BB-norm+ner@ldeleger:BB-norm+ner-23902156 / 91-1393 JSONTXT

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bionlp-ost-19-BB-norm-ner-dev

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T2 0-1302 Paragraph denotes A ribosomal P1 protein, Pen b 26 from Penicillium brevicompactum, was previously identified as a major allergen. A homolog protein was isolated and characterized from Penicillium crustosum which is not known to be allergenic mold. A cDNA library of P. crustosum was constructed and screened using a probe based on the DNA sequence of Pen b 26. A positive clone was isolated, expressed in Escherichia coli, purified and characterized by comparing its immunological and physical properties to Pen b 26. It was designated as Pen cr 26 and had a 321 nt ORF corresponding to 107 amino acids with a MW of 11 kDa. Pen cr 26 had strong sequence homology to Pen b 26 (92% for nucleotides and 86% for amino acids) and its physical and predicted structural properties were similar to the latter. The level of expression of Pen cr 26 was much lower than that of Pen b 26 in the same expression vector. Both proteins were recognized equally well by the IgG class specific antibodies, but Pen cr 26 was poorly recognized by Penicillium-sensitive atopic sera (IgE), suggesting striking antigenic difference in IgE epitopes, i.e., 87% were positive for Pen b 26 while only 23% were positive for Pen cr 26. The allergenicity of Pen cr 26 seems to be minor in nature and it could be a hypoallergenic variant of Pen b 26.
T4 38-64 Microorganism denotes Penicillium brevicompactum 5074
T5 167-188 Microorganism denotes Penicillium crustosum 36656
T6 249-261 Microorganism denotes P. crustosum 36656
T7 388-404 Microorganism denotes Escherichia coli 562
T9 1010-1043 Habitat denotes Penicillium-sensitive atopic sera OBT:000007
T8 1010-1021 Microorganism denotes Penicillium 5073