CORD-19:40812d7b28ab3c043610f6e224b3f62806af6eb6 / 37090-38355 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/CORD-19/sourceid/40812d7b28ab3c043610f6e224b3f62806af6eb6","sourcedb":"CORD-19","sourceid":"40812d7b28ab3c043610f6e224b3f62806af6eb6","text":"Initially, sequence comparisons of neutralizing epitopes on the S protein suggested that the antigenic variations between classical and emerging non-S INDEL (highly virulent) PEDV strains are the major reason for vaccine failure (Table 3) . Several regions on PEDV S protein were recognized as containing the neutralizing epitopes, including a CO-26 K equivalent epitope COE (aa 499-638), SS2 (aa 748-755), SS6 (aa 764-771) and 2C10 (aa 1368-1374) (Chang et al., 2002; Ge et al., 2012; Kang et al., 2005; Oszvald et al., 2007) . Compared with classical PEDV vaccine strains, several SNPs leading to 8-11 individual amino acid changes located on COE epitope and 1-2 amino acid changes located on SS6 epitope were observed in highly virulent PEDV strains . Among them, three (A522S, A554 S and G599S) and one (Y766S) were serine substitutions (Table 3 ) (Chiou et al., 2015; Hao et al., 2014; Huang et al., 2013; . In addition, bioinformatics predicted that the S protein of highly virulent PEDV strains changed in primary/secondary structures, high-specificity N-glycosylation sites, potential phosphorylation sites, and palmitoylation sites (Chiou et al., 2015; Hao et al., 2014) . These changes may affect viral antigenicity and change viral neutralizing activity.","tracks":[{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T318","span":{"begin":0,"end":1265},"obj":"https://id.nlm.nih.gov/mesh/D014780"},{"id":"T319","span":{"begin":0,"end":1265},"obj":"https://www.uniprot.org/uniprot/P0DTC2"},{"id":"T320","span":{"begin":0,"end":1265},"obj":"http://purl.obolibrary.org/obo/GO0016310"},{"id":"T321","span":{"begin":0,"end":1265},"obj":"http://purl.obolibrary.org/obo/GO0070085"},{"id":"T322","span":{"begin":0,"end":1265},"obj":"http://purl.obolibrary.org/obo/GO0020033"}],"attributes":[{"id":"A318","pred":"class","subj":"T318","obj":"SPECIES"},{"id":"A319","pred":"class","subj":"T319","obj":"CVPROT"},{"id":"A320","pred":"class","subj":"T320","obj":"GOONTOL"},{"id":"A321","pred":"class","subj":"T321","obj":"GOONTOL"},{"id":"A322","pred":"class","subj":"T322","obj":"GOONTOL"},{"subj":"T318","pred":"source","obj":"CORD-19-SciBite-sentences"},{"subj":"T319","pred":"source","obj":"CORD-19-SciBite-sentences"},{"subj":"T320","pred":"source","obj":"CORD-19-SciBite-sentences"},{"subj":"T321","pred":"source","obj":"CORD-19-SciBite-sentences"},{"subj":"T322","pred":"source","obj":"CORD-19-SciBite-sentences"}]},{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T232","span":{"begin":0,"end":240},"obj":"Sentence"},{"id":"TextSentencer_T233","span":{"begin":241,"end":528},"obj":"Sentence"},{"id":"TextSentencer_T234","span":{"begin":529,"end":754},"obj":"Sentence"},{"id":"TextSentencer_T235","span":{"begin":755,"end":912},"obj":"Sentence"},{"id":"TextSentencer_T236","span":{"begin":913,"end":1181},"obj":"Sentence"},{"id":"TextSentencer_T237","span":{"begin":1182,"end":1265},"obj":"Sentence"},{"id":"TextSentencer_T232","span":{"begin":0,"end":240},"obj":"Sentence"},{"id":"TextSentencer_T233","span":{"begin":241,"end":528},"obj":"Sentence"},{"id":"TextSentencer_T234","span":{"begin":529,"end":754},"obj":"Sentence"},{"id":"TextSentencer_T235","span":{"begin":755,"end":912},"obj":"Sentence"},{"id":"TextSentencer_T236","span":{"begin":913,"end":1181},"obj":"Sentence"},{"id":"TextSentencer_T237","span":{"begin":1182,"end":1265},"obj":"Sentence"},{"id":"T55412","span":{"begin":0,"end":240},"obj":"Sentence"},{"id":"T1963","span":{"begin":241,"end":528},"obj":"Sentence"},{"id":"T92284","span":{"begin":529,"end":754},"obj":"Sentence"},{"id":"T10945","span":{"begin":755,"end":912},"obj":"Sentence"},{"id":"T83094","span":{"begin":913,"end":1181},"obj":"Sentence"},{"id":"T86398","span":{"begin":1182,"end":1265},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T232","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T233","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T234","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T235","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T236","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T237","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T232","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T233","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T234","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T235","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T236","pred":"source","obj":"CORD-19-Sentences"},{"subj":"TextSentencer_T237","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T55412","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T1963","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T92284","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T10945","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T83094","pred":"source","obj":"CORD-19-Sentences"},{"subj":"T86398","pred":"source","obj":"CORD-19-Sentences"}]},{"project":"Epistemic_Statements","denotations":[{"id":"T68","span":{"begin":0,"end":240},"obj":"Epistemic_statement"},{"id":"T69","span":{"begin":913,"end":1181},"obj":"Epistemic_statement"},{"id":"T70","span":{"begin":1182,"end":1265},"obj":"Epistemic_statement"}],"attributes":[{"subj":"T68","pred":"source","obj":"Epistemic_Statements"},{"subj":"T69","pred":"source","obj":"Epistemic_Statements"},{"subj":"T70","pred":"source","obj":"Epistemic_Statements"}]},{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T232","span":{"begin":0,"end":240},"obj":"Sentence"},{"id":"T233","span":{"begin":241,"end":528},"obj":"Sentence"},{"id":"T234","span":{"begin":529,"end":754},"obj":"Sentence"},{"id":"T235","span":{"begin":755,"end":912},"obj":"Sentence"},{"id":"T236","span":{"begin":913,"end":1181},"obj":"Sentence"},{"id":"T237","span":{"begin":1182,"end":1265},"obj":"Sentence"}],"attributes":[{"subj":"T232","pred":"source","obj":"CORD-19_Custom_license_subset"},{"subj":"T233","pred":"source","obj":"CORD-19_Custom_license_subset"},{"subj":"T234","pred":"source","obj":"CORD-19_Custom_license_subset"},{"subj":"T235","pred":"source","obj":"CORD-19_Custom_license_subset"},{"subj":"T236","pred":"source","obj":"CORD-19_Custom_license_subset"},{"subj":"T237","pred":"source","obj":"CORD-19_Custom_license_subset"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"CORD-19-SciBite-sentences","color":"#93c7ec","default":true},{"id":"CORD-19-Sentences","color":"#e1ec93"},{"id":"Epistemic_Statements","color":"#dd93ec"},{"id":"CORD-19_Custom_license_subset","color":"#93ecc3"}]}]}}