	that
T17736	30672-30674	VBZ	denotes	is
T17737	30665-30668	NN	denotes	PGC
T17738	30669-30671	NN	denotes	1α
T17739	30668-30669	HYPH	denotes	-
T17740	30675-30678	RB	denotes	not
T17741	30679-30688	JJ	denotes	necessary
T17742	30689-30692	IN	denotes	for
T17743	30693-30696	DT	denotes	the
T17744	30697-30706	NN	denotes	induction
T17745	30707-30709	IN	denotes	of
T17746	30710-30713	DT	denotes	the
T17747	30714-30724	NN	denotes	expression
T17748	30725-30727	IN	denotes	of
T17749	30728-30731	NN	denotes	UCP
T17750	30731-30732	HYPH	denotes	-
T17751	30732-30733	CD	denotes	1
T17752	30734-30738	IN	denotes	with
T17753	30739-30743	NN	denotes	cold
T17754	30744-30752	NN	denotes	exposure
T17755	30752-30754	,	denotes	,
T17756	30754-30757	CC	denotes	and
T17757	30758-30762	IN	denotes	that
T17758	30841-30851	VBP	denotes	contribute
T17759	30763-30768	JJ	denotes	other
T17760	30769-30776	NNS	denotes	factors
T17761	30776-30778	,	denotes	,
T17762	30778-30782	JJ	denotes	such
T17763	30783-30785	IN	denotes	as
T17764	30786-30793	VBN	denotes	reduced
T17765	30794-30802	NN	denotes	capacity
T17766	30803-30806	IN	denotes	for
T17767	30807-30820	JJ	denotes	mitochondrial
T17768	30821-30832	NN	denotes	respiration
T17769	30832-30834	,	denotes	,
T17770	30834-30840	RB	denotes	likely
T17771	30852-30854	IN	denotes	to
T17772	30855-30858	DT	denotes	the
T17773	30880-30888	NN	denotes	response
T17774	30859-30867	JJ	denotes	abnormal
T17775	30868-30879	JJ	denotes	thermogenic
T17776	30889-30891	IN	denotes	in
T17777	30892-30895	DT	denotes	the
T17778	30906-30910	NNS	denotes	mice
T17779	30896-30899	NN	denotes	PGC
T17780	30900-30902	NN	denotes	1α
T17781	30899-30900	HYPH	denotes	-
T17782	30902-30903	SYM	denotes	−
T17783	30903-30904	HYPH	denotes	/
T17784	30904-30905	SYM	denotes	−
T17785	30910-30911	.	denotes	.
T17786	30911-31038	sentence	denotes	Thermogenesis in rodents related to mitochondrial uncoupling is under the control of β3-adrenergic receptor coupled signaling.
T17787	30912-30925	NN	denotes	Thermogenesis
T17788	30973-30975	VBZ	denotes	is
T17789	30926-30928	IN	denotes	in
T17790	30929-30936	NNS	denotes	rodents
T17791	30937-30944	VBN	denotes	related
T17792	30945-30947	IN	denotes	to
T17793	30948-30961	JJ	denotes	mitochondrial
T17794	30962-30972	NN	denotes	uncoupling
T17795	30976-30981	IN	denotes	under
T17796	30982-30985	DT	denotes	the
T17797	30986-30993	NN	denotes	control
T17798	30994-30996	IN	denotes	of
T17799	30997-30999	NN	denotes	β3
T17800	31000-31010	JJ	denotes	adrenergic
T17801	30999-31000	HYPH	denotes	-
T17802	31011-31019	NN	denotes	receptor
T17803	31020-31027	VBN	denotes	coupled
T17804	31028-31037	NN	denotes	signaling
T17805	31037-31038	.	denotes	.
T17806	31038-31152	sentence	denotes	Accordingly, the in vivo oxygen consumption response to β3-adrenergic stimulation was examined in PGC-1α−/− mice.
T17807	31039-31050	RB	denotes	Accordingly
T17808	31125-31133	VBN	denotes	examined
T17809	31050-31052	,	denotes	,
T17810	31052-31055	DT	denotes	the
T17811	31083-31091	NN	denotes	response
T17812	31056-31058	FW	denotes	in
T17813	31059-31063	FW	denotes	vivo
T17814	31064-31070	NN	denotes	oxygen
T17815	31071-31082	NN	denotes	consumption
T17816	31092-31094	IN	denotes	to
T17817	31095-31097	NN	denotes	β3
T17818	31098-31108	JJ	denotes	adrenergic
T17819	31097-31098	HYPH	denotes	-
T17820	31109-31120	NN	denotes	stimulation
T17821	31121-31124	VBD	denotes	was
T17822	31134-31136	IN	denotes	in
T17823	31137-31140	NN	denotes	PGC
T17824	31141-31143	NN	denotes	1α
T17825	31140-31141	HYPH	denotes	-
T17826	31147-31151	NNS	denotes	mice
T17827	31143-31144	SYM	denotes	−
T17828	31144-31145	HYPH	denotes	/
T17829	31145-31146	SYM	denotes	−
T17830	31151-31152	.	denotes	.
T17831	31152-31294	sentence	denotes	For these experiments, VO2 (oxygen consumption) was measured following administration of the β3-agonist BRL 37344 using indirect calorimetry.
T17832	31153-31156	IN	denotes	For
T17833	31205-31213	VBN	denotes	measured
T17834	31157-31162	DT	denotes	these
T17835	31163-31174	NNS	denotes	experiments
T17836	31174-31176	,	denotes	,
T17837	31176-31179	NN	denotes	VO2
T17838	31180-31181	-LRB-	denotes	(
T17839	31181-31187	NN	denotes	oxygen
T17840	31188-31199	NN	denotes	consumption
T17841	31199-31200	-RRB-	denotes	)
T17842	31201-31204	VBD	denotes	was
T17843	31214-31223	VBG	denotes	following
T17844	31224-31238	NN	denotes	administration
T17845	31239-31241	IN	denotes	of
T17846	31242-31245	DT	denotes	the
T17847	31249-31256	NN	denotes	agonist
T17848	31246-31248	NN	denotes	β3
T17849	31248-31249	HYPH	denotes	-
T17850	31257-31260	NN	denotes	BRL
T17851	31261-31266	CD	denotes	37344
T17852	31267-31272	VBG	denotes	using
T17853	31273-31281	JJ	denotes	indirect
T17854	31282-31293	NN	denotes	calorimetry
T17855	31293-31294	.	denotes	.
T17856	31294-31399	sentence	denotes	VO2 was significantly increased in response to BRL 3744 in PGC-1α+/+ but not PGC-1α−/− mice (Figure 6C).
T17857	31295-31298	NN	denotes	VO2
T17858	31317-31326	VBN	denotes	increased
T17859	31299-31302	VBD	denotes	was
T17860	31303-31316	RB	denotes	significantly
T17861	31327-31329	IN	denotes	in
T17862	31330-31338	NN	denotes	response
T17863	31339-31341	IN	denotes	to
T17864	31342-31345	NN	denotes	BRL
T17865	31346-31350	CD	denotes	3744
T17866	31351-31353	IN	denotes	in
T17867	31354-31357	NN	denotes	PGC
T17868	31358-31360	NN	denotes	1α
T17869	31357-31358	HYPH	denotes	-
T17870	31382-31386	NNS	denotes	mice
T17871	31360-31361	SYM	denotes	+
T17872	31361-31362	HYPH	denotes	/
T17873	31362-31363	SYM	denotes	+
T17874	31364-31367	CC	denotes	but
T17875	31368-31371	RB	denotes	not
T17876	31372-31375	NN	denotes	PGC
T17877	31376-31378	NN	denotes	1α
T17878	31375-31376	HYPH	denotes	-
T17879	31378-31379	SYM	denotes	−
T17880	31379-31380	HYPH	denotes	/
T17881	31380-31381	SYM	denotes	−
T17882	31387-31388	-LRB-	denotes	(
T17883	31395-31397	NN	denotes	6C
T17884	31388-31394	NN	denotes	Figure
T17885	31397-31398	-RRB-	denotes	)
T17886	31398-31399	.	denotes	.
T17887	31399-31637	sentence	denotes	These results indicate that the metabolic response of BAT to an acute stimulus such as cold and/or β3-adrenergic stimulation is altered in the PGC-1α null mice, likely related to reduced capacity for mitochondrial respiratory uncoupling.
T17888	31400-31405	DT	denotes	These
T17889	31406-31413	NNS	denotes	results
T17890	31414-31422	VBP	denotes	indicate
T17891	31423-31427	IN	denotes	that
T17892	31528-31535	VBN	denotes	altered
T17893	31428-31431	DT	denotes	the
T17894	31442-31450	NN	denotes	response
T17895	31432-31441	JJ	denotes	metabolic
T17896	31451-31453	IN	denotes	of
T17897	31454-31457	NN	denotes	BAT
T17898	31458-31460	IN	denotes	to
T17899	31461-31463	DT	denotes	an
T17900	31470-31478	NN	denotes	stimulus
T17901	31464-31469	JJ	denotes	acute
T17902	31479-31483	JJ	denotes	such
T17903	31484-31486	IN	denotes	as
T17904	31487-31491	JJ	denotes	cold
T17905	31513-31524	NN	denotes	stimulation
T17906	31492-31495	CC	denotes	and
T17907	31495-31496	HYPH	denotes	/
T17908	31496-31498	CC	denotes	or
T17909	31499-31501	NN	denotes	β3
T17910	31502-31512	JJ	denotes	adrenergic
T17911	31501-31502	HYPH	denotes	-
T17912	31525-31527	VBZ	denotes	is
T17913	31536-31538	IN	denotes	in
T17914	31539-31542	DT	denotes	the
T17915	31555-31559	NNS	denotes	mice
T17916	31543-31546	NN	denotes	PGC
T17917	31547-31549	NN	denotes	1α
T17918	31546-31547	HYPH	denotes	-
T17919	31550-31554	JJ	denotes	null
T17920	31559-31561	,	denotes	,
T17921	31561-31567	RB	denotes	likely
T17922	31568-31575	VBN	denotes	related
T17923	31576-31578	IN	denotes	to
T17924	31579-31586	VBN	denotes	reduced
T17925	31587-31595	NN	denotes	capacity
T17926	31596-31599	IN	denotes	for
T17927	31600-31613	JJ	denotes	mitochondrial
T17928	31626-31636	NN	denotes	uncoupling
T17929	31614-31625	JJ	denotes	respiratory
T17930	31636-31637	.	denotes	.
T20245	31639-31646	NN	denotes	Fasting
T20246	31647-31654	VBN	denotes	Induced
T20247	31646-31647	HYPH	denotes	-
T20248	31663-31672	NN	denotes	Steatosis
T20249	31655-31662	JJ	denotes	Hepatic
T20250	31673-31675	IN	denotes	in
T20251	31676-31679	NN	denotes	PGC
T20252	31680-31682	NN	denotes	1α
T20253	31679-31680	HYPH	denotes	-
T20254	31686-31690	NNS	denotes	Mice
T20255	31682-31683	SYM	denotes	−
T20256	31683-31684	HYPH	denotes	/
T20257	31684-31685	SYM	denotes	−
T20258	31690-31835	sentence	denotes	Previous studies have implicated PGC-1α in several hepatic metabolic functions including fatty acid oxidation and gluconeogenesis [18,19,20,21].
T20259	31691-31699	JJ	denotes	Previous
T20260	31700-31707	NNS	denotes	studies
T20261	31713-31723	VBN	denotes	implicated
T20262	31708-31712	VBP	denotes	have
T20263	31724-31727	NN	denotes	PGC
T20264	31728-31730	NN	denotes	1α
T20265	31727-31728	HYPH	denotes	-
T20266	31731-31733	IN	denotes	in
T20267	31734-31741	JJ	denotes	several
T20268	31760-31769	NNS	denotes	functions
T20269	31742-31749	JJ	denotes	hepatic
T20270	31750-31759	JJ	denotes	metabolic
T20271	31770-31779	VBG	denotes	including
T20272	31780-31785	JJ	denotes	fatty
T20273	31786-31790	NN	denotes	acid
T20274	31791-31800	NN	denotes	oxidation
T20275	31801-31804	CC	denotes	and
T20276	31805-31820	NN	denotes	gluconeogenesis
T20277	31821-31822	-LRB-	denotes	[
T20278	31831-31833	CD	denotes	21
T20279	31822-31824	CD	denotes	18
T20280	31824-31825	,	denotes	,
T20281	31825-31827	CD	denotes	19
T20282	31827-31828	,	denotes	,
T20283	31828-31830	CD	denotes	20
T20284	31830-31831	,	denotes	,
T20285	31833-31834	-RRB-	denotes	]
T20286	31834-31835	.	denotes	.
T20287	31835-32016	sentence	denotes	Accordingly, the hepatic phenotype was evaluated under basal conditions and following a 24-h fast, a stimulus known to induce fatty acid oxidation and gluconeogenic rates in liver.
T20288	31836-31847	RB	denotes	Accordingly
T20289	31875-31884	VBN	denotes	evaluated
T20290	31847-31849	,	denotes	,
T20291	31849-31852	DT	denotes	the
T20292	31861-31870	NN	denotes	phenotype
T20293	31853-31860	JJ	denotes	hepatic
T20294	31871-31874	VBD	denotes	was
T20295	31885-31890	IN	denotes	under
T20296	31891-31896	JJ	denotes	basal
T20297	31897-31907	NNS	denotes	conditions
T20298	31908-31911	CC	denotes	and
T20299	31912-31921	VBG	denotes	following
T20300	31922-31923	DT	denotes	a
T20301	31929-31933	NN	denotes	fast
T20302	31924-31926	CD	denotes	24
T20303	31927-31928	NN	denotes	h
T20304	31926-31927	HYPH	denotes	-
T20305	31933-31935	,	denotes	,
T20306	31935-31936	DT	denotes	a
T20307	31937-31945	NN	denotes	stimulus
T20308	31946-31951	VBN	denotes	known
T20309	31952-31954	TO	denotes	to
T20310	31955-31961	VB	denotes	induce
T20311	31962-31967	JJ	denotes	fatty
T20312	31968-31972	NN	denotes	acid
T20313	31973-31982	NN	denotes	oxidation
T20314	31983-31986	CC	denotes	and
T20315	31987-32000	JJ	denotes	gluconeogenic
T20316	32001-32006	NNS	denotes	rates
T20317	32007-32009	IN	denotes	in
T20318	32010-32015	NN	denotes	liver
T20319	32015-32016	.	denotes	.
T20320	32016-32166	sentence	denotes	Under basal fed conditions, the livers of the PGC-1α−/− mice appeared grossly normal and did not exhibit histologic abnormalities (unpublished data).
T20321	32017-32022	IN	denotes	Under
T20322	32078-32086	VBD	denotes	appeared
T20323	32023-32028	JJ	denotes	basal
T20324	32033-32043	NNS	denotes	conditions
T20325	32029-32032	VBN	denotes	fed
T20326	32043-32045	,	denotes	,
T20327	32045-32048	DT	denotes	the
T20328	32049-32055	NNS	denotes	livers
T20329	32056-32058	IN	denotes	of
T20330	32059-32062	DT	denotes	the
T20331	32073-32077	NNS	denotes	mice
T20332	32063-32066	NN	denotes	PGC
T20333	32067-32069	NN	denotes	1α
T20334	32066-32067	HYPH	denotes	-
T20335	32069-32070	SYM	denotes	−
T20336	32070-32071	HYPH	denotes	/
T20337	32071-32072	SYM	denotes	−
T20338	32087-32094	RB	denotes	grossly
T20339	32095-32101	JJ	denotes	normal
T20340	32102-32105	CC	denotes	and
T20341	32106-32109	VBD	denotes	did
T20342	32114-32121	VB	denotes	exhibit
T20343	32110-32113	RB	denotes	not
T20344	32122-32132	JJ	denotes	histologic
T20345	32133-32146	NNS	denotes	abnormalities
T20346	32147-32148	-LRB-	denotes	(
T20347	32160-32164	NNS	denotes	data
T20348	32148-32159	JJ	denotes	unpublished
T20349	32164-32165	-RRB-	denotes	)
T20350	32165-32166	.	denotes	.
T20351	32166-32392	sentence	denotes	However, following a 24 h-fast, the PGC-1α−/− mice exhibited marked hepatic steatosis as determined by gross inspection, oil red O staining, electron microscopy, and measurements of liver triglyceride (TAG) levels (Figure 7).
T20352	32167-32174	RB	denotes	However
T20353	32218-32227	VBD	denotes	exhibited
T20354	32174-32176	,	denotes	,
T20355	32176-32185	VBG	denotes	following
T20356	32186-32187	DT	denotes	a
T20357	32193-32197	NN	denotes	fast
T20358	32188-32190	CD	denotes	24
T20359	32191-32192	NN	denotes	h
T20360	32192-32193	HYPH	denotes	-
T20361	32197-32199	,	denotes	,
T20362	32199-32202	DT	denotes	the
T20363	32213-32217	NNS	denotes	mice
T20364	32203-32206	NN	denotes	PGC
T20365	32207-32209	NN	denotes	1α
T20366	32206-32207	HYPH	denotes	-
T20367	32209-32210	SYM	denotes	−
T20368	32210-32211	HYPH	denotes	/
T20369	32211-32212	SYM	denotes	−
T20370	32228-32234	JJ	denotes	marked
T20371	32243-32252	NN	denotes	steatosis
T20372	32235-32242	JJ	denotes	hepatic
T20373	32253-32255	IN	denotes	as
T20374	32256-32266	VBN	denotes	determined
T20375	32267-32269	IN	denotes	by
T20376	32270-32275	JJ	denotes	gross
T20377	32276-32286	NN	denotes	inspection
T20378	32286-32288	,	denotes	,
T20379	32288-32291	NN	denotes	oil
T20380	32296-32297	NN	denotes	O
T20381	32292-32295	JJ	denotes	red
T20382	32298-32306	NN	denotes	staining
T20383	32306-32308	,	denotes	,
T20384	32308-32316	NN	denotes	electron
T20385	32317-32327	NN	denotes	microscopy
T20386	32327-32329	,	denotes	,
T20387	32329-32332	CC	denotes	and
T20388	32333-32345	NNS	denotes	measurements
T20389	32346-32348	IN	denotes	of
T20390	32349-32354	NN	denotes	liver
T20391	32374-32380	NNS	denotes	levels
T20392	32355-32367	NN	denotes	triglyceride
T20393	32368-32369	-LRB-	denotes	(
T20394	32369-32372	NN	denotes	TAG
T20395	32372-32373	-RRB-	denotes	)
T20396	32381-32382	-LRB-	denotes	(
T20397	32382-32388	NN	denotes	Figure
T20398	32389-32390	CD	denotes	7
T20399	32390-32391	-RRB-	denotes	)
T20400	32391-32392	.	denotes	.
T20401	32392-32528	sentence	denotes	There were no differences in plasma triglycerides or free fatty acids between the genotypes in fed or fasted states (unpublished data).
T20402	32393-32398	EX	denotes	There
T20403	32399-32403	VBD	denotes	were
T20404	32404-32406	DT	denotes	no
T20405	32407-32418	NNS	denotes	differences
T20406	32419-32421	IN	denotes	in
T20407	32422-32428	NN	denotes	plasma
T20408	32429-32442	NNS	denotes	triglycerides
T20409	32443-32445	CC	denotes	or
T20410	32446-32450	JJ	denotes	free
T20411	32457-32462	NNS	denotes	acids
T20412	32451-32456	JJ	denotes	fatty
T20413	32463-32470	IN	denotes	between
T20414	32471-32474	DT	denotes	the
T20415	32475-32484	NNS	denotes	genotypes
T20416	32485-32487	IN	denotes	in
T20417	32488-32491	VBN	denotes	fed
T20418	32502-32508	NNS	denotes	states
T20419	32492-32494	CC	denotes	or
T20420	32495-32501	VBN	denotes	fasted
T20421	32509-32510	-LRB-	denotes	(
T20422	32522-32526	NNS	denotes	data
T20423	32510-32521	JJ	denotes	unpublished
T20424	32526-32527	-RRB-	denotes	)
T20425	32527-32528	.	denotes	.
T20426	32528-32689	sentence	denotes	To further investigate the mechanisms involved in the fasting-induced hepatic steatotic response, hepatocytes were isolated from PGC-1α−/− mice and WT controls.
T20427	32529-32531	TO	denotes	To
T20428	32540-32551	VB	denotes	investigate
T20429	32532-32539	RB	denotes	further
T20430	32644-32652	VBN	denotes	isolated
T20431	32552-32555	DT	denotes	the
T20432	32556-32566	NNS	denotes	mechanisms
T20433	32567-32575	VBN	denotes	involved
T20434	32576-32578	IN	denotes	in
T20435	32579-32582	DT	denotes	the
T20436	32617-32625	NN	denotes	response
T20437	32583-32590	NN	denotes	fasting
T20438	32591-32598	VBN	denotes	induced
T20439	32590-32591	HYPH	denotes	-
T20440	32599-32606	JJ	denotes	hepatic
T20441	32607-32616	JJ	denotes	steatotic
T20442	32625-32627	,	denotes	,
T20443	32627-32638	NNS	denotes	hepatocytes
T20444	32639-32643	VBD	denotes	were
T20445	32653-32657	IN	denotes	from
T20446	32658-32661	NN	denotes	PGC
T20447	32662-32664	NN	denotes	1α
T20448	32661-32662	HYPH	denotes	-
T20449	32668-32672	NNS	denotes	mice
T20450	32664-32665	SYM	denotes	−
T20451	32665-32666	HYPH	denotes	/
T20452	32666-32667	SYM	denotes	−
T20453	32673-32676	CC	denotes	and
T20454	32677-32679	NN	denotes	WT
T20455	32680-32688	NNS	denotes	controls
T20456	32688-32689	.	denotes	.
T20457	32689-32847	sentence	denotes	Oleate loading experiments revealed that the PGC-1α−/− hepatocytes accumulated neutral lipid to a significantly greater extent than the WT cells (Figure 8A).
T20458	32690-32696	NN	denotes	Oleate
T20459	32697-32704	NN	denotes	loading
T20460	32705-32716	NNS	denotes	experiments
T20461	32717-32725	VBD	denotes	revealed
T20462	32726-32730	IN	denotes	that
T20463	32757-32768	VBD	denotes	accumulated
T20464	32731-32734	DT	denotes	the
T20465	32745-32756	NNS	denotes	hepatocytes
T20466	32735-32738	NN	denotes	PGC
T20467	32739-32741	NN	denotes	1α
T20468	32738-32739	HYPH	denotes	-
T20469	32741-32742	SYM	denotes	−
T20470	32742-32743	HYPH	denotes	/
T20471	32743-32744	SYM	denotes	−
T20472	32769-32776	JJ	denotes	neutral
T20473	32777-32782	NN	denotes	lipid
T20474	32783-32785	IN	denotes	to
T20475	32786-32787	DT	denotes	a
T20476	32810-32816	NN	denotes	extent
T20477	32788-32801	RB	denotes	significantly
T20478	32802-32809	JJR	denotes	greater
T20479	32817-32821	IN	denotes	than
T20480	32822-32825	DT	denotes	the
T20481	32829-32834	NNS	denotes	cells
T20482	32826-32828	NN	denotes	WT
T20483	32835-32836	-LRB-	denotes	(
T20484	32843-32845	NN	denotes	8A
T20485	32836-32842	NN	denotes	Figure
T20486	32845-32846	-RRB-	denotes	)
T20487	32846-32847	.	denotes	.
T20488	32847-33029	sentence	denotes	3H-palmitate oxidation rates were significantly lower in PGC-1α−/− hepatocytes compared to PGC-1α+/+ hepatocytes under basal conditions and following exposure to oleate (Figure 8B).
T20489	32848-32850	NN	denotes	3H
T20490	32851-32860	NN	denotes	palmitate
T20491	32850-32851	HYPH	denotes	-
T20492	32861-32870	NN	denotes	oxidation
T20493	32871-32876	NNS	denotes	rates
T20494	32877-32881	VBD	denotes	were
T20495	32882-32895	RB	denotes	significantly
T20496	32896-32901	JJR	denotes	lower
T20497	32902-32904	IN	denotes	in
T20498	32905-32908	NN	denotes	PGC
T20499	32909-32911	NN	denotes	1α
T20500	32908-32909	HYPH	denotes	-
T20501	32915-32926	NNS	denotes	hepatocytes
T20502	32911-32912	SYM	denotes	−
T20503	32912-32913	HYPH	denotes	/
T20504	32913-32914	SYM	denotes	−
T20505	32927-32935	VBN	denotes	compared
T20506	32936-32938	IN	denotes	to
T20507	32939-32942	NN	denotes	PGC
T20508	32943-32945	NN	denotes	1α
T20509	32942-32943	HYPH	denotes	-
T20510	32949-32960	NNS	denotes	hepatocytes
T20511	32945-32946	SYM	denotes	+
T20512	32946-32947	HYPH	denotes	/
T20513	32947-32948	SYM	denotes	+
T20514	32961-32966	IN	denotes	under
T20515	32967-32972	JJ	denotes	basal
T20516	32973-32983	NNS	denotes	conditions
T20517	32984-32987	CC	denotes	and
T20518	32988-32997	IN	denotes	following
T20519	32998-33006	NN	denotes	exposure
T20520	33007-33009	IN	denotes	to
T20521	33010-33016	NN	denotes	oleate
T20522	33017-33018	-LRB-	denotes	(
T20523	33025-33027	NN	denotes	8B
T20524	33018-33024	NN	denotes	Figure
T20525	33027-33028	-RRB-	denotes	)
T20526	33028-33029	.	denotes	.
T20527	33029-33264	sentence	denotes	Taken together, these latter results indicate a cell-autonomous defect in PGC-1α−/− hepatocytes that results in an inability to maintain cellular lipid balance in the context of increased delivery of lipid such as occurs with fasting.
T20528	33030-33035	VBN	denotes	Taken
T20529	33067-33075	VBP	denotes	indicate
T20530	33036-33044	RB	denotes	together
T20531	33044-33046	,	denotes	,
T20532	33046-33051	DT	denotes	these
T20533	33059-33066	NNS	denotes	results
T20534	33052-33058	JJ	denotes	latter
T20535	33076-33077	DT	denotes	a
T20536	33094-33100	NN	denotes	defect
T20537	33078-33082	NN	denotes	cell
T20538	33083-33093	JJ	denotes	autonomous
T20539	33082-33083	HYPH	denotes	-
T20540	33101-33103	IN	denotes	in
T20541	33104-33107	NN	denotes	PGC
T20542	33108-33110	NN	denotes	1α
T20543	33107-33108	HYPH	denotes	-
T20544	33114-33125	NNS	denotes	hepatocytes
T20545	33110-33111	SYM	denotes	−
T20546	33111-33112	HYPH	denotes	/
T20547	33112-33113	SYM	denotes	−
T20548	33126-33130	WDT	denotes	that
T20549	33131-33138	VBZ	denotes	results
T20550	33139-33141	IN	denotes	in
T20551	33142-33144	DT	denotes	an
T20552	33145-33154	NN	denotes	inability
T20553	33155-33157	TO	denotes	to
T20554	33158-33166	VB	denotes	maintain
T20555	33167-33175	JJ	denotes	cellular
T20556	33182-33189	NN	denotes	balance
T20557	33176-33181	NN	denotes	lipid
T20558	33190-33192	IN	denotes	in
T20559	33193-33196	DT	denotes	the
T20560	33197-33204	NN	denotes	context
T20561	33205-33207	IN	denotes	of
T20562	33208-33217	VBN	denotes	increased
T20563	33218-33226	NN	denotes	delivery
T20564	33227-33229	IN	denotes	of
T20565	33230-33235	NN	denotes	lipid
T20566	33236-33240	JJ	denotes	such
T20567	33241-33243	IN	denotes	as
T20568	33244-33250	VBZ	denotes	occurs
T20569	33251-33255	IN	denotes	with
T20570	33256-33263	NN	denotes	fasting
T20571	33263-33264	.	denotes	.
T20572	33264-35278	sentence	denotes	Figure 7 Fasting-Induced Hepatic Steatosis Develops in PGC-1α−/− Mice (A) The photograph depicts the development of a pale liver in PGC-1α−/− mice subjected to a 24-h fast. (B) Oil red O staining of histologic sections of liver taken from PGC-1α−/− mice under fed and 24 h fasted conditions. The red staining indicates neutral lipid. (C) Representative electron micrographs of the liver from PGC-1α+/+ and PGC-1α−/− mice following a 24-h fast. The droplets are indicative of neutral lipid accumulation. (D) Mean liver TAG levels in PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) mice under fed and 24-h fasted conditions. * p < 0.05. Figure 8 Hepatocytes Isolated from PGC-1α−/− Mice Exhibit Reduced Oxidative Capacity (A) Oil red O staining of isolated hepatocytes exposed to BSA alone (BSA) or 50 μM oleate complexed to BSA (oleate). (B) 3H-palmitate oxidation rates. 3H-palmitate oxidation rates determined in hepatocytes isolated from PGC-1α+/+ and PGC-1α−/− mice under cell culture conditions containing BSA or BSA + 50 μM oleate (2:1 oleate/BSA ratio). Values were derived from ten sets of triplicates for each group using hepatocytes from 5 mice of each genotype. The bars represent mean oxidation rates (n = 100) normalized to the condition of PGC-1α+/+ in BSA alone. * p < 0.05 compared to the corresponding PGC-1α+/+ mice. † p < 0.05 compared to PGC-1α+/+ with BSA treatment. (C) State 2 and 3 respiration rates determined for hepatocytes isolated from PGC-1α+/+ (n = 3) and PGC-1α−/− (n = 3) mice using succinate/rotenone as a substrate. * p < 0.05 compared to corresponding PGC-1α+/+. (D) TAG synthesis rates in isolated hepatocytes. The bars represent mean TAG synthesis rates (glycerol incorporation, see Materials and Methods) for hepatocytes isolated from PGC-1α+/+ (n = 6) and PGC-1α−/− (n = 6) mice. * p < 0.05 compared to the corresponding PGC-1α+/+ condition. PPAR, a known regulator of hepatic mitochondrial fatty acid oxidation enzyme gene expression, is a target for coactivation by PGC-1α [31].
T20573	35140-35144	NN	denotes	PPAR
T20574	35234-35236	VBZ	denotes	is
T20575	35144-35146	,	denotes	,
T20576	35146-35147	DT	denotes	a
T20577	35154-35163	NN	denotes	regulator
T20578	35148-35153	JJ	denotes	known
T20579	35164-35166	IN	denotes	of
T20580	35167-35174	JJ	denotes	hepatic
T20581	35210-35216	NN	denotes	enzyme
T20582	35175-35188	JJ	denotes	mitochondrial
T20583	35189-35194	JJ	denotes	fatty
T20584	35195-35199	NN	denotes	acid
T20585	35200-35209	NN	denotes	oxidation
T20586	35222-35232	NN	denotes	expression
T20587	35217-35221	NN	denotes	gene
T20588	35232-35234	,	denotes	,
T20589	35237-35238	DT	denotes	a
T20590	35239-35245	NN	denotes	target
T20591	35246-35249	IN	denotes	for
T20592	35250-35262	NN	denotes	coactivation
T20593	35263-35265	IN	denotes	by
T20594	35266-35269	NN	denotes	PGC
T20595	35270-35272	NN	denotes	1α
T20596	35269-35270	HYPH	denotes	-
T20597	35273-35274	-LRB-	denotes	[
T20598	35274-35276	CD	denotes	31
T20599	35276-35277	-RRB-	denotes	]
T20600	35277-35278	.	denotes	.
T20601	35278-35418	sentence	denotes	Therefore, we sought to determine whether the steatotic phenotype of the PGC-1α−/− mice related to reduced expression of PPAR target genes.
T20602	35279-35288	RB	denotes	Therefore
T20603	35293-35299	VBD	denotes	sought
T20604	35288-35290	,	denotes	,
T20605	35290-35292	PRP	denotes	we
T20606	35300-35302	TO	denotes	to
T20607	35303-35312	VB	denotes	determine
T20608	35313-35320	IN	denotes	whether
T20609	35367-35374	VBN	denotes	related
T20610	35321-35324	DT	denotes	the
T20611	35335-35344	NN	denotes	phenotype
T20612	35325-35334	JJ	denotes	steatotic
T20613	35345-35347	IN	denotes	of
T20614	35348-35351	DT	denotes	the
T20615	35362-35366	NNS	denotes	mice
T20616	35352-35355	NN	denotes	PGC
T20617	35356-35358	NN	denotes	1α
T20618	35355-35356	HYPH	denotes	-
T20619	35358-35359	SYM	denotes	−
T20620	35359-35360	HYPH	denotes	/
T20621	35360-35361	SYM	denotes	−
T20622	35375-35377	IN	denotes	to
T20623	35378-35385	VBN	denotes	reduced
T20624	35386-35396	NN	denotes	expression
T20625	35397-35399	IN	denotes	of
T20626	35400-35404	NN	denotes	PPAR
T20627	35412-35417	NNS	denotes	genes
T20628	35405-35411	NN	denotes	target
T20629	35417-35418	.	denotes	.
T20630	35418-35517	sentence	denotes	To this end, a survey of candidate genes and gene expression profiling experiments were performed.
T20631	35419-35421	IN	denotes	To
T20632	35507-35516	VBN	denotes	performed
T20633	35422-35426	DT	denotes	this
T20634	35427-35430	NN	denotes	end
T20635	35430-35432	,	denotes	,
T20636	35432-35433	DT	denotes	a
T20637	35434-35440	NN	denotes	survey
T20638	35441-35443	IN	denotes	of
T20639	35444-35453	NN	denotes	candidate
T20640	35454-35459	NNS	denotes	genes
T20641	35460-35463	CC	denotes	and
T20642	35464-35468	NN	denotes	gene
T20643	35469-35479	NN	denotes	expression
T20644	35480-35489	NN	denotes	profiling
T20645	35490-35501	NNS	denotes	experiments
T20646	35502-35506	VBD	denotes	were
T20647	35516-35517	.	denotes	.
T20648	35517-35734	sentence	denotes	Surprisingly, the hepatic expression of PPAR target genes involved in cellular fatty acid and oxidation (MCPT and MCAD) were not significantly different between the genotypes under fed or fasted conditions (Table 2).
T20649	35518-35530	RB	denotes	Surprisingly
T20650	35638-35642	VBD	denotes	were
T20651	35530-35532	,	denotes	,
T20652	35532-35535	DT	denotes	the
T20653	35544-35554	NN	denotes	expression
T20654	35536-35543	JJ	denotes	hepatic
T20655	35555-35557	IN	denotes	of
T20656	35558-35562	NN	denotes	PPAR
T20657	35570-35575	NNS	denotes	genes
T20658	35563-35569	NN	denotes	target
T20659	35576-35584	VBN	denotes	involved
T20660	35585-35587	IN	denotes	in
T20661	35588-35596	JJ	denotes	cellular
T20662	35603-35607	NN	denotes	acid
T20663	35597-35602	JJ	denotes	fatty
T20664	35608-35611	CC	denotes	and
T20665	35612-35621	NN	denotes	oxidation
T20666	35622-35623	-LRB-	denotes	(
T20667	35623-35627	NN	denotes	MCPT
T20668	35628-35631	CC	denotes	and
T20669	35632-35636	NN	denotes	MCAD
T20670	35636-35637	-RRB-	denotes	)
T20671	35643-35646	RB	denotes	not
T20672	35647-35660	RB	denotes	significantly
T20673	35661-35670	JJ	denotes	different
T20674	35671-35678	IN	denotes	between
T20675	35679-35682	DT	denotes	the
T20676	35683-35692	NNS	denotes	genotypes
T20677	35693-35698	IN	denotes	under
T20678	35699-35702	VBN	denotes	fed
T20679	35713-35723	NNS	denotes	conditions
T20680	35703-35705	CC	denotes	or
T20681	35706-35712	VBN	denotes	fasted
T20682	35724-35725	-LRB-	denotes	(
T20683	35725-35730	NN	denotes	Table
T20684	35731-35732	CD	denotes	2
T20685	35732-35733	-RRB-	denotes	)
T20686	35733-35734	.	denotes	.
T20687	35734-35925	sentence	denotes	Next, we performed experiments to determine whether the reduced capacity for fat oxidation in the hepatocytes of the PGC-1α−/− mice was related to altered mitochondrial respiratory function.
T20688	35735-35739	RB	denotes	Next
T20689	35744-35753	VBD	denotes	performed
T20690	35739-35741	,	denotes	,
T20691	35741-35743	PRP	denotes	we
T20692	35754-35765	NNS	denotes	experiments
T20693	35766-35768	TO	denotes	to
T20694	35769-35778	VB	denotes	determine
T20695	35779-35786	IN	denotes	whether
T20696	35871-35878	VBN	denotes	related
T20697	35787-35790	DT	denotes	the
T20698	35799-35807	NN	denotes	capacity
T20699	35791-35798	VBN	denotes	reduced
T20700	35808-35811	IN	denotes	for
T20701	35812-35815	NN	denotes	fat
T20702	35816-35825	NN	denotes	oxidation
T20703	35826-35828	IN	denotes	in
T20704	35829-35832	DT	denotes	the
T20705	35833-35844	NNS	denotes	hepatocytes
T20706	35845-35847	IN	denotes	of
T20707	35848-35851	DT	denotes	the
T20708	35862-35866	NNS	denotes	mice
T20709	35852-35855	NN	denotes	PGC
T20710	35856-35858	NN	denotes	1α
T20711	35855-35856	HYPH	denotes	-
T20712	35858-35859	SYM	denotes	−
T20713	35859-35860	HYPH	denotes	/
T20714	35860-35861	SYM	denotes	−
T20715	35867-35870	VBD	denotes	was
T20716	35879-35881	IN	denotes	to
T20717	35882-35889	JJ	denotes	altered
T20718	35916-35924	NN	denotes	function
T20719	35890-35903	JJ	denotes	mitochondrial
T20720	35904-35915	JJ	denotes	respiratory
T20721	35924-35925	.	denotes	.
T20722	35925-36080	sentence	denotes	Compared to the WT controls, PGC-1α−/− hepatocytes exhibited a modest but significant reduction in both state 2 and state 3 respiration rates (Figure 8C).
T20723	35926-35934	VBN	denotes	Compared
T20724	35977-35986	VBD	denotes	exhibited
T20725	35935-35937	IN	denotes	to
T20726	35938-35941	DT	denotes	the
T20727	35945-35953	NNS	denotes	controls
T20728	35942-35944	NN	denotes	WT
T20729	35953-35955	,	denotes	,
T20730	35955-35958	NN	denotes	PGC
T20731	35959-35961	NN	denotes	1α
T20732	35958-35959	HYPH	denotes	-
T20733	35965-35976	NNS	denotes	hepatocytes
T20734	35961-35962	SYM	denotes	−
T20735	35962-35963	HYPH	denotes	/
T20736	35963-35964	SYM	denotes	−
T20737	35987-35988	DT	denotes	a
T20738	36012-36021	NN	denotes	reduction
T20739	35989-35995	JJ	denotes	modest
T20740	35996-35999	CC	denotes	but
T20741	36000-36011	JJ	denotes	significant
T20742	36022-36024	IN	denotes	in
T20743	36025-36029	CC	denotes	both
T20744	36030-36035	NN	denotes	state
T20745	36062-36067	NNS	denotes	rates
T20746	36036-36037	CD	denotes	2
T20747	36038-36041	CC	denotes	and
T20748	36042-36047	NN	denotes	state
T20749	36048-36049	CD	denotes	3
T20750	36050-36061	NN	denotes	respiration
T20751	36068-36069	-LRB-	denotes	(
T20752	36076-36078	NN	denotes	8C
T20753	36069-36075	NN	denotes	Figure
T20754	36078-36079	-RRB-	denotes	)
T20755	36079-36080	.	denotes	.
T20756	36080-36263	sentence	denotes	These results identify one potential mechanism responsible for the fasting-induced hepatic steatosis: reduced capacity for fat oxidation due to mitochondrial respiratory dysfunction.
T20757	36081-36086	DT	denotes	These
T20758	36087-36094	NNS	denotes	results
T20759	36095-36103	VBP	denotes	identify
T20760	36104-36107	CD	denotes	one
T20761	36118-36127	NN	denotes	mechanism
T20762	36108-36117	JJ	denotes	potential
T20763	36128-36139	JJ	denotes	responsible
T20764	36140-36143	IN	denotes	for
T20765	36144-36147	DT	denotes	the
T20766	36172-36181	NN	denotes	steatosis
T20767	36148-36155	NN	denotes	fasting
T20768	36156-36163	VBN	denotes	induced
T20769	36155-36156	HYPH	denotes	-
T20770	36164-36171	JJ	denotes	hepatic
T20771	36181-36183	:	denotes	:
T20772	36183-36190	VBN	denotes	reduced
T20773	36191-36199	NN	denotes	capacity
T20774	36200-36203	IN	denotes	for
T20775	36204-36207	NN	denotes	fat
T20776	36208-36217	NN	denotes	oxidation
T20777	36218-36221	IN	denotes	due
T20778	36222-36224	IN	denotes	to
T20779	36225-36238	JJ	denotes	mitochondrial
T20780	36251-36262	NN	denotes	dysfunction
T20781	36239-36250	JJ	denotes	respiratory
T20782	36262-36263	.	denotes	.
T20783	36263-37217	sentence	denotes	Table 2 Metabolic Gene Expression in Liver of Fed and Fasted PGC-1α+/+ and PGC-1α−/− Mice Values represent mean (± SEM) (n ≥ 6 for each group) mRNA levels as determined by real-time RT-PCR corrected for GAPDH signal intensity and normalized (to 1.0) to the value of fed PGC-1α+/+ mice a p < 0.05 versus fed mice of the same genotype b p < 0.05 versus PGC-1α+/+ mice of the same dietary treatment L-CPT I, liver-type carnitine palmitoyltransferase; MCAD, medium-chain acyl-CoA dehydrogenase; SREBP, sterol regulatory element binding protein; SCD, steroyl-CoA desaturase; FAS, fatty acid synthase; GPAT, glycerol-3-phosphate acyltransferase; DGAT, diacylglycerol acyltransferase Although the liver gene expression profiling studies did not reveal abnormalities in the fatty acid oxidation pathway in the PGC-1α−/− mice, several interesting differences in the activity of the sterol regulatory element binding protein-1c (SREBP-1c) pathway were noted.
T20784	36946-36954	IN	denotes	Although
T20785	37007-37013	VB	denotes	reveal
T20786	36955-36958	DT	denotes	the
T20787	36991-36998	NNS	denotes	studies
T20788	36959-36964	NN	denotes	liver
T20789	36965-36969	NN	denotes	gene
T20790	36981-36990	NN	denotes	profiling
T20791	36970-36980	NN	denotes	expression
T20792	36999-37002	VBD	denotes	did
T20793	37003-37006	RB	denotes	not
T20794	37211-37216	VBN	denotes	noted
T20795	37014-37027	NNS	denotes	abnormalities
T20796	37028-37030	IN	denotes	in
T20797	37031-37034	DT	denotes	the
T20798	37056-37063	NN	denotes	pathway
T20799	37035-37040	JJ	denotes	fatty
T20800	37041-37045	NN	denotes	acid
T20801	37046-37055	NN	denotes	oxidation
T20802	37064-37066	IN	denotes	in
T20803	37067-37070	DT	denotes	the
T20804	37081-37085	NNS	denotes	mice
T20805	37071-37074	NN	denotes	PGC
T20806	37075-37077	NN	denotes	1α
T20807	37074-37075	HYPH	denotes	-
T20808	37077-37078	SYM	denotes	−
T20809	37078-37079	HYPH	denotes	/
T20810	37079-37080	SYM	denotes	−
T20811	37085-37087	,	denotes	,
T20812	37087-37094	JJ	denotes	several
T20813	37107-37118	NNS	denotes	differences
T20814	37095-37106	JJ	denotes	interesting
T20815	37119-37121	IN	denotes	in
T20816	37122-37125	DT	denotes	the
T20817	37126-37134	NN	denotes	activity
T20818	37135-37137	IN	denotes	of
T20819	37138-37141	DT	denotes	the
T20820	37198-37205	NN	denotes	pathway
T20821	37142-37148	NN	denotes	sterol
T20822	37176-37183	NN	denotes	protein
T20823	37149-37159	JJ	denotes	regulatory
T20824	37160-37167	NN	denotes	element
T20825	37168-37175	NN	denotes	binding
T20826	37184-37186	NN	denotes	1c
T20827	37183-37184	HYPH	denotes	-
T20828	37187-37188	-LRB-	denotes	(
T20829	37188-37193	NN	denotes	SREBP
T20830	37194-37196	NN	denotes	1c
T20831	37193-37194	HYPH	denotes	-
T20832	37196-37197	-RRB-	denotes	)
T20833	37206-37210	VBD	denotes	were
T20834	37216-37217	.	denotes	.
T20835	37217-37375	sentence	denotes	Specifically, the fasting-mediated down-regulation of SREBP-1c and its target gene stearoyl-CoA desaturase (SCD1), was abolished in PGC-1α−/− mice (Table 2).
T20836	37218-37230	RB	denotes	Specifically
T20837	37337-37346	VBN	denotes	abolished
T20838	37230-37232	,	denotes	,
T20839	37232-37235	DT	denotes	the
T20840	37258-37268	NN	denotes	regulation
T20841	37236-37243	NN	denotes	fasting
T20842	37244-37252	VBN	denotes	mediated
T20843	37243-37244	HYPH	denotes	-
T20844	37253-37257	NN	denotes	down
T20845	37257-37258	HYPH	denotes	-
T20846	37269-37271	IN	denotes	of
T20847	37272-37277	NN	denotes	SREBP
T20848	37278-37280	NN	denotes	1c
T20849	37277-37278	HYPH	denotes	-
T20850	37281-37284	CC	denotes	and
T20851	37285-37288	PRP$	denotes	its
T20852	37296-37300	NN	denotes	gene
T20853	37289-37295	NN	denotes	target
T20854	37301-37309	NN	denotes	stearoyl
T20855	37314-37324	NN	denotes	desaturase
T20856	37309-37310	HYPH	denotes	-
T20857	37310-37313	NN	denotes	CoA
T20858	37325-37326	-LRB-	denotes	(
T20859	37326-37330	NN	denotes	SCD1
T20860	37330-37331	-RRB-	denotes	)
T20861	37331-37333	,	denotes	,
T20862	37333-37336	VBD	denotes	was
T20863	37347-37349	IN	denotes	in
T20864	37350-37353	NN	denotes	PGC
T20865	37354-37356	NN	denotes	1α
T20866	37353-37354	HYPH	denotes	-
T20867	37360-37364	NNS	denotes	mice
T20868	37356-37357	SYM	denotes	−
T20869	37357-37358	HYPH	denotes	/
T20870	37358-37359	SYM	denotes	−
T20871	37365-37366	-LRB-	denotes	(
T20872	37366-37371	NN	denotes	Table
T20873	37372-37373	CD	denotes	2
T20874	37373-37374	-RRB-	denotes	)
T20875	37374-37375	.	denotes	.
T20876	37375-37601	sentence	denotes	Furthermore, expression of the gene encoding diglyceride acyltransferase (DGAT), which catalyzes the last step in TAG synthesis, was activated at baseline and induced by fasting to a greater level in PGC-1α−/− mice (Table 2).
T20877	37376-37387	RB	denotes	Furthermore
T20878	37509-37518	VBN	denotes	activated
T20879	37387-37389	,	denotes	,
T20880	37389-37399	NN	denotes	expression
T20881	37400-37402	IN	denotes	of
T20882	37403-37406	DT	denotes	the
T20883	37407-37411	NN	denotes	gene
T20884	37412-37420	VBG	denotes	encoding
T20885	37421-37432	NN	denotes	diglyceride
T20886	37433-37448	NN	denotes	acyltransferase
T20887	37449-37450	-LRB-	denotes	(
T20888	37450-37454	NN	denotes	DGAT
T20889	37454-37455	-RRB-	denotes	)
T20890	37455-37457	,	denotes	,
T20891	37457-37462	WDT	denotes	which
T20892	37463-37472	VBZ	denotes	catalyzes
T20893	37473-37476	DT	denotes	the
T20894	37482-37486	NN	denotes	step
T20895	37477-37481	JJ	denotes	last
T20896	37487-37489	IN	denotes	in
T20897	37490-37493	NN	denotes	TAG
T20898	37494-37503	NN	denotes	synthesis
T20899	37503-37505	,	denotes	,
T20900	37505-37508	VBD	denotes	was
T20901	37519-37521	IN	denotes	at
T20902	37522-37530	NN	denotes	baseline
T20903	37531-37534	CC	denotes	and
T20904	37535-37542	VBN	denotes	induced
T20905	37543-37545	IN	denotes	by
T20906	37546-37553	VBG	denotes	fasting
T20907	37554-37556	IN	denotes	to
T20908	37557-37558	DT	denotes	a
T20909	37567-37572	NN	denotes	level
T20910	37559-37566	JJR	denotes	greater
T20911	37573-37575	IN	denotes	in
T20912	37576-37579	NN	denotes	PGC
T20913	37580-37582	NN	denotes	1α
T20914	37579-37580	HYPH	denotes	-
T20915	37586-37590	NNS	denotes	mice
T20916	37582-37583	SYM	denotes	−
T20917	37583-37584	HYPH	denotes	/
T20918	37584-37585	SYM	denotes	−
T20919	37591-37592	-LRB-	denotes	(
T20920	37592-37597	NN	denotes	Table
T20921	37598-37599	CD	denotes	2
T20922	37599-37600	-RRB-	denotes	)
T20923	37600-37601	.	denotes	.
T20924	37601-37744	sentence	denotes	These results suggest that, in addition to a defect in oxidation, components of the TAG synthesis pathway are activated in the PGC-1α−/− mice.
T20925	37602-37607	DT	denotes	These
T20926	37608-37615	NNS	denotes	results
T20927	37616-37623	VBP	denotes	suggest
T20928	37624-37628	IN	denotes	that
T20929	37712-37721	VBN	denotes	activated
T20930	37628-37630	,	denotes	,
T20931	37630-37632	IN	denotes	in
T20932	37633-37641	NN	denotes	addition
T20933	37642-37644	IN	denotes	to
T20934	37645-37646	DT	denotes	a
T20935	37647-37653	NN	denotes	defect
T20936	37654-37656	IN	denotes	in
T20937	37657-37666	NN	denotes	oxidation
T20938	37666-37668	,	denotes	,
T20939	37668-37678	NNS	denotes	components
T20940	37679-37681	IN	denotes	of
T20941	37682-37685	DT	denotes	the
T20942	37700-37707	NN	denotes	pathway
T20943	37686-37689	NN	denotes	TAG
T20944	37690-37699	NN	denotes	synthesis
T20945	37708-37711	VBP	denotes	are
T20946	37722-37724	IN	denotes	in
T20947	37725-37728	DT	denotes	the
T20948	37739-37743	NNS	denotes	mice
T20949	37729-37732	NN	denotes	PGC
T20950	37733-37735	NN	denotes	1α
T20951	37732-37733	HYPH	denotes	-
T20952	37735-37736	SYM	denotes	−
T20953	37736-37737	HYPH	denotes	/
T20954	37737-37738	SYM	denotes	−
T20955	37743-37744	.	denotes	.
T20956	37744-37868	sentence	denotes	To evaluate this possibility directly, rates of 3H-glycerol incorporation into TAG were determined in isolated hepatocytes.
T20957	37745-37747	TO	denotes	To
T20958	37748-37756	VB	denotes	evaluate
T20959	37833-37843	VBN	denotes	determined
T20960	37757-37761	DT	denotes	this
T20961	37762-37773	NN	denotes	possibility
T20962	37774-37782	RB	denotes	directly
T20963	37782-37784	,	denotes	,
T20964	37784-37789	NNS	denotes	rates
T20965	37790-37792	IN	denotes	of
T20966	37793-37795	NN	denotes	3H
T20967	37796-37804	NN	denotes	glycerol
T20968	37795-37796	HYPH	denotes	-
T20969	37805-37818	NN	denotes	incorporation
T20970	37819-37823	IN	denotes	into
T20971	37824-37827	NN	denotes	TAG
T20972	37828-37832	VBD	denotes	were
T20973	37844-37846	IN	denotes	in
T20974	37847-37855	VBN	denotes	isolated
T20975	37856-37867	NNS	denotes	hepatocytes
T20976	37867-37868	.	denotes	.
T20977	37868-38176	sentence	denotes	3H-TAG incorporation was increased nearly 50% in hepatocytes isolated from PGC-1α−/− mice compared to PGC-1α+/+ controls (Figure 8D), confirming that TAG synthesis rates are increased in PGC-1α null hepatocytes, identifying a second potential mechanism contributing to the fasting-induced hepatic steatosis.
T20978	37869-37871	NN	denotes	3H
T20979	37872-37875	NN	denotes	TAG
T20980	37871-37872	HYPH	denotes	-
T20981	37876-37889	NN	denotes	incorporation
T20982	37894-37903	VBN	denotes	increased
T20983	37890-37893	VBD	denotes	was
T20984	37904-37910	RB	denotes	nearly
T20985	37911-37913	CD	denotes	50
T20986	37913-37914	NN	denotes	%
T20987	37915-37917	IN	denotes	in
T20988	37918-37929	NNS	denotes	hepatocytes
T20989	37930-37938	VBN	denotes	isolated
T20990	37939-37943	IN	denotes	from
T20991	37944-37947	NN	denotes	PGC
T20992	37948-37950	NN	denotes	1α
T20993	37947-37948	HYPH	denotes	-
T20994	37954-37958	NNS	denotes	mice
T20995	37950-37951	SYM	denotes	−
T20996	37951-37952	HYPH	denotes	/
T20997	37952-37953	SYM	denotes	−
T20998	37959-37967	VBN	denotes	compared
T20999	37968-37970	IN	denotes	to
T21000	37971-37974	NN	denotes	PGC
T21001	37975-37977	NN	denotes	1α
T21002	37974-37975	HYPH	denotes	-
T21003	37981-37989	NNS	denotes	controls
T21004	37977-37978	SYM	denotes	+
T21005	37978-37979	HYPH	denotes	/
T21006	37979-37980	SYM	denotes	+
T21007	37990-37991	-LRB-	denotes	(
T21008	37998-38000	NN	denotes	8D
T21009	37991-37997	NN	denotes	Figure
T21010	38000-38001	-RRB-	denotes	)
T21011	38001-38003	,	denotes	,
T21012	38003-38013	VBG	denotes	confirming
T21013	38014-38018	IN	denotes	that
T21014	38043-38052	VBN	denotes	increased
T21015	38019-38022	NN	denotes	TAG
T21016	38023-38032	NN	denotes	synthesis
T21017	38033-38038	NNS	denotes	rates
T21018	38039-38042	VBP	denotes	are
T21019	38053-38055	IN	denotes	in
T21020	38056-38059	NN	denotes	PGC
T21021	38060-38062	NN	denotes	1α
T21022	38059-38060	HYPH	denotes	-
T21023	38063-38067	JJ	denotes	null
T21024	38068-38079	NNS	denotes	hepatocytes
T21025	38079-38081	,	denotes	,
T21026	38081-38092	VBG	denotes	identifying
T21027	38093-38094	DT	denotes	a
T21028	38112-38121	NN	denotes	mechanism
T21029	38095-38101	JJ	denotes	second
T21030	38102-38111	JJ	denotes	potential
T21031	38122-38134	VBG	denotes	contributing
T21032	38135-38137	IN	denotes	to
T21033	38138-38141	DT	denotes	the
T21034	38166-38175	NN	denotes	steatosis
T21035	38142-38149	NN	denotes	fasting
T21036	38150-38157	VBN	denotes	induced
T21037	38149-38150	HYPH	denotes	-
T21038	38158-38165	JJ	denotes	hepatic
T21039	38175-38176	.	denotes	.
T22539	38178-38185	IN	denotes	Despite
T22540	38239-38246	VB	denotes	Exhibit
T22541	38186-38187	DT	denotes	a
T22542	38199-38208	NN	denotes	Phenotype
T22543	38188-38192	JJ	denotes	Mild
T22544	38193-38198	JJ	denotes	Obese
T22545	38208-38210	,	denotes	,
T22546	38210-38216	JJ	denotes	Female
T22547	38227-38231	NNS	denotes	Mice
T22548	38217-38220	NN	denotes	PGC
T22549	38221-38223	NN	denotes	1α
T22550	38220-38221	HYPH	denotes	-
T22551	38223-38224	SYM	denotes	−
T22552	38224-38225	HYPH	denotes	/
T22553	38225-38226	SYM	denotes	−
T22554	38232-38234	VBP	denotes	Do
T22555	38235-38238	RB	denotes	Not
T22556	38247-38254	NN	denotes	Insulin
T22557	38255-38265	NN	denotes	Resistance
T22558	38265-38524	sentence	denotes	Recent studies have suggested that specific PGC-1α single nucleotide polymorphisms and haplotypes may influence the development of insulin resistance and diabetes [27,30] and that PGC-1 activity is diminished in insulin-resistant and diabetic muscle [22,23].
T22559	38266-38272	JJ	denotes	Recent
T22560	38273-38280	NNS	denotes	studies
T22561	38286-38295	VBN	denotes	suggested
T22562	38281-38285	VBP	denotes	have
T22563	38296-38300	IN	denotes	that
T22564	38368-38377	VB	denotes	influence
T22565	38301-38309	JJ	denotes	specific
T22566	38314-38316	NN	denotes	1α
T22567	38310-38313	NN	denotes	PGC
T22568	38313-38314	HYPH	denotes	-
T22569	38317-38323	JJ	denotes	single
T22570	38324-38334	NN	denotes	nucleotide
T22571	38335-38348	NNS	denotes	polymorphisms
T22572	38349-38352	CC	denotes	and
T22573	38353-38363	NNS	denotes	haplotypes
T22574	38364-38367	MD	denotes	may
T22575	38378-38381	DT	denotes	the
T22576	38382-38393	NN	denotes	development
T22577	38394-38396	IN	denotes	of
T22578	38397-38404	NN	denotes	insulin
T22579	38405-38415	NN	denotes	resistance
T22580	38416-38419	CC	denotes	and
T22581	38420-38428	NN	denotes	diabetes
T22582	38429-38430	-LRB-	denotes	[
T22583	38433-38435	CD	denotes	30
T22584	38430-38432	CD	denotes	27
T22585	38432-38433	,	denotes	,
T22586	38435-38436	-RRB-	denotes	]
T22587	38437-38440	CC	denotes	and
T22588	38441-38445	IN	denotes	that
T22589	38464-38474	VBN	denotes	diminished
T22590	38446-38449	NN	denotes	PGC
T22591	38452-38460	NN	denotes	activity
T22592	38449-38450	HYPH	denotes	-
T22593	38450-38451	CD	denotes	1
T22594	38461-38463	VBZ	denotes	is
T22595	38475-38477	IN	denotes	in
T22596	38478-38485	NN	denotes	insulin
T22597	38486-38495	JJ	denotes	resistant
T22598	38485-38486	HYPH	denotes	-
T22599	38509-38515	NN	denotes	muscle
T22600	38496-38499	CC	denotes	and
T22601	38500-38508	JJ	denotes	diabetic
T22602	38516-38517	-LRB-	denotes	[
T22603	38520-38522	CD	denotes	23
T22604	38517-38519	CD	denotes	22
T22605	38519-38520	,	denotes	,
T22606	38522-38523	-RRB-	denotes	]
T22607	38523-38524	.	denotes	.
T22608	38524-38625	sentence	denotes	Accordingly, peripheral glucose disposal and insulin responsiveness were examined in PGC-1α−/− mice.
T22609	38525-38536	RB	denotes	Accordingly
T22610	38598-38606	VBN	denotes	examined
T22611	38536-38538	,	denotes	,
T22612	38538-38548	JJ	denotes	peripheral
T22613	38557-38565	NN	denotes	disposal
T22614	38549-38556	NN	denotes	glucose
T22615	38566-38569	CC	denotes	and
T22616	38570-38577	NN	denotes	insulin
T22617	38578-38592	NN	denotes	responsiveness
T22618	38593-38597	VBD	denotes	were
T22619	38607-38609	IN	denotes	in
T22620	38610-38613	NN	denotes	PGC
T22621	38614-38616	NN	denotes	1α
T22622	38613-38614	HYPH	denotes	-
T22623	38620-38624	NNS	denotes	mice
T22624	38616-38617	SYM	denotes	−
T22625	38617-38618	HYPH	denotes	/
T22626	38618-38619	SYM	denotes	−
T22627	38624-38625	.	denotes	.
T22628	38625-38805	sentence	denotes	Glucose tolerance testing of 2-mo-old male and female mice revealed no significant difference in blood glucose excursion between PGC-1α+/+ and PGC-1α−/− groups (unpublished data).
T22629	38626-38633	NN	denotes	Glucose
T22630	38634-38643	NN	denotes	tolerance
T22631	38644-38651	NN	denotes	testing
T22632	38685-38693	VBD	denotes	revealed
T22633	38652-38654	IN	denotes	of
T22634	38655-38656	CD	denotes	2
T22635	38657-38659	NN	denotes	mo
T22636	38656-38657	HYPH	denotes	-
T22637	38660-38663	JJ	denotes	old
T22638	38659-38660	HYPH	denotes	-
T22639	38680-38684	NNS	denotes	mice
T22640	38664-38668	JJ	denotes	male
T22641	38669-38672	CC	denotes	and
T22642	38673-38679	JJ	denotes	female
T22643	38694-38696	DT	denotes	no
T22644	38709-38719	NN	denotes	difference
T22645	38697-38708	JJ	denotes	significant
T22646	38720-38722	IN	denotes	in
T22647	38723-38728	NN	denotes	blood
T22648	38729-38736	NN	denotes	glucose
T22649	38737-38746	NN	denotes	excursion
T22650	38747-38754	IN	denotes	between
T22651	38755-38758	NN	denotes	PGC
T22652	38759-38761	NN	denotes	1α
T22653	38758-38759	HYPH	denotes	-
T22654	38779-38785	NNS	denotes	groups
T22655	38761-38762	SYM	denotes	+
T22656	38762-38763	HYPH	denotes	/
T22657	38763-38764	SYM	denotes	+
T22658	38765-38768	CC	denotes	and
T22659	38769-38772	NN	denotes	PGC
T22660	38773-38775	NN	denotes	1α
T22661	38772-38773	HYPH	denotes	-
T22662	38775-38776	SYM	denotes	−
T22663	38776-38777	HYPH	denotes	/
T22664	38777-38778	SYM	denotes	−
T22665	38786-38787	-LRB-	denotes	(
T22666	38799-38803	NNS	denotes	data
T22667	38787-38798	JJ	denotes	unpublished
T22668	38803-38804	-RRB-	denotes	)
T22669	38804-38805	.	denotes	.
T22670	38805-38967	sentence	denotes	Given that older female PGC-1α−/− mice develop an increase in body fat stores, glucose tolerance and insulin responsiveness were further evaluated in this group.
T22671	38806-38811	VBN	denotes	Given
T22672	38943-38952	VBN	denotes	evaluated
T22673	38812-38816	IN	denotes	that
T22674	38845-38852	VBP	denotes	develop
T22675	38817-38822	JJR	denotes	older
T22676	38840-38844	NNS	denotes	mice
T22677	38823-38829	JJ	denotes	female
T22678	38830-38833	NN	denotes	PGC
T22679	38834-38836	NN	denotes	1α
T22680	38833-38834	HYPH	denotes	-
T22681	38836-38837	SYM	denotes	−
T22682	38837-38838	HYPH	denotes	/
T22683	38838-38839	SYM	denotes	−
T22684	38853-38855	DT	denotes	an
T22685	38856-38864	NN	denotes	increase
T22686	38865-38867	IN	denotes	in
T22687	38868-38872	NN	denotes	body
T22688	38873-38876	NN	denotes	fat
T22689	38877-38883	NNS	denotes	stores
T22690	38883-38885	,	denotes	,
T22691	38885-38892	NN	denotes	glucose
T22692	38893-38902	NN	denotes	tolerance
T22693	38903-38906	CC	denotes	and
T22694	38907-38914	NN	denotes	insulin
T22695	38915-38929	NN	denotes	responsiveness
T22696	38930-38934	VBD	denotes	were
T22697	38935-38942	RB	denotes	further
T22698	38953-38955	IN	denotes	in
T22699	38956-38960	DT	denotes	this
T22700	38961-38966	NN	denotes	group
T22701	38966-38967	.	denotes	.
T22702	38967-39307	sentence	denotes	Glucose tolerance testing in 4.5-mo-old female PGC-1α−/− mice revealed that, despite increased body weight [mean ± standard error of the mean (SEM) weight of PGC-1α+/+ mice = 22.4 ± 0.79 g; PGC-1α−/− mice = 25.2 ± 1.04 g), PGC-1α−/− mice exhibited similar levels of glucose tolerance compared to WT mice on standard rodent chow (Figure 9).
T22703	38968-38975	NN	denotes	Glucose
T22704	38976-38985	NN	denotes	tolerance
T22705	38986-38993	NN	denotes	testing
T22706	39030-39038	VBD	denotes	revealed
T22707	38994-38996	IN	denotes	in
T22708	38997-39000	CD	denotes	4.5
T22709	39001-39003	NN	denotes	mo
T22710	39000-39001	HYPH	denotes	-
T22711	39004-39007	JJ	denotes	old
T22712	39003-39004	HYPH	denotes	-
T22713	39025-39029	NNS	denotes	mice
T22714	39008-39014	JJ	denotes	female
T22715	39015-39018	NN	denotes	PGC
T22716	39019-39021	NN	denotes	1α
T22717	39018-39019	HYPH	denotes	-
T22718	39021-39022	SYM	denotes	−
T22719	39022-39023	HYPH	denotes	/
T22720	39023-39024	SYM	denotes	−
T22721	39039-39043	IN	denotes	that
T22722	39206-39215	VBD	denotes	exhibited
T22723	39043-39045	,	denotes	,
T22724	39045-39052	IN	denotes	despite
T22725	39053-39062	VBN	denotes	increased
T22726	39068-39074	NN	denotes	weight
T22727	39063-39067	NN	denotes	body
T22728	39075-39076	-LRB-	denotes	[
T22729	39187-39188	NN	denotes	g
T22730	39076-39080	NN	denotes	mean
T22731	39116-39122	NN	denotes	weight
T22732	39081-39082	SYM	denotes	±
T22733	39083-39091	JJ	denotes	standard
T22734	39092-39097	NN	denotes	error
T22735	39098-39100	IN	denotes	of
T22736	39101-39104	DT	denotes	the
T22737	39105-39109	NN	denotes	mean
T22738	39110-39111	-LRB-	denotes	(
T22739	39111-39114	NN	denotes	SEM
T22740	39114-39115	-RRB-	denotes	)
T22741	39155-39156	NN	denotes	g
T22742	39123-39125	IN	denotes	of
T22743	39126-39129	NN	denotes	PGC
T22744	39130-39132	NN	denotes	1α
T22745	39129-39130	HYPH	denotes	-
T22746	39136-39140	NNS	denotes	mice
T22747	39132-39133	SYM	denotes	+
T22748	39133-39134	HYPH	denotes	/
T22749	39134-39135	SYM	denotes	+
T22750	39141-39142	SYM	denotes	=
T22751	39143-39147	CD	denotes	22.4
T22752	39150-39154	CD	denotes	0.79
T22753	39148-39149	SYM	denotes	±
T22754	39156-39157	:	denotes	;
T22755	39158-39161	NN	denotes	PGC
T22756	39162-39164	NN	denotes	1α
T22757	39161-39162	HYPH	denotes	-
T22758	39168-39172	NNS	denotes	mice
T22759	39164-39165	SYM	denotes	−
T22760	39165-39166	HYPH	denotes	/
T22761	39166-39167	SYM	denotes	−
T22762	39173-39174	SYM	denotes	=
T22763	39175-39179	CD	denotes	25.2
T22764	39182-39186	CD	denotes	1.04
T22765	39180-39181	SYM	denotes	±
T22766	39188-39189	-RRB-	denotes	)
T22767	39189-39191	,	denotes	,
T22768	39191-39194	NN	denotes	PGC
T22769	39195-39197	NN	denotes	1α
T22770	39194-39195	HYPH	denotes	-
T22771	39201-39205	NNS	denotes	mice
T22772	39197-39198	SYM	denotes	−
T22773	39198-39199	HYPH	denotes	/
T22774	39199-39200	SYM	denotes	−
T22775	39216-39223	JJ	denotes	similar
T22776	39224-39230	NNS	denotes	levels
T22777	39231-39233	IN	denotes	of
T22778	39234-39241	NN	denotes	glucose
T22779	39242-39251	NN	denotes	tolerance
T22780	39252-39260	VBN	denotes	compared
T22781	39261-39263	IN	denotes	to
T22782	39264-39266	NN	denotes	WT
T22783	39267-39271	NNS	denotes	mice
T22784	39272-39274	IN	denotes	on
T22785	39275-39283	JJ	denotes	standard
T22786	39291-39295	NN	denotes	chow
T22787	39284-39290	NN	denotes	rodent
T22788	39296-39297	-LRB-	denotes	(
T22789	39297-39303	NN	denotes	Figure
T22790	39304-39305	CD	denotes	9
T22791	39305-39306	-RRB-	denotes	)
T22792	39306-39307	.	denotes	.
T22793	39307-39491	sentence	denotes	To examine glucose homeostasis in response to high-fat diet, female PGC-1α+/+ and PGC-1α−/− mice were placed on high-fat chow (43% calories from fat) for 6 wk starting at 8 wk of age.
T22794	39308-39310	TO	denotes	To
T22795	39311-39318	VB	denotes	examine
T22796	39410-39416	VBN	denotes	placed
T22797	39319-39326	NN	denotes	glucose
T22798	39327-39338	NN	denotes	homeostasis
T22799	39339-39341	IN	denotes	in
T22800	39342-39350	NN	denotes	response
T22801	39351-39353	IN	denotes	to
T22802	39354-39358	JJ	denotes	high
T22803	39359-39362	NN	denotes	fat
T22804	39358-39359	HYPH	denotes	-
T22805	39363-39367	NN	denotes	diet
T22806	39367-39369	,	denotes	,
T22807	39369-39375	JJ	denotes	female
T22808	39400-39404	NNS	denotes	mice
T22809	39376-39379	NN	denotes	PGC
T22810	39380-39382	NN	denotes	1α
T22811	39379-39380	HYPH	denotes	-
T22812	39382-39383	SYM	denotes	+
T22813	39383-39384	HYPH	denotes	/
T22814	39384-39385	SYM	denotes	+
T22815	39386-39389	CC	denotes	and
T22816	39390-39393	NN	denotes	PGC
T22817	39394-39396	NN	denotes	1α
T22818	39393-39394	HYPH	denotes	-
T22819	39396-39397	SYM	denotes	−
T22820	39397-39398	HYPH	denotes	/
T22821	39398-39399	SYM	denotes	−
T22822	39405-39409	VBD	denotes	were
T22823	39417-39419	IN	denotes	on
T22824	39420-39424	JJ	denotes	high
T22825	39425-39428	NN	denotes	fat
T22826	39424-39425	HYPH	denotes	-
T22827	39429-39433	NN	denotes	chow
T22828	39434-39435	-LRB-	denotes	(
T22829	39439-39447	NNS	denotes	calories
T22830	39435-39437	CD	denotes	43
T22831	39437-39438	NN	denotes	%
T22832	39448-39452	IN	denotes	from
T22833	39453-39456	NN	denotes	fat
T22834	39456-39457	-RRB-	denotes	)
T22835	39458-39461	IN	denotes	for
T22836	39462-39463	CD	denotes	6
T22837	39464-39466	NN	denotes	wk
T22838	39467-39475	VBG	denotes	starting
T22839	39476-39478	IN	denotes	at
T22840	39479-39480	CD	denotes	8
T22841	39481-39483	NN	denotes	wk
T22842	39484-39486	IN	denotes	of
T22843	39487-39490	NN	denotes	age
T22844	39490-39491	.	denotes	.
T22845	39491-39594	sentence	denotes	The weight gained on the high-fat diet was similar for the PGC-1α+/+ and PGC-1α−/− groups (Figure S3).
T22846	39492-39495	DT	denotes	The
T22847	39496-39502	NN	denotes	weight
T22848	39531-39534	VBD	denotes	was
T22849	39503-39509	VBN	denotes	gained
T22850	39510-39512	IN	denotes	on
T22851	39513-39516	DT	denotes	the
T22852	39526-39530	NN	denotes	diet
T22853	39517-39521	JJ	denotes	high
T22854	39522-39525	NN	denotes	fat
T22855	39521-39522	HYPH	denotes	-
T22856	39535-39542	JJ	denotes	similar
T22857	39543-39546	IN	denotes	for
T22858	39547-39550	DT	denotes	the
T22859	39575-39581	NNS	denotes	groups
T22860	39551-39554	NN	denotes	PGC
T22861	39555-39557	NN	denotes	1α
T22862	39554-39555	HYPH	denotes	-
T22863	39557-39558	SYM	denotes	+
T22864	39558-39559	HYPH	denotes	/
T22865	39559-39560	SYM	denotes	+
T22866	39561-39564	CC	denotes	and
T22867	39565-39568	NN	denotes	PGC
T22868	39569-39571	NN	denotes	1α
T22869	39568-39569	HYPH	denotes	-
T22870	39571-39572	SYM	denotes	−
T22871	39572-39573	HYPH	denotes	/
T22872	39573-39574	SYM	denotes	−
T22873	39582-39583	-LRB-	denotes	(
T22874	39590-39592	NN	denotes	S3
T22875	39583-39589	NN	denotes	Figure
T22876	39592-39593	-RRB-	denotes	)
T22877	39593-39594	.	denotes	.
T22878	39594-39753	sentence	denotes	Surprisingly, the PGC-1α−/− mice on a high-fat diet were significantly more glucose-tolerant and insulin-sensitive compared to the PGC-1α+/+ mice (Figure 9B).
T22879	39595-39607	RB	denotes	Surprisingly
T22880	39647-39651	VBD	denotes	were
T22881	39607-39609	,	denotes	,
T22882	39609-39612	DT	denotes	the
T22883	39623-39627	NNS	denotes	mice
T22884	39613-39616	NN	denotes	PGC
T22885	39617-39619	NN	denotes	1α
T22886	39616-39617	HYPH	denotes	-
T22887	39619-39620	SYM	denotes	−
T22888	39620-39621	HYPH	denotes	/
T22889	39621-39622	SYM	denotes	−
T22890	39628-39630	IN	denotes	on
T22891	39631-39632	DT	denotes	a
T22892	39642-39646	NN	denotes	diet
T22893	39633-39637	JJ	denotes	high
T22894	39638-39641	NN	denotes	fat
T22895	39637-39638	HYPH	denotes	-
T22896	39652-39665	RB	denotes	significantly
T22897	39666-39670	RBR	denotes	more
T22898	39679-39687	JJ	denotes	tolerant
T22899	39671-39678	NN	denotes	glucose
T22900	39678-39679	HYPH	denotes	-
T22901	39688-39691	CC	denotes	and
T22902	39692-39699	NN	denotes	insulin
T22903	39700-39709	JJ	denotes	sensitive
T22904	39699-39700	HYPH	denotes	-
T22905	39710-39718	VBN	denotes	compared
T22906	39719-39721	IN	denotes	to
T22907	39722-39725	DT	denotes	the
T22908	39736-39740	NNS	denotes	mice
T22909	39726-39729	NN	denotes	PGC
T22910	39730-39732	NN	denotes	1α
T22911	39729-39730	HYPH	denotes	-
T22912	39732-39733	SYM	denotes	+
T22913	39733-39734	HYPH	denotes	/
T22914	39734-39735	SYM	denotes	+
T22915	39741-39742	-LRB-	denotes	(
T22916	39749-39751	NN	denotes	9B
T22917	39742-39748	NN	denotes	Figure
T22918	39751-39752	-RRB-	denotes	)
T22919	39752-39753	.	denotes	.
T22920	39753-39910	sentence	denotes	Taken together, these results indicate that, despite excess body fat under standard conditions, the female PGC-1α−/− mice do not exhibit insulin resistance.
T22921	39754-39759	VBN	denotes	Taken
T22922	39784-39792	VBP	denotes	indicate
T22923	39760-39768	RB	denotes	together
T22924	39768-39770	,	denotes	,
T22925	39770-39775	DT	denotes	these
T22926	39776-39783	NNS	denotes	results
T22927	39793-39797	IN	denotes	that
T22928	39883-39890	VB	denotes	exhibit
T22929	39797-39799	,	denotes	,
T22930	39799-39806	IN	denotes	despite
T22931	39807-39813	JJ	denotes	excess
T22932	39819-39822	NN	denotes	fat
T22933	39814-39818	NN	denotes	body
T22934	39823-39828	IN	denotes	under
T22935	39829-39837	JJ	denotes	standard
T22936	39838-39848	NNS	denotes	conditions
T22937	39848-39850	,	denotes	,
T22938	39850-39853	DT	denotes	the
T22939	39871-39875	NNS	denotes	mice
T22940	39854-39860	JJ	denotes	female
T22941	39861-39864	NN	denotes	PGC
T22942	39865-39867	NN	denotes	1α
T22943	39864-39865	HYPH	denotes	-
T22944	39867-39868	SYM	denotes	−
T22945	39868-39869	HYPH	denotes	/
T22946	39869-39870	SYM	denotes	−
T22947	39876-39878	VBP	denotes	do
T22948	39879-39882	RB	denotes	not
T22949	39891-39898	NN	denotes	insulin
T22950	39899-39909	NN	denotes	resistance
T22951	39909-39910	.	denotes	.
T22952	39910-40020	sentence	denotes	Moreover, the PGC-1α−/− mice are more glucose-tolerant and insulin-sensitive than WT mice on a high-fat diet.
T22953	39911-39919	RB	denotes	Moreover
T22954	39940-39943	VBP	denotes	are
T22955	39919-39921	,	denotes	,
T22956	39921-39924	DT	denotes	the
T22957	39935-39939	NNS	denotes	mice
T22958	39925-39928	NN	denotes	PGC
T22959	39929-39931	NN	denotes	1α
T22960	39928-39929	HYPH	denotes	-
T22961	39931-39932	SYM	denotes	−
T22962	39932-39933	HYPH	denotes	/
T22963	39933-39934	SYM	denotes	−
T22964	39944-39948	RBR	denotes	more
T22965	39957-39965	JJ	denotes	tolerant
T22966	39949-39956	NN	denotes	glucose
T22967	39956-39957	HYPH	denotes	-
T22968	39966-39969	CC	denotes	and
T22969	39970-39977	NN	denotes	insulin
T22970	39978-39987	JJ	denotes	sensitive
T22971	39977-39978	HYPH	denotes	-
T22972	39988-39992	IN	denotes	than
T22973	39993-39995	NN	denotes	WT
T22974	39996-40000	NNS	denotes	mice
T22975	40001-40003	IN	denotes	on
T22976	40004-40005	DT	denotes	a
T22977	40015-40019	NN	denotes	diet
T22978	40006-40010	JJ	denotes	high
T22979	40011-40014	NN	denotes	fat
T22980	40010-40011	HYPH	denotes	-
T22981	40019-40020	.	denotes	.
T24084	40703-40713	JJ	denotes	Structural
T24085	40714-40727	NNS	denotes	Abnormalities
T24086	40728-40730	IN	denotes	of
T24087	40731-40734	DT	denotes	the
T24088	40751-40757	NN	denotes	System
T24089	40735-40742	JJ	denotes	Central
T24090	40743-40750	JJ	denotes	Nervous
T24091	40758-40760	IN	denotes	in
T24092	40761-40764	NN	denotes	PGC
T24093	40765-40767	NN	denotes	1α
T24094	40764-40765	HYPH	denotes	-
T24095	40771-40775	NNS	denotes	Mice
T24096	40767-40768	SYM	denotes	−
T24097	40768-40769	HYPH	denotes	/
T24098	40769-40770	SYM	denotes	−
T24099	40775-40876	sentence	denotes	In surveying the tissues of the PGC-1α−/− mice, structural abnormalities of the brain were observed.
T24100	40776-40778	IN	denotes	In
T24101	40867-40875	VBN	denotes	observed
T24102	40779-40788	VBG	denotes	surveying
T24103	40789-40792	DT	denotes	the
T24104	40793-40800	NNS	denotes	tissues
T24105	40801-40803	IN	denotes	of
T24106	40804-40807	DT	denotes	the
T24107	40818-40822	NNS	denotes	mice
T24108	40808-40811	NN	denotes	PGC
T24109	40812-40814	NN	denotes	1α
T24110	40811-40812	HYPH	denotes	-
T24111	40814-40815	SYM	denotes	−
T24112	40815-40816	HYPH	denotes	/
T24113	40816-40817	SYM	denotes	−
T24114	40822-40824	,	denotes	,
T24115	40824-40834	JJ	denotes	structural
T24116	40835-40848	NNS	denotes	abnormalities
T24117	40849-40851	IN	denotes	of
T24118	40852-40855	DT	denotes	the
T24119	40856-40861	NN	denotes	brain
T24120	40862-40866	VBD	denotes	were
T24121	40875-40876	.	denotes	.
T24122	40876-41189	sentence	denotes	Light microscopic examination of PGC-1α−/− brain tissue samples demonstrated a well-preserved cerebral cortical neuronal complement, a result confirmed by measurement of neuron density in sections of the parietal lobe (PGC-1α+/+, 1,261 ± 91 neurons/mm2 versus PGC-1α−/−, 1,299 ± 82 neurons/mm2; not significant).
T24123	40877-40882	NN	denotes	Light
T24124	40883-40894	JJ	denotes	microscopic
T24125	40895-40906	NN	denotes	examination
T24126	40941-40953	VBD	denotes	demonstrated
T24127	40907-40909	IN	denotes	of
T24128	40910-40913	NN	denotes	PGC
T24129	40914-40916	NN	denotes	1α
T24130	40913-40914	HYPH	denotes	-
T24131	40933-40940	NNS	denotes	samples
T24132	40916-40917	SYM	denotes	−
T24133	40917-40918	HYPH	denotes	/
T24134	40918-40919	SYM	denotes	−
T24135	40920-40925	NN	denotes	brain
T24136	40926-40932	NN	denotes	tissue
T24137	40954-40955	DT	denotes	a
T24138	40998-41008	NN	denotes	complement
T24139	40956-40960	RB	denotes	well
T24140	40961-40970	VBN	denotes	preserved
T24141	40960-40961	HYPH	denotes	-
T24142	40971-40979	JJ	denotes	cerebral
T24143	40980-40988	JJ	denotes	cortical
T24144	40989-40997	JJ	denotes	neuronal
T24145	41008-41010	,	denotes	,
T24146	41010-41011	DT	denotes	a
T24147	41012-41018	NN	denotes	result
T24148	41019-41028	VBN	denotes	confirmed
T24149	41029-41031	IN	denotes	by
T24150	41032-41043	NN	denotes	measurement
T24151	41044-41046	IN	denotes	of
T24152	41047-41053	NN	denotes	neuron
T24153	41054-41061	NN	denotes	density
T24154	41062-41064	IN	denotes	in
T24155	41065-41073	NNS	denotes	sections
T24156	41074-41076	IN	denotes	of
T24157	41077-41080	DT	denotes	the
T24158	41090-41094	NN	denotes	lobe
T24159	41081-41089	JJ	denotes	parietal
T24160	41095-41096	-LRB-	denotes	(
T24161	41176-41187	JJ	denotes	significant
T24162	41096-41099	NN	denotes	PGC
T24163	41100-41102	NN	denotes	1α
T24164	41099-41100	HYPH	denotes	-
T24165	41118-41125	NNS	denotes	neurons
T24166	41102-41103	SYM	denotes	+
T24167	41103-41104	HYPH	denotes	/
T24168	41104-41105	SYM	denotes	+
T24169	41105-41107	,	denotes	,
T24170	41107-41112	CD	denotes	1,261
T24171	41115-41117	CD	denotes	91
T24172	41113-41114	SYM	denotes	±
T24173	41125-41126	SYM	denotes	/
T24174	41126-41129	NN	denotes	mm2
T24175	41130-41136	CC	denotes	versus
T24176	41137-41140	NN	denotes	PGC
T24177	41141-41143	NN	denotes	1α
T24178	41140-41141	HYPH	denotes	-
T24179	41159-41166	NNS	denotes	neurons
T24180	41143-41144	SYM	denotes	−
T24181	41144-41145	HYPH	denotes	/
T24182	41145-41146	SYM	denotes	−
T24183	41146-41148	,	denotes	,
T24184	41148-41153	CD	denotes	1,299
T24185	41156-41158	CD	denotes	82
T24186	41154-41155	SYM	denotes	±
T24187	41166-41167	SYM	denotes	/
T24188	41167-41170	NN	denotes	mm2
T24189	41170-41171	:	denotes	;
T24190	41172-41175	RB	denotes	not
T24191	41187-41188	-RRB-	denotes	)
T24192	41188-41189	.	denotes	.
T24193	41189-41394	sentence	denotes	Patchy areas of microvacuolation involving the neuropil and individual pyramidal neurons of the deep layers of the cerebral cortex were noted in the PGC-1α−/− mice but not the PGC-1α+/+ mice (Figure 10A).
T24194	41190-41196	JJ	denotes	Patchy
T24195	41197-41202	NNS	denotes	areas
T24196	41326-41331	VBN	denotes	noted
T24197	41203-41205	IN	denotes	of
T24198	41206-41222	NN	denotes	microvacuolation
T24199	41223-41232	VBG	denotes	involving
T24200	41233-41236	DT	denotes	the
T24201	41237-41245	NN	denotes	neuropil
T24202	41246-41249	CC	denotes	and
T24203	41250-41260	JJ	denotes	individual
T24204	41271-41278	NNS	denotes	neurons
T24205	41261-41270	JJ	denotes	pyramidal
T24206	41279-41281	IN	denotes	of
T24207	41282-41285	DT	denotes	the
T24208	41291-41297	NNS	denotes	layers
T24209	41286-41290	JJ	denotes	deep
T24210	41298-41300	IN	denotes	of
T24211	41301-41304	DT	denotes	the
T24212	41314-41320	NN	denotes	cortex
T24213	41305-41313	JJ	denotes	cerebral
T24214	41321-41325	VBD	denotes	were
T24215	41332-41334	IN	denotes	in
T24216	41335-41338	DT	denotes	the
T24217	41349-41353	NNS	denotes	mice
T24218	41339-41342	NN	denotes	PGC
T24219	41343-41345	NN	denotes	1α
T24220	41342-41343	HYPH	denotes	-
T24221	41345-41346	SYM	denotes	−
T24222	41346-41347	HYPH	denotes	/
T24223	41347-41348	SYM	denotes	−
T24224	41354-41357	CC	denotes	but
T24225	41358-41361	RB	denotes	not
T24226	41362-41365	DT	denotes	the
T24227	41376-41380	NNS	denotes	mice
T24228	41366-41369	NN	denotes	PGC
T24229	41370-41372	NN	denotes	1α
T24230	41369-41370	HYPH	denotes	-
T24231	41372-41373	SYM	denotes	+
T24232	41373-41374	HYPH	denotes	/
T24233	41374-41375	SYM	denotes	+
T24234	41381-41382	-LRB-	denotes	(
T24235	41389-41392	NN	denotes	10A
T24236	41382-41388	NN	denotes	Figure
T24237	41392-41393	-RRB-	denotes	)
T24238	41393-41394	.	denotes	.
T24239	41394-41588	sentence	denotes	Immunolocalization of an astrocytic marker, glial fibrillary acidic protein, failed to show an increase in numbers of astrocytic processes in PGC-1α−/− mouse cerebral cortex (unpublished data).
T24240	41395-41413	NN	denotes	Immunolocalization
T24241	41472-41478	VBD	denotes	failed
T24242	41414-41416	IN	denotes	of
T24243	41417-41419	DT	denotes	an
T24244	41431-41437	NN	denotes	marker
T24245	41420-41430	JJ	denotes	astrocytic
T24246	41437-41439	,	denotes	,
T24247	41439-41444	JJ	denotes	glial
T24248	41463-41470	NN	denotes	protein
T24249	41445-41455	JJ	denotes	fibrillary
T24250	41456-41462	JJ	denotes	acidic
T24251	41470-41472	,	denotes	,
T24252	41479-41481	TO	denotes	to
T24253	41482-41486	VB	denotes	show
T24254	41487-41489	DT	denotes	an
T24255	41490-41498	NN	denotes	increase
T24256	41499-41501	IN	denotes	in
T24257	41502-41509	NNS	denotes	numbers
T24258	41510-41512	IN	denotes	of
T24259	41513-41523	JJ	denotes	astrocytic
T24260	41524-41533	NNS	denotes	processes
T24261	41534-41536	IN	denotes	in
T24262	41537-41540	NN	denotes	PGC
T24263	41541-41543	NN	denotes	1α
T24264	41540-41541	HYPH	denotes	-
T24265	41562-41568	NN	denotes	cortex
T24266	41543-41544	SYM	denotes	−
T24267	41544-41545	HYPH	denotes	/
T24268	41545-41546	SYM	denotes	−
T24269	41547-41552	NN	denotes	mouse
T24270	41553-41561	JJ	denotes	cerebral
T24271	41569-41570	-LRB-	denotes	(
T24272	41582-41586	NNS	denotes	data
T24273	41570-41581	JJ	denotes	unpublished
T24274	41586-41587	-RRB-	denotes	)
T24275	41587-41588	.	denotes	.
T24276	41588-41695	sentence	denotes	The hippocampus also showed neuronal microvacuolation, albeit to a lesser degree than the parietal cortex.
T24277	41589-41592	DT	denotes	The
T24278	41593-41604	NN	denotes	hippocampus
T24279	41610-41616	VBD	denotes	showed
T24280	41605-41609	RB	denotes	also
T24281	41617-41625	JJ	denotes	neuronal
T24282	41626-41642	NN	denotes	microvacuolation
T24283	41642-41644	,	denotes	,
T24284	41644-41650	IN	denotes	albeit
T24285	41651-41653	IN	denotes	to
T24286	41654-41655	DT	denotes	a
T24287	41663-41669	NN	denotes	degree
T24288	41656-41662	JJR	denotes	lesser
T24289	41670-41674	IN	denotes	than
T24290	41675-41678	DT	denotes	the
T24291	41688-41694	NN	denotes	cortex
T24292	41679-41687	JJ	denotes	parietal
T24293	41694-41695	.	denotes	.
T24294	41695-41965	sentence	denotes	Microvacuolation of the neuropil and neurons of the PGC-1α−/− basal ganglia (caudate and putamen) was also noted in association with a patchy increase in the number and intensity of glial fibrillary acidic protein-immunoreactive astrocytic processes (unpublished data).
T24295	41696-41712	NN	denotes	Microvacuolation
T24296	41803-41808	VBN	denotes	noted
T24297	41713-41715	IN	denotes	of
T24298	41716-41719	DT	denotes	the
T24299	41720-41728	NN	denotes	neuropil
T24300	41729-41732	CC	denotes	and
T24301	41733-41740	NNS	denotes	neurons
T24302	41741-41743	IN	denotes	of
T24303	41744-41747	DT	denotes	the
T24304	41764-41771	NNS	denotes	ganglia
T24305	41748-41751	NN	denotes	PGC
T24306	41752-41754	NN	denotes	1α
T24307	41751-41752	HYPH	denotes	-
T24308	41754-41755	SYM	denotes	−
T24309	41755-41756	HYPH	denotes	/
T24310	41756-41757	SYM	denotes	−
T24311	41758-41763	JJ	denotes	basal
T24312	41772-41773	-LRB-	denotes	(
T24313	41773-41780	NN	denotes	caudate
T24314	41781-41784	CC	denotes	and
T24315	41785-41792	NN	denotes	putamen
T24316	41792-41793	-RRB-	denotes	)
T24317	41794-41797	VBD	denotes	was
T24318	41798-41802	RB	denotes	also
T24319	41809-41811	IN	denotes	in
T24320	41812-41823	NN	denotes	association
T24321	41824-41828	IN	denotes	with
T24322	41829-41830	DT	denotes	a
T24323	41838-41846	NN	denotes	increase
T24324	41831-41837	JJ	denotes	patchy
T24325	41847-41849	IN	denotes	in
T24326	41850-41853	DT	denotes	the
T24327	41854-41860	NN	denotes	number
T24328	41861-41864	CC	denotes	and
T24329	41865-41874	NN	denotes	intensity
T24330	41875-41877	IN	denotes	of
T24331	41878-41883	JJ	denotes	glial
T24332	41902-41909	NN	denotes	protein
T24333	41884-41894	JJ	denotes	fibrillary
T24334	41895-41901	JJ	denotes	acidic
T24335	41910-41924	JJ	denotes	immunoreactive
T24336	41909-41910	HYPH	denotes	-
T24337	41936-41945	NNS	denotes	processes
T24338	41925-41935	JJ	denotes	astrocytic
T24339	41946-41947	-LRB-	denotes	(
T24340	41959-41963	NNS	denotes	data
T24341	41947-41958	JJ	denotes	unpublished
T24342	41963-41964	-RRB-	denotes	)
T24343	41964-41965	.	denotes	.
T24344	41965-42033	sentence	denotes	Areas of microvacuolation also involved multiple brainstem regions.
T24345	41966-41971	NNS	denotes	Areas
T24346	41997-42005	VBD	denotes	involved
T24347	41972-41974	IN	denotes	of
T24348	41975-41991	NN	denotes	microvacuolation
T24349	41992-41996	RB	denotes	also
T24350	42006-42014	JJ	denotes	multiple
T24351	42025-42032	NNS	denotes	regions
T24352	42015-42024	NN	denotes	brainstem
T24353	42032-42033	.	denotes	.
T24354	42033-42140	sentence	denotes	Only rare vacuolated Purkinje and granule cell neurons were identified in the PGC-1α−/− cerebellar cortex.
T24355	42034-42038	RB	denotes	Only
T24356	42081-42088	NNS	denotes	neurons
T24357	42039-42043	JJ	denotes	rare
T24358	42044-42054	VBN	denotes	vacuolated
T24359	42055-42063	NN	denotes	Purkinje
T24360	42064-42067	CC	denotes	and
T24361	42068-42075	NN	denotes	granule
T24362	42076-42080	NN	denotes	cell
T24363	42094-42104	VBN	denotes	identified
T24364	42089-42093	VBD	denotes	were
T24365	42105-42107	IN	denotes	in
T24366	42108-42111	DT	denotes	the
T24367	42133-42139	NN	denotes	cortex
T24368	42112-42115	NN	denotes	PGC
T24369	42116-42118	NN	denotes	1α
T24370	42115-42116	HYPH	denotes	-
T24371	42118-42119	SYM	denotes	−
T24372	42119-42120	HYPH	denotes	/
T24373	42120-42121	SYM	denotes	−
T24374	42122-42132	JJ	denotes	cerebellar
T24375	42139-42140	.	denotes	.
T24376	42140-42260	sentence	denotes	Neither microglial proliferation nor perivascular lymphocytic inflammatory infiltrates were noted in the PGC-1α−/− CNS.
T24377	42141-42148	CC	denotes	Neither
T24378	42160-42173	NN	denotes	proliferation
T24379	42149-42159	JJ	denotes	microglial
T24380	42233-42238	VBN	denotes	noted
T24381	42174-42177	CC	denotes	nor
T24382	42178-42190	JJ	denotes	perivascular
T24383	42216-42227	NNS	denotes	infiltrates
T24384	42191-42202	JJ	denotes	lymphocytic
T24385	42203-42215	JJ	denotes	inflammatory
T24386	42228-42232	VBD	denotes	were
T24387	42239-42241	IN	denotes	in
T24388	42242-42245	DT	denotes	the
T24389	42256-42259	NN	denotes	CNS
T24390	42246-42249	NN	denotes	PGC
T24391	42250-42252	NN	denotes	1α
T24392	42249-42250	HYPH	denotes	-
T24393	42252-42253	SYM	denotes	−
T24394	42253-42254	HYPH	denotes	/
T24395	42254-42255	SYM	denotes	−
T24396	42259-42260	.	denotes	.
T24397	42260-42989	sentence	denotes	Figure 10 Neuropathology of the Central Nervous System of PGC-1α−/− Mice (A) Light microscopic appearance of representative cerebral cortex of 2-mo-old PGC-1α−/− mice demonstrates marked vacuolation of the neuropil (arrows) and scattered neuronal perikarya, which are absent in PGC-1α+/+ mice (hematoxylin and eosin). The scale bar shown is applicable to all sections. (B) Ultrastructural appearance of typical vacuoles containing membranous debris, denoted by the arrow, in the cerebral cortex of a representative PGC-1α−/− mouse in comparison to PGC-1α+/+ (magnification 4000×). Ultrastructural examination of the PGC-1α−/− parietal cerebral cortex confirmed the presence of microvacuolated neurons and neuropil (Figure 10B).
T24398	42843-42858	JJ	denotes	Ultrastructural
T24399	42859-42870	NN	denotes	examination
T24400	42913-42922	VBD	denotes	confirmed
T24401	42871-42873	IN	denotes	of
T24402	42874-42877	DT	denotes	the
T24403	42906-42912	NN	denotes	cortex
T24404	42878-42881	NN	denotes	PGC
T24405	42882-42884	NN	denotes	1α
T24406	42881-42882	HYPH	denotes	-
T24407	42884-42885	SYM	denotes	−
T24408	42885-42886	HYPH	denotes	/
T24409	42886-42887	SYM	denotes	−
T24410	42888-42896	JJ	denotes	parietal
T24411	42897-42905	JJ	denotes	cerebral
T24412	42923-42926	DT	denotes	the
T24413	42927-42935	NN	denotes	presence
T24414	42936-42938	IN	denotes	of
T24415	42939-42954	VBN	denotes	microvacuolated
T24416	42955-42962	NNS	denotes	neurons
T24417	42963-42966	CC	denotes	and
T24418	42967-42975	NN	denotes	neuropil
T24419	42976-42977	-LRB-	denotes	(
T24420	42984-42987	NN	denotes	10B
T24421	42977-42983	NN	denotes	Figure
T24422	42987-42988	-RRB-	denotes	)
T24423	42988-42989	.	denotes	.
T24424	42989-43089	sentence	denotes	Vacuoles containing aggregates of membranous material were present in a subset of cortical neurons.
T24425	42990-42998	NNS	denotes	Vacuoles
T24426	43044-43048	VBD	denotes	were
T24427	42999-43009	VBG	denotes	containing
T24428	43010-43020	NNS	denotes	aggregates
T24429	43021-43023	IN	denotes	of
T24430	43024-43034	JJ	denotes	membranous
T24431	43035-43043	NN	denotes	material
T24432	43049-43056	JJ	denotes	present
T24433	43057-43059	IN	denotes	in
T24434	43060-43061	DT	denotes	a
T24435	43062-43068	NN	denotes	subset
T24436	43069-43071	IN	denotes	of
T24437	43072-43080	JJ	denotes	cortical
T24438	43081-43088	NNS	denotes	neurons
T24439	43088-43089	.	denotes	.
T24440	43089-43331	sentence	denotes	Subcellular localization of the vacuoles was difficult to establish; some may represent vacuolated elements of the neuropil, material in phagocytic cells, presynaptic nerve terminals compressing the soma, or genuine intraperikaryal deposits.
T24441	43090-43101	JJ	denotes	Subcellular
T24442	43102-43114	NN	denotes	localization
T24443	43131-43134	VBD	denotes	was
T24444	43115-43117	IN	denotes	of
T24445	43118-43121	DT	denotes	the
T24446	43122-43130	NNS	denotes	vacuoles
T24447	43168-43177	VB	denotes	represent
T24448	43135-43144	JJ	denotes	difficult
T24449	43145-43147	TO	denotes	to
T24450	43148-43157	VB	denotes	establish
T24451	43157-43158	:	denotes	;
T24452	43159-43163	DT	denotes	some
T24453	43164-43167	MD	denotes	may
T24454	43178-43188	VBN	denotes	vacuolated
T24455	43189-43197	NNS	denotes	elements
T24456	43198-43200	IN	denotes	of
T24457	43201-43204	DT	denotes	the
T24458	43205-43213	NN	denotes	neuropil
T24459	43213-43215	,	denotes	,
T24460	43215-43223	NN	denotes	material
T24461	43224-43226	IN	denotes	in
T24462	43227-43237	JJ	denotes	phagocytic
T24463	43238-43243	NNS	denotes	cells
T24464	43243-43245	,	denotes	,
T24465	43245-43256	JJ	denotes	presynaptic
T24466	43263-43272	NNS	denotes	terminals
T24467	43257-43262	NN	denotes	nerve
T24468	43273-43284	VBG	denotes	compressing
T24469	43285-43288	DT	denotes	the
T24470	43289-43293	NN	denotes	soma
T24471	43293-43295	,	denotes	,
T24472	43295-43297	CC	denotes	or
T24473	43298-43305	JJ	denotes	genuine
T24474	43322-43330	NNS	denotes	deposits
T24475	43306-43321	JJ	denotes	intraperikaryal
T24476	43330-43331	.	denotes	.
T30442	43344-43352	JJ	denotes	Previous
T30443	43353-43360	NNS	denotes	studies
T30444	43400-43405	VBN	denotes	shown
T30445	43361-43366	VBG	denotes	using
T30446	43367-43371	NN	denotes	gain
T30447	43384-43394	NNS	denotes	strategies
T30448	43371-43372	HYPH	denotes	-
T30449	43372-43374	IN	denotes	of
T30450	43374-43375	HYPH	denotes	-
T30451	43375-43383	NN	denotes	function
T30452	43395-43399	VBP	denotes	have
T30453	43406-43410	IN	denotes	that
T30454	43434-43436	VBZ	denotes	is
T30455	43411-43414	DT	denotes	the
T30456	43415-43426	NN	denotes	coactivator
T30457	43427-43430	NN	denotes	PGC
T30458	43431-43433	NN	denotes	1α
T30459	43430-43431	HYPH	denotes	-
T30460	43437-43444	JJ	denotes	capable
T30461	43445-43447	IN	denotes	of
T30462	43448-43460	VBG	denotes	coactivating
T30463	43461-43463	DT	denotes	an
T30464	43464-43469	NN	denotes	array
T30465	43470-43472	IN	denotes	of
T30466	43473-43486	NN	denotes	transcription
T30467	43487-43494	NNS	denotes	factors
T30468	43495-43503	VBN	denotes	involved
T30469	43504-43506	IN	denotes	in
T30470	43507-43513	NN	denotes	energy
T30471	43524-43533	NNS	denotes	processes
T30472	43514-43523	JJ	denotes	metabolic
T30473	43534-43543	VBG	denotes	including
T30474	43544-43549	JJ	denotes	fatty
T30475	43550-43554	NN	denotes	acid
T30476	43555-43564	NN	denotes	oxidation
T30477	43564-43566	,	denotes	,
T30478	43566-43574	NN	denotes	electron
T30479	43575-43584	NN	denotes	transport
T30480	43584-43586	,	denotes	,
T30481	43586-43589	CC	denotes	and
T30482	43590-43599	JJ	denotes	oxidative
T30483	43600-43615	NN	denotes	phosphorylation
T30484	43616-43617	-LRB-	denotes	[
T30485	43617-43618	CD	denotes	6
T30486	43618-43619	-RRB-	denotes	]
T30487	43619-43620	.	denotes	.
T30488	43620-43820	sentence	denotes	Forced expression of PGC-1α triggers mitochondrial biogenesis by activating a complex circuitry of factors including NRF-1, NRF-2, and the orphan nuclear receptor estrogen-related receptor α [23,32].
T30489	43621-43627	VBN	denotes	Forced
T30490	43628-43638	NN	denotes	expression
T30491	43649-43657	VBZ	denotes	triggers
T30492	43639-43641	IN	denotes	of
T30493	43642-43645	NN	denotes	PGC
T30494	43646-43648	NN	denotes	1α
T30495	43645-43646	HYPH	denotes	-
T30496	43658-43671	JJ	denotes	mitochondrial
T30497	43672-43682	NN	denotes	biogenesis
T30498	43683-43685	IN	denotes	by
T30499	43686-43696	VBG	denotes	activating
T30500	43697-43698	DT	denotes	a
T30501	43707-43716	NN	denotes	circuitry
T30502	43699-43706	JJ	denotes	complex
T30503	43717-43719	IN	denotes	of
T30504	43720-43727	NNS	denotes	factors
T30505	43728-43737	VBG	denotes	including
T30506	43738-43741	NN	denotes	NRF
T30507	43741-43742	HYPH	denotes	-
T30508	43742-43743	CD	denotes	1
T30509	43743-43745	,	denotes	,
T30510	43745-43748	NN	denotes	NRF
T30511	43748-43749	HYPH	denotes	-
T30512	43749-43750	CD	denotes	2
T30513	43750-43752	,	denotes	,
T30514	43752-43755	CC	denotes	and
T30515	43756-43759	DT	denotes	the
T30516	43775-43783	NN	denotes	receptor
T30517	43760-43766	NN	denotes	orphan
T30518	43767-43774	JJ	denotes	nuclear
T30519	43784-43792	NN	denotes	estrogen
T30520	43793-43800	VBN	denotes	related
T30521	43792-43793	HYPH	denotes	-
T30522	43810-43811	NN	denotes	α
T30523	43801-43809	NN	denotes	receptor
T30524	43812-43813	-LRB-	denotes	[
T30525	43816-43818	CD	denotes	32
T30526	43813-43815	CD	denotes	23
T30527	43815-43816	,	denotes	,
T30528	43818-43819	-RRB-	denotes	]
T30529	43819-43820	.	denotes	.
T30530	43820-43991	sentence	denotes	However, gain-of-function strategies cannot determine whether PGC-1α is essential for critical energy metabolic processes including mitochondrial biogenesis and function.
T30531	43821-43828	RB	denotes	However
T30532	43865-43874	VB	denotes	determine
T30533	43828-43830	,	denotes	,
T30534	43830-43834	NN	denotes	gain
T30535	43847-43857	NNS	denotes	strategies
T30536	43834-43835	HYPH	denotes	-
T30537	43835-43837	IN	denotes	of
T30538	43837-43838	HYPH	denotes	-
T30539	43838-43846	NN	denotes	function
T30540	43858-43861	MD	denotes	can
T30541	43861-43864	RB	denotes	not
T30542	43875-43882	IN	denotes	whether
T30543	43890-43892	VBZ	denotes	is
T30544	43883-43886	NN	denotes	PGC
T30545	43887-43889	NN	denotes	1α
T30546	43886-43887	HYPH	denotes	-
T30547	43893-43902	JJ	denotes	essential
T30548	43903-43906	IN	denotes	for
T30549	43907-43915	JJ	denotes	critical
T30550	43933-43942	NNS	denotes	processes
T30551	43916-43922	NN	denotes	energy
T30552	43923-43932	JJ	denotes	metabolic
T30553	43943-43952	VBG	denotes	including
T30554	43953-43966	JJ	denotes	mitochondrial
T30555	43967-43977	NN	denotes	biogenesis
T30556	43978-43981	CC	denotes	and
T30557	43982-43990	NN	denotes	function
T30558	43990-43991	.	denotes	.
T30559	43991-44161	sentence	denotes	Using targeted gene deletion in mice, we show here that PGC-1α is not essential for normal embryologic development or the fundamental events of mitochondrial biogenesis.
T30560	43992-43997	VBG	denotes	Using
T30561	44033-44037	VBP	denotes	show
T30562	43998-44006	VBN	denotes	targeted
T30563	44012-44020	NN	denotes	deletion
T30564	44007-44011	NN	denotes	gene
T30565	44021-44023	IN	denotes	in
T30566	44024-44028	NNS	denotes	mice
T30567	44028-44030	,	denotes	,
T30568	44030-44032	PRP	denotes	we
T30569	44038-44042	RB	denotes	here
T30570	44043-44047	IN	denotes	that
T30571	44055-44057	VBZ	denotes	is
T30572	44048-44051	NN	denotes	PGC
T30573	44052-44054	NN	denotes	1α
T30574	44051-44052	HYPH	denotes	-
T30575	44058-44061	RB	denotes	not
T30576	44062-44071	JJ	denotes	essential
T30577	44072-44075	IN	denotes	for
T30578	44076-44082	JJ	denotes	normal
T30579	44095-44106	NN	denotes	development
T30580	44083-44094	JJ	denotes	embryologic
T30581	44107-44109	CC	denotes	or
T30582	44110-44113	DT	denotes	the
T30583	44126-44132	NNS	denotes	events
T30584	44114-44125	JJ	denotes	fundamental
T30585	44133-44135	IN	denotes	of
T30586	44136-44149	JJ	denotes	mitochondrial
T30587	44150-44160	NN	denotes	biogenesis
T30588	44160-44161	.	denotes	.
T30589	44161-44436	sentence	denotes	However, several lines of evidence support the conclusion that PGC-1α is necessary for the programs that regulate postnatal mitochondrial function and cellular energy metabolism, processes that equip the organism for the energy metabolic rigors of the postnatal environment.
T30590	44162-44169	RB	denotes	However
T30591	44197-44204	VBP	denotes	support
T30592	44169-44171	,	denotes	,
T30593	44171-44178	JJ	denotes	several
T30594	44179-44184	NNS	denotes	lines
T30595	44185-44187	IN	denotes	of
T30596	44188-44196	NN	denotes	evidence
T30597	44205-44208	DT	denotes	the
T30598	44209-44219	NN	denotes	conclusion
T30599	44220-44224	IN	denotes	that
T30600	44232-44234	VBZ	denotes	is
T30601	44225-44228	NN	denotes	PGC
T30602	44229-44231	NN	denotes	1α
T30603	44228-44229	HYPH	denotes	-
T30604	44235-44244	JJ	denotes	necessary
T30605	44245-44248	IN	denotes	for
T30606	44249-44252	DT	denotes	the
T30607	44253-44261	NNS	denotes	programs
T30608	44262-44266	WDT	denotes	that
T30609	44267-44275	VBP	denotes	regulate
T30610	44276-44285	JJ	denotes	postnatal
T30611	44300-44308	NN	denotes	function
T30612	44286-44299	JJ	denotes	mitochondrial
T30613	44309-44312	CC	denotes	and
T30614	44313-44321	JJ	denotes	cellular
T30615	44329-44339	NN	denotes	metabolism
T30616	44322-44328	NN	denotes	energy
T30617	44339-44341	,	denotes	,
T30618	44341-44350	NNS	denotes	processes
T30619	44351-44355	WDT	denotes	that
T30620	44356-44361	VBP	denotes	equip
T30621	44362-44365	DT	denotes	the
T30622	44366-44374	NN	denotes	organism
T30623	44375-44378	IN	denotes	for
T30624	44379-44382	DT	denotes	the
T30625	44400-44406	NNS	denotes	rigors
T30626	44383-44389	NN	denotes	energy
T30627	44390-44399	JJ	denotes	metabolic
T30628	44407-44409	IN	denotes	of
T30629	44410-44413	DT	denotes	the
T30630	44424-44435	NN	denotes	environment
T30631	44414-44423	JJ	denotes	postnatal
T30632	44435-44436	.	denotes	.
T30633	44436-44536	sentence	denotes	First, mitochondrial volume density is diminished in slow-twitch skeletal muscle of PGC-1α−/− mice.
T30634	44437-44442	RB	denotes	First
T30635	44476-44486	VBN	denotes	diminished
T30636	44442-44444	,	denotes	,
T30637	44444-44457	JJ	denotes	mitochondrial
T30638	44465-44472	NN	denotes	density
T30639	44458-44464	NN	denotes	volume
T30640	44473-44475	VBZ	denotes	is
T30641	44487-44489	IN	denotes	in
T30642	44490-44494	JJ	denotes	slow
T30643	44495-44501	NN	denotes	twitch
T30644	44494-44495	HYPH	denotes	-
T30645	44511-44517	NN	denotes	muscle
T30646	44502-44510	JJ	denotes	skeletal
T30647	44518-44520	IN	denotes	of
T30648	44521-44524	NN	denotes	PGC
T30649	44525-44527	NN	denotes	1α
T30650	44524-44525	HYPH	denotes	-
T30651	44531-44535	NNS	denotes	mice
T30652	44527-44528	SYM	denotes	−
T30653	44528-44529	HYPH	denotes	/
T30654	44529-44530	SYM	denotes	−
T30655	44535-44536	.	denotes	.
T30656	44536-44665	sentence	denotes	Second, mitochondrial respiratory capacity is modestly but significantly altered in skeletal muscle and liver of PGC-1α−/− mice.
T30657	44537-44543	RB	denotes	Second
T30658	44610-44617	VBN	denotes	altered
T30659	44543-44545	,	denotes	,
T30660	44545-44558	JJ	denotes	mitochondrial
T30661	44571-44579	NN	denotes	capacity
T30662	44559-44570	JJ	denotes	respiratory
T30663	44580-44582	VBZ	denotes	is
T30664	44583-44591	RB	denotes	modestly
T30665	44592-44595	CC	denotes	but
T30666	44596-44609	RB	denotes	significantly
T30667	44618-44620	IN	denotes	in
T30668	44621-44629	JJ	denotes	skeletal
T30669	44630-44636	NN	denotes	muscle
T30670	44637-44640	CC	denotes	and
T30671	44641-44646	NN	denotes	liver
T30672	44647-44649	IN	denotes	of
T30673	44650-44653	NN	denotes	PGC
T30674	44654-44656	NN	denotes	1α
T30675	44653-44654	HYPH	denotes	-
T30676	44660-44664	NNS	denotes	mice
T30677	44656-44657	SYM	denotes	−
T30678	44657-44658	HYPH	denotes	/
T30679	44658-44659	SYM	denotes	−
T30680	44664-44665	.	denotes	.
T30681	44665-44786	sentence	denotes	Third, the growth of heart and soleus muscle, tissues with high reliance on mitochondrial energy production, is blunted.
T30682	44666-44671	RB	denotes	Third
T30683	44778-44785	VBN	denotes	blunted
T30684	44671-44673	,	denotes	,
T30685	44673-44676	DT	denotes	the
T30686	44677-44683	NN	denotes	growth
T30687	44684-44686	IN	denotes	of
T30688	44687-44692	NN	denotes	heart
T30689	44693-44696	CC	denotes	and
T30690	44697-44703	NN	denotes	soleus
T30691	44704-44710	NN	denotes	muscle
T30692	44710-44712	,	denotes	,
T30693	44712-44719	NNS	denotes	tissues
T30694	44720-44724	IN	denotes	with
T30695	44725-44729	JJ	denotes	high
T30696	44730-44738	NN	denotes	reliance
T30697	44739-44741	IN	denotes	on
T30698	44742-44755	JJ	denotes	mitochondrial
T30699	44763-44773	NN	denotes	production
T30700	44756-44762	NN	denotes	energy
T30701	44773-44775	,	denotes	,
T30702	44775-44777	VBZ	denotes	is
T30703	44785-44786	.	denotes	.
T30704	44786-44854	sentence	denotes	Fourth, control of body fat mass is abnormal in the PGC-1α−/− mice.
T30705	44787-44793	RB	denotes	Fourth
T30706	44820-44822	VBZ	denotes	is
T30707	44793-44795	,	denotes	,
T30708	44795-44802	NN	denotes	control
T30709	44803-44805	IN	denotes	of
T30710	44806-44810	NN	denotes	body
T30711	44811-44814	NN	denotes	fat
T30712	44815-44819	NN	denotes	mass
T30713	44823-44831	JJ	denotes	abnormal
T30714	44832-44834	IN	denotes	in
T30715	44835-44838	DT	denotes	the
T30716	44849-44853	NNS	denotes	mice
T30717	44839-44842	NN	denotes	PGC
T30718	44843-44845	NN	denotes	1α
T30719	44842-44843	HYPH	denotes	-
T30720	44845-44846	SYM	denotes	−
T30721	44846-44847	HYPH	denotes	/
T30722	44847-44848	SYM	denotes	−
T30723	44853-44854	.	denotes	.
T30724	44854-44995	sentence	denotes	Finally, PGC-1α−/− mice do not respond normally to a variety of physiologic and dietary stresses known to increase oxidative energy demands.
T30725	44855-44862	RB	denotes	Finally
T30726	44886-44893	VB	denotes	respond
T30727	44862-44864	,	denotes	,
T30728	44864-44867	NN	denotes	PGC
T30729	44868-44870	NN	denotes	1α
T30730	44867-44868	HYPH	denotes	-
T30731	44874-44878	NNS	denotes	mice
T30732	44870-44871	SYM	denotes	−
T30733	44871-44872	HYPH	denotes	/
T30734	44872-44873	SYM	denotes	−
T30735	44879-44881	VBP	denotes	do
T30736	44882-44885	RB	denotes	not
T30737	44894-44902	RB	denotes	normally
T30738	44903-44905	IN	denotes	to
T30739	44906-44907	DT	denotes	a
T30740	44908-44915	NN	denotes	variety
T30741	44916-44918	IN	denotes	of
T30742	44919-44930	JJ	denotes	physiologic
T30743	44943-44951	NNS	denotes	stresses
T30744	44931-44934	CC	denotes	and
T30745	44935-44942	JJ	denotes	dietary
T30746	44952-44957	VBN	denotes	known
T30747	44958-44960	TO	denotes	to
T30748	44961-44969	VB	denotes	increase
T30749	44970-44979	JJ	denotes	oxidative
T30750	44987-44994	NNS	denotes	demands
T30751	44980-44986	NN	denotes	energy
T30752	44994-44995	.	denotes	.
T30753	44995-45186	sentence	denotes	Taken together, these results strongly suggest that PGC-1α is necessary for the terminal stages of mitochondrial maturation necessary to meet the energy demands of the postnatal environment.
T30754	44996-45001	VBN	denotes	Taken
T30755	45035-45042	VBP	denotes	suggest
T30756	45002-45010	RB	denotes	together
T30757	45010-45012	,	denotes	,
T30758	45012-45017	DT	denotes	these
T30759	45018-45025	NNS	denotes	results
T30760	45026-45034	RB	denotes	strongly
T30761	45043-45047	IN	denotes	that
T30762	45055-45057	VBZ	denotes	is
T30763	45048-45051	NN	denotes	PGC
T30764	45052-45054	NN	denotes	1α
T30765	45051-45052	HYPH	denotes	-
T30766	45058-45067	JJ	denotes	necessary
T30767	45068-45071	IN	denotes	for
T30768	45072-45075	DT	denotes	the
T30769	45085-45091	NNS	denotes	stages
T30770	45076-45084	JJ	denotes	terminal
T30771	45092-45094	IN	denotes	of
T30772	45095-45108	JJ	denotes	mitochondrial
T30773	45109-45119	NN	denotes	maturation
T30774	45120-45129	JJ	denotes	necessary
T30775	45130-45132	TO	denotes	to
T30776	45133-45137	VB	denotes	meet
T30777	45138-45141	DT	denotes	the
T30778	45149-45156	NNS	denotes	demands
T30779	45142-45148	NN	denotes	energy
T30780	45157-45159	IN	denotes	of
T30781	45160-45163	DT	denotes	the
T30782	45174-45185	NN	denotes	environment
T30783	45164-45173	JJ	denotes	postnatal
T30784	45185-45186	.	denotes	.
T30785	45186-45332	sentence	denotes	Extensive phenotypic analyses demonstrated that mice lacking PGC-1α are unable to cope with physiologic stressors relevant to postnatal survival.
T30786	45187-45196	JJ	denotes	Extensive
T30787	45208-45216	NNS	denotes	analyses
T30788	45197-45207	JJ	denotes	phenotypic
T30789	45217-45229	VBD	denotes	demonstrated
T30790	45230-45234	IN	denotes	that
T30791	45255-45258	VBP	denotes	are
T30792	45235-45239	NNS	denotes	mice
T30793	45240-45247	VBG	denotes	lacking
T30794	45248-45251	NN	denotes	PGC
T30795	45252-45254	NN	denotes	1α
T30796	45251-45252	HYPH	denotes	-
T30797	45259-45265	JJ	denotes	unable
T30798	45266-45268	TO	denotes	to
T30799	45269-45273	VB	denotes	cope
T30800	45274-45278	IN	denotes	with
T30801	45279-45290	JJ	denotes	physiologic
T30802	45291-45300	NNS	denotes	stressors
T30803	45301-45309	JJ	denotes	relevant
T30804	45310-45312	IN	denotes	to
T30805	45313-45322	JJ	denotes	postnatal
T30806	45323-45331	NN	denotes	survival
T30807	45331-45332	.	denotes	.
T30808	45332-45462	sentence	denotes	For example, a skeletal muscle phenotype was unveiled in PGC-1α−/− mice under conditions in which energy supply becomes limiting.
T30809	45333-45336	IN	denotes	For
T30810	45378-45386	VBN	denotes	unveiled
T30811	45337-45344	NN	denotes	example
T30812	45344-45346	,	denotes	,
T30813	45346-45347	DT	denotes	a
T30814	45364-45373	NN	denotes	phenotype
T30815	45348-45356	JJ	denotes	skeletal
T30816	45357-45363	NN	denotes	muscle
T30817	45374-45377	VBD	denotes	was
T30818	45387-45389	IN	denotes	in
T30819	45390-45393	NN	denotes	PGC
T30820	45394-45396	NN	denotes	1α
T30821	45393-45394	HYPH	denotes	-
T30822	45400-45404	NNS	denotes	mice
T30823	45396-45397	SYM	denotes	−
T30824	45397-45398	HYPH	denotes	/
T30825	45398-45399	SYM	denotes	−
T30826	45405-45410	IN	denotes	under
T30827	45411-45421	NNS	denotes	conditions
T30828	45422-45424	IN	denotes	in
T30829	45445-45452	VBZ	denotes	becomes
T30830	45425-45430	WDT	denotes	which
T30831	45431-45437	NN	denotes	energy
T30832	45438-45444	NN	denotes	supply
T30833	45453-45461	JJ	denotes	limiting
T30834	45461-45462	.	denotes	.
T30835	45462-45626	sentence	denotes	This was most clearly demonstrated by the profound abnormalities exhibited by PGC-1α−/− mice with exercise-to-exhaustion and repetitive muscle stimulation studies.
T30836	45463-45467	DT	denotes	This
T30837	45485-45497	VBN	denotes	demonstrated
T30838	45468-45471	VBD	denotes	was
T30839	45472-45476	RBS	denotes	most
T30840	45477-45484	RB	denotes	clearly
T30841	45498-45500	IN	denotes	by
T30842	45501-45504	DT	denotes	the
T30843	45514-45527	NNS	denotes	abnormalities
T30844	45505-45513	JJ	denotes	profound
T30845	45528-45537	VBN	denotes	exhibited
T30846	45538-45540	IN	denotes	by
T30847	45541-45544	NN	denotes	PGC
T30848	45545-45547	NN	denotes	1α
T30849	45544-45545	HYPH	denotes	-
T30850	45551-45555	NNS	denotes	mice
T30851	45547-45548	SYM	denotes	−
T30852	45548-45549	HYPH	denotes	/
T30853	45549-45550	SYM	denotes	−
T30854	45556-45560	IN	denotes	with
T30855	45561-45569	NN	denotes	exercise
T30856	45618-45625	NNS	denotes	studies
T30857	45569-45570	HYPH	denotes	-
T30858	45570-45572	IN	denotes	to
T30859	45572-45573	HYPH	denotes	-
T30860	45573-45583	NN	denotes	exhaustion
T30861	45584-45587	CC	denotes	and
T30862	45588-45598	JJ	denotes	repetitive
T30863	45606-45617	NN	denotes	stimulation
T30864	45599-45605	NN	denotes	muscle
T30865	45625-45626	.	denotes	.
T30866	45626-45718	sentence	denotes	Similarly, cardiac performance of PGC-1α−/− mice was compromised following severe exertion.
T30867	45627-45636	RB	denotes	Similarly
T30868	45680-45691	VBN	denotes	compromised
T30869	45636-45638	,	denotes	,
T30870	45638-45645	JJ	denotes	cardiac
T30871	45646-45657	NN	denotes	performance
T30872	45658-45660	IN	denotes	of
T30873	45661-45664	NN	denotes	PGC
T30874	45665-45667	NN	denotes	1α
T30875	45664-45665	HYPH	denotes	-
T30876	45671-45675	NNS	denotes	mice
T30877	45667-45668	SYM	denotes	−
T30878	45668-45669	HYPH	denotes	/
T30879	45669-45670	SYM	denotes	−
T30880	45676-45679	VBD	denotes	was
T30881	45692-45701	VBG	denotes	following
T30882	45702-45708	JJ	denotes	severe
T30883	45709-45717	NN	denotes	exertion
T30884	45717-45718	.	denotes	.
T30885	45718-45782	sentence	denotes	This effect was largely due to an abnormal heart rate response.
T30886	45719-45723	DT	denotes	This
T30887	45724-45730	NN	denotes	effect
T30888	45731-45734	VBD	denotes	was
T30889	45735-45742	RB	denotes	largely
T30890	45743-45746	IN	denotes	due
T30891	45747-45749	IN	denotes	to
T30892	45750-45752	DT	denotes	an
T30893	45773-45781	NN	denotes	response
T30894	45753-45761	JJ	denotes	abnormal
T30895	45762-45767	NN	denotes	heart
T30896	45768-45772	NN	denotes	rate
T30897	45781-45782	.	denotes	.
T30898	45782-46056	sentence	denotes	The basis for the observed abnormalities of cardiac heart rate, including a blunted response to β-adrenergic stimulation, is unknown, but could be related to the effects of late-stage growth arrest and corresponding derangements in energy metabolism on sinus node function.
T30899	45783-45786	DT	denotes	The
T30900	45787-45792	NN	denotes	basis
T30901	45905-45907	VBZ	denotes	is
T30902	45793-45796	IN	denotes	for
T30903	45797-45800	DT	denotes	the
T30904	45810-45823	NNS	denotes	abnormalities
T30905	45801-45809	VBN	denotes	observed
T30906	45824-45826	IN	denotes	of
T30907	45827-45834	JJ	denotes	cardiac
T30908	45841-45845	NN	denotes	rate
T30909	45835-45840	NN	denotes	heart
T30910	45845-45847	,	denotes	,
T30911	45847-45856	VBG	denotes	including
T30912	45857-45858	DT	denotes	a
T30913	45867-45875	NN	denotes	response
T30914	45859-45866	JJ	denotes	blunted
T30915	45876-45878	IN	denotes	to
T30916	45879-45880	NN	denotes	β
T30917	45881-45891	JJ	denotes	adrenergic
T30918	45880-45881	HYPH	denotes	-
T30919	45892-45903	NN	denotes	stimulation
T30920	45903-45905	,	denotes	,
T30921	45908-45915	JJ	denotes	unknown
T30922	45915-45917	,	denotes	,
T30923	45917-45920	CC	denotes	but
T30924	45921-45926	MD	denotes	could
T30925	45927-45929	VB	denotes	be
T30926	45930-45937	JJ	denotes	related
T30927	45938-45940	IN	denotes	to
T30928	45941-45944	DT	denotes	the
T30929	45945-45952	NNS	denotes	effects
T30930	45953-45955	IN	denotes	of
T30931	45956-45960	JJ	denotes	late
T30932	45961-45966	NN	denotes	stage
T30933	45960-45961	HYPH	denotes	-
T30934	45974-45980	NN	denotes	arrest
T30935	45967-45973	NN	denotes	growth
T30936	45981-45984	CC	denotes	and
T30937	45985-45998	JJ	denotes	corresponding
T30938	45999-46011	NNS	denotes	derangements
T30939	46012-46014	IN	denotes	in
T30940	46015-46021	NN	denotes	energy
T30941	46022-46032	NN	denotes	metabolism
T30942	46033-46035	IN	denotes	on
T30943	46036-46041	NN	denotes	sinus
T30944	46042-46046	NN	denotes	node
T30945	46047-46055	NN	denotes	function
T30946	46055-46056	.	denotes	.
T30947	46056-46113	sentence	denotes	PGC-1α was first identified as a coactivator in BAT [2].
T30948	46057-46060	NN	denotes	PGC
T30949	46061-46063	NN	denotes	1α
T30950	46060-46061	HYPH	denotes	-
T30951	46074-46084	VBN	denotes	identified
T30952	46064-46067	VBD	denotes	was
T30953	46068-46073	RB	denotes	first
T30954	46085-46087	IN	denotes	as
T30955	46088-46089	DT	denotes	a
T30956	46090-46101	NN	denotes	coactivator
T30957	46102-46104	IN	denotes	in
T30958	46105-46108	NN	denotes	BAT
T30959	46109-46110	-LRB-	denotes	[
T30960	46110-46111	CD	denotes	2
T30961	46111-46112	-RRB-	denotes	]
T30962	46112-46113	.	denotes	.
T30963	46113-46366	sentence	denotes	Indeed, we found that exposure of the PGC-1α−/− mice to cold, another relevant physiologic stress, resulted in an untoward drop in core body temperature consistent with an abnormality in thermogenesis despite normal cold induction of UCP-1 mRNA in BAT.
T30964	46114-46120	RB	denotes	Indeed
T30965	46125-46130	VBD	denotes	found
T30966	46120-46122	,	denotes	,
T30967	46122-46124	PRP	denotes	we
T30968	46131-46135	IN	denotes	that
T30969	46213-46221	VBD	denotes	resulted
T30970	46136-46144	NN	denotes	exposure
T30971	46145-46147	IN	denotes	of
T30972	46148-46151	DT	denotes	the
T30973	46162-46166	NNS	denotes	mice
T30974	46152-46155	NN	denotes	PGC
T30975	46156-46158	NN	denotes	1α
T30976	46155-46156	HYPH	denotes	-
T30977	46158-46159	SYM	denotes	−
T30978	46159-46160	HYPH	denotes	/
T30979	46160-46161	SYM	denotes	−
T30980	46167-46169	IN	denotes	to
T30981	46170-46174	NN	denotes	cold
T30982	46174-46176	,	denotes	,
T30983	46176-46183	DT	denotes	another
T30984	46205-46211	NN	denotes	stress
T30985	46184-46192	JJ	denotes	relevant
T30986	46193-46204	JJ	denotes	physiologic
T30987	46211-46213	,	denotes	,
T30988	46222-46224	IN	denotes	in
T30989	46225-46227	DT	denotes	an
T30990	46237-46241	NN	denotes	drop
T30991	46228-46236	JJ	denotes	untoward
T30992	46242-46244	IN	denotes	in
T30993	46245-46249	NN	denotes	core
T30994	46255-46266	NN	denotes	temperature
T30995	46250-46254	NN	denotes	body
T30996	46267-46277	JJ	denotes	consistent
T30997	46278-46282	IN	denotes	with
T30998	46283-46285	DT	denotes	an
T30999	46286-46297	NN	denotes	abnormality
T31000	46298-46300	IN	denotes	in
T31001	46301-46314	NN	denotes	thermogenesis
T31002	46315-46322	IN	denotes	despite
T31003	46323-46329	JJ	denotes	normal
T31004	46335-46344	NN	denotes	induction
T31005	46330-46334	NN	denotes	cold
T31006	46345-46347	IN	denotes	of
T31007	46348-46351	NN	denotes	UCP
T31008	46354-46358	NN	denotes	mRNA
T31009	46351-46352	HYPH	denotes	-
T31010	46352-46353	CD	denotes	1
T31011	46359-46361	IN	denotes	in
T31012	46362-46365	NN	denotes	BAT
T31013	46365-46366	.	denotes	.
T31014	46366-46506	sentence	denotes	Studies with a β3-adrenergic agonist confirmed that the peak oxygen consumption rate in thermogenic tissue is diminished in PGC-1α−/− mice.
T31015	46367-46374	NNS	denotes	Studies
T31016	46404-46413	VBD	denotes	confirmed
T31017	46375-46379	IN	denotes	with
T31018	46380-46381	DT	denotes	a
T31019	46396-46403	NN	denotes	agonist
T31020	46382-46384	NN	denotes	β3
T31021	46385-46395	JJ	denotes	adrenergic
T31022	46384-46385	HYPH	denotes	-
T31023	46414-46418	IN	denotes	that
T31024	46477-46487	VBN	denotes	diminished
T31025	46419-46422	DT	denotes	the
T31026	46447-46451	NN	denotes	rate
T31027	46423-46427	JJ	denotes	peak
T31028	46428-46434	NN	denotes	oxygen
T31029	46435-46446	NN	denotes	consumption
T31030	46452-46454	IN	denotes	in
T31031	46455-46466	JJ	denotes	thermogenic
T31032	46467-46473	NN	denotes	tissue
T31033	46474-46476	VBZ	denotes	is
T31034	46488-46490	IN	denotes	in
T31035	46491-46494	NN	denotes	PGC
T31036	46495-46497	NN	denotes	1α
T31037	46494-46495	HYPH	denotes	-
T31038	46501-46505	NNS	denotes	mice
T31039	46497-46498	SYM	denotes	−
T31040	46498-46499	HYPH	denotes	/
T31041	46499-46500	SYM	denotes	−
T31042	46505-46506	.	denotes	.
T31043	46506-46617	sentence	denotes	We propose that the thermogenic phenotype is related to reduced capacity for mitochondrial respiration in BAT.
T31044	46507-46509	PRP	denotes	We
T31045	46510-46517	VBP	denotes	propose
T31046	46518-46522	IN	denotes	that
T31047	46552-46559	VBN	denotes	related
T31048	46523-46526	DT	denotes	the
T31049	46539-46548	NN	denotes	phenotype
T31050	46527-46538	JJ	denotes	thermogenic
T31051	46549-46551	VBZ	denotes	is
T31052	46560-46562	IN	denotes	to
T31053	46563-46570	VBN	denotes	reduced
T31054	46571-46579	NN	denotes	capacity
T31055	46580-46583	IN	denotes	for
T31056	46584-46597	JJ	denotes	mitochondrial
T31057	46598-46609	NN	denotes	respiration
T31058	46610-46612	IN	denotes	in
T31059	46613-46616	NN	denotes	BAT
T31060	46616-46617	.	denotes	.
T31061	46617-46713	sentence	denotes	Interestingly, this phenotype was only evident during a rather narrow window of postnatal life.
T31062	46618-46631	RB	denotes	Interestingly
T31063	46648-46651	VBD	denotes	was
T31064	46631-46633	,	denotes	,
T31065	46633-46637	DT	denotes	this
T31066	46638-46647	NN	denotes	phenotype
T31067	46652-46656	RB	denotes	only
T31068	46657-46664	JJ	denotes	evident
T31069	46665-46671	IN	denotes	during
T31070	46672-46673	DT	denotes	a
T31071	46688-46694	NN	denotes	window
T31072	46674-46680	RB	denotes	rather
T31073	46681-46687	JJ	denotes	narrow
T31074	46695-46697	IN	denotes	of
T31075	46698-46707	JJ	denotes	postnatal
T31076	46708-46712	NN	denotes	life
T31077	46712-46713	.	denotes	.
T31078	46713-46837	sentence	denotes	Animals at an older age did not exhibit cold intolerance, possibly due to the insulating properties of increased body mass.
T31079	46714-46721	NNS	denotes	Animals
T31080	46746-46753	VB	denotes	exhibit
T31081	46722-46724	IN	denotes	at
T31082	46725-46727	DT	denotes	an
T31083	46734-46737	NN	denotes	age
T31084	46728-46733	JJR	denotes	older
T31085	46738-46741	VBD	denotes	did
T31086	46742-46745	RB	denotes	not
T31087	46754-46758	NN	denotes	cold
T31088	46759-46770	NN	denotes	intolerance
T31089	46770-46772	,	denotes	,
T31090	46772-46780	RB	denotes	possibly
T31091	46781-46784	IN	denotes	due
T31092	46785-46787	IN	denotes	to
T31093	46788-46791	DT	denotes	the
T31094	46803-46813	NNS	denotes	properties
T31095	46792-46802	VBG	denotes	insulating
T31096	46814-46816	IN	denotes	of
T31097	46817-46826	VBN	denotes	increased
T31098	46832-46836	NN	denotes	mass
T31099	46827-46831	NN	denotes	body
T31100	46836-46837	.	denotes	.
T31101	46837-46982	sentence	denotes	Collectively, these results demonstrate the importance of PGC-1α as a key transducer of physiologic stimuli to the control of energy metabolism.
T31102	46838-46850	RB	denotes	Collectively
T31103	46866-46877	VBP	denotes	demonstrate
T31104	46850-46852	,	denotes	,
T31105	46852-46857	DT	denotes	these
T31106	46858-46865	NNS	denotes	results
T31107	46878-46881	DT	denotes	the
T31108	46882-46892	NN	denotes	importance
T31109	46893-46895	IN	denotes	of
T31110	46896-46899	NN	denotes	PGC
T31111	46900-46902	NN	denotes	1α
T31112	46899-46900	HYPH	denotes	-
T31113	46903-46905	IN	denotes	as
T31114	46906-46907	DT	denotes	a
T31115	46912-46922	NN	denotes	transducer
T31116	46908-46911	JJ	denotes	key
T31117	46923-46925	IN	denotes	of
T31118	46926-46937	JJ	denotes	physiologic
T31119	46938-46945	NNS	denotes	stimuli
T31120	46946-46948	IN	denotes	to
T31121	46949-46952	DT	denotes	the
T31122	46953-46960	NN	denotes	control
T31123	46961-46963	IN	denotes	of
T31124	46964-46970	NN	denotes	energy
T31125	46971-46981	NN	denotes	metabolism
T31126	46981-46982	.	denotes	.
T31127	46982-47146	sentence	denotes	The observation of fasting-induced hepatic steatosis is another example of the inability of PGC-1α−/− mice to respond to postnatal environmental metabolic demands.
T31128	46983-46986	DT	denotes	The
T31129	46987-46998	NN	denotes	observation
T31130	47036-47038	VBZ	denotes	is
T31131	46999-47001	IN	denotes	of
T31132	47002-47009	NN	denotes	fasting
T31133	47010-47017	VBN	denotes	induced
T31134	47009-47010	HYPH	denotes	-
T31135	47026-47035	NN	denotes	steatosis
T31136	47018-47025	JJ	denotes	hepatic
T31137	47039-47046	DT	denotes	another
T31138	47047-47054	NN	denotes	example
T31139	47055-47057	IN	denotes	of
T31140	47058-47061	DT	denotes	the
T31141	47062-47071	NN	denotes	inability
T31142	47072-47074	IN	denotes	of
T31143	47075-47078	NN	denotes	PGC
T31144	47079-47081	NN	denotes	1α
T31145	47078-47079	HYPH	denotes	-
T31146	47085-47089	NNS	denotes	mice
T31147	47081-47082	SYM	denotes	−
T31148	47082-47083	HYPH	denotes	/
T31149	47083-47084	SYM	denotes	−
T31150	47090-47092	TO	denotes	to
T31151	47093-47100	VB	denotes	respond
T31152	47101-47103	IN	denotes	to
T31153	47104-47113	JJ	denotes	postnatal
T31154	47114-47127	JJ	denotes	environmental
T31155	47138-47145	NNS	denotes	demands
T31156	47128-47137	JJ	denotes	metabolic
T31157	47145-47146	.	denotes	.
T31158	47146-47267	sentence	denotes	Following short-term starvation, we found that the PGC-1α−/− mice developed marked hepatocyte triglyceride accumulation.
T31159	47147-47156	VBG	denotes	Following
T31160	47183-47188	VBD	denotes	found
T31161	47157-47162	JJ	denotes	short
T31162	47163-47167	NN	denotes	term
T31163	47162-47163	HYPH	denotes	-
T31164	47168-47178	NN	denotes	starvation
T31165	47178-47180	,	denotes	,
T31166	47180-47182	PRP	denotes	we
T31167	47189-47193	IN	denotes	that
T31168	47213-47222	VBD	denotes	developed
T31169	47194-47197	DT	denotes	the
T31170	47208-47212	NNS	denotes	mice
T31171	47198-47201	NN	denotes	PGC
T31172	47202-47204	NN	denotes	1α
T31173	47201-47202	HYPH	denotes	-
T31174	47204-47205	SYM	denotes	−
T31175	47205-47206	HYPH	denotes	/
T31176	47206-47207	SYM	denotes	−
T31177	47223-47229	JJ	denotes	marked
T31178	47254-47266	NN	denotes	accumulation
T31179	47230-47240	NN	denotes	hepatocyte
T31180	47241-47253	NN	denotes	triglyceride
T31181	47266-47267	.	denotes	.
T31182	47267-47432	sentence	denotes	Further analysis revealed that palmitate oxidation rates were reduced in hepatocytes isolated from the PGC-1α−/− mice, which would predispose to lipid accumulation.
T31183	47268-47275	RB	denotes	Further
T31184	47276-47284	NN	denotes	analysis
T31185	47285-47293	VBD	denotes	revealed
T31186	47294-47298	IN	denotes	that
T31187	47330-47337	VBN	denotes	reduced
T31188	47299-47308	NN	denotes	palmitate
T31189	47309-47318	NN	denotes	oxidation
T31190	47319-47324	NNS	denotes	rates
T31191	47325-47329	VBD	denotes	were
T31192	47338-47340	IN	denotes	in
T31193	47341-47352	NNS	denotes	hepatocytes
T31194	47353-47361	VBN	denotes	isolated
T31195	47362-47366	IN	denotes	from
T31196	47367-47370	DT	denotes	the
T31197	47381-47385	NNS	denotes	mice
T31198	47371-47374	NN	denotes	PGC
T31199	47375-47377	NN	denotes	1α
T31200	47374-47375	HYPH	denotes	-
T31201	47377-47378	SYM	denotes	−
T31202	47378-47379	HYPH	denotes	/
T31203	47379-47380	SYM	denotes	−
T31204	47385-47387	,	denotes	,
T31205	47387-47392	WDT	denotes	which
T31206	47399-47409	VB	denotes	predispose
T31207	47393-47398	MD	denotes	would
T31208	47410-47412	IN	denotes	to
T31209	47413-47418	NN	denotes	lipid
T31210	47419-47431	NN	denotes	accumulation
T31211	47431-47432	.	denotes	.
T31212	47432-47627	sentence	denotes	Surprisingly, the reduction in fatty acid oxidation rates in PGC-1α null hepatocytes was not due to altered expression of PGC-1α/PPAR target genes involved in mitochondrial fatty acid oxidation.
T31213	47433-47445	RB	denotes	Surprisingly
T31214	47518-47521	VBD	denotes	was
T31215	47445-47447	,	denotes	,
T31216	47447-47450	DT	denotes	the
T31217	47451-47460	NN	denotes	reduction
T31218	47461-47463	IN	denotes	in
T31219	47464-47469	JJ	denotes	fatty
T31220	47470-47474	NN	denotes	acid
T31221	47485-47490	NNS	denotes	rates
T31222	47475-47484	NN	denotes	oxidation
T31223	47491-47493	IN	denotes	in
T31224	47494-47497	NN	denotes	PGC
T31225	47498-47500	NN	denotes	1α
T31226	47497-47498	HYPH	denotes	-
T31227	47501-47505	JJ	denotes	null
T31228	47506-47517	NNS	denotes	hepatocytes
T31229	47522-47525	RB	denotes	not
T31230	47526-47529	IN	denotes	due
T31231	47530-47532	IN	denotes	to
T31232	47533-47540	JJ	denotes	altered
T31233	47541-47551	NN	denotes	expression
T31234	47552-47554	IN	denotes	of
T31235	47555-47558	NN	denotes	PGC
T31236	47559-47561	NN	denotes	1α
T31237	47558-47559	HYPH	denotes	-
T31238	47574-47579	NNS	denotes	genes
T31239	47561-47562	HYPH	denotes	/
T31240	47562-47566	NN	denotes	PPAR
T31241	47567-47573	NN	denotes	target
T31242	47580-47588	VBN	denotes	involved
T31243	47589-47591	IN	denotes	in
T31244	47592-47605	JJ	denotes	mitochondrial
T31245	47617-47626	NN	denotes	oxidation
T31246	47606-47611	JJ	denotes	fatty
T31247	47612-47616	NN	denotes	acid
T31248	47626-47627	.	denotes	.
T31249	47627-47685	sentence	denotes	However, mitochondrial respiratory rates were diminished.
T31250	47628-47635	RB	denotes	However
T31251	47674-47684	VBN	denotes	diminished
T31252	47635-47637	,	denotes	,
T31253	47637-47650	JJ	denotes	mitochondrial
T31254	47663-47668	NNS	denotes	rates
T31255	47651-47662	JJ	denotes	respiratory
T31256	47669-47673	VBD	denotes	were
T31257	47684-47685	.	denotes	.
T31258	47685-47933	sentence	denotes	In addition, we found that triglyceride synthesis was abnormally activated, and the expression of genes encoding SREBP-1c and SCD-1, key proteins in the hepatic lipogenic pathway, failed to be appropriately down-regulated in fasted PGC-1α−/− mice.
T31259	47686-47688	IN	denotes	In
T31260	47702-47707	VBD	denotes	found
T31261	47689-47697	NN	denotes	addition
T31262	47697-47699	,	denotes	,
T31263	47699-47701	PRP	denotes	we
T31264	47708-47712	IN	denotes	that
T31265	47751-47760	VBN	denotes	activated
T31266	47713-47725	NN	denotes	triglyceride
T31267	47726-47735	NN	denotes	synthesis
T31268	47736-47739	VBD	denotes	was
T31269	47740-47750	RB	denotes	abnormally
T31270	47760-47762	,	denotes	,
T31271	47762-47765	CC	denotes	and
T31272	47766-47769	DT	denotes	the
T31273	47770-47780	NN	denotes	expression
T31274	47866-47872	VBD	denotes	failed
T31275	47781-47783	IN	denotes	of
T31276	47784-47789	NNS	denotes	genes
T31277	47790-47798	VBG	denotes	encoding
T31278	47799-47804	NN	denotes	SREBP
T31279	47805-47807	NN	denotes	1c
T31280	47804-47805	HYPH	denotes	-
T31281	47808-47811	CC	denotes	and
T31282	47812-47815	NN	denotes	SCD
T31283	47815-47816	HYPH	denotes	-
T31284	47816-47817	CD	denotes	1
T31285	47817-47819	,	denotes	,
T31286	47819-47822	JJ	denotes	key
T31287	47823-47831	NN	denotes	proteins
T31288	47832-47834	IN	denotes	in
T31289	47835-47838	DT	denotes	the
T31290	47857-47864	NN	denotes	pathway
T31291	47839-47846	JJ	denotes	hepatic
T31292	47847-47856	JJ	denotes	lipogenic
T31293	47864-47866	,	denotes	,
T31294	47873-47875	TO	denotes	to
T31295	47898-47907	VBN	denotes	regulated
T31296	47876-47878	VB	denotes	be
T31297	47879-47892	RB	denotes	appropriately
T31298	47893-47897	RB	denotes	down
T31299	47897-47898	HYPH	denotes	-
T31300	47908-47910	IN	denotes	in
T31301	47911-47917	VBN	denotes	fasted
T31302	47928-47932	NNS	denotes	mice
T31303	47918-47921	NN	denotes	PGC
T31304	47922-47924	NN	denotes	1α
T31305	47921-47922	HYPH	denotes	-
T31306	47924-47925	SYM	denotes	−
T31307	47925-47926	HYPH	denotes	/
T31308	47926-47927	SYM	denotes	−
T31309	47932-47933	.	denotes	.
T31310	47933-47991	sentence	denotes	The mechanism involved in this latter finding is unknown.
T31311	47934-47937	DT	denotes	The
T31312	47938-47947	NN	denotes	mechanism
T31313	47980-47982	VBZ	denotes	is
T31314	47948-47956	VBN	denotes	involved
T31315	47957-47959	IN	denotes	in
T31316	47960-47964	DT	denotes	this
T31317	47972-47979	NN	denotes	finding
T31318	47965-47971	JJ	denotes	latter
T31319	47983-47990	JJ	denotes	unknown
T31320	47990-47991	.	denotes	.
T31321	47991-48306	sentence	denotes	Indeed, the relative contribution of increased triglyceride synthesis rates to the steatotic phenotype cannot be fully discerned from our data, given that this response could reflect the direct effects of PGC-1α deficiency on target genes or a secondary compensatory response to hepatocyte fatty acid accumulation.
T31322	47992-47998	RB	denotes	Indeed
T31323	48111-48120	VBN	denotes	discerned
T31324	47998-48000	,	denotes	,
T31325	48000-48003	DT	denotes	the
T31326	48013-48025	NN	denotes	contribution
T31327	48004-48012	JJ	denotes	relative
T31328	48026-48028	IN	denotes	of
T31329	48029-48038	VBN	denotes	increased
T31330	48062-48067	NNS	denotes	rates
T31331	48039-48051	NN	denotes	triglyceride
T31332	48052-48061	NN	denotes	synthesis
T31333	48068-48070	IN	denotes	to
T31334	48071-48074	DT	denotes	the
T31335	48085-48094	NN	denotes	phenotype
T31336	48075-48084	JJ	denotes	steatotic
T31337	48095-48098	MD	denotes	can
T31338	48098-48101	RB	denotes	not
T31339	48102-48104	VB	denotes	be
T31340	48105-48110	RB	denotes	fully
T31341	48121-48125	IN	denotes	from
T31342	48126-48129	PRP$	denotes	our
T31343	48130-48134	NNS	denotes	data
T31344	48134-48136	,	denotes	,
T31345	48136-48141	VBN	denotes	given
T31346	48142-48146	IN	denotes	that
T31347	48167-48174	VB	denotes	reflect
T31348	48147-48151	DT	denotes	this
T31349	48152-48160	NN	denotes	response
T31350	48161-48166	MD	denotes	could
T31351	48175-48178	DT	denotes	the
T31352	48186-48193	NNS	denotes	effects
T31353	48179-48185	JJ	denotes	direct
T31354	48194-48196	IN	denotes	of
T31355	48197-48200	NN	denotes	PGC
T31356	48201-48203	NN	denotes	1α
T31357	48200-48201	HYPH	denotes	-
T31358	48204-48214	NN	denotes	deficiency
T31359	48215-48217	IN	denotes	on
T31360	48218-48224	NN	denotes	target
T31361	48225-48230	NNS	denotes	genes
T31362	48231-48233	CC	denotes	or
T31363	48234-48235	DT	denotes	a
T31364	48259-48267	NN	denotes	response
T31365	48236-48245	JJ	denotes	secondary
T31366	48246-48258	JJ	denotes	compensatory
T31367	48268-48270	IN	denotes	to
T31368	48271-48281	NN	denotes	hepatocyte
T31369	48293-48305	NN	denotes	accumulation
T31370	48282-48287	JJ	denotes	fatty
T31371	48288-48292	NN	denotes	acid
T31372	48305-48306	.	denotes	.
T31373	48306-48499	sentence	denotes	Consistent with the former possibility, recent evidence indicates that PGC-1α coactivates the nuclear receptor FXR, a negative regulator of SREBP-1c expression and triglyceride synthesis [33].
T31374	48307-48317	JJ	denotes	Consistent
T31375	48363-48372	VBZ	denotes	indicates
T31376	48318-48322	IN	denotes	with
T31377	48323-48326	DT	denotes	the
T31378	48334-48345	NN	denotes	possibility
T31379	48327-48333	JJ	denotes	former
T31380	48345-48347	,	denotes	,
T31381	48347-48353	JJ	denotes	recent
T31382	48354-48362	NN	denotes	evidence
T31383	48373-48377	IN	denotes	that
T31384	48385-48396	VBZ	denotes	coactivates
T31385	48378-48381	NN	denotes	PGC
T31386	48382-48384	NN	denotes	1α
T31387	48381-48382	HYPH	denotes	-
T31388	48397-48400	DT	denotes	the
T31389	48409-48417	NN	denotes	receptor
T31390	48401-48408	JJ	denotes	nuclear
T31391	48418-48421	NN	denotes	FXR
T31392	48421-48423	,	denotes	,
T31393	48423-48424	DT	denotes	a
T31394	48434-48443	NN	denotes	regulator
T31395	48425-48433	JJ	denotes	negative
T31396	48444-48446	IN	denotes	of
T31397	48447-48452	NN	denotes	SREBP
T31398	48453-48455	NN	denotes	1c
T31399	48452-48453	HYPH	denotes	-
T31400	48456-48466	NN	denotes	expression
T31401	48467-48470	CC	denotes	and
T31402	48471-48483	NN	denotes	triglyceride
T31403	48484-48493	NN	denotes	synthesis
T31404	48494-48495	-LRB-	denotes	[
T31405	48495-48497	CD	denotes	33
T31406	48497-48498	-RRB-	denotes	]
T31407	48498-48499	.	denotes	.
T31408	48499-48754	sentence	denotes	We conclude that reduced hepatocyte mitochondrial respiratory capacity, and possibly activation of lipogenic programs, result in hepatocyte triglyceride accumulation in the context of increased hepatic delivery of fatty acids such as occurs with fasting.
T31409	48500-48502	PRP	denotes	We
T31410	48503-48511	VBP	denotes	conclude
T31411	48512-48516	IN	denotes	that
T31412	48619-48625	VBP	denotes	result
T31413	48517-48524	VBN	denotes	reduced
T31414	48562-48570	NN	denotes	capacity
T31415	48525-48535	NN	denotes	hepatocyte
T31416	48536-48549	JJ	denotes	mitochondrial
T31417	48550-48561	JJ	denotes	respiratory
T31418	48570-48572	,	denotes	,
T31419	48572-48575	CC	denotes	and
T31420	48576-48584	RB	denotes	possibly
T31421	48585-48595	NN	denotes	activation
T31422	48596-48598	IN	denotes	of
T31423	48599-48608	JJ	denotes	lipogenic
T31424	48609-48617	NNS	denotes	programs
T31425	48617-48619	,	denotes	,
T31426	48626-48628	IN	denotes	in
T31427	48629-48639	NN	denotes	hepatocyte
T31428	48640-48652	NN	denotes	triglyceride
T31429	48653-48665	NN	denotes	accumulation
T31430	48666-48668	IN	denotes	in
T31431	48669-48672	DT	denotes	the
T31432	48673-48680	NN	denotes	context
T31433	48681-48683	IN	denotes	of
T31434	48684-48693	VBN	denotes	increased
T31435	48702-48710	NN	denotes	delivery
T31436	48694-48701	JJ	denotes	hepatic
T31437	48711-48713	IN	denotes	of
T31438	48714-48719	JJ	denotes	fatty
T31439	48720-48725	NNS	denotes	acids
T31440	48726-48730	JJ	denotes	such
T31441	48731-48733	IN	denotes	as
T31442	48734-48740	VBZ	denotes	occurs
T31443	48741-48745	IN	denotes	with
T31444	48746-48753	NN	denotes	fasting
T31445	48753-48754	.	denotes	.
T31446	48754-48906	sentence	denotes	We found that after 18 wk of age, female PGC-1α−/− mice exhibit a mild but significantly abnormal weight increase associated with increased fat stores.
T31447	48755-48757	PRP	denotes	We
T31448	48758-48763	VBD	denotes	found
T31449	48764-48768	IN	denotes	that
T31450	48811-48818	VBP	denotes	exhibit
T31451	48769-48774	IN	denotes	after
T31452	48775-48777	CD	denotes	18
T31453	48778-48780	NN	denotes	wk
T31454	48781-48783	IN	denotes	of
T31455	48784-48787	NN	denotes	age
T31456	48787-48789	,	denotes	,
T31457	48789-48795	JJ	denotes	female
T31458	48806-48810	NNS	denotes	mice
T31459	48796-48799	NN	denotes	PGC
T31460	48800-48802	NN	denotes	1α
T31461	48799-48800	HYPH	denotes	-
T31462	48802-48803	SYM	denotes	−
T31463	48803-48804	HYPH	denotes	/
T31464	48804-48805	SYM	denotes	−
T31465	48819-48820	DT	denotes	a
T31466	48860-48868	NN	denotes	increase
T31467	48821-48825	JJ	denotes	mild
T31468	48826-48829	CC	denotes	but
T31469	48830-48843	RB	denotes	significantly
T31470	48844-48852	JJ	denotes	abnormal
T31471	48853-48859	NN	denotes	weight
T31472	48869-48879	VBN	denotes	associated
T31473	48880-48884	IN	denotes	with
T31474	48885-48894	VBN	denotes	increased
T31475	48899-48905	NNS	denotes	stores
T31476	48895-48898	NN	denotes	fat
T31477	48905-48906	.	denotes	.
T31478	48906-48959	sentence	denotes	Lean mass was unchanged at the time points examined.
T31479	48907-48911	JJ	denotes	Lean
T31480	48912-48916	NN	denotes	mass
T31481	48917-48920	VBD	denotes	was
T31482	48921-48930	JJ	denotes	unchanged
T31483	48931-48933	IN	denotes	at
T31484	48934-48937	DT	denotes	the
T31485	48943-48949	NNS	denotes	points
T31486	48938-48942	NN	denotes	time
T31487	48950-48958	VBN	denotes	examined
T31488	48958-48959	.	denotes	.
T31489	48959-49083	sentence	denotes	With further aging, a modest but significant increase in body fat was also noted in male PGC-1α−/− mice (unpublished data).
T31490	48960-48964	IN	denotes	With
T31491	49035-49040	VBN	denotes	noted
T31492	48965-48972	JJ	denotes	further
T31493	48973-48978	NN	denotes	aging
T31494	48978-48980	,	denotes	,
T31495	48980-48981	DT	denotes	a
T31496	49005-49013	NN	denotes	increase
T31497	48982-48988	JJ	denotes	modest
T31498	48989-48992	CC	denotes	but
T31499	48993-49004	JJ	denotes	significant
T31500	49014-49016	IN	denotes	in
T31501	49017-49021	NN	denotes	body
T31502	49022-49025	NN	denotes	fat
T31503	49026-49029	VBD	denotes	was
T31504	49030-49034	RB	denotes	also
T31505	49041-49043	IN	denotes	in
T31506	49044-49048	JJ	denotes	male
T31507	49059-49063	NNS	denotes	mice
T31508	49049-49052	NN	denotes	PGC
T31509	49053-49055	NN	denotes	1α
T31510	49052-49053	HYPH	denotes	-
T31511	49055-49056	SYM	denotes	−
T31512	49056-49057	HYPH	denotes	/
T31513	49057-49058	SYM	denotes	−
T31514	49064-49065	-LRB-	denotes	(
T31515	49077-49081	NNS	denotes	data
T31516	49065-49076	JJ	denotes	unpublished
T31517	49081-49082	-RRB-	denotes	)
T31518	49082-49083	.	denotes	.
T31519	49083-49154	sentence	denotes	The basis for the observed abnormalities in weight control is unknown.
T31520	49084-49087	DT	denotes	The
T31521	49088-49093	NN	denotes	basis
T31522	49143-49145	VBZ	denotes	is
T31523	49094-49097	IN	denotes	for
T31524	49098-49101	DT	denotes	the
T31525	49111-49124	NNS	denotes	abnormalities
T31526	49102-49110	VBN	denotes	observed
T31527	49125-49127	IN	denotes	in
T31528	49128-49134	NN	denotes	weight
T31529	49135-49142	NN	denotes	control
T31530	49146-49153	JJ	denotes	unknown
T31531	49153-49154	.	denotes	.
T31532	49154-49242	sentence	denotes	We did not find differences in food intake or activity levels in female PGC-1α−/− mice.
T31533	49155-49157	PRP	denotes	We
T31534	49166-49170	VB	denotes	find
T31535	49158-49161	VBD	denotes	did
T31536	49162-49165	RB	denotes	not
T31537	49171-49182	NNS	denotes	differences
T31538	49183-49185	IN	denotes	in
T31539	49186-49190	NN	denotes	food
T31540	49191-49197	NN	denotes	intake
T31541	49198-49200	CC	denotes	or
T31542	49201-49209	NN	denotes	activity
T31543	49210-49216	NNS	denotes	levels
T31544	49217-49219	IN	denotes	in
T31545	49220-49226	JJ	denotes	female
T31546	49237-49241	NNS	denotes	mice
T31547	49227-49230	NN	denotes	PGC
T31548	49231-49233	NN	denotes	1α
T31549	49230-49231	HYPH	denotes	-
T31550	49233-49234	SYM	denotes	−
T31551	49234-49235	HYPH	denotes	/
T31552	49235-49236	SYM	denotes	−
T31553	49241-49242	.	denotes	.
T31554	49242-49415	sentence	denotes	It is possible that a reduction in systemic energy utilization, related to the mitochondrial dysfunction, leads to increased fat mass and weight gain in the PGC-1α−/− mice.
T31555	49243-49245	PRP	denotes	It
T31556	49246-49248	VBZ	denotes	is
T31557	49249-49257	JJ	denotes	possible
T31558	49258-49262	IN	denotes	that
T31559	49349-49354	VBZ	denotes	leads
T31560	49263-49264	DT	denotes	a
T31561	49265-49274	NN	denotes	reduction
T31562	49275-49277	IN	denotes	in
T31563	49278-49286	JJ	denotes	systemic
T31564	49294-49305	NN	denotes	utilization
T31565	49287-49293	NN	denotes	energy
T31566	49305-49307	,	denotes	,
T31567	49307-49314	VBN	denotes	related
T31568	49315-49317	IN	denotes	to
T31569	49318-49321	DT	denotes	the
T31570	49336-49347	NN	denotes	dysfunction
T31571	49322-49335	JJ	denotes	mitochondrial
T31572	49347-49349	,	denotes	,
T31573	49355-49357	IN	denotes	to
T31574	49358-49367	VBN	denotes	increased
T31575	49372-49376	NN	denotes	mass
T31576	49368-49371	NN	denotes	fat
T31577	49377-49380	CC	denotes	and
T31578	49381-49387	NN	denotes	weight
T31579	49388-49392	NN	denotes	gain
T31580	49393-49395	IN	denotes	in
T31581	49396-49399	DT	denotes	the
T31582	49410-49414	NNS	denotes	mice
T31583	49400-49403	NN	denotes	PGC
T31584	49404-49406	NN	denotes	1α
T31585	49403-49404	HYPH	denotes	-
T31586	49406-49407	SYM	denotes	−
T31587	49407-49408	HYPH	denotes	/
T31588	49408-49409	SYM	denotes	−
T31589	49414-49415	.	denotes	.
T31590	49415-49534	sentence	denotes	Interestingly, an association between PGC-1α gene polymorphisms and obesity in humans has been recently reported [26].
T31591	49416-49429	RB	denotes	Interestingly
T31592	49520-49528	VBN	denotes	reported
T31593	49429-49431	,	denotes	,
T31594	49431-49433	DT	denotes	an
T31595	49434-49445	NN	denotes	association
T31596	49446-49453	IN	denotes	between
T31597	49454-49457	NN	denotes	PGC
T31598	49458-49460	NN	denotes	1α
T31599	49457-49458	HYPH	denotes	-
T31600	49466-49479	NNS	denotes	polymorphisms
T31601	49461-49465	NN	denotes	gene
T31602	49480-49483	CC	denotes	and
T31603	49484-49491	NN	denotes	obesity
T31604	49492-49494	IN	denotes	in
T31605	49495-49501	NNS	denotes	humans
T31606	49502-49505	VBZ	denotes	has
T31607	49506-49510	VBN	denotes	been
T31608	49511-49519	RB	denotes	recently
T31609	49529-49530	-LRB-	denotes	[
T31610	49530-49532	CD	denotes	26
T31611	49532-49533	-RRB-	denotes	]
T31612	49533-49534	.	denotes	.
T31613	49534-49746	sentence	denotes	Clearly, future studies of male and female PGC-1α−/− mice in pure-strain backgrounds over a range of ages will be necessary to fully investigate the observed abnormalities in weight control and fat distribution.
T31614	49535-49542	RB	denotes	Clearly
T31615	49646-49648	VB	denotes	be
T31616	49542-49544	,	denotes	,
T31617	49544-49550	JJ	denotes	future
T31618	49551-49558	NNS	denotes	studies
T31619	49559-49561	IN	denotes	of
T31620	49562-49566	JJ	denotes	male
T31621	49588-49592	NNS	denotes	mice
T31622	49567-49570	CC	denotes	and
T31623	49571-49577	JJ	denotes	female
T31624	49578-49581	NN	denotes	PGC
T31625	49582-49584	NN	denotes	1α
T31626	49581-49582	HYPH	denotes	-
T31627	49584-49585	SYM	denotes	−
T31628	49585-49586	HYPH	denotes	/
T31629	49586-49587	SYM	denotes	−
T31630	49593-49595	IN	denotes	in
T31631	49596-49600	JJ	denotes	pure
T31632	49601-49607	NN	denotes	strain
T31633	49600-49601	HYPH	denotes	-
T31634	49608-49619	NNS	denotes	backgrounds
T31635	49620-49624	IN	denotes	over
T31636	49625-49626	DT	denotes	a
T31637	49627-49632	NN	denotes	range
T31638	49633-49635	IN	denotes	of
T31639	49636-49640	NNS	denotes	ages
T31640	49641-49645	MD	denotes	will
T31641	49649-49658	JJ	denotes	necessary
T31642	49659-49661	TO	denotes	to
T31643	49668-49679	VB	denotes	investigate
T31644	49662-49667	RB	denotes	fully
T31645	49680-49683	DT	denotes	the
T31646	49693-49706	NNS	denotes	abnormalities
T31647	49684-49692	VBN	denotes	observed
T31648	49707-49709	IN	denotes	in
T31649	49710-49716	NN	denotes	weight
T31650	49717-49724	NN	denotes	control
T31651	49725-49728	CC	denotes	and
T31652	49729-49732	NN	denotes	fat
T31653	49733-49745	NN	denotes	distribution
T31654	49745-49746	.	denotes	.
T31655	49746-49860	sentence	denotes	We did not find evidence for glucose intolerance or insulin resistance in the PGC-1α−/− animals on standard chow.
T31656	49747-49749	PRP	denotes	We
T31657	49758-49762	VB	denotes	find
T31658	49750-49753	VBD	denotes	did
T31659	49754-49757	RB	denotes	not
T31660	49763-49771	NN	denotes	evidence
T31661	49772-49775	IN	denotes	for
T31662	49776-49783	NN	denotes	glucose
T31663	49784-49795	NN	denotes	intolerance
T31664	49796-49798	CC	denotes	or
T31665	49799-49806	NN	denotes	insulin
T31666	49807-49817	NN	denotes	resistance
T31667	49818-49820	IN	denotes	in
T31668	49821-49824	DT	denotes	the
T31669	49835-49842	NNS	denotes	animals
T31670	49825-49828	NN	denotes	PGC
T31671	49829-49831	NN	denotes	1α
T31672	49828-49829	HYPH	denotes	-
T31673	49831-49832	SYM	denotes	−
T31674	49832-49833	HYPH	denotes	/
T31675	49833-49834	SYM	denotes	−
T31676	49843-49845	IN	denotes	on
T31677	49846-49854	JJ	denotes	standard
T31678	49855-49859	NN	denotes	chow
T31679	49859-49860	.	denotes	.
T31680	49860-49997	sentence	denotes	Moreover, female PGC-1α−/− mice were more glucose-tolerant and insulin-sensitive than PGC-1α+/+ controls when consuming a high-fat diet.
T31681	49861-49869	RB	denotes	Moreover
T31682	49893-49897	VBD	denotes	were
T31683	49869-49871	,	denotes	,
T31684	49871-49877	JJ	denotes	female
T31685	49888-49892	NNS	denotes	mice
T31686	49878-49881	NN	denotes	PGC
T31687	49882-49884	NN	denotes	1α
T31688	49881-49882	HYPH	denotes	-
T31689	49884-49885	SYM	denotes	−
T31690	49885-49886	HYPH	denotes	/
T31691	49886-49887	SYM	denotes	−
T31692	49898-49902	RBR	denotes	more
T31693	49911-49919	JJ	denotes	tolerant
T31694	49903-49910	NN	denotes	glucose
T31695	49910-49911	HYPH	denotes	-
T31696	49920-49923	CC	denotes	and
T31697	49924-49931	NN	denotes	insulin
T31698	49932-49941	JJ	denotes	sensitive
T31699	49931-49932	HYPH	denotes	-
T31700	49942-49946	IN	denotes	than
T31701	49947-49950	NN	denotes	PGC
T31702	49951-49953	NN	denotes	1α
T31703	49950-49951	HYPH	denotes	-
T31704	49957-49965	NNS	denotes	controls
T31705	49953-49954	SYM	denotes	+
T31706	49954-49955	HYPH	denotes	/
T31707	49955-49956	SYM	denotes	+
T31708	49966-49970	WRB	denotes	when
T31709	49971-49980	VBG	denotes	consuming
T31710	49981-49982	DT	denotes	a
T31711	49992-49996	NN	denotes	diet
T31712	49983-49987	JJ	denotes	high
T31713	49988-49991	NN	denotes	fat
T31714	49987-49988	HYPH	denotes	-
T31715	49996-49997	.	denotes	.
T31716	49997-50158	sentence	denotes	These findings are surprising, given the results of several recent studies demonstrating reduced expression of PGC-1α in human diabetic skeletal muscle [24,34].
T31717	49998-50003	DT	denotes	These
T31718	50004-50012	NNS	denotes	findings
T31719	50013-50016	VBP	denotes	are
T31720	50017-50027	JJ	denotes	surprising
T31721	50027-50029	,	denotes	,
T31722	50029-50034	VBN	denotes	given
T31723	50035-50038	DT	denotes	the
T31724	50039-50046	NNS	denotes	results
T31725	50047-50049	IN	denotes	of
T31726	50050-50057	JJ	denotes	several
T31727	50065-50072	NNS	denotes	studies
T31728	50058-50064	JJ	denotes	recent
T31729	50073-50086	VBG	denotes	demonstrating
T31730	50087-50094	VBN	denotes	reduced
T31731	50095-50105	NN	denotes	expression
T31732	50106-50108	IN	denotes	of
T31733	50109-50112	NN	denotes	PGC
T31734	50113-50115	NN	denotes	1α
T31735	50112-50113	HYPH	denotes	-
T31736	50116-50118	IN	denotes	in
T31737	50119-50124	JJ	denotes	human
T31738	50143-50149	NN	denotes	muscle
T31739	50125-50133	JJ	denotes	diabetic
T31740	50134-50142	JJ	denotes	skeletal
T31741	50150-50151	-LRB-	denotes	[
T31742	50154-50156	CD	denotes	34
T31743	50151-50153	CD	denotes	24
T31744	50153-50154	,	denotes	,
T31745	50156-50157	-RRB-	denotes	]
T31746	50157-50158	.	denotes	.
T31747	50158-50316	sentence	denotes	It is certainly possible that compensatory metabolic regulatory mechanisms have been activated in the PGC-1α-deficient mice, accounting for this observation.
T31748	50159-50161	PRP	denotes	It
T31749	50162-50164	VBZ	denotes	is
T31750	50165-50174	RB	denotes	certainly
T31751	50175-50183	JJ	denotes	possible
T31752	50184-50188	IN	denotes	that
T31753	50244-50253	VBN	denotes	activated
T31754	50189-50201	JJ	denotes	compensatory
T31755	50223-50233	NNS	denotes	mechanisms
T31756	50202-50211	JJ	denotes	metabolic
T31757	50212-50222	JJ	denotes	regulatory
T31758	50234-50238	VBP	denotes	have
T31759	50239-50243	VBN	denotes	been
T31760	50254-50256	IN	denotes	in
T31761	50257-50260	DT	denotes	the
T31762	50278-50282	NNS	denotes	mice
T31763	50261-50264	NN	denotes	PGC
T31764	50265-50267	NN	denotes	1α
T31765	50264-50265	HYPH	denotes	-
T31766	50268-50277	JJ	denotes	deficient
T31767	50267-50268	HYPH	denotes	-
T31768	50282-50284	,	denotes	,
T31769	50284-50294	VBG	denotes	accounting
T31770	50295-50298	IN	denotes	for
T31771	50299-50303	DT	denotes	this
T31772	50304-50315	NN	denotes	observation
T31773	50315-50316	.	denotes	.
T31774	50316-50424	sentence	denotes	Alternatively, PGC-1α could serve as a coactivator of factors that mediate diet-induced insulin resistance.
T31775	50317-50330	RB	denotes	Alternatively
T31776	50345-50350	VB	denotes	serve
T31777	50330-50332	,	denotes	,
T31778	50332-50335	NN	denotes	PGC
T31779	50336-50338	NN	denotes	1α
T31780	50335-50336	HYPH	denotes	-
T31781	50339-50344	MD	denotes	could
T31782	50351-50353	IN	denotes	as
T31783	50354-50355	DT	denotes	a
T31784	50356-50367	NN	denotes	coactivator
T31785	50368-50370	IN	denotes	of
T31786	50371-50378	NNS	denotes	factors
T31787	50379-50383	WDT	denotes	that
T31788	50384-50391	VBP	denotes	mediate
T31789	50392-50396	NN	denotes	diet
T31790	50397-50404	VBN	denotes	induced
T31791	50396-50397	HYPH	denotes	-
T31792	50413-50423	NN	denotes	resistance
T31793	50405-50412	NN	denotes	insulin
T31794	50423-50424	.	denotes	.
T31795	50424-50586	sentence	denotes	Consistent with this notion, we and others have shown that mice lacking the PGC-1α target PPAR exhibit resistance to diet-induced glucose intolerance [21,35,36].
T31796	50425-50435	JJ	denotes	Consistent
T31797	50473-50478	VBN	denotes	shown
T31798	50436-50440	IN	denotes	with
T31799	50441-50445	DT	denotes	this
T31800	50446-50452	NN	denotes	notion
T31801	50452-50454	,	denotes	,
T31802	50454-50456	PRP	denotes	we
T31803	50457-50460	CC	denotes	and
T31804	50461-50467	NNS	denotes	others
T31805	50468-50472	VBP	denotes	have
T31806	50479-50483	IN	denotes	that
T31807	50520-50527	VBP	denotes	exhibit
T31808	50484-50488	NNS	denotes	mice
T31809	50489-50496	VBG	denotes	lacking
T31810	50497-50500	DT	denotes	the
T31811	50508-50514	NN	denotes	target
T31812	50501-50504	NN	denotes	PGC
T31813	50505-50507	NN	denotes	1α
T31814	50504-50505	HYPH	denotes	-
T31815	50515-50519	NN	denotes	PPAR
T31816	50528-50538	NN	denotes	resistance
T31817	50539-50541	IN	denotes	to
T31818	50542-50546	NN	denotes	diet
T31819	50547-50554	VBN	denotes	induced
T31820	50546-50547	HYPH	denotes	-
T31821	50563-50574	NN	denotes	intolerance
T31822	50555-50562	NN	denotes	glucose
T31823	50575-50576	-LRB-	denotes	[
T31824	50582-50584	CD	denotes	36
T31825	50576-50578	CD	denotes	21
T31826	50578-50579	,	denotes	,
T31827	50579-50581	CD	denotes	35
T31828	50581-50582	,	denotes	,
T31829	50584-50585	-RRB-	denotes	]
T31830	50585-50586	.	denotes	.
T31831	50586-50697	sentence	denotes	Histologic surveys of the PGC-1α−/− mice revealed ultrastructural abnormalities in the central nervous system.
T31832	50587-50597	JJ	denotes	Histologic
T31833	50598-50605	NNS	denotes	surveys
T31834	50628-50636	VBD	denotes	revealed
T31835	50606-50608	IN	denotes	of
T31836	50609-50612	DT	denotes	the
T31837	50623-50627	NNS	denotes	mice
T31838	50613-50616	NN	denotes	PGC
T31839	50617-50619	NN	denotes	1α
T31840	50616-50617	HYPH	denotes	-
T31841	50619-50620	SYM	denotes	−
T31842	50620-50621	HYPH	denotes	/
T31843	50621-50622	SYM	denotes	−
T31844	50637-50652	JJ	denotes	ultrastructural
T31845	50653-50666	NNS	denotes	abnormalities
T31846	50667-50669	IN	denotes	in
T31847	50670-50673	DT	denotes	the
T31848	50690-50696	NN	denotes	system
T31849	50674-50681	JJ	denotes	central
T31850	50682-50689	JJ	denotes	nervous
T31851	50696-50697	.	denotes	.
T31852	50697-50935	sentence	denotes	Inspection of sections prepared from the brains of PGC-1α−/− mice revealed patchy areas of microvacuolation in the pyramidal neurons of the cerebral cortex, accompanied by a mild increase in the number of astrocytes in the basal ganglia.
T31853	50698-50708	NN	denotes	Inspection
T31854	50764-50772	VBD	denotes	revealed
T31855	50709-50711	IN	denotes	of
T31856	50712-50720	NNS	denotes	sections
T31857	50721-50729	VBN	denotes	prepared
T31858	50730-50734	IN	denotes	from
T31859	50735-50738	DT	denotes	the
T31860	50739-50745	NNS	denotes	brains
T31861	50746-50748	IN	denotes	of
T31862	50749-50752	NN	denotes	PGC
T31863	50753-50755	NN	denotes	1α
T31864	50752-50753	HYPH	denotes	-
T31865	50759-50763	NNS	denotes	mice
T31866	50755-50756	SYM	denotes	−
T31867	50756-50757	HYPH	denotes	/
T31868	50757-50758	SYM	denotes	−
T31869	50773-50779	JJ	denotes	patchy
T31870	50780-50785	NNS	denotes	areas
T31871	50786-50788	IN	denotes	of
T31872	50789-50805	NN	denotes	microvacuolation
T31873	50806-50808	IN	denotes	in
T31874	50809-50812	DT	denotes	the
T31875	50823-50830	NNS	denotes	neurons
T31876	50813-50822	JJ	denotes	pyramidal
T31877	50831-50833	IN	denotes	of
T31878	50834-50837	DT	denotes	the
T31879	50847-50853	NN	denotes	cortex
T31880	50838-50846	JJ	denotes	cerebral
T31881	50853-50855	,	denotes	,
T31882	50855-50866	VBN	denotes	accompanied
T31883	50867-50869	IN	denotes	by
T31884	50870-50871	DT	denotes	a
T31885	50877-50885	NN	denotes	increase
T31886	50872-50876	JJ	denotes	mild
T31887	50886-50888	IN	denotes	in
T31888	50889-50892	DT	denotes	the
T31889	50893-50899	NN	denotes	number
T31890	50900-50902	IN	denotes	of
T31891	50903-50913	NNS	denotes	astrocytes
T31892	50914-50916	IN	denotes	in
T31893	50917-50920	DT	denotes	the
T31894	50927-50934	NNS	denotes	ganglia
T31895	50921-50926	JJ	denotes	basal
T31896	50934-50935	.	denotes	.
T31897	50935-51013	sentence	denotes	The basis for this interesting but relatively nonspecific finding is unknown.
T31898	50936-50939	DT	denotes	The
T31899	50940-50945	NN	denotes	basis
T31900	51002-51004	VBZ	denotes	is
T31901	50946-50949	IN	denotes	for
T31902	50950-50954	DT	denotes	this
T31903	50994-51001	NN	denotes	finding
T31904	50955-50966	JJ	denotes	interesting
T31905	50967-50970	CC	denotes	but
T31906	50971-50981	RB	denotes	relatively
T31907	50982-50993	JJ	denotes	nonspecific
T31908	51005-51012	JJ	denotes	unknown
T31909	51012-51013	.	denotes	.
T31910	51013-51115	sentence	denotes	It is possible that PGC-1α plays an important role in lipid metabolism related to membrane synthesis.
T31911	51014-51016	PRP	denotes	It
T31912	51017-51019	VBZ	denotes	is
T31913	51020-51028	JJ	denotes	possible
T31914	51029-51033	IN	denotes	that
T31915	51041-51046	VBZ	denotes	plays
T31916	51034-51037	NN	denotes	PGC
T31917	51038-51040	NN	denotes	1α
T31918	51037-51038	HYPH	denotes	-
T31919	51047-51049	DT	denotes	an
T31920	51060-51064	NN	denotes	role
T31921	51050-51059	JJ	denotes	important
T31922	51065-51067	IN	denotes	in
T31923	51068-51073	NN	denotes	lipid
T31924	51074-51084	NN	denotes	metabolism
T31925	51085-51092	VBN	denotes	related
T31926	51093-51095	IN	denotes	to
T31927	51096-51104	NN	denotes	membrane
T31928	51105-51114	NN	denotes	synthesis
T31929	51114-51115	.	denotes	.
T31930	51115-51287	sentence	denotes	Alternatively, the normal process of cellular debris turnover could be altered due to a defect in the energetics of the microglial component of the central nervous system.
T31931	51116-51129	RB	denotes	Alternatively
T31932	51187-51194	VBN	denotes	altered
T31933	51129-51131	,	denotes	,
T31934	51131-51134	DT	denotes	the
T31935	51142-51149	NN	denotes	process
T31936	51135-51141	JJ	denotes	normal
T31937	51150-51152	IN	denotes	of
T31938	51153-51161	JJ	denotes	cellular
T31939	51162-51168	NN	denotes	debris
T31940	51169-51177	NN	denotes	turnover
T31941	51178-51183	MD	denotes	could
T31942	51184-51186	VB	denotes	be
T31943	51195-51198	IN	denotes	due
T31944	51199-51201	IN	denotes	to
T31945	51202-51203	DT	denotes	a
T31946	51204-51210	NN	denotes	defect
T31947	51211-51213	IN	denotes	in
T31948	51214-51217	DT	denotes	the
T31949	51218-51228	NNS	denotes	energetics
T31950	51229-51231	IN	denotes	of
T31951	51232-51235	DT	denotes	the
T31952	51247-51256	NN	denotes	component
T31953	51236-51246	JJ	denotes	microglial
T31954	51257-51259	IN	denotes	of
T31955	51260-51263	DT	denotes	the
T31956	51280-51286	NN	denotes	system
T31957	51264-51271	JJ	denotes	central
T31958	51272-51279	JJ	denotes	nervous
T31959	51286-51287	.	denotes	.
T31960	51287-51529	sentence	denotes	Although overt neurologic dysfunction was not apparent in PGC-1α−/− mice during the first 6 mo of life (no group differences were found on five of six sensorimotor tests), the PGC-1α−/− mice showed clear deficits on the inverted screen test.
T31961	51288-51296	IN	denotes	Although
T31962	51326-51329	VBD	denotes	was
T31963	51297-51302	JJ	denotes	overt
T31964	51314-51325	NN	denotes	dysfunction
T31965	51303-51313	JJ	denotes	neurologic
T31966	51479-51485	VBD	denotes	showed
T31967	51330-51333	RB	denotes	not
T31968	51334-51342	JJ	denotes	apparent
T31969	51343-51345	IN	denotes	in
T31970	51346-51349	NN	denotes	PGC
T31971	51350-51352	NN	denotes	1α
T31972	51349-51350	HYPH	denotes	-
T31973	51356-51360	NNS	denotes	mice
T31974	51352-51353	SYM	denotes	−
T31975	51353-51354	HYPH	denotes	/
T31976	51354-51355	SYM	denotes	−
T31977	51361-51367	IN	denotes	during
T31978	51368-51371	DT	denotes	the
T31979	51380-51382	NN	denotes	mo
T31980	51372-51377	JJ	denotes	first
T31981	51378-51379	CD	denotes	6
T31982	51383-51385	IN	denotes	of
T31983	51386-51390	NN	denotes	life
T31984	51391-51392	-LRB-	denotes	(
T31985	51418-51423	VBN	denotes	found
T31986	51392-51394	DT	denotes	no
T31987	51401-51412	NNS	denotes	differences
T31988	51395-51400	NN	denotes	group
T31989	51413-51417	VBD	denotes	were
T31990	51424-51426	IN	denotes	on
T31991	51427-51431	CD	denotes	five
T31992	51435-51438	CD	denotes	six
T31993	51432-51434	IN	denotes	of
T31994	51452-51457	NNS	denotes	tests
T31995	51439-51451	NN	denotes	sensorimotor
T31996	51457-51458	-RRB-	denotes	)
T31997	51458-51460	,	denotes	,
T31998	51460-51463	DT	denotes	the
T31999	51474-51478	NNS	denotes	mice
T32000	51464-51467	NN	denotes	PGC
T32001	51468-51470	NN	denotes	1α
T32002	51467-51468	HYPH	denotes	-
T32003	51470-51471	SYM	denotes	−
T32004	51471-51472	HYPH	denotes	/
T32005	51472-51473	SYM	denotes	−
T32006	51486-51491	JJ	denotes	clear
T32007	51492-51500	NNS	denotes	deficits
T32008	51501-51503	IN	denotes	on
T32009	51504-51507	DT	denotes	the
T32010	51524-51528	NN	denotes	test
T32011	51508-51516	VBN	denotes	inverted
T32012	51517-51523	NN	denotes	screen
T32013	51528-51529	.	denotes	.
T32014	51529-51714	sentence	denotes	These deficits are likely due to impaired muscle strength in the PGC-1α−/− mice, but contributions by peripheral or central nervous system determinants (or both) could be contributory.
T32015	51530-51535	DT	denotes	These
T32016	51536-51544	NNS	denotes	deficits
T32017	51545-51548	VBP	denotes	are
T32018	51549-51555	RB	denotes	likely
T32019	51556-51559	IN	denotes	due
T32020	51560-51562	IN	denotes	to
T32021	51563-51571	VBN	denotes	impaired
T32022	51579-51587	NN	denotes	strength
T32023	51572-51578	NN	denotes	muscle
T32024	51588-51590	IN	denotes	in
T32025	51591-51594	DT	denotes	the
T32026	51605-51609	NNS	denotes	mice
T32027	51595-51598	NN	denotes	PGC
T32028	51599-51601	NN	denotes	1α
T32029	51598-51599	HYPH	denotes	-
T32030	51601-51602	SYM	denotes	−
T32031	51602-51603	HYPH	denotes	/
T32032	51603-51604	SYM	denotes	−
T32033	51609-51611	,	denotes	,
T32034	51611-51614	CC	denotes	but
T32035	51615-51628	NNS	denotes	contributions
T32036	51698-51700	VB	denotes	be
T32037	51629-51631	IN	denotes	by
T32038	51632-51642	JJ	denotes	peripheral
T32039	51662-51668	NN	denotes	system
T32040	51643-51645	CC	denotes	or
T32041	51646-51653	JJ	denotes	central
T32042	51654-51661	JJ	denotes	nervous
T32043	51669-51681	NNS	denotes	determinants
T32044	51682-51683	-LRB-	denotes	(
T32045	51683-51685	CC	denotes	or
T32046	51686-51690	DT	denotes	both
T32047	51690-51691	-RRB-	denotes	)
T32048	51692-51697	MD	denotes	could
T32049	51701-51713	JJ	denotes	contributory
T32050	51713-51714	.	denotes	.
T32051	51714-51869	sentence	denotes	Moreover, evidence of altered emotionality from the 1-h locomotor activity test also suggests the possibility of altered brain function in PGC-1α−/− mice.
T32052	51715-51723	RB	denotes	Moreover
T32053	51800-51808	VBZ	denotes	suggests
T32054	51723-51725	,	denotes	,
T32055	51725-51733	NN	denotes	evidence
T32056	51734-51736	IN	denotes	of
T32057	51737-51744	JJ	denotes	altered
T32058	51745-51757	NN	denotes	emotionality
T32059	51758-51762	IN	denotes	from
T32060	51763-51766	DT	denotes	the
T32061	51790-51794	NN	denotes	test
T32062	51767-51768	CD	denotes	1
T32063	51769-51770	NN	denotes	h
T32064	51768-51769	HYPH	denotes	-
T32065	51771-51780	NN	denotes	locomotor
T32066	51781-51789	NN	denotes	activity
T32067	51795-51799	RB	denotes	also
T32068	51809-51812	DT	denotes	the
T32069	51813-51824	NN	denotes	possibility
T32070	51825-51827	IN	denotes	of
T32071	51828-51835	JJ	denotes	altered
T32072	51842-51850	NN	denotes	function
T32073	51836-51841	NN	denotes	brain
T32074	51851-51853	IN	denotes	in
T32075	51854-51857	NN	denotes	PGC
T32076	51858-51860	NN	denotes	1α
T32077	51857-51858	HYPH	denotes	-
T32078	51864-51868	NNS	denotes	mice
T32079	51860-51861	SYM	denotes	−
T32080	51861-51862	HYPH	denotes	/
T32081	51862-51863	SYM	denotes	−
T32082	51868-51869	.	denotes	.
T32083	51869-52018	sentence	denotes	It will be of interest to determine whether the neurologic abnormalities contribute to the systemic metabolic abnormalities of the PGC-1α null mice.
T32084	51870-51872	PRP	denotes	It
T32085	51878-51880	VB	denotes	be
T32086	51873-51877	MD	denotes	will
T32087	51881-51883	IN	denotes	of
T32088	51884-51892	NN	denotes	interest
T32089	51893-51895	TO	denotes	to
T32090	51896-51905	VB	denotes	determine
T32091	51906-51913	IN	denotes	whether
T32092	51943-51953	VBP	denotes	contribute
T32093	51914-51917	DT	denotes	the
T32094	51929-51942	NNS	denotes	abnormalities
T32095	51918-51928	JJ	denotes	neurologic
T32096	51954-51956	IN	denotes	to
T32097	51957-51960	DT	denotes	the
T32098	51980-51993	NNS	denotes	abnormalities
T32099	51961-51969	JJ	denotes	systemic
T32100	51970-51979	JJ	denotes	metabolic
T32101	51994-51996	IN	denotes	of
T32102	51997-52000	DT	denotes	the
T32103	52013-52017	NNS	denotes	mice
T32104	52001-52004	NN	denotes	PGC
T32105	52005-52007	NN	denotes	1α
T32106	52004-52005	HYPH	denotes	-
T32107	52008-52012	JJ	denotes	null
T32108	52017-52018	.	denotes	.
T32109	52018-52151	sentence	denotes	During the preparation of this manuscript, Lin et al. reported an independent mouse line in which the PGC-1α gene was targeted [37].
T32110	52019-52025	IN	denotes	During
T32111	52073-52081	VBD	denotes	reported
T32112	52026-52029	DT	denotes	the
T32113	52030-52041	NN	denotes	preparation
T32114	52042-52044	IN	denotes	of
T32115	52045-52049	DT	denotes	this
T32116	52050-52060	NN	denotes	manuscript
T32117	52060-52062	,	denotes	,
T32118	52062-52065	NNP	denotes	Lin
T32119	52066-52068	FW	denotes	et
T32120	52069-52072	FW	denotes	al.
T32121	52082-52084	DT	denotes	an
T32122	52103-52107	NN	denotes	line
T32123	52085-52096	JJ	denotes	independent
T32124	52097-52102	NN	denotes	mouse
T32125	52108-52110	IN	denotes	in
T32126	52137-52145	VBN	denotes	targeted
T32127	52111-52116	WDT	denotes	which
T32128	52117-52120	DT	denotes	the
T32129	52128-52132	NN	denotes	gene
T32130	52121-52124	NN	denotes	PGC
T32131	52125-52127	NN	denotes	1α
T32132	52124-52125	HYPH	denotes	-
T32133	52133-52136	VBD	denotes	was
T32134	52146-52147	-LRB-	denotes	[
T32135	52147-52149	CD	denotes	37
T32136	52149-52150	-RRB-	denotes	]
T32137	52150-52151	.	denotes	.
T32138	52151-52300	sentence	denotes	Phenotypic comparison of the our PGC-1α-deficient line with that of Lin et al. reveals a number of similarities and several interesting differences.
T32139	52152-52162	JJ	denotes	Phenotypic
T32140	52163-52173	NN	denotes	comparison
T32141	52231-52238	VBZ	denotes	reveals
T32142	52174-52176	IN	denotes	of
T32143	52177-52180	DT	denotes	the
T32144	52181-52184	PRP$	denotes	our
T32145	52202-52206	NN	denotes	line
T32146	52185-52188	NN	denotes	PGC
T32147	52189-52191	NN	denotes	1α
T32148	52188-52189	HYPH	denotes	-
T32149	52192-52201	JJ	denotes	deficient
T32150	52191-52192	HYPH	denotes	-
T32151	52207-52211	IN	denotes	with
T32152	52212-52216	DT	denotes	that
T32153	52217-52219	IN	denotes	of
T32154	52220-52223	NNP	denotes	Lin
T32155	52224-52226	FW	denotes	et
T32156	52227-52230	FW	denotes	al.
T32157	52239-52240	DT	denotes	a
T32158	52241-52247	NN	denotes	number
T32159	52248-52250	IN	denotes	of
T32160	52251-52263	NNS	denotes	similarities
T32161	52264-52267	CC	denotes	and
T32162	52268-52275	JJ	denotes	several
T32163	52288-52299	NNS	denotes	differences
T32164	52276-52287	JJ	denotes	interesting
T32165	52299-52300	.	denotes	.
T32166	52300-52416	sentence	denotes	Both PGC-1α-deficient lines exhibit cold intolerance, reduced hepatocyte respiration rates, and neurologic lesions.
T32167	52301-52305	DT	denotes	Both
T32168	52323-52328	NNS	denotes	lines
T32169	52306-52309	NN	denotes	PGC
T32170	52310-52312	NN	denotes	1α
T32171	52309-52310	HYPH	denotes	-
T32172	52313-52322	JJ	denotes	deficient
T32173	52312-52313	HYPH	denotes	-
T32174	52329-52336	VBP	denotes	exhibit
T32175	52337-52341	NN	denotes	cold
T32176	52342-52353	NN	denotes	intolerance
T32177	52353-52355	,	denotes	,
T32178	52355-52362	VBN	denotes	reduced
T32179	52386-52391	NNS	denotes	rates
T32180	52363-52373	NN	denotes	hepatocyte
T32181	52374-52385	NN	denotes	respiration
T32182	52391-52393	,	denotes	,
T32183	52393-52396	CC	denotes	and
T32184	52397-52407	JJ	denotes	neurologic
T32185	52408-52415	NNS	denotes	lesions
T32186	52415-52416	.	denotes	.
T32187	52416-52474	sentence	denotes	However, a number of interesting differences are notable.
T32188	52417-52424	RB	denotes	However
T32189	52462-52465	VBP	denotes	are
T32190	52424-52426	,	denotes	,
T32191	52426-52427	DT	denotes	a
T32192	52428-52434	NN	denotes	number
T32193	52435-52437	IN	denotes	of
T32194	52438-52449	JJ	denotes	interesting
T32195	52450-52461	NNS	denotes	differences
T32196	52466-52473	JJ	denotes	notable
T32197	52473-52474	.	denotes	.
T32198	52474-52582	sentence	denotes	First, in contrast to Lin et al., the PGC-1α−/− mice described here do not exhibit any postnatal mortality.
T32199	52475-52480	RB	denotes	First
T32200	52550-52557	VB	denotes	exhibit
T32201	52480-52482	,	denotes	,
T32202	52482-52484	IN	denotes	in
T32203	52485-52493	NN	denotes	contrast
T32204	52494-52496	IN	denotes	to
T32205	52497-52500	NNP	denotes	Lin
T32206	52501-52503	FW	denotes	et
T32207	52504-52507	FW	denotes	al.
T32208	52507-52509	,	denotes	,
T32209	52509-52512	DT	denotes	the
T32210	52523-52527	NNS	denotes	mice
T32211	52513-52516	NN	denotes	PGC
T32212	52517-52519	NN	denotes	1α
T32213	52516-52517	HYPH	denotes	-
T32214	52519-52520	SYM	denotes	−
T32215	52520-52521	HYPH	denotes	/
T32216	52521-52522	SYM	denotes	−
T32217	52528-52537	VBN	denotes	described
T32218	52538-52542	RB	denotes	here
T32219	52543-52545	VBP	denotes	do
T32220	52546-52549	RB	denotes	not
T32221	52558-52561	DT	denotes	any
T32222	52572-52581	NN	denotes	mortality
T32223	52562-52571	JJ	denotes	postnatal
T32224	52581-52582	.	denotes	.
T32225	52582-52705	sentence	denotes	Second, we did not find evidence for a defect in gluconeogenesis based on fasting blood glucose levels (unpublished data).
T32226	52583-52589	RB	denotes	Second
T32227	52602-52606	VB	denotes	find
T32228	52589-52591	,	denotes	,
T32229	52591-52593	PRP	denotes	we
T32230	52594-52597	VBD	denotes	did
T32231	52598-52601	RB	denotes	not
T32232	52607-52615	NN	denotes	evidence
T32233	52616-52619	IN	denotes	for
T32234	52620-52621	DT	denotes	a
T32235	52622-52628	NN	denotes	defect
T32236	52629-52631	IN	denotes	in
T32237	52632-52647	NN	denotes	gluconeogenesis
T32238	52648-52653	VBN	denotes	based
T32239	52654-52656	IN	denotes	on
T32240	52657-52664	NN	denotes	fasting
T32241	52679-52685	NNS	denotes	levels
T32242	52665-52670	NN	denotes	blood
T32243	52671-52678	NN	denotes	glucose
T32244	52686-52687	-LRB-	denotes	(
T32245	52699-52703	NNS	denotes	data
T32246	52687-52698	JJ	denotes	unpublished
T32247	52703-52704	-RRB-	denotes	)
T32248	52704-52705	.	denotes	.
T32249	52705-52997	sentence	denotes	In addition, whereas Lin et al. found an abnormal expression profile for CCAAT-enhancer-binding protein β and δ and the gluconeogenic genes encoding phosphoenolpyruvate carboxykinase and glucose-6-phosphatase at baseline and with fasting in the PGC-1α−/− mice, we did not (unpublished data).
T32250	52706-52708	IN	denotes	In
T32251	52970-52973	VBD	denotes	did
T32252	52709-52717	NN	denotes	addition
T32253	52717-52719	,	denotes	,
T32254	52719-52726	IN	denotes	whereas
T32255	52738-52743	VBD	denotes	found
T32256	52727-52730	NNP	denotes	Lin
T32257	52731-52733	FW	denotes	et
T32258	52734-52737	FW	denotes	al.
T32259	52744-52746	DT	denotes	an
T32260	52767-52774	NN	denotes	profile
T32261	52747-52755	JJ	denotes	abnormal
T32262	52756-52766	NN	denotes	expression
T32263	52775-52778	IN	denotes	for
T32264	52779-52784	NN	denotes	CCAAT
T32265	52785-52793	NN	denotes	enhancer
T32266	52784-52785	HYPH	denotes	-
T32267	52794-52801	VBG	denotes	binding
T32268	52793-52794	HYPH	denotes	-
T32269	52810-52811	NN	denotes	β
T32270	52802-52809	NN	denotes	protein
T32271	52812-52815	CC	denotes	and
T32272	52816-52817	NN	denotes	δ
T32273	52818-52821	CC	denotes	and
T32274	52822-52825	DT	denotes	the
T32275	52840-52845	NNS	denotes	genes
T32276	52826-52839	JJ	denotes	gluconeogenic
T32277	52846-52854	VBG	denotes	encoding
T32278	52855-52874	NN	denotes	phosphoenolpyruvate
T32279	52875-52888	NN	denotes	carboxykinase
T32280	52889-52892	CC	denotes	and
T32281	52893-52900	NN	denotes	glucose
T32282	52903-52914	NN	denotes	phosphatase
T32283	52900-52901	HYPH	denotes	-
T32284	52901-52902	CD	denotes	6
T32285	52902-52903	HYPH	denotes	-
T32286	52915-52917	IN	denotes	at
T32287	52918-52926	NN	denotes	baseline
T32288	52927-52930	CC	denotes	and
T32289	52931-52935	IN	denotes	with
T32290	52936-52943	NN	denotes	fasting
T32291	52944-52946	IN	denotes	in
T32292	52947-52950	DT	denotes	the
T32293	52961-52965	NNS	denotes	mice
T32294	52951-52954	NN	denotes	PGC
T32295	52955-52957	NN	denotes	1α
T32296	52954-52955	HYPH	denotes	-
T32297	52957-52958	SYM	denotes	−
T32298	52958-52959	HYPH	denotes	/
T32299	52959-52960	SYM	denotes	−
T32300	52965-52967	,	denotes	,
T32301	52967-52969	PRP	denotes	we
T32302	52974-52977	RB	denotes	not
T32303	52978-52979	-LRB-	denotes	(
T32304	52991-52995	NNS	denotes	data
T32305	52979-52990	JJ	denotes	unpublished
T32306	52995-52996	-RRB-	denotes	)
T32307	52996-52997	.	denotes	.
T32308	52997-53215	sentence	denotes	Third, we found evidence for an age-related increase in body fat in PGC-1α−/− mice (females earlier than males), whereas Lin et al. identified a male-specific resistance to diet-induced obesity and insulin resistance.
T32309	52998-53003	RB	denotes	Third
T32310	53008-53013	VBD	denotes	found
T32311	53003-53005	,	denotes	,
T32312	53005-53007	PRP	denotes	we
T32313	53014-53022	NN	denotes	evidence
T32314	53023-53026	IN	denotes	for
T32315	53027-53029	DT	denotes	an
T32316	53042-53050	NN	denotes	increase
T32317	53030-53033	NN	denotes	age
T32318	53034-53041	VBN	denotes	related
T32319	53033-53034	HYPH	denotes	-
T32320	53051-53053	IN	denotes	in
T32321	53054-53058	NN	denotes	body
T32322	53059-53062	NN	denotes	fat
T32323	53063-53065	IN	denotes	in
T32324	53066-53069	NN	denotes	PGC
T32325	53070-53072	NN	denotes	1α
T32326	53069-53070	HYPH	denotes	-
T32327	53076-53080	NNS	denotes	mice
T32328	53072-53073	SYM	denotes	−
T32329	53073-53074	HYPH	denotes	/
T32330	53074-53075	SYM	denotes	−
T32331	53081-53082	-LRB-	denotes	(
T32332	53082-53089	NNS	denotes	females
T32333	53090-53097	RBR	denotes	earlier
T32334	53098-53102	IN	denotes	than
T32335	53103-53108	NNS	denotes	males
T32336	53108-53109	-RRB-	denotes	)
T32337	53109-53111	,	denotes	,
T32338	53111-53118	IN	denotes	whereas
T32339	53130-53140	VBD	denotes	identified
T32340	53119-53122	NNP	denotes	Lin
T32341	53123-53125	FW	denotes	et
T32342	53126-53129	FW	denotes	al.
T32343	53141-53142	DT	denotes	a
T32344	53157-53167	NN	denotes	resistance
T32345	53143-53147	NN	denotes	male
T32346	53148-53156	JJ	denotes	specific
T32347	53147-53148	HYPH	denotes	-
T32348	53168-53170	IN	denotes	to
T32349	53171-53175	NN	denotes	diet
T32350	53176-53183	VBN	denotes	induced
T32351	53175-53176	HYPH	denotes	-
T32352	53184-53191	NN	denotes	obesity
T32353	53192-53195	CC	denotes	and
T32354	53196-53203	NN	denotes	insulin
T32355	53204-53214	NN	denotes	resistance
T32356	53214-53215	.	denotes	.
T32357	53215-53331	sentence	denotes	We have also found that male PGC-1α-deficient mice are somewhat protected against diet-induced obesity (Figure S4).
T32358	53216-53218	PRP	denotes	We
T32359	53229-53234	VBN	denotes	found
T32360	53219-53223	VBP	denotes	have
T32361	53224-53228	RB	denotes	also
T32362	53235-53239	IN	denotes	that
T32363	53280-53289	VBN	denotes	protected
T32364	53240-53244	JJ	denotes	male
T32365	53262-53266	NNS	denotes	mice
T32366	53245-53248	NN	denotes	PGC
T32367	53249-53251	NN	denotes	1α
T32368	53248-53249	HYPH	denotes	-
T32369	53252-53261	JJ	denotes	deficient
T32370	53251-53252	HYPH	denotes	-
T32371	53267-53270	VBP	denotes	are
T32372	53271-53279	RB	denotes	somewhat
T32373	53290-53297	IN	denotes	against
T32374	53298-53302	NN	denotes	diet
T32375	53303-53310	VBN	denotes	induced
T32376	53302-53303	HYPH	denotes	-
T32377	53311-53318	NN	denotes	obesity
T32378	53319-53320	-LRB-	denotes	(
T32379	53327-53329	NN	denotes	S4
T32380	53320-53326	NN	denotes	Figure
T32381	53329-53330	-RRB-	denotes	)
T32382	53330-53331	.	denotes	.
T32383	53331-53484	sentence	denotes	However, we observed that the insulin-sensitive phenotype of the female PGC-1α−/− mice occurred in the context of normal weight gain with high-fat diet.
T32384	53332-53339	RB	denotes	However
T32385	53344-53352	VBD	denotes	observed
T32386	53339-53341	,	denotes	,
T32387	53341-53343	PRP	denotes	we
T32388	53353-53357	IN	denotes	that
T32389	53419-53427	VBD	denotes	occurred
T32390	53358-53361	DT	denotes	the
T32391	53380-53389	NN	denotes	phenotype
T32392	53362-53369	NN	denotes	insulin
T32393	53370-53379	JJ	denotes	sensitive
T32394	53369-53370	HYPH	denotes	-
T32395	53390-53392	IN	denotes	of
T32396	53393-53396	DT	denotes	the
T32397	53414-53418	NNS	denotes	mice
T32398	53397-53403	JJ	denotes	female
T32399	53404-53407	NN	denotes	PGC
T32400	53408-53410	NN	denotes	1α
T32401	53407-53408	HYPH	denotes	-
T32402	53410-53411	SYM	denotes	−
T32403	53411-53412	HYPH	denotes	/
T32404	53412-53413	SYM	denotes	−
T32405	53428-53430	IN	denotes	in
T32406	53431-53434	DT	denotes	the
T32407	53435-53442	NN	denotes	context
T32408	53443-53445	IN	denotes	of
T32409	53446-53452	JJ	denotes	normal
T32410	53460-53464	NN	denotes	gain
T32411	53453-53459	NN	denotes	weight
T32412	53465-53469	IN	denotes	with
T32413	53470-53474	JJ	denotes	high
T32414	53475-53478	NN	denotes	fat
T32415	53474-53475	HYPH	denotes	-
T32416	53479-53483	NN	denotes	diet
T32417	53483-53484	.	denotes	.
T32418	53484-53616	sentence	denotes	These latter results indicate that the insulin-sensitive phenotype of PGC-1α−/− mice cannot be fully explained by a lean phenotype.
T32419	53485-53490	DT	denotes	These
T32420	53498-53505	NNS	denotes	results
T32421	53491-53497	JJ	denotes	latter
T32422	53506-53514	VBP	denotes	indicate
T32423	53515-53519	IN	denotes	that
T32424	53586-53595	VBN	denotes	explained
T32425	53520-53523	DT	denotes	the
T32426	53542-53551	NN	denotes	phenotype
T32427	53524-53531	NN	denotes	insulin
T32428	53532-53541	JJ	denotes	sensitive
T32429	53531-53532	HYPH	denotes	-
T32430	53552-53554	IN	denotes	of
T32431	53555-53558	NN	denotes	PGC
T32432	53559-53561	NN	denotes	1α
T32433	53558-53559	HYPH	denotes	-
T32434	53565-53569	NNS	denotes	mice
T32435	53561-53562	SYM	denotes	−
T32436	53562-53563	HYPH	denotes	/
T32437	53563-53564	SYM	denotes	−
T32438	53570-53573	MD	denotes	can
T32439	53573-53576	RB	denotes	not
T32440	53577-53579	VB	denotes	be
T32441	53580-53585	RB	denotes	fully
T32442	53596-53598	IN	denotes	by
T32443	53599-53600	DT	denotes	a
T32444	53606-53615	NN	denotes	phenotype
T32445	53601-53605	JJ	denotes	lean
T32446	53615-53616	.	denotes	.
T32447	53616-53808	sentence	denotes	Of interest, mice lacking the nuclear receptor estrogen-related receptor α, a known target of PGC-1α, exhibit resistance to diet-induced obesity similar to that of male PGC-1α null mice [38].
T32448	53617-53619	IN	denotes	Of
T32449	53719-53726	VBP	denotes	exhibit
T32450	53620-53628	NN	denotes	interest
T32451	53628-53630	,	denotes	,
T32452	53630-53634	NNS	denotes	mice
T32453	53635-53642	VBG	denotes	lacking
T32454	53643-53646	DT	denotes	the
T32455	53655-53663	NN	denotes	receptor
T32456	53647-53654	JJ	denotes	nuclear
T32457	53664-53672	NN	denotes	estrogen
T32458	53673-53680	VBN	denotes	related
T32459	53672-53673	HYPH	denotes	-
T32460	53690-53691	NN	denotes	α
T32461	53681-53689	NN	denotes	receptor
T32462	53691-53693	,	denotes	,
T32463	53693-53694	DT	denotes	a
T32464	53701-53707	NN	denotes	target
T32465	53695-53700	JJ	denotes	known
T32466	53708-53710	IN	denotes	of
T32467	53711-53714	NN	denotes	PGC
T32468	53715-53717	NN	denotes	1α
T32469	53714-53715	HYPH	denotes	-
T32470	53717-53719	,	denotes	,
T32471	53727-53737	NN	denotes	resistance
T32472	53738-53740	IN	denotes	to
T32473	53741-53745	NN	denotes	diet
T32474	53746-53753	VBN	denotes	induced
T32475	53745-53746	HYPH	denotes	-
T32476	53754-53761	NN	denotes	obesity
T32477	53762-53769	JJ	denotes	similar
T32478	53770-53772	IN	denotes	to
T32479	53773-53777	DT	denotes	that
T32480	53778-53780	IN	denotes	of
T32481	53781-53785	JJ	denotes	male
T32482	53798-53802	NNS	denotes	mice
T32483	53786-53789	NN	denotes	PGC
T32484	53790-53792	NN	denotes	1α
T32485	53789-53790	HYPH	denotes	-
T32486	53793-53797	JJ	denotes	null
T32487	53803-53804	-LRB-	denotes	[
T32488	53804-53806	CD	denotes	38
T32489	53806-53807	-RRB-	denotes	]
T32490	53807-53808	.	denotes	.
T32491	53808-53953	sentence	denotes	Fourth, the PGC-1α−/− mice described here exhibit a dramatic fasting-induced hepatic steatotic phenotype, whereas the Lin et al. mouse does not.
T32492	53809-53815	RB	denotes	Fourth
T32493	53851-53858	VBP	denotes	exhibit
T32494	53815-53817	,	denotes	,
T32495	53817-53820	DT	denotes	the
T32496	53831-53835	NNS	denotes	mice
T32497	53821-53824	NN	denotes	PGC
T32498	53825-53827	NN	denotes	1α
T32499	53824-53825	HYPH	denotes	-
T32500	53827-53828	SYM	denotes	−
T32501	53828-53829	HYPH	denotes	/
T32502	53829-53830	SYM	denotes	−
T32503	53836-53845	VBN	denotes	described
T32504	53846-53850	RB	denotes	here
T32505	53859-53860	DT	denotes	a
T32506	53904-53913	NN	denotes	phenotype
T32507	53861-53869	JJ	denotes	dramatic
T32508	53870-53877	NN	denotes	fasting
T32509	53878-53885	VBN	denotes	induced
T32510	53877-53878	HYPH	denotes	-
T32511	53886-53893	JJ	denotes	hepatic
T32512	53894-53903	JJ	denotes	steatotic
T32513	53913-53915	,	denotes	,
T32514	53915-53922	IN	denotes	whereas
T32515	53944-53948	VBZ	denotes	does
T32516	53923-53926	DT	denotes	the
T32517	53938-53943	NN	denotes	mouse
T32518	53927-53930	NNP	denotes	Lin
T32519	53931-53933	FW	denotes	et
T32520	53934-53937	FW	denotes	al.
T32521	53949-53952	RB	denotes	not
T32522	53952-53953	.	denotes	.
T32523	53953-54116	sentence	denotes	Fifth, Lin et al. found a neurologic phenotype in males characterized by hyperactivity, whereas the PGC-1α−/− mice described here show reduced locomotor activity.
T32524	53954-53959	RB	denotes	Fifth
T32525	53972-53977	VBD	denotes	found
T32526	53959-53961	,	denotes	,
T32527	53961-53964	NNP	denotes	Lin
T32528	53965-53967	FW	denotes	et
T32529	53968-53971	FW	denotes	al.
T32530	53978-53979	DT	denotes	a
T32531	53991-54000	NN	denotes	phenotype
T32532	53980-53990	JJ	denotes	neurologic
T32533	54001-54003	IN	denotes	in
T32534	54004-54009	NNS	denotes	males
T32535	54010-54023	VBN	denotes	characterized
T32536	54024-54026	IN	denotes	by
T32537	54027-54040	NN	denotes	hyperactivity
T32538	54040-54042	,	denotes	,
T32539	54042-54049	IN	denotes	whereas
T32540	54084-54088	VBP	denotes	show
T32541	54050-54053	DT	denotes	the
T32542	54064-54068	NNS	denotes	mice
T32543	54054-54057	NN	denotes	PGC
T32544	54058-54060	NN	denotes	1α
T32545	54057-54058	HYPH	denotes	-
T32546	54060-54061	SYM	denotes	−
T32547	54061-54062	HYPH	denotes	/
T32548	54062-54063	SYM	denotes	−
T32549	54069-54078	VBN	denotes	described
T32550	54079-54083	RB	denotes	here
T32551	54089-54096	VBN	denotes	reduced
T32552	54107-54115	NN	denotes	activity
T32553	54097-54106	NN	denotes	locomotor
T32554	54115-54116	.	denotes	.
T32555	54116-54381	sentence	denotes	However, it should be noted that we did not study activity levels over an extended period of time in males as did Lin et al., so it is possible that our findings reflect an emotional disturbance that manifests only when the animals are placed in a new environment.
T32556	54117-54124	RB	denotes	However
T32557	54139-54144	VBN	denotes	noted
T32558	54124-54126	,	denotes	,
T32559	54126-54128	PRP	denotes	it
T32560	54129-54135	MD	denotes	should
T32561	54136-54138	VB	denotes	be
T32562	54249-54251	VBZ	denotes	is
T32563	54145-54149	IN	denotes	that
T32564	54161-54166	VB	denotes	study
T32565	54150-54152	PRP	denotes	we
T32566	54153-54156	VBD	denotes	did
T32567	54157-54160	RB	denotes	not
T32568	54167-54175	NN	denotes	activity
T32569	54176-54182	NNS	denotes	levels
T32570	54183-54187	IN	denotes	over
T32571	54188-54190	DT	denotes	an
T32572	54200-54206	NN	denotes	period
T32573	54191-54199	JJ	denotes	extended
T32574	54207-54209	IN	denotes	of
T32575	54210-54214	NN	denotes	time
T32576	54215-54217	IN	denotes	in
T32577	54218-54223	NNS	denotes	males
T32578	54224-54226	IN	denotes	as
T32579	54227-54230	VBD	denotes	did
T32580	54231-54234	NNP	denotes	Lin
T32581	54235-54237	FW	denotes	et
T32582	54238-54241	FW	denotes	al.
T32583	54241-54243	,	denotes	,
T32584	54243-54245	RB	denotes	so
T32585	54246-54248	PRP	denotes	it
T32586	54252-54260	JJ	denotes	possible
T32587	54261-54265	IN	denotes	that
T32588	54279-54286	VBP	denotes	reflect
T32589	54266-54269	PRP$	denotes	our
T32590	54270-54278	NNS	denotes	findings
T32591	54287-54289	DT	denotes	an
T32592	54300-54311	NN	denotes	disturbance
T32593	54290-54299	JJ	denotes	emotional
T32594	54312-54316	WDT	denotes	that
T32595	54317-54326	VBZ	denotes	manifests
T32596	54327-54331	RB	denotes	only
T32597	54353-54359	VBN	denotes	placed
T32598	54332-54336	WRB	denotes	when
T32599	54337-54340	DT	denotes	the
T32600	54341-54348	NNS	denotes	animals
T32601	54349-54352	VBP	denotes	are
T32602	54360-54362	IN	denotes	in
T32603	54363-54364	DT	denotes	a
T32604	54369-54380	NN	denotes	environment
T32605	54365-54368	JJ	denotes	new
T32606	54380-54381	.	denotes	.
T32607	54381-54580	sentence	denotes	Finally, we report significant skeletal muscle and cardiac functional abnormalities (although the report by Lin et al. did not address these phenotypes, so this may not represent a true difference).
T32608	54382-54389	RB	denotes	Finally
T32609	54394-54400	VBP	denotes	report
T32610	54389-54391	,	denotes	,
T32611	54391-54393	PRP	denotes	we
T32612	54401-54412	JJ	denotes	significant
T32613	54452-54465	NNS	denotes	abnormalities
T32614	54413-54421	JJ	denotes	skeletal
T32615	54422-54428	NN	denotes	muscle
T32616	54429-54432	CC	denotes	and
T32617	54433-54440	JJ	denotes	cardiac
T32618	54441-54451	JJ	denotes	functional
T32619	54466-54467	-LRB-	denotes	(
T32620	54467-54475	IN	denotes	although
T32621	54551-54560	VB	denotes	represent
T32622	54476-54479	DT	denotes	the
T32623	54480-54486	NN	denotes	report
T32624	54509-54516	VB	denotes	address
T32625	54487-54489	IN	denotes	by
T32626	54490-54493	NNP	denotes	Lin
T32627	54494-54496	FW	denotes	et
T32628	54497-54500	FW	denotes	al.
T32629	54501-54504	VBD	denotes	did
T32630	54505-54508	RB	denotes	not
T32631	54517-54522	DT	denotes	these
T32632	54523-54533	NNS	denotes	phenotypes
T32633	54533-54535	,	denotes	,
T32634	54535-54537	RB	denotes	so
T32635	54538-54542	DT	denotes	this
T32636	54543-54546	MD	denotes	may
T32637	54547-54550	RB	denotes	not
T32638	54561-54562	DT	denotes	a
T32639	54568-54578	NN	denotes	difference
T32640	54563-54567	JJ	denotes	true
T32641	54578-54579	-RRB-	denotes	)
T32642	54579-54580	.	denotes	.
T32643	54580-54684	sentence	denotes	The reasons for the interesting differences between the two PGC-1α-deficient mouse lines are not clear.
T32644	54581-54584	DT	denotes	The
T32645	54585-54592	NNS	denotes	reasons
T32646	54670-54673	VBP	denotes	are
T32647	54593-54596	IN	denotes	for
T32648	54597-54600	DT	denotes	the
T32649	54613-54624	NNS	denotes	differences
T32650	54601-54612	JJ	denotes	interesting
T32651	54625-54632	IN	denotes	between
T32652	54633-54636	DT	denotes	the
T32653	54664-54669	NNS	denotes	lines
T32654	54637-54640	CD	denotes	two
T32655	54641-54644	NN	denotes	PGC
T32656	54645-54647	NN	denotes	1α
T32657	54644-54645	HYPH	denotes	-
T32658	54648-54657	JJ	denotes	deficient
T32659	54647-54648	HYPH	denotes	-
T32660	54658-54663	NN	denotes	mouse
T32661	54674-54677	RB	denotes	not
T32662	54678-54683	JJ	denotes	clear
T32663	54683-54684	.	denotes	.
T32664	54684-54821	sentence	denotes	It is possible that distinct genetic backgrounds related to hybrid strains confer different degrees of secondary compensatory responses.
T32665	54685-54687	PRP	denotes	It
T32666	54688-54690	VBZ	denotes	is
T32667	54691-54699	JJ	denotes	possible
T32668	54700-54704	IN	denotes	that
T32669	54760-54766	VBP	denotes	confer
T32670	54705-54713	JJ	denotes	distinct
T32671	54722-54733	NNS	denotes	backgrounds
T32672	54714-54721	JJ	denotes	genetic
T32673	54734-54741	VBN	denotes	related
T32674	54742-54744	IN	denotes	to
T32675	54745-54751	NN	denotes	hybrid
T32676	54752-54759	NNS	denotes	strains
T32677	54767-54776	JJ	denotes	different
T32678	54777-54784	NNS	denotes	degrees
T32679	54785-54787	IN	denotes	of
T32680	54788-54797	JJ	denotes	secondary
T32681	54811-54820	NNS	denotes	responses
T32682	54798-54810	JJ	denotes	compensatory
T32683	54820-54821	.	denotes	.
T32684	54821-55071	sentence	denotes	In addition, the incompletely penetrant postnatal mortality noted in the PGC-1α−/− mice reported by Lin et al. could have resulted in a selection bias toward greater levels of compensatory responses in liver and other tissues in the surviving group.
T32685	54822-54824	IN	denotes	In
T32686	54944-54952	VBD	denotes	resulted
T32687	54825-54833	NN	denotes	addition
T32688	54833-54835	,	denotes	,
T32689	54835-54838	DT	denotes	the
T32690	54872-54881	NN	denotes	mortality
T32691	54839-54851	RB	denotes	incompletely
T32692	54852-54861	JJ	denotes	penetrant
T32693	54862-54871	JJ	denotes	postnatal
T32694	54882-54887	VBN	denotes	noted
T32695	54888-54890	IN	denotes	in
T32696	54891-54894	DT	denotes	the
T32697	54905-54909	NNS	denotes	mice
T32698	54895-54898	NN	denotes	PGC
T32699	54899-54901	NN	denotes	1α
T32700	54898-54899	HYPH	denotes	-
T32701	54901-54902	SYM	denotes	−
T32702	54902-54903	HYPH	denotes	/
T32703	54903-54904	SYM	denotes	−
T32704	54910-54918	VBN	denotes	reported
T32705	54919-54921	IN	denotes	by
T32706	54922-54925	NNP	denotes	Lin
T32707	54926-54928	FW	denotes	et
T32708	54929-54932	FW	denotes	al.
T32709	54933-54938	MD	denotes	could
T32710	54939-54943	VB	denotes	have
T32711	54953-54955	IN	denotes	in
T32712	54956-54957	DT	denotes	a
T32713	54968-54972	NN	denotes	bias
T32714	54958-54967	NN	denotes	selection
T32715	54973-54979	IN	denotes	toward
T32716	54980-54987	JJR	denotes	greater
T32717	54988-54994	NNS	denotes	levels
T32718	54995-54997	IN	denotes	of
T32719	54998-55010	JJ	denotes	compensatory
T32720	55011-55020	NNS	denotes	responses
T32721	55021-55023	IN	denotes	in
T32722	55024-55029	NN	denotes	liver
T32723	55030-55033	CC	denotes	and
T32724	55034-55039	JJ	denotes	other
T32725	55040-55047	NNS	denotes	tissues
T32726	55048-55050	IN	denotes	in
T32727	55051-55054	DT	denotes	the
T32728	55065-55070	NN	denotes	group
T32729	55055-55064	VBG	denotes	surviving
T32730	55070-55071	.	denotes	.
T32731	55071-55154	sentence	denotes	It is also possible that the method of gene targeting led to different phenotypes.
T32732	55072-55074	PRP	denotes	It
T32733	55075-55077	VBZ	denotes	is
T32734	55078-55082	RB	denotes	also
T32735	55083-55091	JJ	denotes	possible
T32736	55092-55096	IN	denotes	that
T32737	55126-55129	VBD	denotes	led
T32738	55097-55100	DT	denotes	the
T32739	55101-55107	NN	denotes	method
T32740	55108-55110	IN	denotes	of
T32741	55111-55115	NN	denotes	gene
T32742	55116-55125	NN	denotes	targeting
T32743	55130-55132	IN	denotes	to
T32744	55133-55142	JJ	denotes	different
T32745	55143-55153	NNS	denotes	phenotypes
T32746	55153-55154	.	denotes	.
T32747	55154-55252	sentence	denotes	Lin et al. generated PGC-1α−/− mice by Cre recombinase-mediated excision of exons 3–5 in oocytes.
T32748	55155-55158	NNP	denotes	Lin
T32749	55166-55175	VBN	denotes	generated
T32750	55159-55161	FW	denotes	et
T32751	55162-55165	FW	denotes	al.
T32752	55176-55179	NN	denotes	PGC
T32753	55180-55182	NN	denotes	1α
T32754	55179-55180	HYPH	denotes	-
T32755	55186-55190	NNS	denotes	mice
T32756	55182-55183	SYM	denotes	−
T32757	55183-55184	HYPH	denotes	/
T32758	55184-55185	SYM	denotes	−
T32759	55191-55193	IN	denotes	by
T32760	55194-55197	NN	denotes	Cre
T32761	55198-55209	NN	denotes	recombinase
T32762	55210-55218	VBN	denotes	mediated
T32763	55209-55210	HYPH	denotes	-
T32764	55219-55227	NN	denotes	excision
T32765	55228-55230	IN	denotes	of
T32766	55231-55236	NNS	denotes	exons
T32767	55237-55238	CD	denotes	3
T32768	55238-55239	SYM	denotes	–
T32769	55239-55240	CD	denotes	5
T32770	55241-55243	IN	denotes	in
T32771	55244-55251	NNS	denotes	oocytes
T32772	55251-55252	.	denotes	.
T32773	55252-55463	sentence	denotes	The PGC-1α−/− mice described here were generated by a targeting event that involved a 3′ homologous recombination leading to an insertion of the targeting vector including an extra exon 3 between exons 5 and 6.
T32774	55253-55256	DT	denotes	The
T32775	55267-55271	NNS	denotes	mice
T32776	55257-55260	NN	denotes	PGC
T32777	55261-55263	NN	denotes	1α
T32778	55260-55261	HYPH	denotes	-
T32779	55263-55264	SYM	denotes	−
T32780	55264-55265	HYPH	denotes	/
T32781	55265-55266	SYM	denotes	−
T32782	55292-55301	VBN	denotes	generated
T32783	55272-55281	VBN	denotes	described
T32784	55282-55286	RB	denotes	here
T32785	55287-55291	VBD	denotes	were
T32786	55302-55304	IN	denotes	by
T32787	55305-55306	DT	denotes	a
T32788	55317-55322	NN	denotes	event
T32789	55307-55316	NN	denotes	targeting
T32790	55323-55327	WDT	denotes	that
T32791	55328-55336	VBD	denotes	involved
T32792	55337-55338	DT	denotes	a
T32793	55353-55366	NN	denotes	recombination
T32794	55339-55340	CD	denotes	3
T32795	55340-55341	SYM	denotes	′
T32796	55342-55352	JJ	denotes	homologous
T32797	55367-55374	VBG	denotes	leading
T32798	55375-55377	IN	denotes	to
T32799	55378-55380	DT	denotes	an
T32800	55381-55390	NN	denotes	insertion
T32801	55391-55393	IN	denotes	of
T32802	55394-55397	DT	denotes	the
T32803	55408-55414	NN	denotes	vector
T32804	55398-55407	VBG	denotes	targeting
T32805	55415-55424	VBG	denotes	including
T32806	55425-55427	DT	denotes	an
T32807	55434-55438	NN	denotes	exon
T32808	55428-55433	JJ	denotes	extra
T32809	55439-55440	CD	denotes	3
T32810	55441-55448	IN	denotes	between
T32811	55449-55454	NNS	denotes	exons
T32812	55455-55456	CD	denotes	5
T32813	55457-55460	CC	denotes	and
T32814	55461-55462	CD	denotes	6
T32815	55462-55463	.	denotes	.
T32816	55463-55581	sentence	denotes	The exon 3 insertion, which was confirmed by RT-PCR, results in a mutant transcript that encodes a truncated protein.
T32817	55464-55467	DT	denotes	The
T32818	55475-55484	NN	denotes	insertion
T32819	55468-55472	NN	denotes	exon
T32820	55473-55474	CD	denotes	3
T32821	55517-55524	VBZ	denotes	results
T32822	55484-55486	,	denotes	,
T32823	55486-55491	WDT	denotes	which
T32824	55496-55505	VBN	denotes	confirmed
T32825	55492-55495	VBD	denotes	was
T32826	55506-55508	IN	denotes	by
T32827	55509-55511	NN	denotes	RT
T32828	55512-55515	NN	denotes	PCR
T32829	55511-55512	HYPH	denotes	-
T32830	55515-55517	,	denotes	,
T32831	55525-55527	IN	denotes	in
T32832	55528-55529	DT	denotes	a
T32833	55537-55547	NN	denotes	transcript
T32834	55530-55536	NN	denotes	mutant
T32835	55548-55552	WDT	denotes	that
T32836	55553-55560	VBZ	denotes	encodes
T32837	55561-55562	DT	denotes	a
T32838	55573-55580	NN	denotes	protein
T32839	55563-55572	VBN	denotes	truncated
T32840	55580-55581	.	denotes	.
T32841	55581-55712	sentence	denotes	We were unable to detect normal transcript containing an exon 5–6 border, indicating that the targeting was accurate and complete.
T32842	55582-55584	PRP	denotes	We
T32843	55585-55589	VBD	denotes	were
T32844	55590-55596	JJ	denotes	unable
T32845	55597-55599	TO	denotes	to
T32846	55600-55606	VB	denotes	detect
T32847	55607-55613	JJ	denotes	normal
T32848	55614-55624	NN	denotes	transcript
T32849	55625-55635	VBG	denotes	containing
T32850	55636-55638	DT	denotes	an
T32851	55648-55654	NN	denotes	border
T32852	55639-55643	NN	denotes	exon
T32853	55644-55645	CD	denotes	5
T32854	55645-55646	SYM	denotes	–
T32855	55646-55647	CD	denotes	6
T32856	55654-55656	,	denotes	,
T32857	55656-55666	VBG	denotes	indicating
T32858	55667-55671	IN	denotes	that
T32859	55686-55689	VBD	denotes	was
T32860	55672-55675	DT	denotes	the
T32861	55676-55685	NN	denotes	targeting
T32862	55690-55698	JJ	denotes	accurate
T32863	55699-55702	CC	denotes	and
T32864	55703-55711	JJ	denotes	complete
T32865	55711-55712	.	denotes	.
T32866	55712-55805	sentence	denotes	In addition, we could not detect full-length or smaller PGC-1α proteins by Western blotting.
T32867	55713-55715	IN	denotes	In
T32868	55739-55745	VB	denotes	detect
T32869	55716-55724	NN	denotes	addition
T32870	55724-55726	,	denotes	,
T32871	55726-55728	PRP	denotes	we
T32872	55729-55734	MD	denotes	could
T32873	55735-55738	RB	denotes	not
T32874	55746-55750	JJ	denotes	full
T32875	55751-55757	NN	denotes	length
T32876	55750-55751	HYPH	denotes	-
T32877	55776-55784	NN	denotes	proteins
T32878	55758-55760	CC	denotes	or
T32879	55761-55768	JJR	denotes	smaller
T32880	55769-55772	NN	denotes	PGC
T32881	55773-55775	NN	denotes	1α
T32882	55772-55773	HYPH	denotes	-
T32883	55785-55787	IN	denotes	by
T32884	55788-55795	NNP	denotes	Western
T32885	55796-55804	NN	denotes	blotting
T32886	55804-55805	.	denotes	.
T32887	55805-56112	sentence	denotes	However, we cannot exclude the possibility that the sensitivity of the immunoblotting was not high enough to pick up a small amount of mutant (truncated) PGC-1α protein that could have some activity, given that it would contain nuclear receptor-interacting domains and the amino-terminal activation domain.
T32888	55806-55813	RB	denotes	However
T32889	55825-55832	VB	denotes	exclude
T32890	55813-55815	,	denotes	,
T32891	55815-55817	PRP	denotes	we
T32892	55818-55821	MD	denotes	can
T32893	55821-55824	RB	denotes	not
T32894	55833-55836	DT	denotes	the
T32895	55837-55848	NN	denotes	possibility
T32896	55849-55853	IN	denotes	that
T32897	55892-55895	VBD	denotes	was
T32898	55854-55857	DT	denotes	the
T32899	55858-55869	NN	denotes	sensitivity
T32900	55870-55872	IN	denotes	of
T32901	55873-55876	DT	denotes	the
T32902	55877-55891	NN	denotes	immunoblotting
T32903	55896-55899	RB	denotes	not
T32904	55900-55904	JJ	denotes	high
T32905	55905-55911	RB	denotes	enough
T32906	55912-55914	TO	denotes	to
T32907	55915-55919	VB	denotes	pick
T32908	55920-55922	RP	denotes	up
T32909	55923-55924	DT	denotes	a
T32910	55931-55937	NN	denotes	amount
T32911	55925-55930	JJ	denotes	small
T32912	55938-55940	IN	denotes	of
T32913	55941-55947	NN	denotes	mutant
T32914	55967-55974	NN	denotes	protein
T32915	55948-55949	-LRB-	denotes	(
T32916	55949-55958	VBN	denotes	truncated
T32917	55958-55959	-RRB-	denotes	)
T32918	55960-55963	NN	denotes	PGC
T32919	55964-55966	NN	denotes	1α
T32920	55963-55964	HYPH	denotes	-
T32921	55975-55979	WDT	denotes	that
T32922	55986-55990	VB	denotes	have
T32923	55980-55985	MD	denotes	could
T32924	55991-55995	DT	denotes	some
T32925	55996-56004	NN	denotes	activity
T32926	56004-56006	,	denotes	,
T32927	56006-56011	VBN	denotes	given
T32928	56012-56016	IN	denotes	that
T32929	56026-56033	VB	denotes	contain
T32930	56017-56019	PRP	denotes	it
T32931	56020-56025	MD	denotes	would
T32932	56034-56041	JJ	denotes	nuclear
T32933	56042-56050	NN	denotes	receptor
T32934	56051-56062	VBG	denotes	interacting
T32935	56050-56051	HYPH	denotes	-
T32936	56063-56070	NNS	denotes	domains
T32937	56071-56074	CC	denotes	and
T32938	56075-56078	DT	denotes	the
T32939	56105-56111	NN	denotes	domain
T32940	56079-56084	NN	denotes	amino
T32941	56085-56093	JJ	denotes	terminal
T32942	56084-56085	HYPH	denotes	-
T32943	56094-56104	NN	denotes	activation
T32944	56111-56112	.	denotes	.
T32945	56112-56257	sentence	denotes	If small amounts of PGC-1α activity are present in the mice reported here, it could explain some of the observed differences between the models.
