CORD-19:2008f024274c53b0de1276f4047a6a641813fd98 / 0-1703 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/CORD-19/sourceid/2008f024274c53b0de1276f4047a6a641813fd98","sourcedb":"CORD-19","sourceid":"2008f024274c53b0de1276f4047a6a641813fd98","text":"ABSTRACTS: CONCURRENT SESSIONS\n\nAbstract\n\n\nINTRODUCTION: The effect of anti IgE has been described as a function of complexing free IgE to reduce mast cell implantation and consequent reduction of mast cell degranulation upon exposure to antigen. Theoretically, as total free IgE drops below 10 ng/ml, improvement occurs as free and cell bound IgE equilibrate and allergic reactions subside. Initial observations ( Togias A et al. J Allergy Clin Immunol. 1998 ;101:S171)suggested that prick skin tests consistently reached their low point at 98 days with significant reduction in size. Laynadier (Leynadier F, Doudou O, Gaouar H, Le Gros V, Bourdeix I, Guyomarch-Cocco L, Trunet P : Effect of omalizumab in health care workers with occupational latex allergy.J Allergy Clin Immunol 2004;113:360-1) noted some reduction in skin testing in sixty percent of patients treated over a six month period with monoclonal antiIgE. But clinicians since approval of the drug in 2002 have noted that even in the presence of good clinical response to asthma, skin test reactivity is still obvious, and in many cases unchanged. METHODS: Following the suggestions for standard clinical follow up by Lanier and Marshall ( Annals May 2003) , routine skin prick skin testing was completed after informed consent on 24 patients at onset of anti-IgE therapy, and repeated at 6-7 months. In all instances were skin tests done and photographed in a standard manner. In a few cases, skin tests were repeated on patients receiving anti IgE for as long as five years. RESULTS: Photographic evidence will be presented. In 22 of 24 patients on current therapy, prick skin testing remained at an almost identical photographic level 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