BB-norm@ldeleger:BB-norm-9745160 JSONTXT

{"project":"bionlp-ost-19-BB-norm-dev","denotations":[{"id":"T13","span":{"begin":546,"end":553},"obj":"Habitat"},{"id":"T3","span":{"begin":657,"end":1547},"obj":"Paragraph"},{"id":"T14","span":{"begin":664,"end":730},"obj":"Habitat"},{"id":"T15","span":{"begin":685,"end":699},"obj":"Habitat"},{"id":"T16","span":{"begin":685,"end":693},"obj":"Habitat"},{"id":"T17","span":{"begin":712,"end":720},"obj":"Microorganism"},{"id":"T18","span":{"begin":783,"end":796},"obj":"Microorganism"},{"id":"T19","span":{"begin":1271,"end":1279},"obj":"Microorganism"},{"id":"T20","span":{"begin":1419,"end":1427},"obj":"Microorganism"},{"id":"T21","span":{"begin":1436,"end":1441},"obj":"Habitat"},{"id":"T22","span":{"begin":1488,"end":1496},"obj":"Habitat"},{"id":"T4","span":{"begin":1548,"end":2241},"obj":"Paragraph"},{"id":"T23","span":{"begin":1560,"end":1568},"obj":"Habitat"},{"id":"T24","span":{"begin":1627,"end":1635},"obj":"Microorganism"},{"id":"T25","span":{"begin":1651,"end":1659},"obj":"Microorganism"},{"id":"T26","span":{"begin":1776,"end":1781},"obj":"Habitat"},{"id":"T27","span":{"begin":1883,"end":1891},"obj":"Habitat"},{"id":"T28","span":{"begin":1985,"end":2023},"obj":"Habitat"},{"id":"T29","span":{"begin":2065,"end":2107},"obj":"Habitat"},{"id":"T30","span":{"begin":2232,"end":2240},"obj":"Habitat"},{"id":"T5","span":{"begin":2242,"end":2579},"obj":"Paragraph"},{"id":"T31","span":{"begin":2358,"end":2366},"obj":"Microorganism"},{"id":"T33","span":{"begin":2508,"end":2522},"obj":"Habitat"},{"id":"T32","span":{"begin":2508,"end":2516},"obj":"Habitat"},{"id":"T34","span":{"begin":2539,"end":2547},"obj":"Microorganism"},{"id":"T1","span":{"begin":0,"end":109},"obj":"Title"},{"id":"T7","span":{"begin":59,"end":73},"obj":"Habitat"},{"id":"T6","span":{"begin":59,"end":67},"obj":"Habitat"},{"id":"T8","span":{"begin":79,"end":98},"obj":"Microorganism"},{"id":"T2","span":{"begin":110,"end":656},"obj":"Paragraph"},{"id":"T9","span":{"begin":165,"end":179},"obj":"Habitat"},{"id":"T10","span":{"begin":165,"end":173},"obj":"Habitat"},{"id":"T11","span":{"begin":196,"end":215},"obj":"Microorganism"},{"id":"T12","span":{"begin":360,"end":375},"obj":"Phenotype"}],"attributes":[{"id":"A26","pred":"NCBI_Taxonomy","subj":"T31","obj":"210"},{"id":"A20","pred":"NCBI_Taxonomy","subj":"T25","obj":"210"},{"id":"A2","pred":"OntoBiotope","subj":"T7","obj":"OBT:001533"},{"id":"A10","pred":"OntoBiotope","subj":"T15","obj":"OBT:001533"},{"id":"A11","pred":"OntoBiotope","subj":"T16","obj":"OBT:001534"},{"id":"A4","pred":"OntoBiotope","subj":"T9","obj":"OBT:001533"},{"id":"A25","pred":"OntoBiotope","subj":"T30","obj":"OBT:003269"},{"id":"A14","pred":"NCBI_Taxonomy","subj":"T19","obj":"210"},{"id":"A24","pred":"OntoBiotope","subj":"T29","obj":"OBT:003269"},{"id":"A8","pred":"OntoBiotope","subj":"T13","obj":"OBT:003220"},{"id":"A22","pred":"OntoBiotope","subj":"T27","obj":"OBT:003269"},{"id":"A17","pred":"OntoBiotope","subj":"T22","obj":"OBT:003269"},{"id":"A5","pred":"OntoBiotope","subj":"T10","obj":"OBT:001534"},{"id":"A9","pred":"OntoBiotope","subj":"T14","obj":"OBT:003269"},{"id":"A23","pred":"OntoBiotope","subj":"T28","obj":"OBT:003269"},{"id":"A7","pred":"OntoBiotope","subj":"T12","obj":"OBT:000598"},{"id":"A18","pred":"OntoBiotope","subj":"T23","obj":"OBT:003269"},{"id":