BB-rel@ldeleger:BB-rel-20073421 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/BB-rel@ldeleger/sourceid/BB-rel-20073421","sourcedb":"BB-rel@ldeleger","sourceid":"BB-rel-20073421","text":"The effect of interferon-gamma and lipopolysaccharide on the growth of Francisella tularensis LVS in murine macrophage-like cell line J774.\nFrancisella tularensis, a causative agent of human tularemia, displaying the ability to proliferate inside the human cells.\nTo evaluate the growth potential of F. tularensis LVS strain in macrophage-like cell line J774 modulated by recombinant interferon gamma and E. coli derived lipopolysaccharide.\nStimulation of J774 cells either by interferon-gamma or lipopolysaccharide alone, or especially in combination before infection F. tularensis, revealed protective effects. Higher concentrations of stimulating agents were needed to inhibit ongoing F. tularensis infection.\nStimulation of J774 cell line by combination of interferon-gamma with lipopolysaccharide inhibits the intracellular growth of F. 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