T32946	56113-56115	IN	denotes	If
T32947	56149-56152	VBP	denotes	are
T32948	56116-56121	JJ	denotes	small
T32949	56122-56129	NNS	denotes	amounts
T32950	56130-56132	IN	denotes	of
T32951	56133-56136	NN	denotes	PGC
T32952	56137-56139	NN	denotes	1α
T32953	56136-56137	HYPH	denotes	-
T32954	56140-56148	NN	denotes	activity
T32955	56197-56204	VB	denotes	explain
T32956	56153-56160	JJ	denotes	present
T32957	56161-56163	IN	denotes	in
T32958	56164-56167	DT	denotes	the
T32959	56168-56172	NNS	denotes	mice
T32960	56173-56181	VBN	denotes	reported
T32961	56182-56186	RB	denotes	here
T32962	56186-56188	,	denotes	,
T32963	56188-56190	PRP	denotes	it
T32964	56191-56196	MD	denotes	could
T32965	56205-56209	DT	denotes	some
T32966	56210-56212	IN	denotes	of
T32967	56213-56216	DT	denotes	the
T32968	56226-56237	NNS	denotes	differences
T32969	56217-56225	VBN	denotes	observed
T32970	56238-56245	IN	denotes	between
T32971	56246-56249	DT	denotes	the
T32972	56250-56256	NNS	denotes	models
T32973	56256-56257	.	denotes	.
T32974	56257-56391	sentence	denotes	However, the bulk of data presented here support the conclusion that the PGC-1α−/− mice described are completely deficient in PGC-1α.
T32975	56258-56265	RB	denotes	However
T32976	56299-56306	VBP	denotes	support
T32977	56265-56267	,	denotes	,
T32978	56267-56270	DT	denotes	the
T32979	56271-56275	NN	denotes	bulk
T32980	56276-56278	IN	denotes	of
T32981	56279-56283	NNS	denotes	data
T32982	56284-56293	VBN	denotes	presented
T32983	56294-56298	RB	denotes	here
T32984	56307-56310	DT	denotes	the
T32985	56311-56321	NN	denotes	conclusion
T32986	56322-56326	IN	denotes	that
T32987	56356-56359	VBP	denotes	are
T32988	56327-56330	DT	denotes	the
T32989	56341-56345	NNS	denotes	mice
T32990	56331-56334	NN	denotes	PGC
T32991	56335-56337	NN	denotes	1α
T32992	56334-56335	HYPH	denotes	-
T32993	56337-56338	SYM	denotes	−
T32994	56338-56339	HYPH	denotes	/
T32995	56339-56340	SYM	denotes	−
T32996	56346-56355	VBN	denotes	described
T32997	56360-56370	RB	denotes	completely
T32998	56371-56380	JJ	denotes	deficient
T32999	56381-56383	IN	denotes	in
T33000	56384-56387	NN	denotes	PGC
T33001	56388-56390	NN	denotes	1α
T33002	56387-56388	HYPH	denotes	-
T33003	56390-56391	.	denotes	.
T33004	56391-56487	sentence	denotes	Future direct comparison of the two mouse lines in pure background strains will be of interest.
T33005	56392-56398	JJ	denotes	Future
T33006	56406-56416	NN	denotes	comparison
T33007	56399-56405	JJ	denotes	direct
T33008	56472-56474	VB	denotes	be
T33009	56417-56419	IN	denotes	of
T33010	56420-56423	DT	denotes	the
T33011	56434-56439	NNS	denotes	lines
T33012	56424-56427	CD	denotes	two
T33013	56428-56433	NN	denotes	mouse
T33014	56440-56442	IN	denotes	in
T33015	56443-56447	JJ	denotes	pure
T33016	56459-56466	NNS	denotes	strains
T33017	56448-56458	NN	denotes	background
T33018	56467-56471	MD	denotes	will
T33019	56475-56477	IN	denotes	of
T33020	56478-56486	NN	denotes	interest
T33021	56486-56487	.	denotes	.
T33022	56487-56630	sentence	denotes	In summary, this body of work provides evidence that PGC-lα is critical for the adaptive responses necessary to meet postnatal energy demands.
T33023	56488-56490	IN	denotes	In
T33024	56518-56526	VBZ	denotes	provides
T33025	56491-56498	NN	denotes	summary
T33026	56498-56500	,	denotes	,
T33027	56500-56504	DT	denotes	this
T33028	56505-56509	NN	denotes	body
T33029	56510-56512	IN	denotes	of
T33030	56513-56517	NN	denotes	work
T33031	56527-56535	NN	denotes	evidence
T33032	56536-56540	IN	denotes	that
T33033	56548-56550	VBZ	denotes	is
T33034	56541-56544	NN	denotes	PGC
T33035	56545-56547	NN	denotes	lα
T33036	56544-56545	HYPH	denotes	-
T33037	56551-56559	JJ	denotes	critical
T33038	56560-56563	IN	denotes	for
T33039	56564-56567	DT	denotes	the
T33040	56577-56586	NNS	denotes	responses
T33041	56568-56576	JJ	denotes	adaptive
T33042	56587-56596	JJ	denotes	necessary
T33043	56597-56599	TO	denotes	to
T33044	56600-56604	VB	denotes	meet
T33045	56605-56614	JJ	denotes	postnatal
T33046	56622-56629	NNS	denotes	demands
T33047	56615-56621	NN	denotes	energy
T33048	56629-56630	.	denotes	.
T33049	56630-56898	sentence	denotes	Our results also suggest a broader role for inducible transcriptional coactivators such as PGC-1α in transducing cellular signals triggered by physiologic and developmental cues to the transcriptional control of energy metabolism and other dynamic cellular processes.
T33050	56631-56634	PRP$	denotes	Our
T33051	56635-56642	NNS	denotes	results
T33052	56648-56655	VBP	denotes	suggest
T33053	56643-56647	RB	denotes	also
T33054	56656-56657	DT	denotes	a
T33055	56666-56670	NN	denotes	role
T33056	56658-56665	JJR	denotes	broader
T33057	56671-56674	IN	denotes	for
T33058	56675-56684	JJ	denotes	inducible
T33059	56701-56713	NNS	denotes	coactivators
T33060	56685-56700	JJ	denotes	transcriptional
T33061	56714-56718	JJ	denotes	such
T33062	56719-56721	IN	denotes	as
T33063	56722-56725	NN	denotes	PGC
T33064	56726-56728	NN	denotes	1α
T33065	56725-56726	HYPH	denotes	-
T33066	56729-56731	IN	denotes	in
T33067	56732-56743	VBG	denotes	transducing
T33068	56744-56752	JJ	denotes	cellular
T33069	56753-56760	NNS	denotes	signals
T33070	56761-56770	VBN	denotes	triggered
T33071	56771-56773	IN	denotes	by
T33072	56774-56785	JJ	denotes	physiologic
T33073	56804-56808	NNS	denotes	cues
T33074	56786-56789	CC	denotes	and
T33075	56790-56803	JJ	denotes	developmental
T33076	56809-56811	IN	denotes	to
T33077	56812-56815	DT	denotes	the
T33078	56832-56839	NN	denotes	control
T33079	56816-56831	JJ	denotes	transcriptional
T33080	56840-56842	IN	denotes	of
T33081	56843-56849	NN	denotes	energy
T33082	56850-56860	NN	denotes	metabolism
T33083	56861-56864	CC	denotes	and
T33084	56865-56870	JJ	denotes	other
T33085	56888-56897	NNS	denotes	processes
T33086	56871-56878	JJ	denotes	dynamic
T33087	56879-56887	JJ	denotes	cellular
T33088	56897-56898	.	denotes	.
T33089	56898-57098	sentence	denotes	In this regard, the inducible coactivator PGC-1α serves as a transcriptional “booster” to augment the capacity of downstream metabolic pathways critical for metabolic maturation and postnatal growth.
T33090	56899-56901	IN	denotes	In
T33091	56948-56954	VBZ	denotes	serves
T33092	56902-56906	DT	denotes	this
T33093	56907-56913	NN	denotes	regard
T33094	56913-56915	,	denotes	,
T33095	56915-56918	DT	denotes	the
T33096	56929-56940	NN	denotes	coactivator
T33097	56919-56928	JJ	denotes	inducible
T33098	56941-56944	NN	denotes	PGC
T33099	56945-56947	NN	denotes	1α
T33100	56944-56945	HYPH	denotes	-
T33101	56955-56957	IN	denotes	as
T33102	56958-56959	DT	denotes	a
T33103	56977-56984	NN	denotes	booster
T33104	56960-56975	JJ	denotes	transcriptional
T33105	56976-56977	``	denotes	“
T33106	56984-56985	''	denotes	”
T33107	56986-56988	TO	denotes	to
T33108	56989-56996	VB	denotes	augment
T33109	56997-57000	DT	denotes	the
T33110	57001-57009	NN	denotes	capacity
T33111	57010-57012	IN	denotes	of
T33112	57013-57023	JJ	denotes	downstream
T33113	57034-57042	NNS	denotes	pathways
T33114	57024-57033	JJ	denotes	metabolic
T33115	57043-57051	JJ	denotes	critical
T33116	57052-57055	IN	denotes	for
T33117	57056-57065	JJ	denotes	metabolic
T33118	57066-57076	NN	denotes	maturation
T33119	57077-57080	CC	denotes	and
T33120	57081-57090	JJ	denotes	postnatal
T33121	57091-57097	NN	denotes	growth
T33122	57097-57098	.	denotes	.
T33123	57098-57303	sentence	denotes	Indeed, although PGC-1α null mice survive in the protected environment of the laboratory, our results indicate that in the rigors of a typical external environment, PGC-1α would be necessary for survival.
T33124	57099-57105	RB	denotes	Indeed
T33125	57201-57209	VBP	denotes	indicate
T33126	57105-57107	,	denotes	,
T33127	57107-57115	IN	denotes	although
T33128	57133-57140	VBP	denotes	survive
T33129	57116-57119	NN	denotes	PGC
T33130	57120-57122	NN	denotes	1α
T33154	57262-57264	,	denotes	,
T33155	57264-57267	NN	denotes	PGC
T33156	57268-57270	NN	denotes	1α
T33157	57267-57268	HYPH	denotes	-
T33158	57271-57276	MD	denotes	would
T33159	57280-57289	JJ	denotes	necessary
T33160	57290-57293	IN	denotes	for
T33161	57294-57302	NN	denotes	survival
T33162	57302-57303	.	denotes	.
T33163	57303-57550	sentence	denotes	Lastly, we propose that the PGC-1α−/− mice should serve as a useful murine model to investigate the role of altered energy metabolism in obesity, diabetes, hepatic steatosis, and diseases of the heart, skeletal muscle, and central nervous system.
T33164	57304-57310	RB	denotes	Lastly
T33165	57315-57322	VBP	denotes	propose
T33166	57310-57312	,	denotes	,
T33167	57312-57314	PRP	denotes	we
T33168	57323-57327	IN	denotes	that
T33169	57354-57359	VB	denotes	serve
T33170	57328-57331	DT	denotes	the
T33171	57342-57346	NNS	denotes	mice
T33172	57332-57335	NN	denotes	PGC
T33173	57336-57338	NN	denotes	1α
T33174	57335-57336	HYPH	denotes	-
T33175	57338-57339	SYM	denotes	−
T33176	57339-57340	HYPH	denotes	/
T33177	57340-57341	SYM	denotes	−
T33178	57347-57353	MD	denotes	should
T33179	57360-57362	IN	denotes	as
T33180	57363-57364	DT	denotes	a
T33181	57379-57384	NN	denotes	model
T33182	57365-57371	JJ	denotes	useful
T33183	57372-57378	JJ	denotes	murine
T33184	57385-57387	TO	denotes	to
T33185	57388-57399	VB	denotes	investigate
T33186	57400-57403	DT	denotes	the
T33187	57404-57408	NN	denotes	role
T33188	57409-57411	IN	denotes	of
T33189	57412-57419	JJ	denotes	altered
T33190	57427-57437	NN	denotes	metabolism
T33191	57420-57426	NN	denotes	energy
T33192	57438-57440	IN	denotes	in
T33193	57441-57448	NN	denotes	obesity
T33194	57448-57450	,	denotes	,
T33195	57450-57458	NN	denotes	diabetes
T33196	57458-57460	,	denotes	,
T33197	57460-57467	JJ	denotes	hepatic
T33198	57468-57477	NN	denotes	steatosis
T33199	57477-57479	,	denotes	,
T33200	57479-57482	CC	denotes	and
T33201	57483-57491	NNS	denotes	diseases
T33202	57492-57494	IN	denotes	of
T33203	57495-57498	DT	denotes	the
T33204	57499-57504	NN	denotes	heart
T33205	57504-57506	,	denotes	,
T33206	57506-57514	JJ	denotes	skeletal
T33207	57515-57521	NN	denotes	muscle
T33208	57521-57523	,	denotes	,
T33209	57523-57526	CC	denotes	and
T33210	57527-57534	JJ	denotes	central
T33211	57543-57549	NN	denotes	system
T33212	57535-57542	JJ	denotes	nervous
T33213	57549-57550	.	denotes	.
T34068	57575-57584	VBG	denotes	Targeting
T34069	57585-57588	DT	denotes	the
T34070	57596-57600	NN	denotes	gene
T34071	57589-57592	NN	denotes	PGC
T34072	57593-57595	NN	denotes	1α
T34073	57592-57593	HYPH	denotes	-
T34074	57601-57603	IN	denotes	in
T34075	57604-57608	NNS	denotes	mice
T34076	57608-57777	sentence	denotes	A BAC genomic clone containing the murine PGC-1α gene, isolated from an Sv129 genomic library, was obtained from Incyte Genomics (Palo Alto, California, United States).
T34077	57609-57610	DT	denotes	A
T34078	57623-57628	NN	denotes	clone
T34079	57611-57614	NN	denotes	BAC
T34080	57615-57622	JJ	denotes	genomic
T34081	57708-57716	VBN	denotes	obtained
T34082	57629-57639	VBG	denotes	containing
T34083	57640-57643	DT	denotes	the
T34084	57658-57662	NN	denotes	gene
T34085	57644-57650	JJ	denotes	murine
T34086	57651-57654	NN	denotes	PGC
T34087	57655-57657	NN	denotes	1α
T34088	57654-57655	HYPH	denotes	-
T34089	57662-57664	,	denotes	,
T34090	57664-57672	VBN	denotes	isolated
T34091	57673-57677	IN	denotes	from
T34092	57678-57680	DT	denotes	an
T34093	57695-57702	NN	denotes	library
T34094	57681-57686	NN	denotes	Sv129
T34095	57687-57694	JJ	denotes	genomic
T34096	57702-57704	,	denotes	,
T34097	57704-57707	VBD	denotes	was
T34098	57717-57721	IN	denotes	from
T34099	57722-57728	NNP	denotes	Incyte
T34100	57729-57737	NNP	denotes	Genomics
T34101	57738-57739	-LRB-	denotes	(
T34102	57744-57748	NNP	denotes	Alto
T34103	57739-57743	NNP	denotes	Palo
T34104	57748-57750	,	denotes	,
T34105	57750-57760	NNP	denotes	California
T34106	57760-57762	,	denotes	,
T34107	57762-57768	NNP	denotes	United
T34108	57769-57775	NNP	denotes	States
T34109	57775-57776	-RRB-	denotes	)
T34110	57776-57777	.	denotes	.
T34111	57777-57845	sentence	denotes	A 3-kb region spanning exon 3 was amplified from the genomic clone.
T34112	57778-57779	DT	denotes	A
T34113	57785-57791	NN	denotes	region
T34114	57780-57781	CD	denotes	3
T34115	57782-57784	NN	denotes	kb
T34116	57781-57782	HYPH	denotes	-
T34117	57812-57821	VBN	denotes	amplified
T34118	57792-57800	VBG	denotes	spanning
T34119	57801-57805	NN	denotes	exon
T34120	57806-57807	CD	denotes	3
T34121	57808-57811	VBD	denotes	was
T34122	57822-57826	IN	denotes	from
T34123	57827-57830	DT	denotes	the
T34124	57839-57844	NN	denotes	clone
T34125	57831-57838	JJ	denotes	genomic
T34126	57844-57845	.	denotes	.
T34127	57845-58029	sentence	denotes	A 5′ primer was designed to amplify a fragment with the 5′ end beginning 732 bp upstream of exon 3 just upstream of an endogenous Kpn1 restriction site (5′- AGTTTCCTTAGCAACTTCATA-3′).
T34128	57846-57847	DT	denotes	A
T34129	57851-57857	NN	denotes	primer
T34130	57848-57849	CD	denotes	5
T34131	57849-57850	SYM	denotes	′
T34132	57862-57870	VBN	denotes	designed
T34133	57858-57861	VBD	denotes	was
T34134	57871-57873	TO	denotes	to
T34135	57874-57881	VB	denotes	amplify
T34136	57882-57883	DT	denotes	a
T34137	57884-57892	NN	denotes	fragment
T34138	57893-57897	IN	denotes	with
T34139	57898-57901	DT	denotes	the
T34140	57905-57908	NN	denotes	end
T34141	57902-57903	CD	denotes	5
T34142	57903-57904	SYM	denotes	′
T34143	57909-57918	VBG	denotes	beginning
T34144	57919-57922	CD	denotes	732
T34145	57923-57925	NN	denotes	bp
T34146	57926-57934	RB	denotes	upstream
T34147	57935-57937	IN	denotes	of
T34148	57938-57942	NN	denotes	exon
T34149	57943-57944	CD	denotes	3
T34150	57945-57949	RB	denotes	just
T34151	57950-57958	RB	denotes	upstream
T34152	57959-57961	IN	denotes	of
T34153	57962-57964	DT	denotes	an
T34154	57993-57997	NN	denotes	site
T34155	57965-57975	JJ	denotes	endogenous
T34156	57976-57980	NN	denotes	Kpn1
T34157	57981-57992	NN	denotes	restriction
T34158	57998-57999	-LRB-	denotes	(
T34159	58003-58024	NN	denotes	AGTTTCCTTAGCAACTTCATA
T34160	57999-58000	CD	denotes	5
T34161	58000-58001	SYM	denotes	′
T34162	58001-58002	HYPH	denotes	-
T34163	58024-58025	HYPH	denotes	-
T34164	58025-58026	CD	denotes	3
T34165	58026-58027	SYM	denotes	′
T34166	58027-58028	-RRB-	denotes	)
T34167	58028-58029	.	denotes	.
T34168	58029-58152	sentence	denotes	The 3′ primer contained a BamH1 site engineered by mutating the bases shown in lowercase (5′- AAGGATTTTAgGATcc CAGTAC-3′).
T34169	58030-58033	DT	denotes	The
T34170	58037-58043	NN	denotes	primer
T34171	58034-58035	CD	denotes	3
T34172	58035-58036	SYM	denotes	′
T34173	58044-58053	VBD	denotes	contained
T34174	58054-58055	DT	denotes	a
T34175	58062-58066	NN	denotes	site
T34176	58056-58061	NN	denotes	BamH1
T34177	58067-58077	VBN	denotes	engineered
T34178	58078-58080	IN	denotes	by
T34179	58081-58089	VBG	denotes	mutating
T34180	58090-58093	DT	denotes	the
T34181	58094-58099	NNS	denotes	bases
T34182	58100-58105	VBN	denotes	shown
T34183	58106-58108	IN	denotes	in
T34184	58109-58118	NN	denotes	lowercase
T34185	58119-58120	-LRB-	denotes	(
T34186	58124-58147	NN	denotes	AAGGATTTTAgGATcc CAGTAC
T34187	58120-58121	CD	denotes	5
T34188	58121-58122	SYM	denotes	′
T34189	58122-58123	HYPH	denotes	-
T34190	58147-58148	HYPH	denotes	-
T34191	58148-58149	CD	denotes	3
T34192	58149-58150	SYM	denotes	′
T34193	58150-58151	-RRB-	denotes	)
T34194	58151-58152	.	denotes	.
T34195	58152-58206	sentence	denotes	A second fragment downstream of exon 5 was amplified.
T34196	58153-58154	DT	denotes	A
T34197	58162-58170	NN	denotes	fragment
T34198	58155-58161	JJ	denotes	second
T34199	58196-58205	VBN	denotes	amplified
T34200	58171-58181	RB	denotes	downstream
T34201	58182-58184	IN	denotes	of
T34202	58185-58189	NN	denotes	exon
T34203	58190-58191	CD	denotes	5
T34204	58192-58195	VBD	denotes	was
T34205	58205-58206	.	denotes	.
T34206	58206-58375	sentence	denotes	In this latter amplicon, Not1 and Xho1 sites were engineered into the 5′ and 3′ primers, respectively (5′- TGGAGTgc GGCCGCTGGGA-3′ and 5′- AAAGAGTCTCgAg AATAGTTTCT-3′).
T34207	58207-58209	IN	denotes	In
T34208	58257-58267	VBN	denotes	engineered
T34209	58210-58214	DT	denotes	this
T34210	58222-58230	NN	denotes	amplicon
T34211	58215-58221	JJ	denotes	latter
T34212	58230-58232	,	denotes	,
T34213	58232-58236	NN	denotes	Not1
T34214	58246-58251	NNS	denotes	sites
T34215	58237-58240	CC	denotes	and
T34216	58241-58245	NN	denotes	Xho1
T34217	58252-58256	VBD	denotes	were
T34218	58268-58272	IN	denotes	into
T34219	58273-58276	DT	denotes	the
T34220	58277-58278	CD	denotes	5
T34221	58287-58294	NNS	denotes	primers
T34222	58278-58279	SYM	denotes	′
T34223	58280-58283	CC	denotes	and
T34224	58284-58285	CD	denotes	3
T34225	58285-58286	SYM	denotes	′
T34226	58294-58296	,	denotes	,
T34227	58296-58308	RB	denotes	respectively
T34228	58309-58310	-LRB-	denotes	(
T34229	58314-58334	NN	denotes	TGGAGTgc GGCCGCTGGGA
T34230	58310-58311	CD	denotes	5
T34231	58311-58312	SYM	denotes	′
T34232	58312-58313	HYPH	denotes	-
T34233	58334-58335	HYPH	denotes	-
T34234	58335-58336	CD	denotes	3
T34235	58336-58337	SYM	denotes	′
T34236	58338-58341	CC	denotes	and
T34237	58342-58343	CD	denotes	5
T34238	58346-58370	NN	denotes	AAAGAGTCTCgAg AATAGTTTCT
T34239	58343-58344	SYM	denotes	′
T34240	58344-58345	HYPH	denotes	-
T34241	58370-58371	HYPH	denotes	-
T34242	58371-58372	CD	denotes	3
T34243	58372-58373	SYM	denotes	′
T34244	58373-58374	-RRB-	denotes	)
T34245	58374-58375	.	denotes	.
T34246	58375-58443	sentence	denotes	The fragments were cloned into p1339-PGK-Neomycin targeting vector.
T34247	58376-58379	DT	denotes	The
T34248	58380-58389	NNS	denotes	fragments
T34249	58395-58401	VBN	denotes	cloned
T34250	58390-58394	VBD	denotes	were
T34251	58402-58406	IN	denotes	into
T34252	58407-58412	NN	denotes	p1339
T34253	58417-58425	NN	denotes	Neomycin
T34254	58412-58413	HYPH	denotes	-
T34255	58413-58416	NN	denotes	PGK
T34256	58416-58417	HYPH	denotes	-
T34257	58436-58442	NN	denotes	vector
T34258	58426-58435	NN	denotes	targeting
T34259	58442-58443	.	denotes	.
T34260	58443-58557	sentence	denotes	The construct was linearized with Xho1 and electroporated into RW4 ES cells (Sv129 derived) using G418 selection.
T34261	58444-58447	DT	denotes	The
T34262	58448-58457	NN	denotes	construct
T34263	58462-58472	VBN	denotes	linearized
T34264	58458-58461	VBD	denotes	was
T34265	58473-58477	IN	denotes	with
T34266	58478-58482	NN	denotes	Xho1
T34267	58483-58486	CC	denotes	and
T34268	58487-58501	VBN	denotes	electroporated
T34269	58502-58506	IN	denotes	into
T34270	58507-58510	NN	denotes	RW4
T34271	58514-58519	NNS	denotes	cells
T34272	58511-58513	NN	denotes	ES
T34273	58520-58521	-LRB-	denotes	(
T34274	58521-58526	NN	denotes	Sv129
T34275	58527-58534	VBN	denotes	derived
T34276	58534-58535	-RRB-	denotes	)
T34277	58536-58541	VBG	denotes	using
T34278	58542-58546	NN	denotes	G418
T34279	58547-58556	NN	denotes	selection
T34280	58556-58557	.	denotes	.
T34281	58557-58696	sentence	denotes	The electroporation was performed by the Siteman Cancer Center ES Cell Core at Washington University (St. Louis, Missouri, United States).
T34282	58558-58561	DT	denotes	The
T34283	58562-58577	NN	denotes	electroporation
T34284	58582-58591	VBN	denotes	performed
T34285	58578-58581	VBD	denotes	was
T34286	58592-58594	IN	denotes	by
T34287	58595-58598	DT	denotes	the
T34288	58629-58633	NNP	denotes	Core
T34289	58599-58606	NNP	denotes	Siteman
T34290	58614-58620	NNP	denotes	Center
T34291	58607-58613	NNP	denotes	Cancer
T34292	58621-58623	NNP	denotes	ES
T34293	58624-58628	NNP	denotes	Cell
T34294	58634-58636	IN	denotes	at
T34295	58637-58647	NNP	denotes	Washington
T34296	58648-58658	NNP	denotes	University
T34297	58659-58660	-LRB-	denotes	(
T34298	58664-58669	NNP	denotes	Louis
T34299	58660-58663	NNP	denotes	St.
T34300	58669-58671	,	denotes	,
T34301	58671-58679	NNP	denotes	Missouri
T34302	58679-58681	,	denotes	,
T34303	58681-58687	NNP	denotes	United
T34304	58688-58694	NNP	denotes	States
T34305	58694-58695	-RRB-	denotes	)
T34306	58695-58696	.	denotes	.
T34307	58696-58783	sentence	denotes	The clones were screened by Southern blot using an Xba1 digest (see Figure 1A and 1B).
T34308	58697-58700	DT	denotes	The
T34309	58701-58707	NNS	denotes	clones
T34310	58713-58721	VBN	denotes	screened
T34311	58708-58712	VBD	denotes	were
T34312	58722-58724	IN	denotes	by
T34313	58725-58733	NNP	denotes	Southern
T34314	58734-58738	NN	denotes	blot
T34315	58739-58744	VBG	denotes	using
T34316	58745-58747	DT	denotes	an
T34317	58753-58759	NN	denotes	digest
T34318	58748-58752	NN	denotes	Xba1
T34319	58760-58761	-LRB-	denotes	(
T34320	58761-58764	VB	denotes	see
T34321	58765-58771	NN	denotes	Figure
T34322	58772-58774	NN	denotes	1A
T34323	58775-58778	CC	denotes	and
T34324	58779-58781	NN	denotes	1B
T34325	58781-58782	-RRB-	denotes	)
T34326	58782-58783	.	denotes	.
T34327	58783-58919	sentence	denotes	One clone out of approximately 400 screened was positive for the homologous recombination on the 3′ end and an insertion on the 5′ end.
T34328	58784-58787	CD	denotes	One
T34329	58788-58793	NN	denotes	clone
T34330	58828-58831	VBD	denotes	was
T34331	58794-58797	IN	denotes	out
T34332	58798-58800	IN	denotes	of
T34333	58801-58814	RB	denotes	approximately
T34334	58815-58818	CD	denotes	400
T34335	58819-58827	VBN	denotes	screened
T34336	58832-58840	JJ	denotes	positive
T34337	58841-58844	IN	denotes	for
T34338	58845-58848	DT	denotes	the
T34339	58860-58873	NN	denotes	recombination
T34340	58849-58859	JJ	denotes	homologous
T34341	58874-58876	IN	denotes	on
T34342	58877-58880	DT	denotes	the
T34343	58884-58887	NN	denotes	end
T34344	58881-58882	CD	denotes	3
T34345	58882-58883	SYM	denotes	′
T34346	58888-58891	CC	denotes	and
T34347	58892-58894	DT	denotes	an
T34348	58895-58904	NN	denotes	insertion
T34349	58905-58907	IN	denotes	on
T34350	58908-58911	DT	denotes	the
T34351	58915-58918	NN	denotes	end
T34352	58912-58913	CD	denotes	5
T34353	58913-58914	SYM	denotes	′
T34354	58918-58919	.	denotes	.
T34355	58919-58971	sentence	denotes	This clone was injected into a C57BL6/J blastocyst.
T34356	58920-58924	DT	denotes	This
T34357	58925-58930	NN	denotes	clone
T34358	58935-58943	VBN	denotes	injected
T34359	58931-58934	VBD	denotes	was
T34360	58944-58948	IN	denotes	into
T34361	58949-58950	DT	denotes	a
T34362	58960-58970	NN	denotes	blastocyst
T34363	58951-58957	NN	denotes	C57BL6
T34364	58958-58959	NN	denotes	J
T34365	58957-58958	HYPH	denotes	/
T34366	58970-58971	.	denotes	.
T34367	58971-59098	sentence	denotes	Chimeras were mated to C57BL6/J mice and germline transmission was confirmed by Southern blotting of tail DNA (see Figure 1B).
T34368	58972-58980	NNS	denotes	Chimeras
T34369	58986-58991	VBN	denotes	mated
T34370	58981-58985	VBD	denotes	were
T34371	58992-58994	IN	denotes	to
T34372	58995-59001	NN	denotes	C57BL6
T34373	59002-59003	NN	denotes	J
T34374	59001-59002	HYPH	denotes	/
T34375	59004-59008	NNS	denotes	mice
T34376	59009-59012	CC	denotes	and
T34377	59013-59021	NN	denotes	germline
T34378	59022-59034	NN	denotes	transmission
T34379	59039-59048	VBN	denotes	confirmed
T34380	59035-59038	VBD	denotes	was
T34381	59049-59051	IN	denotes	by
T34382	59052-59060	NNP	denotes	Southern
T34383	59061-59069	NN	denotes	blotting
T34384	59070-59072	IN	denotes	of
T34385	59073-59077	NN	denotes	tail
T34386	59078-59081	NN	denotes	DNA
T34387	59082-59083	-LRB-	denotes	(
T34388	59083-59086	VB	denotes	see
T34389	59087-59093	NN	denotes	Figure
T34390	59094-59096	NN	denotes	1B
T34391	59096-59097	-RRB-	denotes	)
T34392	59097-59098	.	denotes	.
T34393	59098-59189	sentence	denotes	All experiments were performed using sex- and age-matched or littermate controls as noted.
T34394	59099-59102	DT	denotes	All
T34395	59103-59114	NNS	denotes	experiments
T34396	59120-59129	VBN	denotes	performed
T34397	59115-59119	VBD	denotes	were
T34398	59130-59135	VBG	denotes	using
T34399	59136-59139	NN	denotes	sex
T34400	59149-59156	VBN	denotes	matched
T34401	59139-59140	HYPH	denotes	-
T34402	59141-59144	CC	denotes	and
T34403	59145-59148	NN	denotes	age
T34404	59148-59149	HYPH	denotes	-
T34405	59171-59179	NNS	denotes	controls
T34406	59157-59159	CC	denotes	or
T34407	59160-59170	NN	denotes	littermate
T34408	59180-59182	IN	denotes	as
T34409	59183-59188	VBN	denotes	noted
T34410	59188-59189	.	denotes	.
T35414	59191-59198	JJ	denotes	General
T35415	59206-59213	NNS	denotes	studies
T35416	59199-59205	NN	denotes	animal
T35417	59213-59465	sentence	denotes	All animal experiments and euthanasia protocols were conducted in strict accordance with the National Institutes of Health guidelines for humane treatment of animals and were reviewed and approved by the Animal Care Committee of Washington University.
T35418	59214-59217	DT	denotes	All
T35419	59225-59236	NNS	denotes	experiments
T35420	59218-59224	NN	denotes	animal
T35421	59267-59276	VBN	denotes	conducted
T35422	59237-59240	CC	denotes	and
T35423	59241-59251	NN	denotes	euthanasia
T35424	59252-59261	NNS	denotes	protocols
T35425	59262-59266	VBD	denotes	were
T35426	59277-59279	IN	denotes	in
T35427	59280-59286	JJ	denotes	strict
T35428	59287-59297	NN	denotes	accordance
T35429	59298-59302	IN	denotes	with
T35430	59303-59306	DT	denotes	the
T35431	59316-59326	NNPS	denotes	Institutes
T35432	59307-59315	NNP	denotes	National
T35433	59337-59347	NNS	denotes	guidelines
T35434	59327-59329	IN	denotes	of
T35435	59330-59336	NNP	denotes	Health
T35436	59348-59351	IN	denotes	for
T35437	59352-59358	NN	denotes	humane
T35438	59359-59368	NN	denotes	treatment
T35439	59369-59371	IN	denotes	of
T35440	59372-59379	NNS	denotes	animals
T35441	59380-59383	CC	denotes	and
T35442	59384-59388	VBD	denotes	were
T35443	59389-59397	VBN	denotes	reviewed
T35444	59398-59401	CC	denotes	and
T35445	59402-59410	VBN	denotes	approved
T35446	59411-59413	IN	denotes	by
T35447	59414-59417	DT	denotes	the
T35448	59430-59439	NNP	denotes	Committee
T35449	59418-59424	NNP	denotes	Animal
T35450	59425-59429	NNP	denotes	Care
T35451	59440-59442	IN	denotes	of
T35452	59443-59453	NNP	denotes	Washington
T35453	59454-59464	NNP	denotes	University
T35454	59464-59465	.	denotes	.
T35455	59465-59512	sentence	denotes	Animals were weighed at different time points.
T35456	59466-59473	NNS	denotes	Animals
T35457	59479-59486	VBN	denotes	weighed
T35458	59474-59478	VBD	denotes	were
T35459	59487-59489	IN	denotes	at
T35460	59490-59499	JJ	denotes	different
T35461	59505-59511	NNS	denotes	points
T35462	59500-59504	NN	denotes	time
T35463	59511-59512	.	denotes	.
T35464	59512-59654	sentence	denotes	Male and female 3- to 8-wk-old PGC-1α+/+ and PGC-1α−/− mice were euthanized, and tissues were dissected and weighed on an analytical balance.
T35465	59513-59517	JJ	denotes	Male
T35466	59568-59572	NNS	denotes	mice
T35467	59518-59521	CC	denotes	and
T35468	59522-59528	JJ	denotes	female
T35469	59529-59530	CD	denotes	3
T35470	59535-59536	CD	denotes	8
T35471	59530-59531	HYPH	denotes	-
T35472	59532-59534	IN	denotes	to
T35473	59537-59539	NN	denotes	wk
T35474	59536-59537	HYPH	denotes	-
T35475	59540-59543	JJ	denotes	old
T35476	59539-59540	HYPH	denotes	-
T35477	59544-59547	NN	denotes	PGC
T35478	59548-59550	NN	denotes	1α
T35479	59547-59548	HYPH	denotes	-
T35480	59550-59551	SYM	denotes	+
T35481	59551-59552	HYPH	denotes	/
T35482	59552-59553	SYM	denotes	+
T35483	59554-59557	CC	denotes	and
T35484	59558-59561	NN	denotes	PGC
T35485	59562-59564	NN	denotes	1α
T35486	59561-59562	HYPH	denotes	-
T35487	59564-59565	SYM	denotes	−
T35488	59565-59566	HYPH	denotes	/
T35489	59566-59567	SYM	denotes	−
T35490	59578-59588	VBN	denotes	euthanized
T35491	59573-59577	VBD	denotes	were
T35492	59588-59590	,	denotes	,
T35493	59590-59593	CC	denotes	and
T35494	59594-59601	NNS	denotes	tissues
T35495	59607-59616	VBN	denotes	dissected
T35496	59602-59606	VBD	denotes	were
T35497	59617-59620	CC	denotes	and
T35498	59621-59628	VBN	denotes	weighed
T35499	59629-59631	IN	denotes	on
T35500	59632-59634	DT	denotes	an
T35501	59646-59653	NN	denotes	balance
T35502	59635-59645	JJ	denotes	analytical
T35503	59653-59654	.	denotes	.
T35504	59654-59725	sentence	denotes	Tissue weights were corrected for total body weight before comparison.
T35505	59655-59661	NN	denotes	Tissue
T35506	59662-59669	NNS	denotes	weights
T35507	59675-59684	VBN	denotes	corrected
T35508	59670-59674	VBD	denotes	were
T35509	59685-59688	IN	denotes	for
T35510	59689-59694	JJ	denotes	total
T35511	59700-59706	NN	denotes	weight
T35512	59695-59699	NN	denotes	body
T35513	59707-59713	IN	denotes	before
T35514	59714-59724	NN	denotes	comparison
T35515	59724-59725	.	denotes	.
T35516	59725-59886	sentence	denotes	DEXA studies were performed as previously described [39] using a Lunar PIXIMUS DEXA system at 10, 18, and 24 wk in male and female PGC-1α+/+ and PGC-1α−/− mice.
T35517	59726-59730	NN	denotes	DEXA
T35518	59731-59738	NNS	denotes	studies
T35519	59744-59753	VBN	denotes	performed
T35520	59739-59743	VBD	denotes	were
T35521	59754-59756	IN	denotes	as
T35522	59768-59777	VBN	denotes	described
T35523	59757-59767	RB	denotes	previously
T35524	59778-59779	-LRB-	denotes	[
T35525	59779-59781	CD	denotes	39
T35526	59781-59782	-RRB-	denotes	]
T35527	59783-59788	VBG	denotes	using
T35528	59789-59790	DT	denotes	a
T35529	59810-59816	NN	denotes	system
T35530	59791-59796	NNP	denotes	Lunar
T35531	59797-59804	NNP	denotes	PIXIMUS
T35532	59805-59809	NNP	denotes	DEXA
T35533	59817-59819	IN	denotes	at
T35534	59820-59822	CD	denotes	10
T35535	59835-59837	NN	denotes	wk
T35536	59822-59824	,	denotes	,
T35537	59824-59826	CD	denotes	18
T35538	59826-59828	,	denotes	,
T35539	59828-59831	CC	denotes	and
T35540	59832-59834	CD	denotes	24
T35541	59838-59840	IN	denotes	in
T35542	59841-59845	JJ	denotes	male
T35543	59881-59885	NNS	denotes	mice
T35544	59846-59849	CC	denotes	and
T35545	59850-59856	JJ	denotes	female
T35546	59857-59860	NN	denotes	PGC
T35547	59861-59863	NN	denotes	1α
T35548	59860-59861	HYPH	denotes	-
T35549	59863-59864	SYM	denotes	+
T35550	59864-59865	HYPH	denotes	/
T35551	59865-59866	SYM	denotes	+
T35552	59867-59870	CC	denotes	and
T35553	59871-59874	NN	denotes	PGC
T35554	59875-59877	NN	denotes	1α
T35555	59874-59875	HYPH	denotes	-
T35556	59877-59878	SYM	denotes	−
T35557	59878-59879	HYPH	denotes	/
T35558	59879-59880	SYM	denotes	−
T35559	59885-59886	.	denotes	.
T35560	59886-60022	sentence	denotes	For cold exposure experiments, male and female PGC-1α+/+ and PGC-1α−/− mice were singly housed and placed at 4 °C for 5 h without food.
T35561	59887-59890	IN	denotes	For
T35562	59975-59981	VBN	denotes	housed
T35563	59891-59895	NN	denotes	cold
T35564	59905-59916	NNS	denotes	experiments
T35565	59896-59904	NN	denotes	exposure
T35566	59916-59918	,	denotes	,
T35567	59918-59922	JJ	denotes	male
T35568	59958-59962	NNS	denotes	mice
T35569	59923-59926	CC	denotes	and
T35570	59927-59933	JJ	denotes	female
T35571	59934-59937	NN	denotes	PGC
T35572	59938-59940	NN	denotes	1α
T35573	59937-59938	HYPH	denotes	-
T35574	59940-59941	SYM	denotes	+
T35575	59941-59942	HYPH	denotes	/
T35576	59942-59943	SYM	denotes	+
T35577	59944-59947	CC	denotes	and
T35578	59948-59951	NN	denotes	PGC
T35579	59952-59954	NN	denotes	1α
T35580	59951-59952	HYPH	denotes	-
T35581	59954-59955	SYM	denotes	−
T35582	59955-59956	HYPH	denotes	/
T35583	59956-59957	SYM	denotes	−
T35584	59963-59967	VBD	denotes	were
T35585	59968-59974	RB	denotes	singly
T35586	59982-59985	CC	denotes	and
T35587	59986-59992	VBN	denotes	placed
T35588	59993-59995	IN	denotes	at
T35589	59996-59997	CD	denotes	4
T35590	59998-60000	NN	denotes	°C
T35591	60001-60004	IN	denotes	for
T35592	60005-60006	CD	denotes	5
T35593	60007-60008	NN	denotes	h
T35594	60009-60016	IN	denotes	without
T35595	60017-60021	NN	denotes	food
T35596	60021-60022	.	denotes	.
T35597	60022-60115	sentence	denotes	Core body temperatures were monitored by rectal probe at baseline and every hour thereafter.
T35598	60023-60027	NN	denotes	Core
T35599	60033-60045	NNS	denotes	temperatures
T35600	60028-60032	NN	denotes	body
T35601	60051-60060	VBN	denotes	monitored
T35602	60046-60050	VBD	denotes	were
T35603	60061-60063	IN	denotes	by
T35604	60064-60070	JJ	denotes	rectal
T35605	60071-60076	NN	denotes	probe
T35606	60077-60079	IN	denotes	at
T35607	60080-60088	NN	denotes	baseline
T35608	60089-60092	CC	denotes	and
T35609	60093-60098	DT	denotes	every
T35610	60099-60103	NN	denotes	hour
T35611	60104-60114	RB	denotes	thereafter
T35612	60114-60115	.	denotes	.
T35613	60115-60180	sentence	denotes	Mice were monitored at least every 30 min to check for lethargy.
T35614	60116-60120	NNS	denotes	Mice
T35615	60126-60135	VBN	denotes	monitored
T35616	60121-60125	VBD	denotes	were
T35617	60136-60138	RB	denotes	at
T35618	60139-60144	RBS	denotes	least
T35619	60154-60157	NN	denotes	min
T35620	60145-60150	DT	denotes	every
T35621	60151-60153	CD	denotes	30
T35622	60158-60160	TO	denotes	to
T35623	60161-60166	VB	denotes	check
T35624	60167-60170	IN	denotes	for
T35625	60171-60179	NN	denotes	lethargy
T35626	60179-60180	.	denotes	.
T35627	60180-60274	sentence	denotes	At the end of 5 h, mice were sacrificed and tissues harvested for RNA and protein extraction.
T35628	60181-60183	IN	denotes	At
T35629	60210-60220	VBN	denotes	sacrificed
T35630	60184-60187	DT	denotes	the
T35631	60188-60191	NN	denotes	end
T35632	60192-60194	IN	denotes	of
T35633	60195-60196	CD	denotes	5
T35634	60197-60198	NN	denotes	h
T35635	60198-60200	,	denotes	,
T35636	60200-60204	NNS	denotes	mice
T35637	60205-60209	VBD	denotes	were
T35638	60221-60224	CC	denotes	and
T35639	60225-60232	NNS	denotes	tissues
T35640	60233-60242	VBN	denotes	harvested
T35641	60243-60246	IN	denotes	for
T35642	60247-60250	NN	denotes	RNA
T35643	60263-60273	NN	denotes	extraction
T35644	60251-60254	CC	denotes	and
T35645	60255-60262	NN	denotes	protein
T35646	60273-60274	.	denotes	.
T35647	60274-60350	sentence	denotes	For fasting studies, animals were singly housed and given water ad libitum.
T35648	60275-60278	IN	denotes	For
T35649	60316-60322	VBN	denotes	housed
T35650	60279-60286	NN	denotes	fasting
T35651	60287-60294	NNS	denotes	studies
T35652	60294-60296	,	denotes	,
T35653	60296-60303	NNS	denotes	animals
T35654	60304-60308	VBD	denotes	were
T35655	60309-60315	RB	denotes	singly
T35656	60323-60326	CC	denotes	and
T35657	60327-60332	VBN	denotes	given
T35658	60333-60338	NN	denotes	water
T35659	60339-60341	FW	denotes	ad
T35660	60342-60349	FW	denotes	libitum
T35661	60349-60350	.	denotes	.
T35662	60350-60446	sentence	denotes	Food was removed from cages in the morning and tissues harvested at 24 h for RNA and histology.
T35663	60351-60355	NN	denotes	Food
T35664	60360-60367	VBN	denotes	removed
T35665	60356-60359	VBD	denotes	was
T35666	60368-60372	IN	denotes	from
T35667	60373-60378	NNS	denotes	cages
T35668	60379-60381	IN	denotes	in
T35669	60382-60385	DT	denotes	the
T35670	60386-60393	NN	denotes	morning
T35671	60394-60397	CC	denotes	and
T35672	60398-60405	NNS	denotes	tissues
T35673	60406-60415	VBN	denotes	harvested
T35674	60416-60418	IN	denotes	at
T35675	60419-60421	CD	denotes	24
T35676	60422-60423	NN	denotes	h
T35677	60424-60427	IN	denotes	for
T35678	60428-60431	NN	denotes	RNA
T35679	60432-60435	CC	denotes	and
T35680	60436-60445	NN	denotes	histology
T35681	60445-60446	.	denotes	.
T35682	60446-60539	sentence	denotes	Photography of the mice was performed by MedPic at Washington University School of Medicine.
T35683	60447-60458	NN	denotes	Photography
T35684	60475-60484	VBN	denotes	performed
T35685	60459-60461	IN	denotes	of
T35686	60462-60465	DT	denotes	the
T35687	60466-60470	NNS	denotes	mice
T35688	60471-60474	VBD	denotes	was
T35689	60485-60487	IN	denotes	by
T35690	60488-60494	NNP	denotes	MedPic
T35691	60495-60497	IN	denotes	at
T35692	60498-60508	NNP	denotes	Washington
T35693	60509-60519	NNP	denotes	University
T35694	60520-60526	NNP	denotes	School
T35695	60527-60529	IN	denotes	of
T35696	60530-60538	NNP	denotes	Medicine
T35697	60538-60539	.	denotes	.
T35698	60539-60783	sentence	denotes	48-h activity monitoring was performed by JAX Services (The Jackson Laboratory, West Sacramento, California, United States) using a Comprehensive Laboratory Animal Monitoring System (CLAMS, Columbus Instruments, Columbus, Ohio, United States).
T35699	60540-60542	CD	denotes	48
T35700	60543-60544	NN	denotes	h
T35701	60542-60543	HYPH	denotes	-
T35702	60554-60564	NN	denotes	monitoring
T35703	60545-60553	NN	denotes	activity
T35704	60569-60578	VBN	denotes	performed
T35705	60565-60568	VBD	denotes	was
T35706	60579-60581	IN	denotes	by
T35707	60582-60585	NNP	denotes	JAX
T35708	60586-60594	NNPS	denotes	Services
T35709	60595-60596	-LRB-	denotes	(
T35710	60608-60618	NNP	denotes	Laboratory
T35711	60596-60599	DT	denotes	The
T35712	60600-60607	NNP	denotes	Jackson
T35713	60618-60620	,	denotes	,
T35714	60620-60624	NNP	denotes	West
T35715	60625-60635	NNP	denotes	Sacramento
T35716	60635-60637	,	denotes	,
T35717	60637-60647	NNP	denotes	California
T35718	60647-60649	,	denotes	,
T35719	60649-60655	NNP	denotes	United
T35720	60656-60662	NNP	denotes	States
T35721	60662-60663	-RRB-	denotes	)
T35722	60664-60669	VBG	denotes	using
T35723	60670-60671	DT	denotes	a
T35724	60715-60721	NNP	denotes	System
T35725	60672-60685	NNP	denotes	Comprehensive
T35726	60686-60696	NNP	denotes	Laboratory
T35727	60697-60703	NNP	denotes	Animal
T35728	60704-60714	NNP	denotes	Monitoring
T35729	60722-60723	-LRB-	denotes	(
T35730	60723-60728	NNP	denotes	CLAMS
T35731	60728-60730	,	denotes	,
T35732	60730-60738	NNP	denotes	Columbus
T35733	60739-60750	NNP	denotes	Instruments
T35734	60750-60752	,	denotes	,
T35735	60752-60760	NNP	denotes	Columbus
T35736	60760-60762	,	denotes	,
T35737	60762-60766	NNP	denotes	Ohio
T35738	60766-60768	,	denotes	,
T35739	60768-60774	NNP	denotes	United
T35740	60775-60781	NNP	denotes	States
T35741	60781-60782	-RRB-	denotes	)
T35742	60782-60783	.	denotes	.
T35743	60783-60862	sentence	denotes	Briefly, 3-mo-old female mice were acclimated for 17 h before data collection.
T35744	60784-60791	RB	denotes	Briefly
T35745	60819-60829	VBN	denotes	acclimated
T35746	60791-60793	,	denotes	,
T35747	60793-60794	CD	denotes	3
T35748	60795-60797	NN	denotes	mo
T35749	60794-60795	HYPH	denotes	-
T35750	60798-60801	JJ	denotes	old
T35751	60797-60798	HYPH	denotes	-
T35752	60809-60813	NNS	denotes	mice
T35753	60802-60808	JJ	denotes	female
T35754	60814-60818	VBD	denotes	were
T35755	60830-60833	IN	denotes	for
T35756	60834-60836	CD	denotes	17
T35757	60837-60838	NN	denotes	h
T35758	60839-60845	IN	denotes	before
T35759	60846-60850	NNS	denotes	data
T35760	60851-60861	NN	denotes	collection
T35761	60861-60862	.	denotes	.
T35762	60862-60896	sentence	denotes	Data were collected every 30 min.
T35763	60863-60867	NNS	denotes	Data
T35764	60873-60882	VBN	denotes	collected
T35765	60868-60872	VBD	denotes	were
T35766	60883-60888	DT	denotes	every
T35767	60892-60895	NN	denotes	min
T35768	60889-60891	CD	denotes	30
T35769	60895-60896	.	denotes	.
T35770	60896-61015	sentence	denotes	Total beam breaks in the XY direction were tabulated for the 12-h light and dark cycles and compared across genotypes.
T35771	60897-60902	JJ	denotes	Total
T35772	60908-60914	NNS	denotes	breaks
T35773	60903-60907	NN	denotes	beam
T35774	60940-60949	VBN	denotes	tabulated
T35775	60915-60917	IN	denotes	in
T35776	60918-60921	DT	denotes	the
T35777	60925-60934	NN	denotes	direction
T35778	60922-60924	NN	denotes	XY
T35779	60935-60939	VBD	denotes	were
T35780	60950-60953	IN	denotes	for
T35781	60954-60957	DT	denotes	the
T35782	60978-60984	NNS	denotes	cycles
T35783	60958-60960	CD	denotes	12
T35784	60961-60962	NN	denotes	h
T35785	60960-60961	HYPH	denotes	-
T35786	60963-60968	NN	denotes	light
T35787	60969-60972	CC	denotes	and
T35788	60973-60977	NN	denotes	dark
T35789	60985-60988	CC	denotes	and
T35790	60989-60997	VBN	denotes	compared
T35791	60998-61004	IN	denotes	across
T35792	61005-61014	NNS	denotes	genotypes
T35793	61014-61015	.	denotes	.
T36774	61017-61020	NN	denotes	RNA
T36775	61039-61047	NNS	denotes	analyses
T36776	61020-61022	,	denotes	,
T36777	61022-61025	NN	denotes	DNA
T36778	61025-61027	,	denotes	,
T36779	61027-61030	CC	denotes	and
T36780	61031-61038	NN	denotes	protein
T36781	61047-61188	sentence	denotes	Total RNA was isolated by the RNAzol method (Tel-Test, Friendswood, Texas) and Northern blotting was performed as previously described [40].
T36782	61048-61053	JJ	denotes	Total
T36783	61054-61057	NN	denotes	RNA
T36784	61062-61070	VBN	denotes	isolated
T36785	61058-61061	VBD	denotes	was
T36786	61071-61073	IN	denotes	by
T36787	61074-61077	DT	denotes	the
T36788	61085-61091	NN	denotes	method
T36789	61078-61084	NN	denotes	RNAzol
T36790	61092-61093	-LRB-	denotes	(
T36791	61097-61101	NNP	denotes	Test
T36792	61093-61096	NNP	denotes	Tel
T36793	61096-61097	HYPH	denotes	-
T36794	61101-61103	,	denotes	,
T36795	61103-61114	NNP	denotes	Friendswood
T36796	61114-61116	,	denotes	,
T36797	61116-61121	NNP	denotes	Texas
T36798	61121-61122	-RRB-	denotes	)
T36799	61123-61126	CC	denotes	and
T36800	61127-61135	NNP	denotes	Northern
T36801	61136-61144	NN	denotes	blotting
T36802	61149-61158	VBN	denotes	performed
T36803	61145-61148	VBD	denotes	was
T36804	61159-61161	IN	denotes	as
T36805	61173-61182	VBN	denotes	described
T36806	61162-61172	RB	denotes	previously
T36807	61183-61184	-LRB-	denotes	[
T36808	61184-61186	CD	denotes	40
T36809	61186-61187	-RRB-	denotes	]
T36810	61187-61188	.	denotes	.
T36811	61188-61292	sentence	denotes	The PGC-1β and PRC cDNAs were generous gifts from Bruce Spiegelman and Richard Scarpulla, respectively.
T36812	61189-61192	DT	denotes	The
T36813	61208-61213	NNS	denotes	cDNAs
T36814	61193-61196	NN	denotes	PGC
T36815	61197-61199	NN	denotes	1β
T36816	61196-61197	HYPH	denotes	-
T36817	61200-61203	CC	denotes	and
T36818	61204-61207	NN	denotes	PRC
T36819	61214-61218	VBD	denotes	were
T36820	61219-61227	JJ	denotes	generous
T36821	61228-61233	NNS	denotes	gifts
T36822	61234-61238	IN	denotes	from
T36823	61239-61244	NNP	denotes	Bruce
T36824	61245-61255	NNP	denotes	Spiegelman
T36825	61256-61259	CC	denotes	and
T36826	61260-61267	NNP	denotes	Richard
T36827	61268-61277	NNP	denotes	Scarpulla
T36828	61277-61279	,	denotes	,
T36829	61279-61291	RB	denotes	respectively
T36830	61291-61292	.	denotes	.
T36831	61292-61340	sentence	denotes	The UCP-1 cDNA was a gift from Daniel Ricquier.
T36832	61293-61296	DT	denotes	The
T36833	61303-61307	NN	denotes	cDNA
T36834	61297-61300	NN	denotes	UCP
T36835	61300-61301	HYPH	denotes	-
T36836	61301-61302	CD	denotes	1
T36837	61308-61311	VBD	denotes	was
T36838	61312-61313	DT	denotes	a
T36839	61314-61318	NN	denotes	gift
T36840	61319-61323	IN	denotes	from
T36841	61324-61330	NNP	denotes	Daniel
T36842	61331-61339	NNP	denotes	Ricquier
T36843	61339-61340	.	denotes	.
T36844	61340-61380	sentence	denotes	RT-PCR was performed as described [41].
T36845	61341-61343	NN	denotes	RT
T36846	61344-61347	NN	denotes	PCR
T36847	61343-61344	HYPH	denotes	-
T36848	61352-61361	VBN	denotes	performed
T36849	61348-61351	VBD	denotes	was
T36850	61362-61364	IN	denotes	as
T36851	61365-61374	VBN	denotes	described
T36852	61375-61376	-LRB-	denotes	[
T36853	61376-61378	CD	denotes	41
T36854	61378-61379	-RRB-	denotes	]
T36855	61379-61380	.	denotes	.
T36856	61380-61613	sentence	denotes	In brief, total RNA isolated from soleus muscle, BAT, and heart of 1–2-mo-old PGC-1α+/+ or PGCα−/− mice was reverse transcribed with Taqman reverse transcription reagents (Applied Biosystems, Foster City, California, United States).
T36857	61381-61383	IN	denotes	In
T36858	61497-61508	VBN	denotes	transcribed
T36859	61384-61389	JJ	denotes	brief
T36860	61389-61391	,	denotes	,
T36861	61391-61396	JJ	denotes	total
T36862	61397-61400	NN	denotes	RNA
T36863	61401-61409	VBN	denotes	isolated
T36864	61410-61414	IN	denotes	from
T36865	61415-61421	NN	denotes	soleus
T36866	61422-61428	NN	denotes	muscle
T36867	61428-61430	,	denotes	,
T36868	61430-61433	NN	denotes	BAT
T36869	61433-61435	,	denotes	,
T36870	61435-61438	CC	denotes	and
T36871	61439-61444	NN	denotes	heart
T36872	61445-61447	IN	denotes	of
T36873	61448-61449	CD	denotes	1
T36874	61450-61451	CD	denotes	2
T36875	61449-61450	SYM	denotes	–
T36876	61452-61454	NN	denotes	mo
T36877	61451-61452	HYPH	denotes	-
T36878	61455-61458	JJ	denotes	old
T36879	61454-61455	HYPH	denotes	-
T36880	61480-61484	NNS	denotes	mice
T36881	61459-61462	NN	denotes	PGC
T36882	61463-61465	NN	denotes	1α
T36883	61462-61463	HYPH	denotes	-
T36884	61465-61466	SYM	denotes	+
T36885	61466-61467	HYPH	denotes	/
T36886	61467-61468	SYM	denotes	+
T36887	61469-61471	CC	denotes	or
T36888	61472-61476	NN	denotes	PGCα
T36889	61476-61477	SYM	denotes	−
T36890	61477-61478	HYPH	denotes	/
T36891	61478-61479	SYM	denotes	−
T36892	61485-61488	VBD	denotes	was
T36893	61489-61496	RB	denotes	reverse
T36894	61509-61513	IN	denotes	with
T36895	61514-61520	NNP	denotes	Taqman
T36896	61543-61551	NNS	denotes	reagents
T36897	61521-61528	JJ	denotes	reverse
T36898	61529-61542	NN	denotes	transcription
T36899	61552-61553	-LRB-	denotes	(
T36900	61561-61571	NNP	denotes	Biosystems
T36901	61553-61560	NNP	denotes	Applied
T36902	61571-61573	,	denotes	,
T36903	61573-61579	NNP	denotes	Foster
T36904	61580-61584	NNP	denotes	City
T36905	61584-61586	,	denotes	,
T36906	61586-61596	NNP	denotes	California
T36907	61596-61598	,	denotes	,
T36908	61598-61604	NNP	denotes	United
T36909	61605-61611	NNP	denotes	States
T36910	61611-61612	-RRB-	denotes	)
T36911	61612-61613	.	denotes	.
T36912	61613-61754	sentence	denotes	Reactions were performed in triplicate in 96-well format using Taqman core reagents and a Prism 7500 Sequence Detector (Applied Biosystems).
T36913	61614-61623	NNS	denotes	Reactions
T36914	61629-61638	VBN	denotes	performed
T36915	61624-61628	VBD	denotes	were
T36916	61639-61641	IN	denotes	in
T36917	61642-61652	NN	denotes	triplicate
T36918	61653-61655	IN	denotes	in
T36919	61656-61658	CD	denotes	96
T36920	61659-61663	NN	denotes	well
T36921	61658-61659	HYPH	denotes	-
T36922	61664-61670	NN	denotes	format
T36923	61671-61676	VBG	denotes	using
T36924	61677-61683	NNP	denotes	Taqman
T36925	61689-61697	NNS	denotes	reagents
T36926	61684-61688	NN	denotes	core
T36927	61698-61701	CC	denotes	and
T36928	61702-61703	DT	denotes	a
T36929	61724-61732	NN	denotes	Detector
T36930	61704-61709	NN	denotes	Prism
T36931	61710-61714	CD	denotes	7500
T36932	61715-61723	NN	denotes	Sequence
T36933	61733-61734	-LRB-	denotes	(
T36934	61742-61752	NNP	denotes	Biosystems
T36935	61734-61741	NNP	denotes	Applied
T36936	61752-61753	-RRB-	denotes	)
T36937	61753-61754	.	denotes	.
T36938	61754-61857	sentence	denotes	The mouse-specific primer-probe sets used to detect specific gene expression can be found in Table S1.
T36939	61755-61758	DT	denotes	The
T36940	61787-61791	NNS	denotes	sets
T36941	61759-61764	NN	denotes	mouse
T36942	61765-61773	JJ	denotes	specific
T36943	61764-61765	HYPH	denotes	-
T36944	61774-61780	NN	denotes	primer
T36945	61781-61786	NN	denotes	probe
T36946	61780-61781	HYPH	denotes	-
T36947	61839-61844	VBN	denotes	found
T36948	61792-61796	VBN	denotes	used
T36949	61797-61799	TO	denotes	to
T36950	61800-61806	VB	denotes	detect
T36951	61807-61815	JJ	denotes	specific
T36952	61821-61831	NN	denotes	expression
T36953	61816-61820	NN	denotes	gene
T36954	61832-61835	MD	denotes	can
T36955	61836-61838	VB	denotes	be
T36956	61845-61847	IN	denotes	in
T36957	61848-61853	NN	denotes	Table
T36958	61854-61856	NN	denotes	S1
T36959	61856-61857	.	denotes	.
T36960	61857-61916	sentence	denotes	The primers for UCP-1 have been previously described [42].
T36961	61858-61861	DT	denotes	The
T36962	61862-61869	NNS	denotes	primers
T36963	61901-61910	VBN	denotes	described
T36964	61870-61873	IN	denotes	for
T36965	61874-61877	NN	denotes	UCP
T36966	61877-61878	HYPH	denotes	-
T36967	61878-61879	CD	denotes	1
T36968	61880-61884	VBP	denotes	have
T36969	61885-61889	VBN	denotes	been
T36970	61890-61900	RB	denotes	previously
T36971	61911-61912	-LRB-	denotes	[
T36972	61912-61914	CD	denotes	42
T36973	61914-61915	-RRB-	denotes	]
T36974	61915-61916	.	denotes	.
T36975	61916-62063	sentence	denotes	Actin primer-probe set (Applied Biosystems) was included in a separate well and used to normalize the soleus, BAT, and heart gene expression data.
T36976	61917-61922	NN	denotes	Actin
T36977	61936-61939	NN	denotes	set
T36978	61923-61929	NN	denotes	primer
T36979	61930-61935	NN	denotes	probe
T36980	61929-61930	HYPH	denotes	-
T36981	61965-61973	VBN	denotes	included
T36982	61940-61941	-LRB-	denotes	(
T36983	61949-61959	NNP	denotes	Biosystems
T36984	61941-61948	NNP	denotes	Applied
T36985	61959-61960	-RRB-	denotes	)
T36986	61961-61964	VBD	denotes	was
T36987	61974-61976	IN	denotes	in
T36988	61977-61978	DT	denotes	a
T36989	61988-61992	NN	denotes	well
T36990	61979-61987	JJ	denotes	separate
T36991	61993-61996	CC	denotes	and
T36992	61997-62001	VBN	denotes	used
T36993	62002-62004	TO	denotes	to
T36994	62005-62014	VB	denotes	normalize
T36995	62015-62018	DT	denotes	the
T36996	62058-62062	NNS	denotes	data
T36997	62019-62025	NN	denotes	soleus
T36998	62025-62027	,	denotes	,
T36999	62027-62030	NN	denotes	BAT
T37000	62030-62032	,	denotes	,
T37001	62032-62035	CC	denotes	and
T37002	62036-62041	NN	denotes	heart
T37003	62042-62046	NN	denotes	gene
T37004	62047-62057	NN	denotes	expression
T37005	62062-62063	.	denotes	.
T37006	62063-62177	sentence	denotes	GAPDH Rodent primers (Applied Biosystems) were used in the same well to normalize the liver gene expression data.
T37007	62064-62069	NN	denotes	GAPDH
T37008	62077-62084	NNS	denotes	primers
T37009	62070-62076	NN	denotes	Rodent
T37010	62111-62115	VBN	denotes	used
T37011	62085-62086	-LRB-	denotes	(
T37012	62094-62104	NNP	denotes	Biosystems
T37013	62086-62093	NNP	denotes	Applied
T37014	62104-62105	-RRB-	denotes	)
T37015	62106-62110	VBD	denotes	were
T37016	62116-62118	IN	denotes	in
T37017	62119-62122	DT	denotes	the
T37018	62128-62132	NN	denotes	well
T37019	62123-62127	JJ	denotes	same
T37020	62133-62135	TO	denotes	to
T37021	62136-62145	VB	denotes	normalize
T37022	62146-62149	DT	denotes	the
T37023	62172-62176	NNS	denotes	data
T37024	62150-62155	NN	denotes	liver
T37025	62156-62160	NN	denotes	gene
T37026	62161-62171	NN	denotes	expression
T37027	62176-62177	.	denotes	.
T37028	62177-62404	sentence	denotes	For Southern blot studies, 5 μg of genomic DNA was digested with Pst1 or Xba1, electrophoresed on a 0.8% TAE gel and transferred to a Gene Screen (Perkin Elmer, Wellesley, California, United States) membrane for hybridization.
T37029	62178-62181	IN	denotes	For
T37030	62229-62237	VBN	denotes	digested
T37031	62182-62190	NNP	denotes	Southern
T37032	62191-62195	NN	denotes	blot
T37033	62196-62203	NNS	denotes	studies
T37034	62203-62205	,	denotes	,
T37035	62205-62206	CD	denotes	5
T37036	62207-62209	NN	denotes	μg
T37037	62210-62212	IN	denotes	of
T37038	62213-62220	JJ	denotes	genomic
T37039	62221-62224	NN	denotes	DNA
T37040	62225-62228	VBD	denotes	was
T37041	62238-62242	IN	denotes	with
T37042	62243-62247	NN	denotes	Pst1
T37043	62248-62250	CC	denotes	or
T37044	62251-62255	NN	denotes	Xba1
T37045	62255-62257	,	denotes	,
T37046	62257-62272	VBN	denotes	electrophoresed
T37047	62273-62275	IN	denotes	on
T37048	62276-62277	DT	denotes	a
T37049	62287-62290	NN	denotes	gel
T37050	62278-62281	CD	denotes	0.8
T37051	62281-62282	NN	denotes	%
T37052	62283-62286	NN	denotes	TAE
T37053	62291-62294	CC	denotes	and
T37054	62295-62306	VBN	denotes	transferred
T37055	62307-62309	IN	denotes	to
T37056	62310-62311	DT	denotes	a
T37057	62377-62385	NN	denotes	membrane
T37058	62312-62316	NN	denotes	Gene
T37059	62317-62323	NN	denotes	Screen
T37060	62324-62325	-LRB-	denotes	(
T37061	62332-62337	NNP	denotes	Elmer
T37062	62325-62331	NNP	denotes	Perkin
T37063	62337-62339	,	denotes	,
T37064	62339-62348	NNP	denotes	Wellesley
T37065	62348-62350	,	denotes	,
T37066	62350-62360	NNP	denotes	California
T37067	62360-62362	,	denotes	,
T37068	62362-62368	NNP	denotes	United
T37069	62369-62375	NNP	denotes	States
T37070	62375-62376	-RRB-	denotes	)
T37071	62386-62389	IN	denotes	for
T37072	62390-62403	NN	denotes	hybridization
T37073	62403-62404	.	denotes	.
T37074	62404-62576	sentence	denotes	Western blotting was performed as described [43] using the Enhanced Chemiluminescence detection system (Amersham Pharmacia Biotech, Piscataway, New Jersey, United States).
T37075	62405-62412	NNP	denotes	Western
T37076	62413-62421	NN	denotes	blotting
T37077	62426-62435	VBN	denotes	performed
T37078	62422-62425	VBD	denotes	was
T37079	62436-62438	IN	denotes	as
T37080	62439-62448	VBN	denotes	described
T37081	62449-62450	-LRB-	denotes	[
T37082	62450-62452	CD	denotes	43
T37083	62452-62453	-RRB-	denotes	]
T37084	62454-62459	VBG	denotes	using
T37085	62460-62463	DT	denotes	the
T37086	62501-62507	NN	denotes	system
T37087	62464-62472	VBN	denotes	Enhanced
T37088	62473-62490	NN	denotes	Chemiluminescence
T37089	62491-62500	NN	denotes	detection
T37090	62508-62509	-LRB-	denotes	(
T37091	62528-62535	NNP	denotes	Biotech
T37092	62509-62517	NNP	denotes	Amersham
T37093	62518-62527	NNP	denotes	Pharmacia
T37094	62535-62537	,	denotes	,
T37095	62537-62547	NNP	denotes	Piscataway
T37096	62547-62549	,	denotes	,
T37097	62549-62552	NNP	denotes	New
T37098	62553-62559	NNP	denotes	Jersey
T37099	62559-62561	,	denotes	,
T37100	62561-62567	NNP	denotes	United
T37101	62568-62574	NNP	denotes	States
T37102	62574-62575	-RRB-	denotes	)
T37103	62575-62576	.	denotes	.
T37104	62576-62678	sentence	denotes	Ponceau S (Sigma, St. Louis, Missouri, United States) staining of the membrane was used as a control.
T37105	62577-62584	NNP	denotes	Ponceau
T37106	62585-62586	NNP	denotes	S
T37107	62631-62639	NN	denotes	staining
T37108	62587-62588	-LRB-	denotes	(
T37109	62588-62593	NNP	denotes	Sigma
T37110	62593-62595	,	denotes	,
T37111	62595-62598	NNP	denotes	St.
T37112	62599-62604	NNP	denotes	Louis
T37113	62604-62606	,	denotes	,
T37114	62606-62614	NNP	denotes	Missouri
T37115	62614-62616	,	denotes	,
T37116	62616-62622	NNP	denotes	United
T37117	62623-62629	NNP	denotes	States
T37118	62629-62630	-RRB-	denotes	)
T37119	62660-62664	VBN	denotes	used
T37120	62640-62642	IN	denotes	of
T37121	62643-62646	DT	denotes	the
T37122	62647-62655	NN	denotes	membrane
T37123	62656-62659	VBD	denotes	was
T37124	62665-62667	IN	denotes	as
T37125	62668-62669	DT	denotes	a
T37126	62670-62677	NN	denotes	control
T37127	62677-62678	.	denotes	.
T38198	62680-62693	JJ	denotes	Mitochondrial
T38199	62694-62705	NN	denotes	respiration
T38200	62706-62713	NNS	denotes	studies
T38201	62713-62875	sentence	denotes	Mitochondrial respiration was assessed in saponin-skinned soleus fibers with succinate as substrate and in the presence of rotenone as previously described [44].
T38202	62714-62727	JJ	denotes	Mitochondrial
T38203	62728-62739	NN	denotes	respiration
T38204	62744-62752	VBN	denotes	assessed
T38205	62740-62743	VBD	denotes	was
T38206	62753-62755	IN	denotes	in
T38207	62756-62763	NN	denotes	saponin
T38208	62764-62771	VBN	denotes	skinned
T38209	62763-62764	HYPH	denotes	-
T38210	62779-62785	NNS	denotes	fibers
T38211	62772-62778	NN	denotes	soleus
T38212	62786-62790	IN	denotes	with
T38213	62791-62800	NN	denotes	succinate
T38214	62801-62803	IN	denotes	as
T38215	62804-62813	NN	denotes	substrate
T38216	62814-62817	CC	denotes	and
T38217	62818-62820	IN	denotes	in
T38218	62821-62824	DT	denotes	the
T38219	62825-62833	NN	denotes	presence
T38220	62834-62836	IN	denotes	of
T38221	62837-62845	NN	denotes	rotenone
T38222	62846-62848	IN	denotes	as
T38223	62860-62869	VBN	denotes	described
T38224	62849-62859	RB	denotes	previously
T38225	62870-62871	-LRB-	denotes	[
T38226	62871-62873	CD	denotes	44
T38227	62873-62874	-RRB-	denotes	]
T38228	62874-62875	.	denotes	.
T38229	62875-62973	sentence	denotes	In brief, 3-mo-old female mice were anesthetized with chloral hydrate (400 mg/kg of body weight).
T38230	62876-62878	IN	denotes	In
T38231	62912-62924	VBN	denotes	anesthetized
T38232	62879-62884	JJ	denotes	brief
T38233	62884-62886	,	denotes	,
T38234	62886-62887	CD	denotes	3
T38235	62888-62890	NN	denotes	mo
T38236	62887-62888	HYPH	denotes	-
T38237	62891-62894	JJ	denotes	old
T38238	62890-62891	HYPH	denotes	-
T38239	62902-62906	NNS	denotes	mice
T38240	62895-62901	JJ	denotes	female
T38241	62907-62911	VBD	denotes	were
T38242	62925-62929	IN	denotes	with
T38243	62930-62937	JJ	denotes	chloral
T38244	62938-62945	NN	denotes	hydrate
T38245	62946-62947	-LRB-	denotes	(
T38246	62951-62953	NN	denotes	mg
T38247	62947-62950	CD	denotes	400
T38248	62953-62954	SYM	denotes	/
T38249	62954-62956	NN	denotes	kg
T38250	62957-62959	IN	denotes	of
T38251	62960-62964	NN	denotes	body
T38252	62965-62971	NN	denotes	weight
T38253	62971-62972	-RRB-	denotes	)
T38254	62972-62973	.	denotes	.
T38255	62973-63284	sentence	denotes	Soleus fibers were separated and then transferred to a buffer (2.77 mM K2Ca-EGTA, 7.23 mM K2EGTA, 6.56 mM MgCl2, 20 mM imidazole, 53.3 mM K-MES, 20 mM taurine, 5.3 mM ATP, 15 mM PCr, 3 mM KH2PO4, 0.5 mM DTT [pH 7.1]) supplemented with 50 μg/ml saponin and permeabilized for 30 min at 4 °C with gentle stirring.
T38256	62974-62980	NN	denotes	Soleus
T38257	62981-62987	NNS	denotes	fibers
T38258	62993-63002	VBN	denotes	separated
T38259	62988-62992	VBD	denotes	were
T38260	63003-63006	CC	denotes	and
T38261	63007-63011	RB	denotes	then
T38262	63012-63023	VBN	denotes	transferred
T38263	63024-63026	IN	denotes	to
T38264	63027-63028	DT	denotes	a
T38265	63029-63035	NN	denotes	buffer
T38266	63036-63037	-LRB-	denotes	(
T38267	63037-63041	CD	denotes	2.77
T38268	63042-63044	NN	denotes	mM
T38269	63050-63054	NN	denotes	EGTA
T38270	63045-63049	NN	denotes	K2Ca
T38271	63049-63050	HYPH	denotes	-
T38272	63054-63056	,	denotes	,
T38273	63056-63060	CD	denotes	7.23
T38274	63061-63063	NN	denotes	mM
T38275	63064-63070	NN	denotes	K2EGTA
T38276	63070-63072	,	denotes	,
T38277	63072-63076	CD	denotes	6.56
T38278	63077-63079	NN	denotes	mM
T38279	63080-63085	NN	denotes	MgCl2
T38280	63085-63087	,	denotes	,
T38281	63087-63089	CD	denotes	20
T38282	63090-63092	NN	denotes	mM
T38283	63093-63102	NN	denotes	imidazole
T38284	63102-63104	,	denotes	,
T38285	63104-63108	CD	denotes	53.3
T38286	63109-63111	NN	denotes	mM
T38287	63114-63117	NN	denotes	MES
T38288	63112-63113	NN	denotes	K
T38289	63113-63114	HYPH	denotes	-
T38290	63117-63119	,	denotes	,
T38291	63119-63121	CD	denotes	20
T38292	63122-63124	NN	denotes	mM
T38293	63125-63132	NN	denotes	taurine
T38294	63132-63134	,	denotes	,
T38295	63134-63137	CD	denotes	5.3
T38296	63138-63140	NN	denotes	mM
T38297	63141-63144	NN	denotes	ATP
T38298	63144-63146	,	denotes	,
T38299	63146-63148	CD	denotes	15
T38300	63149-63151	NN	denotes	mM
T38301	63152-63155	NN	denotes	PCr
T38302	63155-63157	,	denotes	,
T38303	63157-63158	CD	denotes	3
T38304	63159-63161	NN	denotes	mM
T38305	63162-63168	NN	denotes	KH2PO4
T38306	63168-63170	,	denotes	,
T38307	63170-63173	CD	denotes	0.5
T38308	63174-63176	NN	denotes	mM
T38309	63177-63180	NN	denotes	DTT
T38310	63181-63182	-LRB-	denotes	[
T38311	63182-63184	NN	denotes	pH
T38312	63185-63188	CD	denotes	7.1
T38313	63188-63189	-RRB-	denotes	]
T38314	63189-63190	-RRB-	denotes	)
T38315	63191-63203	VBN	denotes	supplemented
T38316	63204-63208	IN	denotes	with
T38317	63209-63211	CD	denotes	50
T38318	63212-63214	NN	denotes	μg
T38319	63214-63215	SYM	denotes	/
T38320	63218-63225	NN	denotes	saponin
T38321	63215-63217	NN	denotes	ml
T38322	63226-63229	CC	denotes	and
T38323	63230-63243	VBN	denotes	permeabilized
T38324	63244-63247	IN	denotes	for
T38325	63248-63250	CD	denotes	30
T38326	63251-63254	NN	denotes	min
T38327	63255-63257	IN	denotes	at
T38328	63258-63259	CD	denotes	4
T38329	63260-63262	NN	denotes	°C
T38330	63263-63267	IN	denotes	with
T38331	63268-63274	JJ	denotes	gentle
T38332	63275-63283	NN	denotes	stirring
T38333	63283-63284	.	denotes	.
T38334	63284-63475	sentence	denotes	Fibers were then washed twice for 10 min each (2.77 mM K2Ca-EGTA, 7.23 mM K2EGTA, 1.38 mM MgCl2, 20 mM imidazole, 100 mM K-MES, 20 mM taurine, 3 mM KH2PO4, 0.5 mM DTT, 2 mg/ml BSA [pH 7.1]).
T38335	63285-63291	NNS	denotes	Fibers
T38336	63302-63308	VBN	denotes	washed
T38337	63292-63296	VBD	denotes	were
T38338	63297-63301	RB	denotes	then
T38339	63309-63314	RB	denotes	twice
T38340	63315-63318	IN	denotes	for
T38341	63319-63321	CD	denotes	10
T38342	63322-63325	NN	denotes	min
T38343	63326-63330	RB	denotes	each
T38344	63331-63332	-LRB-	denotes	(
T38345	63345-63349	NN	denotes	EGTA
T38346	63332-63336	CD	denotes	2.77
T38347	63337-63339	NN	denotes	mM
T38348	63340-63344	NN	denotes	K2Ca
T38349	63344-63345	HYPH	denotes	-
T38350	63349-63351	,	denotes	,
T38351	63351-63355	CD	denotes	7.23
T38352	63356-63358	NN	denotes	mM
T38353	63359-63365	NN	denotes	K2EGTA
T38354	63365-63367	,	denotes	,
T38355	63367-63371	CD	denotes	1.38
T38356	63372-63374	NN	denotes	mM
T38357	63375-63380	NN	denotes	MgCl2
T38358	63380-63382	,	denotes	,
T38359	63382-63384	CD	denotes	20
T38360	63385-63387	NN	denotes	mM
T38361	63388-63397	NN	denotes	imidazole
T38362	63397-63399	,	denotes	,
T38363	63399-63402	CD	denotes	100
T38364	63403-63405	NN	denotes	mM
T38365	63408-63411	NN	denotes	MES
T38366	63406-63407	NN	denotes	K
T38367	63407-63408	HYPH	denotes	-
T38368	63411-63413	,	denotes	,
T38369	63413-63415	CD	denotes	20
T38370	63416-63418	NN	denotes	mM
T38371	63419-63426	NN	denotes	taurine
T38372	63426-63428	,	denotes	,
T38373	63428-63429	CD	denotes	3
T38374	63430-63432	NN	denotes	mM
T38375	63433-63439	NN	denotes	KH2PO4
T38376	63439-63441	,	denotes	,
T38377	63441-63444	CD	denotes	0.5
T38378	63445-63447	NN	denotes	mM
T38379	63448-63451	NN	denotes	DTT
T38380	63451-63453	,	denotes	,
T38381	63453-63454	CD	denotes	2
T38382	63455-63457	NN	denotes	mg
T38383	63457-63458	SYM	denotes	/
T38384	63461-63464	NN	denotes	BSA
T38385	63458-63460	NN	denotes	ml
T38386	63465-63466	-LRB-	denotes	[
T38387	63466-63468	NN	denotes	pH
T38388	63469-63472	CD	denotes	7.1
T38389	63472-63473	-RRB-	denotes	]
T38390	63473-63474	-RRB-	denotes	)
T38391	63474-63475	.	denotes	.
T38392	63475-63600	sentence	denotes	Respiration was measured at 25 °C using an optical probe (Oxygen FOXY Probe, Ocean Optics, Dunedin, Florida, United States).
T38393	63476-63487	NN	denotes	Respiration
T38394	63492-63500	VBN	denotes	measured
T38395	63488-63491	VBD	denotes	was
T38396	63501-63503	IN	denotes	at
T38397	63504-63506	CD	denotes	25
T38398	63507-63509	NN	denotes	°C
T38399	63510-63515	VBG	denotes	using
T38400	63516-63518	DT	denotes	an
T38401	63527-63532	NN	denotes	probe
T38402	63519-63526	JJ	denotes	optical
T38403	63533-63534	-LRB-	denotes	(
T38404	63546-63551	NNP	denotes	Probe
T38405	63534-63540	NNP	denotes	Oxygen
T38406	63541-63545	NNP	denotes	FOXY
T38407	63551-63553	,	denotes	,
T38408	63553-63558	NNP	denotes	Ocean
T38409	63559-63565	NNP	denotes	Optics
T38410	63565-63567	,	denotes	,
T38411	63567-63574	NNP	denotes	Dunedin
T38412	63574-63576	,	denotes	,
T38413	63576-63583	NNP	denotes	Florida
T38414	63583-63585	,	denotes	,
T38415	63585-63591	NNP	denotes	United
T38416	63592-63598	NNP	denotes	States
T38417	63598-63599	-RRB-	denotes	)
T38418	63599-63600	.	denotes	.
T38419	63600-63744	sentence	denotes	Following measurement of basal state 2 respiration, maximal (ADP-stimulated) state 3 respiration was determined by exposing fibers to 1 mM ADP.
T38420	63601-63610	VBG	denotes	Following
T38421	63702-63712	VBN	denotes	determined
T38422	63611-63622	NN	denotes	measurement
T38423	63623-63625	IN	denotes	of
T38424	63626-63631	JJ	denotes	basal
T38425	63640-63651	NN	denotes	respiration
T38426	63632-63637	NN	denotes	state
T38427	63638-63639	CD	denotes	2
T38428	63651-63653	,	denotes	,
T38429	63653-63660	JJ	denotes	maximal
T38430	63686-63697	NN	denotes	respiration
T38431	63661-63662	-LRB-	denotes	(
T38432	63662-63665	NN	denotes	ADP
T38433	63666-63676	VBN	denotes	stimulated
T38434	63665-63666	HYPH	denotes	-
T38435	63676-63677	-RRB-	denotes	)
T38436	63678-63683	NN	denotes	state
T38437	63684-63685	CD	denotes	3
T38438	63698-63701	VBD	denotes	was
T38439	63713-63715	IN	denotes	by
T38440	63716-63724	VBG	denotes	exposing
T38441	63725-63731	NNS	denotes	fibers
T38442	63732-63734	IN	denotes	to
T38443	63735-63736	CD	denotes	1
T38444	63737-63739	NN	denotes	mM
T38445	63740-63743	NN	denotes	ADP
T38446	63743-63744	.	denotes	.
T38447	63744-63871	sentence	denotes	The integrity of the outer mitochondrial membrane was assessed by adding 8 μM exogenous cytochrome c to ADP-stimulated fibers.
T38448	63745-63748	DT	denotes	The
T38449	63749-63758	NN	denotes	integrity
T38450	63799-63807	VBN	denotes	assessed
T38451	63759-63761	IN	denotes	of
T38452	63762-63765	DT	denotes	the
T38453	63786-63794	NN	denotes	membrane
T38454	63766-63771	JJ	denotes	outer
T38455	63772-63785	JJ	denotes	mitochondrial
T38456	63795-63798	VBD	denotes	was
T38457	63808-63810	IN	denotes	by
T38458	63811-63817	VBG	denotes	adding
T38459	63818-63819	CD	denotes	8
T38460	63820-63822	NN	denotes	μM
T38461	63844-63845	NN	denotes	c
T38462	63823-63832	JJ	denotes	exogenous
T38463	63833-63843	NN	denotes	cytochrome
T38464	63846-63848	IN	denotes	to
T38465	63849-63852	NN	denotes	ADP
T38466	63853-63863	VBN	denotes	stimulated
T38467	63852-63853	HYPH	denotes	-
T38468	63864-63870	NNS	denotes	fibers
T38469	63870-63871	.	denotes	.
T38470	63871-63961	sentence	denotes	State 4 respiration (uncoupled) was evaluated following addition of oligomycin (1 μg/ml).
T38471	63872-63877	NN	denotes	State
T38472	63880-63891	NN	denotes	respiration
T38473	63878-63879	CD	denotes	4
T38474	63908-63917	VBN	denotes	evaluated
T38475	63892-63893	-LRB-	denotes	(
T38476	63893-63902	JJ	denotes	uncoupled
T38477	63902-63903	-RRB-	denotes	)
T38478	63904-63907	VBD	denotes	was
T38479	63918-63927	VBG	denotes	following
T38480	63928-63936	NN	denotes	addition
T38481	63937-63939	IN	denotes	of
T38482	63940-63950	NN	denotes	oligomycin
T38483	63951-63952	-LRB-	denotes	(
T38484	63954-63956	NN	denotes	μg
T38485	63952-63953	CD	denotes	1
T38486	63956-63957	SYM	denotes	/
T38487	63957-63959	NN	denotes	ml
T38488	63959-63960	-RRB-	denotes	)
T38489	63960-63961	.	denotes	.
T38490	63961-64057	sentence	denotes	The solubility of oxygen in the respiration buffer at 25 °C was taken as 246.87 nmol O2 · ml−1.
T38491	63962-63965	DT	denotes	The
T38492	63966-63976	NN	denotes	solubility
T38493	64026-64031	VBN	denotes	taken
T38494	63977-63979	IN	denotes	of
T38495	63980-63986	NN	denotes	oxygen
T38496	63987-63989	IN	denotes	in
T38497	63990-63993	DT	denotes	the
T38498	64006-64012	NN	denotes	buffer
T38499	63994-64005	NN	denotes	respiration
T38500	64013-64015	IN	denotes	at
T38501	64016-64018	CD	denotes	25
T38502	64019-64021	NN	denotes	°C
T38503	64022-64025	VBD	denotes	was
T38504	64032-64034	IN	denotes	as
T38505	64035-64041	CD	denotes	246.87
T38506	64042-64046	NN	denotes	nmol
T38507	64047-64049	NN	denotes	O2
T38508	64050-64051	SYM	denotes	·
T38509	64052-64054	NN	denotes	ml
T38510	64054-64055	SYM	denotes	−
T38511	64055-64056	CD	denotes	1
T38512	64056-64057	.	denotes	.
T38513	64057-64119	sentence	denotes	Respiration rates were expressed as nmol O2 · min−1 · mgdw−1.
T38514	64058-64069	NN	denotes	Respiration
T38515	64070-64075	NNS	denotes	rates
T38516	64081-64090	VBN	denotes	expressed
T38517	64076-64080	VBD	denotes	were
T38518	64091-64093	IN	denotes	as
T38519	64094-64098	NN	denotes	nmol
T38520	64099-64101	NN	denotes	O2
T38521	64102-64103	SYM	denotes	·
T38522	64104-64107	NN	denotes	min
T38523	64107-64108	SYM	denotes	−
T38524	64108-64109	CD	denotes	1
T38525	64110-64111	SYM	denotes	·
T38526	64112-64116	NN	denotes	mgdw
T38527	64116-64117	SYM	denotes	−
T38528	64117-64118	CD	denotes	1
T38529	64118-64119	.	denotes	.
T38945	64121-64128	NN	denotes	Insulin
T38946	64141-64150	NN	denotes	tolerance
T38947	64129-64132	CC	denotes	and
T38948	64133-64140	NN	denotes	glucose
T38949	64151-64156	NNS	denotes	tests
T38950	64156-64226	sentence	denotes	Glucose and Insulin tolerance tests were performed as described [35].
T38951	64157-64164	NN	denotes	Glucose
T38952	64177-64186	NN	denotes	tolerance
T38953	64165-64168	CC	denotes	and
T38954	64169-64176	NN	denotes	Insulin
T38955	64187-64192	NNS	denotes	tests
T38956	64198-64207	VBN	denotes	performed
T38957	64193-64197	VBD	denotes	were
T38958	64208-64210	IN	denotes	as
T38959	64211-64220	VBN	denotes	described
T38960	64221-64222	-LRB-	denotes	[
T38961	64222-64224	CD	denotes	35
T38962	64224-64225	-RRB-	denotes	]
T38963	64225-64226	.	denotes	.
T38964	64226-64291	sentence	denotes	Prior to studies, mice were fasted overnight (GTT) or 6 h (ITT).
T38965	64227-64232	JJ	denotes	Prior
T38966	64233-64235	IN	denotes	to
T38967	64255-64261	VBN	denotes	fasted
T38968	64236-64243	NNS	denotes	studies
T38969	64243-64245	,	denotes	,
T38970	64245-64249	NNS	denotes	mice
T38971	64250-64254	VBD	denotes	were
T38972	64262-64271	RB	denotes	overnight
T38973	64283-64284	NN	denotes	h
T38974	64272-64273	-LRB-	denotes	(
T38975	64273-64276	NN	denotes	GTT
T38976	64276-64277	-RRB-	denotes	)
T38977	64278-64280	CC	denotes	or
T38978	64281-64282	CD	denotes	6
T38979	64285-64286	-LRB-	denotes	(
T38980	64286-64289	NN	denotes	ITT
T38981	64289-64290	-RRB-	denotes	)
T38982	64290-64291	.	denotes	.
T38983	64291-64369	sentence	denotes	In GTT studies, mice were injected with a 10% solution of D-glucose (1 g/kg).
T38984	64292-64294	IN	denotes	In
T38985	64318-64326	VBN	denotes	injected
T38986	64295-64298	NN	denotes	GTT
T38987	64299-64306	NNS	denotes	studies
T38988	64306-64308	,	denotes	,
T38989	64308-64312	NNS	denotes	mice
T38990	64313-64317	VBD	denotes	were
T38991	64327-64331	IN	denotes	with
T38992	64332-64333	DT	denotes	a
T38993	64338-64346	NN	denotes	solution
T38994	64334-64336	CD	denotes	10
T38995	64336-64337	NN	denotes	%
T38996	64347-64349	IN	denotes	of
T38997	64350-64351	NN	denotes	D
T38998	64352-64359	NN	denotes	glucose
T38999	64351-64352	HYPH	denotes	-
T39000	64360-64361	-LRB-	denotes	(
T39001	64363-64364	NN	denotes	g
T39002	64361-64362	CD	denotes	1
T39003	64364-64365	SYM	denotes	/
T39004	64365-64367	NN	denotes	kg
T39005	64367-64368	-RRB-	denotes	)
T39006	64368-64369	.	denotes	.
T39007	64369-64526	sentence	denotes	For ITT, mice received an IP injection of human regular insulin (Eli Lilly, Indianapolis, Indiana, United States) at a dose of 0.75 units/kg of body weight.
T39008	64370-64373	IN	denotes	For
T39009	64384-64392	VBD	denotes	received
T39010	64374-64377	NN	denotes	ITT
T39011	64377-64379	,	denotes	,
T39012	64379-64383	NNS	denotes	mice
T39013	64393-64395	DT	denotes	an
T39014	64399-64408	NN	denotes	injection
T39015	64396-64398	NN	denotes	IP
T39016	64409-64411	IN	denotes	of
T39017	64412-64417	JJ	denotes	human
T39018	64426-64433	NN	denotes	insulin
T39019	64418-64425	JJ	denotes	regular
T39020	64434-64435	-LRB-	denotes	(
T39021	64439-64444	NNP	denotes	Lilly
T39022	64435-64438	NNP	denotes	Eli
T39023	64444-64446	,	denotes	,
T39024	64446-64458	NNP	denotes	Indianapolis
T39025	64458-64460	,	denotes	,
T39026	64460-64467	NNP	denotes	Indiana
T39027	64467-64469	,	denotes	,
T39028	64469-64475	NNP	denotes	United
T39029	64476-64482	NNP	denotes	States
T39030	64482-64483	-RRB-	denotes	)
T39031	64484-64486	IN	denotes	at
T39032	64487-64488	DT	denotes	a
T39033	64489-64493	NN	denotes	dose
T39034	64494-64496	IN	denotes	of
T39035	64497-64501	CD	denotes	0.75
T39036	64502-64507	NNS	denotes	units
T39037	64507-64508	SYM	denotes	/
T39038	64508-64510	NN	denotes	kg
T39039	64511-64513	IN	denotes	of
T39040	64514-64518	NN	denotes	body
T39041	64519-64525	NN	denotes	weight
T39042	64525-64526	.	denotes	.
T39043	64526-64662	sentence	denotes	Tail blood glucose was determined at 0, 30, 60, and 120 min after challenge using a B-GLUCOSE Analyzer (Hemacue AB, Angelholm, Sweden).
T39044	64527-64531	NN	denotes	Tail
T39045	64538-64545	NN	denotes	glucose
T39046	64532-64537	NN	denotes	blood
T39047	64550-64560	VBN	denotes	determined
T39048	64546-64549	VBD	denotes	was
T39049	64561-64563	IN	denotes	at
T39050	64564-64565	CD	denotes	0
T39051	64583-64586	NN	denotes	min
T39052	64565-64567	,	denotes	,
T39053	64567-64569	CD	denotes	30
T39054	64569-64571	,	denotes	,
T39055	64571-64573	CD	denotes	60
T39056	64573-64575	,	denotes	,
T39057	64575-64578	CC	denotes	and
T39058	64579-64582	CD	denotes	120
T39059	64587-64592	IN	denotes	after
T39060	64593-64602	NN	denotes	challenge
T39061	64603-64608	VBG	denotes	using
T39062	64609-64610	DT	denotes	a
T39063	64621-64629	NNP	denotes	Analyzer
T39064	64611-64612	NNP	denotes	B
T39065	64613-64620	NNP	denotes	GLUCOSE
T39066	64612-64613	HYPH	denotes	-
T39067	64630-64631	-LRB-	denotes	(
T39068	64639-64641	NNP	denotes	AB
T39069	64631-64638	NNP	denotes	Hemacue
T39070	64641-64643	,	denotes	,
T39071	64643-64652	NNP	denotes	Angelholm
T39072	64652-64654	,	denotes	,
T39073	64654-64660	NNP	denotes	Sweden
T39074	64660-64661	-RRB-	denotes	)
T39075	64661-64662	.	denotes	.
T45745	72807-72816	VBN	denotes	described
T45746	72796-72806	RB	denotes	previously
T39319	64664-64672	JJ	denotes	Indirect
T39320	64673-64684	NN	denotes	calorimetry
T39321	64684-64797	sentence	denotes	Oxygen consumption rates (VO2) of 5-wk-old female mice were measured using a Columbus Instruments Oxymax System.
T39322	64685-64691	NN	denotes	Oxygen
T39323	64704-64709	NNS	denotes	rates
T39324	64692-64703	NN	denotes	consumption
T39325	64745-64753	VBN	denotes	measured
T39326	64710-64711	-LRB-	denotes	(
T39327	64711-64714	NN	denotes	VO2
T39328	64714-64715	-RRB-	denotes	)
T39329	64716-64718	IN	denotes	of
T39330	64719-64720	CD	denotes	5
T39331	64721-64723	NN	denotes	wk
T39332	64720-64721	HYPH	denotes	-
T39333	64724-64727	JJ	denotes	old
T39334	64723-64724	HYPH	denotes	-
T39335	64735-64739	NNS	denotes	mice
T39336	64728-64734	JJ	denotes	female
T39337	64740-64744	VBD	denotes	were
T39338	64754-64759	VBG	denotes	using
T39339	64760-64761	DT	denotes	a
T39340	64790-64796	NNP	denotes	System
T39341	64762-64770	NNP	denotes	Columbus
T39342	64771-64782	NNPS	denotes	Instruments
T39343	64783-64789	NNP	denotes	Oxymax
T39344	64796-64797	.	denotes	.
T39345	64797-64873	sentence	denotes	Resting baseline oxygen consumption rates were assessed for at least 1.0 h.
T39346	64798-64805	NN	denotes	Resting
T39347	64834-64839	NNS	denotes	rates
T39348	64806-64814	NN	denotes	baseline
T39349	64815-64821	NN	denotes	oxygen
T39350	64822-64833	NN	denotes	consumption
T39351	64845-64853	VBN	denotes	assessed
T39352	64840-64844	VBD	denotes	were
T39353	64854-64857	IN	denotes	for
T39354	64858-64860	RB	denotes	at
T39355	64861-64866	RBS	denotes	least
T39356	64867-64870	CD	denotes	1.0
T39357	64871-64872	NN	denotes	h
T39358	64872-64873	.	denotes	.
T39359	64873-65008	sentence	denotes	For β3-adrenergic stimulation studies, BRL 37344 (Sigma) was dissolved in sterile saline and injected IP (2 μg/g of body weight) [45].
T39360	64874-64877	IN	denotes	For
T39361	64935-64944	VBN	denotes	dissolved
T39362	64878-64880	NN	denotes	β3
T39363	64881-64891	JJ	denotes	adrenergic
T39364	64880-64881	HYPH	denotes	-
T39365	64904-64911	NNS	denotes	studies
T39366	64892-64903	NN	denotes	stimulation
T39367	64911-64913	,	denotes	,
T39368	64913-64916	NN	denotes	BRL
T39369	64917-64922	CD	denotes	37344
T39370	64923-64924	-LRB-	denotes	(
T39371	64924-64929	NNP	denotes	Sigma
T39372	64929-64930	-RRB-	denotes	)
T39373	64931-64934	VBD	denotes	was
T39374	64945-64947	IN	denotes	in
T39375	64948-64955	JJ	denotes	sterile
T39376	64956-64962	NN	denotes	saline
T39377	64963-64966	CC	denotes	and
T39378	64967-64975	VBN	denotes	injected
T39379	64976-64978	RB	denotes	IP
T39380	64979-64980	-LRB-	denotes	(
T39381	64982-64984	NN	denotes	μg
T39382	64980-64981	CD	denotes	2
T39383	64984-64985	SYM	denotes	/
T39384	64985-64986	NN	denotes	g
T39385	64987-64989	IN	denotes	of
T39386	64990-64994	NN	denotes	body
T39387	64995-65001	NN	denotes	weight
T39388	65001-65002	-RRB-	denotes	)
T39389	65003-65004	-LRB-	denotes	[
T39390	65004-65006	CD	denotes	45
T39391	65006-65007	-RRB-	denotes	]
T39392	65007-65008	.	denotes	.
T39393	65008-65137	sentence	denotes	Postagonist assessment of oxygen consumption was recorded for an additional 1.0 h, with data collected at the 40-min time point.
T39394	65009-65020	NN	denotes	Postagonist
T39395	65021-65031	NN	denotes	assessment
T39396	65058-65066	VBN	denotes	recorded
T39397	65032-65034	IN	denotes	of
T39398	65035-65041	NN	denotes	oxygen
T39399	65042-65053	NN	denotes	consumption
T39400	65054-65057	VBD	denotes	was
T39401	65067-65070	IN	denotes	for
T39402	65071-65073	DT	denotes	an
T39403	65089-65090	NN	denotes	h
T39404	65074-65084	JJ	denotes	additional
T39405	65085-65088	CD	denotes	1.0
T39406	65090-65092	,	denotes	,
T39407	65092-65096	IN	denotes	with
T39408	65097-65101	NNS	denotes	data
T39409	65102-65111	VBN	denotes	collected
T39410	65112-65114	IN	denotes	at
T39411	65115-65118	DT	denotes	the
T39412	65131-65136	NN	denotes	point
T39413	65119-65121	CD	denotes	40
T39414	65122-65125	NN	denotes	min
T39415	65121-65122	HYPH	denotes	-
T39416	65126-65130	NN	denotes	time
T39417	65136-65137	.	denotes	.
T40046	65139-65148	NN	denotes	Histology
T40047	65149-65152	CC	denotes	and
T40048	65153-65161	NN	denotes	electron
T40049	65162-65172	NN	denotes	microscopy
T40050	65172-65310	sentence	denotes	Soleus muscle and liver were dissected and fixed overnight in 2% glutaraldehyde, 1% paraformaldehyde, and 0.08% sodium cacodylate buffer.
T40051	65173-65179	NN	denotes	Soleus
T40052	65180-65186	NN	denotes	muscle
T40053	65202-65211	VBN	denotes	dissected
T40054	65187-65190	CC	denotes	and
T40055	65191-65196	NN	denotes	liver
T40056	65197-65201	VBD	denotes	were
T40057	65212-65215	CC	denotes	and
T40058	65216-65221	VBN	denotes	fixed
T40059	65222-65231	RB	denotes	overnight
T40060	65232-65234	IN	denotes	in
T40061	65235-65236	CD	denotes	2
T40062	65236-65237	NN	denotes	%
T40063	65238-65252	NN	denotes	glutaraldehyde
T40064	65303-65309	NN	denotes	buffer
T40065	65252-65254	,	denotes	,
T40066	65254-65255	CD	denotes	1
T40067	65255-65256	NN	denotes	%
T40068	65257-65273	NN	denotes	paraformaldehyde
T40069	65273-65275	,	denotes	,
T40070	65275-65278	CC	denotes	and
T40071	65279-65283	CD	denotes	0.08
T40072	65283-65284	NN	denotes	%
T40073	65285-65291	NN	denotes	sodium
T40074	65292-65302	NN	denotes	cacodylate
T40075	65309-65310	.	denotes	.
T40076	65310-65466	sentence	denotes	The tissues were postfixed in 1% osmium tetroxide, dehydrated in graded ethanol, embedded in Poly Bed plastic resin, and sectioned for electron microscopy.
T40077	65311-65314	DT	denotes	The
T40078	65315-65322	NNS	denotes	tissues
T40079	65328-65337	VBN	denotes	postfixed
T40080	65323-65327	VBD	denotes	were
T40081	65338-65340	IN	denotes	in
T40082	65341-65342	CD	denotes	1
T40083	65342-65343	NN	denotes	%
T40084	65351-65360	NN	denotes	tetroxide
T40085	65344-65350	NN	denotes	osmium
T40086	65360-65362	,	denotes	,
T40087	65362-65372	VBN	denotes	dehydrated
T40088	65373-65375	IN	denotes	in
T40089	65376-65382	JJ	denotes	graded
T40090	65383-65390	NN	denotes	ethanol
T40091	65390-65392	,	denotes	,
T40092	65392-65400	VBN	denotes	embedded
T40093	65401-65403	IN	denotes	in
T40094	65404-65408	NNP	denotes	Poly
T40095	65409-65412	NNP	denotes	Bed
T40096	65421-65426	NN	denotes	resin
T40097	65413-65420	NN	denotes	plastic
T40098	65426-65428	,	denotes	,
T40099	65428-65431	CC	denotes	and
T40100	65432-65441	VBN	denotes	sectioned
T40101	65442-65445	IN	denotes	for
T40102	65446-65454	NN	denotes	electron
T40103	65455-65465	NN	denotes	microscopy
T40104	65465-65466	.	denotes	.
T45747	72817-72821	IN	denotes	with
T40105	65466-65614	sentence	denotes	Cardiac and skeletal muscle mitochondrial and myofibrillar volume densities were determined from electron micrographs as described previously [10].
T40106	65467-65474	JJ	denotes	Cardiac
T40107	65488-65494	NN	denotes	muscle
T40108	65475-65478	CC	denotes	and
T40109	65479-65487	JJ	denotes	skeletal
T40110	65533-65542	NNS	denotes	densities
T40111	65495-65508	JJ	denotes	mitochondrial
T40112	65509-65512	CC	denotes	and
T40113	65513-65525	JJ	denotes	myofibrillar
T40114	65526-65532	NN	denotes	volume
T40115	65548-65558	VBN	denotes	determined
T40116	65543-65547	VBD	denotes	were
T40117	65559-65563	IN	denotes	from
T40118	65564-65572	NN	denotes	electron
T40119	65573-65584	NNS	denotes	micrographs
T40120	65585-65587	IN	denotes	as
T40121	65588-65597	VBN	denotes	described
T40122	65598-65608	RB	denotes	previously
T40123	65609-65610	-LRB-	denotes	[
T40124	65610-65612	CD	denotes	10
T40125	65612-65613	-RRB-	denotes	]
T40126	65613-65614	.	denotes	.
T40127	65614-65720	sentence	denotes	For each animal, three different fields at the magnification of 7500× were quantified in blinded fashion.
T40128	65615-65618	IN	denotes	For
T40129	65690-65700	VBN	denotes	quantified
T40130	65619-65623	DT	denotes	each
T40131	65624-65630	NN	denotes	animal
T40132	65630-65632	,	denotes	,
T40133	65632-65637	CD	denotes	three
T40134	65648-65654	NNS	denotes	fields
T40135	65638-65647	JJ	denotes	different
T40136	65655-65657	IN	denotes	at
T40137	65658-65661	DT	denotes	the
T40138	65662-65675	NN	denotes	magnification
T40139	65676-65678	IN	denotes	of
T40140	65679-65683	NN	denotes	7500
T40141	65683-65684	SYM	denotes	×
T40142	65685-65689	VBD	denotes	were
T40143	65701-65703	IN	denotes	in
T40144	65704-65711	JJ	denotes	blinded
T40145	65712-65719	NN	denotes	fashion
T40146	65719-65720	.	denotes	.
T40147	65720-65808	sentence	denotes	Data were expressed as mean volume density of mitochondria or myofibrils in each field.
T40148	65721-65725	NNS	denotes	Data
T40149	65731-65740	VBN	denotes	expressed
T40150	65726-65730	VBD	denotes	were
T40151	65741-65743	IN	denotes	as
T40152	65744-65748	NN	denotes	mean
T40153	65756-65763	NN	denotes	density
T40154	65749-65755	NN	denotes	volume
T40155	65764-65766	IN	denotes	of
T40156	65767-65779	NNS	denotes	mitochondria
T40157	65780-65782	CC	denotes	or
T40158	65783-65793	NNS	denotes	myofibrils
T40159	65794-65796	IN	denotes	in
T40160	65797-65801	DT	denotes	each
T40161	65802-65807	NN	denotes	field
T40162	65807-65808	.	denotes	.
T40163	65808-65906	sentence	denotes	For electron microscopic analysis of the brain, tissue was prepared as previously described [46].
T40164	65809-65812	IN	denotes	For
T40165	65868-65876	VBN	denotes	prepared
T40166	65813-65821	NN	denotes	electron
T40167	65834-65842	NN	denotes	analysis
T40168	65822-65833	JJ	denotes	microscopic
T40169	65843-65845	IN	denotes	of
T40170	65846-65849	DT	denotes	the
T40171	65850-65855	NN	denotes	brain
T40172	65855-65857	,	denotes	,
T40173	65857-65863	NN	denotes	tissue
T40174	65864-65867	VBD	denotes	was
T40175	65877-65879	IN	denotes	as
T40176	65891-65900	VBN	denotes	described
T40177	65880-65890	RB	denotes	previously
T40178	65901-65902	-LRB-	denotes	[
T40179	65902-65904	CD	denotes	46
T40180	65904-65905	-RRB-	denotes	]
T40181	65905-65906	.	denotes	.
T40182	65906-66071	sentence	denotes	Ultrathin sections of cortex were cut onto formvar-coated slot grids stained with uranyl acetate and lead citrate and examined with a JEOL 1200 electron microscope.
T40183	65907-65916	JJ	denotes	Ultrathin
T40184	65917-65925	NNS	denotes	sections
T40185	65941-65944	VBN	denotes	cut
T40186	65926-65928	IN	denotes	of
T40187	65929-65935	NN	denotes	cortex
T40188	65936-65940	VBD	denotes	were
T40189	65945-65949	IN	denotes	onto
T40190	65950-65957	NN	denotes	formvar
T40191	65958-65964	VBN	denotes	coated
T40192	65957-65958	HYPH	denotes	-
T40193	65970-65975	NNS	denotes	grids
T40194	65965-65969	NN	denotes	slot
T40195	65976-65983	VBN	denotes	stained
T40196	65984-65988	IN	denotes	with
T40197	65989-65995	NN	denotes	uranyl
T40198	65996-66003	NN	denotes	acetate
T40199	66004-66007	CC	denotes	and
T40200	66008-66012	NN	denotes	lead
T40201	66013-66020	NN	denotes	citrate
T40202	66021-66024	CC	denotes	and
T40203	66025-66033	VBN	denotes	examined
T40204	66034-66038	IN	denotes	with
T40205	66039-66040	DT	denotes	a
T40206	66060-66070	NN	denotes	microscope
T40207	66041-66045	NNP	denotes	JEOL
T40208	66046-66050	CD	denotes	1200
T40209	66051-66059	NN	denotes	electron
T40210	66070-66071	.	denotes	.
T40211	66071-66279	sentence	denotes	For H&E staining, sections of brain, including cerebral cortex, brainstem, and cerebellum, were dehydrated in graded concentrations of alcohol and embedded in paraffin from which 5-μm sections were prepared.
T40212	66072-66075	IN	denotes	For
T40213	66168-66178	VBN	denotes	dehydrated
T40214	66076-66077	NN	denotes	H
T40215	66080-66088	NN	denotes	staining
T40216	66077-66078	CC	denotes	&
T40217	66078-66079	NN	denotes	E
T40218	66088-66090	,	denotes	,
T40219	66090-66098	NNS	denotes	sections
T40220	66099-66101	IN	denotes	of
T40221	66102-66107	NN	denotes	brain
T40222	66107-66109	,	denotes	,
T40223	66109-66118	VBG	denotes	including
T40224	66119-66127	JJ	denotes	cerebral
T40225	66128-66134	NN	denotes	cortex
T40226	66134-66136	,	denotes	,
T40227	66136-66145	NN	denotes	brainstem
T40228	66145-66147	,	denotes	,
T40229	66147-66150	CC	denotes	and
T40230	66151-66161	NN	denotes	cerebellum
T40231	66161-66163	,	denotes	,
T40232	66163-66167	VBD	denotes	were
T40233	66179-66181	IN	denotes	in
T40234	66182-66188	VBN	denotes	graded
T40235	66189-66203	NNS	denotes	concentrations
T40236	66204-66206	IN	denotes	of
T40237	66207-66214	NN	denotes	alcohol
T40238	66215-66218	CC	denotes	and
T40239	66219-66227	VBN	denotes	embedded
T40240	66228-66230	IN	denotes	in
T40241	66231-66239	NN	denotes	paraffin
T40242	66240-66244	IN	denotes	from
T40243	66270-66278	VBN	denotes	prepared
T40244	66245-66250	WDT	denotes	which
T40245	66251-66252	CD	denotes	5
T40246	66253-66255	NN	denotes	μm
T40247	66252-66253	HYPH	denotes	-
T40248	66256-66264	NNS	denotes	sections
T40249	66265-66269	VBD	denotes	were
T40250	66278-66279	.	denotes	.
T40760	66281-66288	JJ	denotes	Primary
T40761	66306-66313	NNS	denotes	studies
T40762	66289-66294	NN	denotes	mouse
T40763	66295-66305	NN	denotes	hepatocyte
T40764	66313-66435	sentence	denotes	Primary cultures of mouse hepatocytes were prepared from male PGC-1α+/+ and PGC-1α−/− mice essentially as described [47].
T40765	66314-66321	JJ	denotes	Primary
T40766	66322-66330	NNS	denotes	cultures
T40767	66357-66365	VBN	denotes	prepared
T40768	66331-66333	IN	denotes	of
T40769	66334-66339	NN	denotes	mouse
T40770	66340-66351	NNS	denotes	hepatocytes
T40771	66352-66356	VBD	denotes	were
T40772	66366-66370	IN	denotes	from
T40773	66371-66375	JJ	denotes	male
T40774	66400-66404	NNS	denotes	mice
T40775	66376-66379	NN	denotes	PGC
T40776	66380-66382	NN	denotes	1α
T40777	66379-66380	HYPH	denotes	-
T40778	66382-66383	SYM	denotes	+
T40779	66383-66384	HYPH	denotes	/
T40780	66384-66385	SYM	denotes	+
T40781	66386-66389	CC	denotes	and
T40782	66390-66393	NN	denotes	PGC
T40783	66394-66396	NN	denotes	1α
T40784	66393-66394	HYPH	denotes	-
T40785	66396-66397	SYM	denotes	−
T40786	66397-66398	HYPH	denotes	/
T40787	66398-66399	SYM	denotes	−
T40788	66405-66416	RB	denotes	essentially
T40789	66420-66429	VBN	denotes	described
T40790	66417-66419	IN	denotes	as
T40791	66430-66431	-LRB-	denotes	[
T40792	66431-66433	CD	denotes	47
T40793	66433-66434	-RRB-	denotes	]
T40794	66434-66435	.	denotes	.
T40795	66435-66545	sentence	denotes	Fatty acid oxidation and triglyceride synthesis experiments were commenced 2–3 h after the cells were plated.
T40796	66436-66441	JJ	denotes	Fatty
T40797	66442-66446	NN	denotes	acid
T40798	66447-66456	NN	denotes	oxidation
T40799	66484-66495	NNS	denotes	experiments
T40800	66457-66460	CC	denotes	and
T40801	66461-66473	NN	denotes	triglyceride
T40802	66474-66483	NN	denotes	synthesis
T40803	66501-66510	VBN	denotes	commenced
T40804	66496-66500	VBD	denotes	were
T40805	66511-66512	CD	denotes	2
T40806	66513-66514	CD	denotes	3
T40807	66512-66513	SYM	denotes	–
T40808	66515-66516	NN	denotes	h
T40809	66538-66544	VBN	denotes	plated
T40810	66517-66522	IN	denotes	after
T40811	66523-66526	DT	denotes	the
T40812	66527-66532	NNS	denotes	cells
T40813	66533-66537	VBD	denotes	were
T40814	66544-66545	.	denotes	.
T40815	66545-66622	sentence	denotes	Triglyceride synthesis studies, were performed as previously described [47].
T40816	66546-66558	NN	denotes	Triglyceride
T40817	66559-66568	NN	denotes	synthesis
T40818	66569-66576	NNS	denotes	studies
T40819	66583-66592	VBN	denotes	performed
T40820	66576-66578	,	denotes	,
T40821	66578-66582	VBD	denotes	were
T40822	66593-66595	IN	denotes	as
T40823	66607-66616	VBN	denotes	described
T40824	66596-66606	RB	denotes	previously
T40825	66617-66618	-LRB-	denotes	[
T40826	66618-66620	CD	denotes	47
T40827	66620-66621	-RRB-	denotes	]
T40828	66621-66622	.	denotes	.
T40829	66622-66762	sentence	denotes	Palmitate oxidation rates were quantified using [9,10-3H]-palmitic acid as described [48] and corrected for total cellular protein content.
T40830	66623-66632	NN	denotes	Palmitate
T40831	66643-66648	NNS	denotes	rates
T40832	66633-66642	NN	denotes	oxidation
T40833	66654-66664	VBN	denotes	quantified
T40834	66649-66653	VBD	denotes	were
T40835	66665-66670	VBG	denotes	using
T40836	66671-66672	-LRB-	denotes	[
T40837	66672-66673	CD	denotes	9
T40838	66677-66679	NN	denotes	3H
T40839	66673-66674	,	denotes	,
T40840	66674-66676	CD	denotes	10
T40841	66676-66677	SYM	denotes	-
T40842	66681-66689	JJ	denotes	palmitic
T40843	66679-66680	-RRB-	denotes	]
T40844	66680-66681	HYPH	denotes	-
T40845	66690-66694	NN	denotes	acid
T40846	66695-66697	IN	denotes	as
T40847	66698-66707	VBN	denotes	described
T40848	66708-66709	-LRB-	denotes	[
T40849	66709-66711	CD	denotes	48
T40850	66711-66712	-RRB-	denotes	]
T40851	66713-66716	CC	denotes	and
T40852	66717-66726	VBN	denotes	corrected
T40853	66727-66730	IN	denotes	for
T40854	66731-66736	JJ	denotes	total
T40855	66754-66761	NN	denotes	content
T40856	66737-66745	JJ	denotes	cellular
T40857	66746-66753	NN	denotes	protein
T40858	66761-66762	.	denotes	.
T40859	66762-66917	sentence	denotes	For respiration studies, cells were spun down prior to plating and resuspended in a permeabilization buffer (described above) containing 50 μg/ml saponin.
T40860	66763-66766	IN	denotes	For
T40861	66799-66803	VBN	denotes	spun
T40862	66767-66778	NN	denotes	respiration
T40863	66779-66786	NNS	denotes	studies
T40864	66786-66788	,	denotes	,
T40865	66788-66793	NNS	denotes	cells
T40866	66794-66798	VBD	denotes	were
T40867	66804-66808	RP	denotes	down
T40868	66809-66814	JJ	denotes	prior
T40869	66815-66817	IN	denotes	to
T40870	66818-66825	NN	denotes	plating
T40871	66826-66829	CC	denotes	and
T40872	66830-66841	VBN	denotes	resuspended
T40873	66842-66844	IN	denotes	in
T40874	66845-66846	DT	denotes	a
T40875	66864-66870	NN	denotes	buffer
T40876	66847-66863	NN	denotes	permeabilization
T40877	66871-66872	-LRB-	denotes	(
T40878	66872-66881	VBN	denotes	described
T40879	66882-66887	RB	denotes	above
T40880	66887-66888	-RRB-	denotes	)
T40881	66889-66899	VBG	denotes	containing
T40882	66900-66902	CD	denotes	50
T40883	66903-66905	NN	denotes	μg
T40884	66909-66916	NN	denotes	saponin
T40885	66905-66906	SYM	denotes	/
T40886	66906-66908	NN	denotes	ml
T40887	66916-66917	.	denotes	.
T40888	66917-67021	sentence	denotes	Respiration studies were performed in the presence of 5 mM succinate in the presence of 10 μM rotenone.
T40889	66918-66929	NN	denotes	Respiration
T40890	66930-66937	NNS	denotes	studies
T40891	66943-66952	VBN	denotes	performed
T40892	66938-66942	VBD	denotes	were
T40893	66953-66955	IN	denotes	in
T40894	66956-66959	DT	denotes	the
T40895	66960-66968	NN	denotes	presence
T40896	66969-66971	IN	denotes	of
T40897	66972-66973	CD	denotes	5
T40898	66974-66976	NN	denotes	mM
T40899	66977-66986	NN	denotes	succinate
T40900	66987-66989	IN	denotes	in
T40901	66990-66993	DT	denotes	the
T40902	66994-67002	NN	denotes	presence
T40903	67003-67005	IN	denotes	of
T40904	67006-67008	CD	denotes	10
T40905	67009-67011	NN	denotes	μM
T40906	67012-67020	NN	denotes	rotenone
T40907	67020-67021	.	denotes	.
T40908	67021-67092	sentence	denotes	Respiration rates were expressed as nmol O2 · min−1 · mg of protein−1.
T40909	67022-67033	NN	denotes	Respiration
T40910	67034-67039	NNS	denotes	rates
T40911	67045-67054	VBN	denotes	expressed
T40912	67040-67044	VBD	denotes	were
T40913	67055-67057	IN	denotes	as
T40914	67058-67062	NN	denotes	nmol
T40915	67063-67065	NN	denotes	O2
T40916	67066-67067	SYM	denotes	·
T40917	67068-67071	NN	denotes	min
T40918	67071-67072	SYM	denotes	−
T40919	67072-67073	CD	denotes	1
T40920	67074-67075	SYM	denotes	·
T40921	67076-67078	NN	denotes	mg
T40922	67079-67081	IN	denotes	of
T40923	67082-67089	NN	denotes	protein
T40924	67089-67090	SYM	denotes	−
T40925	67090-67091	CD	denotes	1
T40926	67091-67092	.	denotes	.
T42846	67094-67104	NN	denotes	Evaluation
T42847	67105-67107	IN	denotes	of
T42848	67108-67117	NN	denotes	locomotor
T42849	67118-67126	NN	denotes	activity
T42850	67126-67128	,	denotes	,
T42851	67128-67140	NN	denotes	sensorimotor
T42852	67141-67153	NNS	denotes	capabilities
T42853	67153-67155	,	denotes	,
T42854	67155-67158	CC	denotes	and
T42855	67159-67165	NN	denotes	muscle
T42856	67166-67174	NN	denotes	function
T42857	67174-67470	sentence	denotes	To evaluate general activity levels and muscle use, mice were evaluated over a 1-h period in transparent (47.6 cm × 25.4 cm × 20.6 cm) polystyrene enclosures as previously described [49] using a high-resolution photobeam system (Motor Monitor, Hamilton-Kinder, Poway, California, United States).
T42858	67175-67177	TO	denotes	To
T42859	67178-67186	VB	denotes	evaluate
T42860	67237-67246	VBN	denotes	evaluated
T42861	67187-67194	JJ	denotes	general
T42862	67204-67210	NNS	denotes	levels
T42863	67195-67203	NN	denotes	activity
T42864	67211-67214	CC	denotes	and
T42865	67215-67221	NN	denotes	muscle
T42866	67222-67225	NN	denotes	use
T42867	67225-67227	,	denotes	,
T42868	67227-67231	NNS	denotes	mice
T42869	67232-67236	VBD	denotes	were
T42870	67247-67251	IN	denotes	over
T42871	67252-67253	DT	denotes	a
T42872	67258-67264	NN	denotes	period
T42873	67254-67255	CD	denotes	1
T42874	67256-67257	NN	denotes	h
T42875	67255-67256	HYPH	denotes	-
T42876	67265-67267	IN	denotes	in
T42877	67268-67279	NN	denotes	transparent
T42878	67310-67321	NN	denotes	polystyrene
T42879	67280-67281	-LRB-	denotes	(
T42880	67281-67285	CD	denotes	47.6
T42881	67286-67288	NN	denotes	cm
T42882	67289-67290	SYM	denotes	×
T42883	67296-67298	NN	denotes	cm
T42884	67291-67295	CD	denotes	25.4
T42885	67299-67300	SYM	denotes	×
T42886	67306-67308	NN	denotes	cm
T42887	67301-67305	CD	denotes	20.6
T42888	67308-67309	-RRB-	denotes	)
T42889	67322-67332	VBZ	denotes	enclosures
T42890	67333-67335	IN	denotes	as
T42891	67347-67356	VBN	denotes	described
T42892	67336-67346	RB	denotes	previously
T42893	67357-67358	-LRB-	denotes	[
T42894	67358-67360	CD	denotes	49
T42895	67360-67361	-RRB-	denotes	]
T42896	67362-67367	VBG	denotes	using
T42897	67368-67369	DT	denotes	a
T42898	67396-67402	NN	denotes	system
T42899	67370-67374	JJ	denotes	high
T42900	67375-67385	NN	denotes	resolution
T42901	67374-67375	HYPH	denotes	-
T42902	67386-67395	NN	denotes	photobeam
T42903	67403-67404	-LRB-	denotes	(
T42904	67410-67417	NNP	denotes	Monitor
T42905	67404-67409	NNP	denotes	Motor
T42906	67417-67419	,	denotes	,
T42907	67419-67427	NNP	denotes	Hamilton
T42908	67428-67434	NNP	denotes	Kinder
T42909	67427-67428	HYPH	denotes	-
T42910	67434-67436	,	denotes	,
T42911	67436-67441	NNP	denotes	Poway
T42912	67441-67443	,	denotes	,
T42913	67443-67453	NNP	denotes	California
T42914	67453-67455	,	denotes	,
T42915	67455-67461	NNP	denotes	United
T42916	67462-67468	NNP	denotes	States
T42917	67468-67469	-RRB-	denotes	)
T42918	67469-67470	.	denotes	.
T42919	67470-67609	sentence	denotes	Each enclosure was surrounded by a frame containing a 4 × 8 matrix of photocell pairs, the output of which was fed to an on-line computer.
T42920	67471-67475	DT	denotes	Each
T42921	67476-67485	NN	denotes	enclosure
T42922	67490-67500	VBN	denotes	surrounded
T42923	67486-67489	VBD	denotes	was
T42924	67501-67503	IN	denotes	by
T42925	67504-67505	DT	denotes	a
T42926	67506-67511	NN	denotes	frame
T42927	67512-67522	VBG	denotes	containing
T42928	67523-67524	DT	denotes	a
T42929	67531-67537	NN	denotes	matrix
T42930	67525-67526	CD	denotes	4
T42931	67527-67528	SYM	denotes	×
T42932	67529-67530	CD	denotes	8
T42933	67538-67540	IN	denotes	of
T42934	67541-67550	NN	denotes	photocell
T42935	67551-67556	NNS	denotes	pairs
T42936	67556-67558	,	denotes	,
T42937	67558-67561	DT	denotes	the
T42938	67562-67568	NN	denotes	output
T42939	67582-67585	VBN	denotes	fed
T42940	67569-67571	IN	denotes	of
T42941	67572-67577	WDT	denotes	which
T42942	67578-67581	VBD	denotes	was
T42943	67586-67588	IN	denotes	to
T42944	67589-67591	DT	denotes	an
T42945	67600-67608	NN	denotes	computer
T42946	67592-67594	IN	denotes	on
T42947	67594-67595	HYPH	denotes	-
T42948	67595-67599	NN	denotes	line
T42949	67608-67609	.	denotes	.
T42950	67609-67810	sentence	denotes	The system software (Hamilton-Kinder) was used to define a 33 cm × 11 cm central zone and a peripheral or surrounding zone that was 5.5 cm wide with the sides of the cage being the outermost boundary.
T42951	67610-67613	DT	denotes	The
T42952	67621-67629	NN	denotes	software
T42953	67614-67620	NN	denotes	system
T42954	67652-67656	VBN	denotes	used
T42955	67630-67631	-LRB-	denotes	(
T42956	67640-67646	NNP	denotes	Kinder
T42957	67631-67639	NNP	denotes	Hamilton
T42958	67639-67640	HYPH	denotes	-
T42959	67646-67647	-RRB-	denotes	)
T42960	67648-67651	VBD	denotes	was
T42961	67657-67659	TO	denotes	to
T42962	67660-67666	VB	denotes	define
T42963	67667-67668	DT	denotes	a
T42964	67691-67695	NN	denotes	zone
T42965	67669-67671	CD	denotes	33
T42966	67672-67674	NN	denotes	cm
T42967	67675-67676	SYM	denotes	×
T42968	67680-67682	NN	denotes	cm
T42969	67677-67679	CD	denotes	11
T42970	67683-67690	JJ	denotes	central
T42971	67696-67699	CC	denotes	and
T42972	67700-67701	DT	denotes	a
T42973	67728-67732	NN	denotes	zone
T42974	67702-67712	JJ	denotes	peripheral
T42975	67713-67715	CC	denotes	or
T42976	67716-67727	VBG	denotes	surrounding
T42977	67733-67737	WDT	denotes	that
T42978	67738-67741	VBD	denotes	was
T42979	67742-67745	CD	denotes	5.5
T42980	67746-67748	NN	denotes	cm
T42981	67749-67753	JJ	denotes	wide
T42982	67754-67758	IN	denotes	with
T42983	67759-67762	DT	denotes	the
T42984	67763-67768	NNS	denotes	sides
T42985	67781-67786	VBG	denotes	being
T42986	67769-67771	IN	denotes	of
T42987	67772-67775	DT	denotes	the
T42988	67776-67780	NN	denotes	cage
T42989	67787-67790	DT	denotes	the
T42990	67801-67809	NN	denotes	boundary
T42991	67791-67800	JJ	denotes	outermost
T42992	67809-67810	.	denotes	.
T42993	67810-67880	sentence	denotes	This peripheral area extended along the entire perimeter of the cage.
T42994	67811-67815	DT	denotes	This
T42995	67827-67831	NN	denotes	area
T42996	67816-67826	JJ	denotes	peripheral
T42997	67832-67840	VBD	denotes	extended
T42998	67841-67846	IN	denotes	along
T42999	67847-67850	DT	denotes	the
T43000	67858-67867	NN	denotes	perimeter
T43001	67851-67857	JJ	denotes	entire
T43002	67868-67870	IN	denotes	of
T43003	67871-67874	DT	denotes	the
T43004	67875-67879	NN	denotes	cage
T43005	67879-67880	.	denotes	.
T43006	67880-68120	sentence	denotes	Variables that were analyzed included the total number of ambulations, as well as the number of entries, the time spent, and the distance traveled in the center area as well as the distance traveled in the periphery surrounding the center.
T43007	67881-67890	NNS	denotes	Variables
T43008	67910-67918	VBD	denotes	included
T43009	67891-67895	WDT	denotes	that
T43010	67901-67909	VBN	denotes	analyzed
T43011	67896-67900	VBD	denotes	were
T43012	67919-67922	DT	denotes	the
T43013	67929-67935	NN	denotes	number
T43014	67923-67928	JJ	denotes	total
T43015	67936-67938	IN	denotes	of
T43016	67939-67950	NNS	denotes	ambulations
T43017	67950-67952	,	denotes	,
T43018	67952-67954	RB	denotes	as
T43019	67960-67962	IN	denotes	as
T43020	67955-67959	RB	denotes	well
T43021	67963-67966	DT	denotes	the
T43022	67967-67973	NN	denotes	number
T43023	67974-67976	IN	denotes	of
T43024	67977-67984	NNS	denotes	entries
T43025	67984-67986	,	denotes	,
T43026	67986-67989	DT	denotes	the
T43027	67990-67994	NN	denotes	time
T43028	67995-68000	VBN	denotes	spent
T43029	68000-68002	,	denotes	,
T43030	68002-68005	CC	denotes	and
T43031	68006-68009	DT	denotes	the
T43032	68010-68018	NN	denotes	distance
T43033	68019-68027	VBN	denotes	traveled
T43034	68028-68030	IN	denotes	in
T43035	68031-68034	DT	denotes	the
T43036	68042-68046	NN	denotes	area
T43037	68035-68041	NN	denotes	center
T43038	68047-68049	RB	denotes	as
T43039	68055-68057	IN	denotes	as
T43040	68050-68054	RB	denotes	well
T43041	68058-68061	DT	denotes	the
T43042	68062-68070	NN	denotes	distance
T43043	68071-68079	VBN	denotes	traveled
T43044	68080-68082	IN	denotes	in
T43045	68083-68086	DT	denotes	the
T43046	68087-68096	NN	denotes	periphery
T43047	68097-68108	VBG	denotes	surrounding
T43048	68109-68112	DT	denotes	the
T43049	68113-68119	NN	denotes	center
T43050	68119-68120	.	denotes	.
T43051	68120-68180	sentence	denotes	The total number of ambulations and rearings were recorded.
T43052	68121-68124	DT	denotes	The
T43053	68131-68137	NN	denotes	number
T43054	68125-68130	JJ	denotes	total
T43055	68171-68179	VBN	denotes	recorded
T43056	68138-68140	IN	denotes	of
T43057	68141-68152	NNS	denotes	ambulations
T43058	68153-68156	CC	denotes	and
T43059	68157-68165	NNS	denotes	rearings
T43060	68166-68170	VBD	denotes	were
T43061	68179-68180	.	denotes	.
T43062	68180-68307	sentence	denotes	For the inverted screen test, mice were placed on a wire mesh grid (16 squares per 10 cm) and the screen was inverted to 180°.
T43063	68181-68184	IN	denotes	For
T43064	68221-68227	VBN	denotes	placed
T43065	68185-68188	DT	denotes	the
T43066	68205-68209	NN	denotes	test
T43067	68189-68197	VBN	denotes	inverted
T43068	68198-68204	NN	denotes	screen
T43069	68209-68211	,	denotes	,
T43070	68211-68215	NNS	denotes	mice
T43071	68216-68220	VBD	denotes	were
T43072	68228-68230	IN	denotes	on
T43073	68231-68232	DT	denotes	a
T43074	68243-68247	NN	denotes	grid
T43075	68233-68237	NN	denotes	wire
T43076	68238-68242	NN	denotes	mesh
T43077	68248-68249	-LRB-	denotes	(
T43078	68252-68259	NNS	denotes	squares
T43079	68249-68251	CD	denotes	16
T43080	68260-68263	IN	denotes	per
T43081	68264-68266	CD	denotes	10
T43082	68267-68269	NN	denotes	cm
T43083	68269-68270	-RRB-	denotes	)
T43084	68271-68274	CC	denotes	and
T43085	68275-68278	DT	denotes	the
T43086	68279-68285	NN	denotes	screen
T43087	68290-68298	VBN	denotes	inverted
T43088	68286-68289	VBD	denotes	was
T43089	68299-68301	IN	denotes	to
T43090	68302-68305	CD	denotes	180
T43091	68305-68306	NN	denotes	°
T43092	68306-68307	.	denotes	.
T43093	68307-68368	sentence	denotes	A maximum score of 60 s was given if an animal did not fall.
T43094	68308-68309	DT	denotes	A
T43095	68318-68323	NN	denotes	score
T43096	68310-68317	JJ	denotes	maximum
T43097	68336-68341	VBN	denotes	given
T43098	68324-68326	IN	denotes	of
T43099	68327-68329	CD	denotes	60
T43100	68330-68331	NN	denotes	s
T43101	68332-68335	VBD	denotes	was
T43102	68342-68344	IN	denotes	if
T43103	68363-68367	VB	denotes	fall
T43104	68345-68347	DT	denotes	an
T43105	68348-68354	NN	denotes	animal
T43106	68355-68358	VBD	denotes	did
T43107	68359-68362	RB	denotes	not
T43108	68367-68368	.	denotes	.
T43109	68368-68473	sentence	denotes	The tests included in the sensorimotor battery [50] and accompanying protocols were designed as follows.
T43110	68369-68372	DT	denotes	The
T43111	68373-68378	NNS	denotes	tests
T43112	68453-68461	VBN	denotes	designed
T43113	68379-68387	VBN	denotes	included
T43114	68388-68390	IN	denotes	in
T43115	68391-68394	DT	denotes	the
T43116	68408-68415	NN	denotes	battery
T43117	68395-68407	NN	denotes	sensorimotor
T43118	68416-68417	-LRB-	denotes	[
T43119	68417-68419	CD	denotes	50
T43120	68419-68420	-RRB-	denotes	]
T43121	68421-68424	CC	denotes	and
T43122	68425-68437	VBG	denotes	accompanying
T43123	68438-68447	NNS	denotes	protocols
T43124	68448-68452	VBD	denotes	were
T43125	68462-68464	IN	denotes	as
T43126	68465-68472	VBZ	denotes	follows
T43127	68472-68473	.	denotes	.
T43128	68473-68690	sentence	denotes	(1) Inclined screen and inverted screen tests: For the inclined screen tests, each mouse was placed on top of an elevated (47 cm above the floor) wire mesh grid (16 squares per 10 cm) that was inclined to 60° or 90°.
T43129	68474-68475	-LRB-	denotes	(
T43130	68475-68476	LS	denotes	1
T43131	68567-68573	VBN	denotes	placed
T43132	68476-68477	-RRB-	denotes	)
T43133	68478-68486	VBN	denotes	Inclined
T43134	68487-68493	NN	denotes	screen
T43135	68514-68519	NNS	denotes	tests
T43136	68494-68497	CC	denotes	and
T43137	68498-68506	VBN	denotes	inverted
T43138	68507-68513	NN	denotes	screen
T43139	68519-68521	:	denotes	:
T43140	68521-68524	IN	denotes	For
T43141	68525-68528	DT	denotes	the
T43142	68545-68550	NNS	denotes	tests
T43143	68529-68537	VBN	denotes	inclined
T43144	68538-68544	NN	denotes	screen
T43145	68550-68552	,	denotes	,
T43146	68552-68556	DT	denotes	each
T43147	68557-68562	NN	denotes	mouse
T43148	68563-68566	VBD	denotes	was
T43149	68574-68576	IN	denotes	on
T43150	68577-68580	NN	denotes	top
T43151	68581-68583	IN	denotes	of
T43152	68584-68586	DT	denotes	an
T43153	68630-68634	NN	denotes	grid
T43154	68587-68595	JJ	denotes	elevated
T43155	68596-68597	-LRB-	denotes	(
T43156	68603-68608	IN	denotes	above
T43157	68597-68599	CD	denotes	47
T43158	68600-68602	NN	denotes	cm
T43159	68609-68612	DT	denotes	the
T43160	68613-68618	NN	denotes	floor
T43161	68618-68619	-RRB-	denotes	)
T43162	68620-68624	NN	denotes	wire
T43163	68625-68629	NN	denotes	mesh
T43164	68635-68636	-LRB-	denotes	(
T43165	68639-68646	NNS	denotes	squares
T43166	68636-68638	CD	denotes	16
T43167	68647-68650	IN	denotes	per
T43168	68651-68653	CD	denotes	10
T43169	68654-68656	NN	denotes	cm
T43170	68656-68657	-RRB-	denotes	)
T43171	68658-68662	WDT	denotes	that
T43172	68667-68675	VBN	denotes	inclined
T43173	68663-68666	VBD	denotes	was
T43174	68676-68678	IN	denotes	to
T43175	68679-68681	CD	denotes	60
T43176	68681-68682	NN	denotes	°
T43177	68683-68685	CC	denotes	or
T43178	68686-68688	CD	denotes	90
T43179	68688-68689	NN	denotes	°
T43180	68689-68690	.	denotes	.
T43181	68690-68878	sentence	denotes	Each animal was placed in the middle of the screen with its head oriented down and was timed for how long it remained on the screen and how long it took to climb to the top of the screen.
T43182	68691-68695	DT	denotes	Each
T43183	68696-68702	NN	denotes	animal
T43184	68707-68713	VBN	denotes	placed
T43185	68703-68706	VBD	denotes	was
T43186	68714-68716	IN	denotes	in
T43187	68717-68720	DT	denotes	the
T43188	68721-68727	NN	denotes	middle
T43189	68728-68730	IN	denotes	of
T43190	68731-68734	DT	denotes	the
T43191	68735-68741	NN	denotes	screen
T43192	68742-68746	IN	denotes	with
T43193	68756-68764	VBN	denotes	oriented
T43194	68747-68750	PRP$	denotes	its
T43195	68751-68755	NN	denotes	head
T43196	68765-68769	RB	denotes	down
T43197	68770-68773	CC	denotes	and
T43198	68774-68777	VBD	denotes	was
T43199	68778-68783	VBN	denotes	timed
T43200	68784-68787	IN	denotes	for
T43201	68788-68791	WRB	denotes	how
T43202	68792-68796	RB	denotes	long
T43203	68800-68808	VBD	denotes	remained
T43204	68797-68799	PRP	denotes	it
T43205	68809-68811	IN	denotes	on
T43206	68812-68815	DT	denotes	the
T43207	68816-68822	NN	denotes	screen
T43208	68823-68826	CC	denotes	and
T43209	68827-68830	WRB	denotes	how
T43210	68831-68835	RB	denotes	long
T43211	68839-68843	VBD	denotes	took
T43212	68836-68838	PRP	denotes	it
T43213	68844-68846	TO	denotes	to
T43214	68847-68852	VB	denotes	climb
T43215	68853-68855	IN	denotes	to
T43216	68856-68859	DT	denotes	the
T43217	68860-68863	NN	denotes	top
T43218	68864-68866	IN	denotes	of
T43219	68867-68870	DT	denotes	the
T43220	68871-68877	NN	denotes	screen
T43221	68877-68878	.	denotes	.
T43222	68878-68976	sentence	denotes	For the inverted screen test, mice were placed as above and then the screen was inverted to 180°.
T43223	68879-68882	IN	denotes	For
T43224	68919-68925	VBN	denotes	placed
T43225	68883-68886	DT	denotes	the
T43226	68903-68907	NN	denotes	test
T43227	68887-68895	VBN	denotes	inverted
T43228	68896-68902	NN	denotes	screen
T43229	68907-68909	,	denotes	,
T43230	68909-68913	NNS	denotes	mice
T43231	68914-68918	VBD	denotes	were
T43232	68926-68928	IN	denotes	as
T43233	68929-68934	RB	denotes	above
T43234	68935-68938	CC	denotes	and
T43235	68939-68943	RB	denotes	then
T43236	68959-68967	VBN	denotes	inverted
T43237	68944-68947	DT	denotes	the
T43238	68948-68954	NN	denotes	screen
T43239	68955-68958	VBD	denotes	was
T43240	68968-68970	IN	denotes	to
T43241	68971-68974	CD	denotes	180
T43242	68974-68975	NN	denotes	°
T43243	68975-68976	.	denotes	.
T43244	68976-69037	sentence	denotes	A maximum score of 60 s was given if an animal did not fall;
T43245	68977-68978	DT	denotes	A
T43246	68987-68992	NN	denotes	score
T43247	68979-68986	JJ	denotes	maximum
T43248	69005-69010	VBN	denotes	given
T43249	68993-68995	IN	denotes	of
T43250	68996-68998	CD	denotes	60
T43251	68999-69000	NN	denotes	s
T43252	69001-69004	VBD	denotes	was
T43253	69011-69013	IN	denotes	if
T43254	69032-69036	VB	denotes	fall
T43255	69014-69016	DT	denotes	an
T43256	69017-69023	NN	denotes	animal
T43257	69024-69027	VBD	denotes	did
T43258	69028-69031	RB	denotes	not
T43259	69036-69037	:	denotes	;
T43260	69037-69198	sentence	denotes	(2) Platform test: Each mouse was timed for how long it remained on an elevated (47 cm above the floor) circular platform (1.0 cm thick and 3.0 cm in diameter).
T43261	69038-69039	-LRB-	denotes	(
T43262	69039-69040	LS	denotes	2
T43263	69072-69077	VBN	denotes	timed
T43264	69040-69041	-RRB-	denotes	)
T43265	69042-69050	NN	denotes	Platform
T43266	69051-69055	NN	denotes	test
T43267	69055-69057	:	denotes	:
T43268	69057-69061	DT	denotes	Each
T43269	69062-69067	NN	denotes	mouse
T43270	69068-69071	VBD	denotes	was
T43271	69078-69081	IN	denotes	for
T43272	69082-69085	WRB	denotes	how
T43273	69086-69090	RB	denotes	long
T43274	69094-69102	VBD	denotes	remained
T43275	69091-69093	PRP	denotes	it
T43276	69103-69105	IN	denotes	on
T43277	69106-69108	DT	denotes	an
T43278	69151-69159	NN	denotes	platform
T43279	69109-69117	JJ	denotes	elevated
T43280	69118-69119	-LRB-	denotes	(
T43281	69125-69130	IN	denotes	above
T43282	69119-69121	CD	denotes	47
T43283	69122-69124	NN	denotes	cm
T43284	69131-69134	DT	denotes	the
T43285	69135-69140	NN	denotes	floor
T43286	69140-69141	-RRB-	denotes	)
T43287	69142-69150	JJ	denotes	circular
T43288	69160-69161	-LRB-	denotes	(
T43289	69168-69173	JJ	denotes	thick
T43290	69161-69164	CD	denotes	1.0
T43291	69165-69167	NN	denotes	cm
T43292	69174-69177	CC	denotes	and
T43293	69178-69181	CD	denotes	3.0
T43294	69182-69184	NN	denotes	cm
T43295	69185-69187	IN	denotes	in
T43296	69188-69196	NN	denotes	diameter
T43297	69196-69197	-RRB-	denotes	)
T43298	69197-69198	.	denotes	.
T43299	69198-69396	sentence	denotes	A maximum score of 60 s was assigned if the mouse remained on the platform for the maximum amount of time or if it could climb down on a very thin pole that supported the platform, without falling;
T43300	69199-69200	DT	denotes	A
T43301	69209-69214	NN	denotes	score
T43302	69201-69208	JJ	denotes	maximum
T43303	69227-69235	VBN	denotes	assigned
T43304	69215-69217	IN	denotes	of
T43305	69218-69220	CD	denotes	60
T43306	69221-69222	NN	denotes	s
T43307	69223-69226	VBD	denotes	was
T43308	69236-69238	IN	denotes	if
T43309	69249-69257	VBD	denotes	remained
T43310	69239-69242	DT	denotes	the
T43311	69243-69248	NN	denotes	mouse
T43312	69258-69260	IN	denotes	on
T43313	69261-69264	DT	denotes	the
T43314	69265-69273	NN	denotes	platform
T43315	69274-69277	IN	denotes	for
T43316	69278-69281	DT	denotes	the
T43317	69290-69296	NN	denotes	amount
T43318	69282-69289	NN	denotes	maximum
T43319	69297-69299	IN	denotes	of
T43320	69300-69304	NN	denotes	time
T43321	69305-69307	CC	denotes	or
T43322	69308-69310	IN	denotes	if
T43323	69320-69325	VB	denotes	climb
T43324	69311-69313	PRP	denotes	it
T43325	69314-69319	MD	denotes	could
T43326	69326-69330	RB	denotes	down
T43327	69331-69333	IN	denotes	on
T43328	69334-69335	DT	denotes	a
T43329	69346-69350	NN	denotes	pole
T43330	69336-69340	RB	denotes	very
T43331	69341-69345	JJ	denotes	thin
T43332	69351-69355	WDT	denotes	that
T43333	69356-69365	VBD	denotes	supported
T43334	69366-69369	DT	denotes	the
T43335	69370-69378	NN	denotes	platform
T43336	69378-69380	,	denotes	,
T43337	69380-69387	IN	denotes	without
T43338	69388-69395	VBG	denotes	falling
T43339	69395-69396	:	denotes	;
T43340	69396-69542	sentence	denotes	(3) Ledge test: Each mouse was timed for how long it could maintain its balance on a 0.75-cm wide Plexiglas ledge without falling (60 s maximum).
T43341	69397-69398	-LRB-	denotes	(
T43342	69398-69399	LS	denotes	3
T43343	69428-69433	VBN	denotes	timed
T43344	69399-69400	-RRB-	denotes	)
T43345	69401-69406	NN	denotes	Ledge
T43346	69407-69411	NN	denotes	test
T43347	69411-69413	:	denotes	:
T43348	69413-69417	DT	denotes	Each
T43349	69418-69423	NN	denotes	mouse
T43350	69424-69427	VBD	denotes	was
T43351	69434-69437	IN	denotes	for
T43352	69438-69441	WRB	denotes	how
T43353	69442-69446	RB	denotes	long
T43354	69456-69464	VB	denotes	maintain
T43355	69447-69449	PRP	denotes	it
T43356	69450-69455	MD	denotes	could
T43357	69465-69468	PRP$	denotes	its
T43358	69469-69476	NN	denotes	balance
T43359	69477-69479	IN	denotes	on
T43360	69480-69481	DT	denotes	a
T43361	69505-69510	NN	denotes	ledge
T43362	69482-69486	CD	denotes	0.75
T43363	69487-69489	NN	denotes	cm
T43364	69486-69487	HYPH	denotes	-
T43365	69490-69494	JJ	denotes	wide
T43366	69495-69504	NN	denotes	Plexiglas
T43367	69511-69518	IN	denotes	without
T43368	69519-69526	VBG	denotes	falling
T43369	69527-69528	-LRB-	denotes	(
T43370	69533-69540	NN	denotes	maximum
T43371	69528-69530	CD	denotes	60
T43372	69531-69532	NN	denotes	s
T43373	69540-69541	-RRB-	denotes	)
T43374	69541-69542	.	denotes	.
T43375	69542-69718	sentence	denotes	A score of 60 s was also assigned if the mouse traversed the entire length (51 cm) of the Plexiglas ledge and returned to the starting place in less than 60 s without falling;
T43376	69543-69544	DT	denotes	A
T43377	69545-69550	NN	denotes	score
T43378	69568-69576	VBN	denotes	assigned
T43379	69551-69553	IN	denotes	of
T43380	69554-69556	CD	denotes	60
T43381	69557-69558	NN	denotes	s
T43382	69559-69562	VBD	denotes	was
T43383	69563-69567	RB	denotes	also
T43384	69577-69579	IN	denotes	if
T43385	69590-69599	VBD	denotes	traversed
T43386	69580-69583	DT	denotes	the
T43387	69584-69589	NN	denotes	mouse
T43388	69600-69603	DT	denotes	the
T43389	69611-69617	NN	denotes	length
T43390	69604-69610	JJ	denotes	entire
T43391	69618-69619	-LRB-	denotes	(
T43392	69619-69621	CD	denotes	51
T43393	69622-69624	NN	denotes	cm
T43394	69624-69625	-RRB-	denotes	)
T43395	69626-69628	IN	denotes	of
T43396	69629-69632	DT	denotes	the
T43397	69643-69648	NN	denotes	ledge
T43398	69633-69642	NN	denotes	Plexiglas
T43399	69649-69652	CC	denotes	and
T43400	69653-69661	VBD	denotes	returned
T43401	69662-69664	IN	denotes	to
T43402	69665-69668	DT	denotes	the
T43403	69678-69683	NN	denotes	place
T43404	69669-69677	NN	denotes	starting
T43405	69684-69686	IN	denotes	in
T43406	69687-69691	JJR	denotes	less
T43407	69697-69699	CD	denotes	60
T43408	69692-69696	IN	denotes	than
T43409	69700-69701	NN	denotes	s
T43410	69702-69709	IN	denotes	without
T43411	69710-69717	VBG	denotes	falling
T43412	69717-69718	:	denotes	;
T43413	69718-69887	sentence	denotes	(4) Walking initiation test: Each mouse was placed in the middle of a square outlined by white cloth tape (21 cm × 21 cm) on a smooth black surface of a large tabletop.
T43414	69719-69720	-LRB-	denotes	(
T43415	69720-69721	LS	denotes	4
T43416	69742-69746	NN	denotes	test
T43417	69721-69722	-RRB-	denotes	)
T43418	69723-69730	NN	denotes	Walking
T43419	69731-69741	NN	denotes	initiation
T43420	69746-69748	:	denotes	:
T43421	69748-69752	DT	denotes	Each
T43422	69753-69758	NN	denotes	mouse
T43423	69763-69769	VBN	denotes	placed
T43424	69759-69762	VBD	denotes	was
T43425	69770-69772	IN	denotes	in
T43426	69773-69776	DT	denotes	the
T43427	69777-69783	NN	denotes	middle
T43428	69784-69786	IN	denotes	of
T43429	69787-69788	DT	denotes	a
T43430	69789-69795	NN	denotes	square
T43431	69796-69804	VBN	denotes	outlined
T43432	69805-69807	IN	denotes	by
T43433	69808-69813	JJ	denotes	white
T43434	69820-69824	NN	denotes	tape
T43435	69814-69819	NN	denotes	cloth
T43436	69825-69826	-LRB-	denotes	(
T43437	69829-69831	NN	denotes	cm
T43438	69826-69828	CD	denotes	21
T43439	69832-69833	SYM	denotes	×
T43440	69837-69839	NN	denotes	cm
T43441	69834-69836	CD	denotes	21
T43442	69839-69840	-RRB-	denotes	)
T43443	69841-69843	IN	denotes	on
T43444	69844-69845	DT	denotes	a
T43445	69859-69866	NN	denotes	surface
T43446	69846-69852	JJ	denotes	smooth
T43447	69853-69858	JJ	denotes	black
T43448	69867-69869	IN	denotes	of
T43449	69870-69871	DT	denotes	a
T43450	69878-69886	NN	denotes	tabletop
T43451	69872-69877	JJ	denotes	large
T43452	69886-69887	CC	denotes	.
T43453	69887-69991	sentence	denotes	The time it took each mouse to leave the square (place all four paws outside of the tape) was recorded.
T43454	69888-69891	DT	denotes	The
T43455	69892-69896	NN	denotes	time
T43456	69982-69990	VBN	denotes	recorded
T43457	69897-69899	PRP	denotes	it
T43458	69900-69904	VBD	denotes	took
T43459	69905-69909	DT	denotes	each
T43460	69910-69915	NN	denotes	mouse
T43461	69919-69924	VB	denotes	leave
T43462	69916-69918	TO	denotes	to
T43463	69925-69928	DT	denotes	the
T43464	69929-69935	NN	denotes	square
T43465	69936-69937	-LRB-	denotes	(
T43466	69937-69942	VB	denotes	place
T43467	69943-69946	DT	denotes	all
T43468	69952-69956	NNS	denotes	paws
T43469	69947-69951	CD	denotes	four
T43470	69957-69964	RB	denotes	outside
T43471	69965-69967	IN	denotes	of
T43472	69968-69971	DT	denotes	the
T43473	69972-69976	NN	denotes	tape
T43474	69976-69977	-RRB-	denotes	)
T43475	69978-69981	VBD	denotes	was
T43476	69990-69991	.	denotes	.
T43477	69991-70026	sentence	denotes	The maximum time allowed was 60 s.
T43478	69992-69995	DT	denotes	The
T43479	70004-70008	NN	denotes	time
T43480	69996-70003	JJ	denotes	maximum
T43481	70017-70020	VBD	denotes	was
T43482	70009-70016	VBN	denotes	allowed
T43483	70021-70023	CD	denotes	60
T43484	70024-70025	NN	denotes	s
T43485	70025-70026	.	denotes	.
T43486	70026-70195	sentence	denotes	6–8-mo-old PGC-1α+/+ (n = 4) and PGC-1α−/− (n = 8) mice were run to exhaustion employing a motorized, speed controlled, modular treadmill system (Columbus Instruments).
T43487	70027-70028	CD	denotes	6
T43488	70029-70030	CD	denotes	8
T43489	70028-70029	SYM	denotes	–
T43490	70031-70033	NN	denotes	mo
T43491	70030-70031	HYPH	denotes	-
T43492	70034-70037	JJ	denotes	old
T43493	70033-70034	HYPH	denotes	-
T43494	70078-70082	NNS	denotes	mice
T43495	70038-70041	NN	denotes	PGC
T43496	70042-70044	NN	denotes	1α
T43497	70041-70042	HYPH	denotes	-
T43498	70044-70045	SYM	denotes	+
T43499	70045-70046	HYPH	denotes	/
T43500	70046-70047	SYM	denotes	+
T43501	70048-70049	-LRB-	denotes	(
T43502	70053-70054	CD	denotes	4
T43503	70049-70050	NN	denotes	n
T43504	70051-70052	SYM	denotes	=
T43505	70054-70055	-RRB-	denotes	)
T43506	70056-70059	CC	denotes	and
T43507	70060-70063	NN	denotes	PGC
T43508	70064-70066	NN	denotes	1α
T43509	70063-70064	HYPH	denotes	-
T43510	70066-70067	SYM	denotes	−
T43511	70067-70068	HYPH	denotes	/
T43512	70068-70069	SYM	denotes	−
T43513	70070-70071	-LRB-	denotes	(
T43514	70075-70076	CD	denotes	8
T43515	70071-70072	NN	denotes	n
T43516	70073-70074	SYM	denotes	=
T43517	70076-70077	-RRB-	denotes	)
T43518	70088-70091	VBN	denotes	run
T43519	70083-70087	VBD	denotes	were
T43520	70092-70094	IN	denotes	to
T43521	70095-70105	NN	denotes	exhaustion
T43522	70106-70115	VBG	denotes	employing
T43523	70116-70117	DT	denotes	a
T43524	70165-70171	NN	denotes	system
T43525	70118-70127	VBN	denotes	motorized
T43526	70127-70129	,	denotes	,
T43527	70129-70134	NN	denotes	speed
T43528	70135-70145	VBN	denotes	controlled
T43529	70145-70147	,	denotes	,
T43530	70147-70154	JJ	denotes	modular
T43531	70155-70164	NN	denotes	treadmill
T43532	70172-70173	-LRB-	denotes	(
T43533	70182-70193	NNP	denotes	Instruments
T43534	70173-70181	NNP	denotes	Columbus
T43535	70193-70194	-RRB-	denotes	)
T43536	70194-70195	.	denotes	.
T43537	70195-70291	sentence	denotes	The treadmill was equipped with an electric shock stimulus and an adjustable inclination angle.
T43538	70196-70199	DT	denotes	The
T43539	70200-70209	NN	denotes	treadmill
T43540	70214-70222	VBN	denotes	equipped
T43541	70210-70213	VBD	denotes	was
T43542	70223-70227	IN	denotes	with
T43543	70228-70230	DT	denotes	an
T43544	70246-70254	NN	denotes	stimulus
T43545	70231-70239	JJ	denotes	electric
T43546	70240-70245	NN	denotes	shock
T43547	70255-70258	CC	denotes	and
T43548	70259-70261	DT	denotes	an
T43549	70285-70290	NN	denotes	angle
T43550	70262-70272	JJ	denotes	adjustable
T43551	70273-70284	NN	denotes	inclination
T43552	70290-70291	.	denotes	.
T43553	70291-70361	sentence	denotes	Running velocity was set at 35 m/min, with a level inclination angle.
T43554	70292-70299	NN	denotes	Running
T43555	70300-70308	NN	denotes	velocity
T43556	70313-70316	VBN	denotes	set
T43557	70309-70312	VBD	denotes	was
T43558	70317-70319	IN	denotes	at
T43559	70320-70322	CD	denotes	35
T43560	70323-70324	NN	denotes	m
T43561	70324-70325	SYM	denotes	/
T43562	70325-70328	NN	denotes	min
T43563	70328-70330	,	denotes	,
T43564	70330-70334	IN	denotes	with
T43565	70335-70336	DT	denotes	a
T43566	70355-70360	NN	denotes	angle
T43567	70337-70342	NN	denotes	level
T43568	70343-70354	NN	denotes	inclination
T43569	70360-70361	.	denotes	.
T44022	70363-70369	NN	denotes	VO2max
T44023	70370-70377	NNS	denotes	studies
T44024	70377-70506	sentence	denotes	VO2max was determined while the mice were running on a treadmill using an open flow system (Columbus Instruments Oxymax System).
T44025	70378-70384	NN	denotes	VO2max
T44026	70389-70399	VBN	denotes	determined
T44027	70385-70388	VBD	denotes	was
T44028	70400-70405	IN	denotes	while
T44029	70420-70427	VBG	denotes	running
T44030	70406-70409	DT	denotes	the
T44031	70410-70414	NNS	denotes	mice
T44032	70415-70419	VBD	denotes	were
T44033	70428-70430	IN	denotes	on
T44034	70431-70432	DT	denotes	a
T44035	70433-70442	NN	denotes	treadmill
T44036	70443-70448	VBG	denotes	using
T44037	70449-70451	DT	denotes	an
T44038	70462-70468	NN	denotes	system
T44039	70452-70456	JJ	denotes	open
T44040	70457-70461	NN	denotes	flow
T44041	70469-70470	-LRB-	denotes	(
T44042	70498-70504	NNP	denotes	System
T44043	70470-70478	NNP	denotes	Columbus
T44044	70479-70490	NNP	denotes	Instruments
T44045	70491-70497	NNP	denotes	Oxymax
T44046	70504-70505	-RRB-	denotes	)
T44047	70505-70506	.	denotes	.
T44048	70506-70608	sentence	denotes	All measurements of oxygen consumption took place at an elevation of 150 m (ambient PBAR = 745 torr).
T44049	70507-70510	DT	denotes	All
T44050	70511-70523	NNS	denotes	measurements
T44051	70546-70550	VBD	denotes	took
T44052	70524-70526	IN	denotes	of
T44053	70527-70533	NN	denotes	oxygen
T44054	70534-70545	NN	denotes	consumption
T44055	70551-70556	NN	denotes	place
T44056	70557-70559	IN	denotes	at
T44057	70560-70562	DT	denotes	an
T44058	70563-70572	NN	denotes	elevation
T44059	70573-70575	IN	denotes	of
T44060	70576-70579	CD	denotes	150
T44061	70580-70581	NN	denotes	m
T44062	70582-70583	-LRB-	denotes	(
T44063	70602-70606	NN	denotes	torr
T44064	70583-70590	NN	denotes	ambient
T44065	70591-70595	NN	denotes	PBAR
T44066	70596-70597	SYM	denotes	=
T44067	70598-70601	CD	denotes	745
T44068	70606-70607	-RRB-	denotes	)
T44069	70607-70608	.	denotes	.
T44070	70608-70703	sentence	denotes	Animals were placed into the metabolic chamber for 3–5 min to allow the system to equilibrate.
T44071	70609-70616	NNS	denotes	Animals
T44072	70622-70628	VBN	denotes	placed
T44073	70617-70621	VBD	denotes	were
T44074	70629-70633	IN	denotes	into
T44075	70634-70637	DT	denotes	the
T44076	70648-70655	NN	denotes	chamber
T44077	70638-70647	JJ	denotes	metabolic
T44078	70656-70659	IN	denotes	for
T44079	70660-70661	CD	denotes	3
T44080	70662-70663	CD	denotes	5
T44081	70661-70662	SYM	denotes	–
T44082	70664-70667	NN	denotes	min
T44083	70668-70670	TO	denotes	to
T44084	70671-70676	VB	denotes	allow
T44085	70677-70680	DT	denotes	the
T44086	70681-70687	NN	denotes	system
T44087	70688-70690	TO	denotes	to
T44088	70691-70702	VB	denotes	equilibrate
T44089	70702-70703	.	denotes	.
T44090	70703-70821	sentence	denotes	Mice were then induced to run up an 18° incline at a speed of 40 m/min using a shock grid in the rear of the chamber.
T44091	70704-70708	NNS	denotes	Mice
T44092	70719-70726	VBN	denotes	induced
T44093	70709-70713	VBD	denotes	were
T44094	70714-70718	RB	denotes	then
T44095	70727-70729	TO	denotes	to
T44096	70730-70733	VB	denotes	run
T44097	70734-70736	IN	denotes	up
T44098	70737-70739	DT	denotes	an
T44099	70744-70751	NN	denotes	incline
T44100	70740-70742	CD	denotes	18
T44101	70742-70743	NN	denotes	°
T44102	70752-70754	IN	denotes	at
T44103	70755-70756	DT	denotes	a
T44104	70757-70762	NN	denotes	speed
T44105	70763-70765	IN	denotes	of
T44106	70766-70768	CD	denotes	40
T44107	70769-70770	NN	denotes	m
T44108	70770-70771	SYM	denotes	/
T44109	70771-70774	NN	denotes	min
T44110	70775-70780	VBG	denotes	using
T44111	70781-70782	DT	denotes	a
T44112	70789-70793	NN	denotes	grid
T44113	70783-70788	NN	denotes	shock
T44114	70794-70796	IN	denotes	in
T44115	70797-70800	DT	denotes	the
T44116	70801-70805	NN	denotes	rear
T44117	70806-70808	IN	denotes	of
T44118	70809-70812	DT	denotes	the
T44119	70813-70820	NN	denotes	chamber
T44120	70820-70821	.	denotes	.
T44121	70821-70911	sentence	denotes	The speed was increased by 5 m/min every 2 min until the animals were unable to continue.
T44122	70822-70825	DT	denotes	The
T44123	70826-70831	NN	denotes	speed
T44124	70836-70845	VBN	denotes	increased
T44125	70832-70835	VBD	denotes	was
T44126	70846-70848	IN	denotes	by
T44127	70849-70850	CD	denotes	5
T44128	70851-70852	NN	denotes	m
T44129	70852-70853	SYM	denotes	/
T44130	70853-70856	NN	denotes	min
T44131	70857-70862	DT	denotes	every
T44132	70865-70868	NN	denotes	min
T44133	70863-70864	CD	denotes	2
T44134	70869-70874	IN	denotes	until
T44135	70887-70891	VBD	denotes	were
T44136	70875-70878	DT	denotes	the
T44137	70879-70886	NNS	denotes	animals
T44138	70892-70898	JJ	denotes	unable
T44139	70899-70901	TO	denotes	to
T44140	70902-70910	VB	denotes	continue
T44141	70910-70911	.	denotes	.
T44142	70911-71049	sentence	denotes	Maximal effort was determined when oxygen uptake did not increase with power output and subsequently the mouse failed to maintain effort.
T44143	70912-70919	JJ	denotes	Maximal
T44144	70920-70926	NN	denotes	effort
T44145	70931-70941	VBN	denotes	determined
T44146	70927-70930	VBD	denotes	was
T44147	70942-70946	WRB	denotes	when
T44148	70969-70977	VB	denotes	increase
T44149	70947-70953	NN	denotes	oxygen
T44150	70954-70960	NN	denotes	uptake
T44151	70961-70964	VBD	denotes	did
T44152	70965-70968	RB	denotes	not
T44153	70978-70982	IN	denotes	with
T44154	70983-70988	NN	denotes	power
T44155	70989-70995	NN	denotes	output
T44156	70996-70999	CC	denotes	and
T44157	71000-71012	RB	denotes	subsequently
T44158	71023-71029	VBD	denotes	failed
T44159	71013-71016	DT	denotes	the
T44160	71017-71022	NN	denotes	mouse
T44161	71030-71032	TO	denotes	to
T44162	71033-71041	VB	denotes	maintain
T44163	71042-71048	NN	denotes	effort
T44164	71048-71049	.	denotes	.
T44165	71049-71168	sentence	denotes	VO2max was calculated using the averaged values over 1 min during which the animal's O2 consumption reached a plateau.
T44166	71050-71056	NN	denotes	VO2max
T44167	71061-71071	VBN	denotes	calculated
T44168	71057-71060	VBD	denotes	was
T44169	71072-71077	VBG	denotes	using
T44170	71078-71081	DT	denotes	the
T44171	71091-71097	NNS	denotes	values
T44172	71082-71090	JJ	denotes	averaged
T44173	71098-71102	IN	denotes	over
T44174	71103-71104	CD	denotes	1
T44175	71105-71108	NN	denotes	min
T44176	71109-71115	IN	denotes	during
T44177	71150-71157	VBD	denotes	reached
T44178	71116-71121	WDT	denotes	which
T44179	71122-71125	DT	denotes	the
T44180	71126-71132	NN	denotes	animal
T44181	71138-71149	NN	denotes	consumption
T44182	71132-71134	POS	denotes	's
T44183	71135-71137	NN	denotes	O2
T44184	71158-71159	DT	denotes	a
T44185	71160-71167	NN	denotes	plateau
T44186	71167-71168	.	denotes	.
T44806	71170-71178	JJ	denotes	Isolated
T44807	71198-71205	NNS	denotes	studies
T44808	71179-71185	NN	denotes	muscle
T44809	71186-71197	NN	denotes	stimulation
T44810	71205-71302	sentence	denotes	Animals were anesthetized with ketamine/xylazine and the soleus muscle was removed from one leg.
T44811	71206-71213	NNS	denotes	Animals
T44812	71219-71231	VBN	denotes	anesthetized
T44813	71214-71218	VBD	denotes	were
T44814	71232-71236	IN	denotes	with
T44815	71237-71245	NN	denotes	ketamine
T44816	71246-71254	NN	denotes	xylazine
T44817	71245-71246	HYPH	denotes	/
T44818	71255-71258	CC	denotes	and
T44819	71259-71262	DT	denotes	the
T44820	71270-71276	NN	denotes	muscle
T44821	71263-71269	NN	denotes	soleus
T44822	71281-71288	VBN	denotes	removed
T44823	71277-71280	VBD	denotes	was
T44824	71289-71293	IN	denotes	from
T44825	71294-71297	CD	denotes	one
T44826	71298-71301	NN	denotes	leg
T44827	71301-71302	.	denotes	.
T44828	71302-71393	sentence	denotes	Upon removal, the muscle was suspended in a Krebs solution aerated with 95% O2 and 5% CO2.
T44829	71303-71307	IN	denotes	Upon
T44830	71332-71341	VBN	denotes	suspended
T44831	71308-71315	NN	denotes	removal
T44832	71315-71317	,	denotes	,
T44833	71317-71320	DT	denotes	the
T44834	71321-71327	NN	denotes	muscle
T44835	71328-71331	VBD	denotes	was
T44836	71342-71344	IN	denotes	in
T44837	71345-71346	DT	denotes	a
T44838	71353-71361	NN	denotes	solution
T44839	71347-71352	NN	denotes	Krebs
T44840	71362-71369	VBN	denotes	aerated
T44841	71370-71374	IN	denotes	with
T44842	71375-71377	CD	denotes	95
T44843	71377-71378	NN	denotes	%
T44844	71379-71381	NN	denotes	O2
T44845	71382-71385	CC	denotes	and
T44846	71386-71387	CD	denotes	5
T44847	71387-71388	NN	denotes	%
T44848	71389-71392	NN	denotes	CO2
T44849	71392-71393	.	denotes	.
T44850	71393-71604	sentence	denotes	The muscle and Krebs solution were suspended within a water bath maintained at 37 °C, and the muscle was anchored to a Grass (West Warwick, Rhode Island, United States) isometric force transducer (model FTO3C).
T44851	71394-71397	DT	denotes	The
T44852	71398-71404	NN	denotes	muscle
T44853	71429-71438	VBN	denotes	suspended
T44854	71405-71408	CC	denotes	and
T44855	71409-71414	NN	denotes	Krebs
T44856	71415-71423	NN	denotes	solution
T44857	71424-71428	VBD	denotes	were
T44858	71439-71445	IN	denotes	within
T44859	71446-71447	DT	denotes	a
T44860	71454-71458	NN	denotes	bath
T44861	71448-71453	NN	denotes	water
T44862	71459-71469	VBN	denotes	maintained
T44863	71470-71472	IN	denotes	at
T44864	71473-71475	CD	denotes	37
T44865	71476-71478	NN	denotes	°C
T44866	71478-71480	,	denotes	,
T44867	71480-71483	CC	denotes	and
T44868	71484-71487	DT	denotes	the
T44869	71488-71494	NN	denotes	muscle
T44870	71499-71507	VBN	denotes	anchored
T44871	71495-71498	VBD	denotes	was
T44872	71508-71510	IN	denotes	to
T44873	71511-71512	DT	denotes	a
T44874	71579-71589	NN	denotes	transducer
T44875	71513-71518	NNP	denotes	Grass
T44876	71519-71520	-LRB-	denotes	(
T44877	71525-71532	NNP	denotes	Warwick
T44878	71520-71524	NNP	denotes	West
T44879	71532-71534	,	denotes	,
T44880	71534-71539	NNP	denotes	Rhode
T44881	71540-71546	NNP	denotes	Island
T44882	71546-71548	,	denotes	,
T44883	71548-71554	NNP	denotes	United
T44884	71555-71561	NNP	denotes	States
T44885	71561-71562	-RRB-	denotes	)
T44886	71563-71572	JJ	denotes	isometric
T44887	71573-71578	NN	denotes	force
T44888	71590-71591	-LRB-	denotes	(
T44889	71597-71602	NN	denotes	FTO3C
T44890	71591-71596	NN	denotes	model
T44891	71602-71603	-RRB-	denotes	)
T44892	71603-71604	.	denotes	.
T44893	71604-71759	sentence	denotes	Muscles were stimulated to contract with a Grass stimulator (model S88) generating a field stimulus through electrodes located at both ends of the muscle.
T44894	71605-71612	NNS	denotes	Muscles
T44895	71618-71628	VBN	denotes	stimulated
T44896	71613-71617	VBD	denotes	were
T44897	71629-71631	TO	denotes	to
T44898	71632-71640	VB	denotes	contract
T44899	71641-71645	IN	denotes	with
T44900	71646-71647	DT	denotes	a
T44901	71654-71664	NN	denotes	stimulator
T44902	71648-71653	NNP	denotes	Grass
T44903	71665-71666	-LRB-	denotes	(
T44904	71672-71675	NN	denotes	S88
T44905	71666-71671	NN	denotes	model
T44906	71675-71676	-RRB-	denotes	)
T44907	71677-71687	VBG	denotes	generating
T44908	71688-71689	DT	denotes	a
T44909	71696-71704	NN	denotes	stimulus
T44910	71690-71695	NN	denotes	field
T44911	71705-71712	IN	denotes	through
T44912	71713-71723	NNS	denotes	electrodes
T44913	71724-71731	VBN	denotes	located
T44914	71732-71734	IN	denotes	at
T44915	71735-71739	DT	denotes	both
T44916	71740-71744	NNS	denotes	ends
T44917	71745-71747	IN	denotes	of
T44918	71748-71751	DT	denotes	the
T44919	71752-71758	NN	denotes	muscle
T44920	71758-71759	.	denotes	.
T44921	71759-71882	sentence	denotes	Force-voltage (maximal force at about 100 V) and length-tension relationships were determined using single twitch stimuli.
T44922	71760-71765	NN	denotes	Force
T44923	71766-71773	NN	denotes	voltage
T44924	71765-71766	HYPH	denotes	-
T44925	71824-71837	NNS	denotes	relationships
T44926	71774-71775	-LRB-	denotes	(
T44927	71775-71782	JJ	denotes	maximal
T44928	71783-71788	NN	denotes	force
T44929	71789-71791	IN	denotes	at
T44930	71792-71797	JJ	denotes	about
T44931	71798-71801	CD	denotes	100
T44932	71802-71803	NN	denotes	V
T44933	71803-71804	-RRB-	denotes	)
T44934	71805-71808	CC	denotes	and
T44935	71809-71815	NN	denotes	length
T44936	71816-71823	NN	denotes	tension
T44937	71815-71816	HYPH	denotes	-
T44938	71843-71853	VBN	denotes	determined
T44939	71838-71842	VBD	denotes	were
T44940	71854-71859	VBG	denotes	using
T44941	71860-71866	JJ	denotes	single
T44942	71867-71873	NN	denotes	twitch
T44943	71874-71881	NNS	denotes	stimuli
T44944	71881-71882	.	denotes	.
T44945	71882-71978	sentence	denotes	The stimulator then delivered repeating trains of stimuli at one per second at 40 Hz for 2 min.
T44946	71883-71886	DT	denotes	The
T44947	71887-71897	NN	denotes	stimulator
T44948	71903-71912	VBD	denotes	delivered
T44949	71898-71902	RB	denotes	then
T44950	71913-71922	VBG	denotes	repeating
T44951	71923-71929	NNS	denotes	trains
T44952	71930-71932	IN	denotes	of
T44953	71933-71940	NNS	denotes	stimuli
T44954	71941-71943	IN	denotes	at
T44955	71944-71947	CD	denotes	one
T44956	71948-71951	IN	denotes	per
T44957	71952-71958	NN	denotes	second
T44958	71959-71961	IN	denotes	at
T44959	71962-71964	CD	denotes	40
T44960	71965-71967	NN	denotes	Hz
T44961	71968-71971	IN	denotes	for
T44962	71972-71973	CD	denotes	2
T44963	71974-71977	NN	denotes	min
T44964	71977-71978	.	denotes	.
T44965	71978-72106	sentence	denotes	Each train lasted 330 ms, and were digitally recorded using MacLab (AD Instruments, Colorado Springs, Colorado, United States).
T44966	71979-71983	DT	denotes	Each
T44967	71984-71989	NN	denotes	train
T44968	71990-71996	VBD	denotes	lasted
T44969	71997-72000	CD	denotes	330
T44970	72001-72003	NNS	denotes	ms
T44971	72003-72005	,	denotes	,
T44972	72005-72008	CC	denotes	and
T44973	72009-72013	VBD	denotes	were
T44974	72024-72032	VBN	denotes	recorded
T44975	72014-72023	RB	denotes	digitally
T44976	72033-72038	VBG	denotes	using
T44977	72039-72045	NNP	denotes	MacLab
T44978	72046-72047	-LRB-	denotes	(
T44979	72050-72061	NNPS	denotes	Instruments
T44980	72047-72049	NNP	denotes	AD
T44981	72061-72063	,	denotes	,
T44982	72063-72071	NNP	denotes	Colorado
T44983	72072-72079	NNP	denotes	Springs
T44984	72079-72081	,	denotes	,
T44985	72081-72089	NNP	denotes	Colorado
T44986	72089-72091	,	denotes	,
T44987	72091-72097	NNP	denotes	United
T44988	72098-72104	NNP	denotes	States
T44989	72104-72105	-RRB-	denotes	)
T44990	72105-72106	.	denotes	.
T44991	72106-72335	sentence	denotes	Fatigue resistance was calculated as the ratio of the force generated by the last tetanus divided by the highest force generated multiplied by 100 to give the percent of force generation that remained after the fatigue protocol.
T44992	72107-72114	NN	denotes	Fatigue
T44993	72115-72125	NN	denotes	resistance
T44994	72130-72140	VBN	denotes	calculated
T44995	72126-72129	VBD	denotes	was
T44996	72141-72143	IN	denotes	as
T44997	72144-72147	DT	denotes	the
T44998	72148-72153	NN	denotes	ratio
T44999	72154-72156	IN	denotes	of
T45000	72157-72160	DT	denotes	the
T45001	72161-72166	NN	denotes	force
T45002	72167-72176	VBN	denotes	generated
T45003	72177-72179	IN	denotes	by
T45004	72180-72183	DT	denotes	the
T45005	72189-72196	NN	denotes	tetanus
T45006	72184-72188	JJ	denotes	last
T45007	72197-72204	VBN	denotes	divided
T45008	72205-72207	IN	denotes	by
T45009	72208-72211	DT	denotes	the
T45010	72220-72225	NN	denotes	force
T45011	72212-72219	JJS	denotes	highest
T45012	72226-72235	VBN	denotes	generated
T45013	72236-72246	VBN	denotes	multiplied
T45014	72247-72249	IN	denotes	by
T45015	72250-72253	CD	denotes	100
T45016	72254-72256	TO	denotes	to
T45017	72257-72261	VB	denotes	give
T45018	72262-72265	DT	denotes	the
T45019	72266-72273	NN	denotes	percent
T45020	72274-72276	IN	denotes	of
T45021	72277-72282	NN	denotes	force
T45022	72283-72293	NN	denotes	generation
T45023	72294-72298	WDT	denotes	that
T45024	72299-72307	VBD	denotes	remained
T45025	72308-72313	IN	denotes	after
T45026	72314-72317	DT	denotes	the
T45027	72326-72334	NN	denotes	protocol
T45028	72318-72325	NN	denotes	fatigue
T45029	72334-72335	.	denotes	.
T45248	72501-72506	IN	denotes	until
T45249	72507-72517	NN	denotes	exhaustion
T45250	72517-72519	,	denotes	,
T45251	72529-72533	VBD	denotes	came
T45252	72519-72528	WDT	denotes	whichever
T45253	72534-72539	RB	denotes	first
T45254	72539-72540	.	denotes	.
T45255	72540-72720	sentence	denotes	Immediately following its treadmill run, the mouse was subjected to serial echocardiography using an Acuson Sequoia Echocardiography System performed as previously described [51].
T45256	72541-72552	RB	denotes	Immediately
T45257	72553-72562	IN	denotes	following
T45258	72596-72605	VBN	denotes	subjected
T45259	72563-72566	PRP$	denotes	its
T45260	72577-72580	NN	denotes	run
T45261	72567-72576	NN	denotes	treadmill
T45262	72580-72582	,	denotes	,
T45263	72582-72585	DT	denotes	the
T45264	72586-72591	NN	denotes	mouse
T45265	72592-72595	VBD	denotes	was
T45266	72606-72608	IN	denotes	to
T45267	72609-72615	JJ	denotes	serial
T45268	72616-72632	NN	denotes	echocardiography
T45269	72633-72638	VBG	denotes	using
T45270	72639-72641	DT	denotes	an
T45271	72674-72680	NNP	denotes	System
T45272	72642-72648	NNP	denotes	Acuson
T45273	72657-72673	NNP	denotes	Echocardiography
T45274	72649-72656	NNP	denotes	Sequoia
T45275	72681-72690	VBN	denotes	performed
T45276	72691-72693	IN	denotes	as
T45277	72705-72714	VBN	denotes	described
T45278	72694-72704	RB	denotes	previously
T45279	72715-72716	-LRB-	denotes	[
T45280	72716-72718	CD	denotes	51
T45281	72718-72719	-RRB-	denotes	]
T45282	72719-72720	.	denotes	.
T45734	72722-72724	FW	denotes	In
T45735	72725-72729	FW	denotes	vivo
T45736	72750-72757	NNS	denotes	studies
T45737	72730-72737	JJ	denotes	cardiac
T45738	72738-72749	JJ	denotes	hemodynamic
T45739	72757-72846	sentence	denotes	Hemodynamic studies were performed as previously described with some modifications [52].
T45740	72758-72769	JJ	denotes	Hemodynamic
T45741	72770-72777	NNS	denotes	studies
T45742	72783-72792	VBN	denotes	performed
T45743	72778-72782	VBD	denotes	were
T45744	72793-72795	IN	denotes	as
T45748	72822-72826	DT	denotes	some
T45749	72827-72840	NNS	denotes	modifications
T45750	72841-72842	-LRB-	denotes	[
T45751	72842-72844	CD	denotes	52
T45752	72844-72845	-RRB-	denotes	]
T45753	72845-72846	.	denotes	.
T45754	72846-72954	sentence	denotes	In brief, adult mice (10–12 wk) were anesthetized intraperitoneally (IP) with thiopental sodium (60 mg/kg).
T45755	72847-72849	IN	denotes	In
T45756	72884-72896	VBN	denotes	anesthetized
T45757	72850-72855	JJ	denotes	brief
T45758	72855-72857	,	denotes	,
T45759	72857-72862	JJ	denotes	adult
T45760	72863-72867	NNS	denotes	mice
T45761	72868-72869	-LRB-	denotes	(
T45762	72875-72877	NN	denotes	wk
T45763	72869-72871	CD	denotes	10
T45764	72872-72874	CD	denotes	12
T45765	72871-72872	SYM	denotes	–
T45766	72877-72878	-RRB-	denotes	)
T45767	72879-72883	VBD	denotes	were
T45768	72897-72914	RB	denotes	intraperitoneally
T45769	72915-72916	-LRB-	denotes	(
T45770	72916-72918	RB	denotes	IP
T45771	72918-72919	-RRB-	denotes	)
T45772	72920-72924	IN	denotes	with
T45773	72925-72935	NN	denotes	thiopental
T45774	72936-72942	NN	denotes	sodium
T45775	72943-72944	-LRB-	denotes	(
T45776	72947-72949	NN	denotes	mg
T45777	72944-72946	CD	denotes	60
T45778	72949-72950	SYM	denotes	/
T45779	72950-72952	NN	denotes	kg
T45780	72952-72953	-RRB-	denotes	)
T45781	72953-72954	.	denotes	.
T45782	72954-73020	sentence	denotes	The mice were intubated and ventilated with a Harvard ventilator.
T45783	72955-72958	DT	denotes	The
T45784	72959-72963	NNS	denotes	mice
T45785	72969-72978	VBN	denotes	intubated
T45786	72964-72968	VBD	denotes	were
T45787	72979-72982	CC	denotes	and
T45788	72983-72993	VBN	denotes	ventilated
T45789	72994-72998	IN	denotes	with
T45790	72999-73000	DT	denotes	a
T45791	73009-73019	NN	denotes	ventilator
T45792	73001-73008	NNP	denotes	Harvard
T45793	73019-73020	.	denotes	.
T45794	73020-73290	sentence	denotes	The right carotid artery was isolated in the region of the trachea and cannulated with a 1.4-French high-fidelity micromanometer catheter (Millar Instruments, Houston, Texas, United States), which was inserted into the left ventricle retrograde across the aortic valve.
T45795	73021-73024	DT	denotes	The
T45796	73039-73045	NN	denotes	artery
T45797	73025-73030	JJ	denotes	right
T45798	73031-73038	NN	denotes	carotid
T45799	73050-73058	VBN	denotes	isolated
T45800	73046-73049	VBD	denotes	was
T45801	73059-73061	IN	denotes	in
T45802	73062-73065	DT	denotes	the
T45803	73066-73072	NN	denotes	region
T45804	73073-73075	IN	denotes	of
T45805	73076-73079	DT	denotes	the
T45806	73080-73087	NN	denotes	trachea
T45807	73088-73091	CC	denotes	and
T45808	73092-73102	VBN	denotes	cannulated
T45809	73103-73107	IN	denotes	with
T45810	73108-73109	DT	denotes	a
T45811	73150-73158	NN	denotes	catheter
T45812	73110-73113	CD	denotes	1.4
T45813	73114-73120	NNP	denotes	French
T45814	73113-73114	HYPH	denotes	-
T45815	73121-73125	JJ	denotes	high
T45816	73126-73134	NN	denotes	fidelity
T45817	73125-73126	HYPH	denotes	-
T45818	73135-73149	NN	denotes	micromanometer
T45819	73159-73160	-LRB-	denotes	(
T45820	73167-73178	NNP	denotes	Instruments
T45821	73160-73166	NNP	denotes	Millar
T45822	73178-73180	,	denotes	,
T45823	73180-73187	NNP	denotes	Houston
T45824	73187-73189	,	denotes	,
T45825	73189-73194	NNP	denotes	Texas
T45826	73194-73196	,	denotes	,
T45827	73196-73202	NNP	denotes	United
T45828	73203-73209	NNP	denotes	States
T45829	73209-73210	-RRB-	denotes	)
T45830	73210-73212	,	denotes	,
T45831	73212-73217	WDT	denotes	which
T45832	73222-73230	VBN	denotes	inserted
T45833	73218-73221	VBD	denotes	was
T45834	73231-73235	IN	denotes	into
T45835	73236-73239	DT	denotes	the
T45836	73245-73254	NN	denotes	ventricle
T45837	73240-73244	JJ	denotes	left
T45838	73255-73265	RB	denotes	retrograde
T45839	73266-73272	IN	denotes	across
T45840	73273-73276	DT	denotes	the
T45841	73284-73289	NN	denotes	valve
T45842	73277-73283	JJ	denotes	aortic
T45843	73289-73290	.	denotes	.
T45844	73290-73485	sentence	denotes	Hemodynamic measurements were recorded at baseline and 3 min following continuous infusion of incremental doses of dobutamine (β1, β2, and α1-adrenergic agonist) up to 32 ng · gBW−1· min−1 [53].
T45845	73291-73302	JJ	denotes	Hemodynamic
T45846	73303-73315	NNS	denotes	measurements
T45847	73321-73329	VBN	denotes	recorded
T45848	73316-73320	VBD	denotes	were
T45849	73330-73332	IN	denotes	at
T45850	73333-73341	NN	denotes	baseline
T45851	73342-73345	CC	denotes	and
T45852	73346-73347	CD	denotes	3
T45853	73348-73351	NN	denotes	min
T45854	73352-73361	IN	denotes	following
T45855	73362-73372	JJ	denotes	continuous
T45856	73373-73381	NN	denotes	infusion
T45857	73382-73384	IN	denotes	of
T45858	73385-73396	JJ	denotes	incremental
T45859	73397-73402	NNS	denotes	doses
T45860	73403-73405	IN	denotes	of
T45861	73406-73416	NN	denotes	dobutamine
T45862	73417-73418	-LRB-	denotes	(
T45863	73418-73420	NN	denotes	β1
T45864	73433-73443	JJ	denotes	adrenergic
T45865	73420-73422	,	denotes	,
T45866	73422-73424	NN	denotes	β2
T45867	73424-73426	,	denotes	,
T45868	73426-73429	CC	denotes	and
T45869	73430-73432	NN	denotes	α1
T45870	73432-73433	HYPH	denotes	-
T45871	73444-73451	NN	denotes	agonist
T45872	73451-73452	-RRB-	denotes	)
T45873	73453-73455	IN	denotes	up
T45874	73456-73458	IN	denotes	to
T45875	73459-73461	CD	denotes	32
T45876	73462-73464	NN	denotes	ng
T45877	73465-73466	SYM	denotes	·
T45878	73467-73470	NN	denotes	gBW
T45879	73470-73471	SYM	denotes	−
T45880	73471-73472	CD	denotes	1
T45881	73472-73473	SYM	denotes	·
T45882	73474-73477	NN	denotes	min
T45883	73477-73478	SYM	denotes	−
T45884	73478-73479	CD	denotes	1
T45885	73480-73481	-LRB-	denotes	[
T45886	73481-73483	CD	denotes	53
T45887	73483-73484	-RRB-	denotes	]
T45888	73484-73485	.	denotes	.
T45889	73485-73659	sentence	denotes	Continuous pressure-volume data were acquired and digitized with the BioBench computer software data acquisition system (National Instruments, Austin, Texas, United States).
T45890	73486-73496	JJ	denotes	Continuous
T45891	73513-73517	NNS	denotes	data
T45892	73497-73505	NN	denotes	pressure
T45893	73506-73512	NN	denotes	volume
T45894	73505-73506	HYPH	denotes	-
T45895	73523-73531	VBN	denotes	acquired
T45896	73518-73522	VBD	denotes	were
T45897	73532-73535	CC	denotes	and
T45898	73536-73545	VBN	denotes	digitized
T45899	73546-73550	IN	denotes	with
T45900	73551-73554	DT	denotes	the
T45901	73599-73605	NN	denotes	system
T45902	73555-73563	NNP	denotes	BioBench
T45903	73573-73581	NN	denotes	software
T45904	73564-73572	NN	denotes	computer
T45905	73582-73586	NNS	denotes	data
T45906	73587-73598	NN	denotes	acquisition
T45907	73606-73607	-LRB-	denotes	(
T45908	73616-73627	NNPS	denotes	Instruments
T45909	73607-73615	NNP	denotes	National
T45910	73627-73629	,	denotes	,
T45911	73629-73635	NNP	denotes	Austin
T45912	73635-73637	,	denotes	,
T45913	73637-73642	NNP	denotes	Texas
T45914	73642-73644	,	denotes	,
T45915	73644-73650	NNP	denotes	United
T45916	73651-73657	NNP	denotes	States
T45917	73657-73658	-RRB-	denotes	)
T45918	73658-73659	.	denotes	.
T46753	73661-73669	VBN	denotes	Isolated
T46754	73690-73699	NN	denotes	perfusion
T46755	73670-73677	VBG	denotes	working
T46756	73678-73683	NN	denotes	mouse
T46757	73684-73689	NN	denotes	heart
T46758	73699-73790	sentence	denotes	Isolated working mouse heart perfusion was based on a previously described procedure [54].
T46759	73700-73708	VBN	denotes	Isolated
T46760	73729-73738	NN	denotes	perfusion
T46761	73709-73716	VBG	denotes	working
T46762	73717-73722	NN	denotes	mouse
T46763	73723-73728	NN	denotes	heart
T46764	73743-73748	VBN	denotes	based
T46765	73739-73742	VBD	denotes	was
T46766	73749-73751	IN	denotes	on
T46767	73752-73753	DT	denotes	a
T46768	73775-73784	NN	denotes	procedure
T46769	73754-73764	RB	denotes	previously
T46770	73765-73774	VBN	denotes	described
T46771	73785-73786	-LRB-	denotes	[
T46772	73786-73788	CD	denotes	54
T46773	73788-73789	-RRB-	denotes	]
T46774	73789-73790	.	denotes	.
T46775	73790-73874	sentence	denotes	Adult mice (4–7 mo old) were heparinized (100 units IP) 10 min prior to anesthesia.
T46776	73791-73796	JJ	denotes	Adult
T46777	73797-73801	NNS	denotes	mice
T46778	73820-73831	VBN	denotes	heparinized
T46779	73802-73803	-LRB-	denotes	(
T46780	73810-73813	JJ	denotes	old
T46781	73803-73804	CD	denotes	4
T46782	73805-73806	CD	denotes	7
T46783	73804-73805	SYM	denotes	–
T46784	73807-73809	NN	denotes	mo
T46785	73813-73814	-RRB-	denotes	)
T46786	73815-73819	VBD	denotes	were
T46787	73832-73833	-LRB-	denotes	(
T46788	73837-73842	NNS	denotes	units
T46789	73833-73836	CD	denotes	100
T46790	73843-73845	RB	denotes	IP
T46791	73845-73846	-RRB-	denotes	)
T46792	73847-73849	CD	denotes	10
T46793	73850-73853	NN	denotes	min
T46794	73860-73862	IN	denotes	to
T46795	73854-73859	JJ	denotes	prior
T46796	73863-73873	NN	denotes	anesthesia
T46797	73873-73874	.	denotes	.
T46798	73874-73953	sentence	denotes	Animals were then deeply anesthetized with 5–10 mg of sodium pentobarbital IP.
T46799	73875-73882	NNS	denotes	Animals
T46800	73900-73912	VBN	denotes	anesthetized
T46801	73883-73887	VBD	denotes	were
T46802	73888-73892	RB	denotes	then
T46803	73893-73899	RB	denotes	deeply
T46804	73913-73917	IN	denotes	with
T46805	73918-73919	CD	denotes	5
T46806	73920-73922	CD	denotes	10
T46807	73919-73920	SYM	denotes	–
T46808	73923-73925	NN	denotes	mg
T46809	73926-73928	IN	denotes	of
T46810	73929-73935	NN	denotes	sodium
T46811	73936-73949	NN	denotes	pentobarbital
T46812	73950-73952	RB	denotes	IP
T46813	73952-73953	.	denotes	.
T46814	73953-74162	sentence	denotes	Hearts were excised and placed in an ice-cold Krebs-Henseleit bicarbonate (KHB) solution [118 mM NaCl, 25 mM NaHCO3, 4.7 mM KCl, 1.2 mM KH2PO4, 2.5 mM CaCl2, 5.0 mM glucose, and 100 units/L insulin (pH 7.4)].
T46815	73954-73960	NNS	denotes	Hearts
T46816	73966-73973	VBN	denotes	excised
T46817	73961-73965	VBD	denotes	were
T46818	73974-73977	CC	denotes	and
T46819	73978-73984	VBN	denotes	placed
T46820	73985-73987	IN	denotes	in
T46821	73988-73990	DT	denotes	an
T46822	74034-74042	NN	denotes	solution
T46823	73991-73994	NN	denotes	ice
T46824	73995-73999	JJ	denotes	cold
T46825	73994-73995	HYPH	denotes	-
T46826	74000-74005	NN	denotes	Krebs
T46827	74006-74015	NN	denotes	Henseleit
T46828	74005-74006	HYPH	denotes	-
T46829	74016-74027	NN	denotes	bicarbonate
T46830	74028-74029	-LRB-	denotes	(
T46831	74029-74032	NN	denotes	KHB
T46832	74032-74033	-RRB-	denotes	)
T46833	74043-74044	-LRB-	denotes	[
T46834	74044-74047	CD	denotes	118
T46835	74048-74050	NN	denotes	mM
T46836	74051-74055	NN	denotes	NaCl
T46837	74055-74057	,	denotes	,
T46838	74057-74059	CD	denotes	25
T46839	74060-74062	NN	denotes	mM
T46840	74063-74069	NN	denotes	NaHCO3
T46841	74069-74071	,	denotes	,
T46842	74071-74074	CD	denotes	4.7
T46843	74075-74077	NN	denotes	mM
T46844	74078-74081	NN	denotes	KCl
T46845	74081-74083	,	denotes	,
T46846	74083-74086	CD	denotes	1.2
T46847	74087-74089	NN	denotes	mM
T46848	74090-74096	NN	denotes	KH2PO4
T46849	74096-74098	,	denotes	,
T46850	74098-74101	CD	denotes	2.5
T46851	74102-74104	NN	denotes	mM
T46852	74105-74110	NN	denotes	CaCl2
T46853	74110-74112	,	denotes	,
T46854	74112-74115	CD	denotes	5.0
T46855	74116-74118	NN	denotes	mM
T46856	74119-74126	NN	denotes	glucose
T46857	74126-74128	,	denotes	,
T46858	74128-74131	CC	denotes	and
T46859	74132-74135	CD	denotes	100
T46860	74136-74141	NNS	denotes	units
T46861	74141-74142	SYM	denotes	/
T46862	74144-74151	NN	denotes	insulin
T46863	74142-74143	NN	denotes	L
T46864	74152-74153	-LRB-	denotes	(
T46865	74153-74155	NN	denotes	pH
T46866	74156-74159	CD	denotes	7.4
T46867	74159-74160	-RRB-	denotes	)
T46868	74160-74161	-RRB-	denotes	]
T46869	74161-74162	.	denotes	.
T46870	74162-74258	sentence	denotes	Hearts were cannulated first via the aorta and perfused retrogradely by the Langendorff method.
T46871	74163-74169	NNS	denotes	Hearts
T46872	74175-74185	VBN	denotes	cannulated
T46873	74170-74174	VBD	denotes	were
T46874	74186-74191	RB	denotes	first
T46875	74192-74195	IN	denotes	via
T46876	74196-74199	DT	denotes	the
T46877	74200-74205	NN	denotes	aorta
T46878	74206-74209	CC	denotes	and
T46879	74210-74218	VBN	denotes	perfused
T46880	74219-74231	RB	denotes	retrogradely
T46881	74232-74234	IN	denotes	by
T46882	74235-74238	DT	denotes	the
T46883	74251-74257	NN	denotes	method
T46884	74239-74250	NNP	denotes	Langendorff
T46885	74257-74258	.	denotes	.
T46886	74258-74534	sentence	denotes	Following left atrial cannulation, perfusion was switched to the working mode with KHB solution containing 1.2 mM palmitate bound to 3% fatty acid-free BSA with a preload pressure of 11.5 mm Hg and an afterload pressure of 50 mm Hg for 60 min with oxygenated buffer solution.
T46887	74259-74268	VBG	denotes	Following
T46888	74308-74316	VBN	denotes	switched
T46889	74269-74273	JJ	denotes	left
T46890	74281-74292	NN	denotes	cannulation
T46891	74274-74280	JJ	denotes	atrial
T46892	74292-74294	,	denotes	,
T46893	74294-74303	NN	denotes	perfusion
T46894	74304-74307	VBD	denotes	was
T46895	74317-74319	IN	denotes	to
T46896	74320-74323	DT	denotes	the
T46897	74332-74336	NN	denotes	mode
T46898	74324-74331	VBG	denotes	working
T46899	74337-74341	IN	denotes	with
T46900	74383-74388	VBN	denotes	bound
T46901	74342-74345	NN	denotes	KHB
T46902	74346-74354	NN	denotes	solution
T46903	74355-74365	VBG	denotes	containing
T46904	74366-74369	CD	denotes	1.2
T46905	74370-74372	NN	denotes	mM
T46906	74373-74382	NN	denotes	palmitate
T46907	74389-74391	IN	denotes	to
T46908	74392-74393	CD	denotes	3
T46909	74393-74394	NN	denotes	%
T46910	74411-74414	NN	denotes	BSA
T46911	74395-74400	JJ	denotes	fatty
T46912	74401-74405	NN	denotes	acid
T46913	74406-74410	JJ	denotes	free
T46914	74405-74406	HYPH	denotes	-
T46915	74415-74419	IN	denotes	with
T46916	74420-74421	DT	denotes	a
T46917	74430-74438	NN	denotes	pressure
T46918	74422-74429	JJ	denotes	preload
T46919	74439-74441	IN	denotes	of
T46920	74442-74446	CD	denotes	11.5
T46921	74447-74449	NN	denotes	mm
T46922	74450-74452	NN	denotes	Hg
T46923	74453-74456	CC	denotes	and
T46924	74457-74459	DT	denotes	an
T46925	74470-74478	NN	denotes	pressure
T46926	74460-74469	JJ	denotes	afterload
T46927	74479-74481	IN	denotes	of
T46928	74482-74484	CD	denotes	50
T46929	74485-74487	NN	denotes	mm
T46930	74488-74490	NN	denotes	Hg
T46931	74491-74494	IN	denotes	for
T46932	74495-74497	CD	denotes	60
T46933	74498-74501	NN	denotes	min
T46934	74502-74506	IN	denotes	with
T46935	74507-74517	VBN	denotes	oxygenated
T46936	74525-74533	NN	denotes	solution
T46937	74518-74524	NN	denotes	buffer
T46938	74533-74534	.	denotes	.
T46939	74534-74908	sentence	denotes	Functional measurements, namely cardiac output, aortic flows, peak systolic pressure, and heart rate were acquired every 10 min using inline flow probes (Transonic Systems, Ithaca, New York, United States), a pressure transducer (TSD 104A, BIOPAC Systems, Santa Barbara, California, United States) and data acquired with the MP100 system from AcqKnowledge (BIOPAC Systems).
T46940	74535-74545	JJ	denotes	Functional
T46941	74546-74558	NNS	denotes	measurements
T46942	74641-74649	VBN	denotes	acquired
T46943	74558-74560	,	denotes	,
T46944	74560-74566	RB	denotes	namely
T46945	74575-74581	NN	denotes	output
T46946	74567-74574	JJ	denotes	cardiac
T46947	74581-74583	,	denotes	,
T46948	74583-74589	JJ	denotes	aortic
T46949	74590-74595	NNS	denotes	flows
T46950	74595-74597	,	denotes	,
T46951	74597-74601	JJ	denotes	peak
T46952	74611-74619	NN	denotes	pressure
T46953	74602-74610	JJ	denotes	systolic
T46954	74619-74621	,	denotes	,
T46955	74621-74624	CC	denotes	and
T46956	74625-74630	NN	denotes	heart
T46957	74631-74635	NN	denotes	rate
T46958	74636-74640	VBD	denotes	were
T46959	74650-74655	DT	denotes	every
T46960	74659-74662	NN	denotes	min
T46961	74656-74658	CD	denotes	10
T46962	74663-74668	VBG	denotes	using
T46963	74669-74675	NN	denotes	inline
T46964	74681-74687	NNS	denotes	probes
T46965	74676-74680	NN	denotes	flow
T46966	74688-74689	-LRB-	denotes	(
T46967	74699-74706	NNP	denotes	Systems
T46968	74689-74698	NNP	denotes	Transonic
T46969	74706-74708	,	denotes	,
T46970	74708-74714	NNP	denotes	Ithaca
T46971	74714-74716	,	denotes	,
T46972	74716-74719	NNP	denotes	New
T46973	74720-74724	NNP	denotes	York
T46974	74724-74726	,	denotes	,
T46975	74726-74732	NNP	denotes	United
T46976	74733-74739	NNP	denotes	States
T46977	74739-74740	-RRB-	denotes	)
T46978	74740-74742	,	denotes	,
T46979	74742-74743	DT	denotes	a
T46980	74753-74763	NN	denotes	transducer
T46981	74744-74752	NN	denotes	pressure
T46982	74764-74765	-LRB-	denotes	(
T46983	74769-74773	NN	denotes	104A
T46984	74765-74768	NN	denotes	TSD
T46985	74773-74775	,	denotes	,
T46986	74775-74781	NNP	denotes	BIOPAC
T46987	74782-74789	NNP	denotes	Systems
T46988	74789-74791	,	denotes	,
T46989	74791-74796	NNP	denotes	Santa
T46990	74797-74804	NNP	denotes	Barbara
T46991	74804-74806	,	denotes	,
T46992	74806-74816	NNP	denotes	California
T46993	74816-74818	,	denotes	,
T46994	74818-74824	NNP	denotes	United
T46995	74825-74831	NNP	denotes	States
T46996	74831-74832	-RRB-	denotes	)
T46997	74833-74836	CC	denotes	and
T46998	74837-74841	NNS	denotes	data
T46999	74842-74850	VBN	denotes	acquired
T47000	74851-74855	IN	denotes	with
T47001	74856-74859	DT	denotes	the
T47002	74866-74872	NN	denotes	system
T47003	74860-74865	NN	denotes	MP100
T47004	74873-74877	IN	denotes	from
T47005	74878-74890	NNP	denotes	AcqKnowledge
T47006	74891-74892	-LRB-	denotes	(
T47007	74899-74906	NNP	denotes	Systems
T47008	74892-74898	NNP	denotes	BIOPAC
T47009	74906-74907	-RRB-	denotes	)
T47010	74907-74908	.	denotes	.
T47011	74908-74997	sentence	denotes	Cardiac work was calculated as the product of peak systolic pressure and cardiac output.
T47012	74909-74916	JJ	denotes	Cardiac
T47013	74917-74921	NN	denotes	work
T47014	74926-74936	VBN	denotes	calculated
T47015	74922-74925	VBD	denotes	was
T47016	74937-74939	IN	denotes	as
T47017	74940-74943	DT	denotes	the
T47018	74944-74951	NN	denotes	product
T47019	74952-74954	IN	denotes	of
T47020	74955-74959	NN	denotes	peak
T47021	74969-74977	NN	denotes	pressure
T47022	74960-74968	JJ	denotes	systolic
T47023	74978-74981	CC	denotes	and
T47024	74982-74989	JJ	denotes	cardiac
T47025	74990-74996	NN	denotes	output
T47026	74996-74997	.	denotes	.
T47482	74999-75009	NNS	denotes	Statistics
T47483	75009-75109	sentence	denotes	Data were analyzed using T-tests or ANOVAs (measures of general activity and sensorimotor battery).
T47484	75010-75014	NNS	denotes	Data
T47485	75020-75028	VBN	denotes	analyzed
T47486	75015-75019	VBD	denotes	were
T47487	75029-75034	VBG	denotes	using
T47488	75035-75036	NN	denotes	T
T47489	75037-75042	NNS	denotes	tests
T47490	75036-75037	HYPH	denotes	-
T47491	75043-75045	CC	denotes	or
T47492	75046-75052	NNS	denotes	ANOVAs
T47493	75053-75054	-LRB-	denotes	(
T47494	75054-75062	NNS	denotes	measures
T47495	75063-75065	IN	denotes	of
T47496	75066-75073	JJ	denotes	general
T47497	75074-75082	NN	denotes	activity
T47498	75083-75086	CC	denotes	and
T47499	75087-75099	NN	denotes	sensorimotor
T47500	75100-75107	NN	denotes	battery
T47501	75107-75108	-RRB-	denotes	)
T47502	75108-75109	.	denotes	.
T47503	75109-75169	sentence	denotes	The level of significance was set at p < 0.05 in all cases.
T47504	75110-75113	DT	denotes	The
T47505	75114-75119	NN	denotes	level
T47506	75140-75143	VBN	denotes	set
T47507	75120-75122	IN	denotes	of
T47508	75123-75135	NN	denotes	significance
T47509	75136-75139	VBD	denotes	was
T47510	75144-75146	IN	denotes	at
T47511	75147-75148	NN	denotes	p
T47512	75149-75150	SYM	denotes	<
T47513	75151-75155	CD	denotes	0.05
T47514	75156-75158	IN	denotes	in
T47515	75159-75162	DT	denotes	all
T47516	75163-75168	NNS	denotes	cases
T47517	75168-75169	.	denotes	.
T47518	75169-75233	sentence	denotes	Data are reported as mean values ± SEM, unless otherwise noted.
T47519	75170-75174	NNS	denotes	Data
T47520	75179-75187	VBN	denotes	reported
T47521	75175-75178	VBP	denotes	are
T47522	75188-75190	IN	denotes	as
T47523	75191-75195	NN	denotes	mean
T47524	75196-75202	NNS	denotes	values
T47525	75203-75204	SYM	denotes	±
T47526	75205-75208	NN	denotes	SEM
T47527	75208-75210	,	denotes	,
T47528	75210-75216	IN	denotes	unless
T47529	75227-75232	VBN	denotes	noted
T47530	75217-75226	RB	denotes	otherwise
T47531	75232-75233	.	denotes	.
T47532	75233-75382	sentence	denotes	The ANOVA model used to analyze each sensorimotor test included one between-subjects variable (genotype), and one within-subjects variable (trials).
T47533	75234-75237	DT	denotes	The
T47534	75244-75249	NN	denotes	model
T47535	75238-75243	NN	denotes	ANOVA
T47536	75289-75297	VBD	denotes	included
T47537	75250-75254	VBN	denotes	used
T47538	75255-75257	TO	denotes	to
T47539	75258-75265	VB	denotes	analyze
T47540	75266-75270	DT	denotes	each
T47541	75284-75288	NN	denotes	test
T47542	75271-75283	NN	denotes	sensorimotor
T47543	75298-75301	CD	denotes	one
T47544	75302-75309	IN	denotes	between
T47545	75309-75310	HYPH	denotes	-
T47546	75310-75318	NNS	denotes	subjects
T47547	75319-75327	JJ	denotes	variable
T47548	75328-75329	-LRB-	denotes	(
T47549	75329-75337	NN	denotes	genotype
T47550	75337-75338	-RRB-	denotes	)
T47551	75338-75340	,	denotes	,
T47552	75340-75343	CC	denotes	and
T47553	75344-75347	CD	denotes	one
T47554	75348-75354	IN	denotes	within
T47555	75354-75355	HYPH	denotes	-
T47556	75355-75363	NNS	denotes	subjects
T47557	75364-75372	JJ	denotes	variable
T47558	75373-75374	-LRB-	denotes	(
T47559	75374-75380	NNS	denotes	trials
T47560	75380-75381	-RRB-	denotes	)
T47561	75381-75382	.	denotes	.
T47562	75382-75672	sentence	denotes	When ANOVAs with repeated measures were conducted, the Huynh-Feldt (H-F) adjustment of alpha levels was used for all within-subjects effects containing more than two levels, in order to protect against violations of the sphericity/compound symmetry assumptions underlying this ANOVA model.
T47563	75383-75387	WRB	denotes	When
T47564	75423-75432	VBN	denotes	conducted
T47565	75388-75394	NNS	denotes	ANOVAs
T47566	75395-75399	IN	denotes	with
T47567	75400-75408	VBN	denotes	repeated
T47568	75409-75417	NNS	denotes	measures
T47569	75418-75422	VBD	denotes	were
T47570	75487-75491	VBN	denotes	used
T47571	75432-75434	,	denotes	,
T47572	75434-75437	DT	denotes	the
T47573	75456-75466	NN	denotes	adjustment
T47574	75438-75443	NNP	denotes	Huynh
T47575	75444-75449	NNP	denotes	Feldt
T47576	75443-75444	HYPH	denotes	-
T47577	75450-75451	-LRB-	denotes	(
T47578	75451-75452	NN	denotes	H
T47579	75453-75454	NN	denotes	F
T47580	75452-75453	HYPH	denotes	-
T47581	75454-75455	-RRB-	denotes	)
T47582	75467-75469	IN	denotes	of
T47583	75470-75475	NN	denotes	alpha
T47584	75476-75482	NNS	denotes	levels
T47585	75483-75486	VBD	denotes	was
T47586	75492-75495	IN	denotes	for
T47587	75496-75499	DT	denotes	all
T47588	75516-75523	NNS	denotes	effects
T47589	75500-75506	IN	denotes	within
T47590	75506-75507	HYPH	denotes	-
T47591	75507-75515	NNS	denotes	subjects
T47592	75524-75534	VBG	denotes	containing
T47593	75535-75539	JJR	denotes	more
T47594	75545-75548	CD	denotes	two
T47595	75540-75544	IN	denotes	than
T47596	75549-75555	NNS	denotes	levels
T47597	75555-75557	,	denotes	,
T47598	75557-75559	IN	denotes	in
T47599	75560-75565	NN	denotes	order
T47600	75566-75568	TO	denotes	to
T47601	75569-75576	VB	denotes	protect
T47602	75577-75584	IN	denotes	against
T47603	75585-75595	NNS	denotes	violations
T47604	75596-75598	IN	denotes	of
T47605	75599-75602	DT	denotes	the
T47606	75632-75643	NNS	denotes	assumptions
T47607	75603-75613	NN	denotes	sphericity
T47608	75613-75614	HYPH	denotes	/
T47609	75614-75622	JJ	denotes	compound
T47610	75623-75631	NN	denotes	symmetry
T47611	75644-75654	VBG	denotes	underlying
T47612	75655-75659	DT	denotes	this
T47613	75666-75671	NN	denotes	model
T47614	75660-75665	NN	denotes	ANOVA
T47615	75671-75672	.	denotes	.
T47616	75672-75833	sentence	denotes	In addition, Bonferroni correction was used when appropriate to help maintain prescribed alpha levels (e.g., p < 0.05) when multiple comparisons were conducted.
T47617	75673-75675	IN	denotes	In
T47618	75712-75716	VBN	denotes	used
T47619	75676-75684	NN	denotes	addition
T47620	75684-75686	,	denotes	,
T47621	75686-75696	NNP	denotes	Bonferroni
T47622	75697-75707	NN	denotes	correction
T47623	75708-75711	VBD	denotes	was
T47624	75717-75721	WRB	denotes	when
T47625	75722-75733	JJ	denotes	appropriate
T47626	75734-75736	TO	denotes	to
T47627	75737-75741	VB	denotes	help
T47628	75742-75750	VB	denotes	maintain
T47629	75751-75761	VBN	denotes	prescribed
T47630	75768-75774	NNS	denotes	levels
T47631	75762-75767	NN	denotes	alpha
T47632	75775-75776	-LRB-	denotes	(
T47633	75782-75783	NN	denotes	p
T47634	75776-75780	FW	denotes	e.g.
T47635	75780-75782	,	denotes	,
T47636	75784-75785	SYM	denotes	<
T47637	75786-75790	CD	denotes	0.05
T47638	75790-75791	-RRB-	denotes	)
T47639	75792-75796	WRB	denotes	when
T47640	75823-75832	VBN	denotes	conducted
T47641	75797-75805	JJ	denotes	multiple
T47642	75806-75817	NNS	denotes	comparisons
T47643	75818-75822	VBD	denotes	were
T47644	75832-75833	.	denotes	.
T45218	72363-72368	JJ	denotes	Adult
T45219	72376-72380	NNS	denotes	mice
T45215	72337-72345	NN	denotes	Exercise
T45216	72346-72362	NN	denotes	echocardiography
T45217	72362-72540	sentence	denotes	Adult female mice (6–8 mo old) were exercised on the motorized treadmill using the run-to-exhaustion settings described above for 60 s or until exhaustion, whichever came first.
