BB-norm+ner@ldeleger:BB-norm+ner-16436701 / 92-1342 JSONTXT

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bionlp-ost-19-BB-norm-ner-train

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T2 0-1250 Paragraph denotes Antibacterial properties of the frog-derived peptide dermaseptin S4 and a series of synthetic derivatives against the food pathogen Escherichia coli O157:H7 were investigated under extreme incubation conditions. The 28-mer analog K4K20S4 (P28) displayed an MIC of 8 microM and rapid bactericidal kinetics under standard culture conditions. Potent bactericidal properties were maintained at high salt concentrations, under acidic or basic conditions, and at extreme temperatures. The N-terminal 14-mer sequence (P14) displayed higher potency (MIC, 4 microM) but only within a narrow range of incubation conditions, pointing to the importance of the C-terminal domain of P28. The potency range was reextended upon conjugation of aminododecanoic acid to P14. The resulting lipopeptide was even more potent (MIC, 2 microM) and affected bacterial viability under most of the conditions tested, including in commercial apple juice. The mechanistic implications of peptides' hydrophobicity, charge, structure, and binding to an idealized membrane were probed and are discussed here. Collectively, the data indicate interest in simple peptide-based compounds for design of antimicrobials that affect pathogens under a variable range of incubation conditions.
T3 32-36 Habitat denotes frog OBT:003052
T4 118-122 Habitat denotes food OBT:000094
T5 123-131 Phenotype denotes pathogen OBT:000375
T6 132-156 Microorganism denotes Escherichia coli O157:H7 83334
T7 902-924 Habitat denotes commercial apple juice OBT:003575
T8 1192-1201 Phenotype denotes pathogens OBT:000375