CORD-19:ba334a8f734285257878e0df4e64a6131818d0c6 / 68401-68920 JSONTXT

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T88","span":{"begin":0,"end":519},"obj":"Sentence"}],"text":"Besides the further development of robust in vitro polymerase assays, preferable also for the AV polymerase, several key questions remain to be answered, including (i) how do nidovirus RNA polymerases initiate RNA synthesis?; (ii) how do the ExoN and RdRp domains work together to promote polymerase fidelity?; (iii) what is the function of the conserved NiRAN domain? (iv) how is the switch from transcription to replication controlled at the molecular level?; and (v) what is the composition and structure of the RTC?"}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T329","span":{"begin":0,"end":519},"obj":"Sentence"},{"id":"T10064","span":{"begin":0,"end":519},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Besides the further development of robust in vitro polymerase assays, preferable also for the AV polymerase, several key questions remain to be answered, including (i) how do nidovirus RNA polymerases initiate RNA synthesis?; (ii) how do the ExoN and RdRp domains work together to promote polymerase fidelity?; (iii) what is the function of the conserved NiRAN domain? (iv) how is the switch from transcription to replication controlled at the molecular level?; and (v) what is the composition and structure of the RTC?"}

{"project":"Epistemic_Statements","denotations":[{"id":"T182","span":{"begin":0,"end":224},"obj":"Epistemic_statement"},{"id":"T183","span":{"begin":224,"end":309},"obj":"Epistemic_statement"},{"id":"T184","span":{"begin":369,"end":460},"obj":"Epistemic_statement"}],"text":"Besides the further development of robust in vitro polymerase assays, preferable also for the AV polymerase, several key questions remain to be answered, including (i) how do nidovirus RNA polymerases initiate RNA synthesis?; (ii) how do the ExoN and RdRp domains work together to promote polymerase fidelity?; (iii) what is the function of the conserved NiRAN domain? (iv) how is the switch from transcription to replication controlled at the molecular level?; and (v) what is the composition and structure of the RTC?"}