BB-rel@ldeleger:BB-rel-9745160 JSONTXT

{"project":"bionlp-ost-19-BB-rel-dev","denotations":[{"id":"T1","span":{"begin":0,"end":109},"obj":"Title"},{"id":"T7","span":{"begin":59,"end":73},"obj":"Habitat"},{"id":"T6","span":{"begin":59,"end":67},"obj":"Habitat"},{"id":"T8","span":{"begin":79,"end":98},"obj":"Microorganism"},{"id":"T2","span":{"begin":110,"end":656},"obj":"Paragraph"},{"id":"T9","span":{"begin":165,"end":179},"obj":"Habitat"},{"id":"T10","span":{"begin":165,"end":173},"obj":"Habitat"},{"id":"T11","span":{"begin":196,"end":215},"obj":"Microorganism"},{"id":"T12","span":{"begin":360,"end":375},"obj":"Phenotype"},{"id":"T13","span":{"begin":546,"end":553},"obj":"Habitat"},{"id":"T3","span":{"begin":657,"end":1547},"obj":"Paragraph"},{"id":"T14","span":{"begin":664,"end":730},"obj":"Habitat"},{"id":"T15","span":{"begin":685,"end":699},"obj":"Habitat"},{"id":"T16","span":{"begin":685,"end":693},"obj":"Habitat"},{"id":"T17","span":{"begin":712,"end":720},"obj":"Microorganism"},{"id":"T18","span":{"begin":783,"end":796},"obj":"Microorganism"},{"id":"T19","span":{"begin":1271,"end":1279},"obj":"Microorganism"},{"id":"T20","span":{"begin":1419,"end":1427},"obj":"Microorganism"},{"id":"T21","span":{"begin":1436,"end":1441},"obj":"Habitat"},{"id":"T22","span":{"begin":1488,"end":1496},"obj":"Habitat"},{"id":"T4","span":{"begin":1548,"end":2241},"obj":"Paragraph"},{"id":"T23","span":{"begin":1560,"end":1568},"obj":"Habitat"},{"id":"T24","span":{"begin":1627,"end":1635},"obj":"Microorganism"},{"id":"T25","span":{"begin":1651,"end":1659},"obj":"Microorganism"},{"id":"T26","span":{"begin":1776,"end":1781},"obj":"Habitat"},{"id":"T27","span":{"begin":1883,"end":1891},"obj":"Habitat"},{"id":"T28","span":{"begin":1985,"end":2023},"obj":"Habitat"},{"id":"T29","span":{"begin":2065,"end":2107},"obj":"Habitat"},{"id":"T30","span":{"begin":2232,"end":2240},"obj":"Habitat"},{"id":"T5","span":{"begin":2242,"end":2579},"obj":"Paragraph"},{"id":"T31","span":{"begin":2358,"end":2366},"obj":"Microorganism"},{"id":"T33","span":{"begin":2508,"end":2522},"obj":"Habitat"},{"id":"T32","span":{"begin":2508,"end":2516},"obj":"Habitat"},{"id":"T34","span":{"begin":2539,"end":2547},"obj":"Microorganism"},{"id":"E1","span":{"begin":79,"end":98},"obj":"Lives_In"},{"id":"E2","span":{"begin":79,"end":98},"obj":"Lives_In"},{"id":"E3","span":{"begin":196,"end":215},"obj":"Lives_In"},{"id":"E4","span":{"begin":196,"end":215},"obj":"Lives_In"},{"id":"E5","span":{"begin":712,"end":720},"obj":"Lives_In"},{"id":"E6","span":{"begin":712,"end":720},"obj":"Lives_In"},{"id":"E7","span":{"begin":712,"end":720},"obj":"Lives_In"},{"id":"E8","span":{"begin":2539,"end":2547},"obj":"Lives_In"},{"id":"E9","span":{"begin":2539,"end":2547},"obj":"Lives_In"}],"relations":[{"id":"R1","pred":"Microorganism","subj":"E1","obj":"T8"},{"id":"R2","pred":"Location","subj":"E1","obj":"T6"},{"id":"R3","pred":"Microorganism","subj":"E2","obj":"T8"},{"id":"R4","pred":"Location","subj":"E2","obj":"T7"},{"id":"R5","pred":"Microorganism","subj":"E3","obj":"T11"},{"id":"R6","pred":"Location","subj":"E3","obj":"T9"},{"id":"R7","pred":"Microorganism","subj":"E4","obj":"T11"},{"id":"R8","pred":"Location","