CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 10899-11670 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/CORD-19/sourceid/16a812de72963ceda960a168236e8dbe91832d45","sourcedb":"CORD-19","sourceid":"16a812de72963ceda960a168236e8dbe91832d45","text":"Consistent with the genetics of resistance discussed previously, the cytotoxic T-cell response observed during the acute phase of Theiler's virus infection is restricted to the D b molecule . Moreover, after Theiler's virus infection of resistant mice of the H-2 b haplotype, we have identified an immunodominant cytotoxic T-cell population within the CNS that is specific for the VP2 121-130 viral capsid peptide presented within the context of D b (Johnson et al., 1999) . We have also previously demonstrated that cytotoxic T-cells appear to play a critical role in the injury of neurons and axons in both the acute (Howe and Rodriguez, unpublished observations) and chronic phases of Theiler's virus infection (Rivera-Quinones et al., 1998; Ure and Rodriguez, 2000; 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