CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 51374-52446 JSONTXT

{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T594","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0004620"},{"id":"T595","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0005886"},{"id":"T596","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0005622"},{"id":"T598","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0005783"},{"id":"T600","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0005576"},{"id":"T602","span":{"begin":0,"end":1072},"obj":"http://purl.obolibrary.org/obo/GO0032281"}],"attributes":[{"id":"A594","pred":"class","subj":"T594","obj":"GOONTOL"},{"id":"A595","pred":"class","subj":"T595","obj":"GOONTOL"},{"id":"A596","pred":"class","subj":"T596","obj":"GOONTOL"},{"id":"A598","pred":"class","subj":"T598","obj":"GOONTOL"},{"id":"A600","pred":"class","subj":"T600","obj":"GOONTOL"},{"id":"A602","pred":"class","subj":"T602","obj":"GOONTOL"}],"text":"In contrast, the delayed type response was pre-vented by removal and chelation of extracellular Ca 2+ . Moreover, although the number of cells exhibiting an immediate response to treatment with the O4 monoclonal IgM was not affected by blocking several classes of plasma membrane Ca 2+ channels, pharmacologically blocking the activity of phospholipase C (PLC) significantly decreased the percentage of astrocytes that exhibited elevated intracellular Ca 2+ . In contrast, the delayed Ca 2+ response in oligodendrocytes was not dependent on intracellular stores, but was sensitive to pharmacological inhibition of Ca 2+ flux through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate channels . These data support the conclusion that the delayed response in oligodendrocytes is dependent on Ca 2+ entry through AMPA receptor Ca 2+ channels, whereas the immediate response in astrocytes is dependent on Ca 2+ release from endoplasmic reticulum stores, likely through PLC-mediated generation of IP 3 and gating of IP 3sensitive calcium channels."}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T17","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T18","span":{"begin":104,"end":459},"obj":"Sentence"},{"id":"T19","span":{"begin":460,"end":723},"obj":"Sentence"},{"id":"T20","span":{"begin":724,"end":1072},"obj":"Sentence"}],"text":"In contrast, the delayed type response was pre-vented by removal and chelation of extracellular Ca 2+ . Moreover, although the number of cells exhibiting an immediate response to treatment with the O4 monoclonal IgM was not affected by blocking several classes of plasma membrane Ca 2+ channels, pharmacologically blocking the activity of phospholipase C (PLC) significantly decreased the percentage of astrocytes that exhibited elevated intracellular Ca 2+ . In contrast, the delayed Ca 2+ response in oligodendrocytes was not dependent on intracellular stores, but was sensitive to pharmacological inhibition of Ca 2+ flux through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate channels . These data support the conclusion that the delayed response in oligodendrocytes is dependent on Ca 2+ entry through AMPA receptor Ca 2+ channels, whereas the immediate response in astrocytes is dependent on Ca 2+ release from endoplasmic reticulum stores, likely through PLC-mediated generation of IP 3 and gating of IP 3sensitive calcium channels."}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T259","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"TextSentencer_T260","span":{"begin":104,"end":459},"obj":"Sentence"},{"id":"TextSentencer_T261","span":{"begin":460,"end":723},"obj":"Sentence"},{"id":"TextSentencer_T262","span":{"begin":724,"end":1072},"obj":"Sentence"},{"id":"TextSentencer_T259","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"TextSentencer_T260","span":{"begin":104,"end":459},"obj":"Sentence"},{"id":"TextSentencer_T261","span":{"begin":460,"end":723},"obj":"Sentence"},{"id":"TextSentencer_T262","span":{"begin":724,"end":1072},"obj":"Sentence"},{"id":"T10703","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T90690","span":{"begin":104,"end":459},"obj":"Sentence"},{"id":"T90292","span":{"begin":460,"end":723},"obj":"Sentence"},{"id":"T85614","span":{"begin":724,"end":1072},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In contrast, the delayed type response was pre-vented by removal and chelation of extracellular Ca 2+ . Moreover, although the number of cells exhibiting an immediate response to treatment with the O4 monoclonal IgM was not affected by blocking several classes of plasma membrane Ca 2+ channels, pharmacologically blocking the activity of phospholipase C (PLC) significantly decreased the percentage of astrocytes that exhibited elevated intracellular Ca 2+ . In contrast, the delayed Ca 2+ response in oligodendrocytes was not dependent on intracellular stores, but was sensitive to pharmacological inhibition of Ca 2+ flux through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate channels . These data support the conclusion that the delayed response in oligodendrocytes is dependent on Ca 2+ entry through AMPA receptor Ca 2+ channels, whereas the immediate response in astrocytes is dependent on Ca 2+ release from endoplasmic reticulum stores, likely through PLC-mediated generation of IP 3 and gating of IP 3sensitive calcium channels."}

{"project":"Epistemic_Statements","denotations":[{"id":"T118","span":{"begin":104,"end":459},"obj":"Epistemic_statement"},{"id":"T119","span":{"begin":724,"end":1072},"obj":"Epistemic_statement"}],"text":"In contrast, the delayed type response was pre-vented by removal and chelation of extracellular Ca 2+ . Moreover, although the number of cells exhibiting an immediate response to treatment with the O4 monoclonal IgM was not affected by blocking several classes of plasma membrane Ca 2+ channels, pharmacologically blocking the activity of phospholipase C (PLC) significantly decreased the percentage of astrocytes that exhibited elevated intracellular Ca 2+ . In contrast, the delayed Ca 2+ response in oligodendrocytes was not dependent on intracellular stores, but was sensitive to pharmacological inhibition of Ca 2+ flux through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate channels . These data support the conclusion that the delayed response in oligodendrocytes is dependent on Ca 2+ entry through AMPA receptor Ca 2+ channels, whereas the immediate response in astrocytes is dependent on Ca 2+ release from endoplasmic reticulum stores, likely through PLC-mediated generation of IP 3 and gating of IP 3sensitive calcium channels."}

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T175","span":{"begin":39,"end":42},"obj":"Disease"},{"id":"T176","span":{"begin":216,"end":219},"obj":"Disease"},{"id":"T177","span":{"begin":520,"end":523},"obj":"Disease"},{"id":"T178","span":{"begin":567,"end":570},"obj":"Disease"}],"attributes":[{"id":"A175","pred":"mondo_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"},{"id":"A176","pred":"mondo_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"},{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"},{"id":"A178","pred":"mondo_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/MONDO_0010518"}],"text":"In contrast, the delayed type response was pre-vented by removal and chelation of extracellular Ca 2+ . Moreover, although the number of cells exhibiting an immediate response to treatment with the O4 monoclonal IgM was not affected by blocking several classes of plasma membrane Ca 2+ channels, pharmacologically blocking the activity of phospholipase C (PLC) significantly decreased the percentage of astrocytes that exhibited elevated intracellular Ca 2+ . In contrast, the delayed Ca 2+ response in oligodendrocytes was not dependent on intracellular stores, but was sensitive to pharmacological inhibition of Ca 2+ flux through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate channels . These data support the conclusion that the delayed response in oligodendrocytes is dependent on Ca 2+ entry through AMPA receptor Ca 2+ channels, whereas the immediate response in astrocytes is dependent on Ca 2+ release from endoplasmic reticulum stores, likely through PLC-mediated generation of IP 3 and gating of IP 3sensitive calcium channels."}