BB-norm+ner@ldeleger:BB-norm+ner-21695078 JSONTXT

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bionlp-ost-19-BB-norm-ner-dev

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-99 Title denotes Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.
T2 100-1061 Paragraph denotes Chlamydia trachomatis is a common sexually transmitted pathogen and is associated with infant pneumonia. Data from the female mouse model of genital tract chlamydia infection suggests a requirement for TLR2-dependent signaling in the induction of inflammation and oviduct pathology. We hypothesized that the role of TLR2 in moderating mucosal inflammation is site specific. In order to investigate this, we infected mice via the intranasal route with C. muridarum and observed that in the absence of TLR2 activation, mice had more severe disease, higher lung cytokine levels, and an exaggerated influx of neutrophils and T-cells into the lungs. This could not be explained by impaired bacterial clearance as TLR2-deficient mice cleared the infection similar to controls. These data suggest that TLR2 has an anti-inflammatory function in the lung during Chlamydia infection, and that the role of TLR2 in mucosal inflammation varies at different mucosal surfaces.
T3 9-18 Phenotype denotes virulence OBT:000375
T4 22-41 Microorganism denotes Chlamydia muridarum 83560
T5 42-53 Habitat denotes respiratory OBT:000407
T6 100-121 Microorganism denotes Chlamydia trachomatis 813
T7 134-163 Phenotype denotes sexually transmitted pathogen OBT:002669
T8 187-193 Habitat denotes infant OBT:003263
T9 219-274 Habitat denotes female mouse model of genital tract chlamydia infection OBT:001103|OBT:003211
T10 241-254 Habitat denotes genital tract OBT:000643
T11 255-264 Microorganism denotes chlamydia 810
T12 364-371 Habitat denotes oviduct OBT:000463
T13 435-442 Habitat denotes mucosal OBT:001218
T14 516-520 Habitat denotes mice OBT:003211|OBT:001103
T15 529-539 Habitat denotes intranasal OBT:000767
T16 551-563 Microorganism denotes C. muridarum 83560
T17 617-621 Habitat denotes mice OBT:001103|OBT:003211
T18 654-658 Habitat denotes lung OBT:000716
T19 705-716 Habitat denotes neutrophils OBT:003004
T20 721-728 Habitat denotes T-cells OBT:001623
T21 738-743 Habitat denotes lungs OBT:000716
T22 808-827 Habitat denotes TLR2-deficient mice OBT:003211|OBT:001103
T23 941-945 Habitat denotes lung OBT:000716
T24 953-962 Microorganism denotes Chlamydia 810
T25 1003-1010 Habitat denotes mucosal OBT:001218
T26 1044-1060 Habitat denotes mucosal surfaces OBT:001654