T45220	72369-72375	JJ	denotes	female
T45221	72399-72408	VBN	denotes	exercised
T45222	72381-72382	-LRB-	denotes	(
T45223	72382-72383	CD	denotes	6
T45224	72384-72385	CD	denotes	8
T45225	72383-72384	SYM	denotes	–
T45226	72386-72388	NN	denotes	mo
T45227	72389-72392	JJ	denotes	old
T45228	72392-72393	-RRB-	denotes	)
T45229	72394-72398	VBD	denotes	were
T45230	72409-72411	IN	denotes	on
T45231	72412-72415	DT	denotes	the
T45232	72426-72435	NN	denotes	treadmill
T45233	72416-72425	VBN	denotes	motorized
T45234	72436-72441	VBG	denotes	using
T45235	72442-72445	DT	denotes	the
T45236	72464-72472	NNS	denotes	settings
T45237	72446-72449	VB	denotes	run
T45238	72449-72450	HYPH	denotes	-
T45239	72450-72452	IN	denotes	to
T45240	72452-72453	HYPH	denotes	-
T45241	72453-72463	NN	denotes	exhaustion
T45242	72473-72482	VBN	denotes	described
T45243	72483-72488	RB	denotes	above
T45244	72489-72492	IN	denotes	for
T45245	72493-72495	CD	denotes	60
T45246	72496-72497	NN	denotes	s
T45247	72498-72500	CC	denotes	or
T729	0-134	sentence	denotes	PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
T33131	57119-57120	HYPH	denotes	-
T33132	57123-57127	JJ	denotes	null
T33133	57128-57132	NNS	denotes	mice
T33134	57141-57143	IN	denotes	in
T33135	57144-57147	DT	denotes	the
T33136	57158-57169	NN	denotes	environment
T33137	57148-57157	JJ	denotes	protected
T33138	57170-57172	IN	denotes	of
T33139	57173-57176	DT	denotes	the
T33140	57177-57187	NN	denotes	laboratory
T33141	57187-57189	,	denotes	,
T33142	57189-57192	PRP$	denotes	our
T33143	57193-57200	NNS	denotes	results
T33144	57210-57214	IN	denotes	that
T33145	57277-57279	VB	denotes	be
T33146	57215-57217	IN	denotes	in
T33147	57218-57221	DT	denotes	the
T33148	57222-57228	NNS	denotes	rigors
T33149	57229-57231	IN	denotes	of
T33150	57232-57233	DT	denotes	a
T33151	57251-57262	NN	denotes	environment
T33152	57234-57241	JJ	denotes	typical
T33153	57242-57250	JJ	denotes	external
R75	T809	T810	det	The,growth
R3	T727	T728	compound	PGC,1α
R4	T728	T731	compound	1α,Deficiency
R5	T730	T728	punct	-,1α
R6	T731	T732	nsubj	Deficiency,Causes
R7	T733	T734	nmod	Multi-System,Derangements
R9	T735	T734	nmod	Energy,Derangements
R10	T736	T734	amod	Metabolic,Derangements
R11	T737	T734	punct	: ,Derangements
R12	T738	T739	compound	Muscle,Dysfunction
R13	T739	T734	appos	Dysfunction,Derangements
R14	T740	T739	punct	", ",Dysfunction
R15	T741	T742	amod	Abnormal,Control
R16	T742	T739	conj	Control,Dysfunction
R17	T743	T742	compound	Weight,Control
R18	T744	T742	cc	and,Control
R19	T745	T746	amod	Hepatic,Steatosis
R20	T746	T742	conj	Steatosis,Control
R21	T749	T750	det	The,gene
R22	T750	T751	nsubjpass	gene,targeted
R23	T752	T750	acl	encoding,gene
R24	T753	T754	det	the,coactivator
R25	T754	T752	dobj	coactivator,encoding
R26	T755	T754	amod	transcriptional,coactivator
R27	T756	T757	compound	peroxisome,proliferator
R28	T757	T758	npadvmod	proliferator,activated
R29	T758	T760	amod	activated,1α
R30	T759	T758	punct	-,activated
R31	T760	T754	appos	1α,coactivator
R32	T761	T760	nmod	receptor,1α
R33	T762	T760	punct	-,1α
R34	T763	T760	punct	γ,1α
R35	T764	T760	compound	coactivator,1α
R36	T765	T760	punct	-,1α
R37	T766	T760	punct	(,1α
R38	T767	T768	compound	PGC,1α
R39	T768	T760	appos	1α,1α
R40	T769	T768	punct	-,1α
R41	T770	T760	punct	),1α
R42	T771	T751	auxpass	was,targeted
R43	T772	T751	prep	in,targeted
R44	T773	T772	pobj	mice,in
R45	T774	T751	punct	.,targeted
R46	T776	T777	compound	PGC,1α
R47	T777	T779	npadvmod	1α,null
R48	T778	T777	punct	-,1α
R49	T779	T780	amod	null,1α
R50	T780	T784	nmod	1α,mice
R51	T781	T780	punct	(,1α
R52	T782	T780	nmod	PGC,1α
R53	T783	T780	punct	-,1α
R54	T784	T789	nsubj	mice,were
R55	T785	T780	punct	−,1α
R56	T786	T780	punct	/,1α
R57	T787	T780	punct	−,1α
R58	T788	T780	punct	),1α
R59	T790	T789	acomp	viable,were
R60	T791	T789	punct	.,were
R61	T793	T794	advmod	However,revealed
R62	T795	T794	punct	", ",revealed
R63	T796	T797	amod	extensive,phenotyping
R64	T797	T794	nsubj	phenotyping,revealed
R65	T798	T799	amod	multi-system,abnormalities
R66	T799	T794	dobj	abnormalities,revealed
R67	T800	T799	amod	indicative,abnormalities
R68	T801	T800	prep	of,indicative
R69	T802	T803	det	an,phenotype
R70	T803	T801	pobj	phenotype,of
R71	T804	T803	amod	abnormal,phenotype
R72	T805	T803	nmod	energy,phenotype
R73	T806	T803	amod	metabolic,phenotype
R74	T807	T794	punct	.,revealed
R76	T810	T812	nsubjpass	growth,blunted
R77	T811	T810	amod	postnatal,growth
R78	T813	T810	prep	of,growth
R79	T814	T813	pobj	heart,of
R80	T815	T814	cc	and,heart
R81	T816	T817	amod	slow,twitch
R82	T817	T819	nmod	twitch,muscle
R83	T818	T817	punct	-,twitch
R84	T819	T814	conj	muscle,heart
R85	T820	T819	amod	skeletal,muscle
R86	T821	T814	punct	", ",heart
R87	T822	T814	appos	organs,heart
R88	T823	T822	prep	with,organs
R89	T824	T825	amod	high,demands
R91	T826	T825	amod	mitochondrial,demands
R92	T827	T825	compound	energy,demands
R93	T828	T812	punct	", ",blunted
R94	T829	T812	auxpass	is,blunted
R95	T830	T812	prep	in,blunted
R96	T831	T832	nmod	PGC,1α
R97	T832	T834	nmod	1α,mice
R98	T833	T832	punct	-,1α
R99	T834	T830	pobj	mice,in
R100	T835	T832	punct	−,1α
R101	T836	T832	punct	/,1α
R102	T837	T832	punct	−,1α
R103	T838	T812	punct	.,blunted
R104	T840	T841	prep	With,develop
R105	T842	T840	pobj	age,With
R106	T843	T841	punct	", ",develop
R107	T844	T845	det	the,mice
R108	T845	T841	nsubj	mice,develop
R109	T846	T847	nmod	PGC,1α
R110	T847	T845	nmod	1α,mice
R111	T848	T847	punct	-,1α
R112	T849	T847	punct	−,1α
R113	T850	T847	punct	/,1α
R114	T851	T847	punct	−,1α
R115	T852	T853	advmod	abnormally,increased
R116	T853	T854	amod	increased,fat
R117	T854	T841	dobj	fat,develop
R118	T855	T854	compound	body,fat
R119	T856	T854	punct	", ",fat
R120	T857	T858	det	a,phenotype
R121	T858	T854	appos	phenotype,fat
R122	T859	T860	dep	that,is
R123	T860	T858	relcl	is,phenotype
R124	T861	T862	advmod	more,severe
R125	T862	T860	acomp	severe,is
R126	T863	T860	prep	in,is
R127	T864	T863	pobj	females,in
R128	T865	T841	punct	.,develop
R129	T867	T868	amod	Mitochondrial,number
R130	T868	T869	nsubjpass	number,diminished
R131	T870	T868	cc	and,number
R132	T871	T872	amod	respiratory,capacity
R133	T872	T868	conj	capacity,number
R134	T873	T869	auxpass	is,diminished
R135	T874	T869	prep	in,diminished
R136	T875	T876	amod	slow,twitch
R137	T876	T878	nmod	twitch,muscle
R138	T877	T876	punct	-,twitch
R139	T878	T874	pobj	muscle,in
R140	T879	T878	amod	skeletal,muscle
R141	T880	T878	prep	of,muscle
R142	T881	T882	nmod	PGC,1α
R143	T882	T884	nmod	1α,mice
R144	T883	T882	punct	-,1α
R145	T884	T880	pobj	mice,of
R146	T885	T882	punct	−,1α
R147	T886	T882	punct	/,1α
R148	T887	T882	punct	−,1α
R149	T888	T869	punct	", ",diminished
R150	T889	T869	advcl	leading,diminished
R151	T890	T889	prep	to,leading
R152	T891	T892	amod	reduced,performance
R153	T892	T890	pobj	performance,to
R154	T893	T892	compound	muscle,performance
R155	T894	T892	cc	and,performance
R156	T895	T896	compound	exercise,capacity
R157	T896	T892	conj	capacity,performance
R158	T897	T869	punct	.,diminished
R159	T899	T900	nmod	PGC,1α
R160	T900	T902	nmod	1α,mice
R161	T901	T900	punct	-,1α
R162	T902	T906	nsubj	mice,exhibit
R163	T903	T900	punct	−,1α
R164	T904	T900	punct	/,1α
R165	T905	T900	punct	−,1α
R166	T907	T908	det	a,diminution
R167	T908	T906	dobj	diminution,exhibit
R168	T909	T908	amod	modest,diminution
R169	T910	T908	prep	in,diminution
R170	T911	T912	amod	cardiac,function
R171	T912	T910	pobj	function,in
R172	T913	T908	acl	related,diminution
R173	T914	T913	advmod	largely,related
R174	T915	T913	prep	to,related
R175	T916	T917	amod	abnormal,control
R176	T917	T915	pobj	control,to
R177	T918	T917	prep	of,control
R178	T919	T920	compound	heart,rate
R179	T920	T918	pobj	rate,of
R180	T921	T906	punct	.,exhibit
R181	T923	T924	det	The,mice
R182	T924	T931	nsubj	mice,were
R183	T925	T926	nmod	PGC,1α
R184	T926	T924	nmod	1α,mice
R185	T927	T926	punct	-,1α
R186	T928	T926	punct	−,1α
R187	T929	T926	punct	/,1α
R188	T930	T926	punct	−,1α
R189	T932	T931	acomp	unable,were
R190	T933	T934	aux	to,maintain
R191	T934	T932	xcomp	maintain,unable
R192	T935	T936	compound	core,temperature
R193	T936	T934	dobj	temperature,maintain
R194	T937	T936	compound	body,temperature
R195	T938	T934	prep	following,maintain
R196	T939	T938	pobj	exposure,following
R197	T940	T939	prep	to,exposure
R198	T941	T940	pobj	cold,to
R199	T942	T931	punct	", ",were
R200	T943	T931	advcl	consistent,were
R201	T944	T943	prep	with,consistent
R202	T945	T946	det	an,response
R204	T947	T946	amod	altered,response
R205	T948	T946	amod	thermogenic,response
R206	T949	T931	punct	.,were
R207	T951	T952	prep	Following,develop
R208	T953	T954	amod	short,term
R209	T954	T956	compound	term,starvation
R210	T955	T954	punct	-,term
R211	T956	T951	pobj	starvation,Following
R212	T957	T952	punct	", ",develop
R213	T958	T959	nmod	PGC,1α
R214	T959	T961	nmod	1α,mice
R215	T960	T959	punct	-,1α
R216	T961	T952	nsubj	mice,develop
R217	T962	T959	punct	−,1α
R218	T963	T959	punct	/,1α
R219	T964	T959	punct	−,1α
R220	T965	T966	amod	hepatic,steatosis
R221	T966	T952	dobj	steatosis,develop
R222	T967	T952	prep	due,develop
R223	T968	T967	pcomp	to,due
R224	T969	T970	det	a,combination
R225	T970	T967	pobj	combination,due
R226	T971	T970	prep	of,combination
R227	T972	T973	amod	reduced,capacity
R229	T974	T973	amod	mitochondrial,capacity
R230	T975	T973	amod	respiratory,capacity
R231	T976	T973	cc	and,capacity
R232	T977	T978	det	an,expression
R233	T978	T973	conj	expression,capacity
R234	T979	T978	amod	increased,expression
R235	T980	T978	prep	of,expression
R236	T981	T982	amod	lipogenic,genes
R237	T982	T980	pobj	genes,of
R238	T983	T952	punct	.,develop
R239	T985	T986	advmod	Surprisingly,were
R240	T987	T986	punct	", ",were
R241	T988	T989	nmod	PGC,1α
R242	T989	T991	nmod	1α,mice
R243	T990	T989	punct	-,1α
R244	T991	T986	nsubj	mice,were
R245	T992	T989	punct	−,1α
R246	T993	T989	punct	/,1α
R247	T994	T989	punct	−,1α
R248	T995	T996	advmod	less,susceptible
R249	T996	T986	acomp	susceptible,were
R250	T997	T996	prep	to,susceptible
R251	T998	T999	npadvmod	diet,induced
R252	T999	T1001	amod	induced,resistance
R253	T1000	T999	punct	-,induced
R254	T1001	T997	pobj	resistance,to
R255	T1002	T1001	compound	insulin,resistance
R256	T1003	T996	prep	than,susceptible
R257	T1004	T1005	amod	wild,type
R258	T1005	T1007	compound	type,controls
R259	T1006	T1005	punct	-,type
R260	T1007	T1003	pobj	controls,than
R261	T1008	T986	punct	.,were
R262	T1010	T1011	advmod	Lastly,detected
R263	T1012	T1011	punct	", ",detected
R264	T1013	T1014	amod	vacuolar,lesions
R265	T1014	T1011	nsubjpass	lesions,detected
R266	T1015	T1011	auxpass	were,detected
R267	T1016	T1011	prep	in,detected
R268	T1017	T1018	det	the,system
R270	T1019	T1018	amod	central,system
R271	T1020	T1018	amod	nervous,system
R272	T1021	T1018	prep	of,system
R273	T1022	T1023	nmod	PGC,1α
R274	T1023	T1025	nmod	1α,mice
R275	T1024	T1023	punct	-,1α
R276	T1025	T1021	pobj	mice,of
R277	T1026	T1023	punct	−,1α
R278	T1027	T1023	punct	/,1α
R279	T1028	T1023	punct	−,1α
R280	T1029	T1011	punct	.,detected
R281	T1031	T1032	det	These,results
R282	T1032	T1033	nsubj	results,demonstrate
R283	T1034	T1035	mark	that,is
R284	T1035	T1033	ccomp	is,demonstrate
R285	T1036	T1037	compound	PGC,1α
R286	T1037	T1035	nsubj	1α,is
R287	T1038	T1037	punct	-,1α
R288	T1039	T1035	acomp	necessary,is
R289	T1040	T1039	prep	for,necessary
R290	T1041	T1042	amod	appropriate,adaptation
R291	T1042	T1040	pobj	adaptation,for
R292	T1043	T1042	prep	to,adaptation
R293	T1044	T1045	det	the,stressors
R294	T1045	T1043	pobj	stressors,to
R295	T1046	T1045	amod	metabolic,stressors
R296	T1047	T1046	cc	and,metabolic
R297	T1048	T1046	conj	physiologic,metabolic
R298	T1049	T1045	prep	of,stressors
R299	T1050	T1051	amod	postnatal,life
R300	T1051	T1049	pobj	life,of
R301	T1052	T1033	punct	.,demonstrate
R324	T3501	T3502	amod	Mitochondrial,capacity
R330	T3502	T3504	nsubjpass	capacity,regulated
R331	T3503	T3502	amod	functional,capacity
R332	T3505	T3504	auxpass	is,regulated
R333	T3506	T3504	advmod	dynamically,regulated
R334	T3507	T3508	aux	to,meet
R335	T3508	T3504	advcl	meet,regulated
R336	T3509	T3510	det	the,demands
R337	T3510	T3508	dobj	demands,meet
R338	T3511	T3510	amod	diverse,demands
R339	T3512	T3510	compound	energy,demands
R340	T3513	T3510	acl	imposed,demands
R341	T3514	T3513	prep	on,imposed
R342	T3515	T3516	det	the,organism
R343	T3516	T3514	pobj	organism,on
R344	T3517	T3516	amod	mammalian,organism
R345	T3518	T3513	prep	following,imposed
R346	T3519	T3518	pobj	birth,following
R347	T3530	T3531	amod	transcriptional,regulatory
R348	T3531	T3528	conj	regulatory,signaling
R349	T3520	T3504	punct	.,regulated
R350	T3532	T3533	dep	that,control
R351	T3533	T3527	relcl	control,pathways
R352	T3534	T3535	det	the,expression
R353	T3535	T3533	dobj	expression,control
R354	T3536	T3535	amod	coordinate,expression
R355	T3537	T3535	prep	of,expression
R356	T3538	T3539	amod	nuclear,genes
R357	T3539	T3537	pobj	genes,of
R358	T3522	T3523	amod	Postnatal,biogenesis
R359	T3540	T3538	cc	and,nuclear
R360	T3541	T3538	conj	mitochondrial,nuclear
R361	T3542	T3539	acl	involved,genes
R362	T3543	T3542	prep	in,involved
R363	T3523	T3525	nsubj	biogenesis,involves
R364	T3544	T3545	amod	mitochondrial,structure
R365	T3545	T3543	pobj	structure,in
R366	T3524	T3523	amod	mitochondrial,biogenesis
R367	T3546	T3545	punct	", ",structure
R368	T3547	T3545	conj	metabolism,structure
R369	T3526	T3527	amod	multiple,pathways
R370	T3548	T3547	punct	", ",metabolism
R371	T3549	T3547	cc	and,metabolism
R372	T3550	T3547	conj	proliferation,metabolism
R373	T3551	T3552	punct	[,1
R374	T3552	T3533	parataxis	1,control
R375	T3553	T3552	punct	],1
R376	T3527	T3525	dobj	pathways,involves
R377	T3554	T3525	punct	.,involves
R378	T3556	T3557	amod	Recent,evidence
R379	T3528	T3527	nmod	signaling,pathways
R380	T3557	T3558	nsubj	evidence,points
R381	T3529	T3528	cc	and,signaling
R382	T3559	T3558	prep	toward,points
R383	T3560	T3561	det	a,coactivator
R384	T3561	T3559	pobj	coactivator,toward
R385	T3562	T3561	amod	transcriptional,coactivator
R386	T3635	T3633	pobj	receptor,with
R387	T3563	T3561	punct	", ",coactivator
R388	T3564	T3565	compound	peroxisome,proliferator
R389	T3565	T3566	npadvmod	proliferator,activated
R390	T3566	T3568	amod	activated,receptor
R391	T3567	T3566	punct	-,activated
R392	T3636	T3635	amod	adipogenic,receptor
R393	T3568	T3569	nmod	receptor,1α
R394	T3569	T3561	appos	1α,coactivator
R395	T3570	T3568	punct	-,receptor
R396	T3637	T3635	amod	nuclear,receptor
R397	T3571	T3568	punct	γ,receptor
R398	T3572	T3568	punct	(,receptor
R399	T3638	T3635	appos	PPARγ,receptor
R400	T3573	T3568	appos	PPARγ,receptor
R401	T3574	T3569	punct	),1α
R402	T3575	T3569	compound	coactivator,1α
R403	T3576	T3569	punct	-,1α
R404	T3577	T3569	punct	(,1α
R405	T3578	T3579	compound	PGC,1α
R406	T3579	T3569	appos	1α,1α
R407	T3639	T3640	punct	[,2
R408	T3580	T3579	punct	-,1α
R409	T3581	T3561	punct	),coactivator
R410	T3582	T3561	punct	", ",coactivator
R411	T3640	T3616	parataxis	2,discovered
R412	T3583	T3561	prep	as,coactivator
R413	T3584	T3585	det	an,integrator
R414	T3585	T3583	pobj	integrator,as
R415	T3641	T3640	punct	],2
R416	T3586	T3585	prep	of,integrator
R417	T3587	T3588	det	the,circuitry
R418	T3642	T3616	punct	.,discovered
R419	T3588	T3586	pobj	circuitry,of
R420	T3644	T3645	advmod	Subsequently,identified
R421	T3589	T3588	amod	molecular,circuitry
R422	T3590	T3588	amod	regulatory,circuitry
R423	T3591	T3588	acl	involved,circuitry
R424	T3592	T3591	prep	in,involved
R425	T3646	T3645	punct	", ",identified
R426	T3593	T3594	det	the,control
R427	T3594	T3592	pobj	control,in
R428	T3595	T3594	amod	transcriptional,control
R429	T3596	T3594	prep	of,control
R430	T3647	T3648	nummod	two,members
R431	T3597	T3598	amod	cellular,metabolism
R432	T3598	T3596	pobj	metabolism,of
R433	T3599	T3598	compound	energy,metabolism
R434	T3648	T3645	nsubjpass	members,identified
R435	T3600	T3588	punct	", ",circuitry
R436	T3601	T3588	prep	including,circuitry
R437	T3602	T3603	amod	mitochondrial,function
R439	T3603	T3601	pobj	function,including
R440	T3604	T3603	cc	and,function
R441	T3605	T3603	conj	biogenesis,function
R442	T3650	T3648	nmod	PGC,members
R443	T3606	T3607	punct	[,2
R444	T3607	T3558	parataxis	2,points
R445	T3608	T3607	nummod	1,2
R446	T3609	T3607	punct	",",2
R447	T3651	T3650	punct	-,PGC
R448	T3610	T3607	punct	],2
R449	T3611	T3558	punct	.,points
R450	T3652	T3650	nummod	1,PGC
R451	T3653	T3648	compound	family,members
R452	T3613	T3614	compound	PGC,1α
R453	T3654	T3645	auxpass	were,identified
R454	T3614	T3616	nsubjpass	1α,discovered
R455	T3615	T3614	punct	-,1α
R456	T3617	T3616	auxpass	was,discovered
R457	T3618	T3616	prep	in,discovered
R458	T3655	T3645	punct	", ",identified
R459	T3619	T3620	det	a,screen
R460	T3620	T3618	pobj	screen,in
R461	T3656	T3657	npadvmod	PGC,related
R462	T3621	T3620	nmod	yeast,screen
R463	T3622	T3623	nummod	two,hybrid
R464	T3623	T3620	compound	hybrid,screen
R465	T3657	T3660	amod	related,coactivator
R466	T3624	T3623	punct	-,hybrid
R467	T3625	T3620	prep	for,screen
R468	T3626	T3627	amod	brown,adipose
R469	T3658	T3656	punct	-,PGC
R470	T3627	T3628	npadvmod	adipose,specific
R471	T3628	T3630	amod	specific,factors
R472	T3629	T3628	punct	-,specific
R473	T3659	T3656	nummod	1,PGC
R474	T3630	T3625	pobj	factors,for
R475	T3660	T3645	dobj	coactivator,identified
R476	T3631	T3632	dep	that,interact
R477	T3632	T3630	relcl	interact,factors
R478	T3633	T3632	prep	with,interact
R479	T3634	T3635	det	the,receptor
R480	T3661	T3660	punct	(,coactivator
R481	T3662	T3660	appos	PRC,coactivator
R482	T3663	T3660	punct	),coactivator
R483	T3664	T3665	punct	[,3
R484	T3665	T3660	parataxis	3,coactivator
R485	T3740	T3741	punct	[,7
R486	T3741	T3707	parataxis	7,is
R487	T3742	T3741	nummod	2,7
R488	T3666	T3665	punct	],3
R489	T3743	T3741	punct	",",7
R490	T3744	T3741	nummod	6,7
R491	T3745	T3741	punct	",",7
R492	T3746	T3741	punct	],7
R493	T3667	T3660	cc	and,coactivator
R494	T3747	T3707	punct	.,is
R495	T3668	T3669	compound	PGC,1β
R496	T3749	T3750	compound	PGC,1α
R497	T3750	T3752	nsubjpass	1α,enriched
R498	T3751	T3750	punct	-,1α
R499	T3669	T3660	conj	1β,coactivator
R500	T3753	T3752	auxpass	is,enriched
R501	T3754	T3752	prep	in,enriched
R502	T3670	T3669	punct	-,1β
R503	T3755	T3756	amod	brown,tissue
R504	T3756	T3754	pobj	tissue,in
R505	T3757	T3756	compound	adipose,tissue
R506	T3671	T3672	punct	[,5
R507	T3758	T3756	punct	(,tissue
R508	T3759	T3756	appos	BAT,tissue
R509	T3760	T3756	punct	),tissue
R510	T3761	T3756	punct	", ",tissue
R511	T3762	T3756	conj	heart,tissue
R512	T3763	T3762	punct	", ",heart
R513	T3672	T3669	parataxis	5,1β
R514	T3764	T3765	amod	slow,twitch
R515	T3765	T3767	nmod	twitch,muscle
R516	T3766	T3765	punct	-,twitch
R517	T3673	T3672	nummod	4,5
R518	T3674	T3672	punct	",",5
R519	T3767	T3762	conj	muscle,heart
R520	T3768	T3767	amod	skeletal,muscle
R521	T3675	T3672	punct	],5
R522	T3769	T3767	punct	", ",muscle
R523	T3770	T3767	cc	and,muscle
R524	T3771	T3767	conj	kidney,muscle
R525	T3676	T3645	punct	.,identified
R526	T3772	T3756	punct	—,tissue
R527	T3773	T3774	advmod	all,tissues
R528	T3774	T3756	appos	tissues,tissue
R529	T3678	T3679	compound	PGC,1α
R530	T3775	T3774	prep	with,tissues
R531	T3776	T3777	amod	high,capacity
R532	T3777	T3779	nmod	capacity,systems
R533	T3679	T3681	nsubj	1α,serves
R534	T3778	T3777	punct	-,capacity
R535	T3779	T3775	pobj	systems,with
R536	T3780	T3779	amod	mitochondrial,systems
R537	T3680	T3679	punct	-,1α
R538	T3781	T3752	punct	.,enriched
R539	T3783	T3784	det	The,expression
R540	T3682	T3681	prep	as,serves
R541	T3784	T3785	nsubjpass	expression,induced
R542	T3683	T3684	det	a,coactivator
R543	T3684	T3682	pobj	coactivator,as
R544	T3786	T3784	prep	of,expression
R545	T3787	T3788	det	the,gene
R546	T3685	T3684	amod	direct,coactivator
R547	T3788	T3786	pobj	gene,of
R548	T3789	T3788	acl	encoding,gene
R549	T3790	T3791	compound	PGC,1α
R550	T3686	T3684	amod	transcriptional,coactivator
R551	T3791	T3789	dobj	1α,encoding
R552	T3792	T3791	punct	-,1α
R553	T3687	T3684	prep	of,coactivator
R554	T3793	T3785	auxpass	is,induced
R555	T3794	T3785	advmod	rapidly,induced
R556	T3688	T3689	amod	nuclear,factors
R557	T3795	T3785	agent	by,induced
R558	T3796	T3797	compound	cold,exposure
R559	T3797	T3795	pobj	exposure,by
R560	T3798	T3797	punct	", ",exposure
R561	T3799	T3800	amod	short,term
R562	T3800	T3802	compound	term,exercise
R563	T3689	T3687	pobj	factors,of
R564	T3801	T3800	punct	-,term
R565	T3802	T3797	conj	exercise,exposure
R566	T3803	T3802	punct	", ",exercise
R567	T3690	T3688	cc	and,nuclear
R568	T3804	T3802	cc	and,exercise
R569	T3805	T3802	conj	fasting,exercise
R570	T3806	T3807	punct	[,15
R571	T3807	T3785	parataxis	15,induced
R572	T3808	T3807	nummod	2,15
R573	T3809	T3807	punct	",",15
R574	T3691	T3688	conj	nonnuclear,nuclear
R575	T3810	T3807	nummod	8,15
R576	T3811	T3807	punct	",",15
R577	T3812	T3807	nummod	9,15
R578	T3813	T3807	punct	",",15
R579	T3692	T3689	compound	receptor,factors
R580	T3814	T3807	nummod	10,15
R581	T3815	T3807	punct	",",15
R582	T3816	T3807	nummod	11,15
R583	T3693	T3689	compound	transcription,factors
R584	T3817	T3807	punct	",",15
R585	T3694	T3689	acl	involved,factors
R586	T3818	T3807	nummod	12,15
R587	T3819	T3807	punct	",",15
R588	T3820	T3807	nummod	13,15
R589	T3821	T3807	punct	",",15
R590	T3695	T3694	prep	in,involved
R591	T3822	T3807	nummod	14,15
R592	T3823	T3807	punct	",",15
R593	T3824	T3807	punct	],15
R594	T3825	T3785	punct	.,induced
R595	T3696	T3697	amod	cellular,metabolism
R596	T3827	T3828	det	These,observations
R597	T3828	T3830	nsubj	observations,suggest
R598	T3697	T3695	pobj	metabolism,in
R599	T3829	T3828	amod	latter,observations
R600	T3698	T3697	compound	energy,metabolism
R601	T3831	T3832	mark	that,involved
R602	T3832	T3830	ccomp	involved,suggest
R603	T3833	T3834	compound	PGC,1α
R604	T3699	T3700	punct	[,6
R605	T3834	T3832	nsubjpass	1α,involved
R606	T3835	T3834	punct	-,1α
R607	T3836	T3832	auxpass	is,involved
R608	T3837	T3832	prep	in,involved
R609	T3838	T3839	det	the,control
R610	T3700	T3681	parataxis	6,serves
R611	T3839	T3837	pobj	control,in
R612	T3840	T3839	amod	physiologic,control
R613	T3841	T3839	prep	of,control
R614	T3842	T3843	compound	energy,metabolism
R615	T3843	T3841	pobj	metabolism,of
R616	T3844	T3830	punct	.,suggest
R617	T3701	T3700	punct	],6
R618	T3702	T3681	punct	.,serves
R619	T3704	T3705	compound	PGC,1α
R620	T3846	T3847	amod	Several,lines
R621	T3847	T3848	nsubj	lines,indicate
R622	T3705	T3707	nsubj	1α,is
R623	T3849	T3847	prep	of,lines
R624	T3850	T3849	pobj	evidence,of
R625	T3851	T3847	punct	", ",lines
R626	T3706	T3705	punct	-,1α
R627	T3852	T3847	prep	based,lines
R628	T3853	T3852	prep	on,based
R629	T3854	T3855	det	the,results
R630	T3708	T3707	acomp	distinct,is
R631	T3855	T3853	pobj	results,on
R632	T3856	T3855	prep	of,results
R633	T3857	T3858	compound	overexpression,studies
R634	T3709	T3707	prep	among,is
R635	T3858	T3856	pobj	studies,of
R636	T3859	T3848	punct	", ",indicate
R637	T3860	T3861	mark	that,is
R638	T3710	T3711	amod	most,coactivators
R639	T3861	T3848	ccomp	is,indicate
R640	T3711	T3709	pobj	coactivators,among
R641	T3862	T3863	compound	PGC,1α
R642	T3863	T3861	nsubj	1α,is
R643	T3864	T3863	punct	-,1α
R644	T3712	T3713	mark	in,exhibits
R645	T3865	T3861	acomp	sufficient,is
R646	T3866	T3867	aux	to,promote
R647	T3867	T3861	advcl	promote,is
R648	T3713	T3707	advcl	exhibits,is
R649	T3868	T3869	amod	mitochondrial,biogenesis
R650	T3869	T3867	dobj	biogenesis,promote
R651	T3870	T3867	cc	and,promote
R652	T3714	T3713	mark	that,exhibits
R653	T3715	T3713	nsubj	it,exhibits
R654	T3871	T3867	conj	regulate,promote
R655	T3872	T3873	amod	mitochondrial,capacity
R656	T3716	T3717	det	a,pattern
R657	T3873	T3871	dobj	capacity,regulate
R658	T3874	T3873	amod	respiratory,capacity
R659	T3875	T3848	punct	.,indicate
R660	T3717	T3713	dobj	pattern,exhibits
R661	T3877	T3878	advmod	First,activates
R662	T3718	T3719	npadvmod	tissue,enriched
R663	T3879	T3878	punct	", ",activates
R664	T3880	T3881	compound	PGC,1α
R665	T3881	T3878	nsubj	1α,activates
R666	T3719	T3717	amod	enriched,pattern
R667	T3882	T3881	punct	-,1α
R668	T3883	T3884	det	the,transcription
R669	T3884	T3878	dobj	transcription,activates
R670	T3720	T3719	punct	-,enriched
R671	T3721	T3717	compound	expression,pattern
R672	T3885	T3884	prep	of,transcription
R673	T3722	T3713	cc	and,exhibits
R674	T3886	T3887	amod	mitochondrial,protein
R675	T3887	T3885	pobj	protein,of
R676	T3723	T3713	conj	is,exhibits
R677	T3888	T3887	compound	uncoupling,protein
R678	T3889	T3887	punct	-,protein
R679	T3890	T3887	nummod	1,protein
R680	T3724	T3725	advmod	highly,inducible
R681	T3891	T3887	punct	(,protein
R682	T3892	T3887	appos	UCP,protein
R683	T3725	T3723	acomp	inducible,is
R684	T3893	T3892	punct	-,UCP
R685	T3894	T3892	nummod	1,UCP
R686	T3895	T3878	punct	),activates
R687	T3896	T3878	prep	in,activates
R688	T3726	T3725	prep	by,inducible
R689	T3897	T3896	pobj	BAT,in
R690	T3898	T3878	prep	through,activates
R691	T3899	T3898	pobj	interactions,through
R692	T3727	T3728	amod	physiologic,conditions
R693	T3900	T3899	prep	with,interactions
R694	T3901	T3902	det	the,receptors
R695	T3902	T3900	pobj	receptors,with
R696	T3728	T3726	pobj	conditions,by
R697	T3903	T3902	amod	nuclear,receptors
R698	T3904	T3902	compound	hormone,receptors
R699	T3905	T3902	appos	PPARγ,receptors
R700	T3729	T3728	acl	known,conditions
R701	T3906	T3905	cc	and,PPARγ
R702	T3907	T3908	compound	thyroid,receptor
R703	T3730	T3731	aux	to,increase
R704	T3908	T3905	conj	receptor,PPARγ
R705	T3909	T3910	punct	[,2
R706	T3910	T3878	parataxis	2,activates
R707	T3911	T3910	punct	],2
R708	T3731	T3729	xcomp	increase,known
R709	T3912	T3878	punct	.,activates
R710	T3914	T3915	advmod	Second,demonstrated
R711	T3732	T3733	det	the,demand
R712	T3916	T3915	punct	", ",demonstrated
R713	T3917	T3918	amod	forced,studies
R714	T3733	T3731	dobj	demand,increase
R715	T3918	T3915	nsubj	studies,demonstrated
R716	T3919	T3918	compound	expression,studies
R717	T3920	T3918	prep	in,studies
R718	T3921	T3922	amod	adipogenic,lines
R719	T3922	T3920	pobj	lines,in
R720	T3923	T3921	cc	and,adipogenic
R721	T3734	T3733	prep	for,demand
R722	T3924	T3921	conj	myogenic,adipogenic
R723	T3925	T3922	amod	mammalian,lines
R724	T3926	T3922	compound	cell,lines
R725	T3927	T3928	mark	that,activates
R726	T3735	T3736	amod	mitochondrial,ATP
R727	T3928	T3915	ccomp	activates,demonstrated
R728	T3929	T3930	compound	PGC,1α
R729	T3930	T3928	nsubj	1α,activates
R730	T3736	T3734	pobj	ATP,for
R731	T3931	T3930	punct	-,1α
R732	T3932	T3933	amod	mitochondrial,biogenesis
R733	T3933	T3928	dobj	biogenesis,activates
R734	T3934	T3928	prep	through,activates
R735	T3737	T3736	cc	or,ATP
R736	T3935	T3936	det	a,group
R737	T3936	T3934	pobj	group,through
R738	T3937	T3936	prep	of,group
R739	T3738	T3739	compound	heat,production
R740	T3938	T3939	compound	transcription,targets
R741	T3939	T3937	pobj	targets,of
R742	T3940	T3939	compound	factor,targets
R743	T3739	T3736	conj	production,ATP
R744	T3941	T3936	prep	including,group
R745	T3942	T3943	amod	nuclear,factors
R746	T3943	T3941	pobj	factors,including
R747	T3951	T3950	punct	-,1
R748	T3944	T3943	amod	respiratory,factors
R749	T3945	T3943	appos	1,factors
R750	T3946	T3945	cc	and,1
R751	T3947	T3945	conj	2,1
R752	T3948	T3943	punct	(,factors
R753	T3949	T3950	nmod	NRF,1
R754	T3952	T3950	cc	and,1
R755	T3950	T3943	appos	1,factors
R756	T3953	T3954	punct	-,2
R757	T3954	T3950	conj	2,1
R758	T3955	T3943	punct	),factors
R759	T4057	T4056	punct	", ",indicate
R760	T3956	T3943	cc	and,factors
R761	T4058	T4059	det	these,results
R762	T4059	T4056	nsubj	results,indicate
R763	T4060	T4061	mark	that,is
R764	T3957	T3958	amod	mitochondrial,A
R765	T4061	T4056	ccomp	is,indicate
R766	T4062	T4063	compound	PGC,1α
R767	T4063	T4061	nsubj	1α,is
R768	T3958	T3943	conj	A,factors
R769	T4064	T4063	punct	-,1α
R770	T4065	T4061	acomp	sufficient,is
R771	T4066	T4067	aux	to,drive
R772	T4067	T4061	advcl	drive,is
R773	T4068	T4069	amod	mitochondrial,biogenesis
R774	T4069	T4067	dobj	biogenesis,drive
R775	T3959	T3958	compound	transcription,A
R776	T4070	T4056	punct	.,indicate
R777	T4072	T4073	amod	Recent,evidence
R778	T3960	T3958	compound	factor,A
R779	T4073	T4074	nsubj	evidence,implicates
R780	T4075	T4074	advmod	also,implicates
R781	T3961	T3958	punct	(,A
R782	T4076	T4077	compound	PGC,1α
R783	T4077	T4074	dobj	1α,implicates
R784	T4078	T4077	punct	-,1α
R785	T3962	T3958	appos	Tfam,A
R786	T4079	T4074	prep	in,implicates
R787	T4080	T4081	det	the,control
R788	T3963	T3943	punct	),factors
R789	T4081	T4079	pobj	control,in
R790	T4082	T4081	amod	homeostatic,control
R791	T4083	T4081	prep	of,control
R792	T3964	T3943	punct	", ",factors
R793	T4084	T4085	amod	systemic,metabolism
R794	T4085	T4083	pobj	metabolism,of
R795	T4086	T4085	compound	energy,metabolism
R796	T3965	T3966	amod	key,regulators
R797	T4087	T4074	punct	.,implicates
R798	T4089	T4090	compound	PGC,1α
R799	T3966	T3943	appos	regulators,factors
R800	T4090	T4092	nsubjpass	1α,shown
R801	T4091	T4090	punct	-,1α
R802	T3967	T3966	amod	transcriptional,regulators
R803	T4093	T4092	aux	has,shown
R804	T3968	T3966	prep	of,regulators
R805	T4094	T4092	auxpass	been,shown
R806	T4095	T4096	aux	to,regulate
R807	T4096	T4092	xcomp	regulate,shown
R808	T4097	T4098	amod	several,genes
R809	T3969	T3970	amod	mitochondrial,transcription
R810	T4098	T4096	dobj	genes,regulate
R811	T4099	T4098	amod	key,genes
R812	T4100	T4098	amod	hepatic,genes
R813	T3970	T3968	pobj	transcription,of
R814	T4101	T4098	amod	gluconeogenic,genes
R815	T4102	T4103	punct	[,21
R816	T3971	T3970	compound	DNA,transcription
R817	T4103	T4092	parataxis	21,shown
R818	T4104	T4103	nummod	18,21
R819	T4105	T4103	punct	",",21
R820	T3972	T3970	cc	and,transcription
R821	T4106	T4103	nummod	19,21
R822	T4107	T4103	punct	",",21
R823	T4108	T4103	nummod	20,21
R824	T4109	T4103	punct	",",21
R825	T4110	T4103	punct	],21
R826	T4111	T4092	punct	.,shown
R827	T3973	T3970	conj	replication,transcription
R828	T4113	T4114	amod	Recent,studies
R829	T4114	T4115	nsubj	studies,shown
R830	T3974	T3975	punct	[,8
R831	T4116	T4115	aux	have,shown
R832	T4117	T4115	advmod	also,shown
R833	T4118	T4119	amod	altered,expression
R834	T3975	T3966	parataxis	8,regulators
R835	T4119	T4115	dobj	expression,shown
R836	T4120	T4119	prep	of,expression
R837	T4121	T4122	nmod	PGC,1α
R838	T3976	T3975	punct	],8
R839	T4122	T4124	nmod	1α,pathways
R840	T4123	T4122	punct	-,1α
R841	T4124	T4120	pobj	pathways,of
R842	T3977	T3915	punct	.,demonstrated
R843	T4125	T4122	cc	and,1α
R844	T4126	T4127	amod	downstream,mitochondrial
R845	T4127	T4122	conj	mitochondrial,1α
R846	T3979	T3980	advmod	Third,demonstrated
R847	T4128	T4124	compound	target,pathways
R848	T4129	T4115	prep	in,shown
R849	T3981	T3980	punct	", ",demonstrated
R850	T4130	T4131	amod	skeletal,muscle
R851	T4131	T4129	pobj	muscle,in
R852	T3982	T3980	nsubj	studies,demonstrated
R853	T4132	T4131	prep	of,muscle
R854	T4133	T4132	pobj	humans,of
R855	T4134	T4133	prep	with,humans
R856	T3983	T3982	prep	in,studies
R857	T4135	T4136	compound	insulin,resistance
R858	T4136	T4134	pobj	resistance,with
R859	T3984	T3985	amod	primary,myocytes
R860	T4137	T4136	cc	and,resistance
R861	T4138	T4136	conj	diabetes,resistance
R862	T3985	T3983	pobj	myocytes,in
R863	T4139	T4140	punct	[,24
R864	T4140	T4115	parataxis	24,shown
R865	T4141	T4140	nummod	22,24
R866	T3986	T3985	amod	cardiac,myocytes
R867	T4142	T4140	punct	",",24
R868	T4143	T4140	nummod	23,24
R869	T4144	T4140	punct	",",24
R870	T3987	T3982	prep	in,studies
R871	T4145	T4140	punct	],24
R872	T4146	T4115	punct	.,shown
R873	T4148	T4149	prep	In,shown
R874	T3988	T3987	pobj	culture,in
R875	T4150	T4148	pobj	addition,In
R876	T4151	T4149	punct	", ",shown
R877	T4152	T4153	amod	single,nucleotide
R878	T4153	T4154	compound	nucleotide,polymorphisms
R879	T3989	T3987	cc	and,in
R880	T4154	T4149	nsubjpass	polymorphisms,shown
R881	T4155	T4154	prep	within,polymorphisms
R882	T4156	T4157	det	the,gene
R883	T3990	T3987	conj	in,in
R884	T4157	T4155	pobj	gene,within
R885	T4158	T4157	amod	human,gene
R886	T4159	T4160	compound	PGC,1α
R887	T4160	T4157	compound	1α,gene
R888	T3991	T3992	det	the,hearts
R889	T4161	T4160	punct	-,1α
R890	T3992	T3990	pobj	hearts,in
R891	T3993	T3992	prep	of,hearts
R892	T4162	T4149	aux	have,shown
R893	T3994	T3995	amod	transgenic,mice
R894	T4163	T4149	auxpass	been,shown
R895	T4164	T4165	aux	to,associated
R896	T4165	T4149	xcomp	associated,shown
R897	T3995	T3993	pobj	mice,of
R898	T4166	T4165	auxpass	be,associated
R899	T4167	T4165	prep	with,associated
R900	T4168	T4167	pobj	obesity,with
R901	T3996	T3980	aux	have,demonstrated
R902	T4169	T4168	punct	", ",obesity
R903	T4170	T4168	conj	hypertension,obesity
R904	T4171	T4170	punct	", ",hypertension
R905	T3997	T3998	mark	that,promotes
R906	T4172	T4170	cc	and,hypertension
R907	T4173	T4170	conj	diabetes,hypertension
R908	T3998	T3980	ccomp	promotes,demonstrated
R909	T4174	T4175	punct	[,30
R910	T4175	T4149	parataxis	30,shown
R911	T3999	T3998	nsubj	overexpression,promotes
R912	T4176	T4175	nummod	25,30
R913	T4177	T4175	punct	",",30
R914	T4178	T4175	nummod	26,30
R915	T4000	T3999	prep	of,overexpression
R916	T4179	T4175	punct	",",30
R917	T4180	T4175	nummod	27,30
R918	T4181	T4175	punct	",",30
R919	T4182	T4175	nummod	28,30
R920	T4001	T4002	compound	PGC,1α
R921	T4183	T4175	punct	",",30
R922	T4184	T4175	nummod	29,30
R923	T4185	T4175	punct	",",30
R924	T4002	T4000	pobj	1α,of
R925	T4186	T4175	punct	],30
R926	T4187	T4149	punct	.,shown
R927	T4189	T4190	det	The,studies
R928	T4190	T4196	nsubj	studies,provide
R929	T4191	T4190	nmod	gain,studies
R930	T4003	T4002	punct	-,1α
R931	T4192	T4191	punct	-,gain
R932	T4193	T4191	prep	of,gain
R933	T4194	T4193	punct	-,of
R934	T4004	T4005	amod	mitochondrial,biogenesis
R935	T4195	T4193	pobj	function,of
R936	T4197	T4190	acl	described,studies
R937	T4198	T4197	prep	to,described
R938	T4005	T3998	dobj	biogenesis,promotes
R939	T4199	T4198	pobj	date,to
R940	T4200	T4201	amod	compelling,evidence
R941	T4201	T4196	dobj	evidence,provide
R942	T4006	T4007	punct	[,16
R943	T4202	T4203	mark	that,is
R944	T4203	T4201	acl	is,evidence
R945	T4204	T4205	compound	PGC,1α
R946	T4007	T3980	parataxis	16,demonstrated
R947	T4205	T4203	nsubj	1α,is
R948	T4206	T4205	punct	-,1α
R949	T4207	T4203	acomp	capable,is
R950	T4008	T4007	nummod	10,16
R951	T4208	T4207	prep	of,capable
R952	T4209	T4208	pcomp	regulating,of
R953	T4210	T4211	amod	postnatal,metabolism
R954	T4009	T4007	punct	",",16
R955	T4211	T4209	dobj	metabolism,regulating
R956	T4212	T4211	compound	energy,metabolism
R957	T4213	T4196	punct	.,provide
R958	T4010	T4007	punct	],16
R959	T4215	T4216	advmod	However,addressed
R960	T4011	T3980	punct	.,demonstrated
R961	T4013	T4014	advmod	Lastly,triggers
R962	T4217	T4216	punct	", ",addressed
R963	T4218	T4219	det	the,necessity
R964	T4015	T4014	punct	", ",triggers
R965	T4219	T4216	nsubjpass	necessity,addressed
R966	T4220	T4219	prep	of,necessity
R967	T4221	T4222	compound	PGC,1α
R968	T4016	T4017	amod	forced,expression
R969	T4222	T4220	pobj	1α,of
R970	T4223	T4222	punct	-,1α
R971	T4224	T4219	prep	for,necessity
R972	T4017	T4014	nsubj	expression,triggers
R973	T4225	T4226	nmod	energy,homeostasis
R974	T4226	T4224	pobj	homeostasis,for
R975	T4018	T4017	prep	of,expression
R976	T4227	T4226	amod	metabolic,homeostasis
R977	T4228	T4226	punct	", ",homeostasis
R978	T4229	T4230	amod	mitochondrial,biogenesis
R979	T4230	T4226	conj	biogenesis,homeostasis
R980	T4231	T4230	punct	", ",biogenesis
R981	T4232	T4230	conj	development,biogenesis
R982	T4019	T4020	compound	PGC,1α
R983	T4233	T4232	punct	", ",development
R984	T4234	T4232	cc	and,development
R985	T4235	T4232	conj	growth,development
R986	T4020	T4018	pobj	1α,of
R987	T4236	T4216	aux	can,addressed
R988	T4237	T4216	advmod	only,addressed
R989	T4238	T4216	auxpass	be,addressed
R990	T4021	T4020	punct	-,1α
R991	T4239	T4216	advcl	using,addressed
R992	T4240	T4241	nmod	loss,strategies
R993	T4241	T4239	dobj	strategies,using
R994	T4022	T4017	prep	in,expression
R995	T4242	T4240	punct	-,loss
R996	T4243	T4240	prep	of,loss
R997	T4244	T4243	punct	-,of
R998	T4245	T4243	pobj	function,of
R999	T4023	T4024	amod	skeletal,muscle
R1000	T4246	T4216	punct	.,addressed
R1001	T4248	T4249	prep	To,established
R1002	T4024	T4022	pobj	muscle,in
R1003	T4250	T4251	det	this,end
R1004	T4251	T4248	pobj	end,To
R1005	T4025	T4024	prep	of,muscle
R1009	T4026	T4027	amod	transgenic,mice
R1010	T4255	T4249	cc	and,established
R1011	T4256	T4249	conj	characterized,established
R1012	T4257	T4256	dobj	mice,characterized
R1013	T4258	T4257	prep	with,mice
R1014	T4027	T4025	pobj	mice,of
R1015	T4259	T4260	amod	targeted,deletion
R1016	T4260	T4258	pobj	deletion,with
R1017	T4028	T4029	amod	mitochondrial,proliferation
R1018	T4261	T4260	prep	of,deletion
R1019	T4262	T4263	det	the,gene
R1021	T4029	T4014	dobj	proliferation,triggers
R1022	T4264	T4265	compound	PGC,1α
R1023	T4265	T4263	compound	1α,gene
R1024	T4266	T4265	punct	-,1α
R1025	T4030	T4029	cc	and,proliferation
R1026	T4267	T4249	punct	.,established
R1027	T4031	T4032	det	the,formation
R1028	T4032	T4029	conj	formation,proliferation
R1029	T4033	T4032	prep	of,formation
R1030	T4269	T4270	poss	Our,studies
R1031	T4270	T4271	nsubj	studies,demonstrate
R1032	T4272	T4270	prep	of,studies
R1033	T4273	T4274	nmod	PGC,1α
R1034	T4034	T4035	amod	mitochondrial,rich
R1035	T4274	T4276	nmod	1α,mice
R1036	T4035	T4037	amod	rich,fibers
R1037	T4036	T4035	punct	-,rich
R1038	T4275	T4274	punct	-,1α
R1039	T4037	T4033	pobj	fibers,of
R1040	T4276	T4272	pobj	mice,of
R1041	T4277	T4274	punct	−,1α
R1042	T4278	T4274	punct	/,1α
R1043	T4038	T4037	nmod	type,fibers
R1044	T4279	T4274	punct	−,1α
R1045	T4280	T4281	mark	that,required
R1046	T4039	T4038	nummod	I,type
R1047	T4281	T4271	ccomp	required,demonstrate
R1048	T4282	T4283	compound	PGC,1α
R1049	T4283	T4281	nsubjpass	1α,required
R1050	T4040	T4037	punct	", ",fibers
R1051	T4284	T4283	punct	-,1α
R1052	T4285	T4281	auxpass	is,required
R1053	T4286	T4281	neg	not,required
R1054	T4041	T4037	nmod	oxidative,fibers
R1055	T4287	T4281	advmod	absolutely,required
R1056	T4288	T4281	prep	for,required
R1057	T4289	T4290	amod	prenatal,viability
R1058	T4042	T4041	punct	(,oxidative
R1059	T4290	T4288	pobj	viability,for
R1060	T4291	T4290	prep	including,viability
R1061	T4292	T4293	amod	mitochondrial,biogenesis
R1062	T4043	T4041	punct	“,oxidative
R1063	T4293	T4291	pobj	biogenesis,including
R1064	T4294	T4271	punct	.,demonstrate
R1065	T4044	T4045	amod	slow,twitch
R1066	T4296	T4297	advmod	However,indicate
R1067	T4298	T4297	punct	", ",indicate
R1068	T4045	T4041	appos	twitch,oxidative
R1069	T4299	T4300	poss	our,findings
R1070	T4300	T4297	nsubj	findings,indicate
R1071	T4301	T4302	mark	that,serves
R1072	T4046	T4045	punct	-,twitch
R1073	T4047	T4037	punct	”,fibers
R1074	T4048	T4037	punct	),fibers
R1075	T4302	T4297	ccomp	serves,indicate
R1076	T4303	T4304	det	the,coactivator
R1077	T4049	T4037	compound	muscle,fibers
R1078	T4304	T4302	nsubj	coactivator,serves
R1079	T4305	T4306	compound	PGC,1α
R1080	T4306	T4304	appos	1α,coactivator
R1081	T4050	T4051	punct	[,17
R1082	T4307	T4306	punct	-,1α
R1083	T4308	T4309	det	a,role
R1084	T4309	T4302	dobj	role,serves
R1085	T4310	T4309	amod	critical,role
R1086	T4311	T4309	prep	in,role
R1087	T4051	T4014	parataxis	17,triggers
R1088	T4312	T4313	det	the,function
R1089	T4313	T4311	pobj	function,in
R1090	T4314	T4313	amod	normal,function
R1091	T4052	T4051	punct	],17
R1092	T4315	T4313	amod	metabolic,function
R1093	T4316	T4313	prep	of,function
R1094	T4317	T4318	amod	multiple,organs
R1095	T4053	T4014	punct	.,triggers
R1096	T4318	T4316	pobj	organs,of
R1097	T4319	T4311	cc	and,in
R1098	T4320	T4311	conj	for,in
R1099	T4055	T4056	advmod	Collectively,indicate
R1100	T4321	T4322	amod	appropriate,adaptation
R1101	T4322	T4320	pobj	adaptation,for
R1102	T4323	T4322	prep	to,adaptation
R1103	T4324	T4325	amod	physiologic,stress
R1104	T4325	T4323	pobj	stress,to
R1105	T4326	T4309	prep	during,role
R1106	T4327	T4328	amod	postnatal,life
R1107	T4328	T4326	pobj	life,during
R1108	T4329	T4297	punct	.,indicate
R1117	T5682	T5681	prep	of,Disruption
R1118	T5683	T5684	det	the,Gene
R1119	T5684	T5682	pobj	Gene,of
R1120	T5685	T5686	compound	PGC,1α
R1121	T5686	T5684	compound	1α,Gene
R1122	T5687	T5686	punct	-,1α
R1123	T5688	T5681	prep	in,Disruption
R1124	T5689	T5688	pobj	Mice,in
R1125	T5691	T5692	det	A,vector
R1126	T5692	T5698	nsubjpass	vector,generated
R1127	T5693	T5694	npadvmod	neomycin,based
R1128	T5694	T5692	amod	based,vector
R1129	T5695	T5694	punct	-,based
R1130	T5696	T5692	compound	gene,vector
R1131	T5697	T5692	compound	targeting,vector
R1132	T5699	T5698	auxpass	was,generated
R1133	T5700	T5701	aux	to,delete
R1134	T5701	T5698	advcl	delete,generated
R1135	T5702	T5703	nmod	exons,4
R1136	T5703	T5701	dobj	4,delete
R1137	T5704	T5703	cc	and,4
R1138	T5705	T5703	conj	5,4
R1139	T5706	T5703	prep	of,4
R1140	T5707	T5708	det	the,gene
R1141	T5708	T5706	pobj	gene,of
R1142	T5709	T5708	amod	murine,gene
R1143	T5710	T5711	compound	PGC,1α
R1144	T5711	T5708	compound	1α,gene
R1145	T5712	T5711	punct	-,1α
R1146	T5713	T5698	punct	.,generated
R1147	T5715	T5716	det	The,event
R1148	T5716	T5718	nsubj	event,resulted
R1149	T5717	T5716	compound	targeting,event
R1150	T5719	T5718	prep	in,resulted
R1151	T5720	T5721	det	a,recombination
R1152	T5721	T5719	pobj	recombination,in
R1153	T5722	T5721	nummod	3,recombination
R1154	T5723	T5722	punct	′,3
R1155	T5724	T5721	amod	homologous,recombination
R1156	T5725	T5718	prep	with,resulted
R1157	T5726	T5725	pobj	insertion,with
R1158	T5727	T5726	prep	of,insertion
R1159	T5728	T5729	det	the,remainder
R1160	T5729	T5727	pobj	remainder,of
R1161	T5730	T5729	prep	of,remainder
R1162	T5731	T5732	det	the,construct
R1163	T5732	T5730	pobj	construct,of
R1164	T5733	T5734	punct	(,1A
R1165	T5734	T5718	parataxis	1A,resulted
R1166	T5735	T5734	compound	Figure,1A
R1167	T5736	T5734	punct	),1A
R1168	T5737	T5718	punct	.,resulted
R1169	T5739	T5740	det	The,event
R1170	T5740	T5744	nsubjpass	event,confirmed
R1171	T5741	T5742	compound	insertion,recombination
R1172	T5742	T5740	compound	recombination,event
R1173	T5743	T5742	punct	/,recombination
R1174	T5745	T5744	auxpass	was,confirmed
R1175	T5746	T5744	prep	by,confirmed
R1176	T5747	T5748	compound	Southern,blotting
R1177	T5748	T5746	pobj	blotting,by
R1178	T5749	T5748	cc	and,blotting
R1179	T5750	T5751	compound	DNA,sequencing
R1180	T5751	T5748	conj	sequencing,blotting
R1181	T5752	T5744	punct	.,confirmed
R1182	T5754	T5755	det	The,insertion
R1183	T5755	T5756	nsubj	insertion,caused
R1184	T5757	T5758	det	an,duplication
R1185	T5758	T5756	dobj	duplication,caused
R1186	T5759	T5758	nmod	exon,duplication
R1187	T5760	T5759	nummod	3,exon
R1188	T5761	T5758	prep	between,duplication
R1189	T5762	T5763	nmod	exons,5
R1190	T5763	T5761	pobj	5,between
R1191	T5764	T5763	cc	and,5
R1192	T5765	T5763	conj	6,5
R1193	T5766	T5767	dep	that,creates
R1194	T5767	T5758	relcl	creates,duplication
R1195	T5768	T5769	det	a,frameshift
R1196	T5769	T5767	dobj	frameshift,creates
R1197	T5770	T5771	amod	coding,region
R1198	T5771	T5769	compound	region,frameshift
R1199	T5772	T5767	advcl	resulting,creates
R1200	T5773	T5772	prep	in,resulting
R1201	T5774	T5775	det	a,termination
R1202	T5775	T5773	pobj	termination,in
R1203	T5776	T5775	amod	premature,termination
R1204	T5777	T5775	prep	at,termination
R1205	T5778	T5779	compound	amino,acid
R1206	T5779	T5777	pobj	acid,at
R1207	T5780	T5779	nummod	255,acid
R1208	T5781	T5756	punct	.,caused
R1209	T5783	T5784	compound	Germline,transmission
R1210	T5784	T5785	nsubjpass	transmission,confirmed
R1211	T5786	T5784	prep	of,transmission
R1212	T5787	T5788	det	the,allele
R1213	T5788	T5786	pobj	allele,of
R1214	T5789	T5788	compound	mutant,allele
R1215	T5790	T5785	auxpass	was,confirmed
R1216	T5791	T5785	advcl	using,confirmed
R1217	T5792	T5793	compound	Southern,blotting
R1218	T5793	T5791	dobj	blotting,using
R1219	T5794	T5795	punct	(,1B
R1220	T5795	T5793	parataxis	1B,blotting
R1221	T5796	T5795	compound	Figure,1B
R1222	T5797	T5795	punct	),1B
R1223	T5798	T5793	cc	and,blotting
R1224	T5799	T5793	conj	PCR,blotting
R1225	T5800	T5801	punct	(,data
R1226	T5801	T5799	meta	data,PCR
R1227	T5802	T5801	amod	unpublished,data
R1228	T5803	T5801	punct	),data
R1229	T5804	T5785	punct	.,confirmed
R1230	T5806	T5807	det	The,disruption
R1231	T5807	T5812	nsubj	disruption,resulted
R1232	T5808	T5809	compound	PGC,1α
R1233	T5809	T5807	compound	1α,disruption
R1234	T5810	T5809	punct	-,1α
R1235	T5811	T5807	compound	gene,disruption
R1236	T5813	T5812	prep	in,resulted
R1237	T5814	T5815	det	an,transcript
R1238	T5815	T5813	pobj	transcript,in
R1239	T5816	T5815	amod	unstable,transcript
R1240	T5817	T5818	dep	that,detected
R1241	T5818	T5815	relcl	detected,transcript
R1242	T5819	T5818	aux	could,detected
R1243	T5820	T5818	neg	not,detected
R1244	T5821	T5818	auxpass	be,detected
R1245	T5822	T5818	prep	by,detected
R1246	T5823	T5824	compound	RNA,analysis
R1247	T5824	T5822	pobj	analysis,by
R1248	T5825	T5824	compound	blot,analysis
R1249	T5826	T5818	prep	in,detected
R1250	T5827	T5826	pobj	heart,in
R1251	T5828	T5827	cc	and,heart
R1252	T5829	T5830	amod	other,tissues
R1253	T5830	T5827	conj	tissues,heart
R1254	T5831	T5818	prep	in,detected
R1255	T5832	T5833	nmod	PGC,1α
R1256	T5833	T5835	nmod	1α,mice
R1257	T5834	T5833	punct	-,1α
R1258	T5835	T5831	pobj	mice,in
R1259	T5836	T5833	punct	−,1α
R1260	T5837	T5833	punct	/,1α
R1261	T5838	T5833	punct	−,1α
R1262	T5839	T5840	punct	(,1C
R1263	T5840	T5812	parataxis	1C,resulted
R1264	T5841	T5840	compound	Figure,1C
R1265	T5842	T5840	cc	and,1C
R1266	T5843	T5844	amod	unpublished,data
R1267	T5844	T5840	conj	data,1C
R1268	T5845	T5840	punct	),1C
R1269	T5846	T5812	punct	.,resulted
R1270	T5848	T5849	amod	Quantitative,PCR
R1271	T5849	T5852	nsubjpass	PCR,utilized
R1272	T5850	T5849	compound	RT,PCR
R1273	T5851	T5849	punct	-,PCR
R1274	T5853	T5852	auxpass	was,utilized
R1275	T5854	T5855	aux	to,evaluate
R1276	T5855	T5852	advcl	evaluate,utilized
R1277	T5856	T5855	advmod	further,evaluate
R1278	T5857	T5858	det	the,efficacy
R1279	T5858	T5855	dobj	efficacy,evaluate
R1280	T5859	T5858	prep	of,efficacy
R1281	T5860	T5861	det	the,targeting
R1282	T5861	T5859	pobj	targeting,of
R1283	T5862	T5861	compound	gene,targeting
R1284	T5863	T5852	punct	.,utilized
R1285	T5865	T5866	prep	For,designed
R1286	T5867	T5868	det	these,studies
R1287	T5868	T5865	pobj	studies,For
R1288	T5869	T5866	punct	", ",designed
R1289	T5870	T5871	compound	PCR,primers
R1290	T5871	T5866	nsubjpass	primers,designed
R1291	T5872	T5866	auxpass	were,designed
R1292	T5873	T5874	aux	to,amplify
R1293	T5874	T5866	advcl	amplify,designed
R1294	T5875	T5876	det	a,region
R1295	T5876	T5874	dobj	region,amplify
R1296	T5877	T5876	prep	of,region
R1297	T5878	T5879	det	the,transcript
R1298	T5879	T5877	pobj	transcript,of
R1299	T5880	T5881	compound	PGC,1α
R1300	T5881	T5879	compound	1α,transcript
R1301	T5882	T5881	punct	-,1α
R1302	T5883	T5879	compound	gene,transcript
R1303	T5884	T5876	acl	containing,region
R1304	T5885	T5886	det	the,border
R1305	T5886	T5884	dobj	border,containing
R1306	T5887	T5888	nmod	exon,5
R1307	T5888	T5886	nummod	5,border
R1308	T5889	T5890	punct	–,6
R1309	T5890	T5888	prep	6,5
R1310	T5891	T5886	punct	(,border
R1311	T5892	T5886	acl	predicted,border
R1312	T5893	T5894	aux	to,be
R1313	T5894	T5892	xcomp	be,predicted
R1314	T5895	T5894	acomp	absent,be
R1315	T5896	T5894	prep	in,be
R1316	T5897	T5898	nmod	PGC,1α
R1317	T5898	T5900	nmod	1α,mice
R1318	T5899	T5898	punct	-,1α
R1319	T5900	T5896	pobj	mice,in
R1320	T5901	T5898	punct	−,1α
R1321	T5902	T5898	punct	/,1α
R1322	T5903	T5898	punct	−,1α
R1323	T5904	T5886	punct	),border
R1324	T5905	T5886	cc	or,border
R1325	T5906	T5907	det	the,border
R1326	T5907	T5886	conj	border,border
R1327	T5908	T5909	nmod	exon,5
R1328	T5909	T5907	nummod	5,border
R1329	T5910	T5911	punct	–,3
R1330	T5911	T5909	prep	3,5
R1331	T5912	T5907	punct	(,border
R1332	T5913	T5907	acl	predicted,border
R1333	T5914	T5915	aux	to,be
R1334	T5915	T5913	xcomp	be,predicted
R1335	T5916	T5915	acomp	present,be
R1336	T5917	T5918	advmod	only,in
R1337	T5918	T5915	prep	in,be
R1338	T5919	T5920	det	the,mice
R1339	T5920	T5918	pobj	mice,in
R1340	T5921	T5922	nmod	PGC,1α
R1341	T5922	T5920	nmod	1α,mice
R1342	T5923	T5922	punct	-,1α
R1343	T5924	T5922	punct	−,1α
R1344	T5925	T5922	punct	/,1α
R1345	T5926	T5922	punct	−,1α
R1346	T5927	T5907	punct	),border
R1347	T5928	T5866	punct	.,designed
R1348	T5930	T5931	det	The,amplicon
R1349	T5931	T5936	nsubjpass	amplicon,detected
R1350	T5932	T5933	nmod	exon,5
R1351	T5933	T5931	nummod	5,amplicon
R1352	T5934	T5935	punct	–,6
R1353	T5935	T5933	prep	6,5
R1354	T5937	T5936	auxpass	was,detected
R1355	T5938	T5936	prep	in,detected
R1356	T5939	T5938	pobj	heart,in
R1357	T5940	T5939	cc	and,heart
R1358	T5941	T5939	conj	BAT,heart
R1359	T5942	T5939	prep	of,heart
R1360	T5943	T5944	amod	wild,type
R1361	T5944	T5946	nmod	type,mice
R1362	T5945	T5944	punct	-,type
R1363	T5946	T5942	pobj	mice,of
R1364	T5947	T5944	punct	(,type
R1365	T5948	T5944	appos	WT,type
R1366	T5949	T5944	punct	),type
R1367	T5950	T5944	cc	but,type
R1368	T5951	T5950	neg	not,but
R1369	T5952	T5953	compound	PGC,1α
R1370	T5953	T5944	conj	1α,type
R1371	T5954	T5953	punct	-,1α
R1372	T5955	T5953	punct	−,1α
R1373	T5956	T5953	punct	/,1α
R1374	T5957	T5953	punct	−,1α
R1375	T5958	T5959	punct	(,1D
R1376	T5959	T5936	parataxis	1D,detected
R1377	T5960	T5959	compound	Figure,1D
R1378	T5961	T5959	punct	),1D
R1379	T5962	T5936	punct	.,detected
R1380	T5964	T5965	advmod	Conversely,was
R1381	T5966	T5965	punct	", ",was
R1382	T5967	T5968	det	the,product
R1383	T5968	T5965	nsubj	product,was
R1384	T5969	T5970	nmod	exon,5
R1385	T5970	T5968	nummod	5,product
R1386	T5971	T5972	punct	–,3
R1387	T5972	T5970	prep	3,5
R1388	T5973	T5965	acomp	present,was
R1389	T5974	T5975	advmod	only,in
R1390	T5975	T5965	prep	in,was
R1391	T5976	T5977	nmod	PGC,1α
R1392	T5977	T5979	nmod	1α,mice
R1393	T5978	T5977	punct	-,1α
R1394	T5979	T5975	pobj	mice,in
R1395	T5980	T5977	punct	−,1α
R1396	T5981	T5977	punct	/,1α
R1397	T5982	T5977	punct	−,1α
R1398	T5983	T5984	punct	(,1D
R1399	T5984	T5965	parataxis	1D,was
R1400	T5985	T5984	compound	Figure,1D
R1401	T5986	T5984	punct	),1D
R1402	T5987	T5965	punct	.,was
R1403	T5989	T5990	det	An,amplicon
R1404	T5990	T5996	nsubjpass	amplicon,detected
R1405	T5991	T5992	nmod	exon,10
R1406	T5992	T5990	nummod	10,amplicon
R1407	T5993	T5994	punct	–,11
R1408	T5994	T5992	prep	11,10
R1409	T5995	T5990	compound	border,amplicon
R1410	T5997	T5990	punct	(,amplicon
R1411	T5998	T5990	acl	predicted,amplicon
R1412	T5999	T6000	aux	to,be
R1413	T6105	T6104	punct	-,1α
R1414	T6107	T6106	auxpass	were,detected
R1415	T6108	T6106	advmod	also,detected
R1416	T6109	T6106	neg	not,detected
R1417	T6110	T6106	prep	by,detected
R1418	T6111	T6112	compound	Western,blot
R1419	T6112	T6113	compound	blot,analysis
R1420	T6113	T6110	pobj	analysis,by
R1421	T6114	T6115	punct	(,data
R1422	T6115	T6106	meta	data,detected
R1423	T6116	T6115	amod	unpublished,data
R1424	T6117	T6115	punct	),data
R1425	T6118	T6106	punct	.,detected
R1426	T6120	T6121	advmod	Lastly,altered
R1427	T6000	T5998	xcomp	be,predicted
R1428	T6122	T6121	punct	", ",altered
R1429	T6001	T6000	acomp	present,be
R1430	T6002	T6000	prep	in,be
R1431	T6003	T6004	det	both,genotypes
R1432	T6123	T6121	nsubjpass	expression,altered
R1433	T6004	T6002	pobj	genotypes,in
R1434	T6005	T5996	punct	),detected
R1435	T6006	T5996	auxpass	was,detected
R1436	T6007	T5996	prep	in,detected
R1437	T6008	T6009	nmod	WT,mice
R1438	T6124	T6123	prep	of,expression
R1439	T6009	T6007	pobj	mice,in
R1440	T6010	T6008	cc	and,WT
R1441	T6011	T6012	compound	PGC,1α
R1442	T6125	T6126	det	the,genes
R1443	T6012	T6008	conj	1α,WT
R1444	T6013	T6012	punct	-,1α
R1445	T6014	T6012	punct	−,1α
R1446	T6126	T6124	pobj	genes,of
R1447	T6015	T6012	punct	/,1α
R1448	T6016	T6012	punct	−,1α
R1449	T6017	T5996	punct	", ",detected
R1450	T6127	T6126	acl	encoding,genes
R1451	T6018	T5996	cc	but,detected
R1452	T6019	T6020	auxpass	was,diminished
R1453	T6020	T5996	conj	diminished,detected
R1454	T6128	T6129	det	the,members
R1455	T6021	T6020	advmod	greatly,diminished
R1456	T6022	T6020	prep	in,diminished
R1457	T6023	T6024	det	the,mice
R1458	T6129	T6127	dobj	members,encoding
R1459	T6024	T6022	pobj	mice,in
R1460	T6025	T6026	nmod	PGC,1α
R1461	T6130	T6129	amod	other,members
R1462	T6026	T6024	nmod	1α,mice
R1463	T6027	T6026	punct	-,1α
R1464	T6028	T6026	punct	−,1α
R1465	T6131	T6129	amod	known,members
R1466	T6029	T6026	punct	/,1α
R1467	T6132	T6129	nmod	PGC,members
R1468	T6030	T6026	punct	−,1α
R1469	T6031	T6020	punct	", ",diminished
R1470	T6032	T6020	advcl	indicating,diminished
R1471	T6033	T6034	mark	that,is
R1472	T6133	T6132	punct	-,PGC
R1473	T6134	T6132	nummod	1,PGC
R1474	T6034	T6032	ccomp	is,indicating
R1475	T6035	T6036	det	the,transcript
R1476	T6135	T6129	compound	family,members
R1477	T6036	T6034	nsubj	transcript,is
R1478	T6037	T6036	compound	mutant,transcript
R1479	T6038	T6034	acomp	unstable,is
R1480	T6136	T6129	punct	", ",members
R1481	T6039	T5996	punct	.,detected
R1482	T6137	T6138	compound	PGC,1β
R1483	T6041	T6042	compound	PGC,1α
R1484	T6042	T6044	compound	1α,protein
R1485	T6043	T6042	punct	-,1α
R1486	T6138	T6129	appos	1β,members
R1487	T6044	T6045	nsubjpass	protein,detected
R1488	T6046	T6045	auxpass	was,detected
R1489	T6139	T6138	punct	-,1β
R1490	T6047	T6045	neg	not,detected
R1491	T6048	T6045	prep	in,detected
R1492	T6140	T6138	cc	and,1β
R1493	T6049	T6050	amod	whole,cell
R1494	T6050	T6051	nmod	cell,extracts
R1495	T6051	T6048	pobj	extracts,in
R1496	T6141	T6138	conj	PRC,1β
R1497	T6052	T6053	punct	(,1E
R1498	T6053	T6050	parataxis	1E,cell
R1499	T6142	T6121	punct	", ",altered
R1500	T6054	T6053	compound	Figure,1E
R1501	T6055	T6053	punct	),1E
R1502	T6056	T6050	cc	or,cell
R1503	T6143	T6121	auxpass	was,altered
R1504	T6057	T6058	amod	nuclear,protein
R1505	T6058	T6050	conj	protein,cell
R1506	T6059	T6060	punct	(,data
R1507	T6144	T6121	neg	not,altered
R1508	T6060	T6051	meta	data,extracts
R1509	T6061	T6060	amod	unpublished,data
R1510	T6145	T6121	advmod	significantly,altered
R1511	T6062	T6060	punct	),data
R1512	T6063	T6051	acl	isolated,extracts
R1513	T6146	T6121	prep	in,altered
R1514	T6064	T6063	prep	from,isolated
R1515	T6065	T6064	pobj	BAT,from
R1516	T6066	T6065	prep	of,BAT
R1518	T6067	T6068	nmod	PGC,1α
R1519	T6068	T6070	nmod	1α,mice
R1520	T6148	T6147	prep	of,heart
R1521	T6069	T6068	punct	-,1α
R1522	T6070	T6066	pobj	mice,of
R1523	T6071	T6068	punct	−,1α
R1524	T6072	T6068	punct	/,1α
R1525	T6073	T6068	punct	−,1α
R1526	T6149	T6150	nmod	PGC,1α
R1527	T6074	T6063	prep	under,isolated
R1528	T6075	T6076	amod	basal,conditions
R1529	T6076	T6074	pobj	conditions,under
R1530	T6150	T6152	nmod	1α,mice
R1531	T6077	T6045	cc	or,detected
R1532	T6078	T6045	conj	in,detected
R1533	T6079	T6078	pobj	response,in
R1534	T6151	T6150	punct	-,1α
R1535	T6080	T6079	prep	to,response
R1536	T6081	T6082	compound	cold,exposure
R1537	T6082	T6080	pobj	exposure,to
R1538	T6152	T6148	pobj	mice,of
R1539	T6083	T6082	punct	", ",exposure
R1540	T6084	T6085	det	a,condition
R1541	T6085	T6082	appos	condition,exposure
R1542	T6153	T6150	punct	−,1α
R1543	T6086	T6085	acl	known,condition
R1544	T6087	T6088	aux	to,induce
R1545	T6154	T6150	punct	/,1α
R1546	T6088	T6086	xcomp	induce,known
R1547	T6089	T6088	advmod	markedly,induce
R1548	T6155	T6150	punct	−,1α
R1549	T6090	T6091	det	the,expression
R1550	T6091	T6088	dobj	expression,induce
R1551	T6092	T6091	prep	of,expression
R1552	T6156	T6157	punct	(,1C
R1553	T6093	T6094	compound	PGC,1α
R1554	T6094	T6092	pobj	1α,of
R1555	T6095	T6094	punct	-,1α
R1556	T6096	T6088	prep	in,induce
R1557	T6157	T6121	parataxis	1C,altered
R1558	T6097	T6096	pobj	BAT,in
R1559	T6098	T6045	punct	.,detected
R1560	T6158	T6157	compound	Figure,1C
R1561	T6100	T6101	amod	Smaller,proteins
R1562	T6101	T6106	nsubjpass	proteins,detected
R1563	T6102	T6101	compound	mutant,proteins
R1564	T6103	T6104	compound	PGC,1α
R1565	T6159	T6157	punct	),1C
R1566	T6104	T6101	compound	1α,proteins
R1567	T6160	T6121	punct	.,altered
R1568	T6162	T6163	advcl	Taken,support
R1569	T6164	T6162	advmod	together,Taken
R1570	T6165	T6163	punct	", ",support
R1571	T6166	T6167	det	these,results
R1572	T6167	T6163	nsubj	results,support
R1573	T6168	T6169	det	the,conclusion
R1574	T6169	T6163	dobj	conclusion,support
R1575	T6170	T6171	mark	that,resulted
R1576	T6171	T6169	acl	resulted,conclusion
R1577	T6172	T6173	det	the,event
R1578	T6173	T6171	nsubj	event,resulted
R1579	T6174	T6173	nmod	gene,event
R1580	T6175	T6174	amod	targeting,gene
R1581	T6176	T6171	prep	in,resulted
R1582	T6177	T6178	det	a,allele
R1583	T6178	T6176	pobj	allele,in
R1584	T6179	T6180	compound	PGC,1α
R1585	T6180	T6182	npadvmod	1α,null
R1586	T6181	T6180	punct	-,1α
R1587	T6182	T6178	amod	null,allele
R1588	T6183	T6163	punct	.,support
R1589	T7689	T7690	amod	General,Characteristics
R1590	T7691	T7690	prep	of,Characteristics
R1591	T7692	T7693	det	the,Mice
R1592	T7693	T7691	pobj	Mice,of
R1593	T7694	T7695	nmod	PGC,1α
R1594	T7695	T7693	nmod	1α,Mice
R1595	T7696	T7695	punct	-,1α
R1596	T7697	T7695	punct	−,1α
R1597	T7698	T7695	punct	/,1α
R1598	T7699	T7695	punct	−,1α
R1599	T7700	T7690	punct	: ,Characteristics
R1600	T7701	T7702	npadvmod	Age,Dependent
R1601	T7702	T7707	amod	Dependent,Obesity
R1602	T7703	T7701	punct	-,Age
R1603	T7704	T7701	cc	and,Age
R1604	T7705	T7701	conj	Sex,Age
R1605	T7706	T7702	punct	-,Dependent
R1606	T7707	T7690	appos	Obesity,Characteristics
R1607	T7709	T7710	amod	Heterozygous,mice
R1608	T7710	T7719	nsubjpass	mice,bred
R1609	T7711	T7710	punct	(,mice
R1610	T7712	T7713	nmod	PGC,1α
R1611	T7713	T7710	nmod	1α,mice
R1612	T7714	T7713	punct	-,1α
R1613	T7715	T7713	punct	+,1α
R1614	T7716	T7713	punct	/,1α
R1615	T7717	T7713	punct	−,1α
R1616	T7718	T7710	punct	),mice
R1617	T7720	T7719	auxpass	were,bred
R1618	T7721	T7722	aux	to,generate
R1619	T7722	T7719	advcl	generate,bred
R1620	T7723	T7724	nmod	PGC,1α
R1621	T7724	T7726	nmod	1α,offspring
R1622	T7725	T7724	punct	-,1α
R1623	T7726	T7722	dobj	offspring,generate
R1624	T7727	T7724	punct	−,1α
R1625	T7728	T7724	punct	/,1α
R1626	T7729	T7724	punct	−,1α
R1627	T7730	T7719	punct	.,bred
R1628	T7732	T7733	det	The,ratios
R1629	T7733	T7736	nsubj	ratios,were
R1630	T7734	T7733	amod	observed,ratios
R1631	T7735	T7733	compound	genotype,ratios
R1632	T7737	T7733	prep	of,ratios
R1633	T7738	T7739	det	the,offspring
R1634	T7739	T7737	pobj	offspring,of
R1635	T7740	T7736	acomp	consistent,were
R1636	T7741	T7740	prep	with,consistent
R1637	T7742	T7743	det	the,ratios
R1638	T7743	T7741	pobj	ratios,with
R1639	T7744	T7743	amod	expected,ratios
R1640	T7745	T7743	amod	Mendelian,ratios
R1641	T7746	T7747	punct	(,data
R1642	T7747	T7736	meta	data,were
R1643	T7748	T7747	amod	unpublished,data
R1644	T7749	T7747	punct	),data
R1645	T7750	T7736	punct	.,were
R1646	T7752	T7753	amod	Unexpected,deaths
R1647	T7753	T7754	nsubjpass	deaths,observed
R1648	T7755	T7753	prep	of,deaths
R1649	T7756	T7757	det	the,offspring
R1650	T7757	T7755	pobj	offspring,of
R1651	T7758	T7754	auxpass	were,observed
R1652	T7759	T7754	neg	not,observed
R1653	T7760	T7754	punct	", ",observed
R1654	T7761	T7754	cc	and,observed
R1655	T7762	T7763	nmod	PGC,1α
R1656	T7763	T7765	nmod	1α,offspring
R1657	T7764	T7763	punct	-,1α
R1658	T7765	T7776	nsubj	offspring,appeared
R1659	T7766	T7763	punct	+,1α
R1660	T7767	T7763	punct	/,1α
R1661	T7768	T7763	punct	−,1α
R1662	T7769	T7763	cc	and,1α
R1663	T7770	T7771	compound	PGC,1α
R1664	T7771	T7763	conj	1α,1α
R1665	T7772	T7771	punct	-,1α
R1666	T7773	T7771	punct	−,1α
R1667	T7774	T7771	punct	/,1α
R1668	T7775	T7771	punct	−,1α
R1669	T7776	T7754	conj	appeared,observed
R1670	T7777	T7776	oprd	normal,appeared
R1671	T7778	T7776	punct	.,appeared
R1672	T7780	T7781	amod	Total,weights
R1673	T7781	T7783	nsubj	weights,revealed
R1674	T7782	T7781	compound	body,weights
R1675	T7784	T7781	acl	obtained,weights
R1676	T7785	T7786	nummod	1,wk
R1677	T7786	T7787	npadvmod	wk,after
R1678	T7787	T7784	prep	after,obtained
R1679	T7788	T7787	pobj	birth,after
R1680	T7789	T7790	det	a,reduction
R1681	T7790	T7783	dobj	reduction,revealed
R1682	T7791	T7792	nummod	15,%
R1683	T7792	T7790	nmod	%,reduction
R1684	T7793	T7794	punct	–,%
R1685	T7794	T7792	prep	%,%
R1686	T7795	T7794	nummod	20,%
R1687	T7796	T7790	prep	in,reduction
R1688	T7797	T7798	amod	total,mass
R1689	T7798	T7796	pobj	mass,in
R1690	T7799	T7798	compound	body,mass
R1691	T7800	T7783	prep	for,revealed
R1692	T7801	T7802	amod	male,mice
R1693	T7802	T7800	pobj	mice,for
R1694	T7803	T7801	cc	and,male
R1695	T7804	T7801	conj	female,male
R1696	T7805	T7806	nmod	PGC,1α
R1697	T7806	T7802	nmod	1α,mice
R1698	T7807	T7806	punct	-,1α
R1699	T7808	T7806	punct	−,1α
R1700	T7809	T7806	punct	/,1α
R1701	T7810	T7806	punct	−,1α
R1702	T7811	T7783	advcl	relative,revealed
R1703	T7812	T7811	prep	to,relative
R1704	T7813	T7814	npadvmod	sex,matched
R1705	T7814	T7816	amod	matched,littermates
R1706	T7815	T7814	punct	-,matched
R1707	T7816	T7812	pobj	littermates,to
R1708	T7817	T7818	nmod	PGC,1α
R1709	T7818	T7816	nmod	1α,littermates
R1710	T7819	T7818	punct	-,1α
R1711	T7820	T7818	punct	+,1α
R1712	T7821	T7818	punct	/,1α
R1713	T7822	T7818	punct	+,1α
R1714	T7823	T7824	punct	(,Figure
R1715	T7824	T7783	parataxis	Figure,revealed
R1716	T7825	T7824	nummod	2,Figure
R1717	T7826	T7824	punct	),Figure
R1718	T7827	T7783	punct	.,revealed
R1719	T7829	T7830	det	The,decrement
R1720	T7830	T7832	nsubj	decrement,disappeared
R1721	T7831	T7830	compound	weight,decrement
R1722	T7833	T7830	prep	between,decrement
R1723	T7834	T7835	nmod	PGC,1α
R1724	T7835	T7837	nmod	1α,littermates
R1725	T7836	T7835	punct	-,1α
R1726	T7837	T7833	pobj	littermates,between
R1727	T7838	T7835	punct	−,1α
R1728	T7839	T7835	punct	/,1α
R1729	T7840	T7835	punct	−,1α
R1730	T7841	T7835	cc	and,1α
R1731	T7842	T7843	compound	PGC,1α
R1732	T7843	T7835	conj	1α,1α
R1733	T7844	T7843	punct	-,1α
R1734	T7845	T7843	punct	+,1α
R1735	T7846	T7843	punct	/,1α
R1736	T7847	T7843	punct	+,1α
R1737	T7848	T7832	prep	by,disappeared
R1738	T7849	T7850	nummod	3,wk
R1739	T7850	T7848	pobj	wk,by
R1740	T7851	T7850	prep	of,wk
R1741	T7852	T7851	pobj	age,of
R1742	T7853	T7854	punct	(,2A
R1743	T7854	T7832	parataxis	2A,disappeared
R1744	T7855	T7854	compound	Figure,2A
R1745	T7856	T7854	punct	),2A
R1746	T7857	T7832	punct	.,disappeared
R1747	T7859	T7860	prep	At,was
R1748	T7861	T7862	nummod	18,wk
R1749	T7862	T7859	pobj	wk,At
R1750	T7863	T7862	prep	of,wk
R1751	T7864	T7863	pobj	age,of
R1752	T7865	T7860	punct	", ",was
R1753	T7866	T7867	compound	body,weight
R1754	T7867	T7860	nsubj	weight,was
R1755	T7868	T7869	advmod	modestly,greater
R1756	T7869	T7860	acomp	greater,was
R1757	T7870	T7868	cc	but,modestly
R1758	T7871	T7868	conj	significantly,modestly
R1759	T7872	T7860	prep	in,was
R1760	T7873	T7874	amod	male,mice
R1761	T7874	T7872	pobj	mice,in
R1762	T7875	T7873	cc	and,male
R1763	T7876	T7873	conj	female,male
R1764	T7877	T7878	nmod	PGC,1α
R1765	T7878	T7874	nmod	1α,mice
R1766	T7879	T7878	punct	-,1α
R1767	T7880	T7878	punct	−,1α
R1768	T7881	T7878	punct	/,1α
R1769	T7882	T7878	punct	−,1α
R1770	T7883	T7860	prep	compared,was
R1771	T7884	T7883	prep	to,compared
R1772	T7885	T7886	npadvmod	sex,matched
R1773	T7886	T7888	amod	matched,controls
R1774	T7887	T7886	punct	-,matched
R1775	T7888	T7884	pobj	controls,to
R1776	T7889	T7890	nmod	PGC,1α
R1777	T7890	T7888	nmod	1α,controls
R1778	T7891	T7890	punct	-,1α
R1779	T7892	T7890	punct	+,1α
R1780	T7893	T7890	punct	/,1α
R1781	T7894	T7890	punct	+,1α
R1782	T7895	T7896	punct	(,2A
R1783	T7896	T7860	parataxis	2A,was
R1784	T7897	T7896	compound	Figure,2A
R1785	T7898	T7896	punct	),2A
R1786	T7899	T7860	punct	.,was
R1787	T7901	T7902	det	This,difference
R1788	T7902	T7904	nsubj	difference,was
R1789	T7903	T7902	compound	weight,difference
R1790	T7905	T7904	advmod	also,was
R1791	T7906	T7904	acomp	significant,was
R1792	T7907	T7904	prep	for,was
R1793	T7908	T7909	amod	female,mice
R1794	T7909	T7907	pobj	mice,for
R1795	T7910	T7911	nmod	PGC,1α
R1796	T7911	T7909	nmod	1α,mice
R1797	T7912	T7911	punct	-,1α
R1798	T7913	T7911	punct	−,1α
R1799	T7914	T7911	punct	/,1α
R1800	T7915	T7911	punct	−,1α
R1801	T7916	T7904	prep	at,was
R1802	T7917	T7918	nummod	24,wk
R1803	T7918	T7916	pobj	wk,at
R1804	T7919	T7918	prep	of,wk
R1805	T7920	T7919	pobj	age,of
R1806	T7921	T7922	punct	(,2A
R1807	T7922	T7904	parataxis	2A,was
R1808	T7923	T7922	compound	Figure,2A
R1809	T7924	T7922	punct	),2A
R1810	T7925	T7904	punct	.,was
R1811	T7927	T7928	det	The,gain
R1812	T7928	T7931	nsubjpass	gain,associated
R1813	T7929	T7928	amod	abnormal,gain
R1814	T7930	T7928	compound	weight,gain
R1815	T7932	T7928	prep	in,gain
R1816	T7933	T7934	nmod	PGC,1α
R1817	T7934	T7936	nmod	1α,mice
R1818	T7935	T7934	punct	-,1α
R1819	T7936	T7932	pobj	mice,in
R1820	T7937	T7934	punct	−,1α
R1821	T7938	T7934	punct	/,1α
R1822	T7939	T7934	punct	−,1α
R1823	T7940	T7931	auxpass	was,associated
R1824	T7941	T7931	neg	not,associated
R1825	T7942	T7931	prep	with,associated
R1826	T7943	T7942	pobj	differences,with
R1827	T7944	T7943	prep	in,differences
R1828	T7945	T7946	compound	food,intake
R1829	T7946	T7944	pobj	intake,in
R1830	T7947	T7948	punct	(,data
R1831	T7948	T7943	meta	data,differences
R1832	T7949	T7948	amod	unpublished,data
R1833	T7950	T7948	punct	),data
R1834	T7951	T7943	cc	or,differences
R1835	T7952	T7943	conj	alterations,differences
R1836	T7953	T7952	prep	in,alterations
R1837	T7954	T7955	amod	general,activity
R1838	T7955	T7953	pobj	activity,in
R1839	T7956	T7957	mark	as,monitored
R1840	T7957	T7931	advcl	monitored,associated
R1841	T7958	T7957	prep	for,monitored
R1842	T7959	T7960	nummod	48,h
R1843	T7960	T7958	pobj	h,for
R1844	T7961	T7962	punct	(,S1
R1845	T7962	T7957	parataxis	S1,monitored
R1846	T7963	T7962	compound	Figure,S1
R1847	T7964	T7962	punct	),S1
R1848	T7965	T7931	punct	.,associated
R1849	T7967	T7968	compound	Percent,fat
R1850	T7968	T7970	nsubj	fat,was
R1851	T7969	T7968	compound	body,fat
R1852	T7971	T7968	punct	", ",fat
R1853	T7972	T7973	mark	as,determined
R1854	T8077	T8074	conj	24,18
R1855	T7973	T7968	advcl	determined,fat
R1856	T7974	T7973	prep	by,determined
R1857	T8078	T8075	prep	of,wk
R1858	T7975	T7976	amod	dual,energy
R1859	T7976	T7978	compound	energy,absorption
R1860	T7977	T7976	punct	-,energy
R1861	T8079	T8078	pobj	age,of
R1862	T7978	T7974	pobj	absorption,by
R1863	T7979	T7978	compound	X-ray,absorption
R1864	T8080	T8060	punct	", ",accumulated
R1865	T7980	T7978	punct	(,absorption
R1866	T7981	T7978	appos	DEXA,absorption
R1867	T7982	T7970	punct	),was
R1868	T7983	T7970	punct	", ",was
R1869	T8081	T8082	amod	older,mice
R1870	T7984	T7970	acomp	greater,was
R1871	T7985	T7970	prep	in,was
R1872	T7986	T7987	nummod	18,wk
R1873	T7987	T7992	npadvmod	wk,old
R1874	T8082	T8060	nsubj	mice,accumulated
R1875	T7988	T7986	punct	-,18
R1876	T7989	T7986	cc	and,18
R1877	T7990	T7986	conj	24,18
R1878	T8083	T8082	amod	male,mice
R1879	T7991	T7987	punct	-,wk
R1880	T7992	T7994	amod	old,mice
R1881	T7993	T7992	punct	-,old
R1882	T8084	T8082	compound	mutant,mice
R1883	T7994	T7985	pobj	mice,in
R1884	T7995	T7994	amod	female,mice
R1885	T8085	T8082	punct	(,mice
R1886	T7996	T7997	nmod	PGC,1α
R1887	T7997	T7994	nmod	1α,mice
R1888	T7998	T7997	punct	-,1α
R1889	T8086	T8087	quantmod	over,7
R1890	T7999	T7997	punct	−,1α
R1891	T8000	T7997	punct	/,1α
R1892	T8087	T8088	nummod	7,mo
R1893	T8001	T7997	punct	−,1α
R1894	T8088	T8082	npadvmod	mo,mice
R1895	T8002	T7970	prep	compared,was
R1896	T8003	T8002	prep	to,compared
R1897	T8004	T8005	npadvmod	age,matched
R1898	T8089	T8088	prep	of,mo
R1899	T8005	T8007	amod	matched,counterparts
R1900	T8006	T8005	punct	-,matched
R1901	T8090	T8089	pobj	age,of
R1902	T8007	T8003	pobj	counterparts,to
R1903	T8008	T8007	amod	female,counterparts
R1904	T8091	T8060	punct	),accumulated
R1905	T8009	T8010	nmod	PGC,1α
R1906	T8010	T8007	nmod	1α,counterparts
R1907	T8011	T8010	punct	-,1α
R1908	T8092	T8093	amod	more,fat
R1909	T8012	T8010	punct	+,1α
R1910	T8013	T8010	punct	/,1α
R1911	T8014	T8010	punct	+,1α
R1912	T8093	T8060	dobj	fat,accumulated
R1913	T8015	T7970	punct	", ",was
R1914	T8016	T7970	advcl	indicating,was
R1915	T8094	T8093	compound	body,fat
R1916	T8017	T8018	mark	that,was
R1917	T8018	T8016	ccomp	was,indicating
R1918	T8095	T8093	prep	than,fat
R1919	T8019	T8020	det	the,difference
R1920	T8020	T8018	nsubj	difference,was
R1921	T8021	T8022	compound	body,weight
R1922	T8096	T8097	amod	male,controls
R1923	T8022	T8020	compound	weight,difference
R1924	T8023	T8018	prep	due,was
R1925	T8097	T8095	pobj	controls,than
R1926	T8024	T8023	punct	", ",due
R1927	T8098	T8097	compound	WT,controls
R1928	T8025	T8026	advmod	at,least
R1929	T8026	T8027	advmod	least,in
R1930	T8099	T8100	punct	(,2A
R1931	T8027	T8023	prep	in,due
R1932	T8028	T8027	amod	part,in
R1933	T8100	T8060	parataxis	2A,accumulated
R1934	T8029	T8023	punct	", ",due
R1935	T8030	T8023	pcomp	to,due
R1936	T8031	T8032	amod	increased,fat
R1937	T8032	T8023	pobj	fat,due
R1938	T8101	T8100	compound	Figure,2A
R1939	T8033	T8032	compound	body,fat
R1940	T8034	T8035	punct	(,2A
R1941	T8102	T8100	cc	and,2A
R1942	T8035	T8018	parataxis	2A,was
R1943	T8036	T8035	compound	Figure,2A
R1944	T8103	T8104	amod	unpublished,data
R1945	T8037	T8035	punct	),2A
R1946	T8104	T8100	conj	data,2A
R1947	T8038	T7970	punct	.,was
R1948	T8105	T8100	punct	),2A
R1949	T8040	T8041	amod	Lean,mass
R1950	T8041	T8042	nsubj	mass,was
R1951	T8106	T8060	punct	.,accumulated
R1952	T8043	T8042	neg	not,was
R1953	T8044	T8045	advmod	significantly,different
R1954	T8045	T8042	acomp	different,was
R1955	T8046	T8042	prep	between,was
R1956	T8108	T8109	amod	Individual,weights
R1957	T8047	T8048	det	the,genotypes
R1958	T8048	T8046	pobj	genotypes,between
R1959	T8049	T8050	punct	(,data
R1960	T8050	T8042	meta	data,was
R1961	T8109	T8111	nsubjpass	weights,assessed
R1962	T8051	T8050	amod	unpublished,data
R1963	T8110	T8109	compound	organ,weights
R1964	T8052	T8050	punct	),data
R1965	T8053	T8042	punct	.,was
R1966	T8112	T8111	auxpass	were,assessed
R1967	T8055	T8056	mark	Although,detect
R1968	T8056	T8060	advcl	detect,accumulated
R1969	T8057	T8056	nsubj	DEXA,detect
R1970	T8058	T8056	aux	did,detect
R1971	T8113	T8111	punct	", ",assessed
R1972	T8059	T8056	neg	not,detect
R1973	T8114	T8111	prep	given,assessed
R1974	T8061	T8062	amod	excess,fat
R1975	T8062	T8056	dobj	fat,detect
R1976	T8115	T8116	det	the,importance
R1977	T8063	T8062	compound	body,fat
R1978	T8064	T8056	prep	in,detect
R1979	T8065	T8066	amod	male,mice
R1980	T8116	T8114	pobj	importance,given
R1981	T8066	T8064	pobj	mice,in
R1982	T8067	T8068	nmod	PGC,1α
R1983	T8068	T8066	nmod	1α,mice
R1984	T8117	T8116	prep	of,importance
R1985	T8069	T8068	punct	-,1α
R1986	T8070	T8068	punct	−,1α
R1987	T8071	T8068	punct	/,1α
R1988	T8118	T8119	amod	mitochondrial,metabolism
R1989	T8072	T8068	punct	−,1α
R1990	T8073	T8056	prep	at,detect
R1991	T8074	T8075	nummod	18,wk
R1992	T8119	T8117	pobj	metabolism,of
R1993	T8075	T8073	pobj	wk,at
R1994	T8076	T8074	cc	or,18
R1995	T8120	T8119	compound	energy,metabolism
R1996	T8121	T8116	prep	for,importance
R1997	T8122	T8123	amod	postnatal,growth
R1998	T8123	T8121	pobj	growth,for
R1999	T8124	T8123	prep	in,growth
R2000	T8183	T8179	punct	+,1α
R2001	T8125	T8126	amod	certain,organs
R2002	T8184	T8131	prep	at,were
R2003	T8185	T8186	nummod	3,wk
R2004	T8186	T8184	pobj	wk,at
R2005	T8187	T8185	cc	and,3
R2006	T8126	T8124	pobj	organs,in
R2007	T8188	T8185	conj	8,3
R2008	T8189	T8186	prep	of,wk
R2009	T8190	T8189	pobj	age,of
R2010	T8127	T8111	punct	.,assessed
R2011	T8129	T8130	det	The,weights
R2012	T8191	T8192	punct	(,2B
R2013	T8192	T8131	parataxis	2B,were
R2014	T8193	T8192	compound	Figure,2B
R2015	T8194	T8192	cc	and,2B
R2016	T8195	T8196	amod	unpublished,data
R2017	T8130	T8131	nsubj	weights,were
R2018	T8196	T8192	conj	data,2B
R2019	T8197	T8192	punct	),2B
R2020	T8198	T8131	punct	.,were
R2021	T8132	T8130	prep	of,weights
R2022	T8200	T8201	prep	In,were
R2023	T8133	T8132	pobj	heart,of
R2024	T8202	T8200	pobj	contrast,In
R2025	T8203	T8201	punct	", ",were
R2026	T8134	T8133	cc	and,heart
R2027	T8204	T8205	det	the,weights
R2028	T8205	T8201	nsubj	weights,were
R2029	T8135	T8136	amod	slow,twitch
R2030	T8206	T8205	prep	of,weights
R2031	T8207	T8206	pobj	brain,of
R2032	T8208	T8207	punct	", ",brain
R2033	T8136	T8138	nmod	twitch,muscles
R2034	T8209	T8207	conj	liver,brain
R2035	T8210	T8209	punct	", ",liver
R2036	T8211	T8209	conj	kidney,liver
R2037	T8137	T8136	punct	-,twitch
R2038	T8212	T8211	punct	", ",kidney
R2039	T8213	T8211	cc	and,kidney
R2040	T8214	T8211	conj	BAT,kidney
R2041	T8138	T8133	conj	muscles,heart
R2042	T8215	T8201	neg	not,were
R2043	T8216	T8217	advmod	significantly,different
R2044	T8139	T8140	npadvmod	fiber,enriched
R2045	T8217	T8201	acomp	different,were
R2046	T8218	T8217	prep	between,different
R2047	T8219	T8220	det	the,genotypes
R2048	T8140	T8138	amod	enriched,muscles
R2049	T8220	T8218	pobj	genotypes,between
R2050	T8221	T8201	prep	at,were
R2051	T8222	T8223	det	the,point
R2052	T8141	T8140	punct	-,enriched
R2053	T8223	T8221	pobj	point,at
R2054	T8224	T8225	nummod	3,wk
R2055	T8225	T8223	compound	wk,point
R2056	T8226	T8225	punct	-,wk
R2057	T8227	T8223	compound	time,point
R2058	T8142	T8138	amod	skeletal,muscles
R2059	T8228	T8229	punct	(,2B
R2060	T8229	T8201	parataxis	2B,were
R2061	T8230	T8229	compound	Figure,2B
R2062	T8231	T8229	punct	),2B
R2063	T8143	T8138	punct	", ",muscles
R2064	T8144	T8138	prep	including,muscles
R2065	T8232	T8201	punct	.,were
R2066	T8234	T8235	advmod	Thus,exhibit
R2067	T8145	T8144	pobj	gastrocnemius,including
R2070	T8146	T8145	cc	and,gastrocnemius
R2071	T8238	T8235	nsubj	tissues,exhibit
R2072	T8239	T8238	prep	with,tissues
R2073	T8147	T8145	conj	soleus,gastrocnemius
R2074	T8240	T8241	amod	high,requirements
R2076	T8148	T8145	punct	", ",gastrocnemius
R2077	T8242	T8241	amod	mitochondrial,requirements
R2078	T8243	T8241	compound	energy,requirements
R2079	T8244	T8238	punct	", ",tissues
R2080	T8245	T8246	amod	such,as
R2081	T8149	T8145	cc	but,gastrocnemius
R2082	T8246	T8238	prep	as,tissues
R2083	T8247	T8248	nmod	heart,muscle
R2084	T8150	T8149	neg	not,but
R2086	T8249	T8247	cc	and,heart
R2087	T8250	T8251	amod	slow,twitch
R2088	T8151	T8152	det	the,anterior
R2089	T8251	T8253	npadvmod	twitch,skeletal
R2090	T8252	T8251	punct	-,twitch
R2091	T8253	T8247	conj	skeletal,heart
R2092	T8152	T8145	conj	anterior,gastrocnemius
R2093	T8254	T8235	punct	", ",exhibit
R2094	T8255	T8256	amod	modest,defects
R2095	T8153	T8154	advmod	less,oxidative
R2096	T8256	T8235	dobj	defects,exhibit
R2097	T8257	T8256	compound	growth,defects
R2098	T8258	T8235	prep	in,exhibit
R2099	T8259	T8260	nmod	PGC,1α
R2100	T8154	T8152	amod	oxidative,anterior
R2101	T8260	T8262	nmod	1α,mice
R2102	T8155	T8152	compound	tibialis,anterior
R2103	T8261	T8260	punct	-,1α
R2104	T8262	T8258	pobj	mice,in
R2105	T8263	T8260	punct	−,1α
R2106	T8156	T8131	punct	", ",were
R2107	T8264	T8260	punct	/,1α
R2108	T8265	T8260	punct	−,1α
R2109	T8266	T8235	punct	.,exhibit
R2110	T8157	T8158	advmod	significantly,lower
R2111	T8158	T8131	acomp	lower,were
R2112	T8159	T8131	prep	in,were
R2113	T8160	T8161	amod	male,mice
R2114	T8161	T8159	pobj	mice,in
R2115	T8162	T8160	cc	and,male
R2116	T8163	T8160	conj	female,male
R2117	T8164	T8165	nmod	PGC,1α
R2118	T8165	T8161	nmod	1α,mice
R2119	T8166	T8165	punct	-,1α
R2120	T8167	T8165	punct	−,1α
R2121	T8168	T8165	punct	/,1α
R2122	T8169	T8165	punct	−,1α
R2123	T8170	T8131	prep	compared,were
R2124	T8171	T8170	prep	with,compared
R2125	T8172	T8173	npadvmod	age,matched
R2126	T8173	T8177	amod	matched,controls
R2127	T8174	T8172	cc	and,age
R2128	T8175	T8172	conj	sex,age
R2129	T8176	T8173	punct	-,matched
R2130	T8177	T8171	pobj	controls,with
R2131	T8178	T8179	nmod	PGC,1α
R2132	T8179	T8177	nmod	1α,controls
R2133	T8180	T8179	punct	-,1α
R2134	T8181	T8179	punct	+,1α
R2135	T8182	T8179	punct	/,1α
R2136	T9816	T9817	amod	Abnormal,Phenotype
R2137	T9818	T9817	nmod	Muscle,Phenotype
R2138	T9819	T9817	amod	Mitochondrial,Phenotype
R2139	T9820	T9817	prep	in,Phenotype
R2140	T9821	T9822	nmod	PGC,1α
R2141	T9822	T9824	nmod	1α,Mice
R2142	T9823	T9822	punct	-,1α
R2143	T9824	T9820	pobj	Mice,in
R2144	T9825	T9822	punct	−,1α
R2145	T9826	T9822	punct	/,1α
R2146	T9827	T9822	punct	−,1α
R2147	T9829	T9830	amod	General,analyses
R2148	T9830	T9832	nsubjpass	analyses,performed
R2149	T9831	T9830	amod	histologic,analyses
R2150	T9833	T9832	auxpass	were,performed
R2151	T9834	T9835	aux	to,begin
R2152	T9835	T9832	advcl	begin,performed
R2153	T9836	T9837	aux	to,evaluate
R2154	T9837	T9835	xcomp	evaluate,begin
R2155	T9838	T9839	det	the,defect
R2156	T9839	T9837	dobj	defect,evaluate
R2157	T9840	T9839	amod	mild,defect
R2158	T9841	T9839	compound	growth,defect
R2159	T9842	T9839	acl	found,defect
R2160	T9843	T9842	prep	in,found
R2161	T9844	T9845	amod	postnatal,heart
R2162	T9845	T9843	pobj	heart,in
R2163	T9846	T9845	cc	and,heart
R2164	T9847	T9848	amod	skeletal,muscle
R2165	T9848	T9845	conj	muscle,heart
R2166	T9849	T9845	prep	of,heart
R2167	T9850	T9851	det	the,mice
R2168	T9851	T9849	pobj	mice,of
R2169	T9852	T9853	nmod	PGC,1α
R2170	T9853	T9851	nmod	1α,mice
R2171	T9854	T9853	punct	-,1α
R2172	T9855	T9853	punct	−,1α
R2173	T9856	T9853	punct	/,1α
R2174	T9857	T9853	punct	−,1α
R2175	T9858	T9832	punct	.,performed
R2176	T9860	T9861	expl	There,were
R2177	T9862	T9863	det	no,abnormalities
R2178	T9863	T9861	attr	abnormalities,were
R2179	T9864	T9863	amod	obvious,abnormalities
R2180	T9865	T9863	prep	in,abnormalities
R2181	T9866	T9865	pobj	cellularity,in
R2182	T9867	T9866	punct	", ",cellularity
R2183	T9868	T9869	compound	cell,size
R2184	T9869	T9866	conj	size,cellularity
R2185	T9870	T9869	punct	", ",size
R2186	T9871	T9869	cc	or,size
R2187	T9872	T9873	amod	extracellular,matrix
R2188	T9873	T9869	conj	matrix,size
R2189	T9874	T9861	prep	in,were
R2190	T9875	T9876	det	the,tissues
R2191	T9876	T9874	pobj	tissues,in
R2192	T9877	T9876	prep	of,tissues
R2193	T9878	T9879	quantmod	1,2
R2194	T9879	T9881	nummod	2,mo
R2195	T9880	T9879	punct	–,2
R2196	T9881	T9883	npadvmod	mo,old
R2197	T9882	T9881	punct	-,mo
R2198	T9883	T9885	amod	old,mice
R2199	T9884	T9883	punct	-,old
R2200	T9885	T9877	pobj	mice,of
R2201	T9886	T9887	nmod	PGC,1α
R2202	T9887	T9885	nmod	1α,mice
R2203	T9888	T9887	punct	-,1α
R2204	T9889	T9887	punct	−,1α
R2205	T9890	T9887	punct	/,1α
R2206	T9891	T9887	punct	−,1α
R2207	T9892	T9893	punct	(,data
R2208	T9893	T9861	meta	data,were
R2209	T9894	T9893	amod	unpublished,data
R2210	T9895	T9893	punct	),data
R2211	T9896	T9861	punct	.,were
R2212	T9898	T9899	prep	Given,examined
R2213	T9900	T9901	det	the,role
R2214	T9901	T9898	pobj	role,Given
R2215	T9902	T9901	amod	important,role
R2216	T9903	T9901	prep	of,role
R2217	T9904	T9905	compound	PGC,1α
R2218	T9905	T9903	pobj	1α,of
R2219	T9906	T9905	punct	-,1α
R2220	T9907	T9901	prep	in,role
R2221	T9908	T9909	amod	mitochondrial,function
R2222	T9909	T9907	pobj	function,in
R2223	T9910	T9909	cc	and,function
R2224	T9911	T9909	conj	biogenesis,function
R2225	T9912	T9899	punct	", ",examined
R2226	T9913	T9899	nsubj	we,examined
R2227	T9914	T9915	amod	mitochondrial,ultrastructure
R2228	T9915	T9899	dobj	ultrastructure,examined
R2229	T9916	T9899	prep	in,examined
R2230	T9917	T9918	det	the,tissues
R2231	T9918	T9916	pobj	tissues,in
R2232	T9919	T9918	amod	relevant,tissues
R2233	T9920	T9899	punct	.,examined
R2234	T9922	T9923	npadvmod	Electron,microscopic
R2235	T9923	T9924	amod	microscopic,analysis
R2236	T9924	T9925	nsubj	analysis,revealed
R2237	T9926	T9927	amod	fewer,mitochondria
R2238	T9927	T9925	dobj	mitochondria,revealed
R2239	T9928	T9926	cc	and,fewer
R2240	T9929	T9926	conj	smaller,fewer
R2241	T9930	T9927	prep	in,mitochondria
R2242	T9931	T9932	compound	soleus,muscle
R2243	T9932	T9930	pobj	muscle,in
R2244	T9933	T9932	prep	of,muscle
R2245	T9934	T9935	nmod	PGC,1α
R2246	T9935	T9937	nmod	1α,mice
R2247	T9936	T9935	punct	-,1α
R2248	T9937	T9933	pobj	mice,of
R2249	T9938	T9935	punct	−,1α
R2250	T9939	T9935	punct	/,1α
R2251	T9940	T9935	punct	−,1α
R2252	T9941	T9925	prep	compared,revealed
R2253	T9942	T9941	prep	to,compared
R2254	T9943	T9944	npadvmod	sex,matched
R2255	T9944	T9949	amod	matched,controls
R2256	T9945	T9943	punct	-,sex
R2257	T9946	T9943	cc	and,sex
R2258	T9947	T9943	conj	age,sex
R2259	T9948	T9944	punct	-,matched
R2260	T9949	T9942	pobj	controls,to
R2261	T9950	T9951	nmod	PGC,1α
R2262	T9951	T9949	nmod	1α,controls
R2263	T9952	T9951	punct	-,1α
R2264	T9953	T9951	punct	+,1α
R2265	T9954	T9951	punct	/,1α
R2266	T9955	T9951	punct	+,1α
R2267	T9956	T9957	punct	(,3A
R2268	T9957	T9925	parataxis	3A,revealed
R2269	T9958	T9957	compound	Figure,3A
R2270	T9959	T9957	punct	),3A
R2271	T9960	T9925	punct	.,revealed
R2272	T9962	T9963	amod	Quantitative,morphometry
R2273	T9963	T9964	nsubj	morphometry,confirmed
R2274	T9965	T9963	prep	of,morphometry
R2275	T9966	T9967	det	the,micrographs
R2276	T9967	T9965	pobj	micrographs,of
R2277	T9968	T9967	compound	electron,micrographs
R2278	T9969	T9970	mark	that,was
R2279	T9970	T9964	ccomp	was,confirmed
R2280	T9971	T9972	det	the,density
R2281	T9972	T9970	nsubj	density,was
R2282	T9973	T9972	amod	cellular,density
R2283	T9974	T9972	compound	volume,density
R2284	T9975	T9972	prep	of,density
R2285	T9976	T9977	compound	soleus,mitochondria
R2286	T9977	T9975	pobj	mitochondria,of
R2287	T9978	T9979	advmod	significantly,lower
R2288	T9979	T9970	acomp	lower,was
R2289	T9980	T9970	prep	in,was
R2290	T9981	T9982	nmod	PGC,1α
R2291	T9982	T9984	nmod	1α,mice
R2292	T9983	T9982	punct	-,1α
R2293	T9984	T9980	pobj	mice,in
R2294	T9985	T9982	punct	−,1α
R2295	T9986	T9982	punct	/,1α
R2296	T9987	T9982	punct	−,1α
R2297	T9988	T9970	prep	compared,was
R2298	T9989	T9988	prep	to,compared
R2299	T9990	T9991	nmod	PGC,1α
R2300	T9991	T9993	nmod	1α,controls
R2301	T9992	T9991	punct	-,1α
R2302	T9993	T9989	pobj	controls,to
R2303	T9994	T9991	punct	+,1α
R2304	T9995	T9991	punct	/,1α
R2305	T9996	T9991	punct	+,1α
R2306	T9997	T9970	advcl	independent,was
R2307	T9998	T9997	prep	of,independent
R2308	T9999	T9998	pobj	changes,of
R2309	T10000	T9999	prep	in,changes
R2310	T10001	T10002	det	the,component
R2311	T10002	T10000	pobj	component,in
R2312	T10003	T10002	amod	myofibrillar,component
R2313	T10004	T10005	punct	(,3B
R2314	T10005	T9964	parataxis	3B,confirmed
R2315	T10006	T10005	compound	Figure,3B
R2316	T10007	T10005	punct	),3B
R2317	T10008	T9964	punct	.,confirmed
R2318	T10010	T10011	advcl	Consistent,found
R2319	T10012	T10010	prep	with,Consistent
R2320	T10013	T10014	det	a,defect
R2321	T10014	T10012	pobj	defect,with
R2322	T10015	T10014	prep	in,defect
R2323	T10016	T10017	amod	mitochondrial,biogenesis
R2324	T10017	T10015	pobj	biogenesis,in
R2325	T10018	T10011	punct	", ",found
R2326	T10019	T10011	nsubj	we,found
R2327	T10020	T10021	det	a,reduction
R2328	T10021	T10011	dobj	reduction,found
R2329	T10022	T10021	prep	in,reduction
R2330	T10023	T10024	det	the,expression
R2331	T10024	T10022	pobj	expression,in
R2332	T10025	T10024	prep	of,expression
R2333	T10026	T10027	amod	nuclear,genes
R2334	T10027	T10025	pobj	genes,of
R2335	T10028	T10027	acl	encoding,genes
R2336	T10029	T10028	dobj	proteins,encoding
R2337	T10030	T10029	acl	involved,proteins
R2338	T10031	T10030	prep	in,involved
R2339	T10032	T10033	amod	mitochondrial,transport
R2340	T10033	T10031	pobj	transport,in
R2341	T10034	T10033	compound	electron,transport
R2342	T10035	T10029	punct	(,proteins
R2343	T10036	T10037	compound	cytochrome,c
R2344	T10037	T10029	appos	c,proteins
R2345	T10038	T10037	cc	and,c
R2346	T10039	T10040	compound	cytochrome,oxidase
R2347	T10040	T10037	conj	oxidase,c
R2348	T10041	T10040	nummod	IV,oxidase
R2349	T10042	T10029	punct	),proteins
R2350	T10043	T10029	cc	and,proteins
R2351	T10044	T10045	amod	oxidative,phosphorylation
R2352	T10045	T10029	conj	phosphorylation,proteins
R2353	T10046	T10045	punct	(,phosphorylation
R2354	T10047	T10048	compound	beta,subunit
R2355	T10048	T10045	appos	subunit,phosphorylation
R2356	T10049	T10048	prep	of,subunit
R2357	T10050	T10051	compound	ATP,synthase
R2358	T10051	T10049	pobj	synthase,of
R2359	T10052	T10028	punct	),encoding
R2360	T10053	T10028	prep	in,encoding
R2361	T10054	T10055	compound	soleus,muscle
R2362	T10055	T10053	pobj	muscle,in
R2363	T10056	T10055	prep	of,muscle
R2364	T10057	T10058	nmod	PGC,1α
R2365	T10058	T10060	nmod	1α,mice
R2366	T10059	T10058	punct	-,1α
R2367	T10060	T10056	pobj	mice,of
R2368	T10061	T10058	punct	−,1α
R2369	T10062	T10058	punct	/,1α
R2370	T10063	T10058	punct	−,1α
R2371	T10064	T10011	prep	compared,found
R2372	T10065	T10064	prep	with,compared
R2373	T10066	T10067	nmod	PGC,1α
R2374	T10067	T10069	nmod	1α,controls
R2375	T10068	T10067	punct	-,1α
R2376	T10069	T10065	pobj	controls,with
R2377	T10070	T10067	punct	+,1α
R2378	T10071	T10067	punct	/,1α
R2379	T10072	T10067	punct	+,1α
R2380	T10073	T10011	punct	.,found
R2381	T10075	T10076	prep	In,diminished
R2382	T10077	T10075	pobj	addition,In
R2383	T10078	T10076	punct	", ",diminished
R2384	T10079	T10080	det	the,expression
R2385	T10080	T10076	nsubjpass	expression,diminished
R2386	T10081	T10080	prep	of,expression
R2387	T10082	T10081	pobj	Tfam,of
R2388	T10083	T10082	punct	", ",Tfam
R2389	T10084	T10085	det	a,target
R2390	T10085	T10082	appos	target,Tfam
R2391	T10086	T10085	amod	known,target
R2392	T10087	T10088	compound	PGC,1α
R2393	T10088	T10085	compound	1α,target
R2394	T10089	T10088	punct	-,1α
R2395	T10090	T10085	acl	involved,target
R2396	T10091	T10090	prep	in,involved
R2397	T10092	T10093	amod	mitochondrial,transcription
R2398	T10093	T10091	pobj	transcription,in
R2399	T10094	T10093	compound	DNA,transcription
R2400	T10095	T10093	compound	replication,transcription
R2401	T10096	T10093	punct	/,transcription
R2402	T10097	T10076	punct	", ",diminished
R2403	T10098	T10076	auxpass	was,diminished
R2404	T10099	T10076	prep	in,diminished
R2405	T10100	T10101	nmod	PGC,1α
R2406	T10101	T10103	nmod	1α,soleus
R2407	T10102	T10101	punct	-,1α
R2408	T10103	T10099	pobj	soleus,in
R2409	T10104	T10101	punct	−,1α
R2410	T10105	T10101	punct	/,1α
R2411	T10106	T10101	punct	−,1α
R2412	T10107	T10076	punct	", ",diminished
R2413	T10108	T10076	advcl	providing,diminished
R2414	T10109	T10110	nummod	one,mechanism
R2415	T10110	T10108	dobj	mechanism,providing
R2416	T10111	T10110	amod	potential,mechanism
R2417	T10112	T10110	prep	for,mechanism
R2418	T10113	T10114	amod	defective,biogenesis
R2419	T10114	T10112	pobj	biogenesis,for
R2420	T10115	T10114	amod	mitochondrial,biogenesis
R2421	T10116	T10117	punct	(,3C
R2422	T10117	T10076	parataxis	3C,diminished
R2423	T10118	T10117	compound	Figure,3C
R2424	T10119	T10117	punct	),3C
R2425	T10120	T10076	punct	.,diminished
R2426	T10122	T10123	prep	In,noted
R2427	T10124	T10122	pobj	contrast,In
R2428	T10125	T10124	prep	to,contrast
R2429	T10126	T10127	det	the,results
R2430	T10127	T10125	pobj	results,to
R2431	T10128	T10127	prep	with,results
R2432	T10129	T10128	pobj	soleus,with
R2433	T10130	T10123	punct	", ",noted
R2434	T10131	T10132	det	no,differences
R2435	T10132	T10123	nsubjpass	differences,noted
R2436	T10133	T10132	amod	significant,differences
R2437	T10134	T10132	prep	in,differences
R2438	T10135	T10136	amod	mitochondrial,ultrastructure
R2439	T10136	T10134	pobj	ultrastructure,in
R2440	T10137	T10136	cc	or,ultrastructure
R2441	T10138	T10139	compound	volume,density
R2442	T10139	T10136	conj	density,ultrastructure
R2443	T10140	T10123	auxpass	were,noted
R2444	T10141	T10123	prep	in,noted
R2445	T10142	T10141	pobj	heart,in
R2446	T10143	T10142	cc	or,heart
R2447	T10144	T10142	conj	BAT,heart
R2448	T10145	T10142	prep	of,heart
R2449	T10146	T10147	nmod	PGC,1α
R2450	T10147	T10149	nmod	1α,mice
R2451	T10148	T10147	punct	-,1α
R2452	T10149	T10145	pobj	mice,of
R2453	T10150	T10147	punct	−,1α
R2454	T10151	T10147	punct	/,1α
R2455	T10152	T10147	punct	−,1α
R2456	T10153	T10154	punct	(,data
R2457	T10154	T10123	meta	data,noted
R2458	T10155	T10154	amod	unpublished,data
R2459	T10156	T10154	punct	),data
R2460	T10157	T10123	punct	.,noted
R2461	T10159	T10160	aux	To,determine
R2462	T10160	T10161	advcl	determine,measured
R2463	T10162	T10163	mark	whether,altered
R2464	T10163	T10160	ccomp	altered,determine
R2465	T10164	T10165	amod	mitochondrial,function
R2466	T10165	T10163	nsubjpass	function,altered
R2467	T10166	T10163	auxpass	was,altered
R2468	T10167	T10163	prep	in,altered
R2469	T10168	T10169	det	the,muscle
R2470	T10169	T10167	pobj	muscle,in
R2471	T10170	T10169	amod	skeletal,muscle
R2472	T10171	T10169	prep	of,muscle
R2473	T10172	T10173	nmod	PGC,1α
R2474	T10173	T10175	nmod	1α,mice
R2475	T10174	T10173	punct	-,1α
R2476	T10175	T10171	pobj	mice,of
R2477	T10176	T10173	punct	−,1α
R2478	T10177	T10173	punct	/,1α
R2479	T10178	T10173	punct	−,1α
R2480	T10179	T10161	punct	", ",measured
R2481	T10180	T10181	amod	mitochondrial,rates
R2482	T10181	T10161	nsubjpass	rates,measured
R2483	T10182	T10181	compound	respiration,rates
R2484	T10183	T10161	auxpass	were,measured
R2485	T10184	T10161	advcl	using,measured
R2486	T10185	T10186	compound	tissue,strips
R2487	T10186	T10184	dobj	strips,using
R2488	T10187	T10186	acl	prepared,strips
R2489	T10188	T10187	prep	from,prepared
R2490	T10189	T10190	compound	soleus,muscle
R2491	T10190	T10188	pobj	muscle,from
R2492	T10262	T10261	pobj	respiration,of
R2493	T10191	T10161	punct	.,measured
R2494	T10263	T10260	prep	to,coupling
R2495	T10193	T10194	prep	In,detected
R2496	T10264	T10265	compound	ATP,production
R2497	T10265	T10263	pobj	production,to
R2498	T10266	T10258	auxpass	was,altered
R2499	T10195	T10193	pobj	soleus,In
R2500	T10267	T10258	neg	not,altered
R2501	T10196	T10195	prep	of,soleus
R2502	T10268	T10258	advmod	significantly,altered
R2503	T10269	T10258	prep	in,altered
R2504	T10270	T10271	nmod	PGC,1α
R2505	T10197	T10198	nmod	PGC,1α
R2506	T10271	T10273	nmod	1α,mice
R2507	T10272	T10271	punct	-,1α
R2508	T10198	T10200	nmod	1α,mice
R2509	T10273	T10269	pobj	mice,in
R2510	T10274	T10271	punct	−,1α
R2511	T10199	T10198	punct	-,1α
R2512	T10275	T10271	punct	/,1α
R2513	T10276	T10271	punct	−,1α
R2514	T10200	T10196	pobj	mice,of
R2515	T10277	T10242	punct	.,were
R2516	T10279	T10280	det	These,results
R2517	T10201	T10198	punct	−,1α
R2518	T10280	T10281	nsubj	results,are
R2519	T10202	T10198	punct	/,1α
R2520	T10282	T10281	acomp	consistent,are
R2521	T10283	T10282	prep	with,consistent
R2522	T10203	T10198	punct	−,1α
R2523	T10284	T10285	det	the,reduction
R2524	T10285	T10283	pobj	reduction,with
R2525	T10286	T10285	amod	modest,reduction
R2526	T10204	T10194	punct	", ",detected
R2527	T10287	T10286	cc	but,modest
R2528	T10288	T10286	conj	significant,modest
R2529	T10289	T10285	prep	in,reduction
R2530	T10205	T10206	det	a,defect
R2531	T10290	T10291	amod	mitochondrial,density
R2532	T10291	T10289	pobj	density,in
R2533	T10292	T10291	compound	volume,density
R2534	T10293	T10281	punct	.,are
R2535	T10206	T10194	nsubjpass	defect,detected
R2536	T10207	T10206	amod	significant,defect
R2537	T10208	T10206	prep	in,defect
R2538	T10209	T10210	nmod	state,respiration
R2539	T10210	T10208	pobj	respiration,in
R2540	T10211	T10209	nummod	3,state
R2541	T10212	T10213	punct	(,stimulated
R2542	T10213	T10209	parataxis	stimulated,state
R2543	T10214	T10213	npadvmod	ADP,stimulated
R2544	T10215	T10213	punct	-,stimulated
R2545	T10216	T10213	punct	),stimulated
R2546	T10217	T10210	punct	", ",respiration
R2547	T10218	T10210	cc	but,respiration
R2548	T10219	T10218	neg	not,but
R2549	T10220	T10210	conj	state,respiration
R2550	T10221	T10220	nummod	2,state
R2551	T10222	T10223	punct	(,basal
R2552	T10223	T10220	parataxis	basal,state
R2553	T10224	T10223	punct	),basal
R2554	T10225	T10194	punct	", ",detected
R2555	T10226	T10194	auxpass	was,detected
R2556	T10227	T10194	advcl	using,detected
R2557	T10228	T10227	dobj	succinate,using
R2558	T10229	T10227	prep	as,using
R2559	T10230	T10231	det	the,substrate
R2560	T10231	T10229	pobj	substrate,as
R2561	T10232	T10233	punct	(,3D
R2562	T10233	T10194	parataxis	3D,detected
R2563	T10234	T10233	compound	Figure,3D
R2564	T10235	T10233	punct	),3D
R2565	T10236	T10194	punct	.,detected
R2566	T10238	T10239	nmod	State,rates
R2567	T10239	T10242	nsubj	rates,were
R2568	T10240	T10238	nummod	4,State
R2569	T10241	T10239	compound	respiration,rates
R2570	T10243	T10239	punct	(,rates
R2571	T10244	T10239	prep	in,rates
R2572	T10245	T10246	det	the,presence
R2573	T10246	T10244	pobj	presence,in
R2574	T10247	T10246	prep	of,presence
R2575	T10248	T10247	pobj	oligomycin,of
R2576	T10249	T10242	punct	),were
R2577	T10250	T10242	advmod	also,were
R2578	T10251	T10242	acomp	similar,were
R2579	T10252	T10242	prep	between,were
R2580	T10253	T10254	det	the,genotypes
R2581	T10254	T10252	pobj	genotypes,between
R2582	T10255	T10242	punct	", ",were
R2583	T10256	T10242	advcl	indicating,were
R2584	T10257	T10258	mark	that,altered
R2585	T10258	T10256	ccomp	altered,indicating
R2586	T10259	T10260	det	the,coupling
R2587	T10260	T10258	nsubjpass	coupling,altered
R2588	T10261	T10260	prep	of,coupling
R2589	T12484	T12485	amod	Altered,Function
R2590	T12486	T12487	amod	Skeletal,Muscle
R2591	T12487	T12485	compound	Muscle,Function
R2592	T12488	T12485	prep	in,Function
R2593	T12489	T12490	nmod	PGC,1α
R2594	T12490	T12492	nmod	1α,Mice
R2595	T12491	T12490	punct	-,1α
R2596	T12492	T12488	pobj	Mice,in
R2597	T12493	T12490	punct	−,1α
R2598	T12494	T12490	punct	/,1α
R2599	T12495	T12490	punct	−,1α
R2600	T12497	T12498	det	The,abnormality
R2601	T12498	T12499	nsubj	abnormality,led
R2602	T12500	T12498	prep	in,abnormality
R2603	T12501	T12502	amod	mitochondrial,number
R2604	T12502	T12500	pobj	number,in
R2605	T12503	T12502	cc	and,number
R2606	T12504	T12505	amod	respiratory,function
R2607	T12505	T12502	conj	function,number
R2608	T12506	T12498	prep	in,abnormality
R2609	T12507	T12508	amod	skeletal,muscle
R2610	T12508	T12506	pobj	muscle,in
R2611	T12509	T12499	dobj	us,led
R2612	T12510	T12511	aux	to,evaluate
R2613	T12511	T12499	xcomp	evaluate,led
R2614	T12512	T12511	advmod	further,evaluate
R2615	T12513	T12514	det	the,phenotype
R2616	T12514	T12511	dobj	phenotype,evaluate
R2617	T12515	T12516	amod	skeletal,muscle
R2618	T12516	T12514	compound	muscle,phenotype
R2619	T12517	T12499	punct	.,led
R2620	T12519	T12520	prep	As,measured
R2621	T12521	T12522	det	an,step
R2622	T12522	T12519	pobj	step,As
R2623	T12523	T12522	amod	initial,step
R2624	T12524	T12520	punct	", ",measured
R2625	T12525	T12520	nsubj	we,measured
R2626	T12526	T12527	compound	locomotor,levels
R2627	T12527	T12520	dobj	levels,measured
R2628	T12528	T12527	compound	activity,levels
R2629	T12529	T12520	prep	over,measured
R2630	T12530	T12531	det	a,period
R2631	T12531	T12529	pobj	period,over
R2632	T12532	T12533	nummod	1,h
R2633	T12533	T12531	compound	h,period
R2634	T12534	T12533	punct	-,h
R2635	T12535	T12520	advcl	using,measured
R2636	T12536	T12537	det	a,system
R2637	T12537	T12535	dobj	system,using
R2638	T12538	T12539	amod	high,resolution
R2639	T12539	T12537	compound	resolution,system
R2640	T12540	T12539	punct	-,resolution
R2641	T12541	T12537	compound	photobeam,system
R2642	T12542	T12520	punct	.,measured
R2643	T12544	T12545	nmod	PGC,1α
R2644	T12545	T12547	nmod	1α,mice
R2645	T12546	T12545	punct	-,1α
R2646	T12547	T12552	nsubj	mice,exhibited
R2647	T12548	T12545	punct	−,1α
R2648	T12549	T12545	punct	/,1α
R2649	T12550	T12545	punct	−,1α
R2650	T12551	T12547	amod	male,mice
R2651	T12553	T12554	det	a,number
R2652	T12554	T12552	dobj	number,exhibited
R2653	T12555	T12556	advmod	significantly,lower
R2654	T12556	T12554	amod	lower,number
R2655	T12557	T12554	amod	mean,number
R2656	T12558	T12554	prep	of,number
R2657	T12559	T12558	pobj	ambulations,of
R2658	T12560	T12559	cc	and,ambulations
R2659	T12561	T12559	conj	rearings,ambulations
R2660	T12562	T12552	prep	during,exhibited
R2661	T12563	T12564	det	the,hour
R2662	T12564	T12562	pobj	hour,during
R2663	T12565	T12552	prep	compared,exhibited
R2664	T12566	T12565	prep	to,compared
R2665	T12567	T12568	det	the,controls
R2666	T12568	T12566	pobj	controls,to
R2667	T12569	T12570	nmod	PGC,1α
R2668	T12570	T12568	nmod	1α,controls
R2669	T12571	T12570	punct	-,1α
R2670	T12572	T12570	punct	+,1α
R2671	T12573	T12570	punct	/,1α
R2672	T12574	T12570	punct	+,1α
R2673	T12575	T12576	npadvmod	age,matched
R2674	T12576	T12568	amod	matched,controls
R2675	T12577	T12576	punct	-,matched
R2676	T12578	T12579	punct	(,Figure
R2677	T12579	T12552	parataxis	Figure,exhibited
R2678	T12580	T12579	nummod	4,Figure
R2679	T12581	T12579	punct	),Figure
R2680	T12582	T12552	punct	.,exhibited
R2681	T12584	T12585	advmod	However,showed
R2682	T12586	T12585	punct	", ",showed
R2683	T12587	T12588	det	an,analysis
R2684	T12588	T12585	nsubj	analysis,showed
R2685	T12589	T12588	prep	of,analysis
R2686	T12590	T12591	amod	exploratory,behavior
R2687	T12591	T12589	pobj	behavior,of
R2688	T12592	T12593	mark	that,were
R2689	T12593	T12585	ccomp	were,showed
R2690	T12594	T12595	det	the,mice
R2691	T12595	T12593	nsubj	mice,were
R2692	T12596	T12597	nmod	PGC,1α
R2693	T12597	T12595	nmod	1α,mice
R2694	T12598	T12597	punct	-,1α
R2695	T12599	T12597	punct	−,1α
R2696	T12600	T12597	punct	/,1α
R2697	T12601	T12597	punct	−,1α
R2698	T12602	T12593	acomp	reluctant,were
R2699	T12603	T12604	aux	to,go
R2700	T12604	T12602	xcomp	go,reluctant
R2701	T12605	T12604	prep	into,go
R2702	T12606	T12607	det	the,center
R2703	T12607	T12605	pobj	center,into
R2704	T12608	T12607	prep	of,center
R2705	T12609	T12610	det	the,field
R2706	T12610	T12608	pobj	field,of
R2707	T12611	T12610	punct	“,field
R2708	T12612	T12593	punct	”,were
R2709	T12613	T12593	prep	compared,were
R2710	T12614	T12613	prep	to,compared
R2711	T12615	T12614	pobj	controls,to
R2712	T12616	T12585	punct	.,showed
R2713	T12618	T12619	advmod	Specifically,field
R2714	T12620	T12619	punct	", ",field
R2715	T12621	T12622	nmod	PGC,1α
R2716	T12622	T12624	nmod	1α,mice
R2717	T12623	T12622	punct	-,1α
R2718	T12624	T12619	nsubj	mice,field
R2719	T12625	T12622	punct	−,1α
R2720	T12626	T12622	punct	/,1α
R2721	T12627	T12622	punct	−,1α
R2722	T12628	T12619	acl	made,field
R2723	T12629	T12630	advmod	significantly,fewer
R2724	T12630	T12631	amod	fewer,entries
R2725	T12631	T12628	dobj	entries,made
R2726	T12632	T12631	prep	into,entries
R2727	T12633	T12619	punct	", ",field
R2728	T12634	T12619	acl	spent,field
R2729	T12635	T12636	advmod	significantly,less
R2730	T12636	T12637	amod	less,time
R2731	T12637	T12634	dobj	time,spent
R2732	T12638	T12634	prep	in,spent
R2733	T12639	T12619	punct	", ",field
R2734	T12640	T12619	cc	and,field
R2735	T12641	T12619	acl	traveled,field
R2736	T12642	T12643	det	a,distance
R2737	T12643	T12641	dobj	distance,traveled
R2738	T12644	T12645	advmod	significantly,shorter
R2739	T12645	T12643	amod	shorter,distance
R2740	T12646	T12643	prep	in,distance
R2741	T12647	T12648	det	the,area
R2742	T12648	T12646	pobj	area,in
R2743	T12649	T12648	amod	central,area
R2744	T12650	T12648	prep	of,area
R2745	T12651	T12619	det	the,field
R2746	T12652	T12619	punct	“,field
R2747	T12653	T12619	punct	",",field
R2748	T12654	T12619	punct	”,field
R2749	T12655	T12656	mark	although,was
R2750	T12656	T12619	advcl	was,field
R2751	T12657	T12656	nsubj	differences,was
R2752	T12658	T12657	prep	in,differences
R2753	T12659	T12658	pobj	distance,in
R2754	T12660	T12659	acl	traveled,distance
R2755	T12661	T12660	prep	in,traveled
R2756	T12662	T12663	det	the,zone
R2757	T12663	T12661	pobj	zone,in
R2758	T12664	T12663	amod	peripheral,zone
R2759	T12665	T12663	prep	of,zone
R2760	T12666	T12667	det	the,field
R2761	T12667	T12665	pobj	field,of
R2762	T12668	T12667	punct	“,field
R2763	T12669	T12656	punct	”,was
R2764	T12670	T12656	neg	not,was
R2765	T12671	T12672	advmod	significantly,different
R2766	T12672	T12656	acomp	different,was
R2767	T12673	T12656	prep	between,was
R2768	T12674	T12673	pobj	groups,between
R2769	T12675	T12676	punct	(,S2
R2770	T12676	T12656	parataxis	S2,was
R2771	T12677	T12676	compound	Figure,S2
R2772	T12678	T12676	punct	),S2
R2773	T12679	T12619	punct	.,field
R2774	T12681	T12682	det	These,data
R2775	T12682	T12683	nsubj	data,suggest
R2776	T12684	T12685	mark	that,affected
R2777	T12685	T12683	ccomp	affected,suggest
R2778	T12686	T12687	det	the,level
R2779	T12687	T12685	nsubjpass	level,affected
R2780	T12688	T12687	amod	general,level
R2781	T12689	T12687	compound	activity,level
R2782	T12690	T12685	aux	may,affected
R2783	T12691	T12685	aux	have,affected
R2784	T12692	T12685	auxpass	been,affected
R2785	T12693	T12685	agent	by,affected
R2786	T12694	T12695	det	the,reluctance
R2787	T12695	T12693	pobj	reluctance,by
R2788	T12765	T12764	punct	-,1α
R2789	T12696	T12695	prep	of,reluctance
R2790	T12697	T12698	det	the,mice
R2791	T12698	T12696	pobj	mice,of
R2792	T12766	T12762	pobj	mice,between
R2793	T12699	T12700	nmod	PGC,1α
R2794	T12767	T12764	punct	−,1α
R2795	T12768	T12764	punct	/,1α
R2796	T12769	T12764	punct	−,1α
R2797	T12770	T12766	cc	and,mice
R2798	T12771	T12772	nmod	PGC,1α
R2799	T12772	T12774	nmod	1α,controls
R2800	T12700	T12698	nmod	1α,mice
R2801	T12773	T12772	punct	-,1α
R2802	T12774	T12766	conj	controls,mice
R2803	T12701	T12700	punct	-,1α
R2804	T12775	T12772	punct	+,1α
R2805	T12776	T12772	punct	/,1α
R2806	T12777	T12772	punct	+,1α
R2807	T12702	T12700	punct	−,1α
R2808	T12778	T12760	prep	on,found
R2809	T12779	T12780	det	the,tests
R2810	T12703	T12700	punct	/,1α
R2811	T12780	T12778	pobj	tests,on
R2812	T12781	T12780	nmod	ledge,tests
R2813	T12782	T12781	punct	", ",ledge
R2814	T12704	T12700	punct	−,1α
R2815	T12783	T12781	conj	platform,ledge
R2816	T12784	T12783	punct	", ",platform
R2817	T12785	T12786	compound	walking,initiation
R2818	T12705	T12706	aux	to,go
R2819	T12786	T12783	conj	initiation,platform
R2820	T12787	T12786	punct	", ",initiation
R2821	T12788	T12786	cc	and,initiation
R2822	T12706	T12695	acl	go,reluctance
R2823	T12789	T12790	nummod	60,°
R2824	T12790	T12791	nmod	°,screen
R2825	T12791	T12786	conj	screen,initiation
R2826	T12707	T12706	prep	into,go
R2827	T12792	T12790	cc	and,°
R2828	T12793	T12794	nummod	90,°
R2829	T12794	T12790	conj	°,°
R2830	T12708	T12709	det	the,area
R2831	T12795	T12791	amod	inclined,screen
R2832	T12796	T12797	punct	(,data
R2833	T12709	T12707	pobj	area,into
R2834	T12797	T12760	meta	data,found
R2835	T12798	T12797	amod	unpublished,data
R2836	T12799	T12797	punct	),data
R2837	T12710	T12709	amod	central,area
R2838	T12800	T12760	punct	", ",found
R2839	T12801	T12760	advcl	suggesting,found
R2840	T12802	T12803	mark	that,were
R2841	T12711	T12709	prep	of,area
R2842	T12803	T12801	ccomp	were,suggesting
R2843	T12804	T12805	amod	several,functions
R2844	T12805	T12803	nsubj	functions,were
R2845	T12712	T12713	det	the,field
R2846	T12806	T12805	compound	sensorimotor,functions
R2847	T12807	T12803	acomp	intact,were
R2848	T12808	T12803	prep	in,were
R2849	T12809	T12810	det	the,mice
R2850	T12810	T12808	pobj	mice,in
R2851	T12811	T12812	nmod	PGC,1α
R2852	T12713	T12711	pobj	field,of
R2853	T12812	T12810	nmod	1α,mice
R2854	T12813	T12812	punct	-,1α
R2855	T12814	T12812	punct	−,1α
R2856	T12815	T12812	punct	/,1α
R2857	T12714	T12706	cc	and,go
R2858	T12816	T12812	punct	−,1α
R2859	T12817	T12760	punct	.,found
R2860	T12715	T12716	advmod	thus,remain
R2861	T12819	T12820	advmod	However,were
R2862	T12716	T12706	conj	remain,go
R2863	T12821	T12820	punct	", ",were
R2864	T12822	T12823	det	the,mice
R2865	T12823	T12820	nsubj	mice,were
R2866	T12717	T12716	prep	in,remain
R2867	T12824	T12825	nmod	PGC,1α
R2868	T12825	T12823	nmod	1α,mice
R2869	T12826	T12825	punct	-,1α
R2870	T12718	T12719	det	the,periphery
R2871	T12827	T12825	punct	−,1α
R2872	T12828	T12825	punct	/,1α
R2873	T12829	T12825	punct	−,1α
R2874	T12719	T12717	pobj	periphery,in
R2875	T12830	T12820	acomp	unable,were
R2876	T12831	T12832	aux	to,remain
R2877	T12720	T12695	punct	(,reluctance
R2878	T12832	T12830	xcomp	remain,unable
R2879	T12833	T12832	prep	on,remain
R2880	T12834	T12835	det	an,screen
R2881	T12721	T12695	appos	thigmotaxis,reluctance
R2882	T12835	T12833	pobj	screen,on
R2883	T12836	T12835	amod	inverted,screen
R2884	T12722	T12695	punct	),reluctance
R2885	T12837	T12832	prep	for,remain
R2886	T12838	T12839	advmod	as,long
R2887	T12839	T12837	pcomp	long,for
R2888	T12723	T12695	punct	", ",reluctance
R2891	T12724	T12725	advmod	possibly,reflecting
R2892	T12725	T12695	acl	reflecting,reluctance
R2893	T12842	T12840	pobj	controls,as
R2894	T12726	T12727	amod	altered,emotionality
R2895	T12843	T12844	nmod	PGC,1α
R2896	T12844	T12842	nmod	1α,controls
R2897	T12727	T12725	dobj	emotionality,reflecting
R2898	T12845	T12844	punct	-,1α
R2899	T12846	T12844	punct	+,1α
R2900	T12847	T12844	punct	/,1α
R2901	T12848	T12844	punct	+,1α
R2902	T12728	T12729	amod	such,as
R2903	T12849	T12850	punct	(,4A
R2904	T12850	T12820	parataxis	4A,were
R2905	T12851	T12850	compound	Figure,4A
R2906	T12729	T12727	prep	as,emotionality
R2907	T12852	T12850	punct	),4A
R2908	T12853	T12820	punct	.,were
R2909	T12730	T12731	amod	increased,fear
R2910	T12855	T12856	mark	Since,differ
R2911	T12731	T12729	pobj	fear,as
R2912	T12856	T12861	advcl	differ,suggest
R2913	T12857	T12858	det	the,groups
R2914	T12732	T12683	punct	.,suggest
R2915	T12858	T12856	nsubj	groups,differ
R2916	T12859	T12856	aux	did,differ
R2917	T12860	T12856	neg	not,differ
R2918	T12734	T12735	det	A,battery
R2919	T12862	T12856	prep	on,differ
R2920	T12863	T12864	det	the,times
R2921	T12864	T12862	pobj	times,on
R2922	T12735	T12736	nsubjpass	battery,performed
R2923	T12865	T12866	nsubj	it,took
R2924	T12866	T12864	advcl	took,times
R2925	T12867	T12868	aux	to,turn
R2926	T12737	T12735	prep	of,battery
R2927	T12868	T12866	xcomp	turn,took
R2928	T12869	T12868	advmod	around,turn
R2929	T12738	T12737	pobj	tests,of
R2930	T12739	T12736	auxpass	was,performed
R2931	T12740	T12741	aux	to,evaluate
R2932	T12870	T12868	cc	and,turn
R2933	T12741	T12736	advcl	evaluate,performed
R2934	T12871	T12868	conj	climb,turn
R2935	T12872	T12871	prep	to,climb
R2936	T12742	T12741	advmod	further,evaluate
R2937	T12873	T12874	det	the,top
R2938	T12874	T12872	pobj	top,to
R2939	T12875	T12874	prep	of,top
R2940	T12743	T12744	det	the,phenotype
R2941	T12876	T12877	nummod	60,°
R2942	T12877	T12878	nmod	°,screens
R2943	T12744	T12741	dobj	phenotype,evaluate
R2944	T12878	T12875	pobj	screens,of
R2945	T12879	T12877	cc	and,°
R2946	T12880	T12881	nummod	90,°
R2947	T12745	T12744	amod	general,phenotype
R2948	T12881	T12877	conj	°,°
R2949	T12882	T12878	amod	inclined,screens
R2950	T12883	T12861	punct	", ",suggest
R2951	T12746	T12744	compound	sensorimotor,phenotype
R2952	T12884	T12885	det	the,differences
R2953	T12885	T12861	nsubj	differences,suggest
R2954	T12886	T12885	prep	on,differences
R2955	T12887	T12888	det	the,test
R2956	T12888	T12886	pobj	test,on
R2957	T12889	T12888	amod	inverted,test
R2958	T12747	T12744	prep	of,phenotype
R2959	T12890	T12888	compound	screen,test
R2960	T12891	T12892	mark	that,were
R2961	T12748	T12749	det	the,mice
R2962	T12892	T12861	ccomp	were,suggest
R2963	T12893	T12894	amod	impaired,strength
R2964	T12894	T12892	nsubj	strength,were
R2965	T12749	T12747	pobj	mice,of
R2966	T12895	T12896	advmod	rather,than
R2967	T12896	T12894	cc	than,strength
R2968	T12897	T12894	conj	deficits,strength
R2969	T12750	T12751	nmod	PGC,1α
R2970	T12898	T12897	prep	in,deficits
R2971	T12899	T12898	pobj	coordination,in
R2972	T12900	T12892	acomp	responsible,were
R2973	T12751	T12749	nmod	1α,mice
R2974	T12901	T12900	prep	for,responsible
R2975	T12902	T12903	det	these,differences
R2976	T12903	T12901	pobj	differences,for
R2977	T12752	T12751	punct	-,1α
R2978	T12904	T12861	punct	.,suggest
R2979	T12906	T12907	aux	To,evaluate
R2980	T12753	T12751	punct	−,1α
R2981	T12907	T12909	advcl	evaluate,assessed
R2982	T12908	T12907	advmod	further,evaluate
R2983	T12754	T12751	punct	/,1α
R2984	T12910	T12911	det	the,phenotype
R2985	T12911	T12907	dobj	phenotype,evaluate
R2986	T12755	T12751	punct	−,1α
R2987	T12912	T12913	amod	skeletal,muscle
R2988	T12913	T12911	compound	muscle,phenotype
R2989	T12914	T12909	punct	", ",assessed
R2990	T12756	T12736	punct	.,performed
R2991	T12915	T12916	compound	exercise,capacity
R2992	T12916	T12909	nsubjpass	capacity,assessed
R2993	T12917	T12909	auxpass	was,assessed
R2994	T12758	T12759	det	No,differences
R2995	T12918	T12909	prep	in,assessed
R2996	T12919	T12920	det	the,mice
R2997	T12920	T12918	pobj	mice,in
R2998	T12759	T12760	nsubjpass	differences,found
R2999	T12921	T12922	nmod	PGC,1α
R3000	T12922	T12920	nmod	1α,mice
R3001	T12923	T12922	punct	-,1α
R3002	T12761	T12760	auxpass	were,found
R3003	T12924	T12922	punct	−,1α
R3004	T12925	T12922	punct	/,1α
R3005	T12926	T12922	punct	−,1α
R3006	T12927	T12909	punct	.,assessed
R3007	T12929	T12930	prep	To,exercised
R3008	T12762	T12760	prep	between,found
R3009	T12931	T12932	det	this,end
R3010	T12932	T12929	pobj	end,To
R3011	T12933	T12930	punct	", ",exercised
R3012	T12763	T12764	nmod	PGC,1α
R3013	T12934	T12935	det	the,mice
R3014	T12764	T12766	nmod	1α,mice
R3015	T12976	T12977	advmod	markedly,reduced
R3016	T12935	T12930	nsubjpass	mice,exercised
R3017	T12936	T12937	nmod	PGC,1α
R3018	T12937	T12935	nmod	1α,mice
R3019	T12938	T12937	punct	-,1α
R3020	T12939	T12937	punct	−,1α
R3021	T12940	T12937	punct	/,1α
R3022	T12977	T12975	amod	reduced,capacity
R3023	T12978	T12979	aux	to,sustain
R3024	T12979	T12975	acl	sustain,capacity
R3025	T12941	T12937	punct	−,1α
R3026	T12942	T12930	auxpass	were,exercised
R3027	T12980	T12981	compound	running,exercise
R3028	T12943	T12930	prep	on,exercised
R3029	T12944	T12945	det	a,apparatus
R3030	T12981	T12979	dobj	exercise,sustain
R3031	T12945	T12943	pobj	apparatus,on
R3032	T12946	T12945	amod	motorized,apparatus
R3033	T12947	T12945	compound	treadmill,apparatus
R3034	T12982	T12983	punct	(,4B
R3035	T12948	T12930	advcl	using,exercised
R3036	T12949	T12950	det	a,format
R3037	T12950	T12948	dobj	format,using
R3038	T12983	T12965	parataxis	4B,exhibited
R3039	T12951	T12950	nmod	run,format
R3040	T12952	T12951	punct	-,run
R3041	T12953	T12951	prep	to,run
R3042	T12984	T12985	nmod	PGC,1α
R3043	T12954	T12953	punct	-,to
R3044	T12955	T12953	pobj	exhaustion,to
R3045	T12956	T12930	punct	.,exercised
R3046	T12985	T12987	nmod	1α,mice
R3047	T12958	T12959	nmod	PGC,1α
R3048	T12986	T12985	punct	-,1α
R3049	T12959	T12961	nmod	1α,mice
R3050	T12960	T12959	punct	-,1α
R3051	T12987	T12991	dep	mice,s
R3052	T12961	T12965	nsubj	mice,exhibited
R3053	T12962	T12959	punct	−,1α
R3054	T12963	T12959	punct	/,1α
R3055	T12964	T12959	punct	−,1α
R3056	T12966	T12961	punct	(,mice
R3057	T12967	T12968	quantmod	6,8
R3058	T12988	T12985	punct	−,1α
R3059	T12968	T12970	nummod	8,mo
R3060	T12969	T12968	punct	–,8
R3061	T12970	T12961	npadvmod	mo,mice
R3062	T12989	T12985	punct	/,1α
R3063	T12971	T12970	prep	of,mo
R3064	T12972	T12971	pobj	age,of
R3065	T12973	T12961	punct	),mice
R3066	T12990	T12985	punct	−,1α
R3067	T12974	T12975	det	a,capacity
R3068	T12975	T12965	dobj	capacity,exhibited
R3069	T12991	T12983	dep	s,4B
R3070	T12992	T12991	punct	", ",s
R3071	T12993	T12994	quantmod	64,6
R3072	T12994	T12991	nummod	6,s
R3073	T13081	T13047	punct	.,measured
R3074	T12995	T12994	punct	±,6
R3075	T13083	T13084	nsubj	VO2max,was
R3076	T12996	T12983	punct	;,4B
R3077	T13085	T13086	advmod	significantly,lower
R3078	T13086	T13084	acomp	lower,was
R3079	T12997	T12998	npadvmod	age,matched
R3080	T13087	T13084	prep	for,was
R3081	T13088	T13089	det	the,mice
R3082	T13089	T13087	pobj	mice,for
R3083	T12998	T13000	amod	matched,mice
R3084	T13090	T13091	nmod	PGC,1α
R3085	T13091	T13089	nmod	1α,mice
R3086	T13092	T13091	punct	-,1α
R3087	T12999	T12998	punct	-,matched
R3088	T13093	T13091	punct	−,1α
R3089	T13000	T13007	dep	mice,s
R3090	T13001	T13002	nmod	PGC,1α
R3091	T13002	T13000	nmod	1α,mice
R3092	T13094	T13091	punct	/,1α
R3093	T13003	T13002	punct	-,1α
R3094	T13095	T13091	punct	−,1α
R3095	T13096	T13097	punct	(,O2
R3096	T13004	T13002	punct	+,1α
R3097	T13097	T13089	parataxis	O2,mice
R3098	T13098	T13099	quantmod	120.9,2.0
R3099	T13005	T13002	punct	/,1α
R3100	T13099	T13101	nummod	2.0,ml
R3101	T13100	T13099	punct	±,2.0
R3102	T13101	T13097	compound	ml,O2
R3103	T13102	T13097	punct	·,O2
R3104	T13006	T13002	punct	+,1α
R3105	T13103	T13097	appos	kg,O2
R3106	T13104	T13105	punct	−,1
R3107	T13007	T12983	dep	s,4B
R3108	T13105	T13103	nummod	1,kg
R3109	T13106	T13097	punct	·,O2
R3110	T13008	T13007	punct	", ",s
R3111	T13107	T13097	appos	min,O2
R3112	T13108	T13109	punct	−,1
R3113	T13009	T13010	quantmod	586,104
R3114	T13109	T13107	nummod	1,min
R3115	T13110	T13084	punct	),was
R3116	T13111	T13084	prep	compared,was
R3117	T13010	T13007	nummod	104,s
R3118	T13112	T13111	prep	to,compared
R3119	T13113	T13114	nmod	PGC,1α
R3120	T13011	T13010	punct	±,104
R3121	T13114	T13116	nmod	1α,controls
R3122	T13115	T13114	punct	-,1α
R3123	T13012	T12983	punct	;,4B
R3124	T13116	T13112	pobj	controls,to
R3125	T13117	T13114	punct	+,1α
R3126	T13118	T13114	punct	/,1α
R3127	T13013	T12983	compound	Figure,4B
R3128	T13119	T13114	punct	+,1α
R3129	T13120	T13121	punct	(,O2
R3130	T13121	T13116	parataxis	O2,controls
R3131	T13014	T12983	punct	),4B
R3132	T13122	T13123	quantmod	141.6,2.1
R3133	T13123	T13125	nummod	2.1,ml
R3134	T13124	T13123	punct	±,2.1
R3135	T13015	T12965	punct	.,exhibited
R3136	T13125	T13121	compound	ml,O2
R3137	T13126	T13121	punct	·,O2
R3138	T13127	T13121	appos	kg,O2
R3139	T13017	T13018	det	The,result
R3140	T13128	T13129	punct	−,1
R3141	T13129	T13127	nummod	1,kg
R3142	T13130	T13121	punct	·,O2
R3143	T13131	T13121	appos	min,O2
R3144	T13018	T13020	nsubjpass	result,obtained
R3145	T13132	T13133	punct	−,1
R3146	T13133	T13131	nummod	1,min
R3147	T13134	T13121	punct	),O2
R3148	T13019	T13018	amod	same,result
R3149	T13135	T13136	punct	(,4B
R3150	T13136	T13084	parataxis	4B,was
R3151	T13137	T13136	compound	Figure,4B
R3152	T13021	T13020	auxpass	was,obtained
R3153	T13138	T13136	punct	),4B
R3154	T13139	T13084	punct	.,was
R3155	T13141	T13142	aux	To,evaluate
R3156	T13022	T13020	prep	with,obtained
R3157	T13142	T13144	advcl	evaluate,determined
R3158	T13143	T13142	advmod	directly,evaluate
R3159	T13145	T13146	compound	muscle,fatigability
R3160	T13146	T13142	dobj	fatigability,evaluate
R3161	T13147	T13144	punct	", ",determined
R3162	T13023	T13024	amod	younger,mice
R3163	T13148	T13149	det	the,response
R3164	T13149	T13144	nsubjpass	response,determined
R3165	T13024	T13022	pobj	mice,with
R3166	T13150	T13149	compound	force,response
R3167	T13151	T13149	prep	to,response
R3168	T13152	T13153	amod	repetitive,stimulation
R3169	T13025	T13026	nmod	PGC,1α
R3170	T13153	T13151	pobj	stimulation,to
R3171	T13154	T13153	prep	of,stimulation
R3172	T13155	T13156	amod	isolated,muscle
R3173	T13026	T13024	nmod	1α,mice
R3174	T13156	T13154	pobj	muscle,of
R3175	T13157	T13156	compound	soleus,muscle
R3176	T13158	T13144	auxpass	was,determined
R3177	T13027	T13026	punct	-,1α
R3178	T13159	T13144	punct	.,determined
R3179	T13161	T13162	det	The,capacity
R3180	T13028	T13026	punct	−,1α
R3181	T13162	T13163	nsubj	capacity,is
R3182	T13164	T13165	aux	to,generate
R3183	T13029	T13026	punct	/,1α
R3184	T13165	T13162	acl	generate,capacity
R3185	T13166	T13165	dobj	force,generate
R3186	T13167	T13165	prep	following,generate
R3187	T13030	T13026	punct	−,1α
R3188	T13168	T13169	det	a,series
R3189	T13169	T13167	pobj	series,following
R3190	T13170	T13169	prep	of,series
R3191	T13031	T13024	punct	", ",mice
R3192	T13171	T13170	pobj	tetani,of
R3193	T13172	T13163	acomp	dependent,is
R3194	T13173	T13172	prep	upon,dependent
R3195	T13032	T13033	advmod	i.e.,at
R3196	T13174	T13175	amod	mitochondrial,production
R3197	T13175	T13173	pobj	production,upon
R3198	T13176	T13175	compound	ATP,production
R3199	T13033	T13024	prep	at,mice
R3200	T13177	T13163	punct	.,is
R3201	T13034	T13033	punct	", ",at
R3202	T13179	T13180	prep	During,was
R3203	T13181	T13182	det	the,phase
R3204	T13035	T13036	nummod	3.5,mo
R3205	T13182	T13179	pobj	phase,During
R3206	T13183	T13182	amod	initial,phase
R3207	T13184	T13182	prep	of,phase
R3208	T13036	T13033	pobj	mo,at
R3209	T13185	T13186	det	the,period
R3210	T13186	T13184	pobj	period,of
R3211	T13037	T13036	prep	of,mo
R3212	T13038	T13037	pobj	age,of
R3213	T13187	T13186	compound	stimulation,period
R3214	T13188	T13180	punct	", ",was
R3215	T13039	T13040	punct	(,data
R3216	T13189	T13180	expl	there,was
R3217	T13190	T13191	det	no,difference
R3218	T13191	T13180	attr	difference,was
R3219	T13040	T13020	meta	data,obtained
R3220	T13041	T13040	amod	unpublished,data
R3222	T13042	T13040	punct	),data
R3223	T13193	T13194	compound	force,generation
R3224	T13194	T13192	pobj	generation,in
R3225	T13195	T13180	prep	in,was
R3226	T13043	T13020	punct	.,obtained
R3227	T13196	T13195	pobj	muscles,in
R3228	T13197	T13196	acl	isolated,muscles
R3229	T13045	T13046	aux	To,quantify
R3230	T13198	T13197	prep	from,isolated
R3231	T13199	T13200	nmod	PGC,1α
R3232	T13200	T13202	nmod	1α,mice
R3233	T13046	T13047	advcl	quantify,measured
R3234	T13201	T13200	punct	-,1α
R3235	T13202	T13198	pobj	mice,from
R3236	T13203	T13200	punct	−,1α
R3237	T13048	T13049	amod	aerobic,capacity
R3238	T13204	T13200	punct	/,1α
R3239	T13205	T13200	punct	−,1α
R3240	T13206	T13202	cc	and,mice
R3241	T13049	T13046	dobj	capacity,quantify
R3242	T13207	T13208	nmod	PGC,1α
R3243	T13208	T13210	nmod	1α,controls
R3244	T13209	T13208	punct	-,1α
R3245	T13050	T13049	compound	exercise,capacity
R3246	T13210	T13202	conj	controls,mice
R3247	T13211	T13208	punct	+,1α
R3248	T13212	T13208	punct	/,1α
R3249	T13051	T13047	punct	", ",measured
R3250	T13213	T13208	punct	+,1α
R3251	T13214	T13180	punct	.,was
R3252	T13052	T13047	nsubjpass	VO2max,measured
R3253	T13216	T13217	advmod	However,was
R3254	T13053	T13052	punct	(,VO2max
R3255	T13218	T13217	punct	", ",was
R3256	T13219	T13220	compound	fatigue,resistance
R3257	T13220	T13221	compound	resistance,index
R3258	T13054	T13055	compound	maximum,consumption
R3259	T13221	T13217	nsubj	index,was
R3260	T13222	T13221	punct	", ",index
R3261	T13055	T13052	appos	consumption,VO2max
R3262	T13223	T13221	acl	defined,index
R3263	T13224	T13223	prep	as,defined
R3264	T13225	T13226	det	the,percent
R3265	T13226	T13224	pobj	percent,as
R3266	T13227	T13226	prep	of,percent
R3267	T13228	T13229	amod	initial,force
R3268	T13229	T13227	pobj	force,of
R3269	T13056	T13055	compound	oxygen,consumption
R3270	T13230	T13226	acl	generated,percent
R3271	T13231	T13230	prep	following,generated
R3272	T13232	T13233	det	a,series
R3273	T13057	T13055	punct	", ",consumption
R3274	T13233	T13231	pobj	series,following
R3275	T13234	T13235	nummod	2,min
R3276	T13058	T13055	acl	measured,consumption
R3277	T13235	T13233	compound	min,series
R3278	T13236	T13235	punct	-,min
R3279	T13237	T13233	prep	of,series
R3280	T13059	T13058	prep	in,measured
R3281	T13238	T13239	amod	fatiguing,contractions
R3282	T13239	T13237	pobj	contractions,of
R3283	T13240	T13217	punct	", ",was
R3284	T13060	T13059	pobj	milliliters,in
R3285	T13241	T13242	advmod	significantly,lower
R3286	T13242	T13217	acomp	lower,was
R3287	T13243	T13217	prep	in,was
R3288	T13061	T13060	prep	of,milliliters
R3289	T13244	T13245	det	the,mice
R3290	T13245	T13243	pobj	mice,in
R3291	T13246	T13247	nmod	PGC,1α
R3292	T13062	T13061	pobj	oxygen,of
R3293	T13247	T13245	nmod	1α,mice
R3294	T13248	T13247	punct	-,1α
R3295	T13249	T13247	punct	−,1α
R3296	T13063	T13060	prep	per,milliliters
R3297	T13250	T13247	punct	/,1α
R3298	T13251	T13247	punct	−,1α
R3299	T13252	T13253	punct	(,%
R3300	T13064	T13063	pobj	kilogram,per
R3301	T13253	T13245	parataxis	%,mice
R3302	T13254	T13255	quantmod	14.6,1.5
R3303	T13255	T13253	nummod	1.5,%
R3304	T13065	T13064	prep	of,kilogram
R3305	T13256	T13255	punct	±,1.5
R3306	T13257	T13217	punct	),was
R3307	T13258	T13217	prep	compared,was
R3308	T13066	T13067	compound	body,weight
R3309	T13259	T13258	prep	to,compared
R3310	T13260	T13261	nmod	PGC,1α
R3311	T13261	T13263	nmod	1α,controls
R3312	T13067	T13065	pobj	weight,of
R3313	T13262	T13261	punct	-,1α
R3314	T13263	T13259	pobj	controls,to
R3315	T13264	T13261	punct	+,1α
R3316	T13265	T13261	punct	/,1α
R3317	T13266	T13261	punct	+,1α
R3318	T13267	T13268	punct	(,%
R3319	T13068	T13060	prep	per,milliliters
R3320	T13268	T13263	parataxis	%,controls
R3321	T13269	T13270	quantmod	24.8,2.9
R3322	T13270	T13268	nummod	2.9,%
R3323	T13069	T13068	pobj	minute,per
R3324	T13271	T13270	punct	±,2.9
R3325	T13272	T13268	punct	),%
R3326	T13273	T13274	punct	(,4C
R3327	T13070	T13047	punct	),measured
R3328	T13071	T13047	auxpass	was,measured
R3329	T13072	T13047	prep	with,measured
R3330	T13274	T13217	parataxis	4C,was
R3331	T13275	T13274	compound	Figure,4C
R3332	T13276	T13274	punct	),4C
R3333	T13277	T13217	punct	.,was
R3334	T13073	T13074	det	the,protocol
R3335	T13074	T13072	pobj	protocol,with
R3336	T13279	T13280	det	These,results
R3337	T13075	T13074	nmod	treadmill,protocol
R3338	T13280	T13281	nsubj	results,indicate
R3339	T13076	T13075	punct	-,treadmill
R3340	T13282	T13280	punct	", ",results
R3341	T13077	T13075	amod	running,treadmill
R3342	T13283	T13280	advmod	together,results
R3343	T13284	T13283	prep	with,together
R3344	T13078	T13047	advcl	using,measured
R3345	T13285	T13286	det	the,abnormalities
R3346	T13286	T13284	pobj	abnormalities,with
R3347	T13079	T13080	amod	indirect,calorimetry
R3348	T13287	T13286	amod	observed,abnormalities
R3349	T13288	T13286	prep	in,abnormalities
R3350	T13080	T13078	dobj	calorimetry,using
R3351	T13289	T13290	amod	skeletal,structure
R3352	T13290	T13288	pobj	structure,in
R3353	T13291	T13290	nmod	muscle,structure
R3354	T13292	T13290	amod	mitochondrial,structure
R3355	T13293	T13290	cc	and,structure
R3356	T13294	T13290	conj	function,structure
R3357	T13295	T13281	punct	", ",indicate
R3358	T13296	T13297	mark	that,is
R3359	T13297	T13281	ccomp	is,indicate
R3360	T13298	T13299	compound	PGC,1α
R3361	T13299	T13297	nsubj	1α,is
R3362	T13300	T13299	punct	-,1α
R3363	T13301	T13297	acomp	necessary,is
R3364	T13302	T13301	prep	for,necessary
R3365	T13303	T13304	amod	functional,adaptation
R3366	T13304	T13302	pobj	adaptation,for
R3367	T13305	T13304	prep	of,adaptation
R3368	T13306	T13307	amod	skeletal,muscle
R3369	T13307	T13305	pobj	muscle,of
R3370	T13308	T13304	prep	to,adaptation
R3371	T13309	T13310	amod	physiologic,demands
R3372	T13310	T13308	pobj	demands,to
R3373	T13311	T13281	punct	.,indicate
R3375	T15167	T15168	amod	Functional,Abnormalities
R3376	T15169	T15168	prep	in,Abnormalities
R3377	T15170	T15169	pobj	Hearts,in
R3378	T15171	T15170	prep	of,Hearts
R3379	T15172	T15173	nmod	PGC,1α
R3380	T15173	T15175	nmod	1α,Mice
R3381	T15174	T15173	punct	-,1α
R3382	T15175	T15171	pobj	Mice,of
R3383	T15176	T15173	punct	−,1α
R3384	T15177	T15173	punct	/,1α
R3385	T15178	T15173	punct	−,1α
R3386	T15180	T15181	compound	PGC,1α
R3387	T15181	T15183	compound	1α,expression
R3388	T15182	T15181	punct	-,1α
R3389	T15183	T15184	nsubjpass	expression,enriched
R3390	T15185	T15184	auxpass	is,enriched
R3391	T15186	T15184	prep	in,enriched
R3392	T15187	T15186	pobj	heart,in
R3393	T15188	T15187	punct	", ",heart
R3394	T15189	T15190	det	a,tissue
R3395	T15190	T15187	appos	tissue,heart
R3396	T15191	T15192	dep	that,relies
R3397	T15192	T15190	relcl	relies,tissue
R3398	T15193	T15192	advmod	heavily,relies
R3399	T15194	T15192	prep	on,relies
R3400	T15195	T15196	amod	mitochondrial,metabolism
R3401	T15196	T15194	pobj	metabolism,on
R3402	T15197	T15196	compound	energy,metabolism
R3403	T15198	T15199	aux	to,maintain
R3404	T15199	T15192	advcl	maintain,relies
R3405	T15200	T15201	compound	pump,function
R3406	T15201	T15199	dobj	function,maintain
R3407	T15202	T15199	prep	throughout,maintain
R3408	T15203	T15204	det	the,life
R3409	T15204	T15202	pobj	life,throughout
R3410	T15205	T15204	amod	postnatal,life
R3411	T15206	T15204	prep	of,life
R3412	T15207	T15208	det	the,organism
R3413	T15208	T15206	pobj	organism,of
R3414	T15209	T15208	amod	mammalian,organism
R3415	T15210	T15184	punct	.,enriched
R3416	T15212	T15213	amod	Echocardiographic,studies
R3417	T15213	T15215	nsubj	studies,reveal
R3418	T15214	T15213	compound	screening,studies
R3419	T15216	T15213	prep	of,studies
R3420	T15217	T15218	nmod	PGC,1α
R3421	T15218	T15220	nmod	1α,mice
R3422	T15219	T15218	punct	-,1α
R3423	T15220	T15216	pobj	mice,of
R3424	T15221	T15218	punct	−,1α
R3425	T15222	T15218	punct	/,1α
R3426	T15223	T15218	punct	−,1α
R3427	T15224	T15213	prep	at,studies
R3428	T15225	T15226	nmod	ages,mo
R3429	T15226	T15224	pobj	mo,at
R3430	T15227	T15228	quantmod	4,6
R3431	T15228	T15226	nummod	6,mo
R3432	T15229	T15228	punct	–,6
R3433	T15230	T15215	aux	did,reveal
R3434	T15231	T15215	neg	not,reveal
R3435	T15232	T15233	det	any,differences
R3436	T15233	T15215	dobj	differences,reveal
R3437	T15234	T15233	amod	significant,differences
R3438	T15235	T15233	prep	in,differences
R3439	T15236	T15237	compound	chamber,sizes
R3440	T15237	T15235	pobj	sizes,in
R3441	T15238	T15237	cc	or,sizes
R3442	T15239	T15240	amod	ventricular,function
R3443	T15240	T15237	conj	function,sizes
R3444	T15241	T15215	prep	compared,reveal
R3445	T15242	T15241	prep	to,compared
R3446	T15243	T15244	compound	WT,controls
R3447	T15244	T15242	pobj	controls,to
R3448	T15245	T15246	punct	(,data
R3449	T15246	T15215	meta	data,reveal
R3450	T15247	T15246	amod	unpublished,data
R3451	T15248	T15246	punct	),data
R3452	T15249	T15215	punct	.,reveal
R3453	T15251	T15252	amod	Cardiac,functional
R3454	T15252	T15253	amod	functional,reserve
R3455	T15253	T15256	nsubjpass	reserve,evaluated
R3456	T15254	T15252	cc	and,functional
R3457	T15255	T15252	conj	metabolic,functional
R3458	T15257	T15256	auxpass	was,evaluated
R3459	T15258	T15256	advcl	using,evaluated
R3460	T15259	T15260	nmod	exercise,testing
R3461	T15260	T15258	dobj	testing,using
R3462	T15261	T15260	amod	echocardiographic,testing
R3463	T15262	T15260	compound	stress,testing
R3464	T15263	T15260	punct	(,testing
R3465	T15264	T15260	appos	EST,testing
R3466	T15265	T15256	punct	),evaluated
R3467	T15266	T15256	punct	.,evaluated
R3468	T15268	T15269	prep	Given,performed
R3469	T15270	T15271	mark	that,diminished
R3470	T15271	T15268	pcomp	diminished,Given
R3471	T15272	T15273	det	the,capacity
R3472	T15273	T15271	nsubjpass	capacity,diminished
R3473	T15274	T15273	compound	exercise,capacity
R3474	T15275	T15273	prep	of,capacity
R3475	T15276	T15277	nmod	PGC,1α
R3476	T15277	T15279	nmod	1α,mice
R3477	T15278	T15277	punct	-,1α
R3478	T15279	T15275	pobj	mice,of
R3479	T15280	T15277	punct	−,1α
R3480	T15281	T15277	punct	/,1α
R3481	T15282	T15277	punct	−,1α
R3482	T15283	T15271	auxpass	is,diminished
R3483	T15284	T15269	punct	", ",performed
R3484	T15285	T15286	det	a,series
R3485	T15286	T15269	nsubjpass	series,performed
R3486	T15287	T15286	prep	of,series
R3487	T15288	T15289	amod	preliminary,studies
R3488	T15289	T15287	pobj	studies,of
R3489	T15290	T15291	compound	treadmill,exercise
R3490	T15291	T15289	compound	exercise,studies
R3491	T15292	T15269	auxpass	were,performed
R3492	T15293	T15294	aux	to,define
R3493	T15294	T15269	advcl	define,performed
R3494	T15295	T15296	det	a,duration
R3495	T15296	T15294	dobj	duration,define
R3496	T15297	T15296	amod	reasonable,duration
R3497	T15298	T15296	compound	exercise,duration
R3498	T15299	T15296	prep	for,duration
R3499	T15300	T15301	csubjpass	run,used
R3500	T15301	T15299	pcomp	used,for
R3501	T15302	T15300	punct	-,run
R3502	T15303	T15300	prep	to,run
R3503	T15304	T15303	punct	-,to
R3504	T15305	T15303	pobj	exhaustion,to
R3505	T15306	T15301	aux	to,used
R3506	T15307	T15301	auxpass	be,used
R3507	T15308	T15301	prep	as,used
R3508	T15309	T15310	det	a,duration
R3509	T15310	T15308	pobj	duration,as
R3510	T15311	T15310	compound	target,duration
R3511	T15312	T15310	prep	for,duration
R3512	T15313	T15314	det	the,EST
R3513	T15314	T15312	pobj	EST,for
R3514	T15315	T15269	punct	.,performed
R3515	T15317	T15318	prep	Based,performed
R3516	T15319	T15317	prep	on,Based
R3517	T15320	T15321	det	the,results
R3518	T15321	T15319	pobj	results,on
R3519	T15322	T15321	prep	of,results
R3520	T15323	T15324	det	these,studies
R3521	T15324	T15322	pobj	studies,of
R3522	T15325	T15318	punct	", ",performed
R3523	T15326	T15327	det	an,regimen
R3524	T15327	T15318	nsubjpass	regimen,performed
R3525	T15328	T15327	compound	EST,regimen
R3526	T15329	T15318	auxpass	was,performed
R3527	T15330	T15331	prep	in,exercised
R3528	T15331	T15318	ccomp	exercised,performed
R3529	T15332	T15330	pobj	which,in
R3530	T15333	T15334	nmod	PGC,1α
R3531	T15334	T15336	nmod	1α,animals
R3532	T15335	T15334	punct	-,1α
R3533	T15336	T15331	nsubjpass	animals,exercised
R3534	T15337	T15334	punct	+,1α
R3535	T15338	T15334	punct	/,1α
R3536	T15339	T15334	punct	+,1α
R3537	T15340	T15336	compound	control,animals
R3538	T15341	T15331	auxpass	were,exercised
R3539	T15342	T15331	prep	for,exercised
R3540	T15343	T15344	det	a,duration
R3541	T15344	T15342	pobj	duration,for
R3542	T15345	T15344	prep	of,duration
R3543	T15346	T15347	nummod	60,s
R3544	T15347	T15345	pobj	s,of
R3545	T15348	T15349	aux	to,match
R3546	T15349	T15331	advcl	match,exercised
R3547	T15350	T15351	det	the,average
R3548	T15351	T15349	dobj	average,match
R3549	T15352	T15351	amod	predicted,average
R3550	T15353	T15351	prep	for,average
R3551	T15354	T15355	det	the,mice
R3552	T15355	T15353	pobj	mice,for
R3553	T15356	T15357	nmod	PGC,1α
R3554	T15357	T15355	nmod	1α,mice
R3555	T15358	T15357	punct	-,1α
R3556	T15359	T15357	punct	−,1α
R3557	T15360	T15357	punct	/,1α
R3558	T15361	T15357	punct	−,1α
R3559	T15362	T15363	punct	(,mo
R3560	T15363	T15355	parataxis	mo,mice
R3561	T15364	T15363	nmod	ages,mo
R3562	T15365	T15366	quantmod	6,8
R3563	T15366	T15363	nummod	8,mo
R3564	T15367	T15366	punct	–,8
R3565	T15368	T15363	punct	),mo
R3566	T15369	T15318	punct	.,performed
R3567	T15371	T15372	amod	Echocardiographic,images
R3568	T15372	T15373	nsubjpass	images,obtained
R3569	T15374	T15373	auxpass	were,obtained
R3570	T15375	T15376	advmod	immediately,following
R3571	T15376	T15373	prep	following,obtained
R3572	T15377	T15378	nummod	60,s
R3573	T15378	T15376	pobj	s,following
R3574	T15379	T15378	prep	of,s
R3575	T15380	T15379	pobj	exercise,of
R3576	T15381	T15378	prep	for,s
R3577	T15382	T15383	det	the,controls
R3578	T15383	T15381	pobj	controls,for
R3579	T15384	T15385	nmod	PGC,1α
R3580	T15385	T15383	nmod	1α,controls
R3581	T15386	T15385	punct	-,1α
R3582	T15387	T15385	punct	+,1α
R3583	T15388	T15385	punct	/,1α
R3584	T15389	T15385	punct	+,1α
R3585	T15390	T15376	cc	or,following
R3586	T15391	T15376	conj	at,following
R3587	T15392	T15393	det	the,point
R3588	T15393	T15391	pobj	point,at
R3589	T15394	T15393	prep	of,point
R3590	T15395	T15394	pobj	exhaustion,of
R3591	T15396	T15393	prep	for,point
R3592	T15397	T15398	nmod	PGC,1α
R3593	T15398	T15400	nmod	1α,mice
R3594	T15399	T15398	punct	-,1α
R3595	T15400	T15396	pobj	mice,for
R3596	T15401	T15398	punct	−,1α
R3597	T15402	T15398	punct	/,1α
R3598	T15403	T15398	punct	−,1α
R3599	T15404	T15405	punct	(,s
R3600	T15405	T15373	parataxis	s,obtained
R3601	T15406	T15407	dep	mean,s
R3602	T15407	T15405	dep	s,s
R3603	T15408	T15409	quantmod	60,6.1
R3604	T15409	T15407	nummod	6.1,s
R3605	T15410	T15409	punct	±,6.1
R3606	T15411	T15405	punct	", ",s
R3607	T15412	T15405	dep	range,s
R3608	T15413	T15414	quantmod	45,90
R3609	T15414	T15405	nummod	90,s
R3610	T15415	T15414	punct	–,90
R3611	T15416	T15405	punct	),s
R3612	T15417	T15373	punct	.,obtained
R3613	T15419	T15420	amod	Echocardiographic,determined
R3614	T15420	T15422	amod	determined,shortening
R3615	T15421	T15420	punct	-,determined
R3616	T15422	T15426	nsubjpass	shortening,monitored
R3617	T15423	T15424	amod	left,fractional
R3618	T15424	T15422	amod	fractional,shortening
R3619	T15425	T15424	amod	ventricular,fractional
R3620	T15427	T15422	cc	and,shortening
R3621	T15428	T15429	compound	heart,rate
R3622	T15429	T15422	conj	rate,shortening
R3623	T15430	T15426	auxpass	were,monitored
R3624	T15431	T15426	prep	for,monitored
R3625	T15432	T15433	det	the,period
R3626	T15433	T15431	pobj	period,for
R3627	T15434	T15435	nummod	10,min
R3628	T15435	T15433	compound	min,period
R3629	T15436	T15435	punct	-,min
R3630	T15437	T15438	advmod	immediately,post
R3631	T15438	T15433	prep	post,period
R3632	T15439	T15438	pobj	exercise,post
R3633	T15440	T15426	punct	.,monitored
R3634	T15442	T15443	det	The,rate
R3635	T15443	T15446	nsubj	rate,exhibited
R3636	T15444	T15443	amod	mean,rate
R3637	T15445	T15443	compound	heart,rate
R3638	T15447	T15443	prep	of,rate
R3639	T15448	T15449	det	the,mice
R3640	T15449	T15447	pobj	mice,of
R3641	T15450	T15451	nmod	PGC,1α
R3642	T15451	T15449	nmod	1α,mice
R3643	T15452	T15451	punct	-,1α
R3644	T15453	T15451	punct	−,1α
R3645	T15454	T15451	punct	/,1α
R3646	T15455	T15451	punct	−,1α
R3647	T15456	T15457	det	an,decline
R3648	T15457	T15446	dobj	decline,exhibited
R3649	T15458	T15457	amod	inappropriate,decline
R3650	T15459	T15446	prep	during,exhibited
R3651	T15460	T15461	det	the,period
R3652	T15461	T15459	pobj	period,during
R3653	T15462	T15463	amod	post,exercise
R3654	T15463	T15461	compound	exercise,period
R3655	T15464	T15465	punct	(,5A
R3656	T15465	T15446	parataxis	5A,exhibited
R3657	T15466	T15465	compound	Figure,5A
R3658	T15467	T15465	punct	),5A
R3659	T15468	T15446	punct	.,exhibited
R3660	T15470	T15471	prep	In,decreased
R3661	T15472	T15470	pobj	addition,In
R3662	T15473	T15471	punct	", ",decreased
R3663	T15474	T15475	advmod	echocardiographically,determined
R3664	T15475	T15476	amod	determined,shortening
R3665	T15476	T15471	nsubjpass	shortening,decreased
R3666	T15477	T15476	amod	left,shortening
R3667	T15478	T15476	amod	ventricular,shortening
R3668	T15479	T15476	amod	fractional,shortening
R3669	T15480	T15471	auxpass	was,decreased
R3670	T15481	T15471	prep	in,decreased
R3671	T15482	T15483	det	the,mice
R3672	T15483	T15481	pobj	mice,in
R3673	T15484	T15485	nmod	PGC,1α
R3674	T15485	T15483	nmod	1α,mice
R3675	T15486	T15485	punct	-,1α
R3676	T15487	T15485	punct	−,1α
R3677	T15488	T15485	punct	/,1α
R3678	T15489	T15485	punct	−,1α
R3679	T15490	T15483	punct	", ",mice
R3680	T15491	T15483	cc	but,mice
R3681	T15492	T15491	neg	not,but
R3682	T15493	T15494	det	the,mice
R3683	T15494	T15483	conj	mice,mice
R3684	T15495	T15496	nmod	PGC,1α
R3685	T15496	T15494	nmod	1α,mice
R3686	T15497	T15496	punct	-,1α
R3687	T15498	T15496	punct	+,1α
R3688	T15499	T15496	punct	/,1α
R3689	T15500	T15496	punct	+,1α
R3690	T15501	T15471	prep	during,decreased
R3691	T15502	T15503	det	the,min
R3692	T15503	T15501	pobj	min,during
R3693	T15504	T15503	amod	first,min
R3694	T15505	T15503	nummod	4,min
R3695	T15506	T15503	prep	of,min
R3696	T15507	T15508	det	the,period
R3697	T15508	T15506	pobj	period,of
R3698	T15509	T15510	amod	post,exercise
R3699	T15510	T15508	compound	exercise,period
R3700	T15511	T15512	punct	(,5A
R3701	T15512	T15471	parataxis	5A,decreased
R3702	T15513	T15512	compound	Figure,5A
R3703	T15514	T15512	punct	),5A
R3704	T15515	T15471	punct	.,decreased
R3705	T15517	T15518	det	The,results
R3706	T15518	T15519	nsubj	results,distinguish
R3707	T15520	T15518	prep	of,results
R3708	T15521	T15522	det	the,EST
R3709	T15522	T15520	pobj	EST,of
R3710	T15523	T15519	aux	did,distinguish
R3711	T15524	T15519	neg	not,distinguish
R3712	T15525	T15519	prep	between,distinguish
R3713	T15526	T15527	det	a,abnormality
R3714	T15527	T15525	pobj	abnormality,between
R3715	T15528	T15527	amod	primary,abnormality
R3716	T15529	T15527	amod	cardiac,abnormality
R3717	T15530	T15527	cc	versus,abnormality
R3718	T15531	T15527	conj	effects,abnormality
R3719	T15532	T15531	amod	secondary,effects
R3720	T15533	T15532	prep	to,secondary
R3721	T15534	T15535	det	the,exhaustion
R3722	T15535	T15533	pobj	exhaustion,to
R3723	T15536	T15535	acl	caused,exhaustion
R3724	T15537	T15536	agent	by,caused
R3725	T15538	T15539	amod	reduced,tolerance
R3726	T15539	T15537	pobj	tolerance,by
R3727	T15540	T15539	compound	exercise,tolerance
R3728	T15541	T15539	acl	related,tolerance
R3729	T15542	T15541	prep	to,related
R3730	T15543	T15544	amod	skeletal,muscle
R3731	T15544	T15545	compound	muscle,dysfunction
R3732	T15545	T15542	pobj	dysfunction,to
R3733	T15546	T15519	punct	.,distinguish
R3734	T15548	T15549	aux	To,assess
R3735	T15549	T15551	advcl	assess,isolated
R3736	T15550	T15549	advmod	directly,assess
R3737	T15552	T15553	amod	cardiac,function
R3738	T15553	T15549	dobj	function,assess
R3739	T15554	T15551	punct	", ",isolated
R3740	T15555	T15556	det	the,hearts
R3741	T15556	T15551	nsubjpass	hearts,isolated
R3742	T15557	T15556	prep	of,hearts
R3743	T15558	T15559	nmod	PGC,1α
R3744	T15559	T15561	nmod	1α,mice
R3745	T15560	T15559	punct	-,1α
R3746	T15561	T15557	pobj	mice,of
R3747	T15562	T15559	punct	−,1α
R3748	T15563	T15559	punct	/,1α
R3749	T15564	T15559	punct	−,1α
R3750	T15574	T15551	conj	perfused,isolated
R3751	T15565	T15559	cc	and,1α
R3752	T15575	T15574	prep	in,perfused
R3753	T15566	T15567	compound	PGC,1α
R3754	T15576	T15577	det	the,mode
R3755	T15577	T15575	pobj	mode,in
R3756	T15567	T15559	conj	1α,1α
R3757	T15578	T15577	compound	working,mode
R3758	T15579	T15551	punct	.,isolated
R3759	T15568	T15567	punct	-,1α
R3760	T15581	T15582	nsubj	Hearts,generated
R3761	T15583	T15581	acl	isolated,Hearts
R3762	T15584	T15583	prep	from,isolated
R3763	T15585	T15586	nmod	PGC,1α
R3764	T15586	T15588	nmod	1α,mice
R3765	T15587	T15586	punct	-,1α
R3766	T15569	T15567	punct	+,1α
R3767	T15588	T15584	pobj	mice,from
R3768	T15589	T15586	punct	−,1α
R3769	T15570	T15567	punct	/,1α
R3770	T15590	T15586	punct	/,1α
R3771	T15591	T15586	punct	−,1α
R3772	T15592	T15593	amod	lower,work
R3773	T15571	T15567	punct	+,1α
R3774	T15593	T15582	dobj	work,generated
R3775	T15594	T15593	amod	cardiac,work
R3776	T15572	T15551	auxpass	were,isolated
R3777	T15595	T15593	punct	(,work
R3778	T15596	T15597	amod	cardiac,output
R3779	T15597	T15593	appos	output,work
R3780	T15573	T15551	cc	and,isolated
R3781	T15598	T15597	acl	multiplied,output
R3782	T15599	T15598	prep	by,multiplied
R3783	T15600	T15601	nmod	peak,pressure
R3784	T15679	T15644	parataxis	Table,delineated
R3785	T15601	T15599	pobj	pressure,by
R3786	T15602	T15601	amod	systolic,pressure
R3787	T15603	T15593	punct	),work
R3788	T15604	T15593	prep	compared,work
R3789	T15605	T15604	prep	to,compared
R3790	T15680	T15679	nummod	1,Table
R3791	T15606	T15607	nmod	PGC,1α
R3792	T15607	T15609	nmod	1α,mice
R3793	T15608	T15607	punct	-,1α
R3794	T15609	T15605	pobj	mice,to
R3795	T15681	T15679	punct	),Table
R3796	T15610	T15607	punct	+,1α
R3797	T15611	T15607	punct	/,1α
R3798	T15682	T15644	punct	.,delineated
R3799	T15612	T15607	punct	+,1α
R3800	T15613	T15609	prep	at,mice
R3801	T15614	T15615	amod	identical,conditions
R3802	T15684	T15685	aux	To,distinguish
R3803	T15615	T15613	pobj	conditions,at
R3804	T15616	T15615	compound	loading,conditions
R3805	T15617	T15618	punct	(,Table
R3806	T15618	T15609	parataxis	Table,mice
R3807	T15619	T15618	nummod	1,Table
R3808	T15620	T15618	punct	),Table
R3809	T15685	T15687	advcl	distinguish,evaluated
R3810	T15621	T15582	punct	.,generated
R3811	T15623	T15624	det	This,reduction
R3812	T15686	T15685	advmod	further,distinguish
R3813	T15624	T15625	nsubj	reduction,was
R3814	T15688	T15685	prep	between,distinguish
R3815	T15626	T15624	prep	in,reduction
R3816	T15627	T15628	amod	cardiac,work
R3817	T15628	T15626	pobj	work,in
R3818	T15629	T15625	prep	due,was
R3819	T15689	T15688	pobj	abnormalities,between
R3820	T15630	T15629	pcomp	to,due
R3821	T15631	T15632	det	a,output
R3822	T15690	T15689	prep	in,abnormalities
R3823	T15691	T15692	compound	heart,rate
R3824	T15632	T15629	pobj	output,due
R3825	T15692	T15690	pobj	rate,in
R3826	T15633	T15632	amod	reduced,output
R3827	T15634	T15632	amod	cardiac,output
R3828	T15693	T15692	cc	and,rate
R3829	T15635	T15636	punct	(,Table
R3830	T15636	T15625	parataxis	Table,was
R3831	T15637	T15636	nummod	1,Table
R3832	T15694	T15695	amod	ventricular,function
R3833	T15638	T15636	punct	),Table
R3834	T15639	T15625	punct	.,was
R3835	T15695	T15692	conj	function,rate
R3836	T15641	T15642	det	The,contribution
R3837	T15696	T15687	punct	", ",evaluated
R3838	T15642	T15644	nsubjpass	contribution,delineated
R3839	T15643	T15642	amod	relative,contribution
R3840	T15645	T15642	prep	of,contribution
R3841	T15646	T15647	compound	heart,rate
R3842	T15697	T15698	advmod	in,vivo
R3843	T15698	T15699	amod	vivo,response
R3844	T15647	T15645	pobj	rate,of
R3845	T15648	T15647	cc	and,rate
R3846	T15699	T15687	nsubjpass	response,evaluated
R3847	T15649	T15650	compound	stroke,volume
R3848	T15650	T15647	conj	volume,rate
R3849	T15651	T15642	prep	to,contribution
R3850	T15700	T15699	amod	hemodynamic,response
R3851	T15652	T15653	amod	diminished,output
R3852	T15653	T15651	pobj	output,to
R3853	T15654	T15653	amod	cardiac,output
R3854	T15701	T15699	prep	to,response
R3855	T15655	T15653	prep	in,output
R3856	T15656	T15657	det	the,mice
R3857	T15702	T15703	det	the,agonist
R3858	T15657	T15655	pobj	mice,in
R3859	T15703	T15701	pobj	agonist,to
R3860	T15658	T15659	nmod	PGC,1α
R3861	T15659	T15657	nmod	1α,mice
R3862	T15704	T15705	nmod	β1,α1
R3863	T15660	T15659	punct	-,1α
R3864	T15661	T15659	punct	−,1α
R3865	T15705	T15707	npadvmod	α1,adrenergic
R3866	T15662	T15659	punct	/,1α
R3867	T15663	T15659	punct	−,1α
R3868	T15664	T15644	aux	could,delineated
R3869	T15706	T15705	punct	",",α1
R3870	T15665	T15644	neg	not,delineated
R3871	T15666	T15644	auxpass	be,delineated
R3872	T15707	T15709	amod	adrenergic,selective
R3873	T15667	T15644	punct	", ",delineated
R3874	T15668	T15669	mark	because,decreased
R3875	T15669	T15644	advcl	decreased,delineated
R3876	T15708	T15707	punct	-,adrenergic
R3877	T15670	T15669	nsubjpass	both,decreased
R3878	T15671	T15669	auxpass	were,decreased
R3879	T15709	T15703	amod	selective,agonist
R3880	T15672	T15669	cc	but,decreased
R3881	T15673	T15669	conj	neither,decreased
R3882	T15674	T15673	prep	to,neither
R3883	T15710	T15709	punct	-,selective
R3884	T15675	T15676	det	a,degree
R3885	T15676	T15674	pobj	degree,to
R3886	T15711	T15703	appos	dobutamine,agonist
R3887	T15677	T15676	amod	significant,degree
R3888	T15678	T15679	punct	(,Table
R3889	T15712	T15687	auxpass	was,evaluated
R3890	T15713	T15687	advcl	using,evaluated
R3891	T15714	T15715	det	a,catheter
R3892	T15715	T15713	dobj	catheter,using
R3893	T15716	T15715	amod	miniaturized,catheter
R3894	T15784	T15782	advmod	together,Taken
R3895	T15785	T15782	prep	with,Taken
R3896	T15717	T15715	compound	Millar,catheter
R3897	T15786	T15787	det	the,EST
R3898	T15787	T15785	pobj	EST,with
R3899	T15718	T15687	punct	.,evaluated
R3900	T15788	T15783	punct	", ",suggest
R3901	T15789	T15790	det	these,results
R3902	T15790	T15783	nsubj	results,suggest
R3903	T15720	T15721	det	The,response
R3904	T15791	T15783	advmod	strongly,suggest
R3905	T15792	T15793	mark	that,are
R3906	T15793	T15783	ccomp	are,suggest
R3907	T15721	T15724	nsubj	response,was
R3908	T15794	T15795	det	the,hearts
R3909	T15795	T15793	nsubj	hearts,are
R3910	T15796	T15797	nmod	PGC,1α
R3911	T15722	T15721	amod	ventricular,response
R3912	T15797	T15795	nmod	1α,hearts
R3913	T15798	T15797	punct	-,1α
R3914	T15799	T15797	punct	−,1α
R3915	T15723	T15721	amod	functional,response
R3916	T15800	T15797	punct	/,1α
R3917	T15801	T15797	punct	−,1α
R3918	T15802	T15793	acomp	unable,are
R3919	T15725	T15721	prep	to,response
R3920	T15803	T15804	aux	to,mount
R3921	T15804	T15802	xcomp	mount,unable
R3922	T15726	T15725	pobj	dobutamine,to
R3923	T15727	T15724	acomp	similar,was
R3924	T15805	T15806	det	an,response
R3925	T15806	T15804	dobj	response,mount
R3926	T15728	T15724	prep	in,was
R3927	T15807	T15806	amod	appropriate,response
R3928	T15808	T15806	amod	chronotropic,response
R3929	T15729	T15730	nmod	PGC,1α
R3930	T15809	T15806	prep	to,response
R3931	T15810	T15809	pobj	exercise,to
R3932	T15811	T15810	cc	and,exercise
R3933	T15812	T15813	amod	other,stimuli
R3934	T15730	T15732	nmod	1α,mice
R3935	T15813	T15810	conj	stimuli,exercise
R3936	T15814	T15813	amod	physiologic,stimuli
R3937	T15731	T15730	punct	-,1α
R3938	T15815	T15816	dep	that,activate
R3939	T15816	T15813	relcl	activate,stimuli
R3940	T15817	T15818	npadvmod	β,adrenergic
R3941	T15732	T15728	pobj	mice,in
R3942	T15818	T15820	amod	adrenergic,input
R3943	T15819	T15818	punct	-,adrenergic
R3944	T15820	T15816	dobj	input,activate
R3945	T15821	T15820	prep	to,input
R3946	T15822	T15823	det	the,heart
R3947	T15733	T15730	punct	+,1α
R3948	T15823	T15821	pobj	heart,to
R3949	T15824	T15783	punct	.,suggest
R3950	T15734	T15730	punct	/,1α
R3951	T15826	T15827	advmod	However,reveal
R3952	T15735	T15730	punct	+,1α
R3953	T15828	T15827	punct	", ",reveal
R3954	T15829	T15830	poss	our,results
R3955	T15830	T15827	nsubj	results,reveal
R3956	T15736	T15730	cc	and,1α
R3957	T15831	T15827	aux	did,reveal
R3958	T15832	T15827	neg	not,reveal
R3959	T15737	T15738	compound	PGC,1α
R3960	T15833	T15827	dobj	evidence,reveal
R3961	T15834	T15833	prep	for,evidence
R3962	T15738	T15730	conj	1α,1α
R3963	T15835	T15836	amod	contractile,dysfunction
R3964	T15836	T15834	pobj	dysfunction,for
R3965	T15837	T15827	punct	.,reveal
R3966	T15739	T15738	punct	-,1α
R3967	T15740	T15738	punct	−,1α
R3968	T15741	T15738	punct	/,1α
R3969	T15742	T15738	punct	−,1α
R3970	T15743	T15744	punct	(,graph
R3971	T15744	T15724	parataxis	graph,was
R3972	T15745	T15746	compound	Figure,5B
R3973	T15746	T15744	dep	5B,graph
R3974	T15747	T15744	punct	", ",graph
R3975	T15748	T15744	amod	right,graph
R3976	T15749	T15744	punct	),graph
R3977	T15750	T15724	punct	.,was
R3978	T15752	T15753	advmod	However,exhibited
R3979	T15754	T15753	punct	", ",exhibited
R3980	T15755	T15756	nmod	PGC,1α
R3981	T15756	T15758	nmod	1α,mice
R3982	T15757	T15756	punct	-,1α
R3983	T15758	T15753	nsubj	mice,exhibited
R3984	T15759	T15756	punct	−,1α
R3985	T15760	T15756	punct	/,1α
R3986	T15761	T15756	punct	−,1α
R3987	T15762	T15763	det	a,response
R3988	T15763	T15753	dobj	response,exhibited
R3989	T15764	T15765	advmod	significantly,blunted
R3990	T15765	T15763	amod	blunted,response
R3991	T15766	T15767	compound	heart,rate
R3992	T15767	T15763	compound	rate,response
R3993	T15768	T15763	prep	to,response
R3994	T15769	T15770	npadvmod	β,adrenergic
R3995	T15770	T15772	amod	adrenergic,stimulation
R3996	T15771	T15770	punct	-,adrenergic
R3997	T15772	T15768	pobj	stimulation,to
R3998	T15773	T15774	punct	(,graph
R3999	T15774	T15753	parataxis	graph,exhibited
R4000	T15775	T15776	compound	Figure,5B
R4001	T15776	T15774	dep	5B,graph
R4002	T15777	T15774	punct	", ",graph
R4003	T15778	T15774	amod	left,graph
R4004	T15779	T15774	punct	),graph
R4005	T15780	T15753	punct	.,exhibited
R4006	T15782	T15783	advcl	Taken,suggest
R4009	T17367	T17368	nmod	PGC,1α
R4010	T17368	T17370	nmod	1α,Mice
R4011	T17369	T17368	punct	-,1α
R4012	T17370	T17374	nsubj	Mice,Exhibit
R4013	T17371	T17368	punct	−,1α
R4014	T17372	T17368	punct	/,1α
R4015	T17373	T17368	punct	−,1α
R4016	T17375	T17376	det	an,Response
R4017	T17376	T17374	dobj	Response,Exhibit
R4018	T17377	T17376	amod	Abnormal,Response
R4019	T17378	T17376	amod	Thermogenic,Response
R4020	T17380	T17381	compound	PGC,1α
R4021	T17381	T17383	nsubjpass	1α,implicated
R4022	T17382	T17381	punct	-,1α
R4023	T17384	T17383	aux	has,implicated
R4024	T17385	T17383	auxpass	been,implicated
R4025	T17386	T17383	prep	as,implicated
R4026	T17387	T17388	det	an,regulator
R4027	T17388	T17386	pobj	regulator,as
R4028	T17389	T17388	amod	inducible,regulator
R4029	T17390	T17388	prep	of,regulator
R4030	T17391	T17392	amod	mitochondrial,uncoupling
R4031	T17392	T17390	pobj	uncoupling,of
R4032	T17393	T17392	amod	respiratory,uncoupling
R4033	T17394	T17392	punct	", ",uncoupling
R4034	T17395	T17396	det	an,source
R4035	T17396	T17392	appos	source,uncoupling
R4036	T17397	T17396	amod	important,source
R4037	T17398	T17396	prep	of,source
R4038	T17399	T17400	compound	heat,production
R4039	T17400	T17398	pobj	production,of
R4040	T17401	T17396	prep	in,source
R4041	T17402	T17401	pobj	BAT,in
R4042	T17403	T17404	punct	[,2
R4043	T17404	T17383	parataxis	2,implicated
R4044	T17405	T17404	punct	],2
R4045	T17406	T17383	punct	.,implicated
R4046	T17408	T17409	aux	To,determine
R4047	T17409	T17410	advcl	determine,subjected
R4048	T17411	T17412	mark	whether,is
R4049	T17412	T17409	ccomp	is,determine
R4050	T17413	T17414	compound	PGC,1α
R4051	T17414	T17412	nsubj	1α,is
R4052	T17415	T17414	punct	-,1α
R4053	T17416	T17412	acomp	necessary,is
R4054	T17417	T17416	prep	for,necessary
R4055	T17418	T17419	det	an,response
R4056	T17419	T17417	pobj	response,for
R4057	T17420	T17419	amod	appropriate,response
R4058	T17421	T17419	amod	thermogenic,response
R4059	T17422	T17410	punct	", ",subjected
R4060	T17423	T17424	nmod	PGC,1α
R4061	T17424	T17426	nmod	1α,mice
R4062	T17425	T17424	punct	-,1α
R4063	T17426	T17410	nsubjpass	mice,subjected
R4064	T17427	T17424	punct	+,1α
R4065	T17428	T17424	punct	/,1α
R4066	T17429	T17424	punct	+,1α
R4067	T17430	T17424	cc	and,1α
R4068	T17431	T17432	compound	PGC,1α
R4069	T17432	T17424	conj	1α,1α
R4070	T17433	T17432	punct	-,1α
R4071	T17434	T17432	punct	−,1α
R4072	T17435	T17432	punct	/,1α
R4073	T17436	T17432	punct	−,1α
R4074	T17437	T17410	auxpass	were,subjected
R4075	T17438	T17410	prep	to,subjected
R4076	T17439	T17440	compound	cold,exposure
R4077	T17440	T17438	pobj	exposure,to
R4078	T17441	T17442	punct	(,°C
R4079	T17442	T17440	parataxis	°C,exposure
R4080	T17443	T17442	nummod	4,°C
R4081	T17444	T17442	punct	),°C
R4082	T17445	T17410	prep	for,subjected
R4083	T17446	T17447	det	a,period
R4084	T17447	T17445	pobj	period,for
R4085	T17448	T17449	nummod	5,h
R4086	T17449	T17447	compound	h,period
R4087	T17450	T17449	punct	-,h
R4088	T17451	T17452	mark	while,monitored
R4089	T17452	T17410	advcl	monitored,subjected
R4090	T17453	T17454	compound	core,temperature
R4091	T17454	T17452	nsubjpass	temperature,monitored
R4092	T17455	T17454	compound	body,temperature
R4093	T17456	T17452	auxpass	was,monitored
R4094	T17457	T17410	punct	.,subjected
R4095	T17459	T17460	nmod	PGC,1α
R4096	T17460	T17462	nmod	1α,mice
R4097	T17461	T17460	punct	-,1α
R4098	T17462	T17466	nsubj	mice,exhibited
R4099	T17463	T17460	punct	−,1α
R4100	T17464	T17460	punct	/,1α
R4101	T17465	T17460	punct	−,1α
R4102	T17467	T17468	det	a,drop
R4103	T17468	T17466	dobj	drop,exhibited
R4104	T17469	T17470	advmod	markedly,abnormal
R4105	T17470	T17468	amod	abnormal,drop
R4106	T17471	T17468	prep	in,drop
R4107	T17472	T17473	compound	core,temperature
R4108	T17473	T17471	pobj	temperature,in
R4109	T17474	T17466	prep	compared,exhibited
R4110	T17475	T17474	prep	to,compared
R4111	T17476	T17477	det	the,controls
R4112	T17477	T17475	pobj	controls,to
R4113	T17478	T17477	compound	WT,controls
R4114	T17479	T17480	punct	(,6A
R4115	T17480	T17466	parataxis	6A,exhibited
R4116	T17481	T17480	compound	Figure,6A
R4117	T17482	T17480	punct	),6A
R4118	T17483	T17466	punct	.,exhibited
R4119	T17485	T17486	advmod	Specifically,was
R4120	T17487	T17486	punct	", ",was
R4121	T17488	T17489	det	the,decline
R4122	T17489	T17486	nsubj	decline,was
R4123	T17490	T17489	compound	mean,decline
R4124	T17491	T17489	prep	in,decline
R4125	T17492	T17493	compound	core,temperature
R4126	T17493	T17491	pobj	temperature,in
R4127	T17494	T17486	acomp	greater,was
R4128	T17495	T17494	prep	than,greater
R4129	T17496	T17497	nummod	12,°C
R4130	T17497	T17495	pobj	°C,than
R4131	T17498	T17486	prep	at,was
R4132	T17499	T17500	det	the,point
R4133	T17500	T17498	pobj	point,at
R4134	T17501	T17502	nummod	5,h
R4135	T17502	T17500	compound	h,point
R4136	T17503	T17502	punct	-,h
R4137	T17504	T17500	compound	time,point
R4138	T17505	T17486	prep	in,was
R4139	T17506	T17507	nmod	PGC,1α
R4140	T17507	T17509	nmod	1α,mice
R4141	T17508	T17507	punct	-,1α
R4142	T17509	T17505	pobj	mice,in
R4143	T17510	T17507	punct	−,1α
R4144	T17511	T17507	punct	/,1α
R4145	T17512	T17507	punct	−,1α
R4146	T17513	T17486	punct	", ",was
R4147	T17514	T17486	prep	compared,was
R4148	T17515	T17514	prep	to,compared
R4149	T17516	T17517	det	an,decrement
R4150	T17517	T17515	pobj	decrement,to
R4151	T17518	T17519	advmod	approximately,3
R4152	T17519	T17520	nummod	3,°C
R4153	T17520	T17517	compound	°C,decrement
R4154	T17521	T17517	prep	in,decrement
R4155	T17522	T17523	nmod	PGC,1α
R4156	T17523	T17525	nmod	1α,controls
R4157	T17524	T17523	punct	-,1α
R4158	T17525	T17521	pobj	controls,in
R4159	T17526	T17523	punct	+,1α
R4160	T17527	T17523	punct	/,1α
R4161	T17528	T17523	punct	+,1α
R4162	T17529	T17486	punct	.,was
R4163	T17531	T17532	mark	Although,was
R4164	T17532	T17536	advcl	was,was
R4165	T17533	T17534	det	this,phenotype
R4166	T17534	T17532	nsubj	phenotype,was
R4167	T17535	T17534	amod	thermogenic,phenotype
R4168	T17537	T17532	advmod	consistently,was
R4169	T17538	T17532	acomp	present,was
R4170	T17539	T17532	prep	in,was
R4171	T17540	T17539	pobj	mice,in
R4172	T17541	T17540	amod	aged,mice
R4173	T17542	T17543	quantmod	28,37
R4174	T17543	T17545	nummod	37,d
R4175	T17544	T17543	punct	–,37
R4176	T17545	T17541	npadvmod	d,aged
R4177	T17546	T17536	punct	", ",was
R4178	T17547	T17536	nsubj	it,was
R4179	T17548	T17536	acomp	absent,was
R4180	T17549	T17536	prep	in,was
R4181	T17550	T17551	amod	older,mice
R4182	T17551	T17549	pobj	mice,in
R4183	T17552	T17553	punct	(,data
R4184	T17553	T17536	meta	data,was
R4185	T17554	T17553	amod	unpublished,data
R4186	T17555	T17553	punct	),data
R4187	T17556	T17536	punct	.,was
R4188	T17558	T17559	det	The,appearance
R4189	T17559	T17561	nsubjpass	appearance,assessed
R4190	T17560	T17559	amod	histologic,appearance
R4191	T17562	T17559	cc	and,appearance
R4192	T17563	T17564	amod	neutral,stores
R4193	T17564	T17559	conj	stores,appearance
R4194	T17565	T17564	compound	lipid,stores
R4195	T17566	T17559	prep	of,appearance
R4196	T17567	T17566	pobj	BAT,of
R4197	T17568	T17561	auxpass	were,assessed
R4198	T17569	T17561	prep	as,assessed
R4199	T17570	T17571	det	an,step
R4200	T17571	T17569	pobj	step,as
R4201	T17572	T17571	amod	initial,step
R4202	T17573	T17574	aux	to,characterize
R4203	T17574	T17571	advcl	characterize,step
R4204	T17575	T17576	det	the,phenotype
R4205	T17576	T17574	dobj	phenotype,characterize
R4206	T17577	T17576	amod	thermogenic,phenotype
R4207	T17578	T17576	acl	exhibited,phenotype
R4208	T17579	T17578	agent	by,exhibited
R4209	T17580	T17581	nmod	PGC,1α
R4210	T17581	T17583	nmod	1α,mice
R4211	T17582	T17581	punct	-,1α
R4212	T17583	T17579	pobj	mice,by
R4213	T17584	T17581	punct	−,1α
R4214	T17585	T17581	punct	/,1α
R4215	T17586	T17581	punct	−,1α
R4216	T17587	T17561	punct	.,assessed
R4217	T17589	T17590	amod	Histologic,studies
R4218	T17590	T17594	nsubjpass	studies,performed
R4219	T17591	T17589	cc	and,Histologic
R4220	T17592	T17593	compound	lipid,quantification
R4221	T17593	T17589	conj	quantification,Histologic
R4222	T17595	T17594	auxpass	were,performed
R4223	T17596	T17594	punct	.,performed
R4224	T17598	T17599	npadvmod	Electron,microscopic
R4225	T17599	T17600	amod	microscopic,analyses
R4226	T17600	T17601	nsubj	analyses,indicated
R4227	T17602	T17603	mark	that,was
R4228	T17603	T17601	ccomp	was,indicated
R4229	T17604	T17605	det	the,ultrastructure
R4230	T17605	T17603	nsubj	ultrastructure,was