"A28","pred":"OntoBiotope","subj":"T33","obj":"OBT:001533"},{"id":"A29","pred":"NCBI_Taxonomy","subj":"T34","obj":"210"},{"id":"A3","pred":"NCBI_Taxonomy","subj":"T8","obj":"210"},{"id":"A15","pred":"NCBI_Taxonomy","subj":"T20","obj":"210"},{"id":"A6","pred":"NCBI_Taxonomy","subj":"T11","obj":"210"},{"id":"A21","pred":"OntoBiotope","subj":"T26","obj":"OBT:000933"},{"id":"A12","pred":"NCBI_Taxonomy","subj":"T17","obj":"210"},{"id":"A1","pred":"OntoBiotope","subj":"T6","obj":"OBT:001534"},{"id":"A13","pred":"NCBI_Taxonomy","subj":"T18","obj":"194"},{"id":"A19","pred":"NCBI_Taxonomy","subj":"T24","obj":"210"},{"id":"A27","pred":"OntoBiotope","subj":"T32","obj":"OBT:001534"},{"id":"A16","pred":"OntoBiotope","subj":"T21","obj":"OBT:001533"}],"text":"New one-week, low-dose triple therapy for the treatment of duodenal ulcer with Helicobacter pylori infection.\nAntimicrobial therapy is the recommended treatment for duodenal ulcer associated with Helicobacter pylori infection. The eradication of bismuth-based triple therapy with bismuth subcitrate, metronidazole and amoxicillin is limited by low compliance, drug resistance and side-effects. Two-week proton pump inhibitor (PPI)-based triple therapy has a higher eradication rate but is costly. This study was designed to compare the efficacy, patient compliance and cost of short-term PPI-based triple therapy with those of bismuth-based triple therapy.\nNinety patients with active duodenal ulcer disease and H pylori infection, proven with the 13C-urea breath test and CLO test (Campylobacter-like organism test) were treated randomly in three therapeutic groups: Group A, DeNol 120 mg, amoxicillin 500 mg and metronidazole 250 mg four times a day orally for 14 days; Group B, omeprazole 20 mg plus clarithromycin 500 mg twice a day and amoxicillin 500 mg four times a day for 14 days; Group C, omeprazole 20 mg, clarithromycin 250 mg and metronidazole 500 mg twice a day for seven days. Nizatidine 150 mg twice a day was given continuously following the end of anti-H pylori therapy for each group. Two months later, endoscopy, the CLO test and 13C-urea breath test were repeated to assess the eradication rate of H pylori and the ulcer-healing rate. Drug tolerance was evaluated by patients themselves by daily recording of any side-effects.\nEighty-four patients completed the entire course of therapy and evaluation for H pylori infection. The H pylori eradication rates in Groups A, B and C were 75% (21/28), 93% (26/28) and 89% (25/28), respectively (p = 0.466). The ulcer healing rate was 86% (24/28) in Group A and 89% (25/28) in Groups B and C (p = 0.764). A total of 74 patients (88%) were free from symptoms at the end of the triple therapy. Symptom relief was faster in patients with PPI-based triple therapy (Groups B and C) (days 3 and 4) than for patients with bismuth-based triple therapy (day 5). The cost of Group C therapy was lower than that for Groups A and B. There were no major side-effects in any of the patients.\nOne-week triple therapy with omeprazole, clarithromycin and metronidazole is highly effected for the eradication of H pylori. A therapeutic regime of one week's duration with lower cost, good compliance and mild side-effects may offer a good choice for treatment of duodenal ulcer associated with H pylori infection in clinical practice.\n\n"}