BB-norm+ner@ldeleger:BB-norm+ner-24361838 / 115-2050 JSONTXT

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bionlp-ost-19-BB-norm-ner-train

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T2 0-1935 Paragraph denotes In this study, a Salmonella Typhimurium lytic bacteriophage, Φ st1, which was isolated from chicken faecal material, was evaluated as a candidate for biocontrol of Salmonella in chickens. The morphology of Φ st1 showed strong resemblance to members of the Siphoviridae family. Φ st1 was observed to be a DNA phage with an estimated genome size of 121 kbp. It was found to be able to infect S. Typhimurium and S. Hadar, with a stronger lytic activity against the former. Subsequent characterisation of Φ st1 against S. Typhimurium showed that Φ st1 has a latent period of 40 min with an average burst size of 22 particles per infective centre. Approximately 86.1% of the phage adsorbed to the host cells within the initial 5 min of infection. At the optimum multiplicity of infection (MOI) (0.1), the highest reduction rate of S. Typhimurium (6.6 log₁₀ CFU/ml) and increment in phage titre (3.8 log₁₀ PFU/ml) was observed. Φ st1 produced adsorption rates of 88.4-92.2% at pH7-9 and demonstrated the highest bacteria reduction (6.6 log₁₀ CFU/ml) at pH9. Φ st1 also showed an insignificant different (P>0.05) reduction rate of host cells at 37 °C (6.4 log₁₀ CFU/ml) and 42 °C (6.0 log₁₀ CFU/ml). The in vivo study using Φ st1 showed that intracloacal inoculation of ~10¹² PFU/ml of the phage in the chickens challenged with ~10¹⁰ CFU/ml of S. Typhimurium was able to reduce (P<0.05) the S. Typhimurium more rapidly than the untreated group. The Salmonella count reduced to 2.9 log₁₀ CFU/ml within 6h of post-challenge and S. Typhimurium was not detected at and after 24h of post-challenge. Reduction of Salmonella count in visceral organs was also observed at 6h post-challenge. Approximately 1.6 log₁₀ FU/ml Φ st1 was found to persist in the caecal wall of the chicks at 72 h of post-challenge. The present study indicated that Φ st1 may serve as a potential biocontrol agent to reduce the Salmonella count in caecal content of chickens.
T7 17-59 Microorganism denotes Salmonella Typhimurium lytic bacteriophage 12333
T8 17-39 Microorganism denotes Salmonella Typhimurium 90371
T9 40-45 Phenotype denotes lytic OBT:000107
T10 61-66 Microorganism denotes Φ st1 12333
T12 92-115 Habitat denotes chicken faecal material OBT:001102
T11 92-99 Habitat denotes chicken OBT:003314
T13 164-174 Microorganism denotes Salmonella 590
T14 178-186 Habitat denotes chickens OBT:003314
T15 206-211 Microorganism denotes Φ st1 12333
T16 256-268 Microorganism denotes Siphoviridae 10699
T17 277-282 Microorganism denotes Φ st1 12333
T18 390-404 Microorganism denotes S. Typhimurium 90371
T19 409-417 Microorganism denotes S. Hadar 149385
T20 435-449 Phenotype denotes lytic activity OBT:000107
T21 501-506 Microorganism denotes Φ st1 12333
T22 515-529 Microorganism denotes S. Typhimurium 90371
T23 542-547 Microorganism denotes Φ st1 12333
T24 692-702 Habitat denotes host cells OBT:000061
T25 826-840 Microorganism denotes S. Typhimurium 90371
T26 922-927 Microorganism denotes Φ st1 12333
T27 1052-1057 Microorganism denotes Φ st1 12333
T28 1124-1134 Habitat denotes host cells OBT:000061
T29 1217-1222 Microorganism denotes Φ st1 12333
T30 1235-1247 Habitat denotes intracloacal OBT:001488
T31 1296-1304 Habitat denotes chickens OBT:003314|OBT:000700
T32 1337-1351 Microorganism denotes S. Typhimurium 90371
T33 1384-1398 Microorganism denotes S. Typhimurium 90371
T34 1442-1452 Microorganism denotes Salmonella 590
T35 1519-1533 Microorganism denotes S. Typhimurium 90371
T36 1600-1610 Microorganism denotes Salmonella 590
T37 1620-1635 Habitat denotes visceral organs OBT:000364
T38 1706-1711 Microorganism denotes Φ st1 12333
T40 1740-1765 Habitat denotes caecal wall of the chicks OBT:001006
T39 1740-1746 Habitat denotes caecal OBT:001471
T41 1759-1765 Habitat denotes chicks OBT:000700|OBT:003314|OBT:003263
T42 1826-1831 Microorganism denotes Φ st1 12333
T43 1888-1898 Microorganism denotes Salmonella 590
T44 1908-1934 Habitat denotes caecal content of chickens OBT:001470
T45 1908-1914 Habitat denotes caecal OBT:001471
T46 1926-1934 Habitat denotes chickens OBT:003314