BB-rel@ldeleger:BB-rel-23908036 JSONTXT

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bionlp-ost-19-BB-rel-train

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Id Subject Object Predicate Lexical cue
T1 0-102 Title denotes Preliminary X-ray crystallographic analysis of β-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
T3 79-101 Microorganism denotes Pseudomonas aeruginosa
T2 103-1458 Paragraph denotes Pseudomonas aeruginosa is a Gram-negative bacterium that causes life-threatening infections in susceptible individuals and is resistant to most clinically available antimicrobials. Genomic and proteomic studies have identified three genes, pa0102, pa2053 and pa4676, in P. aeruginosa PAO1 encoding three functional β-carbonic anhydrases (β-CAs): psCA1, psCA2 and psCA3, respectively. These β-CAs could serve as novel antimicrobial drug targets for this pathogen. X-ray crystallographic structural studies have been initiated to characterize the structure and function of these proteins. This communication describes the production of two crystal forms (A and B) of β-CA psCA3. Form A diffracted to a resolution of 2.9 Å; it belonged to space group P212121, with unit-cell parameters a = 81.9, b = 84.9, c = 124.2 Å, and had a calculated Matthews coefficient of 2.23 ų Da⁻¹ assuming four molecules in the crystallographic asymmetric unit. Form B diffracted to a resolution of 3.0 Å; it belonged to space group P21212, with unit-cell parameters a = 69.9, b = 77.7, c = 88.5 Å, and had a calculated Matthews coefficient of 2.48 ų Da⁻¹ assuming two molecules in the crystallographic asymmetric unit. Preliminary molecular-replacement solutions have been determined with the PHENIX AutoMR wizard and refinement of both crystal forms is currently in progress.
T4 103-125 Microorganism denotes Pseudomonas aeruginosa
T5 131-144 Phenotype denotes Gram-negative
T6 198-221 Habitat denotes susceptible individuals
T7 229-282 Phenotype denotes resistant to most clinically available antimicrobials
T8 373-391 Microorganism denotes P. aeruginosa PAO1
T9 556-564 Phenotype denotes pathogen
E3 103-125 Lives_In denotes Pseudomonas aeruginosa
E1 103-125 Exhibits denotes Pseudomonas aeruginosa
E2 103-125 Exhibits denotes Pseudomonas aeruginosa
E4 373-391 Exhibits denotes P. aeruginosa PAO1
R1 E3 T4 Microorganism Pseudomonas aeruginosa,Pseudomonas aeruginosa
R2 E3 T6 Location Pseudomonas aeruginosa,susceptible individuals
R3 E1 T4 Microorganism Pseudomonas aeruginosa,Pseudomonas aeruginosa
R4 E1 T5 Property Pseudomonas aeruginosa,Gram-negative
R5 E2 T4 Microorganism Pseudomonas aeruginosa,Pseudomonas aeruginosa
R6 E2 T7 Property Pseudomonas aeruginosa,resistant to most clinically available antimicrobials
R7 E4 T8 Microorganism P. aeruginosa PAO1,P. aeruginosa PAO1
R8 E4 T9 Property P. aeruginosa PAO1,pathogen