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2_test

{"project":"2_test","denotations":[{"id":"15841272-15234774-29500840","span":{"begin":1569,"end":1571},"obj":"15234774"}],"text":"Example of I, E and O Increase by Providing Panax ginseng\nPanax active principles are bonded to beta-adrenoceptors in the cellular membrane (Fig 4). This triggrers a secondary transmitting message system (cyclic AMP), the signal travels through a transducer pathway to the mitochondria to increase activity of MDH, SDH and CTS, enzymes of the glycolysis or tricarboxylic acid cycle. ATP generation is thus increased, raising energy levels using glucose as fuel, as shown in Figure 5. Moreover ginsenosides, such as the sulfonylureas, are insulin secretagogues (I stimulators) since they help regulate blood glucose levels by directly stimulating first-phase insulin secretion in the pancreatic beta cells (O). These cells are responsible for sensing and secreting appropriate amounts of insulin in response to a glucose stimulus. Mitochondrial glucose metabolism leads to ATP generation and increases intracellular ratios of ATP/ADP, which result in closure of the ATP-sensitive potassium channel (KATP; a 140 kDa membrane protein) on the plasma membrane. Closure of this channel depolarizes the membrane and triggers opening of voltage-sensitive calcium channels, leading to the rapid influx of calcium. Increased intracellular calcium causes an alteration in the cytoskeleton and stimulates translocation of insulin-containing secretor granules to the plasma membrane and the exocytotic release of insulin. Either an increase in the ATP/ADP ratio or binding of ginsenosides to cell membrane receptors results in the closure of the KATP channel and insulin secretion (21). This is depicted in Figure 6. As a corollary, with increasing energy we obtain a significantly larger health triangle because the system's intelligence has acquired more capacity to organize. Panax ginseng provides an example of a phytomedicine capable of enhancing I, E and O simultaneously in the living system."}

MyTest

{"project":"MyTest","denotations":[{"id":"15841272-15234774-29500840","span":{"begin":1569,"end":1571},"obj":"15234774"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Example of I, E and O Increase by Providing Panax ginseng\nPanax active principles are bonded to beta-adrenoceptors in the cellular membrane (Fig 4). This triggrers a secondary transmitting message system (cyclic AMP), the signal travels through a transducer pathway to the mitochondria to increase activity of MDH, SDH and CTS, enzymes of the glycolysis or tricarboxylic acid cycle. ATP generation is thus increased, raising energy levels using glucose as fuel, as shown in Figure 5. Moreover ginsenosides, such as the sulfonylureas, are insulin secretagogues (I stimulators) since they help regulate blood glucose levels by directly stimulating first-phase insulin secretion in the pancreatic beta cells (O). These cells are responsible for sensing and secreting appropriate amounts of insulin in response to a glucose stimulus. Mitochondrial glucose metabolism leads to ATP generation and increases intracellular ratios of ATP/ADP, which result in closure of the ATP-sensitive potassium channel (KATP; a 140 kDa membrane protein) on the plasma membrane. Closure of this channel depolarizes the membrane and triggers opening of voltage-sensitive calcium channels, leading to the rapid influx of calcium. Increased intracellular calcium causes an alteration in the cytoskeleton and stimulates translocation of insulin-containing secretor granules to the plasma membrane and the exocytotic release of insulin. Either an increase in the ATP/ADP ratio or binding of ginsenosides to cell membrane receptors results in the closure of the KATP channel and insulin secretion (21). This is depicted in Figure 6. As a corollary, with increasing energy we obtain a significantly larger health triangle because the system's intelligence has acquired more capacity to organize. Panax ginseng provides an example of a phytomedicine capable of enhancing I, E and O simultaneously in the living system."}

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MyTest

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PMC:1062161 / 11073-12960 JSON TXT