BB-rel@ldeleger:BB-rel-20174624 JSONTXT

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bionlp-ost-19-BB-rel-dev

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Id Subject Object Predicate Lexical cue
T1 0-143 Title denotes Neutrophils are resistant to Yersinia YopJ/P-induced apoptosis and are protected from ROS-mediated cell death by the type III secretion system.
T5 0-11 Habitat denotes Neutrophils
T6 29-37 Microorganism denotes Yersinia
T7 99-103 Habitat denotes cell
T8 117-135 Phenotype denotes type III secretion
T2 144-664 Paragraph denotes The human innate immune system relies on the coordinated activity of macrophages and polymorphonuclear leukocytes (neutrophils or PMNs) for defense against bacterial pathogens. Yersinia spp. subvert the innate immune response to cause disease in humans. In particular, the Yersinia outer protein YopJ (Y. pestis and Y. pseudotuberculosis) and YopP (Y. enterocolitica) rapidly induce apoptosis in murine macrophages and dendritic cells. However, the effects of Yersinia Yop J/P on neutrophil fate are not clearly defined.
T10 148-174 Habitat denotes human innate immune system
T9 148-153 Habitat denotes human
T11 213-224 Habitat denotes macrophages
T12 229-257 Habitat denotes polymorphonuclear leukocytes
T13 259-270 Habitat denotes neutrophils
T14 274-278 Habitat denotes PMNs
T15 300-319 Phenotype denotes bacterial pathogens
T16 321-329 Microorganism denotes Yersinia
T17 390-396 Habitat denotes humans
T18 417-425 Microorganism denotes Yersinia
T19 446-455 Microorganism denotes Y. pestis
T20 460-481 Microorganism denotes Y. pseudotuberculosis
T21 493-510 Microorganism denotes Y. enterocolitica
T22 540-558 Habitat denotes murine macrophages
T24 540-546 Habitat denotes murine
T23-1 540-546,563-578 Habitat denotes murine dendritic cells
T25 604-612 Microorganism denotes Yersinia
T26 624-634 Habitat denotes neutrophil
T3 665-1672 Paragraph denotes In this study, we utilized wild-type and mutant strains of Yersinia to test the contribution of YopJ and YopP on induction of apoptosis in human monocyte-derived macrophages (HMDM) and neutrophils. Whereas YopJ and YopP similarly induced apoptosis in HMDMs, interaction of human neutrophils with virulence plasmid-containing Yersinia did not result in PMN caspase activation, release of LDH, or loss of membrane integrity greater than PMN controls. In contrast, interaction of human PMNs with the virulence plasmid-deficient Y. pestis strain KIM6 resulted in increased surface exposure of phosphatidylserine (PS) and cell death. PMN reactive oxygen species (ROS) production was inhibited in a virulence plasmid-dependent but YopJ/YopP-independent manner. Following phagocytic interaction with Y. pestis strain KIM6, inhibition of PMN ROS production with diphenyleneiodonium chloride resulted in a reduction of PMN cell death similar to that induced by the virulence plasmid-containing strain Y. pestis KIM5.
T27 692-701 Phenotype denotes wild-type
T28 706-712 Phenotype denotes mutant
T29 724-732 Microorganism denotes Yersinia
T30 804-838 Habitat denotes human monocyte-derived macrophages
T31 804-809 Habitat denotes human
T32 840-844 Habitat denotes HMDM
T33 850-861 Habitat denotes neutrophils
T34 916-921 Habitat denotes HMDMs
T35 938-955 Habitat denotes human neutrophils
T36 938-943 Habitat denotes human
T37 961-970 Phenotype denotes virulence
T38 990-998 Microorganism denotes Yersinia
T39 1017-1020 Habitat denotes PMN
T40 1100-1103 Habitat denotes PMN
T41 1142-1152 Habitat denotes human PMNs
T42 1142-1147 Habitat denotes human
T43 1162-1171 Phenotype denotes virulence
T44 1190-1211 Microorganism denotes Y. pestis strain KIM6
T45 1282-1286 Habitat denotes cell
T46 1294-1297 Habitat denotes PMN
T47 1358-1367 Phenotype denotes virulence
T48 1458-1479 Microorganism denotes Y. pestis strain KIM6
T49 1495-1498 Habitat denotes PMN
T50 1575-1583 Habitat denotes PMN cell
T51 1621-1630 Phenotype denotes virulence
T52 1657-1671 Microorganism denotes Y. pestis KIM5
T4 1673-2071 Paragraph denotes Our findings showed that Yersinia YopJ and/or YopP did not induce pronounced apoptosis in human neutrophils. Furthermore, robust PMN ROS production in response to virulence plasmid-deficient Yersinia was associated with increased PMN cell death, suggesting that Yersinia inhibition of PMN ROS production plays a role in evasion of the human innate immune response in part by limiting PMN apoptosis.
T53 1698-1706 Microorganism denotes Yersinia
T54 1763-1780 Habitat denotes human neutrophils
T55 1763-1768 Habitat denotes human
T56 1802-1805 Habitat denotes PMN
T57 1836-1845 Phenotype denotes virulence
T58 1864-1872 Microorganism denotes Yersinia
T59 1903-1911 Habitat denotes PMN cell
T60 1935-1943 Microorganism denotes Yersinia
T61 1958-1961 Habitat denotes PMN
T62 2008-2013 Habitat denotes human
T63 2057-2060 Habitat denotes PMN
E1 321-329 Lives_In denotes Yersinia
E2 321-329 Exhibits denotes Yersinia
E3 417-425 Exhibits denotes Yersinia
E4 446-455 Exhibits denotes Y. pestis
E5 460-481 Exhibits denotes Y. pseudotuberculosis
E6 493-510 Exhibits denotes Y. enterocolitica
E7 724-732 Lives_In denotes Yersinia
E8 724-732 Exhibits denotes Yersinia
E9 990-998 Lives_In denotes Yersinia
E10 990-998 Exhibits denotes Yersinia
E11 1657-1671 Exhibits denotes Y. pestis KIM5
E12 1935-1943 Lives_In denotes Yersinia
R1 E1 T16 Microorganism Yersinia,Yersinia
R2 E1 T17 Location Yersinia,humans
R3 E2 T16 Microorganism Yersinia,Yersinia
R4 E2 T15 Property Yersinia,bacterial pathogens
R5 E3 T18 Microorganism Yersinia,Yersinia
R6 E3 T15 Property Yersinia,bacterial pathogens
R7 E4 T19 Microorganism Y. pestis,Y. pestis
R8 E4 T15 Property Y. pestis,bacterial pathogens
R9 E5 T20 Microorganism Y. pseudotuberculosis,Y. pseudotuberculosis
R10 E5 T15 Property Y. pseudotuberculosis,bacterial pathogens
R11 E6 T21 Microorganism Y. enterocolitica,Y. enterocolitica
R12 E6 T15 Property Y. enterocolitica,bacterial pathogens
R13 E7 T29 Microorganism Yersinia,Yersinia
R14 E7 T31 Location Yersinia,human
R15 E8 T29 Microorganism Yersinia,Yersinia
R16 E8 T27 Property Yersinia,wild-type
R17 E9 T38 Microorganism Yersinia,Yersinia
R18 E9 T36 Location Yersinia,human
R19 E10 T38 Microorganism Yersinia,Yersinia
R20 E10 T37 Property Yersinia,virulence
R21 E11 T52 Microorganism Y. pestis KIM5,Y. pestis KIM5
R22 E11 T51 Property Y. pestis KIM5,virulence
R23 E12 T60 Microorganism Yersinia,Yersinia
R24 E12 T62 Location Yersinia,human