R4231	T17606	T17605	amod	mitochondrial,ultrastructure
R4232	T17607	T17603	acomp	similar,was
R4233	T17608	T17603	prep	in,was
R4234	T17609	T17608	pobj	BAT,in
R4235	T17610	T17609	acl	isolated,BAT
R4236	T17611	T17610	prep	from,isolated
R4237	T17612	T17613	nmod	PGC,1α
R4238	T17613	T17615	nmod	1α,mice
R4239	T17614	T17613	punct	-,1α
R4240	T17615	T17611	pobj	mice,from
R4241	T17616	T17613	punct	−,1α
R4242	T17617	T17613	punct	/,1α
R4243	T17618	T17613	punct	−,1α
R4244	T17619	T17613	cc	and,1α
R4245	T17620	T17621	compound	PGC,1α
R4246	T17621	T17613	conj	1α,1α
R4247	T17622	T17621	punct	-,1α
R4248	T17623	T17621	punct	+,1α
R4249	T17624	T17621	punct	/,1α
R4250	T17625	T17621	punct	+,1α
R4251	T17626	T17610	prep	before,isolated
R4252	T17627	T17626	cc	and,before
R4253	T17628	T17626	conj	after,before
R4254	T17629	T17630	compound	cold,exposure
R4255	T17630	T17628	pobj	exposure,after
R4256	T17631	T17632	punct	(,data
R4257	T17632	T17601	meta	data,indicated
R4258	T17633	T17632	amod	unpublished,data
R4259	T17634	T17632	punct	),data
R4260	T17635	T17601	punct	.,indicated
R4261	T17637	T17638	prep	In,were
R4262	T17639	T17637	pobj	addition,In
R4263	T17640	T17638	punct	", ",were
R4264	T17641	T17638	nsubj	levels,were
R4265	T17642	T17641	prep	of,levels
R4266	T17643	T17644	compound	BAT,triglyceride
R4267	T17644	T17642	pobj	triglyceride,of
R4268	T17645	T17638	acomp	similar,were
R4269	T17646	T17638	prep	between,were
R4270	T17647	T17648	det	the,genotypes
R4271	T17648	T17646	pobj	genotypes,between
R4272	T17649	T17648	nummod	two,genotypes
R4273	T17650	T17651	punct	(,data
R4274	T17651	T17638	meta	data,were
R4275	T17652	T17651	amod	unpublished,data
R4276	T17653	T17651	punct	),data
R4277	T17654	T17638	punct	.,were
R4278	T17656	T17657	nsubj	UCP,is
R4279	T17658	T17656	punct	-,UCP
R4280	T17659	T17656	nummod	1,UCP
R4281	T17660	T17661	det	a,protein
R4282	T17661	T17657	attr	protein,is
R4283	T17662	T17663	npadvmod	cold,inducible
R4284	T17663	T17661	amod	inducible,protein
R4285	T17664	T17663	punct	-,inducible
R4286	T17665	T17661	acl	involved,protein
R4287	T17666	T17665	prep	in,involved
R4288	T17667	T17668	amod	mitochondrial,uncoupling
R4289	T17668	T17666	pobj	uncoupling,in
R4290	T17669	T17668	amod	respiratory,uncoupling
R4291	T17670	T17671	aux	to,generate
R4292	T17671	T17665	advcl	generate,involved
R4293	T17672	T17671	dobj	heat,generate
R4294	T17673	T17671	prep	in,generate
R4295	T17674	T17673	pobj	BAT,in
R4296	T17675	T17657	punct	.,is
R4297	T17677	T17678	nmod	UCP,transcription
R4298	T17678	T17682	nsubjpass	transcription,known
R4299	T17679	T17677	punct	-,UCP
R4300	T17680	T17677	nummod	1,UCP
R4301	T17681	T17678	compound	gene,transcription
R4302	T17683	T17682	auxpass	is,known
R4303	T17684	T17685	aux	to,activated
R4304	T17685	T17682	xcomp	activated,known
R4305	T17686	T17685	auxpass	be,activated
R4306	T17687	T17685	agent	by,activated
R4307	T17688	T17689	compound	PGC,1α
R4308	T17689	T17687	pobj	1α,by
R4309	T17690	T17689	punct	-,1α
R4310	T17691	T17692	punct	[,2
R4311	T17692	T17682	parataxis	2,known
R4312	T17693	T17692	punct	],2
R4313	T17694	T17682	punct	.,known
R4314	T17696	T17697	advmod	Surprisingly,were
R4315	T17698	T17697	punct	", ",were
R4316	T17699	T17700	amod	basal,levels
R4317	T17700	T17697	nsubj	levels,were
R4318	T17701	T17699	cc	and,basal
R4319	T17702	T17703	npadvmod	cold,induced
R4320	T17703	T17699	conj	induced,basal
R4321	T17704	T17703	punct	-,induced
R4322	T17705	T17700	nmod	BAT,levels
R4323	T17706	T17700	nmod	UCP,levels
R4324	T17707	T17706	punct	-,UCP
R4325	T17708	T17706	nummod	1,UCP
R4326	T17709	T17700	compound	mRNA,levels
R4327	T17710	T17697	acomp	similar,were
R4328	T17711	T17697	prep	in,were
R4329	T17712	T17713	nmod	PGC,1α
R4330	T17713	T17715	nmod	1α,mice
R4331	T17714	T17713	punct	-,1α
R4332	T17715	T17711	pobj	mice,in
R4333	T17716	T17713	punct	+,1α
R4334	T17717	T17713	punct	/,1α
R4335	T17718	T17713	punct	+,1α
R4336	T17719	T17713	cc	and,1α
R4337	T17720	T17721	compound	PGC,1α
R4338	T17721	T17713	conj	1α,1α
R4339	T17722	T17721	punct	-,1α
R4340	T17723	T17721	punct	−,1α
R4341	T17724	T17721	punct	/,1α
R4342	T17725	T17721	punct	−,1α
R4343	T17726	T17727	punct	(,6B
R4344	T17727	T17697	parataxis	6B,were
R4345	T17728	T17727	compound	Figure,6B
R4346	T17729	T17727	punct	),6B
R4347	T17730	T17697	punct	.,were
R4348	T17732	T17733	det	These,results
R4349	T17733	T17734	nsubj	results,suggest
R4350	T17735	T17736	mark	that,is
R4351	T17736	T17734	advcl	is,suggest
R4352	T17737	T17738	compound	PGC,1α
R4353	T17738	T17736	nsubj	1α,is
R4354	T17739	T17738	punct	-,1α
R4355	T17740	T17736	neg	not,is
R4356	T17741	T17736	acomp	necessary,is
R4357	T17742	T17741	prep	for,necessary
R4358	T17743	T17744	det	the,induction
R4359	T17744	T17742	pobj	induction,for
R4360	T17745	T17744	prep	of,induction
R4361	T17746	T17747	det	the,expression
R4362	T17747	T17745	pobj	expression,of
R4363	T17748	T17747	prep	of,expression
R4364	T17749	T17748	pobj	UCP,of
R4365	T17750	T17749	punct	-,UCP
R4366	T17751	T17749	nummod	1,UCP
R4367	T17752	T17744	prep	with,induction
R4368	T17753	T17754	compound	cold,exposure
R4369	T17754	T17752	pobj	exposure,with
R4370	T17755	T17736	punct	", ",is
R4371	T17756	T17736	cc	and,is
R4372	T17757	T17758	mark	that,contribute
R4373	T17758	T17736	conj	contribute,is
R4374	T17759	T17760	amod	other,factors
R4375	T17760	T17758	nsubj	factors,contribute
R4376	T17761	T17760	punct	", ",factors
R4377	T17762	T17763	amod	such,as
R4378	T17763	T17760	prep	as,factors
R4379	T17764	T17765	amod	reduced,capacity
R4380	T17765	T17763	pobj	capacity,as
R4381	T17766	T17765	prep	for,capacity
R4382	T17767	T17768	amod	mitochondrial,respiration
R4383	T17768	T17766	pobj	respiration,for
R4384	T17769	T17758	punct	", ",contribute
R4385	T17770	T17758	advmod	likely,contribute
R4386	T17771	T17758	prep	to,contribute
R4387	T17772	T17773	det	the,response
R4388	T17773	T17771	pobj	response,to
R4389	T17774	T17773	amod	abnormal,response
R4390	T17775	T17773	amod	thermogenic,response
R4391	T17776	T17758	prep	in,contribute
R4392	T17777	T17778	det	the,mice
R4393	T17778	T17776	pobj	mice,in
R4394	T17779	T17780	nmod	PGC,1α
R4395	T17780	T17778	nmod	1α,mice
R4396	T17781	T17780	punct	-,1α
R4397	T17782	T17780	punct	−,1α
R4398	T17783	T17780	punct	/,1α
R4399	T17784	T17780	punct	−,1α
R4400	T17785	T17734	punct	.,suggest
R4401	T17787	T17788	nsubj	Thermogenesis,is
R4402	T17789	T17787	prep	in,Thermogenesis
R4403	T17790	T17789	pobj	rodents,in
R4404	T17791	T17787	acl	related,Thermogenesis
R4405	T17792	T17791	prep	to,related
R4406	T17793	T17794	amod	mitochondrial,uncoupling
R4407	T17794	T17792	pobj	uncoupling,to
R4408	T17795	T17788	prep	under,is
R4409	T17796	T17797	det	the,control
R4410	T17797	T17795	pobj	control,under
R4411	T17798	T17797	prep	of,control
R4412	T17799	T17800	npadvmod	β3,adrenergic
R4413	T17800	T17802	amod	adrenergic,receptor
R4414	T17801	T17800	punct	-,adrenergic
R4415	T17802	T17803	npadvmod	receptor,coupled
R4416	T17803	T17804	amod	coupled,signaling
R4417	T17804	T17798	pobj	signaling,of
R4418	T17805	T17788	punct	.,is
R4419	T17807	T17808	advmod	Accordingly,examined
R4420	T17809	T17808	punct	", ",examined
R4421	T17810	T17811	det	the,response
R4422	T17811	T17808	nsubjpass	response,examined
R4423	T17812	T17813	advmod	in,vivo
R4424	T17813	T17811	amod	vivo,response
R4425	T17814	T17815	compound	oxygen,consumption
R4426	T17815	T17811	compound	consumption,response
R4427	T17816	T17811	prep	to,response
R4428	T17817	T17818	npadvmod	β3,adrenergic
R4429	T17818	T17820	amod	adrenergic,stimulation
R4430	T17819	T17818	punct	-,adrenergic
R4431	T17820	T17816	pobj	stimulation,to
R4432	T17821	T17808	auxpass	was,examined
R4433	T17822	T17808	prep	in,examined
R4434	T17823	T17824	nmod	PGC,1α
R4435	T17824	T17826	nmod	1α,mice
R4436	T17825	T17824	punct	-,1α
R4437	T17826	T17822	pobj	mice,in
R4438	T17827	T17824	punct	−,1α
R4439	T17828	T17824	punct	/,1α
R4440	T17829	T17824	punct	−,1α
R4441	T17830	T17808	punct	.,examined
R4442	T17832	T17833	prep	For,measured
R4443	T17834	T17835	det	these,experiments
R4444	T17835	T17832	pobj	experiments,For
R4445	T17836	T17833	punct	", ",measured
R4446	T17837	T17833	nsubjpass	VO2,measured
R4447	T17838	T17837	punct	(,VO2
R4448	T17839	T17840	compound	oxygen,consumption
R4449	T17840	T17837	appos	consumption,VO2
R4450	T17841	T17837	punct	),VO2
R4451	T17842	T17833	auxpass	was,measured
R4452	T17843	T17833	prep	following,measured
R4453	T17844	T17843	pobj	administration,following
R4454	T17845	T17844	prep	of,administration
R4455	T17846	T17847	det	the,agonist
R4456	T17847	T17845	pobj	agonist,of
R4457	T17848	T17847	compound	β3,agonist
R4458	T17849	T17847	punct	-,agonist
R4459	T17850	T17847	appos	BRL,agonist
R4460	T17851	T17850	nummod	37344,BRL
R4461	T17852	T17833	advcl	using,measured
R4462	T17853	T17854	amod	indirect,calorimetry
R4463	T17854	T17852	dobj	calorimetry,using
R4464	T17855	T17833	punct	.,measured
R4465	T17857	T17858	nsubjpass	VO2,increased
R4466	T17859	T17858	auxpass	was,increased
R4467	T17860	T17858	advmod	significantly,increased
R4468	T17861	T17858	prep	in,increased
R4469	T17862	T17861	pobj	response,in
R4470	T17863	T17862	prep	to,response
R4471	T17864	T17863	pobj	BRL,to
R4472	T17865	T17864	nummod	3744,BRL
R4473	T17866	T17858	prep	in,increased
R4474	T17867	T17868	nmod	PGC,1α
R4475	T17868	T17870	nmod	1α,mice
R4476	T17869	T17868	punct	-,1α
R4477	T17870	T17866	pobj	mice,in
R4478	T17871	T17868	punct	+,1α
R4479	T17872	T17868	punct	/,1α
R4480	T17873	T17868	punct	+,1α
R4481	T17874	T17868	cc	but,1α
R4482	T17875	T17874	neg	not,but
R4483	T17876	T17877	compound	PGC,1α
R4484	T17877	T17868	conj	1α,1α
R4485	T17878	T17877	punct	-,1α
R4486	T17879	T17877	punct	−,1α
R4487	T17880	T17877	punct	/,1α
R4488	T17881	T17877	punct	−,1α
R4489	T17882	T17883	punct	(,6C
R4490	T17915	T17913	pobj	mice,in
R4491	T17883	T17858	parataxis	6C,increased
R4492	T17916	T17917	compound	PGC,1α
R4493	T17884	T17883	compound	Figure,6C
R4494	T17917	T17919	npadvmod	1α,null
R4495	T17918	T17917	punct	-,1α
R4496	T17919	T17915	amod	null,mice
R4497	T17885	T17883	punct	),6C
R4498	T17920	T17892	punct	", ",altered
R4499	T17921	T17922	advmod	likely,related
R4500	T17886	T17858	punct	.,increased
R4501	T17922	T17892	advcl	related,altered
R4502	T17923	T17922	prep	to,related
R4503	T17888	T17889	det	These,results
R4504	T17924	T17925	amod	reduced,capacity
R4505	T17925	T17923	pobj	capacity,to
R4506	T17926	T17925	prep	for,capacity
R4507	T17889	T17890	nsubj	results,indicate
R4508	T17927	T17928	amod	mitochondrial,uncoupling
R4509	T17928	T17926	pobj	uncoupling,for
R4510	T17929	T17928	amod	respiratory,uncoupling
R4511	T17891	T17892	mark	that,altered
R4512	T17930	T17890	punct	.,indicate
R4513	T17892	T17890	ccomp	altered,indicate
R4514	T17893	T17894	det	the,response
R4515	T17894	T17892	nsubjpass	response,altered
R4516	T17895	T17894	amod	metabolic,response
R4517	T17896	T17894	prep	of,response
R4518	T17897	T17896	pobj	BAT,of
R4519	T17898	T17894	prep	to,response
R4520	T17899	T17900	det	an,stimulus
R4521	T17900	T17898	pobj	stimulus,to
R4522	T17901	T17900	amod	acute,stimulus
R4523	T17902	T17903	amod	such,as
R4524	T17903	T17900	prep	as,stimulus
R4525	T17904	T17905	amod	cold,stimulation
R4526	T17905	T17903	pobj	stimulation,as
R4527	T17906	T17904	cc	and,cold
R4528	T17907	T17906	punct	/,and
R4529	T17908	T17906	cc	or,and
R4530	T17909	T17910	npadvmod	β3,adrenergic
R4531	T17910	T17904	conj	adrenergic,cold
R4532	T17911	T17910	punct	-,adrenergic
R4533	T17912	T17892	auxpass	is,altered
R4534	T17913	T17892	prep	in,altered
R4535	T17914	T17915	det	the,mice
R4536	T20245	T20246	npadvmod	Fasting,Induced
R4537	T20246	T20248	amod	Induced,Steatosis
R4538	T20247	T20246	punct	-,Induced
R4539	T20249	T20248	amod	Hepatic,Steatosis
R4540	T20250	T20248	prep	in,Steatosis
R4541	T20251	T20252	nmod	PGC,1α
R4542	T20252	T20254	nmod	1α,Mice
R4543	T20253	T20252	punct	-,1α
R4544	T20254	T20250	pobj	Mice,in
R4545	T20255	T20252	punct	−,1α
R4546	T20256	T20252	punct	/,1α
R4547	T20257	T20252	punct	−,1α
R4548	T20259	T20260	amod	Previous,studies
R4549	T20260	T20261	nsubj	studies,implicated
R4550	T20262	T20261	aux	have,implicated
R4551	T20263	T20264	compound	PGC,1α
R4552	T20264	T20261	dobj	1α,implicated
R4553	T20265	T20264	punct	-,1α
R4554	T20266	T20261	prep	in,implicated
R4555	T20267	T20268	amod	several,functions
R4556	T20268	T20266	pobj	functions,in
R4557	T20269	T20268	amod	hepatic,functions
R4558	T20270	T20268	amod	metabolic,functions
R4559	T20271	T20268	prep	including,functions
R4560	T20272	T20273	amod	fatty,acid
R4561	T20273	T20274	compound	acid,oxidation
R4562	T20274	T20271	pobj	oxidation,including
R4563	T20275	T20274	cc	and,oxidation
R4564	T20276	T20274	conj	gluconeogenesis,oxidation
R4565	T20277	T20278	punct	[,21
R4566	T20278	T20261	parataxis	21,implicated
R4567	T20279	T20278	nummod	18,21
R4568	T20280	T20278	punct	",",21
R4569	T20281	T20278	nummod	19,21
R4570	T20282	T20278	punct	",",21
R4571	T20283	T20278	nummod	20,21
R4572	T20284	T20278	punct	",",21
R4573	T20285	T20278	punct	],21
R4574	T20286	T20261	punct	.,implicated
R4575	T20288	T20289	advmod	Accordingly,evaluated
R4576	T20290	T20289	punct	", ",evaluated
R4577	T20291	T20292	det	the,phenotype
R4578	T20292	T20289	nsubjpass	phenotype,evaluated
R4579	T20293	T20292	amod	hepatic,phenotype
R4580	T20294	T20289	auxpass	was,evaluated
R4581	T20295	T20289	prep	under,evaluated
R4582	T20296	T20297	amod	basal,conditions
R4583	T20297	T20295	pobj	conditions,under
R4584	T20298	T20295	cc	and,under
R4585	T20299	T20295	conj	following,under
R4586	T20300	T20301	det	a,fast
R4587	T20301	T20299	pobj	fast,following
R4588	T20302	T20303	nummod	24,h
R4589	T20303	T20301	compound	h,fast
R4590	T20304	T20303	punct	-,h
R4591	T20305	T20301	punct	", ",fast
R4592	T20306	T20307	det	a,stimulus
R4593	T20307	T20301	appos	stimulus,fast
R4594	T20308	T20307	acl	known,stimulus
R4595	T20309	T20310	aux	to,induce
R4596	T20310	T20308	xcomp	induce,known
R4597	T20311	T20312	amod	fatty,acid
R4598	T20312	T20313	compound	acid,oxidation
R4599	T20313	T20310	dobj	oxidation,induce
R4600	T20314	T20313	cc	and,oxidation
R4601	T20315	T20316	amod	gluconeogenic,rates
R4602	T20316	T20313	conj	rates,oxidation
R4603	T20317	T20310	prep	in,induce
R4604	T20318	T20317	pobj	liver,in
R4605	T20319	T20289	punct	.,evaluated
R4606	T20321	T20322	prep	Under,appeared
R4607	T20323	T20324	amod	basal,conditions
R4608	T20324	T20321	pobj	conditions,Under
R4609	T20325	T20324	amod	fed,conditions
R4610	T20326	T20322	punct	", ",appeared
R4611	T20327	T20328	det	the,livers
R4612	T20328	T20322	nsubj	livers,appeared
R4613	T20329	T20328	prep	of,livers
R4614	T20330	T20331	det	the,mice
R4615	T20331	T20329	pobj	mice,of
R4616	T20332	T20333	nmod	PGC,1α
R4617	T20333	T20331	nmod	1α,mice
R4618	T20334	T20333	punct	-,1α
R4619	T20335	T20333	punct	−,1α
R4620	T20336	T20333	punct	/,1α
R4621	T20337	T20333	punct	−,1α
R4622	T20338	T20339	advmod	grossly,normal
R4623	T20339	T20322	oprd	normal,appeared
R4624	T20340	T20322	cc	and,appeared
R4625	T20341	T20342	aux	did,exhibit
R4626	T20342	T20322	conj	exhibit,appeared
R4627	T20343	T20342	neg	not,exhibit
R4628	T20344	T20345	amod	histologic,abnormalities
R4629	T20345	T20342	dobj	abnormalities,exhibit
R4630	T20346	T20347	punct	(,data
R4631	T20347	T20342	meta	data,exhibit
R4632	T20348	T20347	amod	unpublished,data
R4633	T20349	T20347	punct	),data
R4634	T20350	T20322	punct	.,appeared
R4635	T20352	T20353	advmod	However,exhibited
R4636	T20354	T20353	punct	", ",exhibited
R4637	T20355	T20353	prep	following,exhibited
R4638	T20356	T20357	det	a,fast
R4639	T20357	T20355	pobj	fast,following
R4640	T20358	T20359	nummod	24,h
R4641	T20359	T20357	compound	h,fast
R4642	T20360	T20357	punct	-,fast
R4643	T20361	T20353	punct	", ",exhibited
R4644	T20362	T20363	det	the,mice
R4645	T20363	T20353	nsubj	mice,exhibited
R4646	T20364	T20365	nmod	PGC,1α
R4647	T20365	T20363	nmod	1α,mice
R4648	T20366	T20365	punct	-,1α
R4649	T20367	T20365	punct	−,1α
R4650	T20368	T20365	punct	/,1α
R4651	T20369	T20365	punct	−,1α
R4652	T20370	T20371	amod	marked,steatosis
R4653	T20371	T20353	dobj	steatosis,exhibited
R4654	T20372	T20371	amod	hepatic,steatosis
R4655	T20373	T20374	mark	as,determined
R4656	T20374	T20353	advcl	determined,exhibited
R4657	T20375	T20374	agent	by,determined
R4658	T20376	T20377	amod	gross,inspection
R4659	T20377	T20375	pobj	inspection,by
R4660	T20378	T20377	punct	", ",inspection
R4661	T20379	T20380	nmod	oil,O
R4662	T20380	T20382	compound	O,staining
R4663	T20381	T20380	amod	red,O
R4664	T20382	T20377	conj	staining,inspection
R4665	T20383	T20382	punct	", ",staining
R4666	T20384	T20385	compound	electron,microscopy
R4667	T20385	T20382	conj	microscopy,staining
R4668	T20386	T20385	punct	", ",microscopy
R4669	T20387	T20385	cc	and,microscopy
R4670	T20388	T20385	conj	measurements,microscopy
R4671	T20389	T20388	prep	of,measurements
R4672	T20390	T20391	nmod	liver,levels
R4673	T20391	T20389	pobj	levels,of
R4674	T20392	T20391	nmod	triglyceride,levels
R4675	T20393	T20392	punct	(,triglyceride
R4676	T20394	T20392	appos	TAG,triglyceride
R4677	T20395	T20391	punct	),levels
R4678	T20396	T20397	punct	(,Figure
R4679	T20397	T20353	parataxis	Figure,exhibited
R4680	T20398	T20397	nummod	7,Figure
R4681	T20399	T20397	punct	),Figure
R4682	T20400	T20353	punct	.,exhibited
R4683	T20402	T20403	expl	There,were
R4684	T20404	T20405	det	no,differences
R4685	T20405	T20403	attr	differences,were
R4686	T20406	T20405	prep	in,differences
R4687	T20407	T20408	compound	plasma,triglycerides
R4688	T20408	T20406	pobj	triglycerides,in
R4689	T20409	T20408	cc	or,triglycerides
R4690	T20410	T20411	amod	free,acids
R4691	T20411	T20408	conj	acids,triglycerides
R4692	T20412	T20411	amod	fatty,acids
R4693	T20413	T20405	prep	between,differences
R4694	T20414	T20415	det	the,genotypes
R4695	T20415	T20413	pobj	genotypes,between
R4696	T20416	T20415	prep	in,genotypes
R4697	T20417	T20418	amod	fed,states
R4698	T20418	T20416	pobj	states,in
R4699	T20419	T20417	cc	or,fed
R4700	T20420	T20417	conj	fasted,fed
R4701	T20421	T20422	punct	(,data
R4702	T20422	T20403	meta	data,were
R4703	T20423	T20422	amod	unpublished,data
R4704	T20424	T20422	punct	),data
R4705	T20425	T20403	punct	.,were
R4706	T20427	T20428	aux	To,investigate
R4707	T20428	T20430	advcl	investigate,isolated
R4708	T20429	T20428	advmod	further,investigate
R4709	T20431	T20432	det	the,mechanisms
R4710	T20432	T20428	dobj	mechanisms,investigate
R4711	T20433	T20432	acl	involved,mechanisms
R4712	T20434	T20433	prep	in,involved
R4713	T20435	T20436	det	the,response
R4714	T20436	T20434	pobj	response,in
R4715	T20437	T20438	npadvmod	fasting,induced
R4716	T20438	T20436	amod	induced,response
R4717	T20439	T20438	punct	-,induced
R4718	T20440	T20436	amod	hepatic,response
R4719	T20441	T20436	amod	steatotic,response
R4720	T20442	T20430	punct	", ",isolated
R4721	T20443	T20430	nsubjpass	hepatocytes,isolated
R4722	T20444	T20430	auxpass	were,isolated
R4723	T20445	T20430	prep	from,isolated
R4724	T20446	T20447	nmod	PGC,1α
R4725	T20447	T20449	nmod	1α,mice
R4726	T20448	T20447	punct	-,1α
R4727	T20449	T20445	pobj	mice,from
R4728	T20450	T20447	punct	−,1α
R4729	T20451	T20447	punct	/,1α
R4730	T20452	T20447	punct	−,1α
R4731	T20453	T20449	cc	and,mice
R4732	T20454	T20455	compound	WT,controls
R4733	T20455	T20449	conj	controls,mice
R4734	T20456	T20430	punct	.,isolated
R4735	T20458	T20459	compound	Oleate,loading
R4736	T20459	T20460	compound	loading,experiments
R4737	T20460	T20461	nsubj	experiments,revealed
R4738	T20541	T20542	nmod	PGC,1α
R4739	T20462	T20463	mark	that,accumulated
R4740	T20542	T20544	nmod	1α,hepatocytes
R4741	T20463	T20461	ccomp	accumulated,revealed
R4742	T20543	T20542	punct	-,1α
R4743	T20544	T20540	pobj	hepatocytes,in
R4744	T20545	T20542	punct	−,1α
R4745	T20546	T20542	punct	/,1α
R4746	T20547	T20542	punct	−,1α
R4747	T20464	T20465	det	the,hepatocytes
R4748	T20548	T20549	dep	that,results
R4749	T20549	T20536	relcl	results,defect
R4750	T20550	T20549	prep	in,results
R4751	T20551	T20552	det	an,inability
R4752	T20465	T20463	nsubj	hepatocytes,accumulated
R4753	T20552	T20550	pobj	inability,in
R4754	T20466	T20467	nmod	PGC,1α
R4755	T20553	T20554	aux	to,maintain
R4756	T20467	T20465	nmod	1α,hepatocytes
R4757	T20554	T20552	acl	maintain,inability
R4758	T20555	T20556	amod	cellular,balance
R4759	T20468	T20467	punct	-,1α
R4760	T20556	T20554	dobj	balance,maintain
R4761	T20557	T20556	compound	lipid,balance
R4762	T20558	T20554	prep	in,maintain
R4763	T20469	T20467	punct	−,1α
R4764	T20559	T20560	det	the,context
R4765	T20560	T20558	pobj	context,in
R4766	T20561	T20560	prep	of,context
R4767	T20470	T20467	punct	/,1α
R4768	T20562	T20563	amod	increased,delivery
R4769	T20563	T20561	pobj	delivery,of
R4770	T20471	T20467	punct	−,1α
R4771	T20564	T20563	prep	of,delivery
R4772	T20565	T20564	pobj	lipid,of
R4773	T20472	T20473	amod	neutral,lipid
R4774	T20566	T20563	amod	such,delivery
R4775	T20567	T20568	mark	as,occurs
R4776	T20568	T20566	advcl	occurs,such
R4777	T20473	T20463	dobj	lipid,accumulated
R4778	T20569	T20568	prep	with,occurs
R4779	T20570	T20569	pobj	fasting,with
R4780	T20474	T20463	prep	to,accumulated
R4781	T20571	T20529	punct	.,indicate
R4782	T20573	T20574	nsubj	PPAR,is
R4783	T20475	T20476	det	a,extent
R4784	T20575	T20573	punct	", ",PPAR
R4785	T20576	T20577	det	a,regulator
R4786	T20476	T20474	pobj	extent,to
R4787	T20577	T20573	appos	regulator,PPAR
R4788	T20578	T20577	amod	known,regulator
R4789	T20477	T20478	advmod	significantly,greater
R4790	T20579	T20577	prep	of,regulator
R4791	T20580	T20581	amod	hepatic,enzyme
R4792	T20581	T20586	compound	enzyme,expression
R4793	T20478	T20476	amod	greater,extent
R4794	T20582	T20581	amod	mitochondrial,enzyme
R4795	T20583	T20584	amod	fatty,acid
R4796	T20584	T20585	compound	acid,oxidation
R4797	T20585	T20581	compound	oxidation,enzyme
R4798	T20586	T20579	pobj	expression,of
R4799	T20587	T20586	compound	gene,expression
R4800	T20479	T20476	prep	than,extent
R4801	T20588	T20574	punct	", ",is
R4802	T20589	T20590	det	a,target
R4803	T20590	T20574	attr	target,is
R4804	T20480	T20481	det	the,cells
R4805	T20591	T20590	prep	for,target
R4806	T20592	T20591	pobj	coactivation,for
R4807	T20593	T20592	prep	by,coactivation
R4808	T20481	T20479	pobj	cells,than
R4809	T20594	T20595	compound	PGC,1α
R4810	T20595	T20593	pobj	1α,by
R4811	T20596	T20595	punct	-,1α
R4812	T20482	T20481	compound	WT,cells
R4813	T20597	T20598	punct	[,31
R4814	T20598	T20574	parataxis	31,is
R4815	T20483	T20484	punct	(,8A
R4816	T20599	T20598	punct	],31
R4817	T20600	T20574	punct	.,is
R4818	T20484	T20463	parataxis	8A,accumulated
R4819	T20602	T20603	advmod	Therefore,sought
R4820	T20604	T20603	punct	", ",sought
R4821	T20485	T20484	compound	Figure,8A
R4822	T20605	T20603	nsubj	we,sought
R4823	T20606	T20607	aux	to,determine
R4824	T20607	T20603	xcomp	determine,sought
R4825	T20486	T20484	punct	),8A
R4826	T20608	T20609	mark	whether,related
R4827	T20609	T20607	ccomp	related,determine
R4828	T20487	T20461	punct	.,revealed
R4829	T20610	T20611	det	the,phenotype
R4830	T20611	T20609	nsubj	phenotype,related
R4831	T20612	T20611	amod	steatotic,phenotype
R4832	T20489	T20490	compound	3H,palmitate
R4833	T20613	T20611	prep	of,phenotype
R4834	T20614	T20615	det	the,mice
R4835	T20615	T20613	pobj	mice,of
R4836	T20616	T20617	nmod	PGC,1α
R4837	T20490	T20492	compound	palmitate,oxidation
R4838	T20617	T20615	nmod	1α,mice
R4839	T20618	T20617	punct	-,1α
R4840	T20491	T20490	punct	-,palmitate
R4841	T20619	T20617	punct	−,1α
R4842	T20620	T20617	punct	/,1α
R4843	T20621	T20617	punct	−,1α
R4844	T20492	T20493	compound	oxidation,rates
R4845	T20622	T20609	prep	to,related
R4846	T20623	T20624	amod	reduced,expression
R4847	T20624	T20622	pobj	expression,to
R4848	T20625	T20624	prep	of,expression
R4849	T20626	T20627	compound	PPAR,genes
R4850	T20493	T20494	nsubj	rates,were
R4851	T20627	T20625	pobj	genes,of
R4852	T20628	T20627	compound	target,genes
R4853	T20629	T20603	punct	.,sought
R4854	T20495	T20496	advmod	significantly,lower
R4855	T20631	T20632	prep	To,performed
R4856	T20633	T20634	det	this,end
R4857	T20496	T20494	acomp	lower,were
R4858	T20634	T20631	pobj	end,To
R4859	T20635	T20632	punct	", ",performed
R4860	T20636	T20637	det	a,survey
R4861	T20497	T20494	prep	in,were
R4862	T20637	T20632	nsubjpass	survey,performed
R4863	T20638	T20637	prep	of,survey
R4864	T20639	T20640	compound	candidate,genes
R4865	T20498	T20499	nmod	PGC,1α
R4866	T20499	T20501	nmod	1α,hepatocytes
R4867	T20640	T20638	pobj	genes,of
R4868	T20500	T20499	punct	-,1α
R4869	T20641	T20637	cc	and,survey
R4870	T20642	T20643	compound	gene,expression
R4871	T20501	T20497	pobj	hepatocytes,in
R4872	T20643	T20644	compound	expression,profiling
R4873	T20644	T20645	compound	profiling,experiments
R4874	T20502	T20499	punct	−,1α
R4875	T20645	T20637	conj	experiments,survey
R4876	T20646	T20632	auxpass	were,performed
R4877	T20503	T20499	punct	/,1α
R4878	T20504	T20499	punct	−,1α
R4879	T20647	T20632	punct	.,performed
R4880	T20505	T20494	prep	compared,were
R4881	T20649	T20650	advmod	Surprisingly,were
R4882	T20506	T20505	prep	to,compared
R4883	T20507	T20508	nmod	PGC,1α
R4884	T20508	T20510	nmod	1α,hepatocytes
R4885	T20651	T20650	punct	", ",were
R4886	T20509	T20508	punct	-,1α
R4887	T20652	T20653	det	the,expression
R4888	T20653	T20650	nsubj	expression,were
R4889	T20510	T20506	pobj	hepatocytes,to
R4890	T20654	T20653	amod	hepatic,expression
R4891	T20655	T20653	prep	of,expression
R4892	T20511	T20508	punct	+,1α
R4893	T20656	T20657	compound	PPAR,genes
R4894	T20657	T20655	pobj	genes,of
R4895	T20512	T20508	punct	/,1α
R4896	T20658	T20657	compound	target,genes
R4897	T20659	T20657	acl	involved,genes
R4898	T20660	T20659	prep	in,involved
R4899	T20661	T20662	amod	cellular,acid
R4900	T20662	T20660	pobj	acid,in
R4901	T20513	T20508	punct	+,1α
R4902	T20663	T20662	amod	fatty,acid
R4903	T20664	T20662	cc	and,acid
R4904	T20665	T20662	conj	oxidation,acid
R4905	T20514	T20494	prep	under,were
R4906	T20666	T20657	punct	(,genes
R4907	T20667	T20657	appos	MCPT,genes
R4908	T20668	T20667	cc	and,MCPT
R4909	T20515	T20516	amod	basal,conditions
R4910	T20669	T20667	conj	MCAD,MCPT
R4911	T20670	T20650	punct	),were
R4912	T20516	T20514	pobj	conditions,under
R4913	T20671	T20650	neg	not,were
R4914	T20672	T20673	advmod	significantly,different
R4915	T20673	T20650	acomp	different,were
R4916	T20517	T20514	cc	and,under
R4917	T20674	T20673	prep	between,different
R4918	T20675	T20676	det	the,genotypes
R4919	T20676	T20674	pobj	genotypes,between
R4920	T20518	T20514	conj	following,under
R4921	T20677	T20650	prep	under,were
R4922	T20678	T20679	amod	fed,conditions
R4923	T20679	T20677	pobj	conditions,under
R4924	T20519	T20518	pobj	exposure,following
R4925	T20680	T20678	cc	or,fed
R4926	T20681	T20678	conj	fasted,fed
R4927	T20520	T20519	prep	to,exposure
R4928	T20682	T20683	punct	(,Table
R4929	T20683	T20650	parataxis	Table,were
R4930	T20684	T20683	nummod	2,Table
R4931	T20521	T20520	pobj	oleate,to
R4932	T20685	T20683	punct	),Table
R4933	T20686	T20650	punct	.,were
R4934	T20522	T20523	punct	(,8B
R4935	T20688	T20689	advmod	Next,performed
R4936	T20523	T20494	parataxis	8B,were
R4937	T20690	T20689	punct	", ",performed
R4938	T20691	T20689	nsubj	we,performed
R4939	T20524	T20523	compound	Figure,8B
R4940	T20692	T20689	dobj	experiments,performed
R4941	T20693	T20694	aux	to,determine
R4942	T20694	T20689	advcl	determine,performed
R4943	T20525	T20523	punct	),8B
R4944	T20695	T20696	mark	whether,related
R4945	T20696	T20694	ccomp	related,determine
R4946	T20526	T20494	punct	.,were
R4947	T20697	T20698	det	the,capacity
R4948	T20698	T20696	nsubjpass	capacity,related
R4949	T20528	T20529	advcl	Taken,indicate
R4950	T20699	T20698	amod	reduced,capacity
R4951	T20700	T20698	prep	for,capacity
R4952	T20701	T20702	compound	fat,oxidation
R4953	T20702	T20700	pobj	oxidation,for
R4954	T20530	T20528	advmod	together,Taken
R4955	T20703	T20698	prep	in,capacity
R4956	T20704	T20705	det	the,hepatocytes
R4957	T20705	T20703	pobj	hepatocytes,in
R4958	T20706	T20705	prep	of,hepatocytes
R4959	T20707	T20708	det	the,mice
R4960	T20531	T20529	punct	", ",indicate
R4961	T20708	T20706	pobj	mice,of
R4962	T20709	T20710	nmod	PGC,1α
R4963	T20710	T20708	nmod	1α,mice
R4964	T20532	T20533	det	these,results
R4965	T20711	T20710	punct	-,1α
R4966	T20712	T20710	punct	−,1α
R4967	T20713	T20710	punct	/,1α
R4968	T20533	T20529	nsubj	results,indicate
R4969	T20714	T20710	punct	−,1α
R4970	T20715	T20696	auxpass	was,related
R4971	T20716	T20696	prep	to,related
R4972	T20534	T20533	amod	latter,results
R4973	T20717	T20718	amod	altered,function
R4974	T20718	T20716	pobj	function,to
R4975	T20535	T20536	det	a,defect
R4976	T20719	T20718	amod	mitochondrial,function
R4977	T20720	T20718	amod	respiratory,function
R4978	T20721	T20689	punct	.,performed
R4979	T20536	T20529	dobj	defect,indicate
R4980	T20723	T20724	prep	Compared,exhibited
R4981	T20537	T20538	npadvmod	cell,autonomous
R4982	T20725	T20723	prep	to,Compared
R4983	T20726	T20727	det	the,controls
R4984	T20538	T20536	amod	autonomous,defect
R4985	T20539	T20538	punct	-,autonomous
R4986	T20727	T20725	pobj	controls,to
R4987	T20540	T20536	prep	in,defect
R4988	T20728	T20727	compound	WT,controls
R4989	T20729	T20724	punct	", ",exhibited
R4990	T20753	T20752	compound	Figure,8C
R4991	T20730	T20731	nmod	PGC,1α
R4992	T20731	T20733	nmod	1α,hepatocytes
R4993	T20732	T20731	punct	-,1α
R4994	T20754	T20752	punct	),8C
R4995	T20733	T20724	nsubj	hepatocytes,exhibited
R4996	T20734	T20731	punct	−,1α
R4997	T20755	T20724	punct	.,exhibited
R4998	T20735	T20731	punct	/,1α
R4999	T20736	T20731	punct	−,1α
R5000	T20737	T20738	det	a,reduction
R5001	T20757	T20758	det	These,results
R5002	T20738	T20724	dobj	reduction,exhibited
R5003	T20739	T20738	amod	modest,reduction
R5004	T20740	T20739	cc	but,modest
R5005	T20741	T20739	conj	significant,modest
R5006	T20742	T20738	prep	in,reduction
R5007	T20743	T20744	preconj	both,state
R5008	T20758	T20759	nsubj	results,identify
R5009	T20744	T20745	nmod	state,rates
R5010	T20745	T20742	pobj	rates,in
R5011	T20746	T20744	nummod	2,state
R5012	T20760	T20761	nummod	one,mechanism
R5013	T20747	T20744	cc	and,state
R5014	T20748	T20744	conj	state,state
R5015	T20749	T20748	nummod	3,state
R5016	T20750	T20745	compound	respiration,rates
R5017	T20761	T20759	dobj	mechanism,identify
R5018	T20751	T20752	punct	(,8C
R5019	T20752	T20724	parataxis	8C,exhibited
R5020	T20762	T20761	amod	potential,mechanism
R5021	T20763	T20761	amod	responsible,mechanism
R5022	T20764	T20763	prep	for,responsible
R5023	T20858	T20855	punct	(,desaturase
R5024	T20859	T20855	appos	SCD1,desaturase
R5025	T20765	T20766	det	the,steatosis
R5026	T20860	T20837	punct	),abolished
R5027	T20861	T20837	punct	", ",abolished
R5028	T20766	T20764	pobj	steatosis,for
R5029	T20862	T20837	auxpass	was,abolished
R5030	T20863	T20837	prep	in,abolished
R5031	T20864	T20865	nmod	PGC,1α
R5032	T20767	T20768	npadvmod	fasting,induced
R5033	T20865	T20867	nmod	1α,mice
R5034	T20866	T20865	punct	-,1α
R5035	T20867	T20863	pobj	mice,in
R5036	T20768	T20766	amod	induced,steatosis
R5037	T20868	T20865	punct	−,1α
R5038	T20869	T20865	punct	/,1α
R5039	T20769	T20768	punct	-,induced
R5040	T20870	T20865	punct	−,1α
R5041	T20871	T20872	punct	(,Table
R5042	T20872	T20837	parataxis	Table,abolished
R5043	T20770	T20766	amod	hepatic,steatosis
R5044	T20873	T20872	nummod	2,Table
R5045	T20874	T20872	punct	),Table
R5046	T20875	T20837	punct	.,abolished
R5047	T20771	T20761	punct	: ,mechanism
R5048	T20877	T20878	advmod	Furthermore,activated
R5049	T20772	T20773	amod	reduced,capacity
R5050	T20879	T20878	punct	", ",activated
R5051	T20880	T20878	nsubjpass	expression,activated
R5052	T20773	T20761	appos	capacity,mechanism
R5053	T20881	T20880	prep	of,expression
R5054	T20882	T20883	det	the,gene
R5055	T20883	T20881	pobj	gene,of
R5056	T20884	T20883	acl	encoding,gene
R5057	T20885	T20886	compound	diglyceride,acyltransferase
R5058	T20774	T20773	prep	for,capacity
R5059	T20886	T20884	dobj	acyltransferase,encoding
R5060	T20887	T20886	punct	(,acyltransferase
R5061	T20888	T20886	appos	DGAT,acyltransferase
R5062	T20775	T20776	compound	fat,oxidation
R5063	T20889	T20886	punct	),acyltransferase
R5064	T20890	T20886	punct	", ",acyltransferase
R5065	T20891	T20892	dep	which,catalyzes
R5066	T20776	T20774	pobj	oxidation,for
R5067	T20892	T20886	relcl	catalyzes,acyltransferase
R5068	T20893	T20894	det	the,step
R5069	T20894	T20892	dobj	step,catalyzes
R5070	T20777	T20773	prep	due,capacity
R5071	T20895	T20894	amod	last,step
R5072	T20896	T20894	prep	in,step
R5073	T20778	T20777	pcomp	to,due
R5074	T20897	T20898	compound	TAG,synthesis
R5075	T20779	T20780	amod	mitochondrial,dysfunction
R5076	T20898	T20896	pobj	synthesis,in
R5077	T20899	T20878	punct	", ",activated
R5078	T20780	T20777	pobj	dysfunction,due
R5079	T20900	T20878	auxpass	was,activated
R5080	T20901	T20878	prep	at,activated
R5081	T20902	T20901	pobj	baseline,at
R5082	T20781	T20780	amod	respiratory,dysfunction
R5083	T20903	T20878	cc	and,activated
R5084	T20904	T20878	conj	induced,activated
R5085	T20905	T20904	agent	by,induced
R5086	T20782	T20759	punct	.,identify
R5087	T20906	T20905	pobj	fasting,by
R5088	T20907	T20904	prep	to,induced
R5089	T20784	T20785	mark	Although,reveal
R5090	T20908	T20909	det	a,level
R5091	T20909	T20907	pobj	level,to
R5092	T20910	T20909	amod	greater,level
R5093	T20911	T20904	prep	in,induced
R5094	T20785	T20794	advcl	reveal,noted
R5095	T20912	T20913	nmod	PGC,1α
R5096	T20913	T20915	nmod	1α,mice
R5097	T20914	T20913	punct	-,1α
R5098	T20915	T20911	pobj	mice,in
R5099	T20786	T20787	det	the,studies
R5100	T20916	T20913	punct	−,1α
R5101	T20917	T20913	punct	/,1α
R5102	T20787	T20785	nsubj	studies,reveal
R5103	T20918	T20913	punct	−,1α
R5104	T20919	T20920	punct	(,Table
R5105	T20920	T20904	parataxis	Table,induced
R5106	T20921	T20920	nummod	2,Table
R5107	T20922	T20920	punct	),Table
R5108	T20923	T20878	punct	.,activated
R5109	T20788	T20789	compound	liver,gene
R5110	T20925	T20926	det	These,results
R5111	T20926	T20927	nsubj	results,suggest
R5112	T20789	T20790	compound	gene,profiling
R5113	T20928	T20929	mark	that,activated
R5114	T20790	T20787	compound	profiling,studies
R5115	T20929	T20927	ccomp	activated,suggest
R5116	T20930	T20929	punct	", ",activated
R5117	T20931	T20929	prep	in,activated
R5118	T20932	T20931	pobj	addition,in
R5119	T20791	T20790	compound	expression,profiling
R5120	T20933	T20932	prep	to,addition
R5121	T20934	T20935	det	a,defect
R5122	T20935	T20933	pobj	defect,to
R5123	T20792	T20785	aux	did,reveal
R5124	T20936	T20935	prep	in,defect
R5125	T20937	T20936	pobj	oxidation,in
R5126	T20793	T20785	neg	not,reveal
R5127	T20938	T20929	punct	", ",activated
R5128	T20939	T20929	nsubjpass	components,activated
R5129	T20940	T20939	prep	of,components
R5130	T20795	T20785	dobj	abnormalities,reveal
R5131	T20941	T20942	det	the,pathway
R5132	T20942	T20940	pobj	pathway,of
R5133	T20943	T20944	compound	TAG,synthesis
R5134	T20944	T20942	compound	synthesis,pathway
R5135	T20945	T20929	auxpass	are,activated
R5136	T20796	T20795	prep	in,abnormalities
R5137	T20946	T20929	prep	in,activated
R5138	T20947	T20948	det	the,mice
R5139	T20948	T20946	pobj	mice,in
R5140	T20797	T20798	det	the,pathway
R5141	T20949	T20950	nmod	PGC,1α
R5142	T20950	T20948	nmod	1α,mice
R5143	T20951	T20950	punct	-,1α
R5144	T20798	T20796	pobj	pathway,in
R5145	T20952	T20950	punct	−,1α
R5146	T20953	T20950	punct	/,1α
R5147	T20954	T20950	punct	−,1α
R5148	T20799	T20800	amod	fatty,acid
R5149	T20955	T20927	punct	.,suggest
R5150	T20957	T20958	aux	To,evaluate
R5151	T20800	T20801	compound	acid,oxidation
R5152	T20958	T20959	advcl	evaluate,determined
R5153	T20960	T20961	det	this,possibility
R5154	T20801	T20798	compound	oxidation,pathway
R5155	T20961	T20958	dobj	possibility,evaluate
R5156	T20962	T20958	advmod	directly,evaluate
R5157	T20802	T20785	prep	in,reveal
R5158	T20803	T20804	det	the,mice
R5159	T20963	T20959	punct	", ",determined
R5160	T20964	T20959	nsubjpass	rates,determined
R5161	T20965	T20964	prep	of,rates
R5162	T20804	T20802	pobj	mice,in
R5163	T20966	T20967	compound	3H,glycerol
R5164	T20967	T20969	compound	glycerol,incorporation
R5165	T20968	T20967	punct	-,glycerol
R5166	T20805	T20806	nmod	PGC,1α
R5167	T20969	T20965	pobj	incorporation,of
R5168	T20970	T20969	prep	into,incorporation
R5169	T20806	T20804	nmod	1α,mice
R5170	T20971	T20970	pobj	TAG,into
R5171	T20972	T20959	auxpass	were,determined
R5172	T20973	T20959	prep	in,determined
R5173	T20974	T20975	amod	isolated,hepatocytes
R5174	T20807	T20806	punct	-,1α
R5175	T20975	T20973	pobj	hepatocytes,in
R5176	T20976	T20959	punct	.,determined
R5177	T20808	T20806	punct	−,1α
R5178	T20978	T20979	compound	3H,TAG
R5179	T20979	T20981	compound	TAG,incorporation
R5180	T20809	T20806	punct	/,1α
R5181	T20980	T20979	punct	-,TAG
R5182	T20981	T20982	nsubjpass	incorporation,increased
R5183	T20810	T20806	punct	−,1α
R5184	T20983	T20982	auxpass	was,increased
R5185	T20811	T20794	punct	", ",noted
R5186	T20984	T20985	advmod	nearly,50
R5187	T20985	T20986	nummod	50,%
R5188	T20812	T20813	amod	several,differences
R5189	T20986	T20982	npadvmod	%,increased
R5190	T20987	T20982	prep	in,increased
R5191	T20988	T20987	pobj	hepatocytes,in
R5192	T20813	T20794	nsubjpass	differences,noted
R5193	T20989	T20988	acl	isolated,hepatocytes
R5194	T20990	T20989	prep	from,isolated
R5195	T20991	T20992	nmod	PGC,1α
R5196	T20814	T20813	amod	interesting,differences
R5197	T20992	T20994	nmod	1α,mice
R5199	T20815	T20813	prep	in,differences
R5200	T20994	T20990	pobj	mice,from
R5201	T20995	T20992	punct	−,1α
R5202	T20996	T20992	punct	/,1α
R5203	T20816	T20817	det	the,activity
R5204	T20997	T20992	punct	−,1α
R5205	T20998	T20982	prep	compared,increased
R5206	T20999	T20998	prep	to,compared
R5207	T20817	T20815	pobj	activity,in
R5208	T21000	T21001	nmod	PGC,1α
R5209	T21001	T21003	nmod	1α,controls
R5210	T21002	T21001	punct	-,1α
R5211	T21003	T20999	pobj	controls,to
R5212	T21004	T21001	punct	+,1α
R5213	T20818	T20817	prep	of,activity
R5214	T21005	T21001	punct	/,1α
R5215	T21006	T21001	punct	+,1α
R5216	T21007	T21008	punct	(,8D
R5217	T21008	T20982	parataxis	8D,increased
R5218	T20819	T20820	det	the,pathway
R5219	T21009	T21008	compound	Figure,8D
R5220	T20820	T20818	pobj	pathway,of
R5221	T21010	T21008	punct	),8D
R5222	T21011	T20982	punct	", ",increased
R5223	T21012	T20982	advcl	confirming,increased
R5224	T21013	T21014	mark	that,increased
R5225	T21014	T21012	ccomp	increased,confirming
R5226	T20821	T20822	nmod	sterol,protein
R5227	T21015	T21016	compound	TAG,synthesis
R5228	T21016	T21017	compound	synthesis,rates
R5229	T21017	T21014	nsubjpass	rates,increased
R5230	T20822	T20826	nmod	protein,1c
R5231	T21018	T21014	auxpass	are,increased
R5232	T21019	T21014	prep	in,increased
R5233	T21020	T21021	compound	PGC,1α
R5234	T20823	T20822	amod	regulatory,protein
R5235	T21021	T21023	npadvmod	1α,null
R5236	T21022	T21021	punct	-,1α
R5237	T21023	T21024	amod	null,hepatocytes
R5238	T20824	T20822	nmod	element,protein
R5239	T21024	T21019	pobj	hepatocytes,in
R5240	T21025	T21014	punct	", ",increased
R5241	T21026	T21014	advcl	identifying,increased
R5242	T20825	T20822	nmod	binding,protein
R5243	T21027	T21028	det	a,mechanism
R5244	T21028	T21026	dobj	mechanism,identifying
R5245	T21029	T21028	amod	second,mechanism
R5246	T20826	T20820	nmod	1c,pathway
R5247	T21030	T21028	amod	potential,mechanism
R5248	T21031	T21028	acl	contributing,mechanism
R5249	T21032	T21031	prep	to,contributing
R5250	T20827	T20826	punct	-,1c
R5251	T21033	T21034	det	the,steatosis
R5252	T21034	T21032	pobj	steatosis,to
R5253	T20828	T20826	punct	(,1c
R5254	T20829	T20830	compound	SREBP,1c
R5255	T21035	T21036	npadvmod	fasting,induced
R5256	T20830	T20826	appos	1c,1c
R5257	T21036	T21034	amod	induced,steatosis
R5258	T21037	T21036	punct	-,induced
R5259	T20831	T20830	punct	-,1c
R5260	T21038	T21034	amod	hepatic,steatosis
R5261	T21039	T20982	punct	.,increased
R5262	T20832	T20820	punct	),pathway
R5263	T20833	T20794	auxpass	were,noted
R5264	T20834	T20794	punct	.,noted
R5265	T20836	T20837	advmod	Specifically,abolished
R5266	T20838	T20837	punct	", ",abolished
R5267	T20839	T20840	det	the,regulation
R5268	T20840	T20837	nsubjpass	regulation,abolished
R5269	T20841	T20842	npadvmod	fasting,mediated
R5270	T20842	T20840	amod	mediated,regulation
R5271	T20843	T20842	punct	-,mediated
R5272	T20844	T20840	compound	down,regulation
R5273	T20845	T20840	punct	-,regulation
R5274	T20846	T20840	prep	of,regulation
R5275	T20847	T20848	compound	SREBP,1c
R5276	T20848	T20846	pobj	1c,of
R5277	T20849	T20848	punct	-,1c
R5278	T20850	T20848	cc	and,1c
R5279	T20851	T20852	poss	its,gene
R5280	T20852	T20848	conj	gene,1c
R5281	T20853	T20852	compound	target,gene
R5282	T20854	T20855	compound	stearoyl,desaturase
R5283	T20855	T20852	appos	desaturase,gene
R5284	T20856	T20855	punct	-,desaturase
R5285	T20857	T20855	compound	CoA,desaturase
R5286	T22539	T22540	prep	Despite,Exhibit
R5287	T22541	T22542	det	a,Phenotype
R5288	T22542	T22539	pobj	Phenotype,Despite
R5289	T22543	T22544	amod	Mild,Obese
R5290	T22544	T22542	amod	Obese,Phenotype
R5291	T22545	T22540	punct	", ",Exhibit
R5292	T22546	T22547	amod	Female,Mice
R5293	T22547	T22540	nsubj	Mice,Exhibit
R5294	T22548	T22549	nmod	PGC,1α
R5295	T22549	T22547	nmod	1α,Mice
R5296	T22550	T22549	punct	-,1α
R5297	T22551	T22549	punct	−,1α
R5298	T22552	T22549	punct	/,1α
R5299	T22553	T22549	punct	−,1α
R5300	T22554	T22540	aux	Do,Exhibit
R5301	T22555	T22540	neg	Not,Exhibit
R5302	T22556	T22557	compound	Insulin,Resistance
R5303	T22557	T22540	dobj	Resistance,Exhibit
R5304	T22559	T22560	amod	Recent,studies
R5305	T22560	T22561	nsubj	studies,suggested
R5306	T22562	T22561	aux	have,suggested
R5307	T22563	T22564	mark	that,influence
R5308	T22564	T22561	advcl	influence,suggested
R5309	T22565	T22566	amod	specific,1α
R5310	T22566	T22564	nsubj	1α,influence
R5311	T22567	T22566	compound	PGC,1α
R5312	T22568	T22566	punct	-,1α
R5313	T22569	T22570	amod	single,nucleotide
R5314	T22570	T22571	compound	nucleotide,polymorphisms
R5315	T22571	T22566	appos	polymorphisms,1α
R5316	T22572	T22571	cc	and,polymorphisms
R5317	T22573	T22571	conj	haplotypes,polymorphisms
R5318	T22574	T22564	aux	may,influence
R5319	T22575	T22576	det	the,development
R5320	T22576	T22564	dobj	development,influence
R5321	T22577	T22576	prep	of,development
R5322	T22578	T22579	compound	insulin,resistance
R5323	T22579	T22577	pobj	resistance,of
R5324	T22580	T22579	cc	and,resistance
R5325	T22581	T22579	conj	diabetes,resistance
R5326	T22582	T22583	punct	[,30
R5327	T22583	T22564	parataxis	30,influence
R5328	T22584	T22583	nummod	27,30
R5329	T22585	T22583	punct	",",30
R5330	T22586	T22583	punct	],30
R5331	T22587	T22564	cc	and,influence
R5332	T22588	T22589	mark	that,diminished
R5333	T22589	T22564	conj	diminished,influence
R5334	T22590	T22591	nmod	PGC,activity
R5335	T22591	T22589	nsubjpass	activity,diminished
R5336	T22592	T22590	punct	-,PGC
R5337	T22593	T22590	nummod	1,PGC
R5338	T22594	T22589	auxpass	is,diminished
R5339	T22595	T22589	prep	in,diminished
R5340	T22596	T22597	npadvmod	insulin,resistant
R5341	T22597	T22599	amod	resistant,muscle
R5342	T22598	T22597	punct	-,resistant
R5343	T22599	T22595	pobj	muscle,in
R5344	T22600	T22597	cc	and,resistant
R5345	T22601	T22597	conj	diabetic,resistant
R5346	T22602	T22603	punct	[,23
R5347	T22603	T22589	parataxis	23,diminished
R5348	T22604	T22603	nummod	22,23
R5349	T22605	T22603	punct	",",23
R5350	T22606	T22603	punct	],23
R5351	T22607	T22561	punct	.,suggested
R5352	T22609	T22610	advmod	Accordingly,examined
R5353	T22611	T22610	punct	", ",examined
R5354	T22612	T22613	amod	peripheral,disposal
R5355	T22613	T22610	nsubjpass	disposal,examined
R5356	T22614	T22613	compound	glucose,disposal
R5357	T22615	T22613	cc	and,disposal
R5358	T22616	T22617	compound	insulin,responsiveness
R5359	T22617	T22613	conj	responsiveness,disposal
R5360	T22618	T22610	auxpass	were,examined
R5361	T22619	T22610	prep	in,examined
R5362	T22620	T22621	nmod	PGC,1α
R5363	T22621	T22623	nmod	1α,mice
R5364	T22622	T22621	punct	-,1α
R5365	T22623	T22619	pobj	mice,in
R5366	T22624	T22621	punct	−,1α
R5367	T22625	T22621	punct	/,1α
R5368	T22626	T22621	punct	−,1α
R5369	T22627	T22610	punct	.,examined
R5370	T22629	T22630	compound	Glucose,tolerance
R5371	T22630	T22631	compound	tolerance,testing
R5372	T22631	T22632	nsubj	testing,revealed
R5373	T22633	T22631	prep	of,testing
R5374	T22634	T22635	nummod	2,mo
R5375	T22635	T22637	npadvmod	mo,old
R5376	T22636	T22635	punct	-,mo
R5377	T22637	T22639	amod	old,mice
R5378	T22638	T22637	punct	-,old
R5379	T22639	T22633	pobj	mice,of
R5380	T22640	T22639	amod	male,mice
R5381	T22641	T22640	cc	and,male
R5382	T22642	T22640	conj	female,male
R5383	T22643	T22644	det	no,difference
R5384	T22644	T22632	dobj	difference,revealed
R5385	T22645	T22644	amod	significant,difference
R5386	T22646	T22644	prep	in,difference
R5387	T22647	T22648	compound	blood,glucose
R5388	T22648	T22649	compound	glucose,excursion
R5389	T22649	T22646	pobj	excursion,in
R5390	T22650	T22644	prep	between,difference
R5391	T22651	T22652	nmod	PGC,1α
R5392	T22652	T22654	nmod	1α,groups
R5393	T22653	T22652	punct	-,1α
R5394	T22654	T22650	pobj	groups,between
R5395	T22655	T22652	punct	+,1α
R5396	T22656	T22652	punct	/,1α
R5397	T22657	T22652	punct	+,1α
R5398	T22658	T22652	cc	and,1α
R5399	T22659	T22660	compound	PGC,1α
R5400	T22660	T22652	conj	1α,1α
R5401	T22661	T22660	punct	-,1α
R5402	T22662	T22660	punct	−,1α
R5403	T22663	T22660	punct	/,1α
R5404	T22664	T22660	punct	−,1α
R5405	T22665	T22666	punct	(,data
R5406	T22666	T22632	meta	data,revealed
R5407	T22667	T22666	amod	unpublished,data
R5408	T22668	T22666	punct	),data
R5409	T22669	T22632	punct	.,revealed
R5410	T22671	T22672	prep	Given,evaluated
R5411	T22673	T22674	mark	that,develop
R5412	T22674	T22671	pcomp	develop,Given
R5413	T22675	T22676	amod	older,mice
R5414	T22676	T22674	nsubj	mice,develop
R5415	T22677	T22676	amod	female,mice
R5416	T22678	T22679	nmod	PGC,1α
R5417	T22679	T22676	nmod	1α,mice
R5418	T22680	T22679	punct	-,1α
R5419	T22681	T22679	punct	−,1α
R5420	T22682	T22679	punct	/,1α
R5421	T22683	T22679	punct	−,1α
R5422	T22684	T22685	det	an,increase
R5423	T22685	T22674	dobj	increase,develop
R5424	T22686	T22685	prep	in,increase
R5425	T22687	T22688	compound	body,fat
R5426	T22688	T22689	compound	fat,stores
R5427	T22689	T22686	pobj	stores,in
R5428	T22690	T22672	punct	", ",evaluated
R5429	T22691	T22692	compound	glucose,tolerance
R5430	T22692	T22672	nsubjpass	tolerance,evaluated
R5431	T22693	T22692	cc	and,tolerance
R5432	T22694	T22695	compound	insulin,responsiveness
R5433	T22695	T22692	conj	responsiveness,tolerance
R5434	T22696	T22672	auxpass	were,evaluated
R5435	T22697	T22672	advmod	further,evaluated
R5436	T22698	T22672	prep	in,evaluated
R5437	T22699	T22700	det	this,group
R5438	T22700	T22698	pobj	group,in
R5439	T22701	T22672	punct	.,evaluated
R5440	T22703	T22704	compound	Glucose,tolerance
R5441	T22704	T22705	compound	tolerance,testing
R5442	T22705	T22706	nsubj	testing,revealed
R5443	T22707	T22705	prep	in,testing
R5444	T22708	T22709	nummod	4.5,mo
R5445	T22709	T22711	npadvmod	mo,old
R5446	T22710	T22709	punct	-,mo
R5447	T22711	T22713	amod	old,mice
R5448	T22712	T22711	punct	-,old
R5449	T22713	T22707	pobj	mice,in
R5450	T22714	T22713	amod	female,mice
R5451	T22715	T22716	nmod	PGC,1α
R5452	T22716	T22713	nmod	1α,mice
R5453	T22717	T22716	punct	-,1α
R5454	T22718	T22716	punct	−,1α
R5455	T22719	T22716	punct	/,1α
R5456	T22720	T22716	punct	−,1α
R5457	T22721	T22722	mark	that,exhibited
R5458	T22722	T22706	ccomp	exhibited,revealed
R5459	T22723	T22722	punct	", ",exhibited
R5460	T22724	T22722	prep	despite,exhibited
R5461	T22725	T22726	amod	increased,weight
R5462	T22726	T22724	pobj	weight,despite
R5463	T22727	T22726	compound	body,weight
R5464	T22728	T22729	punct	[,g
R5465	T22729	T22726	parataxis	g,weight
R5466	T22730	T22731	nmod	mean,weight
R5467	T22731	T22741	nsubj	weight,g
R5468	T22732	T22730	punct	±,mean
R5469	T22733	T22734	amod	standard,error
R5470	T22734	T22730	appos	error,mean
R5471	T22735	T22734	prep	of,error
R5472	T22736	T22737	det	the,mean
R5473	T22737	T22735	pobj	mean,of
R5474	T22738	T22734	punct	(,error
R5475	T22739	T22734	appos	SEM,error
R5476	T22740	T22731	punct	),weight
R5477	T22741	T22729	ccomp	g,g
R5478	T22742	T22731	prep	of,weight
R5479	T22743	T22744	nmod	PGC,1α
R5480	T22744	T22746	nmod	1α,mice
R5481	T22745	T22743	punct	-,PGC
R5482	T22746	T22742	pobj	mice,of
R5483	T22747	T22744	punct	+,1α
R5484	T22748	T22744	punct	/,1α
R5485	T22749	T22744	punct	+,1α
R5486	T22750	T22741	punct	=,g
R5487	T22751	T22752	quantmod	22.4,0.79
R5488	T22752	T22741	nummod	0.79,g
R5489	T22753	T22752	punct	±,0.79
R5490	T22754	T22729	punct	;,g
R5491	T22755	T22756	nmod	PGC,1α
R5492	T22756	T22758	nmod	1α,mice
R5493	T22757	T22756	punct	-,1α
R5494	T22758	T22729	dep	mice,g
R5495	T22759	T22756	punct	−,1α
R5496	T22760	T22756	punct	/,1α
R5497	T22761	T22756	punct	−,1α
R5498	T22762	T22729	punct	=,g
R5499	T22763	T22764	quantmod	25.2,1.04
R5500	T22764	T22729	nummod	1.04,g
R5501	T22765	T22764	punct	±,1.04
R5502	T22766	T22722	punct	),exhibited
R5503	T22767	T22722	punct	", ",exhibited
R5504	T22768	T22769	nmod	PGC,1α
R5505	T22769	T22771	nmod	1α,mice
R5506	T22770	T22769	punct	-,1α
R5507	T22771	T22722	nsubj	mice,exhibited
R5508	T22772	T22769	punct	−,1α
R5509	T22773	T22769	punct	/,1α
R5510	T22774	T22769	punct	−,1α
R5511	T22775	T22776	amod	similar,levels
R5512	T22776	T22722	dobj	levels,exhibited
R5513	T22777	T22776	prep	of,levels
R5514	T22778	T22779	compound	glucose,tolerance
R5515	T22779	T22777	pobj	tolerance,of
R5516	T22780	T22776	prep	compared,levels
R5517	T22781	T22780	prep	to,compared
R5518	T22782	T22783	compound	WT,mice
R5519	T22783	T22781	pobj	mice,to
R5520	T22784	T22783	prep	on,mice
R5521	T22785	T22786	amod	standard,chow
R5522	T22786	T22784	pobj	chow,on
R5523	T22787	T22786	compound	rodent,chow
R5524	T22788	T22789	punct	(,Figure
R5525	T22789	T22722	parataxis	Figure,exhibited
R5526	T22790	T22789	nummod	9,Figure
R5527	T22791	T22789	punct	),Figure
R5528	T22792	T22706	punct	.,revealed
R5529	T22794	T22795	aux	To,examine
R5530	T22795	T22796	advcl	examine,placed
R5531	T22797	T22798	compound	glucose,homeostasis
R5532	T22798	T22795	dobj	homeostasis,examine
R5533	T22799	T22798	prep	in,homeostasis
R5534	T22800	T22799	pobj	response,in
R5535	T22801	T22800	prep	to,response
R5536	T22802	T22803	amod	high,fat
R5537	T22803	T22805	compound	fat,diet
R5538	T22804	T22803	punct	-,fat
R5539	T22805	T22801	pobj	diet,to
R5540	T22806	T22796	punct	", ",placed
R5541	T22807	T22808	amod	female,mice
R5542	T22808	T22796	nsubjpass	mice,placed
R5543	T22809	T22810	nmod	PGC,1α
R5544	T22810	T22808	nmod	1α,mice
R5545	T22811	T22810	punct	-,1α
R5546	T22812	T22810	punct	+,1α
R5547	T22813	T22810	punct	/,1α
R5548	T22814	T22810	punct	+,1α
R5549	T22815	T22810	cc	and,1α
R5550	T22816	T22817	compound	PGC,1α
R5551	T22817	T22810	conj	1α,1α
R5552	T22818	T22817	punct	-,1α
R5553	T22819	T22817	punct	−,1α
R5554	T22820	T22817	punct	/,1α
R5555	T22821	T22817	punct	−,1α
R5556	T22822	T22796	auxpass	were,placed
R5557	T22823	T22796	prep	on,placed
R5558	T22824	T22825	amod	high,fat
R5559	T22825	T22827	compound	fat,chow
R5560	T22826	T22825	punct	-,fat
R5561	T22827	T22823	pobj	chow,on
R5562	T22828	T22829	punct	(,calories
R5563	T22829	T22796	parataxis	calories,placed
R5564	T22830	T22831	nummod	43,%
R5565	T22831	T22829	compound	%,calories
R5566	T22832	T22829	prep	from,calories
R5567	T22833	T22832	pobj	fat,from
R5568	T22834	T22829	punct	),calories
R5569	T22835	T22796	prep	for,placed
R5570	T22836	T22837	nummod	6,wk
R5571	T22837	T22835	pobj	wk,for
R5572	T22838	T22796	advcl	starting,placed
R5573	T22839	T22838	prep	at,starting
R5574	T22840	T22841	nummod	8,wk
R5575	T22841	T22839	pobj	wk,at
R5576	T22842	T22841	prep	of,wk
R5577	T22843	T22842	pobj	age,of
R5578	T22844	T22796	punct	.,placed
R5579	T22846	T22847	det	The,weight
R5580	T22847	T22848	nsubj	weight,was
R5581	T22849	T22847	acl	gained,weight
R5582	T22850	T22849	prep	on,gained
R5583	T22851	T22852	det	the,diet
R5584	T22852	T22850	pobj	diet,on
R5585	T22853	T22854	amod	high,fat
R5586	T22854	T22852	compound	fat,diet
R5587	T22855	T22854	punct	-,fat
R5588	T22856	T22848	acomp	similar,was
R5589	T22857	T22848	prep	for,was
R5590	T22858	T22859	det	the,groups
R5591	T22859	T22857	pobj	groups,for
R5592	T22860	T22861	nmod	PGC,1α
R5593	T22861	T22859	nmod	1α,groups
R5594	T22862	T22861	punct	-,1α
R5595	T22863	T22861	punct	+,1α
R5596	T22864	T22861	punct	/,1α
R5597	T22865	T22861	punct	+,1α
R5598	T22866	T22861	cc	and,1α
R5599	T22867	T22868	compound	PGC,1α
R5600	T22868	T22861	conj	1α,1α
R5601	T22869	T22868	punct	-,1α
R5602	T22870	T22868	punct	−,1α
R5603	T22871	T22868	punct	/,1α
R5604	T22872	T22868	punct	−,1α
R5605	T22873	T22874	punct	(,S3
R5606	T22874	T22848	parataxis	S3,was
R5607	T22875	T22874	compound	Figure,S3
R5608	T22876	T22874	punct	),S3
R5609	T22877	T22848	punct	.,was
R5610	T22879	T22880	advmod	Surprisingly,were
R5611	T22881	T22880	punct	", ",were
R5612	T22882	T22883	det	the,mice
R5613	T22883	T22880	nsubj	mice,were
R5614	T22884	T22885	nmod	PGC,1α
R5615	T22885	T22883	nmod	1α,mice
R5616	T22886	T22885	punct	-,1α
R5617	T22887	T22885	punct	−,1α
R5618	T22888	T22885	punct	/,1α
R5619	T22889	T22885	punct	−,1α
R5620	T22890	T22883	prep	on,mice
R5621	T22891	T22892	det	a,diet
R5622	T22892	T22890	pobj	diet,on
R5623	T22893	T22894	amod	high,fat
R5624	T22894	T22892	compound	fat,diet
R5625	T22895	T22894	punct	-,fat
R5626	T22896	T22897	advmod	significantly,more
R5627	T22897	T22898	advmod	more,tolerant
R5628	T22898	T22880	acomp	tolerant,were
R5629	T22899	T22898	npadvmod	glucose,tolerant
R5630	T22900	T22898	punct	-,tolerant
R5631	T22901	T22898	cc	and,tolerant
R5632	T22902	T22903	npadvmod	insulin,sensitive
R5633	T22903	T22898	conj	sensitive,tolerant
R5634	T22904	T22903	punct	-,sensitive
R5635	T22905	T22880	prep	compared,were
R5636	T22906	T22905	prep	to,compared
R5637	T22907	T22908	det	the,mice
R5638	T22908	T22906	pobj	mice,to
R5639	T22909	T22910	nmod	PGC,1α
R5640	T22910	T22908	nmod	1α,mice
R5641	T22911	T22910	punct	-,1α
R5642	T22912	T22910	punct	+,1α
R5643	T22913	T22910	punct	/,1α
R5644	T22914	T22910	punct	+,1α
R5645	T22915	T22916	punct	(,9B
R5646	T22916	T22880	parataxis	9B,were
R5647	T22917	T22916	compound	Figure,9B
R5648	T22918	T22916	punct	),9B
R5649	T22919	T22880	punct	.,were
R5650	T22921	T22922	advcl	Taken,indicate
R5651	T22923	T22921	advmod	together,Taken
R5652	T22924	T22922	punct	", ",indicate
R5653	T22925	T22926	det	these,results
R5654	T22926	T22922	nsubj	results,indicate
R5655	T22927	T22928	mark	that,exhibit
R5656	T22928	T22922	ccomp	exhibit,indicate
R5657	T22929	T22928	punct	", ",exhibit
R5658	T22930	T22928	prep	despite,exhibit
R5659	T22931	T22932	amod	excess,fat
R5660	T22932	T22930	pobj	fat,despite
R5661	T22933	T22932	compound	body,fat
R5662	T22934	T22932	prep	under,fat
R5663	T22935	T22936	amod	standard,conditions
R5664	T22936	T22934	pobj	conditions,under
R5665	T22937	T22928	punct	", ",exhibit
R5666	T22938	T22939	det	the,mice
R5667	T22939	T22928	nsubj	mice,exhibit
R5668	T22940	T22939	amod	female,mice
R5669	T22941	T22942	nmod	PGC,1α
R5670	T22942	T22939	nmod	1α,mice
R5671	T22943	T22942	punct	-,1α
R5672	T22944	T22942	punct	−,1α
R5673	T22945	T22942	punct	/,1α
R5674	T22946	T22942	punct	−,1α
R5675	T22947	T22928	aux	do,exhibit
R5676	T22948	T22928	neg	not,exhibit
R5677	T22949	T22950	compound	insulin,resistance
R5678	T22950	T22928	dobj	resistance,exhibit
R5679	T22951	T22922	punct	.,indicate
R5680	T22953	T22954	advmod	Moreover,are
R5681	T22955	T22954	punct	", ",are
R5682	T22956	T22957	det	the,mice
R5683	T22957	T22954	nsubj	mice,are
R5684	T22958	T22959	nmod	PGC,1α
R5685	T22959	T22957	nmod	1α,mice
R5686	T22960	T22959	punct	-,1α
R5687	T22961	T22959	punct	−,1α
R5688	T22962	T22959	punct	/,1α
R5689	T22963	T22959	punct	−,1α
R5690	T22964	T22965	advmod	more,tolerant
R5691	T22965	T22954	acomp	tolerant,are
R5692	T22966	T22965	npadvmod	glucose,tolerant
R5693	T22967	T22965	punct	-,tolerant
R5694	T22968	T22965	cc	and,tolerant
R5695	T22969	T22970	npadvmod	insulin,sensitive
R5696	T22970	T22965	conj	sensitive,tolerant
R5697	T22971	T22970	punct	-,sensitive
R5698	T22972	T22965	prep	than,tolerant
R5699	T22973	T22974	compound	WT,mice
R5700	T22974	T22972	pobj	mice,than
R5701	T22975	T22974	prep	on,mice
R5702	T22976	T22977	det	a,diet
R5703	T22977	T22975	pobj	diet,on
R5704	T22978	T22979	amod	high,fat
R5705	T22979	T22977	compound	fat,diet
R5706	T22980	T22979	punct	-,fat
R5707	T22981	T22954	punct	.,are
R5710	T24084	T24085	amod	Structural,Abnormalities
R5711	T24086	T24085	prep	of,Abnormalities
R5712	T24087	T24088	det	the,System
R5713	T24088	T24086	pobj	System,of
R5714	T24089	T24088	amod	Central,System
R5715	T24090	T24088	amod	Nervous,System
R5716	T24091	T24085	prep	in,Abnormalities
R5717	T24092	T24093	nmod	PGC,1α
R5718	T24093	T24095	nmod	1α,Mice
R5719	T24094	T24093	punct	-,1α
R5720	T24095	T24091	pobj	Mice,in
R5721	T24096	T24093	punct	−,1α
R5722	T24097	T24093	punct	/,1α
R5723	T24098	T24093	punct	−,1α
R5724	T24100	T24101	prep	In,observed
R5725	T24102	T24100	pcomp	surveying,In
R5726	T24103	T24104	det	the,tissues
R5727	T24104	T24102	dobj	tissues,surveying
R5728	T24105	T24104	prep	of,tissues
R5729	T24106	T24107	det	the,mice
R5730	T24107	T24105	pobj	mice,of
R5731	T24108	T24109	nmod	PGC,1α
R5732	T24109	T24107	nmod	1α,mice
R5733	T24110	T24109	punct	-,1α
R5734	T24111	T24109	punct	−,1α
R5735	T24112	T24109	punct	/,1α
R5736	T24113	T24109	punct	−,1α
R5737	T24114	T24101	punct	", ",observed
R5738	T24115	T24116	amod	structural,abnormalities
R5739	T24116	T24101	nsubjpass	abnormalities,observed
R5740	T24117	T24116	prep	of,abnormalities
R5741	T24118	T24119	det	the,brain
R5742	T24119	T24117	pobj	brain,of
R5743	T24120	T24101	auxpass	were,observed
R5744	T24121	T24101	punct	.,observed
R5745	T24123	T24124	npadvmod	Light,microscopic
R5746	T24124	T24125	amod	microscopic,examination
R5747	T24125	T24126	nsubj	examination,demonstrated
R5748	T24127	T24125	prep	of,examination
R5749	T24128	T24129	nmod	PGC,1α
R5750	T24129	T24131	nmod	1α,samples
R5751	T24130	T24129	punct	-,1α
R5752	T24131	T24127	pobj	samples,of
R5753	T24132	T24129	punct	−,1α
R5754	T24133	T24129	punct	/,1α
R5755	T24134	T24129	punct	−,1α
R5756	T24135	T24136	compound	brain,tissue
R5757	T24136	T24131	compound	tissue,samples
R5758	T24137	T24138	det	a,complement
R5759	T24138	T24126	dobj	complement,demonstrated
R5760	T24139	T24140	advmod	well,preserved
R5761	T24140	T24138	amod	preserved,complement
R5762	T24141	T24140	punct	-,preserved
R5763	T24142	T24143	amod	cerebral,cortical
R5764	T24143	T24138	nmod	cortical,complement
R5765	T24144	T24138	amod	neuronal,complement
R5766	T24145	T24126	punct	", ",demonstrated
R5767	T24146	T24147	det	a,result
R5768	T24147	T24126	npadvmod	result,demonstrated
R5769	T24148	T24147	acl	confirmed,result
R5770	T24149	T24148	agent	by,confirmed
R5771	T24150	T24149	pobj	measurement,by
R5772	T24151	T24150	prep	of,measurement
R5773	T24152	T24153	compound	neuron,density
R5774	T24153	T24151	pobj	density,of
R5775	T24154	T24150	prep	in,measurement
R5776	T24155	T24154	pobj	sections,in
R5777	T24156	T24155	prep	of,sections
R5778	T24157	T24158	det	the,lobe
R5779	T24158	T24156	pobj	lobe,of
R5780	T24159	T24158	amod	parietal,lobe
R5781	T24160	T24161	punct	(,significant
R5782	T24161	T24148	parataxis	significant,confirmed
R5783	T24162	T24163	compound	PGC,1α
R5784	T24163	T24165	dep	1α,neurons
R5785	T24164	T24163	punct	-,1α
R5786	T24165	T24161	dep	neurons,significant
R5787	T24166	T24163	punct	+,1α
R5788	T24167	T24163	punct	/,1α
R5789	T24168	T24163	punct	+,1α
R5790	T24169	T24165	punct	", ",neurons
R5791	T24170	T24171	quantmod	"1,261",91
R5792	T24171	T24165	nummod	91,neurons
R5793	T24172	T24171	punct	±,91
R5794	T24173	T24174	punct	/,mm2
R5795	T24174	T24165	prep	mm2,neurons
R5796	T24175	T24165	cc	versus,neurons
R5797	T24176	T24177	compound	PGC,1α
R5798	T24177	T24179	dep	1α,neurons
R5799	T24178	T24177	punct	-,1α
R5800	T24179	T24165	conj	neurons,neurons
R5801	T24180	T24177	punct	−,1α
R5802	T24181	T24177	punct	/,1α
R5803	T24182	T24177	punct	−,1α
R5804	T24183	T24179	punct	", ",neurons
R5805	T24184	T24185	quantmod	"1,299",82
R5806	T24185	T24179	nummod	82,neurons
R5807	T24186	T24185	punct	±,82
R5808	T24187	T24188	punct	/,mm2
R5809	T24188	T24179	prep	mm2,neurons
R5810	T24189	T24161	punct	;,significant
R5811	T24190	T24161	neg	not,significant
R5812	T24191	T24161	punct	),significant
R5813	T24192	T24126	punct	.,demonstrated
R5814	T24194	T24195	amod	Patchy,areas
R5815	T24195	T24196	nsubjpass	areas,noted
R5816	T24197	T24195	prep	of,areas
R5817	T24198	T24197	pobj	microvacuolation,of
R5818	T24199	T24195	acl	involving,areas
R5819	T24200	T24201	det	the,neuropil
R5820	T24201	T24199	dobj	neuropil,involving
R5821	T24202	T24201	cc	and,neuropil
R5822	T24203	T24204	amod	individual,neurons
R5823	T24204	T24201	conj	neurons,neuropil
R5824	T24205	T24204	amod	pyramidal,neurons
R5825	T24206	T24204	prep	of,neurons
R5826	T24207	T24208	det	the,layers
R5827	T24208	T24206	pobj	layers,of
R5828	T24209	T24208	amod	deep,layers
R5829	T24210	T24208	prep	of,layers
R5830	T24211	T24212	det	the,cortex
R5831	T24212	T24210	pobj	cortex,of
R5832	T24213	T24212	amod	cerebral,cortex
R5833	T24214	T24196	auxpass	were,noted
R5834	T24215	T24196	prep	in,noted
R5835	T24216	T24217	det	the,mice
R5836	T24217	T24215	pobj	mice,in
R5837	T24218	T24219	nmod	PGC,1α
R5838	T24219	T24217	nmod	1α,mice
R5839	T24220	T24219	punct	-,1α
R5840	T24221	T24219	punct	−,1α
R5841	T24222	T24219	punct	/,1α
R5842	T24223	T24219	punct	−,1α
R5843	T24224	T24217	cc	but,mice
R5844	T24225	T24224	neg	not,but
R5845	T24226	T24227	det	the,mice
R5846	T24227	T24217	conj	mice,mice
R5847	T24228	T24229	nmod	PGC,1α
R5848	T24229	T24227	nmod	1α,mice
R5849	T24230	T24229	punct	-,1α
R5850	T24231	T24229	punct	+,1α
R5851	T24232	T24229	punct	/,1α
R5852	T24233	T24229	punct	+,1α
R5853	T24234	T24235	punct	(,10A
R5854	T24235	T24196	parataxis	10A,noted
R5855	T24236	T24235	compound	Figure,10A
R5856	T24237	T24235	punct	),10A
R5857	T24238	T24196	punct	.,noted
R5858	T24240	T24241	nsubj	Immunolocalization,failed
R5859	T24242	T24240	prep	of,Immunolocalization
R5860	T24243	T24244	det	an,marker
R5861	T24244	T24242	pobj	marker,of
R5862	T24245	T24244	amod	astrocytic,marker
R5863	T24246	T24244	punct	", ",marker
R5864	T24247	T24248	amod	glial,protein
R5865	T24248	T24244	appos	protein,marker
R5866	T24249	T24248	amod	fibrillary,protein
R5867	T24250	T24248	amod	acidic,protein
R5868	T24251	T24241	punct	", ",failed
R5869	T24252	T24253	aux	to,show
R5870	T24253	T24241	xcomp	show,failed
R5871	T24254	T24255	det	an,increase
R5872	T24255	T24253	dobj	increase,show
R5873	T24256	T24255	prep	in,increase
R5874	T24257	T24256	pobj	numbers,in
R5875	T24258	T24257	prep	of,numbers
R5876	T24259	T24260	amod	astrocytic,processes
R5877	T24260	T24258	pobj	processes,of
R5878	T24261	T24253	prep	in,show
R5879	T24262	T24263	nmod	PGC,1α
R5880	T24263	T24265	nmod	1α,cortex
R5881	T24264	T24263	punct	-,1α
R5882	T24265	T24261	pobj	cortex,in
R5883	T24266	T24263	punct	−,1α
R5884	T24267	T24263	punct	/,1α
R5885	T24268	T24263	punct	−,1α
R5886	T24269	T24265	nmod	mouse,cortex
R5887	T24270	T24265	amod	cerebral,cortex
R5888	T24271	T24272	punct	(,data
R5889	T24272	T24241	meta	data,failed
R5890	T24273	T24272	amod	unpublished,data
R5891	T24274	T24272	punct	),data
R5892	T24275	T24241	punct	.,failed
R5893	T24277	T24278	det	The,hippocampus
R5894	T24278	T24279	nsubj	hippocampus,showed
R5895	T24280	T24279	advmod	also,showed
R5896	T24281	T24282	amod	neuronal,microvacuolation
R5897	T24282	T24279	dobj	microvacuolation,showed
R5898	T24283	T24279	punct	", ",showed
R5899	T24284	T24285	dep	albeit,to
R5900	T24285	T24279	prep	to,showed
R5901	T24286	T24287	det	a,degree
R5902	T24287	T24285	pobj	degree,to
R5903	T24288	T24287	amod	lesser,degree
R5904	T24289	T24287	prep	than,degree
R5905	T24290	T24291	det	the,cortex
R5906	T24291	T24289	pobj	cortex,than
R5907	T24292	T24291	amod	parietal,cortex
R5908	T24293	T24279	punct	.,showed
R5909	T24295	T24296	nsubjpass	Microvacuolation,noted
R5910	T24297	T24295	prep	of,Microvacuolation
R5911	T24298	T24299	det	the,neuropil
R5912	T24299	T24297	pobj	neuropil,of
R5913	T24300	T24299	cc	and,neuropil
R5914	T24301	T24299	conj	neurons,neuropil
R5915	T24302	T24299	prep	of,neuropil
R5916	T24303	T24304	det	the,ganglia
R5917	T24304	T24302	pobj	ganglia,of
R5918	T24305	T24306	nmod	PGC,1α
R5919	T24306	T24304	nmod	1α,ganglia
R5920	T24307	T24306	punct	-,1α
R5921	T24308	T24306	punct	−,1α
R5922	T24309	T24306	punct	/,1α
R5923	T24310	T24306	punct	−,1α
R5924	T24311	T24304	amod	basal,ganglia
R5925	T24312	T24313	punct	(,caudate
R5926	T24313	T24304	parataxis	caudate,ganglia
R5927	T24314	T24313	cc	and,caudate
R5928	T24315	T24313	conj	putamen,caudate
R5929	T24316	T24313	punct	),caudate
R5930	T24317	T24296	auxpass	was,noted
R5931	T24318	T24296	advmod	also,noted
R5932	T24319	T24296	prep	in,noted
R5933	T24320	T24319	pobj	association,in
R5934	T24321	T24320	prep	with,association
R5935	T24322	T24323	det	a,increase
R5936	T24323	T24321	pobj	increase,with
R5937	T24324	T24323	amod	patchy,increase
R5938	T24325	T24323	prep	in,increase
R5939	T24326	T24327	det	the,number
R5940	T24327	T24325	pobj	number,in
R5941	T24328	T24327	cc	and,number
R5942	T24329	T24327	conj	intensity,number
R5943	T24330	T24327	prep	of,number
R5944	T24331	T24332	amod	glial,protein
R5945	T24332	T24335	npadvmod	protein,immunoreactive
R5946	T24333	T24332	amod	fibrillary,protein
R5947	T24334	T24332	amod	acidic,protein
R5948	T24335	T24337	amod	immunoreactive,processes
R5949	T24336	T24335	punct	-,immunoreactive
R5950	T24337	T24330	pobj	processes,of
R5951	T24338	T24337	amod	astrocytic,processes
R5952	T24339	T24340	punct	(,data
R5953	T24340	T24296	meta	data,noted
R5954	T24341	T24340	amod	unpublished,data
R5955	T24342	T24340	punct	),data
R5956	T24343	T24296	punct	.,noted
R5957	T24345	T24346	nsubj	Areas,involved
R5958	T24347	T24345	prep	of,Areas
R5959	T24348	T24347	pobj	microvacuolation,of
R5960	T24349	T24346	advmod	also,involved
R5961	T24350	T24351	amod	multiple,regions
R5962	T24351	T24346	dobj	regions,involved
R5963	T24352	T24351	compound	brainstem,regions
R5964	T24353	T24346	punct	.,involved
R5965	T24355	T24356	advmod	Only,neurons
R5966	T24356	T24363	nsubjpass	neurons,identified
R5967	T24357	T24356	amod	rare,neurons
R5968	T24358	T24356	amod	vacuolated,neurons
R5969	T24359	T24356	nmod	Purkinje,neurons
R5970	T24360	T24359	cc	and,Purkinje
R5971	T24361	T24362	compound	granule,cell
R5972	T24362	T24359	conj	cell,Purkinje
R5973	T24364	T24363	auxpass	were,identified
R5974	T24365	T24363	prep	in,identified
R5975	T24366	T24367	det	the,cortex
R5976	T24367	T24365	pobj	cortex,in
R5977	T24368	T24369	nmod	PGC,1α
R5978	T24369	T24367	nmod	1α,cortex
R5979	T24370	T24369	punct	-,1α
R5980	T24371	T24369	punct	−,1α
R5981	T24372	T24369	punct	/,1α
R5982	T24373	T24369	punct	−,1α
R5983	T24374	T24367	amod	cerebellar,cortex
R5984	T24375	T24363	punct	.,identified
R5985	T24377	T24378	preconj	Neither,proliferation
R5986	T24378	T24380	nsubjpass	proliferation,noted
R5987	T24379	T24378	amod	microglial,proliferation
R5988	T24381	T24378	cc	nor,proliferation
R5989	T24382	T24383	amod	perivascular,infiltrates
R5990	T24383	T24378	conj	infiltrates,proliferation
R5991	T24384	T24383	amod	lymphocytic,infiltrates
R5992	T24385	T24383	amod	inflammatory,infiltrates
R5993	T24386	T24380	auxpass	were,noted
R5994	T24387	T24380	prep	in,noted
R5995	T24388	T24389	det	the,CNS
R5996	T24389	T24387	pobj	CNS,in
R5997	T24390	T24391	nmod	PGC,1α
R5998	T24391	T24389	nmod	1α,CNS
R5999	T24392	T24391	punct	-,1α
R6000	T24393	T24391	punct	−,1α
R6001	T24394	T24391	punct	/,1α
R6002	T24395	T24391	punct	−,1α
R6003	T24396	T24380	punct	.,noted
R6004	T24398	T24399	amod	Ultrastructural,examination
R6005	T24399	T24400	nsubj	examination,confirmed
R6006	T24401	T24399	prep	of,examination
R6007	T24402	T24403	det	the,cortex
R6008	T24403	T24401	pobj	cortex,of
R6009	T24404	T24405	nmod	PGC,1α
R6010	T24405	T24403	nmod	1α,cortex
R6011	T24406	T24405	punct	-,1α
R6012	T24407	T24405	punct	−,1α
R6013	T24408	T24405	punct	/,1α
R6014	T24409	T24405	punct	−,1α
R6015	T24410	T24403	amod	parietal,cortex
R6016	T24411	T24403	amod	cerebral,cortex
R6017	T24412	T24413	det	the,presence
R6018	T24413	T24400	dobj	presence,confirmed
R6019	T24414	T24413	prep	of,presence
R6020	T24415	T24416	amod	microvacuolated,neurons
R6021	T24416	T24414	pobj	neurons,of
R6022	T24417	T24416	cc	and,neurons
R6023	T24418	T24416	conj	neuropil,neurons
R6024	T24419	T24420	punct	(,10B
R6025	T24420	T24400	parataxis	10B,confirmed
R6026	T24421	T24420	compound	Figure,10B
R6027	T24422	T24420	punct	),10B
R6028	T24423	T24400	punct	.,confirmed
R6029	T24425	T24426	nsubj	Vacuoles,were
R6030	T24427	T24425	acl	containing,Vacuoles
R6031	T24428	T24427	dobj	aggregates,containing
R6032	T24429	T24428	prep	of,aggregates
R6033	T24430	T24431	amod	membranous,material
R6034	T24431	T24429	pobj	material,of
R6035	T24432	T24426	acomp	present,were
R6036	T24433	T24426	prep	in,were
R6037	T24434	T24435	det	a,subset
R6038	T24435	T24433	pobj	subset,in
R6039	T24436	T24435	prep	of,subset
R6040	T24437	T24438	amod	cortical,neurons
R6041	T24438	T24436	pobj	neurons,of
R6042	T24439	T24426	punct	.,were
R6043	T24441	T24442	amod	Subcellular,localization
R6044	T24442	T24443	nsubj	localization,was
R6045	T24443	T24447	ccomp	was,represent
R6046	T24444	T24442	prep	of,localization
R6047	T24445	T24446	det	the,vacuoles
R6048	T24446	T24444	pobj	vacuoles,of
R6049	T24448	T24443	acomp	difficult,was
R6050	T24449	T24450	aux	to,establish
R6051	T24450	T24448	advcl	establish,difficult
R6052	T24451	T24447	punct	;,represent
R6053	T24452	T24447	nsubj	some,represent
R6054	T24453	T24447	aux	may,represent
R6055	T24454	T24455	amod	vacuolated,elements
R6056	T24455	T24447	dobj	elements,represent
R6057	T24456	T24455	prep	of,elements
R6058	T24457	T24458	det	the,neuropil
R6059	T24458	T24456	pobj	neuropil,of
R6060	T24459	T24455	punct	", ",elements
R6061	T24460	T24455	conj	material,elements
R6062	T24461	T24460	prep	in,material
R6063	T24462	T24463	amod	phagocytic,cells
R6064	T24463	T24461	pobj	cells,in
R6065	T24464	T24460	punct	", ",material
R6066	T24465	T24466	amod	presynaptic,terminals
R6067	T24466	T24460	conj	terminals,material
R6068	T24467	T24466	compound	nerve,terminals
R6069	T24468	T24466	acl	compressing,terminals
R6070	T24469	T24470	det	the,soma
R6071	T24470	T24468	dobj	soma,compressing
R6072	T24471	T24466	punct	", ",terminals
R6073	T24472	T24466	cc	or,terminals
R6074	T24473	T24474	amod	genuine,deposits
R6075	T24474	T24466	conj	deposits,terminals
R6076	T24475	T24474	amod	intraperikaryal,deposits
R6077	T24476	T24447	punct	.,represent
R6094	T30486	T30485	punct	],6
R6095	T30442	T30443	amod	Previous,studies
R6096	T30443	T30444	nsubj	studies,shown
R6097	T30445	T30443	acl	using,studies
R6098	T30446	T30447	nmod	gain,strategies
R6099	T30447	T30445	dobj	strategies,using
R6100	T30448	T30446	punct	-,gain
R6101	T30449	T30446	prep	of,gain
R6102	T30450	T30449	punct	-,of
R6103	T30451	T30449	pobj	function,of
R6104	T30452	T30444	aux	have,shown
R6105	T30453	T30454	mark	that,is
R6106	T30454	T30444	ccomp	is,shown
R6107	T30455	T30456	det	the,coactivator
R6108	T30456	T30454	nsubj	coactivator,is
R6109	T30457	T30458	compound	PGC,1α
R6110	T30458	T30456	appos	1α,coactivator
R6111	T30459	T30458	punct	-,1α
R6112	T30460	T30454	acomp	capable,is
R6113	T30461	T30460	prep	of,capable
R6114	T30462	T30461	pcomp	coactivating,of
R6115	T30487	T30444	punct	.,shown
R6116	T30463	T30464	det	an,array
R6117	T30489	T30490	amod	Forced,expression
R6118	T30464	T30462	dobj	array,coactivating
R6119	T30465	T30464	prep	of,array
R6120	T30466	T30467	compound	transcription,factors
R6121	T30467	T30465	pobj	factors,of
R6122	T30468	T30467	acl	involved,factors
R6123	T30469	T30468	prep	in,involved
R6124	T30490	T30491	nsubj	expression,triggers
R6125	T30470	T30471	nmod	energy,processes
R6126	T30471	T30469	pobj	processes,in
R6127	T30472	T30471	amod	metabolic,processes
R6128	T30473	T30471	prep	including,processes
R6129	T30474	T30475	amod	fatty,acid
R6130	T30475	T30476	compound	acid,oxidation
R6131	T30476	T30473	pobj	oxidation,including
R6132	T30477	T30476	punct	", ",oxidation
R6133	T30478	T30479	compound	electron,transport
R6134	T30479	T30476	conj	transport,oxidation
R6135	T30480	T30479	punct	", ",transport
R6136	T30492	T30490	prep	of,expression
R6137	T30481	T30479	cc	and,transport
R6138	T30482	T30483	amod	oxidative,phosphorylation
R6139	T30483	T30479	conj	phosphorylation,transport
R6140	T30484	T30485	punct	[,6
R6141	T30493	T30494	compound	PGC,1α
R6142	T30485	T30444	parataxis	6,shown
R6143	T30494	T30492	pobj	1α,of
R6144	T30495	T30494	punct	-,1α
R6145	T30496	T30497	amod	mitochondrial,biogenesis
R6146	T30497	T30491	dobj	biogenesis,triggers
R6147	T30498	T30491	prep	by,triggers
R6148	T30499	T30498	pcomp	activating,by
R6149	T30592	T30591	punct	", ",support
R6150	T30500	T30501	det	a,circuitry
R6151	T30593	T30594	amod	several,lines
R6152	T30594	T30591	nsubj	lines,support
R6153	T30595	T30594	prep	of,lines
R6154	T30501	T30499	dobj	circuitry,activating
R6155	T30596	T30595	pobj	evidence,of
R6156	T30597	T30598	det	the,conclusion
R6157	T30502	T30501	amod	complex,circuitry
R6158	T30598	T30591	dobj	conclusion,support
R6159	T30599	T30600	mark	that,is
R6160	T30600	T30598	acl	is,conclusion
R6161	T30503	T30501	prep	of,circuitry
R6162	T30601	T30602	compound	PGC,1α
R6163	T30602	T30600	nsubj	1α,is
R6164	T30504	T30503	pobj	factors,of
R6165	T30603	T30602	punct	-,1α
R6166	T30604	T30600	acomp	necessary,is
R6167	T30605	T30604	prep	for,necessary
R6168	T30505	T30504	prep	including,factors
R6169	T30606	T30607	det	the,programs
R6170	T30607	T30605	pobj	programs,for
R6171	T30608	T30609	dep	that,regulate
R6172	T30506	T30505	pobj	NRF,including
R6173	T30609	T30607	relcl	regulate,programs
R6174	T30507	T30506	punct	-,NRF
R6175	T30610	T30611	amod	postnatal,function
R6176	T30611	T30609	dobj	function,regulate
R6177	T30612	T30611	amod	mitochondrial,function
R6178	T30613	T30611	cc	and,function
R6179	T30508	T30506	nummod	1,NRF
R6180	T30614	T30615	amod	cellular,metabolism
R6181	T30615	T30611	conj	metabolism,function
R6182	T30616	T30615	compound	energy,metabolism
R6183	T30617	T30611	punct	", ",function
R6184	T30618	T30611	appos	processes,function
R6185	T30619	T30620	dep	that,equip
R6186	T30509	T30506	punct	", ",NRF
R6187	T30620	T30618	relcl	equip,processes
R6188	T30621	T30622	det	the,organism
R6189	T30622	T30620	dobj	organism,equip
R6190	T30510	T30506	conj	NRF,NRF
R6191	T30623	T30620	prep	for,equip
R6192	T30624	T30625	det	the,rigors
R6193	T30625	T30623	pobj	rigors,for
R6194	T30511	T30510	punct	-,NRF
R6195	T30626	T30627	npadvmod	energy,metabolic
R6196	T30627	T30625	amod	metabolic,rigors
R6197	T30512	T30510	nummod	2,NRF
R6198	T30628	T30625	prep	of,rigors
R6199	T30629	T30630	det	the,environment
R6200	T30630	T30628	pobj	environment,of
R6201	T30513	T30510	punct	", ",NRF
R6202	T30631	T30630	amod	postnatal,environment
R6203	T30632	T30591	punct	.,support
R6204	T30514	T30510	cc	and,NRF
R6205	T30634	T30635	advmod	First,diminished
R6206	T30515	T30516	det	the,receptor
R6207	T30636	T30635	punct	", ",diminished
R6208	T30637	T30638	amod	mitochondrial,density
R6209	T30638	T30635	nsubjpass	density,diminished
R6210	T30516	T30510	conj	receptor,NRF
R6211	T30639	T30638	compound	volume,density
R6212	T30640	T30635	auxpass	is,diminished
R6213	T30641	T30635	prep	in,diminished
R6214	T30517	T30516	nmod	orphan,receptor
R6215	T30642	T30643	amod	slow,twitch
R6216	T30643	T30645	nmod	twitch,muscle
R6217	T30518	T30516	amod	nuclear,receptor
R6218	T30644	T30643	punct	-,twitch
R6219	T30645	T30641	pobj	muscle,in
R6220	T30646	T30645	amod	skeletal,muscle
R6221	T30519	T30520	npadvmod	estrogen,related
R6222	T30647	T30645	prep	of,muscle
R6223	T30648	T30649	nmod	PGC,1α
R6224	T30649	T30651	nmod	1α,mice
R6225	T30520	T30522	amod	related,α
R6226	T30650	T30649	punct	-,1α
R6227	T30651	T30647	pobj	mice,of
R6228	T30521	T30520	punct	-,related
R6229	T30652	T30649	punct	−,1α
R6230	T30653	T30649	punct	/,1α
R6231	T30654	T30649	punct	−,1α
R6232	T30655	T30635	punct	.,diminished
R6233	T30522	T30516	appos	α,receptor
R6234	T30657	T30658	advmod	Second,altered
R6235	T30659	T30658	punct	", ",altered
R6236	T30523	T30522	compound	receptor,α
R6237	T30660	T30661	amod	mitochondrial,capacity
R6238	T30661	T30658	nsubjpass	capacity,altered
R6239	T30662	T30661	amod	respiratory,capacity
R6240	T30524	T30525	punct	[,32
R6241	T30663	T30658	auxpass	is,altered
R6242	T30664	T30658	advmod	modestly,altered
R6243	T30665	T30664	cc	but,modestly
R6244	T30525	T30491	parataxis	32,triggers
R6245	T30666	T30664	conj	significantly,modestly
R6246	T30667	T30658	prep	in,altered
R6247	T30668	T30669	amod	skeletal,muscle
R6248	T30526	T30525	nummod	23,32
R6249	T30669	T30667	pobj	muscle,in
R6250	T30670	T30669	cc	and,muscle
R6251	T30527	T30525	punct	",",32
R6253	T30528	T30525	punct	],32
R6254	T30672	T30669	prep	of,muscle
R6255	T30673	T30674	nmod	PGC,1α
R6256	T30529	T30491	punct	.,triggers
R6257	T30674	T30676	nmod	1α,mice
R6258	T30675	T30674	punct	-,1α
R6259	T30676	T30672	pobj	mice,of
R6260	T30531	T30532	advmod	However,determine
R6261	T30677	T30674	punct	−,1α
R6262	T30678	T30674	punct	/,1α
R6263	T30679	T30674	punct	−,1α
R6264	T30680	T30658	punct	.,altered
R6265	T30533	T30532	punct	", ",determine
R6266	T30682	T30683	advmod	Third,blunted
R6267	T30534	T30535	nmod	gain,strategies
R6268	T30684	T30683	punct	", ",blunted
R6269	T30685	T30686	det	the,growth
R6270	T30686	T30683	nsubjpass	growth,blunted
R6271	T30535	T30532	nsubj	strategies,determine
R6272	T30687	T30686	prep	of,growth
R6273	T30688	T30687	pobj	heart,of
R6274	T30536	T30534	punct	-,gain
R6275	T30689	T30688	cc	and,heart
R6276	T30690	T30691	compound	soleus,muscle
R6277	T30691	T30688	conj	muscle,heart
R6278	T30692	T30688	punct	", ",heart
R6279	T30537	T30534	prep	of,gain
R6280	T30693	T30688	appos	tissues,heart
R6281	T30538	T30537	punct	-,of
R6282	T30694	T30693	prep	with,tissues
R6283	T30695	T30696	amod	high,reliance
R6284	T30696	T30694	pobj	reliance,with
R6285	T30539	T30537	pobj	function,of
R6286	T30540	T30532	aux	can,determine
R6287	T30697	T30696	prep	on,reliance
R6288	T30698	T30699	amod	mitochondrial,production
R6289	T30699	T30697	pobj	production,on
R6290	T30541	T30532	neg	not,determine
R6291	T30700	T30699	compound	energy,production
R6292	T30701	T30683	punct	", ",blunted
R6293	T30542	T30543	mark	whether,is
R6294	T30702	T30683	auxpass	is,blunted
R6295	T30703	T30683	punct	.,blunted
R6296	T30543	T30532	ccomp	is,determine
R6297	T30705	T30706	advmod	Fourth,is
R6298	T30707	T30706	punct	", ",is
R6299	T30544	T30545	compound	PGC,1α
R6300	T30708	T30706	nsubj	control,is
R6301	T30709	T30708	prep	of,control
R6302	T30710	T30711	compound	body,fat
R6303	T30711	T30712	compound	fat,mass
R6304	T30545	T30543	nsubj	1α,is
R6305	T30712	T30709	pobj	mass,of
R6306	T30713	T30706	acomp	abnormal,is
R6307	T30546	T30545	punct	-,1α
R6308	T30714	T30706	prep	in,is
R6309	T30715	T30716	det	the,mice
R6310	T30716	T30714	pobj	mice,in
R6311	T30547	T30543	acomp	essential,is
R6312	T30717	T30718	nmod	PGC,1α
R6313	T30718	T30716	nmod	1α,mice
R6314	T30719	T30718	punct	-,1α
R6315	T30548	T30547	prep	for,essential
R6316	T30720	T30718	punct	−,1α
R6317	T30721	T30718	punct	/,1α
R6318	T30549	T30550	amod	critical,processes
R6319	T30722	T30718	punct	−,1α
R6320	T30723	T30706	punct	.,is
R6321	T30550	T30548	pobj	processes,for
R6322	T30725	T30726	advmod	Finally,respond
R6323	T30551	T30552	npadvmod	energy,metabolic
R6324	T30727	T30726	punct	", ",respond
R6325	T30728	T30729	nmod	PGC,1α
R6326	T30729	T30731	nmod	1α,mice
R6327	T30552	T30550	amod	metabolic,processes
R6328	T30730	T30729	punct	-,1α
R6329	T30731	T30726	nsubj	mice,respond
R6330	T30732	T30729	punct	−,1α
R6331	T30553	T30550	prep	including,processes
R6332	T30733	T30729	punct	/,1α
R6333	T30734	T30729	punct	−,1α
R6334	T30554	T30555	amod	mitochondrial,biogenesis
R6335	T30735	T30726	aux	do,respond
R6336	T30736	T30726	neg	not,respond
R6337	T30737	T30726	advmod	normally,respond
R6338	T30738	T30726	prep	to,respond
R6339	T30739	T30740	det	a,variety
R6340	T30555	T30553	pobj	biogenesis,including
R6341	T30740	T30738	pobj	variety,to
R6342	T30741	T30740	prep	of,variety
R6343	T30742	T30743	amod	physiologic,stresses
R6344	T30556	T30555	cc	and,biogenesis
R6345	T30743	T30741	pobj	stresses,of
R6346	T30744	T30742	cc	and,physiologic
R6347	T30745	T30742	conj	dietary,physiologic
R6348	T30557	T30555	conj	function,biogenesis
R6349	T30746	T30743	acl	known,stresses
R6350	T30747	T30748	aux	to,increase
R6351	T30558	T30532	punct	.,determine
R6352	T30748	T30746	xcomp	increase,known
R6353	T30749	T30750	amod	oxidative,demands
R6354	T30750	T30748	dobj	demands,increase
R6355	T30560	T30561	advcl	Using,show
R6356	T30751	T30750	compound	energy,demands
R6357	T30752	T30726	punct	.,respond
R6358	T30754	T30755	advcl	Taken,suggest
R6359	T30562	T30563	amod	targeted,deletion
R6360	T30756	T30754	advmod	together,Taken
R6361	T30757	T30755	punct	", ",suggest
R6362	T30758	T30759	det	these,results
R6363	T30563	T30560	dobj	deletion,Using
R6364	T30759	T30755	nsubj	results,suggest
R6365	T30760	T30755	advmod	strongly,suggest
R6366	T30564	T30563	compound	gene,deletion
R6367	T30565	T30560	prep	in,Using
R6368	T30761	T30762	mark	that,is
R6369	T30762	T30755	ccomp	is,suggest
R6370	T30566	T30565	pobj	mice,in
R6371	T30763	T30764	compound	PGC,1α
R6372	T30764	T30762	nsubj	1α,is
R6373	T30765	T30764	punct	-,1α
R6374	T30567	T30561	punct	", ",show
R6375	T30766	T30762	acomp	necessary,is
R6376	T30767	T30766	prep	for,necessary
R6377	T30768	T30769	det	the,stages
R6378	T30568	T30561	nsubj	we,show
R6379	T30769	T30767	pobj	stages,for
R6380	T30569	T30561	advmod	here,show
R6381	T30770	T30769	amod	terminal,stages
R6382	T30771	T30769	prep	of,stages
R6383	T30772	T30773	amod	mitochondrial,maturation
R6384	T30570	T30571	mark	that,is
R6385	T30773	T30771	pobj	maturation,of
R6386	T30774	T30769	amod	necessary,stages
R6387	T30775	T30776	aux	to,meet
R6388	T30571	T30561	ccomp	is,show
R6389	T30776	T30774	xcomp	meet,necessary
R6390	T30572	T30573	compound	PGC,1α
R6391	T30777	T30778	det	the,demands
R6392	T30778	T30776	dobj	demands,meet
R6393	T30573	T30571	nsubj	1α,is
R6394	T30779	T30778	compound	energy,demands
R6395	T30780	T30778	prep	of,demands
R6396	T30574	T30573	punct	-,1α
R6397	T30781	T30782	det	the,environment
R6398	T30782	T30780	pobj	environment,of
R6399	T30575	T30571	neg	not,is
R6400	T30783	T30782	amod	postnatal,environment
R6401	T30784	T30755	punct	.,suggest
R6402	T30576	T30571	acomp	essential,is
R6403	T30786	T30787	amod	Extensive,analyses
R6404	T30787	T30789	nsubj	analyses,demonstrated
R6405	T30577	T30576	prep	for,essential
R6406	T30788	T30787	amod	phenotypic,analyses
R6407	T30790	T30791	mark	that,are
R6408	T30578	T30579	amod	normal,development
R6409	T30791	T30789	ccomp	are,demonstrated
R6410	T30792	T30791	nsubj	mice,are
R6411	T30793	T30792	acl	lacking,mice
R6412	T30579	T30577	pobj	development,for
R6413	T30794	T30795	compound	PGC,1α
R6414	T30795	T30793	dobj	1α,lacking
R6415	T30796	T30795	punct	-,1α
R6416	T30580	T30579	amod	embryologic,development
R6417	T30797	T30791	acomp	unable,are
R6418	T30798	T30799	aux	to,cope
R6419	T30581	T30579	cc	or,development
R6420	T30799	T30797	xcomp	cope,unable
R6421	T30800	T30799	prep	with,cope
R6422	T30801	T30802	amod	physiologic,stressors
R6423	T30582	T30583	det	the,events
R6424	T30802	T30800	pobj	stressors,with
R6425	T30583	T30579	conj	events,development
R6426	T30584	T30583	amod	fundamental,events
R6427	T30585	T30583	prep	of,events
R6428	T30803	T30802	amod	relevant,stressors
R6429	T30804	T30803	prep	to,relevant
R6430	T30586	T30587	amod	mitochondrial,biogenesis
R6431	T30805	T30806	amod	postnatal,survival
R6432	T30806	T30804	pobj	survival,to
R6433	T30807	T30789	punct	.,demonstrated
R6434	T30587	T30585	pobj	biogenesis,of
R6435	T30809	T30810	prep	For,unveiled
R6436	T30588	T30561	punct	.,show
R6437	T30811	T30809	pobj	example,For
R6438	T30812	T30810	punct	", ",unveiled
R6439	T30813	T30814	det	a,phenotype
R6440	T30814	T30810	nsubjpass	phenotype,unveiled
R6441	T30590	T30591	advmod	However,support
R6442	T30815	T30816	amod	skeletal,muscle
R6443	T30816	T30814	compound	muscle,phenotype
R6444	T30817	T30810	auxpass	was,unveiled
R6445	T30818	T30810	prep	in,unveiled
R6446	T30819	T30820	nmod	PGC,1α
R6447	T30909	T30908	compound	heart,rate
R6448	T30820	T30822	nmod	1α,mice
R6449	T30821	T30820	punct	-,1α
R6450	T30822	T30818	pobj	mice,in
R6451	T30823	T30820	punct	−,1α
R6452	T30910	T30904	punct	", ",abnormalities
R6453	T30824	T30820	punct	/,1α
R6454	T30825	T30820	punct	−,1α
R6455	T30911	T30904	prep	including,abnormalities
R6456	T30826	T30810	prep	under,unveiled
R6457	T30827	T30826	pobj	conditions,under
R6458	T30828	T30829	prep	in,becomes
R6459	T30912	T30913	det	a,response
R6460	T30829	T30827	relcl	becomes,conditions
R6461	T30830	T30828	pobj	which,in
R6462	T30831	T30832	compound	energy,supply
R6463	T30913	T30911	pobj	response,including
R6464	T30832	T30829	nsubj	supply,becomes
R6465	T30833	T30829	acomp	limiting,becomes
R6466	T30914	T30913	amod	blunted,response
R6467	T30834	T30810	punct	.,unveiled
R6468	T30836	T30837	nsubjpass	This,demonstrated
R6469	T30915	T30913	prep	to,response
R6470	T30838	T30837	auxpass	was,demonstrated
R6471	T30916	T30917	npadvmod	β,adrenergic
R6472	T30839	T30840	advmod	most,clearly
R6473	T30840	T30837	advmod	clearly,demonstrated
R6474	T30841	T30837	agent	by,demonstrated
R6475	T30917	T30919	amod	adrenergic,stimulation
R6476	T30842	T30843	det	the,abnormalities
R6477	T30843	T30841	pobj	abnormalities,by
R6478	T30844	T30843	amod	profound,abnormalities
R6479	T30918	T30917	punct	-,adrenergic
R6480	T30845	T30843	acl	exhibited,abnormalities
R6481	T30846	T30845	agent	by,exhibited
R6482	T30847	T30848	nmod	PGC,1α
R6483	T30919	T30915	pobj	stimulation,to
R6484	T30920	T30901	punct	", ",is
R6485	T30921	T30901	acomp	unknown,is
R6486	T30848	T30850	nmod	1α,mice
R6487	T30849	T30848	punct	-,1α
R6488	T30922	T30901	punct	", ",is
R6489	T30850	T30846	pobj	mice,by
R6490	T30851	T30848	punct	−,1α
R6491	T30852	T30848	punct	/,1α
R6492	T30853	T30848	punct	−,1α
R6493	T30854	T30845	prep	with,exhibited
R6494	T30923	T30901	cc	but,is
R6495	T30855	T30856	nmod	exercise,studies
R6496	T30856	T30854	pobj	studies,with
R6497	T30924	T30925	aux	could,be
R6498	T30857	T30855	punct	-,exercise
R6499	T30858	T30855	prep	to,exercise
R6500	T30859	T30858	punct	-,to
R6501	T30860	T30858	pobj	exhaustion,to
R6502	T30925	T30901	conj	be,is
R6503	T30861	T30855	cc	and,exercise
R6504	T30862	T30863	amod	repetitive,stimulation
R6505	T30926	T30925	acomp	related,be
R6506	T30863	T30855	conj	stimulation,exercise
R6507	T30864	T30863	compound	muscle,stimulation
R6508	T30865	T30837	punct	.,demonstrated
R6509	T30927	T30926	prep	to,related
R6510	T30867	T30868	advmod	Similarly,compromised
R6511	T30928	T30929	det	the,effects
R6512	T30869	T30868	punct	", ",compromised
R6513	T30870	T30871	amod	cardiac,performance
R6514	T30929	T30927	pobj	effects,to
R6515	T30871	T30868	nsubjpass	performance,compromised
R6516	T30872	T30871	prep	of,performance
R6517	T30930	T30929	prep	of,effects
R6518	T30873	T30874	nmod	PGC,1α
R6519	T30874	T30876	nmod	1α,mice
R6520	T30875	T30874	punct	-,1α
R6521	T30931	T30932	amod	late,stage
R6522	T30876	T30872	pobj	mice,of
R6523	T30877	T30874	punct	−,1α
R6524	T30878	T30874	punct	/,1α
R6525	T30932	T30934	compound	stage,arrest
R6526	T30879	T30874	punct	−,1α
R6527	T30880	T30868	auxpass	was,compromised
R6528	T30881	T30868	prep	following,compromised
R6529	T30933	T30932	punct	-,stage
R6530	T30882	T30883	amod	severe,exertion
R6531	T30883	T30881	pobj	exertion,following
R6532	T30884	T30868	punct	.,compromised
R6533	T30934	T30930	pobj	arrest,of
R6534	T30886	T30887	det	This,effect
R6535	T30887	T30888	nsubj	effect,was
R6536	T30935	T30934	compound	growth,arrest
R6537	T30889	T30888	advmod	largely,was
R6538	T30890	T30888	prep	due,was
R6539	T30936	T30929	cc	and,effects
R6540	T30891	T30890	pcomp	to,due
R6541	T30892	T30893	det	an,response
R6542	T30937	T30938	amod	corresponding,derangements
R6543	T30893	T30890	pobj	response,due
R6544	T30894	T30893	amod	abnormal,response
R6545	T30895	T30896	compound	heart,rate
R6546	T30896	T30893	compound	rate,response
R6547	T30897	T30888	punct	.,was
R6548	T30938	T30929	conj	derangements,effects
R6549	T30899	T30900	det	The,basis
R6550	T30900	T30901	nsubj	basis,is
R6551	T30939	T30938	prep	in,derangements
R6552	T30902	T30900	prep	for,basis
R6553	T30903	T30904	det	the,abnormalities
R6554	T30904	T30902	pobj	abnormalities,for
R6555	T30940	T30941	compound	energy,metabolism
R6556	T30905	T30904	amod	observed,abnormalities
R6557	T30906	T30904	prep	of,abnormalities
R6558	T30941	T30939	pobj	metabolism,in
R6559	T30907	T30908	amod	cardiac,rate
R6560	T30908	T30906	pobj	rate,of
R6561	T30942	T30938	prep	on,derangements
R6562	T30943	T30944	compound	sinus,node
R6563	T30944	T30945	compound	node,function
R6564	T30945	T30942	pobj	function,on
R6565	T31015	T31016	nsubj	Studies,confirmed
R6566	T31017	T31015	prep	with,Studies
R6567	T30946	T30901	punct	.,is
R6568	T31018	T31019	det	a,agonist
R6569	T30948	T30949	compound	PGC,1α
R6570	T31019	T31017	pobj	agonist,with
R6571	T30949	T30951	nsubjpass	1α,identified
R6572	T31020	T31021	npadvmod	β3,adrenergic
R6573	T31021	T31019	amod	adrenergic,agonist
R6574	T31022	T31021	punct	-,adrenergic
R6575	T30950	T30949	punct	-,1α
R6576	T31023	T31024	mark	that,diminished
R6577	T31024	T31016	ccomp	diminished,confirmed
R6578	T31025	T31026	det	the,rate
R6579	T30952	T30951	auxpass	was,identified
R6580	T31026	T31024	nsubjpass	rate,diminished
R6581	T31027	T31026	amod	peak,rate
R6582	T31028	T31029	compound	oxygen,consumption
R6583	T31029	T31026	compound	consumption,rate
R6584	T30953	T30951	advmod	first,identified
R6585	T31030	T31026	prep	in,rate
R6586	T31031	T31032	amod	thermogenic,tissue
R6587	T30954	T30951	prep	as,identified
R6588	T31032	T31030	pobj	tissue,in
R6589	T31033	T31024	auxpass	is,diminished
R6590	T31034	T31024	prep	in,diminished
R6591	T30955	T30956	det	a,coactivator
R6592	T31035	T31036	nmod	PGC,1α
R6593	T31036	T31038	nmod	1α,mice
R6594	T31037	T31036	punct	-,1α
R6595	T31038	T31034	pobj	mice,in
R6596	T31039	T31036	punct	−,1α
R6597	T31040	T31036	punct	/,1α
R6598	T30956	T30954	pobj	coactivator,as
R6599	T31041	T31036	punct	−,1α
R6600	T31042	T31016	punct	.,confirmed
R6601	T30957	T30951	prep	in,identified
R6602	T31044	T31045	nsubj	We,propose
R6603	T31046	T31047	mark	that,related
R6604	T30958	T30957	pobj	BAT,in
R6605	T31047	T31045	ccomp	related,propose
R6606	T31048	T31049	det	the,phenotype
R6607	T30959	T30960	punct	[,2
R6608	T31049	T31047	nsubjpass	phenotype,related
R6609	T31050	T31049	amod	thermogenic,phenotype
R6610	T31051	T31047	auxpass	is,related
R6611	T30960	T30951	parataxis	2,identified
R6612	T31052	T31047	prep	to,related
R6613	T31053	T31054	amod	reduced,capacity
R6614	T31054	T31052	pobj	capacity,to
R6615	T30961	T30960	punct	],2
R6616	T31055	T31054	prep	for,capacity
R6617	T31056	T31057	amod	mitochondrial,respiration
R6618	T30962	T30951	punct	.,identified
R6619	T31057	T31055	pobj	respiration,for
R6620	T31058	T31054	prep	in,capacity
R6621	T30964	T30965	advmod	Indeed,found
R6622	T31059	T31058	pobj	BAT,in
R6623	T31060	T31045	punct	.,propose
R6624	T31062	T31063	advmod	Interestingly,was
R6625	T30966	T30965	punct	", ",found
R6626	T31064	T31063	punct	", ",was
R6627	T31065	T31066	det	this,phenotype
R6628	T31066	T31063	nsubj	phenotype,was
R6629	T31067	T31063	advmod	only,was
R6630	T30967	T30965	nsubj	we,found
R6631	T31068	T31063	acomp	evident,was
R6632	T31069	T31063	prep	during,was
R6633	T31070	T31071	det	a,window
R6634	T30968	T30969	mark	that,resulted
R6635	T31071	T31069	pobj	window,during
R6636	T31072	T31073	advmod	rather,narrow
R6637	T31073	T31071	amod	narrow,window
R6638	T30969	T30965	ccomp	resulted,found
R6639	T31074	T31071	prep	of,window
R6640	T31075	T31076	amod	postnatal,life
R6641	T30970	T30969	nsubj	exposure,resulted
R6642	T31076	T31074	pobj	life,of
R6643	T31077	T31063	punct	.,was
R6644	T30971	T30970	prep	of,exposure
R6645	T31079	T31080	nsubj	Animals,exhibit
R6646	T30972	T30973	det	the,mice
R6647	T31081	T31079	prep	at,Animals
R6648	T31082	T31083	det	an,age
R6649	T31083	T31081	pobj	age,at
R6650	T31084	T31083	amod	older,age
R6651	T31085	T31080	aux	did,exhibit
R6652	T31086	T31080	neg	not,exhibit
R6653	T30973	T30971	pobj	mice,of
R6654	T31087	T31088	compound	cold,intolerance
R6655	T31088	T31080	dobj	intolerance,exhibit
R6656	T31089	T31080	punct	", ",exhibit
R6657	T30974	T30975	nmod	PGC,1α
R6658	T31090	T31091	advmod	possibly,due
R6659	T31091	T31080	prep	due,exhibit
R6660	T31092	T31091	pcomp	to,due
R6661	T30975	T30973	nmod	1α,mice
R6662	T31093	T31094	det	the,properties
R6663	T31094	T31091	pobj	properties,due
R6664	T31095	T31094	amod	insulating,properties
R6665	T30976	T30975	punct	-,1α
R6666	T31096	T31094	prep	of,properties
R6667	T31097	T31098	amod	increased,mass
R6668	T31098	T31096	pobj	mass,of
R6669	T30977	T30975	punct	−,1α
R6670	T31099	T31098	compound	body,mass
R6671	T31100	T31080	punct	.,exhibit
R6672	T30978	T30975	punct	/,1α
R6673	T31102	T31103	advmod	Collectively,demonstrate
R6674	T30979	T30975	punct	−,1α
R6675	T31104	T31103	punct	", ",demonstrate
R6676	T31105	T31106	det	these,results
R6677	T31106	T31103	nsubj	results,demonstrate
R6678	T30980	T30970	prep	to,exposure
R6679	T31107	T31108	det	the,importance
R6680	T31108	T31103	dobj	importance,demonstrate
R6681	T31109	T31108	prep	of,importance
R6682	T30981	T30980	pobj	cold,to
R6683	T31110	T31111	compound	PGC,1α
R6684	T30982	T30981	punct	", ",cold
R6685	T31111	T31109	pobj	1α,of
R6686	T30983	T30984	det	another,stress
R6687	T31112	T31111	punct	-,1α
R6688	T31113	T31108	prep	as,importance
R6689	T30984	T30981	appos	stress,cold
R6690	T31114	T31115	det	a,transducer
R6691	T31115	T31113	pobj	transducer,as
R6692	T31116	T31115	amod	key,transducer
R6693	T30985	T30984	amod	relevant,stress
R6694	T31117	T31115	prep	of,transducer
R6695	T31118	T31119	amod	physiologic,stimuli
R6696	T31119	T31117	pobj	stimuli,of
R6697	T30986	T30984	amod	physiologic,stress
R6698	T31120	T31115	prep	to,transducer
R6699	T30987	T30969	punct	", ",resulted
R6700	T30988	T30969	prep	in,resulted
R6701	T30989	T30990	det	an,drop
R6702	T31121	T31122	det	the,control
R6703	T31122	T31120	pobj	control,to
R6704	T30990	T30988	pobj	drop,in
R6705	T31123	T31122	prep	of,control
R6706	T31124	T31125	compound	energy,metabolism
R6707	T30991	T30990	amod	untoward,drop
R6708	T31125	T31123	pobj	metabolism,of
R6709	T31126	T31103	punct	.,demonstrate
R6710	T30992	T30990	prep	in,drop
R6711	T31128	T31129	det	The,observation
R6712	T31129	T31130	nsubj	observation,is
R6713	T30993	T30994	compound	core,temperature
R6714	T31131	T31129	prep	of,observation
R6715	T31132	T31133	npadvmod	fasting,induced
R6716	T30994	T30992	pobj	temperature,in
R6717	T31133	T31135	amod	induced,steatosis
R6718	T31134	T31133	punct	-,induced
R6719	T31135	T31131	pobj	steatosis,of
R6720	T30995	T30994	compound	body,temperature
R6721	T31136	T31135	amod	hepatic,steatosis
R6722	T31137	T31138	det	another,example
R6723	T31138	T31130	attr	example,is
R6724	T30996	T30969	advcl	consistent,resulted
R6725	T31139	T31138	prep	of,example
R6726	T31140	T31141	det	the,inability
R6727	T30997	T30996	prep	with,consistent
R6728	T31141	T31139	pobj	inability,of
R6729	T31142	T31141	prep	of,inability
R6730	T31143	T31144	nmod	PGC,1α
R6731	T30998	T30999	det	an,abnormality
R6732	T31144	T31146	nmod	1α,mice
R6733	T31145	T31144	punct	-,1α
R6734	T30999	T30997	pobj	abnormality,with
R6735	T31146	T31142	pobj	mice,of
R6736	T31147	T31144	punct	−,1α
R6737	T31148	T31144	punct	/,1α
R6738	T31000	T30999	prep	in,abnormality
R6739	T31149	T31144	punct	−,1α
R6740	T31150	T31151	aux	to,respond
R6741	T31151	T31141	acl	respond,inability
R6742	T31001	T31000	pobj	thermogenesis,in
R6743	T31152	T31151	prep	to,respond
R6744	T31153	T31154	amod	postnatal,environmental
R6745	T31154	T31155	amod	environmental,demands
R6746	T31002	T30996	prep	despite,consistent
R6747	T31155	T31152	pobj	demands,to
R6748	T31156	T31155	amod	metabolic,demands
R6749	T31157	T31130	punct	.,is
R6750	T31003	T31004	amod	normal,induction
R6751	T31159	T31160	prep	Following,found
R6752	T31161	T31162	amod	short,term
R6753	T31162	T31164	compound	term,starvation
R6754	T31163	T31162	punct	-,term
R6755	T31004	T31002	pobj	induction,despite
R6756	T31164	T31159	pobj	starvation,Following
R6757	T31165	T31160	punct	", ",found
R6758	T31005	T31004	compound	cold,induction
R6759	T31166	T31160	nsubj	we,found
R6760	T31167	T31168	mark	that,developed
R6761	T31168	T31160	ccomp	developed,found
R6762	T31006	T31004	prep	of,induction
R6763	T31169	T31170	det	the,mice
R6764	T31170	T31168	nsubj	mice,developed
R6765	T31007	T31008	nmod	UCP,mRNA
R6766	T31171	T31172	nmod	PGC,1α
R6767	T31008	T31006	pobj	mRNA,of
R6768	T31172	T31170	nmod	1α,mice
R6769	T31009	T31007	punct	-,UCP
R6770	T31173	T31172	punct	-,1α
R6771	T31010	T31007	nummod	1,UCP
R6772	T31174	T31172	punct	−,1α
R6773	T31175	T31172	punct	/,1α
R6774	T31176	T31172	punct	−,1α
R6775	T31011	T31004	prep	in,induction
R6776	T31177	T31178	amod	marked,accumulation
R6777	T31178	T31168	dobj	accumulation,developed
R6778	T31012	T31011	pobj	BAT,in
R6779	T31179	T31180	compound	hepatocyte,triglyceride
R6780	T31180	T31178	compound	triglyceride,accumulation
R6781	T31181	T31160	punct	.,found
R6782	T31013	T30965	punct	.,found
R6783	T31183	T31184	advmod	Further,analysis
R6784	T31184	T31185	nsubj	analysis,revealed
R6785	T31227	T31228	amod	null,hepatocytes
R6786	T31186	T31187	mark	that,reduced
R6787	T31187	T31185	ccomp	reduced,revealed
R6788	T31188	T31189	compound	palmitate,oxidation
R6789	T31228	T31223	pobj	hepatocytes,in
R6790	T31189	T31190	compound	oxidation,rates
R6791	T31190	T31187	nsubjpass	rates,reduced
R6792	T31191	T31187	auxpass	were,reduced
R6793	T31192	T31187	prep	in,reduced
R6794	T31229	T31214	neg	not,was
R6795	T31193	T31192	pobj	hepatocytes,in
R6796	T31194	T31193	acl	isolated,hepatocytes
R6797	T31230	T31214	prep	due,was
R6798	T31195	T31194	prep	from,isolated
R6799	T31196	T31197	det	the,mice
R6800	T31231	T31230	pcomp	to,due
R6801	T31197	T31195	pobj	mice,from
R6802	T31232	T31233	amod	altered,expression
R6803	T31198	T31199	nmod	PGC,1α
R6804	T31199	T31197	nmod	1α,mice
R6805	T31200	T31199	punct	-,1α
R6806	T31201	T31199	punct	−,1α
R6807	T31202	T31199	punct	/,1α
R6808	T31233	T31230	pobj	expression,due
R6809	T31203	T31199	punct	−,1α
R6810	T31204	T31187	punct	", ",reduced
R6811	T31205	T31206	dep	which,predispose
R6812	T31234	T31233	prep	of,expression
R6813	T31206	T31187	advcl	predispose,reduced
R6814	T31207	T31206	aux	would,predispose
R6815	T31235	T31236	nmod	PGC,1α
R6816	T31208	T31206	prep	to,predispose
R6817	T31209	T31210	compound	lipid,accumulation
R6818	T31236	T31238	nmod	1α,genes
R6819	T31210	T31208	pobj	accumulation,to
R6820	T31211	T31185	punct	.,revealed
R6821	T31237	T31236	punct	-,1α
R6822	T31213	T31214	advmod	Surprisingly,was
R6823	T31238	T31234	pobj	genes,of
R6824	T31215	T31214	punct	", ",was
R6825	T31216	T31217	det	the,reduction
R6826	T31239	T31236	punct	/,1α
R6827	T31217	T31214	nsubj	reduction,was
R6828	T31218	T31217	prep	in,reduction
R6829	T31219	T31220	amod	fatty,acid
R6830	T31240	T31236	appos	PPAR,1α
R6831	T31220	T31221	compound	acid,rates
R6832	T31221	T31218	pobj	rates,in
R6833	T31222	T31221	compound	oxidation,rates
R6834	T31241	T31238	compound	target,genes
R6835	T31223	T31217	prep	in,reduction
R6836	T31224	T31225	compound	PGC,1α
R6837	T31225	T31227	npadvmod	1α,null
R6838	T31242	T31238	acl	involved,genes
R6839	T31226	T31225	punct	-,1α
R6840	T31243	T31242	prep	in,involved
R6841	T31244	T31245	amod	mitochondrial,oxidation
R6842	T31245	T31243	pobj	oxidation,in
R6843	T31246	T31247	amod	fatty,acid
R6844	T31333	T31326	prep	to,contribution
R6845	T31247	T31245	compound	acid,oxidation
R6846	T31334	T31335	det	the,phenotype
R6847	T31248	T31214	punct	.,was
R6848	T31335	T31333	pobj	phenotype,to
R6849	T31336	T31335	amod	steatotic,phenotype
R6850	T31337	T31323	aux	can,discerned
R6851	T31250	T31251	advmod	However,diminished
R6852	T31338	T31323	neg	not,discerned
R6853	T31339	T31323	auxpass	be,discerned
R6854	T31340	T31323	advmod	fully,discerned
R6855	T31341	T31323	prep	from,discerned
R6856	T31342	T31343	poss	our,data
R6857	T31343	T31341	pobj	data,from
R6858	T31252	T31251	punct	", ",diminished
R6859	T31344	T31323	punct	", ",discerned
R6860	T31345	T31323	prep	given,discerned
R6861	T31346	T31347	mark	that,reflect
R6862	T31347	T31345	pcomp	reflect,given
R6863	T31348	T31349	det	this,response
R6864	T31253	T31254	amod	mitochondrial,rates
R6865	T31349	T31347	nsubj	response,reflect
R6866	T31350	T31347	aux	could,reflect
R6867	T31254	T31251	nsubjpass	rates,diminished
R6868	T31351	T31352	det	the,effects
R6869	T31352	T31347	dobj	effects,reflect
R6870	T31353	T31352	amod	direct,effects
R6871	T31255	T31254	amod	respiratory,rates
R6872	T31354	T31352	prep	of,effects
R6873	T31355	T31356	compound	PGC,1α
R6874	T31256	T31251	auxpass	were,diminished
R6875	T31356	T31358	compound	1α,deficiency
R6876	T31357	T31356	punct	-,1α
R6877	T31358	T31354	pobj	deficiency,of
R6878	T31257	T31251	punct	.,diminished
R6879	T31359	T31352	prep	on,effects
R6880	T31360	T31361	compound	target,genes
R6881	T31259	T31260	prep	In,found
R6882	T31361	T31359	pobj	genes,on
R6883	T31362	T31347	cc	or,reflect
R6884	T31363	T31364	det	a,response
R6885	T31364	T31347	conj	response,reflect
R6886	T31261	T31259	pobj	addition,In
R6887	T31365	T31364	amod	secondary,response
R6888	T31366	T31364	amod	compensatory,response
R6889	T31367	T31364	prep	to,response
R6890	T31368	T31369	nmod	hepatocyte,accumulation
R6891	T31262	T31260	punct	", ",found
R6892	T31263	T31260	nsubj	we,found
R6893	T31369	T31367	pobj	accumulation,to
R6894	T31370	T31371	amod	fatty,acid
R6895	T31264	T31265	mark	that,activated
R6896	T31371	T31369	compound	acid,accumulation
R6897	T31372	T31323	punct	.,discerned
R6898	T31265	T31260	ccomp	activated,found
R6899	T31374	T31375	advcl	Consistent,indicates
R6900	T31266	T31267	compound	triglyceride,synthesis
R6901	T31376	T31374	prep	with,Consistent
R6902	T31377	T31378	det	the,possibility
R6903	T31267	T31265	nsubjpass	synthesis,activated
R6904	T31378	T31376	pobj	possibility,with
R6905	T31379	T31378	amod	former,possibility
R6906	T31268	T31265	auxpass	was,activated
R6907	T31380	T31375	punct	", ",indicates
R6908	T31381	T31382	amod	recent,evidence
R6909	T31382	T31375	nsubj	evidence,indicates
R6910	T31383	T31384	mark	that,coactivates
R6911	T31384	T31375	ccomp	coactivates,indicates
R6912	T31269	T31265	advmod	abnormally,activated
R6914	T31386	T31384	nsubj	1α,coactivates
R6915	T31387	T31386	punct	-,1α
R6916	T31270	T31265	punct	", ",activated
R6918	T31389	T31384	dobj	receptor,coactivates
R6919	T31271	T31265	cc	and,activated
R6920	T31390	T31389	amod	nuclear,receptor
R6921	T31391	T31389	appos	FXR,receptor
R6922	T31392	T31389	punct	", ",receptor
R6923	T31272	T31273	det	the,expression
R6924	T31393	T31394	det	a,regulator
R6925	T31394	T31389	appos	regulator,receptor
R6926	T31273	T31274	nsubj	expression,failed
R6927	T31395	T31394	amod	negative,regulator
R6928	T31396	T31394	prep	of,regulator
R6929	T31397	T31398	compound	SREBP,1c
R6930	T31274	T31265	conj	failed,activated
R6931	T31398	T31400	compound	1c,expression
R6932	T31399	T31398	punct	-,1c
R6933	T31400	T31396	pobj	expression,of
R6934	T31275	T31273	prep	of,expression
R6935	T31401	T31400	cc	and,expression
R6936	T31402	T31403	compound	triglyceride,synthesis
R6937	T31403	T31400	conj	synthesis,expression
R6938	T31276	T31275	pobj	genes,of
R6939	T31404	T31405	punct	[,33
R6940	T31405	T31375	parataxis	33,indicates
R6941	T31406	T31405	punct	],33
R6942	T31277	T31276	acl	encoding,genes
R6943	T31407	T31375	punct	.,indicates
R6944	T31278	T31279	compound	SREBP,1c
R6945	T31409	T31410	nsubj	We,conclude
R6946	T31411	T31412	mark	that,result
R6947	T31279	T31277	dobj	1c,encoding
R6948	T31412	T31410	ccomp	result,conclude
R6949	T31413	T31414	amod	reduced,capacity
R6950	T31280	T31279	punct	-,1c
R6951	T31414	T31412	nsubj	capacity,result
R6952	T31415	T31414	nmod	hepatocyte,capacity
R6953	T31416	T31414	amod	mitochondrial,capacity
R6954	T31281	T31279	cc	and,1c
R6955	T31417	T31414	amod	respiratory,capacity
R6956	T31418	T31414	punct	", ",capacity
R6957	T31419	T31414	cc	and,capacity
R6958	T31282	T31279	conj	SCD,1c
R6959	T31420	T31421	advmod	possibly,activation
R6960	T31421	T31414	conj	activation,capacity
R6961	T31422	T31421	prep	of,activation
R6962	T31423	T31424	amod	lipogenic,programs
R6963	T31424	T31422	pobj	programs,of
R6964	T31283	T31282	punct	-,SCD
R6965	T31425	T31412	punct	", ",result
R6966	T31426	T31412	prep	in,result
R6967	T31427	T31428	compound	hepatocyte,triglyceride
R6968	T31284	T31282	nummod	1,SCD
R6969	T31428	T31429	compound	triglyceride,accumulation
R6970	T31429	T31426	pobj	accumulation,in
R6971	T31430	T31412	prep	in,result
R6972	T31285	T31279	punct	", ",1c
R6973	T31431	T31432	det	the,context
R6974	T31432	T31430	pobj	context,in
R6975	T31433	T31432	prep	of,context
R6976	T31434	T31435	amod	increased,delivery
R6977	T31286	T31287	amod	key,proteins
R6978	T31435	T31433	pobj	delivery,of
R6979	T31436	T31435	amod	hepatic,delivery
R6980	T31287	T31279	appos	proteins,1c
R6981	T31437	T31435	prep	of,delivery
R6982	T31438	T31439	amod	fatty,acids
R6983	T31288	T31287	prep	in,proteins
R6984	T31289	T31290	det	the,pathway
R6985	T31439	T31437	pobj	acids,of
R6986	T31440	T31435	amod	such,delivery
R6987	T31290	T31288	pobj	pathway,in
R6988	T31441	T31442	mark	as,occurs
R6989	T31442	T31440	advcl	occurs,such
R6990	T31291	T31292	amod	hepatic,lipogenic
R6991	T31443	T31442	prep	with,occurs
R6992	T31444	T31443	pobj	fasting,with
R6993	T31445	T31410	punct	.,conclude
R6994	T31292	T31290	amod	lipogenic,pathway
R6995	T31447	T31448	nsubj	We,found
R6996	T31293	T31274	punct	", ",failed
R6997	T31449	T31450	mark	that,exhibit
R6998	T31294	T31295	aux	to,regulated
R6999	T31295	T31274	xcomp	regulated,failed
R7000	T31450	T31448	ccomp	exhibit,found
R7001	T31451	T31450	prep	after,exhibit
R7002	T31452	T31453	nummod	18,wk
R7003	T31296	T31295	auxpass	be,regulated
R7004	T31453	T31451	pobj	wk,after
R7005	T31454	T31453	prep	of,wk
R7006	T31455	T31454	pobj	age,of
R7007	T31297	T31295	advmod	appropriately,regulated
R7008	T31456	T31450	punct	", ",exhibit
R7009	T31457	T31458	amod	female,mice
R7010	T31458	T31450	nsubj	mice,exhibit
R7011	T31459	T31460	nmod	PGC,1α
R7012	T31460	T31458	nmod	1α,mice
R7013	T31298	T31295	advmod	down,regulated
R7014	T31461	T31460	punct	-,1α
R7015	T31462	T31460	punct	−,1α
R7016	T31463	T31460	punct	/,1α
R7017	T31464	T31460	punct	−,1α
R7018	T31299	T31295	punct	-,regulated
R7019	T31465	T31466	det	a,increase
R7020	T31300	T31295	prep	in,regulated
R7021	T31466	T31450	dobj	increase,exhibit
R7022	T31467	T31466	amod	mild,increase
R7023	T31468	T31467	cc	but,mild
R7024	T31301	T31302	amod	fasted,mice
R7025	T31469	T31470	advmod	significantly,abnormal
R7026	T31470	T31467	conj	abnormal,mild
R7027	T31471	T31466	compound	weight,increase
R7028	T31302	T31300	pobj	mice,in
R7029	T31472	T31466	acl	associated,increase
R7030	T31473	T31472	prep	with,associated
R7031	T31474	T31475	amod	increased,stores
R7032	T31303	T31304	nmod	PGC,1α
R7033	T31475	T31473	pobj	stores,with
R7034	T31476	T31475	compound	fat,stores
R7035	T31304	T31302	nmod	1α,mice
R7036	T31477	T31448	punct	.,found
R7037	T31479	T31480	amod	Lean,mass
R7038	T31305	T31304	punct	-,1α
R7039	T31480	T31481	nsubj	mass,was
R7040	T31306	T31304	punct	−,1α
R7041	T31482	T31481	acomp	unchanged,was
R7042	T31483	T31481	prep	at,was
R7043	T31484	T31485	det	the,points
R7044	T31307	T31304	punct	/,1α
R7045	T31485	T31483	pobj	points,at
R7046	T31486	T31485	compound	time,points
R7047	T31487	T31485	acl	examined,points
R7048	T31308	T31304	punct	−,1α
R7049	T31488	T31481	punct	.,was
R7050	T31490	T31491	prep	With,noted
R7051	T31309	T31260	punct	.,found
R7052	T31492	T31493	amod	further,aging
R7053	T31311	T31312	det	The,mechanism
R7054	T31493	T31490	pobj	aging,With
R7055	T31494	T31491	punct	", ",noted
R7056	T31495	T31496	det	a,increase
R7057	T31496	T31491	nsubjpass	increase,noted
R7058	T31312	T31313	nsubj	mechanism,is
R7059	T31497	T31496	amod	modest,increase
R7060	T31498	T31497	cc	but,modest
R7061	T31499	T31497	conj	significant,modest
R7062	T31314	T31312	acl	involved,mechanism
R7063	T31500	T31496	prep	in,increase
R7064	T31501	T31502	compound	body,fat
R7065	T31502	T31500	pobj	fat,in
R7066	T31503	T31491	auxpass	was,noted
R7067	T31504	T31491	advmod	also,noted
R7068	T31505	T31491	prep	in,noted
R7069	T31315	T31314	prep	in,involved
R7070	T31506	T31507	amod	male,mice
R7071	T31507	T31505	pobj	mice,in
R7072	T31508	T31509	nmod	PGC,1α
R7073	T31316	T31317	det	this,finding
R7074	T31509	T31507	nmod	1α,mice
R7075	T31510	T31509	punct	-,1α
R7076	T31317	T31315	pobj	finding,in
R7077	T31511	T31509	punct	−,1α
R7078	T31512	T31509	punct	/,1α
R7079	T31513	T31509	punct	−,1α
R7080	T31318	T31317	amod	latter,finding
R7081	T31514	T31515	punct	(,data
R7082	T31515	T31491	parataxis	data,noted
R7083	T31516	T31515	amod	unpublished,data
R7084	T31319	T31313	acomp	unknown,is
R7085	T31517	T31515	punct	),data
R7086	T31518	T31491	punct	.,noted
R7087	T31320	T31313	punct	.,is
R7088	T31520	T31521	det	The,basis
R7089	T31521	T31522	nsubj	basis,is
R7090	T31322	T31323	advmod	Indeed,discerned
R7091	T31523	T31521	prep	for,basis
R7092	T31524	T31525	det	the,abnormalities
R7093	T31525	T31523	pobj	abnormalities,for
R7094	T31526	T31525	amod	observed,abnormalities
R7095	T31324	T31323	punct	", ",discerned
R7096	T31527	T31525	prep	in,abnormalities
R7097	T31528	T31529	compound	weight,control
R7098	T31529	T31527	pobj	control,in
R7099	T31325	T31326	det	the,contribution
R7100	T31530	T31522	acomp	unknown,is
R7101	T31531	T31522	punct	.,is
R7102	T31326	T31323	nsubjpass	contribution,discerned
R7103	T31533	T31534	nsubj	We,find
R7104	T31327	T31326	amod	relative,contribution
R7105	T31535	T31534	aux	did,find
R7106	T31536	T31534	neg	not,find
R7107	T31537	T31534	dobj	differences,find
R7108	T31328	T31326	prep	of,contribution
R7109	T31538	T31537	prep	in,differences
R7110	T31539	T31540	compound	food,intake
R7111	T31540	T31538	pobj	intake,in
R7112	T31329	T31330	amod	increased,rates
R7113	T31541	T31540	cc	or,intake
R7114	T31542	T31543	compound	activity,levels
R7115	T31543	T31540	conj	levels,intake
R7116	T31544	T31534	prep	in,find
R7117	T31330	T31328	pobj	rates,of
R7118	T31331	T31332	compound	triglyceride,synthesis
R7119	T31332	T31330	compound	synthesis,rates
R7120	T31545	T31546	amod	female,mice
R7121	T31651	T31650	cc	and,control
R7122	T31546	T31544	pobj	mice,in
R7123	T31547	T31548	nmod	PGC,1α
R7124	T31652	T31653	compound	fat,distribution
R7125	T31548	T31546	nmod	1α,mice
R7126	T31549	T31548	punct	-,1α
R7127	T31550	T31548	punct	−,1α
R7128	T31653	T31650	conj	distribution,control
R7129	T31551	T31548	punct	/,1α
R7130	T31552	T31548	punct	−,1α
R7131	T31654	T31615	punct	.,be
R7132	T31553	T31534	punct	.,find
R7133	T31555	T31556	nsubj	It,is
R7134	T31656	T31657	nsubj	We,find
R7135	T31557	T31556	acomp	possible,is
R7136	T31558	T31559	mark	that,leads
R7137	T31658	T31657	aux	did,find
R7138	T31559	T31556	ccomp	leads,is
R7139	T31560	T31561	det	a,reduction
R7140	T31561	T31559	nsubj	reduction,leads
R7141	T31659	T31657	neg	not,find
R7142	T31562	T31561	prep	in,reduction
R7143	T31563	T31564	amod	systemic,utilization
R7144	T31564	T31562	pobj	utilization,in
R7145	T31660	T31657	dobj	evidence,find
R7146	T31565	T31564	compound	energy,utilization
R7147	T31661	T31660	prep	for,evidence
R7148	T31662	T31663	compound	glucose,intolerance
R7149	T31566	T31561	punct	", ",reduction
R7150	T31567	T31561	acl	related,reduction
R7151	T31663	T31661	pobj	intolerance,for
R7152	T31568	T31567	prep	to,related
R7153	T31569	T31570	det	the,dysfunction
R7154	T31664	T31663	cc	or,intolerance
R7155	T31570	T31568	pobj	dysfunction,to
R7156	T31571	T31570	amod	mitochondrial,dysfunction
R7157	T31572	T31559	punct	", ",leads
R7158	T31665	T31666	compound	insulin,resistance
R7159	T31573	T31559	prep	to,leads
R7160	T31574	T31575	amod	increased,mass
R7161	T31575	T31573	pobj	mass,to
R7162	T31666	T31663	conj	resistance,intolerance
R7163	T31576	T31575	compound	fat,mass
R7164	T31577	T31575	cc	and,mass
R7165	T31667	T31657	prep	in,find
R7166	T31578	T31579	compound	weight,gain
R7167	T31579	T31575	conj	gain,mass
R7168	T31580	T31559	prep	in,leads
R7169	T31581	T31582	det	the,mice
R7170	T31582	T31580	pobj	mice,in
R7171	T31583	T31584	nmod	PGC,1α
R7172	T31668	T31669	det	the,animals
R7173	T31584	T31582	nmod	1α,mice
R7174	T31585	T31584	punct	-,1α
R7175	T31586	T31584	punct	−,1α
R7176	T31669	T31667	pobj	animals,in
R7177	T31587	T31584	punct	/,1α
R7178	T31588	T31584	punct	−,1α
R7179	T31670	T31671	nmod	PGC,1α
R7180	T31589	T31556	punct	.,is
R7181	T31591	T31592	advmod	Interestingly,reported
R7182	T31671	T31669	nmod	1α,animals
R7183	T31593	T31592	punct	", ",reported
R7184	T31672	T31671	punct	-,1α
R7185	T31594	T31595	det	an,association
R7186	T31595	T31592	nsubjpass	association,reported
R7187	T31596	T31595	prep	between,association
R7188	T31673	T31671	punct	−,1α
R7189	T31597	T31598	compound	PGC,1α
R7190	T31598	T31600	compound	1α,polymorphisms
R7191	T31599	T31598	punct	-,1α
R7192	T31674	T31671	punct	/,1α
R7193	T31600	T31596	pobj	polymorphisms,between
R7194	T31601	T31600	compound	gene,polymorphisms
R7195	T31675	T31671	punct	−,1α
R7196	T31602	T31600	cc	and,polymorphisms
R7197	T31603	T31600	conj	obesity,polymorphisms
R7198	T31604	T31595	prep	in,association
R7199	T31676	T31669	prep	on,animals
R7200	T31605	T31604	pobj	humans,in
R7201	T31606	T31592	aux	has,reported
R7202	T31607	T31592	auxpass	been,reported
R7203	T31677	T31678	amod	standard,chow
R7204	T31608	T31592	advmod	recently,reported
R7205	T31609	T31610	punct	[,26
R7206	T31610	T31592	parataxis	26,reported
R7207	T31678	T31676	pobj	chow,on
R7208	T31611	T31610	punct	],26
R7209	T31612	T31592	punct	.,reported
R7210	T31679	T31657	punct	.,find
R7211	T31614	T31615	advmod	Clearly,be
R7212	T31681	T31682	advmod	Moreover,were
R7213	T31616	T31615	punct	", ",be
R7214	T31617	T31618	amod	future,studies
R7215	T31618	T31615	nsubj	studies,be
R7216	T31683	T31682	punct	", ",were
R7217	T31619	T31618	prep	of,studies
R7218	T31620	T31621	amod	male,mice
R7219	T31621	T31619	pobj	mice,of
R7220	T31622	T31620	cc	and,male
R7221	T31623	T31620	conj	female,male
R7222	T31624	T31625	nmod	PGC,1α
R7223	T31684	T31685	amod	female,mice
R7224	T31625	T31621	nmod	1α,mice
R7225	T31626	T31625	punct	-,1α
R7226	T31627	T31625	punct	−,1α
R7227	T31685	T31682	nsubj	mice,were
R7228	T31628	T31625	punct	/,1α
R7229	T31629	T31625	punct	−,1α
R7230	T31686	T31687	nmod	PGC,1α
R7231	T31630	T31621	prep	in,mice
R7232	T31631	T31632	amod	pure,strain
R7233	T31687	T31685	nmod	1α,mice
R7234	T31632	T31634	compound	strain,backgrounds
R7235	T31688	T31687	punct	-,1α
R7236	T31633	T31632	punct	-,strain
R7237	T31634	T31630	pobj	backgrounds,in
R7238	T31635	T31621	prep	over,mice
R7239	T31689	T31687	punct	−,1α
R7240	T31636	T31637	det	a,range
R7241	T31637	T31635	pobj	range,over
R7242	T31638	T31637	prep	of,range
R7243	T31690	T31687	punct	/,1α
R7244	T31639	T31638	pobj	ages,of
R7245	T31640	T31615	aux	will,be
R7246	T31641	T31615	acomp	necessary,be
R7247	T31691	T31687	punct	−,1α
R7248	T31642	T31643	aux	to,investigate
R7249	T31643	T31615	advcl	investigate,be
R7250	T31692	T31693	advmod	more,tolerant
R7251	T31644	T31643	advmod	fully,investigate
R7252	T31645	T31646	det	the,abnormalities
R7253	T31693	T31682	acomp	tolerant,were
R7254	T31646	T31643	dobj	abnormalities,investigate
R7255	T31647	T31646	amod	observed,abnormalities
R7256	T31648	T31646	prep	in,abnormalities
R7257	T31694	T31693	npadvmod	glucose,tolerant
R7258	T31649	T31650	compound	weight,control
R7259	T31650	T31648	pobj	control,in
R7260	T31695	T31693	punct	-,tolerant
R7261	T31696	T31693	cc	and,tolerant
R7262	T31697	T31698	npadvmod	insulin,sensitive
R7263	T31698	T31693	conj	sensitive,tolerant
R7264	T31756	T31757	amod	metabolic,regulatory
R7265	T31699	T31698	punct	-,sensitive
R7266	T31757	T31755	amod	regulatory,mechanisms
R7267	T31758	T31753	aux	have,activated
R7268	T31700	T31693	prep	than,tolerant
R7269	T31759	T31753	auxpass	been,activated
R7270	T31760	T31753	prep	in,activated
R7271	T31761	T31762	det	the,mice
R7272	T31762	T31760	pobj	mice,in
R7273	T31763	T31764	compound	PGC,1α
R7274	T31701	T31702	nmod	PGC,1α
R7275	T31764	T31766	npadvmod	1α,deficient
R7276	T31765	T31764	punct	-,1α
R7277	T31766	T31762	amod	deficient,mice
R7278	T31702	T31704	nmod	1α,controls
R7279	T31767	T31766	punct	-,deficient
R7280	T31768	T31753	punct	", ",activated
R7281	T31769	T31753	advcl	accounting,activated
R7282	T31703	T31702	punct	-,1α
R7283	T31770	T31769	prep	for,accounting
R7284	T31771	T31772	det	this,observation
R7285	T31704	T31700	pobj	controls,than
R7286	T31772	T31770	pobj	observation,for
R7287	T31773	T31749	punct	.,is
R7288	T31705	T31702	punct	+,1α
R7289	T31775	T31776	advmod	Alternatively,serve
R7290	T31706	T31702	punct	/,1α
R7291	T31777	T31776	punct	", ",serve
R7292	T31778	T31779	compound	PGC,1α
R7293	T31779	T31776	nsubj	1α,serve
R7294	T31707	T31702	punct	+,1α
R7295	T31780	T31779	punct	-,1α
R7296	T31781	T31776	aux	could,serve
R7297	T31708	T31709	advmod	when,consuming
R7298	T31782	T31776	prep	as,serve
R7299	T31783	T31784	det	a,coactivator
R7300	T31784	T31782	pobj	coactivator,as
R7301	T31709	T31682	advcl	consuming,were
R7302	T31785	T31784	prep	of,coactivator
R7303	T31786	T31785	pobj	factors,of
R7304	T31710	T31711	det	a,diet
R7305	T31787	T31788	dep	that,mediate
R7306	T31788	T31786	relcl	mediate,factors
R7307	T31711	T31709	dobj	diet,consuming
R7308	T31789	T31790	npadvmod	diet,induced
R7309	T31790	T31792	amod	induced,resistance
R7310	T31791	T31790	punct	-,induced
R7311	T31712	T31713	amod	high,fat
R7312	T31792	T31788	dobj	resistance,mediate
R7313	T31793	T31792	compound	insulin,resistance
R7314	T31713	T31711	compound	fat,diet
R7315	T31794	T31776	punct	.,serve
R7316	T31796	T31797	advcl	Consistent,shown
R7317	T31714	T31713	punct	-,fat
R7318	T31798	T31796	prep	with,Consistent
R7319	T31799	T31800	det	this,notion
R7320	T31715	T31682	punct	.,were
R7321	T31800	T31798	pobj	notion,with
R7322	T31801	T31797	punct	", ",shown
R7323	T31802	T31797	nsubj	we,shown
R7324	T31803	T31802	cc	and,we
R7325	T31804	T31802	conj	others,we
R7326	T31717	T31718	det	These,findings
R7327	T31805	T31797	aux	have,shown
R7328	T31806	T31807	mark	that,exhibit
R7329	T31718	T31719	nsubj	findings,are
R7330	T31807	T31797	ccomp	exhibit,shown
R7331	T31720	T31719	acomp	surprising,are
R7332	T31808	T31807	nsubj	mice,exhibit
R7333	T31809	T31808	acl	lacking,mice
R7334	T31810	T31811	det	the,target
R7335	T31811	T31809	dobj	target,lacking
R7336	T31721	T31719	punct	", ",are
R7337	T31812	T31813	compound	PGC,1α
R7338	T31813	T31811	compound	1α,target
R7339	T31814	T31813	punct	-,1α
R7340	T31722	T31719	prep	given,are
R7341	T31815	T31811	appos	PPAR,target
R7342	T31816	T31807	dobj	resistance,exhibit
R7343	T31723	T31724	det	the,results
R7344	T31817	T31816	prep	to,resistance
R7345	T31818	T31819	npadvmod	diet,induced
R7346	T31819	T31821	amod	induced,intolerance
R7347	T31724	T31722	pobj	results,given
R7348	T31820	T31819	punct	-,induced
R7349	T31821	T31817	pobj	intolerance,to
R7350	T31725	T31724	prep	of,results
R7351	T31822	T31821	compound	glucose,intolerance
R7352	T31823	T31824	punct	[,36
R7353	T31824	T31797	parataxis	36,shown
R7354	T31726	T31727	amod	several,studies
R7355	T31825	T31824	nummod	21,36
R7356	T31826	T31824	punct	",",36
R7357	T31827	T31824	nummod	35,36
R7358	T31727	T31725	pobj	studies,of
R7359	T31828	T31824	punct	",",36
R7360	T31829	T31824	punct	],36
R7361	T31728	T31727	amod	recent,studies
R7362	T31830	T31797	punct	.,shown
R7363	T31832	T31833	amod	Histologic,surveys
R7364	T31729	T31727	acl	demonstrating,studies
R7365	T31833	T31834	nsubj	surveys,revealed
R7366	T31835	T31833	prep	of,surveys
R7367	T31730	T31731	amod	reduced,expression
R7368	T31836	T31837	det	the,mice
R7369	T31837	T31835	pobj	mice,of
R7370	T31838	T31839	nmod	PGC,1α
R7371	T31731	T31729	dobj	expression,demonstrating
R7372	T31839	T31837	nmod	1α,mice
R7373	T31840	T31839	punct	-,1α
R7374	T31841	T31839	punct	−,1α
R7375	T31842	T31839	punct	/,1α
R7376	T31843	T31839	punct	−,1α
R7377	T31732	T31731	prep	of,expression
R7378	T31844	T31845	amod	ultrastructural,abnormalities
R7379	T31845	T31834	dobj	abnormalities,revealed
R7380	T31846	T31834	prep	in,revealed
R7381	T31733	T31734	compound	PGC,1α
R7382	T31847	T31848	det	the,system
R7383	T31848	T31846	pobj	system,in
R7384	T31849	T31848	amod	central,system
R7385	T31734	T31732	pobj	1α,of
R7386	T31850	T31848	amod	nervous,system
R7387	T31851	T31834	punct	.,revealed
R7388	T31735	T31734	punct	-,1α
R7389	T31853	T31854	nsubj	Inspection,revealed
R7390	T31736	T31729	prep	in,demonstrating
R7391	T31855	T31853	prep	of,Inspection
R7392	T31856	T31855	pobj	sections,of
R7393	T31857	T31856	acl	prepared,sections
R7394	T31737	T31738	amod	human,muscle
R7395	T31858	T31857	prep	from,prepared
R7396	T31859	T31860	det	the,brains
R7397	T31860	T31858	pobj	brains,from
R7398	T31738	T31736	pobj	muscle,in
R7399	T31861	T31860	prep	of,brains
R7400	T31739	T31738	amod	diabetic,muscle
R7401	T31740	T31738	amod	skeletal,muscle
R7402	T31862	T31863	nmod	PGC,1α
R7403	T31741	T31742	punct	[,34
R7404	T31863	T31865	nmod	1α,mice
R7405	T31864	T31863	punct	-,1α
R7406	T31742	T31719	parataxis	34,are
R7407	T31865	T31861	pobj	mice,of
R7408	T31866	T31863	punct	−,1α
R7409	T31867	T31863	punct	/,1α
R7410	T31743	T31742	nummod	24,34
R7411	T31868	T31863	punct	−,1α
R7412	T31869	T31870	amod	patchy,areas
R7413	T31744	T31742	punct	",",34
R7414	T31870	T31854	dobj	areas,revealed
R7415	T31871	T31870	prep	of,areas
R7416	T31872	T31871	pobj	microvacuolation,of
R7417	T31745	T31742	punct	],34
R7418	T31873	T31870	prep	in,areas
R7419	T31874	T31875	det	the,neurons
R7420	T31746	T31719	punct	.,are
R7421	T31875	T31873	pobj	neurons,in
R7422	T31876	T31875	amod	pyramidal,neurons
R7423	T31877	T31875	prep	of,neurons
R7424	T31748	T31749	nsubj	It,is
R7425	T31878	T31879	det	the,cortex
R7426	T31879	T31877	pobj	cortex,of
R7427	T31880	T31879	amod	cerebral,cortex
R7428	T31881	T31870	punct	", ",areas
R7429	T31882	T31870	acl	accompanied,areas
R7430	T31883	T31882	agent	by,accompanied
R7431	T31750	T31749	advmod	certainly,is
R7432	T31884	T31885	det	a,increase
R7433	T31885	T31883	pobj	increase,by
R7434	T31886	T31885	amod	mild,increase
R7435	T31887	T31885	prep	in,increase
R7436	T31751	T31749	acomp	possible,is
R7437	T31888	T31889	det	the,number
R7438	T31889	T31887	pobj	number,in
R7439	T31890	T31889	prep	of,number
R7440	T31752	T31753	mark	that,activated
R7441	T31891	T31890	pobj	astrocytes,of
R7442	T31753	T31749	ccomp	activated,is
R7443	T31892	T31891	prep	in,astrocytes
R7444	T31754	T31755	amod	compensatory,mechanisms
R7445	T31893	T31894	det	the,ganglia
R7446	T31894	T31892	pobj	ganglia,in
R7447	T31755	T31753	nsubjpass	mechanisms,activated
R7448	T31895	T31894	amod	basal,ganglia
R7449	T31896	T31854	punct	.,revealed
R7450	T31968	T31962	acomp	apparent,was
R7451	T31898	T31899	det	The,basis
R7452	T31899	T31900	nsubj	basis,is
R7453	T31901	T31899	prep	for,basis
R7454	T31969	T31962	prep	in,was
R7455	T31902	T31903	det	this,finding
R7456	T31903	T31901	pobj	finding,for
R7458	T31904	T31903	amod	interesting,finding
R7459	T31905	T31904	cc	but,interesting
R7460	T31906	T31907	advmod	relatively,nonspecific
R7461	T31971	T31973	nmod	1α,mice
R7462	T31907	T31904	conj	nonspecific,interesting
R7463	T31908	T31900	acomp	unknown,is
R7464	T31972	T31971	punct	-,1α
R7465	T31909	T31900	punct	.,is
R7466	T31911	T31912	nsubj	It,is
R7467	T31973	T31969	pobj	mice,in
R7468	T31913	T31912	acomp	possible,is
R7469	T31974	T31971	punct	−,1α
R7470	T31914	T31915	mark	that,plays
R7471	T31915	T31912	ccomp	plays,is
R7472	T31916	T31917	compound	PGC,1α
R7473	T31975	T31971	punct	/,1α
R7474	T31917	T31915	nsubj	1α,plays
R7475	T31918	T31917	punct	-,1α
R7476	T31919	T31920	det	an,role
R7477	T31976	T31971	punct	−,1α
R7478	T31920	T31915	dobj	role,plays
R7479	T31921	T31920	amod	important,role
R7480	T31922	T31920	prep	in,role
R7481	T31923	T31924	compound	lipid,metabolism
R7482	T31924	T31922	pobj	metabolism,in
R7483	T31977	T31962	prep	during,was
R7484	T31925	T31920	acl	related,role
R7485	T31926	T31925	prep	to,related
R7486	T31927	T31928	compound	membrane,synthesis
R7487	T31978	T31979	det	the,mo
R7488	T31928	T31926	pobj	synthesis,to
R7489	T31929	T31912	punct	.,is
R7490	T31979	T31977	pobj	mo,during
R7491	T31931	T31932	advmod	Alternatively,altered
R7492	T31980	T31979	amod	first,mo
R7493	T31933	T31932	punct	", ",altered
R7494	T31934	T31935	det	the,process
R7495	T31935	T31932	nsubjpass	process,altered
R7496	T31981	T31979	nummod	6,mo
R7497	T31936	T31935	amod	normal,process
R7498	T31937	T31935	prep	of,process
R7499	T31938	T31939	amod	cellular,debris
R7500	T31982	T31979	prep	of,mo
R7501	T31939	T31940	compound	debris,turnover
R7502	T31940	T31937	pobj	turnover,of
R7503	T31983	T31982	pobj	life,of
R7504	T31941	T31932	aux	could,altered
R7505	T31942	T31932	auxpass	be,altered
R7506	T31943	T31932	prep	due,altered
R7507	T31984	T31985	punct	(,found
R7508	T31944	T31943	pcomp	to,due
R7509	T31945	T31946	det	a,defect
R7510	T31985	T31962	parataxis	found,was
R7511	T31946	T31943	pobj	defect,due
R7512	T31947	T31946	prep	in,defect
R7513	T31948	T31949	det	the,energetics
R7514	T31986	T31987	det	no,differences
R7515	T31949	T31947	pobj	energetics,in
R7516	T31950	T31949	prep	of,energetics
R7517	T31951	T31952	det	the,component
R7518	T31987	T31985	nsubjpass	differences,found
R7519	T31952	T31950	pobj	component,of
R7520	T31953	T31952	amod	microglial,component
R7521	T31988	T31987	compound	group,differences
R7522	T31954	T31952	prep	of,component
R7523	T31955	T31956	det	the,system
R7524	T31956	T31954	pobj	system,of
R7525	T31989	T31985	auxpass	were,found
R7526	T31957	T31956	amod	central,system
R7527	T31990	T31985	prep	on,found
R7528	T31991	T31992	quantmod	five,six
R7529	T31958	T31956	amod	nervous,system
R7530	T31992	T31994	nummod	six,tests
R7531	T31959	T31932	punct	.,altered
R7532	T31961	T31962	mark	Although,was
R7533	T31962	T31966	advcl	was,showed
R7534	T31963	T31964	amod	overt,dysfunction
R7535	T31993	T31992	quantmod	of,six
R7536	T31964	T31962	nsubj	dysfunction,was
R7537	T31965	T31964	amod	neurologic,dysfunction
R7538	T31994	T31990	pobj	tests,on
R7539	T31967	T31962	neg	not,was
R7540	T31995	T31994	compound	sensorimotor,tests
R7541	T31996	T31985	punct	),found
R7542	T31997	T31966	punct	", ",showed
R7543	T31998	T31999	det	the,mice
R7544	T32074	T32072	prep	in,function
R7545	T31999	T31966	nsubj	mice,showed
R7546	T32075	T32076	nmod	PGC,1α
R7547	T32076	T32078	nmod	1α,mice
R7548	T32000	T32001	nmod	PGC,1α
R7549	T32077	T32076	punct	-,1α
R7550	T32078	T32074	pobj	mice,in
R7551	T32001	T31999	nmod	1α,mice
R7552	T32079	T32076	punct	−,1α
R7553	T32080	T32076	punct	/,1α
R7554	T32081	T32076	punct	−,1α
R7555	T32002	T32001	punct	-,1α
R7556	T32082	T32053	punct	.,suggests
R7557	T32084	T32085	nsubj	It,be
R7558	T32003	T32001	punct	−,1α
R7559	T32086	T32085	aux	will,be
R7560	T32004	T32001	punct	/,1α
R7561	T32087	T32085	prep	of,be
R7562	T32088	T32087	pobj	interest,of
R7563	T32089	T32090	aux	to,determine
R7564	T32005	T32001	punct	−,1α
R7565	T32090	T32085	xcomp	determine,be
R7566	T32091	T32092	mark	whether,contribute
R7567	T32006	T32007	amod	clear,deficits
R7568	T32092	T32090	ccomp	contribute,determine
R7569	T32093	T32094	det	the,abnormalities
R7570	T32094	T32092	nsubj	abnormalities,contribute
R7571	T32007	T31966	dobj	deficits,showed
R7572	T32095	T32094	amod	neurologic,abnormalities
R7573	T32096	T32092	prep	to,contribute
R7574	T32097	T32098	det	the,abnormalities
R7575	T32008	T31966	prep	on,showed
R7576	T32098	T32096	pobj	abnormalities,to
R7577	T32099	T32098	amod	systemic,abnormalities
R7578	T32100	T32098	amod	metabolic,abnormalities
R7579	T32009	T32010	det	the,test
R7580	T32101	T32098	prep	of,abnormalities
R7581	T32102	T32103	det	the,mice
R7582	T32103	T32101	pobj	mice,of
R7583	T32104	T32105	compound	PGC,1α
R7584	T32105	T32107	npadvmod	1α,null
R7586	T32010	T32008	pobj	test,on
R7588	T32108	T32085	punct	.,be
R7589	T32110	T32111	prep	During,reported
R7590	T32011	T32010	amod	inverted,test
R7592	T32012	T32010	compound	screen,test
R7593	T32113	T32110	pobj	preparation,During
R7594	T32114	T32113	prep	of,preparation
R7595	T32115	T32116	det	this,manuscript
R7596	T32013	T31966	punct	.,showed
R7597	T32116	T32114	pobj	manuscript,of
R7598	T32117	T32111	punct	", ",reported
R7599	T32015	T32016	det	These,deficits
R7600	T32118	T32111	nsubj	Lin,reported
R7601	T32119	T32120	advmod	et,al.
R7602	T32120	T32118	advmod	al.,Lin
R7603	T32121	T32122	det	an,line
R7604	T32122	T32111	dobj	line,reported
R7605	T32016	T32017	nsubj	deficits,are
R7606	T32123	T32122	amod	independent,line
R7607	T32124	T32122	compound	mouse,line
R7608	T32125	T32126	prep	in,targeted
R7609	T32018	T32017	advmod	likely,are
R7610	T32126	T32122	relcl	targeted,line
R7611	T32127	T32125	pobj	which,in
R7612	T32128	T32129	det	the,gene
R7613	T32019	T32017	prep	due,are
R7614	T32129	T32126	nsubjpass	gene,targeted
R7615	T32130	T32131	compound	PGC,1α
R7616	T32131	T32129	compound	1α,gene
R7617	T32020	T32019	pcomp	to,due
R7618	T32132	T32131	punct	-,1α
R7619	T32133	T32126	auxpass	was,targeted
R7620	T32134	T32135	punct	[,37
R7621	T32021	T32022	amod	impaired,strength
R7622	T32135	T32111	parataxis	37,reported
R7623	T32136	T32135	punct	],37
R7624	T32022	T32019	pobj	strength,due
R7625	T32137	T32111	punct	.,reported
R7626	T32139	T32140	amod	Phenotypic,comparison
R7627	T32023	T32022	compound	muscle,strength
R7628	T32140	T32141	nsubj	comparison,reveals
R7629	T32024	T32022	prep	in,strength
R7630	T32142	T32140	prep	of,comparison
R7631	T32143	T32142	pcomp	the,of
R7632	T32144	T32145	poss	our,line
R7633	T32025	T32026	det	the,mice
R7634	T32145	T32142	pobj	line,of
R7635	T32146	T32147	compound	PGC,1α
R7636	T32147	T32149	npadvmod	1α,deficient
R7637	T32148	T32147	punct	-,1α
R7638	T32149	T32145	amod	deficient,line
R7639	T32150	T32149	punct	-,deficient
R7640	T32026	T32024	pobj	mice,in
R7641	T32151	T32140	prep	with,comparison
R7642	T32027	T32028	nmod	PGC,1α
R7643	T32152	T32151	pobj	that,with
R7644	T32028	T32026	nmod	1α,mice
R7645	T32153	T32152	prep	of,that
R7646	T32154	T32153	pobj	Lin,of
R7647	T32155	T32156	advmod	et,al.
R7648	T32029	T32028	punct	-,1α
R7649	T32156	T32154	advmod	al.,Lin
R7650	T32157	T32158	det	a,number
R7651	T32158	T32141	dobj	number,reveals
R7652	T32030	T32028	punct	−,1α
R7653	T32159	T32158	prep	of,number
R7654	T32160	T32159	pobj	similarities,of
R7655	T32161	T32158	cc	and,number
R7656	T32031	T32028	punct	/,1α
R7657	T32162	T32163	amod	several,differences
R7658	T32163	T32158	conj	differences,number
R7659	T32164	T32163	amod	interesting,differences
R7660	T32032	T32028	punct	−,1α
R7661	T32165	T32141	punct	.,reveals
R7662	T32033	T32017	punct	", ",are
R7663	T32167	T32168	det	Both,lines
R7664	T32168	T32174	nsubj	lines,exhibit
R7665	T32169	T32170	compound	PGC,1α
R7666	T32170	T32172	npadvmod	1α,deficient
R7667	T32034	T32017	cc	but,are
R7668	T32171	T32170	punct	-,1α
R7669	T32172	T32168	amod	deficient,lines
R7670	T32035	T32036	nsubj	contributions,be
R7671	T32173	T32172	punct	-,deficient
R7672	T32175	T32176	compound	cold,intolerance
R7673	T32036	T32017	conj	be,are
R7674	T32176	T32174	dobj	intolerance,exhibit
R7675	T32177	T32176	punct	", ",intolerance
R7676	T32178	T32179	amod	reduced,rates
R7677	T32037	T32035	prep	by,contributions
R7678	T32038	T32039	amod	peripheral,system
R7679	T32039	T32043	compound	system,determinants
R7680	T32040	T32038	cc	or,peripheral
R7681	T32179	T32176	conj	rates,intolerance
R7682	T32180	T32179	compound	hepatocyte,rates
R7683	T32181	T32179	compound	respiration,rates
R7684	T32041	T32038	conj	central,peripheral
R7685	T32182	T32179	punct	", ",rates
R7686	T32183	T32179	cc	and,rates
R7687	T32184	T32185	amod	neurologic,lesions
R7688	T32185	T32179	conj	lesions,rates
R7689	T32186	T32174	punct	.,exhibit
R7690	T32042	T32039	amod	nervous,system
R7691	T32188	T32189	advmod	However,are
R7692	T32043	T32037	pobj	determinants,by
R7693	T32190	T32189	punct	", ",are
R7694	T32191	T32192	det	a,number
R7695	T32044	T32043	punct	(,determinants
R7696	T32192	T32189	nsubj	number,are
R7697	T32193	T32192	prep	of,number
R7698	T32045	T32043	cc	or,determinants
R7699	T32194	T32195	amod	interesting,differences
R7700	T32195	T32193	pobj	differences,of
R7701	T32196	T32189	acomp	notable,are
R7702	T32046	T32043	conj	both,determinants
R7703	T32197	T32189	punct	.,are
R7704	T32047	T32036	punct	),be
R7705	T32199	T32200	advmod	First,exhibit
R7706	T32201	T32200	punct	", ",exhibit
R7707	T32048	T32036	aux	could,be
R7708	T32202	T32200	prep	in,exhibit
R7709	T32203	T32202	pobj	contrast,in
R7710	T32049	T32036	acomp	contributory,be
R7711	T32204	T32203	prep	to,contrast
R7712	T32205	T32204	pobj	Lin,to
R7713	T32050	T32036	punct	.,be
R7714	T32206	T32207	advmod	et,al.
R7715	T32207	T32205	advmod	al.,Lin
R7716	T32208	T32200	punct	", ",exhibit
R7717	T32052	T32053	advmod	Moreover,suggests
R7718	T32209	T32210	det	the,mice
R7719	T32210	T32200	nsubj	mice,exhibit
R7720	T32211	T32212	nmod	PGC,1α
R7721	T32054	T32053	punct	", ",suggests
R7722	T32212	T32210	nmod	1α,mice
R7723	T32213	T32212	punct	-,1α
R7724	T32214	T32212	punct	−,1α
R7725	T32215	T32212	punct	/,1α
R7726	T32216	T32212	punct	−,1α
R7727	T32055	T32053	nsubj	evidence,suggests
R7728	T32217	T32210	acl	described,mice
R7729	T32218	T32217	advmod	here,described
R7730	T32056	T32055	prep	of,evidence
R7731	T32219	T32200	aux	do,exhibit
R7732	T32220	T32200	neg	not,exhibit
R7733	T32221	T32222	det	any,mortality
R7734	T32057	T32058	amod	altered,emotionality
R7735	T32222	T32200	dobj	mortality,exhibit
R7736	T32223	T32222	amod	postnatal,mortality
R7737	T32224	T32200	punct	.,exhibit
R7738	T32226	T32227	advmod	Second,find
R7739	T32058	T32056	pobj	emotionality,of
R7740	T32228	T32227	punct	", ",find
R7741	T32229	T32227	nsubj	we,find
R7742	T32230	T32227	aux	did,find
R7743	T32059	T32058	prep	from,emotionality
R7744	T32231	T32227	neg	not,find
R7745	T32232	T32227	dobj	evidence,find
R7746	T32060	T32061	det	the,test
R7747	T32233	T32232	prep	for,evidence
R7748	T32234	T32235	det	a,defect
R7749	T32235	T32233	pobj	defect,for
R7750	T32236	T32235	prep	in,defect
R7751	T32061	T32059	pobj	test,from
R7752	T32237	T32236	pobj	gluconeogenesis,in
R7753	T32238	T32232	prep	based,evidence
R7754	T32239	T32238	prep	on,based
R7755	T32062	T32063	nummod	1,h
R7756	T32063	T32061	compound	h,test
R7757	T32240	T32241	compound	fasting,levels
R7758	T32064	T32063	punct	-,h
R7759	T32241	T32239	pobj	levels,on
R7760	T32242	T32243	compound	blood,glucose
R7761	T32243	T32241	compound	glucose,levels
R7762	T32065	T32061	compound	locomotor,test
R7763	T32244	T32245	punct	(,data
R7764	T32245	T32227	meta	data,find
R7765	T32246	T32245	amod	unpublished,data
R7766	T32066	T32061	compound	activity,test
R7767	T32247	T32245	punct	),data
R7768	T32248	T32227	punct	.,find
R7769	T32067	T32053	advmod	also,suggests
R7770	T32250	T32251	prep	In,did
R7771	T32068	T32069	det	the,possibility
R7772	T32252	T32250	pobj	addition,In
R7773	T32253	T32251	punct	", ",did
R7774	T32254	T32255	mark	whereas,found
R7775	T32069	T32053	dobj	possibility,suggests
R7776	T32255	T32251	advcl	found,did
R7777	T32256	T32255	nsubj	Lin,found
R7778	T32070	T32069	prep	of,possibility
R7779	T32257	T32258	advmod	et,al.
R7780	T32258	T32256	advmod	al.,Lin
R7781	T32259	T32260	det	an,profile
R7782	T32071	T32072	amod	altered,function
R7783	T32260	T32255	dobj	profile,found
R7784	T32261	T32260	amod	abnormal,profile
R7785	T32072	T32070	pobj	function,of
R7786	T32262	T32260	compound	expression,profile
R7787	T32263	T32260	prep	for,profile
R7788	T32264	T32265	compound	CCAAT,enhancer
R7789	T32073	T32072	compound	brain,function
R7790	T32265	T32267	npadvmod	enhancer,binding
R7791	T32266	T32265	punct	-,enhancer
R7792	T32267	T32269	amod	binding,β
R7793	T32268	T32267	punct	-,binding
R7794	T32269	T32263	pobj	β,for
R7795	T32270	T32269	compound	protein,β
R7796	T32285	T32282	punct	-,phosphatase
R7797	T32271	T32269	cc	and,β
R7798	T32272	T32269	conj	δ,β
R7799	T32273	T32269	cc	and,β
R7800	T32274	T32275	det	the,genes
R7801	T32275	T32269	conj	genes,β
R7802	T32276	T32275	amod	gluconeogenic,genes
R7803	T32286	T32255	prep	at,found
R7804	T32277	T32275	acl	encoding,genes
R7805	T32278	T32279	compound	phosphoenolpyruvate,carboxykinase
R7806	T32287	T32286	pobj	baseline,at
R7807	T32279	T32277	dobj	carboxykinase,encoding
R7808	T32280	T32279	cc	and,carboxykinase
R7809	T32281	T32282	nmod	glucose,phosphatase
R7810	T32288	T32286	cc	and,at
R7811	T32282	T32279	conj	phosphatase,carboxykinase
R7812	T32283	T32282	punct	-,phosphatase
R7813	T32289	T32286	conj	with,at
R7814	T32284	T32282	nummod	6,phosphatase
R7815	T32290	T32289	pobj	fasting,with
R7816	T32291	T32255	prep	in,found
R7817	T32292	T32293	det	the,mice
R7818	T32293	T32291	pobj	mice,in
R7819	T32390	T32391	det	the,phenotype
R7820	T32294	T32295	nmod	PGC,1α
R7821	T32391	T32389	nsubj	phenotype,occurred
R7822	T32392	T32393	npadvmod	insulin,sensitive
R7823	T32295	T32293	nmod	1α,mice
R7824	T32393	T32391	amod	sensitive,phenotype
R7825	T32394	T32393	punct	-,sensitive
R7826	T32296	T32295	punct	-,1α
R7827	T32395	T32391	prep	of,phenotype
R7828	T32396	T32397	det	the,mice
R7829	T32397	T32395	pobj	mice,of
R7830	T32297	T32295	punct	−,1α
R7831	T32398	T32397	amod	female,mice
R7832	T32399	T32400	nmod	PGC,1α
R7833	T32298	T32295	punct	/,1α
R7834	T32400	T32397	nmod	1α,mice
R7835	T32401	T32400	punct	-,1α
R7836	T32402	T32400	punct	−,1α
R7837	T32299	T32295	punct	−,1α
R7838	T32403	T32400	punct	/,1α
R7839	T32404	T32400	punct	−,1α
R7840	T32300	T32251	punct	", ",did
R7841	T32405	T32389	prep	in,occurred
R7842	T32406	T32407	det	the,context
R7843	T32407	T32405	pobj	context,in
R7844	T32408	T32407	prep	of,context
R7845	T32301	T32251	nsubj	we,did
R7846	T32409	T32410	amod	normal,gain
R7847	T32410	T32408	pobj	gain,of
R7848	T32302	T32251	neg	not,did
R7849	T32411	T32410	compound	weight,gain
R7850	T32412	T32410	prep	with,gain
R7851	T32413	T32414	amod	high,fat
R7852	T32303	T32304	punct	(,data
R7853	T32414	T32416	compound	fat,diet
R7854	T32415	T32414	punct	-,fat
R7855	T32416	T32412	pobj	diet,with
R7856	T32304	T32251	meta	data,did
R7857	T32417	T32385	punct	.,observed
R7858	T32305	T32304	amod	unpublished,data
R7859	T32419	T32420	det	These,results
R7860	T32420	T32422	nsubj	results,indicate
R7861	T32306	T32304	punct	),data
R7862	T32421	T32420	amod	latter,results
R7863	T32423	T32424	mark	that,explained
R7864	T32307	T32251	punct	.,did
R7865	T32424	T32422	ccomp	explained,indicate
R7866	T32425	T32426	det	the,phenotype
R7867	T32309	T32310	advmod	Third,found
R7868	T32426	T32424	nsubjpass	phenotype,explained
R7869	T32427	T32428	npadvmod	insulin,sensitive
R7870	T32428	T32426	amod	sensitive,phenotype
R7871	T32429	T32428	punct	-,sensitive
R7872	T32311	T32310	punct	", ",found
R7873	T32430	T32426	prep	of,phenotype
R7874	T32431	T32432	nmod	PGC,1α
R7875	T32432	T32434	nmod	1α,mice
R7876	T32312	T32310	nsubj	we,found
R7877	T32433	T32432	punct	-,1α
R7878	T32434	T32430	pobj	mice,of
R7879	T32435	T32432	punct	−,1α
R7880	T32313	T32310	dobj	evidence,found
R7881	T32436	T32432	punct	/,1α
R7882	T32437	T32432	punct	−,1α
R7883	T32314	T32313	prep	for,evidence
R7884	T32438	T32424	aux	can,explained
R7885	T32439	T32424	neg	not,explained
R7886	T32440	T32424	auxpass	be,explained
R7887	T32315	T32316	det	an,increase
R7888	T32441	T32424	advmod	fully,explained
R7889	T32442	T32424	agent	by,explained
R7890	T32443	T32444	det	a,phenotype
R7891	T32316	T32314	pobj	increase,for
R7892	T32444	T32442	pobj	phenotype,by
R7893	T32445	T32444	amod	lean,phenotype
R7894	T32446	T32422	punct	.,indicate
R7895	T32448	T32449	prep	Of,exhibit
R7896	T32317	T32318	npadvmod	age,related
R7897	T32450	T32448	pobj	interest,Of
R7898	T32451	T32449	punct	", ",exhibit
R7899	T32318	T32316	amod	related,increase
R7900	T32452	T32449	nsubj	mice,exhibit
R7901	T32453	T32452	acl	lacking,mice
R7902	T32454	T32455	det	the,receptor
R7903	T32319	T32318	punct	-,related
R7904	T32455	T32453	dobj	receptor,lacking
R7905	T32456	T32455	amod	nuclear,receptor
R7906	T32320	T32316	prep	in,increase
R7907	T32457	T32458	npadvmod	estrogen,related
R7908	T32458	T32460	amod	related,α
R7909	T32459	T32458	punct	-,related
R7910	T32321	T32322	compound	body,fat
R7911	T32460	T32455	appos	α,receptor
R7912	T32461	T32460	compound	receptor,α
R7913	T32322	T32320	pobj	fat,in
R7914	T32462	T32455	punct	", ",receptor
R7915	T32463	T32464	det	a,target
R7916	T32464	T32455	appos	target,receptor
R7917	T32323	T32322	prep	in,fat
R7918	T32465	T32464	amod	known,target
R7919	T32466	T32464	prep	of,target
R7920	T32467	T32468	compound	PGC,1α
R7921	T32324	T32325	nmod	PGC,1α
R7922	T32468	T32466	pobj	1α,of
R7923	T32469	T32468	punct	-,1α
R7924	T32470	T32449	punct	", ",exhibit
R7925	T32325	T32327	nmod	1α,mice
R7926	T32471	T32449	dobj	resistance,exhibit
R7927	T32472	T32471	prep	to,resistance
R7928	T32326	T32325	punct	-,1α
R7929	T32473	T32474	npadvmod	diet,induced
R7930	T32474	T32476	amod	induced,obesity
R7932	T32327	T32323	pobj	mice,in
R7935	T32328	T32325	punct	−,1α
R7936	T32478	T32477	prep	to,similar
R7937	T32479	T32478	pobj	that,to
R7938	T32480	T32479	prep	of,that
R7939	T32329	T32325	punct	/,1α
R7940	T32481	T32482	amod	male,mice
R7941	T32482	T32480	pobj	mice,of
R7942	T32330	T32325	punct	−,1α
R7943	T32483	T32484	compound	PGC,1α
R7944	T32484	T32486	npadvmod	1α,null
R7945	T32485	T32484	punct	-,1α
R7946	T32486	T32482	amod	null,mice
R7947	T32487	T32488	punct	[,38
R7948	T32331	T32332	punct	(,females
R7949	T32488	T32449	parataxis	38,exhibit
R7950	T32489	T32488	punct	],38
R7951	T32490	T32449	punct	.,exhibit
R7952	T32332	T32316	parataxis	females,increase
R7953	T32492	T32493	advmod	Fourth,exhibit
R7954	T32333	T32332	advmod	earlier,females
R7955	T32494	T32493	punct	", ",exhibit
R7956	T32334	T32333	prep	than,earlier
R7957	T32335	T32334	pobj	males,than
R7958	T32336	T32332	punct	),females
R7959	T32495	T32496	det	the,mice
R7960	T32496	T32493	nsubj	mice,exhibit
R7961	T32337	T32310	punct	", ",found
R7962	T32497	T32498	nmod	PGC,1α
R7963	T32498	T32496	nmod	1α,mice
R7964	T32338	T32339	mark	whereas,identified
R7965	T32499	T32498	punct	-,1α
R7966	T32500	T32498	punct	−,1α
R7967	T32501	T32498	punct	/,1α
R7968	T32339	T32310	advcl	identified,found
R7969	T32502	T32498	punct	−,1α
R7970	T32503	T32496	acl	described,mice
R7971	T32340	T32339	nsubj	Lin,identified
R7972	T32504	T32503	advmod	here,described
R7973	T32505	T32506	det	a,phenotype
R7974	T32341	T32342	advmod	et,al.
R7975	T32506	T32493	dobj	phenotype,exhibit
R7976	T32507	T32506	amod	dramatic,phenotype
R7977	T32508	T32509	npadvmod	fasting,induced
R7978	T32342	T32340	advmod	al.,Lin
R7979	T32509	T32506	amod	induced,phenotype
R7980	T32510	T32509	punct	-,induced
R7981	T32511	T32506	amod	hepatic,phenotype
R7982	T32343	T32344	det	a,resistance
R7983	T32512	T32506	amod	steatotic,phenotype
R7984	T32513	T32493	punct	", ",exhibit
R7985	T32344	T32339	dobj	resistance,identified
R7986	T32514	T32515	mark	whereas,does
R7987	T32515	T32493	advcl	does,exhibit
R7988	T32516	T32517	det	the,mouse
R7989	T32345	T32346	npadvmod	male,specific
R7990	T32517	T32515	nsubj	mouse,does
R7991	T32518	T32517	nmod	Lin,mouse
R7992	T32346	T32344	amod	specific,resistance
R7993	T32519	T32520	advmod	et,al.
R7994	T32520	T32518	advmod	al.,Lin
R7995	T32521	T32515	neg	not,does
R7996	T32347	T32346	punct	-,specific
R7997	T32522	T32493	punct	.,exhibit
R7998	T32524	T32525	advmod	Fifth,found
R7999	T32526	T32525	punct	", ",found
R8000	T32348	T32344	prep	to,resistance
R8001	T32527	T32525	nsubj	Lin,found
R8002	T32528	T32529	advmod	et,al.
R8003	T32529	T32527	advmod	al.,Lin
R8004	T32530	T32531	det	a,phenotype
R8005	T32349	T32350	npadvmod	diet,induced
R8006	T32531	T32525	dobj	phenotype,found
R8007	T32532	T32531	amod	neurologic,phenotype
R8008	T32533	T32531	prep	in,phenotype
R8009	T32350	T32352	amod	induced,obesity
R8010	T32534	T32533	pobj	males,in
R8011	T32535	T32531	acl	characterized,phenotype
R8012	T32351	T32350	punct	-,induced
R8013	T32536	T32535	agent	by,characterized
R8014	T32537	T32536	pobj	hyperactivity,by
R8015	T32538	T32525	punct	", ",found
R8016	T32352	T32348	pobj	obesity,to
R8017	T32539	T32540	mark	whereas,show
R8018	T32540	T32525	advcl	show,found
R8019	T32541	T32542	det	the,mice
R8020	T32353	T32352	cc	and,obesity
R8021	T32542	T32540	nsubj	mice,show
R8022	T32543	T32544	nmod	PGC,1α
R8023	T32354	T32355	compound	insulin,resistance
R8024	T32544	T32542	nmod	1α,mice
R8025	T32545	T32544	punct	-,1α
R8026	T32546	T32544	punct	−,1α
R8027	T32355	T32352	conj	resistance,obesity
R8028	T32547	T32544	punct	/,1α
R8029	T32548	T32544	punct	−,1α
R8030	T32549	T32542	acl	described,mice
R8031	T32356	T32310	punct	.,found
R8032	T32550	T32549	advmod	here,described
R8033	T32551	T32552	amod	reduced,activity
R8034	T32552	T32540	dobj	activity,show
R8035	T32358	T32359	nsubj	We,found
R8036	T32553	T32552	compound	locomotor,activity
R8037	T32554	T32525	punct	.,found
R8038	T32360	T32359	aux	have,found
R8039	T32556	T32557	advmod	However,noted
R8040	T32557	T32562	ccomp	noted,is
R8041	T32558	T32557	punct	", ",noted
R8042	T32559	T32557	nsubjpass	it,noted
R8043	T32560	T32557	aux	should,noted
R8044	T32361	T32359	advmod	also,found
R8045	T32561	T32557	auxpass	be,noted
R8046	T32362	T32363	mark	that,protected
R8047	T32563	T32564	mark	that,study
R8048	T32564	T32557	ccomp	study,noted
R8049	T32565	T32564	nsubj	we,study
R8050	T32566	T32564	aux	did,study
R8051	T32567	T32564	neg	not,study
R8052	T32363	T32359	ccomp	protected,found
R8053	T32568	T32569	compound	activity,levels
R8054	T32569	T32564	dobj	levels,study
R8055	T32570	T32564	prep	over,study
R8056	T32364	T32365	amod	male,mice
R8057	T32571	T32572	det	an,period
R8058	T32572	T32570	pobj	period,over
R8059	T32573	T32572	amod	extended,period
R8060	T32365	T32363	nsubjpass	mice,protected
R8061	T32574	T32572	prep	of,period
R8062	T32575	T32574	pobj	time,of
R8063	T32576	T32564	prep	in,study
R8064	T32366	T32367	compound	PGC,1α
R8065	T32577	T32576	pobj	males,in
R8066	T32578	T32579	mark	as,did
R8067	T32367	T32369	npadvmod	1α,deficient
R8068	T32579	T32564	advcl	did,study
R8069	T32368	T32367	punct	-,1α
R8070	T32580	T32579	nsubj	Lin,did
R8071	T32581	T32582	advmod	et,al.
R8072	T32369	T32365	amod	deficient,mice
R8073	T32582	T32580	advmod	al.,Lin
R8074	T32583	T32562	punct	", ",is
R8075	T32584	T32562	advmod	so,is
R8076	T32370	T32369	punct	-,deficient
R8077	T32585	T32562	nsubj	it,is
R8078	T32586	T32562	acomp	possible,is
R8079	T32371	T32363	auxpass	are,protected
R8080	T32587	T32588	mark	that,reflect
R8081	T32588	T32562	ccomp	reflect,is
R8082	T32589	T32590	poss	our,findings
R8083	T32372	T32363	advmod	somewhat,protected
R8084	T32590	T32588	nsubj	findings,reflect
R8085	T32591	T32592	det	an,disturbance
R8086	T32373	T32363	prep	against,protected
R8087	T32592	T32588	dobj	disturbance,reflect
R8088	T32593	T32592	amod	emotional,disturbance
R8089	T32594	T32595	dep	that,manifests
R8090	T32374	T32375	npadvmod	diet,induced
R8091	T32595	T32592	relcl	manifests,disturbance
R8092	T32596	T32597	advmod	only,placed
R8093	T32597	T32595	advcl	placed,manifests
R8094	T32375	T32377	amod	induced,obesity
R8095	T32598	T32597	advmod	when,placed
R8096	T32599	T32600	det	the,animals
R8097	T32600	T32597	nsubjpass	animals,placed
R8098	T32376	T32375	punct	-,induced
R8099	T32377	T32373	pobj	obesity,against
R8100	T32378	T32379	punct	(,S4
R8101	T32379	T32359	parataxis	S4,found
R8102	T32601	T32597	auxpass	are,placed
R8103	T32602	T32597	prep	in,placed
R8104	T32603	T32604	det	a,environment
R8105	T32604	T32602	pobj	environment,in
R8106	T32380	T32379	compound	Figure,S4
R8107	T32605	T32604	amod	new,environment
R8108	T32606	T32562	punct	.,is
R8109	T32381	T32379	punct	),S4
R8110	T32608	T32609	advmod	Finally,report
R8111	T32610	T32609	punct	", ",report
R8112	T32382	T32359	punct	.,found
R8113	T32611	T32609	nsubj	we,report
R8114	T32612	T32613	amod	significant,abnormalities
R8115	T32384	T32385	advmod	However,observed
R8116	T32613	T32609	dobj	abnormalities,report
R8117	T32614	T32615	amod	skeletal,muscle
R8118	T32615	T32613	nmod	muscle,abnormalities
R8119	T32386	T32385	punct	", ",observed
R8120	T32616	T32615	cc	and,muscle
R8121	T32617	T32618	amod	cardiac,functional
R8122	T32618	T32615	conj	functional,muscle
R8123	T32619	T32609	punct	(,report
R8124	T32387	T32385	nsubj	we,observed
R8125	T32620	T32621	mark	although,represent
R8126	T32621	T32609	advcl	represent,report
R8127	T32622	T32623	det	the,report
R8128	T32388	T32389	mark	that,occurred
R8129	T32623	T32624	nsubj	report,address
R8130	T32624	T32621	ccomp	address,represent
R8131	T32389	T32385	ccomp	occurred,observed
R8132	T32625	T32623	prep	by,report
R8133	T32626	T32625	pobj	Lin,by
R8134	T32707	T32708	advmod	et,al.
R8135	T32627	T32628	advmod	et,al.
R8136	T32628	T32626	advmod	al.,Lin
R8137	T32629	T32624	aux	did,address
R8138	T32630	T32624	neg	not,address
R8139	T32631	T32632	det	these,phenotypes
R8140	T32708	T32706	advmod	al.,Lin
R8141	T32632	T32624	dobj	phenotypes,address
R8142	T32633	T32621	punct	", ",represent
R8143	T32634	T32621	advmod	so,represent
R8144	T32635	T32621	nsubj	this,represent
R8145	T32709	T32686	aux	could,resulted
R8146	T32636	T32621	aux	may,represent
R8147	T32637	T32621	neg	not,represent
R8148	T32638	T32639	det	a,difference
R8149	T32710	T32686	aux	have,resulted
R8150	T32639	T32621	dobj	difference,represent
R8151	T32640	T32639	amod	true,difference
R8152	T32711	T32686	prep	in,resulted
R8153	T32641	T32609	punct	),report
R8154	T32642	T32609	punct	.,report
R8155	T32644	T32645	det	The,reasons
R8156	T32645	T32646	nsubj	reasons,are
R8157	T32712	T32713	det	a,bias
R8158	T32647	T32645	prep	for,reasons
R8159	T32648	T32649	det	the,differences
R8160	T32713	T32711	pobj	bias,in
R8161	T32649	T32647	pobj	differences,for
R8162	T32650	T32649	amod	interesting,differences
R8163	T32651	T32649	prep	between,differences
R8164	T32714	T32713	compound	selection,bias
R8165	T32652	T32653	det	the,lines
R8166	T32653	T32651	pobj	lines,between
R8167	T32654	T32653	nummod	two,lines
R8168	T32715	T32713	prep	toward,bias
R8169	T32655	T32656	compound	PGC,1α
R8170	T32656	T32658	npadvmod	1α,deficient
R8171	T32716	T32717	amod	greater,levels
R8172	T32657	T32656	punct	-,1α
R8173	T32658	T32653	amod	deficient,lines
R8174	T32659	T32658	punct	-,deficient
R8175	T32717	T32715	pobj	levels,toward
R8176	T32660	T32653	compound	mouse,lines
R8177	T32661	T32646	neg	not,are
R8178	T32662	T32646	acomp	clear,are
R8179	T32718	T32717	prep	of,levels
R8180	T32719	T32720	amod	compensatory,responses
R8181	T32663	T32646	punct	.,are
R8182	T32720	T32718	pobj	responses,of
R8183	T32665	T32666	nsubj	It,is
R8184	T32721	T32720	prep	in,responses
R8185	T32667	T32666	acomp	possible,is
R8186	T32668	T32669	mark	that,confer
R8187	T32722	T32721	pobj	liver,in
R8188	T32669	T32666	ccomp	confer,is
R8189	T32670	T32671	amod	distinct,backgrounds
R8190	T32723	T32722	cc	and,liver
R8191	T32671	T32669	nsubj	backgrounds,confer
R8192	T32672	T32671	amod	genetic,backgrounds
R8193	T32724	T32725	amod	other,tissues
R8194	T32673	T32671	acl	related,backgrounds
R8195	T32674	T32673	prep	to,related
R8196	T32675	T32676	compound	hybrid,strains
R8197	T32676	T32674	pobj	strains,to
R8198	T32725	T32722	conj	tissues,liver
R8199	T32677	T32678	amod	different,degrees
R8200	T32678	T32669	dobj	degrees,confer
R8201	T32726	T32686	prep	in,resulted
R8202	T32679	T32678	prep	of,degrees
R8203	T32680	T32681	amod	secondary,responses
R8204	T32681	T32679	pobj	responses,of
R8205	T32727	T32728	det	the,group
R8206	T32682	T32681	amod	compensatory,responses
R8207	T32683	T32666	punct	.,is
R8208	T32685	T32686	prep	In,resulted
R8209	T32687	T32685	pobj	addition,In
R8210	T32728	T32726	pobj	group,in
R8211	T32688	T32686	punct	", ",resulted
R8212	T32689	T32690	det	the,mortality
R8213	T32690	T32686	nsubj	mortality,resulted
R8214	T32729	T32728	amod	surviving,group
R8215	T32691	T32692	advmod	incompletely,penetrant
R8216	T32692	T32690	amod	penetrant,mortality
R8217	T32693	T32690	amod	postnatal,mortality
R8218	T32730	T32686	punct	.,resulted
R8219	T32694	T32690	acl	noted,mortality
R8220	T32695	T32694	prep	in,noted
R8221	T32696	T32697	det	the,mice
R8222	T32732	T32733	nsubj	It,is
R8223	T32697	T32695	pobj	mice,in
R8224	T32698	T32699	nmod	PGC,1α
R8225	T32699	T32697	nmod	1α,mice
R8226	T32734	T32733	advmod	also,is
R8227	T32700	T32699	punct	-,1α
R8228	T32701	T32699	punct	−,1α
R8229	T32702	T32699	punct	/,1α
R8230	T32703	T32699	punct	−,1α
R8231	T32735	T32733	acomp	possible,is
R8232	T32704	T32690	acl	reported,mortality
R8233	T32705	T32704	prep	by,reported
R8234	T32706	T32705	pobj	Lin,by
R8235	T32736	T32737	mark	that,led
R8236	T32737	T32733	ccomp	led,is
R8237	T32738	T32739	det	the,method
R8238	T32739	T32737	nsubj	method,led
R8239	T32740	T32739	prep	of,method
R8240	T32813	T32812	cc	and,5
R8241	T32741	T32742	compound	gene,targeting
R8242	T32814	T32812	conj	6,5
R8243	T32815	T32782	punct	.,generated
R8244	T32742	T32740	pobj	targeting,of
R8245	T32817	T32818	det	The,insertion
R8246	T32743	T32737	prep	to,led
R8247	T32818	T32821	nsubj	insertion,results
R8248	T32819	T32818	nmod	exon,insertion
R8249	T32820	T32819	nummod	3,exon
R8250	T32744	T32745	amod	different,phenotypes
R8251	T32822	T32818	punct	", ",insertion
R8252	T32823	T32824	dep	which,confirmed
R8253	T32745	T32743	pobj	phenotypes,to
R8254	T32824	T32818	relcl	confirmed,insertion
R8255	T32825	T32824	auxpass	was,confirmed
R8256	T32746	T32733	punct	.,is
R8257	T32826	T32824	prep	by,confirmed
R8258	T32827	T32828	compound	RT,PCR
R8259	T32828	T32826	pobj	PCR,by
R8260	T32829	T32828	punct	-,PCR
R8261	T32830	T32821	punct	", ",results
R8262	T32748	T32749	nsubj	Lin,generated
R8263	T32831	T32821	prep	in,results
R8264	T32832	T32833	det	a,transcript
R8265	T32833	T32831	pobj	transcript,in
R8266	T32834	T32833	compound	mutant,transcript
R8267	T32750	T32751	advmod	et,al.
