CORD-19:ba334a8f734285257878e0df4e64a6131818d0c6 / 17083-17583 JSONTXT

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T34","span":{"begin":451,"end":473},"obj":"Disease"},{"id":"T35","span":{"begin":460,"end":473},"obj":"Disease"},{"id":"T80298","span":{"begin":451,"end":473},"obj":"Disease"},{"id":"T75390","span":{"begin":460,"end":473},"obj":"Disease"}],"attributes":[{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005765"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0006858"},{"id":"A30963","pred":"mondo_id","subj":"T80298","obj":"http://purl.obolibrary.org/obo/MONDO_0005765"},{"id":"A46183","pred":"mondo_id","subj":"T75390","obj":"http://purl.obolibrary.org/obo/MONDO_0006858"}],"text":"In case of the former, a model could be reliably generated for its conserved RdRp domain, based on a careful alignment of amino acids 388-890 to known polymerase sequences (Xu et al., 2003) An analysis of the predicted CoV RdRp domain architecture using three models (Fig. 3B ) revealed a right-handed fold that consists of thumb, palm and fingers subdomains, similar to known crystal structures of RdRp domains or complete RNA polymerases (shown for foot and mouth disease virus (FMDV) in Fig. 3A )."}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T85","span":{"begin":0,"end":500},"obj":"Sentence"}],"text":"In case of the former, a model could be reliably generated for its conserved RdRp domain, based on a careful alignment of amino acids 388-890 to known polymerase sequences (Xu et al., 2003) An analysis of the predicted CoV RdRp domain architecture using three models (Fig. 3B ) revealed a right-handed fold that consists of thumb, palm and fingers subdomains, similar to known crystal structures of RdRp domains or complete RNA polymerases (shown for foot and mouth disease virus (FMDV) in Fig. 3A )."}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T85","span":{"begin":0,"end":500},"obj":"Sentence"},{"id":"T94678","span":{"begin":0,"end":500},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In case of the former, a model could be reliably generated for its conserved RdRp domain, based on a careful alignment of amino acids 388-890 to known polymerase sequences (Xu et al., 2003) An analysis of the predicted CoV RdRp domain architecture using three models (Fig. 3B ) revealed a right-handed fold that consists of thumb, palm and fingers subdomains, similar to known crystal structures of RdRp domains or complete RNA polymerases (shown for foot and mouth disease virus (FMDV) in Fig. 3A )."}

{"project":"Epistemic_Statements","denotations":[{"id":"T29","span":{"begin":0,"end":272},"obj":"Epistemic_statement"}],"text":"In case of the former, a model could be reliably generated for its conserved RdRp domain, based on a careful alignment of amino acids 388-890 to known polymerase sequences (Xu et al., 2003) An analysis of the predicted CoV RdRp domain architecture using three models (Fig. 3B ) revealed a right-handed fold that consists of thumb, palm and fingers subdomains, similar to known crystal structures of RdRp domains or complete RNA polymerases (shown for foot and mouth disease virus (FMDV) in Fig. 3A )."}

{"project":"CORD-19-PD-UBERON","denotations":[{"id":"T10","span":{"begin":324,"end":329},"obj":"Body_part"},{"id":"T11","span":{"begin":340,"end":347},"obj":"Body_part"},{"id":"T12","span":{"begin":451,"end":455},"obj":"Body_part"},{"id":"T13","span":{"begin":460,"end":465},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001463"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002389"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002387"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000165"}],"text":"In case of the former, a model could be reliably generated for its conserved RdRp domain, based on a careful alignment of amino acids 388-890 to known polymerase sequences (Xu et al., 2003) An analysis of the predicted CoV RdRp domain architecture using three models (Fig. 3B ) revealed a right-handed fold that consists of thumb, palm and fingers subdomains, similar to known crystal structures of RdRp domains or complete RNA polymerases (shown for foot and mouth disease virus (FMDV) in Fig. 3A )."}