PMC:101403 / 1520-2269 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/101403","sourcedb":"PMC","sourceid":"101403","source_url":"https://www.ncbi.nlm.nih.gov/pmc/101403","text":"The Nudix hydrolase family comprises enzymes that hydrolyse predominantly the diphosphate (pyrophosphate) linkage in a variety of nucleoside triphosphates, dinucleoside polyphosphates, nucleotide sugars and nucleotide cofactors having the general structure of a nucleoside diphosphate linked to another moiety, X [1,2]. They are found in archaea, eubacteria, animal, plants, and fungi and all possess the Nudix box sequence signature motif Gx5Ex5 [UA]xREx2EExGU (where U is an aliphatic hydrophobic amino acid) [1,3]. The proposed functions of this family are to eliminate potentially toxic nucleotide metabolites from the cell and to regulate the concentrations of nucleotide cofactors and signalling molecules for optimal cell growth and survival.","tracks":[{"project":"2_test","denotations":[{"id":"11943069-8810257-8112308","span":{"begin":314,"end":315},"obj":"8810257"},{"id":"11943069-10373642-8112309","span":{"begin":316,"end":317},"obj":"10373642"},{"id":"11943069-8810257-8112310","span":{"begin":512,"end":513},"obj":"8810257"},{"id":"11943069-8233837-8112311","span":{"begin":514,"end":515},"obj":"8233837"}],"attributes":[{"subj":"11943069-8810257-8112308","pred":"source","obj":"2_test"},{"subj":"11943069-10373642-8112309","pred":"source","obj":"2_test"},{"subj":"11943069-8810257-8112310","pred":"source","obj":"2_test"},{"subj":"11943069-8233837-8112311","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93c8ec","default":true}]}]}}