R8268	T32835	T32836	dep	that,encodes
R8269	T32836	T32833	relcl	encodes,transcript
R8270	T32751	T32748	advmod	al.,Lin
R8271	T32837	T32838	det	a,protein
R8272	T32752	T32753	nmod	PGC,1α
R8273	T32838	T32836	dobj	protein,encodes
R8274	T32839	T32838	amod	truncated,protein
R8275	T32753	T32755	nmod	1α,mice
R8276	T32840	T32821	punct	.,results
R8277	T32842	T32843	nsubj	We,were
R8278	T32754	T32753	punct	-,1α
R8279	T32844	T32843	acomp	unable,were
R8280	T32845	T32846	aux	to,detect
R8281	T32755	T32749	dobj	mice,generated
R8282	T32846	T32844	xcomp	detect,unable
R8283	T32847	T32848	amod	normal,transcript
R8284	T32756	T32753	punct	−,1α
R8285	T32848	T32846	dobj	transcript,detect
R8286	T32849	T32848	acl	containing,transcript
R8287	T32850	T32851	det	an,border
R8288	T32757	T32753	punct	/,1α
R8289	T32851	T32849	dobj	border,containing
R8290	T32852	T32853	nmod	exon,5
R8291	T32758	T32753	punct	−,1α
R8292	T32853	T32851	nummod	5,border
R8293	T32854	T32855	punct	–,6
R8294	T32855	T32853	prep	6,5
R8295	T32759	T32749	prep	by,generated
R8296	T32856	T32843	punct	", ",were
R8297	T32857	T32843	advcl	indicating,were
R8298	T32858	T32859	mark	that,was
R8299	T32760	T32761	compound	Cre,recombinase
R8300	T32859	T32857	ccomp	was,indicating
R8301	T32860	T32861	det	the,targeting
R8302	T32761	T32762	npadvmod	recombinase,mediated
R8303	T32861	T32859	nsubj	targeting,was
R8304	T32862	T32859	acomp	accurate,was
R8305	T32863	T32862	cc	and,accurate
R8306	T32762	T32764	amod	mediated,excision
R8307	T32864	T32862	conj	complete,accurate
R8308	T32865	T32843	punct	.,were
R8309	T32763	T32762	punct	-,mediated
R8310	T32867	T32868	prep	In,detect
R8311	T32869	T32867	pobj	addition,In
R8312	T32870	T32868	punct	", ",detect
R8313	T32871	T32868	nsubj	we,detect
R8314	T32764	T32759	pobj	excision,by
R8315	T32872	T32868	aux	could,detect
R8316	T32873	T32868	neg	not,detect
R8317	T32874	T32875	amod	full,length
R8318	T32765	T32764	prep	of,excision
R8319	T32875	T32877	nmod	length,proteins
R8320	T32876	T32875	punct	-,length
R8321	T32766	T32767	nmod	exons,3
R8322	T32877	T32868	dobj	proteins,detect
R8323	T32878	T32875	cc	or,length
R8324	T32879	T32875	conj	smaller,length
R8325	T32767	T32765	pobj	3,of
R8326	T32880	T32881	compound	PGC,1α
R8327	T32881	T32877	compound	1α,proteins
R8328	T32882	T32881	punct	-,1α
R8329	T32768	T32769	punct	–,5
R8330	T32883	T32868	prep	by,detect
R8331	T32884	T32885	compound	Western,blotting
R8332	T32885	T32883	pobj	blotting,by
R8333	T32769	T32767	prep	5,3
R8334	T32886	T32868	punct	.,detect
R8335	T32770	T32764	prep	in,excision
R8336	T32888	T32889	advmod	However,exclude
R8337	T32890	T32889	punct	", ",exclude
R8338	T32771	T32770	pobj	oocytes,in
R8339	T32891	T32889	nsubj	we,exclude
R8340	T32892	T32889	aux	can,exclude
R8341	T32893	T32889	neg	not,exclude
R8342	T32772	T32749	punct	.,generated
R8343	T32894	T32895	det	the,possibility
R8344	T32895	T32889	dobj	possibility,exclude
R8345	T32896	T32897	mark	that,was
R8346	T32774	T32775	det	The,mice
R8347	T32897	T32895	acl	was,possibility
R8348	T32898	T32899	det	the,sensitivity
R8349	T32899	T32897	nsubj	sensitivity,was
R8350	T32775	T32782	nsubjpass	mice,generated
R8351	T32900	T32899	prep	of,sensitivity
R8352	T32901	T32902	det	the,immunoblotting
R8353	T32902	T32900	pobj	immunoblotting,of
R8354	T32776	T32777	nmod	PGC,1α
R8355	T32903	T32897	neg	not,was
R8356	T32904	T32897	acomp	high,was
R8357	T32777	T32775	nmod	1α,mice
R8358	T32905	T32904	advmod	enough,high
R8359	T32906	T32907	aux	to,pick
R8360	T32907	T32904	xcomp	pick,high
R8361	T32778	T32777	punct	-,1α
R8362	T32908	T32907	prt	up,pick
R8363	T32909	T32910	det	a,amount
R8364	T32910	T32907	dobj	amount,pick
R8365	T32911	T32910	amod	small,amount
R8366	T32912	T32910	prep	of,amount
R8367	T32779	T32777	punct	−,1α
R8368	T32913	T32914	nmod	mutant,protein
R8369	T32914	T32912	pobj	protein,of
R8370	T32915	T32914	punct	(,protein
R8371	T32780	T32777	punct	/,1α
R8372	T32916	T32914	amod	truncated,protein
R8373	T32917	T32914	punct	),protein
R8374	T32918	T32919	compound	PGC,1α
R8375	T32781	T32777	punct	−,1α
R8376	T32783	T32775	acl	described,mice
R8377	T32784	T32783	advmod	here,described
R8378	T32919	T32914	compound	1α,protein
R8379	T32920	T32919	punct	-,1α
R8380	T32921	T32922	dep	that,have
R8381	T32785	T32782	auxpass	were,generated
R8382	T32786	T32782	agent	by,generated
R8383	T32922	T32910	relcl	have,amount
R8384	T32787	T32788	det	a,event
R8385	T32923	T32922	aux	could,have
R8386	T32924	T32925	det	some,activity
R8387	T32788	T32786	pobj	event,by
R8388	T32925	T32922	dobj	activity,have
R8389	T32926	T32922	punct	", ",have
R8390	T32789	T32788	compound	targeting,event
R8391	T32927	T32922	prep	given,have
R8392	T32928	T32929	mark	that,contain
R8393	T32929	T32927	pcomp	contain,given
R8394	T32790	T32791	dep	that,involved
R8395	T32930	T32929	nsubj	it,contain
R8396	T32931	T32929	aux	would,contain
R8397	T32932	T32933	amod	nuclear,receptor
R8398	T32791	T32788	relcl	involved,event
R8399	T32933	T32934	npadvmod	receptor,interacting
R8400	T32934	T32936	amod	interacting,domains
R8401	T32792	T32793	det	a,recombination
R8402	T32935	T32934	punct	-,interacting
R8403	T32936	T32929	dobj	domains,contain
R8404	T32937	T32936	cc	and,domains
R8405	T32793	T32791	dobj	recombination,involved
R8406	T32938	T32939	det	the,domain
R8407	T32939	T32936	conj	domain,domains
R8408	T32794	T32793	nummod	3,recombination
R8409	T32940	T32941	npadvmod	amino,terminal
R8410	T32941	T32939	amod	terminal,domain
R8411	T32942	T32941	punct	-,terminal
R8412	T32795	T32794	punct	′,3
R8413	T32943	T32939	compound	activation,domain
R8414	T32944	T32889	punct	.,exclude
R8415	T32946	T32947	mark	If,are
R8416	T32947	T32955	advcl	are,explain
R8417	T32796	T32793	amod	homologous,recombination
R8418	T32948	T32949	amod	small,amounts
R8419	T32949	T32947	nsubj	amounts,are
R8420	T32950	T32949	prep	of,amounts
R8421	T32797	T32793	acl	leading,recombination
R8422	T32951	T32952	compound	PGC,1α
R8423	T32952	T32954	compound	1α,activity
R8424	T32798	T32797	prep	to,leading
R8425	T32953	T32952	punct	-,1α
R8426	T32954	T32950	pobj	activity,of
R8427	T32799	T32800	det	an,insertion
R8428	T32956	T32947	acomp	present,are
R8429	T32957	T32947	prep	in,are
R8430	T32958	T32959	det	the,mice
R8431	T32800	T32798	pobj	insertion,to
R8432	T32959	T32957	pobj	mice,in
R8433	T32960	T32959	acl	reported,mice
R8434	T32801	T32800	prep	of,insertion
R8435	T32961	T32960	advmod	here,reported
R8436	T32962	T32955	punct	", ",explain
R8437	T32963	T32955	nsubj	it,explain
R8438	T32802	T32803	det	the,vector
R8439	T32964	T32955	aux	could,explain
R8440	T32965	T32955	dobj	some,explain
R8441	T32966	T32965	prep	of,some
R8442	T32803	T32801	pobj	vector,of
R8443	T32967	T32968	det	the,differences
R8444	T32968	T32966	pobj	differences,of
R8445	T32804	T32803	amod	targeting,vector
R8446	T32969	T32968	amod	observed,differences
R8447	T32970	T32968	prep	between,differences
R8448	T32971	T32972	det	the,models
R8449	T32805	T32800	prep	including,insertion
R8450	T32972	T32970	pobj	models,between
R8451	T32973	T32955	punct	.,explain
R8452	T32806	T32807	det	an,exon
R8453	T32975	T32976	advmod	However,support
R8454	T32807	T32805	pobj	exon,including
R8455	T32977	T32976	punct	", ",support
R8456	T32978	T32979	det	the,bulk
R8457	T32979	T32976	nsubj	bulk,support
R8458	T32808	T32807	amod	extra,exon
R8459	T32980	T32979	prep	of,bulk
R8460	T32981	T32980	pobj	data,of
R8461	T32809	T32807	nummod	3,exon
R8462	T32982	T32981	acl	presented,data
R8463	T32983	T32982	advmod	here,presented
R8464	T32984	T32985	det	the,conclusion
R8465	T32810	T32807	prep	between,exon
R8466	T32985	T32976	dobj	conclusion,support
R8467	T32986	T32987	mark	that,are
R8468	T32987	T32985	acl	are,conclusion
R8469	T32988	T32989	det	the,mice
R8470	T32989	T32987	nsubj	mice,are
R8471	T32811	T32812	nmod	exons,5
R8472	T32990	T32991	nmod	PGC,1α
R8473	T32991	T32989	nmod	1α,mice
R8474	T32992	T32991	punct	-,1α
R8475	T32812	T32810	pobj	5,between
R8476	T32993	T32991	punct	−,1α
R8477	T32994	T32991	punct	/,1α
R8478	T33025	T33023	pobj	summary,In
R8479	T32995	T32991	punct	−,1α
R8480	T32996	T32989	acl	described,mice
R8481	T32997	T32998	advmod	completely,deficient
R8482	T32998	T32987	acomp	deficient,are
R8483	T33026	T33024	punct	", ",provides
R8484	T32999	T32987	prep	in,are
R8485	T33000	T33001	compound	PGC,1α
R8486	T33001	T32999	pobj	1α,in
R8487	T33002	T33001	punct	-,1α
R8488	T33027	T33028	det	this,body
R8489	T33003	T32976	punct	.,support
R8490	T33028	T33024	nsubj	body,provides
R8491	T33005	T33006	amod	Future,comparison
R8492	T33006	T33008	nsubj	comparison,be
R8493	T33007	T33006	amod	direct,comparison
R8494	T33029	T33028	prep	of,body
R8495	T33009	T33006	prep	of,comparison
R8496	T33030	T33029	pobj	work,of
R8497	T33010	T33011	det	the,lines
R8498	T33031	T33024	dobj	evidence,provides
R8499	T33011	T33009	pobj	lines,of
R8500	T33012	T33011	nummod	two,lines
R8501	T33032	T33033	mark	that,is
R8502	T33013	T33011	compound	mouse,lines
R8503	T33014	T33011	prep	in,lines
R8504	T33015	T33016	amod	pure,strains
R8505	T33033	T33031	acl	is,evidence
R8506	T33016	T33014	pobj	strains,in
R8507	T33017	T33016	compound	background,strains
R8508	T33018	T33008	aux	will,be
R8509	T33034	T33035	compound	PGC,lα
R8510	T33019	T33008	prep	of,be
R8511	T33020	T33019	pobj	interest,of
R8512	T33021	T33008	punct	.,be
R8513	T33035	T33033	nsubj	lα,is
R8514	T33023	T33024	prep	In,provides
R8515	T33036	T33035	punct	-,lα
R8516	T33037	T33033	acomp	critical,is
R8517	T33038	T33037	prep	for,critical
R8518	T33039	T33040	det	the,responses
R8519	T33040	T33038	pobj	responses,for
R8520	T33131	T33130	punct	-,1α
R8521	T33041	T33040	amod	adaptive,responses
R8522	T33132	T33133	amod	null,mice
R8523	T33133	T33128	nsubj	mice,survive
R8524	T33042	T33040	amod	necessary,responses
R8525	T33134	T33128	prep	in,survive
R8526	T33135	T33136	det	the,environment
R8527	T33136	T33134	pobj	environment,in
R8528	T33043	T33044	aux	to,meet
R8529	T33137	T33136	amod	protected,environment
R8530	T33138	T33136	prep	of,environment
R8531	T33044	T33042	xcomp	meet,necessary
R8532	T33139	T33140	det	the,laboratory
R8533	T33140	T33138	pobj	laboratory,of
R8534	T33141	T33125	punct	", ",indicate
R8535	T33045	T33046	amod	postnatal,demands
R8536	T33142	T33143	poss	our,results
R8537	T33143	T33125	nsubj	results,indicate
R8538	T33144	T33145	mark	that,be
R8539	T33046	T33044	dobj	demands,meet
R8540	T33145	T33125	ccomp	be,indicate
R8541	T33146	T33145	prep	in,be
R8542	T33147	T33148	det	the,rigors
R8543	T33047	T33046	compound	energy,demands
R8544	T33148	T33146	pobj	rigors,in
R8545	T33149	T33148	prep	of,rigors
R8546	T33150	T33151	det	a,environment
R8547	T33048	T33024	punct	.,provides
R8548	T33151	T33149	pobj	environment,of
R8549	T33152	T33151	amod	typical,environment
R8550	T33050	T33051	poss	Our,results
R8551	T33153	T33151	amod	external,environment
R8552	T33154	T33145	punct	", ",be
R8553	T33155	T33156	compound	PGC,1α
R8554	T33156	T33145	nsubj	1α,be
R8555	T33051	T33052	nsubj	results,suggest
R8556	T33157	T33156	punct	-,1α
R8557	T33158	T33145	aux	would,be
R8558	T33159	T33145	acomp	necessary,be
R8559	T33053	T33052	advmod	also,suggest
R8560	T33160	T33159	prep	for,necessary
R8561	T33161	T33160	pobj	survival,for
R8562	T33162	T33125	punct	.,indicate
R8563	T33054	T33055	det	a,role
R8564	T33164	T33165	advmod	Lastly,propose
R8565	T33055	T33052	dobj	role,suggest
R8566	T33166	T33165	punct	", ",propose
R8567	T33167	T33165	nsubj	we,propose
R8568	T33168	T33169	mark	that,serve
R8569	T33056	T33055	amod	broader,role
R8570	T33169	T33165	ccomp	serve,propose
R8571	T33170	T33171	det	the,mice
R8572	T33171	T33169	nsubj	mice,serve
R8573	T33172	T33173	nmod	PGC,1α
R8574	T33173	T33171	nmod	1α,mice
R8575	T33174	T33173	punct	-,1α
R8576	T33057	T33055	prep	for,role
R8577	T33175	T33173	punct	−,1α
R8578	T33176	T33173	punct	/,1α
R8579	T33177	T33173	punct	−,1α
R8580	T33058	T33059	amod	inducible,coactivators
R8581	T33178	T33169	aux	should,serve
R8582	T33179	T33169	prep	as,serve
R8583	T33180	T33181	det	a,model
R8584	T33059	T33057	pobj	coactivators,for
R8585	T33060	T33059	amod	transcriptional,coactivators
R8587	T33061	T33062	amod	such,as
R8591	T33062	T33059	prep	as,coactivators
R8595	T33063	T33064	compound	PGC,1α
R8598	T33064	T33062	pobj	1α,as
R8602	T33065	T33064	punct	-,1α
R8605	T33066	T33055	prep	in,role
R8609	T33067	T33066	pcomp	transducing,in
R8613	T33068	T33069	amod	cellular,signals
R8617	T33069	T33067	dobj	signals,transducing
R8620	T33070	T33069	acl	triggered,signals
R8627	T33071	T33070	agent	by,triggered
R8630	T33072	T33073	amod	physiologic,cues
R8631	T33073	T33071	pobj	cues,by
R8632	T33074	T33072	cc	and,physiologic
R8633	T33075	T33072	conj	developmental,physiologic
R8634	T33076	T33067	prep	to,transducing
R8635	T33077	T33078	det	the,control
R8636	T33078	T33076	pobj	control,to
R8637	T33079	T33078	amod	transcriptional,control
R8638	T33080	T33078	prep	of,control
R8639	T33081	T33082	compound	energy,metabolism
R8640	T33082	T33080	pobj	metabolism,of
R8641	T33083	T33082	cc	and,metabolism
R8642	T33084	T33085	amod	other,processes
R8643	T33085	T33082	conj	processes,metabolism
R8644	T33086	T33085	amod	dynamic,processes
R8645	T33087	T33085	amod	cellular,processes
R8646	T33088	T33052	punct	.,suggest
R8647	T33090	T33091	prep	In,serves
R8648	T33092	T33093	det	this,regard
R8649	T33093	T33090	pobj	regard,In
R8650	T33094	T33091	punct	", ",serves
R8651	T33095	T33096	det	the,coactivator
R8652	T33096	T33091	nsubj	coactivator,serves
R8653	T33097	T33096	amod	inducible,coactivator
R8654	T33098	T33099	compound	PGC,1α
R8655	T33099	T33096	appos	1α,coactivator
R8656	T33100	T33099	punct	-,1α
R8657	T33101	T33091	prep	as,serves
R8658	T33102	T33103	det	a,booster
R8659	T33103	T33101	pobj	booster,as
R8660	T33104	T33103	amod	transcriptional,booster
R8661	T33105	T33103	punct	“,booster
R8662	T33106	T33103	punct	”,booster
R8663	T33107	T33108	aux	to,augment
R8664	T33108	T33103	advcl	augment,booster
R8665	T33109	T33110	det	the,capacity
R8666	T33110	T33108	dobj	capacity,augment
R8667	T33111	T33110	prep	of,capacity
R8668	T33112	T33113	amod	downstream,pathways
R8669	T33113	T33111	pobj	pathways,of
R8670	T33114	T33113	amod	metabolic,pathways
R8671	T33115	T33113	amod	critical,pathways
R8672	T33116	T33115	prep	for,critical
R8673	T33117	T33118	amod	metabolic,maturation
R8674	T33118	T33116	pobj	maturation,for
R8675	T33119	T33118	cc	and,maturation
R8676	T33120	T33121	amod	postnatal,growth
R8677	T33121	T33118	conj	growth,maturation
R8678	T33122	T33091	punct	.,serves
R8679	T33124	T33125	advmod	Indeed,indicate
R8680	T33126	T33125	punct	", ",indicate
R8681	T33127	T33128	mark	although,survive
R8682	T33128	T33125	advcl	survive,indicate
R8683	T33129	T33130	compound	PGC,1α
R8684	T33130	T33132	npadvmod	1α,null
R8687	T34069	T34070	det	the,gene
R8688	T34070	T34068	dobj	gene,Targeting
R8689	T34071	T34072	compound	PGC,1α
R8690	T34072	T34070	compound	1α,gene
R8691	T34073	T34072	punct	-,1α
R8692	T34074	T34068	prep	in,Targeting
R8693	T34075	T34074	pobj	mice,in
R8694	T34077	T34078	det	A,clone
R8695	T34078	T34081	nsubjpass	clone,obtained
R8696	T34079	T34078	nmod	BAC,clone
R8697	T34080	T34078	amod	genomic,clone
R8698	T34082	T34078	acl	containing,clone
R8699	T34083	T34084	det	the,gene
R8700	T34084	T34082	dobj	gene,containing
R8701	T34085	T34084	amod	murine,gene
R8702	T34086	T34087	compound	PGC,1α
R8703	T34087	T34084	compound	1α,gene
R8704	T34088	T34087	punct	-,1α
R8705	T34089	T34084	punct	", ",gene
R8706	T34090	T34084	acl	isolated,gene
R8707	T34091	T34090	prep	from,isolated
R8708	T34092	T34093	det	an,library
R8709	T34093	T34091	pobj	library,from
R8710	T34094	T34093	nmod	Sv129,library
R8711	T34095	T34093	amod	genomic,library
R8712	T34096	T34081	punct	", ",obtained
R8713	T34097	T34081	auxpass	was,obtained
R8714	T34098	T34081	prep	from,obtained
R8715	T34099	T34100	compound	Incyte,Genomics
R8716	T34100	T34098	pobj	Genomics,from
R8717	T34101	T34102	punct	(,Alto
R8718	T34102	T34100	parataxis	Alto,Genomics
R8719	T34103	T34102	compound	Palo,Alto
R8720	T34104	T34102	punct	", ",Alto
R8721	T34105	T34102	npadvmod	California,Alto
R8722	T34106	T34102	punct	", ",Alto
R8723	T34107	T34108	compound	United,States
R8724	T34108	T34102	npadvmod	States,Alto
R8725	T34109	T34102	punct	),Alto
R8726	T34110	T34081	punct	.,obtained
R8727	T34112	T34113	det	A,region
R8728	T34113	T34117	nsubjpass	region,amplified
R8729	T34114	T34115	nummod	3,kb
R8730	T34115	T34113	compound	kb,region
R8731	T34116	T34115	punct	-,kb
R8732	T34118	T34113	acl	spanning,region
R8733	T34119	T34118	dobj	exon,spanning
R8734	T34120	T34119	nummod	3,exon
R8735	T34121	T34117	auxpass	was,amplified
R8736	T34122	T34117	prep	from,amplified
R8737	T34123	T34124	det	the,clone
R8738	T34124	T34122	pobj	clone,from
R8739	T34125	T34124	amod	genomic,clone
R8740	T34126	T34117	punct	.,amplified
R8741	T34128	T34129	det	A,primer
R8742	T34129	T34132	nsubjpass	primer,designed
R8743	T34130	T34129	nummod	5,primer
R8744	T34131	T34130	punct	′,5
R8745	T34133	T34132	auxpass	was,designed
R8746	T34134	T34135	aux	to,amplify
R8747	T34135	T34132	advcl	amplify,designed
R8748	T34136	T34137	det	a,fragment
R8749	T34137	T34135	dobj	fragment,amplify
R8750	T34138	T34137	prep	with,fragment
R8751	T34139	T34140	det	the,end
R8752	T34140	T34143	nsubj	end,beginning
R8753	T34141	T34140	nummod	5,end
R8754	T34142	T34141	punct	′,5
R8755	T34143	T34138	pcomp	beginning,with
R8756	T34144	T34145	nummod	732,bp
R8757	T34145	T34146	npadvmod	bp,upstream
R8758	T34146	T34143	advmod	upstream,beginning
R8759	T34147	T34146	prep	of,upstream
R8760	T34148	T34147	pobj	exon,of
R8761	T34149	T34148	nummod	3,exon
R8762	T34150	T34151	advmod	just,upstream
R8763	T34151	T34143	advmod	upstream,beginning
R8764	T34152	T34151	prep	of,upstream
R8765	T34153	T34154	det	an,site
R8766	T34154	T34152	pobj	site,of
R8767	T34155	T34154	amod	endogenous,site
R8768	T34156	T34154	compound	Kpn1,site
R8769	T34157	T34154	compound	restriction,site
R8770	T34158	T34159	punct	(,AGTTTCCTTAGCAACTTCATA
R8771	T34159	T34154	parataxis	AGTTTCCTTAGCAACTTCATA,site
R8772	T34160	T34159	nummod	5,AGTTTCCTTAGCAACTTCATA
R8773	T34161	T34160	punct	′,5
R8774	T34162	T34159	punct	-,AGTTTCCTTAGCAACTTCATA
R8775	T34163	T34159	punct	-,AGTTTCCTTAGCAACTTCATA
R8776	T34164	T34159	nummod	3,AGTTTCCTTAGCAACTTCATA
R8777	T34165	T34159	punct	′,AGTTTCCTTAGCAACTTCATA
R8778	T34166	T34159	punct	),AGTTTCCTTAGCAACTTCATA
R8779	T34167	T34132	punct	.,designed
R8780	T34169	T34170	det	The,primer
R8781	T34170	T34173	nsubj	primer,contained
R8782	T34171	T34170	nummod	3,primer
R8783	T34172	T34171	punct	′,3
R8784	T34174	T34175	det	a,site
R8785	T34175	T34173	dobj	site,contained
R8786	T34176	T34175	compound	BamH1,site
R8787	T34177	T34175	acl	engineered,site
R8788	T34178	T34177	prep	by,engineered
R8789	T34179	T34178	pcomp	mutating,by
R8790	T34180	T34181	det	the,bases
R8791	T34181	T34179	dobj	bases,mutating
R8792	T34182	T34181	acl	shown,bases
R8793	T34183	T34182	prep	in,shown
R8794	T34184	T34183	pobj	lowercase,in
R8795	T34185	T34186	punct	(,AAGGATTTTAgGATcc CAGTAC
R8796	T34186	T34175	parataxis	AAGGATTTTAgGATcc CAGTAC,site
R8797	T34187	T34186	nummod	5,AAGGATTTTAgGATcc CAGTAC
R8798	T34188	T34187	punct	′,5
R8799	T34189	T34186	punct	-,AAGGATTTTAgGATcc CAGTAC
R8800	T34190	T34186	punct	-,AAGGATTTTAgGATcc CAGTAC
R8801	T34191	T34186	nummod	3,AAGGATTTTAgGATcc CAGTAC
R8802	T34192	T34186	punct	′,AAGGATTTTAgGATcc CAGTAC
R8803	T34193	T34186	punct	),AAGGATTTTAgGATcc CAGTAC
R8804	T34194	T34173	punct	.,contained
R8805	T34196	T34197	det	A,fragment
R8806	T34197	T34199	nsubjpass	fragment,amplified
R8807	T34198	T34197	amod	second,fragment
R8808	T34200	T34197	advmod	downstream,fragment
R8809	T34201	T34200	prep	of,downstream
R8810	T34202	T34201	pobj	exon,of
R8811	T34203	T34202	nummod	5,exon
R8812	T34204	T34199	auxpass	was,amplified
R8813	T34205	T34199	punct	.,amplified
R8814	T34207	T34208	prep	In,engineered
R8815	T34209	T34210	det	this,amplicon
R8816	T34210	T34207	pobj	amplicon,In
R8817	T34211	T34210	amod	latter,amplicon
R8818	T34212	T34208	punct	", ",engineered
R8819	T34213	T34214	nmod	Not1,sites
R8820	T34214	T34208	nsubjpass	sites,engineered
R8821	T34215	T34213	cc	and,Not1
R8822	T34216	T34213	conj	Xho1,Not1
R8823	T34217	T34208	auxpass	were,engineered
R8824	T34218	T34208	prep	into,engineered
R8825	T34219	T34220	det	the,5
R8826	T34220	T34221	nummod	5,primers
R8827	T34221	T34218	pobj	primers,into
R8828	T34222	T34220	punct	′,5
R8829	T34223	T34220	cc	and,5
R8830	T34224	T34220	conj	3,5
R8831	T34225	T34224	punct	′,3
R8832	T34226	T34208	punct	", ",engineered
R8833	T34227	T34208	advmod	respectively,engineered
R8834	T34228	T34229	punct	(,TGGAGTgc GGCCGCTGGGA
R8835	T34229	T34208	parataxis	TGGAGTgc GGCCGCTGGGA,engineered
R8836	T34230	T34229	nummod	5,TGGAGTgc GGCCGCTGGGA
R8837	T34231	T34230	punct	′,5
R8838	T34232	T34229	punct	-,TGGAGTgc GGCCGCTGGGA
R8839	T34233	T34229	punct	-,TGGAGTgc GGCCGCTGGGA
R8840	T34234	T34229	nummod	3,TGGAGTgc GGCCGCTGGGA
R8841	T34235	T34229	punct	′,TGGAGTgc GGCCGCTGGGA
R8842	T34236	T34229	cc	and,TGGAGTgc GGCCGCTGGGA
R8843	T34237	T34238	nummod	5,AAAGAGTCTCgAg AATAGTTTCT
R8844	T34238	T34229	conj	AAAGAGTCTCgAg AATAGTTTCT,TGGAGTgc GGCCGCTGGGA
R8845	T34239	T34237	punct	′,5
R8846	T34240	T34238	punct	-,AAAGAGTCTCgAg AATAGTTTCT
R8847	T34241	T34238	punct	-,AAAGAGTCTCgAg AATAGTTTCT
R8848	T34242	T34238	nummod	3,AAAGAGTCTCgAg AATAGTTTCT
R8849	T34243	T34238	punct	′,AAAGAGTCTCgAg AATAGTTTCT
R8850	T34244	T34229	punct	),TGGAGTgc GGCCGCTGGGA
R8851	T34245	T34208	punct	.,engineered
R8852	T34247	T34248	det	The,fragments
R8853	T34248	T34249	nsubjpass	fragments,cloned
R8854	T34250	T34249	auxpass	were,cloned
R8855	T34251	T34249	prep	into,cloned
R8856	T34252	T34253	compound	p1339,Neomycin
R8857	T34253	T34257	compound	Neomycin,vector
R8858	T34254	T34253	punct	-,Neomycin
R8859	T34255	T34253	compound	PGK,Neomycin
R8860	T34256	T34253	punct	-,Neomycin
R8861	T34257	T34251	pobj	vector,into
R8862	T34258	T34257	compound	targeting,vector
R8863	T34259	T34249	punct	.,cloned
R8864	T34261	T34262	det	The,construct
R8865	T34262	T34263	nsubjpass	construct,linearized
R8866	T34264	T34263	auxpass	was,linearized
R8867	T34265	T34263	prep	with,linearized
R8868	T34266	T34265	pobj	Xho1,with
R8869	T34267	T34263	cc	and,linearized
R8870	T34268	T34263	conj	electroporated,linearized
R8871	T34269	T34268	prep	into,electroporated
R8872	T34270	T34271	compound	RW4,cells
R8873	T34271	T34269	pobj	cells,into
R8874	T34272	T34271	compound	ES,cells
R8875	T34273	T34271	punct	(,cells
R8876	T34274	T34275	npadvmod	Sv129,derived
R8877	T34275	T34271	amod	derived,cells
R8878	T34276	T34268	punct	),electroporated
R8879	T34277	T34268	advcl	using,electroporated
R8880	T34278	T34279	compound	G418,selection
R8881	T34279	T34277	dobj	selection,using
R8882	T34280	T34263	punct	.,linearized
R8883	T34282	T34283	det	The,electroporation
R8884	T34283	T34284	nsubjpass	electroporation,performed
R8885	T34285	T34284	auxpass	was,performed
R8886	T34286	T34284	agent	by,performed
R8887	T34287	T34288	det	the,Core
R8888	T34288	T34286	pobj	Core,by
R8889	T34289	T34290	compound	Siteman,Center
R8890	T34290	T34288	compound	Center,Core
R8891	T34291	T34290	compound	Cancer,Center
R8892	T34292	T34293	compound	ES,Cell
R8893	T34293	T34288	compound	Cell,Core
R8894	T34294	T34288	prep	at,Core
R8895	T34295	T34296	compound	Washington,University
R8896	T34296	T34294	pobj	University,at
R8897	T34297	T34298	punct	(,Louis
R8898	T34298	T34296	parataxis	Louis,University
R8899	T34299	T34298	compound	St.,Louis
R8900	T34300	T34298	punct	", ",Louis
R8901	T34301	T34298	npadvmod	Missouri,Louis
R8902	T34302	T34298	punct	", ",Louis
R8903	T34303	T34304	compound	United,States
R8904	T34304	T34298	npadvmod	States,Louis
R8905	T34305	T34298	punct	),Louis
R8906	T34306	T34284	punct	.,performed
R8907	T34308	T34309	det	The,clones
R8908	T34309	T34310	nsubjpass	clones,screened
R8909	T34311	T34310	auxpass	were,screened
R8910	T34312	T34310	prep	by,screened
R8911	T34313	T34314	compound	Southern,blot
R8912	T34314	T34312	pobj	blot,by
R8913	T34315	T34310	advcl	using,screened
R8914	T34316	T34317	det	an,digest
R8915	T34317	T34315	dobj	digest,using
R8916	T34318	T34317	compound	Xba1,digest
R8917	T34319	T34320	punct	(,see
R8918	T34320	T34310	parataxis	see,screened
R8919	T34321	T34322	compound	Figure,1A
R8920	T34322	T34320	dobj	1A,see
R8921	T34323	T34322	cc	and,1A
R8922	T34324	T34322	conj	1B,1A
R8923	T34325	T34320	punct	),see
R8924	T34326	T34310	punct	.,screened
R8925	T34328	T34329	nummod	One,clone
R8926	T34329	T34330	nsubj	clone,was
R8927	T34331	T34329	prep	out,clone
R8928	T34332	T34331	prep	of,out
R8929	T34333	T34334	advmod	approximately,400
R8930	T34334	T34332	pobj	400,of
R8931	T34335	T34334	acl	screened,400
R8932	T34336	T34330	acomp	positive,was
R8933	T34337	T34336	prep	for,positive
R8934	T34338	T34339	det	the,recombination
R8935	T34339	T34337	pobj	recombination,for
R8936	T34340	T34339	amod	homologous,recombination
R8937	T34341	T34339	prep	on,recombination
R8938	T34342	T34343	det	the,end
R8939	T34343	T34341	pobj	end,on
R8940	T34344	T34343	nummod	3,end
R8941	T34345	T34344	punct	′,3
R8942	T34346	T34339	cc	and,recombination
R8943	T34347	T34348	det	an,insertion
R8944	T34348	T34339	conj	insertion,recombination
R8945	T34349	T34348	prep	on,insertion
R8946	T34350	T34351	det	the,end
R8947	T34351	T34349	pobj	end,on
R8948	T34352	T34351	nummod	5,end
R8949	T34353	T34352	punct	′,5
R8950	T34354	T34330	punct	.,was
R8951	T34356	T34357	det	This,clone
R8952	T34357	T34358	nsubjpass	clone,injected
R8953	T34359	T34358	auxpass	was,injected
R8954	T34360	T34358	prep	into,injected
R8955	T34361	T34362	det	a,blastocyst
R8956	T34362	T34360	pobj	blastocyst,into
R8957	T34363	T34364	compound	C57BL6,J
R8958	T34364	T34362	compound	J,blastocyst
R8959	T34365	T34364	punct	/,J
R8960	T34366	T34358	punct	.,injected
R8961	T34368	T34369	nsubjpass	Chimeras,mated
R8962	T34370	T34369	auxpass	were,mated
R8963	T34371	T34369	prep	to,mated
R8964	T34372	T34373	compound	C57BL6,J
R8965	T34373	T34375	compound	J,mice
R8966	T34374	T34373	punct	/,J
R8967	T34375	T34371	pobj	mice,to
R8968	T34376	T34369	cc	and,mated
R8969	T34377	T34378	compound	germline,transmission
R8970	T34378	T34379	nsubjpass	transmission,confirmed
R8971	T34379	T34369	conj	confirmed,mated
R8972	T34380	T34379	auxpass	was,confirmed
R8973	T34381	T34379	prep	by,confirmed
R8974	T34382	T34383	compound	Southern,blotting
R8975	T34383	T34381	pobj	blotting,by
R8976	T34384	T34383	prep	of,blotting
R8977	T34385	T34386	compound	tail,DNA
R8978	T34386	T34384	pobj	DNA,of
R8979	T34387	T34388	punct	(,see
R8980	T34388	T34379	parataxis	see,confirmed
R8981	T34389	T34390	compound	Figure,1B
R8982	T34390	T34388	dobj	1B,see
R8983	T34391	T34388	punct	),see
R8984	T34392	T34379	punct	.,confirmed
R8985	T34394	T34395	det	All,experiments
R8986	T34395	T34396	nsubjpass	experiments,performed
R8987	T34397	T34396	auxpass	were,performed
R8988	T34398	T34396	advcl	using,performed
R8989	T34399	T34400	npadvmod	sex,matched
R8990	T34400	T34405	amod	matched,controls
R8991	T34401	T34399	punct	-,sex
R8992	T34402	T34399	cc	and,sex
R8993	T34403	T34399	conj	age,sex
R8994	T34404	T34400	punct	-,matched
R8995	T34405	T34398	dobj	controls,using
R8996	T34406	T34400	cc	or,matched
R8997	T34407	T34400	conj	littermate,matched
R8998	T34408	T34409	mark	as,noted
R8999	T34409	T34396	advcl	noted,performed
R9000	T34410	T34396	punct	.,performed
R9001	T35414	T35415	amod	General,studies
R9002	T35416	T35415	compound	animal,studies
R9003	T35418	T35419	det	All,experiments
R9004	T35419	T35421	nsubjpass	experiments,conducted
R9005	T35420	T35419	compound	animal,experiments
R9006	T35422	T35419	cc	and,experiments
R9007	T35423	T35424	compound	euthanasia,protocols
R9008	T35424	T35419	conj	protocols,experiments
R9009	T35425	T35421	auxpass	were,conducted
R9010	T35426	T35421	prep	in,conducted
R9011	T35427	T35428	amod	strict,accordance
R9012	T35428	T35426	pobj	accordance,in
R9013	T35429	T35428	prep	with,accordance
R9014	T35430	T35431	det	the,Institutes
R9015	T35431	T35433	nmod	Institutes,guidelines
R9016	T35432	T35431	nmod	National,Institutes
R9017	T35433	T35429	pobj	guidelines,with
R9018	T35434	T35431	prep	of,Institutes
R9019	T35435	T35434	pobj	Health,of
R9020	T35436	T35433	prep	for,guidelines
R9021	T35437	T35438	compound	humane,treatment
R9022	T35438	T35436	pobj	treatment,for
R9023	T35439	T35438	prep	of,treatment
R9024	T35440	T35439	pobj	animals,of
R9025	T35441	T35421	cc	and,conducted
R9026	T35442	T35443	auxpass	were,reviewed
R9027	T35443	T35421	conj	reviewed,conducted
R9028	T35444	T35443	cc	and,reviewed
R9029	T35445	T35443	conj	approved,reviewed
R9030	T35446	T35445	agent	by,approved
R9031	T35447	T35448	det	the,Committee
R9032	T35448	T35446	pobj	Committee,by
R9033	T35449	T35450	compound	Animal,Care
R9034	T35450	T35448	compound	Care,Committee
R9035	T35451	T35448	prep	of,Committee
R9036	T35452	T35453	compound	Washington,University
R9037	T35453	T35451	pobj	University,of
R9038	T35454	T35421	punct	.,conducted
R9039	T35456	T35457	nsubjpass	Animals,weighed
R9040	T35458	T35457	auxpass	were,weighed
R9041	T35459	T35457	prep	at,weighed
R9042	T35460	T35461	amod	different,points
R9043	T35461	T35459	pobj	points,at
R9044	T35462	T35461	compound	time,points
R9045	T35463	T35457	punct	.,weighed
R9046	T35465	T35466	amod	Male,mice
R9047	T35466	T35490	nsubjpass	mice,euthanized
R9048	T35467	T35465	cc	and,Male
R9049	T35468	T35465	conj	female,Male
R9050	T35469	T35470	quantmod	3,8
R9051	T35470	T35473	nummod	8,wk
R9052	T35471	T35470	punct	-,8
R9053	T35472	T35470	quantmod	to,8
R9054	T35473	T35475	npadvmod	wk,old
R9055	T35474	T35473	punct	-,wk
R9056	T35475	T35466	amod	old,mice
R9057	T35476	T35475	punct	-,old
R9058	T35477	T35478	nmod	PGC,1α
R9059	T35478	T35466	nmod	1α,mice
R9060	T35479	T35478	punct	-,1α
R9061	T35480	T35478	punct	+,1α
R9062	T35481	T35478	punct	/,1α
R9063	T35482	T35478	punct	+,1α
R9064	T35483	T35478	cc	and,1α
R9065	T35484	T35485	compound	PGC,1α
R9066	T35485	T35478	conj	1α,1α
R9067	T35486	T35485	punct	-,1α
R9068	T35487	T35485	punct	−,1α
R9069	T35488	T35485	punct	/,1α
R9070	T35489	T35485	punct	−,1α
R9071	T35491	T35490	auxpass	were,euthanized
R9072	T35492	T35490	punct	", ",euthanized
R9073	T35493	T35490	cc	and,euthanized
R9074	T35494	T35495	nsubjpass	tissues,dissected
R9075	T35495	T35490	conj	dissected,euthanized
R9076	T35496	T35495	auxpass	were,dissected
R9077	T35497	T35495	cc	and,dissected
R9078	T35498	T35495	conj	weighed,dissected
R9079	T35499	T35498	prep	on,weighed
R9080	T35500	T35501	det	an,balance
R9081	T35501	T35499	pobj	balance,on
R9082	T35502	T35501	amod	analytical,balance
R9083	T35503	T35495	punct	.,dissected
R9084	T35505	T35506	compound	Tissue,weights
R9085	T35506	T35507	nsubjpass	weights,corrected
R9086	T35508	T35507	auxpass	were,corrected
R9087	T35509	T35507	prep	for,corrected
R9088	T35510	T35511	amod	total,weight
R9089	T35511	T35509	pobj	weight,for
R9090	T35512	T35511	compound	body,weight
R9091	T35513	T35507	prep	before,corrected
R9092	T35514	T35513	pobj	comparison,before
R9093	T35515	T35507	punct	.,corrected
R9094	T35517	T35518	compound	DEXA,studies
R9095	T35518	T35519	nsubjpass	studies,performed
R9096	T35520	T35519	auxpass	were,performed
R9097	T35521	T35522	mark	as,described
R9098	T35522	T35519	advcl	described,performed
R9099	T35523	T35522	advmod	previously,described
R9100	T35524	T35525	punct	[,39
R9101	T35525	T35522	parataxis	39,described
R9102	T35526	T35525	punct	],39
R9103	T35527	T35519	advcl	using,performed
R9104	T35528	T35529	det	a,system
R9105	T35529	T35527	dobj	system,using
R9106	T35530	T35529	compound	Lunar,system
R9107	T35531	T35529	compound	PIXIMUS,system
R9108	T35532	T35529	compound	DEXA,system
R9109	T35533	T35527	prep	at,using
R9110	T35534	T35535	nummod	10,wk
R9111	T35535	T35533	pobj	wk,at
R9112	T35536	T35534	punct	", ",10
R9113	T35537	T35534	conj	18,10
R9114	T35538	T35537	punct	", ",18
R9115	T35539	T35537	cc	and,18
R9116	T35540	T35537	conj	24,18
R9117	T35541	T35527	prep	in,using
R9118	T35542	T35543	amod	male,mice
R9119	T35543	T35541	pobj	mice,in
R9120	T35544	T35542	cc	and,male
R9121	T35545	T35542	conj	female,male
R9122	T35546	T35547	nmod	PGC,1α
R9123	T35547	T35543	nmod	1α,mice
R9124	T35548	T35547	punct	-,1α
R9125	T35549	T35547	punct	+,1α
R9126	T35550	T35547	punct	/,1α
R9127	T35551	T35547	punct	+,1α
R9128	T35552	T35547	cc	and,1α
R9129	T35553	T35554	compound	PGC,1α
R9130	T35554	T35547	conj	1α,1α
R9131	T35555	T35554	punct	-,1α
R9132	T35556	T35554	punct	−,1α
R9133	T35557	T35554	punct	/,1α
R9134	T35558	T35554	punct	−,1α
R9135	T35559	T35519	punct	.,performed
R9136	T35561	T35562	prep	For,housed
R9137	T35563	T35564	compound	cold,experiments
R9138	T35564	T35561	pobj	experiments,For
R9139	T35565	T35564	compound	exposure,experiments
R9140	T35566	T35562	punct	", ",housed
R9141	T35567	T35568	amod	male,mice
R9142	T35568	T35562	nsubjpass	mice,housed
R9143	T35569	T35567	cc	and,male
R9144	T35570	T35567	conj	female,male
R9145	T35571	T35572	nmod	PGC,1α
R9146	T35572	T35568	nmod	1α,mice
R9147	T35573	T35572	punct	-,1α
R9148	T35574	T35572	punct	+,1α
R9149	T35575	T35572	punct	/,1α
R9150	T35576	T35572	punct	+,1α
R9151	T35577	T35572	cc	and,1α
R9152	T35578	T35579	compound	PGC,1α
R9153	T35579	T35572	conj	1α,1α
R9154	T35580	T35579	punct	-,1α
R9155	T35581	T35579	punct	−,1α
R9156	T35582	T35579	punct	/,1α
R9157	T35583	T35579	punct	−,1α
R9158	T35584	T35562	auxpass	were,housed
R9159	T35585	T35562	advmod	singly,housed
R9160	T35586	T35562	cc	and,housed
R9161	T35587	T35562	conj	placed,housed
R9162	T35588	T35587	prep	at,placed
R9163	T35589	T35590	nummod	4,°C
R9164	T35590	T35588	pobj	°C,at
R9165	T35591	T35587	prep	for,placed
R9166	T35592	T35593	nummod	5,h
R9167	T35593	T35591	pobj	h,for
R9168	T35594	T35587	prep	without,placed
R9169	T35595	T35594	pobj	food,without
R9170	T35596	T35562	punct	.,housed
R9171	T35598	T35599	compound	Core,temperatures
R9172	T35599	T35601	nsubjpass	temperatures,monitored
R9173	T35600	T35599	compound	body,temperatures
R9174	T35602	T35601	auxpass	were,monitored
R9175	T35603	T35601	prep	by,monitored
R9176	T35604	T35605	amod	rectal,probe
R9177	T35605	T35603	pobj	probe,by
R9178	T35606	T35601	prep	at,monitored
R9179	T35607	T35606	pobj	baseline,at
R9180	T35608	T35607	cc	and,baseline
R9181	T35609	T35610	det	every,hour
R9182	T35610	T35607	conj	hour,baseline
R9183	T35611	T35610	advmod	thereafter,hour
R9184	T35612	T35601	punct	.,monitored
R9185	T35614	T35615	nsubjpass	Mice,monitored
R9186	T35616	T35615	auxpass	were,monitored
R9187	T35617	T35618	advmod	at,least
R9188	T35618	T35619	advmod	least,min
R9189	T35619	T35615	npadvmod	min,monitored
R9190	T35620	T35619	det	every,min
R9191	T35621	T35619	nummod	30,min
R9192	T35622	T35623	aux	to,check
R9193	T35623	T35615	advcl	check,monitored
R9194	T35624	T35623	prep	for,check
R9195	T35625	T35624	pobj	lethargy,for
R9196	T35626	T35615	punct	.,monitored
R9197	T35628	T35629	prep	At,sacrificed
R9198	T35630	T35631	det	the,end
R9199	T35631	T35628	pobj	end,At
R9200	T35632	T35631	prep	of,end
R9201	T35633	T35634	nummod	5,h
R9202	T35634	T35632	pobj	h,of
R9203	T35635	T35629	punct	", ",sacrificed
R9204	T35636	T35629	nsubjpass	mice,sacrificed
R9205	T35637	T35629	auxpass	were,sacrificed
R9206	T35638	T35629	cc	and,sacrificed
R9207	T35639	T35640	nsubj	tissues,harvested
R9208	T35640	T35629	conj	harvested,sacrificed
R9209	T35641	T35640	prep	for,harvested
R9210	T35642	T35643	nmod	RNA,extraction
R9211	T35643	T35641	pobj	extraction,for
R9212	T35644	T35642	cc	and,RNA
R9213	T35645	T35642	conj	protein,RNA
R9214	T35646	T35629	punct	.,sacrificed
R9215	T35648	T35649	prep	For,housed
R9216	T35650	T35651	compound	fasting,studies
R9217	T35651	T35648	pobj	studies,For
R9218	T35652	T35649	punct	", ",housed
R9219	T35653	T35649	nsubjpass	animals,housed
R9220	T35654	T35649	auxpass	were,housed
R9221	T35655	T35649	advmod	singly,housed
R9222	T35656	T35649	cc	and,housed
R9223	T35657	T35649	conj	given,housed
R9224	T35658	T35657	dobj	water,given
R9225	T35659	T35660	advmod	ad,libitum
R9226	T35660	T35657	advmod	libitum,given
R9227	T35661	T35649	punct	.,housed
R9228	T35663	T35664	nsubjpass	Food,removed
R9229	T35665	T35664	auxpass	was,removed
R9230	T35666	T35664	prep	from,removed
R9231	T35667	T35666	pobj	cages,from
R9232	T35668	T35664	prep	in,removed
R9233	T35669	T35670	det	the,morning
R9234	T35670	T35668	pobj	morning,in
R9235	T35671	T35664	cc	and,removed
R9236	T35672	T35673	nsubj	tissues,harvested
R9237	T35673	T35664	conj	harvested,removed
R9238	T35674	T35673	prep	at,harvested
R9239	T35675	T35676	nummod	24,h
R9240	T35676	T35674	pobj	h,at
R9241	T35677	T35673	prep	for,harvested
R9242	T35678	T35677	pobj	RNA,for
R9243	T35679	T35678	cc	and,RNA
R9244	T35680	T35678	conj	histology,RNA
R9245	T35681	T35673	punct	.,harvested
R9246	T35683	T35684	nsubjpass	Photography,performed
R9247	T35685	T35683	prep	of,Photography
R9248	T35686	T35687	det	the,mice
R9249	T35687	T35685	pobj	mice,of
R9250	T35688	T35684	auxpass	was,performed
R9251	T35689	T35684	agent	by,performed
R9252	T35690	T35689	pobj	MedPic,by
R9253	T35691	T35690	prep	at,MedPic
R9254	T35692	T35693	compound	Washington,University
R9255	T35693	T35694	compound	University,School
R9256	T35694	T35691	pobj	School,at
R9257	T35695	T35694	prep	of,School
R9258	T35696	T35695	pobj	Medicine,of
R9259	T35697	T35684	punct	.,performed
R9260	T35699	T35700	nummod	48,h
R9261	T35700	T35702	compound	h,monitoring
R9262	T35701	T35700	punct	-,h
R9263	T35702	T35704	nsubjpass	monitoring,performed
R9264	T35703	T35702	compound	activity,monitoring
R9265	T35705	T35704	auxpass	was,performed
R9266	T35706	T35704	agent	by,performed
R9267	T35707	T35708	compound	JAX,Services
R9268	T35708	T35706	pobj	Services,by
R9269	T35709	T35710	punct	(,Laboratory
R9270	T35710	T35708	parataxis	Laboratory,Services
R9271	T35711	T35710	det	The,Laboratory
R9272	T35712	T35710	compound	Jackson,Laboratory
R9273	T35713	T35710	punct	", ",Laboratory
R9274	T35714	T35715	compound	West,Sacramento
R9275	T35715	T35710	npadvmod	Sacramento,Laboratory
R9276	T35716	T35710	punct	", ",Laboratory
R9277	T35717	T35710	npadvmod	California,Laboratory
R9278	T35718	T35710	punct	", ",Laboratory
R9279	T35719	T35720	compound	United,States
R9280	T35720	T35710	npadvmod	States,Laboratory
R9281	T35721	T35710	punct	),Laboratory
R9282	T35722	T35704	advcl	using,performed
R9283	T35723	T35724	det	a,System
R9284	T35724	T35722	dobj	System,using
R9285	T35725	T35724	compound	Comprehensive,System
R9286	T35726	T35727	compound	Laboratory,Animal
R9287	T35727	T35724	compound	Animal,System
R9288	T35728	T35724	compound	Monitoring,System
R9289	T35729	T35730	punct	(,CLAMS
R9290	T35730	T35724	parataxis	CLAMS,System
R9291	T35731	T35730	punct	", ",CLAMS
R9292	T35732	T35733	compound	Columbus,Instruments
R9293	T35733	T35730	npadvmod	Instruments,CLAMS
R9294	T35734	T35730	punct	", ",CLAMS
R9295	T35735	T35730	npadvmod	Columbus,CLAMS
R9296	T35736	T35730	punct	", ",CLAMS
R9297	T35737	T35730	npadvmod	Ohio,CLAMS
R9298	T35738	T35730	punct	", ",CLAMS
R9299	T35739	T35740	compound	United,States
R9300	T35740	T35730	npadvmod	States,CLAMS
R9301	T35741	T35730	punct	),CLAMS
R9302	T35742	T35704	punct	.,performed
R9303	T35744	T35745	advmod	Briefly,acclimated
R9304	T35746	T35745	punct	", ",acclimated
R9305	T35747	T35748	nummod	3,mo
R9306	T35748	T35750	npadvmod	mo,old
R9307	T35749	T35748	punct	-,mo
R9308	T35750	T35752	amod	old,mice
R9309	T35751	T35750	punct	-,old
R9310	T35752	T35745	nsubjpass	mice,acclimated
R9311	T35753	T35752	amod	female,mice
R9312	T35754	T35745	auxpass	were,acclimated
R9313	T35755	T35745	prep	for,acclimated
R9314	T35756	T35757	nummod	17,h
R9315	T35757	T35755	pobj	h,for
R9316	T35758	T35745	prep	before,acclimated
R9317	T35759	T35760	compound	data,collection
R9318	T35760	T35758	pobj	collection,before
R9319	T35761	T35745	punct	.,acclimated
R9320	T35763	T35764	nsubjpass	Data,collected
R9321	T35765	T35764	auxpass	were,collected
R9322	T35766	T35767	det	every,min
R9323	T35767	T35764	npadvmod	min,collected
R9324	T35768	T35767	nummod	30,min
R9325	T35769	T35764	punct	.,collected
R9326	T35771	T35772	amod	Total,breaks
R9327	T35772	T35774	nsubjpass	breaks,tabulated
R9328	T35773	T35772	compound	beam,breaks
R9329	T35775	T35772	prep	in,breaks
R9330	T35776	T35777	det	the,direction
R9331	T35777	T35775	pobj	direction,in
R9332	T35778	T35777	compound	XY,direction
R9333	T35779	T35774	auxpass	were,tabulated
R9334	T35780	T35774	prep	for,tabulated
R9335	T35781	T35782	det	the,cycles
R9336	T35782	T35780	pobj	cycles,for
R9337	T35783	T35784	nummod	12,h
R9338	T35784	T35782	nmod	h,cycles
R9339	T35785	T35784	punct	-,h
R9340	T35786	T35782	nmod	light,cycles
R9341	T35787	T35786	cc	and,light
R9342	T35788	T35786	conj	dark,light
R9343	T35789	T35774	cc	and,tabulated
R9344	T35790	T35774	conj	compared,tabulated
R9345	T35791	T35790	prep	across,compared
R9346	T35792	T35791	pobj	genotypes,across
R9347	T35793	T35774	punct	.,tabulated
R9348	T36774	T36775	nmod	RNA,analyses
R9349	T36776	T36774	punct	", ",RNA
R9350	T36777	T36774	conj	DNA,RNA
R9351	T36778	T36777	punct	", ",DNA
R9352	T36779	T36777	cc	and,DNA
R9353	T36780	T36777	conj	protein,DNA
R9354	T36782	T36783	amod	Total,RNA
R9355	T36783	T36784	nsubjpass	RNA,isolated
R9356	T36785	T36784	auxpass	was,isolated
R9357	T36786	T36784	prep	by,isolated
R9358	T36787	T36788	det	the,method
R9359	T36788	T36786	pobj	method,by
R9360	T36789	T36788	compound	RNAzol,method
R9361	T36790	T36791	punct	(,Test
R9362	T36791	T36788	parataxis	Test,method
R9363	T36792	T36791	compound	Tel,Test
R9364	T36793	T36791	punct	-,Test
R9365	T36794	T36791	punct	", ",Test
R9366	T36795	T36791	npadvmod	Friendswood,Test
R9367	T36796	T36791	punct	", ",Test
R9368	T36797	T36791	npadvmod	Texas,Test
R9369	T36798	T36791	punct	),Test
R9370	T36799	T36784	cc	and,isolated
R9371	T36800	T36801	compound	Northern,blotting
R9372	T36801	T36802	nsubjpass	blotting,performed
R9373	T36802	T36784	conj	performed,isolated
R9374	T36803	T36802	auxpass	was,performed
R9375	T36804	T36805	mark	as,described
R9376	T36805	T36802	advcl	described,performed
R9377	T36806	T36805	advmod	previously,described
R9378	T36807	T36808	punct	[,40
R9379	T36808	T36805	parataxis	40,described
R9380	T36809	T36808	punct	],40
R9381	T36810	T36802	punct	.,performed
R9382	T36812	T36813	det	The,cDNAs
R9383	T36813	T36819	nsubj	cDNAs,were
R9384	T36814	T36815	nmod	PGC,1β
R9385	T36815	T36813	nmod	1β,cDNAs
R9386	T36816	T36815	punct	-,1β
R9387	T36817	T36815	cc	and,1β
R9388	T36818	T36815	conj	PRC,1β
R9389	T36820	T36821	amod	generous,gifts
R9390	T36821	T36819	attr	gifts,were
R9391	T36822	T36821	prep	from,gifts
R9392	T36823	T36824	compound	Bruce,Spiegelman
R9393	T36824	T36822	pobj	Spiegelman,from
R9394	T36825	T36824	cc	and,Spiegelman
R9395	T36826	T36827	compound	Richard,Scarpulla
R9396	T36827	T36824	conj	Scarpulla,Spiegelman
R9397	T36828	T36819	punct	", ",were
R9398	T36829	T36819	advmod	respectively,were
R9399	T36830	T36819	punct	.,were
R9400	T36832	T36833	det	The,cDNA
R9401	T36833	T36837	nsubj	cDNA,was
R9402	T36834	T36833	nmod	UCP,cDNA
R9403	T36835	T36834	punct	-,UCP
R9404	T36836	T36834	nummod	1,UCP
R9405	T36838	T36839	det	a,gift
R9406	T36839	T36837	attr	gift,was
R9407	T36840	T36839	prep	from,gift
R9408	T36841	T36842	compound	Daniel,Ricquier
R9409	T36842	T36840	pobj	Ricquier,from
R9410	T36843	T36837	punct	.,was
R9411	T36845	T36846	compound	RT,PCR
R9412	T36846	T36848	nsubjpass	PCR,performed
R9413	T36847	T36846	punct	-,PCR
R9414	T36849	T36848	auxpass	was,performed
R9415	T36850	T36851	mark	as,described
R9416	T36851	T36848	advcl	described,performed
R9417	T36852	T36853	punct	[,41
R9418	T36853	T36851	parataxis	41,described
R9419	T36854	T36853	punct	],41
R9420	T36855	T36848	punct	.,performed
R9421	T36857	T36858	prep	In,transcribed
R9422	T36859	T36857	amod	brief,In
R9423	T36860	T36858	punct	", ",transcribed
R9424	T36861	T36862	amod	total,RNA
R9425	T36862	T36858	nsubjpass	RNA,transcribed
R9426	T36863	T36862	acl	isolated,RNA
R9427	T36864	T36863	prep	from,isolated
R9428	T36865	T36866	compound	soleus,muscle
R9429	T36866	T36864	pobj	muscle,from
R9430	T36867	T36866	punct	", ",muscle
R9431	T36868	T36866	conj	BAT,muscle
R9432	T36869	T36868	punct	", ",BAT
R9433	T36870	T36868	cc	and,BAT
R9434	T36871	T36868	conj	heart,BAT
R9435	T36872	T36866	prep	of,muscle
R9436	T36873	T36874	quantmod	1,2
R9437	T36874	T36876	nummod	2,mo
R9438	T36875	T36874	punct	–,2
R9439	T36876	T36878	npadvmod	mo,old
R9440	T36877	T36876	punct	-,mo
R9441	T36878	T36880	amod	old,mice
R9442	T36879	T36878	punct	-,old
R9443	T36880	T36872	pobj	mice,of
R9444	T36881	T36882	nmod	PGC,1α
R9445	T36882	T36880	nmod	1α,mice
R9446	T36883	T36882	punct	-,1α
R9447	T36884	T36882	punct	+,1α
R9448	T36885	T36882	punct	/,1α
R9449	T36886	T36882	punct	+,1α
R9450	T36887	T36882	cc	or,1α
R9451	T36888	T36882	conj	PGCα,1α
R9452	T36889	T36888	punct	−,PGCα
R9453	T36890	T36888	punct	/,PGCα
R9454	T36891	T36888	punct	−,PGCα
R9455	T36892	T36858	auxpass	was,transcribed
R9456	T36893	T36858	advmod	reverse,transcribed
R9457	T36894	T36858	prep	with,transcribed
R9458	T36895	T36896	nmod	Taqman,reagents
R9459	T36896	T36894	pobj	reagents,with
R9460	T36897	T36898	amod	reverse,transcription
R9461	T36898	T36896	compound	transcription,reagents
R9462	T36899	T36900	punct	(,Biosystems
R9463	T36900	T36896	parataxis	Biosystems,reagents
R9464	T36901	T36900	compound	Applied,Biosystems
R9465	T36902	T36900	punct	", ",Biosystems
R9466	T36903	T36904	compound	Foster,City
R9467	T36904	T36900	npadvmod	City,Biosystems
R9468	T36905	T36900	punct	", ",Biosystems
R9469	T36906	T36900	npadvmod	California,Biosystems
R9470	T36907	T36900	punct	", ",Biosystems
R9471	T36908	T36909	compound	United,States
R9472	T36909	T36900	npadvmod	States,Biosystems
R9473	T36910	T36900	punct	),Biosystems
R9474	T36911	T36858	punct	.,transcribed
R9475	T36913	T36914	nsubjpass	Reactions,performed
R9476	T36915	T36914	auxpass	were,performed
R9477	T36916	T36914	prep	in,performed
R9478	T36917	T36916	pobj	triplicate,in
R9479	T36918	T36914	prep	in,performed
R9480	T36919	T36920	nummod	96,well
R9481	T36920	T36922	compound	well,format
R9482	T36921	T36920	punct	-,well
R9483	T36922	T36918	pobj	format,in
R9484	T36923	T36914	advcl	using,performed
R9485	T36924	T36925	compound	Taqman,reagents
R9486	T36925	T36923	dobj	reagents,using
R9487	T36926	T36925	compound	core,reagents
R9488	T36927	T36925	cc	and,reagents
R9489	T36928	T36929	det	a,Detector
R9490	T36929	T36925	conj	Detector,reagents
R9491	T36930	T36929	nmod	Prism,Detector
R9492	T36931	T36930	nummod	7500,Prism
R9493	T36932	T36929	compound	Sequence,Detector
R9494	T36933	T36934	punct	(,Biosystems
R9495	T36934	T36929	parataxis	Biosystems,Detector
R9496	T36935	T36934	compound	Applied,Biosystems
R9497	T36936	T36934	punct	),Biosystems
R9498	T36937	T36914	punct	.,performed
R9499	T36939	T36940	det	The,sets
R9500	T36940	T36947	nsubjpass	sets,found
R9501	T36941	T36942	npadvmod	mouse,specific
R9502	T36942	T36940	amod	specific,sets
R9503	T36943	T36942	punct	-,specific
R9504	T36944	T36945	compound	primer,probe
R9505	T36945	T36940	compound	probe,sets
R9506	T36946	T36945	punct	-,probe
R9507	T36948	T36940	acl	used,sets
R9508	T36949	T36950	aux	to,detect
R9509	T36950	T36948	advcl	detect,used
R9510	T36951	T36952	amod	specific,expression
R9511	T36952	T36950	dobj	expression,detect
R9512	T36953	T36952	compound	gene,expression
R9513	T36954	T36947	aux	can,found
R9514	T36955	T36947	auxpass	be,found
R9515	T36956	T36947	prep	in,found
R9516	T36957	T36958	compound	Table,S1
R9517	T36958	T36956	pobj	S1,in
R9518	T36959	T36947	punct	.,found
R9519	T36961	T36962	det	The,primers
R9520	T36962	T36963	nsubjpass	primers,described
R9521	T36964	T36962	prep	for,primers
R9522	T36965	T36964	pobj	UCP,for
R9523	T36966	T36965	punct	-,UCP
R9524	T36967	T36965	nummod	1,UCP
R9525	T36968	T36963	aux	have,described
R9526	T36969	T36963	auxpass	been,described
R9527	T36970	T36963	advmod	previously,described
R9528	T36971	T36972	punct	[,42
R9529	T36972	T36963	parataxis	42,described
R9530	T36973	T36972	punct	],42
R9531	T36974	T36963	punct	.,described
R9532	T36976	T36977	compound	Actin,set
R9533	T36977	T36981	nsubjpass	set,included
R9534	T36978	T36979	compound	primer,probe
R9535	T36979	T36977	compound	probe,set
R9536	T36980	T36979	punct	-,probe
R9537	T36982	T36983	punct	(,Biosystems
R9538	T36983	T36977	parataxis	Biosystems,set
R9539	T36984	T36983	compound	Applied,Biosystems
R9540	T36985	T36983	punct	),Biosystems
R9541	T36986	T36981	auxpass	was,included
R9542	T36987	T36981	prep	in,included
R9543	T36988	T36989	det	a,well
R9544	T36989	T36987	pobj	well,in
R9545	T36990	T36989	amod	separate,well
R9546	T36991	T36981	cc	and,included
R9547	T36992	T36981	conj	used,included
R9548	T36993	T36994	aux	to,normalize
R9549	T36994	T36992	advcl	normalize,used
R9550	T36995	T36996	det	the,data
R9551	T36996	T36994	dobj	data,normalize
R9552	T36997	T36996	nmod	soleus,data
R9553	T36998	T36997	punct	", ",soleus
R9554	T36999	T36997	conj	BAT,soleus
R9555	T37000	T36999	punct	", ",BAT
R9556	T37001	T36999	cc	and,BAT
R9557	T37002	T37003	compound	heart,gene
R9558	T37003	T36999	conj	gene,BAT
R9559	T37004	T36996	compound	expression,data
R9560	T37005	T36981	punct	.,included
R9561	T37007	T37008	compound	GAPDH,primers
R9562	T37008	T37010	nsubjpass	primers,used
R9563	T37009	T37008	compound	Rodent,primers
R9564	T37011	T37012	punct	(,Biosystems
R9565	T37012	T37008	parataxis	Biosystems,primers
R9566	T37013	T37012	compound	Applied,Biosystems
R9567	T37014	T37012	punct	),Biosystems
R9568	T37015	T37010	auxpass	were,used
R9569	T37016	T37010	prep	in,used
R9570	T37017	T37018	det	the,well
R9571	T37018	T37016	pobj	well,in
R9572	T37019	T37018	amod	same,well
R9573	T37020	T37021	aux	to,normalize
R9574	T37021	T37010	advcl	normalize,used
R9575	T37022	T37023	det	the,data
R9576	T37023	T37021	dobj	data,normalize
R9577	T37024	T37025	compound	liver,gene
R9578	T37025	T37023	compound	gene,data
R9579	T37026	T37023	compound	expression,data
R9580	T37027	T37010	punct	.,used
R9581	T37029	T37030	prep	For,digested
R9582	T37031	T37032	compound	Southern,blot
R9583	T37032	T37033	compound	blot,studies
R9584	T37033	T37029	pobj	studies,For
R9585	T37034	T37030	punct	", ",digested
R9586	T37035	T37036	nummod	5,μg
R9587	T37036	T37030	nsubjpass	μg,digested
R9588	T37037	T37036	prep	of,μg
R9589	T37038	T37039	amod	genomic,DNA
R9590	T37039	T37037	pobj	DNA,of
R9591	T37040	T37030	auxpass	was,digested
R9592	T37041	T37030	prep	with,digested
R9593	T37042	T37041	pobj	Pst1,with
R9594	T37043	T37042	cc	or,Pst1
R9595	T37044	T37042	conj	Xba1,Pst1
R9596	T37045	T37030	punct	", ",digested
R9597	T37046	T37030	conj	electrophoresed,digested
R9598	T37047	T37046	prep	on,electrophoresed
R9599	T37048	T37049	det	a,gel
R9600	T37049	T37047	pobj	gel,on
R9601	T37050	T37051	nummod	0.8,%
R9602	T37051	T37052	compound	%,TAE
R9603	T37052	T37049	compound	TAE,gel
R9604	T37053	T37046	cc	and,electrophoresed
R9605	T37054	T37046	conj	transferred,electrophoresed
R9606	T37055	T37054	prep	to,transferred
R9607	T37056	T37057	det	a,membrane
R9608	T37057	T37055	pobj	membrane,to
R9609	T37058	T37059	nmod	Gene,Screen
R9610	T37059	T37057	nmod	Screen,membrane
R9611	T37060	T37061	punct	(,Elmer
R9612	T37061	T37059	parataxis	Elmer,Screen
R9613	T37062	T37061	compound	Perkin,Elmer
R9614	T37063	T37061	punct	", ",Elmer
R9615	T37064	T37061	npadvmod	Wellesley,Elmer
R9616	T37065	T37061	punct	", ",Elmer
R9617	T37066	T37061	npadvmod	California,Elmer
R9618	T37067	T37061	punct	", ",Elmer
R9619	T37068	T37069	compound	United,States
R9620	T37069	T37061	npadvmod	States,Elmer
R9621	T37070	T37061	punct	),Elmer
R9622	T37071	T37054	prep	for,transferred
R9623	T37072	T37071	pobj	hybridization,for
R9624	T37073	T37030	punct	.,digested
R9625	T37075	T37076	compound	Western,blotting
R9626	T37076	T37077	nsubjpass	blotting,performed
R9627	T37078	T37077	auxpass	was,performed
R9628	T37079	T37080	mark	as,described
R9629	T37080	T37077	advcl	described,performed
R9630	T37081	T37082	punct	[,43
R9631	T37082	T37080	parataxis	43,described
R9632	T37083	T37082	punct	],43
R9633	T37084	T37077	advcl	using,performed
R9634	T37085	T37086	det	the,system
R9635	T37086	T37084	dobj	system,using
R9636	T37087	T37088	amod	Enhanced,Chemiluminescence
R9637	T37088	T37086	compound	Chemiluminescence,system
R9638	T37089	T37086	compound	detection,system
R9639	T37090	T37091	punct	(,Biotech
R9640	T37091	T37086	parataxis	Biotech,system
R9641	T37092	T37091	compound	Amersham,Biotech
R9642	T37093	T37091	compound	Pharmacia,Biotech
R9643	T37094	T37091	punct	", ",Biotech
R9644	T37095	T37091	npadvmod	Piscataway,Biotech
R9645	T37096	T37091	punct	", ",Biotech
R9646	T37097	T37098	compound	New,Jersey
R9647	T37098	T37091	npadvmod	Jersey,Biotech
R9648	T37099	T37091	punct	", ",Biotech
R9649	T37100	T37101	compound	United,States
R9650	T37101	T37091	npadvmod	States,Biotech
R9651	T37102	T37091	punct	),Biotech
R9652	T37103	T37077	punct	.,performed
R9653	T37105	T37106	nmod	Ponceau,S
R9654	T37106	T37107	nmod	S,staining
R9655	T37107	T37119	nsubjpass	staining,used
R9656	T37108	T37109	punct	(,Sigma
R9657	T37109	T37106	parataxis	Sigma,S
R9658	T37110	T37109	punct	", ",Sigma
R9659	T37111	T37112	compound	St.,Louis
R9660	T37112	T37109	npadvmod	Louis,Sigma
R9661	T37113	T37109	punct	", ",Sigma
R9662	T37114	T37109	npadvmod	Missouri,Sigma
R9663	T37115	T37109	punct	", ",Sigma
R9664	T37116	T37117	compound	United,States
R9665	T37117	T37109	npadvmod	States,Sigma
R9666	T37118	T37109	punct	),Sigma
R9667	T37120	T37107	prep	of,staining
R9668	T37121	T37122	det	the,membrane
R9669	T37122	T37120	pobj	membrane,of
R9670	T37123	T37119	auxpass	was,used
R9671	T37124	T37119	prep	as,used
R9672	T37125	T37126	det	a,control
R9673	T37126	T37124	pobj	control,as
R9674	T37127	T37119	punct	.,used
R9675	T38198	T38199	amod	Mitochondrial,respiration
R9676	T38199	T38200	compound	respiration,studies
R9677	T38202	T38203	amod	Mitochondrial,respiration
R9678	T38203	T38204	nsubjpass	respiration,assessed
R9679	T38205	T38204	auxpass	was,assessed
R9680	T38206	T38204	prep	in,assessed
R9681	T38207	T38208	npadvmod	saponin,skinned
R9682	T38208	T38210	amod	skinned,fibers
R9683	T38209	T38208	punct	-,skinned
R9684	T38210	T38206	pobj	fibers,in
R9685	T38211	T38210	compound	soleus,fibers
R9686	T38212	T38204	prep	with,assessed
R9687	T38213	T38212	pobj	succinate,with
R9688	T38214	T38213	prep	as,succinate
R9689	T38215	T38214	pobj	substrate,as
R9690	T38216	T38212	cc	and,with
R9691	T38217	T38212	conj	in,with
R9692	T38218	T38219	det	the,presence
R9693	T38219	T38217	pobj	presence,in
R9694	T38220	T38219	prep	of,presence
R9695	T38221	T38220	pobj	rotenone,of
R9696	T38222	T38223	mark	as,described
R9697	T38223	T38204	advcl	described,assessed
R9698	T38224	T38223	advmod	previously,described
R9699	T38225	T38226	punct	[,44
R9700	T38226	T38223	parataxis	44,described
R9701	T38227	T38226	punct	],44
R9702	T38228	T38204	punct	.,assessed
R9703	T38230	T38231	prep	In,anesthetized
R9704	T38232	T38230	amod	brief,In
R9705	T38233	T38231	punct	", ",anesthetized
R9706	T38234	T38235	nummod	3,mo
R9707	T38235	T38237	npadvmod	mo,old
R9708	T38236	T38235	punct	-,mo
R9709	T38237	T38239	amod	old,mice
R9710	T38238	T38237	punct	-,old
R9711	T38239	T38231	nsubjpass	mice,anesthetized
R9712	T38240	T38239	amod	female,mice
R9713	T38241	T38231	auxpass	were,anesthetized
R9714	T38242	T38231	prep	with,anesthetized
R9715	T38243	T38244	amod	chloral,hydrate
R9716	T38244	T38242	pobj	hydrate,with
R9717	T38245	T38246	punct	(,mg
R9718	T38246	T38244	parataxis	mg,hydrate
R9719	T38247	T38246	nummod	400,mg
R9720	T38248	T38249	punct	/,kg
R9721	T38249	T38246	prep	kg,mg
R9722	T38250	T38249	prep	of,kg
R9723	T38251	T38252	compound	body,weight
R9724	T38252	T38250	pobj	weight,of
R9725	T38253	T38246	punct	),mg
R9726	T38254	T38231	punct	.,anesthetized
R9727	T38256	T38257	compound	Soleus,fibers
R9728	T38257	T38258	nsubjpass	fibers,separated
R9729	T38259	T38258	auxpass	were,separated
R9730	T38260	T38258	cc	and,separated
R9731	T38261	T38262	advmod	then,transferred
R9732	T38262	T38258	conj	transferred,separated
R9733	T38263	T38262	prep	to,transferred
R9734	T38264	T38265	det	a,buffer
R9735	T38265	T38263	pobj	buffer,to
R9736	T38266	T38265	punct	(,buffer
R9737	T38267	T38268	nummod	2.77,mM
R9738	T38268	T38269	compound	mM,EGTA
R9739	T38269	T38265	appos	EGTA,buffer
R9740	T38270	T38269	compound	K2Ca,EGTA
R9741	T38271	T38269	punct	-,EGTA
R9742	T38272	T38269	punct	", ",EGTA
R9743	T38273	T38274	nummod	7.23,mM
R9744	T38274	T38275	compound	mM,K2EGTA
R9745	T38275	T38269	appos	K2EGTA,EGTA
R9746	T38276	T38269	punct	", ",EGTA
R9747	T38277	T38278	nummod	6.56,mM
R9748	T38278	T38279	compound	mM,MgCl2
R9749	T38279	T38269	appos	MgCl2,EGTA
R9750	T38280	T38269	punct	", ",EGTA
R9751	T38281	T38282	nummod	20,mM
R9752	T38282	T38283	compound	mM,imidazole
R9753	T38283	T38269	appos	imidazole,EGTA
R9754	T38284	T38269	punct	", ",EGTA
R9755	T38285	T38286	nummod	53.3,mM
R9756	T38286	T38287	compound	mM,MES
R9757	T38287	T38269	appos	MES,EGTA
R9758	T38288	T38287	compound	K,MES
R9759	T38289	T38287	punct	-,MES
R9760	T38290	T38269	punct	", ",EGTA
R9761	T38291	T38292	nummod	20,mM
R9762	T38292	T38293	compound	mM,taurine
R9763	T38293	T38269	appos	taurine,EGTA
R9764	T38294	T38269	punct	", ",EGTA
R9765	T38295	T38296	nummod	5.3,mM
R9766	T38296	T38297	compound	mM,ATP
R9767	T38297	T38269	appos	ATP,EGTA
R9768	T38298	T38269	punct	", ",EGTA
R9769	T38299	T38300	nummod	15,mM
R9770	T38300	T38301	compound	mM,PCr
R9771	T38301	T38269	appos	PCr,EGTA
R9772	T38302	T38269	punct	", ",EGTA
R9773	T38303	T38304	nummod	3,mM
R9774	T38304	T38305	compound	mM,KH2PO4
R9775	T38305	T38269	appos	KH2PO4,EGTA
R9776	T38306	T38269	punct	", ",EGTA
R9777	T38307	T38308	nummod	0.5,mM
R9778	T38308	T38309	compound	mM,DTT
R9779	T38309	T38269	appos	DTT,EGTA
R9780	T38310	T38311	punct	[,pH
R9781	T38311	T38269	parataxis	pH,EGTA
R9782	T38312	T38311	nummod	7.1,pH
R9783	T38313	T38311	punct	],pH
R9784	T38314	T38265	punct	),buffer
R9785	T38315	T38265	acl	supplemented,buffer
R9786	T38316	T38315	prep	with,supplemented
R9787	T38317	T38318	nummod	50,μg
R9788	T38318	T38316	pobj	μg,with
R9789	T38319	T38320	punct	/,saponin
R9790	T38320	T38318	prep	saponin,μg
R9791	T38321	T38320	compound	ml,saponin
R9792	T38322	T38315	cc	and,supplemented
R9793	T38323	T38315	conj	permeabilized,supplemented
R9794	T38324	T38323	prep	for,permeabilized
R9795	T38325	T38326	nummod	30,min
R9796	T38326	T38324	pobj	min,for
R9797	T38327	T38323	prep	at,permeabilized
R9798	T38328	T38329	nummod	4,°C
R9799	T38329	T38327	pobj	°C,at
R9800	T38330	T38323	prep	with,permeabilized
R9801	T38331	T38332	amod	gentle,stirring
R9802	T38332	T38330	pobj	stirring,with
R9803	T38333	T38258	punct	.,separated
R9804	T38335	T38336	nsubjpass	Fibers,washed
R9805	T38337	T38336	auxpass	were,washed
R9806	T38338	T38336	advmod	then,washed
R9807	T38339	T38336	advmod	twice,washed
R9808	T38340	T38336	prep	for,washed
R9809	T38341	T38342	nummod	10,min
R9810	T38342	T38340	pobj	min,for
R9811	T38343	T38342	advmod	each,min
R9812	T38344	T38345	punct	(,EGTA
R9813	T38345	T38336	parataxis	EGTA,washed
R9814	T38346	T38347	nummod	2.77,mM
R9815	T38347	T38345	compound	mM,EGTA
R9816	T38348	T38345	compound	K2Ca,EGTA
R9817	T38349	T38345	punct	-,EGTA
R9818	T38350	T38345	punct	", ",EGTA
R9819	T38351	T38352	nummod	7.23,mM
R9820	T38352	T38353	compound	mM,K2EGTA
R9821	T38353	T38345	appos	K2EGTA,EGTA
R9822	T38354	T38345	punct	", ",EGTA
R9823	T38355	T38356	nummod	1.38,mM
R9824	T38356	T38357	compound	mM,MgCl2
R9825	T38357	T38345	appos	MgCl2,EGTA
R9826	T38358	T38345	punct	", ",EGTA
R9827	T38359	T38360	nummod	20,mM
R9828	T38360	T38361	compound	mM,imidazole
R9829	T38361	T38345	appos	imidazole,EGTA
R9830	T38362	T38345	punct	", ",EGTA
R9831	T38363	T38364	nummod	100,mM
R9832	T38364	T38365	compound	mM,MES
R9833	T38365	T38345	appos	MES,EGTA
R9834	T38366	T38365	compound	K,MES
R9835	T38367	T38365	punct	-,MES
R9836	T38368	T38345	punct	", ",EGTA
R9837	T38369	T38370	nummod	20,mM
R9838	T38370	T38371	compound	mM,taurine
R9839	T38371	T38345	appos	taurine,EGTA
R9840	T38372	T38345	punct	", ",EGTA
R9841	T38373	T38374	nummod	3,mM
R9842	T38374	T38375	compound	mM,KH2PO4
R9843	T38375	T38345	appos	KH2PO4,EGTA
R9844	T38376	T38345	punct	", ",EGTA
R9845	T38377	T38378	nummod	0.5,mM
R9846	T38378	T38379	compound	mM,DTT
R9847	T38379	T38345	appos	DTT,EGTA
R9848	T38380	T38345	punct	", ",EGTA
R9849	T38381	T38382	nummod	2,mg
R9850	T38382	T38345	appos	mg,EGTA
R9851	T38383	T38384	punct	/,BSA
R9852	T38384	T38382	prep	BSA,mg
R9853	T38385	T38384	compound	ml,BSA
R9854	T38386	T38387	punct	[,pH
R9855	T38387	T38345	parataxis	pH,EGTA
R9856	T38388	T38387	nummod	7.1,pH
R9857	T38389	T38387	punct	],pH
R9858	T38390	T38345	punct	),EGTA
R9859	T38391	T38336	punct	.,washed
R9860	T38393	T38394	nsubjpass	Respiration,measured
R9861	T38395	T38394	auxpass	was,measured
R9862	T38396	T38394	prep	at,measured
R9863	T38397	T38398	nummod	25,°C
R9864	T38398	T38396	pobj	°C,at
R9865	T38399	T38394	advcl	using,measured
R9866	T38400	T38401	det	an,probe
R9867	T38401	T38399	dobj	probe,using
R9868	T38402	T38401	amod	optical,probe
R9869	T38403	T38404	punct	(,Probe
R9870	T38404	T38401	parataxis	Probe,probe
R9871	T38405	T38404	compound	Oxygen,Probe
R9872	T38406	T38404	compound	FOXY,Probe
R9873	T38407	T38404	punct	", ",Probe
R9874	T38408	T38409	compound	Ocean,Optics
R9875	T38409	T38404	npadvmod	Optics,Probe
R9876	T38410	T38404	punct	", ",Probe
R9877	T38411	T38404	npadvmod	Dunedin,Probe
R9878	T38412	T38404	punct	", ",Probe
R9879	T38413	T38404	npadvmod	Florida,Probe
R9880	T38414	T38404	punct	", ",Probe
R9881	T38415	T38416	compound	United,States
R9882	T38416	T38404	npadvmod	States,Probe
R9883	T38417	T38404	punct	),Probe
R9884	T38418	T38394	punct	.,measured
R9885	T38420	T38421	prep	Following,determined
R9886	T38422	T38420	pobj	measurement,Following
R9887	T38423	T38422	prep	of,measurement
R9888	T38424	T38425	amod	basal,respiration
R9889	T38425	T38423	pobj	respiration,of
R9890	T38426	T38425	nmod	state,respiration
R9891	T38427	T38426	nummod	2,state
R9892	T38428	T38421	punct	", ",determined
R9893	T38429	T38430	amod	maximal,respiration
R9894	T38430	T38421	nsubjpass	respiration,determined
R9895	T38431	T38430	punct	(,respiration
R9896	T38432	T38433	npadvmod	ADP,stimulated
R9897	T38433	T38430	amod	stimulated,respiration
R9898	T38434	T38433	punct	-,stimulated
R9899	T38435	T38430	punct	),respiration
R9900	T38436	T38430	nmod	state,respiration
R9901	T38437	T38436	nummod	3,state
R9902	T38438	T38421	auxpass	was,determined
R9903	T38439	T38421	prep	by,determined
R9904	T38440	T38439	pcomp	exposing,by
R9905	T38441	T38440	dobj	fibers,exposing
R9906	T38442	T38440	prep	to,exposing
R9907	T38443	T38444	nummod	1,mM
R9908	T38444	T38445	compound	mM,ADP
R9909	T38445	T38442	pobj	ADP,to
R9910	T38446	T38421	punct	.,determined
R9911	T38448	T38449	det	The,integrity
R9912	T38449	T38450	nsubjpass	integrity,assessed
R9913	T38451	T38449	prep	of,integrity
R9914	T38452	T38453	det	the,membrane
R9915	T38453	T38451	pobj	membrane,of
R9916	T38454	T38453	amod	outer,membrane
R9917	T38455	T38453	amod	mitochondrial,membrane
R9918	T38456	T38450	auxpass	was,assessed
R9919	T38457	T38450	prep	by,assessed
R9920	T38458	T38457	pcomp	adding,by
R9921	T38459	T38460	nummod	8,μM
R9922	T38460	T38461	nmod	μM,c
R9923	T38461	T38458	dobj	c,adding
R9924	T38462	T38461	amod	exogenous,c
R9925	T38463	T38461	compound	cytochrome,c
R9926	T38464	T38458	prep	to,adding
R9927	T38465	T38466	npadvmod	ADP,stimulated
R9928	T38466	T38468	amod	stimulated,fibers
R9929	T38467	T38466	punct	-,stimulated
R9930	T38468	T38464	pobj	fibers,to
R9931	T38469	T38450	punct	.,assessed
R9932	T38471	T38472	nmod	State,respiration
R9933	T38472	T38474	nsubjpass	respiration,evaluated
R9934	T38473	T38471	nummod	4,State
R9935	T38475	T38476	punct	(,uncoupled
R9936	T38476	T38472	parataxis	uncoupled,respiration
R9937	T38477	T38476	punct	),uncoupled
R9938	T38478	T38474	auxpass	was,evaluated
R9939	T38479	T38474	prep	following,evaluated
R9940	T38480	T38479	pobj	addition,following
R9941	T38481	T38480	prep	of,addition
R9942	T38482	T38481	pobj	oligomycin,of
R9943	T38483	T38484	punct	(,μg
R9944	T38484	T38482	parataxis	μg,oligomycin
R9945	T38485	T38484	nummod	1,μg
R9946	T38486	T38487	punct	/,ml
R9947	T38487	T38484	prep	ml,μg
R9948	T38488	T38484	punct	),μg
R9949	T38489	T38474	punct	.,evaluated
R9950	T38491	T38492	det	The,solubility
R9951	T38492	T38493	nsubjpass	solubility,taken
R9952	T38494	T38492	prep	of,solubility
R9953	T38495	T38494	pobj	oxygen,of
R9954	T38496	T38492	prep	in,solubility
R9955	T38497	T38498	det	the,buffer
R9956	T38498	T38496	pobj	buffer,in
R9957	T38499	T38498	compound	respiration,buffer
R9958	T38500	T38492	prep	at,solubility
R9959	T38501	T38502	nummod	25,°C
R9960	T38502	T38500	pobj	°C,at
R9961	T38503	T38493	auxpass	was,taken
R9962	T38504	T38493	prep	as,taken
R9963	T38505	T38506	nummod	246.87,nmol
R9964	T38506	T38507	compound	nmol,O2
R9965	T38507	T38504	pobj	O2,as
R9966	T38508	T38507	punct	·,O2
R9967	T38509	T38507	appos	ml,O2
R9968	T38510	T38511	punct	−,1
R9969	T38511	T38509	nummod	1,ml
R9970	T38512	T38493	punct	.,taken
R9971	T38514	T38515	compound	Respiration,rates
R9972	T38515	T38516	nsubjpass	rates,expressed
R9973	T38517	T38516	auxpass	were,expressed
R9974	T38518	T38516	prep	as,expressed
R9975	T38519	T38520	compound	nmol,O2
R9976	T38520	T38518	pobj	O2,as
R9977	T38521	T38520	punct	·,O2
R9978	T38522	T38520	appos	min,O2
R9979	T38523	T38524	punct	−,1
R9980	T38524	T38522	nummod	1,min
R9981	T38525	T38520	punct	·,O2
R9982	T38526	T38520	appos	mgdw,O2
R9983	T38527	T38528	punct	−,1
R9984	T38528	T38526	nummod	1,mgdw
R9985	T38529	T38516	punct	.,expressed
R9988	T38945	T38946	nmod	Insulin,tolerance
R9989	T38946	T38949	compound	tolerance,tests
R9990	T38947	T38945	cc	and,Insulin
R9991	T38948	T38945	conj	glucose,Insulin
R9992	T38951	T38952	nmod	Glucose,tolerance
R9993	T38952	T38955	compound	tolerance,tests
R9994	T38953	T38951	cc	and,Glucose
R9995	T38954	T38951	conj	Insulin,Glucose
R9996	T38955	T38956	nsubjpass	tests,performed
R9997	T38957	T38956	auxpass	were,performed
R9998	T38958	T38959	mark	as,described
R9999	T38959	T38956	advcl	described,performed
R10000	T38960	T38961	punct	[,35
R10001	T38961	T38959	parataxis	35,described
R10002	T38962	T38961	punct	],35
R10003	T38963	T38956	punct	.,performed
R10004	T38965	T38966	amod	Prior,to
R10005	T38966	T38967	prep	to,fasted
R10006	T38968	T38966	pobj	studies,to
R10007	T38969	T38967	punct	", ",fasted
R10008	T38970	T38967	nsubjpass	mice,fasted
R10009	T38971	T38967	auxpass	were,fasted
R10010	T38972	T38973	advmod	overnight,h
R10011	T38973	T38967	npadvmod	h,fasted
R10012	T38974	T38975	punct	(,GTT
R10013	T38975	T38972	parataxis	GTT,overnight
R10014	T38976	T38975	punct	),GTT
R10015	T38977	T38973	cc	or,h
R10016	T38978	T38973	nummod	6,h
R10017	T38979	T38980	punct	(,ITT
R10018	T38980	T38973	parataxis	ITT,h
R10019	T38981	T38980	punct	),ITT
R10020	T38982	T38967	punct	.,fasted
R10021	T38984	T38985	prep	In,injected
R10022	T38986	T38987	compound	GTT,studies
R10023	T38987	T38984	pobj	studies,In
R10024	T38988	T38985	punct	", ",injected
R10025	T38989	T38985	nsubjpass	mice,injected
R10026	T38990	T38985	auxpass	were,injected
R10027	T38991	T38985	prep	with,injected
R10028	T38992	T38993	det	a,solution
R10029	T38993	T38991	pobj	solution,with
R10030	T38994	T38995	nummod	10,%
R10031	T38995	T38993	compound	%,solution
R10032	T38996	T38993	prep	of,solution
R10033	T38997	T38998	compound	D,glucose
R10034	T38998	T38996	pobj	glucose,of
R10035	T38999	T38998	punct	-,glucose
R10036	T39000	T39001	punct	(,g
R10037	T39001	T38998	parataxis	g,glucose
R10038	T39002	T39001	nummod	1,g
R10039	T39003	T39004	punct	/,kg
R10040	T39004	T39001	prep	kg,g
R10041	T39005	T39001	punct	),g
R10042	T39006	T38985	punct	.,injected
R10043	T39008	T39009	prep	For,received
R10044	T39010	T39008	pobj	ITT,For
R10045	T39011	T39009	punct	", ",received
R10046	T39012	T39009	nsubj	mice,received
R10047	T39013	T39014	det	an,injection
R10048	T39014	T39009	dobj	injection,received
R10049	T39015	T39014	compound	IP,injection
R10050	T39016	T39014	prep	of,injection
R10051	T39017	T39018	amod	human,insulin
R10052	T39018	T39016	pobj	insulin,of
R10053	T39019	T39018	amod	regular,insulin
R10054	T39020	T39021	punct	(,Lilly
R10055	T39021	T39014	parataxis	Lilly,injection
R10056	T39022	T39021	compound	Eli,Lilly
R10057	T39023	T39021	punct	", ",Lilly
R10058	T39024	T39021	npadvmod	Indianapolis,Lilly
R10059	T39025	T39021	punct	", ",Lilly
R10060	T39026	T39021	npadvmod	Indiana,Lilly
R10061	T39027	T39021	punct	", ",Lilly
R10062	T39028	T39029	compound	United,States
R10063	T39029	T39021	npadvmod	States,Lilly
R10064	T39030	T39021	punct	),Lilly
R10065	T39031	T39009	prep	at,received
R10066	T39032	T39033	det	a,dose
R10067	T39033	T39031	pobj	dose,at
R10068	T39034	T39033	prep	of,dose
R10069	T39035	T39036	nummod	0.75,units
R10070	T39036	T39034	pobj	units,of
R10071	T39037	T39038	punct	/,kg
R10072	T39038	T39036	prep	kg,units
R10073	T39039	T39038	prep	of,kg
R10074	T39040	T39041	compound	body,weight
R10075	T39041	T39039	pobj	weight,of
R10076	T39042	T39009	punct	.,received
R10077	T39044	T39045	compound	Tail,glucose
R10078	T39045	T39047	nsubjpass	glucose,determined
R10079	T39046	T39045	compound	blood,glucose
R10080	T39048	T39047	auxpass	was,determined
R10081	T39049	T39047	prep	at,determined
R10082	T39050	T39051	nummod	0,min
R10083	T39051	T39049	pobj	min,at
R10084	T39052	T39050	punct	", ",0
R10085	T39053	T39050	conj	30,0
R10086	T39054	T39053	punct	", ",30
R10087	T39055	T39053	conj	60,30
R10088	T39056	T39055	punct	", ",60
R10089	T39057	T39055	cc	and,60
R10090	T39058	T39055	conj	120,60
R10091	T39059	T39051	prep	after,min
R10092	T39060	T39059	pobj	challenge,after
R10093	T39061	T39047	advcl	using,determined
R10094	T39062	T39063	det	a,Analyzer
R10095	T39063	T39061	dobj	Analyzer,using
R10096	T39064	T39065	compound	B,GLUCOSE
R10097	T39065	T39063	compound	GLUCOSE,Analyzer
R10098	T39066	T39065	punct	-,GLUCOSE
R10099	T39067	T39068	punct	(,AB
R10100	T39068	T39061	parataxis	AB,using
R10101	T39069	T39068	compound	Hemacue,AB
R10102	T39070	T39068	punct	", ",AB
R10103	T39071	T39068	npadvmod	Angelholm,AB
R10104	T39072	T39068	punct	", ",AB
R10105	T39073	T39068	npadvmod	Sweden,AB
R10106	T39074	T39068	punct	),AB
R10107	T39075	T39047	punct	.,determined
R10113	T39327	T39323	appos	VO2,rates
R10114	T39328	T39323	punct	),rates
R10115	T39329	T39323	prep	of,rates
R10116	T39330	T39331	nummod	5,wk
R10117	T39331	T39333	npadvmod	wk,old
R10118	T39332	T39331	punct	-,wk
R10119	T39333	T39335	amod	old,mice
R10120	T39334	T39333	punct	-,old
R10121	T39335	T39329	pobj	mice,of
R10122	T39336	T39335	amod	female,mice
R10123	T39337	T39325	auxpass	were,measured
R10124	T39338	T39325	advcl	using,measured
R10125	T39339	T39340	det	a,System
R10126	T39340	T39338	dobj	System,using
R10127	T39341	T39342	compound	Columbus,Instruments
R10128	T39342	T39340	compound	Instruments,System
R10129	T39343	T39340	compound	Oxymax,System
R10130	T39344	T39325	punct	.,measured
R10131	T39346	T39347	compound	Resting,rates
R10132	T39347	T39351	nsubjpass	rates,assessed
R10133	T39348	T39347	compound	baseline,rates
R10134	T39349	T39350	compound	oxygen,consumption
R10135	T39350	T39347	compound	consumption,rates
R10136	T39352	T39351	auxpass	were,assessed
R10137	T39353	T39351	prep	for,assessed
R10138	T39354	T39355	advmod	at,least
R10139	T39355	T39356	advmod	least,1.0
R10140	T39356	T39357	nummod	1.0,h
R10141	T39357	T39353	pobj	h,for
R10142	T39358	T39351	punct	.,assessed
R10143	T39360	T39361	prep	For,dissolved
R10144	T39362	T39363	npadvmod	β3,adrenergic
R10145	T39363	T39365	amod	adrenergic,studies
R10146	T39364	T39363	punct	-,adrenergic
R10147	T39365	T39360	pobj	studies,For
R10148	T39366	T39365	compound	stimulation,studies
R10149	T39367	T39361	punct	", ",dissolved
R10150	T39368	T39361	nsubjpass	BRL,dissolved
R10151	T39369	T39368	nummod	37344,BRL
R10152	T39370	T39371	punct	(,Sigma
R10153	T39371	T39368	parataxis	Sigma,BRL
R10154	T39372	T39371	punct	),Sigma
R10155	T39373	T39361	auxpass	was,dissolved
R10156	T39374	T39361	prep	in,dissolved
R10157	T39375	T39376	amod	sterile,saline
R10158	T39376	T39374	pobj	saline,in
R10159	T39377	T39361	cc	and,dissolved
R10160	T39378	T39361	conj	injected,dissolved
R10161	T39379	T39378	advmod	IP,injected
R10162	T39380	T39381	punct	(,μg
R10163	T39381	T39378	parataxis	μg,injected
R10164	T39382	T39381	nummod	2,μg
R10165	T39383	T39384	punct	/,g
R10166	T39384	T39381	prep	g,μg
R10167	T39385	T39384	prep	of,g
R10168	T39386	T39387	compound	body,weight
R10169	T39387	T39385	pobj	weight,of
R10170	T39388	T39381	punct	),μg
R10171	T39389	T39390	punct	[,45
R10172	T39390	T39378	parataxis	45,injected
R10173	T39391	T39390	punct	],45
R10174	T39392	T39361	punct	.,dissolved
R10175	T39394	T39395	compound	Postagonist,assessment
R10176	T39395	T39396	nsubjpass	assessment,recorded
R10177	T39397	T39395	prep	of,assessment
R10178	T39398	T39399	compound	oxygen,consumption
R10179	T39399	T39397	pobj	consumption,of
R10180	T39400	T39396	auxpass	was,recorded
R10181	T39401	T39396	prep	for,recorded
R10182	T39402	T39403	det	an,h
R10183	T39403	T39401	pobj	h,for
R10184	T39404	T39403	amod	additional,h
R10185	T39405	T39403	nummod	1.0,h
R10186	T39406	T39396	punct	", ",recorded
R10187	T39407	T39396	prep	with,recorded
R10188	T39408	T39407	pobj	data,with
R10189	T39409	T39408	acl	collected,data
R10190	T39410	T39409	prep	at,collected
R10191	T39411	T39412	det	the,point
R10192	T39412	T39410	pobj	point,at
R10193	T39413	T39414	nummod	40,min
R10194	T39414	T39412	compound	min,point
R10195	T39415	T39414	punct	-,min
R10196	T39416	T39412	compound	time,point
R10197	T39417	T39396	punct	.,recorded
R10200	T40047	T40046	cc	and,Histology
R10201	T40048	T40049	compound	electron,microscopy
R10202	T40049	T40046	conj	microscopy,Histology
R10203	T40051	T40052	compound	Soleus,muscle
R10204	T40052	T40053	nsubjpass	muscle,dissected
R10205	T40054	T40052	cc	and,muscle
R10206	T40055	T40052	conj	liver,muscle
R10207	T40056	T40053	auxpass	were,dissected
R10208	T40057	T40053	cc	and,dissected
R10209	T40058	T40053	conj	fixed,dissected
R10210	T40059	T40058	advmod	overnight,fixed
R10211	T40060	T40058	prep	in,fixed
R10212	T40061	T40062	nummod	2,%
R10213	T40062	T40063	nmod	%,glutaraldehyde
R10214	T40063	T40064	nmod	glutaraldehyde,buffer
R10215	T40064	T40060	pobj	buffer,in
R10216	T40065	T40063	punct	", ",glutaraldehyde
R10217	T40066	T40067	nummod	1,%
R10218	T40067	T40068	compound	%,paraformaldehyde
R10219	T40068	T40063	conj	paraformaldehyde,glutaraldehyde
R10220	T40069	T40068	punct	", ",paraformaldehyde
R10221	T40070	T40068	cc	and,paraformaldehyde
R10222	T40071	T40072	nummod	0.08,%
R10223	T40072	T40068	conj	%,paraformaldehyde
R10224	T40073	T40074	compound	sodium,cacodylate
R10225	T40074	T40072	appos	cacodylate,%
R10226	T40075	T40053	punct	.,dissected
R10227	T40077	T40078	det	The,tissues
R10228	T40078	T40079	nsubjpass	tissues,postfixed
R10229	T40080	T40079	auxpass	were,postfixed
R10230	T40081	T40079	prep	in,postfixed
R10231	T40082	T40083	nummod	1,%
R10232	T40083	T40084	compound	%,tetroxide
R10233	T40084	T40081	pobj	tetroxide,in
R10234	T40085	T40084	compound	osmium,tetroxide
R10235	T40086	T40079	punct	", ",postfixed
R10236	T40087	T40079	conj	dehydrated,postfixed
R10237	T40088	T40087	prep	in,dehydrated
R10238	T40089	T40090	amod	graded,ethanol
R10239	T40090	T40088	pobj	ethanol,in
R10240	T40091	T40087	punct	", ",dehydrated
R10241	T40092	T40087	conj	embedded,dehydrated
R10242	T40093	T40092	prep	in,embedded
R10243	T40094	T40095	compound	Poly,Bed
R10244	T40095	T40096	compound	Bed,resin
R10245	T40096	T40093	pobj	resin,in
R10246	T40097	T40096	compound	plastic,resin
R10247	T40098	T40092	punct	", ",embedded
R10248	T40099	T40092	cc	and,embedded
R10249	T40100	T40092	conj	sectioned,embedded
R10250	T40101	T40100	prep	for,sectioned
R10251	T40102	T40103	compound	electron,microscopy
R10252	T40103	T40101	pobj	microscopy,for
R10253	T40104	T40079	punct	.,postfixed
R10254	T40106	T40107	amod	Cardiac,muscle
R10255	T40107	T40110	nmod	muscle,densities
R10256	T40108	T40106	cc	and,Cardiac
R10257	T40109	T40106	conj	skeletal,Cardiac
R10258	T40110	T40115	nsubjpass	densities,determined
R10259	T40111	T40110	amod	mitochondrial,densities
R10260	T40112	T40111	cc	and,mitochondrial
R10261	T40113	T40111	conj	myofibrillar,mitochondrial
R10262	T40114	T40110	compound	volume,densities
R10263	T40116	T40115	auxpass	were,determined
R10264	T40117	T40115	prep	from,determined
R10265	T40118	T40119	compound	electron,micrographs
R10266	T40119	T40117	pobj	micrographs,from
R10267	T40120	T40121	mark	as,described
R10268	T40121	T40115	advcl	described,determined
R10269	T40122	T40121	advmod	previously,described
R10270	T40123	T40124	punct	[,10
R10271	T40124	T40121	parataxis	10,described
R10272	T40125	T40124	punct	],10
R10273	T40126	T40115	punct	.,determined
R10274	T40128	T40129	prep	For,quantified
R10275	T40130	T40131	det	each,animal
R10276	T40131	T40128	pobj	animal,For
R10277	T40132	T40129	punct	", ",quantified
R10278	T40133	T40134	nummod	three,fields
R10279	T40134	T40129	nsubjpass	fields,quantified
R10280	T40135	T40134	amod	different,fields
R10281	T40136	T40134	prep	at,fields
R10282	T40137	T40138	det	the,magnification
R10283	T40138	T40136	pobj	magnification,at
R10284	T40139	T40138	prep	of,magnification
R10285	T40140	T40139	pobj	7500,of
R10286	T40141	T40140	punct	×,7500
R10287	T40142	T40129	auxpass	were,quantified
R10288	T40143	T40129	prep	in,quantified
R10289	T40144	T40145	amod	blinded,fashion
R10290	T40145	T40143	pobj	fashion,in
R10291	T40146	T40129	punct	.,quantified
R10292	T40148	T40149	nsubjpass	Data,expressed
R10293	T40150	T40149	auxpass	were,expressed
R10294	T40151	T40149	prep	as,expressed
R10295	T40152	T40153	compound	mean,density
R10296	T40153	T40151	pobj	density,as
R10297	T40154	T40153	compound	volume,density
R10298	T40155	T40153	prep	of,density
R10299	T40156	T40155	pobj	mitochondria,of
R10300	T40157	T40156	cc	or,mitochondria
R10301	T40158	T40156	conj	myofibrils,mitochondria
R10302	T40159	T40153	prep	in,density
R10303	T40160	T40161	det	each,field
R10304	T40161	T40159	pobj	field,in
R10305	T40162	T40149	punct	.,expressed
R10306	T40164	T40165	prep	For,prepared
R10307	T40166	T40167	nmod	electron,analysis
R10308	T40167	T40164	pobj	analysis,For
R10309	T40168	T40167	amod	microscopic,analysis
R10310	T40169	T40167	prep	of,analysis
R10311	T40170	T40171	det	the,brain
R10312	T40171	T40169	pobj	brain,of
R10313	T40172	T40165	punct	", ",prepared
R10314	T40173	T40165	nsubjpass	tissue,prepared
R10315	T40174	T40165	auxpass	was,prepared
R10316	T40175	T40176	mark	as,described
R10317	T40176	T40165	advcl	described,prepared
R10318	T40177	T40176	advmod	previously,described
R10319	T40178	T40179	punct	[,46
R10320	T40179	T40176	parataxis	46,described
R10321	T40180	T40179	punct	],46
R10322	T40181	T40165	punct	.,prepared
R10323	T40183	T40184	amod	Ultrathin,sections
R10324	T40184	T40185	nsubjpass	sections,cut
R10325	T40186	T40184	prep	of,sections
R10326	T40187	T40186	pobj	cortex,of
R10327	T40188	T40185	auxpass	were,cut
R10328	T40189	T40185	prep	onto,cut
R10329	T40190	T40191	npadvmod	formvar,coated
R10330	T40191	T40193	amod	coated,grids
R10331	T40192	T40191	punct	-,coated
R10332	T40193	T40189	pobj	grids,onto
R10333	T40194	T40193	compound	slot,grids
R10334	T40195	T40193	acl	stained,grids
R10335	T40196	T40195	prep	with,stained
R10336	T40197	T40198	compound	uranyl,acetate
R10337	T40198	T40196	pobj	acetate,with
R10338	T40199	T40198	cc	and,acetate
R10339	T40200	T40201	compound	lead,citrate
R10340	T40201	T40198	conj	citrate,acetate
R10341	T40202	T40185	cc	and,cut
R10342	T40203	T40185	conj	examined,cut
R10343	T40204	T40203	prep	with,examined
R10344	T40205	T40206	det	a,microscope
R10345	T40206	T40204	pobj	microscope,with
R10346	T40207	T40206	nmod	JEOL,microscope
R10347	T40208	T40207	nummod	1200,JEOL
R10348	T40209	T40206	compound	electron,microscope
R10349	T40210	T40185	punct	.,cut
R10350	T40212	T40213	prep	For,dehydrated
R10351	T40214	T40215	nmod	H,staining
R10352	T40215	T40212	pobj	staining,For
R10353	T40216	T40214	cc	&,H
R10354	T40217	T40214	conj	E,H
R10355	T40218	T40213	punct	", ",dehydrated
R10356	T40219	T40213	nsubjpass	sections,dehydrated
R10357	T40220	T40219	prep	of,sections
R10358	T40221	T40220	pobj	brain,of
R10359	T40222	T40219	punct	", ",sections
R10360	T40223	T40219	prep	including,sections
R10361	T40224	T40225	amod	cerebral,cortex
R10362	T40225	T40223	pobj	cortex,including
R10363	T40226	T40225	punct	", ",cortex
R10364	T40227	T40225	conj	brainstem,cortex
R10365	T40228	T40227	punct	", ",brainstem
R10366	T40229	T40227	cc	and,brainstem
R10367	T40230	T40227	conj	cerebellum,brainstem
R10368	T40231	T40213	punct	", ",dehydrated
R10369	T40232	T40213	auxpass	were,dehydrated
R10370	T40233	T40213	prep	in,dehydrated
R10371	T40234	T40235	amod	graded,concentrations
R10372	T40235	T40233	pobj	concentrations,in
R10373	T40236	T40235	prep	of,concentrations
R10374	T40237	T40236	pobj	alcohol,of
R10375	T40238	T40213	cc	and,dehydrated
R10376	T40239	T40213	conj	embedded,dehydrated
R10377	T40240	T40239	prep	in,embedded
R10378	T40241	T40240	pobj	paraffin,in
R10379	T40242	T40243	prep	from,prepared
R10380	T40243	T40241	relcl	prepared,paraffin
R10381	T40244	T40242	pobj	which,from
R10382	T40245	T40246	nummod	5,μm
R10383	T40246	T40248	compound	μm,sections
R10384	T40247	T40246	punct	-,μm
R10385	T40248	T40243	nsubjpass	sections,prepared
R10386	T40249	T40243	auxpass	were,prepared
R10387	T40250	T40213	punct	.,dehydrated
R10388	T40760	T40761	amod	Primary,studies
R10389	T40762	T40763	compound	mouse,hepatocyte
R10390	T40763	T40761	compound	hepatocyte,studies
R10391	T40765	T40766	amod	Primary,cultures
R10392	T40766	T40767	nsubjpass	cultures,prepared
R10393	T40768	T40766	prep	of,cultures
R10394	T40769	T40770	compound	mouse,hepatocytes
R10395	T40770	T40768	pobj	hepatocytes,of
R10396	T40771	T40767	auxpass	were,prepared
R10397	T40772	T40767	prep	from,prepared
R10398	T40773	T40774	amod	male,mice
R10399	T40774	T40772	pobj	mice,from
R10400	T40775	T40776	nmod	PGC,1α
R10401	T40776	T40774	nmod	1α,mice
R10402	T40777	T40776	punct	-,1α
R10403	T40778	T40776	punct	+,1α
R10404	T40779	T40776	punct	/,1α
R10405	T40780	T40776	punct	+,1α
R10406	T40781	T40776	cc	and,1α
R10407	T40782	T40783	compound	PGC,1α
R10408	T40783	T40776	conj	1α,1α
R10409	T40784	T40783	punct	-,1α
R10410	T40785	T40783	punct	−,1α
R10411	T40786	T40783	punct	/,1α
R10412	T40787	T40783	punct	−,1α
R10413	T40788	T40789	advmod	essentially,described
R10414	T40789	T40767	advcl	described,prepared
R10415	T40790	T40789	mark	as,described
R10416	T40791	T40792	punct	[,47
R10417	T40792	T40789	parataxis	47,described
R10418	T40793	T40792	punct	],47
R10419	T40794	T40767	punct	.,prepared
R10420	T40796	T40797	amod	Fatty,acid
R10421	T40797	T40798	nmod	acid,oxidation
R10422	T40798	T40799	nmod	oxidation,experiments
R10423	T40799	T40803	nsubjpass	experiments,commenced
R10424	T40800	T40798	cc	and,oxidation
R10425	T40801	T40802	compound	triglyceride,synthesis
R10426	T40802	T40798	conj	synthesis,oxidation
R10427	T40804	T40803	auxpass	were,commenced
R10428	T40805	T40806	quantmod	2,3
R10429	T40806	T40808	nummod	3,h
R10430	T40807	T40806	punct	–,3
R10431	T40808	T40809	npadvmod	h,plated
R10432	T40809	T40803	advcl	plated,commenced
R10433	T40810	T40809	mark	after,plated
R10434	T40811	T40812	det	the,cells
R10435	T40812	T40809	nsubjpass	cells,plated
R10436	T40813	T40809	auxpass	were,plated
R10437	T40814	T40803	punct	.,commenced
R10438	T40816	T40817	compound	Triglyceride,synthesis
R10439	T40817	T40818	compound	synthesis,studies
R10440	T40818	T40819	nsubjpass	studies,performed
R10441	T40820	T40819	punct	", ",performed
R10442	T40821	T40819	auxpass	were,performed
R10443	T40822	T40823	mark	as,described
R10444	T40823	T40819	advcl	described,performed
R10445	T40824	T40823	advmod	previously,described
R10446	T40825	T40826	punct	[,47
R10447	T40826	T40823	parataxis	47,described
R10448	T40827	T40826	punct	],47
R10449	T40828	T40819	punct	.,performed
R10450	T40830	T40831	compound	Palmitate,rates
R10451	T40831	T40833	nsubjpass	rates,quantified
R10452	T40832	T40831	compound	oxidation,rates
R10453	T40834	T40833	auxpass	were,quantified
R10454	T40835	T40833	advcl	using,quantified
R10455	T40836	T40835	punct	[,using
R10456	T40837	T40838	nummod	9,3H
R10457	T40838	T40842	npadvmod	3H,palmitic
R10458	T40839	T40838	punct	",",3H
R10459	T40840	T40838	nummod	10,3H
R10460	T40841	T40838	punct	-,3H
R10461	T40842	T40845	amod	palmitic,acid
R10462	T40843	T40842	punct	],palmitic
R10463	T40844	T40842	punct	-,palmitic
R10464	T40845	T40835	dobj	acid,using
R10465	T40846	T40847	mark	as,described
R10466	T40847	T40835	advcl	described,using
R10467	T40848	T40849	punct	[,48
R10468	T40849	T40847	parataxis	48,described
R10469	T40850	T40849	punct	],48
R10470	T40851	T40833	cc	and,quantified
R10471	T40852	T40833	conj	corrected,quantified
R10472	T40853	T40852	prep	for,corrected
R10473	T40854	T40855	amod	total,content
R10474	T40855	T40853	pobj	content,for
R10475	T40856	T40855	amod	cellular,content
R10476	T40857	T40855	compound	protein,content
R10477	T40858	T40833	punct	.,quantified
R10478	T40860	T40861	prep	For,spun
R10479	T40862	T40863	compound	respiration,studies
R10480	T40863	T40860	pobj	studies,For
R10481	T40864	T40861	punct	", ",spun
R10482	T40865	T40861	nsubjpass	cells,spun
R10483	T40866	T40861	auxpass	were,spun
R10484	T40867	T40861	prt	down,spun
R10485	T40868	T40869	amod	prior,to
R10486	T40869	T40861	prep	to,spun
R10487	T40870	T40869	pobj	plating,to
R10488	T40871	T40861	cc	and,spun
R10489	T40872	T40861	conj	resuspended,spun
R10490	T40873	T40872	prep	in,resuspended
R10491	T40874	T40875	det	a,buffer
R10492	T40875	T40873	pobj	buffer,in
R10493	T40876	T40875	compound	permeabilization,buffer
R10494	T40877	T40875	punct	(,buffer
R10495	T40878	T40875	acl	described,buffer
R10496	T40879	T40878	advmod	above,described
R10497	T40880	T40875	punct	),buffer
R10498	T40881	T40875	acl	containing,buffer
R10499	T40882	T40883	nummod	50,μg
R10500	T40883	T40884	nmod	μg,saponin
R10501	T40884	T40881	dobj	saponin,containing
R10502	T40885	T40886	punct	/,ml
R10503	T40886	T40883	prep	ml,μg
R10504	T40887	T40861	punct	.,spun
R10505	T40889	T40890	compound	Respiration,studies
R10506	T40890	T40891	nsubjpass	studies,performed
R10507	T40892	T40891	auxpass	were,performed
R10508	T40893	T40891	prep	in,performed
R10509	T40894	T40895	det	the,presence
R10510	T40895	T40893	pobj	presence,in
R10511	T40896	T40895	prep	of,presence
R10512	T40897	T40898	nummod	5,mM
R10513	T40898	T40899	compound	mM,succinate
R10514	T40899	T40896	pobj	succinate,of
R10515	T40900	T40891	prep	in,performed
R10516	T40901	T40902	det	the,presence
R10517	T40902	T40900	pobj	presence,in
R10518	T40903	T40902	prep	of,presence
R10519	T40904	T40905	nummod	10,μM
R10520	T40905	T40906	compound	μM,rotenone
R10521	T40906	T40903	pobj	rotenone,of
R10522	T40907	T40891	punct	.,performed
R10523	T40909	T40910	compound	Respiration,rates
R10524	T40910	T40911	nsubjpass	rates,expressed
R10525	T40912	T40911	auxpass	were,expressed
R10526	T40913	T40911	prep	as,expressed
R10527	T40914	T40915	compound	nmol,O2
R10528	T40915	T40913	pobj	O2,as
R10529	T40916	T40915	punct	·,O2
R10530	T40917	T40915	appos	min,O2
R10531	T40918	T40919	punct	−,1
R10532	T40919	T40917	nummod	1,min
R10533	T40920	T40915	punct	·,O2
R10534	T40921	T40915	appos	mg,O2
R10535	T40922	T40921	prep	of,mg
R10536	T40923	T40922	pobj	protein,of
R10537	T40924	T40925	punct	−,1
R10538	T40925	T40921	nummod	1,mg
R10539	T40926	T40911	punct	.,expressed
R10540	T42847	T42846	prep	of,Evaluation
R10541	T42848	T42849	compound	locomotor,activity
R10542	T42849	T42847	pobj	activity,of
R10543	T42850	T42849	punct	", ",activity
R10544	T42851	T42852	compound	sensorimotor,capabilities
R10545	T42852	T42849	conj	capabilities,activity
R10546	T42853	T42852	punct	", ",capabilities
R10547	T42854	T42852	cc	and,capabilities
R10548	T42855	T42856	compound	muscle,function
R10549	T42856	T42852	conj	function,capabilities
R10550	T42858	T42859	aux	To,evaluate
R10551	T42859	T42860	advcl	evaluate,evaluated
R10552	T42861	T42862	amod	general,levels
R10553	T42862	T42859	dobj	levels,evaluate
R10554	T42863	T42862	compound	activity,levels
R10555	T42864	T42862	cc	and,levels
R10556	T42865	T42866	compound	muscle,use
R10557	T42866	T42862	conj	use,levels
R10558	T42867	T42860	punct	", ",evaluated
R10559	T42868	T42860	nsubjpass	mice,evaluated
R10560	T42869	T42860	auxpass	were,evaluated
R10561	T42870	T42860	prep	over,evaluated
R10562	T42871	T42872	det	a,period
R10563	T42872	T42870	pobj	period,over
R10564	T42873	T42874	nummod	1,h
R10565	T42874	T42872	compound	h,period
R10566	T42875	T42874	punct	-,h
R10567	T42876	T42860	prep	in,evaluated
R10568	T42877	T42878	nmod	transparent,polystyrene
R10569	T42878	T42876	pobj	polystyrene,in
R10570	T42879	T42878	punct	(,polystyrene
R10571	T42880	T42881	nummod	47.6,cm
R10572	T42881	T42878	nmod	cm,polystyrene
R10573	T42882	T42883	punct	×,cm
R10574	T42883	T42881	prep	cm,cm
R10575	T42884	T42883	nummod	25.4,cm
R10576	T42885	T42886	punct	×,cm
R10577	T42886	T42881	prep	cm,cm
R10578	T42887	T42886	nummod	20.6,cm
R10579	T42888	T42878	punct	),polystyrene
R10580	T42889	T42878	nmod	enclosures,polystyrene
R10581	T42890	T42891	mark	as,described
R10582	T42891	T42860	advcl	described,evaluated
R10583	T42892	T42891	advmod	previously,described
R10584	T42893	T42894	punct	[,49
R10585	T42894	T42891	parataxis	49,described
R10586	T42895	T42894	punct	],49
R10587	T42896	T42860	advcl	using,evaluated
R10588	T42897	T42898	det	a,system
R10589	T42898	T42896	dobj	system,using
R10590	T42899	T42900	amod	high,resolution
R10591	T42900	T42898	compound	resolution,system
R10592	T42901	T42900	punct	-,resolution
R10593	T42902	T42898	compound	photobeam,system
R10594	T42903	T42904	punct	(,Monitor
R10595	T42904	T42898	parataxis	Monitor,system
R10596	T42905	T42904	compound	Motor,Monitor
R10597	T42906	T42904	punct	", ",Monitor
R10598	T42907	T42908	compound	Hamilton,Kinder
R10599	T42908	T42904	npadvmod	Kinder,Monitor
R10600	T42909	T42908	punct	-,Kinder
R10601	T42910	T42904	punct	", ",Monitor
R10602	T42911	T42904	npadvmod	Poway,Monitor
R10603	T42912	T42904	punct	", ",Monitor
R10604	T42913	T42904	npadvmod	California,Monitor
R10605	T42914	T42904	punct	", ",Monitor
R10606	T42915	T42916	compound	United,States
R10607	T42916	T42904	npadvmod	States,Monitor
R10608	T42917	T42904	punct	),Monitor
R10609	T42918	T42860	punct	.,evaluated
R10610	T42920	T42921	det	Each,enclosure
R10611	T42921	T42922	nsubjpass	enclosure,surrounded
R10612	T42923	T42922	auxpass	was,surrounded
R10613	T42924	T42922	agent	by,surrounded
R10614	T42925	T42926	det	a,frame
R10615	T42926	T42924	pobj	frame,by
R10616	T42927	T42926	acl	containing,frame
R10617	T42928	T42929	det	a,matrix
R10618	T42929	T42927	dobj	matrix,containing
R10619	T42930	T42929	nummod	4,matrix
R10620	T42931	T42932	punct	×,8
R10621	T42932	T42930	prep	8,4
R10622	T42933	T42929	prep	of,matrix
R10623	T42934	T42935	compound	photocell,pairs
R10624	T42935	T42933	pobj	pairs,of
R10625	T42936	T42929	punct	", ",matrix
R10626	T42937	T42938	det	the,output
R10627	T42938	T42939	dep	output,fed
R10628	T42939	T42929	relcl	fed,matrix
R10629	T42940	T42938	prep	of,output
R10630	T42941	T42940	pobj	which,of
R10631	T42942	T42939	auxpass	was,fed
R10632	T42943	T42939	prep	to,fed
R10633	T42944	T42945	det	an,computer
R10634	T42945	T42943	pobj	computer,to
R10635	T42946	T42945	nmod	on,computer
R10636	T42947	T42946	punct	-,on
R10637	T42948	T42946	pobj	line,on
R10638	T42949	T42922	punct	.,surrounded
R10639	T42951	T42952	det	The,software
R10640	T42952	T42954	nsubjpass	software,used
R10641	T42953	T42952	compound	system,software
R10642	T42955	T42956	punct	(,Kinder
R10643	T42956	T42952	parataxis	Kinder,software
R10644	T42957	T42956	compound	Hamilton,Kinder
R10645	T42958	T42956	punct	-,Kinder
R10646	T42959	T42956	punct	),Kinder
R10647	T42960	T42954	auxpass	was,used
R10648	T42961	T42962	aux	to,define
R10649	T42962	T42954	advcl	define,used
R10650	T42963	T42964	det	a,zone
R10651	T42964	T42962	dobj	zone,define
R10652	T42965	T42966	nummod	33,cm
R10653	T42966	T42964	nmod	cm,zone
R10654	T42967	T42968	punct	×,cm
R10655	T42968	T42966	prep	cm,cm
R10656	T42969	T42968	nummod	11,cm
R10657	T42970	T42964	amod	central,zone
R10658	T42971	T42964	cc	and,zone
R10659	T42972	T42973	det	a,zone
R10660	T42973	T42964	conj	zone,zone
R10661	T42974	T42973	amod	peripheral,zone
R10662	T42975	T42974	cc	or,peripheral
R10663	T42976	T42974	conj	surrounding,peripheral
R10664	T42977	T42978	dep	that,was
R10665	T42978	T42973	relcl	was,zone
R10666	T42979	T42980	nummod	5.5,cm
R10667	T42980	T42981	npadvmod	cm,wide
R10668	T42981	T42978	acomp	wide,was
R10669	T42982	T42978	prep	with,was
R10670	T42983	T42984	det	the,sides
R10671	T42984	T42985	nsubj	sides,being
R10672	T42985	T42982	pcomp	being,with
R10673	T42986	T42984	prep	of,sides
R10674	T42987	T42988	det	the,cage
R10675	T42988	T42986	pobj	cage,of
R10676	T42989	T42990	det	the,boundary
R10677	T42990	T42985	attr	boundary,being
R10678	T42991	T42990	amod	outermost,boundary
R10679	T42992	T42954	punct	.,used
R10680	T42994	T42995	det	This,area
R10681	T42995	T42997	nsubj	area,extended
R10682	T42996	T42995	amod	peripheral,area
R10683	T42998	T42997	prep	along,extended
R10684	T42999	T43000	det	the,perimeter
R10685	T43000	T42998	pobj	perimeter,along
R10686	T43001	T43000	amod	entire,perimeter
R10687	T43002	T43000	prep	of,perimeter
R10688	T43003	T43004	det	the,cage
R10689	T43004	T43002	pobj	cage,of
R10690	T43005	T42997	punct	.,extended
R10691	T43007	T43008	nsubj	Variables,included
R10692	T43009	T43010	dep	that,analyzed
R10693	T43010	T43007	relcl	analyzed,Variables
R10694	T43011	T43010	auxpass	were,analyzed
R10695	T43012	T43013	det	the,number
R10696	T43013	T43008	dobj	number,included
R10697	T43014	T43013	amod	total,number
R10698	T43015	T43013	prep	of,number
R10699	T43016	T43015	pobj	ambulations,of
R10700	T43017	T43013	punct	", ",number
R10701	T43018	T43019	advmod	as,as
R10702	T43019	T43013	cc	as,number
R10703	T43020	T43019	advmod	well,as
R10704	T43021	T43022	det	the,number
R10705	T43022	T43013	conj	number,number
R10706	T43023	T43022	prep	of,number
R10707	T43024	T43023	pobj	entries,of
R10708	T43025	T43022	punct	", ",number
R10709	T43026	T43027	det	the,time
R10710	T43027	T43022	conj	time,number
R10711	T43028	T43027	acl	spent,time
R10712	T43029	T43027	punct	", ",time
R10713	T43030	T43027	cc	and,time
R10714	T43031	T43032	det	the,distance
R10715	T43032	T43027	conj	distance,time
R10716	T43033	T43032	acl	traveled,distance
R10717	T43034	T43033	prep	in,traveled
R10718	T43035	T43036	det	the,area
R10719	T43036	T43034	pobj	area,in
R10720	T43037	T43036	compound	center,area
R10721	T43038	T43039	advmod	as,as
R10722	T43039	T43032	cc	as,distance
R10723	T43040	T43039	advmod	well,as
R10724	T43041	T43042	det	the,distance
R10725	T43042	T43032	conj	distance,distance
R10726	T43043	T43042	acl	traveled,distance
R10727	T43044	T43043	prep	in,traveled
R10728	T43045	T43046	det	the,periphery
R10729	T43046	T43044	pobj	periphery,in
R10730	T43047	T43046	acl	surrounding,periphery
R10731	T43048	T43049	det	the,center
R10732	T43049	T43047	dobj	center,surrounding
R10733	T43050	T43008	punct	.,included
R10734	T43052	T43053	det	The,number
R10735	T43053	T43055	nsubjpass	number,recorded
R10736	T43054	T43053	amod	total,number
R10737	T43056	T43053	prep	of,number
R10738	T43057	T43056	pobj	ambulations,of
R10739	T43058	T43057	cc	and,ambulations
R10740	T43059	T43057	conj	rearings,ambulations
R10741	T43060	T43055	auxpass	were,recorded
R10742	T43061	T43055	punct	.,recorded
R10743	T43063	T43064	prep	For,placed
R10744	T43065	T43066	det	the,test
R10745	T43066	T43063	pobj	test,For
R10746	T43067	T43066	amod	inverted,test
R10747	T43068	T43066	compound	screen,test
R10748	T43069	T43064	punct	", ",placed
R10749	T43070	T43064	nsubjpass	mice,placed
R10750	T43071	T43064	auxpass	were,placed
R10751	T43072	T43064	prep	on,placed
R10752	T43073	T43074	det	a,grid
R10753	T43074	T43072	pobj	grid,on
R10754	T43075	T43074	compound	wire,grid
R10755	T43076	T43074	compound	mesh,grid
R10756	T43077	T43078	punct	(,squares
R10757	T43078	T43074	parataxis	squares,grid
R10758	T43079	T43078	nummod	16,squares
R10759	T43080	T43078	prep	per,squares
R10760	T43081	T43082	nummod	10,cm
R10761	T43082	T43080	pobj	cm,per
R10762	T43083	T43078	punct	),squares
R10763	T43084	T43064	cc	and,placed
R10764	T43085	T43086	det	the,screen
R10765	T43086	T43087	nsubjpass	screen,inverted
R10766	T43087	T43064	conj	inverted,placed
R10767	T43088	T43087	auxpass	was,inverted
R10768	T43089	T43087	prep	to,inverted
R10769	T43090	T43091	nummod	180,°
R10770	T43091	T43089	pobj	°,to
R10771	T43092	T43064	punct	.,placed
R10772	T43094	T43095	det	A,score
R10773	T43095	T43097	nsubjpass	score,given
R10774	T43096	T43095	amod	maximum,score
R10775	T43098	T43095	prep	of,score
R10776	T43099	T43100	nummod	60,s
R10777	T43100	T43098	pobj	s,of
R10778	T43101	T43097	auxpass	was,given
R10779	T43102	T43103	mark	if,fall
R10780	T43103	T43097	advcl	fall,given
R10781	T43104	T43105	det	an,animal
R10782	T43105	T43103	nsubj	animal,fall
R10783	T43106	T43103	aux	did,fall
R10784	T43107	T43103	neg	not,fall
R10785	T43108	T43097	punct	.,given
R10786	T43110	T43111	det	The,tests
R10787	T43111	T43112	nsubjpass	tests,designed
R10788	T43113	T43111	acl	included,tests
R10789	T43114	T43113	prep	in,included
R10790	T43115	T43116	det	the,battery
R10791	T43116	T43114	pobj	battery,in
R10792	T43117	T43116	compound	sensorimotor,battery
R10793	T43118	T43119	punct	[,50
R10794	T43119	T43116	parataxis	50,battery
R10795	T43120	T43119	punct	],50
R10796	T43121	T43116	cc	and,battery
R10797	T43122	T43123	amod	accompanying,protocols
R10798	T43123	T43116	conj	protocols,battery
R10799	T43124	T43112	auxpass	were,designed
R10800	T43125	T43126	mark	as,follows
R10801	T43126	T43112	advcl	follows,designed
R10802	T43127	T43112	punct	.,designed
R10803	T43129	T43130	punct	(,1
R10804	T43130	T43131	meta	1,placed
R10805	T43132	T43130	punct	),1
R10806	T43133	T43134	amod	Inclined,screen
R10807	T43134	T43135	nmod	screen,tests
R10808	T43135	T43131	dep	tests,placed
R10809	T43136	T43134	cc	and,screen
R10810	T43137	T43138	amod	inverted,screen
R10811	T43138	T43134	conj	screen,screen
R10812	T43139	T43131	punct	: ,placed
R10813	T43140	T43131	prep	For,placed
R10814	T43141	T43142	det	the,tests
R10815	T43142	T43140	pobj	tests,For
R10816	T43143	T43142	amod	inclined,tests
R10817	T43144	T43142	compound	screen,tests
R10818	T43145	T43131	punct	", ",placed
R10819	T43146	T43147	det	each,mouse
R10820	T43147	T43131	nsubjpass	mouse,placed
R10821	T43148	T43131	auxpass	was,placed
R10822	T43149	T43131	prep	on,placed
R10823	T43150	T43149	pobj	top,on
R10824	T43151	T43150	prep	of,top
R10825	T43152	T43153	det	an,grid
R10826	T43153	T43151	pobj	grid,of
R10827	T43154	T43153	amod	elevated,grid
R10828	T43155	T43156	punct	(,above
R10829	T43156	T43154	parataxis	above,elevated
R10830	T43157	T43158	nummod	47,cm
R10831	T43158	T43156	npadvmod	cm,above
R10832	T43159	T43160	det	the,floor
R10833	T43160	T43156	pobj	floor,above
R10834	T43161	T43156	punct	),above
R10835	T43162	T43163	compound	wire,mesh
R10836	T43163	T43153	compound	mesh,grid
R10837	T43164	T43165	punct	(,squares
R10838	T43165	T43153	parataxis	squares,grid
R10839	T43166	T43165	nummod	16,squares
R10840	T43167	T43165	prep	per,squares
R10841	T43168	T43169	nummod	10,cm
R10842	T43169	T43167	pobj	cm,per
R10843	T43170	T43165	punct	),squares
R10844	T43171	T43172	dep	that,inclined
R10845	T43172	T43153	relcl	inclined,grid
R10846	T43173	T43172	auxpass	was,inclined
R10847	T43174	T43172	prep	to,inclined
R10848	T43175	T43176	nummod	60,°
R10849	T43176	T43174	pobj	°,to
R10850	T43177	T43176	cc	or,°
R10851	T43178	T43179	nummod	90,°
R10852	T43179	T43176	conj	°,°
R10853	T43180	T43131	punct	.,placed
R10854	T43182	T43183	det	Each,animal
R10855	T43183	T43184	nsubjpass	animal,placed
R10856	T43185	T43184	auxpass	was,placed
R10857	T43186	T43184	prep	in,placed
R10858	T43187	T43188	det	the,middle
R10859	T43188	T43186	pobj	middle,in
R10860	T43189	T43188	prep	of,middle
R10861	T43190	T43191	det	the,screen
R10862	T43191	T43189	pobj	screen,of
R10863	T43192	T43193	mark	with,oriented
R10864	T43193	T43184	advcl	oriented,placed
R10865	T43194	T43195	poss	its,head
R10866	T43195	T43193	nsubj	head,oriented
R10867	T43196	T43193	advmod	down,oriented
R10868	T43197	T43184	cc	and,placed
R10869	T43198	T43199	auxpass	was,timed
R10870	T43199	T43184	conj	timed,placed
R10871	T43200	T43199	prep	for,timed
R10872	T43201	T43202	advmod	how,long
R10873	T43202	T43203	advmod	long,remained
R10874	T43203	T43200	pobj	remained,for
R10875	T43204	T43203	nsubj	it,remained
R10876	T43205	T43203	prep	on,remained
R10877	T43206	T43207	det	the,screen
R10878	T43207	T43205	pobj	screen,on
R10879	T43208	T43203	cc	and,remained
R10880	T43209	T43210	advmod	how,long
R10881	T43210	T43211	advmod	long,took
R10882	T43211	T43203	conj	took,remained
R10883	T43212	T43211	nsubj	it,took
R10884	T43213	T43214	aux	to,climb
R10885	T43214	T43211	advcl	climb,took
R10886	T43215	T43214	prep	to,climb
R10887	T43216	T43217	det	the,top
R10888	T43217	T43215	pobj	top,to
R10889	T43218	T43217	prep	of,top
R10890	T43219	T43220	det	the,screen
R10891	T43220	T43218	pobj	screen,of
R10892	T43221	T43184	punct	.,placed
R10893	T43223	T43224	prep	For,placed
R10894	T43225	T43226	det	the,test
R10895	T43226	T43223	pobj	test,For
R10896	T43227	T43226	amod	inverted,test
R10897	T43228	T43226	compound	screen,test
R10898	T43229	T43224	punct	", ",placed
R10899	T43230	T43224	nsubjpass	mice,placed
R10900	T43231	T43224	auxpass	were,placed
R10901	T43232	T43224	prep	as,placed
R10902	T43233	T43232	pcomp	above,as
R10903	T43234	T43224	cc	and,placed
R10904	T43235	T43236	advmod	then,inverted
R10905	T43236	T43224	conj	inverted,placed
R10906	T43237	T43238	det	the,screen
R10907	T43238	T43236	nsubjpass	screen,inverted
R10908	T43239	T43236	auxpass	was,inverted
R10909	T43240	T43236	prep	to,inverted
R10910	T43241	T43242	nummod	180,°
R10911	T43242	T43240	pobj	°,to
R10912	T43243	T43236	punct	.,inverted
R10913	T43245	T43246	det	A,score
R10914	T43246	T43248	nsubjpass	score,given
R10915	T43247	T43246	amod	maximum,score
R10916	T43249	T43246	prep	of,score
R10917	T43250	T43251	nummod	60,s
R10918	T43251	T43249	pobj	s,of
R10919	T43252	T43248	auxpass	was,given
R10920	T43253	T43254	mark	if,fall
R10921	T43254	T43248	advcl	fall,given
R10922	T43255	T43256	det	an,animal
R10923	T43256	T43254	nsubj	animal,fall
R10924	T43257	T43254	aux	did,fall
R10925	T43258	T43254	neg	not,fall
R10926	T43259	T43248	punct	;,given
R10927	T43261	T43262	punct	(,2
R10928	T43262	T43263	meta	2,timed
R10929	T43264	T43262	punct	),2
R10930	T43265	T43266	compound	Platform,test
R10931	T43266	T43263	dep	test,timed
R10932	T43267	T43263	punct	: ,timed
R10933	T43268	T43269	det	Each,mouse
R10934	T43269	T43263	nsubjpass	mouse,timed
R10935	T43270	T43263	auxpass	was,timed
R10936	T43271	T43263	prep	for,timed
R10937	T43272	T43273	advmod	how,long
R10938	T43273	T43274	advmod	long,remained
R10939	T43274	T43271	pcomp	remained,for
R10940	T43275	T43274	nsubj	it,remained
R10941	T43276	T43274	prep	on,remained
R10942	T43277	T43278	det	an,platform
R10943	T43278	T43276	pobj	platform,on
R10944	T43279	T43278	amod	elevated,platform
R10945	T43280	T43281	punct	(,above
R10946	T43281	T43279	parataxis	above,elevated
R10947	T43282	T43283	nummod	47,cm
R10948	T43283	T43281	npadvmod	cm,above
R10949	T43284	T43285	det	the,floor
R10950	T43285	T43281	pobj	floor,above
R10951	T43286	T43281	punct	),above
R10952	T43287	T43278	amod	circular,platform
R10953	T43288	T43289	punct	(,thick
R10954	T43289	T43278	parataxis	thick,platform
R10955	T43290	T43291	nummod	1.0,cm
R10956	T43291	T43289	npadvmod	cm,thick
R10957	T43292	T43289	cc	and,thick
R10958	T43293	T43294	nummod	3.0,cm
R10959	T43294	T43289	conj	cm,thick
R10960	T43295	T43294	prep	in,cm
R10961	T43296	T43295	pobj	diameter,in
R10962	T43297	T43289	punct	),thick
R10963	T43298	T43263	punct	.,timed
R10964	T43300	T43301	det	A,score
R10965	T43301	T43303	nsubjpass	score,assigned
R10966	T43302	T43301	amod	maximum,score
R10967	T43304	T43301	prep	of,score
R10968	T43305	T43306	nummod	60,s
R10969	T43306	T43304	pobj	s,of
R10970	T43307	T43303	auxpass	was,assigned
R10971	T43308	T43309	mark	if,remained
R10972	T43309	T43303	advcl	remained,assigned
R10973	T43310	T43311	det	the,mouse
R10974	T43311	T43309	nsubj	mouse,remained
R10975	T43312	T43309	prep	on,remained
R10976	T43313	T43314	det	the,platform
R10977	T43314	T43312	pobj	platform,on
R10978	T43315	T43309	prep	for,remained
R10979	T43316	T43317	det	the,amount
R10980	T43317	T43315	pobj	amount,for
R10981	T43318	T43317	compound	maximum,amount
R10982	T43319	T43317	prep	of,amount
R10983	T43320	T43319	pobj	time,of
R10984	T43321	T43309	cc	or,remained
R10985	T43322	T43323	mark	if,climb
R10986	T43323	T43309	conj	climb,remained
R10987	T43324	T43323	nsubj	it,climb
R10988	T43325	T43323	aux	could,climb
R10989	T43326	T43323	advmod	down,climb
R10990	T43327	T43323	prep	on,climb
R10991	T43328	T43329	det	a,pole
R10992	T43329	T43327	pobj	pole,on
R10993	T43330	T43331	advmod	very,thin
R10994	T43331	T43329	amod	thin,pole
R10995	T43332	T43333	dep	that,supported
R10996	T43333	T43329	relcl	supported,pole
R10997	T43334	T43335	det	the,platform
R10998	T43335	T43333	dobj	platform,supported
R10999	T43336	T43323	punct	", ",climb
R11000	T43337	T43323	prep	without,climb
R11001	T43338	T43337	pcomp	falling,without
R11002	T43339	T43303	punct	;,assigned
R11003	T43341	T43342	punct	(,3
R11004	T43342	T43343	meta	3,timed
R11005	T43344	T43342	punct	),3
R11006	T43345	T43346	compound	Ledge,test
R11007	T43346	T43343	dep	test,timed
R11008	T43347	T43343	punct	: ,timed
R11009	T43348	T43349	det	Each,mouse
R11010	T43349	T43343	nsubjpass	mouse,timed
R11011	T43350	T43343	auxpass	was,timed
R11012	T43351	T43343	prep	for,timed
R11013	T43352	T43353	advmod	how,long
R11014	T43353	T43354	advmod	long,maintain
R11015	T43354	T43351	pcomp	maintain,for
R11016	T43355	T43354	nsubj	it,maintain
R11017	T43356	T43354	aux	could,maintain
R11018	T43357	T43358	poss	its,balance
R11019	T43358	T43354	dobj	balance,maintain
R11020	T43359	T43354	prep	on,maintain
R11021	T43360	T43361	det	a,ledge
R11022	T43361	T43359	pobj	ledge,on
R11023	T43362	T43363	nummod	0.75,cm
R11024	T43363	T43365	npadvmod	cm,wide
R11025	T43364	T43363	punct	-,cm
R11026	T43365	T43361	amod	wide,ledge
R11027	T43366	T43361	compound	Plexiglas,ledge
R11028	T43367	T43354	prep	without,maintain
R11029	T43368	T43367	pcomp	falling,without
R11030	T43369	T43370	punct	(,maximum
R11031	T43370	T43354	parataxis	maximum,maintain
R11032	T43371	T43372	nummod	60,s
R11033	T43372	T43370	compound	s,maximum
R11034	T43373	T43370	punct	),maximum
R11035	T43374	T43343	punct	.,timed
R11036	T43376	T43377	det	A,score
R11037	T43377	T43378	nsubjpass	score,assigned
R11038	T43379	T43377	prep	of,score
R11039	T43380	T43381	nummod	60,s
R11040	T43381	T43379	pobj	s,of
R11041	T43382	T43378	auxpass	was,assigned
R11042	T43383	T43378	advmod	also,assigned
R11043	T43384	T43385	mark	if,traversed
R11044	T43385	T43378	advcl	traversed,assigned
R11045	T43386	T43387	det	the,mouse
R11046	T43387	T43385	nsubj	mouse,traversed
R11047	T43388	T43389	det	the,length
R11048	T43389	T43385	dobj	length,traversed
R11049	T43390	T43389	amod	entire,length
R11050	T43391	T43389	punct	(,length
R11051	T43392	T43393	nummod	51,cm
R11052	T43393	T43389	appos	cm,length
R11053	T43394	T43389	punct	),length
R11054	T43395	T43389	prep	of,length
R11055	T43396	T43397	det	the,ledge
R11056	T43397	T43395	pobj	ledge,of
R11057	T43398	T43397	compound	Plexiglas,ledge
R11058	T43399	T43385	cc	and,traversed
R11059	T43400	T43385	conj	returned,traversed
R11060	T43401	T43400	prep	to,returned
R11061	T43402	T43403	det	the,place
R11062	T43403	T43401	pobj	place,to
R11063	T43404	T43403	compound	starting,place
R11064	T43405	T43400	prep	in,returned
R11065	T43406	T43407	amod	less,60
R11066	T43407	T43409	nummod	60,s
R11067	T43408	T43407	quantmod	than,60
R11068	T43409	T43405	pobj	s,in
R11069	T43410	T43400	prep	without,returned
R11070	T43411	T43410	pcomp	falling,without
R11071	T43412	T43378	punct	;,assigned
R11072	T43414	T43415	punct	(,4
R11073	T43415	T43416	meta	4,test
R11074	T43417	T43415	punct	),4
R11075	T43418	T43416	compound	Walking,test
R11076	T43419	T43416	compound	initiation,test
R11077	T43420	T43416	punct	: ,test
R11078	T43421	T43422	det	Each,mouse
R11079	T43422	T43423	nsubjpass	mouse,placed
R11080	T43423	T43416	conj	placed,test
R11081	T43424	T43423	auxpass	was,placed
R11082	T43425	T43423	prep	in,placed
R11083	T43426	T43427	det	the,middle
R11084	T43427	T43425	pobj	middle,in
R11085	T43428	T43427	prep	of,middle
R11086	T43429	T43430	det	a,square
R11087	T43430	T43428	pobj	square,of
R11088	T43431	T43430	acl	outlined,square
R11089	T43432	T43431	agent	by,outlined
R11090	T43433	T43434	amod	white,tape
R11091	T43434	T43432	pobj	tape,by
R11092	T43435	T43434	compound	cloth,tape
R11093	T43436	T43437	punct	(,cm
R11094	T43437	T43434	parataxis	cm,tape
R11095	T43438	T43437	nummod	21,cm
R11096	T43439	T43440	punct	×,cm
R11097	T43440	T43437	prep	cm,cm
R11098	T43441	T43440	nummod	21,cm
R11099	T43442	T43437	punct	),cm
R11100	T43443	T43423	prep	on,placed
R11101	T43444	T43445	det	a,surface
R11102	T43445	T43443	pobj	surface,on
R11103	T43446	T43445	amod	smooth,surface
R11104	T43447	T43445	amod	black,surface
R11105	T43448	T43445	prep	of,surface
R11106	T43449	T43450	det	a,tabletop
R11107	T43450	T43448	pobj	tabletop,of
R11108	T43451	T43450	amod	large,tabletop
R11109	T43452	T43423	cc	.,placed
R11110	T43454	T43455	det	The,time
R11111	T43455	T43456	nsubjpass	time,recorded
R11112	T43457	T43458	nsubj	it,took
R11113	T43458	T43455	advcl	took,time
R11114	T43459	T43460	det	each,mouse
R11115	T43460	T43461	nsubj	mouse,leave
R11116	T43461	T43458	ccomp	leave,took
R11117	T43462	T43461	aux	to,leave
R11118	T43463	T43464	det	the,square
R11119	T43464	T43461	dobj	square,leave
R11120	T43465	T43461	punct	(,leave
R11121	T43466	T43461	dep	place,leave
R11122	T43467	T43468	det	all,paws
R11123	T43468	T43466	dobj	paws,place
R11124	T43469	T43468	nummod	four,paws
R11125	T43470	T43466	advmod	outside,place
R11126	T43471	T43470	prep	of,outside
R11127	T43472	T43473	det	the,tape
R11128	T43473	T43471	pobj	tape,of
R11129	T43474	T43456	punct	),recorded
R11130	T43475	T43456	auxpass	was,recorded
R11131	T43476	T43456	punct	.,recorded
R11132	T43478	T43479	det	The,time
R11133	T43479	T43481	nsubj	time,was
R11134	T43480	T43479	amod	maximum,time
R11135	T43482	T43479	acl	allowed,time
R11136	T43483	T43484	nummod	60,s
R11137	T43484	T43481	attr	s,was
R11138	T43485	T43481	punct	.,was
R11139	T43487	T43488	quantmod	6,8
R11140	T43488	T43490	nummod	8,mo
R11141	T43489	T43488	punct	–,8
R11142	T43490	T43492	npadvmod	mo,old
R11143	T43491	T43490	punct	-,mo
R11144	T43492	T43494	amod	old,mice
R11145	T43493	T43492	punct	-,old
R11146	T43494	T43518	nsubjpass	mice,run
R11147	T43495	T43496	nmod	PGC,1α
R11148	T43496	T43494	nmod	1α,mice
R11149	T43497	T43496	punct	-,1α
R11150	T43498	T43496	punct	+,1α
R11151	T43499	T43496	punct	/,1α
R11152	T43500	T43496	punct	+,1α
R11153	T43501	T43502	punct	(,4
R11154	T43502	T43496	parataxis	4,1α
R11155	T43503	T43502	nsubj	n,4
R11156	T43504	T43502	punct	=,4
R11157	T43505	T43502	punct	),4
R11158	T43506	T43496	cc	and,1α
R11159	T43507	T43508	compound	PGC,1α
R11160	T43508	T43496	conj	1α,1α
R11161	T43509	T43508	punct	-,1α
R11162	T43510	T43508	punct	−,1α
R11163	T43511	T43508	punct	/,1α
R11164	T43512	T43508	punct	−,1α
R11165	T43513	T43514	punct	(,8
R11166	T43514	T43508	parataxis	8,1α
R11167	T43515	T43514	nsubj	n,8
R11168	T43516	T43514	punct	=,8
R11169	T43517	T43514	punct	),8
R11170	T43519	T43518	auxpass	were,run
R11171	T43520	T43518	prep	to,run
R11172	T43521	T43520	pobj	exhaustion,to
R11173	T43522	T43518	advcl	employing,run
R11174	T43523	T43524	det	a,system
R11175	T43524	T43522	dobj	system,employing
R11176	T43525	T43524	amod	motorized,system
R11177	T43526	T43524	punct	", ",system
R11178	T43527	T43528	npadvmod	speed,controlled
R11179	T43528	T43524	amod	controlled,system
R11180	T43529	T43524	punct	", ",system
R11181	T43530	T43524	amod	modular,system
R11182	T43531	T43524	compound	treadmill,system
R11183	T43532	T43533	punct	(,Instruments
R11184	T43533	T43524	parataxis	Instruments,system
R11185	T43534	T43533	compound	Columbus,Instruments
R11186	T43535	T43533	punct	),Instruments
R11187	T43536	T43518	punct	.,run
R11188	T43538	T43539	det	The,treadmill
R11189	T43539	T43540	nsubjpass	treadmill,equipped
R11190	T43541	T43540	auxpass	was,equipped
R11191	T43542	T43540	prep	with,equipped
R11192	T43543	T43544	det	an,stimulus
R11193	T43544	T43542	pobj	stimulus,with
R11194	T43545	T43546	amod	electric,shock
R11195	T43546	T43544	compound	shock,stimulus
R11196	T43547	T43544	cc	and,stimulus
R11197	T43548	T43549	det	an,angle
R11198	T43549	T43544	conj	angle,stimulus
R11199	T43550	T43549	amod	adjustable,angle
R11200	T43551	T43549	compound	inclination,angle
R11201	T43552	T43540	punct	.,equipped
R11202	T43554	T43555	compound	Running,velocity
R11203	T43555	T43556	nsubjpass	velocity,set
R11204	T43557	T43556	auxpass	was,set
R11205	T43558	T43556	prep	at,set
R11206	T43559	T43560	nummod	35,m
R11207	T43560	T43558	pobj	m,at
R11208	T43561	T43562	punct	/,min
R11209	T43562	T43560	prep	min,m
R11210	T43563	T43556	punct	", ",set
R11211	T43564	T43556	prep	with,set
R11212	T43565	T43566	det	a,angle
R11213	T43566	T43564	pobj	angle,with
R11214	T43567	T43566	compound	level,angle
R11215	T43568	T43566	compound	inclination,angle
R11216	T43569	T43556	punct	.,set
R11217	T44022	T44023	compound	VO2max,studies
R11218	T44025	T44026	nsubjpass	VO2max,determined
R11219	T44027	T44026	auxpass	was,determined
R11220	T44028	T44029	mark	while,running
R11221	T44029	T44026	advcl	running,determined
R11222	T44030	T44031	det	the,mice
R11223	T44031	T44029	nsubj	mice,running
R11224	T44032	T44029	aux	were,running
R11225	T44033	T44029	prep	on,running
R11226	T44034	T44035	det	a,treadmill
R11227	T44035	T44033	pobj	treadmill,on
R11228	T44036	T44026	advcl	using,determined
R11229	T44037	T44038	det	an,system
R11230	T44038	T44036	dobj	system,using
R11231	T44039	T44040	amod	open,flow
R11232	T44040	T44038	compound	flow,system
R11233	T44041	T44042	punct	(,System
R11234	T44042	T44038	parataxis	System,system
R11235	T44043	T44042	compound	Columbus,System
R11236	T44044	T44042	compound	Instruments,System
R11237	T44045	T44042	compound	Oxymax,System
R11238	T44046	T44042	punct	),System
R11239	T44047	T44026	punct	.,determined
R11240	T44049	T44050	det	All,measurements
R11241	T44050	T44051	nsubj	measurements,took
R11242	T44052	T44050	prep	of,measurements
R11243	T44053	T44054	compound	oxygen,consumption
R11244	T44054	T44052	pobj	consumption,of
R11245	T44055	T44051	dobj	place,took
R11246	T44056	T44051	prep	at,took
R11247	T44057	T44058	det	an,elevation
R11248	T44058	T44056	pobj	elevation,at
R11249	T44059	T44058	prep	of,elevation
R11250	T44060	T44061	nummod	150,m
R11251	T44061	T44059	pobj	m,of
R11252	T44062	T44063	punct	(,torr
R11253	T44063	T44051	parataxis	torr,took
R11254	T44064	T44065	compound	ambient,PBAR
R11255	T44065	T44063	nsubj	PBAR,torr
R11256	T44066	T44063	punct	=,torr
R11257	T44067	T44063	nummod	745,torr
R11258	T44068	T44063	punct	),torr
R11259	T44069	T44051	punct	.,took
R11260	T44071	T44072	nsubjpass	Animals,placed
R11261	T44073	T44072	auxpass	were,placed
R11262	T44074	T44072	prep	into,placed
R11263	T44075	T44076	det	the,chamber
R11264	T44076	T44074	pobj	chamber,into
R11265	T44077	T44076	amod	metabolic,chamber
R11266	T44078	T44072	prep	for,placed
R11267	T44079	T44080	quantmod	3,5
R11268	T44080	T44082	nummod	5,min
R11269	T44081	T44080	punct	–,5
R11270	T44082	T44078	pobj	min,for
R11271	T44083	T44084	aux	to,allow
R11272	T44084	T44072	advcl	allow,placed
R11273	T44085	T44086	det	the,system
R11274	T44086	T44084	dobj	system,allow
R11275	T44087	T44088	aux	to,equilibrate
R11276	T44088	T44084	xcomp	equilibrate,allow
R11277	T44089	T44072	punct	.,placed
R11278	T44091	T44092	nsubjpass	Mice,induced
R11279	T44093	T44092	auxpass	were,induced
R11280	T44094	T44092	advmod	then,induced
R11281	T44095	T44096	aux	to,run
R11282	T44096	T44092	xcomp	run,induced
R11283	T44097	T44096	prep	up,run
R11284	T44098	T44099	det	an,incline
R11285	T44099	T44097	pobj	incline,up
R11286	T44100	T44101	nummod	18,°
R11287	T44101	T44099	compound	°,incline
R11288	T44102	T44096	prep	at,run
R11289	T44103	T44104	det	a,speed
R11290	T44104	T44102	pobj	speed,at
R11291	T44105	T44104	prep	of,speed
R11292	T44106	T44107	nummod	40,m
R11293	T44107	T44105	pobj	m,of
R11294	T44108	T44109	punct	/,min
R11295	T44109	T44107	prep	min,m
R11296	T44110	T44096	advcl	using,run
R11297	T44111	T44112	det	a,grid
R11298	T44112	T44110	dobj	grid,using
R11299	T44113	T44112	compound	shock,grid
R11300	T44114	T44112	prep	in,grid
R11301	T44115	T44116	det	the,rear
R11302	T44116	T44114	pobj	rear,in
R11303	T44117	T44116	prep	of,rear
R11304	T44118	T44119	det	the,chamber
R11305	T44119	T44117	pobj	chamber,of
R11306	T44120	T44092	punct	.,induced
R11307	T44122	T44123	det	The,speed
R11308	T44123	T44124	nsubjpass	speed,increased
R11309	T44125	T44124	auxpass	was,increased
R11310	T44126	T44124	prep	by,increased
R11311	T44127	T44128	nummod	5,m
R11312	T44128	T44126	pobj	m,by
R11313	T44129	T44130	punct	/,min
R11314	T44130	T44128	prep	min,m
R11315	T44131	T44132	det	every,min
R11316	T44132	T44124	npadvmod	min,increased
R11317	T44133	T44132	nummod	2,min
R11318	T44134	T44135	mark	until,were
R11319	T44135	T44124	advcl	were,increased
R11320	T44136	T44137	det	the,animals
R11321	T44137	T44135	nsubj	animals,were
R11322	T44138	T44135	acomp	unable,were
R11323	T44139	T44140	aux	to,continue
R11324	T44140	T44138	xcomp	continue,unable
R11325	T44141	T44124	punct	.,increased
R11326	T44143	T44144	amod	Maximal,effort
R11327	T44144	T44145	nsubjpass	effort,determined
R11328	T44146	T44145	auxpass	was,determined
R11329	T44147	T44148	advmod	when,increase
R11330	T44148	T44145	advcl	increase,determined
R11331	T44149	T44150	compound	oxygen,uptake
R11332	T44150	T44148	nsubj	uptake,increase
R11333	T44151	T44148	aux	did,increase
R11334	T44152	T44148	neg	not,increase
R11335	T44153	T44148	prep	with,increase
R11336	T44154	T44155	compound	power,output
R11337	T44155	T44153	pobj	output,with
R11338	T44156	T44148	cc	and,increase
R11339	T44157	T44158	advmod	subsequently,failed
R11340	T44158	T44148	conj	failed,increase
R11341	T44159	T44160	det	the,mouse
R11342	T44160	T44158	nsubj	mouse,failed
R11343	T44161	T44162	aux	to,maintain
R11344	T44162	T44158	xcomp	maintain,failed
R11345	T44163	T44162	dobj	effort,maintain
R11346	T44164	T44145	punct	.,determined
R11347	T44166	T44167	nsubjpass	VO2max,calculated
R11348	T44168	T44167	auxpass	was,calculated
R11349	T44169	T44167	advcl	using,calculated
R11350	T44170	T44171	det	the,values
R11351	T44171	T44169	dobj	values,using
R11352	T44172	T44171	amod	averaged,values
R11353	T44173	T44169	prep	over,using
R11354	T44174	T44175	nummod	1,min
R11355	T44175	T44173	pobj	min,over
R11356	T44176	T44177	prep	during,reached
R11357	T44177	T44175	relcl	reached,min
R11358	T44178	T44176	pobj	which,during
R11359	T44179	T44180	det	the,animal
R11360	T44180	T44181	poss	animal,consumption
R11361	T44181	T44177	nsubj	consumption,reached
R11362	T44182	T44180	case	's,animal
R11363	T44183	T44181	compound	O2,consumption
R11364	T44184	T44185	det	a,plateau
R11365	T44185	T44177	dobj	plateau,reached
R11366	T44186	T44167	punct	.,calculated
R11367	T44806	T44807	amod	Isolated,studies
R11368	T44808	T44807	compound	muscle,studies
R11369	T44809	T44807	compound	stimulation,studies
R11370	T44811	T44812	nsubjpass	Animals,anesthetized
R11371	T44813	T44812	auxpass	were,anesthetized
R11372	T44814	T44812	prep	with,anesthetized
R11373	T44815	T44816	compound	ketamine,xylazine
R11374	T44816	T44814	pobj	xylazine,with
R11375	T44817	T44816	punct	/,xylazine
R11376	T44818	T44812	cc	and,anesthetized
R11377	T44819	T44820	det	the,muscle
R11378	T44820	T44822	nsubjpass	muscle,removed
R11379	T44821	T44820	compound	soleus,muscle
R11380	T44822	T44812	conj	removed,anesthetized
R11381	T44823	T44822	auxpass	was,removed
R11382	T44824	T44822	prep	from,removed
R11383	T44825	T44826	nummod	one,leg
R11384	T44826	T44824	pobj	leg,from
R11385	T44827	T44822	punct	.,removed
R11386	T44829	T44830	prep	Upon,suspended
R11387	T44831	T44829	pobj	removal,Upon
R11388	T44832	T44830	punct	", ",suspended
R11389	T44833	T44834	det	the,muscle
R11390	T44834	T44830	nsubjpass	muscle,suspended
R11391	T44835	T44830	auxpass	was,suspended
R11392	T44836	T44830	prep	in,suspended
R11393	T44837	T44838	det	a,solution
R11394	T44838	T44836	pobj	solution,in
R11395	T44839	T44838	compound	Krebs,solution
R11396	T44840	T44838	acl	aerated,solution
R11397	T44841	T44840	prep	with,aerated
R11398	T44842	T44843	nummod	95,%
R11399	T44843	T44844	compound	%,O2
R11400	T44844	T44841	pobj	O2,with
R11401	T44845	T44844	cc	and,O2
R11402	T44846	T44847	nummod	5,%
R11403	T44847	T44848	compound	%,CO2
R11404	T44848	T44844	conj	CO2,O2
R11405	T44849	T44830	punct	.,suspended
R11406	T44851	T44852	det	The,muscle
R11407	T44852	T44853	nsubjpass	muscle,suspended
R11408	T44854	T44852	cc	and,muscle
R11409	T44855	T44856	compound	Krebs,solution
R11410	T44856	T44852	conj	solution,muscle
R11411	T44857	T44853	auxpass	were,suspended
R11412	T44858	T44853	prep	within,suspended
R11413	T44859	T44860	det	a,bath
R11414	T44860	T44858	pobj	bath,within
R11415	T44861	T44860	compound	water,bath
R11416	T44862	T44860	acl	maintained,bath
R11417	T44863	T44862	prep	at,maintained
R11418	T44864	T44865	nummod	37,°C
R11419	T44865	T44863	pobj	°C,at
R11420	T44866	T44853	punct	", ",suspended
R11421	T44867	T44853	cc	and,suspended
R11422	T44868	T44869	det	the,muscle
R11423	T44869	T44870	nsubjpass	muscle,anchored
R11424	T44870	T44853	conj	anchored,suspended
R11425	T44871	T44870	auxpass	was,anchored
R11426	T44872	T44870	prep	to,anchored
R11427	T44873	T44874	det	a,transducer
R11428	T44874	T44872	pobj	transducer,to
R11429	T44875	T44874	nmod	Grass,transducer
R11430	T44876	T44877	punct	(,Warwick
R11431	T44877	T44875	parataxis	Warwick,Grass
R11432	T44878	T44877	compound	West,Warwick
R11433	T44879	T44877	punct	", ",Warwick
R11434	T44880	T44881	compound	Rhode,Island
R11435	T44881	T44877	npadvmod	Island,Warwick
R11436	T44882	T44877	punct	", ",Warwick
R11437	T44883	T44884	compound	United,States
R11438	T44884	T44877	npadvmod	States,Warwick
R11439	T44885	T44877	punct	),Warwick
R11440	T44886	T44874	amod	isometric,transducer
R11441	T44887	T44874	compound	force,transducer
R11442	T44888	T44889	punct	(,FTO3C
R11443	T44889	T44874	parataxis	FTO3C,transducer
R11444	T44890	T44889	compound	model,FTO3C
R11445	T44891	T44889	punct	),FTO3C
R11446	T44892	T44870	punct	.,anchored
R11447	T44894	T44895	nsubjpass	Muscles,stimulated
R11448	T44896	T44895	auxpass	were,stimulated
R11449	T44897	T44898	aux	to,contract
R11450	T44898	T44895	advcl	contract,stimulated
R11451	T44899	T44895	prep	with,stimulated
R11452	T44900	T44901	det	a,stimulator
R11453	T44901	T44899	pobj	stimulator,with
R11454	T44902	T44901	compound	Grass,stimulator
R11455	T44903	T44904	punct	(,S88
R11456	T44904	T44901	parataxis	S88,stimulator
R11457	T44905	T44904	compound	model,S88
R11458	T44906	T44904	punct	),S88
R11459	T44907	T44901	acl	generating,stimulator
R11460	T44908	T44909	det	a,stimulus
R11461	T44909	T44907	dobj	stimulus,generating
R11462	T44910	T44909	compound	field,stimulus
R11463	T44911	T44907	prep	through,generating
R11464	T44912	T44911	pobj	electrodes,through
R11465	T44913	T44912	acl	located,electrodes
R11466	T44914	T44913	prep	at,located
R11467	T44915	T44916	det	both,ends
R11468	T44916	T44914	pobj	ends,at
R11469	T44917	T44916	prep	of,ends
R11470	T44918	T44919	det	the,muscle
R11471	T44919	T44917	pobj	muscle,of
R11472	T44920	T44895	punct	.,stimulated
R11473	T44922	T44923	nmod	Force,voltage
R11474	T44923	T44925	nmod	voltage,relationships
R11475	T44924	T44923	punct	-,voltage
R11476	T44925	T44938	nsubjpass	relationships,determined
R11477	T44926	T44923	punct	(,voltage
R11478	T44927	T44928	amod	maximal,force
R11479	T44928	T44923	appos	force,voltage
R11480	T44929	T44928	prep	at,force
R11481	T44930	T44931	amod	about,100
R11482	T44931	T44932	nummod	100,V
R11483	T44932	T44929	pobj	V,at
R11484	T44933	T44923	punct	),voltage
R11485	T44934	T44923	cc	and,voltage
R11486	T44935	T44936	compound	length,tension
R11487	T44936	T44923	conj	tension,voltage
R11488	T44937	T44936	punct	-,tension
R11489	T44939	T44938	auxpass	were,determined
R11490	T44940	T44938	advcl	using,determined
R11491	T44941	T44942	amod	single,twitch
R11492	T44942	T44943	compound	twitch,stimuli
R11493	T44943	T44940	dobj	stimuli,using
R11494	T44944	T44938	punct	.,determined
R11495	T44946	T44947	det	The,stimulator
R11496	T44947	T44948	nsubj	stimulator,delivered
R11497	T44949	T44948	advmod	then,delivered
R11498	T44950	T44951	amod	repeating,trains
R11499	T44951	T44948	dobj	trains,delivered
R11500	T44952	T44951	prep	of,trains
R11501	T44953	T44952	pobj	stimuli,of
R11502	T44954	T44948	prep	at,delivered
R11503	T44955	T44954	pobj	one,at
R11504	T44956	T44955	prep	per,one
R11505	T44957	T44956	pobj	second,per
R11506	T44958	T44948	prep	at,delivered
R11507	T44959	T44960	nummod	40,Hz
R11508	T44960	T44958	pobj	Hz,at
R11509	T44961	T44948	prep	for,delivered
R11510	T44962	T44963	nummod	2,min
R11511	T44963	T44961	pobj	min,for
R11512	T44964	T44948	punct	.,delivered
R11513	T44966	T44967	det	Each,train
R11514	T44967	T44968	nsubj	train,lasted
R11515	T44969	T44970	nummod	330,ms
R11516	T44970	T44968	npadvmod	ms,lasted
R11517	T44971	T44968	punct	", ",lasted
R11518	T44972	T44968	cc	and,lasted
R11519	T44973	T44974	auxpass	were,recorded
R11520	T44974	T44968	conj	recorded,lasted
R11521	T44975	T44974	advmod	digitally,recorded
R11522	T44976	T44974	advcl	using,recorded
R11523	T44977	T44976	dobj	MacLab,using
R11524	T44978	T44979	punct	(,Instruments
R11525	T44979	T44977	parataxis	Instruments,MacLab
R11526	T44980	T44979	compound	AD,Instruments
R11527	T44981	T44979	punct	", ",Instruments
R11528	T44982	T44983	compound	Colorado,Springs
R11529	T44983	T44979	npadvmod	Springs,Instruments
R11530	T44984	T44979	punct	", ",Instruments
R11531	T44985	T44979	npadvmod	Colorado,Instruments
R11532	T44986	T44979	punct	", ",Instruments
R11533	T44987	T44988	compound	United,States
R11534	T44988	T44979	npadvmod	States,Instruments
R11535	T44989	T44979	punct	),Instruments
R11536	T44990	T44968	punct	.,lasted
R11537	T44992	T44993	compound	Fatigue,resistance
R11538	T44993	T44994	nsubjpass	resistance,calculated
R11539	T44995	T44994	auxpass	was,calculated
R11540	T44996	T44994	prep	as,calculated
R11541	T44997	T44998	det	the,ratio
R11542	T44998	T44996	pobj	ratio,as
R11543	T44999	T44998	prep	of,ratio
R11544	T45000	T45001	det	the,force
R11545	T45001	T44999	pobj	force,of
R11546	T45002	T45001	acl	generated,force
R11547	T45003	T45002	agent	by,generated
R11548	T45004	T45005	det	the,tetanus
R11549	T45005	T45003	pobj	tetanus,by
R11550	T45006	T45005	amod	last,tetanus
R11551	T45007	T45001	acl	divided,force
R11552	T45008	T45007	prep	by,divided
R11553	T45009	T45010	det	the,force
R11554	T45010	T45008	pobj	force,by
R11555	T45011	T45010	amod	highest,force
R11556	T45012	T45010	acl	generated,force
R11557	T45013	T45001	acl	multiplied,force
R11558	T45014	T45013	prep	by,multiplied
R11559	T45015	T45014	pobj	100,by
R11560	T45016	T45017	aux	to,give
R11561	T45017	T44994	advcl	give,calculated
R11562	T45018	T45019	det	the,percent
R11563	T45019	T45017	dobj	percent,give
R11564	T45020	T45019	prep	of,percent
R11565	T45021	T45022	compound	force,generation
R11566	T45022	T45020	pobj	generation,of
R11567	T45023	T45024	dep	that,remained
R11568	T45024	T45019	relcl	remained,percent
R11569	T45025	T45024	prep	after,remained
R11570	T45026	T45027	det	the,protocol
R11571	T45027	T45025	pobj	protocol,after
R11572	T45028	T45027	compound	fatigue,protocol
R11573	T45029	T44994	punct	.,calculated
R11581	T45225	T45224	punct	–,8
R11582	T45226	T45227	npadvmod	mo,old
R11583	T45227	T45219	amod	old,mice
R11584	T45228	T45221	punct	),exercised
R11585	T45229	T45221	auxpass	were,exercised
R11586	T45230	T45221	prep	on,exercised
R11587	T45231	T45232	det	the,treadmill
R11588	T45232	T45230	pobj	treadmill,on
R11589	T45233	T45232	amod	motorized,treadmill
R11590	T45234	T45221	advcl	using,exercised
R11591	T45235	T45236	det	the,settings
R11592	T45236	T45234	dobj	settings,using
R11593	T45237	T45236	nmod	run,settings
R11594	T45238	T45237	punct	-,run
R11595	T45239	T45237	prep	to,run
R11596	T45240	T45239	punct	-,to
R11597	T45241	T45239	pobj	exhaustion,to
R11598	T45242	T45236	acl	described,settings
R11599	T45243	T45242	advmod	above,described
R11600	T45244	T45234	prep	for,using
R11601	T45245	T45246	nummod	60,s
R11602	T45246	T45244	pobj	s,for
R11603	T45247	T45244	cc	or,for
R11604	T45248	T45244	conj	until,for
R11605	T45249	T45248	pobj	exhaustion,until
R11606	T45250	T45251	punct	", ",came
R11607	T45251	T45248	parataxis	came,until
R11608	T45252	T45251	dep	whichever,came
R11609	T45253	T45251	advmod	first,came
R11610	T45254	T45221	punct	.,exercised
R11611	T45256	T45257	advmod	Immediately,following
R11612	T45257	T45258	prep	following,subjected
R11613	T45259	T45260	poss	its,run
R11614	T45260	T45257	pobj	run,following
R11615	T45261	T45260	compound	treadmill,run
R11616	T45262	T45258	punct	", ",subjected
R11617	T45263	T45264	det	the,mouse
R11618	T45264	T45258	nsubjpass	mouse,subjected
R11619	T45265	T45258	auxpass	was,subjected
R11620	T45266	T45258	prep	to,subjected
R11621	T45267	T45268	amod	serial,echocardiography
R11622	T45268	T45266	pobj	echocardiography,to
R11623	T45269	T45258	advcl	using,subjected
R11624	T45270	T45271	det	an,System
R11625	T45271	T45269	dobj	System,using
R11626	T45272	T45273	compound	Acuson,Echocardiography
R11627	T45273	T45271	compound	Echocardiography,System
R11628	T45274	T45273	compound	Sequoia,Echocardiography
R11629	T45275	T45271	acl	performed,System
R11630	T45276	T45277	mark	as,described
R11631	T45277	T45275	advcl	described,performed
R11632	T45278	T45277	advmod	previously,described
R11633	T45279	T45280	punct	[,51
R11634	T45280	T45258	parataxis	51,subjected
R11635	T45281	T45280	punct	],51
R11636	T45282	T45258	punct	.,subjected
R11639	T45734	T45735	advmod	In,vivo
R11640	T45735	T45736	amod	vivo,studies
R11641	T45737	T45736	amod	cardiac,studies
R11642	T45738	T45736	amod	hemodynamic,studies
R11643	T45740	T45741	amod	Hemodynamic,studies
R11644	T45741	T45742	nsubjpass	studies,performed
R11645	T45743	T45742	auxpass	were,performed
R11646	T45744	T45745	mark	as,described
R11647	T45745	T45742	advcl	described,performed
R11648	T45746	T45745	advmod	previously,described
R11649	T45747	T45745	prep	with,described
R11650	T45748	T45749	det	some,modifications
R11651	T45749	T45747	pobj	modifications,with
R11652	T45750	T45751	punct	[,52
R11653	T45751	T45745	parataxis	52,described
R11654	T45752	T45751	punct	],52
R11655	T45753	T45742	punct	.,performed
R11656	T45755	T45756	prep	In,anesthetized
R11657	T45757	T45755	amod	brief,In
R11658	T45758	T45756	punct	", ",anesthetized
R11659	T45759	T45760	amod	adult,mice
R11660	T45760	T45756	nsubjpass	mice,anesthetized
R11661	T45761	T45762	punct	(,wk
R11662	T45762	T45760	parataxis	wk,mice
R11663	T45763	T45764	quantmod	10,12
R11664	T45764	T45762	nummod	12,wk
R11665	T45765	T45764	punct	–,12
R11666	T45766	T45762	punct	),wk
R11667	T45767	T45756	auxpass	were,anesthetized
R11668	T45768	T45756	advmod	intraperitoneally,anesthetized
R11669	T45769	T45770	punct	(,IP
R11670	T45770	T45768	parataxis	IP,intraperitoneally
R11671	T45771	T45770	punct	),IP
R11672	T45772	T45756	prep	with,anesthetized
R11673	T45773	T45774	compound	thiopental,sodium
R11674	T45774	T45772	pobj	sodium,with
R11675	T45775	T45776	punct	(,mg
R11676	T45776	T45774	parataxis	mg,sodium
R11677	T45777	T45776	nummod	60,mg
R11678	T45778	T45779	punct	/,kg
R11679	T45779	T45776	prep	kg,mg
R11680	T45780	T45776	punct	),mg
R11681	T45781	T45756	punct	.,anesthetized
R11682	T45783	T45784	det	The,mice
R11683	T45784	T45785	nsubjpass	mice,intubated
R11684	T45786	T45785	auxpass	were,intubated
R11685	T45787	T45785	cc	and,intubated
R11686	T45788	T45785	conj	ventilated,intubated
R11687	T45789	T45788	prep	with,ventilated
R11688	T45790	T45791	det	a,ventilator
R11689	T45791	T45789	pobj	ventilator,with
R11690	T45792	T45791	compound	Harvard,ventilator
R11691	T45793	T45785	punct	.,intubated
R11692	T45795	T45796	det	The,artery
R11693	T45796	T45799	nsubjpass	artery,isolated
R11694	T45797	T45796	amod	right,artery
R11695	T45798	T45796	compound	carotid,artery
R11696	T45800	T45799	auxpass	was,isolated
R11697	T45801	T45799	prep	in,isolated
R11698	T45802	T45803	det	the,region
R11699	T45803	T45801	pobj	region,in
R11700	T45804	T45803	prep	of,region
R11701	T45805	T45806	det	the,trachea
R11702	T45806	T45804	pobj	trachea,of
R11703	T45807	T45799	cc	and,isolated
R11704	T45808	T45799	conj	cannulated,isolated
R11705	T45809	T45808	prep	with,cannulated
R11706	T45810	T45811	det	a,catheter
R11707	T45811	T45809	pobj	catheter,with
R11708	T45812	T45813	nummod	1.4,French
R11709	T45813	T45811	nmod	French,catheter
R11710	T45814	T45813	punct	-,French
R11711	T45815	T45816	amod	high,fidelity
R11712	T45816	T45811	compound	fidelity,catheter
R11713	T45817	T45816	punct	-,fidelity
R11714	T45818	T45811	compound	micromanometer,catheter
R11715	T45819	T45820	punct	(,Instruments
R11716	T45820	T45811	parataxis	Instruments,catheter
R11717	T45821	T45820	compound	Millar,Instruments
R11718	T45822	T45820	punct	", ",Instruments
R11719	T45823	T45820	npadvmod	Houston,Instruments
R11720	T45824	T45820	punct	", ",Instruments
R11721	T45825	T45820	npadvmod	Texas,Instruments
R11722	T45826	T45820	punct	", ",Instruments
R11723	T45827	T45828	compound	United,States
R11724	T45828	T45820	npadvmod	States,Instruments
R11725	T45829	T45820	punct	),Instruments
R11726	T45830	T45811	punct	", ",catheter
R11727	T45831	T45832	dep	which,inserted
R11728	T45832	T45811	relcl	inserted,catheter
R11729	T45833	T45832	auxpass	was,inserted
R11730	T45834	T45832	prep	into,inserted
R11731	T45835	T45836	det	the,ventricle
R11732	T45836	T45834	pobj	ventricle,into
R11733	T45837	T45836	amod	left,ventricle
R11734	T45838	T45832	advmod	retrograde,inserted
R11735	T45839	T45838	prep	across,retrograde
R11736	T45840	T45841	det	the,valve
R11737	T45841	T45839	pobj	valve,across
R11738	T45842	T45841	amod	aortic,valve
R11739	T45843	T45799	punct	.,isolated
R11740	T45845	T45846	amod	Hemodynamic,measurements
R11741	T45846	T45847	nsubjpass	measurements,recorded
R11742	T45848	T45847	auxpass	were,recorded
R11743	T45849	T45847	prep	at,recorded
R11744	T45850	T45849	pobj	baseline,at
R11745	T45851	T45849	cc	and,at
R11746	T45852	T45853	nummod	3,min
R11747	T45853	T45854	npadvmod	min,following
R11748	T45854	T45849	conj	following,at
R11749	T45855	T45856	amod	continuous,infusion
R11750	T45856	T45854	pobj	infusion,following
R11751	T45857	T45856	prep	of,infusion
R11752	T45858	T45859	amod	incremental,doses
R11753	T45859	T45857	pobj	doses,of
R11754	T45860	T45859	prep	of,doses
R11755	T45861	T45860	pobj	dobutamine,of
R11756	T45862	T45861	punct	(,dobutamine
R11757	T45863	T45864	npadvmod	β1,adrenergic
R11758	T45864	T45871	amod	adrenergic,agonist
R11759	T45865	T45863	punct	", ",β1
R11760	T45866	T45863	conj	β2,β1
R11761	T45867	T45866	punct	", ",β2
R11762	T45868	T45866	cc	and,β2
R11763	T45869	T45866	conj	α1,β2
R11764	T45870	T45864	punct	-,adrenergic
R11765	T45871	T45861	appos	agonist,dobutamine
R11766	T45872	T45859	punct	),doses
R11767	T45873	T45859	prep	up,doses
R11768	T45874	T45873	prep	to,up
R11769	T45875	T45876	nummod	32,ng
R11770	T45876	T45874	pobj	ng,to
R11771	T45877	T45876	punct	·,ng
R11772	T45878	T45876	appos	gBW,ng
R11773	T45879	T45880	punct	−,1
R11774	T45880	T45878	nummod	1,gBW
R11775	T45881	T45876	punct	·,ng
R11776	T45882	T45876	appos	min,ng
R11777	T45883	T45884	punct	−,1
R11778	T45884	T45882	nummod	1,min
R11779	T45885	T45886	punct	[,53
R11780	T45886	T45847	parataxis	53,recorded
R11781	T45887	T45886	punct	],53
R11782	T45888	T45847	punct	.,recorded
R11783	T45890	T45891	amod	Continuous,data
R11784	T45891	T45895	nsubjpass	data,acquired
R11785	T45892	T45893	compound	pressure,volume
R11786	T45893	T45891	compound	volume,data
R11787	T45894	T45893	punct	-,volume
R11788	T45896	T45895	auxpass	were,acquired
R11789	T45897	T45895	cc	and,acquired
R11790	T45898	T45895	conj	digitized,acquired
R11791	T45899	T45898	prep	with,digitized
R11792	T45900	T45901	det	the,system
R11793	T45901	T45899	pobj	system,with
R11794	T45902	T45903	compound	BioBench,software
R11795	T45903	T45901	compound	software,system
R11796	T45904	T45903	compound	computer,software
R11797	T45905	T45906	compound	data,acquisition
R11798	T45906	T45901	compound	acquisition,system
R11799	T45907	T45908	punct	(,Instruments
R11800	T45908	T45901	parataxis	Instruments,system
R11801	T45909	T45908	compound	National,Instruments
R11802	T45910	T45908	punct	", ",Instruments
R11803	T45911	T45908	npadvmod	Austin,Instruments
R11804	T45912	T45908	punct	", ",Instruments
R11805	T45913	T45908	npadvmod	Texas,Instruments
R11806	T45914	T45908	punct	", ",Instruments
R11807	T45915	T45916	compound	United,States
R11808	T45916	T45908	npadvmod	States,Instruments
R11809	T45917	T45908	punct	),Instruments
R11810	T45918	T45895	punct	.,acquired
R11811	T46753	T46754	amod	Isolated,perfusion
R11812	T46755	T46754	amod	working,perfusion
R11813	T46756	T46757	compound	mouse,heart
R11814	T46757	T46754	compound	heart,perfusion
R11815	T46759	T46760	amod	Isolated,perfusion
R11816	T46760	T46764	nsubjpass	perfusion,based
R11817	T46761	T46760	amod	working,perfusion
R11818	T46762	T46763	compound	mouse,heart
R11819	T46763	T46760	compound	heart,perfusion
R11820	T46765	T46764	auxpass	was,based
R11821	T46766	T46764	prep	on,based
R11822	T46767	T46768	det	a,procedure
R11823	T46768	T46766	pobj	procedure,on
R11824	T46769	T46770	advmod	previously,described
R11825	T46770	T46768	amod	described,procedure
R11826	T46771	T46772	punct	[,54
R11827	T46772	T46768	parataxis	54,procedure
R11828	T46773	T46772	punct	],54
R11829	T46774	T46764	punct	.,based
R11830	T46776	T46777	amod	Adult,mice
R11831	T46777	T46778	nsubjpass	mice,heparinized
R11832	T46779	T46780	punct	(,old
R11833	T46780	T46777	parataxis	old,mice
R11834	T46781	T46782	quantmod	4,7
R11835	T46782	T46784	nummod	7,mo
R11836	T46783	T46782	punct	–,7
R11837	T46784	T46780	npadvmod	mo,old
R11838	T46785	T46780	punct	),old
R11839	T46786	T46778	auxpass	were,heparinized
R11840	T46787	T46788	punct	(,units
R11841	T46788	T46778	parataxis	units,heparinized
R11842	T46789	T46788	nummod	100,units
R11843	T46790	T46788	advmod	IP,units
R11844	T46791	T46788	punct	),units
R11845	T46792	T46793	nummod	10,min
R11846	T46793	T46794	npadvmod	min,to
R11847	T46794	T46778	prep	to,heparinized
R11848	T46795	T46794	amod	prior,to
R11849	T46796	T46794	pobj	anesthesia,to
R11850	T46797	T46778	punct	.,heparinized
R11851	T46799	T46800	nsubjpass	Animals,anesthetized
R11852	T46801	T46800	auxpass	were,anesthetized
R11853	T46802	T46800	advmod	then,anesthetized
R11854	T46803	T46800	advmod	deeply,anesthetized
R11855	T46804	T46800	prep	with,anesthetized
R11856	T46805	T46806	quantmod	5,10
R11857	T46806	T46808	nummod	10,mg
R11858	T46807	T46806	punct	–,10
R11859	T46808	T46804	pobj	mg,with
R11860	T46809	T46808	prep	of,mg
R11861	T46810	T46811	compound	sodium,pentobarbital
R11862	T46811	T46809	pobj	pentobarbital,of
R11863	T46812	T46800	advmod	IP,anesthetized
R11864	T46813	T46800	punct	.,anesthetized
R11865	T46815	T46816	nsubjpass	Hearts,excised
R11866	T46817	T46816	auxpass	were,excised
R11867	T46818	T46816	cc	and,excised
R11868	T46819	T46816	conj	placed,excised
R11869	T46820	T46819	prep	in,placed
R11870	T46821	T46822	det	an,solution
R11871	T46822	T46820	pobj	solution,in
R11872	T46823	T46824	npadvmod	ice,cold
R11873	T46824	T46822	amod	cold,solution
R11874	T46825	T46824	punct	-,cold
R11875	T46826	T46827	nmod	Krebs,Henseleit
R11876	T46827	T46829	nmod	Henseleit,bicarbonate
R11877	T46828	T46827	punct	-,Henseleit
R11878	T46829	T46822	nmod	bicarbonate,solution
R11879	T46830	T46829	punct	(,bicarbonate
R11880	T46831	T46829	appos	KHB,bicarbonate
R11881	T46832	T46822	punct	),solution
R11882	T46833	T46822	punct	[,solution
R11883	T46834	T46835	nummod	118,mM
R11884	T46835	T46836	compound	mM,NaCl
R11885	T46836	T46822	appos	NaCl,solution
R11886	T46837	T46836	punct	", ",NaCl
R11887	T46838	T46839	nummod	25,mM
R11888	T46839	T46840	compound	mM,NaHCO3
R11889	T46840	T46836	conj	NaHCO3,NaCl
R11890	T46841	T46840	punct	", ",NaHCO3
R11891	T46842	T46843	nummod	4.7,mM
R11892	T46843	T46844	compound	mM,KCl
R11893	T46844	T46840	conj	KCl,NaHCO3
R11894	T46845	T46844	punct	", ",KCl
R11895	T46846	T46847	nummod	1.2,mM
R11896	T46847	T46848	compound	mM,KH2PO4
R11897	T46848	T46844	conj	KH2PO4,KCl
R11898	T46849	T46848	punct	", ",KH2PO4
R11899	T46850	T46851	nummod	2.5,mM
R11900	T46851	T46852	compound	mM,CaCl2
R11901	T46852	T46848	conj	CaCl2,KH2PO4
R11902	T46853	T46852	punct	", ",CaCl2
R11903	T46854	T46855	nummod	5.0,mM
R11904	T46855	T46856	compound	mM,glucose
R11905	T46856	T46852	conj	glucose,CaCl2
R11906	T46857	T46856	punct	", ",glucose
R11907	T46858	T46856	cc	and,glucose
R11908	T46859	T46860	nummod	100,units
R11909	T46860	T46856	conj	units,glucose
R11910	T46861	T46862	punct	/,insulin
R11911	T46862	T46860	prep	insulin,units
R11912	T46863	T46862	compound	L,insulin
R11913	T46864	T46865	punct	(,pH
R11914	T46865	T46860	parataxis	pH,units
R11915	T46866	T46865	nummod	7.4,pH
R11916	T46867	T46865	punct	),pH
R11917	T46868	T46816	punct	],excised
R11918	T46869	T46816	punct	.,excised
R11919	T46871	T46872	nsubjpass	Hearts,cannulated
R11920	T46873	T46872	auxpass	were,cannulated
R11921	T46874	T46872	advmod	first,cannulated
R11922	T46875	T46872	prep	via,cannulated
R11923	T46876	T46877	det	the,aorta
R11924	T46877	T46875	pobj	aorta,via
R11925	T46878	T46872	cc	and,cannulated
R11926	T46879	T46872	conj	perfused,cannulated
R11927	T46880	T46879	advmod	retrogradely,perfused
R11928	T46881	T46879	prep	by,perfused
R11929	T46882	T46883	det	the,method
R11930	T46883	T46881	pobj	method,by
R11931	T46884	T46883	compound	Langendorff,method
R11932	T46885	T46872	punct	.,cannulated
R11933	T46887	T46888	prep	Following,switched
R11934	T46889	T46890	amod	left,cannulation
R11935	T46890	T46887	pobj	cannulation,Following
R11936	T46891	T46890	amod	atrial,cannulation
R11937	T46892	T46888	punct	", ",switched
R11938	T46893	T46888	nsubjpass	perfusion,switched
R11939	T46894	T46888	auxpass	was,switched
R11940	T46895	T46888	prep	to,switched
R11941	T46896	T46897	det	the,mode
R11942	T46897	T46895	pobj	mode,to
R11943	T46898	T46897	amod	working,mode
R11944	T46899	T46900	mark	with,bound
R11945	T46900	T46888	advcl	bound,switched
R11946	T46901	T46902	compound	KHB,solution
R11947	T46902	T46900	nsubj	solution,bound
R11948	T46903	T46902	acl	containing,solution
R11949	T46904	T46905	nummod	1.2,mM
R11950	T46905	T46906	compound	mM,palmitate
R11951	T46906	T46903	dobj	palmitate,containing
R11952	T46907	T46900	prep	to,bound
R11953	T46908	T46909	nummod	3,%
R11954	T46909	T46910	nmod	%,BSA
R11955	T46910	T46907	pobj	BSA,to
R11956	T46911	T46912	amod	fatty,acid
R11957	T46912	T46913	npadvmod	acid,free
R11958	T46913	T46910	amod	free,BSA
R11959	T46914	T46913	punct	-,free
R11960	T46915	T46900	prep	with,bound
R11961	T46916	T46917	det	a,pressure
R11962	T46917	T46915	pobj	pressure,with
R11963	T46918	T46917	amod	preload,pressure
R11964	T46919	T46917	prep	of,pressure
R11965	T46920	T46921	nummod	11.5,mm
R11966	T46921	T46922	compound	mm,Hg
R11967	T46922	T46919	pobj	Hg,of
R11968	T46923	T46917	cc	and,pressure
R11969	T46924	T46925	det	an,pressure
R11970	T46925	T46917	conj	pressure,pressure
R11971	T46926	T46925	amod	afterload,pressure
R11972	T46927	T46925	prep	of,pressure
R11973	T46928	T46929	nummod	50,mm
R11974	T46929	T46930	compound	mm,Hg
R11975	T46930	T46927	pobj	Hg,of
R11976	T46931	T46900	prep	for,bound
R11977	T46932	T46933	nummod	60,min
R11978	T46933	T46931	pobj	min,for
R11979	T46934	T46900	prep	with,bound
R11980	T46935	T46936	amod	oxygenated,solution
R11981	T46936	T46934	pobj	solution,with
R11982	T46937	T46936	compound	buffer,solution
R11983	T46938	T46888	punct	.,switched
R11984	T46940	T46941	amod	Functional,measurements
R11985	T46941	T46942	nsubjpass	measurements,acquired
R11986	T46943	T46941	punct	", ",measurements
R11987	T46944	T46945	advmod	namely,output
R11988	T46945	T46941	appos	output,measurements
R11989	T46946	T46945	amod	cardiac,output
R11990	T46947	T46945	punct	", ",output
R11991	T46948	T46949	amod	aortic,flows
R11992	T46949	T46945	conj	flows,output
R11993	T46950	T46949	punct	", ",flows
R11994	T46951	T46952	amod	peak,pressure
R11995	T46952	T46949	conj	pressure,flows
R11996	T46953	T46952	amod	systolic,pressure
R11997	T46954	T46952	punct	", ",pressure
R11998	T46955	T46952	cc	and,pressure
R11999	T46956	T46957	compound	heart,rate
R12000	T46957	T46952	conj	rate,pressure
R12001	T46958	T46942	auxpass	were,acquired
R12002	T46959	T46960	det	every,min
R12003	T46960	T46942	npadvmod	min,acquired
R12004	T46961	T46960	nummod	10,min
R12005	T46962	T46942	advcl	using,acquired
R12006	T46963	T46964	compound	inline,probes
R12007	T46964	T46962	dobj	probes,using
R12008	T46965	T46964	compound	flow,probes
R12009	T46966	T46967	punct	(,Systems
R12010	T46967	T46964	parataxis	Systems,probes
R12011	T46968	T46967	compound	Transonic,Systems
R12012	T46969	T46967	punct	", ",Systems
R12013	T46970	T46967	npadvmod	Ithaca,Systems
R12014	T46971	T46967	punct	", ",Systems
R12015	T46972	T46973	compound	New,York
R12016	T46973	T46967	npadvmod	York,Systems
R12017	T46974	T46967	punct	", ",Systems
R12018	T46975	T46976	compound	United,States
R12019	T46976	T46967	npadvmod	States,Systems
R12020	T46977	T46967	punct	),Systems
R12021	T46978	T46964	punct	", ",probes
R12022	T46979	T46980	det	a,transducer
R12023	T46980	T46964	conj	transducer,probes
R12024	T46981	T46980	compound	pressure,transducer
R12025	T46982	T46983	punct	(,104A
R12026	T46983	T46980	parataxis	104A,transducer
R12027	T46984	T46983	compound	TSD,104A
R12028	T46985	T46983	punct	", ",104A
R12029	T46986	T46987	compound	BIOPAC,Systems
R12030	T46987	T46983	npadvmod	Systems,104A
R12031	T46988	T46983	punct	", ",104A
R12032	T46989	T46990	compound	Santa,Barbara
R12033	T46990	T46983	npadvmod	Barbara,104A
R12034	T46991	T46983	punct	", ",104A
R12035	T46992	T46983	npadvmod	California,104A
R12036	T46993	T46983	punct	", ",104A
R12037	T46994	T46995	compound	United,States
R12038	T46995	T46983	npadvmod	States,104A
R12039	T46996	T46983	punct	),104A
R12040	T46997	T46980	cc	and,transducer
R12041	T46998	T46980	conj	data,transducer
R12042	T46999	T46998	acl	acquired,data
R12043	T47000	T46999	prep	with,acquired
R12044	T47001	T47002	det	the,system
R12045	T47002	T47000	pobj	system,with
R12046	T47003	T47002	compound	MP100,system
R12047	T47004	T47002	prep	from,system
R12048	T47005	T47004	pobj	AcqKnowledge,from
R12049	T47006	T47007	punct	(,Systems
R12050	T47007	T47005	parataxis	Systems,AcqKnowledge
R12051	T47008	T47007	compound	BIOPAC,Systems
R12052	T47009	T47007	punct	),Systems
R12053	T47010	T46942	punct	.,acquired
R12054	T47012	T47013	amod	Cardiac,work
R12055	T47013	T47014	nsubjpass	work,calculated
R12056	T47015	T47014	auxpass	was,calculated
R12057	T47016	T47014	prep	as,calculated
R12058	T47017	T47018	det	the,product
R12059	T47018	T47016	pobj	product,as
R12060	T47019	T47018	prep	of,product
R12061	T47020	T47021	nmod	peak,pressure
R12062	T47021	T47019	pobj	pressure,of
R12063	T47022	T47021	amod	systolic,pressure
R12064	T47023	T47021	cc	and,pressure
R12065	T47024	T47025	amod	cardiac,output
R12066	T47025	T47021	conj	output,pressure
R12067	T47026	T47014	punct	.,calculated
R12068	T47484	T47485	nsubjpass	Data,analyzed
R12069	T47486	T47485	auxpass	were,analyzed
R12070	T47487	T47485	advcl	using,analyzed
R12071	T47488	T47489	compound	T,tests
R12072	T47489	T47487	dobj	tests,using
R12073	T47490	T47489	punct	-,tests
R12074	T47491	T47489	cc	or,tests
R12075	T47492	T47489	conj	ANOVAs,tests
R12076	T47493	T47494	punct	(,measures
R12077	T47494	T47492	parataxis	measures,ANOVAs
R12078	T47495	T47494	prep	of,measures
R12079	T47496	T47497	amod	general,activity
R12080	T47497	T47495	pobj	activity,of
R12081	T47498	T47497	cc	and,activity
R12082	T47499	T47500	compound	sensorimotor,battery
R12083	T47500	T47497	conj	battery,activity
R12084	T47501	T47494	punct	),measures
R12085	T47502	T47485	punct	.,analyzed
R12086	T47504	T47505	det	The,level
R12087	T47505	T47506	nsubjpass	level,set
R12088	T47507	T47505	prep	of,level
R12089	T47508	T47507	pobj	significance,of
R12090	T47509	T47506	auxpass	was,set
R12091	T47510	T47506	prep	at,set
R12092	T47511	T47510	pobj	p,at
R12093	T47512	T47513	punct	<,0.05
R12094	T47513	T47511	amod	0.05,p
R12095	T47514	T47506	prep	in,set
R12096	T47515	T47516	det	all,cases
R12097	T47516	T47514	pobj	cases,in
R12098	T47517	T47506	punct	.,set
R12099	T47519	T47520	nsubjpass	Data,reported
R12100	T47521	T47520	auxpass	are,reported
R12101	T47522	T47520	prep	as,reported
R12102	T47523	T47524	compound	mean,values
R12103	T47524	T47522	pobj	values,as
R12104	T47525	T47524	punct	±,values
R12105	T47526	T47524	appos	SEM,values
R12106	T47527	T47520	punct	", ",reported
R12107	T47528	T47529	mark	unless,noted
R12108	T47529	T47520	advcl	noted,reported
R12109	T47530	T47529	advmod	otherwise,noted
R12110	T47531	T47520	punct	.,reported
R12111	T47533	T47534	det	The,model
R12112	T47534	T47536	nsubj	model,included
R12113	T47535	T47534	compound	ANOVA,model
R12114	T47537	T47534	acl	used,model
R12115	T47538	T47539	aux	to,analyze
R12116	T47539	T47537	advcl	analyze,used
R12117	T47540	T47541	det	each,test
R12118	T47541	T47539	dobj	test,analyze
R12119	T47542	T47541	compound	sensorimotor,test
R12120	T47543	T47544	nummod	one,between
R12121	T47544	T47536	dobj	between,included
R12122	T47545	T47544	punct	-,between
R12123	T47546	T47544	pobj	subjects,between
R12124	T47547	T47544	amod	variable,between
R12125	T47548	T47549	punct	(,genotype
R12126	T47549	T47544	parataxis	genotype,between
R12127	T47550	T47549	punct	),genotype
R12128	T47551	T47544	punct	", ",between
R12129	T47552	T47544	cc	and,between
R12130	T47553	T47554	nummod	one,within
R12131	T47554	T47544	conj	within,between
R12132	T47555	T47554	punct	-,within
R12133	T47556	T47554	pobj	subjects,within
R12134	T47557	T47554	amod	variable,within
R12135	T47558	T47559	punct	(,trials
R12136	T47559	T47554	parataxis	trials,within
R12137	T47560	T47559	punct	),trials
R12138	T47561	T47536	punct	.,included
R12139	T47563	T47564	advmod	When,conducted
R12140	T47564	T47570	advcl	conducted,used
R12141	T47565	T47564	nsubjpass	ANOVAs,conducted
R12142	T47566	T47565	prep	with,ANOVAs
R12143	T47567	T47568	amod	repeated,measures
R12144	T47568	T47566	pobj	measures,with
R12145	T47569	T47564	auxpass	were,conducted
R12146	T47571	T47570	punct	", ",used
R12147	T47572	T47573	det	the,adjustment
R12148	T47573	T47570	nsubjpass	adjustment,used
R12149	T47574	T47575	nmod	Huynh,Feldt
R12150	T47575	T47573	nmod	Feldt,adjustment
R12151	T47576	T47575	punct	-,Feldt
R12152	T47577	T47575	punct	(,Feldt
R12153	T47578	T47579	compound	H,F
R12154	T47579	T47575	appos	F,Feldt
R12155	T47580	T47579	punct	-,F
R12156	T47581	T47573	punct	),adjustment
R12157	T47582	T47573	prep	of,adjustment
R12158	T47583	T47584	compound	alpha,levels
R12159	T47584	T47582	pobj	levels,of
R12160	T47585	T47570	auxpass	was,used
R12161	T47586	T47570	prep	for,used
R12162	T47587	T47588	det	all,effects
R12163	T47588	T47586	pobj	effects,for
R12164	T47589	T47588	nmod	within,effects
R12165	T47590	T47589	punct	-,within
R12166	T47591	T47589	pobj	subjects,within
R12167	T47592	T47588	acl	containing,effects
R12168	T47593	T47594	amod	more,two
R12169	T47594	T47596	nummod	two,levels
R12170	T47595	T47594	quantmod	than,two
R12171	T47596	T47592	dobj	levels,containing
R12172	T47597	T47570	punct	", ",used
R12173	T47598	T47570	prep	in,used
R12174	T47599	T47598	pobj	order,in
R12175	T47600	T47601	aux	to,protect
R12176	T47601	T47599	acl	protect,order
R12177	T47602	T47601	prep	against,protect
R12178	T47603	T47602	pobj	violations,against
R12179	T47604	T47603	prep	of,violations
R12180	T47605	T47606	det	the,assumptions
R12181	T47606	T47604	pobj	assumptions,of
R12182	T47607	T47606	nmod	sphericity,assumptions
R12183	T47608	T47607	punct	/,sphericity
R12184	T47609	T47610	amod	compound,symmetry
R12185	T47610	T47607	appos	symmetry,sphericity
R12186	T47611	T47606	acl	underlying,assumptions
R12187	T47612	T47613	det	this,model
R12188	T47613	T47611	dobj	model,underlying
R12189	T47614	T47613	compound	ANOVA,model
R12190	T47615	T47570	punct	.,used
R12191	T47617	T47618	prep	In,used
R12192	T47619	T47617	pobj	addition,In
R12193	T47620	T47618	punct	", ",used
R12194	T47621	T47622	compound	Bonferroni,correction
R12195	T47622	T47618	nsubjpass	correction,used
R12196	T47623	T47618	auxpass	was,used
R12197	T47624	T47625	advmod	when,appropriate
R12198	T47625	T47618	advcl	appropriate,used
R12199	T47626	T47627	aux	to,help
R12200	T47627	T47618	advcl	help,used
R12201	T47628	T47627	xcomp	maintain,help
R12202	T47629	T47630	amod	prescribed,levels
R12203	T47630	T47628	dobj	levels,maintain
R12204	T47631	T47630	compound	alpha,levels
R12205	T47632	T47633	punct	(,p
R12206	T47633	T47630	parataxis	p,levels
R12207	T47634	T47633	advmod	e.g.,p
R12208	T47635	T47633	punct	", ",p
R12209	T47636	T47637	punct	<,0.05
R12210	T47637	T47633	amod	0.05,p
R12211	T47638	T47633	punct	),p
R12212	T47639	T47640	advmod	when,conducted
R12213	T47640	T47628	advcl	conducted,maintain
R12214	T47641	T47642	amod	multiple,comparisons
R12215	T47642	T47640	nsubjpass	comparisons,conducted
R12216	T47643	T47640	auxpass	were,conducted
R12217	T47644	T47618	punct	.,used
R10108	T39319	T39320	amod	Indirect,calorimetry
R10109	T39322	T39323	compound	Oxygen,rates
R10110	T39323	T39325	nsubjpass	rates,measured
R10111	T39324	T39323	compound	consumption,rates
R10112	T39326	T39323	punct	(,rates
R11574	T45215	T45216	compound	Exercise,echocardiography
R11575	T45218	T45219	amod	Adult,mice
R11576	T45219	T45221	nsubjpass	mice,exercised
R11577	T45220	T45219	amod	female,mice
R11578	T45222	T45219	punct	(,mice
R11579	T45223	T45224	quantmod	6,8
R11580	T45224	T45226	nummod	8,mo
R8	T734	T732	dobj	Derangements,Causes
R90	T825	T823	pobj	demands,with
R203	T946	T944	pobj	response,with
R228	T973	T971	pobj	capacity,of
R269	T1018	T1016	pobj	system,in
R1517	T6147	T6146	pobj	heart,in
R2068	T8236	T8235	punct	", ",exhibit
R2069	T8237	T8238	amod	certain,tissues
R2075	T8241	T8239	pobj	requirements,with
R2085	T8248	T8246	pobj	muscle,as
R2889	T12840	T12839	prep	as,long
R2890	T12841	T12842	det	the,controls
R3221	T13192	T13191	prep	in,difference
R5198	T20993	T20992	punct	-,1α
R438	T3649	T3648	amod	additional,members
R1006	T4252	T4249	punct	", ",established
R1007	T4253	T4249	nsubj	we,established
R1008	T4254	T4249	aux	have,established
R1020	T4263	T4261	pobj	gene,of
R6252	T30671	T30669	conj	liver,muscle
R6913	T31385	T31386	compound	PGC,1α
R6917	T31388	T31389	det	the,receptor
R7457	T31970	T31971	nmod	PGC,1α
R7585	T32106	T32105	punct	-,1α
R7587	T32107	T32103	amod	null,mice
R7591	T32112	T32113	det	the,preparation
R7931	T32475	T32474	punct	-,induced
R7933	T32476	T32472	pobj	obesity,to
R7934	T32477	T32471	amod	similar,resistance
R8614	T33201	T33198	conj	diseases,steatosis
R8615	T33202	T33201	prep	of,diseases
R8616	T33203	T33204	det	the,heart
R8586	T33181	T33179	pobj	model,as
R8588	T33182	T33181	amod	useful,model
R8589	T33183	T33181	amod	murine,model
R8590	T33184	T33185	aux	to,investigate
R8592	T33185	T33181	advcl	investigate,model
R8593	T33186	T33187	det	the,role
R8594	T33187	T33185	dobj	role,investigate
R8596	T33188	T33187	prep	of,role
R8597	T33189	T33190	amod	altered,metabolism
R8599	T33190	T33188	pobj	metabolism,of
R8600	T33191	T33190	compound	energy,metabolism
R8601	T33192	T33187	prep	in,role
R8603	T33193	T33192	pobj	obesity,in
R8604	T33194	T33193	punct	", ",obesity
R8606	T33195	T33193	conj	diabetes,obesity
R8607	T33196	T33195	punct	", ",diabetes
R8608	T33197	T33198	amod	hepatic,steatosis
R8610	T33198	T33195	conj	steatosis,diabetes
R8611	T33199	T33198	punct	", ",steatosis
R8612	T33200	T33198	cc	and,steatosis
R8618	T33204	T33202	pobj	heart,of
R8619	T33205	T33204	punct	", ",heart
R8621	T33206	T33207	amod	skeletal,muscle
R8622	T33207	T33204	conj	muscle,heart
R8623	T33208	T33207	punct	", ",muscle
R8624	T33209	T33207	cc	and,muscle
R8625	T33210	T33211	amod	central,system
R8626	T33211	T33207	conj	system,muscle
R8628	T33212	T33211	amod	nervous,system
R8629	T33213	T33165	punct	.,propose

2_test

Id	Subject	Object	Predicate	Lexical cue
15760270-15004004-84758658	2300-2301	15004004	denotes	1
15760270-15004004-84758659	2618-2619	15004004	denotes	1
15760270-9529258-84758660	2620-2621	9529258	denotes	2
15760270-9529258-84758661	2768-2769	9529258	denotes	2
15760270-11340167-84758662	2872-2873	11340167	denotes	3
15760270-11854298-84758663	2887-2888	11854298	denotes	4
15760270-11733490-84758664	2889-2890	11733490	denotes	5
15760270-12588810-84758665	3044-3045	12588810	denotes	6
15760270-9529258-84758666	3269-3270	9529258	denotes	2
15760270-12588810-84758667	3271-3272	12588810	denotes	6
15760270-11551810-84758668	3273-3274	11551810	denotes	7
15760270-9529258-84758669	3542-3543	9529258	denotes	2
15760270-10412986-84758670	3544-3545	10412986	denotes	8
15760270-10913342-84758671	3546-3547	10913342	denotes	9
15760270-11018072-84758672	3548-3550	11018072	denotes	10
15760270-12468452-84758673	3551-3553	12468452	denotes	11
15760270-12163024-84758674	3554-3556	12163024	denotes	12
15760270-12734114-84758675	3557-3559	12734114	denotes	13
15760270-12563009-84758676	3560-3562	12563009	denotes	14
15760270-14570700-84758677	3563-3565	14570700	denotes	15
15760270-9529258-84758678	4049-4050	9529258	denotes	2
15760270-10412986-84758679	4436-4437	10412986	denotes	8
15760270-11018072-84758680	4614-4616	11018072	denotes	10
15760270-14726475-84758681	4617-4619	14726475	denotes	16
15760270-12181572-84758682	4822-4824	12181572	denotes	17
15760270-11557984-84758683	5097-5099	11557984	denotes	18
15760270-11557972-84758684	5100-5102	11557972	denotes	19
15760270-12754525-84758685	5103-5105	12754525	denotes	20
15760270-15107844-84758686	5106-5108	15107844	denotes	21
15760270-12808457-84758687	5283-5285	12808457	denotes	22
15760270-12832613-84758688	5286-5288	12832613	denotes	23
15760270-14960743-84758689	5289-5291	14960743	denotes	24
15760270-11793024-84758690	5443-5445	11793024	denotes	25
15760270-11916956-84758691	5446-5448	11916956	denotes	26
15760270-12107756-84758692	5449-5451	12107756	denotes	27
15760270-12032643-84758693	5452-5454	12032643	denotes	28
15760270-12574109-84758694	5455-5457	12574109	denotes	29
15760270-15111510-84758695	5458-5460	15111510	denotes	30
15760270-9529258-84758696	28076-28077	9529258	denotes	2
15760270-9529258-84758697	30517-30518	9529258	denotes	2
15760270-11557984-84758698	31822-31824	11557984	denotes	18
15760270-11557972-84758699	31825-31827	11557972	denotes	19
15760270-12754525-84758700	31828-31830	12754525	denotes	20
15760270-15107844-84758701	31831-31833	15107844	denotes	21
15760270-10669761-84758702	35274-35276	10669761	denotes	31
15760270-12107756-84758703	38430-38432	12107756	denotes	27
15760270-15111510-84758704	38433-38435	15111510	denotes	30
15760270-12808457-84758705	38517-38519	12808457	denotes	22
15760270-12832613-84758706	38520-38522	12832613	denotes	23
15760270-12588810-84758707	43617-43618	12588810	denotes	6
15760270-12832613-84758708	43813-43815	12832613	denotes	23
15760270-15100410-84758709	43816-43818	15100410	denotes	32
15760270-9529258-84758710	46110-46111	9529258	denotes	2
15760270-14729567-84758711	48495-48497	14729567	denotes	33
15760270-11916956-84758712	49530-49532	11916956	denotes	26
15760270-14960743-84758713	50151-50153	14960743	denotes	24
15760270-12750520-84758714	50154-50156	12750520	denotes	34
15760270-15107844-84758715	50576-50578	15107844	denotes	21
15760270-11306606-84758716	50579-50581	11306606	denotes	35
15760270-12847522-84758717	50582-50584	12847522	denotes	36
15760270-15454086-84758718	52147-52149	15454086	denotes	37
15760270-14585956-84758719	53804-53806	14585956	denotes	38
15760270-12067905-84758720	59779-59781	12067905	denotes	39
15760270-2808399-84758721	61184-61186	2808399	denotes	40
15760270-15456881-84758722	61376-61378	15456881	denotes	41
15760270-15241186-84758723	61912-61914	15241186	denotes	42
15760270-8967442-84758724	62450-62452	8967442	denotes	43
15760270-9746314-84758725	62871-62873	9746314	denotes	44
15760270-11306606-84758726	64222-64224	11306606	denotes	35
15760270-10441518-84758727	65004-65006	10441518	denotes	45
15760270-11018072-84758728	65610-65612	11018072	denotes	10
15760270-14578206-84758729	65902-65904	14578206	denotes	46
15760270-10893242-84758730	66431-66433	10893242	denotes	47
15760270-10893242-84758731	66618-66620	10893242	denotes	47
15760270-12618083-84758732	66709-66711	12618083	denotes	48
15760270-10864938-84758733	67358-67360	10864938	denotes	49
15760270-12123606-84758734	68417-68419	12123606	denotes	50
15760270-10487771-84758735	72716-72718	10487771	denotes	51
15760270-1832775-84758736	72842-72844	1832775	denotes	52
15760270-9612396-84758737	73481-73483	9612396	denotes	53
15760270-10516264-84758738	73786-73788	10516264	denotes	54
T54007	2300-2301	15004004	denotes	1
T90426	2618-2619	15004004	denotes	1
T21973	2620-2621	9529258	denotes	2
T88864	2768-2769	9529258	denotes	2
T53430	2872-2873	11340167	denotes	3
T1401	2887-2888	11854298	denotes	4
T26577	2889-2890	11733490	denotes	5
T6831	3044-3045	12588810	denotes	6
T25026	3269-3270	9529258	denotes	2
T55288	3271-3272	12588810	denotes	6
T3864	3273-3274	11551810	denotes	7
T34421	3542-3543	9529258	denotes	2
T54556	3544-3545	10412986	denotes	8
T13820	3546-3547	10913342	denotes	9
T22334	3548-3550	11018072	denotes	10
T88642	3551-3553	12468452	denotes	11
T33538	3554-3556	12163024	denotes	12
T69720	3557-3559	12734114	denotes	13
T25324	3560-3562	12563009	denotes	14
T31848	3563-3565	14570700	denotes	15
T23860	4049-4050	9529258	denotes	2
T60569	4436-4437	10412986	denotes	8
T38150	4614-4616	11018072	denotes	10
T11642	4617-4619	14726475	denotes	16
T19546	4822-4824	12181572	denotes	17
T4003	5097-5099	11557984	denotes	18
T41889	5100-5102	11557972	denotes	19
T75782	5103-5105	12754525	denotes	20
T60692	5106-5108	15107844	denotes	21
T70580	5283-5285	12808457	denotes	22
T17316	5286-5288	12832613	denotes	23
T4793	5289-5291	14960743	denotes	24
T14740	5443-5445	11793024	denotes	25
T59756	5446-5448	11916956	denotes	26
T36865	5449-5451	12107756	denotes	27
T61136	5452-5454	12032643	denotes	28
T94019	5455-5457	12574109	denotes	29
T26328	5458-5460	15111510	denotes	30
T54337	28076-28077	9529258	denotes	2
T19212	30517-30518	9529258	denotes	2
T89333	31822-31824	11557984	denotes	18
T51674	31825-31827	11557972	denotes	19
T71039	31828-31830	12754525	denotes	20
T29841	31831-31833	15107844	denotes	21
T81808	35274-35276	10669761	denotes	31
T14109	38430-38432	12107756	denotes	27
T97479	38433-38435	15111510	denotes	30
T47443	38517-38519	12808457	denotes	22
T31037	38520-38522	12832613	denotes	23
T25796	43617-43618	12588810	denotes	6
T39414	43813-43815	12832613	denotes	23
T57349	43816-43818	15100410	denotes	32
T50815	46110-46111	9529258	denotes	2
T42321	48495-48497	14729567	denotes	33
T83049	49530-49532	11916956	denotes	26
T54981	50151-50153	14960743	denotes	24
T23967	50154-50156	12750520	denotes	34
T62149	50576-50578	15107844	denotes	21
T60801	50579-50581	11306606	denotes	35
T9964	50582-50584	12847522	denotes	36
T6089	52147-52149	15454086	denotes	37
T55195	53804-53806	14585956	denotes	38
T28920	59779-59781	12067905	denotes	39
T75921	61184-61186	2808399	denotes	40
T39784	61376-61378	15456881	denotes	41
T21106	61912-61914	15241186	denotes	42
T74302	62450-62452	8967442	denotes	43
T30502	62871-62873	9746314	denotes	44
T92611	64222-64224	11306606	denotes	35
T37367	65004-65006	10441518	denotes	45
T41842	65610-65612	11018072	denotes	10
T20004	65902-65904	14578206	denotes	46
T78845	66431-66433	10893242	denotes	47
T25998	66618-66620	10893242	denotes	47
T64490	66709-66711	12618083	denotes	48
T70594	67358-67360	10864938	denotes	49
T3712	68417-68419	12123606	denotes	50
T28425	72716-72718	10487771	denotes	51
T45354	72842-72844	1832775	denotes	52
T17303	73481-73483	9612396	denotes	53
T83023	73786-73788	10516264	denotes	54

biosemtest

Id	Subject	Object	Predicate	Lexical cue
T2557	3532-3540	UMLS/C0015259	denotes	fasting
T2558	2453-2463	UMLS/C1706057	denotes	grator of
T2559	3532-3540	UMLS/C1522704	denotes	fasting
T2560	5879-5887	UMLS/C1880274	denotes	r studie
T2561	3755-3762	UMLS/C0947630	denotes	ate tha
T2562	4096-4103	UMLS/C0947630	denotes	enic an
T2563	4465-4472	UMLS/C0947630	denotes	cardia
T2564	5145-5152	UMLS/C0947630	denotes	ered ex
T2565	5513-5520	UMLS/C0947630	denotes	vide co
T2566	5913-5920	UMLS/C0947630	denotes	trate t
T2567	3111-3119	UMLS/C0015272	denotes	a tissue
T2568	3716-3721	UMLS/C1880279	denotes	esult
T2569	3122-3128	UMLS/C1547928	denotes	riched
T2570	3390-3397	UMLS/C1547928	denotes	high-c
T2571	5987-5995	UMLS/C1619636	denotes	ing mito
T2572	3594-3606	UMLS/C0941132	denotes	suggest that
T2573	2656-2661	UMLS/C0717551	denotes	two-
T2574	1969-1971	UMLS/C0319022	denotes	to
T2575	3213-3215	UMLS/C0319022	denotes	se
T2576	3800-3802	UMLS/C0319022	denotes	ch
T2577	4915-4917	UMLS/C0319022	denotes	og
T2578	5071-5073	UMLS/C0319022	denotes	at
T2579	5413-5415	UMLS/C0319022	denotes	,
T2580	5531-5533	UMLS/C0319022	denotes	id
T2581	5809-5811	UMLS/C0319022	denotes	d
T2582	6221-6223	UMLS/C0319022	denotes	li
T2583	2656-2661	UMLS/C1478000	denotes	two-
T2584	2175-2185	UMLS/C0700114	denotes	coordinate
T2585	2656-2661	UMLS/C1000655	denotes	two-
T2586	4070-4076	UMLS/C1705190	denotes	pressi
T2587	2656-2661	UMLS/C1000654	denotes	two-
T2588	2285-2298	UMLS/C0334094	denotes	proliferation
T2589	6198-6209	UMLS/C1548787	denotes	tress durin
T2590	5689-5700	UMLS/C0019868	denotes	enesis, dev
T2591	3594-3606	UMLS/C0557985	denotes	suggest that
T2592	5764-5773	UMLS/C1578437	denotes	n strateg
T2593	2656-2661	UMLS/C2668657	denotes	two-
T2594	5764-5773	UMLS/C1578436	denotes	n strateg
T2595	3755-3762	UMLS/C1880229	denotes	ate tha
T2596	4096-4103	UMLS/C1880229	denotes	enic an
T2597	4465-4472	UMLS/C1880229	denotes	cardia
T2598	5145-5152	UMLS/C1880229	denotes	ered ex
T2599	5513-5520	UMLS/C1880229	denotes	vide co
T2600	5913-5920	UMLS/C1880229	denotes	trate t
T2601	5987-5995	UMLS/C1546857	denotes	ing mito
T2602	2872-2875	UMLS/C1428919	denotes	3]
T2603	2656-2661	UMLS/C1012742	denotes	two-
T2604	2269-2279	UMLS/C1524026	denotes	metabolism
T2605	5679-5688	UMLS/C1524026	denotes	drial bio
T2606	6152-6161	UMLS/C1524026	denotes	nd for ap
T2607	4458-4463	UMLS/C1705160	denotes	prima
T2608	2656-2661	UMLS/C0561725	denotes	two-
T2609	5435-5442	UMLS/C0028754	denotes	abetes
T2610	3331-3334	UMLS/C1412726	denotes	t,
T2611	3977-3980	UMLS/C1412726	denotes	rac
T2612	4271-4300	UP/Q16656	denotes	y factors 1 and 2 (NRF-1 and
T2613	2656-2661	UMLS/C1004374	denotes	two-
T2614	4271-4300	UMLS/C1565068	denotes	y factors 1 and 2 (NRF-1 and
T2615	6000-6008	UMLS/C0678804	denotes	rial bio
T2616	2269-2279	UMLS/C0025519	denotes	metabolism
T2617	2269-2279	UMLS/C0025520	denotes	metabolism
T2618	2186-2196	UMLS/C0017262	denotes	expression
T2619	3138-3148	UMLS/C0017262	denotes	n pattern
T2620	3444-3454	UMLS/C0017262	denotes	f the gene
T2621	4085-4095	UMLS/C0017262	denotes	s in adipo
T2622	4656-4666	UMLS/C0017262	denotes	α in skele
T2623	5177-5187	UMLS/C0017262	denotes	wnstream m
T2624	3989-4001	UMLS/C0687133	denotes	h the nuclea
T2625	2656-2661	UMLS/C0006837	denotes	two-
T2626	5987-5995	UMLS/C1556066	denotes	ing mito
T2627	4371-4374	UMLS/C1706198	denotes	l r
T2628	5091-5094	UMLS/C1706198	denotes	ene
T2629	3716-3721	UMLS/C0178499	denotes	esult
T2630	4070-4076	UMLS/C0457385	denotes	pressi
T2631	2845-2870	UP/Q6NZN1	denotes	related coactivator (PRC)
T2632	5534-5538	UMLS/C0011008	denotes	nce
T2633	3697-3702	UMLS/C1546701	denotes	nce,
T2634	2673-2679	UMLS/C1705053	denotes	n for
T2635	4533-4548	UMLS/C0025936	denotes	ve demonstrated
T2636	4700-4715	UMLS/C0025936	denotes	gers mitochondr
T2637	2656-2661	UMLS/C1006970	denotes	two-
T2638	5728-5739	UMLS/C1527148	denotes	y be addres
T2639	2545-2553	UMLS/C0178539	denotes	ular ene
T2640	3024-3032	UMLS/C0178539	denotes	energy
T2641	2833-2843	UMLS/C1550043	denotes	fied, PGC-
T2642	2796-2806	UMLS/C1524062	denotes	onal PGC-1
T2643	2656-2661	UMLS/C0319878	denotes	two-
T2644	2656-2661	UMLS/C0319882	denotes	two-
T2645	2656-2661	UMLS/C0319880	denotes	two-
T2646	3755-3762	UMLS/C0008976	denotes	ate tha
T2647	4096-4103	UMLS/C0008976	denotes	enic an
T2648	4465-4472	UMLS/C0008976	denotes	cardia
T2649	5145-5152	UMLS/C0008976	denotes	ered ex
T2650	5513-5520	UMLS/C0008976	denotes	vide co
T2651	5913-5920	UMLS/C0008976	denotes	trate t
T2652	3755-3762	UMLS/C0008972	denotes	ate tha
T2653	4096-4103	UMLS/C0008972	denotes	enic an
T2654	4465-4472	UMLS/C0008972	denotes	cardia
T2655	5145-5152	UMLS/C0008972	denotes	ered ex
T2656	5513-5520	UMLS/C0008972	denotes	vide co
T2657	5913-5920	UMLS/C0008972	denotes	trate t
T2658	1981-1988	UMLS/C1880371	denotes	diverse
T2659	2389-2398	UMLS/C1879547	denotes	activated
T2660	3900-3909	UMLS/C1879547	denotes	anscripti
T2661	4178-4187	UMLS/C1879547	denotes	drial bio
T2662	5534-5538	UMLS/C0237553	denotes	nce
T2663	4223-4228	UMLS/C0441833	denotes	tion
T2664	3467-3475	UMLS/C1547699	denotes	-1α is r
T2665	2640-2650	UMLS/C1880355	denotes	vered in a
T2666	2656-2661	UMLS/C1932574	denotes	two-
T2667	2186-2196	UMLS/C0185117	denotes	expression
T2668	3138-3148	UMLS/C0185117	denotes	n pattern
T2669	3444-3454	UMLS/C0185117	denotes	f the gene
T2670	4085-4095	UMLS/C0185117	denotes	s in adipo
T2671	4656-4666	UMLS/C0185117	denotes	α in skele
T2672	5177-5187	UMLS/C0185117	denotes	wnstream m
T2673	3697-3702	UMLS/C1556143	denotes	nce,
T2674	2673-2679	UMLS/C0199230	denotes	n for
T2675	3487-3494	UMLS/C1637379	denotes	ed by c
T2676	3863-3874	UMLS/C1546767	denotes	acity. Firs
T2677	3594-3606	UMLS/C1554188	denotes	suggest that
T2678	6133-6137	UMLS/C0035820	denotes	f mu
T2679	2656-2661	UMLS/C0319895	denotes	two-
T2680	3356-3371	UMLS/C1546780	denotes	uscle, and kidn
T2681	4681-4696	UMLS/C1546780	denotes	ransgenic mice
T2682	5247-5262	UMLS/C1546780	denotes	th insulin resi
T2683	2518-2541	UMLS/C1158770	denotes	scriptional control of
T2684	3546-3553	UMLS/C0015663	denotes	9,10,11
T2685	4271-4300	UP/Q62792	denotes	y factors 1 and 2 (NRF-1 and
T2686	2320-2326	UMLS/C1552961	denotes	points
T2687	2656-2661	UMLS/C0319899	denotes	two-
T2688	3697-3702	UMLS/C1552960	denotes	nce,
T2689	3356-3371	UMLS/C0242692	denotes	uscle, and kidn
T2690	4681-4696	UMLS/C0242692	denotes	ransgenic mice
T2691	5247-5262	UMLS/C0242692	denotes	th insulin resi
T2692	2684-2689	UMLS/C0678579	denotes	adip
T2693	3875-3883	UMLS/C1516240	denotes	, PGC-1α
T2694	4831-4844	UMLS/C0242697	denotes	ectively, the
T2695	5169-5176	UMLS/C0205349	denotes	α and d
T2696	4048-4055	UMLS/C0279175	denotes	[2]. Se
T2697	6133-6137	UMLS/C1705811	denotes	f mu
T2698	2656-2661	UMLS/C1018545	denotes	two-
T2699	6133-6137	UMLS/C1705810	denotes	f mu
T2700	6133-6137	UMLS/C1705812	denotes	f mu
T2701	2698-2706	UMLS/C0205369	denotes	fic fact
T2702	6133-6137	UMLS/C1705809	denotes	f mu
T2703	3216-3224	UMLS/C0442808	denotes	the dema
T2704	5020-5028	UMLS/C0205373	denotes	. PGC-1α
T2705	3755-3762	UMLS/C0557651	denotes	ate tha
T2706	4096-4103	UMLS/C0557651	denotes	enic an
T2707	4465-4472	UMLS/C0557651	denotes	cardia
T2708	5145-5152	UMLS/C0557651	denotes	ered ex
T2709	5513-5520	UMLS/C0557651	denotes	vide co
T2710	5913-5920	UMLS/C0557651	denotes	trate t
T2711	3216-3224	UMLS/C0442805	denotes	the dema
T2712	5325-5333	UMLS/C1883712	denotes	polymorp
T2713	2656-2661	UMLS/C1482616	denotes	two-
T2714	4070-4076	UMLS/C0565930	denotes	pressi
T2715	4271-4300	UMLS/C1417846	denotes	y factors 1 and 2 (NRF-1 and
T2716	4441-4452	UMLS/C0598312	denotes	hird, studi
T2717	3356-3371	UMLS/C1550659	denotes	uscle, and kidn
T2718	4681-4696	UMLS/C1550659	denotes	ransgenic mice
T2719	5247-5262	UMLS/C1550659	denotes	th insulin resi
T2720	3789-3799	UMLS/C0205410	denotes	romote mit
T2721	4904-4914	UMLS/C0205410	denotes	hondrial b
T2722	6000-6008	UMLS/C0439567	denotes	rial bio
T2723	2833-2843	UMLS/C0205396	denotes	fied, PGC-
T2724	3716-3721	UMLS/C1549548	denotes	esult
T2725	4761-4770	UMLS/C1522492	denotes	ndrial-ri
T2726	2573-2582	UMLS/C1552866	denotes	uding mit
T2727	4261-4270	UMLS/C1552866	denotes	respirato
T2728	6019-6028	UMLS/C1552866	denotes	wever, ou
T2729	2656-2661	UMLS/C0036025	denotes	two-
T2730	3716-3721	UMLS/C1626935	denotes	esult
T2731	4223-4228	UMLS/C1552839	denotes	tion
T2732	2038-2047	UMLS/C1719822	denotes	following
T2733	3885-3890	UMLS/C0205435	denotes	ctiva
T2734	3532-3540	UMLS/C0452240	denotes	fasting
T2735	4070-4076	UMLS/C0205436	denotes	pressi
T2736	2749-2765	UMLS/C0206588	denotes	ar receptor PPAR
T2737	4458-4463	UMLS/C0205437	denotes	prima
T2738	3697-3702	UMLS/C1550648	denotes	nce,
T2739	5752-5755	UMLS/C0006823	denotes	s-o
T2740	5745-5751	UMLS/C1621966	denotes	ing lo
T2741	4371-4374	UMLS/C1554080	denotes	l r
T2742	5091-5094	UMLS/C1554080	denotes	ene
T2743	3184-3195	UMLS/C0205463	denotes	ic conditio
T2744	3647-3658	UMLS/C0205463	denotes	ntrol of en
T2745	2792-2795	UMLS/C0205448	denotes	dit
T2746	2336-2363	UMLS/C1336776	denotes	transcriptional coactivator
T2747	2927-2954	UMLS/C1336776	denotes	ptional coactivator of nucl
T2748	3716-3721	UMLS/C1550601	denotes	esult
T2749	5817-5820	UMLS/C0444930	denotes	ara
T2750	3594-3606	UMLS/C0302523	denotes	suggest that
T2751	2175-2185	UMLS/C0427184	denotes	coordinate
T2752	6183-6189	UMLS/C0178784	denotes	o phys
T2753	4048-4055	UMLS/C0040128	denotes	[2]. Se
T2754	4078-4084	UMLS/C0441722	denotes	studi
T2755	4649-4655	UMLS/C0441722	denotes	f PGC-
T2756	4048-4055	UMLS/C0040132	denotes	[2]. Se
T2757	4761-4770	UMLS/C0439634	denotes	ndrial-ri
T2758	4476-4483	UMLS/C0439631	denotes	ocytes
T2759	5987-5995	UMLS/C1514873	denotes	ing mito
T2760	4223-4228	UMLS/C0439745	denotes	tion
T2761	3594-3606	UMLS/C0700325	denotes	suggest that
T2762	4801-4810	UMLS/C0311404	denotes	tch”) mus
T2763	5095-5102	UMLS/C0996514	denotes	[18,19
T2764	5679-5688	UMLS/C0311400	denotes	drial bio
T2765	6152-6161	UMLS/C0311400	denotes	nd for ap
T2766	3755-3762	UMLS/C1705923	denotes	ate tha
T2767	4096-4103	UMLS/C1705923	denotes	enic an
T2768	4465-4472	UMLS/C1705923	denotes	cardia
T2769	5145-5152	UMLS/C1705923	denotes	ered ex
T2770	5513-5520	UMLS/C1705923	denotes	vide co
T2771	5913-5920	UMLS/C1705923	denotes	trate t
T2772	3216-3224	UMLS/C0205217	denotes	the dema
T2773	5817-5820	UMLS/C1522314	denotes	ara
T2774	2656-2661	UMLS/C1002875	denotes	two-
T2775	2656-2661	UMLS/C1002872	denotes	two-
T2776	4476-4483	UMLS/C0205225	denotes	ocytes
T2777	3716-3721	UMLS/C1705938	denotes	esult
T2778	6145-6151	UMLS/C2347086	denotes	rgans
T2779	2656-2661	UMLS/C1005067	denotes	two-
T2780	2108-2117	UMLS/C1710082	denotes	signaling
T2781	3729-3736	UMLS/C0332294	denotes	rexpres
T2782	4871-4878	UMLS/C0332294	denotes	C-1α is
T2783	3729-3736	UMLS/C1274040	denotes	rexpres
T2784	4871-4878	UMLS/C1274040	denotes	C-1α is
T2785	4011-4036	UMLS/C0887829	denotes	receptors PPARγ and thyro
T2786	1996-2003	UMLS/C0441516	denotes	demands
T2787	3229-3235	UMLS/C0441516	denotes	r mito
T2788	3164-3170	UMLS/C0205250	denotes	ducibl
T2789	2656-2661	UMLS/C1005069	denotes	two-
T2790	2813-2827	UMLS/C1611821	denotes	members were
T2791	5534-5538	UMLS/C2348077	denotes	nce
T2792	6124-6132	UMLS/C1552746	denotes	unction
T2793	3171-3180	UMLS/C0205263	denotes	by physi
T2794	3495-3502	UMLS/C0205263	denotes	ld expo
T2795	2573-2582	UMLS/C2700399	denotes	uding mit
T2796	4261-4270	UMLS/C2700399	denotes	respirato
T2797	6019-6028	UMLS/C2700399	denotes	wever, ou
T2798	4253-4260	UMLS/C0599894	denotes	nuclear
T2799	5228-5234	UMLS/C0599894	denotes	muscle
T2800	5870-5878	UMLS/C0599894	denotes	gene. O
T2801	5879-5887	UMLS/C1704790	denotes	r studie
T2802	2698-2706	UMLS/C1552740	denotes	fic fact
T2803	2656-2661	UMLS/C1002920	denotes	two-
T2804	2163-2170	UMLS/C0332298	denotes	control
T2805	3659-3666	UMLS/C0332298	denotes	rgy met
T2806	5009-5016	UMLS/C0332298	denotes	metabo
T2807	5521-5530	UMLS/C1552738	denotes	pelling e
T2808	6124-6132	UMLS/C1511545	denotes	unction
T2809	5972-5975	UMLS/C1518422	denotes	iab
T2810	5419-5434	UMLS/C0332281	denotes	rtension, and d
T2811	2038-2047	UMLS/C0332282	denotes	following
T2812	4918-4923	UMLS/C0004379	denotes	nesis
T2813	5235-5243	UMLS/C1705987	denotes	of human
T2814	4504-4511	UMLS/C0010453	denotes	hearts
T2815	2656-2661	UMLS/C1504647	denotes	two-
T2816	2038-2047	UMLS/C0332283	denotes	following
T2817	2573-2582	UMLS/C0332257	denotes	uding mit
T2818	4261-4270	UMLS/C0332257	denotes	respirato
T2819	6019-6028	UMLS/C0332257	denotes	wever, ou
T2820	3729-3736	UMLS/C1546471	denotes	rexpres
T2821	4871-4878	UMLS/C1546471	denotes	C-1α is
T2822	5462-5470	UMLS/C0011849	denotes	The gai
T2823	5462-5470	UMLS/C0011847	denotes	The gai
T2824	2673-2679	UMLS/C1710031	denotes	n for
T2825	2048-2053	UMLS/C1550722	denotes	birth
T2826	6145-6151	UMLS/C0205307	denotes	rgans
T2827	3207-3212	UMLS/C0205309	denotes	incre
T2828	2138-2157	UMLS/C1514829	denotes	regulatory pathways
T2829	2673-2679	UMLS/C0430054	denotes	n for
T2830	2845-2870	UP/Q5VV67	denotes	related coactivator (PRC)
T2831	2481-2491	UMLS/C1704735	denotes	latory cir
T2832	2908-2914	UMLS/C1519269	denotes	s a di
T2833	6115-6121	UMLS/C1519269	denotes	taboli
T2834	1972-1976	UMLS/C0556656	denotes	meet
T2835	5169-5176	UMLS/C0221099	denotes	α and d
T2836	2656-2661	UMLS/C1054380	denotes	two-
T2837	2163-2170	UMLS/C1882979	denotes	control
T2838	3659-3666	UMLS/C1882979	denotes	rgy met
T2839	5009-5016	UMLS/C1882979	denotes	metabo
T2840	2656-2661	UMLS/C1054381	denotes	two-
T2841	5830-5841	UMLS/C1272684	denotes	ice with ta
T2842	4716-4724	UMLS/C1444748	denotes	al proli
T2843	2833-2843	UMLS/C1551388	denotes	fied, PGC-
T2844	2656-2661	UMLS/C0319605	denotes	two-
T2845	3989-4001	UMLS/C1704675	denotes	h the nuclea
T2846	3546-3553	UMLS/C0456962	denotes	9,10,11
T2847	6145-6151	UMLS/C1551394	denotes	rgans
T2848	5817-5820	UMLS/C1272693	denotes	ara
T2849	5817-5820	UMLS/C1561490	denotes	ara
T2850	6124-6132	UMLS/C1551396	denotes	unction
T2851	5203-5213	UMLS/C0522506	denotes	get pathwa
T2852	2981-2989	UMLS/C0597357	denotes	transcr
T2853	4056-4064	UMLS/C0597357	denotes	ond, for
T2854	3196-3206	UMLS/C0009647	denotes	s known to
T2855	2656-2661	UMLS/C0319600	denotes	two-
T2856	4070-4076	UMLS/C1561503	denotes	pressi
T2857	3254-3257	UMLS/C0001480	denotes	at
T2858	2019-2028	UMLS/C0024660	denotes	mammalian
T2859	2311-2319	UMLS/C0332120	denotes	evidence
T2860	3706-3714	UMLS/C0332120	denotes	d on the
T2861	4957-4965	UMLS/C0332120	denotes	PGC-1α i
T2862	5558-5566	UMLS/C0332120	denotes	le of re
T2863	3129-3137	UMLS/C0359583	denotes	expressi
T2864	3297-3305	UMLS/C0359583	denotes	n brown
T2865	6145-6151	UMLS/C1550457	denotes	rgans
T2866	4070-4076	UMLS/C2348168	denotes	pressi
T2867	5539-5546	UMLS/C0359589	denotes	hat PGC
T2868	3254-3257	UMLS/C1705556	denotes	at
T2869	4223-4228	UMLS/C1522242	denotes	tion
T2870	5745-5751	UMLS/C0018270	denotes	ing lo
T2871	5278-5309	UMLS/C0342335	denotes	tes [22,23,24]. In addition, si
T2872	6145-6151	UMLS/C1704701	denotes	rgans
T2873	5095-5102	UMLS/C0205054	denotes	[18,19
T2874	3607-3614	UMLS/C1705535	denotes	PGC-1α
T2875	3594-3606	UMLS/C1964257	denotes	suggest that
T2876	2656-2661	UMLS/C0319629	denotes	two-
T2877	2915-2926	UMLS/C1879741	denotes	ect transcr
T2878	4223-4228	UMLS/C1561557	denotes	tion
T2879	3594-3606	UMLS/C1548358	denotes	suggest that
T2880	5534-5538	UMLS/C1547350	denotes	nce
T2881	5756-5760	UMLS/C0205171	denotes	-fun
T2882	2090-2098	UMLS/C1947935	denotes	involves
T2883	2232-2240	UMLS/C1947935	denotes	involved
T2884	2502-2510	UMLS/C1947935	denotes	lved in
T2885	3012-3020	UMLS/C1947935	denotes	in cell
T2886	3631-3639	UMLS/C1947935	denotes	e physio
T2887	3697-3702	UMLS/C1548328	denotes	nce,
T2888	3309-3329	UMLS/C0006298	denotes	ose tissue (BAT), he
T2889	3331-3334	UMLS/C0006298	denotes	t,
T2890	3977-3980	UMLS/C0006298	denotes	rac
T2891	2304-2310	UMLS/C0332185	denotes	Recent
T2892	4950-4956	UMLS/C0332185	denotes	icates
T2893	5138-5144	UMLS/C0332185	denotes	own al
T2894	6124-6132	UMLS/C1547308	denotes	unction
T2895	5534-5538	UMLS/C1548309	denotes	nce
T2896	3764-3772	UMLS/C1444656	denotes	PGC-1α i
T2897	4879-4887	UMLS/C1444656	denotes	sufficie
T2898	6077-6085	UMLS/C1444656	denotes	erves a
T2899	2990-3011	UMLS/C0040648	denotes	ption factors involve
T2900	4232-4252	UMLS/C0040648	denotes	or targets including
T2901	2656-2661	UMLS/C0997362	denotes	two-
T2902	2656-2661	UMLS/C0997360	denotes	two-
T2903	2656-2661	UMLS/C0997364	denotes	two-
T2904	2656-2661	UMLS/C0997363	denotes	two-
T2905	2122-2137	UMLS/C0040649	denotes	transcriptional
T2906	3914-3927	UMLS/C0040649	denotes	mitochondria
T2907	4423-4436	UMLS/C0040649	denotes	replication [
T2908	2656-2661	UMLS/C0997356	denotes	two-
T2909	2656-2661	UMLS/C0997355	denotes	two-
T2910	6124-6132	UMLS/C1579038	denotes	unction
T2911	2656-2661	UMLS/C0997372	denotes	two-
T2912	4725-4752	UMLS/C2259852	denotes	eration and the formation o
T2914	3697-3702	UMLS/C0205132	denotes	nce,
T2915	2656-2661	UMLS/C0997368	denotes	two-
T2916	5764-5773	UMLS/C1547327	denotes	n strateg
T2917	2656-2661	UMLS/C0997370	denotes	two-
T2918	2656-2661	UMLS/C0319552	denotes	two-
T2919	2656-2661	UMLS/C0319554	denotes	two-
T2920	2090-2098	UMLS/C1314939	denotes	involves
T2921	2232-2240	UMLS/C1314939	denotes	involved
T2922	2502-2510	UMLS/C1314939	denotes	lved in
T2923	3012-3020	UMLS/C1314939	denotes	in cell
T2924	3631-3639	UMLS/C1314939	denotes	e physio
T2925	3196-3206	UMLS/C0348080	denotes	s known to
T2926	2656-2661	UMLS/C1016138	denotes	two-
T2927	4484-4500	UMLS/C0225828	denotes	n culture and in
T2928	4131-4145	UMLS/C1512977	denotes	nes demonstrat
T2929	4504-4511	UMLS/C0430400	denotes	hearts
T2930	3755-3762	UMLS/C2349977	denotes	ate tha
T2931	4096-4103	UMLS/C2349977	denotes	enic an
T2932	4465-4472	UMLS/C2349977	denotes	cardia
T2933	5145-5152	UMLS/C2349977	denotes	ered ex
T2934	5513-5520	UMLS/C2349977	denotes	vide co
T2935	5913-5920	UMLS/C2349977	denotes	trate t
T2936	6124-6132	UMLS/C1547298	denotes	unction
T2937	4271-4300	UP/Q9WU00	denotes	y factors 1 and 2 (NRF-1 and
T2938	2163-2170	UMLS/C0009932	denotes	control
T2939	3659-3666	UMLS/C0009932	denotes	rgy met
T2940	5009-5016	UMLS/C0009932	denotes	metabo
T2941	3337-3342	UMLS/C1281570	denotes	w-twi
T2942	4523-4529	UMLS/C1281570	denotes	ic mic
T2943	3755-3762	UMLS/C2603343	denotes	ate tha
T2944	4096-4103	UMLS/C2603343	denotes	enic an
T2945	4465-4472	UMLS/C2603343	denotes	cardia
T2946	5145-5152	UMLS/C2603343	denotes	ered ex
T2947	5513-5520	UMLS/C2603343	denotes	vide co
T2948	5913-5920	UMLS/C2603343	denotes	trate t
T2949	4504-4511	UMLS/C2242979	denotes	hearts
T2950	4223-4228	UMLS/C1552516	denotes	tion
T2951	4011-4036	UMLS/C1753269	denotes	receptors PPARγ and thyro
T2952	2673-2679	UMLS/C0220909	denotes	n for
T2953	2673-2679	UMLS/C0220908	denotes	n for
T2954	3122-3128	UMLS/C0040300	denotes	riched
T2955	3390-3397	UMLS/C0040300	denotes	high-c
T2956	2481-2491	UMLS/C0220905	denotes	latory cir
T2957	3546-3553	UMLS/C1550565	denotes	9,10,11
T2958	2673-2679	UMLS/C1305399	denotes	n for
T2959	2872-2875	UMLS/C0008115	denotes	3]
T2960	2656-2661	UMLS/C0260215	denotes	two-
T2961	2656-2661	UMLS/C1005995	denotes	two-
T2962	2656-2661	UMLS/C0260217	denotes	two-
T2963	5745-5751	UMLS/C1457898	denotes	ing lo
T2964	3729-3736	UMLS/C1280519	denotes	rexpres
T2965	4871-4878	UMLS/C1280519	denotes	C-1α is
T2966	3716-3721	UMLS/C1704464	denotes	esult
T2967	2656-2661	UMLS/C1005990	denotes	two-
T2968	2079-2089	UMLS/C0220781	denotes	biogenesis
T2969	2610-2620	UMLS/C0220781	denotes	enesis [1,
T2970	3825-3835	UMLS/C0220781	denotes	regulate m
T2971	4202-4212	UMLS/C0220781	denotes	a group o
T2972	4621-4631	UMLS/C0220781	denotes	Lastly, f
T2973	4761-4770	UMLS/C0220781	denotes	ndrial-ri
T2974	4938-4948	UMLS/C0220781	denotes	ce also im
T2975	5716-5726	UMLS/C0220781	denotes	owth can o
T2976	6043-6053	UMLS/C0220781	denotes	cate that
T2977	2673-2679	UMLS/C1698960	denotes	n for
T2978	2471-2480	UMLS/C1521991	denotes	cular reg
T2979	2656-2661	UMLS/C0446038	denotes	two-
T2980	3149-3156	UMLS/C0449774	denotes	nd is h
T2981	2656-2661	UMLS/C0446023	denotes	two-
T2982	2656-2661	UMLS/C0446020	denotes	two-
T2983	2656-2661	UMLS/C0446021	denotes	two-
T2984	4405-4422	UMLS/C1819717	denotes	transcription and
T2985	3467-3475	UMLS/C2700640	denotes	-1α is r
T2986	6068-6076	UMLS/C2607943	denotes	PGC-1α
T2987	5879-5887	UMLS/C1511760	denotes	r studie
T2988	4504-4511	UMLS/C0220814	denotes	hearts
T2989	2554-2571	UMLS/C0014272	denotes	gy metabolism, in
T2990	3033-3050	UMLS/C0014272	denotes	etabolism [6]. PG
T2991	3670-3687	UMLS/C0014272	denotes	ism. Several line
T2992	5029-5046	UMLS/C0014272	denotes	has been shown to
T2993	5615-5632	UMLS/C0014272	denotes	e necessity of PG
T2994	3803-3810	UMLS/C0033414	denotes	ndrial
T2995	4598-4606	UMLS/C0033414	denotes	ial biog
T2996	4375-4401	UP/Q9CJ45	denotes	gulators of mitochondrial
T2997	2163-2170	UMLS/C1550141	denotes	control
T2998	3659-3666	UMLS/C1550141	denotes	rgy met
T2999	5009-5016	UMLS/C1550141	denotes	metabo
T3000	5797-5807	UMLS/C0679199	denotes	e establis
T3001	3196-3206	UMLS/C1705253	denotes	s known to
T3002	3261-3276	UMLS/C0018841	denotes	uction [2,6,7].
T3003	4326-4362	UMLS/C0965025	denotes	scription factor A (Tfam), key trans
T3004	2656-2661	UMLS/C0997660	denotes	two-
T3005	2656-2661	UMLS/C0043393	denotes	two-
T3006	2656-2661	UMLS/C0997659	denotes	two-
T3007	2656-2661	UMLS/C0043392	denotes	two-
T3008	2813-2827	UMLS/C0086282	denotes	members were
T3009	2029-2037	UMLS/C0029235	denotes	organism
T3010	6183-6189	UMLS/C0029235	denotes	o phys
T3011	5056-5059	UMLS/C2348947	denotes	sev
T3012	2597-2605	UMLS/C1705273	denotes	tion and
T3013	6162-6170	UMLS/C1705273	denotes	ropriate
T3014	5846-5859	UMLS/C1880022	denotes	d deletion of
T3015	5879-5887	UMLS/C1442161	denotes	r studie
T3016	2656-2661	UMLS/C1006506	denotes	two-
T3017	3431-3438	UMLS/C1704459	denotes	expres
T3018	2099-2107	UMLS/C0439064	denotes	multiple
T3019	6174-6182	UMLS/C0439064	denotes	ptation
T3020	1924-1943	UMLS/C1998319	denotes	functional capacity
T3021	6145-6151	UMLS/C1873497	denotes	rgans
T3022	1910-1923	UMLS/C0026237	denotes	Mitochondrial
T3023	2065-2078	UMLS/C0026237	denotes	mitochondrial
T3024	2244-2267	UMLS/C0026237	denotes	mitochondrial structure
T3025	2583-2596	UMLS/C0026237	denotes	chondrial fun
T3026	3240-3253	UMLS/C0026237	denotes	rial ATP or h
T3027	3417-3430	UMLS/C0026237	denotes	l systems. Th
T3028	3811-3824	UMLS/C0026237	denotes	iogenesis and
T3029	3849-3862	UMLS/C0026237	denotes	espiratory ca
T3030	3931-3944	UMLS/C0026237	denotes	coupling prot
T3031	4188-4201	UMLS/C0026237	denotes	enesis throug
T3032	4607-4620	UMLS/C0026237	denotes	nesis [10,16]
T3033	4924-4937	UMLS/C0026237	denotes	Recent evide
T3034	5214-5227	UMLS/C0026237	denotes	s in skeletal
T3035	5702-5715	UMLS/C0026237	denotes	opment, and g
T3036	6029-6042	UMLS/C0026237	denotes	findings ind
T3037	3337-3342	UMLS/C0018787	denotes	w-twi
T3038	4523-4529	UMLS/C0018787	denotes	ic mic
T3039	5335-5366	UMLS/C0752046	denotes	sms within the human PGC-1α gen
T3040	6133-6137	UMLS/C1704326	denotes	f mu
T3041	2163-2170	UMLS/C1547100	denotes	control
T3042	3659-3666	UMLS/C1547100	denotes	rgy met
T3043	5009-5016	UMLS/C1547100	denotes	metabo
T3044	3431-3438	UMLS/C0449913	denotes	expres
T3045	3697-3702	UMLS/C1553412	denotes	nce,
T3046	4223-4228	UMLS/C1257890	denotes	tion
T3047	2200-2207	UMLS/C0521447	denotes	nuclear
T3048	2958-2965	UMLS/C0521447	denotes	and non
T3049	1910-1923	UMLS/C0521451	denotes	Mitochondrial
T3050	2065-2078	UMLS/C0521451	denotes	mitochondrial
T3051	2583-2596	UMLS/C0521451	denotes	chondrial fun
T3052	3240-3253	UMLS/C0521451	denotes	rial ATP or h
T3053	3417-3430	UMLS/C0521451	denotes	l systems. Th
T3054	3811-3824	UMLS/C0521451	denotes	iogenesis and
T3055	3849-3862	UMLS/C0521451	denotes	espiratory ca
T3056	3931-3944	UMLS/C0521451	denotes	coupling prot
T3057	4188-4201	UMLS/C0521451	denotes	enesis throug
T3058	4607-4620	UMLS/C0521451	denotes	nesis [10,16]
T3059	4924-4937	UMLS/C0521451	denotes	Recent evide
T3060	5214-5227	UMLS/C0521451	denotes	s in skeletal
T3061	5702-5715	UMLS/C0521451	denotes	opment, and g
T3062	6029-6042	UMLS/C0521451	denotes	findings ind
T3063	5435-5442	UMLS/C1963185	denotes	abetes
T3064	3431-3438	UMLS/C1553451	denotes	expres
T3065	2108-2117	UMLS/C0037083	denotes	signaling
T3066	4078-4084	UMLS/C0443221	denotes	studi
T3067	4649-4655	UMLS/C0443221	denotes	f PGC-
T3068	2656-2661	UMLS/C0997658	denotes	two-
T3069	2320-2326	UMLS/C1553441	denotes	points
T3070	5444-5456	UMLS/C0020538	denotes	5,26,27,28,2
T3071	5830-5841	UMLS/C0443211	denotes	ice with ta
T3072	5444-5456	UMLS/C1963138	denotes	5,26,27,28,2
T3073	2656-2661	UMLS/C1621355	denotes	two-
T3074	2597-2605	UMLS/C0542341	denotes	tion and
T3075	6162-6170	UMLS/C0542341	denotes	ropriate
T3076	5752-5755	UMLS/C0344312	denotes	s-o
T3077	3885-3890	UMLS/C1279901	denotes	ctiva
T3078	3467-3475	UMLS/C0679058	denotes	-1α is r
T3079	2163-2170	UMLS/C0243148	denotes	control
T3080	3659-3666	UMLS/C0243148	denotes	rgy met
T3081	5009-5016	UMLS/C0243148	denotes	metabo
T3082	5235-5243	UMLS/C1704259	denotes	of human
T3083	6145-6151	UMLS/C0439166	denotes	rgans
T3084	2079-2089	UMLS/C0005495	denotes	biogenesis
T3085	2610-2620	UMLS/C0005495	denotes	enesis [1,
T3086	3825-3835	UMLS/C0005495	denotes	regulate m
T3087	4202-4212	UMLS/C0005495	denotes	a group o
T3088	4621-4631	UMLS/C0005495	denotes	Lastly, f
T3089	4938-4948	UMLS/C0005495	denotes	ce also im
T3090	5716-5726	UMLS/C0005495	denotes	owth can o
T3091	6043-6053	UMLS/C0005495	denotes	cate that
T3092	2656-2661	UMLS/C1499971	denotes	two-
T3093	2320-2326	UMLS/C2347617	denotes	points
T3094	2656-2661	UMLS/C1012067	denotes	two-
T3095	4405-4422	UMLS/C0012929	denotes	transcription and
T3096	4078-4084	UMLS/C0563538	denotes	studi
T3097	4649-4655	UMLS/C0563538	denotes	f PGC-
T3098	5764-5773	UMLS/C1442065	denotes	n strateg
T3099	2055-2064	UMLS/C0443281	denotes	Postnatal
T3100	5605-5614	UMLS/C0443281	denotes	owever, t
T3101	2212-2231	UMLS/C1563761	denotes	mitochondrial genes
T3102	5266-5272	UMLS/C0020156	denotes	ce and
T3103	5378-5383	UMLS/C0020156	denotes	shown
T3104	4253-4260	UMLS/C1521840	denotes	nuclear
T3105	5228-5234	UMLS/C1521840	denotes	muscle
T3106	5870-5878	UMLS/C1521840	denotes	gene. O
T3107	2656-2661	UMLS/C1012085	denotes	two-
T3108	2656-2661	UMLS/C1012081	denotes	two-
T3109	2365-2388	UMLS/C0600434	denotes	peroxisome proliferator
T3110	3863-3874	UMLS/C0521346	denotes	acity. Firs
T3111	4223-4228	UMLS/C1705428	denotes	tion
T3112	4223-4228	UMLS/C1705429	denotes	tion
T3113	3521-3531	UMLS/C0443303	denotes	ercise, an
T3114	2656-2661	UMLS/C1081415	denotes	two-
T3115	3506-3519	UMLS/C0231275	denotes	, short-term
T3116	2175-2185	UMLS/C1707511	denotes	coordinate
T3117	2656-2661	UMLS/C0524509	denotes	two-
T3118	2545-2553	UMLS/C0007634	denotes	ular ene
T3119	3024-3032	UMLS/C0007634	denotes	energy
T3120	2048-2053	UMLS/C0005615	denotes	birth
T3121	2656-2661	UMLS/C1001398	denotes	two-
T3122	2269-2279	UMLS/C1291081	denotes	metabolism
T3123	2656-2661	UMLS/C1001404	denotes	two-
T3124	3356-3371	UMLS/C1280260	denotes	uscle, and kidn
T3125	4681-4696	UMLS/C1280260	denotes	ransgenic mice
T3126	5247-5262	UMLS/C1280260	denotes	th insulin resi
T3127	2656-2661	UMLS/C1001397	denotes	two-
T3128	1996-2003	UMLS/C0699784	denotes	demands
T3129	3229-3235	UMLS/C0699784	denotes	r mito
T3130	3254-3257	UMLS/C1366832	denotes	at
T3131	1959-1968	UMLS/C0851285	denotes	regulated
T3132	3840-3848	UMLS/C0851285	denotes	ondrial
T3133	5074-5082	UMLS/C0851285	denotes	c glucon
T3134	5594-5604	UMLS/C0851285	denotes	tabolism.
T3135	3989-4001	UMLS/C1546938	denotes	h the nuclea
T3136	5764-5773	UMLS/C0376649	denotes	n strateg
T3137	2163-2170	UMLS/C2587213	denotes	control
T3138	3659-3666	UMLS/C2587213	denotes	rgy met
T3139	5009-5016	UMLS/C2587213	denotes	metabo
T3140	4141-4151	UMLS/C0007600	denotes	trated tha
T3141	4716-4724	UMLS/C0032930	denotes	al proli
T3142	6210-6220	UMLS/C0392673	denotes	postnatal
T3143	5756-5760	UMLS/C1720467	denotes	-fun
T3144	5812-5816	UMLS/C0323983	denotes	nd c
T5282	7002-7007	UMLS/C1955473	denotes	tiss
T5230	8342-8349	UMLS/C0221099	denotes	er, the
T5231	8425-8432	UMLS/C1521721	denotes	a PGC-1
T5232	7185-7192	UMLS/C0206415	denotes	re desi
T5233	8003-8008	UMLS/C0205112	denotes	tion
T5234	8074-8082	UMLS/C0522501	denotes	mutant P
T5235	8009-8019	UMLS/C0009647	denotes	nown to ma
T5236	8055-8064	UMLS/C0009647	denotes	1α in BAT
T5237	6339-6344	UMLS/C0015295	denotes	xons
T5238	6620-6624	UMLS/C0015295	denotes	3 d
T5239	6647-6652	UMLS/C0015295	denotes	s 5 a
T5240	7273-7277	UMLS/C0015295	denotes	rder
T5241	7346-7350	UMLS/C0015295	denotes	redi
T5242	7427-7431	UMLS/C0015295	denotes	ecte
T5243	7552-7556	UMLS/C0015295	denotes	y in
T5244	7627-7631	UMLS/C0015295	denotes	o be
T5245	6545-6554	UMLS/C0750484	denotes	irmed by
T5246	6804-6813	UMLS/C0750484	denotes	irmed usi
T5247	6332-6338	UMLS/C1880274	denotes	elete
T5248	6921-6929	UMLS/C1883468	denotes	ble tran
T5249	7840-7848	UMLS/C1883468	denotes	cell (Fi
T5250	7172-7179	UMLS/C0947630	denotes	CR prim
T5251	7563-7570	UMLS/C1514468	denotes	−/− mic
T5252	6332-6338	UMLS/C1608885	denotes	elete
T5253	6287-6292	UMLS/C1880279	denotes	ased
T5254	7008-7015	UMLS/C1547928	denotes	es in P
T5255	6610-6616	UMLS/C1314792	denotes	ed an
T5256	7073-7085	UMLS/C0392762	denotes	ve RT-PCR wa
T5257	6329-6331	UMLS/C0319022	denotes	o
T5258	7106-7108	UMLS/C0319022	denotes	e
T5259	7207-7209	UMLS/C0319022	denotes	a
T5260	7302-7304	UMLS/C0319022	denotes	in
T5261	7375-7377	UMLS/C0319022	denotes	n
T5262	7667-7669	UMLS/C0319022	denotes	ct
T5263	8071-8073	UMLS/C0319022	denotes	er
T5264	7495-7498	UMLS/C0005341	denotes	ure
T5265	7744-7747	UMLS/C0005341	denotes	ce,
T5266	6580-6594	UMLS/C0162326	denotes	sequencing. Th
T5267	7912-7927	UMLS/C0949374	denotes	from BAT of PG
T5268	6278-6286	UMLS/C0027603	denotes	eomycin-
T5269	7886-7891	UMLS/C0444667	denotes	unpub
T5270	7892-7896	UMLS/C1269647	denotes	ishe
T5271	7172-7179	UMLS/C1880229	denotes	CR prim
T5272	8315-8318	UMLS/C1428919	denotes	e (
T5273	6766-6778	UMLS/C0040722	denotes	smission of
T5274	7389-7393	UMLS/C0205171	denotes	− mi
T5275	7583-7587	UMLS/C0205171	denotes	. An
T5276	7292-7301	UMLS/C0681842	denotes	be absent
T5277	7365-7374	UMLS/C0681842	denotes	ent only
T5278	7657-7666	UMLS/C0681842	denotes	) was det
T5279	7473-7476	UMLS/C0006298	denotes	ot
T5280	7970-7973	UMLS/C0006298	denotes	esp
T5281	8119-8122	UMLS/C0006298	denotes	by
T5283	8269-8274	UMLS/C1955473	denotes	ignif
T5284	6545-6554	UMLS/C1456348	denotes	irmed by
T5285	6804-6813	UMLS/C1456348	denotes	irmed usi
T5286	6395-6400	UMLS/C0441471	denotes	ent r
T5287	6535-6540	UMLS/C0441471	denotes	t was
T5288	7473-7476	UMLS/C1412726	denotes	ot
T5289	7970-7973	UMLS/C1412726	denotes	esp
T5290	8119-8122	UMLS/C1412726	denotes	by
T5291	6741-6751	UMLS/C0002520	denotes	o acid 255
T5292	6610-6616	UMLS/C0678227	denotes	ed an
T5293	7858-7865	UMLS/C0033684	denotes	r nucle
T5294	8147-8155	UMLS/C0033684	denotes	npublish
T5295	7480-7489	UMLS/C1883559	denotes	1α−/− mic
T5296	7799-7809	UMLS/C1444656	denotes	PGC-1α pro
T5297	7220-7226	UMLS/C0205147	denotes	the PG
T5298	7308-7314	UMLS/C0332197	denotes	-1α−/−
T5299	6854-6857	UMLS/C0032520	denotes	(un
T5300	7181-7184	UMLS/C0032520	denotes	s w
T5301	7002-7007	UMLS/C1556044	denotes	tiss
T5302	8269-8274	UMLS/C1556044	denotes	ignif
T5303	6545-6554	UMLS/C0521093	denotes	irmed by
T5304	6804-6813	UMLS/C0521093	denotes	irmed usi
T5305	6610-6616	UMLS/C1524003	denotes	ed an
T5306	7892-7896	UMLS/C1704653	denotes	ishe
T5307	8094-8104	UMLS/C0017262	denotes	ns were al
T5308	8232-8242	UMLS/C0017262	denotes	ly members
T5309	8009-8019	UMLS/C0348080	denotes	nown to ma
T5310	8055-8064	UMLS/C0348080	denotes	1α in BAT
T5311	6287-6292	UMLS/C0178499	denotes	ased
T5312	7956-7964	UMLS/C1546680	denotes	itions o
T5313	8182-8203	UMLS/C0949466	denotes	n of the genes encodi
T5314	6726-6737	UMLS/C1692758	denotes	ination at
T5315	7172-7179	UMLS/C2349977	denotes	CR prim
T5316	6332-6338	UMLS/C1548394	denotes	elete
T5317	8124-8131	UMLS/C0547044	denotes	estern
T5318	6308-6314	UMLS/C1705099	denotes	ector
T5319	6992-6997	UMLS/C1281570	denotes	and
T5320	7463-7468	UMLS/C1281570	denotes	(WT)
T5321	8353-8358	UMLS/C1281570	denotes	esult
T5322	7172-7179	UMLS/C2603343	denotes	CR prim
T5323	8401-8409	UMLS/C1883357	denotes	eting ev
T5324	6558-6575	UMLS/C0005862	denotes	hern blotting and
T5325	6820-6837	UMLS/C0005862	denotes	hern blotting (Fi
T5326	6971-6988	UMLS/C0005861	denotes	lot analysis in h
T5327	7531-7533	UMLS/C1416886	denotes	od
T5328	7619-7621	UMLS/C1416886	denotes	di
T5329	7008-7015	UMLS/C0040300	denotes	es in P
T5330	8315-8318	UMLS/C0008115	denotes	e (
T5331	6308-6314	UMLS/C0442335	denotes	ector
T5332	6786-6792	UMLS/C0596988	denotes	nt all
T5333	7819-7825	UMLS/C0596988	denotes	ot det
T5334	8132-8138	UMLS/C0596988	denotes	lot an
T5335	7172-7179	UMLS/C0008976	denotes	CR prim
T5336	7172-7179	UMLS/C0008972	denotes	CR prim
T5337	6401-6409	UMLS/C1280519	denotes	sulted i
T5338	6701-6710	UMLS/C1280519	denotes	lting in
T5339	6906-6914	UMLS/C1280519	denotes	ted in a
T5340	8417-8424	UMLS/C1280519	denotes	lted in
T5341	6287-6292	UMLS/C1704464	denotes	ased
T5342	6959-6967	UMLS/C1511790	denotes	ted by R
T5343	7451-7459	UMLS/C1511790	denotes	f wild-t
T5344	7704-7712	UMLS/C1511790	denotes	s greatl
T5345	8256-8264	UMLS/C1547699	denotes	RC, was
T5346	6360-6366	UMLS/C0026809	denotes	urine
T5347	7892-7896	UMLS/C1948049	denotes	ishe
T5348	6360-6366	UMLS/C0026802	denotes	urine
T5349	8425-8432	UMLS/C1317973	denotes	a PGC-1
T5350	6930-6940	UMLS/C1519595	denotes	cript that
T5351	7247-7257	UMLS/C1519595	denotes	containing
T5352	7826-7836	UMLS/C1519595	denotes	cted in wh
T5353	7928-7936	UMLS/C0185115	denotes	-1α−/− m
T5354	6521-6534	UMLS/C0034865	denotes	mbination eve
T5355	6627-6638	UMLS/C0332597	denotes	ication bet
T5356	6558-6575	UMLS/C1148472	denotes	hern blotting and
T5357	6820-6837	UMLS/C1148472	denotes	hern blotting (Fi
T5358	6360-6366	UMLS/C0591833	denotes	urine
T5359	8094-8104	UMLS/C0185117	denotes	ns were al
T5360	8232-8242	UMLS/C0185117	denotes	ly members
T5361	7892-7896	UMLS/C1136359	denotes	ishe
T5362	6846-6848	UMLS/C0450345	denotes	an
T5363	7117-7125	UMLS/C0220825	denotes	he effic
T5364	7689-7698	UMLS/C0017431	denotes	/− mice,
T5365	7292-7301	UMLS/C1882327	denotes	be absent
T5366	7365-7374	UMLS/C1882327	denotes	ent only
T5367	7657-7666	UMLS/C1882327	denotes	) was det
T5368	8256-8264	UMLS/C2700640	denotes	RC, was
T5369	6502-6504	UMLS/C0450344	denotes	T
T5370	6545-6554	UMLS/C1446409	denotes	irmed by
T5371	6804-6813	UMLS/C1446409	denotes	irmed usi
T5372	6690-6700	UMLS/C0079380	denotes	eshift res
T5373	7220-7226	UMLS/C0017446	denotes	the PG
T5374	7563-7570	UMLS/C1550506	denotes	−/− mic
T5375	7220-7226	UMLS/C1514562	denotes	the PG
T5376	6666-6673	UMLS/C1706214	denotes	tes a c
T5377	7531-7533	UMLS/C1442449	denotes	od
T5378	7619-7621	UMLS/C1442449	denotes	di
T5379	8342-8349	UMLS/C0205349	denotes	er, the
T5380	8425-8432	UMLS/C0183683	denotes	a PGC-1
T5381	8395-8400	UMLS/C1883727	denotes	e tar
T5382	8009-8019	UMLS/C1705253	denotes	nown to ma
T5383	8055-8064	UMLS/C1705253	denotes	1α in BAT
T5384	6450-6459	UMLS/C1883719	denotes	rtion of
T5385	6511-6520	UMLS/C1883719	denotes	rtion/rec
T5386	6600-6609	UMLS/C1883719	denotes	rtion cau
T5387	8287-8301	UMLS/C0086282	denotes	ed in heart of
T5388	7172-7179	UMLS/C0557651	denotes	CR prim
T5389	7928-7936	UMLS/C1555707	denotes	-1α−/− m
T5390	6610-6616	UMLS/C0015127	denotes	ed an
T5391	7563-7570	UMLS/C1704444	denotes	−/− mic
T5392	6332-6338	UMLS/C1553877	denotes	elete
T5393	6726-6737	UMLS/C1549081	denotes	ination at
T5394	7381-7388	UMLS/C0150312	denotes	PGC-1α−
T5395	7575-7582	UMLS/C0150312	denotes	gure 1D
T5396	7673-7680	UMLS/C0150312	denotes	n WT an
T5397	6450-6459	UMLS/C1512796	denotes	rtion of
T5398	6511-6520	UMLS/C1512796	denotes	rtion/rec
T5399	6600-6609	UMLS/C1512796	denotes	rtion cau
T5400	7956-7964	UMLS/C0205409	denotes	itions o
T5401	7284-7290	UMLS/C1522411	denotes	cted t
T5402	7357-7363	UMLS/C1522411	denotes	be pr
T5403	7640-7646	UMLS/C1522411	denotes	in bot
T5404	6992-6997	UMLS/C0018787	denotes	and
T5405	7463-7468	UMLS/C0018787	denotes	(WT)
T5406	8353-8358	UMLS/C0018787	denotes	esult
T5407	6287-6292	UMLS/C1549548	denotes	ased
T5408	6237-6247	UMLS/C0332453	denotes	Disruption
T5409	6895-6905	UMLS/C0332453	denotes	ption resu
T5410	8395-8400	UMLS/C1515187	denotes	e tar
T5411	6332-6338	UMLS/C1548566	denotes	elete
T5412	7997-8002	UMLS/C0542339	denotes	cond
T5413	6287-6292	UMLS/C1626935	denotes	ased
T5414	7185-7192	UMLS/C0205435	denotes	re desi
T5415	7870-7882	UMLS/C0442737	denotes	otein extrac
T5416	8166-8178	UMLS/C0442737	denotes	astly, expre
T5417	7956-7964	UMLS/C0370215	denotes	itions o
T5418	6946-6951	UMLS/C0006823	denotes	not
T5419	6766-6778	UMLS/C0242781	denotes	smission of
T5420	7284-7290	UMLS/C1552830	denotes	cted t
T5421	7357-7363	UMLS/C1552830	denotes	be pr
T5422	7640-7646	UMLS/C1552830	denotes	in bot
T5423	6287-6292	UMLS/C1550601	denotes	ased
T5424	7689-7698	UMLS/C1285573	denotes	/− mice,
T5425	6946-6951	UMLS/C0344312	denotes	not
T5426	7185-7192	UMLS/C1279901	denotes	re desi
T5427	6871-6875	UMLS/C1511726	denotes	). T
T5428	7066-7070	UMLS/C1511726	denotes	ntit
T5429	7950-7954	UMLS/C1511726	denotes	l co
T5430	8217-8221	UMLS/C1511726	denotes	nown
T5431	6793-6799	UMLS/C0002085	denotes	le was
T5432	7928-7936	UMLS/C1705851	denotes	-1α−/− m
T5433	8256-8264	UMLS/C0679058	denotes	RC, was
T5434	6766-6778	UMLS/C1521797	denotes	smission of
T5435	8124-8131	UMLS/C0700321	denotes	estern
T5436	7172-7179	UMLS/C1705923	denotes	CR prim
T5437	7760-7770	UMLS/C0205216	denotes	hat the mu
T5438	6484-6493	UMLS/C0012931	denotes	truct (Fi
T5439	6287-6292	UMLS/C1705938	denotes	ased
T5440	7381-7388	UMLS/C0449450	denotes	PGC-1α−
T5441	7575-7582	UMLS/C0449450	denotes	gure 1D
T5442	7673-7680	UMLS/C0449450	denotes	n WT an
T5443	7912-7927	UMLS/C0028589	denotes	from BAT of PG
T5444	6385-6394	UMLS/C1521840	denotes	rgeting e
T5445	6332-6338	UMLS/C1549772	denotes	elete
T5446	6959-6967	UMLS/C0442726	denotes	ted by R
T5447	7451-7459	UMLS/C0442726	denotes	f wild-t
T5448	7704-7712	UMLS/C0442726	denotes	s greatl
T5449	6293-6307	UMLS/C0242613	denotes	ene targeting
T5450	7146-7160	UMLS/C0242613	denotes	ting. For thes
T5451	7258-7268	UMLS/C1549781	denotes	the exon 5
T5452	6716-6725	UMLS/C0205252	denotes	ature ter
T5453	6308-6314	UMLS/C0086022	denotes	ector
T5454	6401-6409	UMLS/C0332294	denotes	sulted i
T5455	6701-6710	UMLS/C0332294	denotes	lting in
T5456	6906-6914	UMLS/C0332294	denotes	ted in a
T5457	8417-8424	UMLS/C0332294	denotes	lted in
T5458	6401-6409	UMLS/C1274040	denotes	sulted i
T5459	6701-6710	UMLS/C1274040	denotes	lting in
T5460	6906-6914	UMLS/C1274040	denotes	ted in a
T5461	8417-8424	UMLS/C1274040	denotes	lted in
T5462	8287-8301	UMLS/C1611821	denotes	ed in heart of
T5463	8083-8089	UMLS/C0205263	denotes	C-1α p
T5464	7258-7268	UMLS/C2700400	denotes	the exon 5
T5465	6385-6394	UMLS/C0599894	denotes	rgeting e
T5466	8124-8131	UMLS/C2700395	denotes	estern
T5467	6450-6459	UMLS/C1705421	denotes	rtion of
T5468	6511-6520	UMLS/C1705421	denotes	rtion/rec
T5469	6600-6609	UMLS/C1705421	denotes	rtion cau
T5470	8026-8042	UMLS/C1154977	denotes	induce the expre
T5471	8038-8051	UMLS/C0231275	denotes	xpression of
T5472	6952-6955	UMLS/C1518422	denotes	e d
T5473	7499-7502	UMLS/C1518422	denotes	1D)
T5474	8324-8327	UMLS/C1518422	denotes	1C
T5475	7892-7896	UMLS/C0007634	denotes	ishe
T5476	8425-8432	UMLS/C0344211	denotes	a PGC-1
T5477	7086-7092	UMLS/C0599161	denotes	utili
T5478	6666-6673	UMLS/C1707531	denotes	tes a c
T5479	7956-7964	UMLS/C1548221	denotes	itions o
T5480	7284-7290	UMLS/C0205284	denotes	cted t
T5481	7357-7363	UMLS/C0205284	denotes	be pr
T5482	7640-7646	UMLS/C0205284	denotes	in bot
T5483	7956-7964	UMLS/C1764827	denotes	itions o
T5484	6401-6409	UMLS/C1546471	denotes	sulted i
T5485	6701-6710	UMLS/C1546471	denotes	lting in
T5486	6906-6914	UMLS/C1546471	denotes	ted in a
T5487	8417-8424	UMLS/C1546471	denotes	lted in
T5488	7258-7268	UMLS/C0332256	denotes	the exon 5
T5489	6420-6444	UMLS/C0599773	denotes	logous recombination wit
T5490	6921-6929	UMLS/C0443343	denotes	ble tran
T5491	7840-7848	UMLS/C0443343	denotes	cell (Fi
T5492	6676-6689	UMLS/C0079941	denotes	ng region fra
T5493	8065-8070	UMLS/C0205309	denotes	Smal
T5494	8275-8280	UMLS/C0205309	denotes	cantl
T5495	6627-6638	UMLS/C1705960	denotes	ication bet
T5496	6450-6459	UMLS/C0441587	denotes	rtion of
T5497	6511-6520	UMLS/C0441587	denotes	rtion/rec
T5498	6600-6609	UMLS/C0441587	denotes	rtion cau
T5499	7389-7393	UMLS/C1720467	denotes	− mi
T5500	7583-7587	UMLS/C1720467	denotes	. An
T7206	10998-11002	UMLS/C1704650	denotes	gene
T7137	13821-13826	UMLS/C1705208	denotes	oleus
T7138	11640-11647	UMLS/C0549177	denotes	− mice
T7139	12112-12119	UMLS/C0549177	denotes	compare
T7140	12288-12292	UMLS/C1292711	denotes	t si
T7141	11722-11730	UMLS/C1882979	denotes	nce was
T7142	13605-13613	UMLS/C1882979	denotes	ights we
T7143	14045-14053	UMLS/C1882979	denotes	ontrast,
T7144	14112-14120	UMLS/C1979874	denotes	ificantl
T7145	11374-11378	UMLS/C0024554	denotes	/− m
T7146	11651-11655	UMLS/C0024554	denotes	ared
T7147	12461-12465	UMLS/C0024554	denotes	ant
T7148	12515-12519	UMLS/C0024554	denotes	than
T7149	13597-13601	UMLS/C0024554	denotes	orga
T7150	13964-13968	UMLS/C0024554	denotes	ed P
T7151	12083-12088	UMLS/C1306645	denotes	wk-ol
T7152	11267-11273	UMLS/C1551394	denotes	ights
T7153	11776-11787	UMLS/C0750502	denotes	24 wk of ag
T7154	12297-12315	UMLS/C0424619	denotes	cantly different b
T7155	10998-11002	UMLS/C0006159	denotes	gene
T7156	12509-12514	UMLS/C0677546	denotes	y fat
T7157	14272-14279	UMLS/C1547928	denotes	nd slow
T7158	12083-12088	UMLS/C1962945	denotes	wk-ol
T7159	13827-13835	UMLS/C0359583	denotes	but not
T7160	14137-14142	UMLS/C0006104	denotes	en th
T7161	11267-11273	UMLS/C1550457	denotes	ights
T7162	11003-11005	UMLS/C0319022	denotes	at
T7163	11419-11421	UMLS/C0319022	denotes	te
T7164	11696-11698	UMLS/C0319022	denotes	e
T7165	12177-12179	UMLS/C0319022	denotes	t
T7166	12294-12296	UMLS/C0319022	denotes	if
T7167	11622-11625	UMLS/C0005341	denotes	nd
T7168	13890-13893	UMLS/C0005341	denotes	ly
T7169	11267-11273	UMLS/C1704701	denotes	ights
T7170	11410-11418	UMLS/C1546849	denotes	1α+/+ li
T7171	11341-11350	UMLS/C0392756	denotes	mass for
T7172	11030-11039	UMLS/C0680063	denotes	e observe
T7173	11077-11086	UMLS/C0680063	denotes	e consist
T7174	11183-11192	UMLS/C0680063	denotes	e not obs
T7175	11248-11257	UMLS/C0680063	denotes	rmal. Tot
T7176	13955-13960	UMLS/C1548802	denotes	sex-m
T7177	14137-14142	UMLS/C0006111	denotes	en th
T7178	13955-13960	UMLS/C1619811	denotes	sex-m
T7179	12083-12088	UMLS/C0034571	denotes	wk-ol
T7180	11281-11293	UMLS/C0944911	denotes	1 wk after
T7181	11473-11479	UMLS/C0944911	denotes	1α−/−
T7182	11597-11608	UMLS/C0944911	denotes	icantly gre
T7183	11749-11755	UMLS/C0944911	denotes	r fema
T7184	12244-12255	UMLS/C0944911	denotes	eased body
T7185	13788-13795	UMLS/C0944911	denotes	es, inc
T7186	14126-14133	UMLS/C0944911	denotes	erent b
T7187	13678-13686	UMLS/C1516048	denotes	ism for
T7188	12563-12567	UMLS/C0205172	denotes	dat
T7189	13955-13960	UMLS/C1708760	denotes	sex-m
T7190	12334-12338	UMLS/C0577559	denotes	s (u
T7191	14163-14166	UMLS/C0006298	denotes	wk
T7192	12329-12333	UMLS/C2709063	denotes	otyp
T7193	14234-14244	UMLS/C2348792	denotes	l energy r
T7194	10952-10959	UMLS/C0028754	denotes	ty Hete
T7195	14163-14166	UMLS/C1412726	denotes	wk
T7196	13955-13960	UMLS/C0441994	denotes	sex-m
T7197	12224-12234	UMLS/C1444656	denotes	ast in par
T7198	13917-13934	UMLS/C1305065	denotes	PGC-1α−/− mice c
T7199	12533-12537	UMLS/C0205136	denotes	ols
T7200	12004-12013	UMLS/C1704646	denotes	s determi
T7201	11473-11479	UMLS/C0043100	denotes	1α−/−
T7202	11749-11755	UMLS/C0043100	denotes	r fema
T7203	13788-13795	UMLS/C0043100	denotes	es, inc
T7204	14126-14133	UMLS/C0043100	denotes	erent b
T7205	12057-12067	UMLS/C0521095	denotes	was greate
T7207	13688-13693	UMLS/C1947971	denotes	stnat
T7208	12083-12088	UMLS/C1714805	denotes	wk-ol
T7209	14083-14085	UMLS/C1706096	denotes	ki
T7210	14253-14255	UMLS/C1706096	denotes	ts
T7211	11992-12000	UMLS/C1561536	denotes	body fa
T7212	11360-11369	UMLS/C0518010	denotes	female PG
T7213	14151-14157	UMLS/C0022646	denotes	es at
T7214	12089-12099	UMLS/C0000854	denotes	female PG
T7215	10938-10941	UMLS/C1879943	denotes	epe
T7216	13821-13826	UMLS/C1260603	denotes	oleus
T7217	11473-11479	UMLS/C1705104	denotes	1α−/−
T7218	11749-11755	UMLS/C1705104	denotes	r fema
T7219	13788-13795	UMLS/C1705104	denotes	es, inc
T7220	14126-14133	UMLS/C1705104	denotes	erent b
T7221	12004-12013	UMLS/C0728873	denotes	s determi
T7222	14285-14289	UMLS/C1561958	denotes	h sk
T7223	14285-14289	UMLS/C1561957	denotes	h sk
T7224	13799-13804	UMLS/C1281570	denotes	ng ga
T7225	14333-14338	UMLS/C1281570	denotes	in P
T7226	11722-11730	UMLS/C0009932	denotes	nce was
T7227	13605-13613	UMLS/C0009932	denotes	ights we
T7228	14045-14053	UMLS/C0009932	denotes	ontrast,
T7229	11374-11378	UMLS/C1706180	denotes	/− m
T7230	11651-11655	UMLS/C1706180	denotes	ared
T7231	12461-12465	UMLS/C1706180	denotes	ant
T7232	12515-12519	UMLS/C1706180	denotes	than
T7233	13597-13601	UMLS/C1706180	denotes	orga
T7234	13964-13968	UMLS/C1706180	denotes	ed P
T7235	12004-12013	UMLS/C1516647	denotes	s determi
T7236	11308-11313	UMLS/C0687676	denotes	a 15%
T7237	14272-14279	UMLS/C0040300	denotes	nd slow
T7238	12288-12292	UMLS/C1148523	denotes	t si
T7239	12101-12105	UMLS/C1510486	denotes	1α−/
T7240	12422-12426	UMLS/C1510486	denotes	e at
T7241	12334-12338	UMLS/C1546709	denotes	s (u
T7242	11092-11107	UMLS/C1524057	denotes	th the expected
T7243	12004-12013	UMLS/C0181904	denotes	s determi
T7244	12288-12292	UMLS/C1552020	denotes	t si
T7245	11294-11302	UMLS/C1301820	denotes	irth rev
T7246	13821-13826	UMLS/C0225326	denotes	oleus
T7247	11374-11378	UMLS/C0325595	denotes	/− m
T7248	11651-11655	UMLS/C0325595	denotes	ared
T7249	12461-12465	UMLS/C0325595	denotes	ant
T7250	12515-12519	UMLS/C0325595	denotes	than
T7251	13597-13601	UMLS/C0325595	denotes	orga
T7252	13964-13968	UMLS/C0325595	denotes	ed P
T7253	11281-11293	UMLS/C0005910	denotes	1 wk after
T7254	11597-11608	UMLS/C0005910	denotes	icantly gre
T7255	12244-12255	UMLS/C0005910	denotes	eased body
T7256	10929-10933	UMLS/C0001792	denotes	and
T7257	11563-11566	UMLS/C0001792	denotes	ody
T7258	11592-11595	UMLS/C0001792	denotes	ign
T7259	11831-11834	UMLS/C0001792	denotes	GC-
T7260	12504-12507	UMLS/C0001792	denotes	e b
T7261	12546-12549	UMLS/C0001792	denotes	A a
T7262	14014-14017	UMLS/C0001792	denotes	2B
T7263	14071-14074	UMLS/C0001792	denotes	ain
T7264	13821-13826	UMLS/C1556142	denotes	oleus
T7265	12520-12526	UMLS/C0596988	denotes	male W
T7266	13882-13888	UMLS/C1305356	denotes	nifica
T7267	12089-12099	UMLS/C0220777	denotes	female PG
T7268	10929-10933	UMLS/C0001779	denotes	and
T7269	11563-11566	UMLS/C0001779	denotes	ody
T7270	11592-11595	UMLS/C0001779	denotes	ign
T7271	11831-11834	UMLS/C0001779	denotes	GC-
T7272	12504-12507	UMLS/C0001779	denotes	e b
T7273	12546-12549	UMLS/C0001779	denotes	A a
T7274	14014-14017	UMLS/C0001779	denotes	2B
T7275	14071-14074	UMLS/C0001779	denotes	ain
T7276	11374-11378	UMLS/C0086582	denotes	/− m
T7277	11651-11655	UMLS/C0086582	denotes	ared
T7278	12461-12465	UMLS/C0086582	denotes	ant
T7279	12515-12519	UMLS/C0086582	denotes	than
T7280	13597-13601	UMLS/C0086582	denotes	orga
T7281	13964-13968	UMLS/C0086582	denotes	ed P
T7282	12004-12013	UMLS/C0596972	denotes	s determi
T7283	14144-14149	UMLS/C0023884	denotes	genot
T7284	13955-13960	UMLS/C1550472	denotes	sex-m
T7285	13821-13826	UMLS/C1304649	denotes	oleus
T7286	13648-13658	UMLS/C1550471	denotes	f mitochon
T7287	10929-10933	UMLS/C0001811	denotes	and
T7288	11563-11566	UMLS/C0001811	denotes	ody
T7289	11592-11595	UMLS/C0001811	denotes	ign
T7290	11831-11834	UMLS/C0001811	denotes	GC-
T7291	12504-12507	UMLS/C0001811	denotes	e b
T7292	12546-12549	UMLS/C0001811	denotes	A a
T7293	14014-14017	UMLS/C0001811	denotes	2B
T7294	14071-14074	UMLS/C0001811	denotes	ain
T7295	11294-11302	UMLS/C1706701	denotes	irth rev
T7296	11281-11293	UMLS/C1305866	denotes	1 wk after
T7297	11597-11608	UMLS/C1305866	denotes	icantly gre
T7298	12244-12255	UMLS/C1305866	denotes	eased body
T7299	11063-11069	UMLS/C1610540	denotes	offsp
T7300	11131-11137	UMLS/C1610540	denotes	lished
T7301	14144-14149	UMLS/C0023895	denotes	genot
T7302	12083-12088	UMLS/C0043299	denotes	wk-ol
T7303	11054-11062	UMLS/C0017431	denotes	os of th
T7304	12383-12392	UMLS/C0017431	denotes	t excess
T7305	14212-14221	UMLS/C0017431	denotes	with high
T7306	11275-11285	UMLS/C0229960	denotes	tained 1 w
T7307	11354-11364	UMLS/C0229960	denotes	e and fema
T7308	12083-12088	UMLS/C0043309	denotes	wk-ol
T7309	10938-10941	UMLS/C0036864	denotes	epe
T7310	14304-14323	UMLS/C0489460	denotes	exhibit modest grow
T7311	13726-13743	UMLS/C0014272	denotes	weights of heart
T7312	12288-12292	UMLS/C0449719	denotes	t si
T7313	11852-11872	UMLS/C0332544	denotes	associated with dif
T7314	12442-12448	UMLS/C1979886	denotes	age, o
T7315	13836-13852	UMLS/C1546780	denotes	the less oxidati
T7316	13864-13877	UMLS/C1305344	denotes	anterior, wer
T7317	11935-11946	UMLS/C0013470	denotes	neral activ
T7318	13917-13934	UMLS/C0242690	denotes	PGC-1α−/− mice c
T7319	11756-11766	UMLS/C1705241	denotes	e PGC-1α−/
T7320	11920-11931	UMLS/C1705241	denotes	terations i
T7321	12256-12266	UMLS/C1705241	denotes	at (Figure
T7322	13836-13852	UMLS/C0242692	denotes	the less oxidati
T7323	13864-13877	UMLS/C0242691	denotes	anterior, wer
T7324	11722-11730	UMLS/C1550141	denotes	nce was
T7325	13605-13613	UMLS/C1550141	denotes	ights we
T7326	14045-14053	UMLS/C1550141	denotes	ontrast,
T7327	11756-11766	UMLS/C1705242	denotes	e PGC-1α−/
T7328	11920-11931	UMLS/C1705242	denotes	terations i
T7329	12256-12266	UMLS/C1705242	denotes	at (Figure
T7330	12361-12370	UMLS/C1705242	denotes	ugh DEXA
T7331	14190-14199	UMLS/C1705242	denotes	Thus, cer
T7332	11687-11695	UMLS/C1707455	denotes	ls (Figu
T7333	12168-12176	UMLS/C1707455	denotes	ndicatin
T7334	14000-14008	UMLS/C1707455	denotes	of age (
T7335	11410-11418	UMLS/C0205345	denotes	1α+/+ li
T7336	11383-11389	UMLS/C0086287	denotes	elativ
T7337	11660-11666	UMLS/C0086287	denotes	ex-mat
T7338	11792-11798	UMLS/C0086287	denotes	gure 2
T7339	12141-12147	UMLS/C0086287	denotes	e PGC-
T7340	12192-12198	UMLS/C0086287	denotes	weight
T7341	13973-13979	UMLS/C0086287	denotes	+/+ co
T7342	13882-13888	UMLS/C0242694	denotes	nifica
T7343	10877-10884	UMLS/C1553889	denotes	General
T7344	11984-11991	UMLS/C1553889	denotes	Percen
T7345	13688-13693	UMLS/C1550718	denotes	stnat
T7346	10929-10933	UMLS/C1114365	denotes	and
T7347	11563-11566	UMLS/C1114365	denotes	ody
T7348	11592-11595	UMLS/C1114365	denotes	ign
T7349	11831-11834	UMLS/C1114365	denotes	GC-
T7350	12504-12507	UMLS/C1114365	denotes	e b
T7351	12546-12549	UMLS/C1114365	denotes	A a
T7352	14014-14017	UMLS/C1114365	denotes	2B
T7353	14071-14074	UMLS/C1114365	denotes	ain
T7354	11158-11175	UMLS/C0277591	denotes	aths of the offsp
T7355	12334-12338	UMLS/C1306372	denotes	s (u
T7356	10885-10900	UMLS/C1521970	denotes	Characteristics
T7357	12031-12033	UMLS/C1179704	denotes	X
T7358	13776-13782	UMLS/C0029235	denotes	eletal
T7359	11640-11647	UMLS/C0205393	denotes	− mice
T7360	12112-12119	UMLS/C0205393	denotes	compare
T7361	11383-11389	UMLS/C0015780	denotes	elativ
T7362	11660-11666	UMLS/C0015780	denotes	ex-mat
T7363	11792-11798	UMLS/C0015780	denotes	gure 2
T7364	12141-12147	UMLS/C0015780	denotes	e PGC-
T7365	12192-12198	UMLS/C0015780	denotes	weight
T7366	13973-13979	UMLS/C0015780	denotes	+/+ co
T7367	10938-10941	UMLS/C1522384	denotes	epe
T7368	13688-13693	UMLS/C1442162	denotes	stnat
T7369	13659-13672	UMLS/C0029218	denotes	rial energy m
T7370	12563-12567	UMLS/C0439064	denotes	dat
T7371	13836-13852	UMLS/C1550659	denotes	the less oxidati
T7372	14137-14142	UMLS/C1269537	denotes	en th
T7373	11992-12000	UMLS/C0441655	denotes	body fa
T7374	11267-11273	UMLS/C1873497	denotes	ights
T7375	13712-13725	UMLS/C0026237	denotes	n organs. The
T7376	14290-14303	UMLS/C0026237	denotes	letal muscle,
T7377	13799-13804	UMLS/C0018787	denotes	ng ga
T7378	14333-14338	UMLS/C0018787	denotes	in P
T7379	14285-14289	UMLS/C1522410	denotes	h sk
T7380	13768-13775	UMLS/C0205423	denotes	iched s
T7381	14264-14271	UMLS/C0205423	denotes	heart
T7382	12031-12033	UMLS/C1835435	denotes	X
T7383	11722-11730	UMLS/C1547100	denotes	nce was
T7384	13605-13613	UMLS/C1547100	denotes	ights we
T7385	14045-14053	UMLS/C1547100	denotes	ontrast,
T7386	11045-11053	UMLS/C1441672	denotes	type rat
T7387	11202-11210	UMLS/C1441672	denotes	PGC-1α+
T7388	13854-13863	UMLS/C1552866	denotes	tibialis
T7389	10942-10951	UMLS/C1701901	denotes	dent Obes
T7390	12431-12441	UMLS/C0442737	denotes	r 24 wk of
T7391	10952-10959	UMLS/C1963185	denotes	ty Hete
T7392	13712-13725	UMLS/C0521451	denotes	n organs. The
T7393	14290-14303	UMLS/C0521451	denotes	letal muscle,
T7394	11054-11062	UMLS/C1285573	denotes	os of th
T7395	12383-12392	UMLS/C1285573	denotes	t excess
T7396	14212-14221	UMLS/C1285573	denotes	with high
T7397	10960-10972	UMLS/C0019425	denotes	ozygous (PGC
T7398	12004-12013	UMLS/C0150369	denotes	s determi
T7399	13776-13782	UMLS/C0178784	denotes	eletal
T7400	13821-13826	UMLS/C0012173	denotes	oleus
T7401	12044-12052	UMLS/C0344335	denotes	tion (DE
T7402	12449-12457	UMLS/C0344335	denotes	der male
T7403	12568-13591	UMLS/C0344335	denotes	). Figure 2 Evidence for Tissue-Specific Growth Abnormalities and Mild Sex-Limited, Age-Dependent Obesity in PGC-1α−/− Mice (A) The bars represent total body weight for the ages indicated for male (left graph) and female (center graph) PGC-1α+/+ and PGC-1α−/− mice. The body weight (BW) of the 1-wk-old PGC-1α−/− mice was normalized to that of PGC-1α+/+ littermates, which was assigned a value of 100 (left axis). For the 3-, 18-, and 24-wk time points, absolute weights of PGC-1α−/− mice were compared to age-matched controls (right axis). Percent fat as determined by DEXA scanning for PGC-1α+/+ and PGC-1α−/− mice (right graph). The results represent n = 4 (males) and n ≥ 11 (females) for each genotype at 24 wk. * p < 0.05 compared to corresponding PGC-1α+/+ mice. (B) The bars represent organ weights corrected to body weight for 3-wk-old male and female PGC-1α+/+ and PGC-1α−/− mice. The error bars represent ± SEM. Results represent n ≥ 14 for each group. * p < 0.05 compared to corresponding PGC-1α+/+ mice. Indiv
T7404	11151-11155	UMLS/C1511726	denotes	cted
T7405	11960-11964	UMLS/C1511726	denotes	ed f
T7406	12406-12410	UMLS/C1511726	denotes	le P
T7407	13641-13645	UMLS/C1511726	denotes	tanc
T7408	14102-14106	UMLS/C1511726	denotes	e no
T7409	11722-11730	UMLS/C0243148	denotes	nce was
T7410	13605-13613	UMLS/C0243148	denotes	ights we
T7411	14045-14053	UMLS/C0243148	denotes	ontrast,
T7412	12540-12542	UMLS/C0026402	denotes	gu
T7413	11992-12000	UMLS/C0439167	denotes	body fa
T7414	11267-11273	UMLS/C0439166	denotes	ights
T7415	12036-12043	UMLS/C0439165	denotes	y absor
T7416	11410-11418	UMLS/C1547039	denotes	1α+/+ li
T7417	14151-14157	UMLS/C1278978	denotes	es at
T7418	13907-13916	UMLS/C0311404	denotes	and femal
T7419	11063-11069	UMLS/C1547037	denotes	offsp
T7420	11131-11137	UMLS/C1547037	denotes	lished
T7421	11341-11350	UMLS/C0301630	denotes	mass for
T7422	12509-12514	UMLS/C0580836	denotes	y fat
T7423	11640-11647	UMLS/C1704243	denotes	− mice
T7424	12112-12119	UMLS/C1704243	denotes	compare
T7425	12089-12099	UMLS/C2347080	denotes	female PG
T7426	10998-11002	UMLS/C1548147	denotes	gene
T7427	13821-13826	UMLS/C0304068	denotes	oleus
T7428	13748-13764	UMLS/C0243109	denotes	low-twitch fiber
T7429	11267-11273	UMLS/C2347086	denotes	ights
T7430	11320-11328	UMLS/C0443289	denotes	duction
T7431	10942-10951	UMLS/C0851827	denotes	dent Obes
T7432	13955-13960	UMLS/C0234886	denotes	sex-m
T7433	13955-13960	UMLS/C0205251	denotes	sex-m
T7434	11410-11418	UMLS/C0080103	denotes	1α+/+ li
T7435	11969-11980	UMLS/C1515926	denotes	h (Figure
T7436	14285-14289	UMLS/C0205250	denotes	h sk
T7437	13955-13960	UMLS/C1611820	denotes	sex-m
T7438	11092-11107	UMLS/C0332290	denotes	th the expected
T7439	10877-10884	UMLS/C0205246	denotes	General
T7440	11984-11991	UMLS/C0205246	denotes	Percen
T7441	12031-12033	UMLS/C1419027	denotes	X
T7442	13854-13863	UMLS/C2700399	denotes	tibialis
T7443	11722-11730	UMLS/C0332298	denotes	nce was
T7444	13605-13613	UMLS/C0332298	denotes	ights we
T7445	14045-14053	UMLS/C0332298	denotes	ontrast,
T7446	12540-12542	UMLS/C0439231	denotes	gu
T7447	11305-11307	UMLS/C0439230	denotes	ed
T7448	11557-11559	UMLS/C0439230	denotes	ag
T7449	11586-11588	UMLS/C0439230	denotes	b
T7450	11825-11827	UMLS/C0439230	denotes	n
T7451	12498-12500	UMLS/C0439230	denotes	ed
T7452	14065-14067	UMLS/C0439230	denotes	o
T7453	13768-13775	UMLS/C1704787	denotes	iched s
T7454	14264-14271	UMLS/C1704787	denotes	heart
T7455	11063-11069	UMLS/C0456603	denotes	offsp
T7456	11131-11137	UMLS/C0456603	denotes	lished
T7457	11198-11201	UMLS/C1518422	denotes	an
T7458	11900-11903	UMLS/C1518422	denotes	ubl
T7459	12343-12346	UMLS/C1518422	denotes	ish
T7460	13894-13897	UMLS/C1518422	denotes	owe
T7461	14172-14175	UMLS/C1518422	denotes	oin
T7462	11904-11919	UMLS/C0332281	denotes	shed data) or a
T7463	11314-11319	UMLS/C0005615	denotes	20% r
T7464	11112-11120	UMLS/C0679138	denotes	elian ra
T7465	12004-12013	UMLS/C1521743	denotes	s determi
T7466	11374-11378	UMLS/C1706429	denotes	/− m
T7467	11651-11655	UMLS/C1706429	denotes	ared
T7468	12461-12465	UMLS/C1706429	denotes	ant
T7469	12515-12519	UMLS/C1706429	denotes	than
T7470	13597-13601	UMLS/C1706429	denotes	orga
T7471	13964-13968	UMLS/C1706429	denotes	ed P
T7472	11374-11378	UMLS/C1706428	denotes	/− m
T7473	11651-11655	UMLS/C1706428	denotes	ared
T7474	12461-12465	UMLS/C1706428	denotes	ant
T7475	12515-12519	UMLS/C1706428	denotes	than
T7476	13597-13601	UMLS/C1706428	denotes	orga
T7477	13964-13968	UMLS/C1706428	denotes	ed P
T7478	13854-13863	UMLS/C0332257	denotes	tibialis
T7479	11112-11120	UMLS/C1517001	denotes	elian ra
T7480	13836-13852	UMLS/C1280260	denotes	the less oxidati
T7481	11308-11313	UMLS/C0231290	denotes	a 15%
T7482	11341-11350	UMLS/C0441610	denotes	mass for
T7483	11575-11577	UMLS/C1706446	denotes	as
T7484	11739-11741	UMLS/C1706446	denotes	if
T7485	11843-11845	UMLS/C1706446	denotes	e
T7486	12324-12326	UMLS/C1706446	denotes	e
T7487	13622-13624	UMLS/C1706446	denotes	ed
T7488	11314-11319	UMLS/C1550722	denotes	20% r
T7489	10938-10941	UMLS/C1314687	denotes	epe
T7490	11267-11273	UMLS/C0205307	denotes	ights
T7491	11776-11787	UMLS/C1546944	denotes	24 wk of ag
T7492	12031-12033	UMLS/C0879262	denotes	X
T7493	14285-14289	UMLS/C1299351	denotes	h sk
T7494	13955-13960	UMLS/C1299352	denotes	sex-m
T7495	11383-11389	UMLS/C1705497	denotes	elativ
T7496	11660-11666	UMLS/C1705497	denotes	ex-mat
T7497	11792-11798	UMLS/C1705497	denotes	gure 2
T7498	12141-12147	UMLS/C1705497	denotes	e PGC-
T7499	12192-12198	UMLS/C1705497	denotes	weight
T7500	13973-13979	UMLS/C1705497	denotes	+/+ co
T7501	12334-12338	UMLS/C0026385	denotes	s (u
T7502	11383-11389	UMLS/C1705498	denotes	elativ
T7503	11660-11666	UMLS/C1705498	denotes	ex-mat
T7504	11792-11798	UMLS/C1705498	denotes	gure 2
T7505	12141-12147	UMLS/C1705498	denotes	e PGC-
T7506	12192-12198	UMLS/C1705498	denotes	weight
T7507	13973-13979	UMLS/C1705498	denotes	+/+ co
T7508	11722-11730	UMLS/C2587213	denotes	nce was
T7509	13605-13613	UMLS/C2587213	denotes	ights we
T7510	14045-14053	UMLS/C2587213	denotes	ontrast,
T7511	11744-11748	UMLS/C0323983	denotes	nt f
T7512	14144-14149	UMLS/C1278929	denotes	genot
T9143	17594-17601	UMLS/C0221099	denotes	e, mito
T9144	18107-18114	UMLS/C0221099	denotes	ith the
T9145	15842-15851	UMLS/C0035647	denotes	drial bio
T9146	15742-15771	UMLS/C1326316	denotes	iption, was diminished in PGC
T9147	15069-15080	UMLS/C0200760	denotes	ron microgr
T9148	15034-15042	UMLS/C1882979	denotes	antitati
T9149	15245-15253	UMLS/C1882979	denotes	s in the
T9150	15660-15668	UMLS/C1882979	denotes	n of Tfa
T9151	15917-15925	UMLS/C1979874	denotes	gnifican
T9152	17992-17999	UMLS/C2348205	denotes	ng of r
T9153	14485-14489	UMLS/C1563320	denotes	grow
T9154	17857-17862	UMLS/C0205112	denotes	gure
T9155	15494-15506	UP/P68099	denotes	idase IV) an
T9156	15957-15968	UMLS/C0750502	denotes	ltrastructu
T9157	17780-17791	UMLS/C0750502	denotes	n, but not
T9158	14384-14393	UMLS/C1314763	denotes	Phenotype
T9159	15297-15306	UMLS/C0729650	denotes	ent with
T9160	15494-15506	UP/P00144	denotes	idase IV) an
T9161	15494-15506	UP/P00048	denotes	idase IV) an
T9162	17811-17814	UMLS/C0001459	denotes	de
T9163	15109-15118	UMLS/C0750484	denotes	lar volum
T9164	15254-15265	UMLS/C0085862	denotes	myofibrilla
T9165	15494-15506	UP/P00072	denotes	idase IV) an
T9166	17802-17807	UMLS/C1442792	denotes	sal),
T9167	17924-17929	UMLS/C1442792	denotes	were
T9168	14671-14678	UMLS/C1547928	denotes	1–2-mo
T9169	14870-14877	UMLS/C1547928	denotes	microsc
T9170	17701-17707	UMLS/C1547928	denotes	of PG
T9171	18070-18073	UMLS/C0001480	denotes	mi
T9172	15494-15506	UP/P00047	denotes	idase IV) an
T9173	15494-15506	UP/P00071	denotes	idase IV) an
T9174	15494-15506	UP/P99998	denotes	idase IV) an
T9175	15494-15506	UP/P00035	denotes	idase IV) an
T9176	15494-15506	UP/P15451	denotes	idase IV) an
T9177	14354-14362	UMLS/C1550458	denotes	Abnormal
T9178	15494-15506	UP/Q4UEA0	denotes	idase IV) an
T9179	15494-15506	UP/P00147	denotes	idase IV) an
T9180	15056-15068	UMLS/C0392762	denotes	of the elec
T9181	15297-15306	UMLS/C1179435	denotes	ent with
T9182	15828-15837	UMLS/C0359589	denotes	ctive mit
T9183	14816-14824	UMLS/C0332128	denotes	rial ult
T9184	15494-15506	UP/P00027	denotes	idase IV) an
T9185	18070-18073	UMLS/C1705556	denotes	mi
T9186	17686-17694	UMLS/C0444706	denotes	scle. In
T9187	14839-14853	UMLS/C0041623	denotes	the relevant t
T9188	15998-16012	UMLS/C0041623	denotes	d in heart or
T9189	14490-14496	UMLS/C0018270	denotes	h defe
T9190	14460-14462	UMLS/C0319022	denotes	gi
T9191	14469-14471	UMLS/C0319022	denotes	al
T9192	14998-15000	UMLS/C0319022	denotes	d
T9193	15231-15233	UMLS/C0319022	denotes	de
T9194	15926-15928	UMLS/C0319022	denotes	d
T9195	17546-17548	UMLS/C0319022	denotes	a
T9196	18067-18069	UMLS/C0319022	denotes	−/
T9197	17840-17843	UMLS/C0005341	denotes	the
T9198	15494-15506	UP/P67881	denotes	idase IV) an
T9199	15494-15506	UP/P00069	denotes	idase IV) an
T9200	15494-15506	UP/Q6IQM2	denotes	idase IV) an
T9201	15494-15506	UP/P38091	denotes	idase IV) an
T9202	15494-15506	UP/P68098	denotes	idase IV) an
T9203	15494-15506	UP/Q52V08	denotes	idase IV) an
T9204	15494-15506	UP/P00040	denotes	idase IV) an
T9205	15494-15506	UP/P00057	denotes	idase IV) an
T9206	15494-15506	UP/P00143	denotes	idase IV) an
T9207	15385-15394	UMLS/C0392756	denotes	nuclear
T9208	15460-15492	UMLS/C1752477	denotes	rt (cytochrome c and cytochrome
T9209	15494-15506	UP/P00029	denotes	idase IV) an
T9210	15193-15198	UMLS/C1548802	denotes	compa
T9211	15269-15276	UMLS/C0392747	denotes	mponent
T9212	15494-15506	UP/P00020	denotes	idase IV) an
T9213	15137-15143	UMLS/C2700258	denotes	mitoc
T9214	16016-16022	UMLS/C2700258	denotes	of PGC
T9215	15297-15306	UMLS/C1548799	denotes	ent with
T9216	15494-15506	UP/P18822	denotes	idase IV) an
T9217	15193-15198	UMLS/C1619811	denotes	compa
T9218	15494-15506	UP/P29380	denotes	idase IV) an
T9219	15494-15506	UP/P62895	denotes	idase IV) an
T9220	15494-15506	UP/O07091	denotes	idase IV) an
T9221	15494-15506	UP/P00066	denotes	idase IV) an
T9222	15494-15506	UP/O22642	denotes	idase IV) an
T9223	15494-15506	UMLS/C0653778	denotes	idase IV) an
T9224	15494-15506	UP/Q41346	denotes	idase IV) an
T9225	15494-15506	UP/P00061	denotes	idase IV) an
T9226	15494-15506	UP/P00148	denotes	idase IV) an
T9227	15494-15506	UMLS/C0010754	denotes	idase IV) an
T9228	15494-15506	UP/P62772	denotes	idase IV) an
T9229	15494-15506	UMLS/C0010749	denotes	idase IV) an
T9230	15494-15506	UP/P00142	denotes	idase IV) an
T9231	15494-15506	UP/P53698	denotes	idase IV) an
T9232	14463-14468	UMLS/C1561554	denotes	to e
T9233	14643-14663	UMLS/C0015350	denotes	lar matrix in the ti
T9234	15494-15506	UP/P00076	denotes	idase IV) an
T9235	15494-15506	UP/P68096	denotes	idase IV) an
T9236	15494-15506	UP/P00003	denotes	idase IV) an
T9237	15494-15506	UP/A8WQY3	denotes	idase IV) an
T9238	15494-15506	UP/P00012	denotes	idase IV) an
T9239	15494-15506	UP/P67882	denotes	idase IV) an
T9240	15494-15506	UP/P00075	denotes	idase IV) an
T9241	15193-15198	UMLS/C1708760	denotes	compa
T9242	15494-15506	UP/P00056	denotes	idase IV) an
T9243	15494-15506	UP/P00149	denotes	idase IV) an
T9244	15494-15506	UP/P62896	denotes	idase IV) an
T9245	14900-14908	UMLS/C1524024	denotes	fewer an
T9246	15448-15456	UMLS/C1947935	denotes	tron tra
T9247	15730-15738	UMLS/C1947935	denotes	tion/tra
T9248	15494-15506	UP/P00046	denotes	idase IV) an
T9249	17884-17893	UMLS/C0038617	denotes	on rates
T9250	14354-14362	UMLS/C0205161	denotes	Abnormal
T9251	17499-17502	UMLS/C0006298	denotes	To
T9252	15109-15118	UMLS/C1456348	denotes	lar volum
T9253	17499-17502	UMLS/C1412726	denotes	To
T9254	15193-15198	UMLS/C0441994	denotes	compa
T9255	15439-15447	UMLS/C0033684	denotes	rial ele
T9256	18023-18033	UMLS/C1444656	denotes	tion was n
T9257	17844-17853	UMLS/C1706613	denotes	substrate
T9258	16036-16041	UMLS/C1317574	denotes	npubl
T9259	15494-15506	UP/P00052	denotes	idase IV) an
T9260	15494-15506	UP/P00070	denotes	idase IV) an
T9261	15494-15506	UP/P81459	denotes	idase IV) an
T9262	17663-17680	UMLS/C0231832	denotes	prepared from sol
T9263	17932-17949	UMLS/C0231832	denotes	so similar betwee
T9264	15772-15785	UMLS/C0040649	denotes	1α−/− soleus,
T9265	15494-15506	UP/P00078	denotes	idase IV) an
T9266	15511-15529	UMLS/C0010760	denotes	dative phosphoryla
T9267	15109-15118	UMLS/C0521093	denotes	lar volum
T9268	17549-17558	UMLS/C0521095	denotes	tered in
T9269	14450-14459	UMLS/C1550369	denotes	rmed to b
T9270	14735-14740	UMLS/C1947971	denotes	nt ro
T9271	15402-15412	UMLS/C0017262	denotes	coding pro
T9272	15687-15697	UMLS/C0017262	denotes	arget invo
T9273	15315-15317	UMLS/C1706097	denotes	in
T9274	14497-14503	UMLS/C0243067	denotes	t foun
T9275	15338-15344	UMLS/C0243067	denotes	esis,
T9276	17792-17798	UMLS/C0243067	denotes	tate 2
T9277	15448-15456	UMLS/C1314939	denotes	tron tra
T9278	15730-15738	UMLS/C1314939	denotes	tion/tra
T9279	15254-15265	UMLS/C1299583	denotes	myofibrilla
T9280	15494-15506	UP/Q7YR71	denotes	idase IV) an
T9281	15001-15005	UMLS/C1879943	denotes	GC-1
T9282	15494-15506	UP/P00077	denotes	idase IV) an
T9283	15494-15506	UP/P00032	denotes	idase IV) an
T9284	14363-14369	UMLS/C1995013	denotes	Muscle
T9285	15494-15506	UP/Q6Q4H8	denotes	idase IV) an
T9286	17708-17714	UMLS/C1321564	denotes	-1α−/−
T9287	17958-17966	UMLS/C0392148	denotes	otypes,
T9288	15137-15143	UMLS/C1705102	denotes	mitoc
T9289	16016-16022	UMLS/C1705102	denotes	of PGC
T9290	14450-14459	UMLS/C0884358	denotes	rmed to b
T9291	17708-17714	UMLS/C0185047	denotes	-1α−/−
T9292	15494-15506	UP/Q52V10	denotes	idase IV) an
T9293	14485-14489	UMLS/C0547040	denotes	grow
T9294	15494-15506	UP/P00017	denotes	idase IV) an
T9295	15494-15506	UP/P00151	denotes	idase IV) an
T9296	15034-15042	UMLS/C0009932	denotes	antitati
T9297	15245-15253	UMLS/C0009932	denotes	s in the
T9298	15660-15668	UMLS/C0009932	denotes	n of Tfa
T9299	14928-14935	UMLS/C0547044	denotes	ia in s
T9300	14523-14528	UMLS/C1281570	denotes	and
T9301	16045-16050	UMLS/C1281570	denotes	d dat
T9302	15494-15506	UP/P19681	denotes	idase IV) an
T9303	15494-15506	UP/P62894	denotes	idase IV) an
T9304	15494-15506	UP/P00036	denotes	idase IV) an
T9305	18043-18051	UMLS/C1948027	denotes	cantly a
T9306	15494-15506	UP/P00018	denotes	idase IV) an
T9307	15494-15506	UP/P00031	denotes	idase IV) an
T9308	15494-15506	UP/Q4SG99	denotes	idase IV) an
T9309	15494-15506	UP/P00062	denotes	idase IV) an
T9310	17884-17893	UMLS/C0220918	denotes	on rates
T9311	17815-17825	UMLS/C1948023	denotes	ected usin
T9312	15494-15506	UP/P00138	denotes	idase IV) an
T9313	15494-15506	UP/Q753F4	denotes	idase IV) an
T9314	15494-15506	UP/P00053	denotes	idase IV) an
T9315	15297-15306	UMLS/C1524073	denotes	ent with
T9316	15494-15506	UP/B4USV4	denotes	idase IV) an
T9317	14671-14678	UMLS/C0040300	denotes	1–2-mo
T9318	14870-14877	UMLS/C0040300	denotes	microsc
T9319	17701-17707	UMLS/C0040300	denotes	of PG
T9320	15494-15506	UP/Q6WUX8	denotes	idase IV) an
T9321	17708-17714	UMLS/C1555557	denotes	-1α−/−
T9322	15128-15136	UMLS/C0178539	denotes	of soleu
T9323	15320-15335	UMLS/C1524057	denotes	tochondrial bio
T9324	18157-18172	UMLS/C1524057	denotes	ondrial volume
T9325	17686-17694	UMLS/C0242485	denotes	scle. In
T9326	15010-15014	UMLS/C0001792	denotes	cont
T9327	17970-17980	UMLS/C0028951	denotes	cating tha
T9328	14485-14489	UMLS/C1547225	denotes	grow
T9329	14490-14496	UMLS/C1457898	denotes	h defe
T9330	15933-15940	UMLS/C1280519	denotes	ences i
T9331	18145-18152	UMLS/C1280519	denotes	on in m
T9332	14599-14612	UMLS/C0000768	denotes	ies in cellul
T9333	17901-17910	UMLS/C1710236	denotes	presence
T9334	14599-14612	UMLS/C0000769	denotes	ies in cellul
T9335	15155-15161	UMLS/C1305356	denotes	signif
T9336	15820-15826	UMLS/C1305356	denotes	for de
T9337	15946-15952	UMLS/C1305356	denotes	chondr
T9338	17747-17753	UMLS/C1305356	denotes	ate 3
T9339	17869-17877	UMLS/C1511790	denotes	ate 4 re
T9340	15430-15438	UMLS/C1547699	denotes	mitochon
T9341	15010-15014	UMLS/C0001779	denotes	cont
T9342	14801-14811	UMLS/C0220781	denotes	mined mito
T9343	15362-15372	UMLS/C0220781	denotes	on in the
T9344	15890-15900	UMLS/C0220781	denotes	results w
T9345	17827-17838	UMLS/C1160636	denotes	succinate a
T9346	18055-18066	UMLS/C1160636	denotes	ed in PGC-1
T9347	15144-15151	UMLS/C0178587	denotes	ondria
T9348	16023-16030	UMLS/C0178587	denotes	1α−/− m
T9349	15193-15198	UMLS/C1550472	denotes	compa
T9350	15581-15593	UMLS/C1622485	denotes	of PGC-1α−/
T9351	15010-15014	UMLS/C0001811	denotes	cont
T9352	15402-15412	UMLS/C0185117	denotes	coding pro
T9353	15687-15697	UMLS/C0185117	denotes	arget invo
T9354	15494-15506	UP/P59218	denotes	idase IV) an
T9355	18012-18021	UMLS/C0017431	denotes	ATP prod
T9356	15494-15506	UP/P00028	denotes	idase IV) an
T9357	14472-14480	UMLS/C0220825	denotes	ate the
T9358	14497-14503	UMLS/C1457869	denotes	t foun
T9359	15338-15344	UMLS/C1457869	denotes	esis,
T9360	17792-17798	UMLS/C1457869	denotes	tate 2
T9361	15494-15506	UP/P00054	denotes	idase IV) an
T9362	14384-14393	UMLS/C0031437	denotes	Phenotype
T9363	15494-15506	UP/P00039	denotes	idase IV) an
T9364	15494-15506	UP/P00043	denotes	idase IV) an
T9365	15494-15506	UP/P68097	denotes	idase IV) an
T9366	14497-14503	UMLS/C0231172	denotes	t foun
T9367	15338-15344	UMLS/C0231172	denotes	esis,
T9368	17792-17798	UMLS/C0231172	denotes	tate 2
T9369	15430-15438	UMLS/C2700640	denotes	mitochon
T9370	15494-15506	UP/P00038	denotes	idase IV) an
T9371	15001-15005	UMLS/C0036864	denotes	GC-1
T9372	17811-17814	UMLS/C1428806	denotes	de
T9373	17686-17694	UMLS/C1879489	denotes	scle. In
T9374	15109-15118	UMLS/C1446409	denotes	lar volum
T9375	17919-17921	UMLS/C1442459	denotes	yc
T9376	14755-14759	UMLS/C0035820	denotes	mit
T9377	17919-17921	UMLS/C0450363	denotes	yc
T9378	14533-14548	UMLS/C1546780	denotes	tal muscle of t
T9379	17609-17624	UMLS/C1546780	denotes	l respiration r
T9380	14900-14908	UMLS/C0002778	denotes	fewer an
T9381	14363-14369	UMLS/C0026845	denotes	Muscle
T9382	15538-15563	UMLS/C0030013	denotes	a subunit of ATP synthase
T9383	15494-15506	UP/P22342	denotes	idase IV) an
T9384	15269-15276	UMLS/C1705241	denotes	mponent
T9385	15969-15980	UMLS/C1705241	denotes	e or volume
T9386	15494-15506	UP/P00073	denotes	idase IV) an
T9387	14533-14548	UMLS/C0242692	denotes	tal muscle of t
T9388	17609-17624	UMLS/C0242692	denotes	l respiration r
T9389	15969-15980	UMLS/C1705242	denotes	e or volume
T9390	15034-15042	UMLS/C1550141	denotes	antitati
T9391	15245-15253	UMLS/C1550141	denotes	s in the
T9392	15660-15668	UMLS/C1550141	denotes	n of Tfa
T9393	14989-14997	UMLS/C1707455	denotes	e- match
T9394	15222-15230	UMLS/C1707455	denotes	s indepe
T9395	15635-15643	UMLS/C1707455	denotes	n additi
T9396	17827-17838	UMLS/C0035203	denotes	succinate a
T9397	18055-18066	UMLS/C0035203	denotes	ed in PGC-1
T9398	15297-15306	UMLS/C1705248	denotes	ent with
T9399	17594-17601	UMLS/C0205349	denotes	e, mito
T9400	18107-18114	UMLS/C0205349	denotes	ith the
T9401	14354-14362	UMLS/C2347472	denotes	Abnormal
T9402	15494-15506	UP/P00145	denotes	idase IV) an
T9403	14952-14965	UMLS/C0242694	denotes	GC-1α−/− mice
T9404	15155-15161	UMLS/C0242694	denotes	signif
T9405	15598-15611	UMLS/C0242694	denotes	e compared wi
T9406	15820-15826	UMLS/C0242694	denotes	for de
T9407	15946-15952	UMLS/C0242694	denotes	chondr
T9408	17729-17742	UMLS/C0242694	denotes	icant defect
T9409	17747-17753	UMLS/C0242694	denotes	ate 3
T9410	15494-15506	UP/P19974	denotes	idase IV) an
T9411	15269-15276	UMLS/C0443172	denotes	mponent
T9412	15852-15861	UMLS/C1706376	denotes	enesis (F
T9413	14755-14759	UMLS/C1705811	denotes	mit
T9414	14755-14759	UMLS/C1705810	denotes	mit
T9415	14735-14740	UMLS/C1550718	denotes	nt ro
T9416	14417-14424	UMLS/C1553889	denotes	al hist
T9417	15010-15014	UMLS/C1114365	denotes	cont
T9418	14755-14759	UMLS/C1705812	denotes	mit
T9419	15015-15022	UMLS/C1708943	denotes	ols (Fi
T9420	14755-14759	UMLS/C1705809	denotes	mit
T9421	15673-15681	UMLS/C1883712	denotes	known PG
T9422	14788-14796	UMLS/C1705273	denotes	nesis, w
T9423	17581-17589	UMLS/C1705273	denotes	PGC-1α−/
T9424	15001-15005	UMLS/C1522384	denotes	GC-1
T9425	14918-14923	UMLS/C0205388	denotes	mitoc
T9426	14735-14740	UMLS/C1442162	denotes	nt ro
T9427	17958-17966	UMLS/C0150312	denotes	otypes,
T9428	14533-14548	UMLS/C1550659	denotes	tal muscle of t
T9429	17609-17624	UMLS/C1550659	denotes	l respiration r
T9430	17686-17694	UMLS/C0079809	denotes	scle. In
T9431	17827-17838	UMLS/C0282636	denotes	succinate a
T9432	18055-18066	UMLS/C0282636	denotes	ed in PGC-1
T9433	14370-14383	UMLS/C0026237	denotes	Mitochondrial
T9434	14774-14787	UMLS/C0026237	denotes	tion and biog
T9435	14825-14838	UMLS/C0026237	denotes	astructure in
T9436	14936-14948	UMLS/C0026237	denotes	leus muscle
T9437	15162-15174	UMLS/C0026237	denotes	cantly lower
T9438	15348-15361	UMLS/C0026237	denotes	ound a reduct
T9439	15876-15889	UMLS/C0026237	denotes	ontrast to th
T9440	15984-15997	UMLS/C0026237	denotes	sity were not
T9441	17567-17580	UMLS/C0026237	denotes	tal muscle of
T9442	17649-17662	UMLS/C0026237	denotes	tissue strips
T9443	14861-14869	UMLS/C2347946	denotes	Electron
T9444	14523-14528	UMLS/C0018787	denotes	and
T9445	16045-16050	UMLS/C0018787	denotes	d dat
T9446	15015-15022	UMLS/C0336766	denotes	ols (Fi
T9447	15494-15506	UP/P99999	denotes	idase IV) an
T9448	18043-18051	UMLS/C0010222	denotes	cantly a
T9449	15494-15506	UP/P00059	denotes	idase IV) an
T9450	15852-15861	UMLS/C0441712	denotes	enesis (F
T9451	15494-15506	UP/P68519	denotes	idase IV) an
T9452	15494-15506	UP/Q5RFH4	denotes	idase IV) an
T9453	15494-15506	UP/P00049	denotes	idase IV) an
T9454	15034-15042	UMLS/C1547100	denotes	antitati
T9455	15245-15253	UMLS/C1547100	denotes	s in the
T9456	15660-15668	UMLS/C1547100	denotes	n of Tfa
T9457	14755-14759	UMLS/C1704326	denotes	mit
T9458	15137-15143	UMLS/C1690016	denotes	mitoc
T9459	16016-16022	UMLS/C1690016	denotes	of PGC
T9461	15494-15506	UP/P00042	denotes	idase IV) an
T9462	15511-15529	UP/Q51700	denotes	dative phosphoryla
T9463	15494-15506	UP/Q4N594	denotes	idase IV) an
T9464	17802-17807	UMLS/C1301808	denotes	sal),
T9465	17924-17929	UMLS/C1301808	denotes	were
T9466	15838-15841	UMLS/C0205447	denotes	cho
T9467	15416-15423	UMLS/C0521447	denotes	s invol
T9468	14370-14383	UMLS/C0521451	denotes	Mitochondrial
T9469	14774-14787	UMLS/C0521451	denotes	tion and biog
T9470	14825-14838	UMLS/C0521451	denotes	astructure in
T9471	15348-15361	UMLS/C0521451	denotes	ound a reduct
T9472	15876-15889	UMLS/C0521451	denotes	ontrast to th
T9473	15984-15997	UMLS/C0521451	denotes	sity were not
T9474	17567-17580	UMLS/C0521451	denotes	tal muscle of
T9475	17649-17662	UMLS/C0521451	denotes	tissue strips
T9476	15494-15506	UP/P00021	denotes	idase IV) an
T9477	14463-14468	UMLS/C0439659	denotes	to e
T9478	14490-14496	UMLS/C1621966	denotes	h defe
T9479	15494-15506	UP/P00064	denotes	idase IV) an
T9480	14425-14435	UMLS/C0205462	denotes	logic anal
T9481	15254-15265	UMLS/C1549571	denotes	myofibrilla
T9482	18012-18021	UMLS/C1285573	denotes	ATP prod
T9483	14384-14393	UMLS/C1285572	denotes	Phenotype
T9484	15494-15506	UP/Q6C9Q0	denotes	idase IV) an
T9485	14788-14796	UMLS/C0542341	denotes	nesis, w
T9486	17581-17589	UMLS/C0542341	denotes	PGC-1α−/
T9487	15494-15506	UP/P00022	denotes	idase IV) an
T9488	15494-15506	UP/P00058	denotes	idase IV) an
T9489	15494-15506	UP/O93863	denotes	idase IV) an
T9490	15494-15506	UP/P00079	denotes	idase IV) an
T9491	14728-14732	UMLS/C1511726	denotes	impo
T9492	17539-17543	UMLS/C1511726	denotes	ion
T9493	14504-14509	UMLS/C0037088	denotes	in p
T9494	15377-15382	UMLS/C0037088	denotes	ssion
T9495	15494-15506	UP/P32556	denotes	idase IV) an
T9496	15494-15506	UP/P00004	denotes	idase IV) an
T9497	15430-15438	UMLS/C0679058	denotes	mitochon
T9498	15494-15506	UP/P68100	denotes	idase IV) an
T9499	15034-15042	UMLS/C0243148	denotes	antitati
T9500	15245-15253	UMLS/C0243148	denotes	s in the
T9501	15660-15668	UMLS/C0243148	denotes	n of Tfa
T9502	15494-15506	UP/P68518	denotes	idase IV) an
T9503	15494-15506	UP/P62773	denotes	idase IV) an
T9504	14599-14612	UMLS/C1704258	denotes	ies in cellul
T9505	15494-15506	UP/O13393	denotes	idase IV) an
T9506	15494-15506	UP/Q9RQB9	denotes	idase IV) an
T9507	15494-15506	UP/P00067	denotes	idase IV) an
T9508	15494-15506	UP/P00152	denotes	idase IV) an
T9509	15254-15265	UMLS/C1608386	denotes	myofibrilla
T9510	14801-14811	UMLS/C0005495	denotes	mined mito
T9511	15362-15372	UMLS/C0005495	denotes	on in the
T9512	15890-15900	UMLS/C0005495	denotes	results w
T9513	14928-14935	UMLS/C0700321	denotes	ia in s
T9514	15494-15506	UP/P00013	denotes	idase IV) an
T9515	15385-15394	UMLS/C0301630	denotes	nuclear
T9516	15494-15506	UP/P00060	denotes	idase IV) an
T9517	15791-15801	UMLS/C0205216	denotes	ding one p
T9518	14616-14627	UMLS/C1516377	denotes	y, cell siz
T9519	17715-17723	UMLS/C1521827	denotes	mice, a
T9520	15494-15506	UP/Q96VP3	denotes	idase IV) an
T9521	14513-14522	UMLS/C0443281	denotes	atal hear
T9522	15494-15506	UP/P81280	denotes	idase IV) an
T9523	15494-15506	UP/P00025	denotes	idase IV) an
T9524	14436-14444	UMLS/C0936012	denotes	ses were
T9525	14900-14908	UMLS/C0936012	denotes	fewer an
T9526	15494-15506	UP/P00068	denotes	idase IV) an
T9527	15494-15506	UP/P00024	denotes	idase IV) an
T9528	15723-15729	UMLS/C1521840	denotes	replic
T9529	14909-14917	UMLS/C0443289	denotes	smaller
T9530	14504-14509	UMLS/C0243095	denotes	in p
T9531	15377-15382	UMLS/C0243095	denotes	ssion
T9532	17869-17877	UMLS/C0442726	denotes	ate 4 re
T9533	15254-15265	UMLS/C0332291	denotes	myofibrilla
T9534	15933-15940	UMLS/C1274040	denotes	ences i
T9535	18145-18152	UMLS/C1274040	denotes	on in m
T9536	15933-15940	UMLS/C0332294	denotes	ences i
T9537	18145-18152	UMLS/C0332294	denotes	on in m
T9538	15193-15198	UMLS/C0234886	denotes	compa
T9539	15193-15198	UMLS/C0205251	denotes	compa
T9540	15297-15306	UMLS/C0449432	denotes	ent with
T9541	15193-15198	UMLS/C1611820	denotes	compa
T9542	15320-15335	UMLS/C0332290	denotes	tochondrial bio
T9543	18157-18172	UMLS/C0332290	denotes	ondrial volume
T9544	14417-14424	UMLS/C0205246	denotes	al hist
T9545	15723-15729	UMLS/C0599894	denotes	replic
T9546	17802-17807	UMLS/C1552743	denotes	sal),
T9547	17924-17929	UMLS/C1552743	denotes	were
T9548	15494-15506	UMLS/C1153524	denotes	idase IV) an
T9549	14928-14935	UMLS/C2700395	denotes	ia in s
T9550	15034-15042	UMLS/C0332298	denotes	antitati
T9551	15245-15253	UMLS/C0332298	denotes	s in the
T9552	15660-15668	UMLS/C0332298	denotes	n of Tfa
T9553	15494-15506	UP/P00008	denotes	idase IV) an
T9554	15494-15506	UP/P21665	denotes	idase IV) an
T9555	15494-15506	UP/P00065	denotes	idase IV) an
T9556	18089-18092	UMLS/C1518422	denotes	s a
T9557	15494-15506	UP/Q869N1	denotes	idase IV) an
T9558	15128-15136	UMLS/C0007634	denotes	of soleu
T9559	15137-15143	UMLS/C0449468	denotes	mitoc
T9560	16016-16022	UMLS/C0449468	denotes	of PGC
T9561	15494-15506	UP/P00014	denotes	idase IV) an
T9562	15494-15506	UP/P00037	denotes	idase IV) an
T9563	17811-17814	UMLS/C0004374	denotes	de
T9564	15494-15506	UP/A2Y4S9	denotes	idase IV) an
T9565	15511-15529	UP/P24474	denotes	dative phosphoryla
T9566	15494-15506	UP/Q4HVX7	denotes	idase IV) an
T9567	14879-14887	UMLS/C0013850	denotes	ic analy
T9568	15088-15096	UMLS/C0013850	denotes	firmed t
T9569	15269-15276	UMLS/C0025320	denotes	mponent
T9570	15933-15940	UMLS/C1546471	denotes	ences i
T9571	18145-18152	UMLS/C1546471	denotes	on in m
T9572	14879-14887	UMLS/C0013852	denotes	ic analy
T9573	15088-15096	UMLS/C0013852	denotes	firmed t
T9574	15494-15506	UP/P00019	denotes	idase IV) an
T9575	14888-14899	UMLS/C0205288	denotes	is revealed
T9576	14533-14548	UMLS/C1280260	denotes	tal muscle of t
T9577	17609-17624	UMLS/C1280260	denotes	l respiration r
T9578	15494-15506	UP/P00011	denotes	idase IV) an
T9579	15494-15506	UP/P00063	denotes	idase IV) an
T9580	15494-15506	UP/P00051	denotes	idase IV) an
T9581	15494-15506	UP/P00146	denotes	idase IV) an
T9582	15494-15506	UP/P00041	denotes	idase IV) an
T9583	15385-15394	UMLS/C0441610	denotes	nuclear
T9584	15001-15005	UMLS/C1314687	denotes	GC-1
T9585	15957-15968	UMLS/C1546944	denotes	ltrastructu
T9586	17780-17791	UMLS/C1546944	denotes	n, but not
T9587	15051-15053	UMLS/C1706447	denotes	me
T9588	18070-18073	UMLS/C1366832	denotes	mi
T9589	15511-15529	UP/P24040	denotes	dative phosphoryla
T9590	15494-15506	UP/P00154	denotes	idase IV) an
T9591	15709-15714	UMLS/C0205309	denotes	chond
T9592	15511-15529	UP/P72181	denotes	dative phosphoryla
T9593	15494-15506	UP/P00153	denotes	idase IV) an
T9594	15193-15198	UMLS/C1299352	denotes	compa
T9595	15494-15506	UP/P00074	denotes	idase IV) an
T9596	15494-15506	UP/P25400	denotes	idase IV) an
T9597	15494-15506	UP/P12831	denotes	idase IV) an
T9598	15494-15506	UP/Q0DI31	denotes	idase IV) an
T9599	15494-15506	UP/P00002	denotes	idase IV) an
T9600	15034-15042	UMLS/C2587213	denotes	antitati
T9601	15245-15253	UMLS/C2587213	denotes	s in the
T9602	15660-15668	UMLS/C2587213	denotes	n of Tfa
T9603	15494-15506	UP/Q52V09	denotes	idase IV) an
T9604	15494-15506	UP/P00030	denotes	idase IV) an
T9605	15494-15506	UP/P56205	denotes	idase IV) an
T9606	14629-14638	UMLS/C0162658	denotes	or extra
T9607	18074-18084	UMLS/C1548180	denotes	e. These r
T9608	17708-17714	UMLS/C1705490	denotes	-1α−/−
T9609	15494-15506	UP/P00007	denotes	idase IV) an
T9610	15494-15506	UP/P68517	denotes	idase IV) an
T11734	21712-21720	UMLS/C0015259	denotes	d, the P
T11735	21813-21822	UMLS/C0015259	denotes	mat. PGC-
T11736	21987-21995	UMLS/C0015259	denotes	re 4B).
