CORD-19:932bcdd2f6c6d487386e8bf983e4874387771be1 / 261186-261593 JSONTXT

{"project":"Epistemic_Statements","denotations":[{"id":"T563","span":{"begin":0,"end":407},"obj":"Epistemic_statement"}],"text":"TGF-beta has been implicated in T regulatory cell (Treg) activity, and since Treg cells frequently express the CD4+CD25+ phenotype, our results are consistent with the hypothesis that Treg cells maintain autoreactive T cells in the anergic state, but these can be released from anergy by products of the innate immune system (e.g., CpG) which override regulatory mechanisms that maintain immune homeostasis."}

{"project":"CORD-19-PD-UBERON","denotations":[{"id":"T791","span":{"begin":311,"end":324},"obj":"Body_part"}],"attributes":[{"id":"A791","pred":"uberon_id","subj":"T791","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"TGF-beta has been implicated in T regulatory cell (Treg) activity, and since Treg cells frequently express the CD4+CD25+ phenotype, our results are consistent with the hypothesis that Treg cells maintain autoreactive T cells in the anergic state, but these can be released from anergy by products of the innate immune system (e.g., CpG) which override regulatory mechanisms that maintain immune homeostasis."}