BB-rel@ldeleger:BB-rel-16990433 JSONTXT

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bionlp-ost-19-BB-rel-train

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Id Subject Object Predicate Lexical cue
T1 0-136 Title denotes An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination.
T3 27-45 Phenotype denotes type III secretion
T4 59-80 Microorganism denotes Escherichia coli O157
T5 97-112 Microorganism denotes lambdoid phages
T2 137-1580 Paragraph denotes Several pathogenic strains of Escherichia coli exploit type III secretion to inject "effector proteins" into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. We have exploited bioinformatics and experimental approaches to establish that the effector repertoire in the Sakai strain of enterohemorrhagic E. coli (EHEC) O157:H7 is much larger than previously thought. Homology searches led to the identification of >60 putative effector genes. Thirteen of these were judged to be likely pseudogenes, whereas 49 were judged to be potentially functional. In total, 39 proteins were confirmed experimentally as effectors: 31 through proteomics and 28 through translocation assays. At the protein level, the EHEC effector sequences fall into >20 families. The largest family, the NleG family, contains 14 members in the Sakai strain alone. EHEC also harbors functional homologs of effectors from plant pathogens (HopPtoH, HopW, AvrA) and from Shigella (OspD, OspE, OspG), and two additional members of the Map/IpgB family. Genes encoding proven or predicted effectors occur in >20 exchangeable effector loci scattered throughout the chromosome. Crucially, the majority of functional effector genes are encoded by nine exchangeable effector loci that lie within lambdoid prophages. Thus, type III secretion in E. coli is linked to a vast phage "metagenome," acting as a crucible for the evolution of pathogenicity.
T6 145-155 Phenotype denotes pathogenic
T7 167-183 Microorganism denotes Escherichia coli
T8 192-210 Phenotype denotes type III secretion
T9 246-257 Habitat denotes human cells
T10 246-251 Habitat denotes human
T11 278-293 Habitat denotes eukaryotic cell
T12 442-447 Microorganism denotes Sakai
T13 458-475 Phenotype denotes enterohemorrhagic
T14 476-498 Microorganism denotes E. coli (EHEC) O157:H7
T15 485-489 Phenotype denotes EHEC
T16 875-879 Phenotype denotes EHEC
T17 875-879 Microorganism denotes EHEC
T18 987-992 Microorganism denotes Sakai
T19 1007-1011 Phenotype denotes EHEC
T20 1007-1011 Microorganism denotes EHEC
T21 1063-1078 Phenotype denotes plant pathogens
T22 1063-1068 Habitat denotes plant
T23 1110-1118 Microorganism denotes Shigella
T24 1428-1446 Microorganism denotes lambdoid prophages
T25 1454-1472 Phenotype denotes type III secretion
T26 1476-1483 Microorganism denotes E. coli
T27 1566-1579 Phenotype denotes pathogenicity
E1 59-80 Exhibits denotes Escherichia coli O157
E4 167-183 Lives_In denotes Escherichia coli
E2 167-183 Exhibits denotes Escherichia coli
E3 167-183 Exhibits denotes Escherichia coli
E5 476-498 Exhibits denotes E. coli (EHEC) O157:H7
E6 476-498 Exhibits denotes E. coli (EHEC) O157:H7
E7 875-879 Exhibits denotes EHEC
E8 1007-1011 Exhibits denotes EHEC
E9 1476-1483 Exhibits denotes E. coli
R1 E1 T4 Microorganism Escherichia coli O157,Escherichia coli O157
R2 E1 T3 Property Escherichia coli O157,type III secretion
R3 E4 T7 Microorganism Escherichia coli,Escherichia coli
R4 E4 T10 Location Escherichia coli,human
R5 E2 T7 Microorganism Escherichia coli,Escherichia coli
R6 E2 T6 Property Escherichia coli,pathogenic
R7 E3 T7 Microorganism Escherichia coli,Escherichia coli
R8 E3 T8 Property Escherichia coli,type III secretion
R9 E5 T14 Microorganism E. coli (EHEC) O157:H7,E. coli (EHEC) O157:H7
R10 E5 T13 Property E. coli (EHEC) O157:H7,enterohemorrhagic
R11 E6 T14 Microorganism E. coli (EHEC) O157:H7,E. coli (EHEC) O157:H7
R12 E6 T15 Property E. coli (EHEC) O157:H7,EHEC
R13 E7 T17 Microorganism EHEC,EHEC
R14 E7 T16 Property EHEC,EHEC
R15 E8 T20 Microorganism EHEC,EHEC
R16 E8 T19 Property EHEC,EHEC
R17 E9 T26 Microorganism E. coli,E. coli
R18 E9 T25 Property E. coli,type III secretion