BB-norm+ner@ldeleger:BB-norm+ner-19501788 / 124-1683 JSONTXT

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bionlp-ost-19-BB-norm-ner-train

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T2 0-1559 Paragraph denotes Ferric uptake regulator (Fur) is a global transcription regulator that is ubiquitous to Gram-negative bacteria and regulates diverse biological processes, including iron uptake, cellular metabolism, stress response, and production of virulence determinants. As a result, for many pathogenic bacteria, Fur plays a crucial role in the course of infection and disease development. In this study, the fur gene was cloned from a pathogenic Pseudomonas fluorescens strain, TSS, isolated from diseased Japanese flounder cultured in a local farm. TSS Fur can partially complement the defective phenotype of an Escherichia coli fur mutant. A TSS fur null mutant, TFM, was constructed. Compared to TSS, TFM exhibits reduced growth ability, aberrant production of outer membrane proteins, decreased resistance against host serum bactericidal activity, impaired ability to disseminate in host blood and tissues, and drastic attenuation in overall bacterial virulence in a Japanese flounder infection model. When used as a live vaccine administered via the injection, immersion, and oral routes, TFM affords high levels of protection upon Japanese flounder against not only P. fluorescens infection but also Aeromonas hydrophila infection. Furthermore, a plasmid, pJAQ, was constructed, which expresses the coding element of the Vibrio harveyi antigen AgaV-DegQ. TFM harboring pJAQ can secret AgaV-DegQ into the extracellular milieu. Vaccination of Japanese flounder with live TFM/pJAQ elicited strong immunoprotection against both V. harveyi and A. hydrophila infections.
T5 88-101 Phenotype denotes Gram-negative OBT:000648
T6 234-243 Phenotype denotes virulence OBT:000375
T7 280-290 Phenotype denotes pathogenic OBT:000375
T8 424-434 Phenotype denotes pathogenic OBT:002669
T9 435-470 Microorganism denotes Pseudomonas fluorescens strain, TSS 294
T10 486-537 Habitat denotes diseased Japanese flounder cultured in a local farm OBT:000491|OBT:003553
T11 527-537 Habitat denotes local farm OBT:000630
T12 539-542 Microorganism denotes TSS 294
T13 602-618 Microorganism denotes Escherichia coli 562
T14 619-629 Phenotype denotes fur mutant OBT:000118
T15 633-636 Microorganism denotes TSS 294
T16 637-652 Phenotype denotes fur null mutant OBT:000118
T17 654-657 Microorganism denotes TFM 562
T18 688-691 Microorganism denotes TSS 294
T19 693-696 Microorganism denotes TFM 562
T20 778-839 Phenotype denotes decreased resistance against host serum bactericidal activity OBT:000152
T21 807-817 Habitat denotes host serum OBT:000524
T23 876-886 Habitat denotes host blood OBT:000521
T22-0 876-880 _FRAGMENT denotes host OBT:000196
T22-1 891-898 Habitat denotes tissues
T24 935-954 Phenotype denotes bacterial virulence OBT:002669
T25 960-977 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T26 1010-1022 Habitat denotes live vaccine OBT:000464
T27 1070-1074 Habitat denotes oral OBT:001653
T28 1083-1086 Microorganism denotes TFM 562
T29 1126-1143 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T30 1161-1175 Microorganism denotes P. fluorescens 294
T31 1195-1215 Microorganism denotes Aeromonas hydrophila 644
T32 1316-1330 Microorganism denotes Vibrio harveyi 669
T33 1350-1353 Microorganism denotes TFM 562
T34 1436-1453 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T35 1464-1467 Microorganism denotes TFM 562
T36 1519-1529 Microorganism denotes V. harveyi 669
T37 1534-1547 Microorganism denotes A. hydrophila 644
C-T22-0 T22-1 T22-0 _lexicallyChainedTo tissues,host