subj":"E4","obj":"T10"},{"id":"R9","pred":"Microorganism","subj":"E5","obj":"T17"},{"id":"R10","pred":"Location","subj":"E5","obj":"T16"},{"id":"R11","pred":"Microorganism","subj":"E6","obj":"T17"},{"id":"R12","pred":"Location","subj":"E6","obj":"T15"},{"id":"R13","pred":"Microorganism","subj":"E7","obj":"T17"},{"id":"R14","pred":"Location","subj":"E7","obj":"T14"},{"id":"R15","pred":"Microorganism","subj":"E8","obj":"T34"},{"id":"R16","pred":"Location","subj":"E8","obj":"T33"},{"id":"R17","pred":"Microorganism","subj":"E9","obj":"T34"},{"id":"R18","pred":"Location","subj":"E9","obj":"T32"}],"text":"New one-week, low-dose triple therapy for the treatment of duodenal ulcer with Helicobacter pylori infection.\nAntimicrobial therapy is the recommended treatment for duodenal ulcer associated with Helicobacter pylori infection. The eradication of bismuth-based triple therapy with bismuth subcitrate, metronidazole and amoxicillin is limited by low compliance, drug resistance and side-effects. Two-week proton pump inhibitor (PPI)-based triple therapy has a higher eradication rate but is costly. This study was designed to compare the efficacy, patient compliance and cost of short-term PPI-based triple therapy with those of bismuth-based triple therapy.\nNinety patients with active duodenal ulcer disease and H pylori infection, proven with the 13C-urea breath test and CLO test (Campylobacter-like organism test) were treated randomly in three therapeutic groups: Group A, DeNol 120 mg, amoxicillin 500 mg and metronidazole 250 mg four times a day orally for 14 days; Group B, omeprazole 20 mg plus clarithromycin 500 mg twice a day and amoxicillin 500 mg four times a day for 14 days; Group C, omeprazole 20 mg, clarithromycin 250 mg and metronidazole 500 mg twice a day for seven days. Nizatidine 150 mg twice a day was given continuously following the end of anti-H pylori therapy for each group. Two months later, endoscopy, the CLO test and 13C-urea breath test were repeated to assess the eradication rate of H pylori and the ulcer-healing rate. Drug tolerance was evaluated by patients themselves by daily recording of any side-effects.\nEighty-four patients completed the entire course of therapy and evaluation for H pylori infection. The H pylori eradication rates in Groups A, B and C were 75% (21/28), 93% (26/28) and 89% (25/28), respectively (p = 0.466). The ulcer healing rate was 86% (24/28) in Group A and 89% (25/28) in Groups B and C (p = 0.764). A total of 74 patients (88%) were free from symptoms at the end of the triple therapy. Symptom relief was faster in patients with PPI-based triple therapy (Groups B and C) (days 3 and 4) than for patients with bismuth-based triple therapy (day 5). The cost of Group C therapy was lower than that for Groups A and B. There were no major side-effects in any of the patients.\nOne-week triple therapy with omeprazole, clarithromycin and metronidazole is highly effected for the eradication of H pylori. A therapeutic regime of one week's duration with lower cost, good compliance and mild side-effects may offer a good choice for treatment of duodenal ulcer associated with H pylori infection in clinical practice.\n\n"}