T11737	22379-22387	UMLS/C1522729	denotes	0.9 ± 2.
T11738	22088-22092	UMLS/C0445247	denotes	dat
T11739	21441-21445	UMLS/C0541749	denotes	ns,
T11740	21712-21720	UMLS/C1522704	denotes	d, the P
T11741	21813-21822	UMLS/C1522704	denotes	mat. PGC-
T11742	21987-21995	UMLS/C1522704	denotes	re 4B).
T11743	18555-18559	UMLS/C2347634	denotes	r of
T11744	18523-18532	UMLS/C0015272	denotes	a signifi
T11745	21930-21939	UMLS/C0015272	denotes	, 64 ± 6
T11746	20834-20846	UMLS/C0237593	denotes	battery of
T11747	18329-18331	UMLS/C0319022	denotes	rt
T11748	18620-18622	UMLS/C0319022	denotes	-1
T11749	18767-18769	UMLS/C0319022	denotes	en
T11750	18817-18819	UMLS/C0319022	denotes	ca
T11751	19286-19288	UMLS/C0319022	denotes	ld
T11752	20904-20906	UMLS/C0319022	denotes	im
T11753	21301-21303	UMLS/C0319022	denotes	co
T11754	21438-21440	UMLS/C0319022	denotes	re
T11755	21463-21465	UMLS/C0319022	denotes	t
T11756	21661-21663	UMLS/C0319022	denotes	ci
T11757	21771-21773	UMLS/C0319022	denotes	ll
T11758	21968-21970	UMLS/C0319022	denotes	,
T11759	22190-22192	UMLS/C0319022	denotes	te
T11760	22526-22528	UMLS/C0319022	denotes	li
T11761	22604-22606	UMLS/C0319022	denotes	as
T11762	22665-22667	UMLS/C0319022	denotes	ie
T11763	22746-22748	UMLS/C0319022	denotes	ph
T11764	23219-23221	UMLS/C0319022	denotes	to
T11765	21608-21620	UMLS/C0700114	denotes	evaluate the
T11766	18549-18554	UMLS/C1548802	denotes	numb
T11767	22441-22446	UMLS/C1548802	denotes	(141
T11768	23162-23167	UMLS/C1548802	denotes	her w
T11769	18695-18715	UMLS/C0015328	denotes	behavior showed tha
T11770	18549-18554	UMLS/C1619811	denotes	numb
T11771	22441-22446	UMLS/C1619811	denotes	(141
T11772	23162-23167	UMLS/C1619811	denotes	her w
T11773	22315-22326	UMLS/C0944911	denotes	metry. VO2m
T11774	21734-21742	UMLS/C1516048	denotes	were exe
T11775	20884-20889	UMLS/C0039593	denotes	e the
T11776	18683-18691	UMLS/C1524024	denotes	explora
T11777	18549-18554	UMLS/C0441994	denotes	numb
T11778	22441-22446	UMLS/C0441994	denotes	(141
T11779	23162-23167	UMLS/C0441994	denotes	her w
T11780	18394-18398	UMLS/C1705117	denotes	we
T11781	20884-20889	UMLS/C0013702	denotes	e the
T11782	22786-22792	UMLS/C0039614	denotes	as no
T11783	18271-18277	UMLS/C1709287	denotes	r and
T11784	18560-18566	UMLS/C1709287	denotes	ambula
T11785	19384-19394	UMLS/C0558058	denotes	s increase
T11786	22625-22631	UMLS/C1995013	denotes	pacity
T11787	22940-22947	UMLS/C1995013	denotes	cent of
T11788	22679-22690	UMLS/C1292856	denotes	is dependen
T11789	22873-22884	UMLS/C1292856	denotes	+/+ control
T11790	22694-22702	UMLS/C1546680	denotes	on mitoc
T11791	22948-22956	UMLS/C1546680	denotes	initial
T11792	18449-18455	UMLS/C1561960	denotes	d usin
T11793	22885-22891	UMLS/C1561960	denotes	. Howe
T11794	20894-20903	UMLS/C0884358	denotes	ral senso
T11795	18513-18517	UMLS/C1706180	denotes	exhi
T11796	23285-23293	UMLS/C1883357	denotes	ary for
T11797	22776-22782	UMLS/C0205549	denotes	d, the
T11798	23110-23116	UMLS/C0205549	denotes	rols (
T11799	21326-21332	UMLS/C1705053	denotes	ce the
T11800	21500-21507	UMLS/C1705053	denotes	t impai
T11801	18449-18455	UMLS/C2347804	denotes	d usin
T11802	22885-22891	UMLS/C2347804	denotes	. Howe
T11803	21079-21087	UMLS/C1710360	denotes	lined sc
T11804	21979-21986	UMLS/C0035953	denotes	s; Fig
T11805	21097-21107	UMLS/C1158830	denotes	(unpublis
T11806	18513-18517	UMLS/C0325595	denotes	exhi
T11807	18449-18455	UMLS/C0439531	denotes	d usin
T11808	22885-22891	UMLS/C0439531	denotes	. Howe
T11809	21089-21096	UMLS/C1551030	denotes	en test
T11810	18242-18253	UMLS/C0000768	denotes	mality in m
T11811	23312-23325	UMLS/C0000768	denotes	on of skeleta
T11812	18242-18253	UMLS/C0000769	denotes	mality in m
T11813	23312-23325	UMLS/C0000769	denotes	on of skeleta
T11814	19147-19153	UMLS/C0441833	denotes	ggest
T11815	21395-21401	UMLS/C0441833	denotes	climb
T11816	21089-21096	UMLS/C0600108	denotes	en test
T11817	19162-19164	UP/P26783	denotes	ge
T11818	18903-18908	UMLS/C0680968	denotes	time
T11819	22315-22326	UMLS/C1305866	denotes	metry. VO2m
T11820	22632-22644	UMLS/C0231230	denotes	to generate
T11821	22926-22936	UMLS/C0079411	denotes	ned as the
T11822	21596-21604	UMLS/C0011155	denotes	To furt
T11823	21979-21986	UMLS/C0600140	denotes	s; Fig
T11824	21326-21332	UMLS/C0199230	denotes	ce the
T11825	21500-21507	UMLS/C0199230	denotes	t impai
T11826	21221-21227	UMLS/C1554187	denotes	− mice
T11827	23024-23034	UMLS/C1522618	denotes	was signif
T11828	18403-18411	UMLS/C1879489	denotes	red loco
T11829	22265-22273	UMLS/C1879489	denotes	e treadm
T11830	22343-22351	UMLS/C1879489	denotes	tly lowe
T11831	18998-19002	UMLS/C0017446	denotes	ough
T11832	19309-19313	UMLS/C0017446	denotes	he p
T11833	18190-18205	UMLS/C1546780	denotes	Skeletal Muscle
T11834	18306-18321	UMLS/C1546780	denotes	tal muscle led
T11835	18353-18368	UMLS/C1546780	denotes	tal muscle phen
T11836	21685-21700	UMLS/C1546780	denotes	PGC-1α−/− mice
T11837	23329-23344	UMLS/C1546780	denotes	scle to physiol
T11838	18683-18691	UMLS/C0002778	denotes	explora
T11839	18190-18205	UMLS/C0242692	denotes	Skeletal Muscle
T11840	18306-18321	UMLS/C0242692	denotes	tal muscle led
T11841	18353-18368	UMLS/C0242692	denotes	tal muscle phen
T11842	21685-21700	UMLS/C0242692	denotes	PGC-1α−/− mice
T11843	23329-23344	UMLS/C0242692	denotes	scle to physiol
T11844	21340-21344	UMLS/C1522425	denotes	did
T11845	20865-20869	UMLS/C0015726	denotes	to
T11846	21721-21729	UMLS/C1516240	denotes	C-1α−/−
T11847	21959-21967	UMLS/C1516240	denotes	α+/+ mic
T11848	22219-22227	UMLS/C1516240	denotes	f body w
T11849	22737-22745	UMLS/C1516240	denotes	initial
T11850	18555-18559	UMLS/C1704970	denotes	r of
T11851	18928-18932	UMLS/C0040223	denotes	igni
T11852	21424-21429	UMLS/C0040223	denotes	0° in
T11853	18182-18189	UMLS/C0205349	denotes	Altered
T11854	19395-19402	UMLS/C0205349	denotes	fear.
T11855	22703-22716	UMLS/C0242694	denotes	ondrial ATP p
T11856	21433-21437	UMLS/C1883727	denotes	ed s
T11857	23035-23040	UMLS/C1637833	denotes	cantl
T11858	21979-21986	UMLS/C0011991	denotes	s; Fig
T11859	18928-18932	UMLS/C0449243	denotes	igni
T11860	21424-21429	UMLS/C0449243	denotes	0° in
T11861	19195-19202	UMLS/C1553889	denotes	een aff
T11862	20928-20935	UMLS/C1553889	denotes	PGC-1α−
T11863	21925-21928	UMLS/C1114365	denotes	mi
T11864	22166-22169	UMLS/C1114365	denotes	ion
T11865	20855-20864	UMLS/C0442808	denotes	performe
T11866	20855-20864	UMLS/C0442805	denotes	performe
T11867	23016-23023	UMLS/C0015672	denotes	ctions,
T11868	23120-23129	UMLS/C0015672	denotes	± 2.9%)
T11869	19361-19372	UMLS/C1621832	denotes	red emotion
T11870	22860-22865	UMLS/C0205390	denotes	ce an
T11871	18883-18888	UMLS/C0205388	denotes	sign
T11872	20884-20889	UMLS/C0183885	denotes	e the
T11873	18190-18205	UMLS/C1550659	denotes	Skeletal Muscle
T11874	18306-18321	UMLS/C1550659	denotes	tal muscle led
T11875	18353-18368	UMLS/C1550659	denotes	tal muscle phen
T11876	21685-21700	UMLS/C1550659	denotes	PGC-1α−/− mice
T11877	23329-23344	UMLS/C1550659	denotes	scle to physiol
T11878	21457-21462	UMLS/C0561942	denotes	ces o
T11879	22694-22702	UMLS/C0205409	denotes	on mitoc
T11880	22948-22956	UMLS/C0205409	denotes	initial
T11881	18757-18766	UMLS/C2347948	denotes	into the
T11882	19248-19258	UMLS/C2347948	denotes	to go into
T11883	23035-23040	UMLS/C1552854	denotes	cantl
T11884	21433-21437	UMLS/C1515187	denotes	ed s
T11885	23303-23311	UMLS/C1441672	denotes	adaptat
T11886	18271-18277	UMLS/C1554106	denotes	r and
T11887	18560-18566	UMLS/C1554106	denotes	ambula
T11888	19147-19153	UMLS/C1552839	denotes	ggest
T11889	21395-21401	UMLS/C1552839	denotes	climb
T11890	22764-22773	UMLS/C1719822	denotes	lation pe
T11891	23092-23101	UMLS/C1719822	denotes	to PGC-1
T11892	21712-21720	UMLS/C0452240	denotes	d, the P
T11893	21813-21822	UMLS/C0452240	denotes	mat. PGC-
T11894	21987-21995	UMLS/C0452240	denotes	re 4B).
T11895	21470-21473	UMLS/C1552827	denotes	ver
T11896	20865-20869	UMLS/C1961839	denotes	to
T11897	21608-21620	UMLS/C1549570	denotes	evaluate the
T11898	22656-22664	UMLS/C1706817	denotes	ing a se
T11899	21779-21782	UMLS/C0444930	denotes	atu
T11900	22245-22263	UMLS/C0030055	denotes	was measured with
T11901	22292-22298	UMLS/C0030054	denotes	l usin
T11902	22492-22494	UMLS/C0030054	denotes	d
T11903	22566-22568	UMLS/C0030054	denotes	ti
T11904	22650-22655	UMLS/C0441722	denotes	follo
T11905	22758-22763	UMLS/C0441722	denotes	stim
T11906	22920-22925	UMLS/C0441722	denotes	, def
T11907	23076-23081	UMLS/C0441722	denotes	± 1.5
T11908	23130-23142	UMLS/C1140999	denotes	Figure 4C).
T11909	22394-22414	UMLS/C0006781	denotes	· kg−1 · min−1) com
T11910	19173-19177	UMLS/C1511726	denotes	ivit
T11911	21162-21166	UMLS/C1511726	denotes	ns w
T11912	22183-22187	UMLS/C1511726	denotes	mill
T11913	18782-18788	UMLS/C1552820	denotes	ield”
T11914	19147-19153	UMLS/C0439745	denotes	ggest
T11915	21395-21401	UMLS/C0439745	denotes	climb
T11916	21575-21583	UMLS/C1705922	denotes	or these
T11917	22088-22092	UMLS/C1692345	denotes	dat
T11918	19375-19383	UMLS/C2362652	denotes	ty such
T11919	18394-18398	UMLS/C1261552	denotes	we
T11920	20855-20864	UMLS/C0205217	denotes	performe
T11921	21779-21782	UMLS/C1522314	denotes	atu
T11922	22776-22782	UMLS/C2348044	denotes	d, the
T11923	23110-23116	UMLS/C2348044	denotes	rols (
T11924	21566-21574	UMLS/C0684336	denotes	onsible
T11925	18998-19002	UMLS/C1504310	denotes	ough
T11926	19309-19313	UMLS/C1504310	denotes	he p
T11927	19336-19342	UMLS/C1527428	denotes	possi
T11928	21304-21310	UMLS/C1527428	denotes	trols
T11929	18683-18691	UMLS/C0936012	denotes	explora
T11930	18449-18455	UMLS/C0025344	denotes	d usin
T11931	22885-22891	UMLS/C0025344	denotes	. Howe
T11932	19083-19087	UMLS/C0680812	denotes	igni
T11933	23035-23040	UMLS/C0021200	denotes	cantl
T11934	22093-22099	UMLS/C0332294	denotes	). To
T11935	23276-23283	UMLS/C0332294	denotes	is nece
T11936	22093-22099	UMLS/C1274040	denotes	). To
T11937	23276-23283	UMLS/C1274040	denotes	is nece
T11938	18549-18554	UMLS/C0205251	denotes	numb
T11939	22441-22446	UMLS/C0205251	denotes	(141
T11940	23162-23167	UMLS/C0205251	denotes	her w
T11941	21221-21227	UMLS/C0445145	denotes	− mice
T11942	18549-18554	UMLS/C1611820	denotes	numb
T11943	22441-22446	UMLS/C1611820	denotes	(141
T11944	23162-23167	UMLS/C1611820	denotes	her w
T11945	19195-19202	UMLS/C0205246	denotes	een aff
T11946	20928-20935	UMLS/C0205246	denotes	PGC-1α−
T11947	18271-18277	UMLS/C0237753	denotes	r and
T11948	18560-18566	UMLS/C0237753	denotes	ambula
T11949	19162-19164	UMLS/C1419032	denotes	ge
T11950	21340-21344	UMLS/C0870371	denotes	did
T11951	22379-22387	UMLS/C0442711	denotes	0.9 ± 2.
T11952	18650-18658	UMLS/C0332298	denotes	igure 4)
T11953	18820-18828	UMLS/C0332298	denotes	ly, PGC-
T11954	21056-21064	UMLS/C0332298	denotes	on, and
T11955	21363-21371	UMLS/C0332298	denotes	imes it
T11956	22540-22548	UMLS/C0332298	denotes	e respon
T11957	22997-23005	UMLS/C0332298	denotes	of fatig
T11958	23233-23241	UMLS/C0332298	denotes	ructure
T11959	21838-21847	UMLS/C2712999	denotes	mo of age
T11960	18386-18393	UMLS/C0205265	denotes	al step
T11961	22852-22859	UMLS/C0205265	denotes	1α−/− m
T11962	23068-23075	UMLS/C0205265	denotes	e (14.6
T11963	21221-21227	UMLS/C0205266	denotes	− mice
T11964	23042-23049	UMLS/C1704788	denotes	lower i
T11965	19111-19114	UMLS/C1518422	denotes	en
T11966	22764-22773	UMLS/C0332282	denotes	lation pe
T11967	23092-23101	UMLS/C0332282	denotes	to PGC-1
T11968	20873-20880	UMLS/C1704779	denotes	her eva
T11969	18770-18777	UMLS/C0332286	denotes	er of t
T11970	19289-19296	UMLS/C0332286	denotes	and thu
T11971	22764-22773	UMLS/C0332283	denotes	lation pe
T11972	23092-23101	UMLS/C0332283	denotes	to PGC-1
T11973	22694-22702	UMLS/C1764827	denotes	on mitoc
T11974	22948-22956	UMLS/C1764827	denotes	initial
T11975	22093-22099	UMLS/C1546471	denotes	). To
T11976	23276-23283	UMLS/C1546471	denotes	is nece
T11977	19218-19221	UMLS/C0337876	denotes	uct
T11978	18422-18437	UMLS/C0683317	denotes	ity levels over
T11979	19203-19217	UMLS/C0683317	denotes	cted by the re
T11980	21326-21332	UMLS/C1710031	denotes	ce the
T11981	21500-21507	UMLS/C1710031	denotes	t impai
T11982	21097-21107	UMLS/C0589507	denotes	(unpublis
T11983	22118-22125	UMLS/C0332239	denotes	ercise
T11984	23024-23034	UMLS/C0237834	denotes	was signif
T11985	18966-18973	UMLS/C1806781	denotes	entral
T11986	21193-21215	UMLS/C0589515	denotes	mice. However, the PG
T11987	21326-21332	UMLS/C0430054	denotes	ce the
T11988	21500-21507	UMLS/C0430054	denotes	t impai
T11989	18549-18554	UMLS/C1299352	denotes	numb
T11990	22441-22446	UMLS/C1299352	denotes	(141
T11991	23162-23167	UMLS/C1299352	denotes	her w
T11992	18555-18559	UMLS/C2348143	denotes	r of
T11993	22237-22244	UMLS/C0806909	denotes	minute)
T11994	18182-18189	UMLS/C0221099	denotes	Altered
T11995	19395-19402	UMLS/C0221099	denotes	fear.
T11996	21566-21574	UMLS/C0221099	denotes	onsible
T11997	18650-18658	UMLS/C1882979	denotes	igure 4)
T11998	18820-18828	UMLS/C1882979	denotes	ly, PGC-
T11999	21056-21064	UMLS/C1882979	denotes	on, and
T12000	21363-21371	UMLS/C1882979	denotes	imes it
T12001	22540-22548	UMLS/C1882979	denotes	e respon
T12002	22997-23005	UMLS/C1882979	denotes	of fatig
T12003	23233-23241	UMLS/C1882979	denotes	ructure
T12004	21136-21148	UMLS/C0871311	denotes	veral sensor
T12005	21541-21552	UMLS/C0871311	denotes	in coordina
T12006	18513-18517	UMLS/C0024554	denotes	exhi
T12007	22656-22664	UMLS/C0871261	denotes	ing a se
T12008	22237-22244	UMLS/C1552615	denotes	minute)
T12009	21779-21782	UMLS/C1272693	denotes	atu
T12010	21779-21782	UMLS/C1561490	denotes	atu
T12011	18369-18378	UMLS/C1314763	denotes	type. As
T12012	20949-20958	UMLS/C1314763	denotes	fferences
T12013	21701-21710	UMLS/C1314763	denotes	To this
T12014	18782-18788	UMLS/C0205099	denotes	ield”
T12015	18990-18997	UMLS/C0205099	denotes	d,” alt
T12016	19301-19308	UMLS/C0205099	denotes	ain in
T12017	21942-21950	UMLS/C0522501	denotes	age-matc
T12018	19072-19082	UMLS/C0205100	denotes	” was not
T12019	21097-21107	UMLS/C1704686	denotes	(unpublis
T12020	22825-22828	UMLS/C0001480	denotes	mu
T12021	18928-18932	UMLS/C0392761	denotes	igni
T12022	21424-21429	UMLS/C0392761	denotes	0° in
T12023	22825-22828	UMLS/C1705556	denotes	mu
T12024	19232-19240	UMLS/C0392760	denotes	PGC-1α−
T12025	19147-19153	UMLS/C1522242	denotes	ggest
T12026	21395-21401	UMLS/C1522242	denotes	climb
T12027	18403-18411	UMLS/C0444706	denotes	red loco
T12028	22265-22273	UMLS/C0444706	denotes	e treadm
T12029	22343-22351	UMLS/C0444706	denotes	tly lowe
T12030	19178-19185	UMLS/C1705535	denotes	level
T12031	21169-21179	UMLS/C1705535	denotes	intact in
T12032	21553-21560	UMLS/C1705535	denotes	ion wer
T12033	18928-18932	UMLS/C1632851	denotes	igni
T12034	21424-21429	UMLS/C1632851	denotes	0° in
T12035	21097-21107	UMLS/C0678321	denotes	(unpublis
T12036	21951-21958	UMLS/C0392756	denotes	ed PGC-
T12037	18928-18932	UMLS/C1547403	denotes	igni
T12038	21424-21429	UMLS/C1547403	denotes	0° in
T12039	18449-18455	UMLS/C0221193	denotes	d usin
T12040	22885-22891	UMLS/C0221193	denotes	. Howe
T12041	23024-23034	UMLS/C0683598	denotes	was signif
T12042	21340-21344	UMLS/C0392744	denotes	did
T12043	21089-21096	UMLS/C0080331	denotes	en test
T12044	21575-21583	UMLS/C0808080	denotes	or these
T12045	19147-19153	UMLS/C1561557	denotes	ggest
T12046	21395-21401	UMLS/C1561557	denotes	climb
T12047	22607-22615	UMLS/C1947931	denotes	determin
T12048	18549-18554	UMLS/C1708760	denotes	numb
T12049	22441-22446	UMLS/C1708760	denotes	(141
T12050	23162-23167	UMLS/C1708760	denotes	her w
T12051	21979-21986	UMLS/C1947934	denotes	s; Fig
T12052	18974-18982	UMLS/C0012751	denotes	rea of t
T12053	19047-19055	UMLS/C0012751	denotes	pheral z
T12054	21340-21344	UMLS/C0205166	denotes	did
T12055	18386-18393	UMLS/C1561569	denotes	al step
T12056	22852-22859	UMLS/C1561569	denotes	1α−/− m
T12057	23068-23075	UMLS/C1561569	denotes	e (14.6
T12058	18449-18455	UMLS/C0332182	denotes	d usin
T12059	22885-22891	UMLS/C0332182	denotes	. Howe
T12060	22656-22664	UMLS/C1704632	denotes	ing a se
T12061	21848-21857	UMLS/C1947951	denotes	exhibite
T12062	18998-19002	UMLS/C0205146	denotes	ough
T12063	19309-19313	UMLS/C0205146	denotes	he p
T12064	20873-20880	UMLS/C0337088	denotes	her eva
T12065	18928-18932	UMLS/C1548318	denotes	igni
T12066	21424-21429	UMLS/C1548318	denotes	0° in
T12067	18438-18442	UMLS/C0205136	denotes	a 1-
T12068	20884-20889	UMLS/C0022885	denotes	e the
T12069	20894-20903	UMLS/C1550369	denotes	ral senso
T12070	22721-22731	UMLS/C0521095	denotes	tion. Duri
T12071	18412-18430	UMLS/C0026606	denotes	otor activity leve
T12072	21470-21473	UMLS/C0324740	denotes	ver
T12073	19232-19240	UMLS/C1314939	denotes	PGC-1α−
T12074	18889-18896	UMLS/C1705654	denotes	ficantl
T12075	18889-18896	UMLS/C1550548	denotes	ficantl
T12076	21294-21300	UMLS/C1299582	denotes	-1α+/+
T12077	21457-21462	UMLS/C2584300	denotes	ces o
T12078	19162-19164	UP/Q02471	denotes	ge
T12079	22202-22218	UMLS/C0001701	denotes	en per kilogram
T12080	18386-18393	UMLS/C1555582	denotes	al step
T12081	22852-22859	UMLS/C1555582	denotes	1α−/− m
T12082	23068-23075	UMLS/C1555582	denotes	e (14.6
T12083	22292-22298	UMLS/C2359957	denotes	l usin
T12084	22379-22387	UMLS/C2349977	denotes	0.9 ± 2.
T12085	18650-18658	UMLS/C0009932	denotes	igure 4)
T12086	18820-18828	UMLS/C0009932	denotes	ly, PGC-
T12087	21056-21064	UMLS/C0009932	denotes	on, and
T12088	21363-21371	UMLS/C0009932	denotes	imes it
T12089	22540-22548	UMLS/C0009932	denotes	e respon
T12090	22997-23005	UMLS/C0009932	denotes	of fatig
T12091	23233-23241	UMLS/C0009932	denotes	ructure
T12092	19147-19153	UMLS/C1552516	denotes	ggest
T12093	21395-21401	UMLS/C1552516	denotes	climb
T12094	19013-19018	UMLS/C1553496	denotes	s in
T12095	19321-19326	UMLS/C1553496	denotes	(thi
T12096	18386-18393	UMLS/C1705684	denotes	al step
T12097	22852-22859	UMLS/C1705684	denotes	1α−/− m
T12098	23068-23075	UMLS/C1705684	denotes	e (14.6
T12099	18386-18393	UMLS/C1705685	denotes	al step
T12100	22852-22859	UMLS/C1705685	denotes	1α−/− m
T12101	23068-23075	UMLS/C1705685	denotes	e (14.6
T12102	22679-22690	UMLS/C1948023	denotes	is dependen
T12103	22873-22884	UMLS/C1948023	denotes	+/+ control
T12104	21326-21332	UMLS/C0220909	denotes	ce the
T12105	21500-21507	UMLS/C0220909	denotes	t impai
T12106	21626-21637	UMLS/C1273518	denotes	tal muscle
T12107	21326-21332	UMLS/C0220908	denotes	ce the
T12108	21500-21507	UMLS/C0220908	denotes	t impai
T12109	18555-18559	UMLS/C0876919	denotes	r of
T12110	19232-19240	UMLS/C0001721	denotes	PGC-1α−
T12111	21326-21332	UMLS/C1305399	denotes	ce the
T12112	21500-21507	UMLS/C1305399	denotes	t impai
T12113	18403-18411	UMLS/C0242485	denotes	red loco
T12114	22265-22273	UMLS/C0242485	denotes	e treadm
T12115	22343-22351	UMLS/C0242485	denotes	tly lowe
T12116	22327-22337	UMLS/C0702093	denotes	x was sign
T12117	22104-22112	UMLS/C1301820	denotes	ify aero
T12118	22315-22326	UMLS/C0005910	denotes	metry. VO2m
T12119	21925-21928	UMLS/C0001792	denotes	mi
T12120	22166-22169	UMLS/C0001792	denotes	ion
T12121	18449-18455	UMLS/C1948053	denotes	d usin
T12122	22885-22891	UMLS/C1948053	denotes	. Howe
T12123	21608-21620	UMLS/C0242414	denotes	evaluate the
T12124	22093-22099	UMLS/C1280519	denotes	). To
T12125	23276-23283	UMLS/C1280519	denotes	is nece
T12126	22299-22302	UMLS/C0330664	denotes	in
T12127	21925-21928	UMLS/C0001779	denotes	mi
T12128	22166-22169	UMLS/C0001779	denotes	ion
T12129	21326-21332	UMLS/C1698960	denotes	ce the
T12130	21500-21507	UMLS/C1698960	denotes	t impai
T12131	18513-18517	UMLS/C0086582	denotes	exhi
T12132	18549-18554	UMLS/C1550472	denotes	numb
T12133	22441-22446	UMLS/C1550472	denotes	(141
T12134	23162-23167	UMLS/C1550472	denotes	her w
T12135	21925-21928	UMLS/C0001811	denotes	mi
T12136	22166-22169	UMLS/C0001811	denotes	ion
T12137	22104-22112	UMLS/C1706701	denotes	ify aero
T12138	19218-19221	UMLS/C0454788	denotes	uct
T12139	18340-18348	UMLS/C0220825	denotes	ate the
T12140	20915-20923	UMLS/C0220825	denotes	otype of
T12141	21672-21680	UMLS/C0220825	denotes	sessed i
T12142	22616-22624	UMLS/C0220825	denotes	d. The c
T12143	21838-21847	UMLS/C0184069	denotes	mo of age
T12144	18369-18378	UMLS/C0031437	denotes	type. As
T12145	20949-20958	UMLS/C0031437	denotes	fferences
T12146	21701-21710	UMLS/C0031437	denotes	To this
T12147	21596-21604	UMLS/C0162429	denotes	To furt
T12148	22625-22631	UMLS/C0026845	denotes	pacity
T12149	22940-22947	UMLS/C0026845	denotes	cent of
T12150	19013-19018	UMLS/C0440042	denotes	s in
T12151	19321-19326	UMLS/C0440042	denotes	(thi
T12152	19032-19043	UMLS/C1705241	denotes	led in the
T12153	20990-21001	UMLS/C1705241	denotes	ce and PGC-
T12154	21513-21524	UMLS/C1705241	denotes	rength rath
T12155	21648-21659	UMLS/C1705241	denotes	exercise ca
T12156	22906-22916	UMLS/C1705241	denotes	sistance i
T12157	20873-20880	UMLS/C1555716	denotes	her eva
T12158	23035-23040	UMLS/C0918012	denotes	cantl
T12159	18889-18896	UMLS/C1555714	denotes	ficantl
T12160	19032-19043	UMLS/C1705242	denotes	led in the
T12161	19129-19138	UMLS/C1705242	denotes	S2). Thes
T12162	20990-21001	UMLS/C1705242	denotes	ce and PGC-
T12163	21513-21524	UMLS/C1705242	denotes	rength rath
T12164	21648-21659	UMLS/C1705242	denotes	exercise ca
T12165	22906-22916	UMLS/C1705242	denotes	sistance i
T12166	18650-18658	UMLS/C1550141	denotes	igure 4)
T12167	18820-18828	UMLS/C1550141	denotes	ly, PGC-
T12168	21056-21064	UMLS/C1550141	denotes	on, and
T12169	21363-21371	UMLS/C1550141	denotes	imes it
T12170	22540-22548	UMLS/C1550141	denotes	e respon
T12171	22997-23005	UMLS/C1550141	denotes	of fatig
T12172	23233-23241	UMLS/C1550141	denotes	ructure
T12173	18611-18619	UMLS/C1707455	denotes	o the PG
T12174	18808-18816	UMLS/C1707455	denotes	. Specif
T12175	22517-22525	UMLS/C1707455	denotes	fatigab
T12176	23210-23218	UMLS/C1707455	denotes	muscle m
T12177	18282-18302	UMLS/C0035203	denotes	ratory function in s
T12178	22860-22865	UMLS/C0585064	denotes	ce an
T12179	19162-19164	UMLS/C1179705	denotes	ge
T12180	22379-22387	UMLS/C1507394	denotes	0.9 ± 2.
T12181	21470-21473	UMLS/C1704458	denotes	ver
T12182	18490-18496	UMLS/C1704459	denotes	m. PGC
T12183	18941-18949	UMLS/C1555670	denotes	shorter
T12184	19056-19064	UMLS/C1555670	denotes	ne of th
T12185	18271-18277	UMLS/C0449788	denotes	r and
T12186	18560-18566	UMLS/C0449788	denotes	ambula
T12187	22292-22298	UMLS/C1547125	denotes	l usin
T12188	18403-18411	UMLS/C0079809	denotes	red loco
T12189	22265-22273	UMLS/C0079809	denotes	e treadm
T12190	22343-22351	UMLS/C0079809	denotes	tly lowe
T12191	18257-18270	UMLS/C0026237	denotes	hondrial numb
T12192	22811-22824	UMLS/C0026237	denotes	generation i
T12193	18606-18610	UMLS/C0564385	denotes	red
T12194	18394-18398	UMLS/C0454366	denotes	we
T12195	20884-20889	UMLS/C0392366	denotes	e the
T12196	23035-23040	UMLS/C0600653	denotes	cantl
T12197	20834-20846	UMLS/C0542317	denotes	battery of
T12198	18650-18658	UMLS/C1547100	denotes	igure 4)
T12199	18820-18828	UMLS/C1547100	denotes	ly, PGC-
T12200	21056-21064	UMLS/C1547100	denotes	on, and
T12201	21363-21371	UMLS/C1547100	denotes	imes it
T12202	22540-22548	UMLS/C1547100	denotes	e respon
T12203	22997-23005	UMLS/C1547100	denotes	of fatig
T12204	23233-23241	UMLS/C1547100	denotes	ructure
T12205	18490-18496	UMLS/C0449913	denotes	m. PGC
T12206	19147-19153	UMLS/C1257890	denotes	ggest
T12207	21395-21401	UMLS/C1257890	denotes	climb
T12208	22796-22805	UMLS/C1701901	denotes	erence in
T12209	21441-21445	UMLS/C0003629	denotes	ns,
T12210	18257-18270	UMLS/C0521451	denotes	hondrial numb
T12211	22811-22824	UMLS/C0521451	denotes	generation i
T12212	22694-22702	UMLS/C0370215	denotes	on mitoc
T12213	22948-22956	UMLS/C0370215	denotes	initial
T12214	18199-18214	UMLS/C0231484	denotes	Muscle Function
T12215	18490-18496	UMLS/C1553451	denotes	m. PGC
T12216	22650-22655	UMLS/C0443221	denotes	follo
T12217	22758-22763	UMLS/C0443221	denotes	stim
T12218	22920-22925	UMLS/C0443221	denotes	, def
T12219	23076-23081	UMLS/C0443221	denotes	± 1.5
T12220	18966-18973	UMLS/C2350002	denotes	entral
T12221	18394-18398	UMLS/C1704379	denotes	we
T12222	18369-18378	UMLS/C1285572	denotes	type. As
T12223	20949-20958	UMLS/C1285572	denotes	fferences
T12224	21701-21710	UMLS/C1285572	denotes	To this
T12225	21340-21344	UMLS/C1706317	denotes	did
T12226	20873-20880	UMLS/C0542351	denotes	her eva
T12227	19083-19087	UMLS/C1710706	denotes	igni
T12228	21317-21325	UMLS/C0443241	denotes	4A). Si
T12229	21532-21540	UMLS/C0443241	denotes	deficits
T12230	18386-18393	UMLS/C1279901	denotes	al step
T12231	22852-22859	UMLS/C1279901	denotes	1α−/− m
T12232	23068-23075	UMLS/C1279901	denotes	e (14.6
T12233	21007-21012	UMLS/C0037088	denotes	contr
T12234	18650-18658	UMLS/C0243148	denotes	igure 4)
T12235	18820-18828	UMLS/C0243148	denotes	ly, PGC-
T12236	21056-21064	UMLS/C0243148	denotes	on, and
T12237	21363-21371	UMLS/C0243148	denotes	imes it
T12238	22540-22548	UMLS/C0243148	denotes	e respon
T12239	22997-23005	UMLS/C0243148	denotes	of fatig
T12240	23233-23241	UMLS/C0243148	denotes	ructure
T12241	21919-21921	UMLS/C0026402	denotes	-1
T12242	22160-22162	UMLS/C0026402	denotes	ns
T12243	18242-18253	UMLS/C1704258	denotes	mality in m
T12244	23312-23325	UMLS/C1704258	denotes	on of skeleta
T12245	23057-23064	UMLS/C0439165	denotes	C-1α−/−
T12246	21470-21473	UMLS/C0453888	denotes	ver
T12247	18928-18932	UMLS/C1704250	denotes	igni
T12248	21424-21429	UMLS/C1704250	denotes	0° in
T12249	21971-21978	UMLS/C0443318	denotes	86 ± 10
T12250	22650-22655	UMLS/C0563538	denotes	follo
T12251	22758-22763	UMLS/C0563538	denotes	stim
T12252	22920-22925	UMLS/C0563538	denotes	, def
T12253	23076-23081	UMLS/C0563538	denotes	± 1.5
T12254	21848-21857	UMLS/C0243111	denotes	exhibite
T12255	22303-22311	UMLS/C0439209	denotes	irect ca
T12256	22796-22805	UMLS/C0851827	denotes	erence in
T12257	21007-21012	UMLS/C0243095	denotes	contr
T12258	18966-18973	UMLS/C0453933	denotes	entral
T12259	18549-18554	UMLS/C0234886	denotes	numb
T12260	22441-22446	UMLS/C0234886	denotes	(141
T12261	23162-23167	UMLS/C0234886	denotes	her w
T12262	19147-19153	UMLS/C1705428	denotes	ggest
T12263	21395-21401	UMLS/C1705428	denotes	climb
T12264	19147-19153	UMLS/C1705429	denotes	ggest
T12265	21395-21401	UMLS/C1705429	denotes	climb
T12266	18449-18455	UMLS/C0031084	denotes	d usin
T12267	22885-22891	UMLS/C0031084	denotes	. Howe
T12268	22379-22387	UMLS/C2348563	denotes	0.9 ± 2.
T12269	21919-21921	UMLS/C0439231	denotes	-1
T12270	22160-22162	UMLS/C0439231	denotes	ns
T12271	22277-22288	UMLS/C0439242	denotes	running pro
T12272	18513-18517	UMLS/C1706429	denotes	exhi
T12273	22694-22702	UMLS/C1548221	denotes	on mitoc
T12274	22948-22956	UMLS/C1548221	denotes	initial
T12275	18513-18517	UMLS/C1706428	denotes	exhi
T12276	18326-18328	UMLS/C0439224	denotes	f
T12277	18190-18205	UMLS/C1280260	denotes	Skeletal Muscle
T12278	18306-18321	UMLS/C1280260	denotes	tal muscle led
T12279	18353-18368	UMLS/C1280260	denotes	tal muscle phen
T12280	21685-21700	UMLS/C1280260	denotes	PGC-1α−/− mice
T12281	23329-23344	UMLS/C1280260	denotes	scle to physiol
T12282	18606-18610	UMLS/C0439227	denotes	red
T12283	18326-18328	UMLS/C2348614	denotes	f
T12284	22825-22828	UMLS/C1366832	denotes	mu
T12285	21884-21890	UMLS/C1301627	denotes	ty to
T12286	18282-18302	UMLS/C0035245	denotes	ratory function in s
T12287	18650-18658	UMLS/C2587213	denotes	igure 4)
T12288	18820-18828	UMLS/C2587213	denotes	ly, PGC-
T12289	21056-21064	UMLS/C2587213	denotes	on, and
T12290	21363-21371	UMLS/C2587213	denotes	imes it
T12291	22540-22548	UMLS/C2587213	denotes	e respon
T12292	22997-23005	UMLS/C2587213	denotes	of fatig
T12293	23233-23241	UMLS/C2587213	denotes	ructure
T12294	18570-18581	UMLS/C0945826	denotes	s and reari
T12295	22829-22839	UMLS/C1548180	denotes	cles isola
T12296	18555-18559	UMLS/C0444504	denotes	r of
T12297	21774-21778	UMLS/C0323983	denotes	appa
T14484	26724-26729	UMLS/C1706074	denotes	ced c
T14485	26802-26807	UMLS/C1706074	denotes	ke vo
T14486	27016-27021	UMLS/C1706074	denotes	rate
T14487	26724-26729	UMLS/C1706073	denotes	ced c
T14488	26802-26807	UMLS/C1706073	denotes	ke vo
T14489	27016-27021	UMLS/C1706073	denotes	rate
T14490	26704-26711	UMLS/C2346689	denotes	rk was
T14491	26704-26711	UMLS/C1708715	denotes	rk was
T14492	23897-23911	UMLS/C0015260	denotes	g (EST). Given
T14493	23870-23878	UMLS/C0015259	denotes	cardiogr
T14494	23934-23942	UMLS/C0015259	denotes	city of
T14495	24024-24032	UMLS/C0015259	denotes	ere perf
T14496	24273-24282	UMLS/C0015259	denotes	ation of
T14497	24451-24459	UMLS/C0015259	denotes	control
T14498	23780-23788	UMLS/C1882979	denotes	ublished
T14499	24479-24487	UMLS/C1882979	denotes	exhaust
T14500	27131-27139	UMLS/C0871261	denotes	as evalu
T14501	27274-27282	UMLS/C0871261	denotes	e (Figur
T14502	27301-27308	UMLS/C2348205	denotes	Howeve
T14503	24079-24096	UMLS/C2708665	denotes	for run-to-exhaus
T14504	23870-23878	UMLS/C1522704	denotes	cardiogr
T14505	23934-23942	UMLS/C1522704	denotes	city of
T14506	24024-24032	UMLS/C1522704	denotes	ere perf
T14507	24273-24282	UMLS/C1522704	denotes	ation of
T14508	24451-24459	UMLS/C1522704	denotes	control
T14509	23700-23711	UMLS/C0750502	denotes	ifferences
T14510	26996-27007	UMLS/C0750502	denotes	normalities
T14511	26712-26722	UMLS/C0009647	denotes	ue to a re
T14512	24543-24547	UMLS/C2347634	denotes	Ech
T14513	26525-26532	UMLS/C1563350	denotes	nerated
T14514	26604-26608	UMLS/C1563350	denotes	) co
T14515	26760-26764	UMLS/C1563350	denotes	lati
T14516	26365-26372	UMLS/C0445223	denotes	ectly a
T14517	26525-26532	UMLS/C1563351	denotes	nerated
T14518	26604-26608	UMLS/C1563351	denotes	) co
T14519	26760-26764	UMLS/C1563351	denotes	lati
T14520	24033-24040	UMLS/C0947630	denotes	rmed to
T14521	24194-24201	UMLS/C0947630	denotes	gimen w
T14522	24507-24517	UMLS/C0392674	denotes	ce (mean 6
T14523	26317-26327	UMLS/C0392674	denotes	e related
T14524	27436-27455	UMLS/C1997754	denotes	en together with th
T14525	24608-24612	UMLS/C0205091	denotes	ing
T14526	24899-24903	UMLS/C0205091	denotes	as d
T14527	27497-27501	UMLS/C0205091	denotes	the
T14528	27359-27364	UMLS/C0205090	denotes	hear
T14529	26644-26661	UMLS/C0871470	denotes	l loading conditi
T14530	24773-24782	UMLS/C0015272	denotes	g the pos
T14531	27402-27411	UMLS/C0015272	denotes	ation (Fi
T14532	24164-24169	UMLS/C1880279	denotes	ts of
T14533	23460-23466	UMLS/C1547928	denotes	that
T14534	27359-27364	UMLS/C0035621	denotes	hear
T14535	26533-26537	UMLS/C2347637	denotes	lowe
T14536	23534-23538	UMLS/C0182537	denotes	unct
T14537	23585-23594	UMLS/C0024660	denotes	ian organ
T14538	23623-23640	UMLS/C2348164	denotes	ing studies of PG
T14539	23913-23916	UMLS/C0013806	denotes	hat
T14540	24159-24162	UMLS/C0013806	denotes	res
T14541	24206-24209	UMLS/C0013806	denotes	rfo
T14542	26223-26226	UMLS/C0013806	denotes	iac
T14543	27534-27537	UMLS/C0013806	denotes	oun
T14544	23439-23447	UMLS/C0359583	denotes	ed in he
T14545	26328-26334	UMLS/C1314792	denotes	o skel
T14546	23522-23524	UMLS/C0319022	denotes	nt
T14547	23774-23776	UMLS/C0319022	denotes	s
T14548	24056-24058	UMLS/C0319022	denotes	ab
T14549	24119-24121	UMLS/C0319022	denotes	rg
T14550	24306-24308	UMLS/C0319022	denotes	te
T14551	26373-26375	UMLS/C0319022	denotes	se
T14552	26405-26407	UMLS/C0319022	denotes	s
T14553	26672-26674	UMLS/C0319022	denotes	1)
T14554	26773-26775	UMLS/C0319022	denotes	bu
T14555	26870-26872	UMLS/C0319022	denotes	ot
T14556	26991-26993	UMLS/C0319022	denotes	en
T14557	27026-27028	UMLS/C0319022	denotes	ve
T14558	27140-27142	UMLS/C0319022	denotes	te
T14559	27283-27285	UMLS/C0319022	denotes	5
T14560	27456-27458	UMLS/C0319022	denotes	E
T14561	27612-27614	UMLS/C0319022	denotes	im
T14562	27734-27736	UMLS/C0319022	denotes	io
T14563	24980-24983	UMLS/C0005341	denotes	mi
T14564	26979-26982	UMLS/C0005341	denotes	ngu
T14565	26533-26537	UMLS/C1513371	denotes	lowe
T14566	27562-27569	UMLS/C1705535	denotes	opic re
T14567	26816-26824	UMLS/C1546849	denotes	iminishe
T14568	27636-27648	UMLS/C0598012	denotes	renergic inp
T14569	24561-24566	UMLS/C2348147	denotes	-dete
T14570	27624-27635	UMLS/C1548787	denotes	ctivate β-a
T14571	24786-24799	UMLS/C1548788	denotes	ercise period
T14572	24942-24951	UMLS/C0392756	denotes	the PGC-
T14573	26338-26345	UMLS/C0392756	denotes	muscle
T14574	26739-26748	UMLS/C0392756	denotes	put (Tabl
T14575	26778-26785	UMLS/C0392756	denotes	n of he
T14576	26969-26978	UMLS/C0392756	denotes	ther dist
T14577	27692-27699	UMLS/C0234402	denotes	t revea
T14578	26590-26595	UMLS/C1548802	denotes	tolic
T14579	24692-24698	UMLS/C0221193	denotes	he mea
T14580	24833-24839	UMLS/C0221193	denotes	diogra
T14581	26184-26190	UMLS/C0221193	denotes	not d
T14582	26610-26624	UMLS/C0007165	denotes	ared to PGC-1α
T14583	26786-26800	UMLS/C0007165	denotes	rt rate and st
T14584	26884-26898	UMLS/C0007165	denotes	ed, because bo
T14585	27237-27245	UMLS/C0520453	denotes	imilar i
T14586	27008-27014	UMLS/C1561545	denotes	in hea
T14587	26590-26595	UMLS/C1619811	denotes	tolic
T14588	26417-26423	UMLS/C1516048	denotes	/− and
T14589	24033-24040	UMLS/C1880229	denotes	rmed to
T14590	24194-24201	UMLS/C1880229	denotes	gimen w
T14591	23913-23916	UMLS/C1705156	denotes	hat
T14592	24159-24162	UMLS/C1705156	denotes	res
T14593	24206-24209	UMLS/C1705156	denotes	rfo
T14594	26223-26226	UMLS/C1705156	denotes	iac
T14595	27534-27537	UMLS/C1705156	denotes	oun
T14596	27428-27435	UMLS/C1997138	denotes	ph). Ta
T14597	26365-26372	UMLS/C0439849	denotes	ectly a
T14598	26408-26416	UMLS/C1947931	denotes	f PGC-1α
T14599	26590-26595	UMLS/C1708760	denotes	tolic
T14600	23832-23841	UMLS/C1524026	denotes	erve was
T14601	23744-23764	UMLS/C0080309	denotes	unction compared to
T14602	27089-27109	UMLS/C0080309	denotes	-adrenergic-selectiv
T14603	24319-24328	UMLS/C0681842	denotes	or the PG
T14604	27674-27679	UMLS/C1955473	denotes	our r
T14605	24692-24698	UMLS/C0332182	denotes	he mea
T14606	24833-24839	UMLS/C0332182	denotes	diogra
T14607	26184-26190	UMLS/C0332182	denotes	not d
T14608	27131-27139	UMLS/C1704632	denotes	as evalu
T14609	27274-27282	UMLS/C1704632	denotes	e (Figur
T14610	26590-26595	UMLS/C0441994	denotes	tolic
T14611	26328-26334	UMLS/C0678227	denotes	o skel
T14612	23359-23369	UMLS/C2700217	denotes	Functional
T14613	23817-23827	UMLS/C2700217	denotes	d metaboli
T14614	27263-27273	UMLS/C2700217	denotes	C-1α−/− mi
T14615	27674-27679	UMLS/C1556044	denotes	our r
T14616	24667-24676	UMLS/C1704646	denotes	ediately
T14617	23913-23916	UMLS/C1337108	denotes	hat
T14618	24159-24162	UMLS/C1337108	denotes	res
T14619	24206-24209	UMLS/C1337108	denotes	rfo
T14620	26223-26226	UMLS/C1337108	denotes	iac
T14621	27534-27537	UMLS/C1337108	denotes	oun
T14622	24046-24055	UMLS/C1550369	denotes	e a reaso
T14623	24222-24231	UMLS/C1550369	denotes	PGC-1α+/
T14624	24888-24898	UMLS/C0521095	denotes	hortening
T14625	26328-26334	UMLS/C1524003	denotes	o skel
T14626	23919-23924	UMLS/C1947971	denotes	e exe
T14627	24625-24646	UMLS/C2599768	denotes	e were monitored for
T14628	24916-24937	UMLS/C2599768	denotes	he PGC-1α−/− mice, bu
T14629	27461-27472	UMLS/C0001637	denotes	these resu
T14630	27716-27727	UMLS/C0001637	denotes	ntractile d
T14631	23425-23435	UMLS/C0017262	denotes	sion is en
T14632	23573-23577	UMLS/C0376558	denotes	f th
T14633	26712-26722	UMLS/C0348080	denotes	ue to a re
T14634	27605-27611	UMLS/C1299582	denotes	ogic s
T14635	23735-23740	UMLS/C1552077	denotes	ricul
T14636	27436-27455	UMLS/C1997337	denotes	en together with th
T14637	26704-26711	UMLS/C1550025	denotes	rk was
T14638	27473-27484	UMLS/C1292856	denotes	ts strongly
T14639	24164-24169	UMLS/C0178499	denotes	ts of
T14640	24651-24661	UMLS/C0488794	denotes	0-min peri
T14641	26841-26851	UMLS/C0488794	denotes	in the PGC
T14642	27074-27084	UMLS/C0488794	denotes	se to the
T14643	26496-26504	UMLS/C1546680	denotes	olated f
T14644	26546-26554	UMLS/C1546680	denotes	work (c
T14645	24667-24676	UMLS/C0728873	denotes	ediately
T14646	24692-24698	UMLS/C1561960	denotes	he mea
T14647	24833-24839	UMLS/C1561960	denotes	diogra
T14648	26184-26190	UMLS/C1561960	denotes	not d
T14649	24400-24406	UMLS/C1696103	denotes	iately
T14650	24046-24055	UMLS/C0884358	denotes	e a reaso
T14651	24222-24231	UMLS/C0884358	denotes	PGC-1α+/
T14652	24613-24624	UMLS/C1522565	denotes	nd heart ra
T14653	24904-24915	UMLS/C1522565	denotes	creased in
T14654	27251-27262	UMLS/C1522565	denotes	1α+/+ and P
T14655	24033-24040	UMLS/C2349977	denotes	rmed to
T14656	24194-24201	UMLS/C2349977	denotes	gimen w
T14657	23534-23538	UMLS/C1556080	denotes	unct
T14658	24942-24951	UMLS/C0547047	denotes	the PGC-
T14659	26969-26978	UMLS/C0547047	denotes	ther dist
T14660	23780-23788	UMLS/C0009932	denotes	ublished
T14661	24479-24487	UMLS/C0009932	denotes	exhaust
T14662	23387-23393	UMLS/C1281570	denotes	Hearts
T14663	23451-23456	UMLS/C1281570	denotes	a ti
T14664	26446-26452	UMLS/C1281570	denotes	olated
T14665	26539-26545	UMLS/C1281570	denotes	cardia
T14666	27594-27600	UMLS/C1281570	denotes	her ph
T14667	24033-24040	UMLS/C2603343	denotes	rmed to
T14668	24194-24201	UMLS/C2603343	denotes	gimen w
T14669	27516-27524	UMLS/C1883357	denotes	ts are u
T14670	24667-24676	UMLS/C1516647	denotes	ediately
T14671	27473-27484	UMLS/C1948023	denotes	ts strongly
T14672	27114-27118	UMLS/C1515655	denotes	nist
T14673	23992-23998	UMLS/C0205549	denotes	ary tr
T14674	24400-24406	UMLS/C0079595	denotes	iately
T14675	24543-24547	UMLS/C0876919	denotes	Ech
T14676	26704-26711	UMLS/C0403151	denotes	rk was
T14677	23460-23466	UMLS/C0040300	denotes	that
T14678	24421-24432	UMLS/C0205548	denotes	of exercis
T14679	24699-24710	UMLS/C0205548	denotes	heart rate
T14680	23727-23734	UMLS/C0935616	denotes	or ven
T14681	24692-24698	UMLS/C2347804	denotes	he mea
T14682	24833-24839	UMLS/C2347804	denotes	diogra
T14683	26184-26190	UMLS/C2347804	denotes	not d
T14684	26856-26869	UMLS/C0038455	denotes	− mice could
T14685	24667-24676	UMLS/C0181904	denotes	ediately
T14686	24711-24724	UMLS/C1979962	denotes	of the PGC-1α
T14687	24819-24832	UMLS/C1979962	denotes	ition, echoca
T14688	26170-26183	UMLS/C1979962	denotes	of the EST di
T14689	26159-26162	UMLS/C0702093	denotes	he
T14690	26292-26299	UMLS/C1280500	denotes	reduced
T14691	24412-24420	UMLS/C1301820	denotes	wing 60
T14692	23667-23671	UMLS/C0001792	denotes	did
T14693	24366-24370	UMLS/C0001792	denotes	grap
T14694	24692-24698	UMLS/C0439531	denotes	he mea
T14695	24833-24839	UMLS/C0439531	denotes	diogra
T14696	26184-26190	UMLS/C0439531	denotes	not d
T14697	24692-24698	UMLS/C1948053	denotes	he mea
T14698	24833-24839	UMLS/C1948053	denotes	diogra
T14699	26184-26190	UMLS/C1948053	denotes	not d
T14700	24033-24040	UMLS/C0008976	denotes	rmed to
T14701	24194-24201	UMLS/C0008976	denotes	gimen w
T14702	24033-24040	UMLS/C0008972	denotes	rmed to
T14703	24194-24201	UMLS/C0008972	denotes	gimen w
T14704	23370-23383	UMLS/C0000768	denotes	Abnormalities
T14705	26273-26284	UMLS/C0000768	denotes	haustion ca
T14706	27057-27070	UMLS/C0000768	denotes	emodynamic re
T14707	24177-24184	UMLS/C1280519	denotes	tudies,
T14708	26208-26215	UMLS/C1280519	denotes	a prim
T14709	27545-27552	UMLS/C1280519	denotes	ropriat
T14710	23370-23383	UMLS/C0000769	denotes	Abnormalities
T14711	26273-26284	UMLS/C0000769	denotes	haustion ca
T14712	27057-27070	UMLS/C0000769	denotes	emodynamic re
T14713	27705-27713	UMLS/C1879547	denotes	ence for
T14714	27649-27669	UMLS/C2265833	denotes	t to the heart. Howe
T14715	24164-24169	UMLS/C1704464	denotes	ts of
T14716	26525-26532	UMLS/C0043227	denotes	nerated
T14717	26604-26608	UMLS/C0043227	denotes	) co
T14718	26760-26764	UMLS/C0043227	denotes	lati
T14719	23667-23671	UMLS/C0001779	denotes	did
T14720	24366-24370	UMLS/C0001779	denotes	grap
T14721	24667-24676	UMLS/C0596972	denotes	ediately
T14722	26392-26403	UMLS/C0277785	denotes	on, the hea
T14723	26590-26595	UMLS/C1550472	denotes	tolic
T14724	26292-26299	UMLS/C2348382	denotes	reduced
T14725	23667-23671	UMLS/C0001811	denotes	did
T14726	24366-24370	UMLS/C0001811	denotes	grap
T14727	24412-24420	UMLS/C1706701	denotes	wing 60
T14728	23425-23435	UMLS/C0185117	denotes	sion is en
T14729	23735-23740	UMLS/C0456389	denotes	ricul
T14730	24014-24023	UMLS/C0184069	denotes	studies
T14731	23854-23863	UMLS/C0220825	denotes	ng exerci
T14732	27199-27208	UMLS/C0220825	denotes	unctional
T14733	24319-24328	UMLS/C1882327	denotes	or the PG
T14734	26159-26162	UMLS/C1552937	denotes	he
T14735	23504-23521	UMLS/C0014272	denotes	metabolism to ma
T14736	27008-27014	UMLS/C0441889	denotes	in hea
T14737	26533-26537	UMLS/C1705738	denotes	lowe
T14738	26376-26391	UMLS/C1546780	denotes	s cardiac funct
T14739	24800-24807	UMLS/C1511741	denotes	(Figure
T14740	27008-27014	UMLS/C0542560	denotes	in hea
T14741	23809-23816	UMLS/C1522601	denotes	ional a
T14742	26265-26272	UMLS/C1522601	denotes	o the e
T14743	26596-26603	UMLS/C1522601	denotes	pressur
T14744	26752-26759	UMLS/C1522601	denotes	. The r
T14745	24498-24503	UMLS/C1552961	denotes	-1α−/
T14746	23712-23723	UMLS/C1705241	denotes	n chamber s
T14747	26376-26391	UMLS/C0242692	denotes	s cardiac funct
T14748	23943-23951	UMLS/C1516240	denotes	GC-1α−/−
T14749	24543-24547	UMLS/C1704970	denotes	Ech
T14750	23780-23788	UMLS/C1550141	denotes	ublished
T14751	24479-24487	UMLS/C1550141	denotes	exhaust
T14752	23712-23723	UMLS/C1705242	denotes	n chamber s
T14753	23765-23773	UMLS/C1707455	denotes	T contro
T14754	26663-26671	UMLS/C1707455	denotes	s (Table
T14755	26816-26824	UMLS/C0205345	denotes	iminishe
T14756	27510-27515	UMLS/C1883727	denotes	− hea
T14757	26712-26722	UMLS/C1705253	denotes	ue to a re
T14758	27365-27370	UMLS/C0681493	denotes	rate
T14759	27502-27507	UMLS/C0681493	denotes	PGC-1
T14760	23919-23924	UMLS/C1550718	denotes	e exe
T14761	24651-24661	UMLS/C0018810	denotes	0-min peri
T14762	26841-26851	UMLS/C0018810	denotes	in the PGC
T14763	27074-27084	UMLS/C0018810	denotes	se to the
T14764	23667-23671	UMLS/C1114365	denotes	did
T14765	24366-24370	UMLS/C1114365	denotes	grap
T14766	26724-26729	UMLS/C0039224	denotes	ced c
T14767	26802-26807	UMLS/C0039224	denotes	ke vo
T14768	27016-27021	UMLS/C0039224	denotes	rate
T14769	24002-24013	UMLS/C0439611	denotes	ill exercis
T14770	24142-24150	UMLS/C0449238	denotes	ST. Base
T14771	24289-24297	UMLS/C0449238	denotes	match t
T14772	24309-24314	UMLS/C1708943	denotes	aver
T14773	24400-24406	UMLS/C1704382	denotes	iately
T14774	24033-24040	UMLS/C0557651	denotes	rmed to
T14775	24194-24201	UMLS/C0557651	denotes	gimen w
T14776	24561-24566	UMLS/C1514721	denotes	-dete
T14777	24856-24864	UMLS/C1883712	denotes	ed left
T14778	24942-24951	UMLS/C0442797	denotes	the PGC-
T14779	26969-26978	UMLS/C0442797	denotes	ther dist
T14780	26328-26334	UMLS/C0015127	denotes	o skel
T14781	23595-23603	UMLS/C0029235	denotes	sm. Echo
T14782	23539-23547	UMLS/C1705273	denotes	on throu
T14783	23919-23924	UMLS/C1442162	denotes	e exe
T14784	27217-27229	UMLS/C0872350	denotes	to dobutami
T14785	27237-27245	UMLS/C1704454	denotes	imilar i
T14786	26424-26440	UMLS/C0232164	denotes	PGC-1α+/+ mice w
T14787	26376-26391	UMLS/C1550659	denotes	s cardiac funct
T14788	26525-26532	UMLS/C0557351	denotes	nerated
T14789	26604-26608	UMLS/C0557351	denotes	) co
T14790	26760-26764	UMLS/C0557351	denotes	lati
T14791	26496-26504	UMLS/C0205409	denotes	olated f
T14792	26546-26554	UMLS/C0205409	denotes	work (c
T14793	27237-27245	UMLS/C1546572	denotes	imilar i
T14794	24400-24406	UMLS/C1704922	denotes	iately
T14795	27008-27014	UMLS/C0449286	denotes	in hea
T14796	23490-23503	UMLS/C0026237	denotes	ondrial energ
T14797	23387-23393	UMLS/C0018787	denotes	Hearts
T14798	23451-23456	UMLS/C0018787	denotes	a ti
T14799	23809-23816	UMLS/C0018787	denotes	ional a
T14800	26265-26272	UMLS/C0018787	denotes	o the e
T14801	26446-26452	UMLS/C0018787	denotes	olated
T14802	26539-26545	UMLS/C0018787	denotes	cardia
T14803	26596-26603	UMLS/C0018787	denotes	pressur
T14804	26752-26759	UMLS/C0018787	denotes	. The r
T14805	27594-27600	UMLS/C0018787	denotes	her ph
T14806	24309-24314	UMLS/C0336766	denotes	aver
T14807	27365-27370	UMLS/C2698021	denotes	rate
T14808	27502-27507	UMLS/C2698021	denotes	PGC-1
T14809	23842-23849	UMLS/C2347957	denotes	valuate
T14810	24164-24169	UMLS/C1549548	denotes	ts of
T14811	26509-26517	UMLS/C1549542	denotes	GC-1α−/−
T14812	26625-26635	UMLS/C1719797	denotes	/+ mice at
T14813	23780-23788	UMLS/C1547100	denotes	ublished
T14814	24479-24487	UMLS/C1547100	denotes	exhaust
T14815	27510-27515	UMLS/C1515187	denotes	− hea
T14816	24164-24169	UMLS/C1626935	denotes	ts of
T14817	27728-27733	UMLS/C1708517	denotes	sfunc
T14818	24433-24442	UMLS/C1719822	denotes	for the
T14819	25019-25024	UMLS/C0205435	denotes	e 5A)
T14820	23870-23878	UMLS/C0452240	denotes	cardiogr
T14821	23934-23942	UMLS/C0452240	denotes	city of
T14822	24024-24032	UMLS/C0452240	denotes	ere perf
T14823	24273-24282	UMLS/C0452240	denotes	ation of
T14824	24451-24459	UMLS/C0452240	denotes	control
T14825	23490-23503	UMLS/C0521451	denotes	ondrial energ
T14826	26496-26504	UMLS/C0370215	denotes	olated f
T14827	26546-26554	UMLS/C0370215	denotes	work (c
T14828	27359-27364	UMLS/C1552823	denotes	hear
T14829	26926-26931	UMLS/C0006823	denotes	r to
T14830	24608-24612	UMLS/C1552822	denotes	ing
T14831	24899-24903	UMLS/C1552822	denotes	as d
T14832	27497-27501	UMLS/C1552822	denotes	the
T14833	27680-27691	UMLS/C0205463	denotes	sults did n
T14834	24498-24503	UMLS/C1553441	denotes	-1α−/
T14835	23735-23740	UMLS/C1879945	denotes	ricul
T14836	24164-24169	UMLS/C1550601	denotes	ts of
T14837	27131-27139	UMLS/C1706817	denotes	as evalu
T14838	27274-27282	UMLS/C1706817	denotes	e (Figur
T14839	27237-27245	UMLS/C0085590	denotes	imilar i
T14840	26346-26364	UMLS/C0162521	denotes	dysfunction. To di
T14841	24667-24676	UMLS/C0150369	denotes	ediately
T14842	23359-23369	UMLS/C0542341	denotes	Functional
T14843	23539-23547	UMLS/C0542341	denotes	on throu
T14844	23817-23827	UMLS/C0542341	denotes	d metaboli
T14845	27263-27273	UMLS/C0542341	denotes	C-1α−/− mi
T14846	26926-26931	UMLS/C0344312	denotes	r to
T14847	25019-25024	UMLS/C1279901	denotes	e 5A)
T14848	23802-23806	UMLS/C1511726	denotes	c fu
T14849	26257-26264	UMLS/C0439631	denotes	ondary
T14850	24730-24745	UMLS/C1881634	denotes	ce exhibited an
T14851	26346-26364	UMLS/C2709256	denotes	dysfunction. To di
T14852	23780-23788	UMLS/C0243148	denotes	ublished
T14853	24479-24487	UMLS/C0243148	denotes	exhaust
T14854	23678-23680	UMLS/C0026402	denotes	ve
T14855	24377-24379	UMLS/C0026402	denotes	ge
T14856	23370-23383	UMLS/C1704258	denotes	Abnormalities
T14857	26273-26284	UMLS/C1704258	denotes	haustion ca
T14858	27057-27070	UMLS/C1704258	denotes	emodynamic re
T14859	26300-26312	UMLS/C0175668	denotes	exercise tol
T14860	26825-26837	UMLS/C1880177	denotes	cardiac out
T14861	26816-26824	UMLS/C1547039	denotes	iminishe
T14862	24400-24406	UMLS/C1704254	denotes	iately
T14863	23913-23916	UMLS/C0014938	denotes	hat
T14864	24159-24162	UMLS/C0014938	denotes	res
T14865	24206-24209	UMLS/C0014938	denotes	rfo
T14866	26223-26226	UMLS/C0014938	denotes	iac
T14867	27534-27537	UMLS/C0014938	denotes	oun
T14868	23832-23841	UMLS/C0311400	denotes	erve was
T14869	26739-26748	UMLS/C0301630	denotes	put (Tabl
T14870	24033-24040	UMLS/C1705923	denotes	rmed to
T14871	24194-24201	UMLS/C1705923	denotes	gimen w
T14872	23978-23988	UMLS/C0205216	denotes	es of prel
T14873	24942-24951	UMLS/C0205216	denotes	the PGC-
T14874	26873-26883	UMLS/C0205216	denotes	be delinea
T14875	26969-26978	UMLS/C0205216	denotes	ther dist
T14876	27119-27130	UMLS/C0019010	denotes	dobutamine
T14877	24498-24503	UMLS/C2347617	denotes	-1α−/
T14878	23992-23998	UMLS/C2348044	denotes	ary tr
T14879	24079-24096	UMLS/C2709277	denotes	for run-to-exhaus
T14880	26257-26264	UMLS/C0205225	denotes	ondary
T14881	24329-24336	UMLS/C1510992	denotes	-1α−/−
T14882	24164-24169	UMLS/C1705938	denotes	ts of
T14883	27615-27620	UMLS/C1709078	denotes	li th
T14884	23563-23572	UMLS/C0443281	denotes	tal life
T14885	24210-24217	UMLS/C0040808	denotes	med in
T14886	24135-24141	UMLS/C1521840	denotes	r the
T14887	23359-23369	UMLS/C0205245	denotes	Functional
T14888	23817-23827	UMLS/C0205245	denotes	d metaboli
T14889	27263-27273	UMLS/C0205245	denotes	C-1α−/− mi
T14890	24252-24267	UMLS/C1511501	denotes	e exercised for
T14891	23689-23695	UMLS/C0443289	denotes	gnific
T14892	24692-24698	UMLS/C0025344	denotes	he mea
T14893	24833-24839	UMLS/C0025344	denotes	diogra
T14894	26184-26190	UMLS/C0025344	denotes	not d
T14895	26590-26595	UMLS/C0234886	denotes	tolic
T14896	24177-24184	UMLS/C0332294	denotes	tudies,
T14897	26208-26215	UMLS/C0332294	denotes	a prim
T14898	27545-27552	UMLS/C0332294	denotes	ropriat
T14899	24177-24184	UMLS/C1274040	denotes	tudies,
T14900	26208-26215	UMLS/C1274040	denotes	a prim
T14901	27545-27552	UMLS/C1274040	denotes	ropriat
T14902	26816-26824	UMLS/C0080103	denotes	iminishe
T14903	26590-26595	UMLS/C0205251	denotes	tolic
T14904	26590-26595	UMLS/C1611820	denotes	tolic
T14905	23913-23916	UMLS/C0014908	denotes	hat
T14906	24159-24162	UMLS/C0014908	denotes	res
T14907	24206-24209	UMLS/C0014908	denotes	rfo
T14908	26223-26226	UMLS/C0014908	denotes	iac
T14909	27534-27537	UMLS/C0014908	denotes	oun
T14910	23913-23916	UMLS/C1420459	denotes	hat
T14911	24159-24162	UMLS/C1420459	denotes	res
T14912	24206-24209	UMLS/C1420459	denotes	rfo
T14913	26223-26226	UMLS/C1420459	denotes	iac
T14914	27534-27537	UMLS/C1420459	denotes	oun
T14915	24135-24141	UMLS/C0599894	denotes	r the
T14916	24692-24698	UMLS/C0031084	denotes	he mea
T14917	24833-24839	UMLS/C0031084	denotes	diogra
T14918	26184-26190	UMLS/C0031084	denotes	not d
T14919	26639-26652	UMLS/C0442710	denotes	ntical loadin
T14920	23780-23788	UMLS/C0332298	denotes	ublished
T14921	24479-24487	UMLS/C0332298	denotes	exhaust
T14922	24014-24023	UMLS/C2712999	denotes	studies
T14923	26159-26162	UMLS/C0439232	denotes	he
T14924	23678-23680	UMLS/C0439231	denotes	ve
T14925	24377-24379	UMLS/C0439231	denotes	ge
T14926	24059-24065	UMLS/C1704788	denotes	e exer
T14927	26365-26372	UMLS/C1704787	denotes	ectly a
T14928	26704-26711	UMLS/C1704782	denotes	rk was
T14929	24984-24987	UMLS/C1518422	denotes	of
T14930	26932-26935	UMLS/C1518422	denotes	si
T14931	23534-23538	UMLS/C1706421	denotes	unct
T14932	24433-24442	UMLS/C0332282	denotes	for the
T14933	23913-23916	UMLS/C0600510	denotes	hat
T14934	24159-24162	UMLS/C0600510	denotes	res
T14935	24206-24209	UMLS/C0600510	denotes	rfo
T14936	26223-26226	UMLS/C0600510	denotes	iac
T14937	27534-27537	UMLS/C0600510	denotes	oun
T14938	27008-27014	UMLS/C2348088	denotes	in hea
T14939	24433-24442	UMLS/C0332283	denotes	for the
T14940	27461-27472	UMLS/C0599756	denotes	these resu
T14941	27716-27727	UMLS/C0599756	denotes	ntractile d
T14942	26694-26703	UMLS/C0205280	denotes	cardiac w
T14943	24667-24676	UMLS/C1521743	denotes	ediately
T14944	26496-26504	UMLS/C1548221	denotes	olated f
T14945	26546-26554	UMLS/C1548221	denotes	work (c
T14946	27359-27364	UMLS/C0140586	denotes	hear
T14947	26496-26504	UMLS/C1764827	denotes	olated f
T14948	26546-26554	UMLS/C1764827	denotes	work (c
T14949	24177-24184	UMLS/C1546471	denotes	tudies,
T14950	26208-26215	UMLS/C1546471	denotes	a prim
T14951	27545-27552	UMLS/C1546471	denotes	ropriat
T14952	26376-26391	UMLS/C1280260	denotes	s cardiac funct
T14953	26739-26748	UMLS/C0441610	denotes	put (Tabl
T14954	26365-26372	UMLS/C0163712	denotes	ectly a
T14955	23700-23711	UMLS/C1546944	denotes	ifferences
T14956	26996-27007	UMLS/C1546944	denotes	normalities
T14957	27184-27194	UMLS/C0012963	denotes	e ventricu
T14958	27286-27296	UMLS/C0012963	denotes	, right gr
T14959	27176-27183	UMLS/C0243192	denotes	eter. T
T14960	26590-26595	UMLS/C1299352	denotes	tolic
T14961	23525-23533	UMLS/C1314677	denotes	in pump
T14962	26533-26537	UMLS/C2348146	denotes	lowe
T14963	23780-23788	UMLS/C2587213	denotes	ublished
T14964	24479-24487	UMLS/C2587213	denotes	exhaust
T14965	24400-24406	UMLS/C0011923	denotes	iately
T14966	24543-24547	UMLS/C2348143	denotes	Ech
T14967	24543-24547	UMLS/C0444504	denotes	Ech
T14968	23525-23533	UMLS/C0024501	denotes	in pump
T14969	26734-26738	UMLS/C0323983	denotes	c ou
T14970	26392-26403	UMLS/C0031847	denotes	on, the hea
T16852	31596-31603	UMLS/C0221099	denotes	for mit
T16853	28398-28406	UMLS/C1882979	denotes	). Speci
T16854	28600-28608	UMLS/C1882979	denotes	rmogenic
T16855	31039-31046	UMLS/C1882979	denotes	Accordi
T16856	27931-27939	UMLS/C0871261	denotes	nse PGC-
T16857	28159-28167	UMLS/C0871261	denotes	e, PGC-1
T16858	30928-30936	UMLS/C0871261	denotes	rodents
T16859	31137-31145	UMLS/C0871261	denotes	PGC-1α−/
T16860	31391-31399	UMLS/C0871261	denotes	ure 6C).
T16861	31509-31517	UMLS/C0871261	denotes	gic stim
T16862	30174-30181	UMLS/C2348205	denotes	α−/− an
T16863	30334-30341	UMLS/C2348205	denotes	lished
T16864	30626-30633	UMLS/C2348205	denotes	Figure
T16865	28209-28218	UMLS/C2697811	denotes	cold expo
T16866	30576-30581	UMLS/C0205112	denotes	els w
T16867	28636-28645	UMLS/C1314763	denotes	present i
T16868	29988-29997	UMLS/C1314763	denotes	−/− mice.
T16869	28438-28442	UMLS/C2347634	denotes	e te
T16870	28336-28344	UMLS/C0522501	denotes	rop in c
T16871	31065-31081	UMLS/C0597359	denotes	xygen consumptio
T16872	28362-28366	UMLS/C1820374	denotes	mpar
T16873	28454-28458	UMLS/C1820374	denotes	s gr
T16874	30990-30997	UMLS/C0445223	denotes	rol of
T16875	30068-30075	UMLS/C0947630	denotes	icrosco
T16876	27899-27906	UMLS/C0015272	denotes	it an A
T16877	28324-28333	UMLS/C0015272	denotes	y abnorma
T16878	29998-30007	UMLS/C0015272	denotes	Histologi
T16879	28712-29839	UMLS/C0677546	denotes	. Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The
T16880	27910-27918	UMLS/C1550458	denotes	mal Ther
T16881	28345-28353	UMLS/C1550458	denotes	re tempe
T16882	30907-30915	UMLS/C1550458	denotes	ice. The
T16883	30609-30613	UMLS/C0035696	denotes	PGC
T16884	31180-31188	UMLS/C0332128	denotes	(oxygen
T16885	31265-31273	UMLS/C0444706	denotes	4 using
T16886	30155-30169	UMLS/C0041623	denotes	isolated from
T16887	28086-28088	UMLS/C0319022	denotes	er
T16888	28219-28221	UMLS/C0319022	denotes	ur
T16889	28388-28390	UMLS/C0319022	denotes	(F
T16890	28550-28552	UMLS/C0319022	denotes	de
T16891	29956-29958	UMLS/C0319022	denotes	ic
T16892	30471-30473	UMLS/C0319022	denotes	sc
T16893	30530-30532	UMLS/C0319022	denotes	gl
T16894	30900-30902	UMLS/C0319022	denotes	1α
T16895	30998-31000	UMLS/C0319022	denotes	3-
T16896	31146-31148	UMLS/C0319022	denotes	m
T16897	31400-31402	UMLS/C0319022	denotes	Th
T16898	31525-31527	UMLS/C0319022	denotes	is
T16899	31426-31429	UMLS/C0005341	denotes	t t
T16900	30699-30706	UMLS/C1705535	denotes	duction
T16901	28135-28146	UMLS/C1548787	denotes	iate thermo
T16902	30834-30841	UMLS/C0392756	denotes	likely
T16903	31537-31545	UMLS/C0234402	denotes	n the PG
T16904	31403-31406	UMLS/C1412820	denotes	se
T16905	28254-28260	UMLS/C0221193	denotes	ore bo
T16906	30882-30888	UMLS/C0332148	denotes	sponse
T16907	28362-28366	UMLS/C0444669	denotes	mpar
T16908	28454-28458	UMLS/C0444669	denotes	s gr
T16909	29928-29936	UMLS/C1516048	denotes	o charac
T16910	31531-31536	UMLS/C0205178	denotes	ered
T16911	30068-30075	UMLS/C1880229	denotes	icrosco
T16912	31284-31298	UMLS/C0001554	denotes	lorimetry. VO2
T16913	30316-30328	UMLS/C0202236	denotes	o genotypes
T16914	30990-30997	UMLS/C0439849	denotes	rol of
T16915	31499-31508	UMLS/C1524026	denotes	β3-adrene
T16916	30422-30430	UMLS/C1947935	denotes	coupling
T16917	27910-27918	UMLS/C0205161	denotes	mal Ther
T16918	28345-28353	UMLS/C0205161	denotes	re tempe
T16919	30907-30915	UMLS/C0205161	denotes	ice. The
T16920	28077-28080	UMLS/C0006298	denotes	].
T16921	29919-29922	UMLS/C0006298	denotes	al
T16922	30185-30188	UMLS/C0006298	denotes	C-1
T16923	30312-30315	UMLS/C0006298	denotes	e t
T16924	30491-30494	UMLS/C0006298	denotes	o b
T16925	30599-30602	UMLS/C0006298	denotes	-1α
T16926	31521-31524	UMLS/C0006298	denotes	ion
T16927	28209-28218	UMLS/C0681850	denotes	cold expo
T16928	30811-30816	UMLS/C1955473	denotes	chond
T16929	29943-29950	UMLS/C1561569	denotes	the the
T16930	28254-28260	UMLS/C0332182	denotes	ore bo
T16931	28506-28516	UMLS/C2348792	denotes	−/− mice,
T16932	27931-27939	UMLS/C1704632	denotes	nse PGC-
T16933	28159-28167	UMLS/C1704632	denotes	e, PGC-1
T16934	30928-30936	UMLS/C1704632	denotes	rodents
T16935	31137-31145	UMLS/C1704632	denotes	PGC-1α−/
T16936	31391-31399	UMLS/C1704632	denotes	ure 6C).
T16937	31509-31517	UMLS/C1704632	denotes	gic stim
T16938	28077-28080	UMLS/C1412726	denotes	].
T16939	29919-29922	UMLS/C1412726	denotes	al
T16940	30185-30188	UMLS/C1412726	denotes	C-1
T16941	30312-30315	UMLS/C1412726	denotes	e t
T16942	30491-30494	UMLS/C1412726	denotes	o b
T16943	30599-30602	UMLS/C1412726	denotes	-1α
T16944	31521-31524	UMLS/C1412726	denotes	ion
T16945	29951-29955	UMLS/C1705117	denotes	moge
T16946	30414-30421	UMLS/C0033684	denotes	atory u
T16947	30122-30131	UMLS/C1444656	denotes	ltrastruc
T16948	31481-31489	UMLS/C1444656	denotes	ch as co
T16949	28267-28288	UMLS/C0456240	denotes	erature was monitored
T16950	28702-28708	UMLS/C0332197	denotes	shed d
T16951	30502-30520	UMLS/C0040649	denotes	ted by PGC-1α [2].
T16952	30811-30816	UMLS/C1556044	denotes	chond
T16953	28293-28302	UMLS/C1704646	denotes	-1α−/− mi
T16954	28362-28366	UMLS/C1882467	denotes	mpar
T16955	28454-28458	UMLS/C1882467	denotes	s gr
T16956	28089-28098	UMLS/C0521095	denotes	ine wheth
T16957	30081-30090	UMLS/C1550369	denotes	alyses in
T16958	31223-31234	UMLS/C0681814	denotes	administra
T16959	30762-30772	UMLS/C0017262	denotes	other fac
T16960	30422-30430	UMLS/C1314939	denotes	coupling
T16961	28354-28358	UMLS/C2348338	denotes	atur
T16962	28209-28218	UMLS/C1706203	denotes	cold expo
T16963	28354-28358	UMLS/C1705648	denotes	atur
T16964	31164-31175	UMLS/C1292856	denotes	xperiments,
T16965	31581-31592	UMLS/C1292856	denotes	duced capac
T16966	28293-28302	UMLS/C0728873	denotes	-1α−/− mi
T16967	29903-29908	UMLS/C0023779	denotes	ssed
T16968	30047-30052	UMLS/C0023779	denotes	perfo
T16969	30189-30197	UMLS/C1546680	denotes	+/+ mice
T16970	28254-28260	UMLS/C1561960	denotes	ore bo
T16971	30081-30090	UMLS/C0884358	denotes	alyses in
T16972	29943-29950	UMLS/C1555582	denotes	the the
T16973	31531-31536	UMLS/C1547295	denotes	ered
T16974	29903-29908	UMLS/C0023794	denotes	ssed
T16975	30047-30052	UMLS/C0023794	denotes	perfo
T16976	30068-30075	UMLS/C2349977	denotes	icrosco
T16977	28398-28406	UMLS/C0009932	denotes	). Speci
T16978	28600-28608	UMLS/C0009932	denotes	rmogenic
T16979	31039-31046	UMLS/C0009932	denotes	Accordi
T16980	30068-30075	UMLS/C2603343	denotes	icrosco
T16981	29943-29950	UMLS/C1705684	denotes	the the
T16982	29943-29950	UMLS/C1705685	denotes	the the
T16983	28293-28302	UMLS/C1516647	denotes	-1α−/− mi
T16984	31164-31175	UMLS/C1948023	denotes	xperiments,
T16985	31581-31592	UMLS/C1948023	denotes	duced capac
T16986	28367-28378	UMLS/C0039476	denotes	d to the WT
T16987	28459-28470	UMLS/C0039476	denotes	ater than 1
T16988	30249-30254	UMLS/C0687676	denotes	In ad
T16989	31113-31117	UMLS/C1515655	denotes	ulat
T16990	28438-28442	UMLS/C0876919	denotes	e te
T16991	28254-28260	UMLS/C2347804	denotes	ore bo
T16992	28293-28302	UMLS/C0181904	denotes	-1α−/− mi
T16993	31265-31273	UMLS/C0242485	denotes	4 using
T16994	28679-28683	UMLS/C0001792	denotes	in
T16995	28254-28260	UMLS/C0439531	denotes	ore bo
T16996	28254-28260	UMLS/C1948053	denotes	ore bo
T16997	30068-30075	UMLS/C0008976	denotes	icrosco
T16998	30068-30075	UMLS/C0008972	denotes	icrosco
T16999	30691-30698	UMLS/C1280519	denotes	r the i
T17000	31473-31480	UMLS/C1280519	denotes	mulus s
T17001	30536-30545	UMLS/C1879547	denotes	asal and
T17002	29909-29915	UMLS/C1698986	denotes	s an i
T17003	28679-28683	UMLS/C0001779	denotes	in
T17004	28293-28302	UMLS/C0596972	denotes	-1α−/− mi
T17005	30869-30880	UMLS/C1160636	denotes	hermogenic
T17006	31531-31536	UMLS/C1547229	denotes	ered
T17007	28679-28683	UMLS/C0001811	denotes	in
T17008	30762-30772	UMLS/C0185117	denotes	other fac
T17009	30358-30367	UMLS/C0017431	denotes	cold-ind
T17010	28636-28645	UMLS/C0031437	denotes	present i
T17011	29988-29997	UMLS/C0031437	denotes	−/− mice.
T17012	28011-28022	UMLS/C1546767	denotes	atory uncou
T17013	30448-30459	UMLS/C1546767	denotes	in BAT. UCP
T17014	31265-31273	UMLS/C1879489	denotes	4 using
T17015	30302-30308	UMLS/C0441889	denotes	betwee
T17016	30614-30620	UMLS/C0441889	denotes	1α−/−
T17017	28354-28358	UMLS/C1321095	denotes	atur
T17018	31619-31628	UMLS/C0206745	denotes	ratory un
T17019	28443-28450	UMLS/C1511741	denotes	peratur
T17020	30982-30989	UMLS/C0035804	denotes	the con
T17021	28209-28218	UMLS/C1550501	denotes	cold expo
T17022	30842-30850	UMLS/C1516240	denotes	ontribut
T17023	28438-28442	UMLS/C1704970	denotes	e te
T17024	28362-28366	UMLS/C1706352	denotes	mpar
T17025	28454-28458	UMLS/C1706352	denotes	s gr
T17026	28398-28406	UMLS/C1550141	denotes	). Speci
T17027	28600-28608	UMLS/C1550141	denotes	rmogenic
T17028	31039-31046	UMLS/C1550141	denotes	Accordi
T17029	28379-28387	UMLS/C1707455	denotes	controls
T17030	28541-28549	UMLS/C1707455	denotes	ely 3 °C
T17031	30869-30880	UMLS/C0035203	denotes	hermogenic
T17032	31596-31603	UMLS/C0205349	denotes	for mit
T17033	27910-27918	UMLS/C2347472	denotes	mal Ther
T17034	28345-28353	UMLS/C2347472	denotes	re tempe
T17035	30907-30915	UMLS/C2347472	denotes	ice. The
T17036	30483-30487	UMLS/C0018837	denotes	kno
T17037	30302-30308	UMLS/C0456079	denotes	betwee
T17038	30614-30620	UMLS/C0456079	denotes	1α−/−
T17039	28058-28073	UMLS/C0018841	denotes	roduction in BA
T17040	30965-30978	UMLS/C0018841	denotes	oupling is un
T17041	30399-30403	UMLS/C0009264	denotes	hond
T17042	30586-30590	UMLS/C0009264	denotes	imil
T17043	31554-31558	UMLS/C0009264	denotes	mic
T17044	28679-28683	UMLS/C1114365	denotes	in
T17045	31378-31387	UMLS/C0442808	denotes	−/− mice
T17046	30068-30075	UMLS/C0557651	denotes	icrosco
T17047	31378-31387	UMLS/C0442805	denotes	−/− mice
T17048	30292-30300	UMLS/C1883712	denotes	e simila
T17049	27948-27951	UMLS/C2348947	denotes	en
T17050	29959-29971	UMLS/C1880022	denotes	phenotype ex
T17051	31223-31234	UMLS/C1706386	denotes	administra
T17052	28663-28670	UMLS/C0150312	denotes	d, it w
T17053	30189-30197	UMLS/C0205409	denotes	+/+ mice
T17054	30316-30328	UMLS/C0041004	denotes	o genotypes
T17055	31265-31273	UMLS/C0079809	denotes	4 using
T17056	30869-30880	UMLS/C0282636	denotes	hermogenic
T17057	27997-28010	UMLS/C0026237	denotes	ondrial respi
T17058	30141-30154	UMLS/C0026237	denotes	imilar in BAT
T17059	30434-30447	UMLS/C0026237	denotes	generate heat
T17060	30855-30868	UMLS/C0026237	denotes	the abnormal
T17061	31001-31014	UMLS/C0026237	denotes	drenergic rec
T17062	29880-29890	UMLS/C0233426	denotes	stores of
T17063	29951-29955	UMLS/C0454366	denotes	moge
T17064	28398-28406	UMLS/C1547100	denotes	). Speci
T17065	28600-28608	UMLS/C1547100	denotes	rmogenic
T17066	31039-31046	UMLS/C1547100	denotes	Accordi
T17067	31029-31034	UMLS/C0542339	denotes	ignal
T17068	28475-28487	UMLS/C0439093	denotes	at the 5-h t
T17069	31274-31283	UMLS/C1719822	denotes	ndirect c
T17070	30399-30403	UMLS/C0234192	denotes	hond
T17071	30586-30590	UMLS/C0234192	denotes	imil
T17072	31554-31558	UMLS/C0234192	denotes	mic
T17073	27997-28010	UMLS/C0521451	denotes	ondrial respi
T17074	30141-30154	UMLS/C0521451	denotes	imilar in BAT
T17075	30434-30447	UMLS/C0521451	denotes	generate heat
T17076	30855-30868	UMLS/C0521451	denotes	the abnormal
T17077	31001-31014	UMLS/C0521451	denotes	drenergic rec
T17078	30189-30197	UMLS/C0370215	denotes	+/+ mice
T17079	31318-31327	UMLS/C0054075	denotes	ncreased
T17080	31082-31091	UMLS/C0037083	denotes	response
T17081	29869-29879	UMLS/C0205462	denotes	tral lipid
T17082	30032-30042	UMLS/C0205462	denotes	n studies
T17083	30354-30357	UMLS/C0205448	denotes	is
T17084	27931-27939	UMLS/C1706817	denotes	nse PGC-
T17085	28159-28167	UMLS/C1706817	denotes	e, PGC-1
T17086	30928-30936	UMLS/C1706817	denotes	rodents
T17087	31137-31145	UMLS/C1706817	denotes	PGC-1α−/
T17088	31391-31399	UMLS/C1706817	denotes	ure 6C).
T17089	31509-31517	UMLS/C1706817	denotes	gic stim
T17090	29951-29955	UMLS/C1704379	denotes	moge
T17091	30358-30367	UMLS/C1285573	denotes	cold-ind
T17092	28636-28645	UMLS/C1285572	denotes	present i
T17093	29988-29997	UMLS/C1285572	denotes	−/− mice.
T17094	31118-31136	UMLS/C0030055	denotes	on was examined in
T17095	31241-31259	UMLS/C0030055	denotes	the β3-agonist BR
T17096	28209-28218	UMLS/C2349001	denotes	cold expo
T17097	28293-28302	UMLS/C0150369	denotes	-1α−/− mi
T17098	31284-31298	UMLS/C1533734	denotes	lorimetry. VO2
T17099	29943-29950	UMLS/C1279901	denotes	the the
T17100	31334-31354	UMLS/C0006781	denotes	onse to BRL 3744 in
T17101	29858-29862	UMLS/C1511726	denotes	nce
T17102	30282-30286	UMLS/C1511726	denotes	ceri
T17103	30381-30385	UMLS/C1511726	denotes	inv
T17104	28398-28406	UMLS/C0243148	denotes	). Speci
T17105	28600-28608	UMLS/C0243148	denotes	rmogenic
T17106	31039-31046	UMLS/C0243148	denotes	Accordi
T17107	30889-30899	UMLS/C1880177	denotes	in the PGC
T17108	31499-31508	UMLS/C0311400	denotes	β3-adrene
T17109	30068-30075	UMLS/C1705923	denotes	icrosco
T17110	31378-31387	UMLS/C0205217	denotes	−/− mice
T17111	29951-29955	UMLS/C1261552	denotes	moge
T17112	28712-29839	UMLS/C0580836	denotes	. Figure 6 PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response (A) PGC-1α+/+ (n = 15) and PGC-1α−/− (n = 21) mice aged 28–37 d were subjected to cold (4 °C). Core rectal temperature was monitored over a 5-h period. The change in core temperature ± SEM is shown in the graph (left) as a function of time. * p < 0.05. (B) Representative Northern blot analysis (blot and gel at top) performed with RNA isolated from BAT to detect UCP-1 transcript at baseline (RT) and after 5 h of exposure to cold (4 °C) (UCP1). Ethidium bromide (Eth Br) staining of ribosomal RNA is shown as a control. Quantitative real-time RT-PCR for UCP-1 transcript is shown on the graph at the bottom. The values represent mean arbitrary units normalized to a 36B4 transcript (control). (C) Altered response to β3-adrenergic agonist. To evaluate the oxygen consumption (VO2) in response to the stimulation of BAT uncoupled respiration, the β3-adrenergic agonist BRL 37344 was administered to littermate PGC-1α+/+ (n = 5) and PGC-1α−/− (n = 5) female mice followed by measurement of VO2 by indirect calorimetry. Mean ± SEM VO2 is shown. * p < 0.05. The
T17113	30745-30754	UMLS/C1621983	denotes	xposure,
T17114	28663-28670	UMLS/C0449450	denotes	d, it w
T17115	29880-29890	UMLS/C1547010	denotes	stores of
T17116	30113-30121	UMLS/C0936012	denotes	ondrial
T17117	29880-29890	UMLS/C0700364	denotes	stores of
T17118	28254-28260	UMLS/C0025344	denotes	ore bo
T17119	28354-28358	UMLS/C2347093	denotes	atur
T17120	31082-31091	UMLS/C1710082	denotes	response
T17121	30691-30698	UMLS/C0332294	denotes	r the i
T17122	31473-31480	UMLS/C0332294	denotes	mulus s
T17123	30691-30698	UMLS/C1274040	denotes	r the i
T17124	31473-31480	UMLS/C1274040	denotes	mulus s
T17125	28011-28022	UMLS/C0521346	denotes	atory uncou
T17126	30448-30459	UMLS/C0521346	denotes	in BAT. UCP
T17127	30399-30403	UMLS/C0009443	denotes	hond
T17128	30586-30590	UMLS/C0009443	denotes	imil
T17129	31554-31558	UMLS/C0009443	denotes	mic
T17130	27974-27983	UMLS/C0205263	denotes	ble regul
T17131	30404-30413	UMLS/C0205263	denotes	ial respi
T17132	30591-30598	UMLS/C0205263	denotes	r in PG
T17133	30745-30754	UMLS/C0205263	denotes	xposure,
T17134	28254-28260	UMLS/C0031084	denotes	ore bo
T17135	28398-28406	UMLS/C0332298	denotes	). Speci
T17136	28600-28608	UMLS/C0332298	denotes	rmogenic
T17137	31039-31046	UMLS/C0332298	denotes	Accordi
T17138	29943-29950	UMLS/C0205265	denotes	the the
T17139	30990-30997	UMLS/C1704787	denotes	rol of
T17140	28222-28235	UMLS/C0231275	denotes	(4 °C) for a
T17141	30255-30268	UMLS/C0231275	denotes	ition, levels
T17142	30787-30800	UMLS/C0231275	denotes	educed capaci
T17143	30723-30726	UMLS/C1518422	denotes	n o
T17144	31430-31433	UMLS/C1518422	denotes	e m
T17145	31274-31283	UMLS/C0332282	denotes	ndirect c
T17146	31274-31283	UMLS/C0332283	denotes	ndirect c
T17147	28293-28302	UMLS/C1521743	denotes	-1α−/− mi
T17148	30189-30197	UMLS/C1548221	denotes	+/+ mice
T17149	30092-30100	UMLS/C0013850	denotes	cated th
T17150	28362-28366	UMLS/C0008489	denotes	mpar
T17151	28454-28458	UMLS/C0008489	denotes	s gr
T17152	30189-30197	UMLS/C1764827	denotes	+/+ mice
T17153	30092-30100	UMLS/C0013852	denotes	cated th
T17154	30691-30698	UMLS/C1546471	denotes	r the i
T17155	31473-31480	UMLS/C1546471	denotes	mulus s
T17156	29895-29902	UMLS/C1882074	denotes	ere ass
T17157	30101-30112	UMLS/C0205288	denotes	t the mitoc
T17158	30249-30254	UMLS/C0231290	denotes	In ad
T17159	30990-30997	UMLS/C0163712	denotes	rol of
T17160	28354-28358	UMLS/C0991568	denotes	atur
T17161	30524-30529	UMLS/C0205309	denotes	prisi
T17162	28398-28406	UMLS/C2587213	denotes	). Speci
T17163	28600-28608	UMLS/C2587213	denotes	rmogenic
T17164	31039-31046	UMLS/C2587213	denotes	Accordi
T17165	27984-27993	UMLS/C1704735	denotes	tor of mi
T17166	28438-28442	UMLS/C2348143	denotes	e te
T17167	27984-27993	UMLS/C1704734	denotes	tor of mi
T17168	28438-28442	UMLS/C0444504	denotes	e te
T17169	28619-28623	UMLS/C0323983	denotes	was
T17170	30483-30487	UMLS/C0018851	denotes	kno
T17171	28556-28569	UMLS/C0332232	denotes	ent in PGC-1α
T19373	31696-31704	UMLS/C1552607	denotes	ous stud
T19374	35930-35937	UMLS/C0221099	denotes	ared to
T19375	35768-35773	UMLS/C1706074	denotes	dete
T19376	37429-37434	UMLS/C1706074	denotes	ide a
T19377	37660-37665	UMLS/C1706074	denotes	datio
T19378	36161-36170	UMLS/C0035647	denotes	ed hepati
T19379	35768-35773	UMLS/C1706073	denotes	dete
T19380	37429-37434	UMLS/C1706073	denotes	ide a
T19381	37660-37665	UMLS/C1706073	denotes	datio
T19382	32718-32725	UMLS/C1708715	denotes	evealed
T19383	32718-32725	UMLS/C2346689	denotes	evealed
T19384	37622-37629	UMLS/C0549177	denotes	t that,
T19385	32701-32709	UMLS/C1882979	denotes	ing expe
T19386	35993-36001	UMLS/C1882979	denotes	st but s
T19387	38060-38068	UMLS/C1882979	denotes	1α null
T19388	33219-33226	UMLS/C0560184	denotes	elivery
T19389	36148-36156	UMLS/C1551388	denotes	fasting-
T19390	38161-38172	UMLS/C1551388	denotes	atic steato
T19391	32633-32641	UMLS/C0871261	denotes	cytes we
T19392	33219-33226	UMLS/C0560187	denotes	elivery
T19393	31639-31646	UMLS/C0456962	denotes	Fasting
T19394	31935-31939	UMLS/C0456962	denotes	a st
T19395	32599-32606	UMLS/C0456962	denotes	hepatic
T19396	35168-35175	UMLS/C0456962	denotes	epatic
T19397	35749-35755	UMLS/C0456962	denotes	rmed e
T19398	36201-36208	UMLS/C0456962	denotes	or fat
T19399	37294-37301	UMLS/C0456962	denotes	t gene
T19400	37609-37616	UMLS/C0456962	denotes	esults
T19401	37226-37233	UMLS/C2349209	denotes	ally, t
T19402	32106-32112	UMLS/C1551394	denotes	did no
T19403	35470-35473	UMLS/C1272693	denotes	xpr
T19404	35470-35473	UMLS/C1561490	denotes	xpr
T19405	37226-37233	UMLS/C1145667	denotes	ally, t
T19406	31897-31902	UMLS/C0205112	denotes	condi
T19407	32029-32034	UMLS/C0205112	denotes	fed c
T19408	32999-33004	UMLS/C0205112	denotes	xposu
T19409	37736-37746	UMLS/C0729650	denotes	/− mice. T
T19410	36053-36064	UMLS/C0750502	denotes	piration ra
T19411	31867-31876	UMLS/C1314763	denotes	ype was e
T19412	35373-35382	UMLS/C1314763	denotes	d to redu
T19413	32244-32250	UMLS/C0522501	denotes	teatos
T19414	32039-32049	UMLS/C0009647	denotes	ions, the
T19415	35756-35766	UMLS/C0009647	denotes	periments
T19416	38082-38092	UMLS/C0750484	denotes	dentifying
T19417	32711-32717	UMLS/C0133788	denotes	ments
T19418	33042-33048	UMLS/C0133788	denotes	er, th
T19419	35410-35417	UMLS/C0445223	denotes	t genes
T19420	35919-35926	UMLS/C0445223	denotes	ction.
T19422	31705-31712	UMLS/C0947630	denotes	es have
T19423	37044-37051	UMLS/C0947630	denotes	d oxida
T19424	36083-36088	UMLS/C1442792	denotes	ese r
T19425	36095-36100	UMLS/C1442792	denotes	ident
T19426	32125-32132	UMLS/C0015272	denotes	tologic
T19427	32234-32243	UMLS/C0015272	denotes	hepatic
T19428	36030-36039	UMLS/C0015272	denotes	state 2 a
T19429	32106-32112	UMLS/C1550457	denotes	did no
T19430	32643-32654	UMLS/C0227525	denotes	isolated f
T19431	32771-32782	UMLS/C0227525	denotes	utral lipid
T19432	32946-32957	UMLS/C0227525	denotes	/+ hepatocy
T19433	32981-32992	UMLS/C0227525	denotes	ns and foll
T19434	33151-33162	UMLS/C0227525	denotes	ity to main
T19435	35876-35887	UMLS/C0227525	denotes	ed to alter
T19436	36018-36029	UMLS/C0227525	denotes	ion in both
T19437	37929-37940	UMLS/C0227525	denotes	isolated f
T19438	37991-38002	UMLS/C0227525	denotes	Figure 8D),
T19439	38148-38159	UMLS/C0227525	denotes	g-induced h
T19440	37736-37746	UMLS/C1179435	denotes	/− mice. T
T19441	37359-37382	UP/Q95MI7	denotes	mice (Table 2). Furthe
T19442	37302-37310	UMLS/C0086597	denotes	tearoyl-
T19443	37302-37310	UMLS/C0127400	denotes	tearoyl-
T19444	31958-31960	UMLS/C0319022	denotes	uc
T19445	32545-32547	UMLS/C0319022	denotes	ti
T19446	32809-32811	UMLS/C0319022	denotes	e
T19447	32967-32969	UMLS/C0319022	denotes	ba
T19448	33192-33194	UMLS/C0319022	denotes	t
T19449	35338-35340	UMLS/C0319022	denotes	no
T19450	35418-35420	UMLS/C0319022	denotes	T
T19451	35462-35464	UMLS/C0319022	denotes	d
T19452	35809-35811	UMLS/C0319022	denotes	or
T19453	35927-35929	UMLS/C0319022	denotes	om
T19454	35983-35985	UMLS/C0319022	denotes	te
T19455	36957-36959	UMLS/C0319022	denotes	e
T19456	37617-37619	UMLS/C0319022	denotes	ug
T19457	37818-37820	UMLS/C0319022	denotes	i
T19458	38046-38048	UMLS/C0319022	denotes	re
T19459	36049-36052	UMLS/C0005341	denotes	re
T19460	32106-32112	UMLS/C1704701	denotes	did no
T19461	31748-31755	UMLS/C0205054	denotes	c metab
T19462	31859-31866	UMLS/C0205054	denotes	c pheno
T19463	32615-32622	UMLS/C0205054	denotes	c respo
T19464	35204-35211	UMLS/C0205054	denotes	ation e
T19465	35579-35586	UMLS/C0205054	denotes	olved i
T19466	37684-37691	UMLS/C1705535	denotes	e TAG s
T19467	33219-33226	UMLS/C0014653	denotes	elivery
T19468	32438-32444	UMLS/C1609077	denotes	ides o
T19469	35421-35428	UMLS/C0392756	denotes	this e
T19470	35834-35841	UMLS/C0392756	denotes	epatocy
T19471	36065-36074	UMLS/C0392756	denotes	es (Figur
T19472	36236-36243	UMLS/C0392756	denotes	al resp
T19473	31943-31951	UMLS/C0234402	denotes	us known
T19474	32922-32927	UMLS/C1548802	denotes	ytes
T19475	37736-37746	UMLS/C1548799	denotes	/− mice. T
T19476	32922-32927	UMLS/C1619811	denotes	ytes
T19477	32855-32860	UMLS/C1269647	denotes	itate
T19478	31705-31712	UMLS/C1880229	denotes	es have
T19479	37044-37051	UMLS/C1880229	denotes	d oxida
T19480	33030-33041	UMLS/C0332157	denotes	Taken toget
T19481	37484-37511	UP/Q9GMF1	denotes	ep in TAG synthesis, was ac
T19482	32371-32383	UMLS/C0202236	denotes	G) levels (F
T19483	32445-32458	UMLS/C0202236	denotes	free fatty a
T19484	35410-35417	UMLS/C0439849	denotes	t genes
T19485	35919-35926	UMLS/C0439849	denotes	ction.
T19486	37847-37855	UMLS/C1947931	denotes	isolated
T19487	37540-37544	UMLS/C1517741	denotes	ed b
T19488	31756-31765	UMLS/C1524026	denotes	lic funct
T19489	32922-32927	UMLS/C1708760	denotes	ytes
T19490	32583-32591	UMLS/C1947935	denotes	fasting-
T19491	35619-35627	UMLS/C1947935	denotes	on (MCPT
T19492	31655-31672	UMLS/C2711227	denotes	Hepatic Steatosis
T19493	32251-32268	UMLS/C2711227	denotes	s as determined b
T19494	36217-36234	UMLS/C2711227	denotes	due to mitochond
T19495	37226-37233	UMLS/C1167622	denotes	ally, t
T19496	31696-31704	UMLS/C0205156	denotes	ous stud
T19497	38082-38092	UMLS/C1456348	denotes	dentifying
T19498	35675-35679	UMLS/C1413272	denotes	een
T19499	32633-32641	UMLS/C1704632	denotes	cytes we
T19500	32922-32927	UMLS/C0441994	denotes	ytes
T19501	37545-37549	UMLS/C1705117	denotes	fas
T19502	35156-35162	UMLS/C1709305	denotes	gulato
T19503	33099-33107	UMLS/C1444656	denotes	t in PGC
T19504	37269-37274	UMLS/C1317574	denotes	of SR
T19505	36103-36120	UMLS/C0231832	denotes	one potential me
T19506	37359-37382	UP/Q12618	denotes	mice (Table 2). Furthe
T19507	38082-38092	UMLS/C0521093	denotes	dentifying
T19508	37359-37382	UP/O02858	denotes	mice (Table 2). Furthe
T19509	37359-37382	UP/Q7D5W1	denotes	mice (Table 2). Furthe
T19510	32244-32250	UMLS/C1706089	denotes	teatos
T19511	37359-37382	UP/Q9TT94	denotes	mice (Table 2). Furthe
T19512	35550-35559	UMLS/C1550369	denotes	sion of P
T19513	35787-35796	UMLS/C1550369	denotes	the reduc
T19514	32272-32282	UMLS/C0521095	denotes	oss inspec
T19515	35341-35350	UMLS/C0521095	denotes	ype of th
T19516	35812-35821	UMLS/C0521095	denotes	fat oxida
T19517	37906-37916	UMLS/C0521095	denotes	arly 50% i
T19518	37359-37382	UP/Q92038	denotes	mice (Table 2). Furthe
T19519	32726-32737	UMLS/C0681814	denotes	that the PG
T19520	35533-35544	UMLS/C0681814	denotes	he hepatic
T19521	35797-35808	UMLS/C0681814	denotes	d capacity
T19522	32855-32860	UMLS/C1704653	denotes	itate
T19523	35254-35269	UMLS/C0017262	denotes	tivation by PGC
T19524	35429-35439	UMLS/C0017262	denotes	d, a surve
T19525	35587-35597	UMLS/C0017262	denotes	cellular
T19526	37452-37462	UMLS/C0017262	denotes	AT), which
T19527	37359-37382	UP/O94523	denotes	mice (Table 2). Furthe
T19528	37184-37192	UMLS/C1561536	denotes	1c (SREB
T19529	33126-33132	UMLS/C0243067	denotes	that r
T19530	37715-37721	UMLS/C0243067	denotes	ivated
T19531	32583-32591	UMLS/C1314939	denotes	fasting-
T19532	35619-35627	UMLS/C1314939	denotes	on (MCPT
T19533	32039-32049	UMLS/C0348080	denotes	ions, the
T19534	35756-35766	UMLS/C0348080	denotes	periments
T19535	37484-37511	UMLS/C0163260	denotes	ep in TAG synthesis, was ac
T19536	37484-37511	UP/Q8MK44	denotes	ep in TAG synthesis, was ac
T19537	32718-32725	UMLS/C1550025	denotes	evealed
T19538	35177-35181	UMLS/C1418776	denotes	toch
T19539	35443-35447	UMLS/C1418776	denotes	can
T19540	35601-35605	UMLS/C1418776	denotes	y ac
T19541	37484-37511	UP/O74850	denotes	ep in TAG synthesis, was ac
T19542	33255-33263	UMLS/C0011209	denotes	fasting
T19543	32660-32668	UMLS/C1546680	denotes	C-1α−/−
T19544	37920-37928	UMLS/C1546680	denotes	patocyte
T19545	38003-38011	UMLS/C1546680	denotes	confirmi
T19546	32803-32808	UMLS/C0023779	denotes	reate
T19547	33213-33218	UMLS/C0023779	denotes	ased
T19548	35142-35147	UMLS/C0023779	denotes	AR, a
T19549	35675-35679	UMLS/C1412107	denotes	een
T19550	37207-37225	UMLS/C0034987	denotes	ere noted. Specifi
T19551	35550-35559	UMLS/C0884358	denotes	sion of P
T19552	35787-35796	UMLS/C0884358	denotes	the reduc
T19553	31705-31712	UMLS/C2349977	denotes	es have
T19554	37044-37051	UMLS/C2349977	denotes	d oxida
T19555	32803-32808	UMLS/C0023794	denotes	reate
T19556	33213-33218	UMLS/C0023794	denotes	ased
T19557	35142-35147	UMLS/C0023794	denotes	AR, a
T19558	32711-32717	UMLS/C0220884	denotes	ments
T19559	33042-33048	UMLS/C0220884	denotes	er, th
T19560	32701-32709	UMLS/C0009932	denotes	ing expe
T19561	35993-36001	UMLS/C0009932	denotes	st but s
T19562	38060-38068	UMLS/C0009932	denotes	1α null
T19563	31705-31712	UMLS/C2603343	denotes	es have
T19564	37044-37051	UMLS/C2603343	denotes	d oxida
T19565	33068-33076	UMLS/C1883357	denotes	ndicate
T19566	35666-35670	UMLS/C0636220	denotes	rent
T19567	37736-37746	UMLS/C1524073	denotes	/− mice. T
T19568	33057-33059	UMLS/C1424736	denotes	r
T19569	36181-36192	UMLS/C1273518	denotes	: reduced c
T19570	32718-32725	UMLS/C0403151	denotes	evealed
T19571	31639-31646	UMLS/C1550565	denotes	Fasting
T19572	31935-31939	UMLS/C1550565	denotes	a st
T19573	32599-32606	UMLS/C1550565	denotes	hepatic
T19574	35168-35175	UMLS/C1550565	denotes	epatic
T19575	35749-35755	UMLS/C1550565	denotes	rmed e
T19576	36201-36208	UMLS/C1550565	denotes	or fat
T19577	37294-37301	UMLS/C1550565	denotes	t gene
T19578	37609-37616	UMLS/C1550565	denotes	esults
T19579	33204-33212	UMLS/C0178539	denotes	of incr
T19580	35631-35639	UMLS/C0178539	denotes	MCAD) w
T19581	32007-32012	UMLS/C1549480	denotes	in li
T19582	32897-32902	UMLS/C1549480	denotes	ower
T19583	37857-37862	UMLS/C1549480	denotes	epato
T19584	38112-38117	UMLS/C1549480	denotes	mecha
T19585	32349-32361	UMLS/C0242485	denotes	liver trigly
T19586	36148-36156	UMLS/C1550043	denotes	fasting-
T19587	38161-38172	UMLS/C1550043	denotes	atic steato
T19588	31705-31712	UMLS/C0008976	denotes	es have
T19589	37044-37051	UMLS/C0008976	denotes	d oxida
T19590	31705-31712	UMLS/C0008972	denotes	es have
T19591	37044-37051	UMLS/C0008972	denotes	d oxida
T19592	32144-32157	UMLS/C0000768	denotes	es (unpublish
T19593	37067-37080	UMLS/C0000768	denotes	the PGC-1α−/−
T19594	33091-33098	UMLS/C1280519	denotes	us defe
T19595	33168-33175	UMLS/C1280519	denotes	ellular
T19596	36140-36147	UMLS/C1280519	denotes	for the
T19597	37676-37683	UMLS/C1280519	denotes	ts of t
T19598	32144-32157	UMLS/C0000769	denotes	es (unpublish
T19599	37067-37080	UMLS/C0000769	denotes	the PGC-1α−/−
T19600	37572-37581	UMLS/C1879547	denotes	in PGC-1
T19601	37780-37789	UMLS/C1879547	denotes	ly, rates
T19602	37513-37517	UMLS/C1414024	denotes	vate
T19603	37475-37483	UMLS/C1547699	denotes	e last s
T19604	32855-32860	UMLS/C1948049	denotes	itate
T19605	37557-37566	UMLS/C0220781	denotes	a greater
T19606	37758-37767	UMLS/C0220781	denotes	his possi
T19607	38102-38111	UMLS/C0220781	denotes	potential
T19608	36986-36997	UMLS/C0277785	denotes	ling studie
T19609	32438-32444	UMLS/C1546740	denotes	ides o
T19610	32016-32021	UMLS/C0023884	denotes	Unde
T19611	32055-32061	UMLS/C0023884	denotes	of th
T19612	32365-32370	UMLS/C0023884	denotes	de (T
T19613	37012-37017	UMLS/C0023884	denotes	l abn
T19614	32922-32927	UMLS/C1550472	denotes	ytes
T19615	37585-37593	UMLS/C1442488	denotes	mice (T
T19616	35429-35439	UMLS/C0185117	denotes	d, a surve
T19617	35587-35597	UMLS/C0185117	denotes	cellular
T19618	37452-37462	UMLS/C0185117	denotes	AT), which
T19619	32016-32021	UMLS/C0023895	denotes	Unde
T19620	32055-32061	UMLS/C0023895	denotes	of th
T19621	32365-32370	UMLS/C0023895	denotes	de (T
T19622	37012-37017	UMLS/C0023895	denotes	l abn
T19623	32855-32860	UMLS/C1136359	denotes	itate
T19624	32828-32842	UMLS/C1555603	denotes	cells (Figure
T19625	32292-32302	UMLS/C0199219	denotes	red O stai
T19626	32491-32500	UMLS/C0017431	denotes	or faste
T19627	35726-35735	UMLS/C0017431	denotes	able 2).
T19628	31881-31890	UMLS/C0220825	denotes	ted under
T19629	37821-37829	UMLS/C0220825	denotes	to TAG w
T19630	33126-33132	UMLS/C1457869	denotes	that r
T19631	37715-37721	UMLS/C1457869	denotes	ivated
T19632	31867-31876	UMLS/C0031437	denotes	ype was e
T19633	35373-35382	UMLS/C0031437	denotes	d to redu
T19634	37475-37483	UMLS/C2700640	denotes	e last s
T19635	33126-33132	UMLS/C0231172	denotes	that r
T19636	37715-37721	UMLS/C0231172	denotes	ivated
T19637	37200-37206	UMLS/C0038323	denotes	thway
T19638	32556-32567	UMLS/C1292732	denotes	mechanisms
T19639	36974-36985	UMLS/C1546767	denotes	ession prof
T19640	38082-38092	UMLS/C1446409	denotes	dentifying
T19641	32390-32396	UMLS/C0441889	denotes	). The
T19642	37630-37635	UMLS/C0441889	denotes	in ad
T19643	31639-31646	UMLS/C0015663	denotes	Fasting
T19644	31935-31939	UMLS/C0015663	denotes	a st
T19645	32511-32524	UMLS/C0015663	denotes	npublished da
T19646	32599-32606	UMLS/C0015663	denotes	hepatic
T19647	35168-35175	UMLS/C0015663	denotes	epatic
T19648	35749-35755	UMLS/C0015663	denotes	rmed e
T19649	36201-36208	UMLS/C0015663	denotes	or fat
T19650	37294-37301	UMLS/C0015663	denotes	t gene
T19651	37609-37616	UMLS/C0015663	denotes	esults
T19652	32423-32434	UMLS/C1705241	denotes	lasma trigl
T19653	37165-37176	UMLS/C1705241	denotes	nt binding
T19654	35842-35850	UMLS/C1516240	denotes	es of th
T19655	36244-36252	UMLS/C1516240	denotes	ratory d
T19656	32887-32896	UMLS/C0030011	denotes	ficantly
T19657	35859-35868	UMLS/C0030011	denotes	/− mice w
T19658	36261-36952	UMLS/C0030011	denotes	n. Table 2 Metabolic Gene Expression in Liver of Fed and Fasted PGC-1α+/+ and PGC-1α−/− Mice Values represent mean (± SEM) (n ≥ 6 for each group) mRNA levels as determined by real-time RT-PCR corrected for GAPDH signal intensity and normalized (to 1.0) to the value of fed PGC-1α+/+ mice a p < 0.05 versus fed mice of the same genotype b p < 0.05 versus PGC-1α+/+ mice of the same dietary treatment L-CPT I, liver-type carnitine palmitoyltransferase; MCAD, medium-chain acyl-CoA dehydrogenase; SREBP, sterol regulatory element binding protein; SCD, steroyl-CoA desaturase; FAS, fatty acid synthase; GPAT, glycerol-3-phosphate acyltransferase; DGAT, diacylglycerol acyltransferase Althou
T19659	37725-37734	UMLS/C0030011	denotes	the PGC-1
T19660	32423-32434	UMLS/C1705242	denotes	lasma trigl
T19661	35704-35713	UMLS/C1705242	denotes	r fasted
T19662	37165-37176	UMLS/C1705242	denotes	nt binding
T19663	32701-32709	UMLS/C1550141	denotes	ing expe
T19664	35993-36001	UMLS/C1550141	denotes	st but s
T19665	38060-38068	UMLS/C1550141	denotes	1α null
T19666	32958-32966	UMLS/C1707455	denotes	es under
T19667	35974-35982	UMLS/C1707455	denotes	es exhib
T19668	38037-38045	UMLS/C1707455	denotes	s are in
T19669	37736-37746	UMLS/C1705248	denotes	/− mice. T
T19670	35952-35972	UMLS/C0035203	denotes	s, PGC-1α−/− hepatoc
T19671	35930-35937	UMLS/C0205349	denotes	ared to
T19672	35507-35532	UMLS/C1956267	denotes	performed. Surprisingly,
T19673	37018-37043	UMLS/C1956267	denotes	rmalities in the fatty ac
T19674	32390-32396	UMLS/C0456079	denotes	). The
T19675	37630-37635	UMLS/C0456079	denotes	in ad
T19676	32039-32049	UMLS/C1705253	denotes	ions, the
T19677	35756-35766	UMLS/C1705253	denotes	periments
T19678	33062-33067	UMLS/C1883727	denotes	ults
T19679	37359-37382	UP/O62849	denotes	mice (Table 2). Furthe
T19680	32572-32582	UMLS/C1706376	denotes	ved in the
T19681	36171-36180	UMLS/C1706376	denotes	steatosi
T19682	32244-32250	UMLS/C1708936	denotes	teatos
T19683	35768-35773	UMLS/C0039224	denotes	dete
T19684	37429-37434	UMLS/C0039224	denotes	ide a
T19685	37660-37665	UMLS/C0039224	denotes	datio
T19686	32462-32478	UMLS/C0015688	denotes	between the gen
T19687	33245-33254	UMLS/C0442808	denotes	ccurs wit
T19688	37967-37976	UMLS/C0442808	denotes	to PGC-1
T19689	38122-38131	UMLS/C0442808	denotes	contribut
T19690	31705-31712	UMLS/C0557651	denotes	es have
T19691	37044-37051	UMLS/C0557651	denotes	d oxida
T19692	35247-35258	UMLS/C1333402	denotes	or coactiva
T19693	33245-33254	UMLS/C0442805	denotes	ccurs wit
T19694	37967-37976	UMLS/C0442805	denotes	to PGC-1
T19695	38122-38131	UMLS/C0442805	denotes	contribut
T19696	35855-35858	UMLS/C0015677	denotes	-1α
T19697	36257-36260	UMLS/C0015677	denotes	cti
T19698	35778-35782	UMLS/C1883708	denotes	whe
T19699	37622-37629	UMLS/C0205393	denotes	t that,
T19700	31766-31775	UMLS/C1705273	denotes	ons inclu
T19701	32726-32737	UMLS/C1706386	denotes	that the PG
T19702	35533-35544	UMLS/C1706386	denotes	he hepatic
T19703	35797-35808	UMLS/C1706386	denotes	d capacity
T19704	32660-32668	UMLS/C0205409	denotes	C-1α−/−
T19705	37920-37928	UMLS/C0205409	denotes	patocyte
T19706	38003-38011	UMLS/C0205409	denotes	confirmi
T19707	37184-37192	UMLS/C0441655	denotes	1c (SREB
T19708	32106-32112	UMLS/C1873497	denotes	did no
T19709	32371-32383	UMLS/C0041004	denotes	G) levels (F
T19710	32445-32458	UMLS/C0041004	denotes	free fatty a
T19711	37226-37233	UMLS/C1689898	denotes	ally, t
T19712	35212-35225	UMLS/C0026237	denotes	zyme gene exp
T19713	35938-35951	UMLS/C0026237	denotes	the WT contro
T19714	36960-36973	UMLS/C0026237	denotes	iver gene exp
T19715	36148-36156	UMLS/C0205396	denotes	fasting-
T19716	38161-38172	UMLS/C0205396	denotes	atic steato
T19717	31786-31806	UMLS/C1158366	denotes	acid oxidation and g
T19718	31968-31988	UMLS/C1158366	denotes	acid oxidation and g
T19719	35226-35246	UMLS/C1158366	denotes	ession, is a target
T19720	35640-35664	UMLS/C1158366	denotes	re not significantly dif
T19721	37088-37108	UMLS/C1158366	denotes	everal interesting d
T19722	37545-37549	UMLS/C0454366	denotes	fas
T19723	32572-32582	UMLS/C0441712	denotes	ved in the
T19724	36171-36180	UMLS/C0441712	denotes	steatosi
T19725	32701-32709	UMLS/C1547100	denotes	ing expe
T19726	35993-36001	UMLS/C1547100	denotes	st but s
T19727	38060-38068	UMLS/C1547100	denotes	1α null
T19728	33062-33067	UMLS/C1515187	denotes	ults
T19729	33219-33226	UMLS/C0205415	denotes	elivery
T19730	37526-37535	UMLS/C0007382	denotes	line and
T19731	32324-32343	UMLS/C0026019	denotes	opy, and measuremen
T19732	31776-31785	UMLS/C1552866	denotes	ing fatty
T19733	31891-31896	UMLS/C0542339	denotes	basal
T19734	32023-32028	UMLS/C0542339	denotes	basal
T19735	32993-32998	UMLS/C0542339	denotes	wing
T19736	35736-35741	UMLS/C0542339	denotes	ext,
T19737	36083-36088	UMLS/C1301808	denotes	ese r
T19738	36095-36100	UMLS/C1301808	denotes	ident
T19739	36157-36160	UMLS/C0205447	denotes	ndu
T19740	32187-32196	UMLS/C1719822	denotes	24 h-fas
T19741	32438-32444	UMLS/C0032105	denotes	ides o
T19742	35212-35225	UMLS/C0521451	denotes	zyme gene exp
T19743	35938-35951	UMLS/C0521451	denotes	the WT contro
T19744	36960-36973	UMLS/C0521451	denotes	iver gene exp
T19745	35778-35782	UMLS/C1552851	denotes	whe
T19747	37920-37928	UMLS/C0370215	denotes	patocyte
T19748	38003-38011	UMLS/C0370215	denotes	confirmi
T19749	37585-37593	UMLS/C1552824	denotes	mice (T
T19750	33255-33263	UMLS/C1705822	denotes	fasting
T19751	32133-32143	UMLS/C0205462	denotes	abnormalit
T19752	31811-31826	UMLS/C0017715	denotes	eogenesis [18,1
T19753	37545-37549	UMLS/C1704379	denotes	fas
T19754	32491-32500	UMLS/C1285573	denotes	or faste
T19755	35726-35735	UMLS/C1285573	denotes	able 2).
T19756	32633-32641	UMLS/C1706817	denotes	cytes we
T19757	37585-37593	UMLS/C0168634	denotes	mice (T
T19758	31867-31876	UMLS/C1285572	denotes	ype was e
T19759	35373-35382	UMLS/C1285572	denotes	d to redu
T19760	35470-35473	UMLS/C0444930	denotes	xpr
T19761	37246-37254	UMLS/C0537474	denotes	diated d
T19762	37330-37338	UMLS/C0537474	denotes	), was a
T19763	31766-31775	UMLS/C0542341	denotes	ons inclu
T19764	32304-32322	UMLS/C1294000	denotes	ng, electron micro
T19765	32171-32175	UMLS/C1511726	denotes	ver,
T19766	32538-32542	UMLS/C1511726	denotes	r in
T19767	37557-37566	UMLS/C1883254	denotes	a greater
T19768	37758-37767	UMLS/C1883254	denotes	his possi
T19769	38102-38111	UMLS/C1883254	denotes	potential
T19770	35448-35460	UMLS/C1332838	denotes	idate genes
T19771	35487-35502	UMLS/C1332838	denotes	ng experiments
T19772	35606-35618	UMLS/C1332838	denotes	d and oxidat
T19773	37347-37358	UMLS/C1332838	denotes	in PGC-1α−/
T19774	37475-37483	UMLS/C0679058	denotes	e last s
T19775	32701-32709	UMLS/C0243148	denotes	ing expe
T19776	35993-36001	UMLS/C0243148	denotes	st but s
T19777	38060-38068	UMLS/C0243148	denotes	1α null
T19778	37109-37116	UMLS/C1704259	denotes	fferenc
T19779	37256-37263	UMLS/C1704259	denotes	n-regul
T19780	37768-37775	UMLS/C1704259	denotes	ility d
T19781	32144-32157	UMLS/C1704258	denotes	es (unpublish
T19782	37067-37080	UMLS/C1704258	denotes	the PGC-1α−/−
T19783	32007-32012	UMLS/C0871208	denotes	in li
T19784	32897-32902	UMLS/C0871208	denotes	ower
T19785	37857-37862	UMLS/C0871208	denotes	epato
T19786	38112-38117	UMLS/C0871208	denotes	mecha
T19787	37484-37511	UP/O75907	denotes	ep in TAG synthesis, was ac
T19788	37184-37192	UMLS/C0439167	denotes	1c (SREB
T19789	37484-37511	UP/Q9Z2A7	denotes	ep in TAG synthesis, was ac
T19790	32106-32112	UMLS/C0439166	denotes	did no
T19791	37153-37164	UMLS/C0543488	denotes	latory elem
T19792	35477-35483	UMLS/C0038951	denotes	on pro
T19793	31748-31755	UMLS/C0996514	denotes	c metab
T19794	31859-31866	UMLS/C0996514	denotes	c pheno
T19795	32615-32622	UMLS/C0996514	denotes	c respo
T19796	35204-35211	UMLS/C0996514	denotes	ation e
T19797	35579-35586	UMLS/C0996514	denotes	olved i
T19798	31756-31765	UMLS/C0311400	denotes	lic funct
T19799	36065-36074	UMLS/C0301630	denotes	es (Figur
T19800	31705-31712	UMLS/C1705923	denotes	es have
T19801	37044-37051	UMLS/C1705923	denotes	d oxida
T19802	37545-37549	UMLS/C1261552	denotes	fas
T19803	33245-33254	UMLS/C0205217	denotes	ccurs wit
T19804	37967-37976	UMLS/C0205217	denotes	to PGC-1
T19805	38122-38131	UMLS/C0205217	denotes	contribut
T19806	35470-35473	UMLS/C1522314	denotes	xpr
T19807	37622-37629	UMLS/C1704243	denotes	t that,
T19808	35507-35532	UMLS/C0752248	denotes	performed. Surprisingly,
T19809	37018-37043	UMLS/C0752248	denotes	rmalities in the fatty ac
T19810	37484-37511	UP/Q9ERM3	denotes	ep in TAG synthesis, was ac
T19811	32007-32012	UMLS/C1521828	denotes	in li
T19812	32897-32902	UMLS/C1521828	denotes	ower
T19813	37857-37862	UMLS/C1521828	denotes	epato
T19814	38112-38117	UMLS/C1521828	denotes	mecha
T19815	32106-32112	UMLS/C2347086	denotes	did no
T19816	35276-35282	UMLS/C1521840	denotes	]. The
T19817	32304-32322	UMLS/C0069388	denotes	ng, electron micro
T19818	32738-32746	UMLS/C0443289	denotes	-1α−/− h
T19819	37060-37066	UMLS/C0443289	denotes	way in
T19820	37226-37233	UMLS/C0243122	denotes	ally, t
T19821	37878-37891	UMLS/C0243126	denotes	corporation w
T19822	37949-37962	UMLS/C0243126	denotes	α−/− mice com
T19823	32922-32927	UMLS/C0234886	denotes	ytes
T19824	33091-33098	UMLS/C0332294	denotes	us defe
T19825	33168-33175	UMLS/C0332294	denotes	ellular
T19826	36140-36147	UMLS/C0332294	denotes	for the
T19827	37676-37683	UMLS/C0332294	denotes	ts of t
T19828	33091-33098	UMLS/C1274040	denotes	us defe
T19829	33168-33175	UMLS/C1274040	denotes	ellular
T19830	36140-36147	UMLS/C1274040	denotes	for the
T19831	37676-37683	UMLS/C1274040	denotes	ts of t
T19832	37736-37746	UMLS/C0449432	denotes	/− mice. T
T19833	32922-32927	UMLS/C0205251	denotes	ytes
T19834	32922-32927	UMLS/C1611820	denotes	ytes
T19835	37701-37712	UMLS/C0332287	denotes	athway are
T19836	35177-35181	UMLS/C0166418	denotes	toch
T19837	35443-35447	UMLS/C0166418	denotes	can
T19838	35601-35605	UMLS/C0166418	denotes	y ac
T19839	36974-36985	UMLS/C0521346	denotes	ession prof
T19840	31647-31654	UMLS/C0205263	denotes	Induced
T19841	31961-31967	UMLS/C0205263	denotes	fatty
T19842	32607-32614	UMLS/C0205263	denotes	steatot
T19843	36209-36216	UMLS/C0205263	denotes	xidatio
T19844	37598-37605	UMLS/C0205263	denotes	2). The
T19845	31776-31785	UMLS/C2700399	denotes	ing fatty
T19846	35276-35282	UMLS/C0599894	denotes	]. The
T19847	36083-36088	UMLS/C1552743	denotes	ese r
T19848	36095-36100	UMLS/C1552743	denotes	ident
T19849	35507-35532	UMLS/C1449575	denotes	performed. Surprisingly,
T19850	37018-37043	UMLS/C1449575	denotes	rmalities in the fatty ac
T19851	32701-32709	UMLS/C0332298	denotes	ing expe
T19852	35993-36001	UMLS/C0332298	denotes	st but s
T19853	38060-38068	UMLS/C0332298	denotes	1α null
T19854	35410-35417	UMLS/C1704787	denotes	t genes
T19855	35919-35926	UMLS/C1704787	denotes	ction.
T19856	32718-32725	UMLS/C1704782	denotes	evealed
T19857	38143-38147	UMLS/C0456148	denotes	asti
T19858	37311-37326	UMLS/C0013081	denotes	oA desaturase (
T19859	35686-35689	UMLS/C1518422	denotes	oty
T19860	32187-32196	UMLS/C0332282	denotes	24 h-fas
T19861	35778-35782	UMLS/C0332282	denotes	whe
T19862	32855-32860	UMLS/C0007634	denotes	itate
T19863	33204-33212	UMLS/C0007634	denotes	of incr
T19864	35631-35639	UMLS/C0007634	denotes	MCAD) w
T19865	37384-37388	UMLS/C1419846	denotes	ore,
T19866	37109-37116	UMLS/C1705987	denotes	fferenc
T19867	37256-37263	UMLS/C1705987	denotes	n-regul
T19868	37768-37775	UMLS/C1705987	denotes	ility d
T19869	32187-32196	UMLS/C0332283	denotes	24 h-fas
T19870	32660-32668	UMLS/C1548221	denotes	C-1α−/−
T19871	37920-37928	UMLS/C1548221	denotes	patocyte
T19872	38003-38011	UMLS/C1548221	denotes	confirmi
T19873	32660-32668	UMLS/C1764827	denotes	C-1α−/−
T19874	37920-37928	UMLS/C1764827	denotes	patocyte
T19875	38003-38011	UMLS/C1764827	denotes	confirmi
T19876	31776-31785	UMLS/C0332257	denotes	ing fatty
T19877	33091-33098	UMLS/C1546471	denotes	us defe
T19878	33168-33175	UMLS/C1546471	denotes	ellular
T19879	36140-36147	UMLS/C1546471	denotes	for the
T19880	37676-37683	UMLS/C1546471	denotes	ts of t
T19881	32795-32802	UMLS/C1882074	denotes	cantly
T19882	37359-37382	UMLS/C0038233	denotes	mice (Table 2). Furthe
T19883	31903-31927	UMLS/C0231290	denotes	ions and following a 24-
T19884	33005-33029	UMLS/C0231290	denotes	e to oleate (Figure 8B).
T19885	32286-32291	UMLS/C0439806	denotes	, oil
T19886	36065-36074	UMLS/C0441610	denotes	es (Figur
T19887	35410-35417	UMLS/C0163712	denotes	t genes
T19888	35919-35926	UMLS/C0163712	denotes	ction.
T19889	36053-36064	UMLS/C1546944	denotes	piration ra
T19890	32106-32112	UMLS/C0205307	denotes	did no
T19891	31952-31957	UMLS/C0205309	denotes	to in
T19892	35185-35190	UMLS/C0205309	denotes	ial f
T19893	35952-35972	UMLS/C0035245	denotes	s, PGC-1α−/− hepatoc
T19894	37359-37382	UP/Q64420	denotes	mice (Table 2). Furthe
T19895	32922-32927	UMLS/C1299352	denotes	ytes
T19896	33195-33203	UMLS/C1314677	denotes	e contex
T19897	32701-32709	UMLS/C2587213	denotes	ing expe
T19898	35993-36001	UMLS/C2587213	denotes	st but s
T19899	38060-38068	UMLS/C2587213	denotes	1α null
T19900	35191-35200	UMLS/C1704735	denotes	tty acid
T19901	35191-35200	UMLS/C1704734	denotes	tty acid
T19902	37246-37254	UMLS/C1420398	denotes	diated d
T19903	37330-37338	UMLS/C1420398	denotes	), was a
T19904	33195-33203	UMLS/C0024501	denotes	e contex
T19905	36986-36997	UMLS/C0031847	denotes	ling studie
T19906	35465-35469	UMLS/C0323983	denotes	ene
T19907	37830-37834	UMLS/C0323983	denotes	re d
T19908	32016-32021	UMLS/C1278929	denotes	Unde
T19909	32055-32061	UMLS/C1278929	denotes	of th
T19910	32365-32370	UMLS/C1278929	denotes	de (T
T19911	37012-37017	UMLS/C1278929	denotes	l abn
T21822	38576-38583	UP/P67971	denotes	n respo
T21823	38929-38936	UP/P67971	denotes	were f
T21824	39750-39757	UP/P67971	denotes	B). Tak
T21825	38484-38491	UP/P01328	denotes	n-resis
T21826	38576-38583	UP/P01328	denotes	n respo
T21827	38929-38936	UP/P01328	denotes	were f
T21828	39750-39757	UP/P01328	denotes	B). Tak
T21829	38675-38679	UMLS/C0024554	denotes	male
T21830	39383-39391	UMLS/C0871261	denotes	/+ and P
T21831	39514-39522	UMLS/C1272689	denotes	he high-
T21832	39139-39142	UMLS/C0262878	denotes	e =
T21833	39257-39264	UMLS/C2348205	denotes	red to
T21834	39582-39589	UMLS/C2348205	denotes	(Figure
T21835	38188-38192	UMLS/C1563320	denotes	Mild
T21836	38484-38491	UP/P30407	denotes	n-resis
T21837	38576-38583	UP/P30407	denotes	n respo
T21838	38929-38936	UP/P30407	denotes	were f
T21839	39750-39757	UP/P30407	denotes	B). Tak
T21840	38484-38491	UP/P04667	denotes	n-resis
T21841	38576-38583	UP/P04667	denotes	n respo
T21842	38929-38936	UP/P04667	denotes	were f
T21843	39750-39757	UP/P04667	denotes	B). Tak
T21844	38484-38491	UP/P01310	denotes	n-resis
T21845	38576-38583	UP/P01310	denotes	n respo
T21846	38929-38936	UP/P01310	denotes	were f
T21847	39750-39757	UP/P01310	denotes	B). Tak
T21848	38199-38208	UMLS/C1314763	denotes	Phenotype
T21849	38708-38719	UMLS/C0750502	denotes	difference
T21850	39897-39907	UMLS/C0009647	denotes	n resistan
T21851	39103-39107	UMLS/C2347634	denotes	e me
T21852	39133-39137	UMLS/C2347634	denotes	/+ m
T21853	38484-38491	UP/P29335	denotes	n-resis
T21854	38576-38583	UP/P29335	denotes	n respo
T21855	38929-38936	UP/P29335	denotes	were f
T21856	39750-39757	UP/P29335	denotes	B). Tak
T21857	38544-38554	UMLS/C0205100	denotes	eral gluco
T21858	38278-38285	UMLS/C0947630	denotes	es have
T21859	38878-38898	UMLS/C0424619	denotes	tores, glucose toler
T21860	39457-39463	UMLS/C1882509	denotes	for 6
T21861	38244-38251	UMLS/C0015272	denotes	it Insu
T21862	39247-39256	UMLS/C0015272	denotes	ance comp
T21863	39947-39954	UMLS/C0015272	denotes	e gluco
T21864	38484-38491	UP/Q62587	denotes	n-resis
T21865	38576-38583	UP/Q62587	denotes	n respo
T21866	38929-38936	UP/Q62587	denotes	were f
T21868	38834-38839	UMLS/C0677546	denotes	1α−/−
T21869	38604-38612	UMLS/C0332128	denotes	ed in PG
T21870	39352-39359	UMLS/C0332128	denotes	o high-
T21871	38796-38802	UMLS/C1522242	denotes	ed dat
T21872	38983-38988	UMLS/C1522242	denotes	ce te
T21873	39628-39634	UMLS/C1522242	denotes	on a h
T21874	39302-39304	UMLS/C0319022	denotes	e
T21875	39349-39351	UMLS/C0319022	denotes	e
T21876	39392-39394	UMLS/C0319022	denotes	C-
T21877	39777-39779	UMLS/C0319022	denotes	es
T21878	38484-38491	UP/P51463	denotes	n-resis
T21879	38576-38583	UP/P51463	denotes	n respo
T21880	38929-38936	UP/P51463	denotes	were f
T21881	39750-39757	UP/P51463	denotes	B). Tak
T21882	38403-38434	UMLS/C0342335	denotes	n resistance and diabetes [27,3
T21883	38484-38491	UP/P69045	denotes	n-resis
T21884	38576-38583	UP/P69045	denotes	n respo
T21885	38929-38936	UP/P69045	denotes	were f
T21886	39750-39757	UP/P69045	denotes	B). Tak
T21887	38291-38300	UMLS/C1705535	denotes	sted that
T21888	38484-38491	UP/P01340	denotes	n-resis
T21889	38576-38583	UP/P01340	denotes	n respo
T21890	38929-38936	UP/P01340	denotes	were f
T21891	39750-39757	UP/P01340	denotes	B). Tak
T21892	39404-39408	UMLS/C1561465	denotes	wer
T21893	39573-39577	UMLS/C1561465	denotes	− gr
T21894	39700-39704	UMLS/C1561465	denotes	sens
T21895	38484-38491	UP/P01314	denotes	n-resis
T21896	38576-38583	UP/P01314	denotes	n respo
T21897	38929-38936	UP/P01314	denotes	were f
T21898	39750-39757	UP/P01314	denotes	B). Tak
T21899	38484-38491	UP/P68245	denotes	n-resis
T21900	38576-38583	UP/P68245	denotes	n respo
T21901	38929-38936	UP/P68245	denotes	were f
T21902	39750-39757	UP/P68245	denotes	B). Tak
T21903	38484-38491	UP/P12704	denotes	n-resis
T21904	38576-38583	UP/P12704	denotes	n respo
T21905	38929-38936	UP/P12704	denotes	were f
T21906	39750-39757	UP/P12704	denotes	B). Tak
T21907	38484-38491	UP/Q91XI3	denotes	n-resis
T21908	38576-38583	UP/Q91XI3	denotes	n respo
T21909	38929-38936	UP/Q91XI3	denotes	were f
T21910	39750-39757	UP/Q91XI3	denotes	B). Tak
T21911	39144-39150	UMLS/C0944911	denotes	2.4 ±
T21912	38484-38491	UP/P68243	denotes	n-resis
T21913	38576-38583	UP/P68243	denotes	n respo
T21914	38929-38936	UP/P68243	denotes	were f
T21915	39750-39757	UP/P68243	denotes	B). Tak
T21916	38484-38491	UP/P01336	denotes	n-resis
T21917	38576-38583	UP/P01336	denotes	n respo
T21918	38929-38936	UP/P01336	denotes	were f
T21919	39750-39757	UP/P01336	denotes	B). Tak
T21920	38796-38802	UMLS/C1561557	denotes	ed dat
T21921	38983-38988	UMLS/C1561557	denotes	ce te
T21922	39628-39634	UMLS/C1561557	denotes	on a h
T21923	38278-38285	UMLS/C1880229	denotes	es have
T21924	38484-38491	UP/Q8HXV2	denotes	n-resis
T21925	38576-38583	UP/Q8HXV2	denotes	n respo
T21926	38929-38936	UP/Q8HXV2	denotes	were f
T21927	39750-39757	UP/Q8HXV2	denotes	B). Tak
T21928	38484-38491	UP/Q9NDE7	denotes	n-resis
T21929	38576-38583	UP/Q9NDE7	denotes	n respo
T21930	38929-38936	UP/Q9NDE7	denotes	were f
T21931	39750-39757	UP/Q9NDE7	denotes	B). Tak
T21932	39724-39728	UMLS/C0205172	denotes	e PG
T21933	40013-40017	UMLS/C0205172	denotes	t di
T21934	38484-38491	UP/P01324	denotes	n-resis
T21935	38576-38583	UP/P01324	denotes	n respo
T21936	38929-38936	UP/P01324	denotes	were f
T21937	39750-39757	UP/P01324	denotes	B). Tak
T21938	38484-38491	UP/P09476	denotes	n-resis
T21939	38576-38583	UP/P09476	denotes	n respo
T21940	38929-38936	UP/P09476	denotes	were f
T21941	39750-39757	UP/P09476	denotes	B). Tak
T21942	38271-38277	UMLS/C0332185	denotes	t stud
T21943	38193-38198	UMLS/C0028754	denotes	Obese
T21944	39383-39391	UMLS/C1704632	denotes	/+ and P
T21945	39843-39851	UMLS/C1444656	denotes	tions, t
T21946	39080-39101	UMLS/C0043094	denotes	± standard error of
T21947	39543-39556	UMLS/C0043094	denotes	for the PGC-1
T21948	38484-38491	UMLS/C1337112	denotes	n-resis
T21949	38576-38583	UMLS/C1337112	denotes	n respo
T21950	38929-38936	UMLS/C1337112	denotes	were f
T21951	39750-39757	UMLS/C1337112	denotes	B). Tak
T21952	39144-39150	UMLS/C0043100	denotes	2.4 ±
T21953	38823-38828	UMLS/C1947971	denotes	femal
T21954	38637-38662	UMLS/C1260606	denotes	erance testing of 2-mo-ol
T21955	38990-39015	UMLS/C1260606	denotes	ing in 4.5-mo-old female
T21956	38458-38466	UMLS/C1561536	denotes	ty is di
T21957	39897-39907	UMLS/C0348080	denotes	n resistan
T21958	38484-38491	UP/Q6YK33	denotes	n-resis
T21959	38576-38583	UP/Q6YK33	denotes	n respo
T21960	38929-38936	UP/Q6YK33	denotes	were f
T21961	39750-39757	UP/Q6YK33	denotes	B). Tak
T21962	38515-38521	UMLS/C1995013	denotes	[22,2
T21963	39404-39408	UMLS/C1550559	denotes	wer
T21964	39573-39577	UMLS/C1550559	denotes	− gr
T21965	39700-39704	UMLS/C1550559	denotes	sens
T21966	38484-38491	UP/P12703	denotes	n-resis
T21967	38576-38583	UP/P12703	denotes	n respo
T21968	38929-38936	UP/P12703	denotes	were f
T21969	39750-39757	UP/P12703	denotes	B). Tak
T21970	39144-39150	UMLS/C1705104	denotes	2.4 ±
T21971	38484-38491	UP/P17715	denotes	n-resis
T21972	38576-38583	UP/P17715	denotes	n respo
T21973	38929-38936	UP/P17715	denotes	were f
T21974	39750-39757	UP/P17715	denotes	B). Tak
T21975	38484-38491	UP/P01319	denotes	n-resis
T21976	38576-38583	UP/P01319	denotes	n respo
T21977	38929-38936	UP/P01319	denotes	were f
T21978	39750-39757	UP/P01319	denotes	B). Tak
T21979	38484-38491	UP/P01331	denotes	n-resis
T21980	38576-38583	UP/P01331	denotes	n respo
T21981	38929-38936	UP/P01331	denotes	were f
T21982	39750-39757	UP/P01331	denotes	B). Tak
T21983	38278-38285	UMLS/C2349977	denotes	es have
T21984	39404-39408	UMLS/C1549512	denotes	wer
T21985	39573-39577	UMLS/C1549512	denotes	− gr
T21986	39700-39704	UMLS/C1549512	denotes	sens
T21987	38188-38192	UMLS/C0547040	denotes	Mild
T21988	38278-38285	UMLS/C2603343	denotes	es have
T21989	38675-38679	UMLS/C1706180	denotes	male
T21990	39819-39827	UMLS/C1883357	denotes	fat unde
T21991	38796-38802	UMLS/C1552516	denotes	ed dat
T21992	38983-38988	UMLS/C1552516	denotes	ce te
T21993	39628-39634	UMLS/C1552516	denotes	on a h
T21994	38484-38491	UP/P07453	denotes	n-resis
T21995	38576-38583	UP/P07453	denotes	n respo
T21996	38929-38936	UP/P07453	denotes	were f
T21997	39750-39757	UP/P07453	denotes	B). Tak
T21998	39103-39107	UMLS/C0876919	denotes	e me
T21999	39133-39137	UMLS/C0876919	denotes	/+ m
T22000	38484-38491	UP/P01320	denotes	n-resis
T22001	38576-38583	UP/P01320	denotes	n respo
T22002	38929-38936	UP/P01320	denotes	were f
T22003	39750-39757	UP/P01320	denotes	B). Tak
T22004	38388-38399	UMLS/C1527148	denotes	pment of in
T22005	38359-38369	UMLS/C0018591	denotes	ypes may i
T22006	38484-38491	UP/Q9W7R2	denotes	n-resis
T22007	38576-38583	UP/Q9W7R2	denotes	n respo
T22008	38929-38936	UP/Q9W7R2	denotes	were f
T22009	39750-39757	UP/Q9W7R2	denotes	B). Tak
T22010	38675-38679	UMLS/C0325595	denotes	male
T22011	39534-39537	UMLS/C0001792	denotes	si
T22012	38278-38285	UMLS/C0008976	denotes	es have
T22013	38484-38491	UP/P69047	denotes	n-resis
T22014	38576-38583	UP/P69047	denotes	n respo
T22015	38929-38936	UP/P69047	denotes	were f
T22016	39750-39757	UP/P69047	denotes	B). Tak
T22017	38278-38285	UMLS/C0008972	denotes	es have
T22018	38484-38491	UP/P41522	denotes	n-resis
T22019	38576-38583	UP/P41522	denotes	n respo
T22020	38929-38936	UP/P41522	denotes	were f
T22021	39750-39757	UP/P41522	denotes	B). Tak
T22022	38188-38192	UMLS/C1547225	denotes	Mild
T22023	38484-38491	UMLS/C0021641	denotes	n-resis
T22024	38576-38583	UMLS/C0021641	denotes	n respo
T22025	38929-38936	UMLS/C0021641	denotes	were f
T22026	39750-39757	UMLS/C0021641	denotes	B). Tak
T22027	39835-39842	UMLS/C1280519	denotes	rd cond
T22028	38563-38571	UMLS/C1707797	denotes	al and i
T22029	38484-38491	UP/Q98TA8	denotes	n-resis
T22030	38576-38583	UP/Q98TA8	denotes	n respo
T22031	38929-38936	UP/Q98TA8	denotes	were f
T22032	39750-39757	UP/Q98TA8	denotes	B). Tak
T22033	38484-38491	UP/P68992	denotes	n-resis
T22034	38576-38583	UP/P68992	denotes	n respo
T22035	38929-38936	UP/P68992	denotes	were f
T22036	39750-39757	UP/P68992	denotes	B). Tak
T22037	38796-38802	UMLS/C0441833	denotes	ed dat
T22038	38983-38988	UMLS/C0441833	denotes	ce te
T22039	39628-39634	UMLS/C0441833	denotes	on a h
T22040	38899-38905	UMLS/C1698986	denotes	nce an
T22041	39534-39537	UMLS/C0001779	denotes	si
T22042	38252-38270	UMLS/C0021655	denotes	in Resistance Rece
T22043	39955-39973	UMLS/C0021655	denotes	e-tolerant and ins
T22044	38484-38491	UP/P21563	denotes	n-resis
T22045	38576-38583	UP/P21563	denotes	n respo
T22046	38929-38936	UP/P21563	denotes	were f
T22047	39750-39757	UP/P21563	denotes	B). Tak
T22048	38484-38491	UP/P67973	denotes	n-resis
T22049	38576-38583	UP/P67973	denotes	n respo
T22050	38929-38936	UP/P67973	denotes	were f
T22051	39750-39757	UP/P67973	denotes	B). Tak
T22052	38492-38501	UMLS/C1550464	denotes	ant and d
T22053	38675-38679	UMLS/C0086582	denotes	male
T22054	39486-39494	UMLS/C1556156	denotes	age. Th
T22055	38484-38491	UP/P69046	denotes	n-resis
T22056	38576-38583	UP/P69046	denotes	n respo
T22057	38929-38936	UP/P69046	denotes	were f
T22058	39750-39757	UP/P69046	denotes	B). Tak
T22059	38484-38491	UP/P67969	denotes	n-resis
T22060	38576-38583	UP/P67969	denotes	n respo
T22061	38929-38936	UP/P67969	denotes	were f
T22062	39750-39757	UP/P67969	denotes	B). Tak
T22063	38484-38491	UP/P68987	denotes	n-resis
T22064	38576-38583	UP/P68987	denotes	n respo
T22065	38929-38936	UP/P68987	denotes	were f
T22066	39750-39757	UP/P68987	denotes	B). Tak
T22067	39758-39767	UMLS/C1550474	denotes	n togethe
T22068	39534-39537	UMLS/C0001811	denotes	si
T22069	38370-38373	UMLS/C0454788	denotes	flu
T22070	38965-38974	UMLS/C0220825	denotes	p. Glucos
T22071	38199-38208	UMLS/C0031437	denotes	Phenotype
T22072	38484-38491	UP/P01334	denotes	n-resis
T22073	38576-38583	UP/P01334	denotes	n respo
T22074	38929-38936	UP/P01334	denotes	were f
T22075	39750-39757	UP/P01334	denotes	B). Tak
T22076	39265-39271	UMLS/C0441889	denotes	T mice
T22077	39866-39872	UMLS/C1979886	denotes	α−/− m
T22078	39514-39522	UMLS/C0452588	denotes	he high-
T22079	38484-38491	UP/P01315	denotes	n-resis
T22080	38576-38583	UP/P01315	denotes	n respo
T22081	38929-38936	UP/P01315	denotes	were f
T22082	39750-39757	UP/P01315	denotes	B). Tak
T22083	38484-38491	UP/P18109	denotes	n-resis
T22084	38576-38583	UP/P18109	denotes	n respo
T22085	38929-38936	UP/P18109	denotes	were f
T22086	39750-39757	UP/P18109	denotes	B). Tak
T22087	38515-38521	UMLS/C0026845	denotes	[22,2
T22088	39325-39331	UMLS/C0035804	denotes	e home
T22089	38720-38730	UMLS/C1705241	denotes	in blood g
T22090	39103-39107	UMLS/C1704970	denotes	e me
T22091	39133-39137	UMLS/C1704970	denotes	/+ m
T22092	38720-38730	UMLS/C1705242	denotes	in blood g
T22093	39293-39301	UMLS/C1707455	denotes	ow (Figu
T22094	39768-39776	UMLS/C1707455	denotes	, these
T22095	38210-38216	UMLS/C0086287	denotes	Female
T22096	38684-38690	UMLS/C0086287	denotes	revea
T22097	38840-38846	UMLS/C0086287	denotes	mice d
T22098	39030-39036	UMLS/C0086287	denotes	reveal
T22099	39410-39416	UMLS/C0086287	denotes	placed
T22100	39913-39919	UMLS/C0086287	denotes	reover
T22101	39265-39271	UMLS/C0456079	denotes	T mice
T22102	39897-39907	UMLS/C1705253	denotes	n resistan
T22103	39813-39818	UMLS/C1883727	denotes	body
T22104	38907-38924	UMLS/C0178665	denotes	insulin responsiv
T22105	39275-39292	UMLS/C0178665	denotes	standard rodent c
T22106	38823-38828	UMLS/C1550718	denotes	femal
T22107	39534-39537	UMLS/C1114365	denotes	si
T22108	38484-38491	UP/P67972	denotes	n-resis
T22109	38576-38583	UP/P67972	denotes	n respo
T22110	38929-38936	UP/P67972	denotes	were f
T22111	39750-39757	UP/P67972	denotes	B). Tak
T22112	38306-38314	UMLS/C0205369	denotes	fic PGC-
T22113	38555-38562	UMLS/C0017725	denotes	e dispo
T22114	38484-38491	UP/P68988	denotes	n-resis
T22115	38576-38583	UP/P68988	denotes	n respo
T22116	38929-38936	UP/P68988	denotes	were f
T22117	39750-39757	UP/P68988	denotes	B). Tak
T22118	38278-38285	UMLS/C0557651	denotes	es have
T22119	38484-38491	UP/P01318	denotes	n-resis
T22120	38576-38583	UP/P01318	denotes	n respo
T22121	38929-38936	UP/P01318	denotes	were f
T22122	39750-39757	UP/P01318	denotes	B). Tak
T22123	39111-39125	UMLS/C1710181	denotes	SEM) weight of
T22124	39500-39503	UMLS/C0015677	denotes	ht
T22125	38637-38662	UMLS/C0017741	denotes	erance testing of 2-mo-ol
T22126	38990-39015	UMLS/C0017741	denotes	ing in 4.5-mo-old female
T22127	38484-38491	UP/P12708	denotes	n-resis
T22128	38576-38583	UP/P12708	denotes	n respo
T22129	38929-38936	UP/P12708	denotes	were f
T22130	39750-39757	UP/P12708	denotes	B). Tak
T22131	38484-38491	UP/P81881	denotes	n-resis
T22132	38576-38583	UP/P81881	denotes	n respo
T22133	38929-38936	UP/P81881	denotes	were f
T22134	39750-39757	UP/P81881	denotes	B). Tak
T22135	38210-38216	UMLS/C0015780	denotes	Female
T22136	38684-38690	UMLS/C0015780	denotes	revea
T22137	38840-38846	UMLS/C0015780	denotes	mice d
T22138	39030-39036	UMLS/C0015780	denotes	reveal
T22139	39410-39416	UMLS/C0015780	denotes	placed
T22140	39913-39919	UMLS/C0015780	denotes	reover
T22141	39643-39645	UMLS/C1179706	denotes	ie
T22142	38484-38491	UP/P68991	denotes	n-resis
T22143	38576-38583	UP/P68991	denotes	n respo
T22144	38929-38936	UP/P68991	denotes	were f
T22145	39750-39757	UP/P68991	denotes	B). Tak
T22146	38484-38491	UP/P01321	denotes	n-resis
T22147	38576-38583	UP/P01321	denotes	n respo
T22148	38929-38936	UP/P01321	denotes	were f
T22149	39750-39757	UP/P01321	denotes	B). Tak
T22150	38823-38828	UMLS/C1442162	denotes	femal
T22151	38484-38491	UP/Q9TQY7	denotes	n-resis
T22152	38576-38583	UP/Q9TQY7	denotes	n respo
T22153	38929-38936	UP/Q9TQY7	denotes	were f
T22154	39750-39757	UP/Q9TQY7	denotes	B). Tak
T22155	38484-38491	UMLS/C0202098	denotes	n-resis
T22156	38576-38583	UMLS/C0202098	denotes	n respo
T22157	38929-38936	UMLS/C0202098	denotes	were f
T22158	39750-39757	UMLS/C0202098	denotes	B). Tak
T22159	38484-38491	UP/P01342	denotes	n-resis
T22160	38576-38583	UP/P01342	denotes	n respo
T22161	38929-38936	UP/P01342	denotes	were f
T22162	39750-39757	UP/P01342	denotes	B). Tak
T22163	39724-39728	UMLS/C0439064	denotes	e PG
T22164	40013-40017	UMLS/C0439064	denotes	t di
T22165	38484-38491	UP/O73727	denotes	n-resis
T22166	38576-38583	UP/O73727	denotes	n respo
T22167	38929-38936	UP/O73727	denotes	were f
T22168	39750-39757	UP/O73727	denotes	B). Tak
T22169	38458-38466	UMLS/C0441655	denotes	ty is di
T22170	38323-38354	UMLS/C0752046	denotes	nucleotide polymorphisms and h
T22171	39813-39818	UMLS/C1515187	denotes	body
T22172	38484-38491	UP/P01317	denotes	n-resis
T22173	38576-38583	UP/P01317	denotes	n respo
T22174	38929-38936	UP/P01317	denotes	were f
T22175	39750-39757	UP/P01317	denotes	B). Tak
T22176	39882-39887	UMLS/C0542339	denotes	exhi
T22177	39486-39494	UMLS/C1879985	denotes	age. Th
T22178	38796-38802	UMLS/C1257890	denotes	ed dat
T22179	38983-38988	UMLS/C1257890	denotes	ce te
T22180	39628-39634	UMLS/C1257890	denotes	on a h
T22181	38796-38802	UMLS/C1552839	denotes	ed dat
T22182	38983-38988	UMLS/C1552839	denotes	ce te
T22183	39628-39634	UMLS/C1552839	denotes	on a h
T22184	39404-39408	UMLS/C0012155	denotes	wer
T22185	39573-39577	UMLS/C0012155	denotes	− gr
T22186	39700-39704	UMLS/C0012155	denotes	sens
T22187	39514-39522	UMLS/C1552850	denotes	he high-
T22188	39514-39522	UMLS/C0439659	denotes	he high-
T22189	38484-38491	UP/P01316	denotes	n-resis
T22190	38576-38583	UP/P01316	denotes	n respo
T22191	38929-38936	UP/P01316	denotes	were f
T22192	39750-39757	UP/P01316	denotes	B). Tak
T22193	38734-38747	UMLS/C0005802	denotes	se excursion
T22194	39383-39391	UMLS/C1706817	denotes	/+ and P
T22195	38199-38208	UMLS/C1285572	denotes	Phenotype
T22196	38555-38562	UMLS/C0337438	denotes	e dispo
T22197	38484-38491	UP/P30406	denotes	n-resis
T22198	38576-38583	UP/P30406	denotes	n respo
T22199	38929-38936	UP/P30406	denotes	were f
T22200	39750-39757	UP/P30406	denotes	B). Tak
T22201	38484-38491	UP/P01308	denotes	n-resis
T22202	38576-38583	UP/P01308	denotes	n respo
T22203	38929-38936	UP/P01308	denotes	were f
T22204	39750-39757	UP/P01308	denotes	B). Tak
T22205	38484-38491	UP/P01333	denotes	n-resis
T22206	38576-38583	UP/P01333	denotes	n respo
T22207	38929-38936	UP/P01333	denotes	were f
T22208	39750-39757	UP/P01333	denotes	B). Tak
T22209	38484-38491	UP/P01339	denotes	n-resis
T22210	38576-38583	UP/P01339	denotes	n respo
T22211	38929-38936	UP/P01339	denotes	were f
T22212	39750-39757	UP/P01339	denotes	B). Tak
T22213	38484-38491	UP/P09477	denotes	n-resis
T22214	38576-38583	UP/P09477	denotes	n respo
T22215	38929-38936	UP/P09477	denotes	were f
T22216	39750-39757	UP/P09477	denotes	B). Tak
T22217	39873-39881	UMLS/C0344335	denotes	ce do no
T22218	38816-38820	UMLS/C1511726	denotes	old
T22219	38484-38491	UP/P01311	denotes	n-resis
T22220	38576-38583	UP/P01311	denotes	n respo
T22221	38929-38936	UP/P01311	denotes	were f
T22222	39750-39757	UP/P01311	denotes	B). Tak
T22223	38796-38802	UMLS/C0439745	denotes	ed dat
T22224	38983-38988	UMLS/C0439745	denotes	ce te
T22225	39628-39634	UMLS/C0439745	denotes	on a h
T22226	38484-38491	UP/P01335	denotes	n-resis
T22227	38576-38583	UP/P01335	denotes	n respo
T22228	38929-38936	UP/P01335	denotes	were f
T22229	39750-39757	UP/P01335	denotes	B). Tak
T22230	38458-38466	UMLS/C0439167	denotes	ty is di
T22231	39316-39324	UMLS/C1442989	denotes	ne gluco
T22232	39888-39896	UMLS/C1442989	denotes	it insul
T22233	39360-39379	UMLS/C1326961	denotes	at diet, female PGC
T22234	38484-38491	UP/P67974	denotes	n-resis
T22235	38576-38583	UP/P67974	denotes	n respo
T22236	38929-38936	UP/P67974	denotes	were f
T22237	39750-39757	UP/P67974	denotes	B). Tak
T22238	38278-38285	UMLS/C1705923	denotes	es have
T22239	38470-38480	UMLS/C0205216	denotes	shed in in
T22240	38834-38839	UMLS/C0580836	denotes	1α−/−
T22241	38492-38501	UMLS/C0332325	denotes	ant and d
T22242	39758-39767	UMLS/C0332324	denotes	n togethe
T22243	38484-38491	UP/P67970	denotes	n-resis
T22244	38576-38583	UP/P67970	denotes	n respo
T22245	38929-38936	UP/P67970	denotes	were f
T22246	39750-39757	UP/P67970	denotes	B). Tak
T22247	38484-38491	UP/P81025	denotes	n-resis
T22248	38576-38583	UP/P81025	denotes	n respo
T22249	38929-38936	UP/P81025	denotes	were f
T22250	39750-39757	UP/P81025	denotes	B). Tak
T22251	38484-38491	UP/P67968	denotes	n-resis
T22252	38576-38583	UP/P67968	denotes	n respo
T22253	38929-38936	UP/P67968	denotes	were f
T22254	39750-39757	UP/P67968	denotes	B). Tak
T22255	38484-38491	UP/P81423	denotes	n-resis
T22256	38576-38583	UP/P81423	denotes	n respo
T22257	38929-38936	UP/P81423	denotes	were f
T22258	39750-39757	UP/P81423	denotes	B). Tak
T22259	38696-38704	UMLS/C0443289	denotes	signifi
T22260	39057-39065	UMLS/C0443289	denotes	eased bo
T22261	39316-39324	UMLS/C0038137	denotes	ne gluco
T22262	39888-39896	UMLS/C0038137	denotes	it insul
T22263	38484-38491	UP/P12705	denotes	n-resis
T22264	38576-38583	UP/P12705	denotes	n respo
T22265	38929-38936	UP/P12705	denotes	were f
T22266	39750-39757	UP/P12705	denotes	B). Tak
T22267	38484-38491	UP/P06306	denotes	n-resis
T22268	38576-38583	UP/P06306	denotes	n respo
T22269	38929-38936	UP/P06306	denotes	were f
T22270	39750-39757	UP/P06306	denotes	B). Tak
T22271	38484-38491	UP/P13190	denotes	n-resis
T22272	38576-38583	UP/P13190	denotes	n respo
T22273	38929-38936	UP/P13190	denotes	were f
T22274	39750-39757	UP/P13190	denotes	B). Tak
T22275	39835-39842	UMLS/C1274040	denotes	rd cond
T22276	39835-39842	UMLS/C0332294	denotes	rd cond
T22277	38484-38491	UP/P68989	denotes	n-resis
T22278	38576-38583	UP/P68989	denotes	n respo
T22279	38929-38936	UP/P68989	denotes	were f
T22280	39750-39757	UP/P68989	denotes	B). Tak
T22281	38796-38802	UMLS/C1705428	denotes	ed dat
T22282	38983-38988	UMLS/C1705428	denotes	ce te
T22283	39628-39634	UMLS/C1705428	denotes	on a h
T22284	38796-38802	UMLS/C1705429	denotes	ed dat
T22285	38983-38988	UMLS/C1705429	denotes	ce te
T22286	39628-39634	UMLS/C1705429	denotes	on a h
T22287	38484-38491	UP/P01329	denotes	n-resis
T22288	38576-38583	UP/P01329	denotes	n respo
T22289	38929-38936	UP/P01329	denotes	were f
T22290	39750-39757	UP/P01329	denotes	B). Tak
T22291	38484-38491	UP/P69048	denotes	n-resis
T22292	38576-38583	UP/P69048	denotes	n respo
T22293	38929-38936	UP/P69048	denotes	were f
T22294	39750-39757	UP/P69048	denotes	B). Tak
T22295	39643-39645	UMLS/C1419033	denotes	ie
T22296	38484-38491	UP/P01330	denotes	n-resis
T22297	38576-38583	UP/P01330	denotes	n respo
T22298	38929-38936	UP/P01330	denotes	were f
T22299	39750-39757	UP/P01330	denotes	B). Tak
T22300	38306-38314	UMLS/C1552740	denotes	fic PGC-
T22301	38484-38491	UMLS/C1145751	denotes	n-resis
T22302	38576-38583	UMLS/C1145751	denotes	n respo
T22303	38929-38936	UMLS/C1145751	denotes	were f
T22304	39750-39757	UMLS/C1145751	denotes	B). Tak
T22305	39511-39513	UMLS/C0439230	denotes	n
T22306	39528-39530	UMLS/C0439230	denotes	et
T22307	38484-38491	UP/P01313	denotes	n-resis
T22308	38576-38583	UP/P01313	denotes	n respo
T22309	38929-38936	UP/P01313	denotes	were f
T22310	39750-39757	UP/P01313	denotes	B). Tak
T22311	38484-38491	UP/P30410	denotes	n-resis
T22312	38576-38583	UP/P30410	denotes	n respo
T22313	38929-38936	UP/P30410	denotes	were f
T22314	39750-39757	UP/P30410	denotes	B). Tak
T22315	38675-38679	UMLS/C1706429	denotes	male
T22316	38675-38679	UMLS/C1706428	denotes	male
T22317	39457-39463	UMLS/C1704765	denotes	for 6
T22318	39835-39842	UMLS/C1546471	denotes	rd cond
T22319	38555-38562	UMLS/C0202042	denotes	e dispo
T22320	38484-38491	UP/P0C236	denotes	n-resis
T22321	38576-38583	UP/P0C236	denotes	n respo
T22322	38929-38936	UP/P0C236	denotes	were f
T22323	39750-39757	UP/P0C236	denotes	B). Tak
T22324	38370-38373	UMLS/C0337876	denotes	flu
T22325	38484-38491	UMLS/C1533581	denotes	n-resis
T22326	38576-38583	UMLS/C1533581	denotes	n respo
T22327	38929-38936	UMLS/C1533581	denotes	were f
T22328	39750-39757	UMLS/C1533581	denotes	B). Tak
T22329	39316-39324	UMLS/C1548173	denotes	ne gluco
T22330	39888-39896	UMLS/C1548173	denotes	it insul
T22331	38484-38491	UP/P42633	denotes	n-resis
T22332	38576-38583	UP/P42633	denotes	n respo
T22333	38929-38936	UP/P42633	denotes	were f
T22334	39750-39757	UP/P42633	denotes	B). Tak
T22335	38708-38719	UMLS/C1546944	denotes	difference
T22336	38484-38491	UMLS/C1579433	denotes	n-resis
T22337	38576-38583	UMLS/C1579433	denotes	n respo
T22338	38929-38936	UMLS/C1579433	denotes	were f
T22339	39750-39757	UMLS/C1579433	denotes	B). Tak
T22340	38210-38216	UMLS/C1705497	denotes	Female
T22341	38684-38690	UMLS/C1705497	denotes	revea
T22342	38840-38846	UMLS/C1705497	denotes	mice d
T22343	39030-39036	UMLS/C1705497	denotes	reveal
T22344	39410-39416	UMLS/C1705497	denotes	placed
T22345	39913-39919	UMLS/C1705497	denotes	reover
T22346	38484-38491	UP/P01327	denotes	n-resis
T22347	38576-38583	UP/P01327	denotes	n respo
T22348	38929-38936	UP/P01327	denotes	were f
T22349	39750-39757	UP/P01327	denotes	B). Tak
T22350	38210-38216	UMLS/C1705498	denotes	Female
T22351	38684-38690	UMLS/C1705498	denotes	revea
T22352	38840-38846	UMLS/C1705498	denotes	mice d
T22353	39030-39036	UMLS/C1705498	denotes	reveal
T22354	39410-39416	UMLS/C1705498	denotes	placed
T22355	39913-39919	UMLS/C1705498	denotes	reover
T22356	39103-39107	UMLS/C2348143	denotes	e me
T22357	39133-39137	UMLS/C2348143	denotes	/+ m
T22358	39139-39142	UMLS/C0432222	denotes	e =
T22359	39316-39324	UMLS/C0175675	denotes	ne gluco
T22360	39888-39896	UMLS/C0175675	denotes	it insul
T22361	39103-39107	UMLS/C0444504	denotes	e me
T22362	39133-39137	UMLS/C0444504	denotes	/+ m
T22363	38484-38491	UP/P68990	denotes	n-resis
T22364	38576-38583	UP/P68990	denotes	n respo
T22365	38929-38936	UP/P68990	denotes	were f
T22366	39750-39757	UP/P68990	denotes	B). Tak
T22367	38978-38982	UMLS/C0323983	denotes	lera
T23683	41553-41562	UMLS/C1709694	denotes	cerebral
T23684	41975-41984	UMLS/C1709694	denotes	microvacu
T23685	41080-41088	UMLS/C1552923	denotes	parieta
T23686	41553-41562	UMLS/C1551390	denotes	cerebral
T23687	41975-41984	UMLS/C1551390	denotes	microvacu
T23688	41080-41088	UMLS/C1552924	denotes	parieta
T23689	40887-40892	UMLS/C0336769	denotes	oscop
T23690	41934-41940	UMLS/C0001128	denotes	c proc
T23691	43202-43211	UMLS/C1272684	denotes	he neurop
T23692	42133-42143	UMLS/C1551388	denotes	cortex. Ne
T23693	43243-43251	UMLS/C1705248	denotes	, presyn
T23694	41904-41913	UMLS/C0522510	denotes	otein-imm
T23695	42887-42890	UMLS/C0445625	denotes	pa
T23697	41468-41499	UP/Q58EE9	denotes	in, failed to show an increase
T23698	42078-42082	UMLS/C0522498	denotes	ll n
T23699	41034-41043	UMLS/C0750484	denotes	asurement
T23700	42967-42976	UMLS/C0750484	denotes	neuropil
T23701	42054-42063	UMLS/C1306665	denotes	Purkinje
T23702	41519-41527	UMLS/C0442808	denotes	ytic pro
T23703	41877-41885	UMLS/C0442808	denotes	glial f
T23704	41519-41527	UMLS/C0442805	denotes	ytic pro
T23705	41877-41885	UMLS/C0442805	denotes	glial f
T23706	40798-40805	UMLS/C1547928	denotes	es of t
T23707	43281-43297	UMLS/C0031307	denotes	ing the soma, or
T23708	43311-43326	UMLS/C0027747	denotes	perikaryal depo
T23709	43089-43097	UMLS/C0520510	denotes	Subcell
T23710	43269-43277	UMLS/C0520510	denotes	als comp
T23711	40866-40871	UMLS/C0006104	denotes	obse
T23712	43044-43052	UMLS/C0042219	denotes	were pre
T23713	43176-43184	UMLS/C0042219	denotes	t vacuol
T23715	41553-41562	UMLS/C1522240	denotes	cerebral
T23716	41975-41984	UMLS/C1522240	denotes	microvacu
T23717	41508-41510	UMLS/C0319022	denotes	s
T23718	41685-41687	UMLS/C0319022	denotes	al
T23719	43199-43201	UMLS/C0319022	denotes	f
T23720	42045-42053	UMLS/C0439064	denotes	acuolate
T23721	41382-41385	UMLS/C0005341	denotes	Fig
T23722	42981-42989	UMLS/C0150312	denotes	re 10B).
T23723	43103-43110	UMLS/C0150312	denotes	ocaliza
T23724	41080-41088	UMLS/C1705191	denotes	parieta
T23725	40703-40713	UMLS/C0678594	denotes	Structural
T23726	40834-40844	UMLS/C0678594	denotes	abnormali
T23727	40935-40947	UMLS/C0440746	denotes	mples demons
T23728	41893-41899	UMLS/C0449788	denotes	y acid
T23729	40866-40871	UMLS/C1269537	denotes	obse
T23730	41468-41499	UP/Q5RA72	denotes	in, failed to show an increase
T23731	42204-42217	UMLS/C0334094	denotes	nflammatory i
T23732	42054-42063	UMLS/C0006121	denotes	Purkinje
T23733	41797-41810	UMLS/C0004781	denotes	also noted i
T23734	43156-43168	UMLS/C1744691	denotes	h; some may
T23735	43116-43122	UMLS/C1515021	denotes	f the
T23736	41697-41703	UMLS/C0449286	denotes	icrova
T23737	41627-41638	UMLS/C0949582	denotes	icrovacuola
T23738	40735-40757	UMLS/C1269563	denotes	Central Nervous System
T23739	42133-42143	UMLS/C0205396	denotes	cortex. Ne
T23740	40866-40871	UMLS/C0006111	denotes	obse
T23741	41096-41109	UMLS/C1268979	denotes	PGC-1α+/+, 1,
T23742	41468-41499	UMLS/C1325793	denotes	in, failed to show an increase
T23743	41697-41703	UMLS/C1561545	denotes	icrova
T23744	41080-41088	UMLS/C1552858	denotes	parieta
T23745	40887-40892	UMLS/C0023700	denotes	oscop
T23746	40887-40892	UMLS/C0023693	denotes	oscop
T23747	40877-40885	UMLS/C1441672	denotes	Light mi
T23748	41213-41219	UMLS/C0205413	denotes	cuolat
T23749	41870-41876	UMLS/C0205413	denotes	sity o
T23750	41893-41899	UMLS/C1554106	denotes	y acid
T23751	40735-40757	UMLS/C0927232	denotes	Central Nervous System
T23752	42887-42890	UMLS/C0927232	denotes	pa
T23753	43064-43074	UMLS/C0205418	denotes	bset of co
T23754	40893-40916	UMLS/C0026018	denotes	c examination of PGC-1α
T23755	41851-41862	UMLS/C0439849	denotes	he number a
T23756	42073-42077	UMLS/C0205171	denotes	le c
T23757	41246-41255	UMLS/C1947935	denotes	and indiv
T23758	42036-42044	UMLS/C1947935	denotes	ly rare
T23759	41468-41499	UMLS/C0017626	denotes	in, failed to show an increase
T23760	41080-41088	UMLS/C0205155	denotes	parieta
T23761	41034-41043	UMLS/C1456348	denotes	asurement
T23762	42967-42976	UMLS/C1456348	denotes	neuropil
T23763	41851-41862	UMLS/C0596306	denotes	he number a
T23764	42078-42082	UMLS/C0521114	denotes	ll n
T23765	42887-42890	UMLS/C0028654	denotes	pa
T23766	42107-42119	UMLS/C0596630	denotes	the PGC-1α−
T23767	42064-42071	UMLS/C0205147	denotes	and gra
T23768	41349-41354	UMLS/C1317574	denotes	mice
T23769	41842-41847	UMLS/C1317574	denotes	ease
T23770	42859-42864	UMLS/C1317574	denotes	exami
T23771	41220-41225	UMLS/C0205146	denotes	on in
T23772	42005-42010	UMLS/C0205146	denotes	mult
T23773	43202-43211	UMLS/C0443211	denotes	he neurop
T23774	40995-41003	UMLS/C0001613	denotes	al compl
T23775	43126-43134	UMLS/C0001613	denotes	oles was
T23776	40887-40892	UMLS/C1881376	denotes	oscop
T23777	41893-41899	UMLS/C1709287	denotes	y acid
T23778	41080-41088	UMLS/C1522472	denotes	parieta
T23779	41034-41043	UMLS/C0521093	denotes	asurement
T23780	42967-42976	UMLS/C0521093	denotes	neuropil
T23781	40941-40955	UMLS/C1292533	denotes	demonstrated a
T23782	41260-41268	UMLS/C0228081	denotes	pyramid
T23783	41754-41762	UMLS/C0228081	denotes	−/− basa
T23784	43021-43029	UMLS/C0228081	denotes	of membr
T23785	43259-43267	UMLS/C0228081	denotes	rve term
T23786	41143-41146	UMLS/C0456786	denotes	−/−
T23787	41190-41193	UMLS/C0456786	denotes	Pat
T23788	42942-42950	UMLS/C0442030	denotes	rovacuol
T23789	41616-41620	UMLS/C1511726	denotes	neu
T23790	41998-42002	UMLS/C1511726	denotes	nvol
T23791	40995-41003	UMLS/C0007776	denotes	al compl
T23792	41587-41602	UMLS/C0007776	denotes	. The hippocamp
T23793	42951-42966	UMLS/C0007776	denotes	ted neurons and
T23794	43126-43134	UMLS/C0007776	denotes	oles was
T23796	41096-41109	UMLS/C0030560	denotes	PGC-1α+/+, 1,
T23797	41713-41728	UMLS/C0030560	denotes	of the neuropil
T23798	41851-41862	UMLS/C0004083	denotes	he number a
T23799	41246-41255	UMLS/C1314939	denotes	and indiv
T23800	42036-42044	UMLS/C1314939	denotes	ly rare
T23801	41309-41313	UP/Q96R06	denotes	bral
T23802	40714-40727	UMLS/C1704258	denotes	Abnormalities
T23803	40845-40858	UMLS/C1704258	denotes	ies of the br
T23804	40995-41003	UMLS/C0022655	denotes	al compl
T23805	43126-43134	UMLS/C0022655	denotes	oles was
T23806	42887-42890	UMLS/C2347597	denotes	pa
T23807	42083-42093	UMLS/C1980010	denotes	urons were
T23808	43232-43242	UMLS/C1980010	denotes	cytic cell
T23809	40784-40793	UMLS/C0038951	denotes	ying the
T23810	41690-41696	UMLS/C0700321	denotes	rtex.
T23811	41080-41088	UMLS/C0700320	denotes	parieta
T23812	42222-42234	UMLS/C0442165	denotes	rates were n
T23813	42981-42989	UMLS/C0392148	denotes	re 10B).
T23814	41519-41527	UMLS/C0205217	denotes	ytic pro
T23815	41877-41885	UMLS/C0205217	denotes	glial f
T23816	42166-42183	UMLS/C0007759	denotes	eration nor periv
T23817	40986-40994	UMLS/C0228174	denotes	al neuro
T23818	41220-41225	UMLS/C1504310	denotes	on in
T23819	42005-42010	UMLS/C1504310	denotes	mult
T23820	41690-41696	UMLS/C0547044	denotes	rtex.
T23821	43103-43110	UMLS/C0449450	denotes	ocaliza
T23822	43243-43251	UMLS/C0021223	denotes	, presyn
T23823	41627-41638	UMLS/C1284077	denotes	icrovacuola
T23824	41468-41499	UP/P47819	denotes	in, failed to show an increase
T23825	42166-42183	UMLS/C1284087	denotes	eration nor periv
T23826	42235-42853	UMLS/C2674297	denotes	ted in the PGC-1α−/− CNS. Figure 10 Neuropathology of the Central Nervous System of PGC-1α−/− Mice (A) Light microscopic appearance of representative cerebral cortex of 2-mo-old PGC-1α−/− mice demonstrates marked vacuolation of the neuropil (arrows) and scattered neuronal perikarya, which are absent in PGC-1α+/+ mice (hematoxylin and eosin). The scale bar shown is applicable to all sections. (B) Ultrastructural appearance of typical vacuoles containing membranous debris, denoted by the arrow, in the cerebral cortex of a representative PGC-1α−/− mouse in comparison to PGC-1α+/+ (magnification 4000×). Ultrastruc
T23827	41627-41638	UMLS/C0019564	denotes	icrovacuola
T23828	40798-40805	UMLS/C0040300	denotes	es of t
T23829	43053-43063	UMLS/C1549781	denotes	ent in a s
T23830	41027-41033	UMLS/C1274040	denotes	d by m
T23831	41027-41033	UMLS/C0332294	denotes	d by m
T23832	41824-41831	UMLS/C0034169	denotes	with a
T23833	41824-41831	UMLS/C1281335	denotes	with a
T23834	43053-43063	UMLS/C2700400	denotes	ent in a s
T23835	40887-40892	UMLS/C1306462	denotes	oscop
T23836	41531-41538	UMLS/C0237753	denotes	es in P
T23837	41893-41899	UMLS/C0237753	denotes	y acid
T23838	41047-41058	UMLS/C0242485	denotes	neuron dens
T23839	41314-41343	UMLS/C2337405	denotes	cortex were noted in the PGC-
T23840	42133-42143	UMLS/C1550043	denotes	cortex. Ne
T23841	41004-41012	UMLS/C0521390	denotes	ment, a
T23842	41651-41659	UMLS/C0521390	denotes	to a les
T23843	41553-41562	UMLS/C1550044	denotes	cerebral
T23844	41975-41984	UMLS/C1550044	denotes	microvacu
T23845	41851-41862	UMLS/C0699792	denotes	he number a
T23846	43156-43168	UMLS/C0475264	denotes	h; some may
T23847	41027-41033	UMLS/C1280519	denotes	d by m
T23848	40714-40727	UMLS/C0000768	denotes	Abnormalities
T23849	40845-40858	UMLS/C0000768	denotes	ies of the br
T23850	41386-41389	UMLS/C1518422	denotes	re
T23851	40714-40727	UMLS/C0000769	denotes	Abnormalities
T23852	40845-40858	UMLS/C0000769	denotes	ies of the br
T23853	41697-41703	UMLS/C2348088	denotes	icrova
T23854	41851-41862	UMLS/C1704770	denotes	he number a
T23855	41851-41862	UMLS/C1704771	denotes	he number a
T23856	41195-41210	UMLS/C1273937	denotes	y areas of micr
T23857	43078-43088	UMLS/C0205287	denotes	al neurons
T23858	41027-41033	UMLS/C1546471	denotes	d by m
T23859	43053-43063	UMLS/C0332256	denotes	ent in a s
T23860	41069-41076	UMLS/C0178587	denotes	ions of
T23861	41273-41283	UMLS/C1550471	denotes	urons of t
T23862	43218-43221	UMLS/C0337876	denotes	eri
T23863	42908-42919	UMLS/C0582103	denotes	rtex confir
T23864	41468-41499	UP/P03995	denotes	in, failed to show an increase
T23865	43218-43221	UMLS/C0454788	denotes	eri
T23866	41627-41638	UMLS/C1029104	denotes	icrovacuola
T23867	42908-42919	UMLS/C0031809	denotes	rtex confir
T23868	41013-41023	UMLS/C0009498	denotes	esult conf
T23869	41501-41507	UMLS/C0231175	denotes	numbe
T23870	40935-40947	UMLS/C0459385	denotes	mples demons
T23871	41553-41562	UMLS/C1184743	denotes	cerebral
T23872	41975-41984	UMLS/C1184743	denotes	microvacu
T23873	43243-43251	UMLS/C0013879	denotes	, presyn
T23874	41080-41088	UMLS/C1551341	denotes	parieta
T23875	41468-41499	UMLS/C1415042	denotes	in, failed to show an increase
T23876	43189-43198	UMLS/C0332218	denotes	elements
T23877	41697-41703	UMLS/C0441889	denotes	icrova
T23878	41034-41043	UMLS/C1446409	denotes	asurement
T23879	42967-42976	UMLS/C1446409	denotes	neuropil
T23880	41460-41466	UMLS/C0005516	denotes	ic pro
T23881	41468-41499	UP/P48677	denotes	in, failed to show an increase
T23882	41220-41225	UMLS/C0017446	denotes	on in
T23883	42005-42010	UMLS/C0017446	denotes	mult
T23884	42064-42071	UMLS/C0017446	denotes	and gra
T23885	42064-42071	UMLS/C1514562	denotes	and gra
T23886	41697-41703	UMLS/C0542560	denotes	icrova
T23887	42073-42077	UMLS/C1720467	denotes	le c
T23888	43078-43088	UMLS/C0025255	denotes	al neurons
T23889	41062-41068	UMLS/C0027882	denotes	in sec
T23890	41135-41142	UMLS/C0027882	denotes	s PGC-1
T23891	41182-41189	UMLS/C0027882	denotes	icant).
T23892	41294-41301	UMLS/C0027882	denotes	ers of
T23893	41767-41774	UMLS/C0027882	denotes	glia (c
T23894	42120-42127	UMLS/C0027882	denotes	− cereb
T23895	43009-43016	UMLS/C0027882	denotes	aggreg
T23896	43135-43142	UMLS/C0027882	denotes	difficu
T33779	58575-58584	UMLS/C0036576	denotes	on was pe
T33780	58967-58975	UMLS/C1720154	denotes	yst. Chi
T33781	57911-57914	UMLS/C1272693	denotes	gin
T33782	58914-58917	UMLS/C1272693	denotes	en
T33783	58947-58950	UMLS/C1272693	denotes	o a
T33784	57932-57940	UMLS/C0522505	denotes	am of ex
T33785	57956-57964	UMLS/C0522505	denotes	am of an
T33786	57911-57914	UMLS/C1561490	denotes	gin
T33787	58914-58917	UMLS/C1561490	denotes	en
T33788	58947-58950	UMLS/C1561490	denotes	o a
T33789	58187-58197	UMLS/C0522506	denotes	on 5 was a
T33790	57855-57861	UMLS/C0206415	denotes	er was
T33791	58049-58055	UMLS/C0206415	denotes	ined a
T33792	58307-58314	UMLS/C0206415	denotes	y (5′-
T33793	57612-57615	UMLS/C0007120	denotes	AC
T33794	58652-58661	UMLS/C1820374	denotes	ersity (S
T33795	58262-58267	UMLS/C1515974	denotes	eered
T33796	57803-57807	UMLS/C0015295	denotes	on 3
T33797	57944-57948	UMLS/C0015295	denotes	jus
T33798	58201-58205	UMLS/C0015295	denotes	fied
T33799	59071-59080	UMLS/C0750484	denotes	f tail DN
T33800	58171-58177	UMLS/C1561503	denotes	downst
T33801	59018-59023	UMLS/C1260875	denotes	ine t
T33802	58106-58111	UMLS/C1880279	denotes	in lo
T33803	57987-58003	UMLS/C1882940	denotes	ction site (5′-
T33804	58171-58177	UMLS/C2348168	denotes	downst
T33805	57875-57877	UMLS/C0319022	denotes	mp
T33806	59024-59026	UMLS/C0319022	denotes	an
T33807	57888-57896	UMLS/C0392767	denotes	ment wit
T33808	58178-58186	UMLS/C0392767	denotes	eam of e
T33809	58408-58417	UMLS/C0392767	denotes	1339-PGK-
T33810	58171-58177	UMLS/C1705190	denotes	downst
T33811	57731-57739	UMLS/C0887950	denotes	nomics (
T33812	57612-57615	UMLS/C0684262	denotes	AC
T33813	58665-58675	UMLS/C0043038	denotes	ouis, Miss
T33814	57915-57924	UMLS/C1561554	denotes	ing 732 b
T33815	59054-59066	UMLS/C0040722	denotes	uthern blott
T33816	57764-57777	UMLS/C0041703	denotes	ited States).
T33817	58709-58722	UMLS/C0041703	denotes	ere screened
T33818	58273-58283	UMLS/C0878517	denotes	the 5′ and
T33819	59071-59080	UMLS/C1456348	denotes	f tail DN
T33820	58676-58686	UMLS/C0041740	denotes	uri, Unite
T33821	57787-57793	UMLS/C0205147	denotes	gion s
T33822	58262-58267	UMLS/C0205145	denotes	eered
T33823	59018-59023	UMLS/C0682323	denotes	ine t
T33824	59071-59080	UMLS/C0521093	denotes	f tail DN
T33825	58610-58619	UMLS/C1550369	denotes	cer Cente
T33826	59152-59161	UMLS/C1550369	denotes	ched or l
T33827	57612-57615	UMLS/C0887889	denotes	AC
T33828	59135-59146	UMLS/C0681814	denotes	sex- and a
T33829	59168-59172	UMLS/C1879943	denotes	te c
T33830	58106-58111	UMLS/C0178499	denotes	in lo
T33831	57666-57674	UMLS/C1546680	denotes	olated f
T33832	58171-58177	UMLS/C0457385	denotes	downst
T33833	58610-58619	UMLS/C0884358	denotes	cer Cente
T33834	59152-59161	UMLS/C0884358	denotes	ched or l
T33835	57794-57802	UMLS/C1711300	denotes	anning e
T33836	58464-58470	UMLS/C1705099	denotes	neariz
T33837	58753-58766	UMLS/C0005862	denotes	digest (see F
T33838	59084-59101	UMLS/C0005862	denotes	ee Figure 1B). Al
T33839	58741-58749	UMLS/C0220909	denotes	ing an X
T33840	58847-58855	UMLS/C0220909	denotes	e homolo
T33841	58741-58749	UMLS/C0220908	denotes	ing an X
T33842	58847-58855	UMLS/C0220908	denotes	e homolo
T33843	58741-58749	UMLS/C1705053	denotes	ing an X
T33844	58847-58855	UMLS/C1705053	denotes	e homolo
T33845	58781-58787	UMLS/C0012237	denotes	). One
T33846	58741-58749	UMLS/C1305399	denotes	ing an X
T33847	58847-58855	UMLS/C1305399	denotes	e homolo
T33848	58262-58267	UMLS/C2347790	denotes	eered
T33849	57710-57718	UMLS/C1301820	denotes	tained f
T33850	59004-59012	UMLS/C0008109	denotes	mice and
T33851	58464-58470	UMLS/C0442335	denotes	neariz
T33852	59004-59012	UMLS/C1262946	denotes	mice and
T33853	59105-59109	UMLS/C0039259	denotes	peri
T33854	58106-58111	UMLS/C1704464	denotes	in lo
T33855	57645-57651	UMLS/C0026809	denotes	urine
T33856	58555-58562	UMLS/C1711343	denotes	n. The
T33857	58741-58749	UMLS/C1698960	denotes	ing an X
T33858	58847-58855	UMLS/C1698960	denotes	e homolo
T33859	57645-57651	UMLS/C0026802	denotes	urine
T33860	58273-58283	UMLS/C0014279	denotes	the 5′ and
T33861	57624-57629	UMLS/C1522642	denotes	lone
T33862	57841-57846	UMLS/C1522642	denotes	one.
T33863	58423-58429	UMLS/C1522642	denotes	in tar
T33864	58729-58735	UMLS/C1522642	denotes	hern b
T33865	58816-58821	UMLS/C1522642	denotes	00 sc
T33866	58957-58962	UMLS/C1522642	denotes	/J bl
T33867	58635-58648	UMLS/C1516172	denotes	t Washington
T33868	58753-58766	UMLS/C1148472	denotes	digest (see F
T33869	59084-59101	UMLS/C1148472	denotes	ee Figure 1B). Al
T33870	57645-57651	UMLS/C0591833	denotes	urine
T33871	57710-57718	UMLS/C1706701	denotes	tained f
T33872	57616-57623	UMLS/C0017428	denotes	enomic
T33873	57833-57840	UMLS/C0017428	denotes	nomic c
T33874	58807-58809	UMLS/C0450345	denotes	im
T33875	59126-59128	UMLS/C0450345	denotes	me
T33876	57689-57704	UMLS/C0017430	denotes	nomic library,
T33877	58093-58101	UMLS/C0026882	denotes	bases s
T33878	58570-58574	UMLS/C0052009	denotes	orat
T33879	58800-58802	UMLS/C0450344	denotes	a
T33880	59168-59172	UMLS/C0036864	denotes	te c
T33881	58741-58749	UMLS/C0199230	denotes	ing an X
T33882	58847-58855	UMLS/C0199230	denotes	e homolo
T33883	58860-58872	UMLS/C1446409	denotes	recombinatio
T33884	59071-59080	UMLS/C1446409	denotes	f tail DN
T33885	57624-57629	UMLS/C0009013	denotes	lone
T33886	57841-57846	UMLS/C0009013	denotes	one.
T33887	58423-58429	UMLS/C0009013	denotes	in tar
T33888	58729-58735	UMLS/C0009013	denotes	hern b
T33889	58816-58821	UMLS/C0009013	denotes	00 sc
T33890	58957-58962	UMLS/C0009013	denotes	/J bl
T33891	58262-58267	UMLS/C1546778	denotes	eered
T33892	57787-57793	UMLS/C0017446	denotes	gion s
T33893	57787-57793	UMLS/C1514562	denotes	gion s
T33894	57624-57629	UMLS/C0009015	denotes	lone
T33895	57841-57846	UMLS/C0009015	denotes	one.
T33896	58423-58429	UMLS/C0009015	denotes	in tar
T33897	58729-58735	UMLS/C0009015	denotes	hern b
T33898	58816-58821	UMLS/C0009015	denotes	00 sc
T33899	58957-58962	UMLS/C0009015	denotes	/J bl
T33900	57794-57802	UMLS/C2700613	denotes	anning e
T33901	58992-59002	UMLS/C1281743	denotes	to C57BL6/
T33902	58925-58934	UMLS/C1883719	denotes	clone was
T33903	57929-57931	UMLS/C1841672	denotes	tr
T33904	58992-59002	UMLS/C0005705	denotes	to C57BL6/
T33905	58781-58787	UMLS/C0868946	denotes	). One
T33906	59135-59146	UMLS/C1706386	denotes	sex- and a
T33907	59168-59172	UMLS/C1522384	denotes	te c
T33908	58171-58177	UMLS/C0565930	denotes	downst
T33909	57888-57896	UMLS/C0332472	denotes	ment wit
T33910	58178-58186	UMLS/C0332472	denotes	eam of e
T33911	58408-58417	UMLS/C0332472	denotes	1339-PGK-
T33912	57666-57674	UMLS/C0205409	denotes	olated f
T33913	58925-58934	UMLS/C1512796	denotes	clone was
T33914	58590-58605	UMLS/C0206691	denotes	d by the Sitema
T33915	58699-58707	UMLS/C0026222	denotes	e clones
T33916	59110-59113	UMLS/C1325786	denotes	ent
T33917	59018-59023	UMLS/C0874159	denotes	ine t
T33918	58106-58111	UMLS/C1549548	denotes	in lo
T33919	57752-57762	UMLS/C0006754	denotes	lifornia,
T33920	57612-57615	UMLS/C0004599	denotes	AC
T33921	58106-58111	UMLS/C1626935	denotes	in lo
T33922	57888-57896	UMLS/C0486805	denotes	ment wit
T33923	58178-58186	UMLS/C0486805	denotes	eam of e
T33924	58408-58417	UMLS/C0486805	denotes	1339-PGK-
T33925	58812-58815	UMLS/C0205447	denotes	ly
T33926	58074-58089	UMLS/C0402297	denotes	red by mutating
T33927	57855-57861	UMLS/C0205435	denotes	er was
T33928	58049-58055	UMLS/C0205435	denotes	ined a
T33929	58307-58314	UMLS/C0205435	denotes	y (5′-
T33930	58171-58177	UMLS/C0205436	denotes	downst
T33931	57666-57674	UMLS/C0370215	denotes	olated f
T33932	57915-57924	UMLS/C0439659	denotes	ing 732 b
T33933	59054-59066	UMLS/C0242781	denotes	uthern blott
T33934	58106-58111	UMLS/C1550601	denotes	in lo
T33935	57911-57914	UMLS/C0444930	denotes	gin
T33936	58914-58917	UMLS/C0444930	denotes	en
T33937	58947-58950	UMLS/C0444930	denotes	o a
T33938	57855-57861	UMLS/C1279901	denotes	er was
T33939	58049-58055	UMLS/C1279901	denotes	ined a
T33940	58307-58314	UMLS/C1279901	denotes	y (5′-
T33941	58822-58825	UMLS/C0849355	denotes	een
T33942	59004-59012	UMLS/C1318484	denotes	mice and
T33943	59054-59066	UMLS/C1521797	denotes	uthern blott
T33944	57911-57914	UMLS/C1522314	denotes	gin
T33945	58914-58917	UMLS/C1522314	denotes	en
T33946	58947-58950	UMLS/C1522314	denotes	o a
T33947	58476-58485	UMLS/C0012931	denotes	h Xho1 an
T33948	58555-58562	UMLS/C2348040	denotes	n. The
T33949	57971-57981	UMLS/C0205227	denotes	nous Kpn1
T33950	58106-58111	UMLS/C1705938	denotes	in lo
T33951	57888-57896	UMLS/C1708096	denotes	ment wit
T33952	58178-58186	UMLS/C1708096	denotes	eam of e
T33953	58408-58417	UMLS/C1708096	denotes	1339-PGK-
T33954	57575-57584	UMLS/C1521840	denotes	Targeting
T33955	58454-58463	UMLS/C1521840	denotes	uct was l
T33956	57630-57640	UMLS/C1549781	denotes	ontaining
T33957	58056-58065	UMLS/C1549781	denotes	BamH1 sit
T33958	58464-58470	UMLS/C0086022	denotes	neariz
T33959	57746-57750	UMLS/C0205250	denotes	to,
T33960	57752-57762	UMLS/C0324542	denotes	lifornia,
T33961	57630-57640	UMLS/C2700400	denotes	ontaining
T33962	58056-58065	UMLS/C2700400	denotes	BamH1 sit
T33963	59110-59113	UMLS/C0012854	denotes	ent
T33964	57575-57584	UMLS/C0599894	denotes	Targeting
T33965	58454-58463	UMLS/C0599894	denotes	uct was l
T33966	58093-58101	UMLS/C1513776	denotes	bases s
T33967	58925-58934	UMLS/C1705421	denotes	clone was
T33968	58539-58547	UMLS/C0596508	denotes	ng G418
T33969	58649-58656	UMLS/C0596508	denotes	niversi
T33970	57666-57674	UMLS/C1548221	denotes	olated f
T33971	58992-59002	UMLS/C1281786	denotes	to C57BL6/
T33972	57666-57674	UMLS/C1764827	denotes	olated f
T33973	58555-58562	UMLS/C1441547	denotes	n. The
T33974	58789-58792	UMLS/C0042789	denotes	lon
T33975	59115-59118	UMLS/C0042789	denotes	wer
T33976	57630-57640	UMLS/C0332256	denotes	ontaining
T33977	58056-58065	UMLS/C0332256	denotes	BamH1 sit
T33978	57888-57896	UMLS/C0332255	denotes	ment wit
T33979	58178-58186	UMLS/C0332255	denotes	eam of e
T33980	58408-58417	UMLS/C0332255	denotes	1339-PGK-
T33981	58877-58901	UMLS/C0599773	denotes	the 3′ end and an insert
T33982	58741-58749	UMLS/C1710031	denotes	ing an X
T33983	58847-58855	UMLS/C1710031	denotes	e homolo
T33984	59168-59172	UMLS/C1314687	denotes	te c
T33985	58741-58749	UMLS/C0430054	denotes	ing an X
T33986	58847-58855	UMLS/C0430054	denotes	e homolo
T33987	58822-58825	UMLS/C0439787	denotes	een
T33988	58925-58934	UMLS/C0441587	denotes	clone was
T33989	58226-58230	UMLS/C0323983	denotes	icon
T33990	58952-58956	UMLS/C0323983	denotes	57BL
T33991	58829-58842	UMLS/C0332232	denotes	as positive f
T35065	59389-59397	UMLS/C1709941	denotes	reviewed
T35066	59389-59397	UMLS/C1709940	denotes	reviewed
T35067	59513-59517	UMLS/C0024554	denotes	Male
T35068	59847-59851	UMLS/C0024554	denotes	nd f
T35069	59930-59934	UMLS/C0024554	denotes	ale
T35070	59252-59261	UMLS/C1522729	denotes	protocols
T35071	59389-59397	UMLS/C1552617	denotes	reviewed
T35072	60266-60269	UMLS/C0035668	denotes	rac
T35073	60447-60450	UMLS/C0035668	denotes	Pho
T35074	60982-61003	UMLS/C2718082	denotes	es and compared acros
T35075	60298-60305	UMLS/C0456962	denotes	imals w
T35076	60207-60210	UMLS/C1272693	denotes	re
T35077	60207-60210	UMLS/C1561490	denotes	re
T35078	59218-59236	UMLS/C0205664	denotes	animal experiments
T35079	60090-60095	UMLS/C1704681	denotes	nd ev
T35080	59993-59999	UMLS/C1704678	denotes	at 4 °
T35081	60335-60341	UMLS/C1704678	denotes	ter ad
T35082	60090-60095	UMLS/C0182400	denotes	nd ev
T35083	59737-59744	UMLS/C0947630	denotes	s were
T35084	60306-60313	UMLS/C0947630	denotes	re sing
T35085	60004-60010	UMLS/C1882509	denotes	5 h w
T35086	59600-59607	UMLS/C1547928	denotes	s were
T35087	59661-59667	UMLS/C1547928	denotes	weigh
T35088	60229-60239	UMLS/C0681205	denotes	ues harves
T35089	59532-59534	UMLS/C0319022	denotes	to
T35090	60177-60179	UMLS/C0319022	denotes	gy
T35091	60083-60089	UMLS/C0205052	denotes	eline
T35092	59359-59368	UMLS/C0039798	denotes	treatment
T35093	60466-60477	UMLS/C0031749	denotes	mice was pe
T35094	59641-59659	UMLS/C0492524	denotes	ical balance. Tiss
T35095	60944-60953	UMLS/C0700158	denotes	lated for
T35096	60358-60368	UMLS/C1879743	denotes	s removed
T35097	59668-59675	UMLS/C0944911	denotes	s were
T35098	59701-59712	UMLS/C0944911	denotes	eight befor
T35099	59737-59744	UMLS/C1880229	denotes	s were
T35100	60306-60313	UMLS/C1880229	denotes	re sing
T35101	59443-59453	UMLS/C0043038	denotes	Washington
T35102	60517-60527	UMLS/C0043038	denotes	ty School
T35103	59681-59690	UMLS/C0205170	denotes	ted for t
T35104	60539-60545	UMLS/C1556012	denotes	48-h
T35105	60405-60412	UMLS/C0332170	denotes	harves
T35106	60668-60681	UMLS/C0041703	denotes	g a Comprehen
T35107	60787-60800	UMLS/C0041703	denotes	efly, 3-mo-ol
T35108	59359-59368	UMLS/C1705169	denotes	treatment
T35109	59500-59511	UMLS/C2348792	denotes	time points
T35110	59454-59464	UMLS/C0041740	denotes	University
T35111	60528-60538	UMLS/C0041740	denotes	f Medicine
T35112	60274-60281	UMLS/C0033684	denotes	For fa
T35113	59337-59347	UMLS/C0282423	denotes	guidelines
T35114	60042-60064	UMLS/C0456240	denotes	res were monitored by
T35115	60539-60545	UMLS/C0013658	denotes	48-h
T35116	60070-60079	UMLS/C1704646	denotes	probe at
T35117	60145-60154	UMLS/C1704646	denotes	every 30
T35118	60573-60583	UMLS/C1704646	denotes	ormed by J
T35119	60723-60733	UMLS/C1704646	denotes	CLAMS, Col
T35120	59668-59675	UMLS/C0043100	denotes	s were
T35121	59750-59759	UMLS/C1550369	denotes	med as pr
T35122	60494-60503	UMLS/C1550369	denotes	at Washi
T35123	60588-60597	UMLS/C1550369	denotes	rvices (T
T35124	59389-59397	UMLS/C0282443	denotes	reviewed
T35125	59917-59928	UMLS/C0681814	denotes	male and f
T35126	60346-60351	UMLS/C1947971	denotes	tum.
