BB-rel@ldeleger:BB-rel-19049879 / 89-1466 JSONTXT

Annnotations TAB JSON ListView MergeView

bionlp-ost-19-BB-rel-train

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2 0-1377 Paragraph denotes Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor and Toll-like receptor-induced activation of nuclear factor-kappaB (NF-kappaB). In this report, the full-length cDNA of MyD88 was cloned from the large yellow croaker, Pseudosciaena crocea. It was of 1574 bp, including a 5'-terminal untranslated region (UTR) of 89 bp, a 3'-terminal UTR of 621bp and an open reading frame (ORF) of 864 bp encoding a polypeptide of 287 amino acids. It contained a typical death domain at the N-terminal and a conservative Toll/IL-1R (TIR) domain structure at the C-terminal. The quantitative real-time reverse transcription PCR analysis revealed a broad expression of MyD88 with the highest expression in the spleen and the weakest expression in the muscle. The expression of MyD88 after challenge with formalin-inactivated Gram-negative bacterium Vibrio parahaemolyticus was tested in blood, spleen and liver. It suggested that the highest expression was in the spleen (p<0.05) with 1.9 times (at 48 h) as much as that in the control and the lowest expression of MyD88 was in the liver (p<0.05) with 0.29 times (at 3h) of that in the control. These results indicated that as a universal key adaptor in the Toll-like receptor pathway in mammals, MyD88 might play an important role in large yellow croaker defense against pathogenic infection.
T5 249-269 Habitat denotes large yellow croaker
T6 271-291 Habitat denotes Pseudosciaena crocea
T7 744-750 Habitat denotes spleen
T8 785-791 Habitat denotes muscle
T9 859-872 Phenotype denotes Gram-negative
T10 883-906 Microorganism denotes Vibrio parahaemolyticus
T11 921-926 Habitat denotes blood
T12 928-934 Habitat denotes spleen
T13 939-944 Habitat denotes liver
T14 998-1004 Habitat denotes spleen
T15 1116-1121 Habitat denotes liver
T16 1272-1279 Habitat denotes mammals
T17 1319-1339 Habitat denotes large yellow croaker
T18 1356-1366 Phenotype denotes pathogenic
E1 883-906 Exhibits denotes Vibrio parahaemolyticus
R1 E1 T10 Microorganism Vibrio parahaemolyticus,Vibrio parahaemolyticus
R2 E1 T9 Property Vibrio parahaemolyticus,Gram-negative