CORD-19:12d35c12218f230c49f4dc892814ba9f1037f251 / 65966-66744 JSONTXT

{"project":"CORD-19_Custom_license_subset","denotations":[{"id":"T76","span":{"begin":0,"end":778},"obj":"Sentence"}],"text":"Viral specific T cells are subsequently selected through TCR/MHC I engagement and undergo rapid clonal expansion and differentiation. (3) Effector T cells migrate to the site of infection via the circulation where they receive survival signals, in the form of IL-15, from respiratory DCs (4) and through the release of anti-viral cytokines and effector molecules kill virus infected epithelial cells. (5) After viral clearance the majority of virus-specific effector CD8 T cells die through apoptosis, whilst a hand full of surviving effector CD8 T cells persist and seed a long-lived memory pool (6) comprised of central memory T cells (CD62L hi , CCR7 hi ), that reside in lymphoid tissue, and effector memory T cells (CD62L lo , CCR7 lo ) that reside at mucosal surfaces (7)."}

{"project":"CORD-19-Sentences","denotations":[{"id":"T88937","span":{"begin":0,"end":778},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Viral specific T cells are subsequently selected through TCR/MHC I engagement and undergo rapid clonal expansion and differentiation. (3) Effector T cells migrate to the site of infection via the circulation where they receive survival signals, in the form of IL-15, from respiratory DCs (4) and through the release of anti-viral cytokines and effector molecules kill virus infected epithelial cells. (5) After viral clearance the majority of virus-specific effector CD8 T cells die through apoptosis, whilst a hand full of surviving effector CD8 T cells persist and seed a long-lived memory pool (6) comprised of central memory T cells (CD62L hi , CCR7 hi ), that reside in lymphoid tissue, and effector memory T cells (CD62L lo , CCR7 lo ) that reside at mucosal surfaces (7)."}

{"project":"CORD-19-PD-UBERON","denotations":[{"id":"T95","span":{"begin":511,"end":515},"obj":"Body_part"},{"id":"T96","span":{"begin":675,"end":690},"obj":"Body_part"},{"id":"T97","span":{"begin":684,"end":690},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"uberon_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A96","pred":"uberon_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/UBERON_0001744"},{"id":"A97","pred":"uberon_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Viral specific T cells are subsequently selected through TCR/MHC I engagement and undergo rapid clonal expansion and differentiation. (3) Effector T cells migrate to the site of infection via the circulation where they receive survival signals, in the form of IL-15, from respiratory DCs (4) and through the release of anti-viral cytokines and effector molecules kill virus infected epithelial cells. (5) After viral clearance the majority of virus-specific effector CD8 T cells die through apoptosis, whilst a hand full of surviving effector CD8 T cells persist and seed a long-lived memory pool (6) comprised of central memory T cells (CD62L hi , CCR7 hi ), that reside in lymphoid tissue, and effector memory T cells (CD62L lo , CCR7 lo ) that reside at mucosal surfaces (7)."}

{"project":"CORD-19-PD-MONDO","denotations":[{"id":"T205","span":{"begin":178,"end":187},"obj":"Disease"},{"id":"T206","span":{"begin":644,"end":646},"obj":"Disease"},{"id":"T207","span":{"begin":654,"end":656},"obj":"Disease"},{"id":"T23217","span":{"begin":178,"end":187},"obj":"Disease"},{"id":"T12146","span":{"begin":644,"end":646},"obj":"Disease"},{"id":"T70958","span":{"begin":654,"end":656},"obj":"Disease"}],"attributes":[{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0009443"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0009443"},{"id":"A75508","pred":"mondo_id","subj":"T23217","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A77017","pred":"mondo_id","subj":"T12146","obj":"http://purl.obolibrary.org/obo/MONDO_0009443"},{"id":"A42285","pred":"mondo_id","subj":"T70958","obj":"http://purl.obolibrary.org/obo/MONDO_0009443"}],"text":"Viral specific T cells are subsequently selected through TCR/MHC I engagement and undergo rapid clonal expansion and differentiation. (3) Effector T cells migrate to the site of infection via the circulation where they receive survival signals, in the form of IL-15, from respiratory DCs (4) and through the release of anti-viral cytokines and effector molecules kill virus infected epithelial cells. (5) After viral clearance the majority of virus-specific effector CD8 T cells die through apoptosis, whilst a hand full of surviving effector CD8 T cells persist and seed a long-lived memory pool (6) comprised of central memory T cells (CD62L hi , CCR7 hi ), that reside in lymphoid tissue, and effector memory T cells (CD62L lo , CCR7 lo ) that reside at mucosal surfaces (7)."}