T35127	60564-60572	UMLS/C1561536	denotes	was per
T35128	59267-59276	UMLS/C1267211	denotes	conducted
T35129	59267-59276	UMLS/C0441247	denotes	conducted
T35130	60455-60464	UMLS/C0019638	denotes	phy of th
T35131	60392-60397	UMLS/C0441239	denotes	g and
T35132	59668-59675	UMLS/C1705104	denotes	s were
T35133	60070-60079	UMLS/C0728873	denotes	probe at
T35134	60145-60154	UMLS/C0728873	denotes	every 30
T35135	60573-60583	UMLS/C0728873	denotes	ormed by J
T35136	60723-60733	UMLS/C0728873	denotes	CLAMS, Col
T35137	59750-59759	UMLS/C0884358	denotes	med as pr
T35138	60494-60503	UMLS/C0884358	denotes	at Washi
T35139	60588-60597	UMLS/C0884358	denotes	rvices (T
T35140	59252-59261	UMLS/C2349977	denotes	protocols
T35141	59737-59744	UMLS/C2349977	denotes	s were
T35142	60306-60313	UMLS/C2349977	denotes	re sing
T35143	60090-60095	UMLS/C0728863	denotes	nd ev
T35144	60539-60545	UMLS/C1618606	denotes	48-h
T35145	59737-59744	UMLS/C2603343	denotes	s were
T35146	60306-60313	UMLS/C2603343	denotes	re sing
T35147	59513-59517	UMLS/C1706180	denotes	Male
T35148	59847-59851	UMLS/C1706180	denotes	nd f
T35149	59930-59934	UMLS/C1706180	denotes	ale
T35150	60244-60261	UMLS/C0185110	denotes	or RNA and protei
T35151	60417-60434	UMLS/C0185110	denotes	t 24 h for RNA an
T35152	59402-59410	UMLS/C2346846	denotes	approved
T35153	60070-60079	UMLS/C1516647	denotes	probe at
T35154	60145-60154	UMLS/C1516647	denotes	every 30
T35155	60573-60583	UMLS/C1516647	denotes	ormed by J
T35156	60723-60733	UMLS/C1516647	denotes	CLAMS, Col
T35157	59402-59410	UMLS/C0205540	denotes	approved
T35158	60865-60880	UMLS/C0010995	denotes	ta were collect
T35159	59600-59607	UMLS/C0040300	denotes	s were
T35160	59661-59667	UMLS/C0040300	denotes	weigh
T35161	59402-59410	UMLS/C1549489	denotes	approved
T35162	60298-60305	UMLS/C1550565	denotes	imals w
T35163	60758-60769	UMLS/C0348000	denotes	us, Ohio, U
T35164	60036-60040	UMLS/C0016452	denotes	pera
T35165	60370-60374	UMLS/C0016452	denotes	om c
T35166	59732-59736	UMLS/C1510486	denotes	tudi
T35167	59811-59815	UMLS/C1510486	denotes	yste
T35168	60070-60079	UMLS/C0181904	denotes	probe at
T35169	60145-60154	UMLS/C0181904	denotes	every 30
T35170	60573-60583	UMLS/C0181904	denotes	ormed by J
T35171	60723-60733	UMLS/C0181904	denotes	CLAMS, Col
T35172	60083-60089	UMLS/C0205536	denotes	eline
T35173	59513-59517	UMLS/C0325595	denotes	Male
T35174	59847-59851	UMLS/C0325595	denotes	nd f
T35175	59930-59934	UMLS/C0325595	denotes	ale
T35176	59701-59712	UMLS/C0005910	denotes	eight befor
T35177	59737-59744	UMLS/C0008976	denotes	s were
T35178	60306-60313	UMLS/C0008976	denotes	re sing
T35179	59737-59744	UMLS/C0008972	denotes	s were
T35180	60306-60313	UMLS/C0008972	denotes	re sing
T35181	60180-60185	UMLS/C1948051	denotes	At t
T35182	59267-59276	UMLS/C0004927	denotes	conducted
T35183	59513-59517	UMLS/C0086582	denotes	Male
T35184	59847-59851	UMLS/C0086582	denotes	nd f
T35185	59930-59934	UMLS/C0086582	denotes	ale
T35186	60070-60079	UMLS/C0596972	denotes	probe at
T35187	60145-60154	UMLS/C0596972	denotes	every 30
T35188	60573-60583	UMLS/C0596972	denotes	ormed by J
T35189	60723-60733	UMLS/C0596972	denotes	CLAMS, Col
T35190	60282-60292	UMLS/C0185115	denotes	ting studi
T35191	60164-60169	UMLS/C1948061	denotes	ck fo
T35192	60902-60907	UMLS/C1948061	denotes	beam
T35193	60099-60107	UMLS/C1442488	denotes	hour the
T35194	59479-59486	UMLS/C1305866	denotes	weighed
T35195	59627-59634	UMLS/C1305866	denotes	d on an
T35196	59701-59712	UMLS/C1305866	denotes	eight befor
T35197	60455-60464	UMLS/C0344441	denotes	phy of th
T35198	60922-60926	UMLS/C2347880	denotes	XY d
T35199	59695-59705	UMLS/C0229960	denotes	body weigh
T35200	60379-60391	UMLS/C1292747	denotes	in the morni
T35201	59359-59368	UMLS/C0087111	denotes	treatment
T35202	60892-60901	UMLS/C1516695	denotes	min. Tota
T35203	59337-59347	UMLS/C0220845	denotes	guidelines
T35204	60170-60176	UMLS/C1442458	denotes	letha
T35205	60908-60914	UMLS/C1442458	denotes	breaks
T35206	60781-60785	UMLS/C0028905	denotes	). B
T35207	60944-60953	UMLS/C0449738	denotes	lated for
T35208	60298-60305	UMLS/C0015663	denotes	imals w
T35209	60892-60901	UMLS/C1516698	denotes	min. Tota
T35210	59490-59499	UMLS/C1705242	denotes	different
T35211	59720-59730	UMLS/C1707455	denotes	ison. DEXA
T35212	59522-59528	UMLS/C0086287	denotes	female
T35213	59856-59862	UMLS/C0086287	denotes	PGC-1
T35214	59939-59945	UMLS/C0086287	denotes	α+/+ a
T35215	60821-60827	UMLS/C0086287	denotes	climat
T35216	59241-59251	UMLS/C0015187	denotes	euthanasia
T35217	59191-59198	UMLS/C1553889	denotes	General
T35218	60346-60351	UMLS/C1550718	denotes	tum.
T35219	60944-60953	UMLS/C1550715	denotes	lated for
T35220	59737-59744	UMLS/C0557651	denotes	s were
T35221	60306-60313	UMLS/C0557651	denotes	re sing
T35222	60164-60169	UMLS/C1720374	denotes	ck fo
T35223	60902-60907	UMLS/C1720374	denotes	beam
T35224	60549-60557	UMLS/C0025118	denotes	vity mon
T35225	60090-60095	UMLS/C0419358	denotes	nd ev
T35226	59522-59528	UMLS/C0015780	denotes	female
T35227	59856-59862	UMLS/C0015780	denotes	PGC-1
T35228	59939-59945	UMLS/C0015780	denotes	α+/+ a
T35229	60821-60827	UMLS/C0015780	denotes	climat
T35230	59252-59261	UMLS/C1507394	denotes	protocols
T35231	59917-59928	UMLS/C1706386	denotes	male and f
T35232	60266-60269	UMLS/C1325819	denotes	rac
T35233	60447-60450	UMLS/C1325819	denotes	Pho
T35234	59816-59822	UMLS/C1704459	denotes	at 10
T35235	60734-60740	UMLS/C1704459	denotes	mbus I
T35236	60346-60351	UMLS/C1442162	denotes	tum.
T35237	60170-60176	UMLS/C0456693	denotes	letha
T35238	60908-60914	UMLS/C0456693	denotes	breaks
T35239	60455-60464	UMLS/C1552405	denotes	phy of th
T35240	60564-60572	UMLS/C0441655	denotes	was per
T35241	59372-59379	UMLS/C0003062	denotes	animals
T35242	59466-59473	UMLS/C0003062	denotes	Animals
T35243	60315-60322	UMLS/C0003062	denotes	housed
T35244	60705-60722	UMLS/C0003064	denotes	onitoring System
T35245	60656-60666	UMLS/C0006754	denotes	States) us
T35246	59816-59822	UMLS/C0449913	denotes	at 10
T35247	60734-60740	UMLS/C0449913	denotes	mbus I
T35248	59418-59439	UMLS/C0003045	denotes	Animal Care Committee
T35249	60112-60122	UMLS/C0558292	denotes	er. Mice w
T35250	60549-60557	UMLS/C0013227	denotes	vity mon
T35251	60099-60107	UMLS/C1552824	denotes	hour the
T35252	59816-59822	UMLS/C1553451	denotes	at 10
T35253	60734-60740	UMLS/C1553451	denotes	mbus I
T35254	60455-60464	UMLS/C0205462	denotes	phy of th
T35255	59199-59213	UMLS/C0683949	denotes	animal studies
T35256	60099-60107	UMLS/C0168634	denotes	hour the
T35257	60207-60210	UMLS/C0444930	denotes	re
T35258	60070-60079	UMLS/C0150369	denotes	probe at
T35259	60145-60154	UMLS/C0150369	denotes	every 30
T35260	60573-60583	UMLS/C0150369	denotes	ormed by J
T35261	60723-60733	UMLS/C0150369	denotes	CLAMS, Col
T35262	59359-59368	UMLS/C1533734	denotes	treatment
T35263	59402-59410	UMLS/C1706842	denotes	approved
T35264	60944-60953	UMLS/C0522247	denotes	lated for
T35265	60882-60886	UMLS/C1511726	denotes	eve
T35266	59389-59397	UMLS/C1704362	denotes	reviewed
T35267	59337-59347	UMLS/C0162791	denotes	guidelines
T35268	59993-59999	UMLS/C0020056	denotes	at 4 °
T35269	60335-60341	UMLS/C0020056	denotes	ter ad
T35270	60564-60572	UMLS/C0439167	denotes	was per
T35271	60090-60095	UMLS/C2347609	denotes	nd ev
T35272	60944-60953	UMLS/C0439755	denotes	lated for
T35273	60916-60921	UMLS/C0439175	denotes	n the
T35274	59993-59999	UMLS/C2003847	denotes	at 4 °
T35275	60335-60341	UMLS/C2003847	denotes	ter ad
T35276	59681-59690	UMLS/C0205202	denotes	ted for t
T35277	59737-59744	UMLS/C1705923	denotes	s were
T35278	60306-60313	UMLS/C1705923	denotes	re sing
T35279	59267-59276	UMLS/C0337115	denotes	conducted
T35280	60207-60210	UMLS/C1522314	denotes	re
T35281	60539-60545	UMLS/C0036375	denotes	48-h
T35282	60539-60545	UMLS/C1552273	denotes	48-h
T35283	60083-60089	UMLS/C1527425	denotes	eline
T35284	60691-60704	UMLS/C1880156	denotes	atory Animal
T35285	59613-59622	UMLS/C0205239	denotes	ted and w
T35286	60605-60613	UMLS/C1704289	denotes	on Labor
T35287	60539-60545	UMLS/C1552255	denotes	48-h
T35288	59191-59198	UMLS/C0205246	denotes	General
T35289	60282-60292	UMLS/C0684295	denotes	ting studi
T35290	60656-60666	UMLS/C0324542	denotes	States) us
T35291	60090-60095	UMLS/C1442917	denotes	nd ev
T35292	60539-60545	UMLS/C1617581	denotes	48-h
T35293	59252-59261	UMLS/C2348563	denotes	protocols
T35294	59252-59261	UMLS/C0442711	denotes	protocols
T35295	60455-60464	UMLS/C1608506	denotes	phy of th
T35296	59774-59783	UMLS/C1552738	denotes	bed [39]
T35297	59841-59843	UMLS/C0439230	denotes	ma
T35298	60539-60545	UMLS/C1555917	denotes	48-h
T35299	59903-59916	UMLS/C0231275	denotes	e experiments
T35300	59389-59397	UMLS/C0699752	denotes	reviewed
T35301	60927-60933	UMLS/C1881704	denotes	rectio
T35302	60070-60079	UMLS/C1521743	denotes	probe at
T35303	60145-60154	UMLS/C1521743	denotes	every 30
T35304	60573-60583	UMLS/C1521743	denotes	ormed by J
T35305	60723-60733	UMLS/C1521743	denotes	CLAMS, Col
T35306	59513-59517	UMLS/C1706429	denotes	Male
T35307	59847-59851	UMLS/C1706429	denotes	nd f
T35308	59930-59934	UMLS/C1706429	denotes	ale
T35309	59681-59690	UMLS/C2349182	denotes	ted for t
T35310	59513-59517	UMLS/C1706428	denotes	Male
T35311	59847-59851	UMLS/C1706428	denotes	nd f
T35312	59930-59934	UMLS/C1706428	denotes	ale
T35313	60392-60397	UMLS/C0337189	denotes	g and
T35314	60004-60010	UMLS/C1704765	denotes	5 h w
T35315	60539-60545	UMLS/C1608526	denotes	48-h
T35316	60916-60921	UMLS/C0439810	denotes	n the
T35317	60605-60613	UMLS/C0557854	denotes	on Labor
T35318	59307-59336	UMLS/C0027468	denotes	National Institutes of Health
T35319	59359-59368	UMLS/C1522326	denotes	treatment
T35320	60601-60604	UMLS/C1515351	denotes	ack
T35321	60619-60637	UMLS/C1515351	denotes	West Sacramento,
T35322	60190-60198	UMLS/C0023380	denotes	d of 5 h
T35323	59522-59528	UMLS/C1705497	denotes	female
T35324	59856-59862	UMLS/C1705497	denotes	PGC-1
T35325	59939-59945	UMLS/C1705497	denotes	α+/+ a
T35326	60821-60827	UMLS/C1705497	denotes	climat
T35327	59522-59528	UMLS/C1705498	denotes	female
T35328	59856-59862	UMLS/C1705498	denotes	PGC-1
T35329	59939-59945	UMLS/C1705498	denotes	α+/+ a
T35330	60821-60827	UMLS/C1705498	denotes	climat
T35331	60639-60643	UMLS/C1705493	denotes	lifo
T36397	61857-61862	UMLS/C1706074	denotes	The
T36398	61857-61862	UMLS/C1706073	denotes	The
T36399	62297-62300	UMLS/C1551386	denotes	ans
T36400	61589-61593	UMLS/C0008848	denotes	ifor
T36401	61017-61020	UMLS/C0035668	denotes	RNA
T36402	61054-61057	UMLS/C0035668	denotes	RNA
T36403	61398-61401	UMLS/C0035668	denotes	NA
T36404	62132-62136	UMLS/C0445247	denotes	to
T36405	61871-61878	UMLS/C0206415	denotes	or UCP-
T36406	62086-62093	UMLS/C0206415	denotes	Applied
T36407	61724-61732	UMLS/C1561491	denotes	Detector
T36408	61693-61697	UMLS/C1820374	denotes	ents
T36409	61085-61091	UMLS/C0025663	denotes	method
T36410	61085-61091	UMLS/C0025664	denotes	method
T36411	62641-62649	UMLS/C1704680	denotes	f the me
T36412	62205-62212	UMLS/C0947630	denotes	5 μg of
T36413	61116-61121	UMLS/C0039711	denotes	Texas
T36414	61926-61931	UP/Q9P4D1	denotes	mer-p
T36415	61733-61741	UMLS/C1705235	denotes	(Applied
T36416	61926-61931	UP/Q9UVX4	denotes	mer-p
T36417	61552-61560	UMLS/C0034760	denotes	(Applied
T36418	61698-61706	UMLS/C0034760	denotes	and a Pr
T36419	62073-62078	UMLS/C1414968	denotes	ent p
T36420	61806-61808	UMLS/C0319022	denotes	s
T36421	62011-62013	UMLS/C0319022	denotes	iz
T36422	62142-62144	UMLS/C0319022	denotes	iz
T36423	62317-62319	UMLS/C0319022	denotes	Sc
T36424	61796-61800	UMLS/C1552652	denotes	to
T36425	61945-61948	UMLS/C1552652	denotes	ied
T36426	61562-61569	UMLS/C1632850	denotes	iosyste
T36427	61743-61750	UMLS/C1632850	denotes	iosyste
T36428	61950-61957	UMLS/C1632850	denotes	iosyste
T36429	62095-62102	UMLS/C1632850	denotes	iosyste
T36430	61724-61732	UMLS/C0162326	denotes	Detector
T36431	61796-61800	UMLS/C1705195	denotes	to
T36432	61945-61948	UMLS/C1705195	denotes	ied
T36433	61582-61588	UMLS/C0242298	denotes	ty, Ca
T36434	62483-62500	UMLS/C1450278	denotes	escence detection
T36435	61926-61931	UP/P53689	denotes	mer-p
T36436	61926-61931	UP/Q39596	denotes	mer-p
T36437	61693-61697	UMLS/C0444669	denotes	ents
T36438	62205-62212	UMLS/C1880229	denotes	5 μg of
T36439	61796-61800	UMLS/C1318139	denotes	to
T36440	61945-61948	UMLS/C1318139	denotes	ied
T36441	61651-61661	UMLS/C0205174	denotes	e in 96-we
T36442	61205-61208	UMLS/C1428919	denotes	RC
T36443	61997-62001	UMLS/C0205170	denotes	used
T36444	62137-62141	UMLS/C0205170	denotes	orma
T36445	61926-61931	UP/P17128	denotes	mer-p
T36446	61607-61620	UMLS/C0041703	denotes	ates). Reacti
T36447	62372-62385	UMLS/C0041703	denotes	tes) membrane
T36448	62571-62584	UMLS/C0041703	denotes	tes). Ponceau
T36449	62626-62639	UMLS/C0041703	denotes	tes) staining
T36450	61926-61931	UP/O13419	denotes	mer-p
T36451	62305-62316	UMLS/C1299988	denotes	d to a Gene
T36452	61431-61434	UMLS/C0006298	denotes	AT,
T36453	62036-62039	UMLS/C0006298	denotes	hea
T36454	61988-61996	UMLS/C0086972	denotes	well and
T36455	61431-61434	UMLS/C1412726	denotes	AT,
T36456	62036-62039	UMLS/C1412726	denotes	hea
T36457	61031-61038	UMLS/C0033684	denotes	protein
T36458	62547-62557	UMLS/C1551491	denotes	, New Jers
T36459	61926-61931	UP/Q92193	denotes	mer-p
T36460	62297-62300	UMLS/C0017243	denotes	ans
T36461	61693-61697	UMLS/C1882467	denotes	ents
T36462	61149-61158	UMLS/C1550369	denotes	performed
T36463	61353-61362	UMLS/C1550369	denotes	erformed
T36464	61638-61647	UMLS/C1550369	denotes	in tripl
T36465	62436-62445	UMLS/C1550369	denotes	as descri
T36466	62305-62316	UMLS/C0040671	denotes	d to a Gene
T36467	61825-61840	UMLS/C0017262	denotes	ession can be f
T36468	62051-62066	UMLS/C0017262	denotes	ession data. GA
T36469	62165-62180	UMLS/C0017262	denotes	ession data. Fo
T36470	62305-62316	UMLS/C1540850	denotes	d to a Gene
T36471	61926-61931	UP/Q05214	denotes	mer-p
T36472	61062-61070	UMLS/C1546680	denotes	isolated
T36473	61402-61410	UMLS/C1546680	denotes	solated
T36474	61724-61732	UMLS/C1547787	denotes	Detector
T36475	62415-62431	UMLS/C0949466	denotes	otting was perfo
T36476	61926-61931	UP/Q9UVF3	denotes	mer-p
T36477	61149-61158	UMLS/C0884358	denotes	performed
T36479	61638-61647	UMLS/C0884358	denotes	in tripl
T36480	62436-62445	UMLS/C0884358	denotes	as descri
T36481	61926-61931	UP/O81221	denotes	mer-p
T36482	61926-61931	UP/P53455	denotes	mer-p
T36483	62205-62212	UMLS/C2349977	denotes	5 μg of
T36484	62474-62482	UMLS/C2349975	denotes	hemilumi
T36485	62305-62316	UMLS/C1555583	denotes	d to a Gene
T36486	61562-61569	UMLS/C1879355	denotes	iosyste
T36487	61743-61750	UMLS/C1879355	denotes	iosyste
T36488	61950-61957	UMLS/C1879355	denotes	iosyste
T36489	62095-62102	UMLS/C1879355	denotes	iosyste
T36490	61440-61445	UMLS/C1281570	denotes	eart
T36491	62045-62050	UMLS/C1281570	denotes	e exp
T36492	62205-62212	UMLS/C2603343	denotes	5 μg of
T36493	62191-62204	UMLS/C0005862	denotes	blot studies,
T36494	62415-62431	UMLS/C0005863	denotes	otting was perfo
T36495	61127-61144	UMLS/C0005861	denotes	Northern blotting
T36496	62587-62596	UMLS/C0071720	denotes	(Sigma, S
T36497	62305-62316	UMLS/C0348011	denotes	d to a Gene
T36498	62559-62569	UMLS/C0027971	denotes	, United S
T36499	62327-62333	UMLS/C0220909	denotes	rkin E
T36500	62327-62333	UMLS/C0220908	denotes	rkin E
T36501	62327-62333	UMLS/C1705053	denotes	rkin E
T36502	62239-62247	UMLS/C0012237	denotes	ith Pst1
T36503	62297-62300	UMLS/C1382104	denotes	ans
T36504	61926-61931	UP/P53502	denotes	mer-p
T36505	62327-62333	UMLS/C1305399	denotes	rkin E
T36506	61926-61931	UP/P53476	denotes	mer-p
T36507	62598-62603	UMLS/C0227391	denotes	Loui
T36508	61205-61208	UMLS/C0008115	denotes	RC
T36509	61385-61390	UMLS/C1879313	denotes	rief,
T36510	62205-62212	UMLS/C0008976	denotes	5 μg of
T36511	61796-61800	UMLS/C1442518	denotes	to
T36512	61945-61948	UMLS/C1442518	denotes	ied
T36513	62205-62212	UMLS/C0008972	denotes	5 μg of
T36514	62474-62482	UMLS/C1999177	denotes	hemilumi
T36515	61926-61931	UP/P60011	denotes	mer-p
T36516	62028-62034	UMLS/C1305356	denotes	AT, an
T36517	61809-61815	UMLS/C1511790	denotes	ecific
T36518	62501-62510	UMLS/C1511790	denotes	system (A
T36519	61926-61931	UP/P53500	denotes	mer-p
T36520	61796-61800	UMLS/C0001774	denotes	to
T36521	61945-61948	UMLS/C0001774	denotes	ied
T36522	61926-61931	UP/P68555	denotes	mer-p
T36523	61926-61931	UP/Q8SWN8	denotes	mer-p
T36524	62327-62333	UMLS/C1698960	denotes	rkin E
T36525	61562-61569	UMLS/C0185125	denotes	iosyste
T36526	61743-61750	UMLS/C0185125	denotes	iosyste
T36527	61950-61957	UMLS/C0185125	denotes	iosyste
T36528	62095-62102	UMLS/C0185125	denotes	iosyste
T36529	61498-61505	UMLS/C1555029	denotes	ranscri
T36530	62305-62316	UMLS/C1547239	denotes	d to a Gene
T36531	62159-62164	UMLS/C0023884	denotes	e exp
T36532	61926-61931	UP/P10989	denotes	mer-p
T36533	62191-62204	UMLS/C1148472	denotes	blot studies,
T36534	62159-62164	UMLS/C0023895	denotes	e exp
T36535	62223-62230	UMLS/C0017428	denotes	A was d
T36536	61796-61800	UMLS/C0036849	denotes	to
T36537	61945-61948	UMLS/C0036849	denotes	ied
T36538	61926-61931	UP/Q2U7A3	denotes	mer-p
T36539	62327-62333	UMLS/C0199230	denotes	rkin E
T36540	61796-61800	UMLS/C0542559	denotes	to
T36541	61945-61948	UMLS/C0542559	denotes	ied
T36542	62079-62085	UMLS/C0035804	denotes	imers
T36543	61724-61732	UMLS/C1610719	denotes	Detector
T36544	61926-61931	UP/P50138	denotes	mer-p
T36545	61926-61931	UP/P26183	denotes	mer-p
T36546	61926-61931	UP/P48465	denotes	mer-p
T36547	61926-61931	UP/P45521	denotes	mer-p
T36548	62305-62316	UMLS/C0728827	denotes	d to a Gene
T36549	61733-61741	UMLS/C0180392	denotes	(Applied
T36550	61693-61697	UMLS/C1706352	denotes	ents
T36551	61416-61429	UMLS/C0242694	denotes	oleus muscle,
T36552	62028-62034	UMLS/C0242694	denotes	AT, an
T36553	61857-61862	UMLS/C0039224	denotes	The
T36554	61774-61782	UMLS/C0205369	denotes	primer-p
T36555	61816-61824	UMLS/C0205369	denotes	gene exp
T36556	62205-62212	UMLS/C0557651	denotes	5 μg of
T36557	61926-61931	UP/O74258	denotes	mer-p
T36558	61926-61931	UP/P53499	denotes	mer-p
T36559	61724-61732	UMLS/C1519249	denotes	Detector
T36560	61863-61865	UMLS/C1179704	denotes	ri
T36561	61926-61931	UP/P90689	denotes	mer-p
T36562	62239-62247	UMLS/C0868946	denotes	ith Pst1
T36563	61724-61732	UMLS/C0004793	denotes	Detector
T36564	61926-61931	UP/P60009	denotes	mer-p
T36565	61017-61020	UMLS/C1325819	denotes	RNA
T36566	61054-61057	UMLS/C1325819	denotes	RNA
T36567	61398-61401	UMLS/C1325819	denotes	NA
T36568	61926-61931	UP/O65316	denotes	mer-p
T36569	62511-62517	UMLS/C1704459	denotes	ersham
T36570	61926-61931	UP/P45520	denotes	mer-p
T36571	61926-61931	UP/Q9UVZ8	denotes	mer-p
T36572	61062-61070	UMLS/C0205409	denotes	isolated
T36573	61402-61410	UMLS/C0205409	denotes	solated
T36574	61926-61931	UP/O16808	denotes	mer-p
T36575	62616-62624	UMLS/C0026222	denotes	United S
T36576	61926-61931	UP/O65315	denotes	mer-p
T36577	61926-61931	UP/P81085	denotes	mer-p
T36578	61926-61931	UP/O17320	denotes	mer-p
T36579	61022-61025	UMLS/C1325786	denotes	DNA
T36580	62231-62234	UMLS/C1325786	denotes	ges
T36581	61926-61931	UP/A5DQP9	denotes	mer-p
T36582	61440-61445	UMLS/C0018787	denotes	eart
T36583	62045-62050	UMLS/C0018787	denotes	e exp
T36584	61863-61865	UMLS/C1835435	denotes	ri
T36585	61595-61605	UMLS/C0006754	denotes	a, United
T36586	62360-62370	UMLS/C0006754	denotes	, United S
T36587	62511-62517	UMLS/C0449913	denotes	ersham
T36588	61926-61931	UMLS/C0439681	denotes	mer-p
T36589	61974-61982	UMLS/C1552866	denotes	in a sep
T36590	62641-62649	UMLS/C0487602	denotes	f the me
T36591	61926-61931	UP/Q24733	denotes	mer-p
T36592	61871-61878	UMLS/C0205435	denotes	or UCP-
T36593	62086-62093	UMLS/C0205435	denotes	Applied
T36594	61926-61931	UP/O65314	denotes	mer-p
T36595	61062-61070	UMLS/C0370215	denotes	isolated
T36596	61402-61410	UMLS/C0370215	denotes	solated
T36597	61841-61844	UMLS/C0006823	denotes	und
T36598	61582-61588	UMLS/C0344349	denotes	ty, Ca
T36599	62305-62316	UMLS/C1705822	denotes	d to a Gene
T36600	62511-62517	UMLS/C1553451	denotes	ersham
T36601	61926-61931	UP/P53491	denotes	mer-p
T36602	62483-62500	UMLS/C0162524	denotes	escence detection
T36603	61085-61091	UMLS/C0449851	denotes	method
T36604	61926-61931	UP/Q6TCF2	denotes	mer-p
T36605	61926-61931	UP/P53477	denotes	mer-p
T36606	61841-61844	UMLS/C0344312	denotes	und
T36607	61871-61878	UMLS/C1279901	denotes	or UCP-
T36608	62086-62093	UMLS/C1279901	denotes	Applied
T36609	61848-61853	UMLS/C0037088	denotes	Table
T36610	62067-62071	UMLS/C1511726	denotes	DH R
T36611	62181-62185	UMLS/C1511726	denotes	Sou
T36612	61926-61931	UP/Q75D00	denotes	mer-p
T36613	61926-61931	UP/P78711	denotes	mer-p
T36614	61926-61931	UP/P80709	denotes	mer-p
T36615	61926-61931	UP/Q99023	denotes	mer-p
T36616	61926-61931	UP/O00937	denotes	mer-p
T36617	61926-61931	UP/Q39758	denotes	mer-p
T36618	61724-61732	UMLS/C1553778	denotes	Detector
T36619	62132-62136	UMLS/C1692345	denotes	to
T36620	61048-61053	UMLS/C0439175	denotes	Total
T36621	61392-61397	UMLS/C0439175	denotes	otal
T36622	62205-62212	UMLS/C1705923	denotes	5 μg of
T36623	61926-61931	UP/P10365	denotes	mer-p
T36624	62400-62413	UMLS/C0028602	denotes	ion. Western
T36625	61385-61390	UMLS/C0453896	denotes	rief,
T36626	61926-61931	UP/Q8X119	denotes	mer-p
T36627	61039-61047	UMLS/C0936012	denotes	analyses
T36628	62641-62649	UMLS/C0038128	denotes	f the me
T36629	61530-61551	UMLS/C0035380	denotes	ranscription reagents
T36630	61623-61632	UMLS/C0443286	denotes	were per
T36631	61229-61234	UMLS/C1136188	denotes	ifts
T36632	61315-61319	UMLS/C1136188	denotes	ift
T36633	62014-62023	UMLS/C1882115	denotes	the sole
T36634	62145-62154	UMLS/C1882115	denotes	the live
T36635	61848-61853	UMLS/C0243095	denotes	Table
T36636	61809-61815	UMLS/C0442726	denotes	ecific
T36637	61926-61931	UMLS/C0001271	denotes	mer-p
T36638	61926-61931	UP/P60010	denotes	mer-p
T36639	61863-61865	UMLS/C1419027	denotes	ri
T36640	61595-61605	UMLS/C0324542	denotes	a, United
T36641	62360-62370	UMLS/C0324542	denotes	, United S
T36642	61926-61931	UP/P14235	denotes	mer-p
T36643	61974-61982	UMLS/C2700399	denotes	in a sep
T36644	61022-61025	UMLS/C0012854	denotes	DNA
T36645	62231-62234	UMLS/C0012854	denotes	ges
T36646	61774-61782	UMLS/C1552740	denotes	primer-p
T36647	61816-61824	UMLS/C1552740	denotes	gene exp
T36648	61988-61996	UMLS/C0443299	denotes	well and
T36649	61173-61182	UMLS/C1552738	denotes	described
T36650	61366-61375	UMLS/C1552738	denotes	escribed
T36651	61910-61919	UMLS/C1552738	denotes	[42]. Ac
T36652	62449-62458	UMLS/C1552738	denotes	[43] usin
T36653	61988-61996	UMLS/C1881713	denotes	well and
T36654	62400-62413	UMLS/C0020202	denotes	ion. Western
T36655	61926-61931	UP/P26182	denotes	mer-p
T36656	61926-61931	UP/P53498	denotes	mer-p
T36657	61926-61931	UP/P13363	denotes	mer-p
T36658	61342-61348	UMLS/C0599161	denotes	T-PCR
T36659	61926-61931	UP/P20904	denotes	mer-p
T36660	61127-61144	UMLS/C1621557	denotes	Northern blotting
T36661	61926-61931	UP/P51775	denotes	mer-p
T36662	61062-61070	UMLS/C1548221	denotes	isolated
T36663	61402-61410	UMLS/C1548221	denotes	solated
T36664	61693-61697	UMLS/C0008489	denotes	ents
T36665	61062-61070	UMLS/C1764827	denotes	isolated
T36666	61402-61410	UMLS/C1764827	denotes	solated
T36667	61974-61982	UMLS/C0332257	denotes	in a sep
T36668	62267-62282	UMLS/C0013855	denotes	resed on a 0.8%
T36669	61048-61053	UMLS/C0439810	denotes	Total
T36670	61392-61397	UMLS/C0439810	denotes	otal
T36671	61926-61931	UP/P91754	denotes	mer-p
T36672	61926-61931	UP/Q92192	denotes	mer-p
T36673	62327-62333	UMLS/C1710031	denotes	rkin E
T36674	61229-61234	UMLS/C0423899	denotes	ifts
T36675	61315-61319	UMLS/C0423899	denotes	ift
T36676	61926-61931	UP/Q11212	denotes	mer-p
T36677	61926-61931	UP/P11426	denotes	mer-p
T36678	61673-61679	UMLS/C1301627	denotes	ing Ta
T36679	61863-61865	UMLS/C0879262	denotes	ri
T36680	61926-61931	UP/P30161	denotes	mer-p
T36681	61304-61308	UMLS/C0006556	denotes	DNA
T36682	61926-61931	UP/P24902	denotes	mer-p
T36683	62327-62333	UMLS/C0430054	denotes	rkin E
T36684	62598-62603	UMLS/C1719918	denotes	Loui
T36685	61796-61800	UMLS/C1552685	denotes	to
T36686	61945-61948	UMLS/C1552685	denotes	ied
T36687	61623-61632	UMLS/C1114821	denotes	were per
T36688	62297-62300	UMLS/C0972569	denotes	ans
T36689	62159-62164	UMLS/C1278929	denotes	e exp
T37731	62779-62785	UMLS/C1705208	denotes	fibers
T37732	62981-62987	UMLS/C1705208	denotes	fibers
T37733	63287-63293	UMLS/C1705208	denotes	bers w
T37734	63728-63734	UMLS/C1705208	denotes	ers to
T37735	63868-63874	UMLS/C1705208	denotes	rs. St
T37736	63556-63561	UMLS/C0028814	denotes	an Op
T37737	63629-63634	UMLS/C0205112	denotes	al st
T37738	63530-63535	UMLS/C1704681	denotes	be (O
T37739	63549-63554	UMLS/C1704681	denotes	be, O
T37740	63837-63849	UP/P68099	denotes	chrome c to
T37741	63837-63849	UP/P00144	denotes	chrome c to
T37742	63544-63548	UMLS/C0049564	denotes	Y Pr
T37743	63827-63836	UMLS/C0205101	denotes	enous cyt
T37744	63837-63849	UP/P00048	denotes	chrome c to
T37745	63665-63668	UMLS/C0001459	denotes	-st
T37746	63743-63746	UMLS/C0001459	denotes	. T
T37747	63853-63856	UMLS/C0001459	denotes	sti
T37748	63530-63535	UMLS/C0182400	denotes	be (O
T37749	63549-63554	UMLS/C0182400	denotes	be, O
T37750	63837-63849	UP/P00072	denotes	chrome c to
T37751	62706-62713	UMLS/C0947630	denotes	studies
T37752	63635-63640	UMLS/C1442792	denotes	te 2
T37753	63681-63686	UMLS/C1442792	denotes	te 3
T37754	63876-63881	UMLS/C1442792	denotes	e 4 r
T37755	63579-63586	UMLS/C0016253	denotes	rida, U
T37756	63837-63849	UP/P00047	denotes	chrome c to
T37757	63141-63144	UMLS/C0001480	denotes	ATP
T37758	63837-63849	UP/P00071	denotes	chrome c to
T37759	63837-63849	UP/P99998	denotes	chrome c to
T37760	63837-63849	UP/P00035	denotes	chrome c to
T37761	63837-63849	UP/P15451	denotes	chrome c to
T37762	63837-63849	UP/Q4UEA0	denotes	chrome c to
T37763	63837-63849	UP/P00147	denotes	chrome c to
T37764	63191-63203	UMLS/C0242295	denotes	supplemented
T37765	63837-63849	UP/P00027	denotes	chrome c to
T37766	63141-63144	UMLS/C1705556	denotes	ATP
T37767	63494-63502	UMLS/C0444706	denotes	asured a
T37768	63024-63026	UMLS/C0319022	denotes	to
T37769	63735-63737	UMLS/C0319022	denotes	1
T37770	63850-63852	UMLS/C0319022	denotes	DP
T37771	63837-63849	UP/P67881	denotes	chrome c to
T37772	63837-63849	UP/P00069	denotes	chrome c to
T37773	63837-63849	UP/Q6IQM2	denotes	chrome c to
T37774	63837-63849	UP/P38091	denotes	chrome c to
T37775	63837-63849	UP/P68098	denotes	chrome c to
T37776	63837-63849	UP/Q52V08	denotes	chrome c to
T37777	63219-63226	UMLS/C0520481	denotes	aponin
T37778	63837-63849	UP/P00040	denotes	chrome c to
T37779	63837-63849	UP/P00057	denotes	chrome c to
T37780	63837-63849	UP/P00143	denotes	chrome c to
T37781	63837-63849	UP/P00029	denotes	chrome c to
T37782	63752-63761	UMLS/C1947912	denotes	egrity of
T37783	63093-63102	UMLS/C0020923	denotes	imidazole
T37784	63390-63399	UMLS/C0020923	denotes	idazole,
T37785	63093-63102	UMLS/C0020924	denotes	imidazole
T37786	63390-63399	UMLS/C0020924	denotes	idazole,
T37787	63837-63849	UP/P00020	denotes	chrome c to
T37788	63837-63849	UP/P18822	denotes	chrome c to
T37789	63837-63849	UP/P29380	denotes	chrome c to
T37790	63837-63849	UP/P62895	denotes	chrome c to
T37791	63837-63849	UP/O07091	denotes	chrome c to
T37792	63837-63849	UP/P00066	denotes	chrome c to
T37793	62744-62752	UMLS/C1516048	denotes	assessed
T37794	63802-63810	UMLS/C1516048	denotes	essed by
T37795	63837-63849	UP/O22642	denotes	chrome c to
T37796	62706-62713	UMLS/C1880229	denotes	studies
T37797	63719-63727	UMLS/C0332157	denotes	osing fi
T37798	63814-63820	UMLS/C1720086	denotes	ing 8
T37799	63837-63849	UMLS/C0653778	denotes	chrome c to
T37800	63837-63849	UP/Q41346	denotes	chrome c to
T37801	63837-63849	UP/P00061	denotes	chrome c to
T37802	63177-63180	UMLS/C0012789	denotes	DTT
T37803	63450-63453	UMLS/C0012789	denotes	T,
T37804	63837-63849	UP/P00148	denotes	chrome c to
T37805	63837-63849	UMLS/C0010754	denotes	chrome c to
T37806	63837-63849	UP/P62772	denotes	chrome c to
T37807	63837-63849	UMLS/C0010749	denotes	chrome c to
T37808	63837-63849	UP/P00142	denotes	chrome c to
T37809	63837-63849	UP/P53698	denotes	chrome c to
T37810	63837-63849	UP/P00076	denotes	chrome c to
T37811	63837-63849	UP/P68096	denotes	chrome c to
T37812	63837-63849	UP/P00003	denotes	chrome c to
T37813	63837-63849	UP/A8WQY3	denotes	chrome c to
T37814	63837-63849	UP/P00012	denotes	chrome c to
T37815	63837-63849	UP/P67882	denotes	chrome c to
T37816	63837-63849	UP/P00075	denotes	chrome c to
T37817	63837-63849	UP/P00056	denotes	chrome c to
T37818	63837-63849	UP/P00149	denotes	chrome c to
T37819	63562-63568	UMLS/C0015392	denotes	ics, D
T37820	63837-63849	UP/P62896	denotes	chrome c to
T37821	63837-63849	UP/P00046	denotes	chrome c to
T37822	63588-63601	UMLS/C0041703	denotes	ted States).
T37823	62791-62800	UMLS/C0038617	denotes	succinate
T37824	63012-63023	UMLS/C1299988	denotes	transferred
T37825	62993-63002	UMLS/C0086972	denotes	separated
T37826	63191-63203	UMLS/C1947943	denotes	supplemented
T37827	63837-63849	UP/P00052	denotes	chrome c to
T37828	63837-63849	UP/P00070	denotes	chrome c to
T37829	63837-63849	UP/P81459	denotes	chrome c to
T37830	64067-64084	UMLS/C0231832	denotes	on rates were exp
T37831	63837-63849	UP/P00078	denotes	chrome c to
T37832	63705-63715	UMLS/C0521095	denotes	ermined by
T37833	63012-63023	UMLS/C0040671	denotes	transferred
T37834	64090-64099	UMLS/C0017262	denotes	as nmol
T37835	63012-63023	UMLS/C1540850	denotes	transferred
T37836	63463-63466	UMLS/C1511233	denotes	A [
T37837	63971-63981	UMLS/C0037628	denotes	ility of o
T37838	63191-63203	UMLS/C1549514	denotes	supplemented
T37839	63837-63849	UP/Q7YR71	denotes	chrome c to
T37840	63837-63849	UP/P00077	denotes	chrome c to
T37841	63270-63276	UMLS/C0720654	denotes	ntle s
T37842	63837-63849	UP/P00032	denotes	chrome c to
T37843	63837-63849	UP/Q6Q4H8	denotes	chrome c to
T37844	62779-62785	UMLS/C1260603	denotes	fibers
T37845	62981-62987	UMLS/C1260603	denotes	fibers
T37846	63287-63293	UMLS/C1260603	denotes	bers w
T37847	63728-63734	UMLS/C1260603	denotes	ers to
T37848	63868-63874	UMLS/C1260603	denotes	rs. St
T37849	62825-62833	UMLS/C0392148	denotes	presence
T37850	63463-63466	UMLS/C0036774	denotes	A [
T37851	62706-62713	UMLS/C2349977	denotes	studies
T37852	63537-63543	UMLS/C2359957	denotes	gen FO
T37853	63985-63991	UMLS/C2359957	denotes	n in t
T37854	63837-63849	UP/Q52V10	denotes	chrome c to
T37855	64090-64099	UMLS/C1515670	denotes	as nmol
T37856	62837-62845	UMLS/C0035871	denotes	rotenone
T37857	63530-63535	UMLS/C0728863	denotes	be (O
T37858	63549-63554	UMLS/C0728863	denotes	be, O
T37859	63012-63023	UMLS/C1555583	denotes	transferred
T37860	63837-63849	UP/P00017	denotes	chrome c to
T37861	63837-63849	UP/P00151	denotes	chrome c to
T37862	62930-62945	UMLS/C0008161	denotes	chloral hydrate
T37863	63837-63849	UP/P19681	denotes	chrome c to
T37864	63837-63849	UP/P62894	denotes	chrome c to
T37865	62706-62713	UMLS/C2603343	denotes	studies
T37866	63837-63849	UP/P00036	denotes	chrome c to
T37867	64090-64099	UMLS/C1171362	denotes	as nmol
T37868	63837-63849	UP/P00018	denotes	chrome c to
T37869	63837-63849	UP/P00031	denotes	chrome c to
T37870	63182-63184	UMLS/C0450407	denotes	pH
T37871	63468-63470	UMLS/C0450407	denotes	7
T37872	63837-63849	UP/Q4SG99	denotes	chrome c to
T37873	63837-63849	UP/P00062	denotes	chrome c to
T37874	63182-63184	UMLS/C0450408	denotes	pH
T37875	63468-63470	UMLS/C0450408	denotes	7
T37876	63182-63184	UMLS/C0450409	denotes	pH
T37877	63468-63470	UMLS/C0450409	denotes	7
T37878	63837-63849	UP/P00138	denotes	chrome c to
T37879	62791-62800	UMLS/C0220918	denotes	succinate
T37880	63669-63679	UMLS/C1948023	denotes	mulated) s
T37881	63857-63867	UMLS/C1948023	denotes	ulated fib
T37882	63837-63849	UP/Q753F4	denotes	chrome c to
T37883	63012-63023	UMLS/C0348011	denotes	transferred
T37884	63837-63849	UP/P00053	denotes	chrome c to
T37885	63837-63849	UP/B4USV4	denotes	chrome c to
T37886	63182-63184	UMLS/C2363150	denotes	pH
T37887	63468-63470	UMLS/C2363150	denotes	7
T37888	63837-63849	UP/Q6WUX8	denotes	chrome c to
T37889	63182-63184	UMLS/C0031526	denotes	pH
T37890	63468-63470	UMLS/C0031526	denotes	7
T37891	62879-62884	UMLS/C1879313	denotes	brief
T37892	63463-63466	UMLS/C0005902	denotes	A [
T37893	63494-63502	UMLS/C0242485	denotes	asured a
T37894	63614-63625	UMLS/C0242485	denotes	surement of
T37895	62779-62785	UMLS/C0225326	denotes	fibers
T37896	62981-62987	UMLS/C0225326	denotes	fibers
T37897	63287-63293	UMLS/C0225326	denotes	bers w
T37898	63728-63734	UMLS/C0225326	denotes	ers to
T37899	63868-63874	UMLS/C0225326	denotes	rs. St
T37900	63814-63820	UMLS/C1524062	denotes	ing 8
T37901	62779-62785	UMLS/C1556142	denotes	fibers
T37902	62981-62987	UMLS/C1556142	denotes	fibers
T37903	63287-63293	UMLS/C1556142	denotes	bers w
T37904	63728-63734	UMLS/C1556142	denotes	ers to
T37905	63868-63874	UMLS/C1556142	denotes	rs. St
T37906	63944-63954	UMLS/C0028951	denotes	omycin (1
T37907	62706-62713	UMLS/C0008976	denotes	studies
T37908	62706-62713	UMLS/C0008972	denotes	studies
T37909	62804-62813	UMLS/C1710236	denotes	substrate
T37910	62772-62778	UMLS/C1305356	denotes	soleus
T37911	62974-62980	UMLS/C1305356	denotes	Soleus
T37912	63311-63316	UMLS/C1948050	denotes	ice f
T37913	62694-62705	UMLS/C1160636	denotes	respiration
T37914	62728-62739	UMLS/C1160636	denotes	respiration
T37915	63478-63489	UMLS/C1160636	denotes	spiration w
T37916	63643-63654	UMLS/C1160636	denotes	piration, m
T37917	63689-63700	UMLS/C1160636	denotes	piration wa
T37918	63884-63895	UMLS/C1160636	denotes	iration (un
T37919	63999-64010	UMLS/C1160636	denotes	ration buff
T37920	63012-63023	UMLS/C1547239	denotes	transferred
T37921	62779-62785	UMLS/C1304649	denotes	fibers
T37922	62981-62987	UMLS/C1304649	denotes	fibers
T37923	63287-63293	UMLS/C1304649	denotes	bers w
T37924	63728-63734	UMLS/C1304649	denotes	ers to
T37925	63868-63874	UMLS/C1304649	denotes	rs. St
T37926	63837-63849	UP/P59218	denotes	chrome c to
T37927	63912-63921	UMLS/C0220825	denotes	uated fol
T37928	63837-63849	UP/P00028	denotes	chrome c to
T37929	63837-63849	UP/P00054	denotes	chrome c to
T37930	63837-63849	UP/P00039	denotes	chrome c to
T37931	63837-63849	UP/P00043	denotes	chrome c to
T37932	63837-63849	UP/P68097	denotes	chrome c to
T37933	63837-63849	UP/P00038	denotes	chrome c to
T37934	63311-63316	UMLS/C1720725	denotes	ice f
T37935	63182-63184	UMLS/C1304686	denotes	pH
T37936	63468-63470	UMLS/C1304686	denotes	7
T37937	63665-63668	UMLS/C1428806	denotes	-st
T37938	63743-63746	UMLS/C1428806	denotes	. T
T37939	63853-63856	UMLS/C1428806	denotes	sti
T37940	63494-63502	UMLS/C1879489	denotes	asured a
T37941	63249-63255	UMLS/C1442458	denotes	0 min
T37942	63125-63132	UMLS/C0039350	denotes	taurine
T37943	63421-63428	UMLS/C0039350	denotes	urine,
T37944	63556-63561	UMLS/C0282279	denotes	an Op
T37945	63304-63310	UMLS/C1548982	denotes	shed t
T37946	63837-63849	UP/P22342	denotes	chrome c to
T37947	63837-63849	UP/P00073	denotes	chrome c to
T37948	63012-63023	UMLS/C0728827	denotes	transferred
T37949	62694-62705	UMLS/C0035203	denotes	respiration
T37950	62728-62739	UMLS/C0035203	denotes	respiration
T37951	63478-63489	UMLS/C0035203	denotes	spiration w
T37952	63643-63654	UMLS/C0035203	denotes	piration, m
T37953	63689-63700	UMLS/C0035203	denotes	piration wa
T37954	63884-63895	UMLS/C0035203	denotes	iration (un
T37955	63999-64010	UMLS/C0035203	denotes	ration buff
T37956	62895-62901	UMLS/C0086287	denotes	female
T37957	63837-63849	UP/P00145	denotes	chrome c to
T37958	62772-62778	UMLS/C0242694	denotes	soleus
T37959	62974-62980	UMLS/C0242694	denotes	Soleus
T37960	64032-64037	UMLS/C1883727	denotes	as 24
T37961	63837-63849	UP/P19974	denotes	chrome c to
T37962	63522-63529	UMLS/C0029144	denotes	ical pr
T37963	63562-63568	UMLS/C0029144	denotes	ics, D
T37964	63321-63327	UMLS/C0456692	denotes	min e
T37965	63182-63184	UMLS/C0020283	denotes	pH
T37966	63468-63470	UMLS/C0020283	denotes	7
T37967	62706-62713	UMLS/C0557651	denotes	studies
T37968	63814-63820	UMLS/C1883712	denotes	ing 8
T37969	63932-63940	UMLS/C1883712	denotes	tion of
T37970	63530-63535	UMLS/C0419358	denotes	be (O
T37971	63549-63554	UMLS/C0419358	denotes	be, O
T37972	62895-62901	UMLS/C0015780	denotes	female
T37973	63219-63226	UMLS/C0036189	denotes	aponin
T37974	63249-63255	UMLS/C0456693	denotes	0 min
T37975	62825-62833	UMLS/C0150312	denotes	presence
T37976	63537-63543	UMLS/C1547125	denotes	gen FO
T37977	63985-63991	UMLS/C1547125	denotes	n in t
T37978	63562-63568	UMLS/C0334946	denotes	ics, D
T37979	63494-63502	UMLS/C0079809	denotes	asured a
T37980	62694-62705	UMLS/C0282636	denotes	respiration
T37981	62728-62739	UMLS/C0282636	denotes	respiration
T37982	63478-63489	UMLS/C0282636	denotes	spiration w
T37983	63643-63654	UMLS/C0282636	denotes	piration, m
T37984	63689-63700	UMLS/C0282636	denotes	piration wa
T37985	63884-63895	UMLS/C0282636	denotes	iration (un
T37986	63999-64010	UMLS/C0282636	denotes	ration buff
T37987	62680-62693	UMLS/C0026237	denotes	Mitochondrial
T37988	62714-62727	UMLS/C0026237	denotes	Mitochondrial
T37989	63837-63849	UP/P99999	denotes	chrome c to
T37990	63837-63849	UP/P00059	denotes	chrome c to
T37991	63837-63849	UP/P68519	denotes	chrome c to
T37992	63837-63849	UP/Q5RFH4	denotes	chrome c to
T37993	63837-63849	UP/P00049	denotes	chrome c to
T37994	64032-64037	UMLS/C1515187	denotes	as 24
T37995	63837-63849	UP/Q6QLW4	denotes	chrome c to
T37996	63837-63849	UP/P00042	denotes	chrome c to
T37997	63837-63849	UP/Q4N594	denotes	chrome c to
T37998	63635-63640	UMLS/C1301808	denotes	te 2
T37999	63681-63686	UMLS/C1301808	denotes	te 3
T38000	63876-63881	UMLS/C1301808	denotes	e 4 r
T38001	63562-63568	UMLS/C0260077	denotes	ics, D
T38002	63604-63613	UMLS/C1719822	denotes	lowing me
T38003	63922-63931	UMLS/C1719822	denotes	owing add
T38004	62680-62693	UMLS/C0521451	denotes	Mitochondrial
T38005	62714-62727	UMLS/C0521451	denotes	Mitochondrial
T38006	63837-63849	UP/P00021	denotes	chrome c to
T38007	63012-63023	UMLS/C1705822	denotes	transferred
T38008	63837-63849	UP/P00064	denotes	chrome c to
T38009	63837-63849	UP/Q6C9Q0	denotes	chrome c to
T38010	63837-63849	UP/P00022	denotes	chrome c to
T38011	63837-63849	UP/P00058	denotes	chrome c to
T38012	63537-63543	UMLS/C0030054	denotes	gen FO
T38013	63985-63991	UMLS/C0030054	denotes	n in t
T38014	64053-64055	UMLS/C0030054	denotes	l−
T38015	64108-64110	UMLS/C0030054	denotes	1
T38016	63837-63849	UP/O93863	denotes	chrome c to
T38017	62779-62785	UMLS/C0012173	denotes	fibers
T38018	62981-62987	UMLS/C0012173	denotes	fibers
T38019	63287-63293	UMLS/C0012173	denotes	bers w
T38020	63728-63734	UMLS/C0012173	denotes	ers to
T38021	63868-63874	UMLS/C0012173	denotes	rs. St
T38022	63837-63849	UP/P00079	denotes	chrome c to
T38023	63837-63849	UP/P32556	denotes	chrome c to
T38024	63837-63849	UP/P00004	denotes	chrome c to
T38025	63837-63849	UP/P68100	denotes	chrome c to
T38026	63837-63849	UP/P68518	denotes	chrome c to
T38027	63837-63849	UP/P62773	denotes	chrome c to
T38028	63837-63849	UP/O13393	denotes	chrome c to
T38029	63463-63466	UMLS/C0487992	denotes	A [
T38030	63029-63035	UMLS/C0006353	denotes	buffer
T38031	64011-64017	UMLS/C0006353	denotes	r at 2
T38032	63837-63849	UP/Q9RQB9	denotes	chrome c to
T38033	63837-63849	UP/P00067	denotes	chrome c to
T38034	63837-63849	UP/P00152	denotes	chrome c to
T38035	63530-63535	UMLS/C2347609	denotes	be (O
T38036	63549-63554	UMLS/C2347609	denotes	be, O
T38037	63837-63849	UP/P00013	denotes	chrome c to
T38038	62706-62713	UMLS/C1705923	denotes	studies
T38039	63837-63849	UP/P00060	denotes	chrome c to
T38040	63827-63836	UMLS/C0205228	denotes	enous cyt
T38041	62879-62884	UMLS/C0453896	denotes	brief
T38042	62779-62785	UMLS/C0304068	denotes	fibers
T38043	62981-62987	UMLS/C0304068	denotes	fibers
T38044	63287-63293	UMLS/C0304068	denotes	bers w
T38045	63728-63734	UMLS/C0304068	denotes	ers to
T38046	63868-63874	UMLS/C0304068	denotes	rs. St
T38047	63837-63849	UP/Q96VP3	denotes	chrome c to
T38048	63837-63849	UP/P81280	denotes	chrome c to
T38049	63837-63849	UP/P00025	denotes	chrome c to
T38050	63837-63849	UP/P00068	denotes	chrome c to
T38051	63837-63849	UP/P00024	denotes	chrome c to
T38052	63769-63797	UMLS/C0230839	denotes	er mitochondrial membrane wa
T38053	63530-63535	UMLS/C1442917	denotes	be (O
T38054	63549-63554	UMLS/C1442917	denotes	be, O
T38055	63635-63640	UMLS/C1552743	denotes	te 2
T38056	63681-63686	UMLS/C1552743	denotes	te 3
T38057	63876-63881	UMLS/C1552743	denotes	e 4 r
T38058	63837-63849	UMLS/C1153524	denotes	chrome c to
T38059	62993-63002	UMLS/C0443299	denotes	separated
T38060	64048-64052	UMLS/C0439191	denotes	2 ·
T38061	64103-64107	UMLS/C0439191	denotes	min
T38062	62860-62869	UMLS/C1552738	denotes	described
T38063	62993-63002	UMLS/C1881713	denotes	separated
T38064	63837-63849	UP/P00008	denotes	chrome c to
T38065	63752-63761	UMLS/C0205266	denotes	egrity of
T38066	63837-63849	UP/P21665	denotes	chrome c to
T38067	63837-63849	UP/P00065	denotes	chrome c to
T38068	63837-63849	UP/Q869N1	denotes	chrome c to
T38069	63604-63613	UMLS/C0332282	denotes	lowing me
T38070	63922-63931	UMLS/C0332282	denotes	owing add
T38071	63837-63849	UP/P00014	denotes	chrome c to
T38072	63463-63466	UP/P02769	denotes	A [
T38073	63837-63849	UP/P00037	denotes	chrome c to
T38074	63665-63668	UMLS/C0004374	denotes	-st
T38075	63743-63746	UMLS/C0004374	denotes	. T
T38076	63853-63856	UMLS/C0004374	denotes	sti
T38077	63604-63613	UMLS/C0332283	denotes	lowing me
T38078	63922-63931	UMLS/C0332283	denotes	owing add
T38079	63837-63849	UP/A2Y4S9	denotes	chrome c to
T38080	63837-63849	UP/Q4HVX7	denotes	chrome c to
T38081	62951-62971	UMLS/C0560741	denotes	mg/kg of body weight
T38082	63837-63849	UP/P00019	denotes	chrome c to
T38083	63656-63663	UMLS/C0205289	denotes	imal (A
T38084	63277-63285	UMLS/C1883171	denotes	irring.
T38085	63837-63849	UP/P00011	denotes	chrome c to
T38086	63837-63849	UP/P00063	denotes	chrome c to
T38087	62912-62924	UMLS/C1720436	denotes	anesthetized
T38088	63837-63849	UP/P00051	denotes	chrome c to
T38089	63837-63849	UP/P00146	denotes	chrome c to
T38090	63837-63849	UP/P00041	denotes	chrome c to
T38091	63080-63085	UMLS/C0024472	denotes	MgCl2
T38092	63377-63382	UMLS/C0024472	denotes	Cl2,
T38093	63141-63144	UMLS/C1366832	denotes	ATP
T38094	63837-63849	UP/P00154	denotes	chrome c to
T38095	63837-63849	UP/P00153	denotes	chrome c to
T38096	63191-63203	UMLS/C2348609	denotes	supplemented
T38097	63837-63849	UP/P00074	denotes	chrome c to
T38098	62895-62901	UMLS/C1705497	denotes	female
T38099	63837-63849	UP/P25400	denotes	chrome c to
T38100	63837-63849	UP/P12831	denotes	chrome c to
T38101	62895-62901	UMLS/C1705498	denotes	female
T38102	63837-63849	UP/Q0DI31	denotes	chrome c to
T38103	63837-63849	UP/P00002	denotes	chrome c to
T38104	63837-63849	UP/Q52V09	denotes	chrome c to
T38105	63837-63849	UP/P00030	denotes	chrome c to
T38106	63837-63849	UP/P56205	denotes	chrome c to
T38107	63837-63849	UP/P00007	denotes	chrome c to
T38108	63837-63849	UP/P68517	denotes	chrome c to
T38839	64299-64306	UMLS/C1705923	denotes	studies
T38768	64121-64128	UP/P12704	denotes	Insulin
T38769	64384-64392	UMLS/C1514756	denotes	received
T38770	64227-64235	UMLS/C0332152	denotes	Prior to
T38771	64121-64128	UP/Q91XI3	denotes	Insulin
T38772	64121-64128	UP/P68243	denotes	Insulin
T38773	64121-64128	UP/P01336	denotes	Insulin
T38774	64236-64243	UMLS/C1880229	denotes	studies
T38775	64299-64306	UMLS/C1880229	denotes	studies
T38776	64121-64128	UP/Q8HXV2	denotes	Insulin
T38777	64121-64128	UP/P01317	denotes	Insulin
T38778	64121-64128	UP/Q9NDE7	denotes	Insulin
T38779	64121-64128	UP/P01324	denotes	Insulin
T38780	64469-64482	UMLS/C0041703	denotes	United States
T38781	64121-64128	UP/P09476	denotes	Insulin
T38782	64121-64128	UP/P01316	denotes	Insulin
T38783	64532-64545	UMLS/C0005802	denotes	blood glucose
T38784	64502-64510	UMLS/C1300561	denotes	units/kg
T38785	64338-64346	UMLS/C2699488	denotes	solution
T38786	64384-64392	UMLS/C1709850	denotes	received
T38787	64654-64660	UMLS/C0038995	denotes	Sweden
T38788	64121-64128	UMLS/C1337112	denotes	Insulin
T38789	64121-64128	UP/P01308	denotes	Insulin
T38790	64121-64128	UP/P30406	denotes	Insulin
T38791	64550-64560	UMLS/C0521095	denotes	determined
T38792	64121-64128	UP/P01333	denotes	Insulin
T38794	64169-64192	UMLS/C0236287	denotes	Insulin tolerance tests
T38795	64121-64128	UP/P01328	denotes	Insulin
T38796	64121-64128	UP/P30407	denotes	Insulin
T38797	64318-64326	UMLS/C1720154	denotes	injected
T38798	64255-64261	UMLS/C0456962	denotes	fasted
T38799	64121-64128	UP/P04667	denotes	Insulin
T38800	64121-64128	UP/P01310	denotes	Insulin
T38801	64121-64128	UP/P67972	denotes	Insulin
T38802	64121-64128	UP/P29335	denotes	Insulin
T38803	64350-64359	UMLS/C0017725	denotes	D-glucose
T38804	64121-64128	UP/P68988	denotes	Insulin
T38805	64236-64243	UMLS/C0947630	denotes	studies
T38806	64299-64306	UMLS/C0947630	denotes	studies
T38807	64236-64243	UMLS/C0557651	denotes	studies
T38808	64299-64306	UMLS/C0557651	denotes	studies
T38809	64121-64128	UP/P01318	denotes	Insulin
T38810	64121-64128	UP/Q62587	denotes	Insulin
T38811	64133-64156	UMLS/C0017741	denotes	glucose tolerance tests
T38812	64121-64128	UP/P12708	denotes	Insulin
T38813	64121-64128	UP/P81881	denotes	Insulin
T38814	64121-64128	UP/P68991	denotes	Insulin
T38815	64121-64128	UP/P01321	denotes	Insulin
T38816	64396-64408	UMLS/C0021493	denotes	IP injection
T38817	64121-64128	UP/Q9TQY7	denotes	Insulin
T38818	64262-64271	UMLS/C0439583	denotes	overnight
T38819	64121-64128	UMLS/C0202098	denotes	Insulin
T38820	64121-64128	UP/P01342	denotes	Insulin
T38821	64121-64128	UP/O73727	denotes	Insulin
T38822	64121-64128	UP/P51463	denotes	Insulin
T38823	64121-64128	UP/P69045	denotes	Insulin
T38824	64121-64128	UP/P01340	denotes	Insulin
T38825	64121-64128	UP/P01314	denotes	Insulin
T38826	64121-64128	UP/P68245	denotes	Insulin
T38827	64198-64207	UMLS/C1550369	denotes	performed
T38828	64121-64128	UP/P01339	denotes	Insulin
T38829	64593-64602	UMLS/C0798503	denotes	challenge
T38830	64121-64128	UP/P09477	denotes	Insulin
T38831	64133-64156	UMLS/C1260606	denotes	glucose tolerance tests
T38832	64121-64128	UP/P01311	denotes	Insulin
T38833	64121-64128	UP/P01335	denotes	Insulin
T38834	64338-64346	UMLS/C0037633	denotes	solution
T38835	64121-64128	UP/Q6YK33	denotes	Insulin
T38836	64121-64128	UP/P67974	denotes	Insulin
T38837	64121-64128	UP/P12703	denotes	Insulin
T38838	64236-64243	UMLS/C1705923	denotes	studies
T38840	64121-64128	UP/P17715	denotes	Insulin
T38841	64121-64128	UP/P01319	denotes	Insulin
T38842	64489-64493	UMLS/C0869039	denotes	dose
T38843	64121-64128	UP/P01331	denotes	Insulin
T38844	64198-64207	UMLS/C0884358	denotes	performed
T38845	64236-64243	UMLS/C2349977	denotes	studies
T38846	64299-64306	UMLS/C2349977	denotes	studies
T38847	64121-64128	UP/P67970	denotes	Insulin
T38848	64121-64128	UP/P81025	denotes	Insulin
T38849	64236-64243	UMLS/C2603343	denotes	studies
T38850	64299-64306	UMLS/C2603343	denotes	studies
T38851	64338-64346	UMLS/C0525069	denotes	solution
T38852	64587-64592	UMLS/C0687676	denotes	after
T38853	64412-64417	UMLS/C0020156	denotes	human
T38854	64273-64276	UMLS/C1135868	denotes	GTT
T38855	64295-64298	UMLS/C1135868	denotes	GTT
T38856	64121-64128	UP/P67968	denotes	Insulin
T38857	64121-64128	UP/P81423	denotes	Insulin
T38858	64508-64525	UMLS/C1508277	denotes	kg of body weight
T38859	64121-64128	UP/P07453	denotes	Insulin
T38860	64121-64128	UP/P12705	denotes	Insulin
T38861	64121-64128	UP/P06306	denotes	Insulin
T38862	64121-64128	UP/P01320	denotes	Insulin
T38863	64489-64493	UMLS/C1114758	denotes	dose
T38864	64255-64261	UMLS/C1550565	denotes	fasted
T38865	64121-64128	UP/P13190	denotes	Insulin
T38866	64121-64128	UP/P68989	denotes	Insulin
T38867	64121-64128	UP/Q9W7R2	denotes	Insulin
T38868	64121-64128	UP/P01329	denotes	Insulin
T38869	64121-64128	UP/P69048	denotes	Insulin
T38870	64338-64346	UMLS/C1382100	denotes	solution
T38871	64583-64586	UMLS/C0702093	denotes	min
T38872	64460-64467	UMLS/C0021206	denotes	Indiana
T38873	64121-64128	UP/P01330	denotes	Insulin
T38874	64211-64220	UMLS/C1552738	denotes	described
T38875	64121-64128	UMLS/C1145751	denotes	Insulin
T38876	64583-64586	UMLS/C0439232	denotes	min
T38877	64236-64243	UMLS/C0008976	denotes	studies
T38878	64299-64306	UMLS/C0008976	denotes	studies
T38879	64527-64531	UMLS/C0039259	denotes	Tail
T38880	64121-64128	UP/P01313	denotes	Insulin
T38881	64121-64128	UP/P69047	denotes	Insulin
T38882	64236-64243	UMLS/C0008972	denotes	studies
T38883	64299-64306	UMLS/C0008972	denotes	studies
T38884	64121-64128	UP/P41522	denotes	Insulin
T38885	64121-64128	UMLS/C0021641	denotes	Insulin
T38886	64418-64433	UMLS/C0021641	denotes	regular insulin
T38887	64121-64128	UP/P30410	denotes	Insulin
T38888	64121-64128	UP/Q98TA8	denotes	Insulin
T38889	64121-64128	UP/P68992	denotes	Insulin
T38890	64121-64128	UP/P21563	denotes	Insulin
T38891	64121-64128	UP/P67973	denotes	Insulin
T38892	64121-64128	UP/P69046	denotes	Insulin
T38893	64121-64128	UP/P0C236	denotes	Insulin
T38894	64121-64128	UP/P67969	denotes	Insulin
T38895	64121-64128	UP/P68987	denotes	Insulin
T38896	64621-64629	UMLS/C1706246	denotes	Analyzer
T38897	64587-64592	UMLS/C0231290	denotes	after
T38898	64489-64493	UMLS/C0178602	denotes	dose
T38899	64121-64128	UMLS/C1533581	denotes	Insulin
T38900	64121-64128	UP/P42633	denotes	Insulin
T38901	64121-64128	UP/P01334	denotes	Insulin
T38902	64583-64586	UMLS/C1552937	denotes	min
T38903	64121-64128	UMLS/C1579433	denotes	Insulin
T38904	64593-64602	UMLS/C0805586	denotes	challenge
T38905	64157-64176	UMLS/C1719133	denotes	Glucose and Insulin
T38906	64121-64128	UP/P01327	denotes	Insulin
T38907	64621-64629	UMLS/C0179038	denotes	Analyzer
T38908	64121-64128	UP/P01315	denotes	Insulin
T38909	64121-64128	UP/P18109	denotes	Insulin
T38910	64255-64261	UMLS/C0015663	denotes	fasted
T38911	64121-64128	UP/P68990	denotes	Insulin
T39247	64704-64709	UMLS/C0871208	denotes	rates
T39248	64834-64839	UMLS/C0871208	denotes	rates
T39249	65023-65033	UMLS/C0679207	denotes	sessment o
T39250	64728-64734	UMLS/C0086287	denotes	female
T39251	64968-64976	UMLS/C1720154	denotes	njected
T39252	64893-64904	UMLS/C1292856	denotes	timulation
T39253	64905-64912	UMLS/C1705923	denotes	tudies,
T39254	64905-64912	UMLS/C0947630	denotes	tudies,
T39255	64905-64912	UMLS/C0557651	denotes	tudies,
T39256	64905-64912	UMLS/C2349977	denotes	tudies,
T39257	64905-64912	UMLS/C2603343	denotes	tudies,
T39258	64728-64734	UMLS/C0015780	denotes	female
T39259	64704-64709	UMLS/C1521828	denotes	rates
T39260	64834-64839	UMLS/C1521828	denotes	rates
T39261	64893-64904	UMLS/C1948023	denotes	timulation
T39262	64790-64796	UMLS/C1704459	denotes	System
T39263	64745-64753	UMLS/C0444706	denotes	measured
T39264	64771-64782	UMLS/C0348000	denotes	Instruments
T39265	64704-64709	UMLS/C1549480	denotes	rates
T39266	64834-64839	UMLS/C1549480	denotes	rates
T39267	64925-64930	UMLS/C0227391	denotes	igma)
T39268	64745-64753	UMLS/C0079809	denotes	measured
T39269	64745-64753	UMLS/C0242485	denotes	measured
T39270	65076-65086	UMLS/C1524062	denotes	ditional 1
T39271	64992-65003	UMLS/C0005910	denotes	dy weight)
T39272	64905-64912	UMLS/C0008976	denotes	tudies,
T39273	64905-64912	UMLS/C0008972	denotes	tudies,
T39274	64949-64956	UMLS/C0232920	denotes	terile
T39275	64992-65003	UMLS/C0944911	denotes	dy weight)
T39276	64845-64853	UMLS/C1516048	denotes	assessed
T39277	65023-65033	UMLS/C1516048	denotes	sessment o
T39278	64905-64912	UMLS/C1880229	denotes	tudies,
T39279	65060-65068	UMLS/C1553414	denotes	corded f
T39280	64790-64796	UMLS/C0449913	denotes	System
T39281	64936-64945	UMLS/C1549535	denotes	issolved
T39282	65060-65068	UMLS/C1548330	denotes	corded f
T39283	64798-64805	UMLS/C1622327	denotes	Resting
T39284	65060-65068	UMLS/C0034869	denotes	corded f
T39285	65023-65033	UMLS/C1261322	denotes	sessment o
T39286	64798-64805	UMLS/C0450239	denotes	Resting
T39287	64806-64814	UMLS/C1442488	denotes	baseline
T39288	64992-65003	UMLS/C1305866	denotes	dy weight)
T39289	64949-64956	UMLS/C0678108	denotes	terile
T39290	64806-64814	UMLS/C1552824	denotes	baseline
T39291	64914-64923	UMLS/C0054075	denotes	RL 37344
T39292	65023-65033	UMLS/C0031809	denotes	sessment o
T39293	64790-64796	UMLS/C1553451	denotes	System
T39294	64798-64805	UMLS/C0035253	denotes	Resting
T39295	64806-64814	UMLS/C0168634	denotes	baseline
T39296	64957-64963	UMLS/C0036082	denotes	aline
T39297	65104-65113	UMLS/C1516695	denotes	llected a
T39298	65060-65068	UMLS/C2355580	denotes	corded f
T39299	64745-64753	UMLS/C1879489	denotes	measured
T39300	64685-64703	UMLS/C0030055	denotes	Oxygen consumption
T39301	64815-64833	UMLS/C0030055	denotes	oxygen consumption
T39302	65037-65055	UMLS/C0030055	denotes	ygen consumption w
T39303	64728-64734	UMLS/C1705497	denotes	female
T39304	64728-64734	UMLS/C1705498	denotes	female
T39305	65060-65068	UMLS/C0557033	denotes	corded f
T39306	64925-64930	UMLS/C1719918	denotes	igma)
T39307	64664-64684	UMLS/C0006781	denotes	Indirect calorimetry
T39308	65099-65103	UMLS/C1511726	denotes	ta c
T39309	65104-65113	UMLS/C1516698	denotes	llected a
T39795	65432-65441	UMLS/C1552923	denotes	sectioned
T39796	65918-65926	UMLS/C1552923	denotes	ections
T39797	66091-66099	UMLS/C1552923	denotes	ections
T39798	66258-66266	UMLS/C1552923	denotes	ctions w
T39799	65432-65441	UMLS/C1552924	denotes	sectioned
T39800	65918-65926	UMLS/C1552924	denotes	ections
T39801	66091-66099	UMLS/C1552924	denotes	ections
T39802	66258-66266	UMLS/C1552924	denotes	ctions w
T39803	66190-66204	UMLS/C1446561	denotes	oncentrations
T39804	65479-65494	UMLS/C0242692	denotes	skeletal muscle
T39805	65421-65426	UMLS/C0035191	denotes	resin
T39806	65745-65749	UMLS/C1704970	denotes	ean
T39807	65638-65647	UMLS/C1705242	denotes	different
T39808	65173-65186	UMLS/C0242694	denotes	Soleus muscle
T39809	66014-66021	UMLS/C0008857	denotes	itrate
T39810	65216-65221	UMLS/C0599992	denotes	fixed
T39811	65942-65945	UMLS/C1883724	denotes	ut
T39812	65951-65958	UMLS/C0950318	denotes	ormvar-
T39813	65959-65965	UMLS/C0999543	denotes	oated
T39814	65745-65749	UMLS/C2347634	denotes	ean
T39815	66137-66146	UMLS/C1306665	denotes	rainstem,
T39816	65977-65984	UMLS/C1704680	denotes	tained
T39817	66081-66089	UMLS/C1704680	denotes	taining,
T39818	65413-65420	UMLS/C0678558	denotes	plastic
T39819	65315-65322	UMLS/C1547928	denotes	tissues
T39820	65858-65864	UMLS/C1547928	denotes	issue
T39821	65851-65856	UMLS/C0006104	denotes	rain,
T39822	66103-66108	UMLS/C0006104	denotes	rain,
T39823	65959-65965	UMLS/C0325028	denotes	oated
T39824	66026-66034	UMLS/C0332128	denotes	xamined
T39825	66232-66240	UMLS/C0030415	denotes	araffin
T39826	65222-65231	UMLS/C0439583	denotes	overnight
T39827	65139-65148	UMLS/C1552405	denotes	Histology
T39828	65479-65494	UMLS/C1550659	denotes	skeletal muscle
T39829	65383-65390	UMLS/C0001962	denotes	ethanol
T39830	66208-66215	UMLS/C0001962	denotes	lcohol
T39831	65959-65965	UMLS/C1522408	denotes	oated
T39832	65432-65441	UMLS/C1705191	denotes	sectioned
T39833	65918-65926	UMLS/C1705191	denotes	ections
T39834	66091-66099	UMLS/C1705191	denotes	ections
T39835	66258-66266	UMLS/C1705191	denotes	ctions w
T39836	65851-65856	UMLS/C1269537	denotes	rain,
T39837	66103-66108	UMLS/C1269537	denotes	rain,
T39838	65216-65221	UMLS/C1522662	denotes	fixed
T39839	66137-66146	UMLS/C0006121	denotes	rainstem,
T39840	65409-65412	UMLS/C1547114	denotes	Bed
T39841	66208-66215	UMLS/C0001975	denotes	lcohol
T39842	66208-66215	UMLS/C0001973	denotes	lcohol
T39843	65413-65420	UMLS/C0032167	denotes	plastic
T39844	65930-65936	UMLS/C1176472	denotes	ortex
T39845	66152-66162	UMLS/C1268981	denotes	erebellum,
T39846	65495-65508	UMLS/C0026237	denotes	mitochondrial
T39847	65768-65780	UMLS/C0026237	denotes	itochondria
T39848	65467-65474	UMLS/C0018787	denotes	Cardiac
T39849	65238-65252	UMLS/C0017814	denotes	glutaraldehyde
T39850	65526-65532	UMLS/C2700258	denotes	volume
T39851	65750-65756	UMLS/C2700258	denotes	olume
T39852	65851-65856	UMLS/C0006111	denotes	rain,
T39853	66103-66108	UMLS/C0006111	denotes	rain,
T39854	65784-65794	UMLS/C0027075	denotes	yofibrils
T39855	66009-66013	UMLS/C2348269	denotes	ead
T39856	65216-65221	UMLS/C0231441	denotes	fixed
T39857	66009-66013	UMLS/C0332152	denotes	ead
T39858	65624-65630	UMLS/C0003062	denotes	animal
T39859	65432-65441	UMLS/C1552858	denotes	sectioned
T39860	65918-65926	UMLS/C1552858	denotes	ections
T39861	66091-66099	UMLS/C1552858	denotes	ections
T39862	66258-66266	UMLS/C1552858	denotes	ctions w
T39863	65526-65532	UMLS/C1690016	denotes	volume
T39864	65750-65756	UMLS/C1690016	denotes	olume
T39865	65153-65172	UMLS/C0026019	denotes	electron microscopy
T39866	65446-65465	UMLS/C0026019	denotes	electron microscopy
T39867	66110-66119	UMLS/C1552866	denotes	ncluding
T39868	65977-65984	UMLS/C0487602	denotes	tained
T39869	66081-66089	UMLS/C0487602	denotes	taining,
T39870	65835-65843	UMLS/C1524024	denotes	nalysis
T39871	65432-65441	UMLS/C0205155	denotes	sectioned
T39872	65918-65926	UMLS/C0205155	denotes	ections
T39873	66091-66099	UMLS/C0205155	denotes	ections
T39874	66258-66266	UMLS/C0205155	denotes	ctions w
T39875	65495-65508	UMLS/C0521451	denotes	mitochondrial
T39876	65216-65221	UMLS/C0443218	denotes	fixed
T39877	65139-65148	UMLS/C0205462	denotes	Histology
T39878	65383-65390	UMLS/C0202304	denotes	ethanol
T39879	66208-66215	UMLS/C0202304	denotes	lcohol
T39880	65990-66004	UMLS/C0077854	denotes	ranyl acetate
T39881	65632-65637	UMLS/C0205449	denotes	three
T39882	65392-65400	UMLS/C1707903	denotes	embedded
T39883	66220-66228	UMLS/C1707903	denotes	mbedded
T39884	65930-65936	UMLS/C0001614	denotes	ortex
T39885	66208-66215	UMLS/C0337678	denotes	lcohol
T39886	65376-65382	UMLS/C0919553	denotes	graded
T39887	66183-66189	UMLS/C0919553	denotes	raded
T39888	65432-65441	UMLS/C1522472	denotes	sectioned
T39889	65918-65926	UMLS/C1522472	denotes	ections
T39890	66091-66099	UMLS/C1522472	denotes	ections
T39891	66258-66266	UMLS/C1522472	denotes	ctions w
T39892	65942-65945	UMLS/C0000925	denotes	ut
T39893	65548-65558	UMLS/C0521095	denotes	determined
T39894	66009-66013	UMLS/C0023175	denotes	ead
T39895	65722-65726	UMLS/C1511726	denotes	ata
T39896	65930-65936	UMLS/C0007776	denotes	ortex
T39897	66120-66135	UMLS/C0007776	denotes	erebral cortex,
T39898	65732-65741	UMLS/C0017262	denotes	xpressed
T39899	66208-66215	UMLS/C1547288	denotes	lcohol
T39900	65959-65965	UMLS/C1552080	denotes	oated
T39901	65303-65309	UMLS/C0006353	denotes	buffer
T39902	66256-66257	UMLS/C2349943	denotes	s
T39903	66014-66021	UMLS/C0376259	denotes	itrate
T39904	65139-65148	UMLS/C0019638	denotes	Histology
T39905	65942-65945	UMLS/C1306235	denotes	ut
T39906	65432-65441	UMLS/C0700320	denotes	sectioned
T39907	65918-65926	UMLS/C0700320	denotes	ections
T39908	66091-66099	UMLS/C0700320	denotes	ections
T39909	66258-66266	UMLS/C0700320	denotes	ctions w
T39910	66052-66071	UMLS/C0181845	denotes	lectron microscope.
T39911	66152-66162	UMLS/C0007765	denotes	erebellum,
T39912	65526-65532	UMLS/C1705102	denotes	volume
T39913	65750-65756	UMLS/C1705102	denotes	olume
T39914	65930-65936	UMLS/C2700441	denotes	ortex
T39915	66232-66240	UMLS/C0497805	denotes	araffin
T39916	65869-65877	UMLS/C1521827	denotes	repared
T39917	65732-65741	UMLS/C1515670	denotes	xpressed
T39918	65959-65965	UMLS/C1705944	denotes	oated
T39919	65404-65408	UMLS/C0027950	denotes	Poly
T39920	65362-65372	UMLS/C0011175	denotes	dehydrated
T39921	66169-66179	UMLS/C0011175	denotes	ehydrated
T39922	65959-65965	UMLS/C1697272	denotes	oated
T39923	65344-65360	UMLS/C0029385	denotes	osmium tetroxide
T39924	65732-65741	UMLS/C1171362	denotes	xpressed
T39925	65648-65654	UMLS/C1553496	denotes	fields
T39926	65803-65808	UMLS/C1553496	denotes	ield.
T39927	65376-65382	UMLS/C0441800	denotes	graded
T39928	66183-66189	UMLS/C0441800	denotes	raded
T39929	65835-65843	UMLS/C0936012	denotes	nalysis
T39930	66190-66204	UMLS/C0086045	denotes	oncentrations
T39931	65977-65984	UMLS/C0038128	denotes	tained
T39932	66081-66089	UMLS/C0038128	denotes	taining,
T39933	65959-65965	UMLS/C1704806	denotes	oated
T39934	65202-65211	UMLS/C0205239	denotes	dissected
T39935	65745-65749	UMLS/C0876919	denotes	ean
T39936	65315-65322	UMLS/C0040300	denotes	tissues
T39937	65858-65864	UMLS/C0040300	denotes	issue
T39938	66009-66013	UMLS/C1522538	denotes	ead
T39939	65257-65273	UMLS/C0070066	denotes	paraformaldehyde
T39940	65285-65302	UMLS/C0300984	denotes	sodium cacodylate
T39941	66110-66119	UMLS/C2700399	denotes	ncluding
T39942	65139-65148	UMLS/C1608506	denotes	Histology
T39943	65588-65597	UMLS/C1552738	denotes	described
T39944	65892-65901	UMLS/C1552738	denotes	escribed
T39945	65404-65408	UMLS/C0312003	denotes	Poly
T39946	65705-65712	UMLS/C1561606	denotes	linded
T39947	65971-65976	UMLS/C2348395	denotes	rids
T39948	65526-65532	UMLS/C0449468	denotes	volume
T39949	65750-65756	UMLS/C0449468	denotes	olume
T39950	65705-65712	UMLS/C1561605	denotes	linded
T39951	65959-65965	UMLS/C0453946	denotes	oated
T39952	65705-65712	UMLS/C0150108	denotes	linded
T39953	65564-65572	UMLS/C0013850	denotes	electron
T39954	65814-65822	UMLS/C0013850	denotes	lectron
T39955	66110-66119	UMLS/C0332257	denotes	ncluding
T39956	65564-65572	UMLS/C0013852	denotes	electron
T39957	65814-65822	UMLS/C0013852	denotes	lectron
T39958	65409-65412	UMLS/C0004916	denotes	Bed
T39959	65533-65542	UMLS/C0178587	denotes	densities
T39960	65757-65764	UMLS/C0178587	denotes	ensity
T39961	65191-65196	UMLS/C0023884	denotes	liver
T39962	65823-65834	UMLS/C0205288	denotes	icroscopic
T39963	66256-66257	UMLS/C1552156	denotes	s
T39964	66256-66257	UMLS/C0439223	denotes	s
T39965	65409-65412	UMLS/C0004914	denotes	Bed
T39966	65479-65494	UMLS/C1280260	denotes	skeletal muscle
T39967	65191-65196	UMLS/C0023895	denotes	liver
T39968	65139-65148	UMLS/C0344441	denotes	Histology
T39969	65930-65936	UMLS/C0595905	denotes	ortex
T39970	65432-65441	UMLS/C1551341	denotes	sectioned
T39971	65918-65926	UMLS/C1551341	denotes	ections
T39972	66091-66099	UMLS/C1551341	denotes	ections
T39973	66258-66266	UMLS/C1551341	denotes	ctions w
T39974	66009-66013	UMLS/C1704733	denotes	ead
T39975	66152-66162	UMLS/C0320181	denotes	erebellum,
T39976	65745-65749	UMLS/C2348143	denotes	ean
T39977	65479-65494	UMLS/C1546780	denotes	skeletal muscle
T39978	65745-65749	UMLS/C0444504	denotes	ean
T39979	65835-65843	UMLS/C0002778	denotes	nalysis
T39980	65648-65654	UMLS/C0440042	denotes	fields
T39981	65803-65808	UMLS/C0440042	denotes	ield.
T39982	65467-65474	UMLS/C1522601	denotes	Cardiac
T39983	65191-65196	UMLS/C1278929	denotes	liver
T39984	65705-65712	UMLS/C0456909	denotes	linded
T40572	66641-66650	UMLS/C0030011	denotes	n rates w
T40573	66698-66702	UMLS/C0001128	denotes	desc
T40574	66371-66375	UMLS/C0024554	denotes	male
T40575	66775-66786	UMLS/C0035203	denotes	ion studies
T40576	66927-66938	UMLS/C0035203	denotes	on studies
T40577	66812-66816	UMLS/C0205104	denotes	or t
T40578	66306-66313	UMLS/C0947630	denotes	studies
T40579	66577-66584	UMLS/C0947630	denotes	were p
T40580	66787-66794	UMLS/C0947630	denotes	cells
T40581	66939-66946	UMLS/C0947630	denotes	ere per
T40582	66306-66313	UMLS/C0557651	denotes	studies
T40583	66577-66584	UMLS/C0557651	denotes	were p
T40584	66787-66794	UMLS/C0557651	denotes	cells
T40585	66939-66946	UMLS/C0557651	denotes	ere per
T40586	66490-66501	UMLS/C1706386	denotes	ments were
T40587	66295-66305	UMLS/C0227525	denotes	hepatocyte
T40588	66340-66351	UMLS/C0227525	denotes	hepatocytes
T40589	66918-66925	UMLS/C0036189	denotes	Respira
T40590	66546-66552	UMLS/C1139930	denotes	Trigly
T40591	66826-66833	UMLS/C1139930	denotes	and res
T40592	66807-66811	UMLS/C1446863	denotes	n pr
T40593	66969-66977	UMLS/C0150312	denotes	of 5 mM
T40594	67003-67011	UMLS/C0150312	denotes	of 10 μM
T40595	66918-66925	UMLS/C0520481	denotes	Respira
T40596	66775-66786	UMLS/C0282636	denotes	ion studies
T40597	66927-66938	UMLS/C0282636	denotes	on studies
T40598	66546-66552	UMLS/C0407295	denotes	Trigly
T40599	66826-66833	UMLS/C0407295	denotes	and res
T40600	66442-66462	UMLS/C1158366	denotes	acid oxidation and t
T40601	66762-66769	UMLS/C1552853	denotes	For re
T40602	66817-66825	UMLS/C0332152	denotes	plating
T40603	66535-66540	UMLS/C1269647	denotes	re pl
T40604	66796-66801	UMLS/C1269647	denotes	re sp
T40605	66306-66313	UMLS/C1880229	denotes	studies
T40606	66577-66584	UMLS/C1880229	denotes	were p
T40607	66787-66794	UMLS/C1880229	denotes	cells
T40608	66939-66946	UMLS/C1880229	denotes	ere per
T40609	66725-66734	UMLS/C0205170	denotes	d for tot
T40610	66986-66995	UMLS/C0038617	denotes	in the p
T40611	66890-66895	UMLS/C1282910	denotes	ontai
T40612	66762-66769	UMLS/C1550605	denotes	For re
T40613	66754-66761	UMLS/C0033684	denotes	content
T40614	66890-66895	UMLS/C1552828	denotes	ontai
T40615	67032-67049	UMLS/C0231832	denotes	n rates were expr
T40616	66591-66600	UMLS/C1550369	denotes	d as prev
T40617	66952-66961	UMLS/C1550369	denotes	in the p
T40618	67073-67075	UMLS/C0030054	denotes	·
T40619	66535-66540	UMLS/C1704653	denotes	re pl
T40620	66796-66801	UMLS/C1704653	denotes	re sp
T40621	66490-66501	UMLS/C0681814	denotes	ments were
T40622	67055-67064	UMLS/C0017262	denotes	as nmol O
T40623	66281-66288	UMLS/C0439631	denotes	Primary
T40624	66314-66321	UMLS/C0439631	denotes	Primary
T40625	66651-66656	UMLS/C0871208	denotes	re qu
T40626	66872-66878	UMLS/C0006353	denotes	descri
T40627	66322-66330	UMLS/C0430400	denotes	cultures
T40628	66739-66744	UMLS/C0439175	denotes	llula
T40629	66725-66734	UMLS/C0205202	denotes	d for tot
T40630	66306-66313	UMLS/C1705923	denotes	studies
T40631	66577-66584	UMLS/C1705923	denotes	were p
T40632	66787-66794	UMLS/C1705923	denotes	cells
T40633	66939-66946	UMLS/C1705923	denotes	ere per
T40634	66631-66640	UMLS/C0030233	denotes	e oxidati
T40635	66969-66977	UMLS/C0392148	denotes	of 5 mM
T40636	67003-67011	UMLS/C0392148	denotes	of 10 μM
T40637	66762-66769	UMLS/C0456205	denotes	For re
T40638	66591-66600	UMLS/C0884358	denotes	d as prev
T40639	66952-66961	UMLS/C0884358	denotes	in the p
T40640	66357-66365	UMLS/C1521827	denotes	prepared
T40641	66306-66313	UMLS/C2349977	denotes	studies
T40642	66577-66584	UMLS/C2349977	denotes	were p
T40643	66787-66794	UMLS/C2349977	denotes	cells
T40644	66939-66946	UMLS/C2349977	denotes	ere per
T40645	66281-66288	UMLS/C0205225	denotes	Primary
T40646	66314-66321	UMLS/C0205225	denotes	Primary
T40647	67022-67030	UMLS/C0035871	denotes	Respirat
T40648	67055-67064	UMLS/C1515670	denotes	as nmol O
T40649	66546-66552	UMLS/C0005971	denotes	Trigly
T40650	66826-66833	UMLS/C0005971	denotes	and res
T40651	66306-66313	UMLS/C2603343	denotes	studies
T40652	66577-66584	UMLS/C2603343	denotes	were p
T40653	66787-66794	UMLS/C2603343	denotes	cells
T40654	66939-66946	UMLS/C2603343	denotes	ere per
T40655	66322-66330	UMLS/C2242979	denotes	cultures
T40656	66371-66375	UMLS/C1706180	denotes	male
T40657	67055-67064	UMLS/C1171362	denotes	as nmol O
T40658	66467-66489	UMLS/C1157337	denotes	ceride synthesis exper
T40659	66554-66576	UMLS/C1157337	denotes	ride synthesis studies
T40660	66651-66656	UMLS/C1521828	denotes	re qu
T40661	66525-66530	UMLS/C0687676	denotes	e cel
T40662	66986-66995	UMLS/C0220918	denotes	in the p
T40663	66897-66907	UMLS/C1549781	denotes	ng 50 μg/m
T40664	66745-66753	UMLS/C0178539	denotes	protein
T40665	66651-66656	UMLS/C1549480	denotes	re qu
T40666	66897-66907	UMLS/C2700400	denotes	ng 50 μg/m
T40667	66371-66375	UMLS/C0325595	denotes	male
T40668	66426-66435	UMLS/C1552738	denotes	bed [47].
T40669	66615-66624	UMLS/C1552738	denotes	d [47]. P
T40670	66706-66715	UMLS/C1552738	denotes	d [48] an
T40671	66880-66889	UMLS/C1552738	denotes	d above)
T40672	67068-67072	UMLS/C0439191	denotes	min−
T40673	66306-66313	UMLS/C0008976	denotes	studies
T40674	66577-66584	UMLS/C0008976	denotes	were p
T40675	66787-66794	UMLS/C0008976	denotes	cells
T40676	66939-66946	UMLS/C0008976	denotes	ere per
T40677	66306-66313	UMLS/C0008972	denotes	studies
T40678	66577-66584	UMLS/C0008972	denotes	were p
T40679	66787-66794	UMLS/C0008972	denotes	cells
T40680	66939-66946	UMLS/C0008972	denotes	ere per
T40681	66535-66540	UMLS/C0007634	denotes	re pl
T40682	66745-66753	UMLS/C0007634	denotes	protein
T40683	66796-66801	UMLS/C0007634	denotes	re sp
T40684	66322-66330	UMLS/C0010453	denotes	cultures
T40685	66535-66540	UMLS/C1948049	denotes	re pl
T40686	66796-66801	UMLS/C1948049	denotes	re sp
T40687	66371-66375	UMLS/C1706429	denotes	male
T40688	66371-66375	UMLS/C0086582	denotes	male
T40689	66725-66734	UMLS/C2349182	denotes	d for tot
T40690	66775-66786	UMLS/C1160636	denotes	ion studies
T40691	66927-66938	UMLS/C1160636	denotes	on studies
T40692	66371-66375	UMLS/C1706428	denotes	male
T40693	66897-66907	UMLS/C0332256	denotes	ng 50 μg/m
T40694	66739-66744	UMLS/C0439810	denotes	llula
T40695	66525-66530	UMLS/C0231290	denotes	e cel
T40696	66535-66540	UMLS/C1136359	denotes	re pl
T40697	66796-66801	UMLS/C1136359	denotes	re sp
T40698	66322-66330	UMLS/C0220814	denotes	cultures
T42210	67836-67844	UMLS/C0444086	denotes	nded alo
T42211	69364-69373	UMLS/C1521721	denotes	d the pla
T42212	68443-68452	UMLS/C1522729	denotes	cols were
T42213	69961-69965	UMLS/C0687080	denotes	ide
T42214	69503-69512	UMLS/C0701415	denotes	s ledge w
T42215	69641-69650	UMLS/C0701415	denotes	s ledge a
T42216	69822-69827	UMLS/C0039717	denotes	pe (2
T42217	67286-67288	UMLS/C0475210	denotes	cm
T42218	67297-67299	UMLS/C0475210	denotes	m
T42219	67308-67310	UMLS/C0475210	denotes	)
T42220	67675-67677	UMLS/C0475210	denotes	×
T42221	67684-67686	UMLS/C0475210	denotes	en
T42222	67750-67752	UMLS/C0475210	denotes	id
T42223	68271-68273	UMLS/C0475210	denotes	an
T42224	68605-68607	UMLS/C0475210	denotes	ov
T42225	68659-68661	UMLS/C0475210	denotes	ha
T42226	69130-69132	UMLS/C0475210	denotes	t
T42227	69173-69175	UMLS/C0475210	denotes	a
T42228	69190-69192	UMLS/C0475210	denotes	am
T42229	69630-69632	UMLS/C0475210	denotes	he
T42230	69837-69839	UMLS/C0475210	denotes	cm
T42231	69846-69848	UMLS/C0475210	denotes	sm
T42232	68225-68231	UMLS/C1882509	denotes	ed on
T42233	68572-68578	UMLS/C1882509	denotes	d on t
T42234	68714-68720	UMLS/C1882509	denotes	in the
T42235	68926-68932	UMLS/C1882509	denotes	as abo
T42236	69686-69691	UMLS/C1882509	denotes	less
T42237	69771-69777	UMLS/C1882509	denotes	n the
T42238	69946-69951	UMLS/C1882509	denotes	four
T42239	67175-67177	UMLS/C0319022	denotes	To
T42240	67589-67591	UMLS/C0319022	denotes	an
T42241	67660-67662	UMLS/C0319022	denotes	de
T42242	68303-68305	UMLS/C0319022	denotes	80
T42243	68681-68683	UMLS/C0319022	denotes	°
T42244	68851-68853	UMLS/C0319022	denotes	b
T42245	68860-68862	UMLS/C0319022	denotes	to
T42246	68975-68977	UMLS/C0319022	denotes	.
T42247	69925-69927	UMLS/C0319022	denotes	th
T42248	70109-70111	UMLS/C0319022	denotes	lo
T42249	70248-70262	UMLS/C0013781	denotes	imulus and an
T42250	70146-70151	UMLS/C0025611	denotes	modu
T42251	70330-70333	UMLS/C1705195	denotes	wit
T42252	67312-67323	UMLS/C0032604	denotes	lystyrene e
T42253	69235-69243	UMLS/C1516050	denotes	if the
T42254	69576-69584	UMLS/C1516050	denotes	if the
T42255	68378-68383	UMLS/C0039593	denotes	incl
T42256	68519-68529	UMLS/C0039593	denotes	: For the
T42257	69415-69419	UMLS/C0039593	denotes	ch m
T42258	69750-69754	UMLS/C0039593	denotes	ch m
T42259	68763-68771	UMLS/C0424013	denotes	d down a
T42260	67457-67470	UMLS/C0041703	denotes	ited States).
T42261	67767-67772	UMLS/C0441987	denotes	s of
T42262	68378-68383	UMLS/C0013702	denotes	incl
T42263	69415-69419	UMLS/C0013702	denotes	ch m
T42264	69750-69754	UMLS/C0013702	denotes	ch m
T42265	67933-67939	UMLS/C1709287	denotes	er of
T42266	67971-67977	UMLS/C1709287	denotes	er of
T42267	68135-68141	UMLS/C1709287	denotes	er of
T42268	67862-67871	UMLS/C0182215	denotes	meter of
T42269	69828-69832	UMLS/C0343138	denotes	cm
T42270	69981-69985	UMLS/C0343138	denotes	rec
T42271	68175-68183	UMLS/C0557033	denotes	rded. Fo
T42272	69991-69999	UMLS/C0557033	denotes	The max
T42273	68242-68246	UMLS/C0181805	denotes	gri
T42274	68630-68634	UMLS/C0181805	denotes	grid
T42275	68323-68328	UMLS/C1552081	denotes	of 6
T42276	68995-69000	UMLS/C1552081	denotes	60 s
T42277	69217-69222	UMLS/C1552081	denotes	60 s
T42278	69553-69558	UMLS/C1552081	denotes	60 s
T42279	67215-67221	UMLS/C1995013	denotes	muscle
T42280	69396-69403	UMLS/C0085639	denotes	(3) Le
T42281	69527-69534	UMLS/C0085639	denotes	(60 s m
T42282	69718-69725	UMLS/C0085639	denotes	(4) Wa
T42283	68237-68241	UMLS/C1705105	denotes	mes
T42284	68625-68629	UMLS/C1705105	denotes	mesh
T42285	67406-67411	UMLS/C1513492	denotes	tor M
T42286	69816-69821	UMLS/C0043157	denotes	oth t
T42287	67412-67419	UMLS/C0728873	denotes	nitor,
T42288	67624-67632	UMLS/C0037585	denotes	tware (H
T42289	67258-67264	UMLS/C1561960	denotes	period
T42290	67885-67894	UMLS/C1705098	denotes	ables tha
T42291	67862-67871	UMLS/C1295726	denotes	meter of
T42292	69354-69358	UMLS/C0935623	denotes	t su
T42293	67565-67571	UMLS/C1709366	denotes	put of
T42294	67595-67602	UMLS/C1546701	denotes	line co
T42295	68283-68289	UMLS/C1705053	denotes	en was
T42296	68492-68498	UMLS/C1705053	denotes	n and
T42297	68742-68748	UMLS/C1705053	denotes	with i
T42298	68823-68829	UMLS/C1705053	denotes	and ho
T42299	68878-68884	UMLS/C1705053	denotes	For t
T42300	68955-68961	UMLS/C1705053	denotes	was in
T42301	67258-67264	UMLS/C2347804	denotes	period
T42302	69159-69167	UMLS/C1710360	denotes	(1.0 cm
T42303	69273-69281	UMLS/C1710360	denotes	for the
T42304	69378-69386	UMLS/C1710360	denotes	, withou
T42305	70105-70108	UMLS/C0035953	denotes	em
T42306	70309-70316	UMLS/C0035953	denotes	was set
T42307	67412-67419	UMLS/C0181904	denotes	nitor,
T42308	69739-69749	UMLS/C1158830	denotes	on test: E
T42309	67258-67264	UMLS/C0439531	denotes	period
T42310	68242-68246	UMLS/C1552983	denotes	gri
T42311	68630-68634	UMLS/C1552983	denotes	grid
T42312	69731-69738	UMLS/C1551030	denotes	initiat
T42313	68618-68623	UMLS/C1547707	denotes	) wir
T42314	69143-69148	UMLS/C1547707	denotes	ircul
T42315	69862-69867	UMLS/C0439541	denotes	face
T42316	69731-69738	UMLS/C0600108	denotes	initiat
T42317	67412-67419	UMLS/C0596972	denotes	nitor,
T42318	67999-68004	UMLS/C0680968	denotes	t, an
T42319	69862-69867	UMLS/C0085756	denotes	face
T42320	67595-67602	UMLS/C1556143	denotes	line co
T42321	69396-69403	UMLS/C0231174	denotes	(3) Le
T42322	69527-69534	UMLS/C0231174	denotes	(60 s m
T42323	69718-69725	UMLS/C0231174	denotes	(4) Wa
T42324	70105-70108	UMLS/C0600140	denotes	em
T42325	70309-70316	UMLS/C0600140	denotes	was set
T42326	70342-70345	UMLS/C1552937	denotes	in
T42327	68283-68289	UMLS/C0199230	denotes	en was
T42328	68492-68498	UMLS/C0199230	denotes	n and
T42329	68742-68748	UMLS/C0199230	denotes	with i
T42330	68823-68829	UMLS/C0199230	denotes	and ho
T42331	68878-68884	UMLS/C0199230	denotes	For t
T42332	68955-68961	UMLS/C0199230	denotes	was in
T42333	70354-70359	UMLS/C0441889	denotes	angl
T42334	69677-69685	UMLS/C0452588	denotes	place i
T42335	67831-67835	UMLS/C0017446	denotes	ext
T42336	68046-68050	UMLS/C0017446	denotes	as
T42337	67595-67602	UMLS/C1552960	denotes	line co
T42338	69855-69861	UMLS/C0205357	denotes	ack su
T42339	68799-68803	UMLS/C1522425	denotes	rem
T42340	68838-68842	UMLS/C1522425	denotes	too
T42341	69094-69098	UMLS/C1522425	denotes	rema
T42342	69450-69454	UMLS/C1522425	denotes	coul
T42343	69349-69353	UMLS/C0332528	denotes	e th
T42344	67994-67998	UMLS/C0040223	denotes	spe
T42345	68785-68790	UMLS/C0040223	denotes	or ho
T42346	69080-69085	UMLS/C0040223	denotes	r how
T42347	69308-69312	UMLS/C0040223	denotes	if i
T42348	69436-69441	UMLS/C0040223	denotes	r how
T42349	69901-69905	UMLS/C0040223	denotes	ook
T42350	70013-70017	UMLS/C0040223	denotes	wed
T42351	70354-70359	UMLS/C0456079	denotes	angl
T42352	69364-69373	UMLS/C0183683	denotes	d the pla
T42353	68846-68850	UMLS/C1883727	denotes	cli
T42354	69909-69913	UMLS/C1883727	denotes	mou
T42355	70105-70108	UMLS/C0011991	denotes	em
T42356	70309-70316	UMLS/C0011991	denotes	was set
T42357	67994-67998	UMLS/C0449243	denotes	spe
T42358	68785-68790	UMLS/C0449243	denotes	or ho
T42359	69080-69085	UMLS/C0449243	denotes	r how
T42360	69308-69312	UMLS/C0449243	denotes	if i
T42361	69436-69441	UMLS/C0449243	denotes	r how
T42362	69901-69905	UMLS/C0449243	denotes	ook
T42363	70013-70017	UMLS/C0449243	denotes	wed
T42364	68341-68346	UMLS/C1550718	denotes	if a
T42365	69013-69018	UMLS/C1550718	denotes	an a
T42366	67187-67194	UMLS/C1553889	denotes	general
T42367	67836-67844	UMLS/C0205391	denotes	nded alo
T42368	68378-68383	UMLS/C0183885	denotes	incl
T42369	69415-69419	UMLS/C0183885	denotes	ch m
T42370	69750-69754	UMLS/C0183885	denotes	ch m
T42371	69828-69832	UMLS/C0183828	denotes	cm
T42372	69981-69985	UMLS/C0183828	denotes	rec
T42373	69828-69832	UMLS/C1704921	denotes	cm
T42374	69981-69985	UMLS/C1704921	denotes	rec
T42375	68854-68859	UMLS/C0561942	denotes	o the
T42376	69328-69333	UMLS/C0561942	denotes	wn on
T42377	68237-68241	UMLS/C0441650	denotes	mes
T42378	68625-68629	UMLS/C0441650	denotes	mesh
T42379	68353-68359	UMLS/C0003062	denotes	l did
T42380	68703-68709	UMLS/C0003062	denotes	was pl
T42381	69025-69031	UMLS/C0003062	denotes	id not
T42382	67508-67513	UMLS/C1705858	denotes	ame c
T42383	68846-68850	UMLS/C1515187	denotes	cli
T42384	69909-69913	UMLS/C1515187	denotes	mou
T42385	69477-69484	UMLS/C0205415	denotes	on a 0.
T42386	67445-67455	UMLS/C0006754	denotes	lifornia,
T42387	67933-67939	UMLS/C1554106	denotes	er of
T42388	67971-67977	UMLS/C1554106	denotes	er of
T42389	68135-68141	UMLS/C1554106	denotes	er of
T42390	67914-67922	UMLS/C1552866	denotes	uded the
T42391	68384-68392	UMLS/C1552866	denotes	ded in t
T42392	68470-68477	UMLS/C1719822	denotes	ws. (1)
T42393	67492-67502	UMLS/C1282914	denotes	rrounded b
T42394	67720-67731	UMLS/C1282914	denotes	ounding zon
T42395	68101-68112	UMLS/C1282914	denotes	ounding the
T42396	68360-68372	UMLS/C0575123	denotes	ot fall. The
T42397	69032-69044	UMLS/C0575123	denotes	fall; (2) Pl
T42398	69677-69685	UMLS/C1552850	denotes	place i
T42399	69150-69158	UMLS/C1282913	denotes	platfor
T42400	68608-68613	UMLS/C1282910	denotes	the
T42401	68936-68941	UMLS/C1282910	denotes	nd th
T42402	69133-69138	UMLS/C1282910	denotes	e flo
T42403	67595-67602	UMLS/C1550648	denotes	line co
T42404	69322-69327	UMLS/C0006823	denotes	imb d
T42405	69458-69463	UMLS/C0006823	denotes	intai
T42406	69677-69685	UMLS/C0439659	denotes	place i
T42407	68582-68585	UMLS/C1552827	denotes	f a
T42408	68867-68870	UMLS/C1552827	denotes	the
T42409	68608-68613	UMLS/C1552828	denotes	the
T42410	68936-68941	UMLS/C1552828	denotes	nd th
T42411	69133-69138	UMLS/C1552828	denotes	e flo
T42412	68728-68734	UMLS/C1552826	denotes	of the
T42413	69785-69791	UMLS/C1552826	denotes	f a sq
T42414	69956-69960	UMLS/C0205450	denotes	out
T42415	70146-70151	UMLS/C0678536	denotes	modu
T42416	68175-68183	UMLS/C2355580	denotes	rded. Fo
T42417	69991-69999	UMLS/C2355580	denotes	The max
T42418	67412-67419	UMLS/C0150369	denotes	nitor,
T42419	68039-68045	UMLS/C1552820	denotes	er are
T42420	68117-68123	UMLS/C1552820	denotes	er. Th
T42421	67855-67861	UMLS/C0439751	denotes	re per
T42422	69612-69618	UMLS/C0439751	denotes	ength
T42423	67831-67835	UMLS/C1504310	denotes	ext
T42424	68046-68050	UMLS/C1504310	denotes	as
T42425	68807-68815	UMLS/C1527428	denotes	d on the
T42426	69102-69110	UMLS/C1527428	denotes	on an e
T42427	69257-69265	UMLS/C1527428	denotes	on the
T42428	70123-70132	UMLS/C1274022	denotes	ized, spe
T42429	67905-67913	UMLS/C0936012	denotes	yzed inc
T42430	69961-69965	UMLS/C0232013	denotes	ide
T42431	67258-67264	UMLS/C0025344	denotes	period
T42432	67695-67699	UMLS/C0680812	denotes	and
T42433	67732-67736	UMLS/C0680812	denotes	tha
T42434	67514-67524	UMLS/C1549781	denotes	ntaining a
T42435	68592-68600	UMLS/C0205250	denotes	ted (47
T42436	69117-69125	UMLS/C0205250	denotes	(47 cm
T42437	67187-67194	UMLS/C0205246	denotes	general
T42438	67914-67922	UMLS/C2700399	denotes	uded the
T42439	68384-68392	UMLS/C2700399	denotes	ded in t
T42440	67445-67455	UMLS/C0324542	denotes	lifornia,
T42441	67933-67939	UMLS/C0237753	denotes	er of
T42442	67971-67977	UMLS/C0237753	denotes	er of
T42443	68135-68141	UMLS/C0237753	denotes	er of
T42444	67514-67524	UMLS/C2700400	denotes	ntaining a
T42445	68799-68803	UMLS/C0870371	denotes	rem
T42446	68838-68842	UMLS/C0870371	denotes	too
T42447	69094-69098	UMLS/C0870371	denotes	rema
T42448	69450-69454	UMLS/C0870371	denotes	coul
T42449	68443-68452	UMLS/C0442711	denotes	cols were
T42450	70152-70162	UMLS/C0332298	denotes	ar treadmi
T42451	70172-70181	UMLS/C2712999	denotes	(Columbus
T42452	70217-70226	UMLS/C2712999	denotes	ipped wit
T42453	67349-67358	UMLS/C1552738	denotes	scribed [
T42454	67406-67411	UMLS/C1705994	denotes	tor M
T42455	67663-67669	UMLS/C1704788	denotes	ine a
T42456	68470-68477	UMLS/C0332282	denotes	ws. (1)
T42457	68413-68420	UMLS/C1704779	denotes	ry [50]
T42458	68470-68477	UMLS/C0332283	denotes	ws. (1)
T42459	68225-68231	UMLS/C1704765	denotes	ed on
T42460	68572-68578	UMLS/C1704765	denotes	d on t
T42461	68714-68720	UMLS/C1704765	denotes	in the
T42462	68926-68932	UMLS/C1704765	denotes	as abo
T42463	69686-69691	UMLS/C1704765	denotes	less
T42464	69771-69777	UMLS/C1704765	denotes	n the
T42465	69946-69951	UMLS/C1704765	denotes	four
T42466	67914-67922	UMLS/C0332257	denotes	uded the
T42467	68384-68392	UMLS/C0332257	denotes	ded in t
T42468	67514-67524	UMLS/C0332256	denotes	ntaining a
T42469	67927-67932	UMLS/C0439810	denotes	l num
T42470	68129-68134	UMLS/C0439810	denotes	l num
T42471	67195-67210	UMLS/C0683317	denotes	activity levels
T42472	69797-69812	UMLS/C1854419	denotes	utlined by whit
T42473	68283-68289	UMLS/C1710031	denotes	en was
T42474	68492-68498	UMLS/C1710031	denotes	n and
T42475	68742-68748	UMLS/C1710031	denotes	with i
T42476	68823-68829	UMLS/C1710031	denotes	and ho
T42477	68878-68884	UMLS/C1710031	denotes	For t
T42478	68955-68961	UMLS/C1710031	denotes	was in
T42479	69354-69358	UMLS/C0337815	denotes	t su
T42480	69739-69749	UMLS/C0589507	denotes	on test: E
T42481	67836-67844	UMLS/C0439792	denotes	nded alo
T42482	69828-69832	UMLS/C1704747	denotes	cm
T42483	69981-69985	UMLS/C1704747	denotes	rec
T42484	68283-68289	UMLS/C0430054	denotes	en was
T42485	68492-68498	UMLS/C0430054	denotes	n and
T42486	68742-68748	UMLS/C0430054	denotes	with i
T42487	68823-68829	UMLS/C0430054	denotes	and ho
T42488	68878-68884	UMLS/C0430054	denotes	For t
T42489	68955-68961	UMLS/C0430054	denotes	was in
T42490	69464-69472	UMLS/C1314677	denotes	its bal
T42491	69862-69867	UMLS/C1704739	denotes	face
T42492	69828-69832	UMLS/C1018721	denotes	cm
T42493	69981-69985	UMLS/C1018721	denotes	rec
T42494	70330-70333	UMLS/C1552685	denotes	wit
T42495	68315-68322	UMLS/C0806909	denotes	um scor
T42496	68987-68994	UMLS/C0806909	denotes	score o
T42497	69209-69216	UMLS/C0806909	denotes	score o
T42498	69290-69297	UMLS/C0806909	denotes	amount
T42499	69541-69548	UMLS/C0806909	denotes	. A sco
T42500	70005-70012	UMLS/C0806909	denotes	ime all
T42501	69150-69158	UMLS/C0205113	denotes	platfor
T42502	69619-69625	UMLS/C1444754	denotes	51 cm)
T42503	68618-68623	UMLS/C0016249	denotes	) wir
T42504	69143-69148	UMLS/C0016249	denotes	ircul
T42505	69881-69886	UMLS/C0549177	denotes	letop
T42506	70152-70162	UMLS/C1882979	denotes	ar treadmi
T42507	69477-69484	UMLS/C0560184	denotes	on a 0.
T42508	68202-68213	UMLS/C0871311	denotes	en test, mi
T42509	68512-68524	UMLS/C0871311	denotes	n tests: For
T42510	68543-68555	UMLS/C0871311	denotes	n tests, eac
T42511	68903-68914	UMLS/C0871311	denotes	test, mice
T42512	68256-68263	UMLS/C0205120	denotes	res per
T42513	68644-68651	UMLS/C0205120	denotes	es per
T42514	69938-69944	UMLS/C0205120	denotes	lace a
T42515	68772-68776	UMLS/C0205104	denotes	d wa
T42516	69334-69338	UMLS/C0205104	denotes	a ve
T42517	68315-68322	UMLS/C1552615	denotes	um scor
T42518	68987-68994	UMLS/C1552615	denotes	score o
T42519	69209-69216	UMLS/C1552615	denotes	score o
T42520	69290-69297	UMLS/C1552615	denotes	amount
T42521	69541-69548	UMLS/C1552615	denotes	. A sco
T42522	70005-70012	UMLS/C1552615	denotes	ime all
T42523	69677-69685	UMLS/C1272689	denotes	place i
T42524	69477-69484	UMLS/C0560187	denotes	on a 0.
T42525	67268-67279	UMLS/C0522503	denotes	transparent
T42526	67687-67694	UMLS/C0205099	denotes	ral zon
T42527	68039-68045	UMLS/C0205099	denotes	er are
T42528	68117-68123	UMLS/C0205099	denotes	er. Th
T42529	69966-69973	UMLS/C0205101	denotes	f the t
T42530	67706-67716	UMLS/C0205100	denotes	pheral or
T42531	67820-67830	UMLS/C0205100	denotes	pheral are
T42532	69396-69403	UMLS/C1272705	denotes	(3) Le
T42533	69527-69534	UMLS/C1272705	denotes	(60 s m
T42534	69718-69725	UMLS/C1272705	denotes	(4) Wa
T42535	70112-70122	UMLS/C0392674	denotes	ing a moto
T42536	69739-69749	UMLS/C1704686	denotes	on test: E
T42537	67603-67611	UMLS/C0009622	denotes	puter. T
T42538	70231-70239	UMLS/C0014672	denotes	electric
T42539	67994-67998	UMLS/C0392761	denotes	spe
T42540	68785-68790	UMLS/C0392761	denotes	or ho
T42541	69080-69085	UMLS/C0392761	denotes	r how
T42542	69308-69312	UMLS/C0392761	denotes	if i
T42543	69436-69441	UMLS/C0392761	denotes	r how
T42544	69901-69905	UMLS/C0392761	denotes	ook
T42545	70013-70017	UMLS/C0392761	denotes	wed
T42546	70330-70333	UMLS/C1552652	denotes	wit
T42547	67994-67998	UMLS/C1632851	denotes	spe
T42548	68785-68790	UMLS/C1632851	denotes	or ho
T42549	69080-69085	UMLS/C1632851	denotes	r how
T42550	69308-69312	UMLS/C1632851	denotes	if i
T42551	69436-69441	UMLS/C1632851	denotes	r how
T42552	69901-69905	UMLS/C1632851	denotes	ook
T42553	70013-70017	UMLS/C1632851	denotes	wed
T42554	69477-69484	UMLS/C0014653	denotes	on a 0.
T42555	69739-69749	UMLS/C0678321	denotes	on test: E
T42556	69349-69353	UMLS/C0392758	denotes	e th
T42557	70018-70025	UMLS/C0683607	denotes	as 60 s
T42558	70263-70271	UMLS/C0234402	denotes	djustabl
T42559	67994-67998	UMLS/C1547403	denotes	spe
T42560	68785-68790	UMLS/C1547403	denotes	or ho
T42561	69080-69085	UMLS/C1547403	denotes	r how
T42562	69308-69312	UMLS/C1547403	denotes	if i
T42563	69436-69441	UMLS/C1547403	denotes	r how
T42564	69901-69905	UMLS/C1547403	denotes	ook
T42565	70013-70017	UMLS/C1547403	denotes	wed
T42566	67258-67264	UMLS/C0221193	denotes	period
T42567	68799-68803	UMLS/C0392744	denotes	rem
T42568	68838-68842	UMLS/C0392744	denotes	too
T42569	69094-69098	UMLS/C0392744	denotes	rema
T42570	69450-69454	UMLS/C0392744	denotes	coul
T42571	69731-69738	UMLS/C0080331	denotes	initiat
T42572	67855-67861	UMLS/C0444667	denotes	re per
T42573	69612-69618	UMLS/C0444667	denotes	ength
T42574	67885-67894	UMLS/C0439828	denotes	ables tha
T42575	70317-70325	UMLS/C0439830	denotes	at 35 m/
T42576	69661-69672	UMLS/C0332156	denotes	to the sta
T42577	70330-70333	UMLS/C1318139	denotes	wit
T42578	68175-68183	UMLS/C1548330	denotes	rded. Fo
T42579	69991-69999	UMLS/C1548330	denotes	The max
T42580	67959-67963	UMLS/C0205170	denotes	as
T42581	68054-68058	UMLS/C0205170	denotes	as
T42582	70105-70108	UMLS/C1947934	denotes	em
T42583	70309-70316	UMLS/C1947934	denotes	was set
T42584	68014-68022	UMLS/C0012751	denotes	ance tra
T42585	68066-68074	UMLS/C0012751	denotes	ance tra
T42586	67595-67602	UMLS/C1548328	denotes	line co
T42587	69349-69353	UMLS/C0205168	denotes	e th
T42588	68799-68803	UMLS/C0205166	denotes	rem
T42589	68838-68842	UMLS/C0205166	denotes	too
T42590	69094-69098	UMLS/C0205166	denotes	rema
T42591	69450-69454	UMLS/C0205166	denotes	coul
T42592	67094-67104	UMLS/C1261322	denotes	Evaluation
T42593	69298-69304	UMLS/C1561574	denotes	f time
T42594	67258-67264	UMLS/C0332182	denotes	period
T42595	69868-69875	UMLS/C0205148	denotes	f a lar
T42596	67534-67540	UMLS/C1704640	denotes	rix of
T42597	68413-68420	UMLS/C0337088	denotes	ry [50]
T42598	67534-67540	UMLS/C1704639	denotes	rix of
T42599	67831-67835	UMLS/C0205146	denotes	ext
T42600	68046-68050	UMLS/C0205146	denotes	as
T42601	70302-70307	UMLS/C0205143	denotes	locit
T42602	69176-69181	UMLS/C1280412	denotes	d 3.0
T42603	67994-67998	UMLS/C1548318	denotes	spe
T42604	68785-68790	UMLS/C1548318	denotes	or ho
T42605	69080-69085	UMLS/C1548318	denotes	r how
T42606	69308-69312	UMLS/C1548318	denotes	if i
T42607	69436-69441	UMLS/C1548318	denotes	r how
T42608	69901-69905	UMLS/C1548318	denotes	ook
T42609	70013-70017	UMLS/C1548318	denotes	wed
T42610	67247-67251	UMLS/C0205136	denotes	over
T42611	69862-69867	UMLS/C0740259	denotes	face
T42612	68256-68263	UMLS/C1552595	denotes	res per
T42613	68644-68651	UMLS/C1552595	denotes	es per
T42614	69938-69944	UMLS/C1552595	denotes	lace a
T42615	67412-67419	UMLS/C1704646	denotes	nitor,
T42616	68378-68383	UMLS/C0022885	denotes	incl
T42617	69415-69419	UMLS/C0022885	denotes	ch m
T42618	69750-69754	UMLS/C0022885	denotes	ch m
T42619	67595-67602	UMLS/C0205132	denotes	line co
T42620	68341-68346	UMLS/C1947971	denotes	if a
T42621	69013-69018	UMLS/C1947971	denotes	an a
T42622	67108-67126	UMLS/C0026606	denotes	locomotor activity
T42623	68582-68585	UMLS/C0324740	denotes	f a
T42624	68867-68870	UMLS/C0324740	denotes	the
T42625	69235-69243	UMLS/C1552601	denotes	if the
T42626	69576-69584	UMLS/C1552601	denotes	if the
T42627	67324-67334	UMLS/C1705653	denotes	closures a
T42628	67478-67487	UMLS/C1705653	denotes	closure w
T42629	67981-67988	UMLS/C1705654	denotes	ies, th
T42630	67981-67988	UMLS/C1550548	denotes	ies, th
T42631	68854-68859	UMLS/C2584300	denotes	o the
T42632	69328-69333	UMLS/C2584300	denotes	wn on
T42633	70340-70341	UMLS/C2349943	denotes	e
T42634	67780-67784	UMLS/C0441239	denotes	bei
T42635	67879-67883	UMLS/C0441239	denotes	. Va
T42636	68758-68762	UMLS/C0018670	denotes	ient
T42637	68443-68452	UMLS/C2349977	denotes	cols were
T42638	70152-70162	UMLS/C0009932	denotes	ar treadmi
T42639	68758-68762	UMLS/C1281590	denotes	ient
T42640	67412-67419	UMLS/C1516647	denotes	nitor,
T42641	68283-68289	UMLS/C0220909	denotes	en was
T42642	68492-68498	UMLS/C0220909	denotes	n and
T42643	68742-68748	UMLS/C0220909	denotes	with i
T42644	68823-68829	UMLS/C0220909	denotes	and ho
T42645	68878-68884	UMLS/C0220909	denotes	For t
T42646	68955-68961	UMLS/C0220909	denotes	was in
T42647	68283-68289	UMLS/C0220908	denotes	en was
T42648	68492-68498	UMLS/C0220908	denotes	n and
T42649	68742-68748	UMLS/C0220908	denotes	with i
T42650	68823-68829	UMLS/C0220908	denotes	and ho
T42651	68878-68884	UMLS/C0220908	denotes	For t
T42652	68955-68961	UMLS/C0220908	denotes	was in
T42653	70199-70210	UMLS/C0348000	denotes	treadmill
T42654	67141-67153	UMLS/C2698977	denotes	capabilities
T42655	68283-68289	UMLS/C1305399	denotes	en was
T42656	68492-68498	UMLS/C1305399	denotes	n and
T42657	68742-68748	UMLS/C1305399	denotes	with i
T42658	68823-68829	UMLS/C1305399	denotes	and ho
T42659	68878-68884	UMLS/C1305399	denotes	For t
T42660	68955-68961	UMLS/C1305399	denotes	was in
T42661	69816-69821	UMLS/C0220938	denotes	oth t
T42662	70342-70345	UMLS/C0702093	denotes	in
T42663	67258-67264	UMLS/C1948053	denotes	period
T42664	70330-70333	UMLS/C1442518	denotes	wit
T42665	69855-69861	UMLS/C1948044	denotes	ack su
T42666	68247-68251	UMLS/C2348395	denotes	(16
T42667	68635-68639	UMLS/C2348395	denotes	(16
T42668	68264-68267	UMLS/C0330664	denotes	10
T42669	68652-68655	UMLS/C0330664	denotes	0 c
T42670	70330-70333	UMLS/C0001774	denotes	wit
T42671	68283-68289	UMLS/C1698960	denotes	en was
T42672	68492-68498	UMLS/C1698960	denotes	n and
T42673	68742-68748	UMLS/C1698960	denotes	with i
T42674	68823-68829	UMLS/C1698960	denotes	and ho
T42675	68878-68884	UMLS/C1698960	denotes	For t
T42676	68955-68961	UMLS/C1698960	denotes	was in
T42677	69364-69373	UMLS/C1317973	denotes	d the pla
T42678	68175-68183	UMLS/C0034869	denotes	rded. Fo
T42679	69991-69999	UMLS/C0034869	denotes	The max
T42680	70330-70333	UMLS/C0036849	denotes	wit
T42681	70172-70181	UMLS/C0184069	denotes	(Columbus
T42682	70217-70226	UMLS/C0184069	denotes	ipped wit
T42683	67094-67104	UMLS/C0220825	denotes	Evaluation
T42684	67178-67186	UMLS/C0220825	denotes	evaluate
T42685	67237-67246	UMLS/C0220825	denotes	evaluated
T42686	68237-68241	UMLS/C0005978	denotes	mes
T42687	68625-68629	UMLS/C0005978	denotes	mesh
T42688	69196-69204	UMLS/C1301886	denotes	). A max
T42689	70330-70333	UMLS/C0542559	denotes	wit
T42690	67215-67221	UMLS/C0026845	denotes	muscle
T42691	68413-68420	UMLS/C1555716	denotes	ry [50]
T42692	67981-67988	UMLS/C1555714	denotes	ies, th
T42693	70152-70162	UMLS/C1550141	denotes	ar treadmi
T42694	69855-69861	UP/P91682	denotes	ack su
T42695	68323-68328	UMLS/C0449820	denotes	of 6
T42696	68995-69000	UMLS/C0449820	denotes	60 s
T42697	69217-69222	UMLS/C0449820	denotes	60 s
T42698	69553-69558	UMLS/C0449820	denotes	60 s
T42699	67094-67104	UMLS/C1550157	denotes	Evaluation
T42700	68443-68452	UMLS/C1507394	denotes	cols were
T42701	68582-68585	UMLS/C1704458	denotes	f a
T42702	68867-68870	UMLS/C1704458	denotes	the
T42703	68341-68346	UMLS/C1442162	denotes	if a
T42704	69013-69018	UMLS/C1442162	denotes	an a
T42705	67398-67404	UMLS/C1704459	denotes	stem (
T42706	67617-67623	UMLS/C1704459	denotes	tem so
T42707	70182-70188	UMLS/C1704459	denotes	Instru
T42708	69862-69867	UMLS/C0005680	denotes	face
T42709	70123-70132	UMLS/C0557351	denotes	ized, spe
T42710	68023-68031	UMLS/C1555670	denotes	eled in
T42711	68075-68083	UMLS/C1555670	denotes	eled in
T42712	67933-67939	UMLS/C0449788	denotes	er of
T42713	67971-67977	UMLS/C0449788	denotes	er of
T42714	68135-68141	UMLS/C0449788	denotes	er of
T42715	69816-69821	UMLS/C0007457	denotes	oth t
T42716	68763-68771	UMLS/C1704322	denotes	d down a
T42717	68378-68383	UMLS/C0392366	denotes	incl
T42718	69415-69419	UMLS/C0392366	denotes	ch m
T42719	69750-69754	UMLS/C0392366	denotes	ch m
T42720	70152-70162	UMLS/C1547100	denotes	ar treadmi
T42721	68175-68183	UMLS/C1553414	denotes	rded. Fo
T42722	69991-69999	UMLS/C1553414	denotes	The max
T42723	68763-68771	UMLS/C0029266	denotes	d down a
T42724	67398-67404	UMLS/C0449913	denotes	stem (
T42725	67617-67623	UMLS/C0449913	denotes	tem so
T42726	70182-70188	UMLS/C0449913	denotes	Instru
T42727	67836-67844	UMLS/C0231449	denotes	nded alo
T42728	67595-67602	UMLS/C1553412	denotes	line co
T42729	67836-67844	UMLS/C0231448	denotes	nded alo
T42730	68758-68762	UMLS/C1706305	denotes	ient
T42731	67324-67334	UMLS/C0683898	denotes	closures a
T42732	67478-67487	UMLS/C0683898	denotes	closure w
T42733	67159-67174	UMLS/C0231484	denotes	muscle function
T42734	67398-67404	UMLS/C1553451	denotes	stem (
T42735	67617-67623	UMLS/C1553451	denotes	tem so
T42736	70182-70188	UMLS/C1553451	denotes	Instru
T42737	70231-70239	UMLS/C1690540	denotes	electric
T42738	68799-68803	UMLS/C1706317	denotes	rem
T42739	68838-68842	UMLS/C1706317	denotes	too
T42740	69094-69098	UMLS/C1706317	denotes	rema
T42741	69450-69454	UMLS/C1706317	denotes	coul
T42742	68413-68420	UMLS/C0542351	denotes	ry [50]
T42743	68193-68201	UMLS/C0443241	denotes	rted scr
T42744	68294-68302	UMLS/C0443241	denotes	rted to
T42745	68503-68511	UMLS/C0443241	denotes	ted scre
T42746	68894-68902	UMLS/C0443241	denotes	d screen
T42747	68966-68974	UMLS/C0443241	denotes	d to 180
T42748	67695-67699	UMLS/C1710706	denotes	and
T42749	67732-67736	UMLS/C1710706	denotes	tha
T42750	70317-70325	UMLS/C1547053	denotes	at 35 m/
T42751	69322-69327	UMLS/C0344312	denotes	imb d
T42752	69458-69463	UMLS/C0344312	denotes	intai
T42753	69881-69886	UMLS/C0443228	denotes	letop
T42754	70152-70162	UMLS/C0243148	denotes	ar treadmi
T42755	67508-67513	UMLS/C0180979	denotes	ame c
T42756	68728-68734	UMLS/C0444598	denotes	of the
T42757	69785-69791	UMLS/C0444598	denotes	f a sq
T42758	68582-68585	UMLS/C0453888	denotes	f a
T42759	68867-68870	UMLS/C0453888	denotes	the
T42760	67994-67998	UMLS/C1704250	denotes	spe
T42761	68785-68790	UMLS/C1704250	denotes	or ho
T42762	69080-69085	UMLS/C1704250	denotes	r how
T42763	69308-69312	UMLS/C1704250	denotes	if i
T42764	69436-69441	UMLS/C1704250	denotes	r how
T42765	69901-69905	UMLS/C1704250	denotes	ook
T42766	70013-70017	UMLS/C1704250	denotes	wed
T42767	67927-67932	UMLS/C0439175	denotes	l num
T42768	68129-68134	UMLS/C0439175	denotes	l num
T42769	69881-69886	UMLS/C1704243	denotes	letop
T42770	69050-69063	UMLS/C0430678	denotes	test: Each m
T42771	67534-67540	UMLS/C1706515	denotes	rix of
T42772	69862-69867	UMLS/C0027567	denotes	face
T42773	67508-67513	UMLS/C0080089	denotes	ame c
T42774	67258-67264	UMLS/C0031084	denotes	period
T42775	68443-68452	UMLS/C2348563	denotes	cols were
T42776	69503-69512	UMLS/C0600424	denotes	s ledge w
T42777	69641-69650	UMLS/C0600424	denotes	s ledge a
T42778	70342-70345	UMLS/C0439232	denotes	in
T42779	69364-69373	UMLS/C0344211	denotes	d the pla
T42780	67412-67419	UMLS/C1521743	denotes	nitor,
T42781	67780-67784	UMLS/C0337189	denotes	bei
T42782	67879-67883	UMLS/C0337189	denotes	. Va
T42783	70340-70341	UMLS/C1552156	denotes	e
T42784	70340-70341	UMLS/C0439223	denotes	e
T42785	69298-69304	UMLS/C1265611	denotes	f time
T42786	70152-70162	UMLS/C2587213	denotes	ar treadmi
T42787	67943-67954	UMLS/C0945826	denotes	lations, as
T42788	68145-68156	UMLS/C0945826	denotes	lations and
T42789	67554-67559	UMLS/C1709450	denotes	rs, t
T42790	69464-69472	UMLS/C0024501	denotes	its bal
T42791	67815-67819	UMLS/C0323983	denotes	per
T43884	70923-70929	UMLS/C0015264	denotes	ort wa
T43885	71045-71051	UMLS/C0015264	denotes	ort. V
T43886	70905-70913	UMLS/C0549178	denotes	tinue. M
T43887	70370-70377	UMLS/C0947630	denotes	studies
T43888	70670-70672	UMLS/C0319022	denotes	a
T43889	70690-70692	UMLS/C0319022	denotes	e
T43890	70729-70731	UMLS/C0319022	denotes	r
T43891	70902-70904	UMLS/C0319022	denotes	co
T43892	71033-71035	UMLS/C0319022	denotes	ma
T43893	70760-70765	UMLS/C0025611	denotes	ed of
T43894	70829-70834	UMLS/C0025611	denotes	ed wa
T43895	70673-70678	UMLS/C0683607	denotes	low t
T43896	71064-71074	UMLS/C0444686	denotes	culated us
T43897	70370-70377	UMLS/C1880229	denotes	studies
T43898	71141-71152	UMLS/C0009830	denotes	sumption re
T43899	71094-71100	UMLS/C1704610	denotes	ues ov
T43900	70638-70647	UMLS/C1524026	denotes	metabolic
T43901	70420-70427	UMLS/C1947934	denotes	running
T43902	70732-70735	UMLS/C1947934	denotes	n u
T43903	70546-70556	UMLS/C1709305	denotes	took place
T43904	70457-70461	UMLS/C0806140	denotes	flow
T43905	71101-71105	UMLS/C0205136	denotes	r 1
T43906	70389-70399	UMLS/C0521095	denotes	determined
T43907	70934-70944	UMLS/C0521095	denotes	ermined wh
T43908	70986-70998	UMLS/C0445194	denotes	er output an
T43909	70583-70590	UMLS/C1879688	denotes	ambient
T43910	70895-70901	UMLS/C1299582	denotes	ble to
T43911	70580-70581	UMLS/C2349943	denotes	m
T43912	70772-70773	UMLS/C2349943	denotes	i
T43913	70854-70855	UMLS/C2349943	denotes	i
T43914	70602-70606	UMLS/C0439475	denotes	torr
T43915	70736-70738	UMLS/C0547043	denotes	a
T43916	70370-70377	UMLS/C2349977	denotes	studies
T43917	70370-70377	UMLS/C2603343	denotes	studies
T43918	70583-70590	UMLS/C0014406	denotes	ambient
T43919	70648-70655	UMLS/C0935616	denotes	chamber
T43920	70816-70823	UMLS/C0935616	denotes	mber. T
T43921	70479-70490	UMLS/C0348000	denotes	Instruments
T43922	70420-70427	UMLS/C0035953	denotes	running
T43923	70732-70735	UMLS/C0035953	denotes	n u
T43924	70666-70669	UMLS/C0702093	denotes	n t
T43925	70774-70777	UMLS/C0702093	denotes	us
T43926	70856-70859	UMLS/C0702093	denotes	ev
T43927	70868-70871	UMLS/C0702093	denotes	un
T43928	71108-71111	UMLS/C0702093	denotes	du
T43929	70511-70523	UMLS/C0242485	denotes	measurements
T43930	70370-70377	UMLS/C0008976	denotes	studies
T43931	70370-70377	UMLS/C0008972	denotes	studies
T43932	70792-70796	UMLS/C2348395	denotes	d in
T43933	70563-70572	UMLS/C0702240	denotes	elevation
T43934	70860-70865	UMLS/C1948061	denotes	ry 2
T43935	71026-71032	UMLS/C0231175	denotes	led to
T43936	70433-70442	UMLS/C0184069	denotes	treadmill
T43937	70420-70427	UMLS/C0600140	denotes	running
T43938	70732-70735	UMLS/C0600140	denotes	n u
T43939	70666-70669	UMLS/C1552937	denotes	n t
T43940	70774-70777	UMLS/C1552937	denotes	us
T43941	70856-70859	UMLS/C1552937	denotes	ev
T43942	70868-70871	UMLS/C1552937	denotes	un
T43943	71108-71111	UMLS/C1552937	denotes	du
T43944	71094-71100	UMLS/C1522609	denotes	ues ov
T43945	70420-70427	UMLS/C0011991	denotes	running
T43946	70732-70735	UMLS/C0011991	denotes	n u
T43947	70839-70848	UMLS/C0442808	denotes	reased by
T43948	70972-70980	UMLS/C0442808	denotes	rease wi
T43949	70370-70377	UMLS/C0557651	denotes	studies
T43950	70839-70848	UMLS/C0442805	denotes	reased by
T43951	70972-70980	UMLS/C0442805	denotes	rease wi
T43952	70860-70865	UMLS/C1720374	denotes	ry 2
T43953	70462-70468	UMLS/C1704459	denotes	system
T43954	70498-70504	UMLS/C1704459	denotes	System
T43955	70683-70689	UMLS/C1704459	denotes	stem t
T43956	70786-70791	UMLS/C0036974	denotes	ck gr
T43957	71094-71100	UMLS/C1554112	denotes	ues ov
T43958	70609-70616	UMLS/C0003062	denotes	Animals
T43959	70882-70889	UMLS/C0003062	denotes	mals we
T43960	71129-71137	UMLS/C0003062	denotes	mal's O2
T43961	70462-70468	UMLS/C0449913	denotes	system
T43962	70498-70504	UMLS/C0449913	denotes	System
T43963	70683-70689	UMLS/C0449913	denotes	stem t
T43964	70872-70877	UMLS/C1720302	denotes	il th
T43965	71153-71160	UMLS/C0596012	denotes	ched a
T43966	70736-70738	UMLS/C1282910	denotes	a
T43967	70736-70738	UMLS/C1282911	denotes	a
T43968	71064-71074	UMLS/C1443182	denotes	culated us
T43969	70462-70468	UMLS/C1553451	denotes	system
T43970	70498-70504	UMLS/C1553451	denotes	System
T43971	70683-70689	UMLS/C1553451	denotes	stem t
T43972	70760-70765	UMLS/C0678536	denotes	ed of
T43973	70829-70834	UMLS/C0678536	denotes	ed wa
T43974	70527-70545	UMLS/C0030055	denotes	oxygen consumption
T43975	71094-71100	UMLS/C0042295	denotes	ues ov
T43976	71138-71140	UMLS/C0030054	denotes	co
T43977	70452-70456	UMLS/C1882151	denotes	open
T43978	70950-70963	UMLS/C0429627	denotes	gen uptake di
T43979	70638-70647	UMLS/C0311400	denotes	metabolic
T43980	70370-70377	UMLS/C1705923	denotes	studies
T43981	70839-70848	UMLS/C0205217	denotes	reased by
T43982	70972-70980	UMLS/C0205217	denotes	rease wi
T43983	71085-71093	UMLS/C1510992	denotes	raged va
T43984	70452-70456	UMLS/C0175566	denotes	open
T43985	71064-71074	UMLS/C1441506	denotes	culated us
T43986	70721-70728	UMLS/C0205263	denotes	duced t
T43987	70433-70442	UMLS/C2712999	denotes	treadmill
T43988	70666-70669	UMLS/C0439232	denotes	n t
T43989	70774-70777	UMLS/C0439232	denotes	us
T43990	70856-70859	UMLS/C0439232	denotes	ev
T43991	70868-70871	UMLS/C0439232	denotes	un
T43992	71108-71111	UMLS/C0439232	denotes	du
T43993	70622-70633	UMLS/C0332286	denotes	placed into
T43994	70915-70922	UMLS/C0205289	denotes	imal ef
T43995	70580-70581	UMLS/C0439223	denotes	m
T43996	70772-70773	UMLS/C0439223	denotes	i
T43997	70854-70855	UMLS/C0439223	denotes	i
T43998	70580-70581	UMLS/C1552156	denotes	m
T43999	70772-70773	UMLS/C1552156	denotes	i
T44000	70854-70855	UMLS/C1552156	denotes	i
T44001	71036-71044	UMLS/C1314677	denotes	ntain ef
T44002	70563-70572	UMLS/C0439775	denotes	elevation
T44003	71036-71044	UMLS/C0024501	denotes	ntain ef
T44587	71633-71641	UMLS/C1704412	denotes	ontract
T44588	71868-71874	UMLS/C0231530	denotes	witch
T44589	71633-71641	UMLS/C0332522	denotes	ontract
T44590	72327-72335	UMLS/C1522729	denotes	rotocol.
T44591	71633-71641	UMLS/C1548281	denotes	ontract
T44592	71263-71276	UMLS/C0242694	denotes	soleus muscle
T44593	71861-71867	UMLS/C1549113	denotes	ingle
T44594	71741-71745	UMLS/C1272693	denotes	nds
T44595	71914-71923	UMLS/C0205341	denotes	epeating
T44596	71332-71341	UMLS/C1272692	denotes	suspended
T44597	71429-71438	UMLS/C1272692	denotes	suspended
T44598	71308-71315	UMLS/C0015252	denotes	removal
T44599	71741-71745	UMLS/C1561490	denotes	nds
T44600	72258-72262	UMLS/C1550718	denotes	ive
T44601	71924-71930	UMLS/C0040607	denotes	rains
T44602	71985-71990	UMLS/C0040607	denotes	rain
T44603	71198-71205	UMLS/C0947630	denotes	studies
T44604	71198-71205	UMLS/C0557651	denotes	studies
T44605	71526-71533	UMLS/C0454881	denotes	arwick,
T44606	72108-72115	UMLS/C0015672	denotes	atigue
T44607	72319-72326	UMLS/C0015672	denotes	atigue
T44608	71714-71724	UMLS/C0013812	denotes	lectrodes
T44609	71332-71341	UMLS/C1553389	denotes	suspended
T44610	71429-71438	UMLS/C1553389	denotes	suspended
T44611	71592-71597	UMLS/C0302143	denotes	odel
T44612	71667-71672	UMLS/C0302143	denotes	odel
T44613	71246-71254	UMLS/C0043366	denotes	xylazine
T44614	72327-72335	UMLS/C1507394	denotes	rotocol.
T44615	71347-71361	UMLS/C0064411	denotes	Krebs solution
T44616	71409-71423	UMLS/C0064411	denotes	Krebs solution
T44617	72258-72262	UMLS/C1442162	denotes	ive
T44618	71949-71959	UMLS/C0565930	denotes	er second
T44619	71509-71511	UMLS/C0319022	denotes	o
T44620	71630-71632	UMLS/C0319022	denotes	o
T44621	72255-72257	UMLS/C0319022	denotes	o
T44622	71170-71178	UMLS/C0205409	denotes	Isolated
T44623	71500-71508	UMLS/C1624581	denotes	nchored
T44624	72131-72141	UMLS/C0444686	denotes	alculated
T44625	71697-71705	UMLS/C0234402	denotes	timulus
T44626	71875-71882	UMLS/C0234402	denotes	timuli.
T44627	71934-71941	UMLS/C0234402	denotes	timuli
T44628	72116-72126	UMLS/C0683598	denotes	esistance
T44629	72073-72080	UMLS/C1705204	denotes	prings,
T44630	72213-72220	UMLS/C1522410	denotes	ighest
T44631	71206-71213	UMLS/C0003062	denotes	Animals
T44632	72237-72247	UMLS/C1719797	denotes	ultiplied
T44633	71298-71301	UMLS/C0023216	denotes	leg
T44634	71825-71838	UMLS/C1706279	denotes	elationships
T44635	71198-71205	UMLS/C1880229	denotes	studies
T44636	72025-72033	UMLS/C1553414	denotes	ecorded
T44637	71514-71519	UMLS/C0018210	denotes	rass
T44638	71649-71654	UMLS/C0018210	denotes	rass
T44639	71714-71724	UMLS/C1546616	denotes	lectrodes
T44640	71714-71724	UMLS/C1550631	denotes	lectrodes
T44641	72025-72033	UMLS/C1548330	denotes	ecorded
T44642	71332-71341	UMLS/C1553403	denotes	suspended
T44643	71429-71438	UMLS/C1553403	denotes	suspended
T44644	71825-71838	UMLS/C0439849	denotes	elationships
T44645	71991-71997	UMLS/C1517741	denotes	asted
T44646	72185-72189	UMLS/C1517741	denotes	ast
T44647	71580-71590	UMLS/C1705162	denotes	ransducer
T44648	71535-71547	UMLS/C0035487	denotes	hode Island,
T44649	71592-71597	UMLS/C0335295	denotes	odel
T44650	71667-71672	UMLS/C0335295	denotes	odel
T44651	71861-71867	UMLS/C0205171	denotes	ingle
T44652	71633-71641	UMLS/C1705564	denotes	ontract
T44653	71549-71562	UMLS/C0041703	denotes	nited States)
T44654	72092-72105	UMLS/C0041703	denotes	nited States)
T44655	71500-71508	UMLS/C1293132	denotes	nchored
T44656	71294-71297	UMLS/C0205447	denotes	one
T44657	71945-71948	UMLS/C0205447	denotes	ne
T44658	72073-72080	UMLS/C0241232	denotes	prings,
T44659	71298-71301	UMLS/C1140621	denotes	leg
T44660	71170-71178	UMLS/C0370215	denotes	Isolated
T44661	72131-72141	UMLS/C1443182	denotes	alculated
T44662	71904-71913	UMLS/C1705822	denotes	elivered
T44663	71574-71579	UMLS/C0443221	denotes	orce
T44664	71784-71789	UMLS/C0443221	denotes	orce
T44665	72162-72167	UMLS/C0443221	denotes	orce
T44666	72221-72226	UMLS/C0443221	denotes	orce
T44667	72278-72283	UMLS/C0443221	denotes	orce
T44668	72190-72197	UMLS/C0039614	denotes	etanus
T44669	71580-71590	UMLS/C0040661	denotes	ransducer
T44670	71741-71745	UMLS/C0444930	denotes	nds
T44671	72025-72033	UMLS/C2355580	denotes	ecorded
T44672	72025-72033	UMLS/C0557033	denotes	ecorded
T44673	71379-71381	UMLS/C0030054	denotes	O2
T44674	71574-71579	UMLS/C0441722	denotes	orce
T44675	71784-71789	UMLS/C0441722	denotes	orce
T44676	72162-72167	UMLS/C0441722	denotes	orce
T44677	72221-72226	UMLS/C0441722	denotes	orce
T44678	72278-72283	UMLS/C0441722	denotes	orce
T44679	71844-71854	UMLS/C0521095	denotes	etermined
T44680	72258-72262	UMLS/C1947971	denotes	ive
T44681	71714-71724	UMLS/C1705652	denotes	lectrodes
T44682	72267-72274	UMLS/C0439165	denotes	ercent
T44683	72002-72004	UMLS/C2349943	denotes	s,
T44684	72149-72154	UMLS/C1547037	denotes	atio
T44685	71321-71327	UMLS/C1995013	denotes	muscle
T44686	71398-71404	UMLS/C1995013	denotes	muscle
T44687	71489-71495	UMLS/C1995013	denotes	uscle
T44688	71606-71613	UMLS/C1995013	denotes	uscles
T44689	71753-71759	UMLS/C1995013	denotes	uscle.
T44690	71924-71930	UMLS/C1554161	denotes	rains
T44691	71985-71990	UMLS/C1554161	denotes	rain
T44692	71332-71341	UMLS/C0038959	denotes	suspended
T44693	71429-71438	UMLS/C0038959	denotes	suspended
T44694	71198-71205	UMLS/C1705923	denotes	studies
T44695	71741-71745	UMLS/C1522314	denotes	nds
T44696	71170-71178	UMLS/C1546680	denotes	Isolated
T44697	72213-72220	UMLS/C1561958	denotes	ighest
T44698	72213-72220	UMLS/C1561957	denotes	ighest
T44699	71198-71205	UMLS/C2349977	denotes	studies
T44700	72327-72335	UMLS/C2349977	denotes	rotocol.
T44701	71966-71968	UMLS/C0439482	denotes	z
T44702	71924-71930	UMLS/C0336809	denotes	rains
T44703	71985-71990	UMLS/C0336809	denotes	rain
T44704	71574-71579	UMLS/C0563538	denotes	orce
T44705	71784-71789	UMLS/C0563538	denotes	orce
T44706	72162-72167	UMLS/C0563538	denotes	orce
T44707	72221-72226	UMLS/C0563538	denotes	orce
T44708	72278-72283	UMLS/C0563538	denotes	orce
T44709	71825-71838	UMLS/C1705630	denotes	elationships
T44710	71198-71205	UMLS/C2603343	denotes	studies
T44711	72300-72308	UMLS/C1527428	denotes	emained
T44712	71454-71458	UMLS/C0150141	denotes	bath
T44713	71179-71197	UMLS/C1709098	denotes	muscle stimulation
T44714	71691-71696	UMLS/C1553496	denotes	ield
T44715	71924-71930	UMLS/C1552514	denotes	rains
T44716	71985-71990	UMLS/C1552514	denotes	rain
T44717	72309-72314	UMLS/C0687676	denotes	fter
T44718	71619-71629	UMLS/C1948023	denotes	timulated
T44719	71861-71867	UMLS/C0037179	denotes	ingle
T44720	72064-72072	UMLS/C0009399	denotes	olorado
T44721	72082-72090	UMLS/C0009399	denotes	olorado,
T44722	71389-71392	UMLS/C0201930	denotes	CO2
T44723	72051-72062	UMLS/C0348000	denotes	nstruments,
T44724	72213-72220	UMLS/C0205250	denotes	ighest
T44725	72131-72141	UMLS/C1441506	denotes	alculated
T44726	71914-71923	UMLS/C1705914	denotes	epeating
T44727	71924-71930	UMLS/C0220931	denotes	rains
T44728	71985-71990	UMLS/C0220931	denotes	rain
T44729	71975-71978	UMLS/C0702093	denotes	in.
T44730	72327-72335	UMLS/C2348563	denotes	rotocol.
T44731	71924-71930	UMLS/C2673163	denotes	rains
T44732	71985-71990	UMLS/C2673163	denotes	rain
T44733	72327-72335	UMLS/C0442711	denotes	rotocol.
T44734	71975-71978	UMLS/C0439232	denotes	in.
T44735	71198-71205	UMLS/C0008976	denotes	studies
T44736	71198-71205	UMLS/C0008972	denotes	studies
T44737	72149-72154	UMLS/C0456603	denotes	atio
T44738	72198-72205	UMLS/C0332849	denotes	ivided
T44739	71725-71732	UMLS/C0332285	denotes	ocated
T44740	71170-71178	UMLS/C1548221	denotes	Isolated
T44741	71592-71597	UMLS/C0026339	denotes	odel
T44742	71667-71672	UMLS/C0026339	denotes	odel
T44743	71592-71597	UMLS/C0026336	denotes	odel
T44744	71667-71672	UMLS/C0026336	denotes	odel
T44745	71170-71178	UMLS/C1764827	denotes	Isolated
T44746	71776-71783	UMLS/C0205289	denotes	aximal
T44747	72025-72033	UMLS/C0034869	denotes	ecorded
T44748	72002-72004	UMLS/C1552156	denotes	s,
T44749	72002-72004	UMLS/C0439223	denotes	s,
T44750	71592-71597	UMLS/C0870071	denotes	odel
T44751	71667-71672	UMLS/C0870071	denotes	odel
T44752	71308-71315	UMLS/C0728940	denotes	removal
T44753	72309-72314	UMLS/C0231290	denotes	fter
T44754	71219-71231	UMLS/C1720436	denotes	anesthetized
T44755	72149-72154	UMLS/C1610540	denotes	atio
T44756	71298-71301	UMLS/C1269079	denotes	leg
T44757	72284-72294	UMLS/C0079411	denotes	eneration
T44758	71389-71392	UMLS/C0007012	denotes	CO2
T44759	71655-71665	UMLS/C0175727	denotes	timulator
T44760	71888-71898	UMLS/C0175727	denotes	timulator
T44761	71975-71978	UMLS/C1552937	denotes	in.
T44762	71237-71245	UMLS/C0022614	denotes	ketamine
T44763	71281-71293	UMLS/C1292747	denotes	removed from
T44764	72116-72126	UMLS/C0237834	denotes	esistance
T44765	71914-71923	UMLS/C1547730	denotes	epeating
T44766	72213-72220	UMLS/C1299351	denotes	ighest
T44767	72116-72126	UMLS/C1522618	denotes	esistance
T44768	71459-71469	UMLS/C1314677	denotes	maintained
T44769	71521-71525	UMLS/C1705493	denotes	est
T44770	71321-71327	UMLS/C0026845	denotes	muscle
T44771	71398-71404	UMLS/C0026845	denotes	muscle
T44772	71489-71495	UMLS/C0026845	denotes	uscle
T44773	71606-71613	UMLS/C0026845	denotes	uscles
T44774	71753-71759	UMLS/C0026845	denotes	uscle.
T44775	71298-71301	UMLS/C1285009	denotes	leg
T44776	71459-71469	UMLS/C0024501	denotes	maintained
T44777	71691-71696	UMLS/C0440042	denotes	ield
T45156	72363-72368	UMLS/C0001675	denotes	Adult
T45157	72388-72390	UMLS/C0026402	denotes	o
T45158	72337-72345	UMLS/C0015259	denotes	Exercise
T45159	72401-72410	UMLS/C0015259	denotes	ercised o
T45160	72369-72375	UMLS/C0086287	denotes	female
T45161	72598-72607	UMLS/C1706203	denotes	bjected t
T45162	72598-72607	UMLS/C2697811	denotes	bjected t
T45163	72579-72582	UMLS/C0011991	denotes	n,
T45164	72391-72394	UMLS/C0580836	denotes	d)
T45165	72337-72345	UMLS/C1522704	denotes	Exercise
T45166	72401-72410	UMLS/C1522704	denotes	ercised o
T45167	72651-72658	UMLS/C1001332	denotes	quoia E
T45168	72683-72692	UMLS/C0884358	denotes	rformed a
T45169	72509-72519	UMLS/C0392674	denotes	haustion,
T45170	72391-72394	UMLS/C0677546	denotes	d)
T45171	72346-72362	UMLS/C0013516	denotes	echocardiography
T45172	72618-72634	UMLS/C0013516	denotes	hocardiography u
T45173	72659-72675	UMLS/C0013516	denotes	hocardiography S
T45174	72369-72375	UMLS/C0015780	denotes	female
T45175	72676-72682	UMLS/C1704459	denotes	stem p
T45176	72608-72610	UMLS/C0319022	denotes	s
T45177	72543-72554	UMLS/C0205548	denotes	mediately f
T45178	72579-72582	UMLS/C0035953	denotes	n,
T45179	72611-72617	UMLS/C0031082	denotes	rial e
T45180	72475-72484	UMLS/C1552738	denotes	scribed a
T45181	72707-72716	UMLS/C1552738	denotes	scribed [
T45182	72428-72437	UMLS/C2712999	denotes	eadmill u
T45183	72569-72578	UMLS/C2712999	denotes	eadmill r
T45184	72388-72390	UMLS/C0439231	denotes	o
T45185	72555-72564	UMLS/C0332282	denotes	llowing i
T45186	72676-72682	UMLS/C0449913	denotes	stem p
T45187	72555-72564	UMLS/C0332283	denotes	llowing i
T45188	72503-72508	UMLS/C1720302	denotes	til e
T45189	72579-72582	UMLS/C1947934	denotes	n,
T45190	72555-72564	UMLS/C1719822	denotes	llowing i
T45191	72536-72541	UMLS/C0205435	denotes	rst.
T45192	72337-72345	UMLS/C0452240	denotes	Exercise
T45193	72401-72410	UMLS/C0452240	denotes	ercised o
T45194	72598-72607	UMLS/C0681850	denotes	bjected t
T45195	72485-72490	UMLS/C1282910	denotes	ove f
T45196	72676-72682	UMLS/C1553451	denotes	stem p
T45197	72428-72437	UMLS/C0184069	denotes	eadmill u
T45198	72569-72578	UMLS/C0184069	denotes	eadmill r
T45199	72485-72490	UMLS/C1552828	denotes	ove f
T45200	72579-72582	UMLS/C0600140	denotes	n,
T45201	72363-72368	UMLS/C1706450	denotes	Adult
T45202	72369-72375	UMLS/C1705497	denotes	female
T45203	72598-72607	UMLS/C2349001	denotes	bjected t
T45204	72369-72375	UMLS/C1705498	denotes	female
T45205	72683-72692	UMLS/C1550369	denotes	rformed a
T45206	72536-72541	UMLS/C1279901	denotes	rst.
T45207	72598-72607	UMLS/C1550501	denotes	bjected t
T45595	73497-73507	UMLS/C0549178	denotes	pressure-v
T45596	72827-72840	UMLS/C1554963	denotes	modifications
T45597	73279-73291	UMLS/C1269005	denotes	rtic valve.
T45598	73224-73232	UMLS/C1883719	denotes	serted i
T45599	72750-72757	UMLS/C0947630	denotes	studies
T45600	72770-72777	UMLS/C0947630	denotes	studies
T45601	73191-73196	UMLS/C0039711	denotes	xas,
T45602	73648-73653	UMLS/C0039711	denotes	ed St
T45603	72750-72757	UMLS/C0557651	denotes	studies
T45604	72770-72777	UMLS/C0557651	denotes	studies
T45605	73027-73032	UMLS/C0205090	denotes	ght c
T45606	73027-73032	UMLS/C0035621	denotes	ght c
T45607	73610-73616	UMLS/C1704459	denotes	ional
T45608	73152-73160	UMLS/C1704454	denotes	theter (
T45609	73052-73060	UMLS/C0205409	denotes	olated i
T45610	73152-73160	UMLS/C1546572	denotes	theter (
T45611	73618-73626	UMLS/C0015737	denotes	strument
T45612	73011-73021	UMLS/C1547127	denotes	ntilator.
T45613	72827-72840	UMLS/C0392747	denotes	modifications
T45614	72730-72737	UMLS/C0018787	denotes	cardiac
T45615	73152-73160	UMLS/C0520453	denotes	theter (
T45616	73364-73383	UMLS/C0444889	denotes	ntinuous infusion o
T45617	72750-72757	UMLS/C1880229	denotes	studies
T45618	72770-72777	UMLS/C1880229	denotes	studies
T45619	73224-73232	UMLS/C1549539	denotes	serted i
T45620	73323-73331	UMLS/C1553414	denotes	corded a
T45621	73610-73616	UMLS/C0449913	denotes	ional
T45622	73323-73331	UMLS/C1548330	denotes	corded a
T45623	73198-73211	UMLS/C0041703	denotes	ited States),
T45624	73224-73232	UMLS/C1705172	denotes	serted i
T45625	73354-73363	UMLS/C1719822	denotes	llowing c
T45626	73033-73047	UMLS/C0162859	denotes	rotid artery w
T45627	73052-73060	UMLS/C0370215	denotes	olated i
T45628	73027-73032	UMLS/C1552823	denotes	ght c
T45629	73534-73542	UMLS/C0439661	denotes	d digiti
T45630	73335-73343	UMLS/C1552824	denotes	seline a
T45631	73387-73398	UMLS/C1705117	denotes	cremental d
T45632	73610-73616	UMLS/C1553451	denotes	ional
T45633	73242-73256	UMLS/C1269892	denotes	ft ventricle r
T45634	73399-73404	UMLS/C0205448	denotes	ses o
T45635	73033-73047	UMLS/C0007272	denotes	rotid artery w
T45636	73335-73343	UMLS/C0168634	denotes	seline a
T45637	73152-73160	UMLS/C0085590	denotes	theter (
T45638	73323-73331	UMLS/C2355580	denotes	corded a
T45639	73467-73469	UMLS/C0694637	denotes	gB
T45640	73323-73331	UMLS/C0557033	denotes	corded a
T45641	72783-72792	UMLS/C1550369	denotes	performed
T45642	73524-73528	UMLS/C1511726	denotes	cqui
T45643	73593-73597	UMLS/C1511726	denotes	itio
T45644	73011-73021	UMLS/C1611144	denotes	ntilator.
T45645	73224-73232	UMLS/C1743766	denotes	serted i
T45646	73640-73646	UMLS/C0605411	denotes	as, Un
T45647	72857-72862	UMLS/C0001675	denotes	adult
T45648	73279-73291	UMLS/C0003501	denotes	rtic valve.
T45649	72750-72757	UMLS/C1705923	denotes	studies
T45650	72770-72777	UMLS/C1705923	denotes	studies
T45651	73052-73060	UMLS/C1546680	denotes	olated i
T45652	72738-72749	UMLS/C0019010	denotes	hemodynamic
T45653	72758-72769	UMLS/C0019010	denotes	Hemodynamic
T45654	73575-73592	UMLS/C0037585	denotes	ftware data acqui
T45655	72783-72792	UMLS/C0884358	denotes	performed
T45656	72750-72757	UMLS/C2349977	denotes	studies
T45657	72770-72777	UMLS/C2349977	denotes	studies
T45658	73458-73463	UMLS/C0547043	denotes	32 n
T45659	72750-72757	UMLS/C2603343	denotes	studies
T45660	72770-72777	UMLS/C2603343	denotes	studies
T45661	72850-72855	UMLS/C0453896	denotes	brief
T45662	73293-73317	UMLS/C0204901	denotes	modynamic measurements w
T45663	72725-72729	UMLS/C1515655	denotes	vivo
T45664	73169-73180	UMLS/C0348000	denotes	struments,
T45665	73627-73638	UMLS/C0348000	denotes	, Austin, T
T45666	72850-72855	UMLS/C1879313	denotes	brief
T45667	73350-73353	UMLS/C0702093	denotes	n f
T45668	72807-72816	UMLS/C1552738	denotes	described
T45669	73350-73353	UMLS/C0439232	denotes	n f
T45670	72750-72757	UMLS/C0008976	denotes	studies
T45671	72770-72777	UMLS/C0008976	denotes	studies
T45672	72877-72879	UMLS/C0439230	denotes	)
T45673	72750-72757	UMLS/C0008972	denotes	studies
T45674	72770-72777	UMLS/C0008972	denotes	studies
T45675	73011-73021	UMLS/C0087153	denotes	ntilator.
T45676	73354-73363	UMLS/C0332282	denotes	llowing c
T45677	73224-73232	UMLS/C1881216	denotes	serted i
T45678	73242-73256	UMLS/C0225897	denotes	ft ventricle r
T45679	73354-73363	UMLS/C0332283	denotes	llowing c
T45680	73224-73232	UMLS/C1881217	denotes	serted i
T45681	73052-73060	UMLS/C1548221	denotes	olated i
T45682	73027-73032	UMLS/C0140586	denotes	ght c
T45683	73467-73469	UMLS/C0439212	denotes	gB
T45684	73052-73060	UMLS/C1764827	denotes	olated i
T45685	73224-73232	UMLS/C1292748	denotes	serted i
T45686	73323-73331	UMLS/C0034869	denotes	corded a
T45687	73335-73343	UMLS/C1442488	denotes	seline a
T45688	73534-73542	UMLS/C1706701	denotes	d digiti
T45689	73598-73609	UMLS/C1706701	denotes	system (Na
T45690	72886-72898	UMLS/C1720436	denotes	esthetized i
T45691	73257-73267	UMLS/C0439784	denotes	trograde a
T45692	73399-73404	UMLS/C0178602	denotes	ses o
T45693	72857-72862	UMLS/C1706450	denotes	adult
T45694	73350-73353	UMLS/C1552937	denotes	n f
T45695	73408-73418	UMLS/C0012963	denotes	butamine (
T45696	73449-73456	UMLS/C0243192	denotes	st) up
T45697	72927-72944	UMLS/C0936073	denotes	iopental sodium (
T45698	73068-73089	UMLS/C1282036	denotes	gion of the trachea a
T45699	73224-73232	UMLS/C0441587	denotes	serted i
T45700	73399-73404	UMLS/C0453682	denotes	ses o
T45701	73257-73267	UMLS/C0589500	denotes	trograde a
T45702	72730-72737	UMLS/C1522601	denotes	cardiac
T46387	74148-74155	UP/P67971	denotes	lin (pH
T46388	74148-74155	UP/P01328	denotes	lin (pH
T46389	74033-74046	UMLS/C0167250	denotes	solution [11
T46390	74346-74358	UMLS/C0167250	denotes	solution con
T46391	74312-74320	UMLS/C1707719	denotes	ched to
T46392	74148-74155	UP/P30407	denotes	lin (pH
T46393	74387-74392	UMLS/C2349209	denotes	d to
T46394	74148-74155	UP/P04667	denotes	lin (pH
T46395	74387-74392	UMLS/C1145667	denotes	d to
T46396	74685-74691	UMLS/C1704681	denotes	es (Tr
T46397	74148-74155	UP/P01310	denotes	lin (pH
T46398	73845-73851	UMLS/C0377674	denotes	) 10 m
T46399	74148-74155	UP/P29335	denotes	lin (pH
T46400	74255-74261	UMLS/C0025663	denotes	od. Fo
T46401	73775-73784	UMLS/C0025664	denotes	procedure
T46402	74255-74261	UMLS/C0025664	denotes	od. Fo
T46403	73670-73677	UMLS/C1563350	denotes	working
T46404	73709-73716	UMLS/C1563350	denotes	working
T46405	74328-74335	UMLS/C1563350	denotes	ing mod
T46406	74921-74925	UMLS/C1563350	denotes	was
T46407	74685-74691	UMLS/C0182400	denotes	es (Tr
T46408	73670-73677	UMLS/C1563351	denotes	working
T46409	73709-73716	UMLS/C1563351	denotes	working
T46410	74328-74335	UMLS/C1563351	denotes	ing mod
T46411	74921-74925	UMLS/C1563351	denotes	was
T46412	74285-74296	UMLS/C0917707	denotes	ulation, pe
T46413	74948-74955	UMLS/C1514468	denotes	uct of
T46414	73845-73851	UMLS/C1522712	denotes	) 10 m
T46415	73982-73988	UMLS/C1882509	denotes	ed in
T46416	74273-74277	UMLS/C0205091	denotes	atr
T46417	74606-74623	UMLS/C0871470	denotes	olic pressure, an
T46418	74964-74981	UMLS/C0871470	denotes	olic pressure and
T46419	74148-74155	UP/Q62587	denotes	lin (pH
T46420	73743-73748	UMLS/C1880279	denotes	based
T46421	73812-73815	UMLS/C0677546	denotes	d)
T46422	74336-74340	UMLS/C2347637	denotes	wit
T46423	73895-73914	UMLS/C0475747	denotes	eply anesthetized w
T46424	73933-73939	UMLS/C0037473	denotes	um pen
T46425	74321-74323	UMLS/C0319022	denotes	he
T46426	74393-74395	UMLS/C0319022	denotes	%
T46427	74148-74155	UP/P51463	denotes	lin (pH
T46428	74336-74340	UMLS/C1513371	denotes	wit
T46429	74148-74155	UP/P69045	denotes	lin (pH
T46430	73865-73875	UMLS/C0278134	denotes	esthesia.
T46431	74148-74155	UP/P01340	denotes	lin (pH
T46432	74148-74155	UP/P01314	denotes	lin (pH
T46433	74930-74940	UMLS/C0444686	denotes	ulated as
T46434	74148-74155	UP/P68245	denotes	lin (pH
T46435	74020-74031	UMLS/C0005367	denotes	rbonate (KH
T46436	74148-74155	UP/P12704	denotes	lin (pH
T46437	74571-74585	UMLS/C0007165	denotes	iac output, ao
T46438	73856-73864	UMLS/C0332152	denotes	ior to a
T46439	74148-74155	UP/Q91XI3	denotes	lin (pH
T46440	74148-74155	UP/P01336	denotes	lin (pH
T46441	74148-74155	UP/P68243	denotes	lin (pH
T46442	74148-74155	UP/Q8HXV2	denotes	lin (pH
T46443	74454-74456	UMLS/C2348272	denotes	nd
T46444	74492-74494	UMLS/C2348272	denotes	or
T46445	74434-74442	UMLS/C0460139	denotes	sure of
T46446	74474-74482	UMLS/C0460139	denotes	sure of
T46447	74148-74155	UP/Q9NDE7	denotes	lin (pH
T46448	74148-74155	UP/P01324	denotes	lin (pH
T46449	74730-74743	UMLS/C0041703	denotes	ed States), a
T46450	74822-74835	UMLS/C0041703	denotes	ed States) an
T46451	73775-73784	UMLS/C0184661	denotes	procedure
T46452	74387-74392	UMLS/C1167622	denotes	d to
T46453	74148-74155	UP/P09476	denotes	lin (pH
T46454	74055-74059	UMLS/C0037494	denotes	, 25
T46455	73933-73939	UMLS/C0037570	denotes	um pen
T46456	74594-74599	UMLS/C0806140	denotes	s, pe
T46457	74680-74684	UMLS/C0806140	denotes	pro
T46458	74748-74767	UMLS/C0040662	denotes	sure transducer (TS
T46459	74148-74155	UMLS/C1337112	denotes	lin (pH
T46460	73865-73875	UMLS/C1546907	denotes	esthesia.
T46461	74415-74418	UMLS/C1511233	denotes	wit
T46462	73791-73796	UMLS/C0001675	denotes	Adult
T46463	74529-74537	UMLS/C0037633	denotes	tion. Fu
T46464	74148-74155	UP/Q6YK33	denotes	lin (pH
T46465	74148-74155	UP/P12703	denotes	lin (pH
T46466	74629-74639	UMLS/C0488794	denotes	t rate wer
T46467	73743-73748	UMLS/C0178499	denotes	based
T46468	73661-73669	UMLS/C1546680	denotes	Isolated
T46469	73700-73708	UMLS/C1546680	denotes	Isolated
T46470	74148-74155	UP/P17715	denotes	lin (pH
T46471	74148-74155	UP/P01319	denotes	lin (pH
T46472	74148-74155	UP/P01331	denotes	lin (pH
T46473	74415-74418	UMLS/C0036774	denotes	wit
T46474	74685-74691	UMLS/C0728863	denotes	es (Tr
T46475	73684-73689	UMLS/C1281570	denotes	heart
T46476	73723-73728	UMLS/C1281570	denotes	heart
T46477	73958-73964	UMLS/C1281570	denotes	ts wer
T46478	74167-74173	UMLS/C1281570	denotes	ts wer
T46479	73933-73939	UMLS/C0597484	denotes	um pen
T46480	74157-74159	UMLS/C0450407	denotes	.4
T46481	74157-74159	UMLS/C0450408	denotes	.4
T46482	74055-74059	UMLS/C1959973	denotes	, 25
T46483	74157-74159	UMLS/C0450409	denotes	.4
T46484	74148-74155	UP/P07453	denotes	lin (pH
T46485	74720-74728	UMLS/C0027976	denotes	York, Un
T46486	74157-74159	UMLS/C2363150	denotes	.4
T46487	74148-74155	UP/P01320	denotes	lin (pH
T46488	74157-74159	UMLS/C0031526	denotes	.4
T46489	73775-73784	UMLS/C1948041	denotes	procedure
T46490	74148-74155	UP/Q9W7R2	denotes	lin (pH
T46491	73933-73939	UMLS/C0337443	denotes	um pen
T46492	74529-74537	UMLS/C1382100	denotes	tion. Fu
T46493	74502-74505	UMLS/C0702093	denotes	wit
T46494	74415-74418	UMLS/C0005902	denotes	wit
T46495	74196-74209	UMLS/C0442339	denotes	the aorta and
T46496	74148-74155	UP/P69047	denotes	lin (pH
T46497	74148-74155	UP/P41522	denotes	lin (pH
T46498	74148-74155	UMLS/C0021641	denotes	lin (pH
T46499	73743-73748	UMLS/C1704464	denotes	based
T46500	74148-74155	UP/Q98TA8	denotes	lin (pH
T46501	74148-74155	UP/P68992	denotes	lin (pH
T46502	73670-73677	UMLS/C0043227	denotes	working
T46503	73709-73716	UMLS/C0043227	denotes	working
T46504	74328-74335	UMLS/C0043227	denotes	ing mod
T46505	74921-74925	UMLS/C0043227	denotes	was
T46506	74148-74155	UP/P21563	denotes	lin (pH
T46507	73839-73844	UMLS/C2347274	denotes	its I
T46508	74140-74145	UMLS/C2347274	denotes	s/L i
T46509	74148-74155	UP/P67973	denotes	lin (pH
T46510	74148-74155	UP/P69046	denotes	lin (pH
T46511	74148-74155	UP/P67969	denotes	lin (pH
T46512	74654-74659	UMLS/C1948061	denotes	y 10
T46513	74148-74155	UP/P68987	denotes	lin (pH
T46514	74645-74653	UMLS/C1706701	denotes	ired eve
T46515	74846-74854	UMLS/C1706701	denotes	ired wit
T46516	74148-74155	UP/P01334	denotes	lin (pH
T46517	74502-74505	UMLS/C1552937	denotes	wit
T46518	74157-74159	UMLS/C1304686	denotes	.4
T46519	74336-74340	UMLS/C1705738	denotes	wit
T46520	74148-74155	UP/P01315	denotes	lin (pH
T46521	74948-74955	UMLS/C1550506	denotes	uct of
T46522	74148-74155	UP/P18109	denotes	lin (pH
T46523	74769-74772	UMLS/C0039373	denotes	104
T46524	74913-74920	UMLS/C1522601	denotes	iac wor
T46525	73865-73875	UMLS/C0002930	denotes	esthesia.
T46526	74410-74414	UMLS/C1996904	denotes	BSA
T46527	74539-74562	UMLS/C0940836	denotes	tional measurements, na
T46528	74629-74639	UMLS/C0018810	denotes	t rate wer
T46529	74399-74409	UMLS/C0015684	denotes	y acid-fre
T46530	74148-74155	UP/P67972	denotes	lin (pH
T46531	74123-74130	UMLS/C0017725	denotes	ose, an
T46532	73849-73855	UMLS/C0456692	denotes	min p
T46533	74660-74666	UMLS/C0456692	denotes	in usi
T46534	74157-74159	UMLS/C0020283	denotes	.4
T46535	74148-74155	UP/P68988	denotes	lin (pH
T46536	74148-74155	UP/P01318	denotes	lin (pH
T46537	74654-74659	UMLS/C1720374	denotes	y 10
T46538	74148-74155	UP/P12708	denotes	lin (pH
T46539	74685-74691	UMLS/C0419358	denotes	es (Tr
T46540	74148-74155	UP/P81881	denotes	lin (pH
T46541	73775-73784	UMLS/C0945766	denotes	procedure
T46542	74278-74284	UMLS/C0018792	denotes	al can
T46543	74948-74955	UMLS/C1704444	denotes	uct of
T46544	74148-74155	UP/P68991	denotes	lin (pH
T46545	73839-73844	UMLS/C1519795	denotes	its I
T46546	74140-74145	UMLS/C1519795	denotes	s/L i
T46547	74148-74155	UP/P01321	denotes	lin (pH
T46548	74703-74710	UMLS/C1704459	denotes	ems, It
T46549	74786-74793	UMLS/C1704459	denotes	ems, Sa
T46550	74870-74876	UMLS/C1704459	denotes	em fro
T46551	74903-74910	UMLS/C1704459	denotes	ems). C
T46552	73865-73875	UMLS/C0002903	denotes	esthesia.
T46553	74148-74155	UP/Q9TQY7	denotes	lin (pH
T46554	74148-74155	UMLS/C0202098	denotes	lin (pH
T46555	74148-74155	UP/P01342	denotes	lin (pH
T46556	74148-74155	UP/O73727	denotes	lin (pH
T46557	73670-73677	UMLS/C0557351	denotes	working
T46558	73709-73716	UMLS/C0557351	denotes	working
T46559	74328-74335	UMLS/C0557351	denotes	ing mod
T46560	74921-74925	UMLS/C0557351	denotes	was
T46561	73661-73669	UMLS/C0205409	denotes	Isolated
T46562	73700-73708	UMLS/C0205409	denotes	Isolated
T46563	73839-73844	UMLS/C1704434	denotes	its I
T46564	74140-74145	UMLS/C1704434	denotes	s/L i
T46565	74387-74392	UMLS/C1689898	denotes	d to
T46566	73684-73689	UMLS/C0018787	denotes	heart
T46567	73723-73728	UMLS/C0018787	denotes	heart
T46568	73958-73964	UMLS/C0018787	denotes	ts wer
T46569	74167-74173	UMLS/C0018787	denotes	ts wer
T46570	74913-74920	UMLS/C0018787	denotes	iac wor
T46571	73743-73748	UMLS/C1549548	denotes	based
T46572	73877-73884	UMLS/C0003062	denotes	imals w
T46573	74214-74222	UMLS/C1549542	denotes	used ret
T46574	74810-74820	UMLS/C0006754	denotes	fornia, Un
T46575	74148-74155	UP/P01317	denotes	lin (pH
T46576	74703-74710	UMLS/C0449913	denotes	ems, It
T46577	74786-74793	UMLS/C0449913	denotes	ems, Sa
T46578	74870-74876	UMLS/C0449913	denotes	em fro
T46579	74903-74910	UMLS/C0449913	denotes	ems). C
T46580	74434-74442	UMLS/C0033095	denotes	sure of
T46581	74474-74482	UMLS/C0033095	denotes	sure of
T46582	73743-73748	UMLS/C1626935	denotes	based
T46583	74410-74414	UMLS/C1880497	denotes	BSA
T46584	74263-74272	UMLS/C1719822	denotes	owing lef
T46585	74190-74195	UMLS/C0205435	denotes	t via
T46586	73661-73669	UMLS/C0370215	denotes	Isolated
T46587	73700-73708	UMLS/C0370215	denotes	Isolated
T46588	74930-74940	UMLS/C1443182	denotes	ulated as
T46589	74645-74653	UMLS/C0439661	denotes	ired eve
T46590	74846-74854	UMLS/C0439661	denotes	ired wit
T46591	74703-74710	UMLS/C1553451	denotes	ems, It
T46592	74786-74793	UMLS/C1553451	denotes	ems, Sa
T46593	74870-74876	UMLS/C1553451	denotes	em fro
T46594	74903-74910	UMLS/C1553451	denotes	ems). C
T46595	74273-74277	UMLS/C1552822	denotes	atr
T46596	74148-74155	UP/P01316	denotes	lin (pH
T46597	74529-74537	UMLS/C2699488	denotes	tion. Fu
T46598	73743-73748	UMLS/C1550601	denotes	based
T46599	74864-74869	UMLS/C1417779	denotes	0 sys
T46600	74434-74442	UMLS/C1306345	denotes	sure of
T46601	74474-74482	UMLS/C1306345	denotes	sure of
T46602	74123-74130	UMLS/C0337438	denotes	ose, an
T46603	74148-74155	UP/P30406	denotes	lin (pH
T46604	74148-74155	UP/P01308	denotes	lin (pH
T46605	74255-74261	UMLS/C0449851	denotes	od. Fo
T46606	74148-74155	UP/P01333	denotes	lin (pH
T46607	74148-74155	UP/P01339	denotes	lin (pH
T46608	74190-74195	UMLS/C1279901	denotes	t via
T46609	74148-74155	UP/P09477	denotes	lin (pH
T46610	74841-74845	UMLS/C1511726	denotes	acq
T46611	73839-73844	UMLS/C1880519	denotes	its I
T46612	74140-74145	UMLS/C1880519	denotes	s/L i
T46613	74148-74155	UP/P01311	denotes	lin (pH
T46614	73809-73811	UMLS/C0026402	denotes	o
T46615	74148-74155	UP/P01335	denotes	lin (pH
T46616	74522-74528	UMLS/C0006353	denotes	er sol
T46617	74415-74418	UMLS/C0487992	denotes	wit
T46618	74685-74691	UMLS/C2347609	denotes	es (Tr
T46619	74454-74456	UMLS/C0025424	denotes	nd
T46620	74492-74494	UMLS/C0025424	denotes	or
T46621	73690-73699	UMLS/C0031001	denotes	perfusion
T46622	73729-73738	UMLS/C0031001	denotes	perfusion
T46623	74298-74307	UMLS/C0031001	denotes	usion was
T46624	74148-74155	UP/P67974	denotes	lin (pH
T46625	74377-74386	UMLS/C0030233	denotes	itate bou
T46626	73812-73815	UMLS/C0580836	denotes	d)
T46627	73839-73844	UMLS/C0439148	denotes	its I
T46628	74140-74145	UMLS/C0439148	denotes	s/L i
T46629	74587-74593	UMLS/C0003483	denotes	ic flo
T46630	74148-74155	UP/P67970	denotes	lin (pH
T46631	74148-74155	UP/P81025	denotes	lin (pH
T46632	73743-73748	UMLS/C1705938	denotes	based
T46633	73775-73784	UMLS/C2700391	denotes	procedure
T46634	74529-74537	UMLS/C0525069	denotes	tion. Fu
T46635	74148-74155	UP/P67968	denotes	lin (pH
T46636	74148-74155	UP/P81423	denotes	lin (pH
T46637	74148-74155	UP/P12705	denotes	lin (pH
T46638	74148-74155	UP/P06306	denotes	lin (pH
T46639	74148-74155	UP/P13190	denotes	lin (pH
T46640	74387-74392	UMLS/C0243122	denotes	d to
T46641	74359-74369	UMLS/C1549781	denotes	aining 1.2
T46642	74067-74073	UMLS/C0074722	denotes	O3, 4.
T46643	74148-74155	UP/P68989	denotes	lin (pH
T46644	74930-74940	UMLS/C1441506	denotes	ulated as
T46645	74810-74820	UMLS/C0324542	denotes	fornia, Un
T46646	74454-74456	UMLS/C2347108	denotes	nd
T46647	74492-74494	UMLS/C2347108	denotes	or
T46648	74148-74155	UP/P01329	denotes	lin (pH
T46649	74148-74155	UP/P69048	denotes	lin (pH
T46650	74359-74369	UMLS/C2700400	denotes	aining 1.2
T46651	74685-74691	UMLS/C1442917	denotes	es (Tr
T46652	74601-74614	UMLS/C0442710	denotes	systolic pre
T46653	74959-74972	UMLS/C0442710	denotes	systolic pre
T46654	74410-74414	UMLS/C0332296	denotes	BSA
T46655	74148-74155	UP/P01330	denotes	lin (pH
T46656	74454-74456	UMLS/C2347109	denotes	nd
T46657	74492-74494	UMLS/C2347109	denotes	or
T46658	73765-73774	UMLS/C1552738	denotes	described
T46659	74148-74155	UMLS/C1145751	denotes	lin (pH
T46660	74502-74505	UMLS/C0439232	denotes	wit
T46661	74020-74031	UMLS/C0202059	denotes	rbonate (KH
T46662	73809-73811	UMLS/C0439231	denotes	o
T46663	74148-74155	UP/P01313	denotes	lin (pH
T46664	74148-74155	UP/P30410	denotes	lin (pH
T46665	74263-74272	UMLS/C0332282	denotes	owing lef
T46666	74415-74418	UP/P02769	denotes	wit
T46667	74263-74272	UMLS/C0332283	denotes	owing lef
T46668	73661-73669	UMLS/C1548221	denotes	Isolated
T46669	73700-73708	UMLS/C1548221	denotes	Isolated
T46670	73775-73784	UMLS/C1546467	denotes	procedure
T46671	73982-73988	UMLS/C1704765	denotes	ed in
T46672	73940-73953	UMLS/C0030883	denotes	obarbital IP.
T46673	73661-73669	UMLS/C1764827	denotes	Isolated
T46674	73700-73708	UMLS/C1764827	denotes	Isolated
T46675	74123-74130	UMLS/C0202042	denotes	ose, an
T46676	74359-74369	UMLS/C0332256	denotes	aining 1.2
T46677	74148-74155	UP/P0C236	denotes	lin (pH
T46678	74148-74155	UMLS/C1533581	denotes	lin (pH
T46679	73839-73844	UMLS/C1704753	denotes	its I
T46680	74140-74145	UMLS/C1704753	denotes	s/L i
T46681	74148-74155	UP/P42633	denotes	lin (pH
T46682	73791-73796	UMLS/C1706450	denotes	Adult
T46683	74148-74155	UMLS/C1579433	denotes	lin (pH
T46684	74148-74155	UP/P01327	denotes	lin (pH
T46685	74336-74340	UMLS/C2348146	denotes	wit
T46686	74148-74155	UP/P68990	denotes	lin (pH
T47329	75457-75467	UMLS/C0456081	denotes	djustment
T47330	75100-75107	UMLS/C1555716	denotes	battery
T47331	75191-75195	UMLS/C1704970	denotes	mean
T47332	75807-75818	UMLS/C1707455	denotes	omparisons
T47333	75206-75209	UMLS/C0262878	denotes	EM,
T47334	75624-75632	UMLS/C0332516	denotes	ymmetry
T47335	75114-75119	UMLS/C0456079	denotes	level
T47336	75477-75483	UMLS/C0456079	denotes	evels
T47337	75550-75556	UMLS/C0456079	denotes	evels,
T47338	75769-75775	UMLS/C0456079	denotes	evels
T47339	75401-75409	UMLS/C0205341	denotes	epeated
T47340	75123-75135	UMLS/C0750502	denotes	significance
T47341	75066-75073	UMLS/C1553889	denotes	general
T47342	75191-75195	UMLS/C2347634	denotes	mean
T47343	75035-75042	UMLS/C0871472	denotes	T-tests
T47344	75677-75685	UMLS/C1883712	denotes	ddition,
T47345	75578-75585	UMLS/C0521124	denotes	gainst
T47346	75561-75566	UMLS/C1705175	denotes	rder
T47347	75245-75250	UMLS/C0302143	denotes	odel
T47348	75667-75672	UMLS/C0302143	denotes	odel.
T47349	75561-75566	UMLS/C1705177	denotes	rder
T47350	75561-75566	UMLS/C1705176	denotes	rder
T47351	75561-75566	UMLS/C1705178	denotes	rder
T47352	75285-75289	UMLS/C0183885	denotes	est
T47353	75179-75187	UMLS/C1709908	denotes	reported
T47354	75054-75062	UMLS/C0444706	denotes	measures
T47355	75410-75418	UMLS/C0444706	denotes	easures
T47356	75163-75168	UMLS/C1533148	denotes	cases
T47357	75256-75258	UMLS/C0319022	denotes	o
T47358	75567-75569	UMLS/C0319022	denotes	o
T47359	75735-75737	UMLS/C0319022	denotes	o
T47360	75536-75540	UMLS/C0439064	denotes	ore
T47361	75798-75806	UMLS/C0439064	denotes	ultiple
T47362	75140-75143	UMLS/C1552652	denotes	set
T47363	74999-75009	UMLS/C2348149	denotes	Statistics
T47364	75163-75168	UMLS/C0868928	denotes	cases
T47365	75723-75734	UMLS/C1548787	denotes	ppropriate
T47366	75140-75143	UMLS/C1705195	denotes	set
T47367	75074-75082	UMLS/C0441655	denotes	activity
T47368	75054-75062	UMLS/C0079809	denotes	measures
T47369	75410-75418	UMLS/C0079809	denotes	easures
T47370	75196-75202	UMLS/C1554112	denotes	values
T47371	75285-75289	UMLS/C0392366	denotes	est
T47372	75320-75328	UMLS/C0439828	denotes	ariable
T47373	75365-75373	UMLS/C0439828	denotes	ariable
T47374	75738-75742	UMLS/C1552861	denotes	elp
T47375	75140-75143	UMLS/C1318139	denotes	set
T47376	75290-75298	UMLS/C1552866	denotes	ncluded
T47377	75196-75202	UMLS/C1704610	denotes	values
T47378	75536-75540	UMLS/C0205172	denotes	ore
T47379	74999-75009	UMLS/C0600673	denotes	Statistics
T47380	75245-75250	UMLS/C0335295	denotes	odel
T47381	75667-75672	UMLS/C0335295	denotes	odel.
T47382	75471-75476	UMLS/C0439095	denotes	lpha
T47383	75763-75768	UMLS/C0439095	denotes	lpha
T47384	75285-75289	UMLS/C0039593	denotes	est
T47385	75698-75708	UMLS/C1705565	denotes	orrection
T47386	75299-75302	UMLS/C0205447	denotes	ne
T47387	75345-75348	UMLS/C0205447	denotes	ne
T47388	75285-75289	UMLS/C0013702	denotes	est
T47389	75228-75233	UMLS/C1317574	denotes	oted.
T47390	75100-75107	UMLS/C0337088	denotes	battery
T47391	75546-75549	UMLS/C0205448	denotes	wo
T47392	75330-75338	UMLS/C1285573	denotes	enotype)
T47393	75046-75052	UMLS/C1334891	denotes	ANOVAs
T47394	75239-75244	UMLS/C1334891	denotes	NOVA
T47395	75389-75395	UMLS/C1334891	denotes	NOVAs
T47396	75661-75666	UMLS/C1334891	denotes	NOVA
T47397	75457-75467	UMLS/C0376209	denotes	djustment
T47398	75100-75107	UMLS/C0542351	denotes	battery
T47399	75285-75289	UMLS/C0022885	denotes	est
T47400	75196-75202	UMLS/C0042295	denotes	values
T47401	75010-75014	UMLS/C1511726	denotes	Data
T47402	75170-75174	UMLS/C1511726	denotes	Data
T47403	75698-75708	UMLS/C1947976	denotes	orrection
T47404	75074-75082	UMLS/C1561536	denotes	activity
T47405	75424-75433	UMLS/C1267211	denotes	onducted,
T47406	75824-75833	UMLS/C1267211	denotes	onducted.
T47407	75457-75467	UMLS/C1546424	denotes	djustment
T47408	75074-75082	UMLS/C0439167	denotes	activity
T47409	75424-75433	UMLS/C0441247	denotes	onducted,
T47410	75824-75833	UMLS/C0441247	denotes	onducted.
T47411	75424-75433	UMLS/C0337115	denotes	onducted,
T47412	75824-75833	UMLS/C0337115	denotes	onducted.
T47413	75179-75187	UMLS/C0700287	denotes	reported
T47414	75320-75328	UMLS/C1705098	denotes	ariable
T47415	75365-75373	UMLS/C1705098	denotes	ariable
T47416	75020-75028	UMLS/C0936012	denotes	analyzed
T47417	75259-75266	UMLS/C0936012	denotes	nalyze
T47418	75752-75762	UMLS/C0278329	denotes	rescribed
T47419	75561-75566	UMLS/C1546465	denotes	rder
T47420	75191-75195	UMLS/C0876919	denotes	mean
T47421	75525-75535	UMLS/C1549781	denotes	ontaining
T47422	75066-75073	UMLS/C0205246	denotes	general
T47423	75401-75409	UMLS/C1705914	denotes	epeated
T47424	75290-75298	UMLS/C2700399	denotes	ncluded
T47425	75525-75535	UMLS/C2700400	denotes	ontaining
T47426	75054-75062	UMLS/C0242485	denotes	measures
T47427	75410-75418	UMLS/C0242485	denotes	easures
T47428	75624-75632	UMLS/C0439711	denotes	ymmetry
T47429	75517-75524	UMLS/C1280500	denotes	ffects
T47430	75375-75381	UMLS/C0008976	denotes	rials)
T47431	75140-75143	UMLS/C1442518	denotes	set
T47432	75100-75107	UMLS/C1704779	denotes	battery
T47433	75140-75143	UMLS/C0001774	denotes	set
T47434	75123-75135	UMLS/C0237881	denotes	significance
T47435	75163-75168	UMLS/C1706256	denotes	cases
T47436	75424-75433	UMLS/C0004927	denotes	onducted,
T47437	75824-75833	UMLS/C0004927	denotes	onducted.
T47438	74999-75009	UMLS/C0038215	denotes	Statistics
T47439	75245-75250	UMLS/C0026339	denotes	odel
T47440	75667-75672	UMLS/C0026339	denotes	odel.
T47441	75245-75250	UMLS/C0026336	denotes	odel
T47442	75667-75672	UMLS/C0026336	denotes	odel.
T47443	75290-75298	UMLS/C0332257	denotes	ncluded
T47444	75525-75535	UMLS/C0332256	denotes	ontaining
T47445	75245-75250	UMLS/C0870071	denotes	odel
T47446	75667-75672	UMLS/C0870071	denotes	odel.
