CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 35569-36402 JSONTXT

{"project":"CORD-19-SciBite-sentences","denotations":[{"id":"T473","span":{"begin":0,"end":833},"obj":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6"},{"id":"T474","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D017934"},{"id":"T475","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D017945"},{"id":"T476","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D051379"},{"id":"T477","span":{"begin":0,"end":833},"obj":"http://purl.obolibrary.org/obo/GO0043526"},{"id":"T478","span":{"begin":0,"end":833},"obj":"http://purl.obolibrary.org/obo/GO0031175"},{"id":"T479","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D016472"},{"id":"T480","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D014777"},{"id":"T481","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D017945"},{"id":"T482","span":{"begin":0,"end":833},"obj":"https://id.nlm.nih.gov/mesh/D007249"}],"attributes":[{"id":"A480","pred":"class","subj":"T480","obj":"INDICATION"},{"id":"A477","pred":"class","subj":"T477","obj":"GOONTOL"},{"id":"A478","pred":"class","subj":"T478","obj":"GOONTOL"},{"id":"A482","pred":"class","subj":"T482","obj":"INDICATION"},{"id":"A474","pred":"class","subj":"T474","obj":"SPECIES"},{"id":"A473","pred":"class","subj":"T473","obj":"GENE"},{"id":"A479","pred":"class","subj":"T479","obj":"INDICATION"},{"id":"A476","pred":"class","subj":"T476","obj":"SPECIES"},{"id":"A481","pred":"class","subj":"T481","obj":"INDICATION"},{"id":"A475","pred":"class","subj":"T475","obj":"SPECIES"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T180","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T181","span":{"begin":206,"end":456},"obj":"Sentence"},{"id":"T182","span":{"begin":457,"end":671},"obj":"Sentence"},{"id":"T183","span":{"begin":672,"end":833},"obj":"Sentence"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}

{"project":"CORD-19-Sentences","denotations":[{"id":"TextSentencer_T180","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"TextSentencer_T181","span":{"begin":206,"end":456},"obj":"Sentence"},{"id":"TextSentencer_T182","span":{"begin":457,"end":671},"obj":"Sentence"},{"id":"TextSentencer_T183","span":{"begin":672,"end":833},"obj":"Sentence"},{"id":"TextSentencer_T180","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"TextSentencer_T181","span":{"begin":206,"end":456},"obj":"Sentence"},{"id":"TextSentencer_T182","span":{"begin":457,"end":671},"obj":"Sentence"},{"id":"TextSentencer_T183","span":{"begin":672,"end":833},"obj":"Sentence"},{"id":"T46703","span":{"begin":0,"end":205},"obj":"Sentence"},{"id":"T96989","span":{"begin":206,"end":456},"obj":"Sentence"},{"id":"T17562","span":{"begin":457,"end":671},"obj":"Sentence"},{"id":"T19489","span":{"begin":672,"end":833},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}

{"project":"Epistemic_Statements","denotations":[{"id":"T82","span":{"begin":672,"end":833},"obj":"Epistemic_statement"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T130","span":{"begin":71,"end":74},"obj":"Disease"},{"id":"T131","span":{"begin":139,"end":154},"obj":"Disease"},{"id":"T132","span":{"begin":145,"end":154},"obj":"Disease"},{"id":"T133","span":{"begin":397,"end":417},"obj":"Disease"},{"id":"T134","span":{"begin":457,"end":466},"obj":"Disease"},{"id":"T135","span":{"begin":644,"end":659},"obj":"Disease"},{"id":"T136","span":{"begin":650,"end":659},"obj":"Disease"},{"id":"T137","span":{"begin":758,"end":770},"obj":"Disease"}],"attributes":[{"id":"A130","pred":"mondo_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/MONDO_0018816"},{"id":"A131","pred":"mondo_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0020128"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}

{"project":"CORD-19-PD-UBERON","denotations":[{"id":"T86","span":{"begin":46,"end":50},"obj":"Body_part"}],"attributes":[{"id":"A86","pred":"uberon_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/UBERON_0006967"}],"text":"Instead, we found that IL-6 protects anterior horn neurons, as well as NSC-34 motor neurons (Cashman et al., 1992) , from death induced by viral infection via a direct neuroprotective mechanism (Fig. 16) . This finding is in agreement with other reports that IL-6 promotes neurite outgrowth and survival of cultured enteric neurons (Schafer et al., 1999) , and that IL-6 delays the progression of motor neuron disease in wobbler mice (Ikeda et al., 1996) . Infection with a neurotropic coronavirus activated astrocytes to produce IL-6 (Sun et al., 1995) , and we observed a similar upregulation in astrocytic expression of IL-6 after Theiler's virus infection (Fig. 16) . Therefore, we suggest that IL-6, normally considered to be an immune modulator during inflammation, signals to protect motor neurons from death, potentially in a"}