BB-rel@ldeleger:BB-rel-21543877 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-135	Title	denotes	Cloning, expression, purification, crystallization and X-ray crystallographic analysis of Rv3168 from Mycobacterium tuberculosis H37Rv.
T3	102-134	Microorganism	denotes	Mycobacterium tuberculosis H37Rv
T2	136-1163	Paragraph	denotes	Tuberculosis is a widespread and deadly infectious disease, with one third of the human population already being infected. Aminoglycoside antibiotics have become less effective in recent years owing to antibiotic resistance, which arises primarily through enzymatic modification of the antibiotics. The gene product Rv3168, a putative aminoglycoside phosphotransferase (APH), from Mycobacterium tuberculosis was crystallized using the sitting-drop vapour-diffusion method in the presence of 0.2 M calcium acetate, 0.1 M Tris-HCl pH 7.0 and 20% PEG 3000 at 295 K. X-ray diffraction data were collected to a maximum resolution of 1.67 Å on a synchrotron beamline. The crystal belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 56.74, b = 62.37, c = 103.61 Å. With one molecule per asymmetric unit, the crystal volume per unit protein weight (V(M)) is 2.91 Å(3) Da(-1). The structure was solved by the single-wavelength anomalous dispersion method and refinement of the selenomethionine structure is in progress.
T4	218-234	Habitat	denotes	human population
T5	338-359	Phenotype	denotes	antibiotic resistance
T6	517-543	Microorganism	denotes	Mycobacterium tuberculosis