T47447	75517-75524	UMLS/C2348382	denotes	ffects
T47448	75140-75143	UMLS/C0036849	denotes	set
T47449	75330-75338	UMLS/C0017431	denotes	enotype)
T47450	75046-75052	UMLS/C1367971	denotes	ANOVAs
T47451	75239-75244	UMLS/C1367971	denotes	NOVA
T47452	75389-75395	UMLS/C1367971	denotes	NOVAs
T47453	75661-75666	UMLS/C1367971	denotes	NOVA
T47454	75401-75409	UMLS/C1547730	denotes	epeated
T47455	75743-75751	UMLS/C1314677	denotes	aintain
T47456	75561-75566	UMLS/C1882348	denotes	rder
T47457	75054-75062	UMLS/C1879489	denotes	measures
T47458	75410-75418	UMLS/C1879489	denotes	easures
T47459	75114-75119	UMLS/C0441889	denotes	level
T47460	75477-75483	UMLS/C0441889	denotes	evels
T47461	75550-75556	UMLS/C0441889	denotes	evels,
T47462	75769-75775	UMLS/C0441889	denotes	evels
T47463	75457-75467	UMLS/C0683269	denotes	djustment
T47464	75140-75143	UMLS/C1552685	denotes	set
T47465	75196-75202	UMLS/C1522609	denotes	values
T47466	75191-75195	UMLS/C2348143	denotes	mean
T47467	75140-75143	UMLS/C0542559	denotes	set
T47468	75206-75209	UMLS/C0432222	denotes	EM,
T47469	75046-75052	UMLS/C0002780	denotes	ANOVAs
T47470	75239-75244	UMLS/C0002780	denotes	NOVA
T47471	75389-75395	UMLS/C0002780	denotes	NOVAs
T47472	75661-75666	UMLS/C0002780	denotes	NOVA
T47473	75191-75195	UMLS/C0444504	denotes	mean
T47474	75743-75751	UMLS/C0024501	denotes	aintain
T47475	75656-75660	UMLS/C0323983	denotes	his
T47476	75698-75708	UMLS/C1546923	denotes	orrection
T36478	61353-61362	UMLS/C0884358	denotes	erformed
T23696	41468-41499	UP/Q28115	denotes	in, failed to show an increase
T23714	41468-41499	UP/P14136	denotes	in, failed to show an increase
T23795	41309-41313	UMLS/C0205125	denotes	bral
T9460	15494-15506	UP/Q6QLW4	denotes	idase IV) an
T38793	64121-64128	UP/P67971	denotes	Insulin
T2913	4271-4300	UP/Q90X44	denotes	y factors 1 and 2 (NRF-1 and
T21821	38484-38491	UP/P67971	denotes	n-resis
T21867	39750-39757	UP/Q62587	denotes	B). Tak
T19421	37359-37382	UP/O00767	denotes	mice (Table 2). Furthe
T19746	32660-32668	UMLS/C0370215	denotes	C-1α−/−

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T636	1544-1550	PR_EXT:000013059	denotes	PGC-1α
T637	0-6	PR_EXT:000013059	denotes	PGC-1α
T638	31-37	UBERON:0000467	denotes	System
T639	45-54	GO:0008152	denotes	Metabolic
T640	69-75	UBERON_EXT:muscle_structure_or_tissue	denotes	Muscle
T641	105-112	GO:0065007	denotes	Control
T642	117-124	UBERON:0002107	denotes	Hepatic
T643	193-197	SO_EXT:0000704	denotes	gene
T644	198-206	SO_EXT:sequence_coding_function	denotes	encoding
T645	211-226	GO_EXT:transcription	denotes	transcriptional
T646	211-238	GO_EXT:0003713	denotes	transcriptional coactivator
T647	239-249	GO:0005777	denotes	peroxisome
T648	239-298	PR_EXT:000013059	denotes	peroxisome proliferator-activated receptor-γ coactivator-1α
T649	273-281	GO_EXT:0004872	denotes	receptor
T650	300-306	PR_EXT:000013059	denotes	PGC-1α
T651	324-328	NCBITaxon:10088	denotes	mice
T652	330-336	PR_EXT:000013059	denotes	PGC-1α
T653	337-341	SO_EXT:sequence_nullness	denotes	null
T654	343-349	PR_EXT:000013059	denotes	PGC-1α
T655	349-350	SO_EXT:sequence_nullness_or_absence	denotes	−
T656	351-352	SO_EXT:sequence_nullness_or_absence	denotes	−
T657	354-358	NCBITaxon:10088	denotes	mice
T658	418-424	UBERON:0000467	denotes	system
T659	472-481	GO:0008152	denotes	metabolic
T660	501-506	GO:0007567	denotes	natal
T661	507-513	GO_EXT:biological_growth_entity_or_process	denotes	growth
T662	517-522	UBERON:0000948	denotes	heart
T663	527-554	UBERON:0006907	denotes	slow-twitch skeletal muscle
T664	556-562	UBERON:0000062	denotes	organs
T665	573-586	GO:0005739	denotes	mitochondrial
T666	617-623	PR_EXT:000013059	denotes	PGC-1α
T667	623-624	SO_EXT:sequence_nullness_or_absence	denotes	−
T668	625-626	SO_EXT:sequence_nullness_or_absence	denotes	−
T669	627-631	NCBITaxon:10088	denotes	mice
T670	647-653	PR_EXT:000013059	denotes	PGC-1α
T671	653-654	SO_EXT:sequence_nullness_or_absence	denotes	−
T672	655-656	SO_EXT:sequence_nullness_or_absence	denotes	−
T673	657-661	NCBITaxon:10088	denotes	mice
T674	691-695	UBERON_EXT:body	denotes	body
T675	696-699	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T676	736-743	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T677	745-758	GO:0005739	denotes	Mitochondrial
T678	770-781	GO:0045333	denotes	respiratory
T679	808-835	UBERON:0006907	denotes	slow-twitch skeletal muscle
T680	839-845	PR_EXT:000013059	denotes	PGC-1α
T681	845-846	SO_EXT:sequence_nullness_or_absence	denotes	−
T682	847-848	SO_EXT:sequence_nullness_or_absence	denotes	−
T683	849-853	NCBITaxon:10088	denotes	mice
T684	874-880	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T685	916-922	PR_EXT:000013059	denotes	PGC-1α
T686	922-923	SO_EXT:sequence_nullness_or_absence	denotes	−
T687	924-925	SO_EXT:sequence_nullness_or_absence	denotes	−
T688	926-930	NCBITaxon:10088	denotes	mice
T689	962-969	UBERON:0000948	denotes	cardiac
T690	1007-1028	GO:0002027	denotes	control of heart rate
T691	1018-1023	UBERON:0000948	denotes	heart
T692	1034-1040	PR_EXT:000013059	denotes	PGC-1α
T693	1040-1041	SO_EXT:sequence_nullness_or_absence	denotes	−
T694	1042-1043	SO_EXT:sequence_nullness_or_absence	denotes	−
T695	1044-1048	NCBITaxon:10088	denotes	mice
T696	1078-1082	UBERON_EXT:body	denotes	body
T697	1150-1161	GO:0031649	denotes	thermogenic
T698	1162-1170	GO_EXT:reaction_or_response	denotes	response
T699	1205-1211	PR_EXT:000013059	denotes	PGC-1α
T700	1211-1212	SO_EXT:sequence_nullness_or_absence	denotes	−
T701	1213-1214	SO_EXT:sequence_nullness_or_absence	denotes	−
T702	1215-1219	NCBITaxon:10088	denotes	mice
T703	1228-1235	UBERON:0002107	denotes	hepatic
T704	1278-1291	GO:0005739	denotes	mitochondrial
T705	1292-1303	GO:0045333	denotes	respiratory
T706	1330-1340	GO:0010467	denotes	expression
T707	1344-1353	GO:0008610	denotes	lipogenic
T708	1354-1359	SO_EXT:0000704	denotes	genes
T709	1375-1381	PR_EXT:000013059	denotes	PGC-1α
T710	1381-1382	SO_EXT:sequence_nullness_or_absence	denotes	−
T711	1383-1384	SO_EXT:sequence_nullness_or_absence	denotes	−
T712	1385-1389	NCBITaxon:10088	denotes	mice
T713	1428-1435	PR_EXT:000045358	denotes	insulin
T714	1452-1461	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T715	1480-1488	GO:0005773	denotes	vacuolar
T716	1518-1540	UBERON:0001017	denotes	central nervous system
T717	1550-1551	SO_EXT:sequence_nullness_or_absence	denotes	−
T718	1552-1553	SO_EXT:sequence_nullness_or_absence	denotes	−
T719	1554-1558	NCBITaxon:10088	denotes	mice
T720	1591-1597	PR_EXT:000013059	denotes	PGC-1α
T721	1627-1640	_FRAGMENT	denotes	adaptation to
T722	1671-1680	GO:0051866	denotes	stressors
T723	1645-1654	GO:0008152	denotes	metabolic
T724	1659-1670	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T725	1688-1693	GO:0007567	denotes	natal
T726	1694-1698	UBERON:0000104	denotes	life
T3297	1910-1923	GO:0005739	denotes	Mitochondrial
T3298	1959-1968	GO:0065007	denotes	regulated
T3299	2019-2037	NCBITaxon:40674	denotes	mammalian organism
T3300	2048-2053	GO:0007567	denotes	birth
T3301	2059-2064	GO:0007567	denotes	natal
T3302	2065-2078	GO:0005739	denotes	mitochondrial
T3303	2079-2089	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3304	2108-2117	_FRAGMENT	denotes	signaling
T3305	2149-2157	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	pathways
T3306	2122-2137	GO_EXT:transcription	denotes	transcriptional
T3307	2138-2148	GO:0065007	denotes	regulatory
T3308	2163-2170	GO:0065007	denotes	control
T3309	2186-2196	GO:0010467	denotes	expression
T3310	2200-2207	GO:0005634	denotes	nuclear
T3311	2200-2207	_FRAGMENT	denotes	nuclear
T3312	2226-2231	SO_EXT:0000087	denotes	genes
T3313	2212-2225	GO:0005739	denotes	mitochondrial
T3314	2212-2231	SO_EXT:0000088	denotes	mitochondrial genes
T3315	2244-2257	GO:0005739	denotes	mitochondrial
T3316	2269-2279	GO:0008152	denotes	metabolism
T3317	2336-2351	GO_EXT:transcription	denotes	transcriptional
T3318	2336-2363	GO_EXT:0003713	denotes	transcriptional coactivator
T3319	2365-2375	GO:0005777	denotes	peroxisome
T3320	2365-2409	_FRAGMENT	denotes	peroxisome proliferator-activated receptor-γ
T3321	2418-2432	PR_EXT:000013059	denotes	coactivator-1α
T3322	2399-2407	GO_EXT:0004872	denotes	receptor
T3323	2411-2416	_FRAGMENT	denotes	PPARγ
T3324	2434-2440	PR_EXT:000013059	denotes	PGC-1α
T3325	2467-2476	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T3326	2477-2487	GO:0065007	denotes	regulatory
T3327	2514-2529	GO_EXT:transcription	denotes	transcriptional
T3328	2530-2549	_FRAGMENT	denotes	control of cellular
T3329	2557-2567	GO:0031323	denotes	metabolism
T3330	2541-2549	CL_GO_EXT:cell	denotes	cellular
T3331	2579-2592	GO:0005739	denotes	mitochondrial
T3332	2606-2616	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3333	2624-2630	PR_EXT:000013059	denotes	PGC-1α
T3334	2651-2656	NCBITaxon_EXT:yeast	denotes	yeast
T3335	2679-2692	UBERON:0001348	denotes	brown adipose
T3336	2733-2743	GO:0060612	denotes	adipogenic
T3337	2744-2751	GO:0005634	denotes	nuclear
T3338	2752-2760	GO_EXT:0004872	denotes	receptor
T3339	2761-2766	PR_EXT:000013058	denotes	PPARγ
T3340	2839-2864	PR_EXT:000013159	denotes	PGC-1 related coactivator
T3341	2866-2869	PR_EXT:000013159	denotes	PRC
T3342	2879-2885	PR_EXT:000013060	denotes	PGC-1β
T3343	2893-2899	PR_EXT:000013059	denotes	PGC-1α
T3344	2919-2934	GO_EXT:transcription	denotes	transcriptional
T3345	2919-2946	GO_EXT:0003713	denotes	transcriptional coactivator
T3346	2950-2957	GO:0005634	denotes	nuclear
T3347	2965-2972	GO:0005634	denotes	nuclear
T3348	2973-2981	GO_EXT:0004872	denotes	receptor
T3349	2982-2995	GO_EXT:transcription	denotes	transcription
T3350	2982-3003	GO_EXT:transcription_factor	denotes	transcription factors
T3351	3016-3024	CL_GO_EXT:cell	denotes	cellular
T3352	3016-3024	_FRAGMENT	denotes	cellular
T3353	3032-3042	GO:0044237	denotes	metabolism
T3354	3048-3054	PR_EXT:000013059	denotes	PGC-1α
T3355	3113-3119	UBERON:0000479	denotes	tissue
T3356	3129-3139	GO:0010467	denotes	expression
T3357	3175-3186	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T3358	3231-3244	GO:0005739	denotes	mitochondrial
T3359	3245-3248	CHEBI_EXT:ATP	denotes	ATP
T3360	3245-3248	_FRAGMENT	denotes	ATP
T3361	3257-3267	GO:0006754	denotes	production
T3362	3252-3267	GO:0031649	denotes	heat production
T3363	3277-3283	PR_EXT:000013059	denotes	PGC-1α
T3364	3299-3319	UBERON:0001348	denotes	brown adipose tissue
T3365	3321-3324	UBERON:0001348	denotes	BAT
T3366	3327-3332	UBERON:0000948	denotes	heart
T3367	3334-3361	UBERON:0006907	denotes	slow-twitch skeletal muscle
T3368	3367-3373	UBERON:0002113	denotes	kidney
T3369	3378-3385	UBERON:0000479	denotes	tissues
T3370	3405-3418	GO:0005739	denotes	mitochondrial
T3371	3432-3442	GO:0010467	denotes	expression
T3372	3450-3454	SO_EXT:0000704	denotes	gene
T3373	3455-3463	SO_EXT:sequence_coding_function	denotes	encoding
T3374	3464-3470	PR_EXT:000013059	denotes	PGC-1α
T3375	3607-3613	PR_EXT:000013059	denotes	PGC-1α
T3376	3633-3644	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T3377	3645-3655	_FRAGMENT	denotes	control of
T3378	3663-3673	GO:0019222	denotes	metabolism
T3379	3730-3740	GO:0010467	denotes	expression
T3380	3764-3770	PR_EXT:000013059	denotes	PGC-1α
T3381	3796-3809	GO:0005739	denotes	mitochondrial
T3382	3810-3820	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3383	3825-3833	GO:0065007	denotes	regulate
T3384	3834-3847	GO:0005739	denotes	mitochondrial
T3385	3848-3859	GO:0045333	denotes	respiratory
T3386	3877-3883	PR_EXT:000013059	denotes	PGC-1α
T3387	3898-3911	GO_EXT:transcription	denotes	transcription
T3388	3915-3928	GO:0005739	denotes	mitochondrial
T3389	3915-3949	PR_EXT:000017035	denotes	mitochondrial uncoupling protein-1
T3390	3940-3947	CHEBI_PR_EXT:protein	denotes	protein
T3391	3951-3956	PR_EXT:000017035	denotes	UCP-1
T3392	3961-3964	UBERON:0001348	denotes	BAT
T3393	3995-4002	GO:0005634	denotes	nuclear
T3394	4003-4010	CHEBI_GO_EXT:hormone	denotes	hormone
T3395	4011-4020	GO_EXT:0004872	denotes	receptors
T3396	4021-4026	PR_EXT:000013058	denotes	PPARγ
T3397	4031-4038	UBERON:0002046	denotes	thyroid
T3398	4031-4047	GO_EXT:0004887	denotes	thyroid receptor
T3399	4068-4078	GO:0010467	denotes	expression
T3400	4090-4100	GO:0060612	denotes	adipogenic
T3401	4105-4113	GO_EXT:muscle_structure_or_tissue_development	denotes	myogenic
T3402	4114-4123	NCBITaxon:40674	denotes	mammalian
T3403	4124-4128	CL_GO_EXT:cell	denotes	cell
T3404	4153-4159	PR_EXT:000013059	denotes	PGC-1α
T3405	4170-4183	GO:0005739	denotes	mitochondrial
T3406	4184-4194	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3407	4214-4227	GO_EXT:transcription	denotes	transcription
T3408	4214-4234	GO_EXT:transcription_factor	denotes	transcription factor
T3409	4253-4260	GO:0005634	denotes	nuclear
T3410	4253-4282	PR_EXT:000011422	denotes	nuclear respiratory factors 1
T3411	4261-4272	GO:0045333	denotes	respiratory
T3412	4290-4295	PR_EXT:000011422	denotes	NRF-1
T3413	4308-4321	GO:0005739	denotes	mitochondrial
T3414	4308-4344	PR_EXT:000016262	denotes	mitochondrial transcription factor A
T3415	4322-4335	GO_EXT:transcription	denotes	transcription
T3416	4322-4342	GO_EXT:transcription_factor	denotes	transcription factor
T3417	4346-4350	PR_EXT:000016262	denotes	Tfam
T3418	4357-4372	GO_EXT:transcription	denotes	transcriptional
T3419	4373-4383	GO_EXT:regulator	denotes	regulators
T3420	4387-4400	GO:0005739	denotes	mitochondrial
T3421	4387-4404	_FRAGMENT	denotes	mitochondrial DNA
T3422	4423-4434	GO:0006264	denotes	replication
T3423	4401-4404	CHEBI_SO_EXT:DNA	denotes	DNA
T3424	4405-4418	GO_EXT:transcription	denotes	transcription
T3425	4466-4473	UBERON:0000948	denotes	cardiac
T3426	4466-4482	CL:0000746	denotes	cardiac myocytes
T3427	4505-4511	UBERON:0000948	denotes	hearts
T3428	4515-4525	SO_EXT:transgenic_entity	denotes	transgenic
T3429	4526-4530	NCBITaxon:10088	denotes	mice
T3430	4558-4568	GO:0010467	denotes	expression
T3431	4572-4578	PR_EXT:000013059	denotes	PGC-1α
T3432	4588-4601	GO:0005739	denotes	mitochondrial
T3433	4602-4612	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3434	4637-4647	GO:0010467	denotes	expression
T3435	4651-4657	PR_EXT:000013059	denotes	PGC-1α
T3436	4661-4676	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T3437	4680-4690	SO_EXT:transgenic_entity	denotes	transgenic
T3438	4691-4695	NCBITaxon:10088	denotes	mice
T3439	4705-4718	GO:0005739	denotes	mitochondrial
T3440	4741-4753	_FRAGMENT	denotes	formation of
T3441	4807-4820	GO:0048747	denotes	muscle fibers
T3442	4754-4767	GO:0005739	denotes	mitochondrial
T3443	4773-4779	_FRAGMENT	denotes	type I
T3444	4807-4820	CL:0002211	denotes	muscle fibers
T3445	4781-4790	MOP:0000568	denotes	oxidative
T3446	4781-4790	_FRAGMENT	denotes	oxidative
T3447	4807-4820	CL:0002210	denotes	muscle fibers
T3448	4793-4804	_FRAGMENT	denotes	slow-twitch
T3449	4807-4820	CL:0000189	denotes	muscle fibers
T3450	4807-4813	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T3451	4869-4875	PR_EXT:000013059	denotes	PGC-1α
T3452	4899-4912	GO:0005739	denotes	mitochondrial
T3453	4913-4923	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3454	4957-4963	PR_EXT:000013059	denotes	PGC-1α
T3455	4971-4990	GO:0042592	denotes	homeostatic control
T3456	4983-4993	_FRAGMENT	denotes	control of
T3457	5010-5020	GO:0019222	denotes	metabolism
T3458	5022-5028	PR_EXT:000013059	denotes	PGC-1α
T3459	5047-5055	GO:0065007	denotes	regulate
T3460	5068-5075	UBERON:0002107	denotes	hepatic
T3461	5076-5089	GO:0006094	denotes	gluconeogenic
T3462	5090-5095	SO_EXT:0000704	denotes	genes
T3463	5150-5160	GO:0010467	denotes	expression
T3464	5164-5170	PR_EXT:000013059	denotes	PGC-1α
T3465	5186-5199	GO:0005739	denotes	mitochondrial
T3466	5219-5234	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T3467	5238-5244	NCBITaxon:9606	denotes	humans
T3468	5250-5257	PR_EXT:000045358	denotes	insulin
T3469	5307-5338	SO_EXT:0000694	denotes	single nucleotide polymorphisms
T3470	5314-5324	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T3471	5350-5355	NCBITaxon:9606	denotes	human
T3472	5356-5362	PR_EXT:000013059	denotes	PGC-1α
T3473	5363-5367	SO_EXT:0000704	denotes	gene
T3474	5543-5549	PR_EXT:000013059	denotes	PGC-1α
T3475	5564-5574	GO:0065007	denotes	regulating
T3476	5579-5584	GO:0007567	denotes	natal
T3477	5592-5602	GO:0008152	denotes	metabolism
T3478	5630-5636	PR_EXT:000013059	denotes	PGC-1α
T3479	5648-5657	GO:0008152	denotes	metabolic
T3480	5658-5669	GO:0042592	denotes	homeostasis
T3481	5671-5684	GO:0005739	denotes	mitochondrial
T3482	5685-5695	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3483	5714-5720	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3484	5829-5833	NCBITaxon:10088	denotes	mice
T3485	5848-5856	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T3486	5864-5870	PR_EXT:000013059	denotes	PGC-1α
T3487	5871-5875	SO_EXT:0000704	denotes	gene
T3488	5892-5898	PR_EXT:000013059	denotes	PGC-1α
T3489	5898-5899	SO_EXT:sequence_nullness_or_absence	denotes	−
T3490	5900-5901	SO_EXT:sequence_nullness_or_absence	denotes	−
T3491	5902-5906	NCBITaxon:10088	denotes	mice
T3492	5924-5930	PR_EXT:000013059	denotes	PGC-1α
T3493	5965-5970	GO:0007567	denotes	natal
T3494	5991-6004	GO:0005739	denotes	mitochondrial
T3495	6005-6015	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T3496	6069-6075	PR_EXT:000013059	denotes	PGC-1α
T3497	6113-6122	GO:0008152	denotes	metabolic
T3498	6144-6150	UBERON:0000062	denotes	organs
T3499	6171-6203	GO:0051866	denotes	adaptation to physiologic stress
T3500	6215-6220	GO:0007567	denotes	natal
T5568	6255-6261	PR_EXT:000013059	denotes	PGC-1α
T5569	6262-6266	SO_EXT:0000704	denotes	Gene
T5570	6270-6274	NCBITaxon:10088	denotes	Mice
T5571	6292-6296	SO_EXT:0000704	denotes	gene
T5572	6297-6313	SO_EXT:0001644	denotes	targeting vector
T5573	6331-6337	SO_EXT:sequence_deletion_process	denotes	delete
T5574	6338-6343	SO_EXT:0000147	denotes	exons
T5575	6359-6365	NCBITaxon:39107	denotes	murine
T5576	6366-6372	PR_EXT:000013059	denotes	PGC-1α
T5577	6373-6377	SO_EXT:0000704	denotes	gene
T5578	6427-6440	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T5579	6446-6455	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T5580	6480-6489	SO_EXT:engineered_biological_sequence	denotes	construct
T5581	6507-6516	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T5582	6517-6530	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T5583	6576-6579	CHEBI_SO_EXT:DNA	denotes	DNA
T5584	6596-6605	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T5585	6616-6620	SO_EXT:0000147	denotes	exon
T5586	6623-6634	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T5587	6643-6648	SO_EXT:0000147	denotes	exons
T5588	6672-6685	SO_EXT:coding_sequence	denotes	coding region
T5589	6686-6696	GO_SO_EXT:frameshift_entity_or_process	denotes	frameshift
T5590	6737-6747	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5591	6782-6788	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5592	6789-6795	SO_EXT:0001023	denotes	allele
T5593	6878-6884	PR_EXT:000013059	denotes	PGC-1α
T5594	6885-6889	SO_EXT:0000704	denotes	gene
T5595	6925-6935	SO_EXT:0000673	denotes	transcript
T5596	6966-6969	CHEBI_SO_EXT:RNA	denotes	RNA
T5597	6987-6992	UBERON:0000948	denotes	heart
T5598	7003-7010	UBERON:0000479	denotes	tissues
T5599	7014-7020	PR_EXT:000013059	denotes	PGC-1α
T5600	7020-7021	SO_EXT:sequence_nullness_or_absence	denotes	−
T5601	7022-7023	SO_EXT:sequence_nullness_or_absence	denotes	−
T5602	7024-7028	NCBITaxon:10088	denotes	mice
T5603	7076-7078	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T5604	7136-7140	SO_EXT:0000704	denotes	gene
T5605	7175-7182	SO_EXT:0000112	denotes	primers
T5606	7210-7219	_FRAGMENT	denotes	region of
T5607	7236-7246	SO_EXT:0000833	denotes	transcript
T5608	7224-7230	PR_EXT:000013059	denotes	PGC-1α
T5609	7231-7235	SO_EXT:0000704	denotes	gene
T5610	7262-7266	_FRAGMENT	denotes	exon
T5611	7271-7277	SO_EXT:0000333	denotes	border
T5612	7305-7311	PR_EXT:000013059	denotes	PGC-1α
T5613	7311-7312	SO_EXT:sequence_nullness_or_absence	denotes	−
T5614	7313-7314	SO_EXT:sequence_nullness_or_absence	denotes	−
T5615	7315-7319	NCBITaxon:10088	denotes	mice
T5616	7328-7332	_FRAGMENT	denotes	exon
T5617	7337-7343	SO_EXT:0000333	denotes	border
T5618	7381-7387	PR_EXT:000013059	denotes	PGC-1α
T5619	7387-7388	SO_EXT:sequence_nullness_or_absence	denotes	−
T5620	7389-7390	SO_EXT:sequence_nullness_or_absence	denotes	−
T5621	7391-7395	NCBITaxon:10088	denotes	mice
T5622	7402-7406	SO_EXT:0000147	denotes	exon
T5623	7436-7441	UBERON:0000948	denotes	heart
T5624	7446-7449	UBERON:0001348	denotes	BAT
T5625	7453-7462	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T5626	7464-7466	SO_EXT:wild_type_entity_or_quality	denotes	WT
T5627	7476-7482	PR_EXT:000013059	denotes	PGC-1α
T5628	7482-7483	SO_EXT:sequence_nullness_or_absence	denotes	−
T5629	7484-7485	SO_EXT:sequence_nullness_or_absence	denotes	−
T5630	7486-7490	NCBITaxon:10088	denotes	mice
T5631	7520-7524	SO_EXT:0000147	denotes	exon
T5632	7557-7563	PR_EXT:000013059	denotes	PGC-1α
T5633	7563-7564	SO_EXT:sequence_nullness_or_absence	denotes	−
T5634	7565-7566	SO_EXT:sequence_nullness_or_absence	denotes	−
T5635	7567-7571	NCBITaxon:10088	denotes	mice
T5636	7588-7592	_FRAGMENT	denotes	exon
T5637	7599-7605	SO_EXT:0000333	denotes	border
T5638	7648-7657	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T5639	7675-7677	SO_EXT:wild_type_entity_or_quality	denotes	WT
T5640	7682-7688	PR_EXT:000013059	denotes	PGC-1α
T5641	7688-7689	SO_EXT:sequence_nullness_or_absence	denotes	−
T5642	7690-7691	SO_EXT:sequence_nullness_or_absence	denotes	−
T5643	7692-7696	NCBITaxon:10088	denotes	mice
T5644	7732-7738	PR_EXT:000013059	denotes	PGC-1α
T5645	7738-7739	SO_EXT:sequence_nullness_or_absence	denotes	−
T5646	7740-7741	SO_EXT:sequence_nullness_or_absence	denotes	−
T5647	7742-7746	NCBITaxon:10088	denotes	mice
T5648	7768-7774	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5649	7775-7785	SO_EXT:0000673	denotes	transcript
T5650	7799-7805	PR_EXT:000013059	denotes	PGC-1α
T5651	7806-7813	CHEBI_PR_EXT:protein	denotes	protein
T5652	7840-7844	CL_GO_EXT:cell	denotes	cell
T5654	7868-7875	CHEBI_PR_EXT:protein	denotes	protein
T5655	7918-7921	UBERON:0001348	denotes	BAT
T5656	7925-7931	PR_EXT:000013059	denotes	PGC-1α
T5657	7931-7932	SO_EXT:sequence_nullness_or_absence	denotes	−
T5658	7933-7934	SO_EXT:sequence_nullness_or_absence	denotes	−
T5659	7935-7939	NCBITaxon:10088	denotes	mice
T5660	7969-7977	GO_EXT:reaction_or_response	denotes	response
T5661	8037-8047	GO:0010467	denotes	expression
T5662	8051-8057	PR_EXT:000013059	denotes	PGC-1α
T5663	8061-8064	UBERON:0001348	denotes	BAT
T5664	8074-8080	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5665	8081-8087	PR_EXT:000013059	denotes	PGC-1α
T5666	8088-8096	CHEBI_PR_EXT:protein	denotes	proteins
T5667	8173-8183	GO:0010467	denotes	expression
T5668	8191-8196	SO_EXT:0000704	denotes	genes
T5669	8197-8205	SO_EXT:sequence_coding_function	denotes	encoding
T5670	8244-8250	PR_EXT:000013060	denotes	PGC-1β
T5671	8255-8258	PR_EXT:000013159	denotes	PRC
T5672	8293-8298	UBERON:0000948	denotes	heart
T5673	8302-8308	PR_EXT:000013059	denotes	PGC-1α
T5674	8308-8309	SO_EXT:sequence_nullness_or_absence	denotes	−
T5675	8310-8311	SO_EXT:sequence_nullness_or_absence	denotes	−
T5676	8312-8316	NCBITaxon:10088	denotes	mice
T5677	8392-8396	SO_EXT:0000704	denotes	gene
T5678	8427-8433	PR_EXT:000013059	denotes	PGC-1α
T5679	8434-8438	SO_EXT:sequence_nullness	denotes	null
T5680	8439-8445	SO_EXT:0001023	denotes	allele
T7566	10908-10914	PR_EXT:000013059	denotes	PGC-1α
T7567	10914-10915	SO_EXT:sequence_nullness_or_absence	denotes	−
T7568	10916-10917	SO_EXT:sequence_nullness_or_absence	denotes	−
T7569	10918-10922	NCBITaxon:10088	denotes	Mice
T7570	10969-10975	PR_EXT:000013059	denotes	PGC-1α
T7571	10975-10976	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7572	10977-10978	SO_EXT:sequence_nullness_or_absence	denotes	−
T7573	10980-10984	NCBITaxon:10088	denotes	mice
T7574	10990-10994	GO_EXT:breeding	denotes	bred
T7575	11007-11013	PR_EXT:000013059	denotes	PGC-1α
T7576	11013-11014	SO_EXT:sequence_nullness_or_absence	denotes	−
T7577	11015-11016	SO_EXT:sequence_nullness_or_absence	denotes	−
T7578	11041-11049	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T7579	11156-11162	GO:0016265	denotes	deaths
T7580	11203-11209	PR_EXT:000013059	denotes	PGC-1α
T7581	11209-11210	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7582	11211-11212	SO_EXT:sequence_nullness_or_absence	denotes	−
T7583	11217-11223	PR_EXT:000013059	denotes	PGC-1α
T7584	11223-11224	SO_EXT:sequence_nullness_or_absence	denotes	−
T7585	11225-11226	SO_EXT:sequence_nullness_or_absence	denotes	−
T7586	11260-11264	UBERON_EXT:body	denotes	body
T7587	11293-11298	GO:0007567	denotes	birth
T7588	11337-11341	UBERON_EXT:body	denotes	body
T7589	11351-11355	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7590	11360-11366	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7591	11367-11373	PR_EXT:000013059	denotes	PGC-1α
T7592	11373-11374	SO_EXT:sequence_nullness_or_absence	denotes	−
T7593	11375-11376	SO_EXT:sequence_nullness_or_absence	denotes	−
T7594	11377-11381	NCBITaxon:10088	denotes	mice
T7595	11406-11412	PR_EXT:000013059	denotes	PGC-1α
T7596	11412-11413	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7597	11414-11415	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7598	11469-11475	PR_EXT:000013059	denotes	PGC-1α
T7599	11475-11476	SO_EXT:sequence_nullness_or_absence	denotes	−
T7600	11477-11478	SO_EXT:sequence_nullness_or_absence	denotes	−
T7601	11483-11489	PR_EXT:000013059	denotes	PGC-1α
T7602	11489-11490	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7603	11491-11492	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7604	11562-11566	UBERON_EXT:body	denotes	body
T7605	11616-11620	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7606	11625-11631	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7607	11632-11638	PR_EXT:000013059	denotes	PGC-1α
T7608	11638-11639	SO_EXT:sequence_nullness_or_absence	denotes	−
T7609	11640-11641	SO_EXT:sequence_nullness_or_absence	denotes	−
T7610	11642-11646	NCBITaxon:10088	denotes	mice
T7611	11671-11677	PR_EXT:000013059	denotes	PGC-1α
T7612	11677-11678	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7613	11679-11680	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7614	11751-11757	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7615	11758-11764	PR_EXT:000013059	denotes	PGC-1α
T7616	11764-11765	SO_EXT:sequence_nullness_or_absence	denotes	−
T7617	11766-11767	SO_EXT:sequence_nullness_or_absence	denotes	−
T7618	11768-11772	NCBITaxon:10088	denotes	mice
T7619	11830-11836	PR_EXT:000013059	denotes	PGC-1α
T7620	11836-11837	SO_EXT:sequence_nullness_or_absence	denotes	−
T7621	11838-11839	SO_EXT:sequence_nullness_or_absence	denotes	−
T7622	11840-11844	NCBITaxon:10088	denotes	mice
T7623	11884-11888	CHEBI_EXT:33290	denotes	food
T7624	11884-11895	GO:0007631	denotes	food intake
T7625	11993-11997	UBERON_EXT:body	denotes	body
T7626	11998-12001	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7627	12090-12096	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7628	12097-12103	PR_EXT:000013059	denotes	PGC-1α
T7629	12103-12104	SO_EXT:sequence_nullness_or_absence	denotes	−
T7630	12105-12106	SO_EXT:sequence_nullness_or_absence	denotes	−
T7631	12107-12111	NCBITaxon:10088	denotes	mice
T7632	12136-12142	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7633	12143-12149	PR_EXT:000013059	denotes	PGC-1α
T7634	12149-12150	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7635	12151-12152	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7636	12187-12191	UBERON_EXT:body	denotes	body
T7637	12250-12254	UBERON_EXT:body	denotes	body
T7638	12255-12258	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7639	12326-12335	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T7640	12392-12396	UBERON_EXT:body	denotes	body
T7641	12397-12400	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7642	12404-12408	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7643	12409-12415	PR_EXT:000013059	denotes	PGC-1α
T7644	12415-12416	SO_EXT:sequence_nullness_or_absence	denotes	−
T7645	12417-12418	SO_EXT:sequence_nullness_or_absence	denotes	−
T7646	12419-12423	NCBITaxon:10088	denotes	mice
T7647	12453-12457	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7648	12458-12464	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7649	12465-12469	NCBITaxon:10088	denotes	mice
T7650	12506-12510	UBERON_EXT:body	denotes	body
T7651	12511-12514	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T7652	12520-12524	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7653	12525-12527	SO_EXT:wild_type_entity_or_quality	denotes	WT
T7654	13597-13602	UBERON:0000062	denotes	organ
T7655	13650-13663	GO:0005739	denotes	mitochondrial
T7656	13671-13681	GO:0008152	denotes	metabolism
T7657	13690-13695	GO:0007567	denotes	natal
T7658	13696-13702	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7659	13714-13720	UBERON:0000062	denotes	organs
T7660	13737-13742	UBERON:0000948	denotes	heart
T7661	13774-13790	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscles
T7662	13802-13815	UBERON:0001388	denotes	gastrocnemius
T7663	13820-13826	UBERON:0001389	denotes	soleus
T7664	13845-13854	MOP:0000568	denotes	oxidative
T7665	13855-13872	UBERON:0001385	denotes	tibialis anterior
T7666	13902-13906	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T7667	13911-13917	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T7668	13918-13924	PR_EXT:000013059	denotes	PGC-1α
T7669	13924-13925	SO_EXT:sequence_nullness_or_absence	denotes	−
T7670	13926-13927	SO_EXT:sequence_nullness_or_absence	denotes	−
T7671	13928-13932	NCBITaxon:10088	denotes	mice
T7672	13967-13973	PR_EXT:000013059	denotes	PGC-1α
T7673	13973-13974	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7674	13975-13976	SO_EXT:normal_or_wild_type_or_present	denotes	+
T7675	14069-14074	UBERON:0000955	denotes	brain
T7676	14076-14081	UBERON:0002107	denotes	liver
T7677	14083-14089	UBERON:0002113	denotes	kidney
T7678	14095-14098	UBERON:0001348	denotes	BAT
T7679	14144-14153	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T7680	14204-14211	UBERON:0000479	denotes	tissues
T7681	14222-14235	GO:0005739	denotes	mitochondrial
T7682	14265-14270	UBERON:0000948	denotes	heart
T7683	14275-14302	UBERON:0006907	denotes	slow-twitch skeletal muscle
T7684	14319-14325	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7685	14337-14343	PR_EXT:000013059	denotes	PGC-1α
T7686	14343-14344	SO_EXT:sequence_nullness_or_absence	denotes	−
T7687	14345-14346	SO_EXT:sequence_nullness_or_absence	denotes	−
T7688	14347-14351	NCBITaxon:10088	denotes	mice
T9690	14363-14369	UBERON_EXT:muscle_structure_or_tissue	denotes	Muscle
T9691	14370-14383	GO:0005739	denotes	Mitochondrial
T9692	14397-14403	PR_EXT:000013059	denotes	PGC-1α
T9693	14403-14404	SO_EXT:sequence_nullness_or_absence	denotes	−
T9694	14405-14406	SO_EXT:sequence_nullness_or_absence	denotes	−
T9695	14407-14411	NCBITaxon:10088	denotes	Mice
T9696	14485-14491	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9697	14512-14517	GO:0007567	denotes	natal
T9698	14518-14523	UBERON:0000948	denotes	heart
T9699	14528-14543	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T9700	14551-14557	PR_EXT:000013059	denotes	PGC-1α
T9701	14557-14558	SO_EXT:sequence_nullness_or_absence	denotes	−
T9702	14559-14560	SO_EXT:sequence_nullness_or_absence	denotes	−
T9703	14561-14565	NCBITaxon:10088	denotes	mice
T9704	14619-14623	CL_GO_EXT:cell	denotes	cell
T9705	14633-14653	GO:0031012	denotes	extracellular matrix
T9706	14638-14646	CL_GO_EXT:cell	denotes	cellular
T9707	14661-14668	UBERON:0000479	denotes	tissues
T9708	14683-14689	PR_EXT:000013059	denotes	PGC-1α
T9709	14689-14690	SO_EXT:sequence_nullness_or_absence	denotes	−
T9710	14691-14692	SO_EXT:sequence_nullness_or_absence	denotes	−
T9711	14693-14697	NCBITaxon:10088	denotes	mice
T9712	14746-14752	PR_EXT:000013059	denotes	PGC-1α
T9713	14756-14769	GO:0005739	denotes	mitochondrial
T9714	14783-14793	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T9715	14807-14820	GO:0005739	denotes	mitochondrial
T9716	14852-14859	UBERON:0000479	denotes	tissues
T9717	14861-14869	CHEBI:10545	denotes	Electron
T9718	14918-14930	GO:0005739	denotes	mitochondria
T9719	14934-14947	UBERON:0001389	denotes	soleus muscle
T9720	14951-14957	PR_EXT:000013059	denotes	PGC-1α
T9721	14957-14958	SO_EXT:sequence_nullness_or_absence	denotes	−
T9722	14959-14960	SO_EXT:sequence_nullness_or_absence	denotes	−
T9723	14961-14965	NCBITaxon:10088	denotes	mice
T9724	15000-15006	PR_EXT:000013059	denotes	PGC-1α
T9725	15006-15007	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9726	15008-15009	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9727	15064-15072	CHEBI:10545	denotes	electron
T9728	15104-15112	CL_GO_EXT:cell	denotes	cellular
T9729	15131-15137	UBERON:0001389	denotes	soleus
T9730	15138-15150	GO:0005739	denotes	mitochondria
T9731	15178-15184	PR_EXT:000013059	denotes	PGC-1α
T9732	15184-15185	SO_EXT:sequence_nullness_or_absence	denotes	−
T9733	15186-15187	SO_EXT:sequence_nullness_or_absence	denotes	−
T9734	15188-15192	NCBITaxon:10088	denotes	mice
T9735	15205-15211	PR_EXT:000013059	denotes	PGC-1α
T9736	15211-15212	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9737	15213-15214	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9738	15254-15266	GO:0030016	denotes	myofibrillar
T9739	15318-15331	GO:0005739	denotes	mitochondrial
T9740	15332-15342	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T9741	15372-15382	GO:0010467	denotes	expression
T9742	15386-15393	GO:0005634	denotes	nuclear
T9743	15386-15399	SO_EXT:0000087	denotes	nuclear genes
T9744	15400-15408	SO_EXT:sequence_coding_function	denotes	encoding
T9745	15409-15417	CHEBI_PR_EXT:protein	denotes	proteins
T9746	15430-15443	GO:0005739	denotes	mitochondrial
T9747	15444-15452	CHEBI:10545	denotes	electron
T9748	15444-15462	MOP:0000615	denotes	electron transport
T9749	15453-15462	GO_EXT:biological_routing_or_transport	denotes	transport
T9750	15464-15476	PR_EXT:000002199	denotes	cytochrome c
T9751	15464-15476	CHEBI:18070	denotes	cytochrome c
T9752	15481-15491	CHEBI:4056	denotes	cytochrome
T9753	15481-15499	GO_EXT:0004129	denotes	cytochrome oxidase
T9754	15508-15517	MOP:0000568	denotes	oxidative
T9755	15508-15533	GO:0006119	denotes	oxidative phosphorylation
T9756	15535-15563	PR_EXT:000004454	denotes	beta subunit of ATP synthase
T9757	15551-15554	CHEBI_EXT:ATP	denotes	ATP
T9758	15568-15581	UBERON:0001389	denotes	soleus muscle
T9759	15585-15591	PR_EXT:000013059	denotes	PGC-1α
T9760	15591-15592	SO_EXT:sequence_nullness_or_absence	denotes	−
T9761	15593-15594	SO_EXT:sequence_nullness_or_absence	denotes	−
T9762	15595-15599	NCBITaxon:10088	denotes	mice
T9763	15614-15620	PR_EXT:000013059	denotes	PGC-1α
T9764	15620-15621	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9765	15622-15623	SO_EXT:normal_or_wild_type_or_present	denotes	+
T9766	15651-15661	GO:0010467	denotes	expression
T9767	15665-15669	PR_EXT:000016262	denotes	Tfam
T9768	15679-15685	PR_EXT:000013059	denotes	PGC-1α
T9769	15705-15718	GO:0005739	denotes	mitochondrial
T9770	15705-15734	GO:0006264	denotes	mitochondrial DNA replication
T9771	15719-15722	CHEBI_SO_EXT:DNA	denotes	DNA
T9772	15735-15748	GO_EXT:transcription	denotes	transcription
T9773	15768-15774	PR_EXT:000013059	denotes	PGC-1α
T9774	15774-15775	SO_EXT:sequence_nullness_or_absence	denotes	−
T9775	15776-15777	SO_EXT:sequence_nullness_or_absence	denotes	−
T9776	15778-15784	UBERON:0001389	denotes	soleus
T9777	15834-15847	GO:0005739	denotes	mitochondrial
T9778	15848-15858	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T9779	15904-15910	UBERON:0001389	denotes	soleus
T9780	15942-15955	GO:0005739	denotes	mitochondrial
T9781	16003-16008	UBERON:0000948	denotes	heart
T9782	16012-16015	UBERON:0001348	denotes	BAT
T9783	16019-16025	PR_EXT:000013059	denotes	PGC-1α
T9784	16025-16026	SO_EXT:sequence_nullness_or_absence	denotes	−
T9785	16027-16028	SO_EXT:sequence_nullness_or_absence	denotes	−
T9786	16029-16033	NCBITaxon:10088	denotes	mice
T9787	17520-17533	GO:0005739	denotes	mitochondrial
T9788	17562-17577	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T9789	17581-17587	PR_EXT:000013059	denotes	PGC-1α
T9790	17587-17588	SO_EXT:sequence_nullness_or_absence	denotes	−
T9791	17589-17590	SO_EXT:sequence_nullness_or_absence	denotes	−
T9792	17591-17595	NCBITaxon:10088	denotes	mice
T9793	17597-17610	GO:0005739	denotes	mitochondrial
T9794	17611-17622	GO:0045333	denotes	respiration
T9795	17649-17655	UBERON:0000479	denotes	tissue
T9796	17677-17690	UBERON:0001389	denotes	soleus muscle
T9797	17695-17701	UBERON:0001389	denotes	soleus
T9798	17705-17711	PR_EXT:000013059	denotes	PGC-1α
T9799	17711-17712	SO_EXT:sequence_nullness_or_absence	denotes	−
T9800	17713-17714	SO_EXT:sequence_nullness_or_absence	denotes	−
T9801	17715-17719	NCBITaxon:10088	denotes	mice
T9802	17754-17757	CHEBI_EXT:ADP	denotes	ADP
T9803	17770-17781	GO:0045333	denotes	respiration
T9804	17827-17836	CHEBI_EXT:succinate	denotes	succinate
T9805	17875-17886	GO:0045333	denotes	respiration
T9806	17913-17923	CHEBI:25675	denotes	oligomycin
T9807	17955-17964	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T9808	17998-18009	GO:0045333	denotes	respiration
T9809	18013-18016	CHEBI_EXT:ATP	denotes	ATP
T9810	18013-18027	GO:0006754	denotes	ATP production
T9811	18061-18067	PR_EXT:000013059	denotes	PGC-1α
T9812	18067-18068	SO_EXT:sequence_nullness_or_absence	denotes	−
T9813	18069-18070	SO_EXT:sequence_nullness_or_absence	denotes	−
T9814	18071-18075	NCBITaxon:10088	denotes	mice
T9815	18151-18164	GO:0005739	denotes	mitochondrial
T12362	18190-18205	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	Skeletal Muscle
T12363	18218-18224	PR_EXT:000013059	denotes	PGC-1α
T12364	18224-18225	SO_EXT:sequence_nullness_or_absence	denotes	−
T12365	18226-18227	SO_EXT:sequence_nullness_or_absence	denotes	−
T12366	18228-18232	NCBITaxon:10088	denotes	Mice
T12367	18252-18265	GO:0005739	denotes	mitochondrial
T12368	18277-18288	GO:0045333	denotes	respiratory
T12369	18301-18316	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T12370	18348-18363	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T12371	18407-18416	GO:0040011	denotes	locomotor
T12372	18493-18499	PR_EXT:000013059	denotes	PGC-1α
T12373	18499-18500	SO_EXT:sequence_nullness_or_absence	denotes	−
T12374	18501-18502	SO_EXT:sequence_nullness_or_absence	denotes	−
T12375	18503-18507	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T12376	18508-18512	NCBITaxon:10088	denotes	mice
T12377	18560-18571	GO:0040011	denotes	ambulations
T12378	18617-18623	PR_EXT:000013059	denotes	PGC-1α
T12379	18623-18624	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12380	18625-18626	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12381	18696-18704	GO_PATO_EXT:biological_behavior	denotes	behavior
T12382	18721-18727	PR_EXT:000013059	denotes	PGC-1α
T12383	18727-18728	SO_EXT:sequence_nullness_or_absence	denotes	−
T12384	18729-18730	SO_EXT:sequence_nullness_or_absence	denotes	−
T12385	18731-18735	NCBITaxon:10088	denotes	mice
T12386	18824-18830	PR_EXT:000013059	denotes	PGC-1α
T12387	18830-18831	SO_EXT:sequence_nullness_or_absence	denotes	−
T12388	18832-18833	SO_EXT:sequence_nullness_or_absence	denotes	−
T12389	18834-18838	NCBITaxon:10088	denotes	mice
T12390	19233-19239	PR_EXT:000013059	denotes	PGC-1α
T12391	19239-19240	SO_EXT:sequence_nullness_or_absence	denotes	−
T12392	19241-19242	SO_EXT:sequence_nullness_or_absence	denotes	−
T12393	19243-19247	NCBITaxon:10088	denotes	mice
T12394	19323-19334	GO:0001966	denotes	thigmotaxis
T12395	20898-20910	UBERON:0025534	denotes	sensorimotor
T12396	20928-20934	PR_EXT:000013059	denotes	PGC-1α
T12397	20934-20935	SO_EXT:sequence_nullness_or_absence	denotes	−
T12398	20936-20937	SO_EXT:sequence_nullness_or_absence	denotes	−
T12399	20938-20942	NCBITaxon:10088	denotes	mice
T12400	20978-20984	PR_EXT:000013059	denotes	PGC-1α
T12401	20984-20985	SO_EXT:sequence_nullness_or_absence	denotes	−
T12402	20986-20987	SO_EXT:sequence_nullness_or_absence	denotes	−
T12403	20988-20992	NCBITaxon:10088	denotes	mice
T12404	20997-21003	PR_EXT:000013059	denotes	PGC-1α
T12405	21003-21004	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12406	21005-21006	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12407	21142-21154	UBERON:0025534	denotes	sensorimotor
T12408	21184-21190	PR_EXT:000013059	denotes	PGC-1α
T12409	21190-21191	SO_EXT:sequence_nullness_or_absence	denotes	−
T12410	21192-21193	SO_EXT:sequence_nullness_or_absence	denotes	−
T12411	21194-21198	NCBITaxon:10088	denotes	mice
T12412	21213-21219	PR_EXT:000013059	denotes	PGC-1α
T12413	21219-21220	SO_EXT:sequence_nullness_or_absence	denotes	−
T12414	21221-21222	SO_EXT:sequence_nullness_or_absence	denotes	−
T12415	21223-21227	NCBITaxon:10088	denotes	mice
T12416	21291-21297	PR_EXT:000013059	denotes	PGC-1α
T12417	21297-21298	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12418	21299-21300	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12419	21621-21636	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T12420	21686-21692	PR_EXT:000013059	denotes	PGC-1α
T12421	21692-21693	SO_EXT:sequence_nullness_or_absence	denotes	−
T12422	21694-21695	SO_EXT:sequence_nullness_or_absence	denotes	−
T12423	21696-21700	NCBITaxon:10088	denotes	mice
T12424	21719-21725	PR_EXT:000013059	denotes	PGC-1α
T12425	21725-21726	SO_EXT:sequence_nullness_or_absence	denotes	−
T12426	21727-21728	SO_EXT:sequence_nullness_or_absence	denotes	−
T12427	21729-21733	NCBITaxon:10088	denotes	mice
T12428	21818-21824	PR_EXT:000013059	denotes	PGC-1α
T12429	21824-21825	SO_EXT:sequence_nullness_or_absence	denotes	−
T12430	21826-21827	SO_EXT:sequence_nullness_or_absence	denotes	−
T12431	21828-21832	NCBITaxon:10088	denotes	mice
T12432	21916-21922	PR_EXT:000013059	denotes	PGC-1α
T12433	21922-21923	SO_EXT:sequence_nullness_or_absence	denotes	−
T12434	21924-21925	SO_EXT:sequence_nullness_or_absence	denotes	−
T12435	21926-21930	NCBITaxon:10088	denotes	mice
T12436	21954-21960	PR_EXT:000013059	denotes	PGC-1α
T12437	21960-21961	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12438	21962-21963	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12439	21964-21968	NCBITaxon:10088	denotes	mice
T12440	22037-22043	PR_EXT:000013059	denotes	PGC-1α
T12441	22043-22044	SO_EXT:sequence_nullness_or_absence	denotes	−
T12442	22045-22046	SO_EXT:sequence_nullness_or_absence	denotes	−
T12443	22047-22051	NCBITaxon:10088	denotes	mice
T12444	22151-22157	CHEBI_EXT:oxygen	denotes	oxygen
T12445	22198-22204	CHEBI_EXT:oxygen	denotes	oxygen
T12446	22221-22225	UBERON_EXT:body	denotes	body
T12447	22361-22367	PR_EXT:000013059	denotes	PGC-1α
T12448	22367-22368	SO_EXT:sequence_nullness_or_absence	denotes	−
T12449	22369-22370	SO_EXT:sequence_nullness_or_absence	denotes	−
T12450	22371-22375	NCBITaxon:10088	denotes	mice
T12451	22392-22394	CHEBI:15379	denotes	O2
T12452	22423-22429	PR_EXT:000013059	denotes	PGC-1α
T12453	22429-22430	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12454	22431-22432	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12455	22458-22460	CHEBI:15379	denotes	O2
T12456	22511-22517	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T12457	22542-22550	GO_EXT:reaction_or_response	denotes	response
T12458	22589-22602	UBERON:0001389	denotes	soleus muscle
T12459	22697-22710	GO:0005739	denotes	mitochondrial
T12460	22711-22714	CHEBI_EXT:ATP	denotes	ATP
T12461	22711-22725	GO:0006754	denotes	ATP production
T12462	22826-22833	UBERON_EXT:muscle_structure_or_tissue	denotes	muscles
T12463	22848-22854	PR_EXT:000013059	denotes	PGC-1α
T12464	22854-22855	SO_EXT:sequence_nullness_or_absence	denotes	−
T12465	22856-22857	SO_EXT:sequence_nullness_or_absence	denotes	−
T12466	22858-22862	NCBITaxon:10088	denotes	mice
T12467	22867-22873	PR_EXT:000013059	denotes	PGC-1α
T12468	22873-22874	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12469	22875-22876	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12470	23010-23022	GO:0006936	denotes	contractions
T12471	23055-23061	PR_EXT:000013059	denotes	PGC-1α
T12472	23061-23062	SO_EXT:sequence_nullness_or_absence	denotes	−
T12473	23063-23064	SO_EXT:sequence_nullness_or_absence	denotes	−
T12474	23065-23069	NCBITaxon:10088	denotes	mice
T12475	23096-23102	PR_EXT:000013059	denotes	PGC-1α
T12476	23102-23103	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12477	23104-23105	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12478	23201-23216	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T12479	23217-23230	GO:0005739	denotes	mitochondrial
T12480	23269-23275	PR_EXT:000013059	denotes	PGC-1α
T12481	23304-23333	GO:0043501	denotes	adaptation of skeletal muscle
T12482	23318-23333	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T12483	23337-23348	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T15044	23387-23393	UBERON:0000948	denotes	Hearts
T15045	23397-23403	PR_EXT:000013059	denotes	PGC-1α
T15046	23403-23404	SO_EXT:sequence_nullness_or_absence	denotes	−
T15047	23405-23406	SO_EXT:sequence_nullness_or_absence	denotes	−
T15048	23407-23411	NCBITaxon:10088	denotes	Mice
T15049	23412-23418	PR_EXT:000013059	denotes	PGC-1α
T15050	23419-23429	GO:0010467	denotes	expression
T15051	23445-23450	UBERON:0000948	denotes	heart
T15052	23454-23460	UBERON:0000479	denotes	tissue
T15053	23484-23497	GO:0005739	denotes	mitochondrial
T15054	23505-23515	GO:0008152	denotes	metabolism
T15055	23561-23566	GO:0007567	denotes	natal
T15056	23567-23571	UBERON:0000104	denotes	life
T15057	23579-23597	NCBITaxon:40674	denotes	mammalian organism
T15058	23638-23644	PR_EXT:000013059	denotes	PGC-1α
T15059	23644-23645	SO_EXT:sequence_nullness_or_absence	denotes	−
T15060	23646-23647	SO_EXT:sequence_nullness_or_absence	denotes	−
T15061	23648-23652	NCBITaxon:10088	denotes	mice
T15062	23714-23721	UBERON:0004151	denotes	chamber
T15063	23731-23742	UBERON:0002082	denotes	ventricular
T15064	23764-23766	SO_EXT:wild_type_entity_or_quality	denotes	WT
T15065	23796-23803	UBERON:0000948	denotes	Cardiac
T15066	23819-23828	GO:0008152	denotes	metabolic
T15067	23942-23948	PR_EXT:000013059	denotes	PGC-1α
T15068	23948-23949	SO_EXT:sequence_nullness_or_absence	denotes	−
T15069	23950-23951	SO_EXT:sequence_nullness_or_absence	denotes	−
T15070	23952-23956	NCBITaxon:10088	denotes	mice
T15071	24223-24229	PR_EXT:000013059	denotes	PGC-1α
T15072	24229-24230	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15073	24231-24232	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15074	24241-24248	NCBITaxon:33208	denotes	animals
T15075	24326-24332	PR_EXT:000013059	denotes	PGC-1α
T15076	24332-24333	SO_EXT:sequence_nullness_or_absence	denotes	−
T15077	24334-24335	SO_EXT:sequence_nullness_or_absence	denotes	−
T15078	24336-24340	NCBITaxon:10088	denotes	mice
T15079	24442-24448	PR_EXT:000013059	denotes	PGC-1α
T15080	24448-24449	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15081	24450-24451	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15082	24495-24501	PR_EXT:000013059	denotes	PGC-1α
T15083	24501-24502	SO_EXT:sequence_nullness_or_absence	denotes	−
T15084	24503-24504	SO_EXT:sequence_nullness_or_absence	denotes	−
T15085	24505-24509	NCBITaxon:10088	denotes	mice
T15086	24573-24589	UBERON:0002084	denotes	left ventricular
T15087	24616-24621	UBERON:0000948	denotes	heart
T15088	24700-24705	UBERON:0000948	denotes	heart
T15089	24718-24724	PR_EXT:000013059	denotes	PGC-1α
T15090	24724-24725	SO_EXT:sequence_nullness_or_absence	denotes	−
T15091	24726-24727	SO_EXT:sequence_nullness_or_absence	denotes	−
T15092	24728-24732	NCBITaxon:10088	denotes	mice
T15093	24859-24875	UBERON:0002084	denotes	left ventricular
T15094	24919-24925	PR_EXT:000013059	denotes	PGC-1α
T15095	24925-24926	SO_EXT:sequence_nullness_or_absence	denotes	−
T15096	24927-24928	SO_EXT:sequence_nullness_or_absence	denotes	−
T15097	24929-24933	NCBITaxon:10088	denotes	mice
T15098	24947-24953	PR_EXT:000013059	denotes	PGC-1α
T15099	24953-24954	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15100	24955-24956	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15101	24957-24961	NCBITaxon:10088	denotes	mice
T15102	26219-26226	UBERON:0000948	denotes	cardiac
T15103	26330-26345	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T15104	26378-26385	UBERON:0000948	denotes	cardiac
T15105	26400-26406	UBERON:0000948	denotes	hearts
T15106	26410-26416	PR_EXT:000013059	denotes	PGC-1α
T15107	26416-26417	SO_EXT:sequence_nullness_or_absence	denotes	−
T15108	26418-26419	SO_EXT:sequence_nullness_or_absence	denotes	−
T15109	26424-26430	PR_EXT:000013059	denotes	PGC-1α
T15110	26430-26431	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15111	26432-26433	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15112	26434-26438	NCBITaxon:10088	denotes	mice
T15113	26487-26493	UBERON:0000948	denotes	Hearts
T15114	26508-26514	PR_EXT:000013059	denotes	PGC-1α
T15115	26514-26515	SO_EXT:sequence_nullness_or_absence	denotes	−
T15116	26516-26517	SO_EXT:sequence_nullness_or_absence	denotes	−
T15117	26518-26522	NCBITaxon:10088	denotes	mice
T15118	26539-26546	UBERON:0000948	denotes	cardiac
T15119	26553-26560	UBERON:0000948	denotes	cardiac
T15120	26618-26624	PR_EXT:000013059	denotes	PGC-1α
T15121	26624-26625	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15122	26626-26627	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15123	26628-26632	NCBITaxon:10088	denotes	mice
T15124	26694-26701	UBERON:0000948	denotes	cardiac
T15125	26728-26735	UBERON:0000948	denotes	cardiac
T15126	26783-26788	UBERON:0000948	denotes	heart
T15127	26826-26833	UBERON:0000948	denotes	cardiac
T15128	26848-26854	PR_EXT:000013059	denotes	PGC-1α
T15129	26854-26855	SO_EXT:sequence_nullness_or_absence	denotes	−
T15130	26856-26857	SO_EXT:sequence_nullness_or_absence	denotes	−
T15131	26858-26862	NCBITaxon:10088	denotes	mice
T15132	27011-27016	UBERON:0000948	denotes	heart
T15133	27026-27037	UBERON:0002082	denotes	ventricular
T15134	27068-27076	GO_EXT:reaction_or_response	denotes	response
T15135	27084-27086	_FRAGMENT	denotes	β1
T15136	27089-27100	GO_PR_EXT:beta1_adrenergic_receptor	denotes	-adrenergic
T15137	27087-27100	GO_PR_EXT:alpha1_adrenergic_receptor	denotes	α1-adrenergic
T15138	27111-27118	CHEBI_GO_EXT:agonist	denotes	agonist
T15139	27119-27129	CHEBI:4670	denotes	dobutamine
T15140	27186-27197	UBERON:0002082	denotes	ventricular
T15141	27209-27217	GO_EXT:reaction_or_response	denotes	response
T15142	27221-27231	CHEBI:4670	denotes	dobutamine
T15143	27247-27253	PR_EXT:000013059	denotes	PGC-1α
T15144	27253-27254	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15145	27255-27256	SO_EXT:normal_or_wild_type_or_present	denotes	+
T15146	27261-27267	PR_EXT:000013059	denotes	PGC-1α
T15147	27267-27268	SO_EXT:sequence_nullness_or_absence	denotes	−
T15148	27269-27270	SO_EXT:sequence_nullness_or_absence	denotes	−
T15149	27271-27275	NCBITaxon:10088	denotes	mice
T15150	27311-27317	PR_EXT:000013059	denotes	PGC-1α
T15151	27317-27318	SO_EXT:sequence_nullness_or_absence	denotes	−
T15152	27319-27320	SO_EXT:sequence_nullness_or_absence	denotes	−
T15153	27321-27325	NCBITaxon:10088	denotes	mice
T15154	27360-27365	UBERON:0000948	denotes	heart
T15155	27371-27379	GO_EXT:reaction_or_response	denotes	response
T15156	27383-27395	GO_PR_EXT:beta_adrenergic_receptor	denotes	β-adrenergic
T15157	27502-27508	PR_EXT:000013059	denotes	PGC-1α
T15158	27508-27509	SO_EXT:sequence_nullness_or_absence	denotes	−
T15159	27510-27511	SO_EXT:sequence_nullness_or_absence	denotes	−
T15160	27512-27518	UBERON:0000948	denotes	hearts
T15161	27554-27566	GO:0002027	denotes	chronotropic
T15162	27567-27575	GO_EXT:reaction_or_response	denotes	response
T15163	27598-27609	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T15164	27632-27644	GO_PR_EXT:beta_adrenergic_receptor	denotes	β-adrenergic
T15165	27658-27663	UBERON:0000948	denotes	heart
T15166	27714-27725	GO:0006936	denotes	contractile
T17242	27879-27885	PR_EXT:000013059	denotes	PGC-1α
T17243	27885-27886	SO_EXT:sequence_nullness_or_absence	denotes	−
T17244	27887-27888	SO_EXT:sequence_nullness_or_absence	denotes	−
T17245	27889-27893	NCBITaxon:10088	denotes	Mice
T17246	27914-27925	GO:0031649	denotes	Thermogenic
T17247	27926-27934	GO_EXT:reaction_or_response	denotes	Response
T17248	27935-27941	PR_EXT:000013059	denotes	PGC-1α
T17249	27978-27987	GO_EXT:regulator	denotes	regulator
T17250	27991-28004	GO:0005739	denotes	mitochondrial
T17251	28005-28016	GO:0045333	denotes	respiratory
T17252	28052-28067	GO:0031649	denotes	heat production
T17253	28071-28074	UBERON:0001348	denotes	BAT
T17254	28101-28107	PR_EXT:000013059	denotes	PGC-1α
T17255	28140-28151	GO:0031649	denotes	thermogenic
T17256	28152-28160	GO_EXT:reaction_or_response	denotes	response
T17257	28162-28168	PR_EXT:000013059	denotes	PGC-1α
T17258	28168-28169	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17259	28170-28171	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17260	28176-28182	PR_EXT:000013059	denotes	PGC-1α
T17261	28182-28183	SO_EXT:sequence_nullness_or_absence	denotes	−
T17262	28184-28185	SO_EXT:sequence_nullness_or_absence	denotes	−
T17263	28186-28190	NCBITaxon:10088	denotes	mice
T17264	28258-28262	UBERON_EXT:body	denotes	body
T17265	28290-28296	PR_EXT:000013059	denotes	PGC-1α
T17266	28296-28297	SO_EXT:sequence_nullness_or_absence	denotes	−
T17267	28298-28299	SO_EXT:sequence_nullness_or_absence	denotes	−
T17268	28300-28304	NCBITaxon:10088	denotes	mice
T17269	28376-28378	SO_EXT:wild_type_entity_or_quality	denotes	WT
T17270	28500-28506	PR_EXT:000013059	denotes	PGC-1α
T17271	28506-28507	SO_EXT:sequence_nullness_or_absence	denotes	−
T17272	28508-28509	SO_EXT:sequence_nullness_or_absence	denotes	−
T17273	28510-28514	NCBITaxon:10088	denotes	mice
T17274	28563-28569	PR_EXT:000013059	denotes	PGC-1α
T17275	28569-28570	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17276	28571-28572	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17277	28597-28608	GO:0031649	denotes	thermogenic
T17278	28647-28651	NCBITaxon:10088	denotes	mice
T17279	28652-28656	GO_PATO_EXT:aging_or_agedness	denotes	aged
T17280	28689-28693	NCBITaxon:10088	denotes	mice
T17281	29874-29879	CHEBI:18059	denotes	lipid
T17282	29890-29893	UBERON:0001348	denotes	BAT
T17283	29947-29958	GO:0031649	denotes	thermogenic
T17284	29982-29988	PR_EXT:000013059	denotes	PGC-1α
T17285	29988-29989	SO_EXT:sequence_nullness_or_absence	denotes	−
T17286	29990-29991	SO_EXT:sequence_nullness_or_absence	denotes	−
T17287	29992-29996	NCBITaxon:10088	denotes	mice
T17288	30013-30018	CHEBI:18059	denotes	lipid
T17289	30058-30066	CHEBI:10545	denotes	Electron
T17290	30107-30120	GO:0005739	denotes	mitochondrial
T17291	30151-30154	UBERON:0001348	denotes	BAT
T17292	30169-30175	PR_EXT:000013059	denotes	PGC-1α
T17293	30175-30176	SO_EXT:sequence_nullness_or_absence	denotes	−
T17294	30177-30178	SO_EXT:sequence_nullness_or_absence	denotes	−
T17295	30183-30189	PR_EXT:000013059	denotes	PGC-1α
T17296	30189-30190	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17297	30191-30192	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17298	30193-30197	NCBITaxon:10088	denotes	mice
T17299	30272-30275	UBERON:0001348	denotes	BAT
T17300	30276-30288	CHEBI:17855	denotes	triglyceride
T17301	30318-30327	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T17302	30348-30353	PR_EXT:000017035	denotes	UCP-1
T17303	30374-30381	CHEBI_PR_EXT:protein	denotes	protein
T17304	30394-30407	GO:0005739	denotes	mitochondrial
T17305	30408-30419	GO:0045333	denotes	respiratory
T17306	30451-30454	UBERON:0001348	denotes	BAT
T17307	30456-30461	PR_EXT:000017035	denotes	UCP-1
T17308	30462-30466	SO_EXT:0000704	denotes	gene
T17309	30467-30480	GO_EXT:transcription	denotes	transcription
T17310	30509-30515	PR_EXT:000013059	denotes	PGC-1α
T17311	30558-30561	UBERON:0001348	denotes	BAT
T17312	30562-30567	PR_EXT:000017035	denotes	UCP-1
T17313	30568-30572	CHEBI_SO_EXT:mRNA	denotes	mRNA
T17314	30596-30602	PR_EXT:000013059	denotes	PGC-1α
T17315	30602-30603	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17316	30604-30605	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17317	30610-30616	PR_EXT:000013059	denotes	PGC-1α
T17318	30616-30617	SO_EXT:sequence_nullness_or_absence	denotes	−
T17319	30618-30619	SO_EXT:sequence_nullness_or_absence	denotes	−
T17320	30620-30624	NCBITaxon:10088	denotes	mice
T17321	30665-30671	PR_EXT:000013059	denotes	PGC-1α
T17322	30714-30724	GO:0010467	denotes	expression
T17323	30728-30733	PR_EXT:000017035	denotes	UCP-1
T17324	30807-30820	GO:0005739	denotes	mitochondrial
T17325	30821-30832	GO:0045333	denotes	respiration
T17326	30868-30879	GO:0031649	denotes	thermogenic
T17327	30880-30888	GO_EXT:reaction_or_response	denotes	response
T17328	30896-30902	PR_EXT:000013059	denotes	PGC-1α
T17329	30902-30903	SO_EXT:sequence_nullness_or_absence	denotes	−
T17330	30904-30905	SO_EXT:sequence_nullness_or_absence	denotes	−
T17331	30906-30910	NCBITaxon:10088	denotes	mice
T17332	30912-30925	GO:0031649	denotes	Thermogenesis
T17333	30929-30936	NCBITaxon:9989	denotes	rodents
T17334	30948-30961	GO:0005739	denotes	mitochondrial
T17335	30986-30993	GO:0065007	denotes	control
T17336	30997-31019	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3-adrenergic receptor
T17337	31028-31037	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T17338	31064-31070	CHEBI_EXT:oxygen	denotes	oxygen
T17339	31083-31091	GO_EXT:reaction_or_response	denotes	response
T17340	31095-31108	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3-adrenergic
T17341	31137-31143	PR_EXT:000013059	denotes	PGC-1α
T17342	31143-31144	SO_EXT:sequence_nullness_or_absence	denotes	−
T17343	31145-31146	SO_EXT:sequence_nullness_or_absence	denotes	−
T17344	31147-31151	NCBITaxon:10088	denotes	mice
T17345	31181-31187	CHEBI_EXT:oxygen	denotes	oxygen
T17346	31246-31248	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3
T17347	31249-31256	CHEBI_GO_EXT:agonist	denotes	agonist
T17348	31330-31338	GO_EXT:reaction_or_response	denotes	response
T17349	31354-31360	PR_EXT:000013059	denotes	PGC-1α
T17350	31360-31361	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17351	31362-31363	SO_EXT:normal_or_wild_type_or_present	denotes	+
T17352	31372-31378	PR_EXT:000013059	denotes	PGC-1α
T17353	31378-31379	SO_EXT:sequence_nullness_or_absence	denotes	−
T17354	31380-31381	SO_EXT:sequence_nullness_or_absence	denotes	−
T17355	31382-31386	NCBITaxon:10088	denotes	mice
T17356	31432-31441	GO:0008152	denotes	metabolic
T17357	31442-31450	_FRAGMENT	denotes	response
T17358	31458-31460	_FRAGMENT	denotes	to
T17359	31470-31478	GO_EXT:reaction_or_response	denotes	stimulus
T17360	31454-31457	UBERON:0001348	denotes	BAT
T17361	31499-31512	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3-adrenergic
T17362	31543-31549	PR_EXT:000013059	denotes	PGC-1α
T17363	31550-31554	SO_EXT:sequence_nullness	denotes	null
T17364	31555-31559	NCBITaxon:10088	denotes	mice
T17365	31600-31613	GO:0005739	denotes	mitochondrial
T17366	31614-31625	GO:0045333	denotes	respiratory
T20045	31655-31662	UBERON:0002107	denotes	Hepatic
T20046	31676-31682	PR_EXT:000013059	denotes	PGC-1α
T20047	31682-31683	SO_EXT:sequence_nullness_or_absence	denotes	−
T20048	31684-31685	SO_EXT:sequence_nullness_or_absence	denotes	−
T20049	31686-31690	NCBITaxon:10088	denotes	Mice
T20050	31724-31730	PR_EXT:000013059	denotes	PGC-1α
T20051	31742-31749	UBERON:0002107	denotes	hepatic
T20052	31750-31759	GO:0008152	denotes	metabolic
T20053	31780-31785	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20054	31780-31790	CHEBI:35366	denotes	fatty acid
T20055	31780-31800	GO:0019395	denotes	fatty acid oxidation
T20056	31791-31800	MOP:0000568	denotes	oxidation
T20057	31805-31820	GO:0006094	denotes	gluconeogenesis
T20058	31853-31860	UBERON:0002107	denotes	hepatic
T20059	31962-31967	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20060	31962-31972	CHEBI:35366	denotes	fatty acid
T20061	31962-31982	GO:0019395	denotes	fatty acid oxidation
T20062	31973-31982	MOP:0000568	denotes	oxidation
T20063	31987-32000	GO:0006094	denotes	gluconeogenic
T20064	32010-32015	UBERON:0002107	denotes	liver
T20065	32029-32032	GO:0007631	denotes	fed
T20066	32049-32055	UBERON:0002107	denotes	livers
T20067	32063-32069	PR_EXT:000013059	denotes	PGC-1α
T20068	32069-32070	SO_EXT:sequence_nullness_or_absence	denotes	−
T20069	32071-32072	SO_EXT:sequence_nullness_or_absence	denotes	−
T20070	32073-32077	NCBITaxon:10088	denotes	mice
T20071	32203-32209	PR_EXT:000013059	denotes	PGC-1α
T20072	32209-32210	SO_EXT:sequence_nullness_or_absence	denotes	−
T20073	32211-32212	SO_EXT:sequence_nullness_or_absence	denotes	−
T20074	32213-32217	NCBITaxon:10088	denotes	mice
T20075	32235-32242	UBERON:0002107	denotes	hepatic
T20076	32308-32316	CHEBI:10545	denotes	electron
T20077	32349-32354	UBERON:0002107	denotes	liver
T20078	32355-32367	CHEBI:17855	denotes	triglyceride
T20079	32369-32372	CHEBI:17855	denotes	TAG
T20080	32422-32428	UBERON:0001969	denotes	plasma
T20081	32429-32442	CHEBI:17855	denotes	triglycerides
T20082	32451-32456	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20083	32451-32462	CHEBI:35366	denotes	fatty acids
T20084	32475-32484	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T20085	32488-32491	GO:0007631	denotes	fed
T20086	32599-32606	UBERON:0002107	denotes	hepatic
T20087	32617-32625	GO_EXT:reaction_or_response	denotes	response
T20088	32627-32638	CL:0000182	denotes	hepatocytes
T20089	32658-32664	PR_EXT:000013059	denotes	PGC-1α
T20090	32664-32665	SO_EXT:sequence_nullness_or_absence	denotes	−
T20091	32666-32667	SO_EXT:sequence_nullness_or_absence	denotes	−
T20092	32668-32672	NCBITaxon:10088	denotes	mice
T20093	32677-32679	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20094	32690-32696	CHEBI:30823	denotes	Oleate
T20095	32735-32741	PR_EXT:000013059	denotes	PGC-1α
T20096	32741-32742	SO_EXT:sequence_nullness_or_absence	denotes	−
T20097	32743-32744	SO_EXT:sequence_nullness_or_absence	denotes	−
T20098	32745-32756	CL:0000182	denotes	hepatocytes
T20099	32777-32782	CHEBI:18059	denotes	lipid
T20100	32826-32828	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20101	32829-32834	CL_GO_EXT:cell	denotes	cells
T20102	32848-32850	CHEBI:29238	denotes	3H
T20103	32851-32860	CHEBI:7896	denotes	palmitate
T20104	32861-32870	MOP:0000568	denotes	oxidation
T20105	32905-32911	PR_EXT:000013059	denotes	PGC-1α
T20106	32911-32912	SO_EXT:sequence_nullness_or_absence	denotes	−
T20107	32913-32914	SO_EXT:sequence_nullness_or_absence	denotes	−
T20108	32915-32926	CL:0000182	denotes	hepatocytes
T20109	32939-32945	PR_EXT:000013059	denotes	PGC-1α
T20110	32945-32946	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20111	32947-32948	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20112	32949-32960	CL:0000182	denotes	hepatocytes
T20113	33010-33016	CHEBI:30823	denotes	oleate
T20114	33078-33082	CL_GO_EXT:cell	denotes	cell
T20115	33104-33110	PR_EXT:000013059	denotes	PGC-1α
T20116	33110-33111	SO_EXT:sequence_nullness_or_absence	denotes	−
T20117	33112-33113	SO_EXT:sequence_nullness_or_absence	denotes	−
T20118	33114-33125	CL:0000182	denotes	hepatocytes
T20119	33167-33175	CL_GO_EXT:cell	denotes	cellular
T20120	33176-33181	CHEBI:18059	denotes	lipid
T20121	33218-33235	GO:0006869	denotes	delivery of lipid
T20122	33230-33235	CHEBI:18059	denotes	lipid
T20123	35140-35144	PR_EXT:PPAR	denotes	PPAR
T20124	35154-35163	GO_EXT:regulator	denotes	regulator
T20125	35167-35174	UBERON:0002107	denotes	hepatic
T20126	35175-35188	GO:0005739	denotes	mitochondrial
T20127	35189-35194	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20128	35189-35199	CHEBI:35366	denotes	fatty acid
T20129	35189-35209	GO:0019395	denotes	fatty acid oxidation
T20130	35200-35209	MOP:0000568	denotes	oxidation
T20131	35210-35216	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T20132	35217-35221	SO_EXT:0000704	denotes	gene
T20133	35217-35232	GO:0010467	denotes	gene expression
T20134	35266-35272	PR_EXT:000013059	denotes	PGC-1α
T20135	35352-35358	PR_EXT:000013059	denotes	PGC-1α
T20136	35358-35359	SO_EXT:sequence_nullness_or_absence	denotes	−
T20137	35360-35361	SO_EXT:sequence_nullness_or_absence	denotes	−
T20138	35362-35366	NCBITaxon:10088	denotes	mice
T20139	35386-35396	GO:0010467	denotes	expression
T20140	35400-35404	PR_EXT:PPAR	denotes	PPAR
T20141	35412-35417	SO_EXT:0000704	denotes	genes
T20142	35454-35459	SO_EXT:0000704	denotes	genes
T20143	35464-35468	SO_EXT:0000704	denotes	gene
T20144	35464-35479	GO:0010467	denotes	gene expression
T20145	35536-35543	UBERON:0002107	denotes	hepatic
T20146	35544-35554	GO:0010467	denotes	expression
T20147	35558-35562	PR_EXT:PPAR	denotes	PPAR
T20148	35570-35575	SO_EXT:0000704	denotes	genes
T20149	35588-35596	CL_GO_EXT:cell	denotes	cellular
T20150	35597-35602	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20151	35597-35607	CHEBI:35366	denotes	fatty acid
T20152	35612-35621	MOP:0000568	denotes	oxidation
T20153	35623-35627	PR_EXT:000005836	denotes	MCPT
T20154	35632-35636	GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase	denotes	MCAD
T20155	35683-35692	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T20156	35699-35702	GO:0007631	denotes	fed
T20157	35812-35815	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T20158	35816-35825	MOP:0000568	denotes	oxidation
T20159	35833-35844	CL:0000182	denotes	hepatocytes
T20160	35852-35858	PR_EXT:000013059	denotes	PGC-1α
T20161	35858-35859	SO_EXT:sequence_nullness_or_absence	denotes	−
T20162	35860-35861	SO_EXT:sequence_nullness_or_absence	denotes	−
T20163	35862-35866	NCBITaxon:10088	denotes	mice
T20164	35890-35903	GO:0005739	denotes	mitochondrial
T20165	35904-35915	GO:0045333	denotes	respiratory
T20166	35942-35944	SO_EXT:wild_type_entity_or_quality	denotes	WT
T20167	35955-35961	PR_EXT:000013059	denotes	PGC-1α
T20168	35961-35962	SO_EXT:sequence_nullness_or_absence	denotes	−
T20169	35963-35964	SO_EXT:sequence_nullness_or_absence	denotes	−
T20170	35965-35976	CL:0000182	denotes	hepatocytes
T20171	36050-36061	GO:0045333	denotes	respiration
T20172	36164-36171	UBERON:0002107	denotes	hepatic
T20173	36204-36207	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T20174	36208-36217	MOP:0000568	denotes	oxidation
T20175	36225-36238	GO:0005739	denotes	mitochondrial
T20176	36239-36250	GO:0045333	denotes	respiratory
T20177	36959-36964	UBERON:0002107	denotes	liver
T20178	36965-36969	SO_EXT:0000704	denotes	gene
T20179	36965-36980	GO:0010467	denotes	gene expression
T20180	37035-37040	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T20181	37035-37045	CHEBI:35366	denotes	fatty acid
T20182	37035-37055	GO:0019395	denotes	fatty acid oxidation
T20183	37046-37055	MOP:0000568	denotes	oxidation
T20184	37071-37077	PR_EXT:000013059	denotes	PGC-1α
T20185	37077-37078	SO_EXT:sequence_nullness_or_absence	denotes	−
T20186	37079-37080	SO_EXT:sequence_nullness_or_absence	denotes	−
T20187	37081-37085	NCBITaxon:10088	denotes	mice
T20188	37142-37148	CHEBI:15889	denotes	sterol
T20189	37142-37167	SO_EXT:0001861	denotes	sterol regulatory element
T20190	37142-37183	PR_EXT:000028988	denotes	sterol regulatory element binding protein
T20191	37149-37159	GO:0065007	denotes	regulatory
T20192	37168-37175	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T20193	37176-37183	CHEBI_PR_EXT:protein	denotes	protein
T20194	37188-37193	PR_EXT:000028988	denotes	SREBP
T20195	37253-37268	GO_EXT:negative_regulation	denotes	down-regulation
T20196	37272-37277	PR_EXT:000028988	denotes	SREBP
T20197	37296-37300	SO_EXT:0000704	denotes	gene
T20198	37301-37313	CHEBI:15541	denotes	stearoyl-CoA
T20199	37301-37324	GO_PR_EXT:stearoyl_CoA_desaturase	denotes	stearoyl-CoA desaturase
T20200	37326-37330	PR_EXT:000015921	denotes	SCD1
T20201	37350-37356	PR_EXT:000013059	denotes	PGC-1α
T20202	37356-37357	SO_EXT:sequence_nullness_or_absence	denotes	−
T20203	37358-37359	SO_EXT:sequence_nullness_or_absence	denotes	−
T20204	37360-37364	NCBITaxon:10088	denotes	mice
T20205	37389-37399	GO:0010467	denotes	expression
T20206	37407-37411	SO_EXT:0000704	denotes	gene
T20207	37412-37420	SO_EXT:sequence_coding_function	denotes	encoding
T20208	37421-37432	CHEBI:18035	denotes	diglyceride
T20209	37421-37448	GO_PR_EXT:diacylglycerol_acyltransferase	denotes	diglyceride acyltransferase
T20210	37450-37454	GO_PR_EXT:diacylglycerol_acyltransferase	denotes	DGAT
T20211	37463-37472	GO_MOP_EXT:catalysis	denotes	catalyzes
T20212	37490-37493	CHEBI:17855	denotes	TAG
T20213	37490-37503	GO:0019432	denotes	TAG synthesis
T20214	37576-37582	PR_EXT:000013059	denotes	PGC-1α
T20215	37582-37583	SO_EXT:sequence_nullness_or_absence	denotes	−
T20216	37584-37585	SO_EXT:sequence_nullness_or_absence	denotes	−
T20217	37586-37590	NCBITaxon:10088	denotes	mice
T20218	37657-37666	MOP:0000568	denotes	oxidation
T20219	37686-37689	CHEBI:17855	denotes	TAG
T20220	37686-37699	GO:0019432	denotes	TAG synthesis
T20221	37729-37735	PR_EXT:000013059	denotes	PGC-1α
T20222	37735-37736	SO_EXT:sequence_nullness_or_absence	denotes	−
T20223	37737-37738	SO_EXT:sequence_nullness_or_absence	denotes	−
T20224	37739-37743	NCBITaxon:10088	denotes	mice
T20225	37793-37795	CHEBI:29238	denotes	3H
T20226	37796-37804	CHEBI:17754	denotes	glycerol
T20227	37824-37827	CHEBI:17855	denotes	TAG
T20228	37856-37867	CL:0000182	denotes	hepatocytes
T20229	37869-37871	CHEBI:29238	denotes	3H
T20230	37872-37875	CHEBI:17855	denotes	TAG
T20231	37918-37929	CL:0000182	denotes	hepatocytes
T20232	37944-37950	PR_EXT:000013059	denotes	PGC-1α
T20233	37950-37951	SO_EXT:sequence_nullness_or_absence	denotes	−
T20234	37952-37953	SO_EXT:sequence_nullness_or_absence	denotes	−
T20235	37954-37958	NCBITaxon:10088	denotes	mice
T20236	37971-37977	PR_EXT:000013059	denotes	PGC-1α
T20237	37977-37978	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20238	37979-37980	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20239	38019-38022	CHEBI:17855	denotes	TAG
T20240	38019-38032	GO:0019432	denotes	TAG synthesis
T20241	38056-38062	PR_EXT:000013059	denotes	PGC-1α
T20242	38063-38067	SO_EXT:sequence_nullness	denotes	null
T20243	38068-38079	CL:0000182	denotes	hepatocytes
T20244	38158-38165	UBERON:0002107	denotes	hepatic
T22425	38210-38216	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	Female
T22426	38217-38223	PR_EXT:000013059	denotes	PGC-1α
T22427	38223-38224	SO_EXT:sequence_nullness_or_absence	denotes	−
T22428	38225-38226	SO_EXT:sequence_nullness_or_absence	denotes	−
T22429	38227-38231	NCBITaxon:10088	denotes	Mice
T22430	38247-38254	PR_EXT:000045358	denotes	Insulin
T22431	38310-38316	PR_EXT:000013059	denotes	PGC-1α
T22432	38317-38348	SO_EXT:0000694	denotes	single nucleotide polymorphisms
T22433	38324-38334	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T22434	38353-38363	SO_EXT:0001024	denotes	haplotypes
T22435	38397-38404	PR_EXT:000045358	denotes	insulin
T22436	38478-38485	PR_EXT:000045358	denotes	insulin
T22437	38509-38515	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T22439	38570-38577	PR_EXT:000045358	denotes	insulin
T22440	38610-38616	PR_EXT:000013059	denotes	PGC-1α
T22441	38616-38617	SO_EXT:sequence_nullness_or_absence	denotes	−
T22442	38618-38619	SO_EXT:sequence_nullness_or_absence	denotes	−
T22443	38620-38624	NCBITaxon:10088	denotes	mice
T22444	38626-38633	CHEBI:17234	denotes	Glucose
T22445	38664-38668	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T22446	38673-38679	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T22447	38680-38684	NCBITaxon:10088	denotes	mice
T22448	38723-38728	UBERON:0000178	denotes	blood
T22449	38729-38736	CHEBI:17234	denotes	glucose
T22450	38755-38761	PR_EXT:000013059	denotes	PGC-1α
T22451	38761-38762	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22452	38763-38764	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22453	38769-38775	PR_EXT:000013059	denotes	PGC-1α
T22454	38775-38776	SO_EXT:sequence_nullness_or_absence	denotes	−
T22455	38777-38778	SO_EXT:sequence_nullness_or_absence	denotes	−
T22456	38823-38829	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T22457	38830-38836	PR_EXT:000013059	denotes	PGC-1α
T22458	38836-38837	SO_EXT:sequence_nullness_or_absence	denotes	−
T22459	38838-38839	SO_EXT:sequence_nullness_or_absence	denotes	−
T22460	38840-38844	NCBITaxon:10088	denotes	mice
T22461	38868-38872	UBERON_EXT:body	denotes	body
T22462	38873-38876	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22463	38885-38892	CHEBI:17234	denotes	glucose
T22464	38907-38914	PR_EXT:000045358	denotes	insulin
T22465	38968-38975	CHEBI:17234	denotes	Glucose
T22466	39008-39014	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T22467	39015-39021	PR_EXT:000013059	denotes	PGC-1α
T22468	39021-39022	SO_EXT:sequence_nullness_or_absence	denotes	−
T22469	39023-39024	SO_EXT:sequence_nullness_or_absence	denotes	−
T22470	39025-39029	NCBITaxon:10088	denotes	mice
T22471	39063-39067	UBERON_EXT:body	denotes	body
T22472	39126-39132	PR_EXT:000013059	denotes	PGC-1α
T22473	39132-39133	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22474	39134-39135	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22475	39136-39140	NCBITaxon:10088	denotes	mice
T22476	39158-39164	PR_EXT:000013059	denotes	PGC-1α
T22477	39164-39165	SO_EXT:sequence_nullness_or_absence	denotes	−
T22478	39166-39167	SO_EXT:sequence_nullness_or_absence	denotes	−
T22479	39168-39172	NCBITaxon:10088	denotes	mice
T22480	39191-39197	PR_EXT:000013059	denotes	PGC-1α
T22481	39197-39198	SO_EXT:sequence_nullness_or_absence	denotes	−
T22482	39199-39200	SO_EXT:sequence_nullness_or_absence	denotes	−
T22483	39201-39205	NCBITaxon:10088	denotes	mice
T22484	39234-39241	CHEBI:17234	denotes	glucose
T22485	39264-39266	SO_EXT:wild_type_entity_or_quality	denotes	WT
T22486	39267-39271	NCBITaxon:10088	denotes	mice
T22487	39284-39290	NCBITaxon:9989	denotes	rodent
T22488	39291-39295	CHEBI_EXT:33290	denotes	chow
T22489	39319-39326	CHEBI:17234	denotes	glucose
T22490	39319-39338	GO:0042593	denotes	glucose homeostasis
T22491	39342-39350	GO_EXT:reaction_or_response	denotes	response
T22492	39359-39362	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22493	39369-39375	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T22494	39376-39382	PR_EXT:000013059	denotes	PGC-1α
T22495	39382-39383	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22496	39384-39385	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22497	39390-39396	PR_EXT:000013059	denotes	PGC-1α
T22498	39396-39397	SO_EXT:sequence_nullness_or_absence	denotes	−
T22499	39398-39399	SO_EXT:sequence_nullness_or_absence	denotes	−
T22500	39400-39404	NCBITaxon:10088	denotes	mice
T22501	39425-39428	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22502	39429-39433	CHEBI_EXT:33290	denotes	chow
T22503	39453-39456	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22504	39522-39525	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22505	39551-39557	PR_EXT:000013059	denotes	PGC-1α
T22506	39557-39558	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22507	39559-39560	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22508	39565-39571	PR_EXT:000013059	denotes	PGC-1α
T22509	39571-39572	SO_EXT:sequence_nullness_or_absence	denotes	−
T22510	39573-39574	SO_EXT:sequence_nullness_or_absence	denotes	−
T22511	39613-39619	PR_EXT:000013059	denotes	PGC-1α
T22512	39619-39620	SO_EXT:sequence_nullness_or_absence	denotes	−
T22513	39621-39622	SO_EXT:sequence_nullness_or_absence	denotes	−
T22514	39623-39627	NCBITaxon:10088	denotes	mice
T22515	39638-39641	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22516	39671-39678	CHEBI:17234	denotes	glucose
T22517	39692-39699	PR_EXT:000045358	denotes	insulin
T22518	39726-39732	PR_EXT:000013059	denotes	PGC-1α
T22519	39732-39733	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22520	39734-39735	SO_EXT:normal_or_wild_type_or_present	denotes	+
T22521	39736-39740	NCBITaxon:10088	denotes	mice
T22522	39814-39818	UBERON_EXT:body	denotes	body
T22523	39819-39822	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T22524	39854-39860	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T22525	39861-39867	PR_EXT:000013059	denotes	PGC-1α
T22526	39867-39868	SO_EXT:sequence_nullness_or_absence	denotes	−
T22527	39869-39870	SO_EXT:sequence_nullness_or_absence	denotes	−
T22528	39871-39875	NCBITaxon:10088	denotes	mice
T22529	39891-39898	PR_EXT:000045358	denotes	insulin
T22530	39925-39931	PR_EXT:000013059	denotes	PGC-1α
T22531	39931-39932	SO_EXT:sequence_nullness_or_absence	denotes	−
T22532	39933-39934	SO_EXT:sequence_nullness_or_absence	denotes	−
T22533	39935-39939	NCBITaxon:10088	denotes	mice
T22534	39949-39956	CHEBI:17234	denotes	glucose
T22535	39970-39977	PR_EXT:000045358	denotes	insulin
T22536	39993-39995	SO_EXT:wild_type_entity_or_quality	denotes	WT
T22537	39996-40000	NCBITaxon:10088	denotes	mice
T22538	40011-40014	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T23973	40735-40757	UBERON:0001017	denotes	Central Nervous System
T23974	40761-40767	PR_EXT:000013059	denotes	PGC-1α
T23975	40767-40768	SO_EXT:sequence_nullness_or_absence	denotes	−
T23976	40769-40770	SO_EXT:sequence_nullness_or_absence	denotes	−
T23977	40771-40775	NCBITaxon:10088	denotes	Mice
T23978	40793-40800	UBERON:0000479	denotes	tissues
T23979	40808-40814	PR_EXT:000013059	denotes	PGC-1α
T23980	40814-40815	SO_EXT:sequence_nullness_or_absence	denotes	−
T23981	40816-40817	SO_EXT:sequence_nullness_or_absence	denotes	−
T23982	40818-40822	NCBITaxon:10088	denotes	mice
T23983	40856-40861	UBERON:0000955	denotes	brain
T23984	40910-40916	PR_EXT:000013059	denotes	PGC-1α
T23985	40916-40917	SO_EXT:sequence_nullness_or_absence	denotes	−
T23986	40918-40919	SO_EXT:sequence_nullness_or_absence	denotes	−
T23987	40920-40925	UBERON:0000955	denotes	brain
T23988	40926-40932	UBERON:0000479	denotes	tissue
T23989	40971-40988	UBERON:0000956	denotes	cerebral cortical
T23990	40971-40997	CL:0010012	denotes	cerebral cortical neuronal
T23991	41047-41053	CL:0000540	denotes	neuron
T23992	41081-41094	UBERON:0001872	denotes	parietal lobe
T23993	41096-41102	PR_EXT:000013059	denotes	PGC-1α
T23994	41102-41103	SO_EXT:normal_or_wild_type_or_present	denotes	+
T23995	41104-41105	SO_EXT:normal_or_wild_type_or_present	denotes	+
T23996	41118-41125	CL:0000540	denotes	neurons
T23997	41137-41143	PR_EXT:000013059	denotes	PGC-1α
T23998	41143-41144	SO_EXT:sequence_nullness_or_absence	denotes	−
T23999	41145-41146	SO_EXT:sequence_nullness_or_absence	denotes	−
T24000	41159-41166	CL:0000540	denotes	neurons
T24001	41237-41245	UBERON:0002606	denotes	neuropil
T24002	41261-41278	CL:0000598	denotes	pyramidal neurons
T24003	41305-41320	UBERON:0000956	denotes	cerebral cortex
T24004	41339-41345	PR_EXT:000013059	denotes	PGC-1α
T24005	41345-41346	SO_EXT:sequence_nullness_or_absence	denotes	−
T24006	41347-41348	SO_EXT:sequence_nullness_or_absence	denotes	−
T24007	41349-41353	NCBITaxon:10088	denotes	mice
T24008	41366-41372	PR_EXT:000013059	denotes	PGC-1α
T24009	41372-41373	SO_EXT:normal_or_wild_type_or_present	denotes	+
T24010	41374-41375	SO_EXT:normal_or_wild_type_or_present	denotes	+
T24011	41376-41380	NCBITaxon:10088	denotes	mice
T24012	41420-41430	CL:0000127	denotes	astrocytic
T24013	41431-41437	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T24014	41439-41444	CL:0000125	denotes	glial
T24015	41439-41470	PR_EXT:000007939	denotes	glial fibrillary acidic protein
T24016	41456-41462	CHEBI_EXT:37527	denotes	acidic
T24017	41463-41470	CHEBI_PR_EXT:protein	denotes	protein
T24018	41513-41523	CL:0000127	denotes	astrocytic
T24019	41513-41533	GO:0097449	denotes	astrocytic processes
T24020	41537-41543	PR_EXT:000013059	denotes	PGC-1α
T24021	41543-41544	SO_EXT:sequence_nullness_or_absence	denotes	−
T24022	41545-41546	SO_EXT:sequence_nullness_or_absence	denotes	−
T24023	41547-41552	NCBITaxon:10088	denotes	mouse
T24024	41553-41568	UBERON:0000956	denotes	cerebral cortex
T24025	41593-41604	UBERON_EXT:hippocampus_proper_or_hippocampal_formation	denotes	hippocampus
T24026	41617-41625	CL:0000540	denotes	neuronal
T24027	41679-41694	UBERON:0016530	denotes	parietal cortex
T24028	41720-41728	UBERON:0002606	denotes	neuropil
T24029	41733-41740	CL:0000540	denotes	neurons
T24030	41748-41754	PR_EXT:000013059	denotes	PGC-1α
T24031	41754-41755	SO_EXT:sequence_nullness_or_absence	denotes	−
T24032	41756-41757	SO_EXT:sequence_nullness_or_absence	denotes	−
T24033	41758-41771	UBERON:0002420	denotes	basal ganglia
T24034	41773-41780	UBERON:0001873	denotes	caudate
T24035	41785-41792	UBERON:0001874	denotes	putamen
T24036	41878-41883	CL:0000125	denotes	glial
T24037	41878-41909	PR_EXT:000007939	denotes	glial fibrillary acidic protein
T24038	41895-41901	CHEBI_EXT:37527	denotes	acidic
T24039	41902-41909	CHEBI_PR_EXT:protein	denotes	protein
T24040	41925-41935	CL:0000127	denotes	astrocytic
T24041	41925-41945	GO:0097449	denotes	astrocytic processes
T24042	42015-42024	UBERON:0002298	denotes	brainstem
T24043	42055-42063	_FRAGMENT	denotes	Purkinje
T24044	42076-42088	CL:0000121	denotes	cell neurons
T24045	42068-42088	CL:0000120	denotes	granule cell neurons
T24046	42076-42080	CL_GO_EXT:cell	denotes	cell
T24047	42112-42118	PR_EXT:000013059	denotes	PGC-1α
T24048	42118-42119	SO_EXT:sequence_nullness_or_absence	denotes	−
T24049	42120-42121	SO_EXT:sequence_nullness_or_absence	denotes	−
T24050	42122-42139	UBERON:0002129	denotes	cerebellar cortex
T24051	42149-42159	CL:0000129	denotes	microglial
T24052	42149-42173	GO:0061518	denotes	microglial proliferation
T24053	42178-42190	UBERON:0014930	denotes	perivascular
T24054	42191-42202	CL:0000542	denotes	lymphocytic
T24055	42203-42215	GO_PATO_EXT:inflammatory_process_or_quality	denotes	inflammatory
T24056	42246-42252	PR_EXT:000013059	denotes	PGC-1α
T24057	42252-42253	SO_EXT:sequence_nullness_or_absence	denotes	−
T24058	42254-42255	SO_EXT:sequence_nullness_or_absence	denotes	−
T24059	42256-42259	UBERON:0001017	denotes	CNS
T24060	42878-42884	PR_EXT:000013059	denotes	PGC-1α
T24061	42884-42885	SO_EXT:sequence_nullness_or_absence	denotes	−
T24062	42886-42887	SO_EXT:sequence_nullness_or_absence	denotes	−
T24063	42888-42896	UBERON:0001872	denotes	parietal
T24064	42897-42912	UBERON:0000956	denotes	cerebral cortex
T24065	42955-42962	CL:0000540	denotes	neurons
T24066	42967-42975	UBERON:0002606	denotes	neuropil
T24067	42990-42998	GO:0005773	denotes	Vacuoles
T24068	43024-43034	GO:0016020	denotes	membranous
T24069	43072-43080	UBERON:0001851	denotes	cortical
T24070	43072-43088	CL:0010012	denotes	cortical neurons
T24071	43090-43101	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	Subcellular
T24072	43093-43101	CL_GO_EXT:cell	denotes	cellular
T24073	43102-43114	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T24074	43122-43130	GO:0005773	denotes	vacuoles
T24075	43205-43213	UBERON:0002606	denotes	neuropil
T24076	43227-43237	GO:0006909	denotes	phagocytic
T24077	43227-43243	CL:0000234	denotes	phagocytic cells
T24078	43238-43243	CL_GO_EXT:cell	denotes	cells
T24079	43245-43256	GO:0098793	denotes	presynaptic
T24080	43257-43272	GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus	denotes	nerve terminals
T24081	43263-43272	GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus	denotes	terminals
T24082	43289-43293	GO:0044297	denotes	soma
T24083	43311-43321	GO:0043204	denotes	perikaryal
T29907	43427-43433	PR_EXT:000013059	denotes	PGC-1α
T29908	43473-43486	GO_EXT:transcription	denotes	transcription
T29909	43473-43494	GO_EXT:transcription_factor	denotes	transcription factors
T29910	43514-43533	GO:0008152	denotes	metabolic processes
T29911	43544-43549	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T29912	43544-43554	CHEBI:35366	denotes	fatty acid
T29913	43544-43564	GO:0019395	denotes	fatty acid oxidation
T29914	43555-43564	MOP:0000568	denotes	oxidation
T29915	43566-43574	CHEBI:10545	denotes	electron
T29916	43566-43584	MOP:0000615	denotes	electron transport
T29917	43575-43584	GO_EXT:biological_routing_or_transport	denotes	transport
T29918	43590-43599	MOP:0000568	denotes	oxidative
T29919	43590-43615	GO:0006119	denotes	oxidative phosphorylation
T29920	43628-43638	GO:0010467	denotes	expression
T29921	43642-43648	PR_EXT:000013059	denotes	PGC-1α
T29922	43658-43671	GO:0005739	denotes	mitochondrial
T29923	43672-43682	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T29924	43738-43743	PR_EXT:000011422	denotes	NRF-1
T29925	43760-43766	SO:0000910	denotes	orphan
T29926	43767-43774	GO:0005634	denotes	nuclear
T29927	43775-43783	GO_EXT:0004872	denotes	receptor
T29928	43784-43792	CHEBI_EXT:50114	denotes	estrogen
T29929	43784-43811	PR_EXT:000007208	denotes	estrogen-related receptor α
T29930	43801-43809	GO_EXT:0004872	denotes	receptor
T29931	43883-43889	PR_EXT:000013059	denotes	PGC-1α
T29932	43923-43942	GO:0008152	denotes	metabolic processes
T29933	43953-43966	GO:0005739	denotes	mitochondrial
T29934	43967-43977	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T29935	44007-44011	SO_EXT:0000704	denotes	gene
T29936	44012-44020	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T29937	44024-44028	NCBITaxon:10088	denotes	mice
T29938	44048-44054	PR_EXT:000013059	denotes	PGC-1α
T29939	44083-44094	UBERON:0000922	denotes	embryologic
T29940	44083-44106	GO:0009790	denotes	embryologic development
T29941	44136-44149	GO:0005739	denotes	mitochondrial
T29942	44150-44160	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T29943	44225-44231	PR_EXT:000013059	denotes	PGC-1α
T29944	44267-44275	GO:0065007	denotes	regulate
T29945	44280-44285	GO:0007567	denotes	natal
T29946	44286-44299	GO:0005739	denotes	mitochondrial
T29947	44313-44321	CL_GO_EXT:cell	denotes	cellular
T29948	44313-44321	_FRAGMENT	denotes	cellular
T29949	44329-44339	GO:0044237	denotes	metabolism
T29950	44366-44374	NCBITaxon:1	denotes	organism
T29951	44390-44399	GO:0008152	denotes	metabolic
T29952	44418-44423	GO:0007567	denotes	natal
T29953	44444-44457	GO:0005739	denotes	mitochondrial
T29954	44490-44517	UBERON:0006907	denotes	slow-twitch skeletal muscle
T29955	44521-44527	PR_EXT:000013059	denotes	PGC-1α
T29956	44527-44528	SO_EXT:sequence_nullness_or_absence	denotes	−
T29957	44529-44530	SO_EXT:sequence_nullness_or_absence	denotes	−
T29958	44531-44535	NCBITaxon:10088	denotes	mice
T29959	44545-44558	GO:0005739	denotes	mitochondrial
T29960	44559-44570	GO:0045333	denotes	respiratory
T29961	44621-44636	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T29962	44641-44646	UBERON:0002107	denotes	liver
T29963	44650-44656	PR_EXT:000013059	denotes	PGC-1α
T29964	44656-44657	SO_EXT:sequence_nullness_or_absence	denotes	−
T29965	44658-44659	SO_EXT:sequence_nullness_or_absence	denotes	−
T29966	44660-44664	NCBITaxon:10088	denotes	mice
T29967	44677-44683	GO_EXT:biological_growth_entity_or_process	denotes	growth
T29968	44687-44692	UBERON:0000948	denotes	heart
T29969	44697-44710	UBERON:0001389	denotes	soleus muscle
T29970	44712-44719	UBERON:0000479	denotes	tissues
T29971	44742-44755	GO:0005739	denotes	mitochondrial
T29972	44795-44802	GO:0065007	denotes	control
T29973	44806-44810	UBERON_EXT:body	denotes	body
T29974	44811-44814	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T29975	44839-44845	PR_EXT:000013059	denotes	PGC-1α
T29976	44845-44846	SO_EXT:sequence_nullness_or_absence	denotes	−
T29977	44847-44848	SO_EXT:sequence_nullness_or_absence	denotes	−
T29978	44849-44853	NCBITaxon:10088	denotes	mice
T29979	44864-44870	PR_EXT:000013059	denotes	PGC-1α
T29980	44870-44871	SO_EXT:sequence_nullness_or_absence	denotes	−
T29981	44872-44873	SO_EXT:sequence_nullness_or_absence	denotes	−
T29982	44874-44878	NCBITaxon:10088	denotes	mice
T29983	44886-44893	GO_EXT:reaction_or_response	denotes	respond
T29984	44919-44930	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T29985	44970-44979	MOP:0000568	denotes	oxidative
T29986	45048-45054	PR_EXT:000013059	denotes	PGC-1α
T29987	45095-45108	GO:0005739	denotes	mitochondrial
T29988	45109-45119	GO_PATO_EXT:biological_maturation	denotes	maturation
T29989	45168-45173	GO:0007567	denotes	natal
T29990	45235-45239	NCBITaxon:10088	denotes	mice
T29991	45248-45254	PR_EXT:000013059	denotes	PGC-1α
T29992	45279-45290	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T29993	45317-45322	GO:0007567	denotes	natal
T29994	45348-45363	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T29995	45390-45396	PR_EXT:000013059	denotes	PGC-1α
T29996	45396-45397	SO_EXT:sequence_nullness_or_absence	denotes	−
T29997	45398-45399	SO_EXT:sequence_nullness_or_absence	denotes	−
T29998	45400-45404	NCBITaxon:10088	denotes	mice
T29999	45541-45547	PR_EXT:000013059	denotes	PGC-1α
T30000	45547-45548	SO_EXT:sequence_nullness_or_absence	denotes	−
T30001	45549-45550	SO_EXT:sequence_nullness_or_absence	denotes	−
T30002	45551-45555	NCBITaxon:10088	denotes	mice
T30003	45599-45605	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T30004	45638-45645	UBERON:0000948	denotes	cardiac
T30005	45661-45667	PR_EXT:000013059	denotes	PGC-1α
T30006	45667-45668	SO_EXT:sequence_nullness_or_absence	denotes	−
T30007	45669-45670	SO_EXT:sequence_nullness_or_absence	denotes	−
T30008	45671-45675	NCBITaxon:10088	denotes	mice
T30009	45762-45767	UBERON:0000948	denotes	heart
T30010	45773-45781	GO_EXT:reaction_or_response	denotes	response
T30011	45827-45834	UBERON:0000948	denotes	cardiac
T30012	45835-45840	UBERON:0000948	denotes	heart
T30013	45867-45875	GO_EXT:reaction_or_response	denotes	response
T30014	45879-45891	GO_PR_EXT:beta_adrenergic_receptor	denotes	β-adrenergic
T30015	45967-45973	GO_EXT:biological_growth_entity_or_process	denotes	growth
T30016	46022-46032	GO:0008152	denotes	metabolism
T30017	46036-46046	UBERON:0002351	denotes	sinus node
T30018	46057-46063	PR_EXT:000013059	denotes	PGC-1α
T30019	46152-46158	PR_EXT:000013059	denotes	PGC-1α
T30020	46158-46159	SO_EXT:sequence_nullness_or_absence	denotes	−
T30021	46160-46161	SO_EXT:sequence_nullness_or_absence	denotes	−
T30022	46162-46166	NCBITaxon:10088	denotes	mice
T30023	46193-46204	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T30024	46250-46254	UBERON_EXT:body	denotes	body
T30025	46301-46314	GO:0031649	denotes	thermogenesis
T30026	46348-46353	PR_EXT:000017035	denotes	UCP-1
T30027	46354-46358	CHEBI_SO_EXT:mRNA	denotes	mRNA
T30028	46362-46365	UBERON:0001348	denotes	BAT
T30029	46382-46395	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3-adrenergic
T30030	46385-46403	CHEBI_EXT:37886	denotes	adrenergic agonist
T30031	46396-46403	CHEBI_GO_EXT:agonist	denotes	agonist
T30032	46428-46434	CHEBI_EXT:oxygen	denotes	oxygen
T30033	46455-46466	GO:0031649	denotes	thermogenic
T30034	46467-46473	UBERON:0000479	denotes	tissue
T30035	46491-46497	PR_EXT:000013059	denotes	PGC-1α
T30036	46497-46498	SO_EXT:sequence_nullness_or_absence	denotes	−
T30037	46499-46500	SO_EXT:sequence_nullness_or_absence	denotes	−
T30038	46501-46505	NCBITaxon:10088	denotes	mice
T30039	46527-46538	GO:0031649	denotes	thermogenic
T30040	46584-46597	GO:0005739	denotes	mitochondrial
T30041	46598-46609	GO:0045333	denotes	respiration
T30042	46613-46616	UBERON:0001348	denotes	BAT
T30043	46702-46707	GO:0007567	denotes	natal
T30044	46708-46712	UBERON:0000104	denotes	life
T30045	46714-46721	NCBITaxon:33208	denotes	Animals
T30046	46827-46831	UBERON_EXT:body	denotes	body
T30047	46896-46902	PR_EXT:000013059	denotes	PGC-1α
T30048	46926-46937	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T30049	46953-46963	_FRAGMENT	denotes	control of
T30050	46971-46981	GO:0019222	denotes	metabolism
T30051	47018-47025	UBERON:0002107	denotes	hepatic
T30052	47075-47081	PR_EXT:000013059	denotes	PGC-1α
T30053	47081-47082	SO_EXT:sequence_nullness_or_absence	denotes	−
T30054	47083-47084	SO_EXT:sequence_nullness_or_absence	denotes	−
T30055	47085-47089	NCBITaxon:10088	denotes	mice
T30056	47093-47100	GO_EXT:reaction_or_response	denotes	respond
T30057	47108-47113	GO:0007567	denotes	natal
T30058	47128-47137	GO:0008152	denotes	metabolic
T30059	47198-47204	PR_EXT:000013059	denotes	PGC-1α
T30060	47204-47205	SO_EXT:sequence_nullness_or_absence	denotes	−
T30061	47206-47207	SO_EXT:sequence_nullness_or_absence	denotes	−
T30062	47208-47212	NCBITaxon:10088	denotes	mice
T30063	47230-47240	CL:0000182	denotes	hepatocyte
T30064	47241-47253	CHEBI:17855	denotes	triglyceride
T30065	47299-47308	CHEBI:7896	denotes	palmitate
T30066	47309-47318	MOP:0000568	denotes	oxidation
T30067	47341-47352	CL:0000182	denotes	hepatocytes
T30068	47371-47377	PR_EXT:000013059	denotes	PGC-1α
T30069	47377-47378	SO_EXT:sequence_nullness_or_absence	denotes	−
T30070	47379-47380	SO_EXT:sequence_nullness_or_absence	denotes	−
T30071	47381-47385	NCBITaxon:10088	denotes	mice
T30072	47413-47418	CHEBI:18059	denotes	lipid
T30073	47464-47469	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T30074	47464-47474	CHEBI:35366	denotes	fatty acid
T30075	47464-47484	GO:0019395	denotes	fatty acid oxidation
T30076	47475-47484	MOP:0000568	denotes	oxidation
T30077	47494-47500	PR_EXT:000013059	denotes	PGC-1α
T30078	47501-47505	SO_EXT:sequence_nullness	denotes	null
T30079	47506-47517	CL:0000182	denotes	hepatocytes
T30080	47541-47551	GO:0010467	denotes	expression
T30081	47555-47561	PR_EXT:000013059	denotes	PGC-1α
T30082	47562-47566	PR_EXT:PPAR	denotes	PPAR
T30083	47574-47579	SO_EXT:0000704	denotes	genes
T30084	47592-47605	GO:0005739	denotes	mitochondrial
T30085	47606-47611	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T30086	47606-47616	CHEBI:35366	denotes	fatty acid
T30087	47606-47626	GO:0019395	denotes	fatty acid oxidation
T30088	47617-47626	MOP:0000568	denotes	oxidation
T30089	47637-47650	GO:0005739	denotes	mitochondrial
T30090	47651-47662	GO:0045333	denotes	respiratory
T30091	47713-47725	CHEBI:17855	denotes	triglyceride
T30092	47713-47735	GO:0019432	denotes	triglyceride synthesis
T30093	47770-47780	GO:0010467	denotes	expression
T30094	47784-47789	SO_EXT:0000704	denotes	genes
T30095	47790-47798	SO_EXT:sequence_coding_function	denotes	encoding
T30096	47799-47804	PR_EXT:000028988	denotes	SREBP
T30097	47812-47815	GO_PR_EXT:stearoyl_CoA_desaturase	denotes	SCD
T30098	47812-47817	PR_EXT:000015921	denotes	SCD-1
T30099	47823-47831	CHEBI_PR_EXT:protein	denotes	proteins
T30100	47839-47846	UBERON:0002107	denotes	hepatic
T30101	47847-47856	GO:0008610	denotes	lipogenic
T30102	47893-47907	GO_EXT:negative_regulation	denotes	down-regulated
T30103	47918-47924	PR_EXT:000013059	denotes	PGC-1α
T30104	47924-47925	SO_EXT:sequence_nullness_or_absence	denotes	−
T30105	47926-47927	SO_EXT:sequence_nullness_or_absence	denotes	−
T30106	47928-47932	NCBITaxon:10088	denotes	mice
T30107	48039-48051	CHEBI:17855	denotes	triglyceride
T30108	48039-48061	GO:0019432	denotes	triglyceride synthesis
T30109	48152-48160	GO_EXT:reaction_or_response	denotes	response
T30110	48197-48203	PR_EXT:000013059	denotes	PGC-1α
T30111	48225-48230	SO_EXT:0000704	denotes	genes
T30189	49947-49953	PR_EXT:000013059	denotes	PGC-1α
T30112	48259-48267	GO_EXT:reaction_or_response	denotes	response
T30113	48271-48281	CL:0000182	denotes	hepatocyte
T30114	48282-48287	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T30115	48282-48292	CHEBI:35366	denotes	fatty acid
T30116	48378-48384	PR_EXT:000013059	denotes	PGC-1α
T30117	48401-48408	GO:0005634	denotes	nuclear
T30118	48409-48417	GO_EXT:0004872	denotes	receptor
T30119	48418-48421	PR_EXT:000011396	denotes	FXR
T30120	48425-48443	GO_EXT:negative_regulator	denotes	negative regulator
T30121	48447-48452	PR_EXT:000028988	denotes	SREBP
T30122	48456-48466	GO:0010467	denotes	expression
T30123	48471-48483	CHEBI:17855	denotes	triglyceride
T30124	48471-48493	GO:0019432	denotes	triglyceride synthesis
T30125	48525-48535	CL:0000182	denotes	hepatocyte
T30126	48536-48549	GO:0005739	denotes	mitochondrial
T30127	48550-48561	GO:0045333	denotes	respiratory
T30128	48599-48608	GO:0008610	denotes	lipogenic
T30129	48629-48639	CL:0000182	denotes	hepatocyte
T30130	48640-48652	CHEBI:17855	denotes	triglyceride
T30131	48694-48701	UBERON:0002107	denotes	hepatic
T30132	48702-48725	GO:0015908	denotes	delivery of fatty acids
T30133	48714-48719	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T30134	48714-48725	CHEBI:35366	denotes	fatty acids
T30135	48789-48795	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T30136	48796-48802	PR_EXT:000013059	denotes	PGC-1α
T30137	48802-48803	SO_EXT:sequence_nullness_or_absence	denotes	−
T30138	48804-48805	SO_EXT:sequence_nullness_or_absence	denotes	−
T30139	48806-48810	NCBITaxon:10088	denotes	mice
T30140	48895-48898	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30141	48973-48978	GO:0007568	denotes	aging
T30142	49017-49021	UBERON_EXT:body	denotes	body
T30143	49022-49025	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30144	49044-49048	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T30145	49049-49055	PR_EXT:000013059	denotes	PGC-1α
T30146	49055-49056	SO_EXT:sequence_nullness_or_absence	denotes	−
T30147	49057-49058	SO_EXT:sequence_nullness_or_absence	denotes	−
T30148	49059-49063	NCBITaxon:10088	denotes	mice
T30149	49135-49142	GO:0065007	denotes	control
T30150	49186-49190	CHEBI_EXT:33290	denotes	food
T30151	49186-49197	GO:0007631	denotes	food intake
T30152	49220-49226	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T30153	49227-49233	PR_EXT:000013059	denotes	PGC-1α
T30154	49233-49234	SO_EXT:sequence_nullness_or_absence	denotes	−
T30155	49235-49236	SO_EXT:sequence_nullness_or_absence	denotes	−
T30156	49237-49241	NCBITaxon:10088	denotes	mice
T30157	49322-49335	GO:0005739	denotes	mitochondrial
T30158	49368-49371	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30159	49400-49406	PR_EXT:000013059	denotes	PGC-1α
T30160	49406-49407	SO_EXT:sequence_nullness_or_absence	denotes	−
T30161	49408-49409	SO_EXT:sequence_nullness_or_absence	denotes	−
T30162	49410-49414	NCBITaxon:10088	denotes	mice
T30163	49454-49460	PR_EXT:000013059	denotes	PGC-1α
T30164	49461-49465	SO_EXT:0000704	denotes	gene
T30165	49466-49479	SO_EXT:polymorphism	denotes	polymorphisms
T30166	49495-49501	NCBITaxon:9606	denotes	humans
T30167	49562-49566	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T30168	49571-49577	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T30169	49578-49584	PR_EXT:000013059	denotes	PGC-1α
T30170	49584-49585	SO_EXT:sequence_nullness_or_absence	denotes	−
T30171	49586-49587	SO_EXT:sequence_nullness_or_absence	denotes	−
T30172	49588-49592	NCBITaxon:10088	denotes	mice
T30173	49717-49724	GO:0065007	denotes	control
T30174	49729-49732	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30175	49776-49783	CHEBI:17234	denotes	glucose
T30176	49799-49806	PR_EXT:000045358	denotes	insulin
T30177	49825-49831	PR_EXT:000013059	denotes	PGC-1α
T30178	49831-49832	SO_EXT:sequence_nullness_or_absence	denotes	−
T30179	49833-49834	SO_EXT:sequence_nullness_or_absence	denotes	−
T30180	49835-49842	NCBITaxon:33208	denotes	animals
T30181	49855-49859	CHEBI_EXT:33290	denotes	chow
T30182	49871-49877	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T30183	49878-49884	PR_EXT:000013059	denotes	PGC-1α
T30184	49884-49885	SO_EXT:sequence_nullness_or_absence	denotes	−
T30185	49886-49887	SO_EXT:sequence_nullness_or_absence	denotes	−
T30186	49888-49892	NCBITaxon:10088	denotes	mice
T30187	49903-49910	CHEBI:17234	denotes	glucose
T30188	49924-49931	PR_EXT:000045358	denotes	insulin
T30190	49953-49954	SO_EXT:normal_or_wild_type_or_present	denotes	+
T30191	49955-49956	SO_EXT:normal_or_wild_type_or_present	denotes	+
T30192	49971-49980	GO:0007631	denotes	consuming
T30193	49988-49991	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30194	50095-50105	GO:0010467	denotes	expression
T30195	50109-50115	PR_EXT:000013059	denotes	PGC-1α
T30196	50119-50124	NCBITaxon:9606	denotes	human
T30197	50134-50149	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T30198	50202-50222	GO:0019222	denotes	metabolic regulatory
T30199	50261-50267	PR_EXT:000013059	denotes	PGC-1α
T30200	50278-50282	NCBITaxon:10088	denotes	mice
T30201	50332-50338	PR_EXT:000013059	denotes	PGC-1α
T30202	50405-50412	PR_EXT:000045358	denotes	insulin
T30203	50484-50488	NCBITaxon:10088	denotes	mice
T30204	50501-50507	PR_EXT:000013059	denotes	PGC-1α
T30205	50515-50519	PR_EXT:PPAR	denotes	PPAR
T30206	50555-50562	CHEBI:17234	denotes	glucose
T30207	50613-50619	PR_EXT:000013059	denotes	PGC-1α
T30208	50619-50620	SO_EXT:sequence_nullness_or_absence	denotes	−
T30209	50621-50622	SO_EXT:sequence_nullness_or_absence	denotes	−
T30210	50623-50627	NCBITaxon:10088	denotes	mice
T30211	50674-50696	UBERON:0001017	denotes	central nervous system
T30212	50739-50745	UBERON:0000955	denotes	brains
T30213	50749-50755	PR_EXT:000013059	denotes	PGC-1α
T30214	50755-50756	SO_EXT:sequence_nullness_or_absence	denotes	−
T30215	50757-50758	SO_EXT:sequence_nullness_or_absence	denotes	−
T30216	50759-50763	NCBITaxon:10088	denotes	mice
T30217	50813-50830	CL:0000598	denotes	pyramidal neurons
T30218	50823-50833	_FRAGMENT	denotes	neurons of
T30219	50838-50853	CL:0010012	denotes	cerebral cortex
T30220	50838-50853	UBERON:0000956	denotes	cerebral cortex
T30221	50903-50913	CL:0000127	denotes	astrocytes
T30222	50921-50934	UBERON:0002420	denotes	basal ganglia
T30223	51034-51040	PR_EXT:000013059	denotes	PGC-1α
T30224	51068-51073	CHEBI:18059	denotes	lipid
T30225	51068-51084	GO:0006629	denotes	lipid metabolism
T30226	51096-51104	GO:0016020	denotes	membrane
T30227	51096-51114	GO:0044091	denotes	membrane synthesis
T30228	51153-51161	CL_GO_EXT:cell	denotes	cellular
T30229	51236-51246	CL:0000129	denotes	microglial
T30230	51264-51286	UBERON:0001017	denotes	central nervous system
T30231	51303-51313	UBERON:0001016	denotes	neurologic
T30232	51346-51352	PR_EXT:000013059	denotes	PGC-1α
T30233	51352-51353	SO_EXT:sequence_nullness_or_absence	denotes	−
T30234	51354-51355	SO_EXT:sequence_nullness_or_absence	denotes	−
T30235	51356-51360	NCBITaxon:10088	denotes	mice
T30236	51386-51390	UBERON:0000104	denotes	life
T30237	51439-51451	UBERON:0025534	denotes	sensorimotor
T30238	51464-51470	PR_EXT:000013059	denotes	PGC-1α
T30239	51470-51471	SO_EXT:sequence_nullness_or_absence	denotes	−
T30240	51472-51473	SO_EXT:sequence_nullness_or_absence	denotes	−
T30241	51474-51478	NCBITaxon:10088	denotes	mice
T30242	51572-51578	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T30243	51595-51601	PR_EXT:000013059	denotes	PGC-1α
T30244	51601-51602	SO_EXT:sequence_nullness_or_absence	denotes	−
T30245	51603-51604	SO_EXT:sequence_nullness_or_absence	denotes	−
T30246	51605-51609	NCBITaxon:10088	denotes	mice
T30247	51632-51642	_FRAGMENT	denotes	peripheral
T30248	51654-51668	UBERON:0000010	denotes	nervous system
T30249	51646-51668	UBERON:0001017	denotes	central nervous system
T30250	51771-51780	GO:0040011	denotes	locomotor
T30251	51836-51841	UBERON:0000955	denotes	brain
T30252	51854-51860	PR_EXT:000013059	denotes	PGC-1α
T30253	51860-51861	SO_EXT:sequence_nullness_or_absence	denotes	−
T30254	51862-51863	SO_EXT:sequence_nullness_or_absence	denotes	−
T30255	51864-51868	NCBITaxon:10088	denotes	mice
T30256	51918-51928	UBERON:0001016	denotes	neurologic
T30257	51970-51979	GO:0008152	denotes	metabolic
T30258	52001-52007	PR_EXT:000013059	denotes	PGC-1α
T30259	52008-52012	SO_EXT:sequence_nullness	denotes	null
T30260	52013-52017	NCBITaxon:10088	denotes	mice
T30261	52097-52102	NCBITaxon:10088	denotes	mouse
T30262	52121-52127	PR_EXT:000013059	denotes	PGC-1α
T30263	52128-52132	SO_EXT:0000704	denotes	gene
T30264	52185-52191	PR_EXT:000013059	denotes	PGC-1α
T30265	52306-52312	PR_EXT:000013059	denotes	PGC-1α
T30266	52363-52373	CL:0000182	denotes	hepatocyte
T30267	52374-52385	GO:0045333	denotes	respiration
T30268	52397-52407	UBERON:0001016	denotes	neurologic
T30269	52513-52519	PR_EXT:000013059	denotes	PGC-1α
T30270	52519-52520	SO_EXT:sequence_nullness_or_absence	denotes	−
T30271	52521-52522	SO_EXT:sequence_nullness_or_absence	denotes	−
T30272	52523-52527	NCBITaxon:10088	denotes	mice
T30273	52566-52571	GO:0007567	denotes	natal
T30274	52632-52647	GO:0006094	denotes	gluconeogenesis
T30275	52665-52670	UBERON:0000178	denotes	blood
T30276	52671-52678	CHEBI:17234	denotes	glucose
T30277	52756-52766	GO:0010467	denotes	expression
T30278	52779-52811	PR_EXT:000005308	denotes	CCAAT-enhancer-binding protein β
T30279	52779-52809	_FRAGMENT	denotes	CCAAT-enhancer-binding protein
T30280	52816-52817	PR_EXT:000005309	denotes	δ
T30281	52785-52793	SO_EXT:0000165	denotes	enhancer
T30282	52794-52801	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T30283	52802-52809	CHEBI_PR_EXT:protein	denotes	protein
T30284	52826-52839	GO:0006094	denotes	gluconeogenic
T30285	52840-52845	SO_EXT:0000704	denotes	genes
T30286	52846-52854	SO_EXT:sequence_coding_function	denotes	encoding
T30287	52855-52874	CHEBI:18021	denotes	phosphoenolpyruvate
T30288	52855-52888	GO_PR_EXT:phosphoenolpyruvate_carboxykinase	denotes	phosphoenolpyruvate carboxykinase
T30289	52893-52900	CHEBI:17234	denotes	glucose
T30290	52893-52914	GO_PR_EXT:glucose_6_phosphatase	denotes	glucose-6-phosphatase
T30291	52951-52957	PR_EXT:000013059	denotes	PGC-1α
T30292	52957-52958	SO_EXT:sequence_nullness_or_absence	denotes	−
T30293	52959-52960	SO_EXT:sequence_nullness_or_absence	denotes	−
T30294	52961-52965	NCBITaxon:10088	denotes	mice
T30295	53054-53058	UBERON_EXT:body	denotes	body
T30296	53059-53062	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30297	53066-53072	PR_EXT:000013059	denotes	PGC-1α
T30298	53072-53073	SO_EXT:sequence_nullness_or_absence	denotes	−
T30299	53074-53075	SO_EXT:sequence_nullness_or_absence	denotes	−
T30300	53076-53080	NCBITaxon:10088	denotes	mice
T30301	53082-53089	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T30302	53103-53108	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T30303	53143-53147	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T30304	53196-53203	PR_EXT:000045358	denotes	insulin
T30305	53240-53244	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T30306	53245-53251	PR_EXT:000013059	denotes	PGC-1α
T30307	53262-53266	NCBITaxon:10088	denotes	mice
T30308	53362-53369	PR_EXT:000045358	denotes	insulin
T30309	53397-53403	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T30310	53404-53410	PR_EXT:000013059	denotes	PGC-1α
T30311	53410-53411	SO_EXT:sequence_nullness_or_absence	denotes	−
T30312	53412-53413	SO_EXT:sequence_nullness_or_absence	denotes	−
T30313	53414-53418	NCBITaxon:10088	denotes	mice
T30314	53475-53478	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T30315	53524-53531	PR_EXT:000045358	denotes	insulin
T30316	53555-53561	PR_EXT:000013059	denotes	PGC-1α
T30317	53561-53562	SO_EXT:sequence_nullness_or_absence	denotes	−
T30318	53563-53564	SO_EXT:sequence_nullness_or_absence	denotes	−
T30319	53565-53569	NCBITaxon:10088	denotes	mice
T30320	53630-53634	NCBITaxon:10088	denotes	mice
T30321	53647-53654	GO:0005634	denotes	nuclear
T30322	53655-53663	GO_EXT:0004872	denotes	receptor
T30323	53664-53672	CHEBI_EXT:50114	denotes	estrogen
T30324	53664-53691	PR_EXT:000007208	denotes	estrogen-related receptor α
T30325	53681-53689	GO_EXT:0004872	denotes	receptor
T30326	53711-53717	PR_EXT:000013059	denotes	PGC-1α
T30327	53781-53785	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T30328	53786-53792	PR_EXT:000013059	denotes	PGC-1α
T30329	53793-53797	SO_EXT:sequence_nullness	denotes	null
T30330	53798-53802	NCBITaxon:10088	denotes	mice
T30331	53821-53827	PR_EXT:000013059	denotes	PGC-1α
T30332	53827-53828	SO_EXT:sequence_nullness_or_absence	denotes	−
T30333	53829-53830	SO_EXT:sequence_nullness_or_absence	denotes	−
T30334	53831-53835	NCBITaxon:10088	denotes	mice
T30335	53886-53893	UBERON:0002107	denotes	hepatic
T30336	53938-53943	NCBITaxon:10088	denotes	mouse
T30337	53980-53990	UBERON:0001016	denotes	neurologic
T30338	54004-54009	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T30339	54054-54060	PR_EXT:000013059	denotes	PGC-1α
T30340	54060-54061	SO_EXT:sequence_nullness_or_absence	denotes	−
T30341	54062-54063	SO_EXT:sequence_nullness_or_absence	denotes	−
T30342	54064-54068	NCBITaxon:10088	denotes	mice
T30343	54097-54106	GO:0040011	denotes	locomotor
T30344	54218-54223	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T30345	54341-54348	NCBITaxon:33208	denotes	animals
T30346	54413-54428	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T30347	54433-54440	UBERON:0000948	denotes	cardiac
T30348	54641-54647	PR_EXT:000013059	denotes	PGC-1α
T30349	54658-54663	NCBITaxon:10088	denotes	mouse
T30350	54714-54721	SO_EXT:0000704	denotes	genetic
T30351	54811-54820	GO_EXT:reaction_or_response	denotes	responses
T30352	54866-54871	GO:0007567	denotes	natal
T30353	54895-54901	PR_EXT:000013059	denotes	PGC-1α
T30354	54901-54902	SO_EXT:sequence_nullness_or_absence	denotes	−
T30355	54903-54904	SO_EXT:sequence_nullness_or_absence	denotes	−
T30356	54905-54909	NCBITaxon:10088	denotes	mice
T30357	55011-55020	GO_EXT:reaction_or_response	denotes	responses
T30358	55024-55029	UBERON:0002107	denotes	liver
T30359	55040-55047	UBERON:0000479	denotes	tissues
T30360	55111-55115	SO_EXT:0000704	denotes	gene
T30361	55176-55182	PR_EXT:000013059	denotes	PGC-1α
T30362	55182-55183	SO_EXT:sequence_nullness_or_absence	denotes	−
T30363	55184-55185	SO_EXT:sequence_nullness_or_absence	denotes	−
T30364	55186-55190	NCBITaxon:10088	denotes	mice
T30365	55198-55209	GO_EXT:recombinase	denotes	recombinase
T30366	55219-55227	SO_EXT:sequence_deletion_process	denotes	excision
T30367	55231-55236	SO_EXT:0000147	denotes	exons
T30368	55244-55251	CL:0000023	denotes	oocytes
T30369	55257-55263	PR_EXT:000013059	denotes	PGC-1α
T30370	55263-55264	SO_EXT:sequence_nullness_or_absence	denotes	−
T30371	55265-55266	SO_EXT:sequence_nullness_or_absence	denotes	−
T30372	55267-55271	NCBITaxon:10088	denotes	mice
T30373	55353-55366	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T30374	55381-55390	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T30375	55398-55414	SO_EXT:0001644	denotes	targeting vector
T30376	55434-55438	SO_EXT:0000147	denotes	exon
T30377	55449-55454	SO_EXT:0000147	denotes	exons
T30378	55468-55472	SO_EXT:0000147	denotes	exon
T30379	55475-55484	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T30380	55509-55511	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T30381	55530-55536	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30382	55537-55547	SO_EXT:0000673	denotes	transcript
T30383	55553-55560	SO_EXT:sequence_coding_function	denotes	encodes
T30384	55563-55572	SO_EXT:sequence_truncation_process	denotes	truncated
T30385	55573-55580	CHEBI_PR_EXT:protein	denotes	protein
T30386	55614-55624	SO_EXT:0000673	denotes	transcript
T30387	55639-55643	_FRAGMENT	denotes	exon
T30388	55648-55654	SO_EXT:0000333	denotes	border
T30389	55769-55775	PR_EXT:000013059	denotes	PGC-1α
T30390	55776-55784	CHEBI_PR_EXT:protein	denotes	proteins
T30391	55941-55947	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T30392	55949-55958	SO_EXT:sequence_truncation_process	denotes	truncated
T30393	55960-55966	PR_EXT:000013059	denotes	PGC-1α
T30394	55967-55974	CHEBI_PR_EXT:protein	denotes	protein
T30395	56034-56041	GO:0005634	denotes	nuclear
T30396	56042-56050	GO_EXT:0004872	denotes	receptor
T30397	56063-56070	SO_EXT:0000417	denotes	domains
T30398	56079-56093	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	amino-terminal
T30399	56105-56111	SO_EXT:0000417	denotes	domain
T30400	56133-56139	PR_EXT:000013059	denotes	PGC-1α
T30401	56168-56172	NCBITaxon:10088	denotes	mice
T30402	56331-56337	PR_EXT:000013059	denotes	PGC-1α
T30403	56337-56338	SO_EXT:sequence_nullness_or_absence	denotes	−
T30404	56339-56340	SO_EXT:sequence_nullness_or_absence	denotes	−
T30405	56341-56345	NCBITaxon:10088	denotes	mice
T30406	56384-56390	PR_EXT:000013059	denotes	PGC-1α
T30407	56428-56433	NCBITaxon:10088	denotes	mouse
T30408	56541-56547	PR_EXT:000013059	denotes	PGC-lα
T30409	56568-56586	GO:0051866	denotes	adaptive responses
T30410	56609-56614	GO:0007567	denotes	natal
T34021	57589-57595	PR_EXT:000013059	denotes	PGC-1α
T34022	57596-57600	SO_EXT:0000704	denotes	gene
T34023	57604-57608	NCBITaxon:10088	denotes	mice
T34024	57611-57614	SO_EXT:0000153	denotes	BAC
T34025	57615-57628	SO_EXT:0000040	denotes	genomic clone
T34026	57644-57650	NCBITaxon:39107	denotes	murine
T34027	57651-57657	PR_EXT:000013059	denotes	PGC-1α
T34028	57658-57662	SO_EXT:0000704	denotes	gene
T34029	57687-57694	SO_EXT:0001026	denotes	genomic
T34030	57783-57784	CHEBI_SO_EXT:base	denotes	b
T34031	57801-57805	SO_EXT:0000147	denotes	exon
T34032	57831-57844	SO_EXT:0000040	denotes	genomic clone
T34033	57848-57857	SO_EXT:0000121	denotes	5′ primer
T34034	57923-57925	SO_EXT:0000028	denotes	bp
T34035	57926-57934	SO_EXT:sequence_upstreamness	denotes	upstream
T34036	57938-57942	SO_EXT:0000147	denotes	exon
T34037	57950-57958	SO_EXT:sequence_upstreamness	denotes	upstream
T34038	57981-57997	SO_EXT:0000061	denotes	restriction site
T34039	58034-58043	SO_EXT:0000132	denotes	3′ primer
T34040	58056-58061	PR_EXT:P23940	denotes	BamH1
T34041	58081-58089	SO_EXT:sequence_alteration_process	denotes	mutating
T34042	58094-58099	CHEBI_SO_EXT:base	denotes	bases
T34043	58171-58181	SO_EXT:sequence_downstreamness	denotes	downstream
T34044	58185-58189	SO_EXT:0000147	denotes	exon
T34045	58277-58279	_FRAGMENT	denotes	5′
T34046	58287-58294	SO_EXT:0000121	denotes	primers
T34047	58284-58294	SO_EXT:0000132	denotes	3′ primers
T34048	58395-58401	SO_EXT:sequence_cloning_process	denotes	cloned
T34049	58413-58416	GO_EXT:phosphoglycerate_kinase	denotes	PGK
T34050	58426-58442	SO_EXT:0001644	denotes	targeting vector
T34051	58448-58457	SO_EXT:engineered_biological_sequence	denotes	construct
T34052	58462-58472	SO_EXT:sequence_linearization	denotes	linearized
T34053	58511-58519	CL:0002322	denotes	ES cells
T34054	58514-58519	CL_GO_EXT:cell	denotes	cells
T34055	58542-58546	CHEBI:42768	denotes	G418
T34056	58621-58628	CL:0002322	denotes	ES Cell
T34057	58624-58628	CL_GO_EXT:cell	denotes	Cell
T34058	58701-58707	SO_EXT:sequence_cloned_entity	denotes	clones
T34059	58788-58793	SO_EXT:sequence_cloned_entity	denotes	clone
T34060	58860-58873	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T34061	58895-58904	SO_EXT:sequence_insertion_entity_or_process	denotes	insertion
T34062	58925-58930	SO_EXT:sequence_cloned_entity	denotes	clone
T34063	58960-58970	UBERON:0000358	denotes	blastocyst
T34064	58986-58991	GO:0007618	denotes	mated
T34065	59004-59008	NCBITaxon:10088	denotes	mice
T34066	59073-59077	UBERON:0002415	denotes	tail
T34067	59078-59081	CHEBI_SO_EXT:DNA	denotes	DNA
T35360	59199-59205	NCBITaxon:33208	denotes	animal
T35361	59218-59224	NCBITaxon:33208	denotes	animal
T35362	59372-59379	NCBITaxon:33208	denotes	animals
T35363	59418-59424	NCBITaxon:33208	denotes	Animal
T35364	59466-59473	NCBITaxon:33208	denotes	Animals
T35365	59513-59517	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T35366	59522-59528	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T35367	59544-59550	PR_EXT:000013059	denotes	PGC-1α
T35368	59550-59551	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35369	59552-59553	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35370	59558-59564	PR_EXT:000013059	denotes	PGC-1α
T35371	59564-59565	SO_EXT:sequence_nullness_or_absence	denotes	−
T35372	59566-59567	SO_EXT:sequence_nullness_or_absence	denotes	−
T35373	59568-59572	NCBITaxon:10088	denotes	mice
T35374	59594-59601	UBERON:0000479	denotes	tissues
T35375	59655-59661	UBERON:0000479	denotes	Tissue
T35376	59695-59699	UBERON_EXT:body	denotes	body
T35377	59841-59845	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T35378	59850-59856	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T35379	59857-59863	PR_EXT:000013059	denotes	PGC-1α
T35380	59863-59864	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35381	59865-59866	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35382	59871-59877	PR_EXT:000013059	denotes	PGC-1α
T35383	59877-59878	SO_EXT:sequence_nullness_or_absence	denotes	−
T35384	59879-59880	SO_EXT:sequence_nullness_or_absence	denotes	−
T35385	59881-59885	NCBITaxon:10088	denotes	mice
T35386	59918-59922	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T35387	59927-59933	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T35388	59934-59940	PR_EXT:000013059	denotes	PGC-1α
T35389	59940-59941	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35390	59942-59943	SO_EXT:normal_or_wild_type_or_present	denotes	+
T35391	59948-59954	PR_EXT:000013059	denotes	PGC-1α
T35392	59954-59955	SO_EXT:sequence_nullness_or_absence	denotes	−
T35393	59956-59957	SO_EXT:sequence_nullness_or_absence	denotes	−
T35394	59958-59962	NCBITaxon:10088	denotes	mice
T35395	60017-60021	CHEBI_EXT:33290	denotes	food
T35396	60028-60032	UBERON_EXT:body	denotes	body
T35397	60064-60070	UBERON:0001052	denotes	rectal
T35398	60116-60120	NCBITaxon:10088	denotes	Mice
T35399	60200-60204	NCBITaxon:10088	denotes	mice
T35400	60210-60220	GO_EXT:killing	denotes	sacrificed
T35401	60225-60232	UBERON:0000479	denotes	tissues
T35402	60247-60250	CHEBI_SO_EXT:RNA	denotes	RNA
T35403	60255-60262	CHEBI_PR_EXT:protein	denotes	protein
T35404	60296-60303	NCBITaxon:33208	denotes	animals
T35405	60333-60338	CHEBI:15377	denotes	water
T35406	60351-60355	CHEBI_EXT:33290	denotes	Food
T35407	60398-60405	UBERON:0000479	denotes	tissues
T35408	60428-60431	CHEBI_SO_EXT:RNA	denotes	RNA
T35409	60466-60470	NCBITaxon:10088	denotes	mice
T35410	60697-60703	NCBITaxon:33208	denotes	Animal
T35411	60802-60808	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T35412	60809-60813	NCBITaxon:10088	denotes	mice
T35413	61005-61014	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T36723	61017-61020	CHEBI_SO_EXT:RNA	denotes	RNA
T36724	61022-61025	CHEBI_SO_EXT:DNA	denotes	DNA
T36725	61031-61038	CHEBI_PR_EXT:protein	denotes	protein
T36726	61054-61057	CHEBI_SO_EXT:RNA	denotes	RNA
T36727	61193-61199	PR_EXT:000013060	denotes	PGC-1β
T36728	61204-61207	PR_EXT:000013159	denotes	PRC
T36729	61208-61213	SO_EXT:cDNA	denotes	cDNAs
T36730	61297-61302	PR_EXT:000017035	denotes	UCP-1
T36731	61303-61307	SO_EXT:cDNA	denotes	cDNA
T36732	61341-61343	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T36733	61397-61400	CHEBI_SO_EXT:RNA	denotes	RNA
T36734	61415-61428	UBERON:0001389	denotes	soleus muscle
T36735	61430-61433	UBERON:0001348	denotes	BAT
T36736	61439-61444	UBERON:0000948	denotes	heart
T36737	61459-61465	PR_EXT:000013059	denotes	PGC-1α
T36738	61465-61466	SO_EXT:normal_or_wild_type_or_present	denotes	+
T36739	61467-61468	SO_EXT:normal_or_wild_type_or_present	denotes	+
T36740	61472-61476	PR_EXT:000013059	denotes	PGCα
T36741	61476-61477	SO_EXT:sequence_nullness_or_absence	denotes	−
T36742	61478-61479	SO_EXT:sequence_nullness_or_absence	denotes	−
T36743	61480-61484	NCBITaxon:10088	denotes	mice
T36744	61489-61508	GO:0001171	denotes	reverse transcribed
T36745	61521-61542	GO:0001171	denotes	reverse transcription
T36746	61543-61551	CHEBI_EXT:33893	denotes	reagents
T36747	61689-61697	CHEBI_EXT:33893	denotes	reagents
T36748	61715-61723	SO_EXT:biological_sequence	denotes	Sequence
T36749	61759-61764	NCBITaxon:10088	denotes	mouse
T36750	61774-61780	SO_EXT:0000112	denotes	primer
T36751	61781-61786	CHEBI_SO_EXT:molecular_probe	denotes	probe
T36752	61816-61820	SO_EXT:0000704	denotes	gene
T36753	61816-61831	GO:0010467	denotes	gene expression
T36754	61862-61869	SO_EXT:0000112	denotes	primers
T36755	61874-61879	PR_EXT:000017035	denotes	UCP-1
T36756	61923-61929	SO_EXT:0000112	denotes	primer
T36757	61930-61935	CHEBI_SO_EXT:molecular_probe	denotes	probe
T36758	62019-62025	UBERON:0001389	denotes	soleus
T36759	62027-62030	UBERON:0001348	denotes	BAT
T36760	62036-62041	UBERON:0000948	denotes	heart
T36761	62042-62046	SO_EXT:0000704	denotes	gene
T36762	62042-62057	GO:0010467	denotes	gene expression
T36763	62064-62069	GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase	denotes	GAPDH
T36764	62070-62076	NCBITaxon:9989	denotes	Rodent
T36765	62077-62084	SO_EXT:0000112	denotes	primers
T36766	62150-62155	UBERON:0002107	denotes	liver
T36767	62156-62160	SO_EXT:0000704	denotes	gene
T36768	62156-62171	GO:0010467	denotes	gene expression
T36769	62213-62224	SO_EXT:genomic_DNA	denotes	genomic DNA
T36770	62221-62224	CHEBI_SO_EXT:DNA	denotes	DNA
T36771	62295-62306	GO_EXT:biological_movement_or_translocation_process	denotes	transferred
T36772	62312-62316	SO_EXT:0000704	denotes	Gene
T36773	62390-62403	GO:0097617	denotes	hybridization
T38145	62680-62693	GO:0005739	denotes	Mitochondrial
T38146	62694-62705	GO:0045333	denotes	respiration
T38147	62714-62727	GO:0005739	denotes	Mitochondrial
T38148	62728-62739	GO:0045333	denotes	respiration
T38149	62756-62763	CHEBI:26605	denotes	saponin
T38150	62772-62778	UBERON:0001389	denotes	soleus
T38151	62791-62800	CHEBI_EXT:succinate	denotes	succinate
T38152	62837-62845	CHEBI:28201	denotes	rotenone
T38153	62895-62901	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T38154	62902-62906	NCBITaxon:10088	denotes	mice
T38155	62912-62924	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T38156	62930-62945	CHEBI:28142	denotes	chloral hydrate
T38157	62960-62964	UBERON_EXT:body	denotes	body
T38158	62974-62980	UBERON:0001389	denotes	Soleus
T38159	63012-63023	GO_EXT:biological_movement_or_translocation_process	denotes	transferred
T38160	63029-63035	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T38161	63050-63054	CHEBI_EXT:EGTA	denotes	EGTA
T38162	63080-63085	CHEBI:6636	denotes	MgCl2
T38163	63093-63102	CHEBI:14434	denotes	imidazole
T38164	63112-63113	CHEBI_EXT:potassium	denotes	K
T38165	63114-63117	CHEBI:39010	denotes	MES
T38166	63125-63132	CHEBI:15891	denotes	taurine
T38167	63141-63144	CHEBI_EXT:ATP	denotes	ATP
T38168	63152-63155	CHEBI:17287	denotes	PCr
T38169	63162-63168	CHEBI:63036	denotes	KH2PO4
T38170	63177-63180	CHEBI:18320	denotes	DTT
T38171	63218-63225	CHEBI:26605	denotes	saponin
T38172	63345-63349	CHEBI_EXT:EGTA	denotes	EGTA
T38173	63375-63380	CHEBI:6636	denotes	MgCl2
T38174	63388-63397	CHEBI:14434	denotes	imidazole
T38175	63406-63407	CHEBI_EXT:potassium	denotes	K
T38176	63408-63411	CHEBI:39010	denotes	MES
T38177	63419-63426	CHEBI:15891	denotes	taurine
T38178	63433-63439	CHEBI:63036	denotes	KH2PO4
T38179	63448-63451	CHEBI:18320	denotes	DTT
T38180	63476-63487	GO:0045333	denotes	Respiration
T38181	63534-63540	CHEBI_EXT:oxygen	denotes	Oxygen
T38182	63640-63651	GO:0045333	denotes	respiration
T38183	63662-63665	CHEBI_EXT:ADP	denotes	ADP
T38184	63686-63697	GO:0045333	denotes	respiration
T38185	63740-63743	CHEBI_EXT:ADP	denotes	ADP
T38186	63766-63794	GO:0005741	denotes	outer mitochondrial membrane
T38187	63833-63845	PR_EXT:000002199	denotes	cytochrome c
T38188	63833-63845	CHEBI:18070	denotes	cytochrome c
T38189	63849-63852	CHEBI_EXT:ADP	denotes	ADP
T38190	63880-63891	GO:0045333	denotes	respiration
T38191	63940-63950	CHEBI:25675	denotes	oligomycin
T38192	63980-63986	CHEBI_EXT:oxygen	denotes	oxygen
T38193	63994-64005	GO:0045333	denotes	respiration
T38194	64006-64012	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T38195	64047-64049	CHEBI:15379	denotes	O2
T38196	64058-64069	GO:0045333	denotes	Respiration
T38197	64099-64101	CHEBI:15379	denotes	O2
T38931	64169-64176	PR_EXT:000045358	denotes	Insulin
T38932	64245-64249	NCBITaxon:10088	denotes	mice
T38933	64308-64312	NCBITaxon:10088	denotes	mice
T38934	64338-64346	CHEBI:75958	denotes	solution
T38935	64350-64359	CHEBI:17634	denotes	D-glucose
T38936	64379-64383	NCBITaxon:10088	denotes	mice
T38937	64412-64417	NCBITaxon:9606	denotes	human
T38938	64412-64417	_FRAGMENT	denotes	human
T38939	64426-64433	CHEBI:5931	denotes	insulin
T38940	64426-64433	PR_EXT:000045358	denotes	insulin
T38941	64514-64518	UBERON_EXT:body	denotes	body
T38942	64527-64531	UBERON:0002415	denotes	Tail
T38943	64538-64545	CHEBI:17234	denotes	glucose
T38944	64613-64620	CHEBI:17234	denotes	GLUCOSE
T40013	65153-65161	CHEBI:10545	denotes	electron
T40014	65173-65186	UBERON:0001389	denotes	Soleus muscle
T40015	65191-65196	UBERON:0002107	denotes	liver
T40016	65238-65252	CHEBI:64276	denotes	glutaraldehyde
T40017	65257-65273	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T40018	65285-65302	CHEBI:62956	denotes	sodium cacodylate
T40019	65303-65309	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T40020	65315-65322	UBERON:0000479	denotes	tissues
T40021	65383-65390	CHEBI:16236	denotes	ethanol
T40022	65446-65454	CHEBI:10545	denotes	electron
T40023	65467-65474	_FRAGMENT	denotes	Cardiac
T40024	65488-65494	UBERON:0001133	denotes	muscle
T40025	65479-65494	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T40026	65495-65508	GO:0005739	denotes	mitochondrial
T40027	65513-65525	GO:0030016	denotes	myofibrillar
T40028	65564-65572	CHEBI:10545	denotes	electron
T40029	65624-65630	NCBITaxon:33208	denotes	animal
T40030	65767-65779	GO:0005739	denotes	mitochondria
T40031	65783-65793	GO:0030016	denotes	myofibrils
T40032	65813-65821	CHEBI:10545	denotes	electron
T40033	65850-65855	UBERON:0000955	denotes	brain
T40034	65857-65863	UBERON:0000479	denotes	tissue
T40035	65929-65935	UBERON:0001851	denotes	cortex
T40036	66008-66012	CHEBI_EXT:lead	denotes	lead
T40037	66013-66020	CHEBI_EXT:citrate	denotes	citrate
T40038	66051-66059	CHEBI:10545	denotes	electron
T40039	66076-66077	CHEBI:51686	denotes	H
T40040	66078-66079	CHEBI_EXT:eosin	denotes	E
T40041	66102-66107	UBERON:0000955	denotes	brain
T40042	66119-66134	UBERON:0000956	denotes	cerebral cortex
T40043	66136-66145	UBERON:0002298	denotes	brainstem
T40044	66151-66161	UBERON:0002037	denotes	cerebellum
T40045	66207-66214	CHEBI:30879	denotes	alcohol
T40723	66289-66294	NCBITaxon:10088	denotes	mouse
T40724	66295-66305	CL:0000182	denotes	hepatocyte
T40725	66334-66339	NCBITaxon:10088	denotes	mouse
T40726	66340-66351	CL:0000182	denotes	hepatocytes
T40727	66371-66375	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T40728	66376-66382	PR_EXT:000013059	denotes	PGC-1α
T40729	66382-66383	SO_EXT:normal_or_wild_type_or_present	denotes	+
T40730	66384-66385	SO_EXT:normal_or_wild_type_or_present	denotes	+
T40731	66390-66396	PR_EXT:000013059	denotes	PGC-1α
T40732	66396-66397	SO_EXT:sequence_nullness_or_absence	denotes	−
T40733	66398-66399	SO_EXT:sequence_nullness_or_absence	denotes	−
T40734	66400-66404	NCBITaxon:10088	denotes	mice
T40735	66436-66441	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	Fatty
T40736	66436-66446	CHEBI:35366	denotes	Fatty acid
T40737	66436-66456	GO:0019395	denotes	Fatty acid oxidation
T40738	66447-66456	MOP:0000568	denotes	oxidation
T40739	66461-66473	CHEBI:17855	denotes	triglyceride
T40740	66461-66483	GO:0019432	denotes	triglyceride synthesis
T40741	66527-66532	CL_GO_EXT:cell	denotes	cells
T40742	66546-66558	CHEBI:17855	denotes	Triglyceride
T40743	66546-66568	GO:0019432	denotes	Triglyceride synthesis
T40744	66623-66632	CHEBI:7896	denotes	Palmitate
T40745	66633-66642	MOP:0000568	denotes	oxidation
T40746	66677-66679	CHEBI:29238	denotes	3H
T40747	66681-66694	CHEBI:15756	denotes	palmitic acid
T40748	66737-66745	CL_GO_EXT:cell	denotes	cellular
T40749	66746-66753	CHEBI_PR_EXT:protein	denotes	protein
T40750	66767-66778	GO:0045333	denotes	respiration
T40751	66788-66793	CL_GO_EXT:cell	denotes	cells
T40752	66864-66870	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T40753	66909-66916	CHEBI:26605	denotes	saponin
T40754	66918-66929	GO:0045333	denotes	Respiration
T40755	66977-66986	CHEBI_EXT:succinate	denotes	succinate
T40756	67012-67020	CHEBI:28201	denotes	rotenone
T40757	67022-67033	GO:0045333	denotes	Respiration
T40758	67063-67065	CHEBI:15379	denotes	O2
T40759	67082-67089	CHEBI_PR_EXT:protein	denotes	protein
T42814	67108-67117	GO:0040011	denotes	locomotor
T42815	67128-67140	UBERON:0025534	denotes	sensorimotor
T42816	67159-67165	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T42817	67215-67221	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T42818	67227-67231	NCBITaxon:10088	denotes	mice
T42819	67310-67321	CHEBI_EXT:polystyrene	denotes	polystyrene
T42820	67939-67950	GO:0040011	denotes	ambulations
T42821	68141-68152	GO:0040011	denotes	ambulations
T42822	68211-68215	NCBITaxon:10088	denotes	mice
T42823	68348-68354	NCBITaxon:33208	denotes	animal
T42824	68395-68407	UBERON:0025534	denotes	sensorimotor
T42825	68557-68562	NCBITaxon:10088	denotes	mouse
T42826	68696-68702	NCBITaxon:33208	denotes	animal
T42827	68751-68755	UBERON:0000033	denotes	head
T42828	68909-68913	NCBITaxon:10088	denotes	mice
T42829	69017-69023	NCBITaxon:33208	denotes	animal
T42830	69062-69067	NCBITaxon:10088	denotes	mouse
T42831	69243-69248	NCBITaxon:10088	denotes	mouse
T42832	69418-69423	NCBITaxon:10088	denotes	mouse
T42833	69495-69504	CHEBI_EXT:poly_methyl_methacrylate	denotes	Plexiglas
T42834	69584-69589	NCBITaxon:10088	denotes	mouse
T42835	69633-69642	CHEBI_EXT:poly_methyl_methacrylate	denotes	Plexiglas
T42836	69753-69758	NCBITaxon:10088	denotes	mouse
T42837	69910-69915	NCBITaxon:10088	denotes	mouse
T42838	69952-69956	UBERON_EXT:paw	denotes	paws
T42839	70038-70044	PR_EXT:000013059	denotes	PGC-1α
T42840	70044-70045	SO_EXT:normal_or_wild_type_or_present	denotes	+
T42841	70046-70047	SO_EXT:normal_or_wild_type_or_present	denotes	+
T42842	70060-70066	PR_EXT:000013059	denotes	PGC-1α
T42843	70066-70067	SO_EXT:sequence_nullness_or_absence	denotes	−
T42844	70068-70069	SO_EXT:sequence_nullness_or_absence	denotes	−
T42845	70078-70082	NCBITaxon:10088	denotes	mice
T44012	70410-70414	NCBITaxon:10088	denotes	mice
T44013	70527-70533	CHEBI_EXT:oxygen	denotes	oxygen
T44014	70609-70616	NCBITaxon:33208	denotes	Animals
T44015	70638-70647	GO:0008152	denotes	metabolic
T44016	70704-70708	NCBITaxon:10088	denotes	Mice
T44017	70879-70886	NCBITaxon:33208	denotes	animals
T44018	70947-70953	CHEBI_EXT:oxygen	denotes	oxygen
T44019	71017-71022	NCBITaxon:10088	denotes	mouse
T44020	71126-71132	NCBITaxon:33208	denotes	animal
T44021	71135-71137	CHEBI:15379	denotes	O2
T44788	71179-71185	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T44789	71206-71213	NCBITaxon:33208	denotes	Animals
T44790	71219-71231	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T44791	71237-71245	CHEBI:6121	denotes	ketamine
T44792	71263-71276	UBERON:0001389	denotes	soleus muscle
T44793	71298-71301	UBERON:0000978	denotes	leg
T44794	71321-71327	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T44795	71353-71361	CHEBI:75958	denotes	solution
T44796	71379-71381	CHEBI:15379	denotes	O2
T44797	71389-71392	CHEBI:16526	denotes	CO2
T44798	71398-71404	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T44799	71415-71423	CHEBI:75958	denotes	solution
T44800	71448-71453	CHEBI:15377	denotes	water
T44801	71488-71494	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T44802	71605-71612	UBERON_EXT:muscle_structure_or_tissue	denotes	Muscles
T44803	71632-71640	GO:0006936	denotes	contract
T44804	71752-71758	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T44805	71903-71912	GO_EXT:biological_routing_or_transport	denotes	delivered
T45715	72730-72737	UBERON:0000948	denotes	cardiac
T45716	72857-72862	UBERON:0007023	denotes	adult
T45717	72863-72867	NCBITaxon:10088	denotes	mice
T45718	72884-72896	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T45719	72902-72914	UBERON:0001179	denotes	peritoneally
T45720	72925-72942	CHEBI:9561	denotes	thiopental sodium
T45721	72959-72963	NCBITaxon:10088	denotes	mice
T45722	73031-73045	UBERON:0005396	denotes	carotid artery
T45723	73080-73087	UBERON:0003126	denotes	trachea
T45724	73240-73254	UBERON:0002084	denotes	left ventricle
T45725	73277-73289	UBERON:0002137	denotes	aortic valve
T45726	73406-73416	CHEBI:4670	denotes	dobutamine
T45727	73418-73420	_FRAGMENT	denotes	β1
T45728	73432-73443	GO_PR_EXT:beta1_adrenergic_receptor	denotes	-adrenergic
T45729	73422-73424	_FRAGMENT	denotes	β2
T45730	73432-73443	GO_PR_EXT:beta2_adrenergic_receptor	denotes	-adrenergic
T45731	73430-73443	GO_PR_EXT:alpha1_adrenergic_receptor	denotes	α1-adrenergic
T45732	73433-73451	CHEBI_EXT:37886	denotes	adrenergic agonist
T45733	73444-73451	CHEBI_GO_EXT:agonist	denotes	agonist
T46717	73678-73683	NCBITaxon:10088	denotes	mouse
T46718	73684-73689	UBERON:0000948	denotes	heart
T46719	73717-73722	NCBITaxon:10088	denotes	mouse
T46720	73723-73728	UBERON:0000948	denotes	heart
T46721	73791-73796	UBERON:0007023	denotes	Adult
T46722	73797-73801	NCBITaxon:10088	denotes	mice
T46723	73863-73873	CHEBI_EXT:anaesthetic_process_or_quality	denotes	anesthesia
T46724	73875-73882	NCBITaxon:33208	denotes	Animals
T46725	73900-73912	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T46726	73929-73949	CHEBI:7984	denotes	sodium pentobarbital
T46727	73954-73960	UBERON:0000948	denotes	Hearts
T46728	74016-74027	CHEBI:17544	denotes	bicarbonate
T46729	74034-74042	CHEBI:75958	denotes	solution
T46730	74051-74055	CHEBI:26710	denotes	NaCl
T46731	74063-74069	CHEBI:32139	denotes	NaHCO3
T46732	74078-74081	CHEBI:32588	denotes	KCl
T46733	74090-74096	CHEBI:63036	denotes	KH2PO4
T46734	74105-74110	CHEBI:3312	denotes	CaCl2
T46735	74119-74126	CHEBI:17234	denotes	glucose
T46736	74144-74151	PR_EXT:000045358	denotes	insulin
T46737	74163-74169	UBERON:0000948	denotes	Hearts
T46738	74200-74205	UBERON:0000947	denotes	aorta
T46739	74269-74280	UBERON:0002079	denotes	left atrial
T46740	74346-74354	CHEBI:75958	denotes	solution
T46741	74373-74382	CHEBI:7896	denotes	palmitate
T46742	74383-74388	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bound
T46743	74395-74405	CHEBI:35366	denotes	fatty acid
T46744	74450-74452	CHEBI_EXT:mercury	denotes	Hg
T46745	74488-74490	CHEBI_EXT:mercury	denotes	Hg
T46746	74518-74524	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T46747	74525-74533	CHEBI:75958	denotes	solution
T46748	74567-74574	UBERON:0000948	denotes	cardiac
T46749	74583-74589	UBERON:0000947	denotes	aortic
T46750	74625-74630	UBERON:0000948	denotes	heart
T46751	74909-74916	UBERON:0000948	denotes	Cardiac
T46752	74982-74989	UBERON:0000948	denotes	cardiac
T47479	75087-75099	UBERON:0025534	denotes	sensorimotor
T47480	75271-75283	UBERON:0025534	denotes	sensorimotor
T47481	75329-75337	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T38928	64121-64128	PR_EXT:000045358	denotes	Insulin
T38929	64133-64140	CHEBI:17234	denotes	glucose
T38930	64157-64164	CHEBI:17234	denotes	Glucose
T39311	64685-64691	CHEBI_EXT:oxygen	denotes	Oxygen
T39312	64728-64734	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T39313	64735-64739	NCBITaxon:10088	denotes	mice
T39314	64815-64821	CHEBI_EXT:oxygen	denotes	oxygen
T39315	64878-64891	GO_PR_EXT:beta3_adrenergic_receptor	denotes	β3-adrenergic
T39316	64956-64962	CHEBI_EXT:saline_solution	denotes	saline
T39317	65013-65020	CHEBI_GO_EXT:agonist	denotes	agonist
T39318	65035-65041	CHEBI_EXT:oxygen	denotes	oxygen
T45211	72363-72368	UBERON:0007023	denotes	Adult
T45212	72369-72375	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T45213	72376-72380	NCBITaxon:10088	denotes	mice
T45214	72586-72591	NCBITaxon:10088	denotes	mouse
T22438	38549-38556	CHEBI:17234	denotes	glucose
T5653	7860-7867	GO:0005634	denotes	nuclear
T30411	56685-56700	GO_EXT:transcription	denotes	transcriptional
T30412	56685-56713	GO_EXT:0003713	denotes	transcriptional coactivators
T30413	56722-56728	PR_EXT:000013059	denotes	PGC-1α
T30414	56744-56752	CL_GO_EXT:cell	denotes	cellular
T30415	56774-56785	GO_PATO_EXT:physiological_process_or_quality	denotes	physiologic
T30416	56816-56831	GO_EXT:transcription	denotes	transcriptional
T30417	56832-56842	_FRAGMENT	denotes	control of
T30418	56850-56860	GO:0019222	denotes	metabolism
T30419	56879-56897	GO:0050794	denotes	cellular processes
T30420	56879-56887	CL_GO_EXT:cell	denotes	cellular
T30421	56941-56947	PR_EXT:000013059	denotes	PGC-1α
T30422	56960-56975	GO_EXT:transcription	denotes	transcriptional
T30423	57024-57033	GO:0008152	denotes	metabolic
T30424	57056-57065	GO:0008152	denotes	metabolic
T30425	57066-57076	GO_PATO_EXT:biological_maturation	denotes	maturation
T30426	57085-57090	GO:0007567	denotes	natal
T30427	57091-57097	GO_EXT:biological_growth_entity_or_process	denotes	growth
T30428	57116-57122	PR_EXT:000013059	denotes	PGC-1α
T30429	57123-57127	SO_EXT:sequence_nullness	denotes	null
T30430	57128-57132	NCBITaxon:10088	denotes	mice
T30431	57264-57270	PR_EXT:000013059	denotes	PGC-1α
T30432	57332-57338	PR_EXT:000013059	denotes	PGC-1α
T30433	57338-57339	SO_EXT:sequence_nullness_or_absence	denotes	−
T30434	57340-57341	SO_EXT:sequence_nullness_or_absence	denotes	−
T30435	57342-57346	NCBITaxon:10088	denotes	mice
T30436	57372-57378	NCBITaxon:39107	denotes	murine
T30437	57427-57437	GO:0008152	denotes	metabolism
T30438	57460-57467	UBERON:0002107	denotes	hepatic
T30439	57499-57504	UBERON:0000948	denotes	heart
T30440	57506-57521	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T30441	57527-57549	UBERON:0001017	denotes	central nervous system
R4008	T17359	T17358	_lexicallyChainedTo	stimulus,to
R5709	T24044	T24043	_lexicallyChainedTo	cell neurons,Purkinje
R6083	T30050	T30049	_lexicallyChainedTo	metabolism,control of
R6087	T29949	T29948	_lexicallyChainedTo	metabolism,cellular
R6088	T30219	T30218	_lexicallyChainedTo	cerebral cortex,neurons of
R6089	T30388	T30387	_lexicallyChainedTo	border,exon
R6090	T30248	T30247	_lexicallyChainedTo	nervous system,peripheral
R6091	T30280	T30279	_lexicallyChainedTo	δ,CCAAT-enhancer-binding protein
R6092	T30418	T30417	_lexicallyChainedTo	metabolism,control of
R6093	T30419	T30417	_lexicallyChainedTo	cellular processes,control of
R8686	T34046	T34045	_lexicallyChainedTo	primers,5′
R9987	T38939	T38938	_lexicallyChainedTo	insulin,human
R10199	T40024	T40023	_lexicallyChainedTo	muscle,Cardiac
R11637	T45728	T45727	_lexicallyChainedTo	-adrenergic,β1
R11638	T45730	T45729	_lexicallyChainedTo	-adrenergic,β2
R2	T722	T721	_lexicallyChainedTo	stressors,adaptation to
R310	T3305	T3304	_lexicallyChainedTo	pathways,signaling
R315	T3312	T3311	_lexicallyChainedTo	genes,nuclear
R317	T3321	T3320	_lexicallyChainedTo	coactivator-1α,peroxisome proliferator-activated receptor-γ
R318	T3321	T3323	_lexicallyChainedTo	coactivator-1α,PPARγ
R319	T3329	T3328	_lexicallyChainedTo	metabolism,control of cellular
R320	T3353	T3352	_lexicallyChainedTo	metabolism,cellular
R321	T3361	T3360	_lexicallyChainedTo	production,ATP
R322	T3378	T3377	_lexicallyChainedTo	metabolism,control of
R323	T3422	T3421	_lexicallyChainedTo	replication,mitochondrial DNA
R325	T3441	T3440	_lexicallyChainedTo	muscle fibers,formation of
R326	T3444	T3443	_lexicallyChainedTo	muscle fibers,type I
R327	T3447	T3446	_lexicallyChainedTo	muscle fibers,oxidative
R328	T3449	T3448	_lexicallyChainedTo	muscle fibers,slow-twitch
R329	T3457	T3456	_lexicallyChainedTo	metabolism,control of
R1113	T5607	T5606	_lexicallyChainedTo	transcript,region of
R1114	T5611	T5610	_lexicallyChainedTo	border,exon
R1115	T5617	T5616	_lexicallyChainedTo	border,exon
R1116	T5637	T5636	_lexicallyChainedTo	border,exon
R3374	T15136	T15135	_lexicallyChainedTo	-adrenergic,β1
R4007	T17358	T17357	_lexicallyChainedTo	to,response

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T578	0-6	PR:000013059	denotes	PGC-1α
T579	31-37	UBERON:0000467	denotes	System
T580	45-54	GO:0008152	denotes	Metabolic
T581	105-112	GO:0065007	denotes	Control
T582	117-124	UBERON:0002107	denotes	Hepatic
T583	193-197	SO:0000704	denotes	gene
T584	239-249	GO:0005777	denotes	peroxisome
T585	239-298	PR:000013059	denotes	peroxisome proliferator-activated receptor-γ coactivator-1α
T586	300-306	PR:000013059	denotes	PGC-1α
T587	324-328	NCBITaxon:10088	denotes	mice
T588	330-336	PR:000013059	denotes	PGC-1α
T589	343-349	PR:000013059	denotes	PGC-1α
T590	354-358	NCBITaxon:10088	denotes	mice
T591	418-424	UBERON:0000467	denotes	system
T592	472-481	GO:0008152	denotes	metabolic
T593	501-506	GO:0007567	denotes	natal
T594	517-522	UBERON:0000948	denotes	heart
T595	527-554	UBERON:0006907	denotes	slow-twitch skeletal muscle
T596	556-562	UBERON:0000062	denotes	organs
T597	573-586	GO:0005739	denotes	mitochondrial
T598	617-623	PR:000013059	denotes	PGC-1α
T599	627-631	NCBITaxon:10088	denotes	mice
T600	647-653	PR:000013059	denotes	PGC-1α
T601	657-661	NCBITaxon:10088	denotes	mice
T602	745-758	GO:0005739	denotes	Mitochondrial
T603	770-781	GO:0045333	denotes	respiratory
T604	808-835	UBERON:0006907	denotes	slow-twitch skeletal muscle
T605	839-845	PR:000013059	denotes	PGC-1α
T606	849-853	NCBITaxon:10088	denotes	mice
T607	916-922	PR:000013059	denotes	PGC-1α
T608	926-930	NCBITaxon:10088	denotes	mice
T609	962-969	UBERON:0000948	denotes	cardiac
T610	1007-1028	GO:0002027	denotes	control of heart rate
T611	1018-1023	UBERON:0000948	denotes	heart
T612	1034-1040	PR:000013059	denotes	PGC-1α
T613	1044-1048	NCBITaxon:10088	denotes	mice
T614	1150-1161	GO:0031649	denotes	thermogenic
T615	1205-1211	PR:000013059	denotes	PGC-1α
T616	1215-1219	NCBITaxon:10088	denotes	mice
T617	1228-1235	UBERON:0002107	denotes	hepatic
T618	1278-1291	GO:0005739	denotes	mitochondrial
T619	1292-1303	GO:0045333	denotes	respiratory
T620	1330-1340	GO:0010467	denotes	expression
T621	1344-1353	GO:0008610	denotes	lipogenic
T622	1354-1359	SO:0000704	denotes	genes
T623	1375-1381	PR:000013059	denotes	PGC-1α
T624	1385-1389	NCBITaxon:10088	denotes	mice
T625	1428-1435	PR:000045358	denotes	insulin
T626	1480-1488	GO:0005773	denotes	vacuolar
T627	1518-1540	UBERON:0001017	denotes	central nervous system
T628	1544-1550	PR:000013059	denotes	PGC-1α
T629	1554-1558	NCBITaxon:10088	denotes	mice
T630	1591-1597	PR:000013059	denotes	PGC-1α
T631	1627-1640	_FRAGMENT	denotes	adaptation to
T632	1671-1680	GO:0051866	denotes	stressors
T633	1645-1654	GO:0008152	denotes	metabolic
T634	1688-1693	GO:0007567	denotes	natal
T635	1694-1698	UBERON:0000104	denotes	life
T3145	1910-1923	GO:0005739	denotes	Mitochondrial
T3146	1959-1968	GO:0065007	denotes	regulated
T3147	2019-2037	NCBITaxon:40674	denotes	mammalian organism
T3148	2048-2053	GO:0007567	denotes	birth
T3149	2059-2064	GO:0007567	denotes	natal
T3150	2065-2078	GO:0005739	denotes	mitochondrial
T3151	2138-2148	GO:0065007	denotes	regulatory
T3152	2163-2170	GO:0065007	denotes	control
T3153	2186-2196	GO:0010467	denotes	expression
T3154	2200-2207	GO:0005634	denotes	nuclear
T3155	2200-2207	_FRAGMENT	denotes	nuclear
T3156	2226-2231	SO:0000087	denotes	genes
T3157	2212-2225	GO:0005739	denotes	mitochondrial
T3158	2212-2231	SO:0000088	denotes	mitochondrial genes
T3159	2244-2257	GO:0005739	denotes	mitochondrial
T3160	2269-2279	GO:0008152	denotes	metabolism
T3161	2365-2375	GO:0005777	denotes	peroxisome
T3162	2365-2409	_FRAGMENT	denotes	peroxisome proliferator-activated receptor-γ
T3163	2418-2432	PR:000013059	denotes	coactivator-1α
T3164	2411-2416	_FRAGMENT	denotes	PPARγ
T3165	2434-2440	PR:000013059	denotes	PGC-1α
T3166	2477-2487	GO:0065007	denotes	regulatory
T3167	2530-2549	_FRAGMENT	denotes	control of cellular
T3168	2557-2567	GO:0031323	denotes	metabolism
T3169	2579-2592	GO:0005739	denotes	mitochondrial
T3170	2624-2630	PR:000013059	denotes	PGC-1α
T3171	2679-2692	UBERON:0001348	denotes	brown adipose
T3172	2733-2743	GO:0060612	denotes	adipogenic
T3173	2744-2751	GO:0005634	denotes	nuclear
T3174	2761-2766	PR:000013058	denotes	PPARγ
T3175	2839-2864	PR:000013159	denotes	PGC-1 related coactivator
T3176	2866-2869	PR:000013159	denotes	PRC
T3177	2879-2885	PR:000013060	denotes	PGC-1β
T3178	2893-2899	PR:000013059	denotes	PGC-1α
T3179	2950-2957	GO:0005634	denotes	nuclear
T3180	2965-2972	GO:0005634	denotes	nuclear
T3181	3016-3024	_FRAGMENT	denotes	cellular
T3182	3032-3042	GO:0044237	denotes	metabolism
T3183	3048-3054	PR:000013059	denotes	PGC-1α
T3184	3113-3119	UBERON:0000479	denotes	tissue
T3185	3129-3139	GO:0010467	denotes	expression
T3186	3231-3244	GO:0005739	denotes	mitochondrial
T3187	3245-3248	_FRAGMENT	denotes	ATP
T3188	3257-3267	GO:0006754	denotes	production
T3189	3252-3267	GO:0031649	denotes	heat production
T3190	3277-3283	PR:000013059	denotes	PGC-1α
T3191	3299-3319	UBERON:0001348	denotes	brown adipose tissue
T3192	3321-3324	UBERON:0001348	denotes	BAT
T3193	3327-3332	UBERON:0000948	denotes	heart
T3194	3334-3361	UBERON:0006907	denotes	slow-twitch skeletal muscle
T3195	3367-3373	UBERON:0002113	denotes	kidney
T3196	3378-3385	UBERON:0000479	denotes	tissues
T3197	3405-3418	GO:0005739	denotes	mitochondrial
T3198	3432-3442	GO:0010467	denotes	expression
T3199	3450-3454	SO:0000704	denotes	gene
T3200	3464-3470	PR:000013059	denotes	PGC-1α
T3201	3607-3613	PR:000013059	denotes	PGC-1α
T3202	3645-3655	_FRAGMENT	denotes	control of
T3203	3663-3673	GO:0019222	denotes	metabolism
T3204	3730-3740	GO:0010467	denotes	expression
T3205	3764-3770	PR:000013059	denotes	PGC-1α
T3206	3796-3809	GO:0005739	denotes	mitochondrial
T3207	3825-3833	GO:0065007	denotes	regulate
T3208	3834-3847	GO:0005739	denotes	mitochondrial
T3209	3848-3859	GO:0045333	denotes	respiratory
T3210	3877-3883	PR:000013059	denotes	PGC-1α
T3211	3915-3928	GO:0005739	denotes	mitochondrial
T3212	3915-3949	PR:000017035	denotes	mitochondrial uncoupling protein-1
T3213	3951-3956	PR:000017035	denotes	UCP-1
T3214	3961-3964	UBERON:0001348	denotes	BAT
T3215	3995-4002	GO:0005634	denotes	nuclear
T3216	4021-4026	PR:000013058	denotes	PPARγ
T3217	4031-4038	UBERON:0002046	denotes	thyroid
T3218	4068-4078	GO:0010467	denotes	expression
T3219	4090-4100	GO:0060612	denotes	adipogenic
T3220	4114-4123	NCBITaxon:40674	denotes	mammalian
T3221	4153-4159	PR:000013059	denotes	PGC-1α
T3222	4170-4183	GO:0005739	denotes	mitochondrial
T3223	4253-4260	GO:0005634	denotes	nuclear
T3224	4253-4282	PR:000011422	denotes	nuclear respiratory factors 1
T3225	4261-4272	GO:0045333	denotes	respiratory
T3226	4290-4295	PR:000011422	denotes	NRF-1
T3227	4308-4321	GO:0005739	denotes	mitochondrial
T3228	4308-4344	PR:000016262	denotes	mitochondrial transcription factor A
T3229	4346-4350	PR:000016262	denotes	Tfam
T3230	4387-4400	GO:0005739	denotes	mitochondrial
T3231	4387-4404	_FRAGMENT	denotes	mitochondrial DNA
T3232	4423-4434	GO:0006264	denotes	replication
T3233	4466-4473	UBERON:0000948	denotes	cardiac
T3234	4466-4482	CL:0000746	denotes	cardiac myocytes
T3235	4505-4511	UBERON:0000948	denotes	hearts
T3236	4526-4530	NCBITaxon:10088	denotes	mice
T3237	4558-4568	GO:0010467	denotes	expression
T3238	4572-4578	PR:000013059	denotes	PGC-1α
T3239	4588-4601	GO:0005739	denotes	mitochondrial
T3240	4637-4647	GO:0010467	denotes	expression
T3241	4651-4657	PR:000013059	denotes	PGC-1α
T3242	4661-4669	UBERON:0004288	denotes	skeletal
T3243	4691-4695	NCBITaxon:10088	denotes	mice
T3244	4705-4718	GO:0005739	denotes	mitochondrial
T3245	4741-4753	_FRAGMENT	denotes	formation of
T3246	4807-4820	GO:0048747	denotes	muscle fibers
T3247	4754-4767	GO:0005739	denotes	mitochondrial
T3248	4773-4779	_FRAGMENT	denotes	type I
T3249	4807-4820	CL:0002211	denotes	muscle fibers
T3250	4781-4790	MOP:0000568	denotes	oxidative
T3251	4781-4790	_FRAGMENT	denotes	oxidative
T3252	4807-4820	CL:0002210	denotes	muscle fibers
T3253	4793-4804	_FRAGMENT	denotes	slow-twitch
T3254	4807-4820	CL:0000189	denotes	muscle fibers
T3255	4869-4875	PR:000013059	denotes	PGC-1α
T3256	4899-4912	GO:0005739	denotes	mitochondrial
T3257	4957-4963	PR:000013059	denotes	PGC-1α
T3258	4971-4990	GO:0042592	denotes	homeostatic control
T3259	4983-4993	_FRAGMENT	denotes	control of
T3260	5010-5020	GO:0019222	denotes	metabolism
T3261	5022-5028	PR:000013059	denotes	PGC-1α
T3262	5047-5055	GO:0065007	denotes	regulate
T3263	5068-5075	UBERON:0002107	denotes	hepatic
T3264	5076-5089	GO:0006094	denotes	gluconeogenic
T3265	5090-5095	SO:0000704	denotes	genes
T3266	5150-5160	GO:0010467	denotes	expression
T3267	5164-5170	PR:000013059	denotes	PGC-1α
T3268	5186-5199	GO:0005739	denotes	mitochondrial
T3269	5219-5227	UBERON:0004288	denotes	skeletal
T3270	5238-5244	NCBITaxon:9606	denotes	humans
T3271	5250-5257	PR:000045358	denotes	insulin
T3272	5307-5338	SO:0000694	denotes	single nucleotide polymorphisms
T3273	5350-5355	NCBITaxon:9606	denotes	human
T3274	5356-5362	PR:000013059	denotes	PGC-1α
T3275	5363-5367	SO:0000704	denotes	gene
T3276	5543-5549	PR:000013059	denotes	PGC-1α
T3277	5564-5574	GO:0065007	denotes	regulating
T3278	5579-5584	GO:0007567	denotes	natal
T3279	5592-5602	GO:0008152	denotes	metabolism
T3280	5630-5636	PR:000013059	denotes	PGC-1α
T3281	5648-5657	GO:0008152	denotes	metabolic
T3282	5658-5669	GO:0042592	denotes	homeostasis
T3283	5671-5684	GO:0005739	denotes	mitochondrial
T3284	5829-5833	NCBITaxon:10088	denotes	mice
T3285	5864-5870	PR:000013059	denotes	PGC-1α
T3286	5871-5875	SO:0000704	denotes	gene
T3287	5892-5898	PR:000013059	denotes	PGC-1α
T3288	5902-5906	NCBITaxon:10088	denotes	mice
T3289	5924-5930	PR:000013059	denotes	PGC-1α
T3290	5965-5970	GO:0007567	denotes	natal
T3291	5991-6004	GO:0005739	denotes	mitochondrial
T3292	6069-6075	PR:000013059	denotes	PGC-1α
T3293	6113-6122	GO:0008152	denotes	metabolic
T3294	6144-6150	UBERON:0000062	denotes	organs
T3295	6171-6203	GO:0051866	denotes	adaptation to physiologic stress
T3296	6215-6220	GO:0007567	denotes	natal
T5501	6255-6261	PR:000013059	denotes	PGC-1α
T5502	6262-6266	SO:0000704	denotes	Gene
T5503	6270-6274	NCBITaxon:10088	denotes	Mice
T5504	6292-6296	SO:0000704	denotes	gene
T5505	6297-6313	SO:0001644	denotes	targeting vector
T5506	6338-6343	SO:0000147	denotes	exons
T5507	6359-6365	NCBITaxon:39107	denotes	murine
T5508	6366-6372	PR:000013059	denotes	PGC-1α
T5509	6373-6377	SO:0000704	denotes	gene
T5510	6616-6620	SO:0000147	denotes	exon
T5511	6643-6648	SO:0000147	denotes	exons
T5512	6789-6795	SO:0001023	denotes	allele
T5513	6878-6884	PR:000013059	denotes	PGC-1α
T5514	6885-6889	SO:0000704	denotes	gene
T5515	6925-6935	SO:0000673	denotes	transcript
T5516	6987-6992	UBERON:0000948	denotes	heart
T5517	7003-7010	UBERON:0000479	denotes	tissues
T5518	7014-7020	PR:000013059	denotes	PGC-1α
T5519	7024-7028	NCBITaxon:10088	denotes	mice
T5520	7136-7140	SO:0000704	denotes	gene
T5521	7175-7182	SO:0000112	denotes	primers
T5522	7210-7219	_FRAGMENT	denotes	region of
T5523	7236-7246	SO:0000833	denotes	transcript
T5524	7224-7230	PR:000013059	denotes	PGC-1α
T5525	7231-7235	SO:0000704	denotes	gene
T5526	7262-7266	_FRAGMENT	denotes	exon
T5527	7271-7277	SO:0000333	denotes	border
T5528	7305-7311	PR:000013059	denotes	PGC-1α
T5529	7315-7319	NCBITaxon:10088	denotes	mice
T5530	7328-7332	_FRAGMENT	denotes	exon
T5531	7337-7343	SO:0000333	denotes	border
T5532	7381-7387	PR:000013059	denotes	PGC-1α
T5533	7391-7395	NCBITaxon:10088	denotes	mice
T5534	7402-7406	SO:0000147	denotes	exon
T5535	7436-7441	UBERON:0000948	denotes	heart
T5536	7446-7449	UBERON:0001348	denotes	BAT
T5537	7476-7482	PR:000013059	denotes	PGC-1α
T5538	7486-7490	NCBITaxon:10088	denotes	mice
T5539	7520-7524	SO:0000147	denotes	exon
T5540	7557-7563	PR:000013059	denotes	PGC-1α
T5541	7567-7571	NCBITaxon:10088	denotes	mice
T5542	7588-7592	_FRAGMENT	denotes	exon
T5543	7599-7605	SO:0000333	denotes	border
T5544	7682-7688	PR:000013059	denotes	PGC-1α
T5545	7692-7696	NCBITaxon:10088	denotes	mice
T5546	7732-7738	PR:000013059	denotes	PGC-1α
T5547	7742-7746	NCBITaxon:10088	denotes	mice
T5548	7775-7785	SO:0000673	denotes	transcript
T5549	7799-7805	PR:000013059	denotes	PGC-1α
T5550	7860-7867	GO:0005634	denotes	nuclear
T5551	7918-7921	UBERON:0001348	denotes	BAT
T5552	7925-7931	PR:000013059	denotes	PGC-1α
T5553	7935-7939	NCBITaxon:10088	denotes	mice
T5554	8037-8047	GO:0010467	denotes	expression
T5555	8051-8057	PR:000013059	denotes	PGC-1α
T5556	8061-8064	UBERON:0001348	denotes	BAT
T5557	8081-8087	PR:000013059	denotes	PGC-1α
T5558	8173-8183	GO:0010467	denotes	expression
T5559	8191-8196	SO:0000704	denotes	genes
T5560	8244-8250	PR:000013060	denotes	PGC-1β
T5561	8255-8258	PR:000013159	denotes	PRC
T5562	8293-8298	UBERON:0000948	denotes	heart
T5563	8302-8308	PR:000013059	denotes	PGC-1α
T5564	8312-8316	NCBITaxon:10088	denotes	mice
T5565	8392-8396	SO:0000704	denotes	gene
T5566	8427-8433	PR:000013059	denotes	PGC-1α
T5567	8439-8445	SO:0001023	denotes	allele
T7513	10908-10914	PR:000013059	denotes	PGC-1α
T7514	10918-10922	NCBITaxon:10088	denotes	Mice
T7515	10969-10975	PR:000013059	denotes	PGC-1α
T7516	10980-10984	NCBITaxon:10088	denotes	mice
T7517	11007-11013	PR:000013059	denotes	PGC-1α
T7518	11156-11162	GO:0016265	denotes	deaths
T7519	11203-11209	PR:000013059	denotes	PGC-1α
T7520	11217-11223	PR:000013059	denotes	PGC-1α
T7521	11293-11298	GO:0007567	denotes	birth
T7522	11367-11373	PR:000013059	denotes	PGC-1α
T7523	11377-11381	NCBITaxon:10088	denotes	mice
T7524	11406-11412	PR:000013059	denotes	PGC-1α
T7525	11469-11475	PR:000013059	denotes	PGC-1α
T7526	11483-11489	PR:000013059	denotes	PGC-1α
T7527	11632-11638	PR:000013059	denotes	PGC-1α
T7528	11642-11646	NCBITaxon:10088	denotes	mice
T7529	11671-11677	PR:000013059	denotes	PGC-1α
T7530	11758-11764	PR:000013059	denotes	PGC-1α
T7531	11768-11772	NCBITaxon:10088	denotes	mice
T7532	11830-11836	PR:000013059	denotes	PGC-1α
T7533	11840-11844	NCBITaxon:10088	denotes	mice
T7534	11884-11888	CHEBI:33290	denotes	food
T7535	11884-11895	GO:0007631	denotes	food intake
T7536	12097-12103	PR:000013059	denotes	PGC-1α
T7537	12107-12111	NCBITaxon:10088	denotes	mice
T7538	12143-12149	PR:000013059	denotes	PGC-1α
T7539	12409-12415	PR:000013059	denotes	PGC-1α
T7540	12419-12423	NCBITaxon:10088	denotes	mice
T7541	12465-12469	NCBITaxon:10088	denotes	mice
T7542	13597-13602	UBERON:0000062	denotes	organ
T7543	13650-13663	GO:0005739	denotes	mitochondrial
T7544	13671-13681	GO:0008152	denotes	metabolism
T7545	13690-13695	GO:0007567	denotes	natal
T7546	13714-13720	UBERON:0000062	denotes	organs
T7547	13737-13742	UBERON:0000948	denotes	heart
T7548	13774-13782	UBERON:0004288	denotes	skeletal
T7549	13802-13815	UBERON:0001388	denotes	gastrocnemius
T7550	13820-13826	UBERON:0001389	denotes	soleus
T7551	13845-13854	MOP:0000568	denotes	oxidative
T7552	13855-13872	UBERON:0001385	denotes	tibialis anterior
T7553	13918-13924	PR:000013059	denotes	PGC-1α
T7554	13928-13932	NCBITaxon:10088	denotes	mice
T7555	13967-13973	PR:000013059	denotes	PGC-1α
T7556	14069-14074	UBERON:0000955	denotes	brain
T7557	14076-14081	UBERON:0002107	denotes	liver
T7558	14083-14089	UBERON:0002113	denotes	kidney
T7559	14095-14098	UBERON:0001348	denotes	BAT
T7560	14204-14211	UBERON:0000479	denotes	tissues
T7561	14222-14235	GO:0005739	denotes	mitochondrial
T7562	14265-14270	UBERON:0000948	denotes	heart
T7563	14275-14302	UBERON:0006907	denotes	slow-twitch skeletal muscle
T7564	14337-14343	PR:000013059	denotes	PGC-1α
T7565	14347-14351	NCBITaxon:10088	denotes	mice
T9611	14370-14383	GO:0005739	denotes	Mitochondrial
T9612	14397-14403	PR:000013059	denotes	PGC-1α
T9613	14407-14411	NCBITaxon:10088	denotes	Mice
T9614	14512-14517	GO:0007567	denotes	natal
T9615	14518-14523	UBERON:0000948	denotes	heart
T9616	14528-14536	UBERON:0004288	denotes	skeletal
T9617	14551-14557	PR:000013059	denotes	PGC-1α
T9618	14561-14565	NCBITaxon:10088	denotes	mice
T9619	14633-14653	GO:0031012	denotes	extracellular matrix
T9620	14661-14668	UBERON:0000479	denotes	tissues
T9621	14683-14689	PR:000013059	denotes	PGC-1α
T9622	14693-14697	NCBITaxon:10088	denotes	mice
T9623	14746-14752	PR:000013059	denotes	PGC-1α
T9624	14756-14769	GO:0005739	denotes	mitochondrial
T9625	14807-14820	GO:0005739	denotes	mitochondrial
T9626	14852-14859	UBERON:0000479	denotes	tissues
T9627	14861-14869	CHEBI:10545	denotes	Electron
T9628	14918-14930	GO:0005739	denotes	mitochondria
T9629	14934-14947	UBERON:0001389	denotes	soleus muscle
T9630	14951-14957	PR:000013059	denotes	PGC-1α
T9631	14961-14965	NCBITaxon:10088	denotes	mice
T9632	15000-15006	PR:000013059	denotes	PGC-1α
T9633	15064-15072	CHEBI:10545	denotes	electron
T9634	15131-15137	UBERON:0001389	denotes	soleus
T9635	15138-15150	GO:0005739	denotes	mitochondria
T9636	15178-15184	PR:000013059	denotes	PGC-1α
T9637	15188-15192	NCBITaxon:10088	denotes	mice
T9638	15205-15211	PR:000013059	denotes	PGC-1α
T9639	15254-15266	GO:0030016	denotes	myofibrillar
T9640	15318-15331	GO:0005739	denotes	mitochondrial
T9641	15372-15382	GO:0010467	denotes	expression
T9642	15386-15393	GO:0005634	denotes	nuclear
T9643	15386-15399	SO:0000087	denotes	nuclear genes
T9644	15430-15443	GO:0005739	denotes	mitochondrial
T9645	15444-15452	CHEBI:10545	denotes	electron
T9646	15444-15462	MOP:0000615	denotes	electron transport
T9647	15464-15476	PR:000002199	denotes	cytochrome c
T9648	15464-15476	CHEBI:18070	denotes	cytochrome c
T9649	15481-15491	CHEBI:4056	denotes	cytochrome
T9650	15508-15517	MOP:0000568	denotes	oxidative
T9651	15508-15533	GO:0006119	denotes	oxidative phosphorylation
T9652	15535-15563	PR:000004454	denotes	beta subunit of ATP synthase
T9653	15568-15581	UBERON:0001389	denotes	soleus muscle
T9654	15585-15591	PR:000013059	denotes	PGC-1α
T9655	15595-15599	NCBITaxon:10088	denotes	mice
T9656	15614-15620	PR:000013059	denotes	PGC-1α
T9657	15651-15661	GO:0010467	denotes	expression
T9658	15665-15669	PR:000016262	denotes	Tfam
T9659	15679-15685	PR:000013059	denotes	PGC-1α
T9660	15705-15718	GO:0005739	denotes	mitochondrial
T9661	15705-15734	GO:0006264	denotes	mitochondrial DNA replication
T9662	15768-15774	PR:000013059	denotes	PGC-1α
T9663	15778-15784	UBERON:0001389	denotes	soleus
T9664	15834-15847	GO:0005739	denotes	mitochondrial
T9665	15904-15910	UBERON:0001389	denotes	soleus
T9666	15942-15955	GO:0005739	denotes	mitochondrial
T9667	16003-16008	UBERON:0000948	denotes	heart
T9668	16012-16015	UBERON:0001348	denotes	BAT
T9669	16019-16025	PR:000013059	denotes	PGC-1α
T9670	16029-16033	NCBITaxon:10088	denotes	mice
T9671	17520-17533	GO:0005739	denotes	mitochondrial
T9672	17562-17570	UBERON:0004288	denotes	skeletal
T9673	17581-17587	PR:000013059	denotes	PGC-1α
T9674	17591-17595	NCBITaxon:10088	denotes	mice
T9675	17597-17610	GO:0005739	denotes	mitochondrial
T9676	17611-17622	GO:0045333	denotes	respiration
T9677	17649-17655	UBERON:0000479	denotes	tissue
T9678	17677-17690	UBERON:0001389	denotes	soleus muscle
T9679	17695-17701	UBERON:0001389	denotes	soleus
T9680	17705-17711	PR:000013059	denotes	PGC-1α
T9681	17715-17719	NCBITaxon:10088	denotes	mice
T9682	17770-17781	GO:0045333	denotes	respiration
T9683	17875-17886	GO:0045333	denotes	respiration
T9684	17913-17923	CHEBI:25675	denotes	oligomycin
T9685	17998-18009	GO:0045333	denotes	respiration
T9686	18013-18027	GO:0006754	denotes	ATP production
T9687	18061-18067	PR:000013059	denotes	PGC-1α
T9688	18071-18075	NCBITaxon:10088	denotes	mice
T9689	18151-18164	GO:0005739	denotes	mitochondrial
T12298	18190-18198	UBERON:0004288	denotes	Skeletal
T12299	18218-18224	PR:000013059	denotes	PGC-1α
T12300	18228-18232	NCBITaxon:10088	denotes	Mice
T12301	18252-18265	GO:0005739	denotes	mitochondrial
T12302	18277-18288	GO:0045333	denotes	respiratory
T12303	18301-18309	UBERON:0004288	denotes	skeletal
T12304	18348-18356	UBERON:0004288	denotes	skeletal
T12305	18407-18416	GO:0040011	denotes	locomotor
T12306	18493-18499	PR:000013059	denotes	PGC-1α
T12307	18508-18512	NCBITaxon:10088	denotes	mice
T12308	18560-18571	GO:0040011	denotes	ambulations
T12309	18617-18623	PR:000013059	denotes	PGC-1α
T12310	18721-18727	PR:000013059	denotes	PGC-1α
T12311	18731-18735	NCBITaxon:10088	denotes	mice
T12312	18824-18830	PR:000013059	denotes	PGC-1α
T12313	18834-18838	NCBITaxon:10088	denotes	mice
T12314	19233-19239	PR:000013059	denotes	PGC-1α
T12315	19243-19247	NCBITaxon:10088	denotes	mice
T12316	19323-19334	GO:0001966	denotes	thigmotaxis
T12317	20898-20910	UBERON:0025534	denotes	sensorimotor
T12318	20928-20934	PR:000013059	denotes	PGC-1α
T12319	20938-20942	NCBITaxon:10088	denotes	mice
T12320	20978-20984	PR:000013059	denotes	PGC-1α
T12321	20988-20992	NCBITaxon:10088	denotes	mice
T12322	20997-21003	PR:000013059	denotes	PGC-1α
T12323	21142-21154	UBERON:0025534	denotes	sensorimotor
T12324	21184-21190	PR:000013059	denotes	PGC-1α
T12325	21194-21198	NCBITaxon:10088	denotes	mice
T12326	21213-21219	PR:000013059	denotes	PGC-1α
T12327	21223-21227	NCBITaxon:10088	denotes	mice
T12328	21291-21297	PR:000013059	denotes	PGC-1α
T12329	21621-21629	UBERON:0004288	denotes	skeletal
T12330	21686-21692	PR:000013059	denotes	PGC-1α
T12331	21696-21700	NCBITaxon:10088	denotes	mice
T12332	21719-21725	PR:000013059	denotes	PGC-1α
T12333	21729-21733	NCBITaxon:10088	denotes	mice
T12334	21818-21824	PR:000013059	denotes	PGC-1α
T12335	21828-21832	NCBITaxon:10088	denotes	mice
T12336	21916-21922	PR:000013059	denotes	PGC-1α
T12337	21926-21930	NCBITaxon:10088	denotes	mice
T12338	21954-21960	PR:000013059	denotes	PGC-1α
T12339	21964-21968	NCBITaxon:10088	denotes	mice
T12340	22037-22043	PR:000013059	denotes	PGC-1α
T12341	22047-22051	NCBITaxon:10088	denotes	mice
T12342	22361-22367	PR:000013059	denotes	PGC-1α
T12343	22371-22375	NCBITaxon:10088	denotes	mice
T12344	22392-22394	CHEBI:15379	denotes	O2
T12345	22423-22429	PR:000013059	denotes	PGC-1α
T12346	22458-22460	CHEBI:15379	denotes	O2
T12347	22589-22602	UBERON:0001389	denotes	soleus muscle
T12348	22697-22710	GO:0005739	denotes	mitochondrial
T12349	22711-22725	GO:0006754	denotes	ATP production
T12350	22848-22854	PR:000013059	denotes	PGC-1α
T12351	22858-22862	NCBITaxon:10088	denotes	mice
T12352	22867-22873	PR:000013059	denotes	PGC-1α
T12353	23010-23022	GO:0006936	denotes	contractions
T12354	23055-23061	PR:000013059	denotes	PGC-1α
T12355	23065-23069	NCBITaxon:10088	denotes	mice
T12356	23096-23102	PR:000013059	denotes	PGC-1α
T12357	23201-23209	UBERON:0004288	denotes	skeletal
T12358	23217-23230	GO:0005739	denotes	mitochondrial
T12359	23269-23275	PR:000013059	denotes	PGC-1α
T12360	23304-23333	GO:0043501	denotes	adaptation of skeletal muscle
T12361	23318-23326	UBERON:0004288	denotes	skeletal
T14971	23387-23393	UBERON:0000948	denotes	Hearts
T14972	23397-23403	PR:000013059	denotes	PGC-1α
T14973	23407-23411	NCBITaxon:10088	denotes	Mice
T14974	23412-23418	PR:000013059	denotes	PGC-1α
T14975	23419-23429	GO:0010467	denotes	expression
T14976	23445-23450	UBERON:0000948	denotes	heart
T14977	23454-23460	UBERON:0000479	denotes	tissue
T14978	23484-23497	GO:0005739	denotes	mitochondrial
T14979	23505-23515	GO:0008152	denotes	metabolism
T14980	23561-23566	GO:0007567	denotes	natal
T14981	23567-23571	UBERON:0000104	denotes	life
T14982	23579-23597	NCBITaxon:40674	denotes	mammalian organism
T14983	23638-23644	PR:000013059	denotes	PGC-1α
T14984	23648-23652	NCBITaxon:10088	denotes	mice
T14985	23714-23721	UBERON:0004151	denotes	chamber
T14986	23731-23742	UBERON:0002082	denotes	ventricular
T14987	23796-23803	UBERON:0000948	denotes	Cardiac
T14988	23819-23828	GO:0008152	denotes	metabolic
T14989	23942-23948	PR:000013059	denotes	PGC-1α
T14990	23952-23956	NCBITaxon:10088	denotes	mice
T14991	24223-24229	PR:000013059	denotes	PGC-1α
T14992	24241-24248	NCBITaxon:33208	denotes	animals
T14993	24326-24332	PR:000013059	denotes	PGC-1α
T14994	24336-24340	NCBITaxon:10088	denotes	mice
T14995	24442-24448	PR:000013059	denotes	PGC-1α
T14996	24495-24501	PR:000013059	denotes	PGC-1α
T14997	24505-24509	NCBITaxon:10088	denotes	mice
T14998	24573-24589	UBERON:0002084	denotes	left ventricular
T14999	24616-24621	UBERON:0000948	denotes	heart
T15000	24700-24705	UBERON:0000948	denotes	heart
T15001	24718-24724	PR:000013059	denotes	PGC-1α
T15002	24728-24732	NCBITaxon:10088	denotes	mice
T15003	24859-24875	UBERON:0002084	denotes	left ventricular
T15004	24919-24925	PR:000013059	denotes	PGC-1α
T15005	24929-24933	NCBITaxon:10088	denotes	mice
T15006	24947-24953	PR:000013059	denotes	PGC-1α
T15007	24957-24961	NCBITaxon:10088	denotes	mice
T15008	26219-26226	UBERON:0000948	denotes	cardiac
T15009	26330-26338	UBERON:0004288	denotes	skeletal
T15010	26378-26385	UBERON:0000948	denotes	cardiac
T15011	26400-26406	UBERON:0000948	denotes	hearts
T15012	26410-26416	PR:000013059	denotes	PGC-1α
T15013	26424-26430	PR:000013059	denotes	PGC-1α
T15014	26434-26438	NCBITaxon:10088	denotes	mice
T15015	26487-26493	UBERON:0000948	denotes	Hearts
T15016	26508-26514	PR:000013059	denotes	PGC-1α
T15017	26518-26522	NCBITaxon:10088	denotes	mice
T15018	26539-26546	UBERON:0000948	denotes	cardiac
T15019	26553-26560	UBERON:0000948	denotes	cardiac
T15020	26618-26624	PR:000013059	denotes	PGC-1α
T15021	26628-26632	NCBITaxon:10088	denotes	mice
T15022	26694-26701	UBERON:0000948	denotes	cardiac
T15023	26728-26735	UBERON:0000948	denotes	cardiac
T15024	26783-26788	UBERON:0000948	denotes	heart
T15025	26826-26833	UBERON:0000948	denotes	cardiac
T15026	26848-26854	PR:000013059	denotes	PGC-1α
T15027	26858-26862	NCBITaxon:10088	denotes	mice
T15028	27011-27016	UBERON:0000948	denotes	heart
T15029	27026-27037	UBERON:0002082	denotes	ventricular
T15030	27119-27129	CHEBI:4670	denotes	dobutamine
T15031	27186-27197	UBERON:0002082	denotes	ventricular
T15032	27221-27231	CHEBI:4670	denotes	dobutamine
T15033	27247-27253	PR:000013059	denotes	PGC-1α
T15034	27261-27267	PR:000013059	denotes	PGC-1α
T15035	27271-27275	NCBITaxon:10088	denotes	mice
T15036	27311-27317	PR:000013059	denotes	PGC-1α
T15037	27321-27325	NCBITaxon:10088	denotes	mice
T15038	27360-27365	UBERON:0000948	denotes	heart
T15039	27502-27508	PR:000013059	denotes	PGC-1α
T15040	27512-27518	UBERON:0000948	denotes	hearts
T15041	27554-27566	GO:0002027	denotes	chronotropic
T15042	27658-27663	UBERON:0000948	denotes	heart
T15043	27714-27725	GO:0006936	denotes	contractile
T17172	27879-27885	PR:000013059	denotes	PGC-1α
T17173	27889-27893	NCBITaxon:10088	denotes	Mice
T17174	27914-27925	GO:0031649	denotes	Thermogenic
T17175	27935-27941	PR:000013059	denotes	PGC-1α
T17176	27991-28004	GO:0005739	denotes	mitochondrial
T17177	28005-28016	GO:0045333	denotes	respiratory
T17178	28052-28067	GO:0031649	denotes	heat production
T17179	28071-28074	UBERON:0001348	denotes	BAT
T17180	28101-28107	PR:000013059	denotes	PGC-1α
T17181	28140-28151	GO:0031649	denotes	thermogenic
T17182	28162-28168	PR:000013059	denotes	PGC-1α
T17183	28176-28182	PR:000013059	denotes	PGC-1α
T17184	28186-28190	NCBITaxon:10088	denotes	mice
T17185	28290-28296	PR:000013059	denotes	PGC-1α
T17186	28300-28304	NCBITaxon:10088	denotes	mice
T17187	28500-28506	PR:000013059	denotes	PGC-1α
T17188	28510-28514	NCBITaxon:10088	denotes	mice
T17189	28563-28569	PR:000013059	denotes	PGC-1α
T17190	28597-28608	GO:0031649	denotes	thermogenic
T17191	28647-28651	NCBITaxon:10088	denotes	mice
T17192	28689-28693	NCBITaxon:10088	denotes	mice
T17193	29874-29879	CHEBI:18059	denotes	lipid
T17194	29890-29893	UBERON:0001348	denotes	BAT
T17195	29947-29958	GO:0031649	denotes	thermogenic
T17196	29982-29988	PR:000013059	denotes	PGC-1α
T17197	29992-29996	NCBITaxon:10088	denotes	mice
T17198	30013-30018	CHEBI:18059	denotes	lipid
T17199	30058-30066	CHEBI:10545	denotes	Electron
T17200	30107-30120	GO:0005739	denotes	mitochondrial
T17201	30151-30154	UBERON:0001348	denotes	BAT
T17202	30169-30175	PR:000013059	denotes	PGC-1α
T17203	30183-30189	PR:000013059	denotes	PGC-1α
T17204	30193-30197	NCBITaxon:10088	denotes	mice
T17205	30272-30275	UBERON:0001348	denotes	BAT
T17206	30276-30288	CHEBI:17855	denotes	triglyceride
T17207	30348-30353	PR:000017035	denotes	UCP-1
T17208	30394-30407	GO:0005739	denotes	mitochondrial
T17209	30408-30419	GO:0045333	denotes	respiratory
T17210	30451-30454	UBERON:0001348	denotes	BAT
T17211	30456-30461	PR:000017035	denotes	UCP-1
T17212	30462-30466	SO:0000704	denotes	gene
T17213	30509-30515	PR:000013059	denotes	PGC-1α
T17214	30558-30561	UBERON:0001348	denotes	BAT
T17215	30562-30567	PR:000017035	denotes	UCP-1
T17216	30596-30602	PR:000013059	denotes	PGC-1α
T17217	30610-30616	PR:000013059	denotes	PGC-1α
T17218	30620-30624	NCBITaxon:10088	denotes	mice
T17219	30665-30671	PR:000013059	denotes	PGC-1α
T17220	30714-30724	GO:0010467	denotes	expression
T17221	30728-30733	PR:000017035	denotes	UCP-1
T17222	30807-30820	GO:0005739	denotes	mitochondrial
T17223	30821-30832	GO:0045333	denotes	respiration
T17224	30868-30879	GO:0031649	denotes	thermogenic
T17225	30896-30902	PR:000013059	denotes	PGC-1α
T17226	30906-30910	NCBITaxon:10088	denotes	mice
T17227	30912-30925	GO:0031649	denotes	Thermogenesis
T17228	30929-30936	NCBITaxon:9989	denotes	rodents
T17229	30948-30961	GO:0005739	denotes	mitochondrial
T17230	30986-30993	GO:0065007	denotes	control
T17231	31137-31143	PR:000013059	denotes	PGC-1α
T17232	31147-31151	NCBITaxon:10088	denotes	mice
T17233	31354-31360	PR:000013059	denotes	PGC-1α
T17234	31372-31378	PR:000013059	denotes	PGC-1α
T17235	31382-31386	NCBITaxon:10088	denotes	mice
T17236	31432-31441	GO:0008152	denotes	metabolic
T17237	31454-31457	UBERON:0001348	denotes	BAT
T17238	31543-31549	PR:000013059	denotes	PGC-1α
T17239	31555-31559	NCBITaxon:10088	denotes	mice
T17240	31600-31613	GO:0005739	denotes	mitochondrial
T17241	31614-31625	GO:0045333	denotes	respiratory
T19912	31655-31662	UBERON:0002107	denotes	Hepatic
T19913	31676-31682	PR:000013059	denotes	PGC-1α
T19914	31686-31690	NCBITaxon:10088	denotes	Mice
T19915	31724-31730	PR:000013059	denotes	PGC-1α
T19916	31742-31749	UBERON:0002107	denotes	hepatic
T19917	31750-31759	GO:0008152	denotes	metabolic
T19918	31780-31790	CHEBI:35366	denotes	fatty acid
T19919	31780-31800	GO:0019395	denotes	fatty acid oxidation
T19920	31791-31800	MOP:0000568	denotes	oxidation
T19921	31805-31820	GO:0006094	denotes	gluconeogenesis
T19922	31853-31860	UBERON:0002107	denotes	hepatic
T19923	31962-31972	CHEBI:35366	denotes	fatty acid
T19924	31962-31982	GO:0019395	denotes	fatty acid oxidation
T19925	31973-31982	MOP:0000568	denotes	oxidation
T19926	31987-32000	GO:0006094	denotes	gluconeogenic
T19927	32010-32015	UBERON:0002107	denotes	liver
T19928	32029-32032	GO:0007631	denotes	fed
T19929	32049-32055	UBERON:0002107	denotes	livers
T19930	32063-32069	PR:000013059	denotes	PGC-1α
T19931	32073-32077	NCBITaxon:10088	denotes	mice
T19932	32203-32209	PR:000013059	denotes	PGC-1α
T19933	32213-32217	NCBITaxon:10088	denotes	mice
T19934	32235-32242	UBERON:0002107	denotes	hepatic
T19935	32308-32316	CHEBI:10545	denotes	electron
T19936	32349-32354	UBERON:0002107	denotes	liver
T19937	32355-32367	CHEBI:17855	denotes	triglyceride
T19938	32369-32372	CHEBI:17855	denotes	TAG
T19939	32422-32428	UBERON:0001969	denotes	plasma
T19940	32429-32442	CHEBI:17855	denotes	triglycerides
T19941	32451-32462	CHEBI:35366	denotes	fatty acids
T19942	32488-32491	GO:0007631	denotes	fed
T19943	32599-32606	UBERON:0002107	denotes	hepatic
T19944	32627-32638	CL:0000182	denotes	hepatocytes
T19945	32658-32664	PR:000013059	denotes	PGC-1α
T19946	32668-32672	NCBITaxon:10088	denotes	mice
T19947	32690-32696	CHEBI:30823	denotes	Oleate
T19948	32735-32741	PR:000013059	denotes	PGC-1α
T19949	32745-32756	CL:0000182	denotes	hepatocytes
T19950	32777-32782	CHEBI:18059	denotes	lipid
T19951	32848-32850	CHEBI:29238	denotes	3H
T19952	32851-32860	CHEBI:7896	denotes	palmitate
T19953	32861-32870	MOP:0000568	denotes	oxidation
T19954	32905-32911	PR:000013059	denotes	PGC-1α
T19955	32915-32926	CL:0000182	denotes	hepatocytes
T19956	32939-32945	PR:000013059	denotes	PGC-1α
T19957	32949-32960	CL:0000182	denotes	hepatocytes
T19958	33010-33016	CHEBI:30823	denotes	oleate
T19959	33104-33110	PR:000013059	denotes	PGC-1α
T19960	33114-33125	CL:0000182	denotes	hepatocytes
T19961	33176-33181	CHEBI:18059	denotes	lipid
T19962	33218-33235	GO:0006869	denotes	delivery of lipid
T19963	33230-33235	CHEBI:18059	denotes	lipid
T19964	35167-35174	UBERON:0002107	denotes	hepatic
T19965	35175-35188	GO:0005739	denotes	mitochondrial
T19966	35189-35199	CHEBI:35366	denotes	fatty acid
T19967	35189-35209	GO:0019395	denotes	fatty acid oxidation
T19968	35200-35209	MOP:0000568	denotes	oxidation
T19969	35217-35221	SO:0000704	denotes	gene
T19970	35217-35232	GO:0010467	denotes	gene expression
T19971	35266-35272	PR:000013059	denotes	PGC-1α
T19972	35352-35358	PR:000013059	denotes	PGC-1α
T19973	35362-35366	NCBITaxon:10088	denotes	mice
T19974	35386-35396	GO:0010467	denotes	expression
T19975	35412-35417	SO:0000704	denotes	genes
T19976	35454-35459	SO:0000704	denotes	genes
T19977	35464-35468	SO:0000704	denotes	gene
T19978	35464-35479	GO:0010467	denotes	gene expression
T19979	35536-35543	UBERON:0002107	denotes	hepatic
T19980	35544-35554	GO:0010467	denotes	expression
T19981	35570-35575	SO:0000704	denotes	genes
T19982	35597-35607	CHEBI:35366	denotes	fatty acid
T19983	35612-35621	MOP:0000568	denotes	oxidation
T19984	35623-35627	PR:000005836	denotes	MCPT
T19985	35699-35702	GO:0007631	denotes	fed
T19986	35816-35825	MOP:0000568	denotes	oxidation
T19987	35833-35844	CL:0000182	denotes	hepatocytes
T19988	35852-35858	PR:000013059	denotes	PGC-1α
T19989	35862-35866	NCBITaxon:10088	denotes	mice
T19990	35890-35903	GO:0005739	denotes	mitochondrial
T19991	35904-35915	GO:0045333	denotes	respiratory
T19992	35955-35961	PR:000013059	denotes	PGC-1α
T19993	35965-35976	CL:0000182	denotes	hepatocytes
T19994	36050-36061	GO:0045333	denotes	respiration
T19995	36164-36171	UBERON:0002107	denotes	hepatic
T19996	36208-36217	MOP:0000568	denotes	oxidation
T19997	36225-36238	GO:0005739	denotes	mitochondrial
T19998	36239-36250	GO:0045333	denotes	respiratory
T19999	36959-36964	UBERON:0002107	denotes	liver
T20000	36965-36969	SO:0000704	denotes	gene
T20001	36965-36980	GO:0010467	denotes	gene expression
T20002	37035-37045	CHEBI:35366	denotes	fatty acid
T20003	37035-37055	GO:0019395	denotes	fatty acid oxidation
T20004	37046-37055	MOP:0000568	denotes	oxidation
T20005	37071-37077	PR:000013059	denotes	PGC-1α
T20006	37081-37085	NCBITaxon:10088	denotes	mice
T20007	37142-37148	CHEBI:15889	denotes	sterol
T20008	37142-37167	SO:0001861	denotes	sterol regulatory element
T20009	37142-37183	PR:000028988	denotes	sterol regulatory element binding protein
T20010	37149-37159	GO:0065007	denotes	regulatory
T20011	37188-37193	PR:000028988	denotes	SREBP
T20012	37272-37277	PR:000028988	denotes	SREBP
T20013	37296-37300	SO:0000704	denotes	gene
T20014	37301-37313	CHEBI:15541	denotes	stearoyl-CoA
T20015	37326-37330	PR:000015921	denotes	SCD1
T20016	37350-37356	PR:000013059	denotes	PGC-1α
T20017	37360-37364	NCBITaxon:10088	denotes	mice
T20018	37389-37399	GO:0010467	denotes	expression
T20019	37407-37411	SO:0000704	denotes	gene
T20020	37421-37432	CHEBI:18035	denotes	diglyceride
T20021	37490-37493	CHEBI:17855	denotes	TAG
T20022	37490-37503	GO:0019432	denotes	TAG synthesis
T20023	37576-37582	PR:000013059	denotes	PGC-1α
T20024	37586-37590	NCBITaxon:10088	denotes	mice
T20025	37657-37666	MOP:0000568	denotes	oxidation
T20026	37686-37689	CHEBI:17855	denotes	TAG
T20027	37686-37699	GO:0019432	denotes	TAG synthesis
T20028	37729-37735	PR:000013059	denotes	PGC-1α
T20029	37739-37743	NCBITaxon:10088	denotes	mice
T20030	37793-37795	CHEBI:29238	denotes	3H
T20031	37796-37804	CHEBI:17754	denotes	glycerol
T20032	37824-37827	CHEBI:17855	denotes	TAG
T20033	37856-37867	CL:0000182	denotes	hepatocytes
T20034	37869-37871	CHEBI:29238	denotes	3H
T20035	37872-37875	CHEBI:17855	denotes	TAG
T20036	37918-37929	CL:0000182	denotes	hepatocytes
T20037	37944-37950	PR:000013059	denotes	PGC-1α
T20038	37954-37958	NCBITaxon:10088	denotes	mice
T20039	37971-37977	PR:000013059	denotes	PGC-1α
T20040	38019-38022	CHEBI:17855	denotes	TAG
T20041	38019-38032	GO:0019432	denotes	TAG synthesis
T20042	38056-38062	PR:000013059	denotes	PGC-1α
T20043	38068-38079	CL:0000182	denotes	hepatocytes
T20044	38158-38165	UBERON:0002107	denotes	hepatic
T22368	38217-38223	PR:000013059	denotes	PGC-1α
T22369	38227-38231	NCBITaxon:10088	denotes	Mice
T22370	38247-38254	PR:000045358	denotes	Insulin
T22371	38310-38316	PR:000013059	denotes	PGC-1α
T22372	38317-38348	SO:0000694	denotes	single nucleotide polymorphisms
T22373	38353-38363	SO:0001024	denotes	haplotypes
T22374	38397-38404	PR:000045358	denotes	insulin
T22375	38478-38485	PR:000045358	denotes	insulin
T22376	38549-38556	CHEBI:17234	denotes	glucose
T22377	38570-38577	PR:000045358	denotes	insulin
T22378	38610-38616	PR:000013059	denotes	PGC-1α
T22379	38620-38624	NCBITaxon:10088	denotes	mice
T22380	38626-38633	CHEBI:17234	denotes	Glucose
T22381	38680-38684	NCBITaxon:10088	denotes	mice
T22382	38723-38728	UBERON:0000178	denotes	blood
T22383	38729-38736	CHEBI:17234	denotes	glucose
T22384	38755-38761	PR:000013059	denotes	PGC-1α
T22385	38769-38775	PR:000013059	denotes	PGC-1α
T22386	38830-38836	PR:000013059	denotes	PGC-1α
T22387	38840-38844	NCBITaxon:10088	denotes	mice
T22388	38885-38892	CHEBI:17234	denotes	glucose
T22389	38907-38914	PR:000045358	denotes	insulin
T22390	38968-38975	CHEBI:17234	denotes	Glucose
T22391	39015-39021	PR:000013059	denotes	PGC-1α
T22392	39025-39029	NCBITaxon:10088	denotes	mice
T22393	39126-39132	PR:000013059	denotes	PGC-1α
T22394	39136-39140	NCBITaxon:10088	denotes	mice
T22395	39158-39164	PR:000013059	denotes	PGC-1α
T22396	39168-39172	NCBITaxon:10088	denotes	mice
T22397	39191-39197	PR:000013059	denotes	PGC-1α
T22398	39201-39205	NCBITaxon:10088	denotes	mice
T22399	39234-39241	CHEBI:17234	denotes	glucose
T22400	39267-39271	NCBITaxon:10088	denotes	mice
T22401	39284-39290	NCBITaxon:9989	denotes	rodent
T22402	39291-39295	CHEBI:33290	denotes	chow
T22403	39319-39326	CHEBI:17234	denotes	glucose
T22404	39319-39338	GO:0042593	denotes	glucose homeostasis
T22405	39376-39382	PR:000013059	denotes	PGC-1α
T22406	39390-39396	PR:000013059	denotes	PGC-1α
T22407	39400-39404	NCBITaxon:10088	denotes	mice
T22408	39429-39433	CHEBI:33290	denotes	chow
T22409	39551-39557	PR:000013059	denotes	PGC-1α
T22410	39565-39571	PR:000013059	denotes	PGC-1α
T22411	39613-39619	PR:000013059	denotes	PGC-1α
T22412	39623-39627	NCBITaxon:10088	denotes	mice
T22413	39671-39678	CHEBI:17234	denotes	glucose
T22414	39692-39699	PR:000045358	denotes	insulin
T22415	39726-39732	PR:000013059	denotes	PGC-1α
T22416	39736-39740	NCBITaxon:10088	denotes	mice
T22417	39861-39867	PR:000013059	denotes	PGC-1α
T22418	39871-39875	NCBITaxon:10088	denotes	mice
T22419	39891-39898	PR:000045358	denotes	insulin
T22420	39925-39931	PR:000013059	denotes	PGC-1α
T22421	39935-39939	NCBITaxon:10088	denotes	mice
T22422	39949-39956	CHEBI:17234	denotes	glucose
T22423	39970-39977	PR:000045358	denotes	insulin
T22424	39996-40000	NCBITaxon:10088	denotes	mice
T23897	40735-40757	UBERON:0001017	denotes	Central Nervous System
T23898	40761-40767	PR:000013059	denotes	PGC-1α
T23899	40771-40775	NCBITaxon:10088	denotes	Mice
T23900	40793-40800	UBERON:0000479	denotes	tissues
T23901	40808-40814	PR:000013059	denotes	PGC-1α
T23902	40818-40822	NCBITaxon:10088	denotes	mice
T23903	40856-40861	UBERON:0000955	denotes	brain
T23904	40910-40916	PR:000013059	denotes	PGC-1α
T23905	40920-40925	UBERON:0000955	denotes	brain
T23906	40926-40932	UBERON:0000479	denotes	tissue
T23907	40971-40988	UBERON:0000956	denotes	cerebral cortical
T23908	40971-40997	CL:0010012	denotes	cerebral cortical neuronal
T23909	41047-41053	CL:0000540	denotes	neuron
T23910	41081-41094	UBERON:0001872	denotes	parietal lobe
T23911	41096-41102	PR:000013059	denotes	PGC-1α
T23912	41118-41125	CL:0000540	denotes	neurons
T23913	41137-41143	PR:000013059	denotes	PGC-1α
T23914	41159-41166	CL:0000540	denotes	neurons
T23915	41237-41245	UBERON:0002606	denotes	neuropil
T23916	41261-41278	CL:0000598	denotes	pyramidal neurons
T23917	41305-41320	UBERON:0000956	denotes	cerebral cortex
T23918	41339-41345	PR:000013059	denotes	PGC-1α
T23919	41349-41353	NCBITaxon:10088	denotes	mice
T23920	41366-41372	PR:000013059	denotes	PGC-1α
T23921	41376-41380	NCBITaxon:10088	denotes	mice
T23922	41420-41430	CL:0000127	denotes	astrocytic
T23923	41439-41444	CL:0000125	denotes	glial
T23924	41439-41470	PR:000007939	denotes	glial fibrillary acidic protein
T23925	41456-41462	CHEBI:37527	denotes	acidic
T23926	41513-41523	CL:0000127	denotes	astrocytic
T23927	41513-41533	GO:0097449	denotes	astrocytic processes
T23928	41537-41543	PR:000013059	denotes	PGC-1α
T23929	41547-41552	NCBITaxon:10088	denotes	mouse
T23930	41553-41568	UBERON:0000956	denotes	cerebral cortex
T23931	41617-41625	CL:0000540	denotes	neuronal
T23932	41679-41694	UBERON:0016530	denotes	parietal cortex
T23933	41720-41728	UBERON:0002606	denotes	neuropil
T23934	41733-41740	CL:0000540	denotes	neurons
T23935	41748-41754	PR:000013059	denotes	PGC-1α
T23936	41758-41771	UBERON:0002420	denotes	basal ganglia
T23937	41773-41780	UBERON:0001873	denotes	caudate
T23938	41785-41792	UBERON:0001874	denotes	putamen
T23939	41878-41883	CL:0000125	denotes	glial
T23940	41878-41909	PR:000007939	denotes	glial fibrillary acidic protein
T23941	41895-41901	CHEBI:37527	denotes	acidic
T23942	41925-41935	CL:0000127	denotes	astrocytic
T23943	41925-41945	GO:0097449	denotes	astrocytic processes
T23944	42015-42024	UBERON:0002298	denotes	brainstem
T23945	42055-42063	_FRAGMENT	denotes	Purkinje
T23946	42076-42088	CL:0000121	denotes	cell neurons
T23947	42068-42088	CL:0000120	denotes	granule cell neurons
T23948	42112-42118	PR:000013059	denotes	PGC-1α
T23949	42122-42139	UBERON:0002129	denotes	cerebellar cortex
T23950	42149-42159	CL:0000129	denotes	microglial
T23951	42149-42173	GO:0061518	denotes	microglial proliferation
T23952	42178-42190	UBERON:0014930	denotes	perivascular
T23953	42191-42202	CL:0000542	denotes	lymphocytic
T23954	42246-42252	PR:000013059	denotes	PGC-1α
T23955	42256-42259	UBERON:0001017	denotes	CNS
T23956	42878-42884	PR:000013059	denotes	PGC-1α
T23957	42888-42896	UBERON:0001872	denotes	parietal
T23958	42897-42912	UBERON:0000956	denotes	cerebral cortex
T23959	42955-42962	CL:0000540	denotes	neurons
T23960	42967-42975	UBERON:0002606	denotes	neuropil
T23961	42990-42998	GO:0005773	denotes	Vacuoles
T23962	43024-43034	GO:0016020	denotes	membranous
T23963	43072-43080	UBERON:0001851	denotes	cortical
T23964	43072-43088	CL:0010012	denotes	cortical neurons
T23965	43122-43130	GO:0005773	denotes	vacuoles
T23966	43205-43213	UBERON:0002606	denotes	neuropil
T23967	43227-43237	GO:0006909	denotes	phagocytic
T23968	43227-43243	CL:0000234	denotes	phagocytic cells
T23969	43245-43256	GO:0098793	denotes	presynaptic
T23970	43257-43262	UBERON:0001021	denotes	nerve
T23971	43289-43293	GO:0044297	denotes	soma
T23972	43311-43321	GO:0043204	denotes	perikaryal
T29560	43427-43433	PR:000013059	denotes	PGC-1α
T29561	43514-43533	GO:0008152	denotes	metabolic processes
T29562	43544-43554	CHEBI:35366	denotes	fatty acid
T29563	43544-43564	GO:0019395	denotes	fatty acid oxidation
T29564	43555-43564	MOP:0000568	denotes	oxidation
T29565	43566-43574	CHEBI:10545	denotes	electron
T29566	43566-43584	MOP:0000615	denotes	electron transport
T29567	43590-43599	MOP:0000568	denotes	oxidative
T29568	43590-43615	GO:0006119	denotes	oxidative phosphorylation
T29569	43628-43638	GO:0010467	denotes	expression
T29570	43642-43648	PR:000013059	denotes	PGC-1α
T29571	43658-43671	GO:0005739	denotes	mitochondrial
T29572	43738-43743	PR:000011422	denotes	NRF-1
T29573	43760-43766	SO:0000910	denotes	orphan
T29574	43767-43774	GO:0005634	denotes	nuclear
T29575	43784-43792	CHEBI:50114	denotes	estrogen
T29576	43784-43811	PR:000007208	denotes	estrogen-related receptor α
T29577	43883-43889	PR:000013059	denotes	PGC-1α
T29578	43923-43942	GO:0008152	denotes	metabolic processes
T29579	43953-43966	GO:0005739	denotes	mitochondrial
T29580	44007-44011	SO:0000704	denotes	gene
T29581	44024-44028	NCBITaxon:10088	denotes	mice
T29582	44048-44054	PR:000013059	denotes	PGC-1α
T29583	44083-44094	UBERON:0000922	denotes	embryologic
T29584	44083-44106	GO:0009790	denotes	embryologic development
T29585	44136-44149	GO:0005739	denotes	mitochondrial
T29586	44225-44231	PR:000013059	denotes	PGC-1α
T29587	44267-44275	GO:0065007	denotes	regulate
T29588	44280-44285	GO:0007567	denotes	natal
T29589	44286-44299	GO:0005739	denotes	mitochondrial
T29590	44313-44321	_FRAGMENT	denotes	cellular
T29591	44329-44339	GO:0044237	denotes	metabolism
T29592	44366-44374	NCBITaxon:1	denotes	organism
T29593	44390-44399	GO:0008152	denotes	metabolic
T29594	44418-44423	GO:0007567	denotes	natal
T29595	44444-44457	GO:0005739	denotes	mitochondrial
T29596	44490-44517	UBERON:0006907	denotes	slow-twitch skeletal muscle
T29597	44521-44527	PR:000013059	denotes	PGC-1α
T29598	44531-44535	NCBITaxon:10088	denotes	mice
T29599	44545-44558	GO:0005739	denotes	mitochondrial
T29600	44559-44570	GO:0045333	denotes	respiratory
T29601	44621-44629	UBERON:0004288	denotes	skeletal
T29602	44641-44646	UBERON:0002107	denotes	liver
T29603	44650-44656	PR:000013059	denotes	PGC-1α
T29604	44660-44664	NCBITaxon:10088	denotes	mice
T29605	44687-44692	UBERON:0000948	denotes	heart
T29606	44697-44710	UBERON:0001389	denotes	soleus muscle
T29607	44712-44719	UBERON:0000479	denotes	tissues
T29608	44742-44755	GO:0005739	denotes	mitochondrial
T29609	44795-44802	GO:0065007	denotes	control
T29610	44839-44845	PR:000013059	denotes	PGC-1α
T29611	44849-44853	NCBITaxon:10088	denotes	mice
T29612	44864-44870	PR:000013059	denotes	PGC-1α
T29613	44874-44878	NCBITaxon:10088	denotes	mice
T29614	44970-44979	MOP:0000568	denotes	oxidative
T29615	45048-45054	PR:000013059	denotes	PGC-1α
T29616	45095-45108	GO:0005739	denotes	mitochondrial
T29617	45168-45173	GO:0007567	denotes	natal
T29618	45235-45239	NCBITaxon:10088	denotes	mice
T29619	45248-45254	PR:000013059	denotes	PGC-1α
T29620	45317-45322	GO:0007567	denotes	natal
T29621	45348-45356	UBERON:0004288	denotes	skeletal
T29622	45390-45396	PR:000013059	denotes	PGC-1α
T29623	45400-45404	NCBITaxon:10088	denotes	mice
T29624	45541-45547	PR:000013059	denotes	PGC-1α
T29625	45551-45555	NCBITaxon:10088	denotes	mice
T29626	45638-45645	UBERON:0000948	denotes	cardiac
T29627	45661-45667	PR:000013059	denotes	PGC-1α
T29628	45671-45675	NCBITaxon:10088	denotes	mice
T29629	45762-45767	UBERON:0000948	denotes	heart
T29630	45827-45834	UBERON:0000948	denotes	cardiac
T29631	45835-45840	UBERON:0000948	denotes	heart
T29632	46022-46032	GO:0008152	denotes	metabolism
T29633	46036-46046	UBERON:0002351	denotes	sinus node
T29634	46057-46063	PR:000013059	denotes	PGC-1α
T29635	46152-46158	PR:000013059	denotes	PGC-1α
T29636	46162-46166	NCBITaxon:10088	denotes	mice
T29637	46301-46314	GO:0031649	denotes	thermogenesis
T29638	46348-46353	PR:000017035	denotes	UCP-1
T29639	46362-46365	UBERON:0001348	denotes	BAT
T29640	46385-46403	CHEBI:37886	denotes	adrenergic agonist
T29641	46455-46466	GO:0031649	denotes	thermogenic
T29642	46467-46473	UBERON:0000479	denotes	tissue
T29643	46491-46497	PR:000013059	denotes	PGC-1α
T29644	46501-46505	NCBITaxon:10088	denotes	mice
T29645	46527-46538	GO:0031649	denotes	thermogenic
T29646	46584-46597	GO:0005739	denotes	mitochondrial
T29647	46598-46609	GO:0045333	denotes	respiration
T29648	46613-46616	UBERON:0001348	denotes	BAT
T29649	46702-46707	GO:0007567	denotes	natal
T29650	46708-46712	UBERON:0000104	denotes	life
T29651	46714-46721	NCBITaxon:33208	denotes	Animals
T29652	46896-46902	PR:000013059	denotes	PGC-1α
T29653	46953-46963	_FRAGMENT	denotes	control of
T29654	46971-46981	GO:0019222	denotes	metabolism
T29655	47018-47025	UBERON:0002107	denotes	hepatic
T29656	47075-47081	PR:000013059	denotes	PGC-1α
T29657	47085-47089	NCBITaxon:10088	denotes	mice
T29658	47108-47113	GO:0007567	denotes	natal
T29659	47128-47137	GO:0008152	denotes	metabolic
T29660	47198-47204	PR:000013059	denotes	PGC-1α
T29661	47208-47212	NCBITaxon:10088	denotes	mice
T29662	47230-47240	CL:0000182	denotes	hepatocyte
T29663	47241-47253	CHEBI:17855	denotes	triglyceride
T29664	47299-47308	CHEBI:7896	denotes	palmitate
T29665	47309-47318	MOP:0000568	denotes	oxidation
T29666	47341-47352	CL:0000182	denotes	hepatocytes
T29667	47371-47377	PR:000013059	denotes	PGC-1α
T29668	47381-47385	NCBITaxon:10088	denotes	mice
T29669	47413-47418	CHEBI:18059	denotes	lipid
T29670	47464-47474	CHEBI:35366	denotes	fatty acid
T29671	47464-47484	GO:0019395	denotes	fatty acid oxidation
T29672	47475-47484	MOP:0000568	denotes	oxidation
T29673	47494-47500	PR:000013059	denotes	PGC-1α
T29674	47506-47517	CL:0000182	denotes	hepatocytes
T29675	47541-47551	GO:0010467	denotes	expression
T29676	47555-47561	PR:000013059	denotes	PGC-1α
T29677	47574-47579	SO:0000704	denotes	genes
T29678	47592-47605	GO:0005739	denotes	mitochondrial
T29679	47606-47616	CHEBI:35366	denotes	fatty acid
T29680	47606-47626	GO:0019395	denotes	fatty acid oxidation
T29681	47617-47626	MOP:0000568	denotes	oxidation
T29682	47637-47650	GO:0005739	denotes	mitochondrial
T29683	47651-47662	GO:0045333	denotes	respiratory
T29684	47713-47725	CHEBI:17855	denotes	triglyceride
T29685	47713-47735	GO:0019432	denotes	triglyceride synthesis
T29686	47770-47780	GO:0010467	denotes	expression
T29687	47784-47789	SO:0000704	denotes	genes
T29688	47799-47804	PR:000028988	denotes	SREBP
T29689	47812-47817	PR:000015921	denotes	SCD-1
T29690	47839-47846	UBERON:0002107	denotes	hepatic
T29691	47847-47856	GO:0008610	denotes	lipogenic
T29692	47918-47924	PR:000013059	denotes	PGC-1α
T29693	47928-47932	NCBITaxon:10088	denotes	mice
T29694	48039-48051	CHEBI:17855	denotes	triglyceride
T29695	48039-48061	GO:0019432	denotes	triglyceride synthesis
T29696	48197-48203	PR:000013059	denotes	PGC-1α
T29697	48225-48230	SO:0000704	denotes	genes
T29698	48271-48281	CL:0000182	denotes	hepatocyte
T29699	48282-48292	CHEBI:35366	denotes	fatty acid
T29700	48378-48384	PR:000013059	denotes	PGC-1α
T29701	48401-48408	GO:0005634	denotes	nuclear
T29702	48418-48421	PR:000011396	denotes	FXR
T29703	48447-48452	PR:000028988	denotes	SREBP
T29704	48456-48466	GO:0010467	denotes	expression
T29705	48471-48483	CHEBI:17855	denotes	triglyceride
T29706	48471-48493	GO:0019432	denotes	triglyceride synthesis
T29707	48525-48535	CL:0000182	denotes	hepatocyte
T29708	48536-48549	GO:0005739	denotes	mitochondrial
T29709	48550-48561	GO:0045333	denotes	respiratory
T29710	48599-48608	GO:0008610	denotes	lipogenic
T29711	48629-48639	CL:0000182	denotes	hepatocyte
T29712	48640-48652	CHEBI:17855	denotes	triglyceride
T29713	48694-48701	UBERON:0002107	denotes	hepatic
T29714	48702-48725	GO:0015908	denotes	delivery of fatty acids
T29715	48714-48725	CHEBI:35366	denotes	fatty acids
T29716	48796-48802	PR:000013059	denotes	PGC-1α
T29717	48806-48810	NCBITaxon:10088	denotes	mice
T29718	48973-48978	GO:0007568	denotes	aging
T29719	49049-49055	PR:000013059	denotes	PGC-1α
T29720	49059-49063	NCBITaxon:10088	denotes	mice
T29721	49135-49142	GO:0065007	denotes	control
T29722	49186-49190	CHEBI:33290	denotes	food
T29723	49186-49197	GO:0007631	denotes	food intake
T29724	49227-49233	PR:000013059	denotes	PGC-1α
T29725	49237-49241	NCBITaxon:10088	denotes	mice
T29726	49322-49335	GO:0005739	denotes	mitochondrial
T29727	49400-49406	PR:000013059	denotes	PGC-1α
T29728	49410-49414	NCBITaxon:10088	denotes	mice
T29729	49454-49460	PR:000013059	denotes	PGC-1α
T29730	49461-49465	SO:0000704	denotes	gene
T29731	49495-49501	NCBITaxon:9606	denotes	humans
T29732	49578-49584	PR:000013059	denotes	PGC-1α
T29733	49588-49592	NCBITaxon:10088	denotes	mice
T29734	49717-49724	GO:0065007	denotes	control
T29735	49776-49783	CHEBI:17234	denotes	glucose
T29736	49799-49806	PR:000045358	denotes	insulin
T29737	49825-49831	PR:000013059	denotes	PGC-1α
T29738	49835-49842	NCBITaxon:33208	denotes	animals
T29739	49855-49859	CHEBI:33290	denotes	chow
T29740	49878-49884	PR:000013059	denotes	PGC-1α
T29741	49888-49892	NCBITaxon:10088	denotes	mice
T29742	49903-49910	CHEBI:17234	denotes	glucose
T29743	49924-49931	PR:000045358	denotes	insulin
T29744	49947-49953	PR:000013059	denotes	PGC-1α
T29745	49971-49980	GO:0007631	denotes	consuming
T29746	50095-50105	GO:0010467	denotes	expression
T29747	50109-50115	PR:000013059	denotes	PGC-1α
T29748	50119-50124	NCBITaxon:9606	denotes	human
T29749	50134-50142	UBERON:0004288	denotes	skeletal
T29750	50202-50222	GO:0019222	denotes	metabolic regulatory
T29751	50261-50267	PR:000013059	denotes	PGC-1α
T29752	50278-50282	NCBITaxon:10088	denotes	mice
T29753	50332-50338	PR:000013059	denotes	PGC-1α
T29754	50405-50412	PR:000045358	denotes	insulin
T29755	50484-50488	NCBITaxon:10088	denotes	mice
T29756	50501-50507	PR:000013059	denotes	PGC-1α
T29757	50555-50562	CHEBI:17234	denotes	glucose
T29758	50613-50619	PR:000013059	denotes	PGC-1α
T29759	50623-50627	NCBITaxon:10088	denotes	mice
T29760	50674-50696	UBERON:0001017	denotes	central nervous system
T29761	50739-50745	UBERON:0000955	denotes	brains
T29762	50749-50755	PR:000013059	denotes	PGC-1α
T29763	50759-50763	NCBITaxon:10088	denotes	mice
T29764	50813-50830	CL:0000598	denotes	pyramidal neurons
T29765	50823-50833	_FRAGMENT	denotes	neurons of
T29766	50838-50853	CL:0010012	denotes	cerebral cortex
T29767	50838-50853	UBERON:0000956	denotes	cerebral cortex
T29768	50903-50913	CL:0000127	denotes	astrocytes
T29769	50921-50934	UBERON:0002420	denotes	basal ganglia
T29770	51034-51040	PR:000013059	denotes	PGC-1α
T29771	51068-51073	CHEBI:18059	denotes	lipid
T29772	51068-51084	GO:0006629	denotes	lipid metabolism
T29773	51096-51104	GO:0016020	denotes	membrane
T29774	51096-51114	GO:0044091	denotes	membrane synthesis
T29775	51236-51246	CL:0000129	denotes	microglial
T29776	51264-51286	UBERON:0001017	denotes	central nervous system
T29777	51303-51313	UBERON:0001016	denotes	neurologic
T29778	51346-51352	PR:000013059	denotes	PGC-1α
T29779	51356-51360	NCBITaxon:10088	denotes	mice
T29780	51386-51390	UBERON:0000104	denotes	life
T29781	51439-51451	UBERON:0025534	denotes	sensorimotor
T29782	51464-51470	PR:000013059	denotes	PGC-1α
T29783	51474-51478	NCBITaxon:10088	denotes	mice
T29784	51595-51601	PR:000013059	denotes	PGC-1α
T29785	51605-51609	NCBITaxon:10088	denotes	mice
T29786	51632-51642	_FRAGMENT	denotes	peripheral
T29787	51654-51668	UBERON:0000010	denotes	nervous system
T29788	51646-51668	UBERON:0001017	denotes	central nervous system
T29789	51771-51780	GO:0040011	denotes	locomotor
T29790	51836-51841	UBERON:0000955	denotes	brain
T29791	51854-51860	PR:000013059	denotes	PGC-1α
T29792	51864-51868	NCBITaxon:10088	denotes	mice
T29793	51918-51928	UBERON:0001016	denotes	neurologic
T29794	51970-51979	GO:0008152	denotes	metabolic
T29795	52001-52007	PR:000013059	denotes	PGC-1α
T29796	52013-52017	NCBITaxon:10088	denotes	mice
T29797	52097-52102	NCBITaxon:10088	denotes	mouse
T29798	52121-52127	PR:000013059	denotes	PGC-1α
T29799	52128-52132	SO:0000704	denotes	gene
T29800	52185-52191	PR:000013059	denotes	PGC-1α
T29801	52306-52312	PR:000013059	denotes	PGC-1α
T29802	52363-52373	CL:0000182	denotes	hepatocyte
T29803	52374-52385	GO:0045333	denotes	respiration
T29804	52397-52407	UBERON:0001016	denotes	neurologic
T29805	52513-52519	PR:000013059	denotes	PGC-1α
T29806	52523-52527	NCBITaxon:10088	denotes	mice
T29807	52566-52571	GO:0007567	denotes	natal
T29808	52632-52647	GO:0006094	denotes	gluconeogenesis
T29809	52665-52670	UBERON:0000178	denotes	blood
T29810	52671-52678	CHEBI:17234	denotes	glucose
T29811	52756-52766	GO:0010467	denotes	expression
T29812	52779-52811	PR:000005308	denotes	CCAAT-enhancer-binding protein β
T29813	52779-52809	_FRAGMENT	denotes	CCAAT-enhancer-binding protein
T29814	52816-52817	PR:000005309	denotes	δ
T29815	52785-52793	SO:0000165	denotes	enhancer
T29816	52826-52839	GO:0006094	denotes	gluconeogenic
T29817	52840-52845	SO:0000704	denotes	genes
T29818	52855-52874	CHEBI:18021	denotes	phosphoenolpyruvate
T29819	52893-52900	CHEBI:17234	denotes	glucose
T29820	52951-52957	PR:000013059	denotes	PGC-1α
T29821	52961-52965	NCBITaxon:10088	denotes	mice
T29822	53066-53072	PR:000013059	denotes	PGC-1α
T29823	53076-53080	NCBITaxon:10088	denotes	mice
T29824	53196-53203	PR:000045358	denotes	insulin
T29825	53245-53251	PR:000013059	denotes	PGC-1α
T29826	53262-53266	NCBITaxon:10088	denotes	mice
T29827	53362-53369	PR:000045358	denotes	insulin
T29828	53404-53410	PR:000013059	denotes	PGC-1α
T29829	53414-53418	NCBITaxon:10088	denotes	mice
T29830	53524-53531	PR:000045358	denotes	insulin
T29831	53555-53561	PR:000013059	denotes	PGC-1α
T29832	53565-53569	NCBITaxon:10088	denotes	mice
T29833	53630-53634	NCBITaxon:10088	denotes	mice
T29834	53647-53654	GO:0005634	denotes	nuclear
T29835	53664-53672	CHEBI:50114	denotes	estrogen
T29836	53664-53691	PR:000007208	denotes	estrogen-related receptor α
T29837	53711-53717	PR:000013059	denotes	PGC-1α
T29838	53786-53792	PR:000013059	denotes	PGC-1α
T29839	53798-53802	NCBITaxon:10088	denotes	mice
T29840	53821-53827	PR:000013059	denotes	PGC-1α
T29841	53831-53835	NCBITaxon:10088	denotes	mice
T29842	53886-53893	UBERON:0002107	denotes	hepatic
T29843	53938-53943	NCBITaxon:10088	denotes	mouse
T29844	53980-53990	UBERON:0001016	denotes	neurologic
T29845	54054-54060	PR:000013059	denotes	PGC-1α
T29846	54064-54068	NCBITaxon:10088	denotes	mice
T29847	54097-54106	GO:0040011	denotes	locomotor
T29848	54341-54348	NCBITaxon:33208	denotes	animals
T29849	54413-54421	UBERON:0004288	denotes	skeletal
T29850	54433-54440	UBERON:0000948	denotes	cardiac
T29851	54641-54647	PR:000013059	denotes	PGC-1α
T29852	54658-54663	NCBITaxon:10088	denotes	mouse
T29853	54714-54721	SO:0000704	denotes	genetic
T29854	54866-54871	GO:0007567	denotes	natal
T29855	54895-54901	PR:000013059	denotes	PGC-1α
T29856	54905-54909	NCBITaxon:10088	denotes	mice
T29857	55024-55029	UBERON:0002107	denotes	liver
T29858	55040-55047	UBERON:0000479	denotes	tissues
T29859	55111-55115	SO:0000704	denotes	gene
T29860	55176-55182	PR:000013059	denotes	PGC-1α
T29861	55186-55190	NCBITaxon:10088	denotes	mice
T29862	55231-55236	SO:0000147	denotes	exons
T29863	55244-55251	CL:0000023	denotes	oocytes
T29864	55257-55263	PR:000013059	denotes	PGC-1α
T29865	55267-55271	NCBITaxon:10088	denotes	mice
T29866	55398-55414	SO:0001644	denotes	targeting vector
T29867	55434-55438	SO:0000147	denotes	exon
T29868	55449-55454	SO:0000147	denotes	exons
T33992	57589-57595	PR:000013059	denotes	PGC-1α
T33993	57596-57600	SO:0000704	denotes	gene
T33994	57604-57608	NCBITaxon:10088	denotes	mice
T33995	57611-57614	SO:0000153	denotes	BAC
T33996	57615-57628	SO:0000040	denotes	genomic clone
T33997	57644-57650	NCBITaxon:39107	denotes	murine
T33998	57651-57657	PR:000013059	denotes	PGC-1α
T33999	57658-57662	SO:0000704	denotes	gene
T34000	57687-57694	SO:0001026	denotes	genomic
T34001	57801-57805	SO:0000147	denotes	exon
T34002	57831-57844	SO:0000040	denotes	genomic clone
T34003	57848-57857	SO:0000121	denotes	5′ primer
T34004	57923-57925	SO:0000028	denotes	bp
T34005	57938-57942	SO:0000147	denotes	exon
T34006	57981-57997	SO:0000061	denotes	restriction site
T34007	58034-58043	SO:0000132	denotes	3′ primer
T34008	58056-58061	PR:P23940	denotes	BamH1
T34009	58185-58189	SO:0000147	denotes	exon
T34010	58277-58279	_FRAGMENT	denotes	5′
T34011	58287-58294	SO:0000121	denotes	primers
T34012	58284-58294	SO:0000132	denotes	3′ primers
T34013	58426-58442	SO:0001644	denotes	targeting vector
T34014	58511-58519	CL:0002322	denotes	ES cells
T34015	58542-58546	CHEBI:42768	denotes	G418
T34016	58621-58628	CL:0002322	denotes	ES Cell
T34017	58960-58970	UBERON:0000358	denotes	blastocyst
T34018	58986-58991	GO:0007618	denotes	mated
T34019	59004-59008	NCBITaxon:10088	denotes	mice
T34020	59073-59077	UBERON:0002415	denotes	tail
T35332	59199-59205	NCBITaxon:33208	denotes	animal
T35333	59218-59224	NCBITaxon:33208	denotes	animal
T35334	59372-59379	NCBITaxon:33208	denotes	animals
T35335	59418-59424	NCBITaxon:33208	denotes	Animal
T35336	59466-59473	NCBITaxon:33208	denotes	Animals
T35337	59544-59550	PR:000013059	denotes	PGC-1α
T35338	59558-59564	PR:000013059	denotes	PGC-1α
T35339	59568-59572	NCBITaxon:10088	denotes	mice
T35340	59594-59601	UBERON:0000479	denotes	tissues
T35341	59655-59661	UBERON:0000479	denotes	Tissue
T35342	59857-59863	PR:000013059	denotes	PGC-1α
T35343	59871-59877	PR:000013059	denotes	PGC-1α
T35344	59881-59885	NCBITaxon:10088	denotes	mice
T35345	59934-59940	PR:000013059	denotes	PGC-1α
T35346	59948-59954	PR:000013059	denotes	PGC-1α
T35347	59958-59962	NCBITaxon:10088	denotes	mice
T35348	60017-60021	CHEBI:33290	denotes	food
T35349	60064-60070	UBERON:0001052	denotes	rectal
T35350	60116-60120	NCBITaxon:10088	denotes	Mice
T35351	60200-60204	NCBITaxon:10088	denotes	mice
T35352	60225-60232	UBERON:0000479	denotes	tissues
T35353	60296-60303	NCBITaxon:33208	denotes	animals
T35354	60333-60338	CHEBI:15377	denotes	water
T35355	60351-60355	CHEBI:33290	denotes	Food
T35356	60398-60405	UBERON:0000479	denotes	tissues
T35357	60466-60470	NCBITaxon:10088	denotes	mice
T35358	60697-60703	NCBITaxon:33208	denotes	Animal
T35359	60809-60813	NCBITaxon:10088	denotes	mice
T36690	61193-61199	PR:000013060	denotes	PGC-1β
T36691	61204-61207	PR:000013159	denotes	PRC
T36692	61297-61302	PR:000017035	denotes	UCP-1
T36693	61415-61428	UBERON:0001389	denotes	soleus muscle
T36694	61430-61433	UBERON:0001348	denotes	BAT
T36695	61439-61444	UBERON:0000948	denotes	heart
T36696	61459-61465	PR:000013059	denotes	PGC-1α
T36697	61472-61476	PR:000013059	denotes	PGCα
T36698	61480-61484	NCBITaxon:10088	denotes	mice
T36699	61489-61508	GO:0001171	denotes	reverse transcribed
T36700	61521-61542	GO:0001171	denotes	reverse transcription
T36701	61543-61551	CHEBI:33893	denotes	reagents
T36702	61689-61697	CHEBI:33893	denotes	reagents
T36703	61759-61764	NCBITaxon:10088	denotes	mouse
T36704	61774-61780	SO:0000112	denotes	primer
T36705	61816-61820	SO:0000704	denotes	gene
T36706	61816-61831	GO:0010467	denotes	gene expression
T36707	61862-61869	SO:0000112	denotes	primers
T36708	61874-61879	PR:000017035	denotes	UCP-1
T36709	61923-61929	SO:0000112	denotes	primer
T36710	62019-62025	UBERON:0001389	denotes	soleus
T36711	62027-62030	UBERON:0001348	denotes	BAT
T36712	62036-62041	UBERON:0000948	denotes	heart
T36713	62042-62046	SO:0000704	denotes	gene
T36714	62042-62057	GO:0010467	denotes	gene expression
T36715	62070-62076	NCBITaxon:9989	denotes	Rodent
T36716	62077-62084	SO:0000112	denotes	primers
T36717	62150-62155	UBERON:0002107	denotes	liver
T36718	62156-62160	SO:0000704	denotes	gene
T36719	62156-62171	GO:0010467	denotes	gene expression
T36720	62213-62220	SO:0001026	denotes	genomic
T36721	62312-62316	SO:0000704	denotes	Gene
T36722	62390-62403	GO:0097617	denotes	hybridization
T38109	62680-62693	GO:0005739	denotes	Mitochondrial
T38110	62694-62705	GO:0045333	denotes	respiration
T38111	62714-62727	GO:0005739	denotes	Mitochondrial
T38112	62728-62739	GO:0045333	denotes	respiration
T38113	62756-62763	CHEBI:26605	denotes	saponin
T38114	62772-62778	UBERON:0001389	denotes	soleus
T38115	62837-62845	CHEBI:28201	denotes	rotenone
T38116	62902-62906	NCBITaxon:10088	denotes	mice
T38117	62930-62945	CHEBI:28142	denotes	chloral hydrate
T38118	62974-62980	UBERON:0001389	denotes	Soleus
T38119	63080-63085	CHEBI:6636	denotes	MgCl2
T38120	63093-63102	CHEBI:14434	denotes	imidazole
T38121	63114-63117	CHEBI:39010	denotes	MES
T38122	63125-63132	CHEBI:15891	denotes	taurine
T38123	63152-63155	CHEBI:17287	denotes	PCr
T38124	63162-63168	CHEBI:63036	denotes	KH2PO4
T38125	63177-63180	CHEBI:18320	denotes	DTT
T38126	63218-63225	CHEBI:26605	denotes	saponin
T38127	63375-63380	CHEBI:6636	denotes	MgCl2
T38128	63388-63397	CHEBI:14434	denotes	imidazole
T38129	63408-63411	CHEBI:39010	denotes	MES
T38130	63419-63426	CHEBI:15891	denotes	taurine
T38131	63433-63439	CHEBI:63036	denotes	KH2PO4
T38132	63448-63451	CHEBI:18320	denotes	DTT
T38133	63476-63487	GO:0045333	denotes	Respiration
T38134	63640-63651	GO:0045333	denotes	respiration
T38135	63686-63697	GO:0045333	denotes	respiration
T38136	63766-63794	GO:0005741	denotes	outer mitochondrial membrane
T38137	63833-63845	PR:000002199	denotes	cytochrome c
T38138	63833-63845	CHEBI:18070	denotes	cytochrome c
T38139	63880-63891	GO:0045333	denotes	respiration
T38140	63940-63950	CHEBI:25675	denotes	oligomycin
T38141	63994-64005	GO:0045333	denotes	respiration
T38142	64047-64049	CHEBI:15379	denotes	O2
T38143	64058-64069	GO:0045333	denotes	Respiration
T38144	64099-64101	CHEBI:15379	denotes	O2
T38913	64133-64140	CHEBI:17234	denotes	glucose
T38914	64157-64164	CHEBI:17234	denotes	Glucose
T38915	64169-64176	PR:000045358	denotes	Insulin
T38916	64245-64249	NCBITaxon:10088	denotes	mice
T38917	64308-64312	NCBITaxon:10088	denotes	mice
T38918	64338-64346	CHEBI:75958	denotes	solution
T38919	64350-64359	CHEBI:17634	denotes	D-glucose
T38920	64379-64383	NCBITaxon:10088	denotes	mice
T38921	64412-64417	NCBITaxon:9606	denotes	human
T38922	64412-64417	_FRAGMENT	denotes	human
T38923	64426-64433	CHEBI:5931	denotes	insulin
T38924	64426-64433	PR:000045358	denotes	insulin
T38925	64527-64531	UBERON:0002415	denotes	Tail
T38926	64538-64545	CHEBI:17234	denotes	glucose
T38927	64613-64620	CHEBI:17234	denotes	GLUCOSE
T39310	64735-64739	NCBITaxon:10088	denotes	mice
T39985	65153-65161	CHEBI:10545	denotes	electron
T39986	65173-65186	UBERON:0001389	denotes	Soleus muscle
T39987	65191-65196	UBERON:0002107	denotes	liver
T39988	65238-65252	CHEBI:64276	denotes	glutaraldehyde
T39989	65285-65302	CHEBI:62956	denotes	sodium cacodylate
T39990	65315-65322	UBERON:0000479	denotes	tissues
T39991	65383-65390	CHEBI:16236	denotes	ethanol
T39992	65446-65454	CHEBI:10545	denotes	electron
T39993	65467-65474	_FRAGMENT	denotes	Cardiac
T39994	65488-65494	UBERON:0001133	denotes	muscle
T39995	65479-65487	UBERON:0004288	denotes	skeletal
T39996	65495-65508	GO:0005739	denotes	mitochondrial
T39997	65513-65525	GO:0030016	denotes	myofibrillar
T39998	65564-65572	CHEBI:10545	denotes	electron
T39999	65624-65630	NCBITaxon:33208	denotes	animal
T40000	65767-65779	GO:0005739	denotes	mitochondria
T40001	65783-65793	GO:0030016	denotes	myofibrils
T40002	65813-65821	CHEBI:10545	denotes	electron
T40003	65850-65855	UBERON:0000955	denotes	brain
T40004	65857-65863	UBERON:0000479	denotes	tissue
T40005	65929-65935	UBERON:0001851	denotes	cortex
T40006	66051-66059	CHEBI:10545	denotes	electron
T40007	66076-66077	CHEBI:51686	denotes	H
T40008	66102-66107	UBERON:0000955	denotes	brain
T40009	66119-66134	UBERON:0000956	denotes	cerebral cortex
T40010	66136-66145	UBERON:0002298	denotes	brainstem
T40011	66151-66161	UBERON:0002037	denotes	cerebellum
T40012	66207-66214	CHEBI:30879	denotes	alcohol
T40699	66289-66294	NCBITaxon:10088	denotes	mouse
T40700	66295-66305	CL:0000182	denotes	hepatocyte
T40701	66334-66339	NCBITaxon:10088	denotes	mouse
T40702	66340-66351	CL:0000182	denotes	hepatocytes
T40703	66376-66382	PR:000013059	denotes	PGC-1α
T40704	66390-66396	PR:000013059	denotes	PGC-1α
T40705	66400-66404	NCBITaxon:10088	denotes	mice
T40706	66436-66446	CHEBI:35366	denotes	Fatty acid
T40707	66436-66456	GO:0019395	denotes	Fatty acid oxidation
T40708	66447-66456	MOP:0000568	denotes	oxidation
T40709	66461-66473	CHEBI:17855	denotes	triglyceride
T40710	66461-66483	GO:0019432	denotes	triglyceride synthesis
T40711	66546-66558	CHEBI:17855	denotes	Triglyceride
T40712	66546-66568	GO:0019432	denotes	Triglyceride synthesis
T40713	66623-66632	CHEBI:7896	denotes	Palmitate
T40714	66633-66642	MOP:0000568	denotes	oxidation
T40715	66677-66679	CHEBI:29238	denotes	3H
T40716	66681-66694	CHEBI:15756	denotes	palmitic acid
T40717	66767-66778	GO:0045333	denotes	respiration
T40718	66909-66916	CHEBI:26605	denotes	saponin
T40719	66918-66929	GO:0045333	denotes	Respiration
T40720	67012-67020	CHEBI:28201	denotes	rotenone
T40721	67022-67033	GO:0045333	denotes	Respiration
T40722	67063-67065	CHEBI:15379	denotes	O2
T42792	67108-67117	GO:0040011	denotes	locomotor
T42793	67128-67140	UBERON:0025534	denotes	sensorimotor
T42794	67227-67231	NCBITaxon:10088	denotes	mice
T42795	67939-67950	GO:0040011	denotes	ambulations
T42796	68141-68152	GO:0040011	denotes	ambulations
T42797	68211-68215	NCBITaxon:10088	denotes	mice
T42798	68348-68354	NCBITaxon:33208	denotes	animal
T42799	68395-68407	UBERON:0025534	denotes	sensorimotor
T42800	68557-68562	NCBITaxon:10088	denotes	mouse
T42801	68696-68702	NCBITaxon:33208	denotes	animal
T42802	68751-68755	UBERON:0000033	denotes	head
T42803	68909-68913	NCBITaxon:10088	denotes	mice
T42804	69017-69023	NCBITaxon:33208	denotes	animal
T42805	69062-69067	NCBITaxon:10088	denotes	mouse
T42806	69243-69248	NCBITaxon:10088	denotes	mouse
T42807	69418-69423	NCBITaxon:10088	denotes	mouse
T42808	69584-69589	NCBITaxon:10088	denotes	mouse
T42809	69753-69758	NCBITaxon:10088	denotes	mouse
T42810	69910-69915	NCBITaxon:10088	denotes	mouse
T42811	70038-70044	PR:000013059	denotes	PGC-1α
T42812	70060-70066	PR:000013059	denotes	PGC-1α
T42813	70078-70082	NCBITaxon:10088	denotes	mice
T44004	70410-70414	NCBITaxon:10088	denotes	mice
T44005	70609-70616	NCBITaxon:33208	denotes	Animals
T44006	70638-70647	GO:0008152	denotes	metabolic
T44007	70704-70708	NCBITaxon:10088	denotes	Mice
T44008	70879-70886	NCBITaxon:33208	denotes	animals
T44009	71017-71022	NCBITaxon:10088	denotes	mouse
T44010	71126-71132	NCBITaxon:33208	denotes	animal
T44011	71135-71137	CHEBI:15379	denotes	O2
T44778	71206-71213	NCBITaxon:33208	denotes	Animals
T44779	71237-71245	CHEBI:6121	denotes	ketamine
T44780	71263-71276	UBERON:0001389	denotes	soleus muscle
T44781	71298-71301	UBERON:0000978	denotes	leg
T44782	71353-71361	CHEBI:75958	denotes	solution
T44783	71379-71381	CHEBI:15379	denotes	O2
T44784	71389-71392	CHEBI:16526	denotes	CO2
T44785	71415-71423	CHEBI:75958	denotes	solution
T44786	71448-71453	CHEBI:15377	denotes	water
T44787	71632-71640	GO:0006936	denotes	contract
T45208	72363-72368	UBERON:0007023	denotes	Adult
T45209	72376-72380	NCBITaxon:10088	denotes	mice
T45210	72586-72591	NCBITaxon:10088	denotes	mouse
T45703	72730-72737	UBERON:0000948	denotes	cardiac
T45704	72857-72862	UBERON:0007023	denotes	adult
T45705	72863-72867	NCBITaxon:10088	denotes	mice
T45706	72902-72914	UBERON:0001179	denotes	peritoneally
T45707	72925-72942	CHEBI:9561	denotes	thiopental sodium
T45708	72959-72963	NCBITaxon:10088	denotes	mice
T45709	73031-73045	UBERON:0005396	denotes	carotid artery
T45710	73080-73087	UBERON:0003126	denotes	trachea
T45711	73240-73254	UBERON:0002084	denotes	left ventricle
T45712	73277-73289	UBERON:0002137	denotes	aortic valve
T45713	73406-73416	CHEBI:4670	denotes	dobutamine
T45714	73433-73451	CHEBI:37886	denotes	adrenergic agonist
T46687	73678-73683	NCBITaxon:10088	denotes	mouse
T46688	73684-73689	UBERON:0000948	denotes	heart
T46689	73717-73722	NCBITaxon:10088	denotes	mouse
T46690	73723-73728	UBERON:0000948	denotes	heart
T46691	73791-73796	UBERON:0007023	denotes	Adult
T46692	73797-73801	NCBITaxon:10088	denotes	mice
T46693	73875-73882	NCBITaxon:33208	denotes	Animals
T46694	73929-73949	CHEBI:7984	denotes	sodium pentobarbital
T46695	73954-73960	UBERON:0000948	denotes	Hearts
T46696	74016-74027	CHEBI:17544	denotes	bicarbonate
T46697	74034-74042	CHEBI:75958	denotes	solution
T46698	74051-74055	CHEBI:26710	denotes	NaCl
T46699	74063-74069	CHEBI:32139	denotes	NaHCO3
T46700	74078-74081	CHEBI:32588	denotes	KCl
T46701	74090-74096	CHEBI:63036	denotes	KH2PO4
T46702	74105-74110	CHEBI:3312	denotes	CaCl2
T46703	74119-74126	CHEBI:17234	denotes	glucose
T46704	74144-74151	PR:000045358	denotes	insulin
T46705	74163-74169	UBERON:0000948	denotes	Hearts
T46706	74200-74205	UBERON:0000947	denotes	aorta
T46707	74269-74280	UBERON:0002079	denotes	left atrial
T46708	74346-74354	CHEBI:75958	denotes	solution
T46709	74373-74382	CHEBI:7896	denotes	palmitate
T46710	74395-74405	CHEBI:35366	denotes	fatty acid
T46711	74525-74533	CHEBI:75958	denotes	solution
T46712	74567-74574	UBERON:0000948	denotes	cardiac
T46713	74583-74589	UBERON:0000947	denotes	aortic
T46714	74625-74630	UBERON:0000948	denotes	heart
T46715	74909-74916	UBERON:0000948	denotes	Cardiac
T46716	74982-74989	UBERON:0000948	denotes	cardiac
T47477	75087-75099	UBERON:0025534	denotes	sensorimotor
T47478	75271-75283	UBERON:0025534	denotes	sensorimotor
T29883	56384-56390	PR:000013059	denotes	PGC-1α
T29884	56428-56433	NCBITaxon:10088	denotes	mouse
T29885	56541-56547	PR:000013059	denotes	PGC-lα
T29886	56568-56586	GO:0051866	denotes	adaptive responses
T29887	56609-56614	GO:0007567	denotes	natal
T29888	56722-56728	PR:000013059	denotes	PGC-1α
T29889	56832-56842	_FRAGMENT	denotes	control of
T29890	56850-56860	GO:0019222	denotes	metabolism
T29891	56879-56897	GO:0050794	denotes	cellular processes
T29892	56941-56947	PR:000013059	denotes	PGC-1α
T29893	57024-57033	GO:0008152	denotes	metabolic
T29894	57056-57065	GO:0008152	denotes	metabolic
T29895	57085-57090	GO:0007567	denotes	natal
T29896	57116-57122	PR:000013059	denotes	PGC-1α
T29897	57128-57132	NCBITaxon:10088	denotes	mice
T29898	57264-57270	PR:000013059	denotes	PGC-1α
T29899	57332-57338	PR:000013059	denotes	PGC-1α
T29900	57342-57346	NCBITaxon:10088	denotes	mice
T29901	57372-57378	NCBITaxon:39107	denotes	murine
T29902	57427-57437	GO:0008152	denotes	metabolism
T29903	57460-57467	UBERON:0002107	denotes	hepatic
T29904	57499-57504	UBERON:0000948	denotes	heart
T29905	57506-57514	UBERON:0004288	denotes	skeletal
T29906	57527-57549	UBERON:0001017	denotes	central nervous system
T29870	55537-55547	SO:0000673	denotes	transcript
T29871	55614-55624	SO:0000673	denotes	transcript
T29872	55639-55643	_FRAGMENT	denotes	exon
T29873	55648-55654	SO:0000333	denotes	border
T29874	55769-55775	PR:000013059	denotes	PGC-1α
T38912	64121-64128	PR:000045358	denotes	Insulin
T29875	55960-55966	PR:000013059	denotes	PGC-1α
T29876	56034-56041	GO:0005634	denotes	nuclear
T29877	56063-56070	SO:0000417	denotes	domains
T29878	56105-56111	SO:0000417	denotes	domain
T29879	56133-56139	PR:000013059	denotes	PGC-1α
T29869	55468-55472	SO:0000147	denotes	exon
T29880	56168-56172	NCBITaxon:10088	denotes	mice
T29881	56331-56337	PR:000013059	denotes	PGC-1α
T29882	56341-56345	NCBITaxon:10088	denotes	mice
R302	T3156	T3155	_lexicallyChainedTo	genes,nuclear
R303	T3163	T3162	_lexicallyChainedTo	coactivator-1α,peroxisome proliferator-activated receptor-γ
R304	T3163	T3164	_lexicallyChainedTo	coactivator-1α,PPARγ
R305	T3168	T3167	_lexicallyChainedTo	metabolism,control of cellular
R306	T3182	T3181	_lexicallyChainedTo	metabolism,cellular
R307	T3188	T3187	_lexicallyChainedTo	production,ATP
R1109	T5523	T5522	_lexicallyChainedTo	transcript,region of
R1110	T5527	T5526	_lexicallyChainedTo	border,exon
R1111	T5531	T5530	_lexicallyChainedTo	border,exon
R1112	T5543	T5542	_lexicallyChainedTo	border,exon
R5708	T23946	T23945	_lexicallyChainedTo	cell neurons,Purkinje
R8685	T34011	T34010	_lexicallyChainedTo	primers,5′
R9986	T38923	T38922	_lexicallyChainedTo	insulin,human
R10198	T39994	T39993	_lexicallyChainedTo	muscle,Cardiac
R1	T632	T631	_lexicallyChainedTo	stressors,adaptation to
R308	T3203	T3202	_lexicallyChainedTo	metabolism,control of
R309	T3232	T3231	_lexicallyChainedTo	replication,mitochondrial DNA
R311	T3246	T3245	_lexicallyChainedTo	muscle fibers,formation of
R312	T3249	T3248	_lexicallyChainedTo	muscle fibers,type I
R313	T3252	T3251	_lexicallyChainedTo	muscle fibers,oxidative
R314	T3254	T3253	_lexicallyChainedTo	muscle fibers,slow-twitch
R316	T3260	T3259	_lexicallyChainedTo	metabolism,control of
R6078	T29654	T29653	_lexicallyChainedTo	metabolism,control of
R6079	T29591	T29590	_lexicallyChainedTo	metabolism,cellular
R6080	T29787	T29786	_lexicallyChainedTo	nervous system,peripheral
R6081	T29814	T29813	_lexicallyChainedTo	δ,CCAAT-enhancer-binding protein
R6082	T29766	T29765	_lexicallyChainedTo	cerebral cortex,neurons of
R6084	T29873	T29872	_lexicallyChainedTo	border,exon
R6085	T29890	T29889	_lexicallyChainedTo	metabolism,control of
R6086	T29891	T29889	_lexicallyChainedTo	cellular processes,control of

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