BB-norm+ner@ldeleger:BB-norm+ner-19049879 JSONTXT

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bionlp-ost-19-BB-norm-ner-train

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-88 Title denotes Molecular cloning and expression of MyD88 in large yellow croaker, Pseudosciaena crocea.
T2 89-1466 Paragraph denotes Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor and Toll-like receptor-induced activation of nuclear factor-kappaB (NF-kappaB). In this report, the full-length cDNA of MyD88 was cloned from the large yellow croaker, Pseudosciaena crocea. It was of 1574 bp, including a 5'-terminal untranslated region (UTR) of 89 bp, a 3'-terminal UTR of 621bp and an open reading frame (ORF) of 864 bp encoding a polypeptide of 287 amino acids. It contained a typical death domain at the N-terminal and a conservative Toll/IL-1R (TIR) domain structure at the C-terminal. The quantitative real-time reverse transcription PCR analysis revealed a broad expression of MyD88 with the highest expression in the spleen and the weakest expression in the muscle. The expression of MyD88 after challenge with formalin-inactivated Gram-negative bacterium Vibrio parahaemolyticus was tested in blood, spleen and liver. It suggested that the highest expression was in the spleen (p<0.05) with 1.9 times (at 48 h) as much as that in the control and the lowest expression of MyD88 was in the liver (p<0.05) with 0.29 times (at 3h) of that in the control. These results indicated that as a universal key adaptor in the Toll-like receptor pathway in mammals, MyD88 might play an important role in large yellow croaker defense against pathogenic infection.
T3 45-65 Habitat denotes large yellow croaker OBT:003264
T4 67-87 Habitat denotes Pseudosciaena crocea OBT:003264
T5 338-358 Habitat denotes large yellow croaker OBT:003264
T6 360-380 Habitat denotes Pseudosciaena crocea OBT:003264
T7 833-839 Habitat denotes spleen OBT:000890
T8 874-880 Habitat denotes muscle OBT:001226
T9 948-961 Phenotype denotes Gram-negative OBT:000648
T10 972-995 Microorganism denotes Vibrio parahaemolyticus 670
T11 1010-1015 Habitat denotes blood OBT:000521
T12 1017-1023 Habitat denotes spleen OBT:000890
T13 1028-1033 Habitat denotes liver OBT:002725
T14 1087-1093 Habitat denotes spleen OBT:000890
T15 1205-1210 Habitat denotes liver OBT:002725
T16 1361-1368 Habitat denotes mammals OBT:001625
T17 1408-1428 Habitat denotes large yellow croaker OBT:003264
T18 1445-1455 Phenotype denotes pathogenic OBT:002669