BB-norm@ldeleger:BB-norm-23895665 JSONTXT

{"project":"bionlp-ost-19-BB-norm-test","denotations":[{"id":"T1","span":{"begin":0,"end":163},"obj":"Title"},{"id":"T6","span":{"begin":14,"end":24},"obj":"Habitat"},{"id":"T7","span":{"begin":119,"end":133},"obj":"Phenotype"},{"id":"T2","span":{"begin":164,"end":537},"obj":"Paragraph"},{"id":"T8","span":{"begin":264,"end":278},"obj":"Phenotype"},{"id":"T9","span":{"begin":358,"end":361},"obj":"Microorganism"},{"id":"T10","span":{"begin":436,"end":448},"obj":"Habitat"},{"id":"T11","span":{"begin":473,"end":488},"obj":"Phenotype"},{"id":"T3","span":{"begin":538,"end":873},"obj":"Paragraph"},{"id":"T12","span":{"begin":572,"end":582},"obj":"Habitat"},{"id":"T13","span":{"begin":678,"end":693},"obj":"Phenotype"},{"id":"T14","span":{"begin":784,"end":790},"obj":"Habitat"},{"id":"T15","span":{"begin":803,"end":831},"obj":"Habitat"},{"id":"T16","span":{"begin":848,"end":864},"obj":"Phenotype"},{"id":"T4","span":{"begin":874,"end":1171},"obj":"Paragraph"},{"id":"T17","span":{"begin":881,"end":891},"obj":"Habitat"},{"id":"T18","span":{"begin":911,"end":914},"obj":"Microorganism"},{"id":"T19","span":{"begin":1048,"end":1062},"obj":"Habitat"},{"id":"T20","span":{"begin":1078,"end":1088},"obj":"Habitat"},{"id":"T5","span":{"begin":1172,"end":1440},"obj":"Paragraph"},{"id":"T21","span":{"begin":1212,"end":1215},"obj":"Microorganism"},{"id":"T22","span":{"begin":1260,"end":1281},"obj":"Habitat"},{"id":"T23","span":{"begin":1299,"end":1315},"obj":"Phenotype"},{"id":"T24","span":{"begin":1344,"end":1356},"obj":"Habitat"}],"text":"Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug-resistant tuberculosis in South Africa.\nThe World Health Organization has endorsed the use of molecular methods for the detection of TB and drug-resistant TB as a rapid alternative to culture-based systems. In South Africa, the Xpert MTB/Rif assay and the GenoType MTBDRplus have been implemented into reference laboratories for diagnosis of TB and drug-resistance, but their costs have not been fully elucidated.\nWe conducted a detailed reference laboratory cost analysis of new rapid molecular assays (Xpert and MTBDRplus) for tuberculosis testing and drug-resistance testing in South Africa, and compared with the costs of conventional approaches involving sputum microscopy, liquid mycobacterial culture, and phenotypic drug sensitivity testing.\nFrom a laboratory perspective, Xpert MTB/RIF cost $14.93/sample and the MTBDRplus line probe assay cost $23.46/sample, compared to $16.88/sample using conventional automated liquid culture-based methods. Laboratory costs of Xpert and MTBDRplus were most influenced by cost of consumables (60-80%).\nAt current public sector pricing, Xpert MTB/RIF and MTBDRplus are comparable in cost to mycobacterial culture and conventional drug sensitivity testing. Overall, reference laboratories must balance costs with performance characteristics and the need for rapid results.\n\n"}